ZA200506790B - Arylvinylazacycloalkane compounds and method of preparation and use thereof - Google Patents

Arylvinylazacycloalkane compounds and method of preparation and use thereof

Info

Publication number: ZA200506790B
Authority: ZA; South Africa
Prior art keywords: preparation; arylvinylazacycloalkane; compounds; arylvinylazacycloalkane compounds
Prior art date: 2003-03-05

Application number

ZA200506790A

Other languages

English (en)

Inventor

Jeffrey D Schmitt

Arielle Genevois-Borella

Michael Cheve

Gary M Dull

Marc Capet

Original Assignee

Targacet Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-05

Filing date

2005-08-24

Publication date

2006-05-31

2005-08-24 Application filed by Targacet Inc filed Critical Targacet Inc

2006-05-31 Publication of ZA200506790B publication Critical patent/ZA200506790B/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Psychology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Anesthesiology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA200506790A 2003-03-05 2005-08-24 Arylvinylazacycloalkane compounds and method of preparation and use thereof ZA200506790B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10/379,868 US7098331B2 (en)	2003-03-05	2003-03-05	Arylvinylazacycloalkane compounds and methods of preparation and use thereof

Publications (1)

Publication Number	Publication Date
ZA200506790B true ZA200506790B (en)	2006-05-31

Family

ID=32926772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200506790A ZA200506790B (en)	2003-03-05	2005-08-24	Arylvinylazacycloalkane compounds and method of preparation and use thereof

Country Status (32)

Country	Link
US (8)	US7098331B2 (pl)
EP (3)	EP2085395B1 (pl)
JP (3)	JP4663627B2 (pl)
KR (4)	KR100953150B1 (pl)
CN (3)	CN100526308C (pl)
AR (3)	AR043469A1 (pl)
AT (3)	ATE517893T1 (pl)
AU (3)	AU2004217903B2 (pl)
BR (1)	BRPI0409576A (pl)
CA (1)	CA2516514C (pl)
CL (1)	CL2004000452A1 (pl)
CY (2)	CY1110391T1 (pl)
DE (2)	DE602004031165D1 (pl)
DK (2)	DK1601670T3 (pl)
EA (3)	EA019240B1 (pl)
ES (3)	ES2309507T3 (pl)
GT (1)	GT200400033A (pl)
HK (3)	HK1084949A1 (pl)
IL (3)	IL170155A (pl)
JO (1)	JO2488B1 (pl)
MX (1)	MXPA05009386A (pl)
NO (3)	NO331920B1 (pl)
NZ (1)	NZ541795A (pl)
PA (1)	PA8597201A1 (pl)
PE (1)	PE20040930A1 (pl)
PL (5)	PL1601670T3 (pl)
PT (2)	PT1601670E (pl)
SI (2)	SI1601670T1 (pl)
TW (3)	TWI339662B (pl)
UY (1)	UY28218A1 (pl)
WO (1)	WO2004078752A1 (pl)
ZA (1)	ZA200506790B (pl)

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US7098331B2 (en) *	2003-03-05	2006-08-29	Targacept, Inc.	Arylvinylazacycloalkane compounds and methods of preparation and use thereof
FR2896800B1 (fr) *	2006-01-30	2008-04-11	Servier Lab	Nouveaux composes pyridinylaminoalkylene-et pyridinyloxyalkylene-cyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
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EP2296640A1 (en) *	2008-05-12	2011-03-23	Targacept Inc.	Methods for preventing the development of retinopathy by the oral administration of nnr ligands
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WO2010080757A2 (en)	2009-01-07	2010-07-15	Astrazeneca Ab	Combinations with an alpha-4beta-2 nicotinic agonist
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AU2010328419A1 (en)	2009-12-07	2012-06-21	Targacept, Inc.	3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands
CA2792157A1 (en) *	2010-03-11	2011-09-15	Targacept, Inc.	Arylvinylazacycloalkane compounds for constipation
US20110274628A1 (en) *	2010-05-07	2011-11-10	Borschke August J	Nicotine-containing pharmaceutical compositions
US20140081714A1 (en) *	2012-09-19	2014-03-20	Salesforce.Com, Inc.	Systems and methods of rewarding users in an on-demand system
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MX2018012230A (es)	2016-04-07	2019-03-28	Oyster Point Pharma Inc	Métodos para tratar enfermedades oculares.
KR101848601B1 (ko) *	2016-07-27	2018-04-12	송기봉	일회용 위생 티슈
EP3820443A1 (en)	2018-07-10	2021-05-19	Oyster Point Pharma, Inc.	Combinations of positive allosteric modulators and nicotinic acetylcholine receptor agonists for treating ocular conditions
WO2020014217A1 (en)	2018-07-10	2020-01-16	Oyster Point Pharma, Inc.	Methods of treating ocular conditions
WO2021222230A1 (en)	2020-04-28	2021-11-04	Oyster Point Pharma, Inc.	Local administration of nicotinic acetylcholine receptor agonists for the inhibition of coronavirus infections

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2003
- 2003-03-05 US US10/379,868 patent/US7098331B2/en not_active Expired - Lifetime
2004
- 2004-02-10 TW TW093103017A patent/TWI339662B/zh not_active IP Right Cessation
- 2004-02-10 TW TW098105932A patent/TW200927746A/zh unknown
- 2004-02-10 TW TW098105931A patent/TWI377204B/zh not_active IP Right Cessation
- 2004-03-02 PE PE2004000228A patent/PE20040930A1/es not_active Application Discontinuation
- 2004-03-04 CN CNB2004800060242A patent/CN100526308C/zh not_active Expired - Lifetime
- 2004-03-04 JO JO200422A patent/JO2488B1/en active
- 2004-03-04 AT AT08075106T patent/ATE517893T1/de not_active IP Right Cessation
- 2004-03-04 SI SI200430775T patent/SI1601670T1/sl unknown
- 2004-03-04 PL PL04717398T patent/PL1601670T3/pl unknown
- 2004-03-04 PA PA20048597201A patent/PA8597201A1/es unknown
- 2004-03-04 AU AU2004217903A patent/AU2004217903B2/en not_active Ceased
- 2004-03-04 EA EA200900706A patent/EA019240B1/ru not_active IP Right Cessation
- 2004-03-04 PL PL378415A patent/PL216979B1/pl unknown
- 2004-03-04 EP EP09075124A patent/EP2085395B1/en not_active Expired - Lifetime
- 2004-03-04 BR BRPI0409576-6A patent/BRPI0409576A/pt not_active IP Right Cessation
- 2004-03-04 JP JP2006509059A patent/JP4663627B2/ja not_active Expired - Fee Related
- 2004-03-04 ES ES04717398T patent/ES2309507T3/es not_active Expired - Lifetime
- 2004-03-04 DE DE602004031165T patent/DE602004031165D1/de not_active Expired - Lifetime
- 2004-03-04 PT PT04717398T patent/PT1601670E/pt unknown
- 2004-03-04 PL PL394604A patent/PL215059B1/pl unknown
- 2004-03-04 PL PL394600A patent/PL394600A1/pl unknown
- 2004-03-04 KR KR1020097002099A patent/KR100953150B1/ko not_active IP Right Cessation
- 2004-03-04 CA CA2516514A patent/CA2516514C/en not_active Expired - Lifetime
- 2004-03-04 PT PT09075124T patent/PT2085395E/pt unknown
- 2004-03-04 AT AT09075124T patent/ATE496046T1/de active
- 2004-03-04 KR KR1020127001576A patent/KR20120014236A/ko not_active Application Discontinuation
- 2004-03-04 CN CN2009100048828A patent/CN101550132B/zh not_active Expired - Fee Related
- 2004-03-04 DK DK04717398T patent/DK1601670T3/da active
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2005
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Also Published As

Publication number	Publication date
US8633222B2 (en)	2014-01-21
CN101255155A (zh)	2008-09-03
AR070570A2 (es)	2010-04-21
US7098331B2 (en)	2006-08-29
US20040176348A1 (en)	2004-09-09
NO332293B1 (no)	2012-08-20
KR20090021227A (ko)	2009-02-27
EA200501425A1 (ru)	2006-02-24
PL215059B1 (pl)	2013-10-31
NO20092231L (no)	2005-10-03
TW200927745A (en)	2009-07-01
ES2389106T3 (es)	2012-10-23
CN100526308C (zh)	2009-08-12
US7714001B2 (en)	2010-05-11
EP1601670B1 (en)	2008-05-07
CN101550132A (zh)	2009-10-07
PL378415A1 (pl)	2006-04-03
US20100267776A1 (en)	2010-10-21
HK1116800A1 (en)	2009-01-02
IL197890A (en)	2013-11-28
EP1947100A1 (en)	2008-07-23
KR101185541B1 (ko)	2012-09-24
EA014714B1 (ru)	2011-02-28
KR20060006006A (ko)	2006-01-18
JP5537084B2 (ja)	2014-07-02
CA2516514A1 (en)	2004-09-16
PT2085395E (pt)	2011-04-20
TW200505909A (en)	2005-02-16
US20150164894A1 (en)	2015-06-18
ATE394394T1 (de)	2008-05-15
JP2009292825A (ja)	2009-12-17
CN101550132B (zh)	2012-03-28
NO20091888L (no)	2005-10-03
AU2008258188B2 (en)	2011-02-24
KR101018083B1 (ko)	2011-03-02
PL394604A1 (pl)	2011-07-18
CL2004000452A1 (es)	2005-05-20
AU2008258188A1 (en)	2009-01-15
TWI377204B (en)	2012-11-21
HK1084949A1 (en)	2006-08-11
ES2385941T3 (es)	2012-08-03
JO2488B1 (en)	2009-10-05
EA200801764A1 (ru)	2008-12-30
KR20120014236A (ko)	2012-02-16
EA010870B1 (ru)	2008-12-30
ATE496046T1 (de)	2011-02-15
US8067443B2 (en)	2011-11-29
NO331920B1 (no)	2012-04-30
PL2085395T3 (pl)	2011-05-31
AU2004217903B2 (en)	2010-03-04
CA2516514C (en)	2012-02-07
NO20054120L (no)	2005-10-03
DE602004013553D1 (de)	2008-06-19
IL197889A (en)	2013-03-24
EA019240B1 (ru)	2014-02-28
EA200900706A1 (ru)	2009-10-30
SI1601670T1 (sl)	2008-10-31
TW200927746A (en)	2009-07-01
US20110152293A1 (en)	2011-06-23
PL216979B1 (pl)	2014-06-30
US20100010042A1 (en)	2010-01-14
AR070569A2 (es)	2010-04-21
CY1110391T1 (el)	2015-04-29
SI2085395T1 (sl)	2011-05-31
PL394600A1 (pl)	2011-07-18
CY1111615T1 (el)	2015-10-07
JP2010001296A (ja)	2010-01-07
US8063068B2 (en)	2011-11-22
TWI339662B (en)	2011-04-01
EP1947100B1 (en)	2011-07-27
AU2008258187B2 (en)	2010-08-05
GT200400033A (es)	2005-05-29
CN1756754A (zh)	2006-04-05
AU2008258187A1 (en)	2009-01-15
PL1601670T3 (pl)	2008-10-31
UY28218A1 (es)	2005-06-30
DK1601670T3 (da)	2008-08-25
IL170155A (en)	2013-08-29
JP4663627B2 (ja)	2011-04-06
KR20090021228A (ko)	2009-02-27
ATE517893T1 (de)	2011-08-15
NZ541795A (en)	2008-03-28
DK2085395T3 (da)	2011-04-18
KR100953150B1 (ko)	2010-04-19
PA8597201A1 (es)	2004-09-28
JP5537085B2 (ja)	2014-07-02
DE602004031165D1 (de)	2011-03-03
EP2085395A1 (en)	2009-08-05
MXPA05009386A (es)	2005-11-04
EP1601670A1 (en)	2005-12-07
AU2004217903A1 (en)	2004-09-16
US20060094732A1 (en)	2006-05-04
US20080293778A1 (en)	2008-11-27
AR043469A1 (es)	2005-07-27
ES2309507T3 (es)	2008-12-16
PE20040930A1 (es)	2005-02-18
BRPI0409576A (pt)	2006-04-18
US20140107164A1 (en)	2014-04-17
EP2085395B1 (en)	2011-01-19
NO20054120D0 (no)	2005-09-05
HK1130254A1 (en)	2009-12-24
PT1601670E (pt)	2008-07-11
JP2006519868A (ja)	2006-08-31
WO2004078752A1 (en)	2004-09-16

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