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ZA200505184B - Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents - Google Patents

Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents Download PDF

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Publication number
ZA200505184B
ZA200505184B ZA200505184A ZA200505184A ZA200505184B ZA 200505184 B ZA200505184 B ZA 200505184B ZA 200505184 A ZA200505184 A ZA 200505184A ZA 200505184 A ZA200505184 A ZA 200505184A ZA 200505184 B ZA200505184 B ZA 200505184B
Authority
ZA
South Africa
Prior art keywords
amino
bromo
phenyl
alkyl
pyrimidinyl
Prior art date
Application number
ZA200505184A
Other languages
English (en)
Inventor
Judi Bryant
Shendong Yuan
Brad Buckman
Ulf Boemer
Peter Esperling
Joachim Kihnke
Lars Wortmann
Emil Eckle
Gary Philllips
Monica Kockanny
Seock-Kyo Khim
Damian Arnaiz
Hans Briem
Christoph Huwe
Martina Schaefer
Dirk Kosemund
Richard Feldman
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA200505184B publication Critical patent/ZA200505184B/en

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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ZA200505184A 2002-11-28 2005-06-27 Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents ZA200505184B (en)

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EP02026607 2002-11-28

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US (1) US7504410B2 (is)
EP (1) EP1565446A1 (is)
JP (1) JP2006508997A (is)
KR (1) KR20050084027A (is)
CN (1) CN1717396A (is)
AU (1) AU2003288198A1 (is)
BR (1) BR0316680A (is)
CA (1) CA2502970A1 (is)
EA (1) EA200500721A1 (is)
EC (1) ECSP055899A (is)
HR (1) HRP20050601A2 (is)
IL (1) IL168102A0 (is)
IS (1) IS7881A (is)
MX (1) MXPA05005547A (is)
NO (1) NO20053144L (is)
NZ (1) NZ539823A (is)
PL (1) PL377795A1 (is)
RS (1) RS20050363A (is)
WO (1) WO2004048343A1 (is)
ZA (1) ZA200505184B (is)

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KR100874791B1 (ko) * 2001-05-29 2008-12-18 바이엘 쉐링 파마 악티엔게젤샤프트 Ｃｄｋ-억제 피리미딘, 그의 제조방법 및 약제로서의 용도
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
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