ZA200409096B - Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins - Google Patents
Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins Download PDFInfo
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- ZA200409096B ZA200409096B ZA200409096A ZA200409096A ZA200409096B ZA 200409096 B ZA200409096 B ZA 200409096B ZA 200409096 A ZA200409096 A ZA 200409096A ZA 200409096 A ZA200409096 A ZA 200409096A ZA 200409096 B ZA200409096 B ZA 200409096B
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- ZA
- South Africa
- Prior art keywords
- hyaluronic acid
- osteogenic
- composition
- bmp
- bone
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- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
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US38159002P | 2002-05-17 | 2002-05-17 |
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ZA200409096A ZA200409096B (en) | 2002-05-17 | 2004-11-10 | Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins |
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US (2) | US20050287135A1 (es) |
EP (1) | EP1519744A4 (es) |
JP (1) | JP4879482B2 (es) |
CN (1) | CN1665525A (es) |
AR (1) | AR039548A1 (es) |
AU (1) | AU2003228958C1 (es) |
BR (1) | BR0310087A (es) |
CA (1) | CA2486113A1 (es) |
CO (1) | CO5631458A2 (es) |
EA (1) | EA008354B1 (es) |
IL (1) | IL165077A0 (es) |
MX (1) | MXPA04011337A (es) |
NO (1) | NO20045507L (es) |
NZ (1) | NZ536478A (es) |
TW (2) | TW200638946A (es) |
WO (1) | WO2003099992A2 (es) |
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Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0608053B1 (en) * | 1993-01-11 | 1999-12-01 | Canon Kabushiki Kaisha | Colour display system |
US7189392B1 (en) * | 1999-10-15 | 2007-03-13 | Genetics Institute, Llc | Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins |
TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
BRPI0413720A (pt) * | 2003-09-12 | 2006-10-17 | Wyeth Corp | bastões e pastas sólidas de fosfato de cálcio injetável para liberação de proteìnas osteogênicas |
CZ13928U1 (cs) * | 2003-10-08 | 2004-01-20 | Cpn Spol. S R.O. | Dietetický přípravek pro prevenci a léčbu osteoporózy |
AR046773A1 (es) * | 2003-12-23 | 2005-12-21 | Novartis Ag | Formulaciones farmaceuticas de bisfosfonatos |
DE602005025977D1 (de) * | 2004-08-23 | 2011-03-03 | Teva Pharma | Kristalline form des ibandronat-natriums und herstellungsverfahren dafür |
ITMI20052515A1 (it) * | 2005-12-29 | 2007-06-30 | Abiogen Pharma Spa | Formulazione farmaceutica per il trattamento della osteoartrite |
EP2019696A1 (en) * | 2006-05-23 | 2009-02-04 | Mathys AG Bettlach | Solid precursor for the preparation of a pasty bone replacement material by admixture of a liquid. |
AU2007304205A1 (en) * | 2006-10-05 | 2008-04-10 | Novartis Ag | Pharmaceutical compositions comprising bisphosphonates |
FR2919188B1 (fr) * | 2007-07-27 | 2010-02-26 | Proteins & Peptides Man | Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps |
EP2288371A1 (fr) * | 2008-04-14 | 2011-03-02 | Adocia | Composition osteogenique comprenant un facteur de croissance un sel soluble de cation et un support organique |
WO2009127940A1 (fr) * | 2008-04-14 | 2009-10-22 | Adocia | Composition osteogenique comprenant un complexe facteur de croissance/polymere amphiphile un sel soluble de cation e un support organique |
EP2360188B1 (en) | 2008-11-05 | 2014-09-17 | National University Corporation Tokyo Medical and Dental University | Hyaluronic acid derivative and pharmaceutical composition thereof |
DK3066996T3 (da) | 2009-07-10 | 2021-08-09 | Implantica Patent Ltd | Hofteledsudstyr |
US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
KR102016745B1 (ko) * | 2013-02-01 | 2019-09-02 | 아이진 주식회사 | Bmp―7 및 부형제를 포함하는 흉터 형성의 감소 또는 억제용 조성물 |
US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
WO2018115879A1 (en) | 2016-12-21 | 2018-06-28 | Mereo Biopharma 3 Limited | Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta |
WO2020051646A1 (en) * | 2018-09-14 | 2020-03-19 | Orthocell Limited | Artificial periosteum |
Family Cites Families (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2465257A (en) * | 1945-09-12 | 1949-03-22 | Universal Moulded Products Cor | Laminated tubular article |
CH563767A5 (es) * | 1973-01-30 | 1975-07-15 | Pheulpin Jean | |
DE2657370C2 (de) * | 1976-12-17 | 1982-11-11 | Hans Dr.med. Dr.med.dent. 8000 München Scheicher | Mittel zum Bedecken und/oder Ausfüllen von Knochendefekten |
DE2732848A1 (de) * | 1977-07-18 | 1979-02-08 | Schering Ag | Diurethane, herbizide mittel enthaltend diese verbindungen sowie verfahren zu ihrer herstellung |
US4455256A (en) * | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
US4727028A (en) * | 1981-06-22 | 1988-02-23 | Eli Lilly And Company | Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof |
US4394370A (en) * | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4434094A (en) * | 1983-04-12 | 1984-02-28 | Collagen Corporation | Partially purified osteogenic factor and process for preparing same from demineralized bone |
US4795804A (en) * | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
US4923805A (en) * | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
GB8334498D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Compounds |
US4804744A (en) * | 1984-01-04 | 1989-02-14 | International Genetic Engineering, Inc. | Osteogenic factors |
US4662884A (en) * | 1984-04-25 | 1987-05-05 | University Of Utah Research Foundation | Prostheses and methods for promoting nerve regeneration |
US4596574A (en) * | 1984-05-14 | 1986-06-24 | The Regents Of The University Of California | Biodegradable porous ceramic delivery system for bone morphogenetic protein |
CA1341617C (en) * | 1984-06-08 | 2011-06-28 | Henry George Burger | Inhibin isolated from ovarian follicular fluid |
ATE128715T1 (de) * | 1984-07-16 | 1995-10-15 | Celtrix Pharma | Polypeptide induzierende faktoren in knochen und knorpel. |
US4843063A (en) * | 1984-07-16 | 1989-06-27 | Collagen Corporation | Polypeptide cartilage-inducing factors found in bone |
US5187263A (en) * | 1984-10-12 | 1993-02-16 | Zymogenetics, Inc. | Expression of biologically active PDGE analogs in eucaryotic cells |
US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
JPS63501471A (ja) * | 1984-12-27 | 1988-06-09 | サントリー株式会社 | インタ−フェロンの精製方法 |
US4681763A (en) * | 1985-06-11 | 1987-07-21 | University Of Medicine And Dentistry Of New Jersey | Composition for stimulating bone growth |
US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
US4798885A (en) * | 1986-02-07 | 1989-01-17 | Genentech, Inc. | Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain |
US5089396A (en) * | 1985-10-03 | 1992-02-18 | Genentech, Inc. | Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
US5215893A (en) * | 1985-10-03 | 1993-06-01 | Genentech, Inc. | Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
US5133755A (en) * | 1986-01-28 | 1992-07-28 | Thm Biomedical, Inc. | Method and apparatus for diodegradable, osteogenic, bone graft substitute device |
US4737578A (en) * | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
US4758233A (en) * | 1986-04-22 | 1988-07-19 | N.J. Phillips TPY. Limited | Cream applicator |
NL8601328A (nl) * | 1986-05-23 | 1987-12-16 | Langen Research | Inrichting voor het met een massa, in het bijzonder pasteuze massa, injekteren van vlees. |
US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
US6432919B1 (en) * | 1986-07-01 | 2002-08-13 | Genetics Institute, Inc. | Bone morphogenetic protein-3 and compositions |
US5459047A (en) * | 1986-07-01 | 1995-10-17 | Genetics Institute, Inc. | BMP-6 proteins |
US5106748A (en) * | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
US5631142A (en) * | 1986-07-01 | 1997-05-20 | Genetics Institute, Inc. | Compositions comprising bone morphogenetic protein-2 (BMP-2) |
US5543394A (en) * | 1986-07-01 | 1996-08-06 | Genetics Institute, Inc. | Bone morphogenetic protein 5(BMP-5) compositions |
US5187076A (en) * | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US5108922A (en) * | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
US5019087A (en) * | 1986-10-06 | 1991-05-28 | American Biomaterials Corporation | Nerve regeneration conduit |
IT1198449B (it) * | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
US5124316A (en) * | 1986-11-14 | 1992-06-23 | President And Fellows Of Harvard College | Method for periodontal regeneration |
US5202120A (en) * | 1987-09-11 | 1993-04-13 | Case Western Reserve University | Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes |
US5011691A (en) * | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
US5258494A (en) * | 1988-04-08 | 1993-11-02 | Stryker Corporation | Osteogenic proteins |
US5108753A (en) * | 1988-04-08 | 1992-04-28 | Creative Biomolecules | Osteogenic devices |
US5024841A (en) * | 1988-06-30 | 1991-06-18 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5284756A (en) * | 1988-10-11 | 1994-02-08 | Lynn Grinna | Heterodimeric osteogenic factor |
US5106626A (en) * | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
US5011486A (en) * | 1988-11-18 | 1991-04-30 | Brown University Research Foundation | Composite nerve guidance channels |
US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
US5162430A (en) * | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
US4920962A (en) * | 1988-11-23 | 1990-05-01 | Claude Proulx | Splint-like element for use in end-to-end nerve suture |
US5217867A (en) * | 1988-11-30 | 1993-06-08 | The Salk Institute For Biological Studies | Receptors: their identification, characterization, preparation and use |
US5202421A (en) * | 1988-12-27 | 1993-04-13 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant substance obtained from urine and process for the preparation thereof |
US5026381A (en) * | 1989-04-20 | 1991-06-25 | Colla-Tec, Incorporated | Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit |
US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
AU5958090A (en) * | 1989-06-29 | 1991-01-17 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1 |
US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US5422340A (en) * | 1989-09-01 | 1995-06-06 | Ammann; Arthur J. | TGF-βformulation for inducing bone growth |
US5236456A (en) * | 1989-11-09 | 1993-08-17 | Osteotech, Inc. | Osteogenic composition and implant containing same |
US5290271A (en) * | 1990-05-14 | 1994-03-01 | Jernberg Gary R | Surgical implant and method for controlled release of chemotherapeutic agents |
WO1991017777A2 (en) | 1990-05-22 | 1991-11-28 | University Of Florida | Injectable bioactive glass compositions and methods for tissue reconstruction |
US5218090A (en) * | 1990-06-12 | 1993-06-08 | Warner-Lambert Company | EGF receptor truncates |
US5206028A (en) * | 1991-02-11 | 1993-04-27 | Li Shu Tung | Dense collagen membrane matrices for medical uses |
US5208219A (en) * | 1991-02-14 | 1993-05-04 | Celtrix Pharmaceuticals Inc. | Method for inducing bone growth |
US5318898A (en) * | 1991-04-02 | 1994-06-07 | Genetics Institute, Inc. | Production of recombinant bone-inducing proteins |
US5118667A (en) * | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
IT1247472B (it) * | 1991-05-31 | 1994-12-17 | Fidia Spa | Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. |
US5216126A (en) * | 1991-06-19 | 1993-06-01 | Genentech, Inc. | Receptor polypeptides and their production and uses |
US6287816B1 (en) * | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
US5356629A (en) * | 1991-07-12 | 1994-10-18 | United States Surgical Corporation | Composition for effecting bone repair |
US5306307A (en) * | 1991-07-22 | 1994-04-26 | Calcitek, Inc. | Spinal disk implant |
ATE238417T1 (de) * | 1991-11-04 | 2003-05-15 | Inst Genetics Llc | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
SE469653B (sv) * | 1992-01-13 | 1993-08-16 | Lucocer Ab | Poroest implantat |
EP0627899B1 (en) * | 1992-02-28 | 2001-11-07 | Cohesion Technologies, Inc. | Injectable ceramic compositions and methods for their preparation and use |
IT1259090B (it) | 1992-04-17 | 1996-03-11 | Fidia Spa | Biomaterialli per protesi d'osso |
IT1259100B (it) * | 1992-05-20 | 1996-03-11 | Lanfranco Callegaro | Uso di idrogeli per il bloccaggio di sistemi protesici |
CZ283073B6 (cs) | 1992-11-03 | 1997-12-17 | Chemickotechnologická Fakulta Stu | Bioaktivní materiál a způsob jeho přípravy |
US6221958B1 (en) * | 1993-01-06 | 2001-04-24 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
US5420243A (en) * | 1993-01-26 | 1995-05-30 | Celtrix Pharmaceuticals, Inc. | Biologically active TGF-β2 peptides |
GB9308060D0 (en) * | 1993-04-19 | 1993-06-02 | Cancer Res Campaign Tech | Stem cell inhibitor |
US5637480A (en) * | 1993-05-12 | 1997-06-10 | Genetics Institute, Inc. | DNA molecules encoding bone morphogenetic protein-10 |
KR100227406B1 (ko) * | 1993-05-12 | 1999-12-01 | 브루스 엠. 에이센 | Bmp-11 조성물 |
DK0716610T3 (da) * | 1993-08-26 | 2006-09-04 | Genetics Inst Llc | Humane knogle-morfogenetiske proteiner til anvendelse ved neural regenerering |
US6027919A (en) * | 1993-12-07 | 2000-02-22 | Genetics Institute, Inc. | BMP-12 and BMP-13 proteins and DNA encoding them |
PT733109E (pt) * | 1993-12-07 | 2006-07-31 | Genetics Inst Llc | Proteinas morfogeneticas dos 0ss0s pmo-12 e pmo-13 e as suas composicoes para inducao de tendao |
US5399677A (en) * | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
ITPD940054A1 (it) * | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
US5520923A (en) * | 1994-09-19 | 1996-05-28 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
US5635372A (en) * | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
ES2203701T3 (es) * | 1995-06-05 | 2004-04-16 | Genetics Institute, Llc | Uso de proteinas morfogenicas de hueso para sanar y reparar uniones de tejido conjuntivo. |
US5716413A (en) * | 1995-10-11 | 1998-02-10 | Osteobiologics, Inc. | Moldable, hand-shapable biodegradable implant material |
US5752974A (en) * | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
IT1282219B1 (it) * | 1995-12-20 | 1998-03-16 | Fidia Advanced Biopolymers Srl | Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa |
NZ331238A (en) * | 1996-03-05 | 2000-05-26 | Orquest Inc | Method of promoting bone growth with hyaluronic acid and growth factors (bFGF) |
JP2002504083A (ja) | 1996-03-05 | 2002-02-05 | オーケスト インコーポレイテッド | ヒアルロン酸および増殖因子による骨の増殖を促進する方法 |
WO1997045532A1 (en) | 1996-05-28 | 1997-12-04 | Brown University Research Foundation | Hyaluronan based biodegradable scaffolds for tissue repair |
IT1288290B1 (it) | 1996-06-21 | 1998-09-11 | Fidia Spa In Amministrazione S | Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie |
EP0957943B2 (en) * | 1997-02-07 | 2008-11-26 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods of use thereof |
US6034062A (en) * | 1997-03-13 | 2000-03-07 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-9 compositions and their uses |
US6015801A (en) * | 1997-07-22 | 2000-01-18 | Merck & Co., Inc. | Method for inhibiting bone resorption |
IT1296689B1 (it) | 1997-11-06 | 1999-07-14 | Fidia Advanced Biopolymers Srl | Derivati esterei dell'acido ialuronico aventi proprieta viscoelastiche e loro uso in campo biomedico-sanitario |
US6630457B1 (en) * | 1998-09-18 | 2003-10-07 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
IT1302534B1 (it) * | 1998-12-21 | 2000-09-05 | Fidia Advanced Biopolymers Srl | Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per |
JP4211108B2 (ja) * | 1999-01-13 | 2009-01-21 | 生化学工業株式会社 | 高粘弾性物質の注入器具 |
US7189392B1 (en) * | 1999-10-15 | 2007-03-13 | Genetics Institute, Llc | Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins |
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- 2003-05-12 CA CA002486113A patent/CA2486113A1/en not_active Abandoned
- 2003-05-12 BR BR0310087-1A patent/BR0310087A/pt not_active IP Right Cessation
- 2003-05-12 TW TW095124486A patent/TW200638946A/zh unknown
- 2003-05-12 TW TW092112842A patent/TWI282283B/zh active
- 2003-05-12 CN CN038160188A patent/CN1665525A/zh active Pending
- 2003-05-12 AU AU2003228958A patent/AU2003228958C1/en not_active Ceased
- 2003-05-12 NZ NZ536478A patent/NZ536478A/en not_active IP Right Cessation
- 2003-05-12 EA EA200401502A patent/EA008354B1/ru not_active IP Right Cessation
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EP1519744A4 (en) | 2007-10-03 |
AU2003228958A1 (en) | 2003-12-12 |
WO2003099992A2 (en) | 2003-12-04 |
EP1519744A2 (en) | 2005-04-06 |
AU2003228958C1 (en) | 2009-01-08 |
EA200401502A1 (ru) | 2005-08-25 |
WO2003099992A3 (en) | 2004-05-27 |
TW200307559A (en) | 2003-12-16 |
AR039548A1 (es) | 2005-02-23 |
NZ536478A (en) | 2008-02-29 |
CA2486113A1 (en) | 2003-12-04 |
US20090181058A1 (en) | 2009-07-16 |
AU2003228958A2 (en) | 2003-12-12 |
BR0310087A (pt) | 2005-08-16 |
TWI282283B (en) | 2007-06-11 |
JP2005532335A (ja) | 2005-10-27 |
US7875590B2 (en) | 2011-01-25 |
IL165077A0 (en) | 2005-12-18 |
NO20045507L (no) | 2004-12-16 |
JP4879482B2 (ja) | 2012-02-22 |
CN1665525A (zh) | 2005-09-07 |
MXPA04011337A (es) | 2005-07-01 |
EA008354B1 (ru) | 2007-04-27 |
AU2003228958B2 (en) | 2008-05-01 |
US20050287135A1 (en) | 2005-12-29 |
CO5631458A2 (es) | 2006-04-28 |
TW200638946A (en) | 2006-11-16 |
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