ZA200210278B - 3-azabicyclo(3.1.0)hexane derivatives useful in therapy. - Google Patents

3-azabicyclo(3.1.0)hexane derivatives useful in therapy.

Info

Publication number: ZA200210278B
Authority: ZA; South Africa
Prior art keywords: azabicyclo; therapy; derivatives useful; hexane derivatives; hexane
Prior art date: 2000-06-23

Application number

ZA200210278A

Inventor

Bernard Joseph Banks

Douglas James Critcher

Ashley Edward Fenwick

Morris David Gethin

Stephen Paul Gibson

Graham Lunn

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2002-12-19

Publication date

2003-12-19

2002-12-19 Application filed by Pfizer filed Critical Pfizer

2003-12-19 Publication of ZA200210278B publication Critical patent/ZA200210278B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Addiction (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Nutrition Science (AREA)
Cardiology (AREA)
Gynecology & Obstetrics (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

ZA200210278A 2000-06-23 2002-12-19 3-azabicyclo(3.1.0)hexane derivatives useful in therapy. ZA200210278B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0015562.2A GB0015562D0 (en)	2000-06-23	2000-06-23	Heterocycles

Publications (1)

Publication Number	Publication Date
ZA200210278B true ZA200210278B (en)	2003-12-19

Family

ID=9894368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200210278A ZA200210278B (en)	2000-06-23	2002-12-19	3-azabicyclo(3.1.0)hexane derivatives useful in therapy.

Country Status (34)

Country	Link
EP (1)	EP1292574A1 (en)
JP (1)	JP2004512263A (en)
KR (1)	KR20040002386A (en)
CN (1)	CN1639121A (en)
AP (1)	AP2002002698A0 (en)
AR (1)	AR028969A1 (en)
AU (1)	AU781837B2 (en)
BG (1)	BG107329A (en)
BR (1)	BR0111867A (en)
CA (1)	CA2412188A1 (en)
CZ (1)	CZ20023967A3 (en)
DO (1)	DOP2001000187A (en)
DZ (1)	DZ3368A1 (en)
EA (1)	EA005117B1 (en)
GB (1)	GB0015562D0 (en)
HR (1)	HRP20020998A2 (en)
HU (1)	HUP0301228A3 (en)
IL (1)	IL153427A0 (en)
IS (1)	IS6637A (en)
MA (1)	MA26915A1 (en)
MX (1)	MXPA02012878A (en)
NO (1)	NO20026168L (en)
NZ (1)	NZ523141A (en)
OA (1)	OA12293A (en)
PA (1)	PA8519401A1 (en)
PE (1)	PE20020253A1 (en)
PL (1)	PL365956A1 (en)
SK (1)	SK17172002A3 (en)
TN (1)	TNSN01094A1 (en)
UA (1)	UA73176C2 (en)
UY (1)	UY26787A1 (en)
WO (1)	WO2001098267A1 (en)
YU (1)	YU91802A (en)
ZA (1)	ZA200210278B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1440059B1 (en)	2001-10-22	2008-04-16	Pfizer Products Inc.	3-azabicyclo(3.1.0)hexane derivatives as opioid receptor antagonists
CA2486000A1 (en) *	2002-05-17	2003-11-27	Merck Patent Gesellschaft Mit Beschraenkter Haftung	Use of compounds that are effective as selective opiate receptor modulators
DE10259245A1 (en)	2002-12-17	2004-07-01	Merck Patent Gmbh	Derivatives of asimadolin with covalently bound acids
SI2070922T1 (en) *	2004-02-23	2011-12-30	Glaxo Group Ltd	Azabicyclo(3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors
GB0507680D0 (en)	2005-04-15	2005-05-25	Glaxo Group Ltd	Compounds
DE602006017543D1 (en) *	2005-06-14	2010-11-25	Glaxo Group Ltd	NEW CONNECTIONS
EP2010518B1 (en)	2006-04-03	2011-02-16	Glaxo Group Limited	Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors
DK2136801T3 (en)	2007-03-30	2012-12-17	Tioga Pharmaceuticals Inc	KAPPA-OPIAT AGONISTS FOR TREATMENT OF DIARY-DOMINANT AND ALTERNATIVE IRRITABLE GAS Syndrome
TWI423801B (en) *	2007-08-27	2014-01-21	Theravance Inc	8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists
EP2995614B8 (en) *	2010-06-11	2018-03-28	Rhodes Technologies Inc.	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
WO2012042539A2 (en)	2010-09-28	2012-04-05	Panacea Biotec Ltd	Novel bicyclic compounds
ES2774349T3 (en) *	2013-11-20	2020-07-20	Sanwa Kagaku Kenkyusho Co	Derived from 3-azabicyclo [3.1.0] hexane and its use for medical purposes
EP3299357A4 (en)	2015-05-20	2018-11-14	Sanwa Kagaku Kenkyusho Co., Ltd.	Crystal of salt of novel 3-azabicyclo[3.1.0]hexane derivative and pharmaceutical use thereof
WO2018152286A1 (en)	2017-02-17	2018-08-23	Trevena, Inc.	7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
AU2018221148B2 (en)	2017-02-17	2022-05-05	Trevena, Inc.	5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
CA3054122A1 (en)	2017-03-02	2018-09-07	Sanwa Kagaku Kenkyusho Co., Ltd.	Therapeutic agent for alcohol use disorders
CN108250088B (en) *	2018-01-04	2020-10-30	四川之江高新材料股份有限公司	Preparation method of N, N, N '-trimethyl-N' -hydroxyethyl bisaminoethylether
CN115825305B (en) *	2022-10-21	2024-09-20	昆明理工大学	Molecularly imprinted solid-phase microextraction fiber and preparation method and application thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3065230A (en) *	1959-03-16	1962-11-20	Burroughs Wellcome Co	Azabicyclohexanes and method of preparing them
PH24752A (en) *	1987-04-16	1990-10-01	Lilly Co Eli	Piperidine opioid antagonists
US5159081A (en) *	1991-03-29	1992-10-27	Eli Lilly And Company	Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (en) *	1993-12-04	1995-06-08	Basf Ag	N-substituted 3-azabicycloalkane derivatives, their preparation and use
PE20001420A1 (en) *	1998-12-23	2000-12-18	Pfizer	CCR5 MODULATORS
TWI244481B (en) *	1998-12-23	2005-12-01	Pfizer	3-azabicyclo[3.1.0]hexane derivatives useful in therapy

2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/en unknown
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/en unknown
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 EP EP01936728A patent/EP1292574A1/en not_active Withdrawn
- 2001-06-07 CA CA002412188A patent/CA2412188A1/en not_active Abandoned
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/en unknown
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/en not_active IP Right Cessation
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/en not_active Application Discontinuation
- 2001-06-07 CN CNA018116086A patent/CN1639121A/en active Pending
- 2001-06-07 PL PL01365956A patent/PL365956A1/en not_active Application Discontinuation
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/en active
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 IL IL15342701A patent/IL153427A0/en unknown
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/en unknown
- 2001-06-07 YU YU91802A patent/YU91802A/en unknown
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 EA EA200201269A patent/EA005117B1/en not_active IP Right Cessation
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/en not_active Withdrawn
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/en not_active Application Discontinuation
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/en unknown
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/en unknown
- 2001-06-21 UY UY26787A patent/UY26787A1/en not_active Application Discontinuation
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/en not_active Application Discontinuation
- 2001-06-21 AR ARP010102957A patent/AR028969A1/en unknown
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/en unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/en unknown
2002
- 2002-11-28 BG BG107329A patent/BG107329A/en unknown
- 2002-11-28 IS IS6637A patent/IS6637A/en unknown
- 2002-12-12 HR HR20020998A patent/HRP20020998A2/en not_active Application Discontinuation
- 2002-12-16 MA MA26955A patent/MA26915A1/en unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/en unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
CZ20023967A3 (en)	2004-02-18
NO20026168D0 (en)	2002-12-20
HRP20020998A2 (en)	2004-02-29
DZ3368A1 (en)	2001-12-27
HUP0301228A2 (en)	2003-08-28
DOP2001000187A (en)	2002-03-30
UA73176C2 (en)	2005-06-15
NZ523141A (en)	2005-06-24
EA200201269A1 (en)	2003-06-26
UY26787A1 (en)	2002-01-31
EA005117B1 (en)	2004-10-28
PE20020253A1 (en)	2002-04-08
YU91802A (en)	2006-05-25
KR20040002386A (en)	2004-01-07
MXPA02012878A (en)	2003-05-14
AP2002002698A0 (en)	2002-12-31
TNSN01094A1 (en)	2005-11-10
WO2001098267A1 (en)	2001-12-27
PA8519401A1 (en)	2002-12-30
NO20026168L (en)	2003-02-18
BG107329A (en)	2003-07-31
AU781837B2 (en)	2005-06-16
SK17172002A3 (en)	2004-09-08
IS6637A (en)	2002-11-28
BR0111867A (en)	2003-07-01
HUP0301228A3 (en)	2005-08-29
IL153427A0 (en)	2003-07-06
JP2004512263A (en)	2004-04-22
MA26915A1 (en)	2004-12-20
AU6259101A (en)	2002-01-02
WO2001098267A8 (en)	2003-02-27
OA12293A (en)	2004-03-18
CA2412188A1 (en)	2001-12-27
EP1292574A1 (en)	2003-03-19
GB0015562D0 (en)	2000-08-16
AR028969A1 (en)	2003-05-28
PL365956A1 (en)	2005-01-24
CN1639121A (en)	2005-07-13

Publication	Publication Date	Title
TW539393U (en)	2003-06-21	089204149
AU2001252135A1 (en)	2001-09-03	Therapeutic agents
IL159890A0 (en)	2004-06-20	Dolastatin 10 derivatives
GB0016787D0 (en)	2000-08-30	Compounds useful in therapy
ZA200210278B (en)	2003-12-19	3-azabicyclo(3.1.0)hexane derivatives useful in therapy.
SG97205A1 (en)	2003-07-18	Super-halo formation in fet's
MXPA03000644A (en)	2003-06-06	Novel indole derivatives and their use as medicaments.
AU4498201A (en)	2001-10-15	Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment ofpain
IL164887A0 (en)	2005-12-18	Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith
IL154675A0 (en)	2003-09-17	N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide
AU2001266939A1 (en)	2002-01-30	Biocidal polyamides and methods
MXPA01011743A (en)	2003-09-05	5 substituted arylpyrimidines.
AU2001273903A1 (en)	2001-10-08	Therapeutic agents
GB0104243D0 (en)	2001-04-11	Floodstoppers 2
GB2358857B (en)	2002-01-16	Coffins
HRP20020971A2 (en)	2005-02-28	4,5-dihydro-thiazo-2-ylamine derivatives and their use as no-inhibitors
GB9916299D0 (en)	1999-09-15	Dogex 1
AU2001296307A1 (en)	2002-04-08	55054, a human metalloprotease and uses therefor
GB0014046D0 (en)	2000-08-02	Compounds useful in therapy
GB0007203D0 (en)	2000-05-17	Supertrowel 2000
AU2001294910A1 (en)	2002-04-15	3-thioxo-(1,2,4)-oxadiazinan-5-one and their use as anti-antherosclerotic agents
AUPQ417599A0 (en)	1999-12-16	Legs 11
GB0028459D0 (en)	2001-01-10	Glor 2
HK1045506A1 (en)	2002-11-29	Oxathiepino 6,5- i b /iÜdihydropyridines, and related compositions and methods
AU2001285370A1 (en)	2002-03-13	50566, human glyoxalase ii related factor and uses thereof