ZA200201383B - Composition for IVF. - Google Patents

Composition for IVF. Download PDF

Info

Publication number: ZA200201383B
Authority: ZA; South Africa
Prior art keywords: mas; composition; weight; preferred; content
Prior art date: 1999-09-16

Application number

ZA200201383A

Other languages

English (en)

Inventor

Andersen Tina Meinertz

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-16

Filing date

2002-02-19

Publication date

2002-11-27

2002-02-19 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2002-11-27 Publication of ZA200201383B publication Critical patent/ZA200201383B/en

Links

239000000203 mixture Substances 0.000 title claims description 40
239000000243 solution Substances 0.000 claims description 40
LFQXEZVYNCBVDO-PBJLWWPKSA-N 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CCC1=C2CC[C@]2(C)[C@@H]([C@@H](CCC=C(C)C)C)CC=C21 LFQXEZVYNCBVDO-PBJLWWPKSA-N 0.000 claims description 33
210000000287 oocyte Anatomy 0.000 claims description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
239000000654 additive Substances 0.000 claims description 10
230000000996 additive effect Effects 0.000 claims description 8
239000007864 aqueous solution Substances 0.000 claims description 8
239000003960 organic solvent Substances 0.000 claims description 5
239000012265 solid product Substances 0.000 claims description 3
230000015556 catabolic process Effects 0.000 claims description 2
102000004169 proteins and genes Human genes 0.000 claims description 2
108090000623 proteins and genes Proteins 0.000 claims description 2
150000001408 amides Chemical class 0.000 claims 1
229930182817 methionine Natural products 0.000 claims 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 34
108091006905 Human Serum Albumin Proteins 0.000 description 24
102000008100 Human Serum Albumin Human genes 0.000 description 24
239000002609 medium Substances 0.000 description 12
239000000047 product Substances 0.000 description 8
150000001875 compounds Chemical class 0.000 description 7
241000699670 Mus sp. Species 0.000 description 6
239000007758 minimum essential medium Substances 0.000 description 6
239000011550 stock solution Substances 0.000 description 6
239000012736 aqueous medium Substances 0.000 description 5
230000008020 evaporation Effects 0.000 description 4
238000001704 evaporation Methods 0.000 description 4
238000009472 formulation Methods 0.000 description 4
238000002156 mixing Methods 0.000 description 4
238000001556 precipitation Methods 0.000 description 4
238000000034 method Methods 0.000 description 3
239000002904 solvent Substances 0.000 description 3
238000003744 In vitro fertilisation Methods 0.000 description 2
239000000470 constituent Substances 0.000 description 2
238000004128 high performance liquid chromatography Methods 0.000 description 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
230000035800 maturation Effects 0.000 description 2
230000021121 meiosis Effects 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
238000012384 transportation and delivery Methods 0.000 description 2
MCKLJFJEQRYRQT-YGDKQAQQSA-N (8s,9s,10r,13s,14s,17s)-17-[(2s)-2-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1C=C2CC(O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@](C)(O)CCCC(C)C)[C@@]1(C)CC2 MCKLJFJEQRYRQT-YGDKQAQQSA-N 0.000 description 1
WQTCTMDKQPZJES-UHFFFAOYSA-N 2-aminoethyl dihydrogen phosphate;nonane Chemical compound NCCOP(O)(O)=O.CCCCCCCCC.CCCCCCCCC WQTCTMDKQPZJES-UHFFFAOYSA-N 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
238000011767 DBA/2J (JAX™ mouse strain) Methods 0.000 description 1
208000034423 Delivery Diseases 0.000 description 1
101100536354 Drosophila melanogaster tant gene Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
108010086677 Gonadotropins Proteins 0.000 description 1
102000006771 Gonadotropins Human genes 0.000 description 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
102000007562 Serum Albumin Human genes 0.000 description 1
108010071390 Serum Albumin Proteins 0.000 description 1
230000004913 activation Effects 0.000 description 1
229940098773 bovine serum albumin Drugs 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
108010006578 follitropin alfa Proteins 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
239000002622 gonadotropin Substances 0.000 description 1
229940094892 gonadotropins Drugs 0.000 description 1
229940057854 gonal f Drugs 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
239000002342 ribonucleoside Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000009210 therapy by ultrasound Methods 0.000 description 1
238000012546 transfer Methods 0.000 description 1
238000011179 visual inspection Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Inorganic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

ZA200201383A 1999-09-16 2002-02-19 Composition for IVF. ZA200201383B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DKPA199901308		1999-09-16

Publications (1)

Publication Number	Publication Date
ZA200201383B true ZA200201383B (en)	2002-11-27

Family

ID=8103409

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200201383A ZA200201383B (en)	1999-09-16	2002-02-19	Composition for IVF.

Country Status (21)

Country	Link
US (1)	US6844313B1 (de)
EP (1)	EP1216059B1 (de)
JP (1)	JP2003509365A (de)
KR (1)	KR100757909B1 (de)
CN (1)	CN1222319C (de)
AT (1)	ATE306942T1 (de)
AU (1)	AU781994B2 (de)
BR (1)	BR0014058A (de)
CA (1)	CA2382908A1 (de)
CZ (1)	CZ2002591A3 (de)
DE (1)	DE60023324T2 (de)
ES (1)	ES2252048T3 (de)
HU (1)	HUP0202630A3 (de)
IL (1)	IL148234A0 (de)
MX (1)	MXPA02002439A (de)
NO (1)	NO323694B1 (de)
PL (1)	PL202224B1 (de)
RU (1)	RU2263516C2 (de)
UA (1)	UA78183C2 (de)
WO (1)	WO2001019354A2 (de)
ZA (1)	ZA200201383B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ20012671A3 (cs) *	1999-02-26	2002-01-16	Novo Nordisk A/S	Způsob in vitro oplodnění s pouľitím kultivačního média obsahujícího sterol aktivující meiosu
ATE306942T1 (de)	1999-09-16	2005-11-15	Novo Nordisk As	Zusammensetzung zur in-vitro befruchtung
WO2001062258A2 (en) *	2000-02-25	2001-08-30	Schering Aktiengesellschaft	Improvement of implantation rate using ff-mas
US6988613B2 (en)	2001-02-06	2006-01-24	Novo Nordisk A/S	Composition for IVF
EP1245572A1 (de)	2001-03-26	2002-10-02	Schering Aktiengesellschaft	Aminosterol-Verbindungen, ihre Verwendung zur Herstellung Meiose-regulierender Medikamenten und ein Vefahren zu ihrer Herstellung

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4175074A (en)	1976-08-23	1979-11-20	Deshmukh Arvind D	Serum-soluble cholesterol compounds and method for their preparation
US4751219A (en)	1985-02-05	1988-06-14	Nederlandse Centrale Organisatie Voor Toegepast-Natuur-Wetenschappelijk Onderzoek	Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides
AU4312489A (en) *	1988-09-23	1990-04-18	Cetus Corporation	Lipid microemulsions for culture media
DE4221880A1 (de)	1992-07-03	1994-01-05	Alfatec Pharma Gmbh	Feste und flüssige Lösungen von schwer wasserlöslichen Arzneistoffen
EP0674506B1 (de) *	1992-12-02	2000-08-23	Alkermes Controlled Therapeutics, Inc.	Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung
US5716777A (en) *	1994-06-23	1998-02-10	Novo Nordisk A/S	Regulation of meiosis using sterols
US6281015B1 (en) *	1994-12-16	2001-08-28	Children's Medical Center Corp.	Localized delivery of factors enhancing survival of transplanted cells
EP0813595A1 (de)	1995-03-06	1997-12-29	Novo Nordisk A/S	Anregung der meiose
CN1191543A (zh)	1995-06-23	1998-08-26	诺沃挪第克公司	减数分裂调控化合物
GB9625175D0 (en) *	1996-12-04	1997-01-22	Medi Cult As	Serum-free cell culture media
IL130249A0 (en) *	1996-12-20	2000-06-01	Novo Nordisk As	Meiosis regulating compounds
KR20010013401A (ko)	1997-06-04	2001-02-26	에프.지.엠. 헤르만스	감수분열 조절용 17β-알릴옥시(티오)알킬-안드로스탄유도체
HUP9701554D0 (en)	1997-09-18	1997-11-28	Human Oltoanyagtermeloe Gyogys	Pharmaceutical composition containing plazma proteins
CA2333320A1 (en)	1998-05-26	1999-12-02	Schering Aktiengesellschaft	Treatment of infertility with camp-increasing compounds alone or in combination with at least one meiosis-stimulating compound
CZ20012671A3 (cs) *	1999-02-26	2002-01-16	Novo Nordisk A/S	Způsob in vitro oplodnění s pouľitím kultivačního média obsahujícího sterol aktivující meiosu
ATE306942T1 (de)	1999-09-16	2005-11-15	Novo Nordisk As	Zusammensetzung zur in-vitro befruchtung

2000
- 2000-09-11 AT AT00958274T patent/ATE306942T1/de not_active IP Right Cessation
- 2000-09-11 MX MXPA02002439A patent/MXPA02002439A/es active IP Right Grant
- 2000-09-11 ES ES00958274T patent/ES2252048T3/es not_active Expired - Lifetime
- 2000-09-11 DE DE60023324T patent/DE60023324T2/de not_active Expired - Fee Related
- 2000-09-11 CZ CZ2002591A patent/CZ2002591A3/cs unknown
- 2000-09-11 CA CA002382908A patent/CA2382908A1/en not_active Abandoned
- 2000-09-11 IL IL14823400A patent/IL148234A0/xx unknown
- 2000-09-11 BR BR0014058-9A patent/BR0014058A/pt not_active Application Discontinuation
- 2000-09-11 EP EP00958274A patent/EP1216059B1/de not_active Expired - Lifetime
- 2000-09-11 JP JP2001522989A patent/JP2003509365A/ja active Pending
- 2000-09-11 HU HU0202630A patent/HUP0202630A3/hu unknown
- 2000-09-11 WO PCT/DK2000/000500 patent/WO2001019354A2/en active IP Right Grant
- 2000-09-11 RU RU2002109794/15A patent/RU2263516C2/ru not_active IP Right Cessation
- 2000-09-11 PL PL353968A patent/PL202224B1/pl not_active IP Right Cessation
- 2000-09-11 AU AU69850/00A patent/AU781994B2/en not_active Ceased
- 2000-09-11 KR KR1020027003526A patent/KR100757909B1/ko not_active IP Right Cessation
- 2000-09-11 CN CNB008128820A patent/CN1222319C/zh not_active Expired - Fee Related
- 2000-09-14 US US09/661,696 patent/US6844313B1/en not_active Expired - Fee Related
- 2000-11-09 UA UA2002032077A patent/UA78183C2/uk unknown
2002
- 2002-02-19 ZA ZA200201383A patent/ZA200201383B/en unknown
- 2002-03-15 NO NO20021309A patent/NO323694B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2382908A1 (en)	2001-03-22
DE60023324D1 (de)	2005-11-24
DE60023324T2 (de)	2006-07-20
HUP0202630A2 (hu)	2002-12-28
JP2003509365A (ja)	2003-03-11
UA78183C2 (en)	2007-03-15
RU2263516C2 (ru)	2005-11-10
EP1216059A2 (de)	2002-06-26
AU6985000A (en)	2001-04-17
CN1222319C (zh)	2005-10-12
AU781994B2 (en)	2005-06-23
ATE306942T1 (de)	2005-11-15
MXPA02002439A (es)	2002-07-30
KR100757909B1 (ko)	2007-09-11
WO2001019354A2 (en)	2001-03-22
BR0014058A (pt)	2004-03-30
IL148234A0 (en)	2002-09-12
HUP0202630A3 (en)	2004-06-28
NO323694B1 (no)	2007-06-25
WO2001019354A3 (en)	2001-06-14
NO20021309D0 (no)	2002-03-15
ES2252048T3 (es)	2006-05-16
NO20021309L (no)	2002-03-15
PL353968A1 (en)	2003-12-15
CN1373675A (zh)	2002-10-09
KR20020032593A (ko)	2002-05-03
US6844313B1 (en)	2005-01-18
EP1216059B1 (de)	2005-10-19
CZ2002591A3 (cs)	2002-08-14
PL202224B1 (pl)	2009-06-30

Publication	Publication Date	Title
CA1326817C (en)	1994-02-08	Promotion of healing of meniscal tissue
EP0509761B1 (de)	1996-09-11	Selegilin enthaltendes transdermales Arzneimittel
US5637309A (en)	1997-06-10	Physiologically active substance-prolonged releasing-type pharmaceutical preparation
EP0420649A2 (de)	1991-04-03	Kleine Peptide enthaltende stabilisierte wässrige Arzneizusammensetzungen
EP0869816B1 (de)	2004-12-15	Trockene zusammensetzungen enthaltend hydrophobe stabilisatoren
BG61267B1 (en)	1997-04-30	Growth hormone crystals and method for production thereof
AU2012288422B2 (en)	2016-08-11	Matrix compositions for controlled release of peptide and polypeptide molecules
AU781994B2 (en)	2005-06-23	Composition for IVF
AU2012288422A1 (en)	2013-12-12	Matrix compositions for controlled release of peptide and polypeptide molecules
US5140010A (en)	1992-08-18	Stabilized aqueous formulations of thymopentin
US6988613B2 (en)	2006-01-24	Composition for IVF
EP1359881A1 (de)	2003-11-12	"verfahren und behältnis mit niedrigem sauerstoffgehalt, das weiterhin mas enthält"
TWI281404B (en)	2007-05-21	Composition for IVF
JPH0733667A (ja)	1995-02-03	４，６−ｏ−ヒドロキシホスホリルグルコサミン誘導体の水溶液及び水溶化方法
Chan Philip et al.	1985	Calmodulin level changes associated with cyclic AMP treatment in cultured squirrel monkey oocytes and sperm.