ZA200209835B - Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or anti-metabolites. - Google Patents

Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or anti-metabolites.

Info

Publication number: ZA200209835B
Authority: ZA; South Africa
Prior art keywords: taxanes; metabolites; distamycin derivatives; acryloyl distamycin; combined therapy
Prior art date: 2000-06-23

Application number

ZA200209835A

Other languages

English (en)

Inventor

Maria Cristina Rosa Geroni

Paolo Cozzi

Italo Beria

Original Assignee

Pharmacia Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2002-12-04

Publication date

2003-12-04

2002-12-04 Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa

2003-12-04 Publication of ZA200209835B publication Critical patent/ZA200209835B/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Epoxy Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA200209835A 2000-06-23 2002-12-04 Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or anti-metabolites. ZA200209835B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0015446.8A GB0015446D0 (en)	2000-06-23	2000-06-23	Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites

Publications (1)

Publication Number	Publication Date
ZA200209835B true ZA200209835B (en)	2003-12-04

Family

ID=9894287

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200209835A ZA200209835B (en)	2000-06-23	2002-12-04	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or anti-metabolites.

Country Status (25)

Country	Link
US (1)	US7642229B2 (xx)
EP (2)	EP1299110B1 (xx)
JP (1)	JP2003535874A (xx)
KR (1)	KR100861668B1 (xx)
CN (1)	CN100479824C (xx)
AT (2)	ATE491457T1 (xx)
AU (2)	AU6755301A (xx)
BR (1)	BR0111814A (xx)
CA (1)	CA2412054A1 (xx)
CZ (1)	CZ20024107A3 (xx)
DE (2)	DE60143681D1 (xx)
EA (1)	EA006709B1 (xx)
EE (1)	EE05359B1 (xx)
ES (1)	ES2317913T3 (xx)
GB (1)	GB0015446D0 (xx)
HK (1)	HK1054506B (xx)
HU (1)	HUP0301334A3 (xx)
IL (2)	IL153178A0 (xx)
MX (1)	MXPA02012165A (xx)
NO (1)	NO329967B1 (xx)
NZ (2)	NZ543318A (xx)
PL (1)	PL200504B1 (xx)
SK (1)	SK287398B6 (xx)
WO (1)	WO2001097618A2 (xx)
ZA (1)	ZA200209835B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070249651A1 (en) *	2001-06-20	2007-10-25	Nerviano Medical Sciences S.R.I.	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
MD36Z (ro) *	2008-12-02	2010-01-31	Василе ЖОВМИР	Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD35Z (ro) *	2008-12-02	2010-01-31	Василе ЖОВМИР	Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
MD24Z (ro) *	2008-12-02	2010-01-31	Василе ЖОВМИР	Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD23Z (ro) *	2008-12-02	2010-01-31	Василе ЖОВМИР	Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE468642B (sv)	1985-07-16	1993-02-22	Erba Farmitalia	Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en)	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents
AU605512B2 (en)	1986-10-07	1991-01-17	Boehringer Mannheim Italia S.P.A.	Pharmaceutical compositions having antineoplastic activity
GB8906709D0 (en)	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja)	1989-09-27	1999-07-19	千寿製薬株式会社	抗腫瘍剤
EP0649307A4 (en) *	1992-07-07	1996-06-26	Sepracor Inc	METHOD FOR USING (-) - CISAPRIDE FOR TREATING GASTIC EYE ELEMENTS AND OTHER DISEASES.
US5633274A (en) *	1993-02-18	1997-05-27	President And Fellows Of Harvard College	Cancer treatments
IT1272234B (it)	1994-05-02	1997-06-16	Consiglio Nazionale Ricerche	Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en)	1994-08-08	1994-09-28	Erba Carlo Spa	Peptidic compounds analogous to distamycin a and process for their preparation
US5597830A (en) *	1994-12-20	1997-01-28	Warner-Lambert Company	Combination chemotherapy
US5880097A (en)	1996-01-04	1999-03-09	Terrapin Techologies, Inc.	Tethered prodrugs
WO1997028123A1 (en)	1996-02-02	1997-08-07	Pharmacia & Upjohn S.P.A.	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9610079D0 (en)	1996-05-14	1996-07-17	Pharmacia Spa	Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en)	1996-07-25	1996-09-04	Pharmacia Spa	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) *	1996-11-11	1997-01-08	Pharmacia & Upjohn Spa	Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en) *	1997-12-31	1998-02-25	Pharmacia & Upjohn Spa	Synergistic antitumor composition containing a biologically active ureido compound
GB9806689D0 (en)	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en)	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9816653D0 (en)	1998-07-30	1998-09-30	Pharmacia & Upjohn Spa	Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816652D0 (en)	1998-07-30	1998-09-30	Pharmacia & Upjohn Spa	Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en)	1999-12-03	2000-02-02	Pharmacia & Upjohn Spa	Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en) *	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
US6576612B1 (en) *	2000-10-02	2003-06-10	Pharmacia Italia S.P.A.	Antitumor therapy comprising distamycin derivatives
US6887851B2 (en) *	2001-09-18	2005-05-03	Bioexpertise, Llc	IGF-binding protein-derived peptide
BR0308976A (pt) *	2002-04-02	2005-01-11	Pharmacia Italia Spa	Terapia combinada contra tumores compreendendo derivados de acriloil distamicina substituìda e radioterapia

2000
- 2000-06-23 GB GBGB0015446.8A patent/GB0015446D0/en not_active Ceased
2001
- 2001-06-20 SK SK1829-2002A patent/SK287398B6/sk not_active IP Right Cessation
- 2001-06-20 AT AT07122497T patent/ATE491457T1/de not_active IP Right Cessation
- 2001-06-20 HU HU0301334A patent/HUP0301334A3/hu unknown
- 2001-06-20 DE DE60143681T patent/DE60143681D1/de not_active Expired - Lifetime
- 2001-06-20 AU AU6755301A patent/AU6755301A/xx active Pending
- 2001-06-20 BR BR0111814-5A patent/BR0111814A/pt not_active Application Discontinuation
- 2001-06-20 MX MXPA02012165A patent/MXPA02012165A/es active IP Right Grant
- 2001-06-20 PL PL363696A patent/PL200504B1/pl not_active IP Right Cessation
- 2001-06-20 DE DE60136706T patent/DE60136706D1/de not_active Expired - Lifetime
- 2001-06-20 JP JP2002503104A patent/JP2003535874A/ja not_active Withdrawn
- 2001-06-20 EA EA200300059A patent/EA006709B1/ru not_active IP Right Cessation
- 2001-06-20 EP EP01945297A patent/EP1299110B1/en not_active Expired - Lifetime
- 2001-06-20 ES ES01945297T patent/ES2317913T3/es not_active Expired - Lifetime
- 2001-06-20 CA CA002412054A patent/CA2412054A1/en not_active Abandoned
- 2001-06-20 US US10/297,620 patent/US7642229B2/en not_active Expired - Fee Related
- 2001-06-20 KR KR1020027017409A patent/KR100861668B1/ko not_active IP Right Cessation
- 2001-06-20 WO PCT/EP2001/007060 patent/WO2001097618A2/en active Application Filing
- 2001-06-20 IL IL15317801A patent/IL153178A0/xx unknown
- 2001-06-20 NZ NZ543318A patent/NZ543318A/en unknown
- 2001-06-20 AU AU2001267553A patent/AU2001267553B2/en not_active Ceased
- 2001-06-20 NZ NZ523001A patent/NZ523001A/en unknown
- 2001-06-20 EP EP07122497A patent/EP1889624B1/en not_active Expired - Lifetime
- 2001-06-20 CZ CZ20024107A patent/CZ20024107A3/cs unknown
- 2001-06-20 AT AT01945297T patent/ATE415165T1/de not_active IP Right Cessation
- 2001-06-20 CN CNB018116078A patent/CN100479824C/zh not_active Expired - Fee Related
- 2001-06-20 EE EEP200200688A patent/EE05359B1/xx not_active IP Right Cessation
2002
- 2002-11-28 IL IL153178A patent/IL153178A/en not_active IP Right Cessation
- 2002-12-04 ZA ZA200209835A patent/ZA200209835B/xx unknown
- 2002-12-18 NO NO20026076A patent/NO329967B1/no not_active IP Right Cessation
2003
- 2003-09-22 HK HK03106774.6A patent/HK1054506B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1437473A (zh)	2003-08-20
EP1889624B1 (en)	2010-12-15
WO2001097618A3 (en)	2002-06-13
BR0111814A (pt)	2003-05-27
KR100861668B1 (ko)	2008-10-07
NO20026076L (no)	2002-12-18
EP1299110B1 (en)	2008-11-26
NO20026076D0 (no)	2002-12-18
WO2001097618A2 (en)	2001-12-27
GB0015446D0 (en)	2000-08-16
AU6755301A (en)	2002-01-02
HK1054506B (zh)	2010-06-11
JP2003535874A (ja)	2003-12-02
ATE415165T1 (de)	2008-12-15
DE60143681D1 (de)	2011-01-27
EA006709B1 (ru)	2006-02-24
KR20030014721A (ko)	2003-02-19
CA2412054A1 (en)	2001-12-27
NZ523001A (en)	2006-07-28
NO329967B1 (no)	2011-01-31
MXPA02012165A (es)	2003-04-25
EE200200688A (et)	2004-06-15
SK287398B6 (sk)	2010-08-09
NZ543318A (en)	2007-11-30
CN100479824C (zh)	2009-04-22
US20040092453A1 (en)	2004-05-13
ES2317913T3 (es)	2009-05-01
US7642229B2 (en)	2010-01-05
ATE491457T1 (de)	2011-01-15
CZ20024107A3 (cs)	2003-05-14
HK1054506A1 (en)	2003-12-05
AU2001267553B2 (en)	2006-02-23
DE60136706D1 (de)	2009-01-08
EP1889624A2 (en)	2008-02-20
PL200504B1 (pl)	2009-01-30
HUP0301334A3 (en)	2005-05-30
EP1889624A3 (en)	2009-02-25
SK18292002A3 (sk)	2003-07-01
IL153178A0 (en)	2003-06-24
EP1299110A2 (en)	2003-04-09
HUP0301334A2 (hu)	2003-08-28
EA200300059A1 (ru)	2003-04-24
EE05359B1 (et)	2010-12-15
PL363696A1 (en)	2004-11-29
IL153178A (en)	2010-11-30

Publication	Publication Date	Title
DE60112974D1 (en)	2005-09-29	Carbolinderivate
GB0025173D0 (en)	2000-11-29	Therapeutic agents
DE60216233D1 (en)	2007-01-04	Carbolinderivate
MXPA03002911A (es)	2003-09-10	Compuestos quimicos.
MXPA02012076A (es)	2003-06-06	Compuestos quimicos.
WO2002070469A3 (en)	2004-03-04	Selective pde3b inhibitors and use of the same in therapy
MXPA03002909A (es)	2003-09-10	Compuestos quimicos.
GB0215526D0 (en)	2002-08-14	Anticancer compounds
AU7846301A (en)	2002-01-02	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase i and ii inhibitors
ZA200209835B (en)	2003-12-04	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or anti-metabolites.
BR0307085A (pt)	2004-12-07	Terapia combinada para o tratamento de infecções bacterianas
PL357179A1 (en)	2004-07-26	Use of 2-methyl-thiazolidin-2,4-dicarboxylic acid (2-mtdc) and/or physiologically compatible salts for treating and/or preventing cancers
MXPA02012209A (es)	2003-06-04	Terapia combinada contra tumores que comprende derivados de bistamicina acriloilo substituida y agentes de alquilacion.
MXPA02012472A (es)	2004-01-26	Compuestos quimicos.
WO2002039958A3 (en)	2002-09-06	Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
CA2445620A1 (en)	2002-12-12	Tetracyclic compounds as pde5-inhibitors
CA2481005A1 (en)	2003-10-09	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy