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ZA200206459B - Amidino compound and salts thereof useful as nitric oxide synthase inhibitors. - Google Patents

Amidino compound and salts thereof useful as nitric oxide synthase inhibitors. Download PDF

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Publication number
ZA200206459B
ZA200206459B ZA200206459A ZA200206459A ZA200206459B ZA 200206459 B ZA200206459 B ZA 200206459B ZA 200206459 A ZA200206459 A ZA 200206459A ZA 200206459 A ZA200206459 A ZA 200206459A ZA 200206459 B ZA200206459 B ZA 200206459B
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ZA
South Africa
Prior art keywords
pharmaceutically
acceptable salt
cation
resin
group
Prior art date
Application number
ZA200206459A
Other languages
English (en)
Inventor
Ronald Keith Webber
Alok K Awasthi
Arija A Bergmanis
Richard C Durley
Scott S Ganser
Timothy J Hagen
E Ann Hallinan
Donald W Hansen Jr
Brian S Hickory
Alan E Moorman
Barnett S Pitzele
Michelle A Promo
Richard R Schartman
Jeffrey S Snyder
Mahima Trivedi
Sofya Tsymbalov
Richard Vonder Embse
Gopichand Yalamanchili
Gary W Phillips
Original Assignee
Pharmacia Corp
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Filing date
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Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of ZA200206459B publication Critical patent/ZA200206459B/en

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    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2402436C (en) * 2000-03-24 2010-02-16 Pharmacia Corporation Amidino compound and salts thereof useful as nitric oxide synthase inhibitors
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7312044B2 (en) 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7012098B2 (en) * 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
AU2002307217A1 (en) 2001-03-28 2002-10-15 University Of South Florida Materials and methods for treatment of cancer and identification of anti-cancer compounds
MY137736A (en) * 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US20030109522A1 (en) * 2001-09-24 2003-06-12 Manning Pamela T. Ophthalmologic treatment methods using selective iNOS inhibitors
US20030119826A1 (en) * 2001-09-24 2003-06-26 Pharmacia Corporation Neuroprotective treatment methods using selective iNOS inhibitors
ATE383156T1 (de) * 2001-11-13 2008-01-15 Pharmacia Corp Oral verabreichbare zusammensetzung enthaltend parecoxib
JP2005532321A (ja) * 2002-05-16 2005-10-27 ファルマシア コーポレーション 呼吸器の疾患および状態の、選択的ｉＮＯＳ阻害剤とＰＤＥ阻害剤による治療方法、ならびにそのための組成物
JP2005536467A (ja) * 2002-05-16 2005-12-02 ファルマシア・コーポレーション 選択的ｉＮＯＳ阻害剤を用いる呼吸器の疾患および状態の治療方法
EP1550725A4 (en) * 2002-06-05 2010-08-25 Kaneka Corp PROCESS FOR PRODUCING OPTICALLY ACTIVE alpha-METHYLCYSTEINE DERIVATIVE
MXPA05001255A (es) * 2002-08-02 2005-06-08 Pharmacia Corp Metodos para el tratamiento y prevencion de condiciones gastrointestinales.
WO2004039772A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Process for preparing s-(2-aminoethyl)-2-methyl-l-cysteine
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
MXPA05006802A (es) * 2002-12-19 2005-09-08 Pharmacia Corp Formulacion no higroscopica que comprende un farmaco higroscopico.
WO2004064767A2 (en) * 2003-01-23 2004-08-05 Kahn Nighat N Nitric oxide inducing agents
DE10308580B3 (de) * 2003-02-27 2004-09-09 Consortium für elektrochemische Industrie GmbH Verfahren zur elektrophilen Substitution von Thiazolidinen oder Oxazolidinen
PT1603872E (pt) * 2003-03-11 2011-06-07 Pharmacia Corp Sal cristalino de cloridrato de maleato de s-[2-[(1- iminoetil) amino]etil-2-metil-l-cisteína
EP1603870A1 (en) * 2003-03-11 2005-12-14 Pharmacia Corporation S- 2- (1-iminoethyl)amino ethyl -2-methyl-l-c ysteine salicylate monohydrate crystalline salt
MXPA05009244A (es) * 2003-03-11 2005-10-19 Pharmacia Corp Procedimientos para la eliminacion selectiva de contraiones de compuestos y compuestos derivados de esos procedimientos.
JP2006519839A (ja) * 2003-03-11 2006-08-31 ファルマシア・コーポレーション Ｓ−［２−［（１−イミノエチル）アミノ］エチル］−２−メチル−ｌ−システインマレエートｉｉ型結晶塩
CA2518737A1 (en) * 2003-03-11 2004-09-23 Pharmacia Corporation S-[2-[(1-iminoethyl)amino]ethyl]-2-methyl-l-cysteine maleate crystalline salt
US20040186046A1 (en) * 2003-03-17 2004-09-23 Pfizer Inc Treatment of type 1 diabetes with PDE5 inhibitors
EP1634957B1 (en) * 2003-04-08 2008-10-08 Mitsubishi Gas Chemical Company, Inc. 2-alkylcysteinamide or salt thereof, process for producing these, and use of these
WO2005049557A1 (ja) * 2003-11-18 2005-06-02 Mitsubishi Gas Chemical Company, Inc. 光学活性２−アルキルシステインの製造方法、並びにその誘導体及び製造方法
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US20060154981A1 (en) * 2005-01-12 2006-07-13 Alcon, Inc. Method of reducing intraocular pressure and treating glaucoma
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20070191490A1 (en) * 2006-02-02 2007-08-16 Sebti Said M Withacnistin compounds for treatment of cancer
US20070219223A1 (en) * 2006-03-07 2007-09-20 Endacea, Inc. Compositions and methods for treating respiratory disorders
WO2007108004A2 (en) * 2006-03-23 2007-09-27 Meditor Pharmaceuticals Ltd. S-alkylisothiouronium derivatives for the treatment of inflammatory diseases
US7820689B2 (en) * 2006-08-10 2010-10-26 Hua-Lin Wu Methods and compositions for preventing or treating cardiovascular disease
CN101758337B (zh) 2009-12-03 2012-02-15 湖南阿斯达生化科技有限公司 一种助焊剂用非卤素活性剂
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
JP6034283B2 (ja) 2010-03-26 2016-11-30 トラスティーズ・オブ・ダートマス・カレッジ Ｖｉｓｔａ制御性ｔ細胞メディエータタンパク質、ｖｉｓｔａ結合剤、およびその使用
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
US9293197B2 (en) 2011-08-15 2016-03-22 Lockheed Martin Corporation Reconfigurable phase change material masks for electro-optical compressive sensing
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
US9381244B2 (en) 2012-09-07 2016-07-05 King's College London VISTA modulators for diagnosis and treatment of cancer
US9340446B1 (en) 2013-02-04 2016-05-17 Lockheed Martin Corporation Optical apparatus and method of forming a gradient index device
WO2014178433A1 (ja) 2013-05-02 2014-11-06 株式会社エーピーアイ コーポレーション α－置換システインもしくはその塩又はα－置換システイン合成中間体の製造方法
US10500176B2 (en) 2013-09-13 2019-12-10 Replicon Health Oy Method for enhancing energy production and metabolism in cells
EP4043493A1 (en) 2013-12-24 2022-08-17 Janssen Pharmaceutica NV Anti-vista antibodies and fragments
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
EP3154585B1 (en) 2014-06-11 2022-02-23 Kathy A. Green Use of vista agonists and antagonists to suppress or enhance humoral immunity
US10437083B1 (en) 2014-10-20 2019-10-08 Lockheed Martin Corporation Individually addressable infrared mask array
WO2016090347A1 (en) 2014-12-05 2016-06-09 Immunext, Inc. Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators
DK3313882T3 (da) 2015-06-24 2020-05-11 Janssen Pharmaceutica Nv Anti-VISTA antistoffer og fragmenter
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds
CN109069626A (zh) 2016-02-12 2018-12-21 詹森药业有限公司 抗-vista(b7h5)抗体
CN118108843A (zh) 2016-04-15 2024-05-31 伊穆奈克斯特股份有限公司 抗人vista抗体及其用途
US9969647B2 (en) 2016-05-17 2018-05-15 Lockheed Martin Energy, Llc Glass composites having a gradient index of refraction and methods for production thereof
US9908808B1 (en) 2016-08-18 2018-03-06 Lockheed Martin Corporation Ternary glass materials with low refractive index variability
EP3398941A1 (en) * 2017-05-03 2018-11-07 AXXAM S.p.A. Heterocyclic p2x7 antagonists

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2036770C (en) 1990-02-26 2003-09-09 Jeffrey P. Whitten Inhibitors of nitric oxide biosynthesis
US5132453A (en) 1991-03-22 1992-07-21 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
GB9127376D0 (en) 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
GB9203347D0 (en) 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
DE4234867A1 (de) * 1992-10-16 1994-04-21 Degussa Verfahren zur Herstellung von Aminoalkylhydantoin und Aminoalkyl-alpha-aminosäuren
IL107771A0 (en) 1992-11-27 1994-02-27 Wellcome Found Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation
WO1994014780A1 (en) 1992-12-18 1994-07-07 The Wellcome Foundation Limited Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
DE4324088A1 (de) * 1993-07-17 1995-01-19 Hoechst Ag Hochtemperatursupraleitende Massivkörper und Verfahren zu ihrer Herstellung
ATE177078T1 (de) 1993-10-21 1999-03-15 Searle & Co Amidino-derivate als no-synthetase inhibitoren
ATE222100T1 (de) 1993-10-21 2002-08-15 Searle & Co Amidino-derivate nützlich als no synthase-hemmer
GB9405211D0 (en) 1994-03-17 1994-04-27 Deas Alexander R Noise cancellation apparatus
PT751930E (pt) 1994-03-24 2000-04-28 Searle & Co Derivados amidino uteis como inibidores da sintetase de oxido nitrico
RU2162841C2 (ru) * 1994-06-15 2001-02-10 Де Вэллкам Фаундейшн Лимитед Производное амидиносульфона, способ его получения (варианты), способ селективного ингибирования изофермента no синтазы, фармацевтический препарат и способ лечения
US5994391A (en) 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US5684008A (en) 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
CN1105706C (zh) 1995-04-20 2003-04-16 G·D·瑟尔公司 用作氧化氮合成酶抑制剂的环状脒基制剂
CN1190390A (zh) 1995-05-10 1998-08-12 G.D.瑟尔公司 由环状脒衍生的氧化氮合成酶抑制剂
GB9516709D0 (en) 1995-08-15 1995-10-18 Zeneca Ltd Medicament
US5830917A (en) 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
MY117948A (en) * 1997-01-13 2004-08-30 Glaxo Group Ltd Nitride oxide synthase inhibitors.
WO1999029865A2 (en) 1997-12-12 1999-06-17 The Rockefeller University A protein belonging to the tnf superfamily, nucleic acids encoding same, and methods of use thereof
CU23047A3 (es) 1998-03-11 2005-04-26 Searle & Co Derivados de aminoacidos halogenados utiles como inhibidores de la oxido nitrico-sintasa.
GB9811599D0 (en) 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
CA2402436C (en) * 2000-03-24 2010-02-16 Pharmacia Corporation Amidino compound and salts thereof useful as nitric oxide synthase inhibitors

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