YU87401A - Derivatives of 4'-demycarosyl-8a-aza-8a-homotylosin - Google Patents
Derivatives of 4'-demycarosyl-8a-aza-8a-homotylosinInfo
- Publication number
- YU87401A YU87401A YU87401A YUP87401A YU87401A YU 87401 A YU87401 A YU 87401A YU 87401 A YU87401 A YU 87401A YU P87401 A YUP87401 A YU P87401A YU 87401 A YU87401 A YU 87401A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- derivatives
- homotylosin
- aza
- demycarosyl
- acyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
Pronalazak se odnosi na derivate 4'-dimikarozil-8a-aza-8a-homotilozina formule I u kojoj R predstavlja CHO, CH(OCH3)2 ili CH2N[CH2(C6H5)]2, R1 predstavlja H ili C1-C3 acil, R2 predstavlja OR6 i R6 predstavlja H ili C1-C3 acil, R3 predstavlja H ili R2 i R3 zajedno predstavljaju = O, R4 predstavlja OH, R5 predstavlja H ili R4 i R5 zajedno predstavljaju = O, i na postupak za njihiovo dobijanje. Novi derivati pokazuju antibakterijsko dejstvo i takodje se mogu koristiti kao intermedijeri za dobijanje novih 17-točlanih azalidnih antibiotika.The invention relates to 4'-dimicarosyl-8a-aza-8a-homotylosin derivatives of formula I in which R represents CHO, CH (OCH3) 2 or CH2N [CH2 (C6H5)] 2, R1 represents H or C1-C3 acyl, R2 represents OR6 and R6 represents H or C1-C3 acyl, R3 represents H or R2 and R3 together represent = O, R4 represents OH, R5 represents H or R4 and R5 together represent = O, and to a process for their preparation. The new derivatives show antibacterial activity and can also be used as intermediates to obtain new 17-point azalide antibiotics.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR990192A HRP990192A2 (en) | 1999-06-11 | 1999-06-11 | 4'-DEMICAROZYL-8a-AZA-8a-HOMOTHILOSINE DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU87401A true YU87401A (en) | 2004-07-15 |
Family
ID=10946940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU87401A YU87401A (en) | 1999-06-11 | 2000-06-06 | Derivatives of 4'-demycarosyl-8a-aza-8a-homotylosin |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1189914A1 (en) |
| JP (1) | JP2003502338A (en) |
| AU (1) | AU767543B2 (en) |
| CA (1) | CA2375812A1 (en) |
| CZ (1) | CZ20014362A3 (en) |
| EA (1) | EA200200026A1 (en) |
| HR (1) | HRP990192A2 (en) |
| HU (1) | HUP0201610A3 (en) |
| NO (1) | NO322424B1 (en) |
| SK (1) | SK17572001A3 (en) |
| UA (1) | UA66930C2 (en) |
| WO (1) | WO2000077016A1 (en) |
| YU (1) | YU87401A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091196B2 (en) | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
| JP2006523229A (en) * | 2003-03-05 | 2006-10-12 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | Bifunctional heterocyclic compounds and methods for their production and use |
| JPWO2005019238A1 (en) | 2003-08-22 | 2006-10-19 | 明治製菓株式会社 | Novel azalides and azalactam derivatives and their production |
| JP5383037B2 (en) | 2004-02-27 | 2014-01-08 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | Macrocyclic compounds and methods of making and using them |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI8710674B (en) * | 1987-04-14 | 1998-06-30 | Pliva | Process for preparation of 10,11,12,13-tetrahydro derivatives of tylosin |
| SI8911498B (en) * | 1989-07-26 | 1998-10-31 | Pliva | Process for the preparation of tylosin derivatives |
| CZ211798A3 (en) * | 1997-07-16 | 1999-02-17 | Pliva, Farmaceutska, Kemijska, Prehrambena I Kozmetička Industrije, Dioničko Društvo | Linear 8a-secoazalides and process for preparing thereof |
-
1999
- 1999-06-11 HR HR990192A patent/HRP990192A2/en not_active Application Discontinuation
-
2000
- 2000-06-06 UA UA2001129085A patent/UA66930C2/en unknown
- 2000-06-06 SK SK1757-2001A patent/SK17572001A3/en unknown
- 2000-06-06 JP JP2001503873A patent/JP2003502338A/en active Pending
- 2000-06-06 CA CA002375812A patent/CA2375812A1/en not_active Abandoned
- 2000-06-06 EP EP00940676A patent/EP1189914A1/en not_active Withdrawn
- 2000-06-06 EA EA200200026A patent/EA200200026A1/en unknown
- 2000-06-06 AU AU55583/00A patent/AU767543B2/en not_active Ceased
- 2000-06-06 CZ CZ20014362A patent/CZ20014362A3/en unknown
- 2000-06-06 HU HU0201610A patent/HUP0201610A3/en unknown
- 2000-06-06 YU YU87401A patent/YU87401A/en unknown
- 2000-06-06 WO PCT/HR2000/000018 patent/WO2000077016A1/en not_active Application Discontinuation
-
2001
- 2001-12-10 NO NO20016030A patent/NO322424B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1189914A1 (en) | 2002-03-27 |
| AU767543B2 (en) | 2003-11-13 |
| AU5558300A (en) | 2001-01-02 |
| JP2003502338A (en) | 2003-01-21 |
| SK17572001A3 (en) | 2002-04-04 |
| HUP0201610A3 (en) | 2003-03-28 |
| HRP990192A2 (en) | 2001-04-30 |
| EA200200026A1 (en) | 2002-06-27 |
| NO20016030D0 (en) | 2001-12-10 |
| NO20016030L (en) | 2002-01-30 |
| HUP0201610A2 (en) | 2002-10-28 |
| CA2375812A1 (en) | 2000-12-21 |
| UA66930C2 (en) | 2004-06-15 |
| WO2000077016A1 (en) | 2000-12-21 |
| CZ20014362A3 (en) | 2002-04-17 |
| NO322424B1 (en) | 2006-10-02 |
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