YU46153B - Postupak za dobivanje grf analoga - Google Patents
Postupak za dobivanje grf analogaInfo
- Publication number
- YU46153B YU46153B YU77185A YU77185A YU46153B YU 46153 B YU46153 B YU 46153B YU 77185 A YU77185 A YU 77185A YU 77185 A YU77185 A YU 77185A YU 46153 B YU46153 B YU 46153B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- arg
- gln
- leu
- ala
- ser
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 125000006239 protecting group Chemical group 0.000 abstract 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 5
- -1 Asp Chemical compound 0.000 abstract 3
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical group CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 239000011347 resin Substances 0.000 abstract 3
- 229920005989 resin Polymers 0.000 abstract 3
- XKCWNEVAXQCMGP-RXMQYKEDSA-N (2R)-2-amino-5-[carbamimidoyl(methyl)amino]pentanoic acid Chemical compound CN(CCC[C@@H](N)C(O)=O)C(N)=N XKCWNEVAXQCMGP-RXMQYKEDSA-N 0.000 abstract 2
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Chemical group OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 2
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 2
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 2
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical group OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003368 amide group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- DCXYFEDJOCDNAF-UWTATZPHSA-N D-Asparagine Chemical group OC(=O)[C@H](N)CC(N)=O DCXYFEDJOCDNAF-UWTATZPHSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical group OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 abstract 1
- 125000003301 D-leucyl group Chemical group N[C@@H](C(=O)*)CC(C)C 0.000 abstract 1
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical group OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 1
- SGCGMORCWLEJNZ-UWVGGRQHSA-N His-His Chemical compound C([C@H]([NH3+])C(=O)N[C@@H](CC=1NC=NC=1)C([O-])=O)C1=CN=CN1 SGCGMORCWLEJNZ-UWVGGRQHSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical group OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- 125000003290 L-leucino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(C([H])([H])[H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000000773 L-serino group Chemical group [H]OC(=O)[C@@]([H])(N([H])*)C([H])([H])O[H] 0.000 abstract 1
- GELXFVQAWNTGPQ-UHFFFAOYSA-N [N].C1=CNC=N1 Chemical group [N].C1=CNC=N1 GELXFVQAWNTGPQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002516 radical scavenger Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Luminescent Compositions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Dental Preparations (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
POSTUPAK ZA DOBIVANJE GRF ANALOG peptida sledeceg niza: Rl-R2-R3-Ala-Ile-Phe-Thr-R8-Ser-Rlo-Arg-Ri2-Ri3- Ri4-Ri5-Gln-Rn-Ri8-Ala-Arg-Lys-Leu-R23-R24-R25- IleR27R28R29-Gln-Gln-GIz-Glu-R34-Asn-Gln-Glu- R38R39R4oArgR42-R43-R44,gde R1 je Tyr,D-Tyr-Met,Phe,D-Phe, pCl-Phe,Leu,His ili D-His koja je nesupstituisana ili C alfa-Me ili N alfa Me supstituisana, R2 je Ala, D-Ala ili D-NMA; R3 je Asp ili D-Asp; R8 je Ser, Asn, D-Ser ili D-Asn; R10 je Tyr ili D-Tyr; R12 je Arg ili Lys; R13 je Ile ili Val; R14 je Leu ili D-Leu; R15 je Gly ili D-Ala; R17 je Leu; ili D-Leu; R18 je Tzr ili Ser; R23 je Leu ili D-Leu; R24 je His ili Gln; R25 je Glu, Asp, D-glu ili D-asp; R27 je Met, D-Met, Ala, Nle, Ile, Leu, Nva ili Val; R28 je Asn ili Ser; R29 je Arg, Ili D-Arg; R34 je Arg, ili Ser; R38 je Gln ili Arg; R39 je Arg ili Gly; R40 je Ser ili Ala; R42 je Phe, Ala ili Val; R43 je Asn ili Arg; R44 je prirodna amino kiselina; pod predpostavkom da neki niz na pocetku C-zavrsetku ili svi ostaci izmedju R28 i R44, ukljucujuci i njih mogu biti izostavljeni i takodje pod predpostavkom da je prisutan bar jedan od sledecih: R2 je D-NMA i/ili R14 je D-Leu i/ili R29 je D-Arg, naznacen time, sto obuhvata: -gradjenje peptida koji ima bar jednu zastitnu grupu i formulu (II): X1-R1(X ili X2)-R2-R3(X3)-Ala-Ile-Phe-Thr(X4)-R8(X4 ili X5)-Ser-(X4)-R10(X2)-Arg(X6)-R12(X6 ili X7)-R13-R14- R15-Gln(X5)-R17-R18(X2)-Ala-Arg(X6)-Lys(X7)-Leu-R23- R24(X ili X5)-R25(X3)-Ile-R27-R28(X4 ili X5)-R29(X6)- Gln(X5)-Gln(X5)-Gly-Glu(X3)-R34(X4 ili X6)-Asn(X5)- Gln(X5)-Glu(X3)-R38(X5 ili X6)-R39(X6)-R40(X4)- Arg(X6)-R42-R43(X5 ili X6)-R44(X8)-X9 ili neke njegove na C-zavrsetku skracene verzije gde: X je vodonik ili zastitna grupa za imidazol azot His-a, pozeljno Tos; X1 je vodonik, acetil ili zastitna grupa za alfa amino grupu, pozeljno BOC; X2 je vodonik ili zastitna grupa za fenolnu hidroksilnu grupu Tyr-a, pozeljno DCB; X3 je vodonik ili pogodna zastitna grupa koja gradi estar za karbok-silnu grupu Asp-a ili Glu-a, pozeljno OBzl; X4 je vodonik ili pogodna zastitna grupa za hidroksilnu grupu Thr-a ili Ser-a, pozeljno Bzl; X5 je vodonik ili pogodna zastitna grupa za amido grupe bocnog lanca Asn-a ili Gln-a, pozeljno Xan; X6 je vodonik ili pogodna zastitna grupa za amido grupu guanidino lanca Arg-a, pozeljno Tos; X7 je vodonik ili pogodna zastitna grupa za amino grupu bocnog lanca Lys-a, pozeljno 2-Cl-Z; X8 je vodonik ili pogodna zastitna grupa za grupe bocnog lanca, kao sto je definisano napred; X9 je veza za nosac smole, posle vezivanja svake amino kiseline koje zapocinje na C-terminusu sa njenom alfa-amino grupom odgovarajuce zasticenom u odnosu od oko 1-2 mmola zasticene amino kiseline na gram smole u pogodnom rastvaracu, pozeljno metilen hloridu ili dimetilformamidu ili njihovoj smesi; i odvajanje zastitnih grupa i skidanje peptida kojl ima bar 27 ostatka u duzini sa pomenutog nosaca smole koristeci TFA u pogodnom rastvaracu, pozeljno CH2Cl2 i/ili koriscenjem HF uz hvatac radikala, pozeljno anizola ili me
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/611,844 US4528190A (en) | 1983-10-25 | 1984-05-18 | GRF Analogs IV |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU77185A YU77185A (en) | 1988-04-30 |
| YU46153B true YU46153B (sh) | 1993-05-28 |
Family
ID=24450622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU77185A YU46153B (sh) | 1984-05-18 | 1985-05-10 | Postupak za dobivanje grf analoga |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4528190A (sh) |
| EP (1) | EP0161852B1 (sh) |
| JP (1) | JPH0689036B2 (sh) |
| KR (1) | KR910000379B1 (sh) |
| AT (1) | ATE73823T1 (sh) |
| AU (1) | AU578467B2 (sh) |
| CA (1) | CA1271299A (sh) |
| DD (1) | DD236536A5 (sh) |
| DE (1) | DE3585634D1 (sh) |
| DK (1) | DK162103C (sh) |
| EG (1) | EG17394A (sh) |
| ES (1) | ES8606412A1 (sh) |
| FI (1) | FI92210C (sh) |
| GR (1) | GR851207B (sh) |
| HU (1) | HU197759B (sh) |
| IE (1) | IE57813B1 (sh) |
| IL (1) | IL75088A (sh) |
| MX (1) | MX157381A (sh) |
| NO (1) | NO168043C (sh) |
| NZ (1) | NZ212113A (sh) |
| PH (1) | PH20976A (sh) |
| PT (1) | PT80450B (sh) |
| SU (1) | SU1530097A3 (sh) |
| YU (1) | YU46153B (sh) |
| ZA (1) | ZA852919B (sh) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4728726A (en) * | 1982-10-04 | 1988-03-01 | The Salk Institute For Biological Studies | GRF analogs IIIb |
| US4732972A (en) * | 1983-03-07 | 1988-03-22 | Hoffmann-La Roche Inc. | Polypeptides having growth hormone releasing activity |
| US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| CA1271600A (en) * | 1985-01-07 | 1990-07-10 | David Howard Coy | Growth hormone-releasing peptides and method of treating mammals therewith |
| EP0193910A3 (en) * | 1985-03-06 | 1988-11-23 | Sumitomo Pharmaceuticals Company, Limited | Synthesis of a derivative of grf and intermediate peptides |
| US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| US4880778A (en) * | 1986-05-12 | 1989-11-14 | Eastman Kodak Company | Combinations having synergistic growth hormone releasing activity and methods for use thereof |
| FR2599038B1 (fr) * | 1986-05-26 | 1990-06-29 | Sanofi Sa | Procede de preparation de nonacosapeptides et peptides intermediaires |
| US5565606A (en) * | 1986-10-21 | 1996-10-15 | Hoechst Aktiengesellschaft | Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method |
| DE3742633A1 (de) * | 1987-12-16 | 1989-06-29 | Hoechst Ag | Peptide mit beeinflussender wirkung auf die hypophyse von saeugern |
| US4843064A (en) * | 1987-01-13 | 1989-06-27 | The Salk Institute For Biological Studies | GRF analogs V |
| IL84758A (en) * | 1987-01-13 | 1992-03-29 | Salk Inst For Biological Studi | Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them |
| US4914189A (en) * | 1987-02-05 | 1990-04-03 | The Adminstrators Of The Tulane Educational Fund | Synthetic GHRH analogs |
| EP0289186A3 (en) * | 1987-04-23 | 1990-04-04 | International Minerals And Chemical Corporation | Process for increasing the growth rate and enhancing the feed efficiency of meat producing livestock |
| US5112808A (en) * | 1987-05-11 | 1992-05-12 | American Cyanamid Company | Alkylated hormone-releasing peptides and method of treatig mammals therewith |
| IL86102A (en) * | 1987-05-11 | 1994-04-12 | Univ Tulane | Alkylated peptides that release growth hormone and their use |
| US5002931A (en) * | 1987-05-22 | 1991-03-26 | The Salk Institute For Biological Studies | GRF analogs VII |
| US4839344A (en) * | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| USRE33699E (en) * | 1987-07-09 | 1991-09-24 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
| US4801456A (en) * | 1987-07-09 | 1989-01-31 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
| US4880777A (en) * | 1987-09-01 | 1989-11-14 | Eastman Kodak Company | Synthetic peptides having growth hormone releasing activity |
| ES2054754T3 (es) * | 1987-09-18 | 1994-08-16 | Hoffmann La Roche | Analogos ciclicos del grf. |
| AU637316B2 (en) * | 1988-01-28 | 1993-05-27 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| US5043322A (en) * | 1988-07-22 | 1991-08-27 | The Salk Institute For Biological Studies | Cyclic GRF analogs |
| US5023322A (en) * | 1988-08-31 | 1991-06-11 | Mta Kutatas-Es Szervezetelemzo Intezete | Analogs of growth hormone releasing factor (GRF) and a method for the preparation thereof |
| US5756458A (en) * | 1989-06-16 | 1998-05-26 | Pharmacia & Upjohn Company | Stabilized potent GRF analogs |
| US5716937A (en) * | 1989-12-13 | 1998-02-10 | The General Hospital Corporation | Method for treating cardiac malfunction |
| ZA914983B (en) * | 1990-06-29 | 1992-03-25 | Hoffmann La Roche | His-grf-analogs |
| EP0490249B1 (en) * | 1990-12-10 | 1995-03-15 | F. Hoffmann-La Roche Ag | Process for the enzymatic preparation of GRF(1-44)NH2 |
| AU662731B2 (en) * | 1991-04-09 | 1995-09-14 | F. Hoffmann-La Roche Ag | Growth hormone releasing factor analogs |
| ZA922746B (en) * | 1991-04-26 | 1992-12-30 | Lilly Co Eli | Superactive grf analogs |
| US5246920A (en) * | 1992-06-15 | 1993-09-21 | University Of South Florida | Treatment of hyperprolactinemia |
| US5811074A (en) * | 1992-06-29 | 1998-09-22 | University Of South Florida | Method of diagnosing pituitary dependent growth hormone deficiency |
| GB9324691D0 (en) * | 1993-12-01 | 1994-01-19 | Hafslund Nycomed As | Peptide compounds |
| US5550212A (en) * | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
| IT1285405B1 (it) * | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
| EA006484B1 (ru) * | 2001-02-02 | 2005-12-29 | Конджачем, Инк. | Долгоживущие производные рилизинг-фактора гормона роста |
| KR20050071498A (ko) * | 2002-09-18 | 2005-07-07 | 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 | 성장 호르몬 방출 호르몬 유사체 |
| US20090088380A1 (en) * | 2007-07-12 | 2009-04-02 | Pierrette Gaudreau | Ghrh analogs and therapeutic uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| IL70530A (en) * | 1983-01-13 | 1986-09-30 | Salk Inst For Biological Studi | Synthetic peptides having growth hormone releasing factor activity and compositions containing them |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
-
1984
- 1984-05-18 US US06/611,844 patent/US4528190A/en not_active Expired - Lifetime
-
1985
- 1985-04-18 ZA ZA852919A patent/ZA852919B/xx unknown
- 1985-04-26 AT AT85302975T patent/ATE73823T1/de not_active IP Right Cessation
- 1985-04-26 DE DE8585302975T patent/DE3585634D1/de not_active Expired - Fee Related
- 1985-04-26 EP EP85302975A patent/EP0161852B1/en not_active Expired - Lifetime
- 1985-04-29 IE IE1087/85A patent/IE57813B1/en not_active IP Right Cessation
- 1985-05-02 CA CA000480584A patent/CA1271299A/en not_active Expired - Fee Related
- 1985-05-03 IL IL75088A patent/IL75088A/xx not_active IP Right Cessation
- 1985-05-08 PH PH32242A patent/PH20976A/en unknown
- 1985-05-09 FI FI851842A patent/FI92210C/fi not_active IP Right Cessation
- 1985-05-10 YU YU77185A patent/YU46153B/sh unknown
- 1985-05-13 PT PT80450A patent/PT80450B/pt not_active IP Right Cessation
- 1985-05-15 NO NO851947A patent/NO168043C/no not_active IP Right Cessation
- 1985-05-15 AU AU42488/85A patent/AU578467B2/en not_active Ceased
- 1985-05-16 EG EG306/85A patent/EG17394A/xx active
- 1985-05-17 DK DK220685A patent/DK162103C/da not_active IP Right Cessation
- 1985-05-17 SU SU853898058A patent/SU1530097A3/ru active
- 1985-05-17 MX MX105337A patent/MX157381A/es unknown
- 1985-05-17 NZ NZ212113A patent/NZ212113A/en unknown
- 1985-05-17 JP JP60105746A patent/JPH0689036B2/ja not_active Expired - Fee Related
- 1985-05-17 HU HU851870A patent/HU197759B/hu not_active IP Right Cessation
- 1985-05-17 KR KR1019850003400A patent/KR910000379B1/ko not_active IP Right Cessation
- 1985-05-17 GR GR851207A patent/GR851207B/el unknown
- 1985-05-17 DD DD85276457A patent/DD236536A5/de not_active IP Right Cessation
- 1985-05-17 ES ES543235A patent/ES8606412A1/es not_active Expired
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