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YU45646B - Postopek za pripravo monoestrov vinske kisline in optično aktivnih alkanolaminov - Google Patents

Postopek za pripravo monoestrov vinske kisline in optično aktivnih alkanolaminov

Info

Publication number
YU45646B
YU45646B YU142784A YU142784A YU45646B YU 45646 B YU45646 B YU 45646B YU 142784 A YU142784 A YU 142784A YU 142784 A YU142784 A YU 142784A YU 45646 B YU45646 B YU 45646B
Authority
YU
Yugoslavia
Prior art keywords
residue
tartaric acid
carbon atoms
general formula
substituted
Prior art date
Application number
YU142784A
Other languages
English (en)
Other versions
YU142784A (en
Inventor
W. Lindner
Original Assignee
Rorer International(Overseas) Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rorer International(Overseas) Inc. filed Critical Rorer International(Overseas) Inc.
Publication of YU142784A publication Critical patent/YU142784A/xx
Publication of YU45646B publication Critical patent/YU45646B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

POSTOPEK ZA PRIPRAVO MONOESTROV VINSKE KISLINE IN OPTIČNO AKTIVNIH ALKANOLAMINOV, s splošno formulo v kateri A stoji za v danem primeru substituiran fenilni, naftiloksimetilni ali indoliloksimetilni ostanek ali predstavlja substituiran feniloksi ostanek s formulo kjer R3 predstavlja metoksietilni ostanek ali ostanek HN-acil, pri čemer je acil definiran kot nižji alkanoilni ostanek z maksimalno 4 atomi ogljika ali kot dialkilkarbamoilni ostanek, v katerem ima alkil 1 ali 2 atoma ogljika in R4 pomeni vodik ali ostanek CH3.CO, R2 pomeni vodik ali razvejen alkilni ostanek s 3 ali 4 atomi ogljika in R1 predstavlja ostanek disubstituirane (R,R) ali (S,S)-vinske kisline s splošno formulo HOOC - CH(OR5) - CH(OR5) - CO - (II) pri čemer R5 pomeni alkilni, aralkilni, v danem primeru substituiran alkanoilni, v danem primeru substituiran aroilni, substituiran vinilni ali N-arilkarbamoilni ostanek, kot tudi njihovih soli s kislinami ali bazami, označen s tem, da zmes optičnih anitipodov s splošno formulo kjer imajo A, R2, R3, R4 in Acil zgoraj navedeni pomen, presnovimo v talini ali v aprotičnem topilu z disubstituirano (R,R)- ali (S,S)-vinsko kislino s splošno formulo HOOC - CH(OR5) - CH(OR5) - COOH (IV) kjer ima R5 zgoraj navedeni pomen, ali njenim anhidridom, s pridržkom, da je pri presnovi s prosto kislino prisotno kondenzacijsko sredstvo, nakar tvorjeno zmes izomernih parov monoestrov vinske kisline s formulo I izoliramo in po želji prevedemo v soli. Prijava vsebuje še 15 patentnih zahtevkov.
YU142784A 1983-08-19 1984-08-16 Postopek za pripravo monoestrov vinske kisline in optično aktivnih alkanolaminov YU45646B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3330005A DE3330005A1 (de) 1983-08-19 1983-08-19 Weinsaeuremonoester von optisch aktiven alkanolaminen, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
YU142784A YU142784A (en) 1988-04-30
YU45646B true YU45646B (sh) 1992-07-20

Family

ID=6206976

Family Applications (1)

Application Number Title Priority Date Filing Date
YU142784A YU45646B (sh) 1983-08-19 1984-08-16 Postopek za pripravo monoestrov vinske kisline in optično aktivnih alkanolaminov

Country Status (22)

Country Link
US (1) US4652672A (sh)
EP (2) EP0145840B1 (sh)
JP (1) JPS6048954A (sh)
AT (2) ATE51614T1 (sh)
AU (1) AU573242B2 (sh)
CA (1) CA1239646A (sh)
CS (1) CS271307B2 (sh)
DD (1) DD231068A1 (sh)
DE (3) DE3330005A1 (sh)
DK (2) DK395884A (sh)
ES (1) ES8601098A1 (sh)
FI (1) FI84910C (sh)
GR (1) GR82176B (sh)
HU (1) HU193587B (sh)
IL (1) IL72634A (sh)
NO (1) NO159083C (sh)
PL (1) PL146074B1 (sh)
PT (1) PT79044B (sh)
RO (1) RO91183B (sh)
SU (1) SU1297723A3 (sh)
YU (1) YU45646B (sh)
ZA (1) ZA846225B (sh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68920797T2 (de) * 1988-08-10 1995-06-29 Otsuka Pharma Co Ltd Herzmittel.
US5198448A (en) * 1988-08-10 1993-03-30 Otsuka Pharmaceutical Company, Limited Cardiotonics
WO1990012794A1 (de) * 1989-04-24 1990-11-01 Noe Christian R Enantiomerenreine am sauerstoff acetalisch geschützte 1,2-aminoalkohole, deren herstellung und verwendung
JPH0674243B2 (ja) * 1989-12-27 1994-09-21 ダイソー株式会社 光学純度の高い光学活性アテノロール塩及びアテノロールの製法
FI93833C (fi) * 1992-05-14 1995-06-12 Orion Yhtymae Oy Menetelmä propionihappojohdosten valmistamiseksi
JPWO2003029199A1 (ja) * 2001-09-28 2005-01-13 武田薬品工業株式会社 ベンゼン誘導体、その製造法および用途
JP2005104895A (ja) * 2003-09-30 2005-04-21 Nippon Kayaku Co Ltd 光学活性なアミノアルコール化合物の製造法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL300886A (sh) * 1962-11-23
US3541130A (en) * 1967-02-06 1970-11-17 Boehringer Sohn Ingelheim 1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes
CH635573A5 (en) * 1977-03-24 1983-04-15 Sandoz Ag Process for preparing novel 1,2-dihydroxypropane derivatives
GB8315495D0 (en) * 1983-06-06 1983-07-13 Sumitomo Chemical Co Fungicidal aniline derivatives

Also Published As

Publication number Publication date
FI843148A0 (fi) 1984-08-10
SU1297723A3 (ru) 1987-03-15
PL249228A1 (en) 1985-05-21
ATE26974T1 (de) 1987-05-15
JPS6048954A (ja) 1985-03-16
GR82176B (sh) 1984-12-13
PT79044B (en) 1986-08-12
PT79044A (en) 1984-09-01
HU193587B (en) 1987-10-28
CS625184A2 (en) 1989-04-14
DK395884D0 (da) 1984-08-17
DK151892A (da) 1992-12-18
AU3176284A (en) 1985-02-21
AU573242B2 (en) 1988-06-02
ATE51614T1 (de) 1990-04-15
NO159083C (no) 1988-11-30
EP0135162B1 (de) 1990-04-04
EP0145840A1 (de) 1985-06-26
EP0135162A3 (en) 1986-04-16
DE3481839D1 (de) 1990-05-10
US4652672A (en) 1987-03-24
IL72634A0 (en) 1984-11-30
ES535243A0 (es) 1985-10-16
DE3463500D1 (en) 1987-06-11
YU142784A (en) 1988-04-30
HUT34949A (en) 1985-05-28
DE3330005A1 (de) 1985-02-28
NO159083B (no) 1988-08-22
FI843148A (fi) 1985-02-20
CA1239646A (en) 1988-07-26
EP0135162A2 (de) 1985-03-27
PL146074B1 (en) 1988-12-31
RO91183B (ro) 1987-07-31
EP0145840B1 (de) 1987-05-06
FI84910C (fi) 1992-02-10
DD231068A1 (de) 1985-12-18
FI84910B (fi) 1991-10-31
ZA846225B (en) 1985-03-27
IL72634A (en) 1987-12-20
RO91183A (ro) 1987-07-30
NO843285L (no) 1985-02-20
CS271307B2 (en) 1990-09-12
DK395884A (da) 1985-02-20
ES8601098A1 (es) 1985-10-16

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