[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

WO2024170365A1 - Composition comprising cyprodinil and lactose-based filler - Google Patents

Composition comprising cyprodinil and lactose-based filler Download PDF

Info

Publication number
WO2024170365A1
WO2024170365A1 PCT/EP2024/052980 EP2024052980W WO2024170365A1 WO 2024170365 A1 WO2024170365 A1 WO 2024170365A1 EP 2024052980 W EP2024052980 W EP 2024052980W WO 2024170365 A1 WO2024170365 A1 WO 2024170365A1
Authority
WO
WIPO (PCT)
Prior art keywords
methyl
composition
composition according
weight
phenyl
Prior art date
Application number
PCT/EP2024/052980
Other languages
French (fr)
Inventor
Aikaterini TSOUTSOURA
Yavuz GOEKCINAR
Gaetano DE MONACO
Original Assignee
Syngenta Crop Protection Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB2302668.5A external-priority patent/GB202302668D0/en
Application filed by Syngenta Crop Protection Ag filed Critical Syngenta Crop Protection Ag
Publication of WO2024170365A1 publication Critical patent/WO2024170365A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings

Definitions

  • the present invention relates to compositions comprising a lactose-based filler, together with method of preparing and using the same.
  • agrochemical formulations has become an important target in the agrochemical field.
  • the target is to develop products with low environmental impact and, as part of this, the presence of and biodegradability of microplastics has become an important topic.
  • the use of granules comprising organic monomers (such as polyurea) and/or cross-linkers is thus undesirable due to their poor biodegradability and classification as microplastics.
  • WGs Water dispersible granules
  • WP wettable powder
  • Cyprodinil is an anilinopyrimidine fungicide that is highly effective against a broad range of fungi and to date has been commercialised as a WG formulation comprising a urea polymer with formaldehyde as a carrier or filler.
  • the terms 'carrier' and 'filler' can be used interchangeably herein.
  • composition must exhibit satisfactory extrusion properties, a lack of residue both during processing and upon the ultimate plant application, effective dispersibility upon mixing with water and good suspension stability in the medium term.
  • the present invention addresses the above technical problems and there is therefore provided a composition
  • a composition comprising cyprodinil and a lactose-based filler.
  • lactose-based filler we include both pure and treated forms of lactose, all crystal and amorphous forms of lactose, as well as both the anhydrous and hydrated forms.
  • the lactose-based filler is lactose monohydrate.
  • the lactose-based filler is present in an amount of from 20 to 50% by weight. Without wishing to be bound by theory, it is thought that the water-solubility properties of such filler reduces the burden on any dispersant and thus leads to advantageous suspension properties.
  • the composition comprises no or substantially no microplastics.
  • substantially no we mean that the composition contains less than 0.01% by weight of the specified material.
  • microplastics we mean synthetic, water-insoluble, non-biodegradable, polymeric materials having a size across its largest dimension of equal to or less than 5 mm.
  • cyprodinil is the sole active ingredient.
  • the composition further comprises fludioxinil.
  • Fludioxonil is a fungicide of the phenylpyrrole group of substances. It is a broad-spectrum fungicide which is non-systemic with a long residual activity and can advantageously be used in combination with cyprodinil.
  • compositions may be in the form of a wettable powder (WP) or a WG (water dispersible granule), preferably water-dispersible granules (WG).
  • WP wettable powder
  • WG water dispersible granule
  • WG water-dispersible granules
  • the cyprodinil is present in an amount of from 30 to 60% by weight.
  • cyprodinil is the sole active ingredient the cyprodinil is preferably present in an amount of from 40 to 60% by weight, such as from 41 to 59% by weight, from 44 to 57% by weight, from 46 to 54% by weight, or even from 48 to 52% by weight.
  • the lactose-based filler is preferably present in an amount of from 31 to 49% by weight, such as from 33 to 48% by weight, from 34 to 47% by weight, from 35 to 46% by weight, from 36 to 45% by weight, or even from 39 to 43% by weight.
  • fludioxinil in the embodiment where fludioxinil is present, it is advantageously present in an amount of from 20 to 30% by weight, such as 21 to 29% by weight, from 22 to 28% by weight, from
  • cyprodinil is preferably present in an amount of from 30 to 50% by weight, such as from 31 to 48% by weight, from 32 to 45% by weight, from 33 to 42% by weight, from 34 to 40% by weight, or even from 35 to 39% by weight.
  • the lactose-based filler is preferably present in an amount of from 20 to 40% by weight, such as from 21 to 38% by weight, from 22 to 36% by weight, from 23 to 34% by weight, from
  • a dispersant or a dispersing agent is typically a surfactant substance, which when added to a suspension of solid particles in a liquid better enables the separation of the particles to avoid their settling or clumping together.
  • the composition comprises one or more dispersants, preferably in an amount of from 0.001 to 10% by weight, or even from 2 to 8% by weight. It is a surprisingly feature of the present invention that a satisfactory technical performance is achieved for the composition despite a low quantity of dispersant.
  • the one or more dispersants are preferably selected from naphthalenesulfonic acid condensate (e.g., formaldehyde condensate) and/or a lignosulphonate.
  • the composition may contain an anti-foaming agent.
  • An anti-foaming agent is a chemical additive that reduces and hinders the formation of foam in a composition, such as a pesticidal formulation.
  • Anti-foaming agents which may be used in accordance with the present invention include, but are not limited to, silicones and polydimethylsiloxanes (e.g., Rhodorsil; XIAMETERTM ACP-1500; Antifoam MSA; Xiameter ACP-0001; Xiameter ACP-0100).
  • the antifoam is preferably present in an amount of from 0.1 to 5% by weight, such as from 1 to 3% by weight.
  • the composition contains no, or substantially no, sodium sulphate, silicium oxide, calcium carbonate, starch, silica and/or polyurea-based polymers.
  • composition demonstrates less than 0.2% residue when tested by the Wet Sieve method defined below.
  • the method of preparation comprises:
  • composition according to the invention is effective against harmful microorganisms, such as microorganisms, that cause phytopathogenic diseases, in particular against phytopathogenic fungi and bacteria
  • a method of controlling or preventing phytopathogenic diseases, especially phytopathogenic fungi, on useful plants or on propagation material thereof which comprises applying to the useful plants, the locus thereof or propagation material thereof a composition as defined.
  • fungicide as used herein means a compound that controls, modifies, or prevents the growth of fungi.
  • fungicidal ly effective amount means the quantity of such a compound or combination of such compounds that is capable of producing an effect on the growth of fungi. Controlling or modifying effects include all deviation from natural development, such as killing, retardation and the like, and prevention includes barrier or other defensive formation in or on a plant to prevent fungal infection.
  • plants refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, stalks, foliage, and fruits.
  • plant propagation material denotes all generative parts of a plant, for example seeds or vegetative parts of plants such as cuttings and tubers. It includes seeds in the strict sense, as well as roots, fruits, tubers, bulbs, rhizomes, and parts of plants.
  • locus means fields in or on which plants are growing, or where seeds of cultivated plants are sown, or where seed will be placed into the soil. It includes soil, seeds, and seedlings, as well as established vegetation.
  • the fungi are selected from one or more of Botrytis, Monilinia, Nectria, Penicillium, Colletotrichum, Fusarium, Gloeosporium, Alternaria, Venturia, Sclerotinia, Stemphylium, Mycosphaerella, and Ascochyta. Even more preferably, when cyprodinil is the sole active ingredient the fungi are selected from Venturia and/or Monilinia. Alternatively, where cyprodinil and fludioxonil are used in combination the fungi are selected from Botrytis, Sclerotinia, Monilinia, Stemphylium and/or Penicillium.
  • the composition as described herein is used on one or more of fresh beans (green, runner, broad), dried beans (dwarf French bean, navy bean (Phaseolus), kidney beans, haricot beans, dried broad beans), vining pea and edible podded pea, dried peas (combining peas including marrowfat), carrots, celeriac, protected and outdoor strawberry, protected and outdoor raspberry and blackberry, outdoor crops of blueberry, bilberry, cranberry, redcurrant, blackcurrant, whitecurrant, gooseberry, and/or top fruit (apple, pear, quince, crab apple).
  • compositions described herein may, in certain circumstances, may be combined with a compound selected from the group of substances consisting of petroleum oils, l,l-bis(4-chloro-phenyl)-2- ethoxyethanol, 2,4-dichlorophenyl benzenesulfonate, 2-fluoro-N-methyl-N-l-naphthylacetamide, 4- chlorophenyl phenyl sulfone, acetoprole, aldoxycarb, amidithion, amidothioate, amiton, amiton hydrogen oxalate, amitraz, aramite, arsenous oxide, azobenzene, azothoate, benomyl, benoxa-fos, benzyl benzoate, bixafen, brofenvalerate, bromo-cyclen, bromophos, bromopropylate, buprofezin, butocarboxim, butoxycarboxim, butylpyr
  • lecontei NPV, Orius spp. Paecilomyces fumosoroseus, Phytoseiulus persimilis, Steinernema bibionis, Steinernema carpocapsae, Steinernema feltiae, Steinernema glaseri, Steinernema riobrave, Steinernema riobravis, Steinernema scapterisci, Steinernema spp., Trichogramma spp., Typhlodromus occidentalis, Verticillium lecanii, apholate, bisazir, busulfan, dimatif, hemel, hempa, metepa, methiotepa, methyl apholate, morzid, penfluron, tepa, thiohempa, thiotepa, tretamine, uredepa, (E)-dec-5-en-l-yl a
  • compositions as described herein have been found to demonstrate superior tankmix stability with one or more of the components listed in Table B below.
  • compositions according to the invention (Compositions 1 and A), together with a broad range of comparative compositions, were prepared with the components as set out in Tables 1 and 3.
  • Cyprodinil is sensitive to temperature in combination with water and a high wet sieve residue can result due to high temperatures during production. The following test was therefore established to establish suitable parameters for commercial product with the limit for a good quality product being ⁇ 0.2% of residue.
  • Samples are stored for two weeks at 54 °C. The tests above are then repeated to determine shelf life and stability. If the Wet Sieve and/or Suspensibility results are very bad the samples were not stored and given an 'NDA' rating.
  • compositions according to the invention demonstrate the necessary combination of technical properties required for a next generation, microplastic-free formulation.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A composition comprising cyprodinil and a lactose-based filler.

Description

COMPOSITION COMPRISING CYPRODINIL AND LACTOSE-BASED FILLER
The present invention relates to compositions comprising a lactose-based filler, together with method of preparing and using the same.
The sustainability of agrochemical formulations has become an important target in the agrochemical field. The target is to develop products with low environmental impact and, as part of this, the presence of and biodegradability of microplastics has become an important topic. The use of granules comprising organic monomers (such as polyurea) and/or cross-linkers is thus undesirable due to their poor biodegradability and classification as microplastics.
Water dispersible granules (WGs) are a solid, non-dusty granular formulation which disperse or dissolve quickly when added to water in the spray tank to give a fine particle suspension. They provide a system for delivering solid active ingredients to a target organism. They allow for the production of highly-concentrated formulations which are wettable and easily disintegrated on contact with water. WGs are an attractive alternative to wettable powder (WP) formulations due to their reduction in dust production, the possibility of high loading of active ingredients and the absence of crystal growth or sedimentation. Package disposal of WG compositions is also easier to deal with than for liquid formulations.
Cyprodinil is an anilinopyrimidine fungicide that is highly effective against a broad range of fungi and to date has been commercialised as a WG formulation comprising a urea polymer with formaldehyde as a carrier or filler. The terms 'carrier' and 'filler' can be used interchangeably herein. There is therefore a pressing technical need for a composition that achieves comparable technical performance and efficacy but which removes microplastics from the product.
Such a product is required to satisfy a significant number of technical and physical properties. The composition must exhibit satisfactory extrusion properties, a lack of residue both during processing and upon the ultimate plant application, effective dispersibility upon mixing with water and good suspension stability in the medium term.
The present invention addresses the above technical problems and there is therefore provided a composition comprising cyprodinil and a lactose-based filler. By 'lactose-based filler' we include both pure and treated forms of lactose, all crystal and amorphous forms of lactose, as well as both the anhydrous and hydrated forms. Preferably the lactose-based filler is lactose monohydrate. Preferably the lactose-based filler is present in an amount of from 20 to 50% by weight. Without wishing to be bound by theory, it is thought that the water-solubility properties of such filler reduces the burden on any dispersant and thus leads to advantageous suspension properties.
Advantageously the composition comprises no or substantially no microplastics. By 'substantially no' we mean that the composition contains less than 0.01% by weight of the specified material.
By 'microplastics' we mean synthetic, water-insoluble, non-biodegradable, polymeric materials having a size across its largest dimension of equal to or less than 5 mm.
In an embodiment, cyprodinil is the sole active ingredient.
In an alternative embodiment, the composition further comprises fludioxinil. Fludioxonil is a fungicide of the phenylpyrrole group of substances. It is a broad-spectrum fungicide which is non-systemic with a long residual activity and can advantageously be used in combination with cyprodinil.
The structures of these components are shown in Table A.
Table A.
Figure imgf000003_0001
Figure imgf000004_0001
The compositions may be in the form of a wettable powder (WP) or a WG (water dispersible granule), preferably water-dispersible granules (WG).
Advantageously, the cyprodinil is present in an amount of from 30 to 60% by weight.
In the embodiment where cyprodinil is the sole active ingredient the cyprodinil is preferably present in an amount of from 40 to 60% by weight, such as from 41 to 59% by weight, from 44 to 57% by weight, from 46 to 54% by weight, or even from 48 to 52% by weight.
In the embodiment where cyprodinil is the sole active ingredient the lactose-based filler is preferably present in an amount of from 31 to 49% by weight, such as from 33 to 48% by weight, from 34 to 47% by weight, from 35 to 46% by weight, from 36 to 45% by weight, or even from 39 to 43% by weight.
Alternatively, in the embodiment where fludioxinil is present, it is advantageously present in an amount of from 20 to 30% by weight, such as 21 to 29% by weight, from 22 to 28% by weight, from
23 to 27% by weight, or even from 24 to 26% by weight. In combination with fludioxinil, cyprodinil is preferably present in an amount of from 30 to 50% by weight, such as from 31 to 48% by weight, from 32 to 45% by weight, from 33 to 42% by weight, from 34 to 40% by weight, or even from 35 to 39% by weight.
In this embodiment the lactose-based filler is preferably present in an amount of from 20 to 40% by weight, such as from 21 to 38% by weight, from 22 to 36% by weight, from 23 to 34% by weight, from
24 to 33% by weight, or even 26 to 31% by weight. A dispersant or a dispersing agent is typically a surfactant substance, which when added to a suspension of solid particles in a liquid better enables the separation of the particles to avoid their settling or clumping together.
Advantageously the composition comprises one or more dispersants, preferably in an amount of from 0.001 to 10% by weight, or even from 2 to 8% by weight. It is a surprisingly feature of the present invention that a satisfactory technical performance is achieved for the composition despite a low quantity of dispersant.
The one or more dispersants are preferably selected from naphthalenesulfonic acid condensate (e.g., formaldehyde condensate) and/or a lignosulphonate.
The composition may contain an anti-foaming agent. An anti-foaming agent is a chemical additive that reduces and hinders the formation of foam in a composition, such as a pesticidal formulation. Anti-foaming agents which may be used in accordance with the present invention include, but are not limited to, silicones and polydimethylsiloxanes (e.g., Rhodorsil; XIAMETERTM ACP-1500; Antifoam MSA; Xiameter ACP-0001; Xiameter ACP-0100). The antifoam is preferably present in an amount of from 0.1 to 5% by weight, such as from 1 to 3% by weight.
Preferably the composition contains no, or substantially no, sodium sulphate, silicium oxide, calcium carbonate, starch, silica and/or polyurea-based polymers.
Advantageously, the composition demonstrates less than 0.2% residue when tested by the Wet Sieve method defined below.
In a second aspect of the invention there is provided a method of preparing a composition as described herein, preferably comprising an extrusion step.
Advantageously, if the composition is in the form of a WG, the method of preparation comprises:
1. Charging of all solid ingredients;
2. Milling of the mixture with a dry mill;
3. Re-homogenization of the milled feedstock;
4. Wetting of the feedstock to produce an extrudable paste; 5. Extrusion through a basket extruder;
6. Drying of the wet extruded granules in a fluid bed dryer; and
7. Sieving the dry extruded granules.
The composition according to the invention is effective against harmful microorganisms, such as microorganisms, that cause phytopathogenic diseases, in particular against phytopathogenic fungi and bacteria
Thus, in a third aspect of the invention there is provided a method of controlling or preventing phytopathogenic diseases, especially phytopathogenic fungi, on useful plants or on propagation material thereof, which comprises applying to the useful plants, the locus thereof or propagation material thereof a composition as defined.
The term "fungicide" as used herein means a compound that controls, modifies, or prevents the growth of fungi. The term "fungicidal ly effective amount" means the quantity of such a compound or combination of such compounds that is capable of producing an effect on the growth of fungi. Controlling or modifying effects include all deviation from natural development, such as killing, retardation and the like, and prevention includes barrier or other defensive formation in or on a plant to prevent fungal infection.
The term "plants" refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, stalks, foliage, and fruits.
The term "plant propagation material" denotes all generative parts of a plant, for example seeds or vegetative parts of plants such as cuttings and tubers. It includes seeds in the strict sense, as well as roots, fruits, tubers, bulbs, rhizomes, and parts of plants.
The term "locus" as used herein means fields in or on which plants are growing, or where seeds of cultivated plants are sown, or where seed will be placed into the soil. It includes soil, seeds, and seedlings, as well as established vegetation.
Preferably the fungi are selected from one or more of Botrytis, Monilinia, Nectria, Penicillium, Colletotrichum, Fusarium, Gloeosporium, Alternaria, Venturia, Sclerotinia, Stemphylium, Mycosphaerella, and Ascochyta. Even more preferably, when cyprodinil is the sole active ingredient the fungi are selected from Venturia and/or Monilinia. Alternatively, where cyprodinil and fludioxonil are used in combination the fungi are selected from Botrytis, Sclerotinia, Monilinia, Stemphylium and/or Penicillium.
Preferably, the composition as described herein is used on one or more of fresh beans (green, runner, broad), dried beans (dwarf French bean, navy bean (Phaseolus), kidney beans, haricot beans, dried broad beans), vining pea and edible podded pea, dried peas (combining peas including marrowfat), carrots, celeriac, protected and outdoor strawberry, protected and outdoor raspberry and blackberry, outdoor crops of blueberry, bilberry, cranberry, redcurrant, blackcurrant, whitecurrant, gooseberry, and/or top fruit (apple, pear, quince, crab apple).
The compositions described herein may, in certain circumstances, may be combined with a compound selected from the group of substances consisting of petroleum oils, l,l-bis(4-chloro-phenyl)-2- ethoxyethanol, 2,4-dichlorophenyl benzenesulfonate, 2-fluoro-N-methyl-N-l-naphthylacetamide, 4- chlorophenyl phenyl sulfone, acetoprole, aldoxycarb, amidithion, amidothioate, amiton, amiton hydrogen oxalate, amitraz, aramite, arsenous oxide, azobenzene, azothoate, benomyl, benoxa-fos, benzyl benzoate, bixafen, brofenvalerate, bromo-cyclen, bromophos, bromopropylate, buprofezin, butocarboxim, butoxycarboxim, butylpyridaben, calcium polysulfide, camphechlor, carbanolate, carbophenothion, cymiazole, chino-methionat, chlorbenside, chlordimeform, chlordimeform hydrochloride, chlorfenethol, chlorfenson, chlorfensulfide, chlorobenzilate, chloromebuform, chloromethiuron, chloropropylate, chlorthiophos, cinerin I, cinerin II, cinerins, closantel, coumaphos, crotamiton, crotoxyphos, cufraneb, cyanthoate, DCPM, DDT, demephion, demephion-O, demephion- S, demeton-methyl, demeton-O, demeton-O-methyl, demeton-S, demeton-S-methyl, demeton-S- methylsulfon, dichlofluanid, dichlorvos, dicliphos, dienochlor, dimefox, dinex, dinex-diclexine, dinocap-4, dinocap-6, dinocton, dino-penton, dinosulfon, dinoterbon, dioxathion, diphenyl sulfone, disulfiram, DNOC, dofenapyn, doramectin, endothion, eprinomectin, ethoate-methyl, etrimfos, fenazaflor, fenbutatin oxide, fenothiocarb, fenpyrad, fen-pyroximate, fenpyrazamine, fenson, fentrifanil, flubenzimine, flucycloxuron, fluenetil, fluorbenside, FMC 1137, formetanate, formetanate hydrochloride, formparanate, gamma-HCH, glyodin, halfenprox, hexadecyl cyclopropanecarboxylate, isocarbophos, jasmolin I, jasmolin II, jodfenphos, lindane, malonoben, mecarbam, mephosfolan, mesulfen, methacrifos, methyl bromide, metolcarb, mexacarbate, milbemycin oxime, mipafox, monocrotophos, morphothion, moxidectin, naled, 4-chloro-2-(2-chloro-2-methyl-propyl)-5-[(6-iodo- 3-pyridyl)methoxy]pyridazin-3-one, nifluridide, nikkomycins, nitrilacarb, nitrilacarb 1:1 zinc chloride complex, omethoate, oxydeprofos, oxydisulfoton, pp'-DDT, parathion, permethrin, phenkapton, phosalone, phosfolan, phosphamidon, polychloroterpenes, polynactins, proclonol, promacyl, propoxur, prothidathion, prothoate, pyrethrin I, pyrethrin II, pyrethrins, pyridaphenthion, pyrimitate, quinalphos, quintiofos, R-1492, phosglycin, rotenone, schradan, sebufos, selamectin, sophamide, SSI- 121, sulfiram, sulfluramid, sulfotep, sulfur, diflovidazin, tau-fluvalinate, TEPP, terbam, tetradifon, tetrasul, thiafenox, thiocarboxime, thiofanox, thiometon, thioquinox, thuringiensin, triamiphos, triarathene, triazophos, triazuron, trifenofos, trinactin, vamidothion, vaniliprole, bethoxazin, copper dioctanoate, copper sulfate, cybutryne, dichlone, dichlorophen, endothal, fentin, hydrated lime, nabam, quinoclamine, quinonamid, simazine, triphenyltin acetate, triphenyltin hydroxide, crufomate, piperazine, thiophanate, chloralose, fenthion, pyridin-4-amine, strychnine, l-hydroxy-lH-pyridine-2- thione, 4-(quinoxalin-2-ylamino)benzenesulfonamide, 8-hydroxyquinoline sulfate, bronopol, copper hydroxide, cresol, dipyrithione, dodicin, fenaminosulf, formaldehyde, hydrargaphen, kasugamycin, kasugamycin hydrochloride hydrate, nickel bis(dimethyldithiocarbamate), nitrapyrin, octhilinone, oxolinic acid, oxytetracycline, potassium hydroxyquinoline sulfate, probenazole, streptomycin, streptomycin sesquisulfate, tecloftalam, thiomersal, Adoxophyes orana GV, Agrobacterium radiobacter, Amblyseius spp., Anagrapha falcifera NPV, Anagrus atomus, Aphelinus abdominalis, Aphidius colemani, Aphidoletes aphidimyza, Autographa californica NPV, Bacillus sphaericus Neide, Beauveria brongniartii, Chrysoperla carnea, Cryptolaemus montrouzieri, Cydia pomonella GV, Dacnusa sibirica, Diglyphus isaea, Encarsia formosa, Eretmocerus eremicus, Heterorhabditis bacteriophora and H. megidis, Hippodamia convergens, Leptomastix dactylopii, Macrolophus caliginosus, Mamestra brassicae NPV, Metaphycus helvolus, Metarhizium anisopliae var. acridum, Metarhizium anisopliae var. anisopliae, Neodiprion sertifer NPV and N. lecontei NPV, Orius spp., Paecilomyces fumosoroseus, Phytoseiulus persimilis, Steinernema bibionis, Steinernema carpocapsae, Steinernema feltiae, Steinernema glaseri, Steinernema riobrave, Steinernema riobravis, Steinernema scapterisci, Steinernema spp., Trichogramma spp., Typhlodromus occidentalis, Verticillium lecanii, apholate, bisazir, busulfan, dimatif, hemel, hempa, metepa, methiotepa, methyl apholate, morzid, penfluron, tepa, thiohempa, thiotepa, tretamine, uredepa, (E)-dec-5-en-l-yl acetate with (E)-dec-5-en-l-ol, (E)-tridec-4-en-l-yl acetate, (E)-6-methylhept-2-en-4-ol, (E,Z)-tetradeca-4,10- dien-l-yl acetate, (Z)-dodec-7-en-l-yl acetate, (Z)-hexadec-ll-enal, (Z)-hexadec-ll-en-l-yl acetate, (Z)-hexadec-13-en-ll-yn-l-yl acetate, (Z)-icos-13-en-10-one, (Z)-tetradec-7-en-l-al, (Z)-tetradec-9- en-l-ol, (Z)-tetradec-9-en-l-yl acetate, (7E,9Z)-dodeca-7,9-dien-l-yl acetate, (9Z,llE)-tetradeca-9,ll- dien-l-yl acetate, (9Z,12E)-tetradeca-9,12-dien-l-yl acetate, 14-methyloctadec-l-ene, 4- methylnonan-5-ol with 4-methylnonan-5-one, alpha-multistriatin, brevicomin, codlelure, codlemone, cuelure, disparlure, dodec-8-en-l-yl acetate, dodec-9-en-l-yl acetate, dodeca-8, 10-dien-l-yl acetate, dominicalure, ethyl 4-methyloctanoate, eugenol, frontalin, grandlure, grandlure I, grandlure II, grandlure III, grandlure IV, hexalure, ipsdienol, ipsenol, japonilure, lineatin, litlure, looplure, medlure, megatomoic acid, methyl eugenol, muscalure, octadeca-2,13-dien-l-yl acetate, octadeca-3,13-dien- 1-yl acetate, orfralure, oryctalure, ostramone, siglure, sordidin, sulcatol, tetradec-ll-en-l-yl acetate, trimedlure, trimedlure A, trimedlure Bl, trimedlure B2, trimedlure C, trunc-call, 2-(octylthio)-ethanol, butopyronoxyl, butoxy(polypropylene glycol), dibutyl adipate, dibutyl phthalate, dibutyl succinate, diethyltoluamide, dimethyl carbate, dimethyl phthalate, ethyl hexanediol, hexamide, methoquin- butyl, methylneodecanamide, oxamate, picaridin, 1-dichloro-l-nitroethane, l,l-dichloro-2,2-bis(4- ethylphenyl)-ethane, 1,2-dichloropropane with 1,3-dichloropropene, l-bromo-2-chloroethane, 2,2,2- trichloro-l-(3,4-dichloro-phenyl)ethyl acetate, 2,2-dichlorovinyl 2-ethylsulfinylethyl methyl phosphate, 2-(l,3-dithiolan-2-yl)phenyl dimethylcarbamate, 2-(2-butoxyethoxy)ethyl thiocyanate, 2- (4,5-dimethyl-l,3-dioxolan-2-yl)phenyl methylcarbamate, 2-(4-chloro-3,5-xylyloxy)ethanol, 2- chlorovinyl diethyl phosphate, 2-imidazolidone, 2-isovalerylindan-l, 3-dione, 2-methyl(prop-2- ynyl)aminophenyl methylcarbamate, 2-thiocyanatoethyl laurate, 3-bromo-l-chloroprop-l-ene, 3- methyl-l-phenylpyrazol-5-yl dimethyl-carbamate, 4-methyl(prop-2-ynyl)amino-3,5-xylyl methylcarbamate, 5,5-dimethyl-3-oxocyclohex-l-enyl dimethylcarbamate, acethion, acrylonitrile, aldrin, allosamidin, allyxycarb, alpha-ecdysone, aluminium phosphide, aminocarb, anabasine, athidathion, azamethiphos, Bacillus thuringiensis delta endotoxins, barium hexafluorosilicate, barium polysulfide, barthrin, Bayer 22/190, Bayer 22408, beta-cyfluthrin, beta-cypermethrin, bioethanomethrin, biopermethrin, bis(2-chloroethyl) ether, borax, bromfenvinfos, bromo-DDT, bufencarb, butacarb, butathiofos, butonate, calcium arsenate, calcium cyanide, carbon disulfide, carbon tetrachloride, cartap hydrochloride, cevadine, chlorbicyclen, chlordane, chlordecone, chloroform, chloropicrin, chlorphoxim, chlorprazophos, cis-resmethrin, cismethrin, clocythrin, copper acetoarsenite, copper arsenate, copper oleate, coumithoate, cryolite, CS 708, cyanofenphos, cyanophos, cyclethrin, cythioate, d-tetramethrin, DAEP, dazomet, decarbofuran, diamidafos, dicapthon, dichlofenthion, dicresyl, dicyclanil, dieldrin, diethyl 5-methylpyrazol-3-yl phosphate, dilor, dimefluthrin, dimetan, dimethrin, dimethylvinphos, dimetilan, dinoprop, dinosam, dinoseb, diofenolan, dioxabenzofos, dithicrofos, DSP, ecdysterone, El 1642, EMPC, EPBP, etaphos, ethiofencarb, ethyl formate, ethylene dibromide, ethylene dichloride, ethylene oxide, EXD, fenchlorphos, fenethacarb, fenitrothion, fenoxacrim, fenpirithrin, fensulfothion, fenthion-ethyl, flucofuron, fosmethilan, fospirate, fosthietan, furathiocarb, furethrin, guazatine, guazatine acetates, sodium tetrathiocarbonate, halfenprox, HCH, HEOD, heptachlor, heterophos, HHDN, hydrogen cyanide, hyquincarb, IPSP, isazofos, isobenzan, isodrin, isofenphos, isolane, isoprothiolane, isoxathion, juvenile hormone I, juvenile hormone II, juvenile hormone III, kelevan, kinoprene, lead arsenate, leptophos, lirimfos, lythidathion, m-cumenyl methylcarbamate, magnesium phosphide, mazidox, mecarphon, menazon, mercurous chloride, mesulfenfos, metam, metam-potassium, metam-sodium, methanesulfonyl fluoride, methocrotophos, methoprene, methothrin, methoxychlor, methyl isothiocyanate, methylchloroform, methylene chloride, metoxadiazone, mirex, naftalofos, naphthalene, NC-170, nicotine, nicotine sulfate, nithiazine, nornicotine, O-5-dichloro-4-iodophenyl O- ethyl ethylphosphonothioate, 0,0-diethyl O-4-methyl-2-oxo-2H-chromen-7-yl phosphorothioate, 0,0-diethyl O-6-methyl-2-propylpyrimidin-4-yl phosphorothioate, O,O,O',O'-tetrapropyl dithiopyrophosphate, oleic acid, para-dichlorobenzene, parathion-methyl, pentachlorophenol, pentachlorophenyl laurate, PH 60-38, phenkapton, phosnichlor, phosphine, phoxim-methyl, pirimetaphos, polychlorodicyclopentadiene isomers, potassium arsenite, potassium thiocyanate, precocene I, precocene II, precocene III, primidophos, profluthrin, promecarb, prothiofos, pyrazophos, pyresmethrin, quassia, quinalphos-methyl, quinothion, rafoxanide, resmethrin, rotenone, kadethrin, ryania, ryanodine, sabadilla, schradan, sebufos, SI-0009, thiapronil, sodium arsenite, sodium cyanide, sodium fluoride, sodium hexafluorosilicate, sodium pentachlorophenoxide, sodium selenate, sodium thiocyanate, sulcofuron, sulcofuron-sodium, sulfuryl fluoride, sulprofos, tar oils, tazimcarb, TDE, tebupirimfos, temephos, terallethrin, tetrachloroethane, thicrofos, thiocyclam, thiocyclam hydrogen oxalate, thionazin, thiosultap, thiosultap-sodium, tralomethrin, transpermethrin, triazamate, trichlormetaphos-3, trichloronat, trimethacarb, tolprocarb, triclopyricarb, triprene, veratridine, veratrine, XMC, zetamethrin, zinc phosphide, zolaprofos, meperfluthrin, tetramethylfluthrin, bis(tributyltin) oxide, bromoacetamide, ferric phosphate, niclosamide-olamine, tributyltin oxide, pyrimorph, trifenmorph, l,2-dibromo-3-chloropropane, 1,3-dichloropropene, 3,4- dichlorotetrahydrothio-phene 1,1-dioxide, 3-(4-chlorophenyl)-5-methylrhodanine, 5-methyl-6- thioxo-l,3,5-thiadiazinan-3-ylacetic acid, 6-isopentenylaminopurine, anisiflupurin, benclothiaz, cytokinins, DCIP, furfural, isamidofos, kinetin, Myrothecium verrucaria composition, tetrachlorothiophene, xylenols, zeatin, potassium ethylxanthate, acibenzolar, acibenzolar-S-methyl, Reynoutria sachalinensis extract, alpha-chlorohydrin, antu, barium carbonate, bisthiosemi, brodifacoum, bromadiolone, bromethalin, chlorophacinone, cholecalciferol, coumachlor, coumafuryl, coumatetralyl, crimidine, difenacoum, difethialone, diphacinone, ergocalciferol, flocoumafen, fluoroacetamide, flupropadine, flupropadine hydrochloride, norbormide, phosacetim, phosphorus, pindone, pyrinuron, scilliroside, sodium fluoro-acetate, thallium sulfate, warfarin, 2-(2- butoxyethoxy)-ethyl piperonylate, 5-(l,3-benzodioxol-5-yl)-3-hexylcyclohex-2-enone, farnesol with nerolidol, verbutin, MGK 264, piperonyl butoxide, piprotal, propyl isomer, S421, sesamex, sesasmolin, sulfoxide, anthraquinone, copper naphthenate, copper oxychloride, dicyclopentadiene, thiram, zinc naphthenate, ziram, imanin, ribavirin, chloroinconazide, mercuric oxide, thiophanate-methyl, azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxicon-azole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, furametpyr, hexaconazole, imazalil, imiben-con-azole, ipconazole, metconazole, myclobutanil, paclobutrazole, pefurazoate, penconazole, prothioconazole, pyrifenox, prochloraz, propiconazole, pyrisoxazole, simeconazole, tebucon-azole, tetraconazole, triadimefon, triadime-nol, triflumizole, triticonazole, ancymidol, fenarimol, nuarimol, bupirimate, dimethirimol, ethirimol, dodemorph, fenpropidin, fenpropimorph, spiroxamine, tridemorph, cyprodinil, mepanipyrim, pyrimethanil, fenpiclonil, fludioxonil, benalaxyl, furalaxyl, meta-laxyl, R-metalaxyl, ofurace, oxadixyl, carbendazim, debacarb, fuberidazole, thiaben-dazole, chlozolinate, dichlozoline, myclozoline, procymi-done, vinclozoline, boscalid, carboxin, fenfuram, flutolanil, mepronil, oxycarboxin, penthiopyrad, thifluzamide, dodine, iminoctadine, azoxystrobin, dimoxystrobin, enestroburin, fenaminstrobin, flufenoxystrobin, fluoxastrobin, kresoxim-methyl, metomi-nostrobin, trifloxystrobin, orysastrobin, picoxystrobin, pyraclostrobin, pyrametostrobin, pyraoxystrobin, ferbam, mancozeb, maneb, metiram, propineb, zineb, captafol, captan, fluoroimide, folpet, tolylfluanid, bordeaux mixture, copper oxide, mancopper, oxine-copper, nitrothal-isopropyl, edifenphos, iprobenphos, phosdiphen, tolclofos-methyl, anilazine, benthiavalicarb, blasticidin-S, chloroneb, chloro-tha-lo-nil, cyflufenamid, cymoxanil, cyclobutrifluram, diclocymet, diclomezine, dicloran, diethofencarb, dimetho-morph, flumorph, dithianon, ethaboxam, etridiazole, famoxa-done, fenamidone, fenoxanil, ferimzone, fluazinam, flumetylsulforim, fluopicolide, fluoxytioconazole, flusulfamide, fluxapyroxad, fenhexamid, fos-etyl-aluminium, hymexazol, iprovalicarb, cyazofamid, methasulfo-carb, metrafenone, pencycuron, phthalide, polyoxins, propamocarb, pyribencarb, proquinazid, pyroquilon, pyriofenone, quinoxyfen, quintozene, tiadinil, triazoxide, tricyclazole, triforine, validamycin, valifenalate, zoxamide, mandipropamid, flubeneteram, isopyrazam, sedaxane, benzovindiflupyr, pydiflumetofen, 3-difluoromethyl-l-methyl- lH-pyrazole-4-carboxylic acid (3',4',5'-trifluoro-biphenyl-2-yl)-amide, isoflucypram, isotianil, dipymetitrone, 6-ethyl-5,7-dioxo-pyrrolo[4,5][l,4]dithiino[l,2-c]isothiazole-3-carbonitrile, 2- (difluoromethyl)-N-[3-ethyl-l,l-dimethyl-indan-4-yl]pyridine-3-carboxamide, 4-(2,6-difluorophenyl)- 6-methyl-5-phenyl-pyridazine-3-carbonitrile, (R)-3-(difluoromethyl)-l-methyl-N-[l,l,3- trimethylindan-4-yl]pyrazole-4-carboxamide, 4-(2-bromo-4-fluoro-phenyl)-N-(2-chloro-6-fluoro- phenyl)-2,5-dimethyl-pyrazol-3-amine, 4- (2- bromo- 4- fluorophenyl) - N- (2- chloro- 6- fluorophenyl) - 1, 3- dimethyl- 1H- pyrazol- 5- amine, fluindapyr, coumethoxystrobin (jiaxiangjunzhi), Ivbenmixianan, dichlobentiazox, mandestrobin, 3-(4,4-difluoro-3,4-dihydro-3,3-dimethylisoquinolin-l-yl)quinolone, 2-[2-fluoro-6-[(8-fluoro-2-methyl-3-quinolyl)oxy]phenyl]propan-2-ol, oxathiapiprolin, tert-butyl N-[6- [[[(l-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate, pyraziflumid, inpyrfluxam, trolprocarb, mefentrifluconazole, ipfentrifluconazole, 2-(difluoromethyl)-N-[(3R)-3- ethyl-l,l-dimethyl-indan-4-yl]pyridine-3-carboxamide, N'-(2,5-dimethyl-4-phenoxy-phenyl)-N-ethyl- N-methyl-formamidine, N'-[4-(4,5-dichlorothiazol-2-yl)oxy-2,5-dimethyl-phenyl]-N-ethyl-N-methyl- formamidine, [2-[3-[2-[l-[2-[3,5-bis(difluoromethyl)pyrazol-l-yl]acetyl]-4-piperidyl]thiazol-4-yl]-4,5- dihydroisoxazol-5-yl]-3-chloro-phenyl] methanesulfonate, but-3-ynyl N-[6-[[(Z)-[(l-methyltetrazol-5- yl)-phenyl-methylene]arnino]oxymethyl]-2-pyridyl]carbamate, methyl N-[[5-[4-(2,4- dimethylphenyl)triazol-2-yl]-2-methyl-phenyl]methyl]carbamate, 3-chloro-6-methyl-5-phenyl-4- (2,4,6-trifluorophenyl)pyridazine, pyridachlometyl, 3-(difluoromethyl)-l-methyl-N-[l,l,3- trimethylindan-4-yl]pyrazole-4-carboxamide, l-[2-[[l-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3- methyl-phenyl]-4-methyl-tetrazol-5-one, l-methyl-4-[3-methyl-2-[[2-methyl-4-(3,4,5- trimethylpyrazol-l-yl)phenoxy]methyl]phenyl]tetrazol-5-one, aminopyrifen, ametoctradin, amisulbrom, penflufen, (Z,2E)-5-[l-(4-chlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl- pent-3-enamide, florylpicoxamid, fenpicoxamid, metarylpicoxamid, tebufloquin, ipflufenoquin, quinofumelin, isofetamid, ethyl l-[[4-[[2-(trifluoromethyl)-l,3-dioxolan-2- yl]methoxy]phenyl]methyl]pyrazole-3-carboxylate (may be prepared from the methods described in WO 2020/056090), ethyl l-[[4-[(Z)-2-ethoxy-3,3,3-trifluoro-prop-l-enoxy]phenyl]methyl]pyrazole-3- carboxylate (may be prepared from the methods described in WO 2020/056090), methyl N-[[4-[l-(4- cyclopropyl-2,6-difluoro-phenyl)pyrazol-4-yl]-2-methyl-phenyl]methyl]carbamate (may be prepared from the methods described in WO 2020/097012), methyl N-[[4-[l-(2,6-difluoro-4-isopropyl- phenyl)pyrazol-4-yl]-2-methyl-phenyl]methyl]carbamate (may be prepared from the methods described in WO 2020/097012), N-[2-[2,4-dichloro-phenoxy]phenyl]-3-(difluoromethyl)-l-methyl- pyrazole-4-carboxamide, N-[2-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]-3-(difluoromethyl)-l- methyl-pyrazole-4-carboxamide, benzothiostrobin, phenamacril, 5-amino-l,3,4-thiadiazole-2-thiol zinc salt (2:1), fluopyram, flufenoxadiazam, flutianil, fluopimomide, pyrapropoyne, picarbutrazox, 2- (difluoromethyl)-N-(3-ethyl-l,l-dimethyl-indan-4-yl)pyridine-3-carboxamide, 2- (difluoromethyl) - N- ((3R) - 1, 1, 3- trimethylindan- 4-yl) pyridine- 3- carboxamide, 4-[[6-[2-(2,4-difluorophenyl)-l,l- difluoro-2-hydroxy-3-(l,2,4-triazol-l-yl)propyl]-3-pyridyl]oxy]benzonitrile, metyltetraprole, 2- (difluoromethyl) - N- ((3R) - 1, 1, 3- trimethylindan- 4- yl) pyridine- 3- carboxamide, a- (1, 1- dimethylethyl) - a- [4'- (trifluoromethoxy) [1, 1'- biphenyl] - 4- yl] -5- pyrimidinemethanol, fluoxapiprolin, enoxastrobin, 4-[[6-[2-(2,4-difluorophenyl)-l,l-difluoro-2-hydroxy-3-(l,2,4-triazol-l- yl)propyl]-3-pyridyl]oxy] benzonitrile, 4-[[6-[2-(2,4-difluorophenyl)-l,l-difluoro-2-hydroxy-3-(5- sulfanyl-l,2,4-triazol-l-yl)propyl]-3-pyridyl]oxy] benzonitrile, 4-[[6-[2-(2,4-difluorophenyl)-l,l- difluoro-2-hydroxy-3-(5-thioxo-4H-l,2,4-triazol-l-yl)propyl]-3-pyridyl]oxy]benzonitrile, trinexapac, coumoxystrobin, zhongshengmycin, thiodiazole copper, zinc thiazole, amectotractin, iprodione, seboctylamine, N'-[5-bromo-2-methyl-6-[(lS)-l-methyl-2-propoxy-ethoxy]-3-pyridyl]-N-ethyl-N- methyl-formamidine, N'-[5-bromo-2-methyl-6-[(lR)-l-methyl-2-propoxy-ethoxy]-3-pyridyl]-N-ethyl- N-methyl-formamidine, N'-[5-bromo-2-methyl-6-(l-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N- methyl-formamidine, N'-[5-chloro-2-methyl-6-(l-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N- methyl-formamidine, N'-[5-bromo-2-methyl-6-(l-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-isopropyl- N-methyl-formamidine (these compounds may be prepared from the methods described in WO2015/155075); N'-[5-bromo-2-methyl-6-(2-propoxypropoxy)-3-pyridyl]-N-ethyl-N-methyl- formamidine (this compound may be prepared from the methods described in IPCOM000249876D); N-isopropyl-N'-[5-methoxy-2-methyl-4-(27272-trifluoro-l-hydroxy-l-phenyl-ethyl)phenyl]-N-methyl- formamidine, N'-[4-(l-cyclopropyl-2,2,2-trifluoro-l-hydroxy-ethyl)-5-methoxy-2-methyl-phenyl]-N- isopropyl-N-methyl-formamidine (these compounds may be prepared from the methods described in WO2018/228896); N-ethyl-N'-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)oxetan-2-yl]phenyl]-N- methyl-formamidine, N-ethyl-N'-[5-methoxy-2-methyl-4-[(2-trifuoromethyl)tetrahydrofuran-2- yl]phenyl]-N-methyl-formamidine (these compounds may be prepared from the methods described in W02019/110427); N-[(lR)-l-benzyl-3-chloro-l-methyl-but-3-enyl]-8-fluoro-quinoline-3- carboxamide, N-[(lS)-l-benzyl-3-chloro-l-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N- [(lR)-l-benzyl-3,3,3-trifluoro-l-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(lS)-l-benzyl- 3,3,3-trifluoro-l-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(lR)-l-benzyl-l,3-dimethyl- butyl]-7,8-difluoro-quinoline-3-carboxamide,
N-[(lS)-l-benzyl-l,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(lR)-l-[(3- fluorophenyl)methyl]-l,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(lS)-l-[(3- fluorophenyl)methyl]-l,3-dimethyl-butyl]quinoline-3-carboxamide, N-[(lR)-l-benzyl-l,3-dimethyl- butyl]-8-fluoro-quinoline-3-carboxamide, N-[(lS)-l-benzyl-l,3-dimethyl-butyl]-8-fluoro-quinoline-3- carboxamide,
N-((lR)-l-benzyl-3-chloro-l-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((lS)-l-benzyl- 3-chloro-l-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide (these compounds may be prepared from the methods described in WO2017/153380); l-(6,7-dimethylpyrazolo[l,5-a]pyridin-3-yl)-4,4,5- trifluoro-3,3-dimethyl-isoquinoline, l-(6,7-dimethylpyrazolo[l,5-a]pyridin-3-yl)-4,4,6-trifluoro-3,3- dimethyl-isoquinoline, 4,4-difluoro-3,3-dimethyl-l-(6-methylpyrazolo[l,5-a]pyridin-3-yl)isoquinoline, 4,4-difluoro-3,3-dimethyl-l-(7-methylpyrazolo[l,5-a]pyridin-3-yl)isoquinoline, l-(6-chloro-7-methyl- pyrazolo[l,5-a]pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline (these compounds may be prepared from the methods described in W02017/025510); l-(4,5-dimethylbenzimidazol-l-yl)-4,4,5- trifluoro-3,3-dimethyl-isoquinoline, l-(4,5-dimethylbenzimidazol-l-yl)-4,4-difluoro-3,3-dimethyl- isoquinoline, 6-chloro-4,4-difluoro-3,3-dimethyl-l-(4-methylbenzimidazol-l-yl)isoquinoline, 4,4- difluoro-l-(5-fluoro-4-methyl-benzimidazol-l-yl)-3,3-dimethyl-isoquinoline, 3-(4,4-difluoro-3,3- dimethyl-l-isoquinolyl)-7,8-dihydro-6H-cyclopenta[e]benzimidazole (these compounds may be prepared from the methods described in WO2016/156085); N-methoxy-N-[[4-[5-(trifluoromethyl)- l,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-
(trifluoromethyl)-l,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, N-ethyl-2-methyl-N-[[4-[5-
(trifluoromethyl)-l,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, l-methoxy-3-methyl-l-[[4-[5-
(trifluoromethyl)-l,2,4-oxadiazol-3-yl]phenyl]methyl]urea, l,3-dimethoxy-l-[[4-[5-(trifluoromethyl)- l,2,4-oxadiazol-3-yl]phenyl]methyl]urea, 3-ethyl-l-methoxy-l-[[4-[5-(trifluoromethyl)-l,2,4- oxadiazol-3-yl]phenyl]methyl]urea, N-[[4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3- yl]phenyl]methyl]propanamide, 4.4-dimethyl-2-[[4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3- yl]phenyl]methyl]isoxazolidin-3-one, 5.5-dimethyl-2-[[4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3- yl]phenyl]methyl]isoxazolidin-3-one, ethyl l-[[4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3- yl]phenyl]methyl]pyrazole-4-carboxylate, N,N-dimethyl-l-[[4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3- yl]phenyl]methyl]-l,2,4-triazol-3-amine (these compounds may be prepared from the methods described in WO 2017/055473, WO 2017/055469, WO 2017/093348 and WO 2017/118689); 2-[6-(4- chlorophenoxy)-2-(trifluoromethyl)-3-pyridyl]-l-(l,2,4-triazol-l-yl)propan-2-ol (this compound may be prepared from the methods described in WO 2017/029179); 2-[6-(4-bromophenoxy)-2- (trifluoromethyl)-3-pyridyl]-l-(l,2,4-triazol-l-yl)propan-2-ol (this compound may be prepared from the methods described in WO 2017/029179); 3-[2-(l-chlorocyclopropyl)-3-(2-fluorophenyl)-2- hydroxy-propyl]imidazole-4-carbonitrile (this compound may be prepared from the methods described in WO 2016/156290); 3-[2-(l-chlorocyclopropyl)-3-(3-chloro-2-fluoro-phenyl)-2-hydroxy- propyl]imidazole-4-carbonitrile (this compound may be prepared from the methods described in WO 2016/156290); (4-phenoxyphenyl)methyl 2-amino-6-methyl-pyridine-3-carboxylate (this compound may be prepared from the methods described in WO 2014/006945); 2,6-Dimethyl-lH,5H- [l,4]dithiino[2,3-c:5,6-c']dipyrrole-l,3,5,7(2H,6H)-tetrone (this compound may be prepared from the methods described in WO 2011/138281) N-methyl-4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3- yl]benzenecarbothioamide; N-methyl-4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3-yl]benzamide; (Z,2E)- 5-[l-(2,4-dichlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl-pent-3-enamide (this compound may be prepared from the methods described in WO 2018/153707); N'-(2-chloro-5- methyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine; N'-[2-chloro-4-(2-fluorophenoxy)-5- methyl-phenyl]-N-ethyl-N-methyl-formamidine (this compound may be prepared from the methods described in WO 2016/202742); 2-(difluoromethyl)-N-[(3S)-3-ethyl-l,l-dimethyl-indan-4-yl]pyridine- 3-carboxamide (this compound may be prepared from the methods described in WO 2014/095675); (5-methyl-2-pyridyl)-[4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3-yl]phenyl]methanone, (3- methylisoxazol-5-yl)-[4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3-yl]phenyl]methanone (these compounds may be prepared from the methods described in WO 2017/220485); 2-oxo-N-propyl-2-[4- [5-(trifluoromethyl)-l,2,4-oxadiazol-3-yl]phenyl]acetamide (this compound may be prepared from the methods described in WO 2018/065414); ethyl l-[[5-[5-(trifluoromethyl)-l,2,4-oxadiazol-3-yl]-2- thienyl]methyl]pyrazole-4-carboxylate (this compound may be prepared from the methods described in WO 2018/158365); 2,2-difluoro-N-methyl-2-[4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3- yl]phenyl]acetamide, N-[(E)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3- yl] benzamide, N-[(Z)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3-yl]benzamide, N- [N-methoxy-C-methyl-carbonimidoyl]-4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3-yl]benzamide (these compounds may be prepared from the methods described in WO 2018/202428).
In particular, the compositions as described herein have been found to demonstrate superior tankmix stability with one or more of the components listed in Table B below.
Table B
Figure imgf000015_0001
Figure imgf000016_0001
Unless otherwise stated are percentages are given as percentages by total weight and all embodiments and preferred features may be combined in any combination.
The invention is described by the following non-limiting Examples.
Examples
Compositions according to the invention (Compositions 1 and A), together with a broad range of comparative compositions, were prepared with the components as set out in Tables 1 and 3.
Methodology
The prepared compositions were tested for a wide range of properties as set out below, with the results presented in Tables 2 and 4.
Wet sieve residue
Cyprodinil is sensitive to temperature in combination with water and a high wet sieve residue can result due to high temperatures during production. The following test was therefore established to establish suitable parameters for commercial product with the limit for a good quality product being <0.2% of residue.
50 g of product was poured into 500 mL of water. After 1 minute of standing, it was stirred for 5 minutes and the resulting suspension is then poured over a 45 pm fine mesh sieve. The sieve was rinsed for up to 10 minutes with tap water. The residue on the sieve was collected, dried and weighed. The result is presented as a percentage against the initial 50 g. Suspensibility
2.5g of product was weighed into a 30 °C preheated cylinder with 250 mL of water. The cylinder is inverted 180° for 30 times to disperse the product. Afterwards the cylinder is put into a 30 °C water bath and left standing for 30 minutes. Once the time is up, the top 90% of the suspension are removed and the rest is transferred into a glass beaker to be dried and weighed. The dried residue was used to calculate the suspensibility of the product. A minimum of 80% is necessary for a good product with lower numbers indicating insufficient dispersing agent or too much insoluble solid material in the composition.
Storage
Samples are stored for two weeks at 54 °C. The tests above are then repeated to determine shelf life and stability. If the Wet Sieve and/or Suspensibility results are very bad the samples were not stored and given an 'NDA' rating.
Leaf Residue
The presence of leaf residue was confirmed or denied through visual inspection.
Table 1
Figure imgf000018_0001
Table 2 - Results
Figure imgf000019_0001
Table 3
Figure imgf000020_0001
Table 4 — Results
Figure imgf000021_0001
In the tables above, only the compositions according to the invention demonstrate the necessary combination of technical properties required for a next generation, microplastic-free formulation.
The invention is defined by the claims.

Claims

Claims
1. A composition comprising cyprodinil and a lactose-based filler.
2. A composition according to claim 1 comprising no or substantially no microplastics.
3. A composition according to claim 1 or 2 wherein the composition is in the form of water- dispersible granules (WG).
4. A composition according to any of the preceding claims, wherein the cyprodinil is present in an amount of from 30 to 60% by weight.
5. A composition according to the any the preceding claims that further comprises fludioxinil.
6. A composition according to claim 4, wherein the fludioxinil is present in an amount of from 20 to 30% by weight.
7. A composition according to any of the preceding claims wherein the lactose-based filler is present in an amount of 20 to 50% by weight.
8. A composition according to any of the preceding claims comprising one or more dispersants, preferably in an amount of from 0.001 to 10% by weight.
9. A composition according to claim 7, wherein the one or more dispersants are selected from naphthalenesulfonic acid condensed with formaldehyde and/or lignosulphonate.
10. A composition according to any of the preceding claims where the composition contains no, or substantially no, sodium sulphate, silicium oxide, calcium carbonate, starch, silica and/or polyurea-based polymers.
11. A composition according to any of the preceding claims, wherein the composition demonstrates less than 0.2% residue when tested by the Wet Sieve Methodology.
12. A method of preparing a composition as defined in any of claims 1 to 10, preferably through extrusion.
13. A method of controlling or preventing phytopathogenic diseases, especially phytopathogenic fungi, on useful plants or on propagation material thereof, which comprises applying to the useful plants, the locus thereof or propagation material thereof a composition as defined in any one of claims 1 to 10.
14. A method according to claim 12, wherein fungi is selected from one or more of Botrytis, Monilinia, Nectria, Penicillium, Colletotrichum, Fusarium, Gloeosporium, Alternaria, Venturia, Sclerotinia, Stemphylium, Mycosphaerella, and Ascochyta.
PCT/EP2024/052980 2023-02-14 2024-02-07 Composition comprising cyprodinil and lactose-based filler WO2024170365A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GR20230100116 2023-02-14
GR20230100116 2023-02-14
GBGB2302668.5A GB202302668D0 (en) 2023-02-24 2023-02-24 Composition
GB2302668.5 2023-02-24

Publications (1)

Publication Number Publication Date
WO2024170365A1 true WO2024170365A1 (en) 2024-08-22

Family

ID=89905817

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/052980 WO2024170365A1 (en) 2023-02-14 2024-02-07 Composition comprising cyprodinil and lactose-based filler

Country Status (1)

Country Link
WO (1) WO2024170365A1 (en)

Citations (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011138281A2 (en) 2010-05-06 2011-11-10 Bayer Cropscience Ag Process for the preparation of dithiine tetracarboxydiimides
WO2012162472A1 (en) * 2011-05-26 2012-11-29 Syngenta Participations Ag Stabilized biocontrol water dispersible granules
WO2013087417A1 (en) * 2011-12-15 2013-06-20 Basf Se Solid agroformulations prepared from a melt of pesticide and polyalkoxylate, optionally containing liquid adjuvant complexed with polycarboxylate
WO2014006945A1 (en) 2012-07-04 2014-01-09 アグロカネショウ株式会社 2-aminonicotinic acid ester derivative and bactericide containing same as active ingredient
WO2014095675A1 (en) 2012-12-19 2014-06-26 Bayer Cropscience Ag Difluoromethyl-nicotinic-indanyl carboxamides as fungicides
WO2015155075A1 (en) 2014-04-11 2015-10-15 Syngenta Participations Ag Fungicidal n'-[2-methyl-6-[2-alkoxy-ethoxy]-3-pyridyl]-n-alkyl-formamidine derivatives for use in agriculture
US20160007592A1 (en) * 2013-02-28 2016-01-14 Sumitomo Chemical Company, Limited Water dispersible granules
WO2016156290A1 (en) 2015-04-02 2016-10-06 Bayer Cropscience Aktiengesellschaft Novel 5-substituted imidazole derivatives
WO2016156085A1 (en) 2015-03-27 2016-10-06 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2016202742A1 (en) 2015-06-15 2016-12-22 Bayer Cropscience Aktiengesellschaft Halogen-substituted phenoxyphenylamidines and the use thereof as fungicides
WO2017025510A1 (en) 2015-08-12 2017-02-16 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2017029179A1 (en) 2015-08-14 2017-02-23 Bayer Cropscience Aktiengesellschaft Triazole derivatives, intermediates thereof and their use as fungicides
WO2017055469A1 (en) 2015-10-02 2017-04-06 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2017055473A1 (en) 2015-10-02 2017-04-06 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2017093348A1 (en) 2015-12-02 2017-06-08 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2017118689A1 (en) 2016-01-08 2017-07-13 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2017153380A1 (en) 2016-03-10 2017-09-14 Syngenta Participations Ag Microbiocidal quinoline (thio)carboxamide derivatives
WO2017220485A1 (en) 2016-06-21 2017-12-28 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2018065414A1 (en) 2016-10-06 2018-04-12 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2018153707A1 (en) 2017-02-22 2018-08-30 Basf Se Crystalline forms of a strobilurin type compound for combating phytopathogenic fungi
WO2018158365A1 (en) 2017-03-03 2018-09-07 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2018202428A1 (en) 2017-05-02 2018-11-08 Basf Se Fungicidal mixture comprising substituted 3-phenyl-5-(trifluoromethyl)-1,2,4-oxadiazoles
WO2018228896A1 (en) 2017-06-14 2018-12-20 Syngenta Participations Ag Fungicidal compositions
WO2019110427A1 (en) 2017-12-04 2019-06-13 Syngenta Participations Ag Microbiocidal phenylamidine derivatives
WO2020056090A1 (en) 2018-09-14 2020-03-19 Fmc Corporation Fungicidal halomethyl ketones and hydrates
WO2020097012A1 (en) 2018-11-06 2020-05-14 Fmc Corporation Substituted tolyl as fungicides
WO2023222723A1 (en) * 2022-05-20 2023-11-23 Syngenta Crop Protection Ag Pesticidal compositions

Patent Citations (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011138281A2 (en) 2010-05-06 2011-11-10 Bayer Cropscience Ag Process for the preparation of dithiine tetracarboxydiimides
WO2012162472A1 (en) * 2011-05-26 2012-11-29 Syngenta Participations Ag Stabilized biocontrol water dispersible granules
WO2013087417A1 (en) * 2011-12-15 2013-06-20 Basf Se Solid agroformulations prepared from a melt of pesticide and polyalkoxylate, optionally containing liquid adjuvant complexed with polycarboxylate
WO2014006945A1 (en) 2012-07-04 2014-01-09 アグロカネショウ株式会社 2-aminonicotinic acid ester derivative and bactericide containing same as active ingredient
WO2014095675A1 (en) 2012-12-19 2014-06-26 Bayer Cropscience Ag Difluoromethyl-nicotinic-indanyl carboxamides as fungicides
US20160007592A1 (en) * 2013-02-28 2016-01-14 Sumitomo Chemical Company, Limited Water dispersible granules
WO2015155075A1 (en) 2014-04-11 2015-10-15 Syngenta Participations Ag Fungicidal n'-[2-methyl-6-[2-alkoxy-ethoxy]-3-pyridyl]-n-alkyl-formamidine derivatives for use in agriculture
WO2016156085A1 (en) 2015-03-27 2016-10-06 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2016156290A1 (en) 2015-04-02 2016-10-06 Bayer Cropscience Aktiengesellschaft Novel 5-substituted imidazole derivatives
WO2016202742A1 (en) 2015-06-15 2016-12-22 Bayer Cropscience Aktiengesellschaft Halogen-substituted phenoxyphenylamidines and the use thereof as fungicides
WO2017025510A1 (en) 2015-08-12 2017-02-16 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2017029179A1 (en) 2015-08-14 2017-02-23 Bayer Cropscience Aktiengesellschaft Triazole derivatives, intermediates thereof and their use as fungicides
WO2017055469A1 (en) 2015-10-02 2017-04-06 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2017055473A1 (en) 2015-10-02 2017-04-06 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2017093348A1 (en) 2015-12-02 2017-06-08 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2017118689A1 (en) 2016-01-08 2017-07-13 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2017153380A1 (en) 2016-03-10 2017-09-14 Syngenta Participations Ag Microbiocidal quinoline (thio)carboxamide derivatives
WO2017220485A1 (en) 2016-06-21 2017-12-28 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2018065414A1 (en) 2016-10-06 2018-04-12 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2018153707A1 (en) 2017-02-22 2018-08-30 Basf Se Crystalline forms of a strobilurin type compound for combating phytopathogenic fungi
WO2018158365A1 (en) 2017-03-03 2018-09-07 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2018202428A1 (en) 2017-05-02 2018-11-08 Basf Se Fungicidal mixture comprising substituted 3-phenyl-5-(trifluoromethyl)-1,2,4-oxadiazoles
WO2018228896A1 (en) 2017-06-14 2018-12-20 Syngenta Participations Ag Fungicidal compositions
WO2019110427A1 (en) 2017-12-04 2019-06-13 Syngenta Participations Ag Microbiocidal phenylamidine derivatives
WO2020056090A1 (en) 2018-09-14 2020-03-19 Fmc Corporation Fungicidal halomethyl ketones and hydrates
WO2020097012A1 (en) 2018-11-06 2020-05-14 Fmc Corporation Substituted tolyl as fungicides
WO2023222723A1 (en) * 2022-05-20 2023-11-23 Syngenta Crop Protection Ag Pesticidal compositions

Similar Documents

Publication Publication Date Title
WO2021043616A1 (en) Strigolactone derivatives as plant growth regulator compounds
EP4280879A1 (en) Method for the control or suppression of phytopathogenic bacteria
IL312109A (en) Fungicidal compositions comprising fludioxonil
WO2023072785A1 (en) Fungicidal compositions
WO2024170365A1 (en) Composition comprising cyprodinil and lactose-based filler
WO2020127319A1 (en) Plant growth regulator compositions
WO2024038053A1 (en) New use of pydiflumetofen
US20230320361A1 (en) Formulations
AU2022413447A1 (en) Fungicidal compositions
WO2023117625A1 (en) Fungicidal compositions
WO2022084346A1 (en) Zealactone derivatives as plant growth regulators
WO2023209238A1 (en) Fungicidal compositions
WO2022048988A1 (en) Plant growth regulator compounds
WO2021180596A1 (en) Methods of controlling or preventing infestation of plants by the phytopathogenic microorganism corynespora cassiicola
WO2023118434A1 (en) Pesticidally active amide compounds
WO2021180598A1 (en) Methods of controlling or preventing infestation of plants by the phytopathogenic microorganism corynespora cassiicola
EP4333618A1 (en) Use of clethodim for insect control
WO2021180592A1 (en) Methods of controlling or preventing infestation of plants by the phytopathogenic microorganism corynespora cassiicola

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24704705

Country of ref document: EP

Kind code of ref document: A1