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WO2024165642A1 - Cosmetic or dermatological preparation containing cordyceps extract, and method for producing such a preparation - Google Patents

Cosmetic or dermatological preparation containing cordyceps extract, and method for producing such a preparation Download PDF

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Publication number
WO2024165642A1
WO2024165642A1 PCT/EP2024/053097 EP2024053097W WO2024165642A1 WO 2024165642 A1 WO2024165642 A1 WO 2024165642A1 EP 2024053097 W EP2024053097 W EP 2024053097W WO 2024165642 A1 WO2024165642 A1 WO 2024165642A1
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Prior art keywords
oil
cosmetic
preparation
extract
cordyceps
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PCT/EP2024/053097
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German (de)
French (fr)
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Goethe Biotechnology Gmbh
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Publication of WO2024165642A1 publication Critical patent/WO2024165642A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the invention relates to a cosmetic or dermatological preparation. It further relates to a process for producing such a preparation.
  • Cordyceps extract containing the active ingredient cordycepin
  • this active ingredient is said to be highly effective against various types of cancer or tumor diseases, and to strengthen the lungs and liver, both in terms of their development and their spread. It can be obtained from the medicinal mushroom Cordyceps.
  • This is one of the most powerful medicinal mushrooms in traditional Chinese medicine.
  • Athletes use Cordyceps to increase their stamina and performance. People with weak immune systems use Cordyceps to strengthen their immune system, and those with autoimmune diseases can suppress it with the help of the regulating medicinal mushroom.
  • Cordycepin or 3'-deoxyadenosine is a derivative of the nucleoside adenosine, which differs from it by replacing the hydroxy group in the 3' position with a hydrogen. It was originally obtained from the Cordyceps mushroom, and is therefore usually a component of Cordyceps extract, but can now also be produced synthetically. It has the chemical formula C10H13N5O3 and a molecular weight of 251.24 mol/g and the structure:
  • the invention is therefore based on the object of specifying a dosage form which is particularly suitable for these purposes.
  • a cosmetic or dermatological preparation comprising as main components extract of the Cordyceps mushroom and an oil.
  • at least one of argan oil, jojoba oil and/or MCT oil is provided.
  • the invention is based on the idea that, in view of the above-mentioned design objectives, Cordyceps extract should be administered in a particularly efficient manner so that the active ingredient can be delivered to the human organism in a particularly precise manner. This makes it possible to use this scarce resource particularly economically while making full use of its therapeutic potential.
  • the invention provides for the Cordyceps extract to be administered in the form of a cosmetic or dermatological preparation. Such a composition is intended in particular for application to the skin. By means of such a presentation, the active ingredient can be absorbed into the body through the skin and develop its effect there; on the other hand, it can also be made available directly for the treatment of dermatological problems or indications.
  • this active ingredient should be suitably incorporated into additives or carriers that particularly promote absorption through the skin.
  • additives or carriers that particularly promote absorption through the skin.
  • it is intended to be incorporated into oil, which particularly promotes absorption through the skin.
  • the oils argan oil, jojoba oil and/or MCT oil are particularly advantageous for this.
  • MCT oil in particular which is considered a source of medium-chain fatty acids (“medium chain triglycerides”), is considered to be beneficial for application to the skin and to be good for the skin.
  • the oils mentioned are particularly good for the delivery of active ingredients, especially when combined with one another. According to a preferred aspect of the invention, they are therefore provided together as components. According to one aspect of the invention, it is precisely the mixture of these oils that ensures good absorption of the active ingredients through the skin.
  • the volume proportion of jojoba oil is at least three times as large as the volume proportion of argan oil; according to an alternative or additional aspect of the invention, the volume proportion of MCT oil is also at least four times as large as the volume proportion of argan oil.
  • the composition is prepared from the following quantities:
  • the dosage ratios are as follows:
  • ultrasound extraction is used to extract the active ingredients of the Cordyceps mushroom extract into the oil when producing the composition. After extraction, filtering should not take place, as this could weaken the effectiveness. Instead, according to one aspect of the invention, the extracted oil is freed of solids exclusively by sedimentation (centrifugation).
  • a good distribution of the mushroom extract in the oil is ensured, for example by means of a stirrer, in order to be able to break it down better.
  • the cosmetic or dermatological composition can be provided in different processing forms, such as for transdermal administration as a cream or lotion.
  • the cosmetic or dermatological composition comprising one or more of the oils mentioned is provided with the extract of the Cordyceps mushroom as active ingredient, compared to the addition of just cordycepin.
  • the extract of the Cordyceps mushroom as active ingredient, compared to the addition of just cordycepin.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Birds (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to a cosmetic or dermatological preparation comprising as the main ingredient Cordyceps extract and at least one from the group consisting of argan oil, jojoba oil and/or MCT oil.

Description

Beschreibung Description
KOSMETISCHE ODER DERMATOLOGISCHE ZUBEREITUNG ENTHALTEND CORDYCEPSPILZ-EXTRAKT UND VERFAHREN ZUR HERSTELLUNG EINER SOLCHEN ZUBEREITUNG COSMETIC OR DERMATOLOGICAL PREPARATION CONTAINING CORDYCEPS MUSHROOM EXTRACT AND METHOD FOR PRODUCING SUCH A PREPARATION
Die Erfindung betrifft eine kosmetische oder dermatologische Zubereitung. Sie bezieht sich weiter auf ein Verfahren zur Herstellung einer solchen Zubereitung. The invention relates to a cosmetic or dermatological preparation. It further relates to a process for producing such a preparation.
Cordyceps-Extrakt, enthaltend den Wirkstoff Cordycepin, findet im Rahmen der traditionellen chinesischen Medizin bereits seit geraumer Zeit Verwendung zu verschiedenartigen Behandlungszwecken. Insbesondere wird diesem Wirkstoff eine hohe Wirksamkeit gegen verschiedenartige Krebs- oder Tumorerkrankungen, Lunge-, und Leberstärkung zugeschrieben, sowohl was deren Entstehung als auch deren Ausbreitung betrifft. Er kann gewonnen werden aus dem Heilpilz Cordyceps. Dieser ist einer der stärksten Heilpilze der Traditionellen Chinesischen Medizin. Sportler erhöhen mit Cordyceps ihre Kondition und Leistungsfähigkeit. Menschen mit Abwehrschwäche stärken mit Cordyceps ihr Immunsystem, und jene mit Autoimmunerkrankungen drosseln es mit Hilfe des regulierenden Heilpilzes. Cordyceps extract, containing the active ingredient cordycepin, has been used for a long time in traditional Chinese medicine for various treatment purposes. In particular, this active ingredient is said to be highly effective against various types of cancer or tumor diseases, and to strengthen the lungs and liver, both in terms of their development and their spread. It can be obtained from the medicinal mushroom Cordyceps. This is one of the most powerful medicinal mushrooms in traditional Chinese medicine. Athletes use Cordyceps to increase their stamina and performance. People with weak immune systems use Cordyceps to strengthen their immune system, and those with autoimmune diseases can suppress it with the help of the regulating medicinal mushroom.
Cordycepin oder 3'-Desoxyadenosin ist ein Derivat des Nukleosids Adenosin, das sich von diesem durch den Ersatz der Hydroxygruppe in 3'-Position durch einen Wasserstoff unterscheidet. Es wurde ursprünglich aus dem Pilz Cordyceps gewonnen, ist somit üblicherweise Bestandteil von Cordyceps-Extrakt, kann aber heute auch synthetisch hergestellt werden. Es hat die chemische Formel C10H13N5O3 und eine Molmasse von 251 ,24 mol/g und die Struktur: Cordycepin or 3'-deoxyadenosine is a derivative of the nucleoside adenosine, which differs from it by replacing the hydroxy group in the 3' position with a hydrogen. It was originally obtained from the Cordyceps mushroom, and is therefore usually a component of Cordyceps extract, but can now also be produced synthetically. It has the chemical formula C10H13N5O3 and a molecular weight of 251.24 mol/g and the structure:
Figure imgf000003_0001
Figure imgf000003_0001
Aufgrund seiner anerkannt guten Wirkungsweise besteht das Bedürfnis, diesen Wirkstoff für den einfachen und alltäglichen Gebrauch verfügbar und einfach nutzbar zu machen. Insbesondere sollte dabei eine Verfügbarkeit in vergleichsweise großen Mengen ermöglicht werden, was angesichts der Knappheit und des hohen Preises dieses Produkts nur bedingt möglich erscheint. Due to its recognized effectiveness, there is a need to make this active ingredient available and easy to use for simple, everyday use. In particular, it should be available in relatively large quantities, which seems only possible to a limited extent given the scarcity and high price of this product.
Der Erfindung liegt daher die Aufgabe zugrunde, eine für diese Zwecke besonders geeignete Darreichungsform anzugeben. The invention is therefore based on the object of specifying a dosage form which is particularly suitable for these purposes.
Diese Aufgabe wird erfindungsgemäß gelöst durch eine kosmetische oder dermatologische Zubereitung, umfassend als Hauptbestandteile Extrakt des Cordyceps- pilzes sowie einem Öl. Gemäß einem Aspekt der Erfindung ist mindestens eins von Arganöl, Jojobaöl und/oder MCT-ÖI vorgesehen. This object is achieved according to the invention by a cosmetic or dermatological preparation comprising as main components extract of the Cordyceps mushroom and an oil. According to one aspect of the invention, at least one of argan oil, jojoba oil and/or MCT oil is provided.
Die Erfindung geht dabei von der Überlegung aus, dass im Hinblick auf die oben genannten Auslegungsziele eine Darreichung von Cordyceps-Extrakt auf besonders effiiziente Weise erfolgen sollte, so dass der Wirkstoff dem menschlichen Organismus besonders zielgenau zugeführt werden kann. Damit ist ein besonders sparsamer Umgang mit dieser knappen Ressource bei hoher Ausnutzung des therapeutischen Potentials möglich. Um dies zu ermöglichen, ist erfindungsgemäß vorgesehen, den Cordyceps-Extrakt in der Form einer kosmetischen oder derma- tologischen Zusammensetzung bereitzustellen. Eine solche Zusammensetzung ist insbesondere zur Auftragung auf die Haut vorgesehen. Durch eine solche Darreichung kann einerseits der Wirkstoff über die Haut in den Körper aufgenommen werden und dort seine Wirkung entfalten; andererseits kann er aber auch direkt für die Behandlung dermatologischer Probleme oder Indikationen bereitgestellt werden. The invention is based on the idea that, in view of the above-mentioned design objectives, Cordyceps extract should be administered in a particularly efficient manner so that the active ingredient can be delivered to the human organism in a particularly precise manner. This makes it possible to use this scarce resource particularly economically while making full use of its therapeutic potential. In order to make this possible, the invention provides for the Cordyceps extract to be administered in the form of a cosmetic or dermatological preparation. Such a composition is intended in particular for application to the skin. By means of such a presentation, the active ingredient can be absorbed into the body through the skin and develop its effect there; on the other hand, it can also be made available directly for the treatment of dermatological problems or indications.
Um eine solche, gemäß einem Aspekt der Erfindung vorgesehene Zusammensetzung zur äußerlichen Anwendung, also zur Verabreichung von Cordyceps-Extrakt auf der Haut, bereitstellen zu können, sollte dieser Wirkstoff geeeignet in Zusatzoder Trägerstoffe eingebunden werden, die die Aufnahme über die Haut besonders begünstigen. Hierzu ist gemäß einem Aspekt der Erfindung die Einbindung in Öl vorgesehen, die die Aufnahme über die Haut besondere begünstigt. Wie sich dabei völlig überraschend herausgestellt hat, sind hierfür die Öle Arganöl, Jojobaöl und/oder MCT-ÖI besonders vorteilhaft. In order to be able to provide such a composition for external use, i.e. for administering Cordyceps extract to the skin, as provided in one aspect of the invention, this active ingredient should be suitably incorporated into additives or carriers that particularly promote absorption through the skin. For this purpose, in one aspect of the invention, it is intended to be incorporated into oil, which particularly promotes absorption through the skin. As has been found, quite surprisingly, the oils argan oil, jojoba oil and/or MCT oil are particularly advantageous for this.
Gerade MCT-ÖI, das als Quelle für mittelkettige Fettsäuren anzusehen ist („Medium Chain Triglycerides“), wird ohnehin als günstig für die Anwendung auf der Haut und als hautpflegend angesehen. MCT oil in particular, which is considered a source of medium-chain fatty acids (“medium chain triglycerides”), is considered to be beneficial for application to the skin and to be good for the skin.
Wie sich weiter völlig überraschend herausgestellt hat, sind die genannten Öle gerade in Kombination miteinander besonders günstig für die Wirkstoffzuführung. Gemäß einem bevorzugten Aspekt der Erfindung sind sie daher als Bestandteile gemeinsam vorgesehen. Gerade die Mischung dieser Öle sorgt gemäß einem Aspekt der Erfindung für eine gute Aufnahme der Wirkstoffe über die Haut. Gemäß einem Aspekt der Erfindung ist der Volumenanteil von Jojobaöl mindestens dreimal so groß wie der Volumenanteil von Arganöl; gemäß einem alternativen oder zusätzlichen Aspekt der Erfindung ist zudem der Volumenanteil von MCT-ÖI mindestens viermal so groß ist wie der Volumenanteil von Arganöl. In einem besonders bevorzugten Beispiel wird die Zusammensetzung hergestellt aus folgenden Mengenbeigaben: As has also been discovered, completely surprisingly, the oils mentioned are particularly good for the delivery of active ingredients, especially when combined with one another. According to a preferred aspect of the invention, they are therefore provided together as components. According to one aspect of the invention, it is precisely the mixture of these oils that ensures good absorption of the active ingredients through the skin. According to one aspect of the invention, the volume proportion of jojoba oil is at least three times as large as the volume proportion of argan oil; according to an alternative or additional aspect of the invention, the volume proportion of MCT oil is also at least four times as large as the volume proportion of argan oil. In a particularly preferred example, the composition is prepared from the following quantities:
300ml Arganöl 300ml argan oil
1000ml Jojobaöl 1000ml jojoba oil
1200ml MCT-ÖI 1200ml MCT oil
100g Cordyceps Extrakt 1 % 100g Cordyceps extract 1%
10g Cordyceps Extrakt 98% 10g Cordyceps extract 98%
Abgebildet auf den Wirkstoffanteil des Cordycepins an sich ergeben sich damit die Dosierungsverhältnisse: Based on the active ingredient content of cordycepin itself, the dosage ratios are as follows:
2500ml = 10,5g reines Cordycepin = 10500 mg 2500ml = 10.5g pure cordycepin = 10500 mg
10500mg / 2500ml = Pro ml Öl 4,2mg reines Cordycepin als Wirkstoff 10500mg / 2500ml = 4.2mg pure cordycepin as active ingredient per ml of oil
Bei der Herstellung der Zusammensetzung ist gemäß einem als eigenständig erfinderisch angesehenen Aspekt die Ultraschall-Extraktion vorgesehen, um die Wirkstoffe des Cordycepspilz-Extraktes in das Öl zu extrahieren. Nach der Extraktion sollte nicht filtriert werden, da damit eine Abschwächung der Wirkkräfte einhergehen könnte. Stattdessen ist gemäß einem Aspekt der Erfindung vorgesehen, das extrahierte Öl ausschließlich durch Sedimentation (Zentrifugation) von enthaltenen Feststoffen zu befreien. According to an aspect considered to be independently inventive, ultrasound extraction is used to extract the active ingredients of the Cordyceps mushroom extract into the oil when producing the composition. After extraction, filtering should not take place, as this could weaken the effectiveness. Instead, according to one aspect of the invention, the extracted oil is freed of solids exclusively by sedimentation (centrifugation).
Während der Extraktion wird gemäß einem Aspekt der Erfindung, beispielsweise mittels eines Rührwerks, für eine gute Verteilung des Pilzextraktes im Öl gesorgt, um ihn besser aufschliessen zu können. During extraction, according to one aspect of the invention, a good distribution of the mushroom extract in the oil is ensured, for example by means of a stirrer, in order to be able to break it down better.
Die kosmetische oder dermatologische Zusammensetzung kann in unterschiedlichen Verarbeitungsformen bereitgestellt werden, wie z.B. zur transdermalen Verabreichung als Creme oder Lotion. The cosmetic or dermatological composition can be provided in different processing forms, such as for transdermal administration as a cream or lotion.
Gemäß einem als eigenständig erfinderisch angesehenen Aspekt ist die kosmetische oder dermatologische Zusammensetzung, umfassend eines oder mehrere der genannten Öle, mit dem Extrakt des Cordycepspilzes als Wirkstoff versehen, gegenüber der Zugabe lediglich von Cordycepin. Wie sich überraschend herausgestellt hat, ist ein solcher Vollspektrum-Auszug des Cordyceps-Pilzes besonders günstig in seiner Wirkung. According to an aspect considered to be independently inventive, the cosmetic or dermatological composition comprising one or more of the oils mentioned is provided with the extract of the Cordyceps mushroom as active ingredient, compared to the addition of just cordycepin. Surprisingly, it has been found that such a full-spectrum extract of the cordyceps mushroom is particularly beneficial in its effects.

Claims

Ansprüche Claims
1. Kosmetische oder dermatologische Zubereitung, umfassend als Hauptbestandteile Extrakt des Cordycepspilzes sowie mindestens eins von Arganöl, Jojobaöl und/oder MCT-ÖI. 1. Cosmetic or dermatological preparation comprising as main ingredients extract of Cordyceps mushroom and at least one of argan oil, jojoba oil and/or MCT oil.
2. Zubereitung nach Anspruch 1 , bei der als Bestandteile Arganöl, Jojobaöl und MCT-ÖI vorgesehen sind. 2. Preparation according to claim 1, in which the ingredients are argan oil, jojoba oil and MCT oil.
3. Zubereitung nach Anspruch 1 oder 2, bei der der Volumenanteil von Jojobaöl mindestens drei mal so groß ist wie der Volumenanteil von Arganöl. 3. Preparation according to claim 1 or 2, wherein the volume fraction of jojoba oil is at least three times as large as the volume fraction of argan oil.
4. Zubereitung nach einem der Ansprüche 1 bis 3, bei der der Volumenanteil von MCT-ÖI mindestens viermal so groß ist wie der Volumenanteil von Arganöl. 4. Preparation according to one of claims 1 to 3, in which the volume fraction of MCT oil is at least four times as large as the volume fraction of argan oil.
5. Verfahren zur Herstellung einer kosmetischen oder dermatologischen Zubereitung nach einem der Ansprüche 1 bis 4, bei dem Cordyceps-Extrakt durch Ultraschall-Extraktion in das Öl extrahiert und das Öl anschließend durch Zentrifugation von Feststoffen befreit wird. 5. A process for producing a cosmetic or dermatological preparation according to one of claims 1 to 4, in which Cordyceps extract is extracted into the oil by ultrasonic extraction and the oil is then freed from solids by centrifugation.
PCT/EP2024/053097 2023-02-08 2024-02-07 Cosmetic or dermatological preparation containing cordyceps extract, and method for producing such a preparation WO2024165642A1 (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107099378A (en) * 2016-02-20 2017-08-29 王弘 A kind of Cordyceps militaris aromatic oil and preparation method thereof
CN110075015A (en) * 2019-05-27 2019-08-02 徐子轩 Aweto and its application and skin care item in skin care item
WO2023043853A1 (en) * 2021-09-14 2023-03-23 Nulixir Inc. Oral compositions with improved bioavailability and methods of making the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107099378A (en) * 2016-02-20 2017-08-29 王弘 A kind of Cordyceps militaris aromatic oil and preparation method thereof
CN110075015A (en) * 2019-05-27 2019-08-02 徐子轩 Aweto and its application and skin care item in skin care item
WO2023043853A1 (en) * 2021-09-14 2023-03-23 Nulixir Inc. Oral compositions with improved bioavailability and methods of making the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE GNPD [online] MINTEL; 19 September 2017 (2017-09-19), ANONYMOUS: "Woman's Power Serum", XP093026771, retrieved from https://www.gnpd.com/sinatra/recordpage/5111001/ Database accession no. 5111001 *
DATABASE GNPD [online] MINTEL; 26 September 2022 (2022-09-26), ANONYMOUS: "Palace Cordyceps Sinensis Cleansing Balm", XP093161435, retrieved from https://www.gnpd.com/sinatra/recordpage/9925750/ Database accession no. 9925750 *

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