WO2023233377A1

WO2023233377A1 - Composition comprising copper-based fungicide

Info

Publication number: WO2023233377A1
Application number: PCT/IB2023/055703
Authority: WO
Inventors: Arunagirinathan Manickam ADHIMOOLAM; Krishna Vasu JUTHIGA VV
Original assignee: Adama Makhteshim Ltd.
Priority date: 2022-06-02
Filing date: 2023-06-02
Publication date: 2023-12-07
Also published as: AR129516A1; TW202410807A

Abstract

The present invention provides a composition comprising (1) a copper-based fungicide, (2) water and (3) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants, and any combination thereof, wherein the copper-based fungicide is suspended in the water. The present invention also provides processes for preparing the herein described compositions and methods of their use.

Description

COMPOSITION COMPRISING COPPER-BASED FUNGICIDE

Throughout this application various publications are referenced. The disclosures of these documents in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this invention pertains.

TECHNICAL FIELD

The present invention provides a composition comprising (1) a copper-based fungicide, (2) at least one fungicide (I) selected from the group consisting of strobilurin fungicides, azole fungicides, benzamide fungicides, morpholines, Qil fungicides, SDHI and any combination thereof, (3) water, and (4) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein the copper-based fungicide is suspended in the water. The present invention also provides processes for preparing the herein described compositions and methods of their use.

BACKGROUND

Copper-based fungicides are well-known fungicides which are also combined with other/different fungicides.

One type of formulation which can be used for combining at least two types of fungicides is a suspoemulsion, where the copper-based fungicide is suspended in water and at least one additional fungicide is dissolved in a water immiscible carrier which is dispersed as oil drops in the continuous water phase.

Formulating suspoemulsions of copper-based fungicide(s) is challenging. There is a need to develop stable suspoemulsions. SUMMARY OF THE INVENTION

The present invention provides a composition comprising (1) a copper-based fungicide, (2) water and (3) at least one surfactant selected from the group consisting of taurate- based surfactants, isethionate-based surfactants and any combination thereof, wherein the copper-based fungicide is suspended in the water.

The present invention provides a composition comprising (1) a copper-based fungicide, (2) water, (3) a water immiscible carrier and (4) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein the copper-based fungicide is suspended in the water.

The present invention provides a composition comprising (1) a copper-based fungicide, (2) at least one fungicide (I) selected from the group consisting of strobilurin fungicides, azole fungicides, benzamide fungicides, morpholines, Qil fungicides, SDHI and any combination thereof, (3) water, and (4) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein the copper-based fungicide is suspended in the water.

The present invention provides a composition comprising (1) a copper-based fungicide, (2) at least one fungicide (I) selected from the group consisting of strobilurin fungicides, azole fungicides, benzamide fungicides, morpholines, Qil fungicides, SDHI and any combination thereof, (3) water, (4) a water immiscible carrier, and (5) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate- based surfactants and any combination thereof, wherein the copper-based fungicide is suspended in the water and at least one fungicide (I) is dissolved in the water immiscible carrier.

The present invention provides a composition comprising (1) a copper-based fungicide selected from the group consisting of Bordeaux mixture, copper oxychloride, copper oxide, copper sulphate and any combination thereof, (2) at least one fungicide (I) selected from the group consisting of strobilurin fungicides, azole fungicides, benzamide fungicides, morpholines, Qil fungicides, SDHI and any combination thereof, (3) water, (4) a water immiscible carrier, and (5) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein the copper-based fungicide is suspended in the water and at least one fungicide (I) is dissolved in the water immiscible carrier.

The present invention provides a composition comprising (1) a copper-based fungicide selected from the group consisting of Bordeaux mixture, copper oxychloride, copper oxide, copper sulphate and any combination thereof, (2) at least one fungicide (I) selected from the group consisting of strobilurin fungicides, azole fungicides, benzamide fungicides, morpholines, Qil fungicides, SDHI and any combination thereof, (3) water, (4) a water immiscible carrier, and (5) a taurate-based surfactant, wherein the copper-based fungicide is suspended in the water and at least one fungicide (I) is dissolved in the water immiscible carrier.

The present invention also provides a diluted composition prepared from the composition described herein.

The present invention provides a process for preparing the composition described herein, wherein the process comprises the following steps: (a) preparing an aqueous composition (composition 1) of the copper-based fungicide and optional additional fungicide, (b) preparing an emulsifiable concentrate comprising the fungicide (I) (composition 2), and (c) mixing composition 1 from step (a) and composition 2 from step (b) in the presence of at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof.

The present invention also provides a method for controlling fungal disease comprising applying an effective amount of any one of the herein described compositions to a plant, a locus thereof, propagation material thereof, or an area infested with the unwanted insects so as to thereby control the pathogen disease.

DETAILED DESCRIPTION

Unless defined otherwise, all technical and scientific terms used herein have the meaning commonly understood by persons of ordinary skill in the art to which this subject matter pertains.

The term “a” or “an”, as used herein, includes the singular and the plural, unless specifically stated otherwise. Therefore, the terms “a,” “an,” or “at least one” can be used interchangeably in this application.

As used herein, the term “about” when used in connection with a numerical value includes ±10% from the indicated value. In addition, all ranges directed to the same component or property herein are inclusive of the endpoints, are independently combinable, and include all intermediate points and ranges. It is understood that where a parameter range is provided, all integers within that range, and tenths thereof, are also provided by the invention. For example, “30-45%” includes 30%, 30.1%, 30.2%, etc. up to 45%.

The term “crop”, as is used herein, includes but is not limited to cereals such as wheat, barley, rye, oats, sorghum and millet, rice, cassava and maize, and crops that produce, for example, peanut, sugar beet, cotton, soya, oilseed rape, potato, tomato, peach and vegetables.

The term “part of a plant”, as is used herein, indicates a part of a plant including, but not limited to, pollen, ovule, leaf, root, flower, fruit, stem, bulb, com, branch and seed.

The term "suspoemulsion", as used herein, refers to a suspension of solid particles in a water and dispersion of oil drops intended for dilution with water prior to use. The abbreviation SE may also be used to designate a suspoemulsion.

The term "suspension concentrate", as used herein, refers to a suspension of solid particles in a liquid intended for dilution with water prior to use. In some embodiments, the suspension concentrate is an aqueous suspension concentrate. The abbreviation SC may also be used to designate a suspension concentrate. Compositions

Suspoemulsions comprising copper-based fungicides suffer from phase separation and/or increased viscosity. The present invention provides compositions comprising copper-based fungicides and taurate-based and/or isethionate-based surfactants with reduced viscosity and/or reduced phase separation.

In some embodiments, the composition comprising at least one additional fungicide (I). In some embodiments, the fungicide (I) is selected from the group consisting of strobilurin fungicides, azole fungicides, benzamide fungicides, morpholines, Qil fungicides, SDHI and any combination thereof.

In some embodiments, the composition further comprises a water immiscible carrier. In some embodiments, the water immiscible carrier comprises at least one fungicide

(1). In some embodiments, the copper-based fungicide is suspended in the water and at least one fungicide (I) is dissolved in the water immiscible carrier.

The present invention provides a composition comprising (1) a copper-based fungicide,

(2) water, (3) a water-immiscible carrier, and (4) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein the copper-based fungicide is suspended in the water.

In some embodiments, the copper-based fungicide selected from the group consisting of Bordeaux mixture, copper oxychloride, copper oxide, copper sulphate and any combination thereof. In some embodiments, the copper-based fungicide is the Bordeaux mixture. In some embodiments, the copper-based fungicide is copper oxychloride.

In some embodiments, the comprises one or more anionic surfactant selected from isethionate surfactants and/or taurate surfactants according to the structure:

wherein:

R¹ is alkyl, alkenyl, aryl, or aralkyl with 6 to 25 carbon atoms, preferably 12 to 18 carbon atoms,

R² is alkylene, which may optionally be substituted on one or more of such methylene units with alkyl, alkoxyl, alkenyl, aryl, aralkyl, alkaryl, or heterocyclyl, and which may optionally be interrupted at one or more positions by an oxygen atom,

X is O or NR³,

R³ is H or alkyl,

Y is SO³-

M⁺ is a cation.

In one embodiment, R² is C1-C2 alkyl.

In one embodiment, M⁺ is sodium, potassium, lithium, calcium, magnesium, ammonium cation, or an ammonium cation, such as, for example, an isopropylammonium, monoethanolammonium, diethanolammonium, or triethanolammonium cation. More typically, M⁺ is a sodium cation.

In some embodiments, at least one surfactant is selected from isethionate surfactants. Isethionate surfactants are esters of isethionic acid and salts thereof. In one embodiment, the surfactant comprises one or more isethionate surfactant according to the structure:

wherein:

R⁴ is alkyl, alkenyl, aryl, or aralkyl, R⁵ and R⁶ are each independently H or alkyl, and

M⁺ is a cation.

In one embodiment, R⁴ is a (C6-C25) alkyl and R⁵ and R⁶ are each independently H or (C1-C4) alkyl, more typically H or methyl.

In one embodiment, R⁴ is (C6-C25) alkyl and R⁵ and R⁶ are each independently H or (C1-C4) alkyl, more typically H or methyl, and M⁺ is a sodium, potassium, or ammonium cation.

In an embodiment, the isethionate surfactants are compounds in which R⁵ and R⁶ are hydrogen atoms and R⁴ has 12 to 18 carbon atoms.

Suitable isethionate surfactant compounds according to structure (3) include, for example, sodium lauroyl isethionate, sodium lauroyl isethionate, sodium myristoyl isethionate, sodium cocoyl isethionate, sodium oleoyl isethionate, and ammonium oleoyl isethionate.

In some embodiments, the composition comprises a taurate-based surfactant. In some embodiments, the surfactant is taurate-based surfactant.

In some embodiments of the present invention, the taurate-based surfactant is chosen from a salt of a fatty acid amide of taurine, a salt of a fatty acid amide of N-methyl taurine, and combinations thereof.

In an embodiment, the fatty acid chains of the taurate surfactants have 6 carbon atoms or more. In an embodiment, the taurate surfactant includes a fatty acid chain having 12 to 25 carbon atoms. The specified number of carbon atoms of the fatty acid chains described herein indicate the average chain length of the fatty acid chain, and lesser amounts of taurate surfactants having chain lengths that are shorter or longer that the lengths that are specified can be included, depending on the degree of purification used for making the particular ingredient, as would be understood by one of ordinary skill in the art. Blends of various lengths of fatty acids can be employed.

In some embodiments, the taurate surfactant has the following structure:

Wherein R¹ is a saturated or unsaturated, straight, or branched alkyl or alkenyl group with 6 to 25 carbon atoms, preferably 12 to 18 carbon atoms, R² is H, methyl, or ethyl, and M⁺ is a cation, preferably selected from sodium, potassium, calcium, magnesium, or ammonium. Suitable examples are potassium cocoyl taurate, potassium methyl cocoyl taurate, sodium caproyl methyl taurate, sodium cocoyl taurate, sodium lauroyl taurate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium methyl myristoyl taurate, sodium methyl oleoyl taurate, sodium methyl palmitoyl taurate, sodium methyl stearoyl taurate, sodium n-isostearoyl methyltaurate, calcium lauroyl taurate, magnesium methyl cocoyl taurate, sodium methyltaurate isopalmitamide and mixtures thereof. Still other examples of taurate surfactants include sodium methyltaurine cocoyl methyltaurate and sodium taurine cocoyl methyltaurate.

In an embodiment, the taurate surfactants are compounds in which R² is a methyl group and R¹ has 12 to 18 carbon atoms, such as, for example, sodium methyl oleyl taurate, sodium methyl cocoyl taurate and combinations thereof. In an embodiment, the taurate surfactant is sodium methyl oleyl taurate.

In some embodiments, the taurate-based and/or isethionate-based surfactant has an alkyl chain comprising no double bond. In some embodiments, the taurate-based and/or isethionate-based surfactant has an aliphatic chain comprising no double bond.

In some embodiments, the taurate-based and/or isethionate-based surfactant has an alkyl chain comprising at least one double bond. In some embodiments, the taurate- based and/or isethionate-based surfactant has an aliphatic chain comprising at least one double bond.

In some embodiments, the taurate-based surfactant having aliphatic chain comprising at least one double bond is methyl oleoyl taurate or a salt thereof. In some embodiments, the methyl oleoyl taurate is a sodium salt thereof.

In some embodiments, the taurate-based surfactant is methyl oleoyl taurate.

In some embodiments, the methyl oleoyl taurate is Geropon T-77.

In some embodiments, the composition comprises an isethionate-based surfactant. In some embodiments, the surfactant is an isethionate-based surfactant. In some embodiments, the isethionate-based surfactant is Hostapon SCI - sodium cocoyl isethionate.

In some embodiments, the composition comprises two or more fungicides (I). In some embodiments, the composition comprises two fungicides (I).

In some embodiments, when the composition comprises two or more fungicides (I), at least one fungicide (I) is dissolved in the water immiscible carrier and at least one fungicide (I) is suspended in water.

In some embodiments, when the composition comprises two or more fungicides (I), at least two fungicides (I) are dissolved in the water immiscible carrier.

In some embodiments, the amount of the copper-based fungicide in the composition is 1-50% by weight based on the total weight of the composition. In some embodiments, the amount of the copper-based fungicide in the composition is 5-40% by weight based on the total weight of the composition. In some embodiments, the amount of the copperbased fungicide in the composition is 5-18% by weight based on the total weight of the composition.

In some embodiments, the amount of fungicide(s) (I) in the composition is 1-50% by weight based on the total weight of the composition. In some embodiments, the amount of fungicide(s) (I) in the composition is 1-30% by weight based on the total weight of the composition. In some embodiments, the amount of fungicide(s) (I) in the composition is 1-20% by weight based on the total weight of the composition. In some embodiments, the amount of fungicide(s) (I) in the composition is 1-15% by weight based on the total weight of the composition.

In some embodiments, the amount of the strobilurin fungicide in the composition is 1 - 15% by weight based on the total weight of the composition. In some embodiments, the amount of the strobilurin fungicide in the composition is 1-5% by weight based on the total weight of the composition. In some embodiments, the amount of the strobilurin fungicide in the composition is 5-10% by weight based on the total weight of the composition. In some embodiments, the amount of the strobilurin fungicide in the composition is 10-15% by weight based on the total weight of the composition. In some embodiments, the amount of the azole fungicide in the composition is 1-20% by weight based on the total weight of the composition. In some embodiments, the amount of the azole fungicide in the composition is 1-5% by weight based on the total weight of the composition. In some embodiments, the amount of the azole fungicide in the composition is 5-10% by weight based on the total weight of the composition. In some embodiments, the amount of the azole fungicide in the composition is 10-15% by weight based on the total weight of the composition. In some embodiments, the amount of the azole fungicide in the composition is 15 -20% by weight based on the total weight of the composition.

In some embodiments, the amount of the succinate dehydrogenate inhibitor fungicide (SDHI) in the composition is 1-15% by weight based on the total weight of the composition. In some embodiments, the amount of the succinate dehydrogenate inhibitor fungicide (SDHI) in the composition is 1-5% by weight based on the total weight of the composition. In some embodiments, the amount of the succinate dehydrogenate inhibitor fungicide (SDHI) in the composition is 5-10% by weight based on the total weight of the composition. In some embodiments, the amount of the succinate dehydrogenate inhibitor fungicide (SDHI) in the composition is 10-15% by weight based on the total weight of the composition.

In some embodiments, the amount of the benzamide fungicide in the composition is 1 - 50% by weight based on the total weight of the composition.

In some embodiments, the amount of the morpholine(s) in the composition is 1-50% by weight based on the total weight of the composition.

In some embodiments, the amount of the Qil fungicide in the composition is 1-50% by weight based on the total weight of the composition.

In some embodiments, the copper-based fungicide is Bordeaux mixture.

In some embodiments, the composition comprises 5-18% by weight of the Bordeaux mixture, 1-15% by weight of the strobilurin fungicide, and 1-20% by weight of the azole fungicide. In some embodiments, the composition comprises 5-18% by weight of the Bordeaux mixture, and 1-20% by weight of the azole fungicide.

In some embodiments, the composition comprises 5-18% by weight of the Bordeaux mixture, 1-20% by weight of the azole fungicide, and 1-15% by weight of the SDHI.

In some embodiments, the composition comprises 5-18% by weight of the Bordeaux mixture and 1-15% by weight of the strobilurin fungicide.

In some embodiments, the composition comprises 5-18% by weight of the Bordeaux mixture and 1-15% by weight of the SDHI.

In some embodiments, the copper-based fungicide is copper oxychloride.

In some embodiments, the composition comprises 5-40% by weight of copper oxychloride, 1-15% by weight of the strobilurin fungicide, and 1-20% by weight of the azole fungicide.

In some embodiments, the composition comprises 5-40% by weight of copper oxychloride, and 1-20% by weight of the azole fungicide.

In some embodiments, the composition comprises 5-40% by weight of copper oxychloride, 1-20% by weight of the azole fungicide, and 1-15% by weight of the SDHI.

In some embodiments, the composition comprises 5-40% by weight of copper oxychloride and 1-15% by weight of the strobilurin fungicide.

In some embodiments, the composition comprises 5-40% by weight of copper oxychloride and 1-15% by weight of the SDHI.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier, and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is copper oxychloride (2) the strobilurin fungicide is picoxystrobin (3) the azole fungicide is prothioconazole, (4) the copper-based fungicide and strobilurin fungicide are suspended in the water and (5) the azole fungicide is dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier, and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is Bordeaux mixture (2) the strobilurin fungicide is picoxystrobin (3) the azole fungicide is prothioconazole (4) the copper-based fungicide and the strobilurin fungicide are suspended in the water and (5) the azole fungicide is dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water , (v) a water immiscible carrier and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is copper oxychloride, (2) the strobilurin is picoxystrobin, (3) the azole fungicide is tebuconazole, (4) the copper-based fungicide and strobilurin fungicide are suspended in the water, and (5) the azole fungicide is dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is Bordeaux mixture, (2) the strobilurin is picoxystrobin, (3) the azole fungicide is tebuconazole, (4) the copper-based fungicide and strobilurin fungicide are suspended in the water, and (5) the azole fungicide is dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is copper oxychloride, (2) the strobilurin is azoxystrobin, (3) the azole fungicide is prothioconazole, (4) the copper-based fungicide and strobilurin fungicide are suspended in the water, and (5) the azole fungicide is dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) water immiscible carrier and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is Bordeaux mixture, (2) the strobilurin is azoxystrobin, (3) the azole fungicide is prothioconazole, (4) the copper-based fungicide and strobilurin fungicide are suspended in the water, and (5) the azole fungicide is dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier, and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is copper oxychloride, (2) the strobilurin fungicide is azoxystrobin, (3) the azole fungicide is tebuconazole, (4) the copper-based fungicide and the strobilurin fungicide are suspended in the water, and (5) the azole fungicide is dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) copper-based fungicide, (ii) strobilurin, (iii) azole fungicide, (iv) water, (v) water immiscible carrier and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is Bordeaux mixture (2) the strobilurin is azoxystrobin (3) the azole fungicide is tebuconazole (4) the copperbased fungicide and strobilurin are suspended in the water and (5) the azole fungicide is dissolved in the water-immiscible carrier. In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier, and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is copper oxychloride, (2) the strobilurin fungicide is picoxystrobin, (3) the azole fungicide is prothioconazole, (4) the copper-based fungicide is suspended in the water, and (5) the azole fungicide and the strobilurin fungicide are dissolved in the water- immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is Bordeaux mixture, (2) the strobilurin is picoxystrobin, (3) the azole fungicide is prothioconazole, (4) the copper-based fungicide is suspended in the water, and (5) the azole fungicide and the strobilurin fungicide are dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is copper oxychloride, (2) the strobilurin is picoxystrobin, (3) the azole fungicide is tebuconazole, (4) the copper-based fungicide is suspended in the water, and (5) the azole fungicide and strobilurin are dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier, and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is Bordeaux mixture, (2) the strobilurin fungicide is picoxystrobin, (3) the azole fungicide is tebuconazole, (4) the copper-based fungicide is suspended in the water, and (5) the azole fungicide and the strobilurin fungicide are dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier, and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is copper oxychloride, (2) the strobilurin is azoxystrobin, (3) the azole fungicide is prothioconazole, (4) the copper-based fungicide is suspended in the water, and (5) the azole fungicide and the strobilurin fungicide are dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is Bordeaux mixture, (2) the strobilurin fungicide is azoxystrobin, (3) the azole fungicide is prothioconazole, (4) the copper-based fungicide is suspended in the water, and (5) the azole fungicide and the strobilurin fungicide are dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier, and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is copper oxychloride, (2) the strobilurin fungicide is azoxystrobin, (3) the azole fungicide is tebuconazole, (4) the copper-based fungicide is suspended in the water, and (5) the azole fungicide and the strobilurin fungicide are dissolved in the water-immiscible carrier.

In another preferred embodiment, the subject matter relates to a composition comprising: (i) a copper-based fungicide, (ii) a strobilurin fungicide, (iii) an azole fungicide, (iv) water, (v) a water immiscible carrier and (vi) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein (1) the copper-based fungicide is Bordeaux mixture, (2) the strobilurin fungicide is azoxystrobin, (3) the azole fungicide is tebuconazole, (4) the copper-based fungicide is suspended in the water, and (5) the azole fungicide and the strobilurin fungicide are dissolved in the water-immiscible carrier.

In some embodiments, the copper-based fungicide is Bordeaux mixture, and the fungicides (I) are prothioconazole and picoxystrobin.

In some embodiments, when the copper-based fungicide is Bordeaux mixture, the fungicides (I) are prothioconazole and picoxystrobin, and if the composition further comprises thiourea, sodium thiosulfate and/or ethylene diamine the taurate based surfactant is no methyl oleyl taurate.

In some embodiments, the copper-based fungicide is Bordeaux mixture, and the fungicides (I) are prothioconazole and azoxystrobin.

In some embodiments, the copper-based fungicide is Bordeaux mixture, and the fungicides (I) are tebuconazole and picoxystrobin.

In some embodiments, the copper-based fungicide is Bordeaux mixture, and the fungicides (I) are tebuconazole and azoxystrobin.

In some embodiments, the copper-based fungicide is Bordeaux mixture, and the fungicides (I) are prothioconazole and fluxapyroxad.

In some embodiments, the copper-based fungicide is copper oxychloride, and the fungicides (I) are prothioconazole and picoxystrobin.

In some embodiments, the copper-based fungicide is copper oxychloride, and the fungicides (I) are prothioconazole and azoxystrobin. In some embodiments, the copper-based fungicide is copper oxychloride, and the fungicides (I) are tebuconazole and picoxystrobin.

In some embodiments, the copper-based fungicide is copper oxychloride, and the fungicides (I) are tebuconazole and azoxystrobin.

In some embodiments, the copper-based fungicide is copper oxychloride, and the fungicide (I) are prothioconazole and fluxapyroxad.

In some embodiments, the composition further comprises at least one acceptable additive.

In some embodiments, the composition has viscosity in the range of 700-2000 cPs (measured with a Brookfield viscometer, spindle 63 at 30 rpm).

In some embodiments, the composition has viscosity in the range of 700-1500 cPs (measured with a Brookfield viscometer, spindle 63 at 30 rpm).

In some embodiments, the composition exhibits improved stability compared to compositions not comprising taurate-based surfactants, isethionate-based surfactants, or any combination thereof.

In some embodiments, the composition exhibits less than 5% phase separation after two weeks of storage.

In some embodiments the composition exhibits less than 5% phase separation after two weeks of storage and/or has viscosity in the range of 700-2000 cPs and/or has viscosity in the range of 700-1500 cPs.

In some embodiments, the present invention provides a taurate-based surfactants, an isethionate-based surfactants, or any combination thereof for reducing the extent of phase separation and/or for decreasing the viscosity of a suspoemulsion comprising a copper-based fungicide. In some embodiments, the phase separation of the compositions of the invention is lower that the phase separation of the same compositions without the taurate-based and/or the isethionate-based surfactants. In some embodiments, the phase separation is lowered by at least 5%, at least 10%, or at least 20%.

In some embodiments, the viscosity of the compositions of the invention is lower that the viscosity of the same compositions without the taurate-based and/or the isethionate- based surfactants. In some embodiments, the viscosity is lowered by at least 5%, at least 10%, or at least 20%.

In some embodiments, the viscosity and/or the phase separation of the compositions of the invention is reduced in comparison with similar compositions which do not contain isethionate and/or taurate-based surfactants.

In some embodiments, the viscosity of the compositions of the inventions is reduced by more than 5%, more than 10%, more than 20% in comparison with similar compositions which do not contain isethionate and/or taurate-based surfactants.

In some embodiments, the phase separation of the compositions of the inventions is reduced by more than 5%, more than 10%, more than 20% in comparison with similar compositions which do not contain isethionate and/or taurate-based surfactants.

Similar compositions refer to compositions comprising the same type of copper-based fungicide, and/or water and/or water immiscible carrier in the same amounts. In compositions comprising one or more polyelectrolyte, a similar composition comprises the same type(s) of polyelectrolyte in the same amount(s).

In some embodiments, the composition comprises particles with a particle size distribution (d90) is 10 microns or less. In some embodiments, the composition comprises particles with a particle size distribution (d90) is 7 microns or less. In some embodiments, the composition comprises particles with a particle size distribution (d90) of 4 microns or less.

In some embodiments, the composition has a pH in the range of 4.0-7.5.

In some embodiments, the composition has a density (g/ml) of 1.4± 0.05 at 25 °C. In some embodiments, the concentration of the copper-based fungicide is up to 40% by weight based on the total weight of the composition. In some embodiments, the concentration of the copper-based fungicide is 10% by weight based on the total weight of the composition. In some embodiments, the concentration of the copper-based fungicide in the composition is between 100 and 250 g/L, preferably 125 g/L.

In some embodiments, the concentration of the metallic copper in the formulation comprising the copper-based fungicide is between 10 g/L to 250 g/L. In some embodiments, the concentration of the metallic copper in the formulation comprising the copper-based fungicide is between 50 g/L to 150 g/L. In some embodiments, the concentration of the metallic copper in the formulation comprising the copper-based fungicide is 100 g/L.

In some embodiments, the concentration of the metallic copper in the formulation comprising the copper-based fungicide is 1-25% by weight based on the total weight of the formulation. In some embodiments, the concentration of the metallic copper in the formulation comprising the copper-based fungicide is 5-25% by weight based on the total weight of the formulation. In some embodiments, the concentration of the metallic copper in the formulation comprising the copper-based fungicide is 5-15% by weight based on the total weight of the formulation. In some embodiments, the concentration of the metallic copper in the formulation comprising the copper-based fungicide is about 10% by weight based on the total weight of the formulation. In some embodiments, the concentration of the metallic copper in the formulation comprising the copper-based fungicide is 10.1% by weight based on the total weight of the formulation.

In some embodiments, the concentration of the metallic copper in the formulation comprising the copper-based fungicide is up to 25% by weight based on the total weight of the formulation. In some embodiments, the concentration of the metallic copper in the formulation comprising the copper-based fungicide is 10% by weight based on the total weight of the formulation.

In some embodiments, the concentration of the metallic copper in the formulation comprising the copper-based fungicide is between 100 and 250 g/L, preferably 110 g/L. In some embodiments, the concentration of the copper-based fungicide in the composition is between 15% to 45% by weight based on the total weight of the composition. In some embodiments, the concentration of the copper-based fungicide in the composition is between 20% to 35% by weight based on the total weight of the composition. In some embodiments, the concentration of the copper-based fungicide in the composition is between 25% to 30% by weight based on the total weight of the composition. In some embodiments, the concentration of the copper-based fungicide in the composition is 28.8% by weight based on the total weight of the composition.

In some embodiments, the concentration of the formulation comprising the copperbased fungicide in the composition is between 150 and 500 g/L. In some embodiments, the concentration of the formulation comprising the copper-based fungicide in the composition is between 300 g/L to 400 g/L. In some embodiments, the concentration of the formulation comprising the copper-based fungicide in the composition is 345 g/L.

In some embodiments, the concentration of the metallic copper in the composition is 0.1% to 10% by weight based on the total weight of the composition. In some embodiments, the concentration of the metallic copper in the composition is 0.5% to 5% by weight based on the total weight of the composition. In some embodiments, the concentration of the metallic copper in the composition is 2% to 3% by weight based on the total weight of the composition. In some embodiments, the concentration of the metallic copper in the composition is 2.9% by weight based on the total weight of the composition.

In some embodiments, the concentration of the additional fungicide in the composition is between 1% to 10% by weight based on the total weight of the composition. In some embodiments, the concentration of the azole fungicide in the composition is between 2% to 8% by weight based on the total weight of the composition. In some embodiments, the concentration of the azole fungicide in the composition is between 2.5% to 6% by weight based on the total weight of the composition. In some embodiments, the concentration of the azole fungicide in the composition is 3% by weight based on the total weight of the composition.

In some embodiments, the composition further comprises acceptable additive. In some embodiments, the agriculturally acceptable additive is selected from buffers, acidifiers, antifoaming agents, anti-freeze agents, solvents, co-solvents, agents, light agents, UV absorbers, radical scavengers and antioxidants, adhesives, neutralizers, thickeners, binders, sequestrates, biocides, drift retardants, surfactants, dispersants, pigments, wetting agents, safeners, and preservatives. Said additives include, but are not limited to, surfactants, pigments, wetting agents, as well as safeners, or such preservatives as bacteriostats or bactericides.

The addition of small amounts of one or more agriculturally acceptable additives may affect parameters such as efficacy and/or rainfastness of a composition according to the invention. The addition of small amounts of one or more agriculturally acceptable carriers preferably increases efficacy and/or rainfastness of a composition according to the invention.

In some embodiments, the composition comprises 40-80% by weight of water. In some embodiments, the composition comprises 50-70% by weight of water. In some embodiments, the composition comprises 50-55% by weight of water. In some embodiments, the composition comprises about 52% by weight of water. In some embodiments, the composition comprises about 53% by weight of water. In some embodiments, the composition comprises about 54% by weight of water. In some embodiments, the composition comprises about 55% by weight of water.

In some embodiments, the composition is an aqueous composition.

In some embodiments, the composition is a suspoemulsion.

In some embodiments, the continuous phase is an aqueous phase.

In some embodiments, the composition further comprises one or more polyelectrolyte.

In some embodiments, the one or more polyelectrolytes are as described in PCI7IB2021/061258.

In some embodiments, the polyelectrolyte is a polyanionic compound.

In some embodiments the polyelectrolyte is a lignosulfonate polyelectrolyte.

In some embodiments, the copper-based fungicide is suspended in the water. In an embodiment, the amount of the fungicide (I) may be present in a concentration of about 0.1-30 wt. %, based on the total weight of the composition. In a further embodiment, the amount of the fungicide (I) may be present in a concentration of about 1-15% by weight based upon the total weight of the composition. In another embodiment, the amount of the fungicide (I) may be present in a concentration of about 1-10% by weight based upon the total weight of the composition. In yet another embodiment, the amount of the fungicide (I) may be present in a concentration of about 3-8% by weight based upon the total weight of the composition. In a specific embodiment, the amount of the fungicide (I) may be present in a concentration of about 5.6% by weight based upon the total weight of the composition.

In some embodiments, the water-immiscible carrier is selected from the group consisting of N-mono, di alkylated fatty acid amide (N,N-dimethyl octanamide, N,N- dimethyl decanamide) like Genagen 4296, Genagen 4266, Rhodiasolv ADMA 810, Rhodiasolv ADMA 10, and any combination thereof.

In some embodiments, the water immiscible carrier is selected from the group consisting of Rhodiaslov Match 111, Rhodiasolv RPDE, N-octylpyrrolidone, N-butyl pyrrolidone, N,N-dimethyl octanamide, N,N-dimethyl decanamide like Genagen 4296, Genagen 4266, Rhodiasolv ADMA 810, Rhodiasolv ADMA 10, and any combination thereof.

Rhodiasolv RPDE is a dibasic ester solvent blend.

In some embodiments, water immiscible carrier may include but is not limited to aromatic hydrocarbons (e.g. toluene, o-, m-, p-xylene, ethylbenzene, isopropylbenzene, tert-butylbenzene, naphthalenes, mono- or polyalkyl-substituted naphthalenes), paraffins (e.g. octane, nonane, decane, undecane, dodecane, tridecane, tetradecane, pentadecane, hexadecane, hepta-decane, octa-decane, nona-decane, eicosane, heneicosane, docosane, tricosane, tetracosane, pentacosane, and branched chain isomers thereof), petroleum, ketones (e.g. acetophenone, cyclohexanone), vegetable oil (e.g. olive oil, kapok oil, castor oil, papaya oil, camellia oil, palm oil, sesame oil, com oil, rice bran oil, peanut oil, cotton seed oil, soybean oil, rapeseed oil, linseed oil, tung oil, sunflower oil, safflower oil, tall oil), alkyl ester of vegetable oils, (e.g. rapeseed oil methyl ester or rapeseed oil ethyl ester, rapeseed oil propyl esters, rapeseed oil butyl esters, tall oil fatty acids esters etc...), diesel, mineral oil, fatty acid amides (e.g. C1-C3 amines, alkylamines or alkanolamines with G, - Cis carboxylic acids), fatty acids, tall oil fatty acids, alkyl esters of fatty acids (e.g. Ci- C4 monohydric alcohol esters of Cx to C22 fatty acids such as methyl oleate, ethyl oleate), modified vegetable oils and combinations thereof.

In a preferred embodiment, the water immiscible carrier may include but is not limited to aromatic hydrocarbons, fatty acid amides, alkyl ester of vegetable oils and vegetable oils.

In an embodiment, the amount of the water immiscible carrier may be about 0.1-20 wt. %, about 1-15 wt. %, or about 0.1-10 wt. %, or about 1-5% based on the total weight of the composition.

In a specific embodiment, the non-aqueous liquid carrier may be present in a concentration of about 3% by weight based upon the total weight of the composition.

In some embodiments, the composition further comprises an adjuvant.

In some embodiments, the adjuvant in the liquid carrier may include but is not limited to vegetable oils, alkyl esters of vegetable oils such as for example, soy methyl ester, soy ethyl ester, rapeseed oil methyl ester or rapeseed oil ethyl ester, alkoxylated sorbitan esters such as for example sorbitan monolaurate alkoxylates such as for example polyoxyethylene (16) sorbitan monolaurate (Tween™ 24), polyoxyethylene (20) sorbitan monolaurate (Tween™ 20; Alkamuls® PSML-20), polyoxyethylene (4) sorbitan monolaurate (Tween™ 21), polyoxyethylene (8) sorbitan monolaurate (Tween™ 22), polyoxyethylene (12) sorbitan monolaurate (Tween™ 23), sorbitan monolaurate (Alkamuls® S/20, Glycomul® LK, Glycomul® LC, Span® 20), polyoxyethylene (20) sorbitan monostearate alkoxylates such as for example polyoxyethylene (20) sorbitan monostearate (Tween™ 60), polyoxyethylene (4) sorbitan monostearate (Tween™ 61), sorbitan monostearate (Alkamuls® S/90, Glycomul® S, Span® 60), sorbitan monooleate alkoxylates such as for example polyoxyethylene (20) sorbitan monooleate (Tween™ 80, Emulgin® SMO 20, T-Maz® 80, Agnique® SMO 20U), polyoxyethylene (5) sorbitan monooleate (Tween™ 81), sorbitan monooleate (Alkamuls® S/80, Span® 80), and combinations thereof. In some embodiments, the composition further comprises an additional surfactant.

In some embodiments, the surfactant is a wetting agent, dispersant, or a combination thereof.

In some embodiments, the composition further comprises at least one dispersant, wherein the at least one dispersant is an anionic polymeric surfactant.

In some embodiments, the dispersant is an anionic polymeric surfactant.

In some embodiments, the anionic polymeric surfactant comprises sulfonate groups.

In some embodiments, the anionic polymeric surfactant comprises phosphonate groups.

In some embodiments, the anionic polymeric surfactant comprises sulfate groups.

In some embodiments, the anionic polymeric surfactant comprises phosphate groups.

In some embodiments, the anionic polymeric surfactant comprises carboxylate groups.

In some embodiments, the anionic polymeric surfactant is Metasperse 500L.

In some embodiments, the anionic polymeric surfactant is sodium lignosulfonate.

In some embodiments, the anionic polymeric surfactant is Borresperse CA.

In some embodiments, the dispersant is an anionic dispersant.

In some embodiments, the dispersant is a nonionic dispersant. In some embodiments, the nonionic dispersant is Atlox 4894 (fatty alcohol ethoxylate mixture).

In some embodiments, the surfactant has HLB of above 13.

A composition of the invention may also comprise two or more different dispersants. A dispersant is preferably present in an amount of between 0 to up to 10% (w/v), more preferred between 0.01 to up to 5 % (w/v), more preferred between 0.02 to up to 2 % (w/v),

In some embodiments, the dispersant is a modified acrylic polymer, non-modified acrylic acid or any combination thereof. In some embodiments, the modified acrylic polymer is modified styrene acrylic acid, polymethyl methacrylate -polyethylene glycol graft copolymer or any combination thereof. In some embodiments, modified acrylic polymer is modified styrene acrylic polymer. In some embodiments, the modified styrene acrylic polymer is Atlox Metasperse™ 500L. Metasperse 550S (sold by Croda). In some embodiments, the modified acrylic polymer is polymethyl methacrylate -polyethylene glycol graft copolymer.

In some embodiments, the concentration of the dispersant in the composition is 0.01- 15% by weight based on the total weight of the composition.

In some embodiments, the concentration of the dispersant in the composition is 0.01- 12% by weight based on the total weight of the composition. In some embodiments, the concentration of the dispersant in the composition is 1-12% by weight based on the total weight of the composition. In some embodiments, the concentration of the dispersant in the composition is 0.01-10% by weight based on the total weight of the composition. In some embodiments, the concentration of the dispersant in the composition is 1-5% by weight based on the total weight of the composition. In some embodiments, the concentration of the dispersant in the composition is 5-10% by weight based on the total weight of the composition. In some embodiments, the concentration of the dispersant is about 2% by weight based on the total weight of the composition. In some embodiments, the concentration of the dispersant is about 5% by weight based on the total weight of the composition. In some embodiments, the concentration of the dispersant is about 6% by weight based on the total weight of the composition. In some embodiments, the concentration of the dispersant is about 7% by weight based on the total weight of the composition. In some embodiments, the concentration of the dispersant is about 8% by weight based on the total weight of the composition. In some embodiments, the concentration of the dispersant is about 9% by weight based on the total weight of the composition. In some embodiments, the concentration of the dispersant is about 10% by weight based on the total weight of the composition.

A composition according to the invention may further comprise at least one pH adjuster or buffering agent such as organic or inorganic bases and/or organic or inorganic acids. In some embodiments, the composition comprises one or more additives such as biocide (preservative) defoaming agents, thickeners and drift retardants.

Weting agent can be selected from di-octylsulfosuccinate, alcohol alkoxylate, polyoxyethylene/polypropylene block copolymers and mon/di/tri-styryl sulphonate/phosphate. A composition of the invention may also comprise two or more different weting agents. A weting compound (I) is preferably present in an amount of between 0 to up to 10% (w/v), more preferred between 0.01 to up to 5 % (w/v), more preferred between 0.02 to up to 1 % (w/v), more preferred about 0.05 % (w/v).

In some embodiments, the weting agent is polyalkylene oxide block copolymer. In some embodiments, the weting compound (I) is butyl block copolymer. In some embodiments, the butyl block copolymer is Atlas™ G5002L (sold by Croda).

In some embodiments, the concentration of the weting agent in the composition is 1 - 10% by weight based on the total weight of the composition. In some embodiments, the concentration of the weting agent in the composition is 0-5% by weight based on the total weight of the composition. In some embodiments, the concentration of the weting agent in the composition is 1-5% by weight based on the total weight of the composition. In some embodiments, the concentration of the weting agent in the composition is 1-3% by weight based on the total weight of the composition. In some embodiments, the concentration of the weting agent in the composition is about 2% by weight based on the total weight of the composition.

In some embodiments, the composition comprises at least one rheology modifier. In some embodiments, the agriculturally acceptable additive is a rheology modifier.

In some embodiments, the rheology modifier is a thickener. In some embodiments, the composition comprises at least one thickener.

A thickening agent, when present, is preferably selected from agar, alginic acid, alginate, carrageenan, gellan gum, xanthan gum, succinoglycan gum, guar gum, acetylated distarch adipate, acetylated oxidized starch, arabinogalactan, ethyl cellulose, methyl cellulose, locust bean gum, starch sodium octenylsuccinate, and triethyl citrate. A composition of the invention may also comprise two or more different thickening agents. A thickening compound (I) is preferably present in an amount of between 0 to up to 10% (w/v), more preferred between 0.01 to up to 5 % (w/v), more preferred between 0.02 to up to 1 % (w/v), more preferred about 0.1 % (w/v).

In some embodiments, the thickener is xanthan gum.

In some embodiments, the rheology modifier is Rhodopol® 23 (sold by Solvay). In some embodiments, the rheology modifier is xanthan gum.

In some embodiments, the defoamer is SAG 1572

In some embodiments, the concentration of the rheology modifier in the composition is 0.01-10% by weight based on the total weight of the composition. In some embodiments, the concentration of the rheology modifier in the composition is 5-10% by weight based on the total weight of the composition. In some embodiments, the concentration of the rheology modifier in the composition is about 6% by weight based on the total weight of the composition. In some embodiments, the concentration of the rheology modifier in the composition is about 8% by weight based on the total weight of the composition.

In some embodiments, the composition comprises at least one thickener and at least one biocide. In some embodiments, the amount of the thickener and the biocide in the composition is up to 1% by weight based on the total weight of the composition.

In some embodiments, the agriculturally acceptable additive is a preservative. In some embodiments, the composition comprises at least one preservative.

In some embodiments, the preservative is a biocide. In some embodiments, the composition comprises at least one biocide. In some embodiments, the preservative is Acticide® MBS.

In some embodiments, the concentration ofthe preservative in the composition is 0.01- 5% by weight based on the total weight of the composition. In some embodiments, the concentration ofthe preservative in the composition is 0.01-1% by weight based on the total weight of the composition. In some embodiments, the concentration of the preservative in the composition is about 0.1% by weight based on the total weight of the composition. In some embodiments, the concentration of the preservative in the composition is 0.083% by weight based on the total weight of the composition. A composition according to the invention may comprise an additional bioactive ingredient, also termed additional agrochemical, such as a growth regulator, a biostimulant, a fungicide, an herbicide, an insecticide, an acaricide, a molluscicide, a miticide, a rodenticide; and/or an bactericide.

Various agrochemicals may be used as additional bioactive ingredient. Exemplary among such agrochemicals without limitation are crop protection agents, for example pesticides, safeners, plant growth regulators, repellents, bio-stimulants and preservatives such as bacteriostats or bactericides.

In some embodiments, the composition comprises at least one additional bioactive ingredient, preferably an additional insecticide, fungicide and/or herbicide.

Additional agrochemicals that may be used with the combination and composition of the present invention are described below.

A composition of the invention may also comprise additional bioactive ingredients.

Said additional bioactive ingredient preferably is an insecticide, a fungicide and/or an herbicide.

In some embodiments, the composition is other than the SE composition exemplified in PCT International Application No. PCT/IB2021/061258.

In some embodiments, the composition is other than a composition consisting of: a) Bordeaux mix, b) picoxystrobin, c) propylene glycol, d) Metasperse 550 S, e) Borresperse CA, f) Geropon T-77, g) Atlox 4894, h) SAG 1572, i) Proxel GXL, j) DM water, k) prothioconazole, l) Armid DM 10, m) Emulsogen TS 200, n) TEA, and o) Rhodopol 23 (2%).

In some embodiments, the composition is other than a composition consisting of: a) 34.29% w/w of bodeaux mix (9.4 at 27.22), b) 2.78% w/w of picoxystrobin (2.7 at 97), c) 5% w/w of propylene glycol, d) 1 % w/w of Metasperse 550 S , e) 2.8% w/w of Borresperse CA, f) 2% w/w of Geropon T-77, g) 2% w/w of Atlox 4894, h) 0.1% w/w of SAG 1572, i) 0.05% w/w of Proxel GXL, j) 36.86% w/w of DM water, k) 3.06% w/w of prothioconazole, l) 3.06% w/w of Armid DM 10, m) 1.5% w/w of Emulsogen TS 200, n) 0.5% w/w of TEA, and o) 5% w/w of Rhodopol 23 (2%).

In some embodiments, the composition is other than a composition consisting of: a. 34.29 % by weight of Bordeaux Mixture b. 2.78% by weight of Picoxystrobine c. 5.0% by weight of propane- 1,2-diol, d. 1.0% by weight of Metasperse 550 S, e. 2.8% by weight of Borresperse CA f. 2% by weight of Geropon® T-77, g. 2.0% by weight of Atlox 4894 h. 0.1 % by weight of SAG 1572, i. 0.05% by weight of Proxel GXL, j. 36.86% by weight of DM water, k. 3.06% by weight of prothioconazole and l. 3.06% by weight of Armid DM 10.

In some embodiments, the composition is other than a composition consisting of:

(1) 34.53% by weight of Bordeaux Mixture,

(2) 2.7 % by weight of Picoxystrobin,

(3) 5 % by weight of Propylene Glycol,

(4) 2 % by weight of Geropon T-77,

(5) 1% by weight of Borresperse CA,

(6) 1 % by weight of Atlox Metasperse 500L,

(7) 3% by weight of Atlox 4894,

(8) 0.1 % by weight of SAG 1572,

(9) 0.2 % by weight of Proxel GXL,

(10) 2 % by weight of ethylene diamine,

(11) 3 % by weight of Prothioconazole,

(12) 3 % by weight of Rhodiasolv ADMA 10,

(13) 1.5 % by weight of Emulsogen TS 200,

(14) 0.2 % by weight of Agrhopol 23, and

(15) 39.77 % by weight of water.

In some embodiments, the composition is other than a composition consisting of:

(1) 34.53% by weight of Bordeaux Mixture,

(2) 2.7 % by weight of Picoxystrobin,

(3) 5 % by weight of Propylene Glycol,

(4) 2 % by weight of Geropon T-77,

(5) 1% by weight of Borresperse CA,

(6) 1 % by weight of Atlox Metasperse 500L,

(7) 3% by weight of Atlox 4894, (8) 0.1 % by weight of SAG 1572,

(9) 0.2 % by weight of Proxel GXL,

(10) 1 % by weight of sodium thiosulphate,

(11) 0.5% by weight of thiourea,

(12) 3 % by weight of Prothioconazole,

(13) 3 %by weight of Rhodiasolv ADMA 10,

(14) 1.5 % by weight of Emulsogen TS 200,

(15) 0.2 % by weight of Agrhopol 23, and

(16) 41.27 % by weight of water.

In some embodiments, the composition is other than a composition consisting of:

The present invention provides a composition comprising

(1) 34.53% by weight of Bordeaux Mixture,

(2) 2.7 % by weight of Picoxystrobin,

(3) 5 % by weight of Propylene Glycol,

(4) 2 % by weight of Geropon T-77,

(5) 1% by weight of Borresperse CA,

(6) 1 % by weight of Atlox Metasperse 500L,

(7) 3% by weight of Atlox 4894,

(8) 0.1 % by weight of SAG 1572,

(9) 0.2 % by weight of Proxel GXL,

(10) 0.32 % by weight of thiourea,

(11) 3 % by weight of Prothioconazole,

(12) 3 % by weight of Rhodiasolv ADMA 10,

(13) 1.5 % by weight of Emulsogen TS 200, (14) 0.2 % by weight of Agrhopol 23, and

(15) 42.45 % by weight of Water.

In some embodiments, the composition is other than a composition comprising (1) a copper-based fungicide, (2) azole fungicide, (3) a compatibility agent selected from the group consisting of thiourea-based compound, sodium thiosulfate, alkyl amine, thioamide-based compound, and any combination thereof, and (4) methyl -oleyl taurate.

In some embodiments, the composition is a composition comprising (1) a copper-based fungicide, (2) azole fungicide, (3) a water immiscible carrier, and (4) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate- based surfactants and any combination thereof, wherein if the composition further comprises a compound selected from the group consisting of thiourea-based compound, sodium thiosulfate, alkyl amine, thioamide-based compound, and any combination thereof, then the surfactant (4) is different from methyl-oleyl taurate.

In some embodiments, the composition is other than a composition comprising (1) a copper-based fungicide, (2) azole fungicide, (3) a compatibility agent selected from the group consisting of thiourea-based compound, sodium thiosulfate, alkyl amine, thioamide-based compound, and any combination thereof, (4) water, and (5) methyloleyl taurate.

In some embodiments, the composition is a composition comprising (1) a copper-based fungicide, (2) azole fungicide, (3) a water immiscible carrier, (4) water, and (5) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein if the composition further comprises a compound selected from the group consisting of thiourea-based compound, sodium thiosulfate, alkyl amine, thioamide-based compound, and any combination thereof, then the surfactant (4) is different from methyl-oleyl taurate.

In some embodiments, the composition comprises less than 0.49% of triethanolamine or is devoid of triethanolamine.

In some embodiments, the composition comprises less than 5% of xanthan gum, preferably less than 1%, preferably 0.2% or less. The present invention provides a composition comprising: a) 34.53% by weight of Bordeaux Mixture b) 2.70% by weight of Picoxystrobin c) 5.00% by weight of Propylene Glycol d) 2.00% by weight of Geropon T-77 e) 1.00% by weight of Borresperse CA f) 1.00% by weight of Atlox Metasperse 500L g) 3.00% by weight of Atlox 4894 h) 0.10% by weight of SAG 1572 i) 0.10% by weight of Proxel GXL j) 3.00% by weight of Prothioconazole k) 3.00% by weight of Rhodiasolv ADMA 10 l) 1.50% by weight of Emulsogen TS 200 m) 0.20% by weight of Agrhopol 23 n) Water to 100%

The present invention provides a composition comprising: a) 34.53% by weight of Bordeaux Mixture b) 2.70% by weight of Picoxystrobin c) 5.00% by weight of Propylene Glycol d) 2.00% by weight of Geropon T-77 e) 1.00% by weight of Borresperse CA f) 1.00% by weight of Atlox Metasperse 500L g) 3.00% by weight of Atlox 4894 h) 0.10% by weight of SAG 1572 i) 0.10% by weight of Proxel GXL j) 2% by weight of ethylene diamine, or 0.32% by weight of thiourea, or a mixture of sodium thiosulphate and thiourea 1% + 0.5% by weight k) 3.00% by weight of Prothioconazole l) 3.00% by weight of Rhodiasolv ADMA 10 m) 1.50% by weight of Emulsogen TS 200 n) 0.20% by weight of Agrhopol 23 o) Water to 100% The present invention provides a composition comprising: a) 34.29% by weight of Bordeaux Mixture b) 2.78% by weight of Picoxystrobin c) 5.00% by weight of Propylene Glycol d) 1.00% by weight of Metasperse 550 S e) 2.80% by weight of Borresperse CA f) 2.00% by weight of Geropon T-77 g) 2.00% by weight of Atlox 4894 h) 0.10% by weight of SAG 1572 i) 0.05% by weight of Proxel GXL j) 36.86% by weight of water k) 3.06% by weight of Prothioconazole l) 3.06% by weight of Armid DM 10 m) 1.50% by weight of Emulsogen TS 200 n) 0.50% by weight of Triethanolamine o) 5.00% by weight of Rhodopol 23(2%)

The present invention provides a composition comprising: a) 34.29% by weight of Bordeaux Mixture b) 2.78% by weight of Picoxystrobin c) 5.00% by weight of Propylene Glycol d) 1.00% by weight of Metasperse 550 S e) 2.80% by weight of Borresperse CA f) 2.00% by weight of Geropon T-77 g) 2.00% by weight of Atlox 4894 h) 0.10% by weight of SAG 1572 i) 0.05% by weight of Proxel GXL j) 41.66% by weight of water k) 0.35% by weight of Thiourea l) 3.06% by weight of Prothioconazole m) 3.06% by weight of Armid DM 10 n) 1.50% by weight of Emulsogen TS 200 o) 0.25% by weight of Tri ethanol amine p) 0.095% by weight of Rhodopol 23

The present invention provides a composition comprising: a) 35.49% by weight of Bordeaux mixture b) 38.62% by weight of DM water c) 2.80% by weight of Picoxystrobin d) 3.16% by weight of Prothioconazole e) 3.20% by weight of Rhodiasolv Adma 10 f) 2% by weight of Geropon T-77 g) 2% by weight of Soprophor BSU h) 1.5% by weight of Water i) 1% by weight of Atlox Metasperse 500L j) 1.00% by weight of Atlas G5002L k) 0.1% by weight of SAG 1572 l) 9% by weight of Glycerol m) 0.02% by weight of Proxel GXL n) 0.1% by weight of Rhodopol 23

The present invention provides a composition comprising: a) 35.49% by weight of Bordeaux mixture b) 39.72% by weight of DM water c) 2.80% by weight of Picoxystrobin d) 3.16% by weight of Prothioconazole e) 3.50% by weight of Rhodiasolv Adma 10 f) 2% by weight of Geropon T-77 g) 1% by weight of Soprophor BSU h) 1% by weight of Atlox Metasperse 500L i) 1.00% by weight of Atlas G5002L j) 0.1% by weight of SAG 1572 k) 10% by weight of Glycerol l) 0.02% by weight of Proxel GXL m) 0.2% by weight of Rhodopol 23 n) 0.4% by weight of Thiourea

The present invention provides a composition comprising: a) 35.49% by weight of Bordeaux mixture b) 2.80% by weight of Borresperse CA c) 37.62% by weight of DM water d) 2.80% by weight of Picoxystrobin e) 3.16% by weight of Prothioconazole f) 3.50% by weight of Rhodiasolv Adma 10 g) 1% by weight of Geropon T-77 h) 1 % by weight of Soprophor BSU i) 1% by weight of Atlox Metasperse 500L j) 1.00% by weight of Atlas G5002L k) 0.1% by weight of SAG 1572 l) 10% by weight of Glycerol m) 0.02% by weight of Proxel GXL n) 0.1% by weight of Rhodopol 23 o) 0.4% by weight of Thiourea

The present invention provides a composition comprising: a) 30.08% by weight of Bordeaux mixture tech b) 2.71% by weight of Picoxystrobin tech c) 3.1 % by weight of Prothioconazole d) 0.2% by weight of AG-RH 23 e) 1% by weight of ATLAS G-5002L-LQ-(CQ) f) 1% by weight of Atlox Metasperse 500L-LQ-RB g) 2% by weight of GEROPON T 77 h) 10% by weight of Glycerine i) 0.02% by weight of Proxel GXL j) 3.5% by weight of RHODIASOLV ADMA 10 k) 0.1% by weight of SAG 1572 l) 1% by weight of Soprophor BSU m) 0.4% by weight of Thiourea n) 2.8% by weight of Borresperse CA o) Water up to 100%

The present invention provides a composition comprising: a) 35.49% by weight of Bordeaux Mix(27.22@9.66) . b) 2.80% by weight of Picoxystrobin(97@2.71) c) 10.00% by weight of Glycerol d) 2.00% by weight of Geropon T77 e) 1.00% by weight of Metasperse 500L f) 1.00% by weight of Atlas G5002L g) 0.10% by weight of SAG 1572 h) 0.02% by weight of Proxel GXL i) 34.93% by weight of DM water j) 3.16% by weight of Prothioconazole(98@3.0) k) 3.50% by weight of Armid DM 10 l) 1.00% by weight of Soprophor BSU m) 5.00% by weight of Rhodopol 23(2%)

Fungicide (I)

In some embodiments, the azole fungicide may include but is not limited to azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole and prothioconazole, mefentrifluconazole.

In some embodiments, the azole fungicide is tebuconazole.

In some embodiments, the azole fungicide is prothioconazole.

In some embodiments, the azole fungicide is cyproconazole.

In some embodiments, the azole fungicide is difenoconazole.

In some embodiments, the additional fungicide is selected from the group consisting of strobilurin fungicides, benzamide fungicide, morpholines, Qil fungicide, SDHI and any combination thereof.

In some embodiments, the strobilurin fungicide may include but is not limited to azoxystrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, trifloxystrobin, dimoxystrobin, fenaminstrobin, metominostrobin, orysastrobin, metyltetraprole and fluoxastrobin.

In some embodiments, the strobilurin fungicide is selected from group consisting of picoxystrobin, trifloxystrobin, azoxystrobin, pyraclostrobin, metominostrobin, metyltetraprole, mandestrobin and any combination thereof.

In some embodiments, the strobilurin fungicide is picoxystrobin.

In some embodiments, the strobilurin fungicide is azoxystrobin.

In some embodiments, the SDHI may include but is not limited to penthiopyrad, boscalid, flutolanil, fluxapyroxad, inpyrfluxam, fluopyram, fluindapyr, benzodiflupyr, bixafen and pydiflumetofen.

In some embodiments, the SDHI fungicide is selected from group consisting of bixafen, fluxapyroxad, fluindapyr; inpyrfluxam, benzodiflupyr, pydiflumetofen and any combination thereof.

In some embodiments, the SDHI fungicide is fluxapyroxad.

In some embodiments, the Qil fungicide may include but is not limited to cyazofamid, amisulbrom and fenpicoxamid.

In some embodiments, the Qil fungicide is fenpicoxamide.

In some embodiments, morpholines may include but is not limited to aldimorph, fenpropimorph, ridemorph, dodemorph, spiroxamine, piperalin, fenpropidin.

In some embodiments, the benzamide fungicide is fluopicolide.

Copper-Based Fungicides

In some embodiments, the copper-based fungicide is selected from group consisting of cupric acetate, cupric chloride, cupric chlorate, cupric formate, cupric hexafluorosilicate, cupric nitrate, cupric chromate, copper sulfate pentahydrate, Bordeaux mixture, copper hydroxide, tribasic copper sulfate such as cupric sulfate, tricupric hydroxide, hemihydrate, and any combination thereof. In some embodiment, the copper-based fungicide is selected from group consisting of copper oxychloride, copper hydroxide, copper sulfate, cupric acetate, cupric chloride, cupric chlorate, cupric formate, cupric hexafluorosilicate, cupric nitrate, cupric chromate, copper sulfate pentahydrate, Bordeaux mixture and/or any combination thereof.

In some embodiment, the copper-based fungicide is copper oxychloride.

In some embodiment, the copper-based fungicide is copper oxide.

In some embodiment, the copper-based fungicide is copper sulphate.

In some embodiment, the copper-based fungicide is Bordeaux mixture.

In some embodiments, the copper-based fungicide is CuSO4°Cu(OH)2°3CaSO4 (equivalent to 66 g/L of Copper) (Bordeaux mixture)

Taurate-Based and Isethionate-Based Surfactants

In some embodiments, the surfactant is a taurate-based surfactant.

In some embodiments, the taurate-based surfactant is Geropon T 77.

In some embodiments, the concentration of Geropon T 77 in the composition is from 1 to 2% w/w based on the total weight of the composition.

In some embodiments, the surfactant is an isethionate-based surfactant

In some embodiments, the isethionate-based surfactant is Hostapon SCI - sodium cocoyl isethionate.

In some embodiments, the concentration of the surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof in the composition is from 1 to 2% w/w based on the total weight of the composition.

Processes of Preparation The present invention provides a process for preparing the composition described herein, wherein the process comprises the following steps: (a) preparing an aqueous composition (composition 1) of the copper-based fungicide and optional additional fungicide, (b) preparing an emulsifiable concentrate comprising the fungicide (I) (composition 2), and (c) mixing composition 1 from step (a) and composition 2 from step (b) in the presence of at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof.

In some embodiments, the surfactant is a taurate-based surfactant.

In some embodiments, the taurate-based surfactant is part of composition 1.

In some embodiments, the taurate-based surfactant is added to water prior to adding to composition 1.

In some embodiments, composition 1 is a suspension concentrate composition.

In some embodiments, the taurate-based surfactant is part of composition 2.

In some embodiments, the emulsifiable concentrate (b) is free of thiourea and of ethylene diamine.

In some embodiments, the emulsifiable concentrate (b) is free of thiourea, hexamethylene tetra amine, sodium thiosulfate, ethylene diamine and any combination thereof.

In some embodiments, the aqueous composition comprises an anionic polymeric surfactant, preferably a sulfonate anionic polymeric surfactant, preferably a lignosulfonate.

In some embodiments, the invention refers to a composition comprising (1) a copperbased fungicide, (2) water, and (3) an anionic polymeric surfactant, wherein the composition is adapted for the preparation of a suspoemulsion following the addition of a water immiscible composition.

In some embodiments, the composition is free of thiourea, hexamethylene tetra amine, sodium thiosulfate, ethylene diamine and any combination thereof In some embodiments, the anionic polymeric surfactant is a sulfonate anionic polymeric surfactant, preferably a lignosulfonate.

In some embodiments, the adaptation comprises at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein the copper-based fungicide is suspended in the water.

In some embodiments, the invention refers to an azole fungicidal composition adapted for combination with copper fungicides, wherein the adaptation comprises the inclusion of a taurate-based surfactants in the azole composition.

In some embodiments, the taurate-based surfactant is methyl oleoyl taurate.

In some embodiments, the composition adapted for the preparation of a suspoemulsion is free from thiourea, hexamethylene tetra amine, sodium thiosulfate, ethylene diamine and any combination thereof.

In some embodiments, the composition adapted for the preparation of a suspoemulsion is free from ethylene diamine and thiourea.

In some embodiments, the invention refers to a water-based composition for preparing a suspoemulsion upon addition of a water immiscible composition, the water-based composition comprising (1) a copper-based fungicide, (2) water, and (3) an anionic polymeric surfactant.

In some embodiments, the water-based composition for preparing a suspoemulsion is free from ethylene diamine and thiourea.

In some embodiments, the water-based composition for preparing a suspoemulsion is free from thiourea, hexamethylene tetra amine, sodium thiosulfate, ethylene diamine and any combination thereof.

In some embodiments, the invention refers to the use of taurate surfactants as compatibilizing agents for combining azole and copper fungicidal compositions.

In some embodiments, the invention refers to the use of a taurate-based surfactant, isethionate-based surfactants, or/and any combination thereof for stabilizing a composition comprising (1) a copper-based fungicide, (2) water, and (3) a water immiscible carrier, wherein the copper-based fungicide is suspended in the water.

In some embodiments, the invention refers to a method for reducing the viscosity and/or the phase separation of a composition comprising (I) a copper-based fungicide, (2) water, and (3) a water immiscible carrier, wherein the method comprises providing a taurate-based surfactant, an isethionate-based surfactant and any combination thereof

In some embodiments, the invention refers to a method for preparing a suspoemulsion comprising a copper-based fungicide, wherein the method comprises: providing (1) a copper-based fungicide, (2) water, (3) a water immiscible carrier, and (4) a taurate- based surfactant, an isethionate-based surfactant and any combination thereof.

In some embodiments, the invention refers to a method for preparing a suspoemulsion comprising a copper-based fungicide with reduced viscosity and/or reduced phase separation, wherein the method comprises: providing (1) a copper-based fungicide, (2) water, (3) a water immiscible carrier, and (4) a taurate-based surfactant, an isethionate- based surfactant and any combination thereof.

In some embodiments, the invention refers to the use of a taurate-based surfactant, isethionate-based surfactants, and any combination thereof for reducing the viscosity of a composition comprising (1) a copper-based fungicide, (2) water, and (3) a water immiscible carrier, wherein the copper-based fungicide is suspended in the water.

In some embodiments, the invention refers to the use of a taurate-based surfactant, isethionate-based surfactants, and any combination thereof for stabilizing and/or for reducing the viscosity of a composition comprising (1) a copper-based fungicide, (2) water, and (3) a water immiscible carrier, wherein the copper-based fungicide is suspended in the water, and wherein the composition further comprises an anionic polymeric surfactant, preferably a sulfonate anionic polymeric surfactant, preferably a lignosulfonate.

In some embodiments, the invention refers to the use of a taurate-based surfactant, isethionate-based surfactants, and any combination thereof for stabilizing and/or for reducing the viscosity of a composition comprising (1) a copper-based fungicide, (2) water, and (3) a water immiscible carrier, wherein the copper-based fungicide is suspended in the water, and wherein one or more additional fungicide is dissolved in the water immiscible carrier.

In some embodiments, the invention refers to the use of a taurate-based surfactant, isethionate-based surfactant, and any combination thereof for preparing an SE composition comprising (i) an aqueous phase comprising a copper fungicide, and (ii) a non-aqueous phase comprising at least one additional fungicide.

Methods of Use

Controlling refers to preventing, curative and persistence.

The present invention also provides a method for controlling plant disease caused by pathogen comprising applying an effective amount of any one of the herein described combination and/or composition and/or suspension to a plant, a locus thereof, propagation material thereof, or an area infested with the unwanted insect so as to thereby control the plant disease caused by pathogen.

In some embodiments, the locus of the plant is the vicinity of the plant.

In some embodiments, the area infested with the pathogen.

In some embodiments, biological activity refers to persistence efficacy.

The present invention also provides use of the combination and/or composition, described herein for treating a plant, or a part of a plant, against a pathogen.

The present invention also provides use of the combination, and/or composition described herein for reducing the rate of application required for treating a plant, or a part of a plant, against a pathogen. The present invention provides a method of treating a plant, or a part of a plant, against a pathogen, comprising contacting the plant, or part of the plant, with any one or any combination and/or composition described herein.

In some embodiments, treating comprises preventing, reducing and/or eliminating the presence of the pathogen on the plant, or part of the plant. In some embodiments, treating comprises controlling diseases caused by the pathogen.

In some embodiments, the method of treating the plant, or the part of a plant against a pathogen comprises protecting the plant, or a part of a plant, against the pathogen, comprising contacting the plant, or part of the plant, with any one of any combination, and/or composition, described herein.

In some embodiments, the method of treating the plant, or the part of a plant against a pathogen comprises preventing, reducing and/or eliminating the presence of the pathogen on the plant, or part of the plant, comprising contacting the plant, or part of the plant, with any one of any combination and/or composition described herein.

In some embodiment, the method of treating the plant, or the part of a plant against a pathogen comprises controlling diseases caused by phytopathogenic fungi in plants or on propagation material thereof, which method comprises contacting the plants, or propagation material thereof, with any one of any combination and/or composition described herein.

In some embodiments, the method of treating the plant, or the part of a plant against a pathogen comprises improving pest control comprising applying any one of any combination and/or composition described herein to a plant/or soil.

In some embodiments, the pathogen is phytopathogenic fungi and the method comprises controlling diseases caused by phytopathogenic fungi in the plant or on propagation material thereof comprising contacting the plant, or propagation material thereof, with any one of any combination and/or composition described herein.

The invention further provides a method of protecting a plant or plant part against a pathogen, comprising contacting said plant or said plant part with a diluted aqueous composition according to this invention. The invention further provides a method of preventing, reducing and/or eliminating the presence of a pathogen on a plant, or a part of a plant, comprising contacting said plant, or part of said plant, with an aqueous composition according to this invention.

In some embodiments, the method of treating the plant, or the part of a plant against a pathogen comprises preventing, reducing and/or eliminating the presence of the pathogen on the plant, or part of the plant, comprising contacting the plant, or part of the plant, with any one of any combination and/or composition, described herein

The invention further provides a method of controlling diseases caused by phytopathogenic fungi in plants or on propagation material thereof, which method comprises contacting the plants, or propagation material thereof, with a composition according to the invention, including an aqueous diluted composition.

Rate of application may refer to an application rate of 22 g a.i./ha additional fungicide(a.i.)/ha to 2.2 g a.i./ha, 0.22g a.i./ha, 0.022g a.i./ha, 0.0022g a.i./ha, 750 g a.i./ha, 450g a.i./ha, 375, 150 g a.i./ha, 15 g a.i./ha, 2.9gr a.i./ lit, 11.6gr a.i./lit, preferably 0.0022 g a.i./ha to 0.75 kg a.i./ha. Rate of application may refer to an application rate of 22 g a.i./ha to 2.2 g a.i./ha of additional fungicide. In some embodiments, the copper-based fungicide is applied at a rate of 750 g a.i./ha, 605 mg a.i./ha, or 500 mg a.i./ha.

In some embodiments, the combination and/or composition is applied at an amount of 0.01-5 g/ha of the copper-based fungicide. In some embodiments, the combination and/or composition, is applied at an amount of 0.01-3 g/ha of the copper-based fungicide. In some embodiments, the combination and/or composition, is applied at an amount of 0.01-2 g/ha of the copper-based fungicide. In some embodiments, the combination and/or composition, is applied at an amount of 0.01-1 g/ha of the copperbased fungicide.

In some embodiments, the combination and/or composition, is applied at an amount of 0.018 g/ha of copper-based fungicide. In some embodiments, the combination and/or composition, is applied at an amount of 0.97 g/ha of copper-based fungicide. In some embodiments, the combination and/or composition, is applied at an amount of 0.39 g/ha of copper-based fungicide. In some embodiments, the combination and/or composition, is applied at an amount of 1.56 g/ha of copper-based fungicide. In some embodiments, the combination and/or composition, is applied at an amount between O.OOlg/ha to 1000 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount between lOOg/hato 1000 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount between 100 g/ha to 500 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount between 500 g/ha to 1000 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount between O.OOlg/ha to 100 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount between O.OOlg/ha to 50 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount between O.OOlg/ha to 25 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount between O.OOlg/ha to 10 g/ha of copper metal.

In some embodiments, the combination and/or composition, is applied at an amount of about 0.0022 g/ha, 0.022 g/ha, 0.22 g/ha, 2.2 g/ha or 22 g/ha of copper metal.

In some embodiments, the combination and/or composition, is applied at an amount of about 0.0075 g/ha, 0.075 g/ha, 0.75 g/ha, 7.5 g/ha or 75 g/ha of copper metal.

In some embodiments, the combination and/or composition, is applied at an amount of about 0.0052 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount of about 0.001 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount of about 0.059 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount of about 0.0095 g/ha of copper metal.

In some embodiments, the combination and/or composition, is applied at an amount of about 15 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount of about 150 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount of about 375 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount of about 450 g/ha of copper metal. In some embodiments, the combination and/or composition, is applied at an amount of about 750 g/ha of copper metal. A composition and/or combination according to the invention is suitable for the control of pests that are encountered in horticulture, agriculture, and forestry. The compositions are active against normally sensitive and resistant pest species and during all or individual stages of development. Prior to use, a composition comprising a copperbased fungicide and azole fungicide according to the invention is preferably dissolved or dispersed in water, or diluted with water, to provide an aqueous composition comprising between 0.001 and 10 w/v% of the copper-based fungicide. If required, an agriculturally acceptable carrier such as a sticking compound (I) is added to the diluted aqueous composition.

A composition according to the invention is preferably diluted 2-5000 times, preferably about 200 times, with an aqueous solvent, preferably water, to contain between 0.0001 and 10 % (w/v) of the copper-based fungicide, prior to contacting a plant, plant part or soil with the composition.

To control agricultural pests, the invention provides a use of a composition comprising a copper-based fungicide and azole fungicide according to the invention for the protection of a plant, or a part of a plant, against a pathogen. In order to achieve this effect, said plant or plant part, or a soil, is contacted with said composition, including a diluted aqueous composition.

Said composition is used, for example, to control soybean rust, powdery mildew and downy mildew infections on food/feed crops, including tree fruits, vegetable crops, field crops, grapes, ornamental plants, and sod farms. Further use, for example, is to control scab, including common scab, apple scab and black scab on potatoes, pear scab, and powdery scab, brown rot of peaches, currant and gooseberry leaf spot, peanut leafspot, and mildew on roses. Other uses include protection of greenhouse grown flowers and ornamentals, home vegetable gardens and residential turf. In addition, said composition, including a diluted aqueous composition, may be contacted with isolated fruits, nuts, vegetables, and/or flowers.

For said use and said methods, the composition, including a diluted aqueous composition, is preferably sprayed over a plant, or part thereof. Spraying applications using automatic systems are known to reduce labor costs and are cost-effective. Methods and equipment well-known to a person skilled in the art can be used for that purpose. The composition, including diluted aqueous composition, can be regularly sprayed, when the risk of infection is high. When the risk of infection is lower, spray intervals may be longer.

Other methods suitable for contacting plants or parts thereof with a composition of the invention are also a part of the present invention. These include, but are not limited to, dipping, watering, drenching, introduction into a dump tank, vaporizing, atomizing, fogging, fumigating, painting, brushing, misting, dusting, foaming, spreading-on, packaging and coating (e.g., by means of wax or electrostatically). In addition, the composition, including a diluted aqueous composition, may be injected into the soil.

For example, a plant of part thereof may be coated with a diluted aqueous composition comprising a copper-based fungicide according to the invention by submerging the plant or part thereof in a diluted aqueous composition to protect the plant of part thereof against a pathogen and/or to prevent, reduce and/or eliminate the presence of a pathogen on a plant, or a part of a plant. A preferred part of a plant that is coated with a composition according to the invention, or with a dilution thereof, is seed. A further preferred part of a plant that is coated with a composition according to the invention, or with a dilution thereof, is leaf. A further preferred part of a plant that is coated with a composition according to the invention, or with a dilution thereof, is a fruit, preferably a post-harvest fruit such as, for example, a citrus fruit such as orange, mandarin and lime, a pome fruit such as apple and pear, a stone fruit such as almond, apricot, cherry, damson, nectarine, tomato, watermelon, a tropical fruit such as banana, mango, lychee and tangerine. A preferred fruit is a citrus fruit, such as orange and/or a tropical fruit such as banana.

In addition, when lists are provided, the list is to be considered as a disclosure of each member in the list, independently.

This invention will be better understood by reference to the Experimental Details which follow, but those skilled in the art will readily appreciate that the specific experiments detailed are only illustrative of the invention as described more fully in the claims which follow thereafter.

The invention is illustrated by the following examples without limiting it thereby. EXPERIMENTAL SECTION

Example 1 - Suspoemulsion (SE) composition

Table 1. SE composition of Bordeaux mixture + Prothioconazole + Picoxystrobin

Example 2 - Suspoemulsion (SE) composition

Table 2. SE composition of Bordeaux mixture + Prothioconazole + Picoxystrobin

Preparation Process of SE formulations: Procedure-01 (Example 1, 2)

SC preparation :

The required quantity of DM water was taken in the beaker followed by addition of proxel GXL, propylene glycol, Atlox 4894, Borosperse CA, Geropon T77, Metasperse 500L, and l/3rd part of SAG 1572 with continuous stirring at 350-500 rpm using pitched four blade impeller.

Later, Bordeaux mixture was added slowly and mixed well with stirring at 350-500 rpm using pitched four blade impeller until homogeneous slurry was obtained.

Then, picoxystrobin technical was added slowly and mixed well with stirring at 3 SO- SOO rpm using pitched four blade impeller until homogeneous slurry was obtained.

The above premix was grinded in bead mill to attain particle size D90 <4 micron.

The grinded premix was further stirred at 350-500 rpm using pitched four blade impeller for another 30 minutes after milling. Compound (I) (ethylene diamine, thiourea or mixture of sodium thiosulphate and thio urea) was dissolved in water and added to the above SC part and mixed well for 5 minutes.

Preparing the emulsifiable concentrate (EC) comprising azole fungicide:

The required quantity of solvent (ADMA10) was taken in a beaker and prothioconazole technical was added and dissolved.

The emulsifier Emulsogen TS200 was added to the above solution and stirred well at 350-500 rpm using pitched four blade impeller until clear solution is obtained.

Preparation of suspoemulsion - SE:

EC part was added slowly for 15 -20 min under stirring using pitched four blade impeller at 800-1000 rpm to the SC part prepared earlier.

Increase in viscosity was observed during mixing due to emulsification of EC part with aqueous part of SC.

Stirring was continued for about 30 min and the remaining quantity of SAG 1572 was added. The suspoemulsion obtained was mixed for another 15 minutes.

The required quantity of 4% solution of Aghropol 23 was added and stirred well to obtain final suspoemulsion formulation.

Example 3 - Suspoemulsion (SE) composition

Table 3. A composition comprising copper-based fungicide C11SO4 Bordeaux mixture 125g/L+ Picoxystrobin 35 g/L + Prothioconazole 40 g/L, and polyelectrolyte, wherein the polyelectrolyte comprises only Calcium lignosulfonate polyanion.

Example 4 - Suspoemulsion (SE) composition

Table 4.

Preparation Process of SE formulations: Procedure-02 (Example 3, 4)

SC preparation :

The required quantity of DM water was taken in the beaker followed by addition of proxel GXL, propylene glycol, Atlox 4894, Borosperse CA, Geropon T77, Metasperse 550S, and l/3rd part of SAG 1572 with continuous stirring at 350- 500rpm using pitched four blade impeller.

Then, Bordeaux mixture was added slowly and mixed well with stirring at 350-500 rpm using pitched four blade impeller until homogeneous slurry was obtained.

The grinded premix was further stirred at 350-500 rpm using pitched four blade impeller for another 30 minutes after milling.

EC preparation:

The required quantity of solvent (Armid DM10) was taken in a beaker and Prothioconazole technical was added and dissolved.

Preparation of SE:

EC part was added slowly for 15 -20 min under stirring using pitched four blade impeller at 800-1000 rpm to the SC part prepared earlier. Increase in viscosity was observed during mixing due to emulsification of EC part with aqueous part of SC.

The pH of the above mixture was adjusted to be around 6-7 using Triethanol amine.

The required quantity of 2% or 4% solution of Aghropol 23/Rhodopol 23 was added with stirring at 350-500 rpm using pitched four blade impeller to get final viscosity about 1200-1400 cPs when measured with Spindle 62 at 12 RPM.

Example 5 - Suspoemulsion (SE) composition

Table 5.

Example 6 - Suspoemulsion (SE) composition Table 6.

Example 7 - Suspoemulsion (SE) composition

Table 7.

Example 8 - Suspoemulsion (SE) composition

Table 8. DT-CE-CPP-200-47T

Preparation Process of SE formulations: Procedure-03 (Examples 5-8)

PART (A) SC slurry/Premix preparation:

The SC portion premix was by prepared by adding Glycerol, defoamer SAG 1572, Atlas G5002L, Atlox Metasperse 500L, partial amount of water and stirred well. Geropon T- 77, calcium lignosulphonate (if required) were added and continued stirring to avoid any lump formation. Bordeaux mixture was added to slowly, followed by picoxystrobin. This slurry was mixed and stirred for 30 minutes and milled further in the bead mill at temperature less than 25 C to obtain particle size less than 7 micron.

PART (B) EW preparation:

Prothioconazole Tech was added into required quantity of solvent Adma 10 followed by addition of emulsifier Soprophor BSU to obtain clear EC solution. This EC was further mixed slowly into water containing thiourea and stirred well to obtain white milky homogeneous EW.

PART (C) Suspoemulsion preparation: The EW prepared in previous step was added to the slurry/premix very slowly to obtain mixture which changes from Bluish green-> Gray-> Bluish green on stirring for 30-45 minutes. This was further homogenized at temperature less than 30°C to obtain flowable mixture and required quantity of 2% aqueous rheology modifier, xanthan gum was added and stirred for 1 hour to obtain final suspoemulsion formulation.

The suspoemulsion compositions of the present invention have less than 5% of phase separation during storage (at room temperature for two weeks or at 54°C for two week) based on visual observation.

In contrast, the following compositions not containing taurate or isethionate surfactant were found unstable:

Unstable formulation compositions (Table: 09-13)

Table: 9 (Observation: Semisolid batch during milling and after rheology modifier addition)

Table: 10 (Observation: Batch turned semisolid after EC addition to SC portion.)

Table: 11 (Observation: Batch turned semisolid after EC addition to SC portion.)

Table: 12 (Observation: 10% brown color layer separation in AHS 54°C, 14 days)

Table: 13 (Observation: semisolid after EC addition to SC portion.)

Example 9 - Comparison of the viscosity and phase separation of compositions of the invention versus composition not comprising taurate and/or isethionate surfactants.

Different compositions were prepared using different surfactant and their properties were compared. The compositions were prepared according to table 14, and the results are reported in Table 15.

Table 14:

Table 15:

The composition of the invention presents less phase separation and a lower viscosity compared to the other compositions.

Claims

1. A composition comprising (1) a copper-based fungicide, (2) water, (3) a water immiscible carrier and (4) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein the copper-based fungicide is suspended in the water.

2. The composition of claim 1, wherein the composition comprises at least one additional fungicide (I).

3. The composition of claim 2, wherein the fungicide (I) is selected from the group consisting of strobilurin fungicides, azole fungicides, benzamide fungicides, morpholines, Qil fungicides, SDHI and any combination thereof.

4. The composition of claim 4, wherein the copper-based fungicide is suspended in the water and at least one fungicide (I) is dissolved in the water immiscible carrier.

5. The composition of any one of claims 1-4 wherein the composition is a suspoemulsion (SE).

6. The composition of any one of claims 1-5, wherein the copper-based fungicide is selected from the group consisting of Bordeaux mixture, copper oxychloride, copper oxide, copper sulfate and any combination thereof.

7. A composition comprising (1) a copper-based fungicide selected from the group consisting of Bordeaux mixture, copper oxychloride, copper oxide, copper sulphate and any combination thereof, (2) at least one fungicide (I) selected from the group consisting of strobilurin fungicides, azole fungicides, benzamide fungicides, morpholines, Qil fungicides, SDHI and any combination thereof, (3) water, (4) a water immiscible carrier, and (5) at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein the copper-based fungicide is suspended in the water and at least one fungicide (I) is dissolved in the water immiscible carrier. The composition of any one of claims 2-7, wherein the composition comprises two or more fungicides (I). The composition of claim 8, wherein: a. at least one fungicide (I) is dissolved in the water immiscible carrier and at least one fungicide (I) is suspended in water, or b. at least two fungicides (I) are dissolved in the water immiscible carrier. The composition of any one of claims 1-9, wherein the taurate-based surfactant is methyl oleoyl taurate. The composition of claim 10, wherein the methyl oleoyl taurate is Geropon T- 77. The composition of any one of claims 1-9, wherein the isethionate-based surfactant is Hostapon SCI - sodium cocoyl isethionate. The composition of any one of claims 1-11, wherein the composition is other than an SE composition comprising: a. 34.29 % by weight of Bordeaux Mixture b. 2.78% by weight of Picoxystrobin c. 5.0% by weight of propane- 1,2-diol, d. 1.0% by weight of Metasperse 550 S, e. 2.8% by weight of Borresperse CA f. 2% by weight of Geropon® T-77, g. 2.0% by weight of Atlox 4894 h. 0.1 % by weight of SAG 1572, i. 0.05% by weight of Proxel GXL, j. 36.86% by weight of DM water, k. 3.06% by weight of prothioconazole and l. 3.06% by weight of Armid DM 10, or a. 34.29% w/w of Bordeaux mix (9.4 at 27.22), b. 2.78% w/w of picoxystrobin (2.7 at 97), c. 5% w/w of propylene glycol, d. 1% w/w of Metasperse 550 S, e. 2.8% w/w of Borresperse CA, f. 2% w/w of Geropon T-77, g. 2% w/w of Atlox 4894, h. 0.1% w/w of SAG 1572, i. 0.05% w/w of Proxel GXL, j. 36.86% w/w of DM water, k. 3.06% w/w of prothioconazole, l. 3.06% w/w of Armid DM 10, m. 1.5% w/w of Emulsogen TS 200, n. 0.5% w/w of TEA, and o. 5% w/w of Rhodopol 23 (2%). The composition of claim 13, wherein the copper-based fungicide is Bordeaux mixture, and the fungicides (I) are prothioconazole and picoxystrobin. The composition of any one of claims 2-12, wherein the copper-based fungicide is Bordeaux mixture, and the fungicides (I) are prothioconazole and azoxystrobin. The composition of any one of claims 2-12, wherein the copper-based fungicide is Bordeaux mixture and the fungicides (I) are tebuconazole and picoxystrobin. The composition of any one of claims 2-12, wherein the copper-based fungicide is Bordeaux mixture and the fungicides (I) are tebuconazole and azoxystrobin. The composition of any one of claims 2-12, wherein the copper-based fungicide is Bordeaux mixture and the fungicides (I) are prothioconazole and fluxapyroxad. The composition of any one of claims 2-12, wherein the copper-based fungicide is Bordeaux mixture and the fungicides (I) are tebuconazole and azoxystrobin. The composition of any one of claims 2-12, wherein the copper-based fungicide is copper oxychloride and the fungicides (I) are prothioconazole and picoxystrobin. The composition of any one of claims 2-12, wherein the copper-based fungicide is copper oxychloride and the fungicides (I) are prothioconazole and azoxystrobin. The composition of any one of claims 2-12, wherein the copper-based fungicide is copper oxychloride mixture and the fungicides (I) are tebuconazole and picoxystrobin. The composition of any one of claims 2-12, wherein the copper-based fungicide is copper oxychloride and the fungicides (I) are tebuconazole and azoxystrobin. The composition of any one of claims 2-12, wherein the copper-based fungicide is copper oxychloride and the fungicides (I) are prothioconazole and fluxapyroxad. The composition of any one of claims 2-12, wherein the copper-based fungicide is copper oxychloride and the fungicides (I) are tebuconazole and azoxystrobin. A diluted composition prepared from the composition of any one of claims 1- 25. A composition of any one of claims 1-26 wherein the composition exhibits less than 5% phase separation after two weeks of storage. A composition of any one of claims 1-26 wherein the composition has a viscosity in the range of 700-2000 cPs. A composition of any one of claims 1-26 wherein the composition has viscosity in the range of 700-1500 cPs. A process for preparing the composition of any one of claims 1-26, wherein the process comprises the following steps: (a) preparing an aqueous composition (composition 1) of the copper-based fungicide and optional additional fungicide, (b) preparing an emulsifiable concentrate comprising the fungicide (I) (composition 2), and (c) mixing composition 1 from step (a) and composition 2 from step (b) in the presence of at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof. The process of claim 30 wherein the emulsifiable concentrate (b) is free of thiourea and ethylene diamine. The process of any one of claims 30-31 wherein the aqueous composition comprises an anionic polymeric surfactant, preferably a sulfonate anionic polymeric surfactant, preferably a lignosulfonate. Use of a taurate-based surfactants, isethionate-based surfactants, and any combination thereof for stabilizing a composition comprising (1) a copperbased fungicide, (2) water, and (3) a water immiscible carrier, wherein the copper-based fungicide is suspended in the water. Use of a taurate-based surfactants, isethionate-based surfactants, and any combination thereof for reducing the viscosity of a composition comprising (1) a copper-based fungicide, (2) water, and (3) a water immiscible carrier, wherein the copper-based fungicide is suspended in the water. The uses of any one of claims 33-34 wherein the composition further comprises an anionic polymeric surfactant, preferably a sulfonate anionic polymeric surfactant, preferably a lignosulfonate. The use of any one of claims 33-35 wherein one or more additional fungicide is dissolved in the water immiscible carrier. Use of a taurate-based surfactant, an isethionate-based surfactant, and any combination thereof for preparing a suspoemulsion composition comprising (i) an aqueous phase comprising a copper fungicide, and (ii) a non-aqueous phase comprising at least one additional fungicide. A method for controlling fungal disease comprising applying an effective amount of the composition of any one of claims 1 -29 to a plant, a locus thereof, propagation material thereof, or an area infested with the unwanted insects so as to thereby control the pathogen disease. A composition comprising (1) a copper-based fungicide, (2) water, and (3) an anionic polymeric surfactant, wherein the composition is adapted for the preparation of a suspoemulsion following the addition of a water immiscible composition. A water-based composition for preparing a suspoemulsion upon addition of a water immiscible composition, the water-based composition comprising (1) a copper-based fungicide, (2) water, and (3) an anionic polymeric surfactant. The composition of any one of claim 39-40 wherein the adaptation comprises at least one surfactant selected from the group consisting of taurate-based surfactants, isethionate-based surfactants and any combination thereof, wherein the copper-based fungicide is suspended in the water. The composition of any one of claims 39-41 wherein the anionic polymeric surfactant is a sulfonate anionic polymeric surfactant, preferably a lignosulfonate. The composition of any one of claims 39-42 wherein the surfactant is a taurate- based surfactant. The composition of claim 43 wherein the taurate-based surfactant is methyl oleoyl taurate. The composition of any one of claims 39-44 wherein the composition does not contain ethylene diamine and/or thiourea.