WO2023119322A1 - Molecular iodine and alcohol based formulation and its application in lavatory surface sanitization and disinfection - Google Patents

Abstract

Disclosed herein is a composition comprising free molecular Iodine (I₂) and alcohol which act as germicide, disinfectant, and sanitizing agent to kill a wide range of microorganisms including bacteria, fungi, and to some extent viruses, and also a process for its preparation. The composition further comprises glycerol and inert excipients. The composition can be utilized as a lavatory surface sanitizing agent/disinfecting agent or in products for instantaneous surface sanitization and disinfection.

Description

MOLECULAR IODINE AND ALCOHOL BASED FORMULATION AND ITS APPLICATION IN LAVATORY SURFACE SANITIZATION AND DISINFECTION

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of Indian Provisional Patent Application No. 202111059395 filed December 20, 2021, which is incorporated herein by reference for all purposes in its entirety.

FIELD OF THE INVENTION

The present invention relates to a composition comprising free molecular Iodine (I2) and alcohol which act as germicide, disinfectant, and sanitizing agent to kill a wide range of microorganisms including bacteria, fungi, and to some extent viruses, and also a process for its preparation. The composition further comprises glycerol and inert excipients. The composition can be utilized as a lavatory surface sanitizing agent/disinfecting agent or in products for instantaneous surface sanitization and disinfection.

BACKGROUND OF THE INVENTION

Current technology involves an aerosolized composition of a toilet seat sanitizer containing benzalkonium chloride, isopropyl alcohol (IPA), fragrance, solvents and propellant that protects from germs in public toilets and reduces the risk of contracting infections such as Urinary tract infections (UTIs).

Benzalkonium chloride used in the current technology has been known to have allergenic properties and is a well-known skin irritant. Isopropyl alcohol is readily absorbed through the skin and continuous exposure can cause redness, itching, drying, rash and cracking.

As such there is no product available in the market which provides instantaneous sanitization and disinfection upon application, is hypoallergenic upon accidental exposure, is non-irritant upon topical contact, is non-corrosive to the applied surface as well as does not leave any residue post application, together in a single product.

SUMMARY OF THE INVENTION

In one aspect, the present invention provides a composition which comprises molecular iodine (I2), a lower alcohol, and glycerol, wherein the composition is stable, wherein the composition delivers free molecular iodine ranging between 200 ppm and 300 ppm, and wherein the composition is formulated for application as a lavatory surface sanitizing agent and disinfectant.

In another aspect, the present invention provides a process for preparing a stable molecular iodine (I2) and a lower alcohol-based composition which delivers free molecular iodine in a range between 200 ppm and 300 ppm.

The process comprises the steps of:

(a) adding molecular iodine (I2) with a lower alcohol to obtain a solution; and

(b) adding glycerol to the solution obtained in step a); and

(c) optionally adding one or more fragrance substances.

DETAILED DESCRIPTION OF THE INVENTION

The term “molecular iodine” refers to diatomic iodine, which is represented by the chemical symbol I2. Molecular iodine is also referred to as “elemental iodine” when in the solid state.

In one aspect, the present invention provides a composition which comprises molecular iodine (I2), a lower alcohol, and glycerol, wherein the composition is stable, wherein the composition delivers free molecular iodine ranging between 200 ppm and 300 ppm, and wherein the composition is formulated for application as a lavatory surface sanitizing agent and disinfectant. In another embodiment of this aspect, the formulations can be in a spray form so as to cover up a greater surface area with uniform spread of the composition on the surfaces.

In another embodiment of this aspect, the lower alcohol can be ethanol, isopropanol or mixtures thereof. In a preferred embodiment of this aspect, the lower alcohol is ethanol.

In another embodiment of this aspect, the composition comprises:

(a) molecular iodine in a range between 200 ppm and 300 ppm;

(b) ethanol, isopropyl alcohol, or mixtures thereof in a range between 95% to 98% v/v of the total concentration of the composition;

(c) glycerol in a range between 2% and 5% v/v of the total concentration of the composition; and

(d) one or more fragrance substances in a range between 0.3% and 0.8% v/v of the total concentration of the composition.

In yet another embodiment of this aspect, the fragrance can be selected from aqua kiss, tempting, invincible, or a mixture thereof. In a preferred embodiment of this aspect, the fragrance is tempting.

In yet another embodiment of this aspect, the pharmaceutical and/or cosmeceutical composition act can actively alter the activity of the microorganisms found in restroom surfaces including but not limited to fecal bacteria, Influenza, Streptococcus, Escherichia coli, Methicillin-resistant Staphylococcus aureus, Salmonella, Shigella, norovirus, and others, thereby helping in an efficient sanitization and disinfection of the surfaces. Molecular iodine (I2), as the active ingredient with ethanol and glycerol as germicide and solvent respectively, acts as a broad- spectrum antimicrobial agent possessing antibacterial, antifungal and antiviral properties with an instantaneous effect. The composition can prove to be a highly effective way to sanitize and disinfect the surfaces in public restrooms such as in office settings, healthcare settings, etc. thereby helping to prevent the risk of and considerably reduce incidence of contracting infections such as urinary tract infections (UTIs). The composition in this invention can find its application in disinfecting the restroom surfaces routinely touched with hands such as wash basin, etc.

In yet another embodiment of this aspect, the composition is stable for at least 24 months at room temperature. In yet another preferred embodiment, the composition is stable for at least 24 months at room temperature when stored in a closed container at room temperature. In yet another preferred embodiment, the composition is stable for at least 180 days and was according to the requirements of the end product as a sanitizing agent or disinfecting agent or in products for instantaneous surface sanitization and disinfection. In yet another preferred embodiment, the composition is stable for at least 7 days and was according to the requirements of the end product as a sanitizing agent or disinfecting agent or in products for instantaneous surface sanitization and disinfection.

In another aspect, the present invention provides a process for preparing a stable molecular iodine (I2) and a lower alcohol-based composition which delivers free molecular iodine in a range between 200 ppm and 300 ppm which comprises the steps of:

(a) adding molecular iodine (I2) with a lower alcohol to obtain a solution; and

(b) adding glycerol to the solution obtained in step a); and

(c) optionally adding one or more fragrance substances.

In one embodiment of this aspect, the process is carried out at room temperature. In one embodiment of this aspect, the lower alcohol can be ethanol, isopropanol or mixtures thereof. In a preferred embodiment of this aspect, the lower alcohol is ethanol.

In another embodiment of this aspect, the step b) further comprises mixing thoroughly.

In yet another embodiment of this aspect, the fragrance can be selected from aqua kiss, tempting, invincible, or a mixture thereof. In a preferred embodiment of this aspect, the fragrance is tempting.

In yet another embodiment, the process comprises:

(a) adding molecular iodine (I2) in a range between 200 ppm and 300 ppm with ethanol in a range between 95% to 98% v/v of the total concentration of the composition to obtain a solution; and

(b) adding glycerol in a range between 2% and 5% v/v of the total concentration of the composition to the solution obtained in step a); and

(c) optionally adding tempting in a range between 0.3% and 0.8% v/v of the total concentration of the composition.

While the present invention has been described in terms of its specific aspect, certain modifications and equivalents will be apparent to those skilled in the art and are intended to be included within the scope of the present invention.

In the following section, the aspect is described by way of examples to illustrate the processes of the invention. However, these do not limit the scope of the present invention. Several variants of these examples would be evident to persons ordinarily skilled in the art. EXAMPLE

The base solution/concentrate of Iodine used in the below example was obtained as a stock solution with Iodine maintained at 1 mg/ml (w/v) concentration. (For a formulation to be prepared, the required amount of iodine was measured and added according to the final concentration required in the formulation being prepared).

A 100 ml formulation was prepared using the following ingredients (for example, to be used as a lavatory surface sanitizer and disinfection solution) with molecular iodine concentration maintained at about 250 ppm.

Iodine (0.25 ml) from the stock solution was added to ethanol (97.25 ml) to obtain a solution. To this solution, glycerol (2 ml) was added and mixed. Fragrance (tempting) (0.5 ml) was added to obtain the final product.

Three samples of the formulation were taken and observed for 0 day and 7 days to check for stability with Iodine, spray ability and colour change (if any).

The final solution was of the required viscosity which was in a sprayable form. The formulation was observed to be stable with respect to its colour, and stability at all the time intervals as mentioned above.

The foregoing description of the specific embodiments so fully reveals the general nature of the embodiments herein that others can, by applying current knowledge, readily modify and/or adapt for various applications such specific embodiments without departing from the generic concept, and, therefore, such adaptations and modifications should and are intended to be comprehended within the meaning and range of equivalents of the disclosed embodiments. It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the embodiments as described herein.

Throughout this specification the word “comprise”, or variations such as “comprises” or “comprising”, will be understood to imply the inclusion of a stated element, integer or step, or group of elements, integers or steps, but not the exclusion of any other element, integer or step, or group of elements, integers or steps.

The use of the expression “at least” or “at least one” suggests the use of one or more elements or ingredients or quantities, as the use may be in the embodiment of the disclosure to achieve one or more of the desired objects or results.

Any discussion of documents, acts, materials, devices, articles or the like that has been included in this specification is solely for the purpose of providing a context for the disclosure. It is not to be taken as an admission that any or all of these matters form a part of the prior art base or were common general knowledge in the field relevant to the disclosure as it existed anywhere before the priority date of this application.

The numerical values mentioned for the various physical parameters, dimensions or quantities are only approximations and it is envisaged that the values higher/lower than the numerical values assigned to the parameters, dimensions or quantities fall within the scope of the disclosure, unless there is a statement in the specification specific to the contrary.

While considerable emphasis has been placed herein on the components and component parts of the preferred embodiments, it will be appreciated that many embodiments can be made and that many changes can be made in the preferred embodiments without departing from the principles of the disclosure. These and other changes in the preferred embodiment as well as other embodiments of the disclosure will be apparent to those skilled in the art from the disclosure herein, whereby it is to be distinctly understood that the foregoing descriptive matter is to be interpreted merely as illustrative of the disclosure and not as a limitation.

Claims

CLAIMS I claim:

1. A composition which comprises molecular iodine (I2), a lower alcohol, and glycerol, wherein the composition is stable, wherein the composition delivers free molecular iodine ranging between 200 ppm and 300 ppm, and wherein the composition is formulated for application as a lavatory surface sanitizing agent and disinfectant.

2. The composition as claimed in claim 1, wherein the composition is in a sprayable form.

3. The composition as claimed in claim 1, wherein the lower alcohol is ethanol, isopropanol, or mixtures thereof.

4. The composition as claimed in claim 3, wherein the lower alcohol is ethanol.

5. The composition as claimed in claim 1, wherein the composition comprises:

(a) molecular iodine in a range between 200 ppm and 300 ppm;

(b) ethanol, isopropyl alcohol, or mixtures thereof in a range between 95% to 98% v/v of the total concentration of the composition;

(c) glycerol in a range between 2% and 5% v/v of the total concentration of the composition; and

(d) one or more fragrance substances in a range between 0.3% and 0.8% v/v of the total concentration of the composition.

6. The cosmeceutical composition as claimed in claim 5, wherein the fragrance is selected from aqua kiss, tempting, invincible, or a mixture thereof.

7. The cosmeceutical composition as claimed in claim 6, wherein the fragrance is tempting.

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8. The composition as claimed in claim 1, wherein the composition serves as an active sanitizer or disinfectant against fecal bacteria, Influenza, Streptococcus, Escherichia coli, Methicillin-resistant Staphylococcus aureus, Salmonella, Shigella, norovirus.

9. The composition as claimed in claim 1, wherein the composition is stable for at least 24 months at room temperature.

10. The composition as claimed in claim 1, wherein the composition is stable for at least 7 days at room temperature.

11. The composition as claimed in claim 1, wherein the lavatory surface includes public restrooms, office settings, and healthcare settings.

12. A process for preparing a stable molecular iodine (I2) and a lower alcohol-based composition which delivers free molecular iodine in a range between 200 ppm and 300 ppm which comprises the steps of:

(a) adding molecular iodine (I2) with a lower alcohol to obtain a solution; and

(b) adding glycerol to the solution obtained in step a); and

(c) optionally adding one or more fragrance substances.

13. The process as claimed in claim 12, wherein the process is carried out at room temperature.

14. The process as claimed in claim 12, wherein the alcohol is a lower alcohol selected form ethanol, isopropanol or mixtures thereof.

15. The process as claimed in claim 14, wherein the lower alcohol is ethanol.

16. The process as claimed in claim 12, wherein the fragrance is selected from aqua kiss, tempting, invincible, or a mixture thereof.

17. The process as claimed in claim 12, wherein the process comprises:

(a) adding molecular iodine (I2) in a range between 200 ppm and 300 ppm with ethanol in a range between 95% to 98% v/v of the total concentration of the composition to obtain a solution; and

(b) adding glycerol in a range between 2% and 5% v/v of the total concentration of the composition to the solution obtained in step a); and

(c) optionally adding tempting in a range between 0.3% and 0.8% v/v of the total concentration of the composition.

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