WO2023179305A1

WO2023179305A1 - Method and system for performing stroke rehabilitation analysis by using near-infrared brain function imaging device

Info

Publication number: WO2023179305A1
Application number: PCT/CN2023/078118
Authority: WO
Inventors: 汪待发; 邓皓; 梁航
Original assignee: 丹阳慧创医疗设备有限公司
Priority date: 2022-03-25
Filing date: 2023-02-24
Publication date: 2023-09-28
Also published as: CN114391815A

Abstract

A method and system for performing stroke rehabilitation analysis by using a near-infrared brain function imaging device. The near-infrared brain function imaging device (500) is provided with a head cap (501) for being worn on an object head (505), and the head cap (501) is provided with a plurality of probes (506) for transmitting and/or receiving near-infrared signals to collect near-infrared signals of a plurality of corresponding channels. The stroke rehabilitation analysis method comprises: in the case that an object performs groups of alternating tasks of upper limb movement and rest state, using the plurality of probes (506) to acquire a first blood oxygen concentration signal of each channel of the left side brain region at least corresponding to the upper limb movement, and a second blood oxygen concentration signal of each channel of the right side brain region at least corresponding to the upper limb movement; determining, according to the acquired first blood oxygen concentration signal and the acquired second blood oxygen concentration signal, an analysis result in the current stroke rehabilitation state of the object; and displaying the determined analysis result in the current stroke rehabilitation state of the object. The method is beneficial to eliminating interference and improving the analysis accuracy.

Description

Method and system for stroke rehabilitation analysis using near-infrared functional brain imaging device

Technical field

This application generally relates to the field of medical equipment, and specifically relates to methods and systems for stroke rehabilitation analysis using near-infrared functional brain imaging devices.

Background technique

Near-infrared spectrum functional brain imaging (fNIRS) is a new type of brain functional imaging technology. Utilizing multi-channel sensing composed of near-infrared light and a transmitting probe-receiving probe, based on the nerve-blood oxygen coupling mechanism, fNIRS can penetrate the skull, detect and image changes in brain activity activation with high time resolution, and effectively monitor brain function. Visualization and quantitative assessment. Currently, near-infrared spectrum functional brain imaging technology can be used to evaluate stroke recovery. However, the inventor found that it usually requires continuous collection of near-infrared signals from a large range of brain areas of subjects for more than ten minutes. The drift of signal strength and frequency band interference are relatively small. Seriously, although I tried to reduce noise interference, the effect was not good. In addition, in the existing technology, the near-infrared signal during the subject's rehabilitation training movement is used to perform stroke rehabilitation analysis, and the rehabilitation training movement task is maintained for ten or even dozens of minutes to perform stroke rehabilitation analysis. For some patients with severe stroke, It is said that it is difficult and patients' compliance is not high, which also seriously affects the accuracy of assessment.

Contents of the invention

In view of the above technical problems existing in the prior art, this application is proposed. The purpose of this application is to provide a method and system for stroke rehabilitation analysis using a near-infrared brain functional imaging device, which is especially suitable for patients with severe stroke and can complete analysis and evaluation in a short time to improve efficiency and reduce signal drift and frequency band interference. , to improve the accuracy of analysis results.

According to a first aspect of the present application, a method for performing stroke rehabilitation analysis using a near-infrared functional brain imaging device is provided. The near-infrared functional brain imaging device has a headgear for wearing on a subject's head, and the headgear is provided with a Multiple probes that transmit and/or receive near-infrared signals to collect near-infrared signals of multiple corresponding channels, and obtain blood oxygen concentration signals of multiple corresponding channels accordingly, the method includes: performing a group of In the case of an alternating task of upper limb movement and resting state, the plurality of probes are used to obtain the first blood oxygen concentration information of each channel of the left brain area corresponding to at least the upper limb movement. number, and at least the second blood oxygen concentration signal of each channel corresponding to the right brain area of the upper limb movement, wherein the number of groups of the alternating task, the duration of each group of upper limb movement and the duration of each group of resting state are related Preconfigured jointly; determining the analysis result in the current stroke rehabilitation state of the subject according to the acquired first blood oxygen concentration signal and the second blood oxygen concentration signal; and displaying the determined current stroke recovery state of the subject The analysis results below.

According to a second aspect of the present application, a stroke rehabilitation analysis system is provided, including: a headgear for wearing on a subject's head, the headgear is provided with multiple probes for transmitting and/or receiving near-infrared signals to collect Near-infrared signals of a plurality of corresponding channels, and thereby obtain blood oxygen concentration signals of a plurality of corresponding channels; a processor configured to: when the subject performs a set of alternating tasks of upper limb movement and resting state, The plurality of probes are caused to acquire at least the first blood oxygen concentration signal of each channel corresponding to the left brain area of the upper limb movement, and at least the second blood oxygen concentration signal of each channel corresponding to the right brain area of the upper limb movement. , wherein the number of groups of alternating tasks, the duration of each group of upper limb movements and the duration of each group of resting states are pre-configured in association; according to the acquired first blood oxygen concentration signal and the second blood oxygen concentration signal, Determining the analysis results in the current stroke rehabilitation state of the subject; and a display configured to display the determined analysis results in the current stroke recovery state of the subject.

According to a third aspect of the present application, a computer-readable storage medium is provided with computer program instructions stored on the computer-readable storage medium. When the computer program instructions are run by a processor, the computer program instructions cause the processor to execute various aspects of the present application. Methods for stroke rehabilitation analysis using near-infrared functional brain imaging devices described in the embodiments.

Compared with the prior art, the beneficial effects of the embodiments of the present application are:

When stroke patients perform stroke rehabilitation analysis, they perform alternating tasks of upper limb movement and resting states in groups. The resting phase provides the blood oxygen concentration benchmark of the current group, allowing real-time and accurate changes in blood oxygen concentration to be obtained, thereby obtaining more accurate results. Analysis of current stroke recovery status. Based on the analysis method, the evaluation of stroke rehabilitation analysis can be completed in a short time, especially suitable for patients with severe stroke, the subject compliance is high, and the data of each channel corresponding to the left brain area of the upper limb movement is collected in a targeted manner. The first blood oxygen concentration signal and the second blood oxygen concentration signal of each channel in the right brain area are not the blood oxygen concentration signals of each channel in the generalized brain area. Upper limb movement will generate stronger signals in the corresponding brain area. A more concentrated, consistent, and stronger blood oxygen concentration signal can be obtained with upper limb movement. Based on this, the analysis results of the current stroke recovery state can be determined, which is beneficial to eliminating interference and improving accuracy.

Both the foregoing general description and the following detailed description are exemplary and explanatory only and are not intended to limit the claimed invention.

Description of the drawings

In the drawings, which are not necessarily to scale, the same reference numbers may describe similar components in the different views. Similar reference numbers with a letter suffix or different letter suffixes may represent different examples of similar components. The drawings illustrate various embodiments generally by way of example and not limitation, and together with the description and claims serve to explain the disclosed embodiments. Where appropriate, the same reference numbers will be used throughout the drawings to refer to the same or similar parts. Such embodiments are illustrative and are not intended to be exhaustive or exclusive embodiments of the system or method.

Figure 1(a) shows a flow chart of a method for stroke rehabilitation analysis using a near-infrared functional brain imaging device according to an embodiment of the present application.

Figure 1(b) shows another flow chart of a method for stroke rehabilitation analysis using a near-infrared functional brain imaging device according to an embodiment of the present application.

Figure 2 shows a graphical representation of a representative HbO2 distribution curve (201), a representative HbR distribution curve (202) and a representative HbT (203) distribution curve obtained according to an embodiment of the present application and displayed against the time axis.

Figure 3 shows a diagram of an activation map obtained by performing stroke rehabilitation analysis using a near-infrared brain functional imaging device according to an embodiment of the present application.

Figure 4(a) shows a diagram of the analysis results obtained by performing stroke rehabilitation analysis using a near-infrared brain functional imaging device according to an embodiment of the present application in the current stroke rehabilitation state, in which the stroke rehabilitation indicators of the subject are collaboratively displayed.

FIG. 4(b) illustrates a processing example for determining the activity of the left and right brain regions based on the blood oxygen concentration signal according to an embodiment of the present application.

Figure 4(c) shows a diagram of the analysis results obtained by performing stroke rehabilitation analysis using a near-infrared brain functional imaging device according to an embodiment of the present application in the current stroke rehabilitation state, in which the stroke rehabilitation indicators of the subject are collaboratively displayed.

Figure 5 shows a schematic diagram of a stroke rehabilitation analysis system according to an embodiment of the present application.

Detailed ways

In order to enable those skilled in the art to better understand the technical solutions of the present application, the present application will be described in detail below in conjunction with the drawings and specific implementation modes. The embodiments of the present application will be further described in detail below in conjunction with the accompanying drawings and specific examples, but this is not intended to limit the present application.

The words "first", "second" and similar words used in this application do not indicate any order, quantity or importance, but are only used to distinguish the names of parts. Similar words such as "include" or "include" mean that the elements before the word include the elements listed after the word, and do not exclude the possibility of also covering other elements. "Up", "left", "right", etc. are only used to express relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

All terms (including technical terms or scientific terms) used in this application have the same meanings as understood by one of ordinary skill in the art to which this application belongs, unless otherwise specifically defined. It should also be understood that terms defined in, for example, general dictionaries should be construed to have meanings consistent with their meanings in the context of the relevant technology and should not be interpreted in an idealized or highly formalized sense, except as expressly stated herein. Define it this way. Techniques, methods and devices known to those of ordinary skill in the relevant art may not be discussed in detail, but where appropriate, such techniques, methods and devices should be considered a part of the specification.

Figure 1(a) shows a flow chart of a method for stroke rehabilitation analysis using a near-infrared functional brain imaging device according to an embodiment of the present application. Wherein, the near-infrared functional brain imaging device has a headgear for wearing on the subject's head, and the headgear is provided with multiple probes for transmitting and/or receiving near-infrared signals to collect multiple corresponding channels of near-infrared signals. signal, and obtain blood oxygen concentration signals of multiple corresponding channels accordingly. A curve of the blood oxygen concentration signal of the channel changing with time can be drawn based on the obtained near-infrared signal of the corresponding channel. The blood oxygen concentration signal obtained by converting the near-infrared signal can represent the blood oxygen concentration change of the cerebral cortex, and can be used To show the dynamic characteristics of neural responses under different conditions. In the process of stroke rehabilitation analysis using a near-infrared brain functional imaging device, the near-infrared light and the transmitting probe-receiving probe on the headgear form a multi-channel sensor, collecting near-infrared signals of multiple corresponding channels, based on the nerve-blood oxygen coupling mechanism , effectively visualize and quantitatively assess the brain functional status of stroke patients.

As shown in Figure 1(a), in step S101a, in the case where the subject performs a set of alternating tasks of upper limb movement and resting state, using the plurality of probes, at least the left side corresponding to the upper limb movement is acquired. The first blood oxygen concentration signal of each channel of the brain area, and the second blood oxygen concentration signal of each channel of the right brain area corresponding to at least the upper limb movement. The group of alternating tasks of upper limb movement and resting state may be multiple groups or a single group of alternating tasks of upper limb movement and resting state, so as to be adapted to stroke patients with different severity of illness, for example, for patients who are unable to hear tasks. Instructions or severe stroke patients The user can perform a single set of alternating tasks of upper limb movement and resting state. When stroke patients perform upper limb movements, based on the neurovascular coupling mechanism, the stimulation of upper limb movements can cause the neurons responsible for processing related stimuli to start working. The metabolic activity of the brain tissue where these neurons are located will increase and cause local tissue blood to Oxygenated hemoglobin (HbO2) decreases. At this time, the overcompensation mechanism of the brain's blood supply system will inject a large amount of blood containing rich oxyhemoglobin into the local area, resulting in an increase in the local blood oxygen concentration and inducing a blood oxygen response. Moreover, as the upper limbs move, the blood oxygen response continues to accumulate. Use a near-infrared brain functional imaging device to collect near-infrared signals of each channel in the left and right brain areas corresponding to upper limb movement. The near-infrared signals can characterize the brain activity of the corresponding brain areas. Therefore, the near-infrared signals can be Converted into a blood oxygen concentration signal, for example, the blood oxygen response curve drawn based on the collected near-infrared signal can reflect the neuronal activity and change patterns in the corresponding brain area.

Wherein, the number of groups of the alternating task, the duration of each group of upper limb movements and the duration of each group of resting states are pre-configured in association. By pre-configuring the number of groups of alternating tasks, the duration of each group of upper limb movements, and the duration of each group of resting state, it can be adapted to stroke patients with different degrees of illness and improve the patient's cooperation in stroke rehabilitation analysis.

In step S102a, the analysis result of the subject's current stroke recovery state is determined based on the acquired first blood oxygen concentration signal and the second blood oxygen concentration signal. The near-infrared brain functional imaging device is used to collect the near-infrared signals of each channel corresponding to the brain area. The blood oxygen concentration signal can be obtained based on the conversion of the collected near-infrared signals, and the HbO2 distribution curve and HbR distribution in the time domain of each channel can be determined. curve and HbT distribution curve, etc., as the analysis results of the subject's current stroke recovery status. In step S103a, the determined analysis results of the subject's current stroke rehabilitation state are displayed, so that doctors and stroke patients can visually understand the recovery state of the stroke patient.

In some embodiments of the present application, when the duration of each group of upper limb movements and the duration of each group of resting states are pre-configured within a predetermined time range, the number of groups of alternating tasks is pre-configured to be less than the predetermined number of groups, In order to adjust the number of groups performing tasks and the duration of upper limb movements according to the severity of stroke patients, thereby improving the cooperation of stroke patients and obtaining a more reliable blood oxygen concentration signal. For example, if the number of preconfigured groups is high, when a stroke patient performs multiple groups of alternating tasks of upper limb movement and resting state, the stroke patient may not be able to sustain upper limb movement for a long time. In this case, based on the obtained blood oxygen concentration The signal cannot accurately determine the stroke patient's current recovery status. In a specific embodiment, the predetermined number of groups can be estimated according to the predetermined time range, and then the duration of the upper limb movement and the duration of each group of resting state are pre-configured to be shorter than Some, and the configured number of groups is less than the predetermined number of groups, so that stroke patients can perform multiple groups of tasks. Among them, the number of groups of alternating tasks is preconfigured to be less than the predetermined number of groups, which can enable stroke patients to maintain a relatively stable state of cooperation when performing each group of alternating tasks, and reduce the risk of patient cooperation caused by too many groups of alternating tasks performed by stroke patients. Poor, thus the acquired blood oxygen concentration signal cannot objectively reflect the negative impact of the patient's true stroke recovery status. For another example, if a stroke patient is severely ill and unable to perform multiple sets of tasks, the number of sets of alternating tasks can be preset to a single set. Preferably, the predetermined time range is 2 minutes to 5 minutes, and the alternating tasks are pre-configured as a single group. The applicant has experimentally verified that when the duration of each group of upper limb movements and the duration of each group of resting state are pre-configured within the time range of 2 minutes to 5 minutes, the blood levels obtained by stroke patients performing a single group of alternating tasks are The oxygen concentration signal, using the stroke rehabilitation analysis methods of various embodiments of the present application, can also accurately reflect the rehabilitation status of stroke patients.

Next, a set of alternating tasks of upper limb movement and resting state, including an array of alternating tasks of upper limb movement and resting state, will be described as an example.

As shown in Figure 1(b), step S101b discloses using the plurality of probes to obtain several segments of the first blood oxygen concentration signal when the subject performs an array of alternating tasks of upper limb movement and resting state. (obtained through acquisition and conversion through each channel of the left brain area corresponding to upper limb movement) and several second blood oxygen concentration signals (obtained through acquisition and conversion through each channel of the right brain area corresponding to upper limb movement), wherein, Each segment of the first blood oxygen concentration signal and the second blood oxygen concentration signal corresponds to each group of tasks respectively. Each set of tasks includes an upper limb movement phase and a resting phase, that is, each section of the first blood oxygen concentration signal and the second blood oxygen concentration signal includes an upper limb movement phase and a resting phase. For each channel, a set of alternating upper limb exercise and rest tasks will result in a continuous blood oxygen concentration signal over a period of time, which can avoid baseline drift compared to a blood oxygen concentration signal that is continuously obtained over a period of tens of minutes. , ensuring the stability of the blood oxygen concentration signal in each segment. The brain area may be a motor area corresponding to upper limb movement, and the subjects include but are not limited to patients with mild stroke, patients with moderate stroke, patients with severe stroke, etc. This application does not specifically limit this. It is understandable that some stroke patients have damage to their motor areas, making it difficult for them to perform some movement actions, such as grasping movements, flexion and extension movements, etc. Such stroke patients generally need to perform corresponding rehabilitation training tasks according to medical instructions. Improve their motor function.

It should be noted that, generally speaking, the training time for rehabilitation training tasks performed by stroke patients is at least ten minutes, or even dozens of minutes, to achieve the desired training effect. In this embodiment, the sum of the durations of the array tasks is shorter than the training time for the subject to perform rehabilitation training tasks. The upper limit of each group The duration of limb movement can be more than ten seconds or tens of seconds, the duration of the rest phase can also be more than ten seconds or tens of seconds, and the total duration of executing array tasks can be several minutes, such as 3 minutes, 5 minutes, etc. , is far less than the training time for the subject to perform rehabilitation training tasks, making the patient's compliance higher, and processing the obtained blood oxygen concentration signal can obtain a more stable and accurate blood oxygen concentration signal corresponding to each group of tasks , performing stroke rehabilitation analysis based on the blood oxygen concentration signal of each group of tasks or the representative blood oxygen concentration signal obtained based on the blood oxygen concentration signal of each group of tasks can improve the accuracy of the analysis.

It can be understood that the upper limb movements performed by the subject used for stroke rehabilitation analysis may be the same as or different from the movement manner in which the subject performs rehabilitation training tasks. That is, the rehabilitation training tasks performed by the subject may be upper limb movements, or It can be other movements, such as limb linkage movement, grasping movement, etc., which are not specifically limited in this application.

When the subject performs an array of upper limb movement and rest alternating tasks, the so-called array includes but is not limited to 1 group, 2 groups, 3 groups, 4 groups, etc. The specific number of groups performed can be based on the doctor's requirements or specific analysis requirements. , this application does not specifically limit this. For example, when conducting stroke rehabilitation analysis on a severe patient with hemiplegia, the patient wears a headgear with a near-infrared functional brain imaging device. At the request of the doctor, the severely ill patient can perform upper limb movements for several seconds and then rest for several seconds. A total of 3 groups were performed, using the probe on the headgear to collect near-infrared signals for subsequent analysis. The time for upper limb exercise and the time for rest can be the same or different. For example, the patient can perform upper limb exercise for 15 seconds and then rest for 20 seconds. The resting phase of each group provides the blood oxygen concentration baseline of the current group. Based on the blood oxygen concentration baseline of the current group and the blood oxygen concentration value during upper limb exercise of the current group, the blood oxygen concentration change data of the current group can be obtained, and the real-time performance is relatively high. Well, it can significantly reduce the influence of drift, and based on this, more accurate and reliable analysis results in the current stroke rehabilitation state can be obtained. In this embodiment, the specific work of the patient's upper limb movement can be completed under the guidance of a doctor, or the patient can be completed based on the prompts of the near-infrared brain functional imaging device. When performing the alternation of upper limb movement and rest, the patient can lie down or stand to complete the exercise. For example, during the rehabilitation analysis process for severe stroke patients, the patient cannot stand. Due to the simplicity of the analysis method in this embodiment, the patient can complete the upper limb movement while lying on the bed. Alternate tasks with rest. Therefore, the method provided by this embodiment is not only suitable for patients with mild stroke, but is especially suitable for patients with severe stroke, and the method has high compliance for patients. Of course, for mild stroke patients who can stand and walk, there are many options for performing the procedure, which can be done standing or lying down. The method provided by this embodiment has high training compliance and low execution difficulty, which greatly improves the efficiency of rehabilitation analysis execution.

Specifically, the plurality of probes are used to obtain several segments of blood oxygen concentration signals of each channel of the bilateral brain areas corresponding to at least the movement of the upper limbs. There is no specific limit on the number and type of probes on the headgear, as long as It can be used to obtain blood oxygen concentration signals that meet the requirements. The headgear of the near-infrared brain functional imaging device is equipped with a probe for collecting near-infrared signals. A pair of probes are arranged to form a channel. When used, the channel formed by the probes on the headgear corresponds to the pair of probes on the user's head. For the lateral brain area, it is determined that the obtained blood oxygen concentration signal specifically represents the physiological state of the bilateral brain area corresponding to the upper limb movement. Among them, positioning software can be used to perform positioning work for bilateral brain areas, or other methods can be used to achieve it.

During the patient's rehabilitation training, the training time is relatively long. Depending on the patient's condition, the training time may range from ten minutes to an hour. However, in the stroke rehabilitation analysis method provided in this embodiment, the duration for patients or other research subjects to perform a set of tasks is shorter than the training time for rehabilitation training exercises, resulting in less frequency band interference. Compared with the continuous collection of blood oxygen for dozens of minutes, concentration signal, which can significantly reduce drift. This embodiment can complete the evaluation within a few minutes, improves the analysis efficiency, and can reduce the burden on the subject.

In step S102b, the analysis result of the subject's current stroke recovery state may be determined based on the segments of first blood oxygen concentration signals and the segments of second blood oxygen concentration signals. Next, in step S103b, the analysis results of the determined current stroke rehabilitation state of the subject may be displayed. The blood oxygen concentration in human tissue will change with the metabolic activity of the human body. This change can be measured using near-infrared light. Therefore, each channel can be determined based on the first blood oxygen concentration signal of several segments and the second blood oxygen concentration signal of several segments. The HbO2 distribution curve, HbR distribution curve, HbT distribution curve, etc. in the time domain are used as the analysis results of the subject's current stroke recovery status. As a result, the hemodynamic activity of the cerebral cortex can be detected in real time and directly. By observing this hemodynamic change, that is, through the neurovascular coupling law, the brain activity can be inferred. In the above embodiment, a near-infrared functional brain imaging device is used for stroke rehabilitation analysis, and an array of tasks is used. Each group of tasks alternates between upper limb movement and rest, and the duration is a few seconds, such as 10-30 seconds. Regarding the properties of the blood oxygen concentration signal, Generally speaking, there is less frequency band interference, and the drift is significantly reduced compared to continuous collection for more than ten minutes. The evaluation can be completed in a few minutes, and the subject compliance is high. The rest phase of each group provides the blood oxygen concentration benchmark of the current group. Based on the current The blood oxygen concentration benchmark of the group and the blood oxygen concentration value during upper limb exercise of the current group can obtain the data of the blood oxygen concentration change of the current group, and the real-time performance is good, which can significantly reduce the influence of drift. Based on this, a more accurate and reliable The analysis results of the current stroke rehabilitation state are analyzed, and the blood oxygen concentration signals of each channel are collected in a targeted manner corresponding to the bilateral brain areas corresponding to upper limb movements rather than generalized brain areas. It will generate a stronger signal in the corresponding brain area, and can obtain a more concentrated, consistent and stronger blood oxygen concentration signal with the movement of the upper limbs. Based on this, the analysis results of the current stroke recovery state can be determined, which will help eliminate interference and improve accuracy.

It can be understood that the solution disclosed in this application can be used to analyze the rehabilitation status of stroke patients who improve their motor functions by performing rehabilitation training tasks, and can also be used to analyze the rehabilitation status of stroke patients who do not need to perform rehabilitation training tasks, such as , stroke patients who are deemed by their doctors to not need to perform rehabilitation training tasks after therapeutic intervention.

In some embodiments, determining the analysis result of the subject's current stroke recovery state based on the segments of first blood oxygen concentration signals and the segments of second blood oxygen concentration signals specifically includes: for each channel, based on the The signal intensity at the beginning of each segment of the blood oxygen concentration signal of the channel is corrected to eliminate the drift effect. Specifically, during the acquisition process, the baseline of the blood oxygen concentration signal corresponding to each group of tasks will drift. By aligning the signal intensity at the beginning of each segment of the blood oxygen concentration signal in the channel, the drift effect can be eliminated. Improve the accuracy of analysis results.

In some embodiments, the average of each corrected blood oxygen concentration signal of the channel can be used as the representative blood oxygen concentration signal of the channel. A stable and accurate representative blood oxygen concentration signal can be quickly obtained based on each channel. The representative blood oxygen concentration signal determines the analysis results of the subject's current stroke recovery state, which is beneficial to reducing workload and further improving the accuracy of the analysis results. The representative blood oxygen concentration signal is intended to reflect the overall situation of the blood oxygen concentration signal of each channel and avoid large deviations, which may lead to large errors in judgment.

In some embodiments, as shown in Figure 2, the analysis results of the subject's current stroke recovery state include representative HbO2 distribution curves 201, representative HbR distribution curves 202 and Representative HbT distribution curve 203, and the representative HbO2 distribution curve 201, representative HbR distribution curve 202 and representative HbT distribution curve 203 in the time domain are displayed in comparison on the same time axis. The so-called representative distribution curve can be obtained in various ways. For example, a representative channel can be selected, and the distribution curve (or time domain average distribution curve) of the representative channel can be obtained as the representative distribution curve. For another example, the distribution curve of each channel can also be obtained and a representative curve (such as but not limited to an average curve) can be obtained as a representative distribution curve.

The representative HbO2 distribution curve 201, the representative HbR distribution curve 202 and the representative HbT distribution curve 203 can be comparatively displayed on the same time axis, which is convenient for doctors to view and intuitively evaluate the blood oxygen response effect. When the subject performs the task, a near-infrared brain functional imaging device is used to obtain its The blood oxygen concentration changes in the bilateral brain areas, and the hemodynamic activity is highly related to the task design. It can be inferred that the brain area is activated under the task state and has a better blood oxygen response effect.

As shown in Figure 2, the blood oxygen concentration value in the time domain of this group of tasks shows a trend of rising first, reaching a peak and then declining. This regular distribution curve shows that the blood oxygen response effect is better. The blood oxygen response effect can be used as a reference factor for stroke rehabilitation analysis and can overturn the results of other analyzes with high recovery levels. For example, even if the activation map shows a high level of recovery, but the blood oxygen response is abnormal, it cannot be certain that the analysis conclusion of the activation map is credible. The doctor can note the quality of the blood oxygen response in the report for subsequent diagnosis. Poor blood oxygen response may be caused by low recovery level, or may be caused by detection failure of the near-infrared device or improper operation during the collection process. In some embodiments, prompt information may be displayed to the doctor when the blood oxygen response is poor.

In some embodiments, the acquired first blood oxygen concentration signal and the second blood oxygen concentration signal are each of several segments, and according to the several segments of the first blood oxygen concentration signal and the several segments of the second blood oxygen concentration signal Determining the analysis results of the subject's current stroke recovery state specifically includes: based on the acquired first blood oxygen concentration signals of several segments, the second blood oxygen concentration signals of several segments and the acquired channels of each channel in the peripheral brain area. Several segments of the third blood oxygen concentration signal determine the activation map of the subject's brain area, as shown in Figure 3. The distribution regularity of the color blocks in the activation map represents the stroke recovery level of the subject. The color in the activation map If the first distribution regularity of the patch is compared to the second distribution regularity of the color patch in the activation spectrum that is lower than the first distribution regularity, then the former situation has (represents) a higher level of stroke recovery.

Specifically, as shown in Figure 3, the activation map not only reflects the activation of the brain area corresponding to the upper limb movement, but also shows the activation of surrounding related brain areas adjacent to it. The color blocks are distributed in the brain area corresponding to the upper limb movement and related to the upper limb movement. The regularity of adjacent surrounding related brain areas allows doctors to determine the level of stroke recovery at a glance. When the patient's stroke recovery level is high, it means that the brain area responds regularly to upper limb movement. At this time, if the first distribution regularity of the color patches in the first activation map is higher than that of the color patches in the second activation map With the second distribution regularity, it can be judged that the subject to which the first activation spectrum belongs has a higher stroke recovery level. The color blocks of the activation map are distributed with high regularity, and users can quickly judge the stroke rehabilitation effect based on the regularly distributed color blocks. When the patient's stroke recovery level is low, there is a lag or even no response in the brain area to the upper limb movement. Even if the upper limb movement is performed, the brain area has a lag response or even no response, indicating that the brain area is not quickly activated or even not activated by the upper limb movement. is activated. At this time, the distribution regularity of the activation map is poor. Based on the unevenly distributed and irregular color blocks, the user can quickly judge that the stroke recovery level is low and further rehabilitation training is needed, and it can be carried out for a period of time. Stroke rehabilitation analysis was performed again after rehabilitation training.

In some embodiments, as shown in Figure 3, the activation map can be displayed on a partial two-dimensional brain image, that is, a non-complete two-dimensional brain image, as long as it contains the brain areas that need to be displayed, so that it can be displayed in a limited area. The activation map is highlighted in the display area, allowing doctors to clearly view the activation map and make more accurate judgments.

The method provided by this embodiment presents the activation map of the brain area to the user. The color blocks in the activation map show a regular correlation with the response of the brain area to upper limb movement. The user observes whether the color blocks of the activation map show regular distribution, It can intuitively and quickly determine the level of stroke rehabilitation, improve the efficiency of stroke rehabilitation analysis, and reduce the user's workload.

In some embodiments, the analysis results of the subject's current stroke recovery state also include an activation map of the subject's brain area, and the distribution regularity of the color patches in the activation map represents the stroke recovery level of the subject, If the first distribution regularity of the color patches in the activation spectrum is compared with the second distribution regularity of the color patches in the activation spectrum that is lower than the first distribution regularity, then the former situation has (represents) a higher level of stroke recovery, The activation map includes a 2D activation map and/or a 3D activation map, so that the user can intuitively and quickly determine the stroke recovery level.

Figure 4(a) shows a diagram of the analysis results obtained by performing stroke rehabilitation analysis using a near-infrared brain functional imaging device according to an embodiment of the present application and simultaneously displaying the stroke rehabilitation indicators of the subject in the current stroke rehabilitation state. As shown in Figure 4(a), displaying the determined analysis results of the subject's current stroke recovery state specifically includes displaying the activation map of the subject's brain area in the first area 401, and displaying the activation map of the subject's brain area in the first area 401. The second area 402 other than the area 401 displays a representative HbO2 distribution curve (a curve at the middle position of the upper limb movement area), a representative HbR distribution curve (a curve at the lower position of the upper limb movement area), and a representative HbT distribution in the time domain. Curve (the curve above the upper limb movement area). For example, the second area 402 may also include a right movement area 4021 and a left movement area 4022, and each of the right movement area 4021 and the left movement area 4022 respectively displays a representative HbO2 distribution curve in the time domain (the curve at the middle position of the upper limb movement area ), the representative HbR distribution curve (the curve below the upper limb movement area) and the representative HbT distribution curve (the curve above the upper limb movement area).

The joint presentation of the activation map and the three distribution curves can meet the actual needs of doctors and facilitate doctors' comprehensive consideration of all aspects of the analysis results in the current stroke rehabilitation state. For example, doctors can check the distribution curve to evaluate the blood oxygen response effect. If the blood oxygen response effect is good, then check the activation map. The activation map not only reflects the activation of the brain area corresponding to the upper limb movement, but also shows the activation of surrounding related brain areas. Color The regularity of block distribution allows doctors to determine the level of stroke recovery at a glance. If the blood oxygen response effect and the distribution regularity of the activation map are relatively good, it can be used with higher confidence High levels of stroke recovery were determined. However, when the blood oxygen response is poor, doctors do not need to view and analyze activation maps, which helps reduce unnecessary workload for doctors.

In some embodiments, the activation map of the subject's brain area can be displayed in the first area, and the representative HbO2 distribution curve and representative HbO2 distribution curve in the time domain can be displayed in a second area other than the first area. HbR distribution curve and representative HbT distribution curve, the doctor can selectively view the activation map according to the blood oxygen response effect reflected by the distribution curve, making the interface clearer and concise, and the information obtained by the doctor is more concentrated, which is conducive to the doctor's judgment of the analysis results. .

In some embodiments, returning to Figure 3, the distribution regularity of the color patches in the activation map includes the dispersion and mutation degree of the color patches. The higher the dispersion and mutation degree, the lower the distribution regularity. The color patches of the activation map are distributed in a regular layout, with a high degree of dispersion. For example, the active color patches are scattered in different positions. The degree of mutation is high. For example, the active color patch does not smoothly gradually change into an inactive color patch, but jumps and mutates into an inactive color patch. The color patches The degree of dispersion and mutation are both highly sensitive and easy to identify for the human eye, which is beneficial to reducing the workload of doctors and ensuring the accuracy and efficiency of identification.

In some embodiments, the analysis results of the subject's current stroke recovery state also include the subject's stroke recovery indicators, and the stroke recovery indicators include the subject's left brain area activity, right brain area activity Spend. In a specific embodiment, the activity level can be determined based on the blood oxygen concentration signal during upper limb exercise and the baseline blood oxygen concentration signal during rest, which is beneficial to eliminating interference and improving accuracy. The blood oxygen concentration benchmark of the current group is provided during rest. Based on the blood oxygen concentration signal of the current group during upper limb exercise and the benchmark blood oxygen concentration signal of the current group during rest, timely and effective activity can be obtained, thereby improving Accuracy of analytical results in current stroke recovery status.

Specifically, determining the analysis result of the subject's current stroke recovery state based on the acquired first blood oxygen concentration signal and the second blood oxygen concentration signal specifically includes: based on the representativeness of at least part of the channels in the left brain region The signal strength of the blood oxygen concentration signal within the first preset time window during upper limb exercise and the signal strength within the second preset time window during rest are used to determine the activity of the left brain region of the subject. For example, the subject is asked to perform a set of tasks, performing upper limb movements within 0-20s and resting within 20-40s. The first preset time window can be understood as a time period within 0-20s. For example, the second preset time window from 5th to 20s can be understood as a time period within 20th to 40s, such as 25th to 40s. If the signal intensity when performing upper limb movements is much higher than the signal intensity when performing rest, it can be determined that the activity in the left brain area is higher, which can also provide a reference for determining stroke recovery. This specific implementation is only an example and does not limit the specific comparison method. There is no specific limitation on the comparison method of signal strength.

Similar to the method for determining the activity of the left brain region, the signal intensity of the representative blood oxygen concentration signal of at least part of the channel of the right brain region within the first preset time window during upper limb exercise is compared with the second during rest. The signal intensity within the preset time window is used to determine the activity of the right brain area of the subject.

In some other embodiments, further, in conjunction with the layout of the stroke recovery indicator 403 in Figure 4(a), based on the representative blood oxygen concentration signal of each channel, determining the analysis result of the subject's current stroke recovery state also includes The balance degree 4033 of the brain areas on both sides is determined based on the ratio of the difference between the activity degree 4031 of the left brain area and the activity degree 4032 of the right brain area and the sum of the activity degree 4031 of the left brain area and the activity degree 4032 of the right brain area. Among them, the smaller the balance degree of the brain areas on both sides, the smaller the difference between the activity degree of the left brain area and the right brain area. There is no major deviation between the left brain area and the right brain area, indicating that the patient The recovery status is better. Specifically, for example, if a stroke patient's left brain area is in good condition and the right brain area belongs to the affected side, after a period of rehabilitation exercise training, when the rehabilitation status of the patient's right brain area is analyzed. , it was found that the difference in activity between the left brain area and the right brain area was large, and the balance of the brain areas on both sides was relatively large. The doctor could think that the recovery status of the patient's right brain area was poor. If the recovery of the left brain area and the right brain area of a stroke patient during the rehabilitation process are better, then the difference between the left brain area activity 4031 and the right brain area activity 4032 is small, based on this determination The balance degree 4033 of the brain areas on both sides is also relatively small, indicating that the recovery of the brain areas on both sides is balanced.

Three stroke recovery indicators, namely left brain area activity, right brain area activity and balance of both sides of the brain, are provided to doctors for analyzing the subject's stroke recovery level, further improving the current stroke recovery status The accuracy of the analysis results is improved and the credibility of the results is improved.

In other embodiments, the doctor can also be provided with the baseline values of each activity degree and the balance degree of the brain areas on both sides, such as the activity degree of the left brain area 4031, the activity degree of the right brain area 4032, and the balance degree of the brain areas on both sides 4033. The size can be limited based on actual conditions. For example, it can be set when the device leaves the factory to provide a basis for judging stroke rehabilitation indicators. In other embodiments, modifiable methods can also be provided to the user. For example, doctors can set settings for different patients, disease levels, etc., to achieve personalized treatment and further improve the analysis results of the current stroke rehabilitation state. Accuracy and credibility. Among them, the index sizes of the left brain area activity 4031 and the right brain area activity 4032 can be the same or different, and are not specifically limited.

In some embodiments, as shown in Figure 4(a), the analysis results of the subject's current stroke recovery state also include the subject's stroke recovery indicators, and the stroke recovery indicators include the subject's left brain area activity. degree 4031, activity degree of right brain area 4032 and balance degree of both sides of brain area 4033; display all The determined analysis results of the subject's current stroke recovery state specifically include: displaying the subject's stroke recovery indicators in a third area 403 other than the first area 401 and the second area 402 . For example, Figure 4(a) shows that while the activation map is displayed in the first area 401, the left brain area activity 4031, the right brain area activity 4032, and the balance degree 4033 of both sides of the brain area are displayed in the third area 403.

During the analysis process, the three analysis results are jointly displayed in partitions, which is helpful for doctors to integrate the three analysis results to obtain a more accurate stroke rehabilitation level, thereby improving the accuracy of the analysis results under the current stroke rehabilitation status. As for the specific display method, the user interface can simultaneously display the activity degree 4031 of the left brain area, the activity degree 4032 of the right brain area, and the balance degree 4033 of the brain areas on both sides at the same time, or it can also include when the user indicates which analysis result to display. The system responds based on the instruction and displays the analysis results of the response. For example, when the user wants to obtain the left brain area activity 4031, after performing the corresponding selection, the left brain area activity 4031 is displayed on the interactive interface; when the user If the user wants to compare the obtained right brain area activity 4032 with the stroke rehabilitation index, the user can display the stroke rehabilitation index based on the instruction of selecting the stroke rehabilitation index. The interactive interface can display the required analysis results based on the user's selection, and the specific display method is not specifically limited.

In some embodiments, when the subject performs an array of alternating tasks of upper limb movement and resting state, the duration of each group of upper limb movement is 5-50 seconds, such as 5 seconds, 10 seconds, 20 seconds, 30 seconds, 40 seconds. seconds, 50 seconds, etc., preferably 10-40 seconds. The rest duration of each group is 5-50 seconds, such as 5 seconds, 10 seconds, 20 seconds, 30 seconds, 40 seconds, 50 seconds, etc., preferably 10-40 seconds. Each set of tasks is performed in a shorter period of time. There is less frequency band interference for the properties of the blood oxygen concentration signal. Compared with the method of continuous collection for more than ten minutes, the drift is significantly reduced. The entire evaluation can be completed in a few minutes. Object compliance higher. In addition, in this embodiment, the total time for performing each set of tasks including upper limb movement and rest is 10-100 seconds. Within this range, the blood oxygen concentration signal for stroke rehabilitation analysis can be obtained accurately and effectively to avoid more interference. , reducing the accuracy of assessment. The time period provided by this embodiment includes frequency bands useful for evaluating the analysis results in the current stroke rehabilitation state, which not only meets the needs for evaluation of the analysis results in the current stroke rehabilitation state, but also reduces the execution difficulty for patients. The patient's acceptance is high and it can improve the patient's cooperation.

Specifically, for example, the subject performs upper limb exercise for 15 seconds and rests for 20 seconds. This is one group, and a total of 5 groups are performed. The analysis of the subject's stroke recovery status can be completed within 3 minutes for reference. The doctor's reference allows the doctor to give the subject corresponding rehabilitation suggestions, which greatly improves work efficiency and reduces the burden on the subject. For example, some patients with severe stroke can only perform simple exercises for a short period of time after recovering for a period of time. At this time, the patient is unable to perform exercises for a long time. Ten minutes or even dozens of minutes of exercise. However, using the method of this embodiment for severe stroke patients can greatly reduce the difficulty of exercise for this type of patients, providing a more efficient analysis method for rehabilitation analysis of severe stroke patients.

In some embodiments, based on the acquired first blood oxygen concentration signal and the second blood oxygen concentration signal, other methods can also be used to determine the activity of the left brain area and the right brain area of the subject, The following description takes the execution of a single set of alternating tasks of upper limb movement and resting state as an example. This is only used as an example, but is not limited to this. For example, the duration of upper limb movement is 2-4 minutes, and the duration of resting state is 2-4 minutes. Preferably, the duration of the upper limb movement is 3 minutes, and the duration of the resting state is also 3 minutes.

Even if the subject performs the above-mentioned single set of alternating tasks, the obtained first blood oxygen concentration signal and the second blood oxygen concentration signal can be objectively and accurately reflected by using the processing flow shown in Figure 4(b). The level of stroke recovery depends on the activity of the left brain region and the activity of the right brain region.

As shown in Figure 4(b), in step S404, wavelet transform is performed on the signal segment corresponding to the acquired first blood oxygen concentration signal during upper limb movement, and the corresponding time domain-frequency signal is obtained within the preset frequency band of the wavelet transform result. The first representative amplitude in the domain spectrum. In step S405, perform wavelet transformation on the signal segment corresponding to the upper limb movement period of the second blood oxygen concentration signal obtained, and obtain the second representative amplitude in the corresponding time domain-frequency domain spectrum within the preset frequency band of the wavelet transformation result. value, the second representative amplitude having a definition consistent with the first representative amplitude. In step S406, the activity of the left brain area of the subject is determined based on the first representative amplitude of each channel of the left brain area corresponding to the upper limb movement, and based on the right brain area corresponding to the upper limb movement The second representative amplitude of each channel of the area is used to determine the activity of the right brain area of the subject. Specifically, according to the wavelet transformation result, trapezoidal integration can be performed in the frequency domain of the preset frequency band to obtain the average wavelet amplitude of the first blood oxygen concentration signal and the second blood oxygen concentration signal data sequence as the third blood oxygen concentration signal. a representative amplitude and a second representative amplitude.

The color of the color block in the activity map shown in Figure 4(c) can be used to represent the activity of the left and right brain areas. The larger the value, the greater the activity. Doctors can intuitively obtain the activity status of the left and right brain areas through the activity map displayed on the interface.

Specifically, the preset frequency band can be a low frequency or ultra-low frequency centered on 0.1 Hz or 0.04 Hz. Within this frequency range, the impact of low-frequency drift and physiological noise (respiration, heartbeat, etc.) on the neural activity signals in the cortical area can be avoided. influence, so that more accurate data can be obtained.

In addition, the method described in the above embodiment of obtaining the activity of the brain areas on both sides through the signal intensity and determining the balance of the brain areas on both sides based on the activity of the brain areas on both sides is also applicable here.

In some embodiments, the method further includes, while displaying the value of the balance degree of the two sides of the brain area, prompting the grading level of the balance status of the two sides of the brain area. In a preferred embodiment, it specifically includes at least one of the following: when the value of the balance degree of the two sides of the brain area is -0.15 to 0.15, it indicates a high level of the balance degree of the two sides of the brain area and/or both sides. Low level of lateralization of brain regions; when the value of the balance between the two sides of the brain is -0.4 to -0.15, or 0.15 to 0.4, and not -0.4 and 0.4, it indicates the balance of the two sides of the brain Moderate level and/or moderate level of lateralization of both brain regions; when the value of the balance of the bilateral brain regions is -0.4 or less, or 0.4 or greater, it indicates the balance of the bilateral brain regions of low levels and/or high levels of lateralization in both brain regions. Specifically, it is relatively easy for a doctor to judge whether the balance of the brain areas on both sides is better or worse based on the numerical values of the balance of the brain areas on both sides. However, it is more difficult to judge the balance status of both sides of the brain area between the better and worse balance status of the two sides of the brain area. The applicant found that compared with other characteristic indicators, using the brain activity of the corresponding brain areas represented by the representative wavelet amplitudes of stroke patients during upper limb movements to calculate the balance of the brain areas on both sides can be more accurate and sensitive. Reflects the recovery level of stroke patients.

Through experimental verification by the applicant, the grading levels of the balance status of both sides of the brain areas in the above preferred embodiment can more accurately and reasonably evaluate the recovery level of stroke patients. It should be noted that the boundary value of the grading level of the balance status of both sides of the brain region described in this application can be adjusted with a small deviation according to the boundary value of the above-mentioned corresponding threshold range. For example, in the balance degree of both sides of the brain region When the value is -0.16 to 0.16, it indicates a high level of balance between the two sides of the brain and/or a low level of lateralization of the two sides of the brain.

In a preferred implementation, as shown in Figure 4(c), the interface displays the balance values of the brain areas on both sides of the subject when the subject is in a resting state and an exercise state respectively. The doctor can directly obtain the balance of the brain areas on both sides. The value of the degree of balance provides the user with the balance value of the brain areas on both sides of the subject in the resting state as a reference. The user can compare the balance degree values of the brain areas on both sides of the subject in the moving state with the balance degree values of the two sides of the subject in the resting state. Balance values of lateral brain areas can be used to more accurately evaluate the recovery level of stroke patients. For example, if the balance values of both sides of the brain areas at rest are not much different from the balance values of both sides of the brain areas during exercise When this happens, the user can be reminded that it may not be objective enough to judge the patient's stroke recovery level by only using the balance values of the brain areas on both sides during exercise.

In some embodiments, a wavelet transform is performed on the acquired first blood oxygen concentration signal corresponding to the signal segment during the resting state, and the corresponding time domain-frequency domain spectrum is acquired within the preset frequency band of the wavelet transform result. Five representative amplitudes; perform wavelet transformation on the signal segment corresponding to the resting state period of the second blood oxygen concentration signal obtained, and obtain the corresponding time domain-frequency domain spectrum in the preset frequency band of the wavelet transformation result. Six representative amplitudes, the sixth representative amplitude, the fifth representative amplitude and the first and second The representative amplitude has a consistent definition; based on the fifth representative amplitude and the sixth representative amplitude, the amplitude numerical parameter in the resting state is displayed. Specifically, for example, stroke patients perform alternating tasks of 3 minutes of rest and 3 minutes of upper limb exercise. While the activity map of the wavelet transform results during upper limb movement is displayed on the map, the amplitude of the wavelet transform results during the resting state can also be displayed collaboratively for doctors' reference. For example, when the amplitude of the wavelet transformation result of the resting state deviates slightly from the reference value of the amplitude of the wavelet transformation result of the normal person's resting state (or the amplitude deviation of the wavelet transformation result during upper limb movement is small), It can remind the user that it may not be possible to objectively evaluate the recovery status of the stroke patient based only on the amplitude of the wavelet transform result of the stroke patient during upper limb movement. The amplitude numerical parameter may be the left brain region and/or the right brain region, and may be obtained, for example, by averaging the fifth representative amplitude value and/or the sixth representative amplitude value of each channel.

In one embodiment, the interval prompts of each grading level can also be displayed while displaying the value of the balance degree of the two sides of the brain area, which can make it easier for the doctor to compare the displayed value of the balance degree of the two sides of the brain area with the value of each grading level. Compare the interval ranges to more efficiently determine the balance status of the brain areas on both sides of stroke patients.

In some embodiments, the method further includes correspondingly displaying an activity map on the brain image based on the first representative amplitude and the second representative amplitude of each channel during upper limb movement. Specifically, the colors everywhere on the activity map represent the first representative amplitude (left brain area) and the second representative amplitude (right brain area) of the corresponding channel.

Secondly, while correspondingly displaying the activity map on the brain image, the third representative amplitude of the left brain area corresponding to the upper limb movement and the fourth representative amplitude of the right brain area corresponding to the upper limb movement are displayed. In some embodiments, the third representative amplitude may be obtained by averaging the first representative amplitudes of each channel, and the fourth representative amplitude may be obtained by averaging the second representative amplitudes of each channel. . For example, when calculating the balance of the two sides of the brain area, the third representative amplitude can be used as the activity of the left brain area, and the fourth representative amplitude can be used as the activity of the right brain area.

In some embodiments, the method further includes displaying the synergy of the brain regions on both sides, the synergy being obtained in the following manner: based on the first blood oxygen concentration signal corresponding to the signal segment during upper limb movement and the second blood The oxygen concentration signal corresponds to the signal segment during upper limb movement, the functional connection parameters of the brain areas on both sides are calculated, and the degree of synergy is determined based on the functional connection parameters of the brain areas on both sides. Specifically, the functional connection strength parameter can be calculated through the Pearson correlation coefficient, which will not be described in detail here.

The regional connection map shown in Figure 4(c) can display the functional connection strength of the two brain regions. The functional connection strength can reflect the activity of information transmission and cooperation efficiency between the two brain regions. by Taking the left brain area and the right brain area as an example, the functional connection strength between the two sides of the brain can be used to characterize the synergy of the two brain areas. The higher synergy of stroke patients during upper limb movements indicates that these two The information transmission activity and cooperation efficiency between brain areas are better, that is, there is a higher degree of coordination, and the level of stroke recovery is improved. When using the synergy between both sides of the brain areas to evaluate the recovery level of stroke patients, preferably, when the synergy between the two sides of the brain areas is greater than or equal to 0.37, it can indicate that the synergy between the two sides of the brain areas is high, and the synergy is high. When it is between 0.37 and 0.23, it can indicate that the degree of coordination between the two brain regions is medium. When the degree of synergy is less than or equal to 0.23, it can indicate that the degree of coordination between the two sides of the brain is low. It can be understood that the grading levels of synergy described in this application are only as preferred embodiments, and this application is not limited thereto.

In some embodiments, the channel connection map can also be presented to provide the user with detailed information on the functional connections between each channel. For example, the user can see the left brain region through the channel connection map shown in Figure 4(c) The functional connection strength between channel 5 and channel 8 in the right brain area, etc.

In addition, in another embodiment, the upper limb movement includes alternating flexion and extension movements of the upper limb while maintaining finger grip. This upper limb movement is not only simple and can reduce the difficulty of the subject's movement, but also is beneficial to corresponding brain areas. Providing sufficient stimulation is conducive to collecting more concentrated, consistent and stronger blood oxygen concentration signals for subsequent analysis. Compared with moving the fingers and simply twisting the upper arm joints, this method can be widely used for all types of stroke patients and has better differentiation between different rehabilitation levels. Patients' execution and compliance are also better; the execution of upper limb movements can be associated with exercise equipment. Defining a unified exercise method can simplify exercise equipment, reduce costs, and also help enhance the robustness of the analysis's rehabilitation level.

Figure 5 shows a schematic diagram of a stroke rehabilitation analysis system according to an embodiment of the present application. As shown in Figure 5, the stroke rehabilitation analysis system includes a near-infrared functional brain imaging device 500. The near-infrared functional brain imaging device 500 at least has a head cap 501. The head cap 501 is used to be worn on the subject's head 505. The head cap 501 Multiple probes 506 are provided for transmitting and/or receiving near-infrared signals to collect near-infrared signals of multiple corresponding channels, and thereby obtain blood oxygen concentration signals of multiple corresponding channels. For example, headgear 501 may have multiple probes 506 for transmitting and/or receiving near-infrared signals. For another example, the head cap 501 may have multiple mounting positions for detachably assembling each probe 506. During use, the probes 506 may be assembled to the head cap 501 through the mounting positions.

The complete structure of the near-infrared functional brain imaging device 500 is not shown in FIG. 5 , but only some components related to the embodiments of the present application are shown, in which each of the plurality of probes 506 can be configured to generate Emitting probe (S) or receiving probe (D), each pair of probes arranged in pairs forms a channel. In some embodiments, one transmitting probe may correspond to multiple receiving probes, or conversely, one receiving probe corresponds to multiple transmitting probes, and their pairing relationship is based on the specific layout location of the probes, the brain functional area to be detected, etc. Depends on requirements.

In some embodiments, the stroke rehabilitation analysis system also includes a processor 502, which can be separate from the near-infrared functional brain imaging device 500, and only receives the near-infrared data or blood oxygen concentration signal from it and performs further processing. , that is to say, a stroke rehabilitation analysis device may be provided, which includes a processor 502 to execute the stroke rehabilitation analysis method according to various embodiments of the present application. The processor 502 can also be integrated into the near-infrared functional brain imaging device 500 (for example, as its host), so that the near-infrared functional brain imaging device 500 provides a stroke rehabilitation analysis function, which is not limited here.

Processor 502 may be a processing device including one or more general-purpose processing devices, such as a microprocessor, a central processing unit (CPU), a graphics processing unit (GPU), or the like. More specifically, the processor may be a Complex Instruction Set Computing (CISC) microprocessor, a Reduced Instruction Set Computing (RISC) microprocessor, a Very Long Instruction Word (VLIW) microprocessor, a processor running other instruction sets, or A processor that runs a combination of instruction sets. The processor may also be one or more special purpose processing devices, such as an application specific integrated circuit (ASIC), a field programmable gate array (FPGA), a digital signal processor (DSP), a system on a chip (SoC), etc. The processor 502 may be configured to cause the plurality of probes 506 to acquire each channel of the left brain region corresponding to at least the upper limb movement when the subject performs a set of alternating tasks of upper limb movement and resting state. The first blood oxygen concentration signal, and the second blood oxygen concentration signal of each channel corresponding to at least the right brain area of the upper limb movement. Wherein, the number of groups of the alternating task, the duration of each group of upper limb movements and the duration of each group of resting states are pre-configured in association. According to the acquired first blood oxygen concentration signal and the second blood oxygen concentration signal, the analysis result in the current stroke recovery state of the subject is determined.

In some embodiments, the near-infrared functional brain imaging device 500 may also include a memory 503 and a display 504. Wherein, the memory 503 is configured to store a process that causes the processor 502 to execute the method for performing stroke rehabilitation analysis using a near-infrared brain functional imaging device as described in any embodiment herein (for example, but not limited to, performing stroke rehabilitation analysis on the acquired near-infrared signal). (Processing) procedures and data generated and/or required during execution.

The memory 503 may be a non-transitory computer-readable medium, such as read-only memory (ROM), random access memory (RAM), phase change random access memory (PRAM), static random access memory (SRAM), dynamic random access memory Access memory (DRAM), electrically erasable and programmable program read-only memory (EEPROM), other types of random access memory (RAM), flash memory or other forms of flash memory, cache, registers, static memory, compact disc read-only memory (CD-ROM), digital versatile disk (DVD ) or other optical memory, cassette tapes or other magnetic storage devices, or any other possible non-transitory medium used to store information or instructions accessible to a computer device or the like. When instructions stored on memory 503 are executed by processor 502, methods according to the description herein may be performed.

The display 504 may be configured to display the determined analysis results of the subject's current stroke recovery state, and the display 504 may adopt LED, OLED, etc., which is not specifically limited.

The near-infrared functional brain imaging device 500 itself (including the headgear and the host) according to various embodiments of the present application, or the host other than the headgear (mainly used to store and analyze near-infrared data), can be used to construct stroke rehabilitation. analysis system.

In some embodiments, the stroke rehabilitation analysis system may further include an exercise machine configured to be used by the subject to perform an array of alternating upper limb movement and rest tasks, and the processor 502 is further configured to send control information to the exercise machine. , so that the sports equipment is in an actuable state during upper limb movement and in a non-actuable state during rest. With the assistance of exercise equipment, subjects can complete the task of alternating upper limb movement and rest, further reducing the difficulty of exercise.

In some embodiments, a computer-readable storage medium has computer program instructions stored on the computer-readable storage medium. The computer program instructions, when executed by a processor, cause the processor to execute various implementations according to the present application. An example of a method for stroke rehabilitation analysis using near-infrared functional brain imaging equipment. Computer-readable media may include volatile or nonvolatile, magnetic, semiconductor-based, tape-based, optical, removable, non-removable, or other types of computer-readable media or computer-readable storage devices. For example, a computer-readable medium may be a storage device or storage module having computer instructions stored therein, as disclosed. In some embodiments, the computer-readable medium may be a disk or flash drive that has computer instructions stored thereon.

Various variations and modifications may be made to the methods, devices and systems of the present application. In view of the description and practice of the disclosed systems and related methods, other embodiments may be derived by those skilled in the art. Each claim of the present application can be understood as an independent embodiment, and any combination between them also serves as an embodiment of the present application, and these embodiments are deemed to be included in the present application.

The examples are considered to be illustrative only, with the true scope being indicated by the following claims and their equivalents.

Claims

A method for performing stroke rehabilitation analysis using a near-infrared functional brain imaging device. The near-infrared functional brain imaging device has a headgear for wearing on a subject's head. The headgear is provided with a device for transmitting and/or receiving near-infrared. Multiple probes of signals are used to collect near-infrared signals of multiple corresponding channels, and thereby obtain blood oxygen concentration signals of multiple corresponding channels, characterized in that the method includes:

In the case where the subject performs a set of alternating tasks of upper limb movement and resting state, using the plurality of probes, a first blood oxygen concentration signal of each channel of the left brain region corresponding to at least the upper limb movement is acquired, and The second blood oxygen concentration signal of each channel of the right brain area corresponding to at least the upper limb movement, wherein the number of groups of the alternating task, the duration of each group of upper limb movement and the duration of each group of resting state are associated in advance configuration;

Determine the analysis result in the current stroke recovery state of the subject according to the acquired first blood oxygen concentration signal and the second blood oxygen concentration signal; and

The results of the analysis at the determined current stroke recovery status of the subject are displayed.
The method according to claim 1, characterized in that when the duration of each group of upper limb movements and the duration of each group of resting states are pre-configured within a predetermined time range, the number of groups of the alternating tasks is pre-configured to be less than Predetermined number of groups.
The method according to claim 2, characterized in that the predetermined time range is 2 minutes to 5 minutes, and the alternating tasks are pre-configured as a single group.
The method according to claim 1, wherein the group of alternating tasks of upper limb movement and resting state includes an array of alternating tasks of upper limb movement and resting state, and the method specifically includes:

In the case where the subject performs an array of alternating tasks of upper limb movement and resting state, using the plurality of probes, several segments of the first blood oxygen concentration signal and several segments of the second blood oxygen concentration signal are acquired, wherein , the first blood oxygen concentration signal and the second blood oxygen concentration signal of each segment correspond to each group of tasks respectively;

Determine the analysis result of the subject's current stroke recovery state according to the first segments of blood oxygen concentration signals and the segments of second blood oxygen concentration signals; and

The results of the analysis at the determined current stroke recovery status of the subject are displayed.
The method according to any one of claims 1-4, characterized in that the obtained first blood oxygen concentration signal and the second blood oxygen concentration signal are several segments,

According to the segments of first blood oxygen concentration signals and the segments of second blood oxygen concentration signals, determining the analysis results of the subject's current stroke recovery state specifically includes:

According to the acquired segments of the first blood oxygen concentration signal, the acquired segments of the second blood oxygen concentration signal, and the segments of the third blood oxygen concentration signal of each channel of the peripheral brain area, the brain area of the subject is determined. Activation map, the distribution regularity of the color blocks in the activation map represents the stroke recovery level of the subject, and the first distribution regularity of the color blocks in the activation spectrum is lower than the first distribution rule of the color blocks in the activation spectrum The second distribution regularity of sex has a higher level of stroke recovery.
The method according to claim 2, characterized in that the analysis results of the subject's current stroke recovery state also include an activation map of the subject's brain area, and the distribution regularity of the color patches in the activation map represents the Said subject's stroke recovery level, the first distribution regularity of the color patches in the activation spectrum has a higher stroke recovery level than the second distribution regularity of the color patches in the activation spectrum that is lower than the first distribution regularity, The activation map includes a 2D activation map and/or a 3D activation map,

Displaying the determined analysis results of the subject's current stroke recovery state specifically includes: displaying the activation map of the subject's brain area in the first area, and displaying the activation map of the subject's brain area in a second area other than the first area. Displays the representative HbO2 distribution curve, representative HbR distribution curve and representative HbT distribution curve in the time domain.
The method according to claim 6, characterized in that the distribution regularity of the color blocks in the activation map includes the dispersion and mutation degree of the color blocks, and the higher the dispersion and mutation degree, the lower the distribution regularity.
The method according to claim 1, characterized in that the analysis results of the subject's current stroke recovery state also include stroke recovery indicators of the subject, and the stroke recovery indicators include the activity of the left brain area of the subject. degree, activity degree of right brain area;

According to the obtained first blood oxygen concentration signal and the second blood oxygen concentration signal, the analysis result of the subject's current stroke recovery state is determined, specifically including:

Determined based on the signal strength of the representative blood oxygen concentration signal of at least part of the channel in the left brain region within the first preset time window during upper limb movement and the signal strength within the second preset time window during the resting state. The activity of the subject's left brain region; and

Determined based on the signal strength of the representative blood oxygen concentration signal of at least part of the channel in the right brain region within the first preset time window during upper limb movement and the signal strength within the second preset time window during the resting state. Activity in the subject's right brain region.
The method for stroke rehabilitation analysis using a near-infrared functional brain imaging device according to claim 8, wherein the stroke rehabilitation indicators of the subject further include:

The balance between the two sides of the brain is determined based on the ratio of the difference between the activity of the left brain area and the activity of the right brain area and the sum of the activity of the left brain area and the activity of the right brain area.
The method according to any one of claims 1 to 3, characterized in that the analysis results of the subject's current stroke recovery state also include stroke recovery indicators of the subject, and the stroke recovery indicators include the subject's stroke recovery indicators. The activity of the left brain area and the activity of the right brain area;

According to the obtained first blood oxygen concentration signal and the second blood oxygen concentration signal, the analysis result of the subject's current stroke recovery state is determined, specifically including:

Perform wavelet transformation on the acquired first blood oxygen concentration signal corresponding to the signal segment during upper limb movement, and obtain the first representative amplitude in the corresponding time domain-frequency domain spectrum within the preset frequency band of the wavelet transformation result;

Perform wavelet transformation on the acquired second blood oxygen concentration signal corresponding to the signal segment during upper limb movement, and obtain the second representative amplitude in the corresponding time domain-frequency domain spectrum within the preset frequency band of the wavelet transformation result, as described a second representative amplitude having a definition consistent with said first representative amplitude;

Determine the activity of the left brain region of the subject based on the first representative amplitude of each channel of the left brain region corresponding to the upper limb movement, and based on each channel of the right brain region corresponding to the upper limb movement The second representative amplitude is used to determine the activity of the right brain region of the subject.
The method according to claim 10, characterized in that the first blood oxygen concentration signal and the second blood oxygen concentration signal are obtained when the subject performs a single set of alternating tasks of upper limb movement and resting state. , among which, the duration of upper limb movement is 2-4 minutes, and the duration of resting state is 2-4 minutes.
The method according to claim 10, characterized in that the stroke rehabilitation index of the subject further includes: based on the difference between the activity of the left brain region and the activity of the right brain region and the activity of the left brain region and the activity of the right brain region. The balance of the brain regions on both sides is determined by the ratio of the sum of regional activity levels;

The method further includes: displaying the balance degree of the brain areas on both sides.
The method according to claim 12, characterized in that the method further includes: while displaying the numerical value of the balance degree of the two sides of the brain area, prompting the grading level of the balance status of the two sides of the brain area, specifically including the following at least one of:

When the value of the balance degree of both sides of the brain area is -0.15 to 0.15, it indicates a high level of balance of the two side brain areas and/or a low level of lateralization of the two side brain areas;

When the value of the balance degree of both sides of the brain area is -0.4 to -0.15, or 0.15 to 0.4, and is not -0.4 and 0.4, it indicates that the balance degree of both sides of the brain area is at a medium level and/or both sides of the brain area moderate levels of lateralization;

When the balance value of both sides of the brain region is -0.4 or less, or 0.4 or greater, it indicates a low level of balance of the two sides of the brain region and/or a high level of lateralization of the two sides of the brain region. .
The method according to claim 10, further comprising: correspondingly displaying the activity map on the brain image based on the first representative amplitude and the second representative amplitude of each channel during upper limb movement.
The method according to claim 10 or 14, further comprising:

Perform wavelet transformation on the signal segment corresponding to the resting state period of the obtained first blood oxygen concentration signal, and obtain the fifth representative amplitude in the corresponding time domain-frequency domain spectrum within the preset frequency band of the wavelet transformation result;

Perform wavelet transformation on the signal segment corresponding to the resting state period of the second blood oxygen concentration signal obtained, and obtain the sixth representative amplitude in the corresponding time domain-frequency domain spectrum within the preset frequency band of the wavelet transformation result, The sixth representative amplitude, the fifth representative amplitude, and the first and second representative amplitudes have consistent definitions;

Based on the fifth representative amplitude and the sixth representative amplitude, an amplitude numerical parameter in a resting state is displayed.
The method according to any one of claims 10, 12 and 14, further comprising: displaying the degree of synergy of the brain regions on both sides, the degree of synergy being obtained in the following manner: based on the first blood The oxygen concentration signal corresponds to the signal segment during the movement of the upper limb and the second blood oxygen concentration signal corresponds to the signal segment during the movement of the upper limb, and the functional connection parameters of the brain areas on both sides are calculated; the functional connection parameters of the brain areas on both sides are determined according to Synergy.
The method according to any one of claims 1, wherein the upper limb movement includes alternating flexion and extension movements of the upper limb while maintaining finger grip.
A stroke rehabilitation analysis system is characterized by including:

A headgear used to be worn on a subject's head. The headgear is provided with multiple probes for transmitting and/or receiving near-infrared signals to collect near-infrared signals of multiple corresponding channels, and thereby obtain the near-infrared signals of multiple corresponding channels. Blood oxygen concentration signal;

processor, which is configured as:

In the case where the subject performs a set of alternating tasks of upper limb movement and resting state, first blood oxygen concentration signals of each channel of the left brain region corresponding to at least the upper limb movement are obtained, and at least the right blood oxygen concentration signal corresponding to the upper limb movement is obtained. The second blood oxygen concentration signal of each channel in the lateral brain area, wherein the number of groups of the alternating task, the duration of each group of upper limb movements and the duration of each group of resting states are preconfigured in association;

Determine the analysis result in the current stroke recovery state of the subject according to the acquired first blood oxygen concentration signal and the second blood oxygen concentration signal; and

A display configured to display the determined analysis results of the current stroke rehabilitation status of the subject.
A computer-readable storage medium. Computer program instructions are stored on the computer-readable storage medium. When the computer program instructions are run by a processor, the computer program instructions cause the processor to execute as described in any one of claims 1-17. Methods for stroke rehabilitation analysis using near-infrared functional brain imaging devices.