WO2023059280A1

WO2023059280A1 - Toothpaste composition with whitening feature

Info

Publication number: WO2023059280A1
Application number: PCT/TR2021/051231
Authority: WO
Inventors: Sanaz SADRY; Shanli MOTİEİ; Ramin GHATARİ
Original assignee: T.C. Istanbul Aydin Univeristesi
Priority date: 2021-10-05
Filing date: 2021-11-18
Publication date: 2023-04-13
Also published as: TR2021015502A2

Abstract

The invention relates to a toothpaste composition containing natural-vegan whitening agents with whitening properties without causing the toxic effects of chemical teeth whitening agents.

Description

TOOTHPASTE COMPOSITION WITH WHITENING FEATURE

Technical Field

The invention relates to toothpaste composition with whitening feature.

In particular, the invention relates to a toothpaste composition containing natural-vegan whitening agents with whitening properties without causing the toxic effects of chemical teeth whitening agents.

Background of the Invention

Today, teeth whitening applications are used in Aesthetic Dentistry to achieve a healthier, whiter and attractive smile.

In many studies conducted in recent years, it has been stated that most of the patients are not satisfied with the color of their teeth and they desire whiter teeth. In these studies, it has been shown that the rate of personal dissatisfaction with tooth color varies between 17.9 and 52.6% according to the population studied. This situation has also increased the demand for teeth whitening products. Although successful results are obtained with bleaching using peroxides, there are also some side effects and biological risks.

These side effects and difficulties in regulations regarding the use of whitening products have brought restrictions on the choice of this method. For this reason, it is thought that the desired aesthetic results can be obtained by using whitening toothpaste. Whitening toothpastes, in addition to the anti-caries and anti-gingivitis properties of traditional pastes, have tooth whitening properties with different active ingredients. Office whitening, also called professional whitening, was first described by M'Quillen in 1867. Then, in 1895, Pyrozone containing 25% hydrogen peroxide became the first commercially available whitening product.

Heating of hydrogen peroxide using electromagnetic radiation to increase the whitening effectiveness was first introduced in 1937 and infrared lamps were used in the 1980s in the same methodology.

Although there are many techniques for whitening vital teeth in the literature, they are all based on the use of hydrogen peroxide or its precursor carbamide peroxide.

At room temperature and pressure, hydrogen peroxide is a colorless liquid with a bitter taste, and its density is slightly higher than that of water. It is highly soluble in water and the pH of the solution becomes acid. In dentistry, hydrogen peroxide is used in teeth whitening because it produces reactive oxygen molecules. Hydrogen peroxide has strong oxidizing properties and is an unstable substance.

Generally, this compound is used in high concentration (20-40%) for in-office whitening protocols. Carbamide peroxide, on the other hand, is a white, crystalline solid compound that breaks down into hydrogen peroxide and urea; hydrogen peroxide is an active whitening agent.

Concentrations of carbamide peroxide used range from 10% to 45%, and concentrations of household agents are up to 22%. In the content of whitening gels, besides hydrogen peroxide and carbamide peroxide, sodium hydroxide, sodium perborate (materials that do not contain hydrogen peroxide), urea, thickening agents (carbapol), preservatives, excipients (glycerin), substances that reduce surface tension, sweeteners and desensitizers ( flour and potassium nitrate).

The second most common side effect during office bleaching is gingival-mucosal irritation. Since high-concentration hydrogen peroxide agent is used in office bleaching of vital teeth, this agent may cause burns when it infiltrates the gingival or mucosal tissues. Because hydrogen peroxide is a caustic agent. There are additional risks reported by in-vitro studies, such as erosion, loss of mineral teeth, greater susceptibility to demineralization, and pulp damage.

Although the whitening process has become increasingly popular, the most common side effect after whitening of vital teeth has been reported as sensitivity.

This side effect can be seen at a rate as high as 90%. The sensitivity seen after bleaching is most likely the result of the functional properties of the chemosensitive ion channel called TRPA1 (transient receptor potential ankyrin 1). This ion channel is associated with pain caused by oxidants, including hydrogen peroxide. Various studies have shown that bleaching agents also penetrate the pulp, so that bleaching produces a sensitized pulp inflammation. However, hydrogen peroxide concentration also affects tooth sensitivity. It has been reported that low-concentration agents are more easily tolerated by patients.

Toothpastes containing abrasive particles are used to remove external discolorations and prevent their recurrence. Today, these pastes often contain abrasives such as hydrated silica, calcium carbonate, dicalcium phosphate dihydrate, calcium pyrophosphate, sodium bicarbonate, perlite and alumina.

Daily use of abrasive pastes mechanically removes biofilm and chromophores, reduces adhesion and discoloration to the tooth surface. Whitening toothpastes containing oxidants and enzymes prevent discoloration by chemically changing the pigments that color the teeth. Optical whitening toothpastes are effective thanks to their pigment content such as "blue covarin".

After brushing, a blue, thin, semi-transparent film layer accumulates on the tooth surface. With this thin film layer and the interaction of light, the teeth appear whiter and brighter. Recently, whitening toothpastes containing activated carbon are also frequently used.

The charcoal in toothpastes available today is typically a fine powder form of activated charcoal that is oxidized by controlled reheating or chemical means. There are products containing fluoride, as well as whitening toothpastes containing active carbon that do not contain fluoride. The inactivating effect of charcoal, which is a well-known absorption agent, on fluoride and its caries-preventing effect need to be investigated. There are few studies evaluating the effectiveness of toothpastes containing activated carbon.

In the literature, in the US patent application numbered US2019167558A1 regarding the subject, " Formulations for oral care products that incorporate coconut oil for effectively removing bacteria from the mouth and methods for making these products are disclosed herein." statements are included.

In said application, a toothpaste embodiment comprising coconut oil is disclosed.

Again, in the PCT application numbered W02019104033A1 in the literature, regarding the subject, “Natural toothpastes according to embodiments of the present technology may include water in an amount less than about 60% by weight of the natural toothpaste. The natural toothpaste may include clay in an amount between about 20% and about 60% by weight of the natural toothpaste. The toothpaste may include coconut oil in an amount less than or about 10% by weight of the natural toothpaste. The toothpaste may include sodium chloride in an amount less than or about 2% by weight of the natural toothpaste. The toothpaste may include fulvic acid in an amount less than or about 0.5% by weight of the natural toothpaste. The toothpaste may also include coenzyme Q10.” statements are included.

Also in the literature, in the US patent application numbered US2021113439A1 regarding the subject, “The present invention relates to toothpaste compositions for oral care, and more particularly relates to natural Fluoride-free toothpaste composition. The natural fluoride-free oral care composition comprises of charcoal, coconut oil, baking soda, natural sweetener such as stevia powder, peppermint, cinnamon, and myrrh. In the present composition, peppermint, cinnamon, and myrrh exhibit synergistic antioxidant activity with better potential effects than other commercial toothpastes available in the market. The activated charcoal provides higher adsorptive strength and makes it capable of removing all unnecessary tooth surface adhesive substances.” statements are included.

Due to the disadvantages mentioned above, it was necessary to introduce a new toothpaste composition with whitening feature.

Disclosure of the Invention

Starting from this position of the technique, the aim of the invention is to present a new toothpaste structure with whitening feature that eliminates the existing disadvantages.

Another object of the invention is to provide a toothpaste embodiment with antimicrobial activity.

Another aim of the invention is to provide a structure that does not cause the toxic effects of chemical teeth whitening agents.

Another aim of the invention is to provide a structure that allows the mouth to be cleaned by absorbing the toxins in the mouth.

Another aim of the invention is to reveal a structure that kills bacteria in the tongue and gums in the mouth.

Another aim of the invention is to provide a structure that is used for whitening and does not increase the sensitivity of teeth compared to other products consisting of chemicals.

Another aim of the invention is to provide a structure that not only prevents plaque formation but also protects gingival health.

Another aim of the invention is to reveal a structure that prevents bad breath and tooth decay by showing antibacterial, antifungal and antiviral activity. Another aim of the invention is to present a structure that heals the gums, prevents heart disease and supports the immune system.

Another aim of the invention is to reveal a structure that strengthens the gingiva and jaw by improving acne.

Detailed Description of the Invention

In this detailed explanation, the innovation that is the subject of the invention is only explained with examples that will not have any limiting effect for a better understanding of the subject.

The invention is a toothpaste composition that contains natural whitening agents without causing the toxic effects caused by chemical teeth whitening agents, characterized in that; comprises 10 - 13 grams of coconut oil, 1.5 - 3.5 grams of beeswax, 0.25 - 1.25 grams of avocado oil, 0.5 - 0.20 grams of Eucalyptus oil, 0.5 - 0.20 grams of orange oil.

The mentioned toothpaste composition consists of the main components of 10 - 13 grams of coconut oil, 1.5 - 3.5 grams of beeswax, 0.25 - 1 .25 grams of avocado oil, 0.5 - 0.20 grams of Eucalyptus oil, 0.5 - 0.20 grams of orange oil and 0.5 - 0.20 grams of lavender oil.

The whitening toothpaste structure, which is the subject of the invention, contains 11.55 grams of coconut oil, 2.25 grams of beeswax, 0.75 grams of avocado oil, 0.15 grams of Eucalyptus oil, 0.15 grams of orange oil and 0.15 grams of lavender oil in preferred proportions.

Coconut oil:

Coconut oil should touch the teeth, gums and tongue to absorb toxins in the mouth and clean the mouth. Killing bacteria in the mouth thanks to the ingredients of coconut oil. At the same time, these substances also destroy bacteria in the tongue and gums. Coconut oil does not increase the sensitivity of your teeth compared to other whitening and chemical products. It also prevents the formation of plaque and protects your gum health. Lauric acid, which is abundant in coconut, shows antibacterial, antifungal and antiviral activity, therefore it prevents bad breath. It prevents and heals tooth decay. Bad breath kills.

It heals the gums.

It prevents heart disease.

It reduces inflammation.

It whitens teeth.

Improves throat dryness.

Prevents and heals wounds.

It softens the lips.

It supports the immune system.

It improves acne.

Strengthens the gums and jaw.

Beeswax:

Honey significantly reduces the amount of acid produced by Streptococcus mitis, Streptococcus Sabrinus and Lactobacillus casii, which are bacteria responsible for dental caries. Based on this, it was concluded that beeswax also provides a positive benefit in healing gingival wounds, thanks to its anti-inflammatory components, its ability to reduce swelling and pain and help whiten teeth.

Honey, which contains many amino acids, vitamins and other elements, is on the list of natural foods that most support cell and tissue production. In addition, beeswax ensures that a large part of the amount of calcium and magnesium taken into the body is absorbed. This is especially good for the development of bone structure and tooth structures and tooth enamel whitening.

For this reason, it is recommended to eat a teaspoon of honey in addition to foods such as milk and almonds, which are rich in calcium and magnesium, in order to increase oral health and protect the strength of tooth structures. Avocado oil:

Contains vitamins A, B3, C, D and E.

It is an important source of antioxidants. It strengthens immunity.

Avocado oil, which is an intense source of antioxidants and frequently preferred by individuals who eat healthy, is a great protection shield especially against gingival recession.

Avocado oil also helps prevent gum recession. While gum recession causes bleeding in the teeth, intense pain, redness and bad breath, if precautions are not taken, even tooth extraction may occur. According to studies, it has been observed that thanks to the IL1 B content of Avocado oil, it stops the synthesis of the protein that causes bone loss in gingival recessions.

Lavender oil:

Lavender flower; It is a drug that has been used in folk medicine for a long time due to its effects such as diuretic, diaphoretic, stimulant, relieving rheumatic pains, antiseptic, expectorant, relieving urinary tract inflammation, healing eczema wounds, strengthening nerve and heart.

Essential oils are natural compounds preferred by people because they prevent postharvest losses and are not harmful to human health. (Vergis et al., 2015). Essential oils, which are among the edible coatings, are found in aromatic plants. In addition, essential oils have an important role in plants with their antibacterial, antiviral, antifungal and insecticidal functions.

Eucalyptus oil:

Eucalyptus oil, which prevents multiple problems such as dental infections, gingivitis and refreshing effect, also allows the healing of existing inflammations.

Orange oil: Orange oil contains rich vitamin C, has antiseptic, aphrodisiac, antispasmodic, antiinflammatory and carminative, sedative and antidepressant properties. Orange oils, which can be both sweet and bitter, have health-promoting and gum-healing properties.

Orange has an intense fresh fruit, citrus scent, both as a fruit and as an oil. This scent also has a calming and refreshing effect on the person. Since orange oil has antiseptic properties, it prevents the living and spreading of microbes and bacteria. In this respect, it especially heals gums, mouth tissue and throat wounds.

At first, 11.55 grams of coconut oil, 0.75 grams of avocado oil, 0.15 grams of Eucalyptus oil, 0.15 grams of orange oil and 0.15 grams of lavender oil are brought together and mixed at 50 °C and the oil rates and density of the oils are balanced. While continuing to mix, the wax is added and melted. All these processes are done within 20 minutes.

After the wax has completely melted, it is expected that we will continue to stir and the substance we have obtained will go from liquid to solid at room temperature.

Claims

CLAIMS The invention is a toothpaste composition that contains natural whitening agents without causing the toxic effects caused by chemical teeth whitening agents, characterized in that; comprises 10 - 13 grams of coconut oil, 1.5 - 3.5 grams of beeswax, 0.25 - 1 .25 grams of avocado oil, 0.5 - 0.20 grams of Eucalyptus oil, 0.5 - 0.20 grams of orange oil. A toothpaste composition with a whitening feature according to claim 1 ; it contains 0.5 - 0.20 grams of lavender oil. A toothpaste composition with a whitening according to any preceding claims; contains 11.55 grams of coconut oil, 2.25 grams of beeswax, 0.75 grams of avocado oil, 0.15 grams of Eucalyptus oil, 0.15 grams of orange oil. A toothpaste composition with a whitening according to any preceding claims; contains 0.15 grams of lavender oil.