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WO2022268520A1 - Use of substituted pyrrolidinones or their salts for increasing stress tolerance of plants - Google Patents

Use of substituted pyrrolidinones or their salts for increasing stress tolerance of plants Download PDF

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Publication number
WO2022268520A1
WO2022268520A1 PCT/EP2022/065728 EP2022065728W WO2022268520A1 WO 2022268520 A1 WO2022268520 A1 WO 2022268520A1 EP 2022065728 W EP2022065728 W EP 2022065728W WO 2022268520 A1 WO2022268520 A1 WO 2022268520A1
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alkyl
aryl
heteroaryl
heterocyclyl
cycloalkyl
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PCT/EP2022/065728
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German (de)
French (fr)
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Jens Frackenpohl
Lars ARVE
Hendrik Helmke
Birgit Kuhn
Jana Schmidt
Jan Dittgen
Dirk Schmutzler
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Bayer Aktiengesellschaft
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/46—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P21/00—Plant growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Definitions

  • Bayer AG Use of substituted pyrrolidinones or their salts to increase stress tolerance in plants.
  • Description The invention relates to the use of substituted pyrrolidinones or salts thereof to increase the stress tolerance in plants to abiotic stress and to increase plant growth and/or to increase plant yield.
  • certain substituted pyrrolidin-2-one-4-carboxamides and pyrrolidin-2-one-4-acetic acid amides can be used as active pharmaceutical ingredients, e.g. B. as beta-secretase inhibitors (cf. e.g. WO2009/038412) or as P2X7 modulators for the treatment of inflammatory and neurodegenerative diseases (cf. e.g.
  • Selected pyrrolidinone-substituted ureas are described as lead structures for identifying TRPV1 modulators (cf. Future Med. Chem.2015, 7, 243) or ERK inhibitors (cf. WO2016/100050).
  • TRPV1 modulators cf. Future Med. Chem.2015, 7, 243
  • ERK inhibitors cf. WO2016/100050.
  • the use of certain pyrrolidin-2-one-4-carboxamides as lead structures for identifying antituberculosis drugs or G protein-coupled receptor kinase inhibitors has also been described (Bioorg. Med. Chem.2010, 18, 6914; Bioorg. Med. Chem. Lett. 2018, 28, 1507).
  • N-sulfonyl-aminoacetonitriles can be used to control parasites in warm-blooded animals (see WO2004/000798).
  • the use of 1-(4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4- tetrahydroquinolin-6-yl)methanesulfonamide against drought stress in Arabidopsis thaliana and soya is described in Proc. national Acad. Sci. 2013, 110(29), 12132-12137.
  • WO2013/148339 also claims (2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamides with unsubstituted N-cycloalkyl radicals, while WO2015/155154 examines the effect of specially substituted (2-oxo-1, 2,3,4-tetrahydroquinolin-6-yl)methanesulfonamides against abiotic stress and the agonistic effect of the substances in question on abscisic acid receptors is described. WO2015/049351 describes the effect of dihydrooxindolylsulfonamides against abiotic stress in plants.
  • abiotic stresses eg cold, heat, drought, salt, flooding.
  • Some of these belong to signal transduction chains (eg transcription factors, kinases, phosphatases) or cause a physiological response in the plant cell (eg ion transport, detoxification of reactive oxygen species).
  • the signal chain genes of the abiotic stress response include, inter alia, transcription factors of the classes DREB and CBF (Jaglo-Ottosen et al., 1998, Science 280: 104-106).
  • ATPK and MP2C type phosphatases are involved in the response to salt stress.
  • salt stress often activates the biosynthesis of osmolytes such as proline or sucrose.
  • Sucrose synthase and proline transporters are involved here (Hasegawa et al., 2000, Annu Rev Plant Physiol Plant Mol Biol 51: 463-499).
  • the plants' defense against stress against cold and drought partly uses the same molecular mechanisms.
  • the accumulation of so-called Late Embryogenesis Abundant Proteins (LEA proteins) is known, to which the dehydrins belong as an important class (Ingram and Bartels, 1996, Annu Rev Plant Physiol Plant Mol Biol 47: 277-403, Close, 1997, Physiol Plants 100: 291-296).
  • LSA proteins Late Embryogenesis Abundant Proteins
  • naphthylsulfonamide (4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide) affects the germination of plant seeds in the same way as abscisic acid (Park et al. Science 2009, 324, 1068-1071).
  • a naphthylsulfamidocarboxylic acid (N-[(4-bromo-1-naphthyl)sulfonyl]-5-methoxynorvaline) shows a mode of action in biochemical receptor tests that is comparable to 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide is comparable (Melcher et al. Nature Structural & Molecular Biology 2010, 17, 1102-1108).
  • antioxidants such as naphthols and xanthines
  • DD 277832 the molecular causes of the anti-stress effect of these substances are largely unknown.
  • PARP poly-ADP-ribose polymerases
  • PARG poly-(ADP-ribose) glycohydrolases
  • tolerance to abiotic stress is understood to mean, for example, tolerance to cold, heat, drought stress (stress caused by drought and/or lack of water), salts and flooding.
  • substituted pyrrolidinones can be used to increase the stress tolerance in plants to abiotic stress and to increase plant growth and/or to increase plant yield.
  • R 1 is hydrogen, NR 30 R 31 , OR 32 , S(O) m R 33 , (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )- Alkynyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 )haloalkenyl, (C 2 -C 8 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )halocycloalkenyl, aryl, aryl-(C 1
  • R 30 and R 31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted,
  • R 32 is hydrogen, (C 1 -C 8 )- alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkyl, (C 2 -C 8 )alkynyloxycarbonyl-(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 )- alkyl, heteroaryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, heterocyclyl-(C 1 -C 8 ) -alkoxycarbonyl-(C1-C8)-alkyl , or R
  • R 34 is hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, aryl-(C 1 -C 8 )alkyl, aryl, heteroaryl, heteroaryl-(C C 1 -C 8 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-alkyl, R 30 R 31 N-(C 1 -C 8 )- alkyl, NR 30 R 31 , (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, S(O)mR 33 represents, R 35 represents hydrogen, NR 30 R 31 , OR 32 , (C C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, aryl, aryl
  • the compounds of general formula (I) can be synthesized by addition of a suitable inorganic or organic acid, such as mineral acids such as HCl, HBr, H 2 SO 4 , H 3 PO 4 or HNO 3 , or organic acids, eg. B. carboxylic acids such as formic acid, acetic acid, propionic acid, oxalic acid, lactic acid or salicylic acid or sulfonic acids such as p-toluenesulfonic acid to a basic group such as amino, alkylamino, dialkylamino, piperidino, morpholino or pyridino. These salts then contain the conjugate base of the acid as an anion.
  • a suitable inorganic or organic acid such as mineral acids such as HCl, HBr, H 2 SO 4 , H 3 PO 4 or HNO 3
  • organic acids eg. B.
  • carboxylic acids such as formic acid, acetic acid, propionic acid, oxalic acid
  • Suitable substituents which are in deprotonated form can form inner salts with groups which in turn can be protonated, such as amino groups. Salt formation can also take place by the action of a base on compounds of the general formula (I).
  • Suitable bases are, for example, organic amines such as trialkylamines, morpholine, piperidine and pyridine and ammonium, alkali or alkaline earth metal hydroxides, carbonates and bicarbonates, in particular sodium and potassium hydroxide, sodium and potassium carbonate and sodium and potassium bicarbonate.
  • salts are compounds in which the acidic hydrogen is replaced by an agriculturally suitable cation, for example metal salts, in particular alkali metal salts or alkaline earth metal salts, in particular sodium and potassium salts, or else ammonium salts, salts with organic amines or quaternary ammonium salts, for example with cations of the formula [NR a R b R c R d ] + , in which R a to R d each independently represent an organic radical, in particular alkyl, aryl, aralkyl or alkylaryl.
  • an agriculturally suitable cation for example metal salts, in particular alkali metal salts or alkaline earth metal salts, in particular sodium and potassium salts, or else ammonium salts, salts with organic amines or quaternary ammonium salts, for example with cations of the formula [NR a R b R c R d ] + , in which R a to R d each independently represent an organic radical, in particular al
  • alkylsulfonium and alkylsulfoxonium salts such as (C 1 -C 4 )-trialkylsulfonium and (C 1 -C 4 )-trialkylsulfoxonium salts.
  • alkylsulfonium and alkylsulfoxonium salts such as (C 1 -C 4 )-trialkylsulfonium and (C 1 -C 4 )-trialkylsulfoxonium salts.
  • a preferred subject of the invention is the use of compounds of the general formula (I) in which R 1 is hydrogen, NR 30 R 31 , OR 32 , S(O)mR 33 , (C 1 -C 7 )-alkyl, (C 2 -C 7 )alkenyl, (C 2 -C 7 )alkynyl, (C 1 -C 7 )haloalkyl, (C 2 -C 7 )haloalkenyl, (C 2 -C 7 )haloalkynyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )halocycloalkyl, (C 4 -C 7 )cycloalkenyl, (C 4 -C 7 )halocycloalkenyl, aryl, aryl(C 1 -C 7 )alkyl, heteroaryl , heteroaryl(C 1 -C 7 )alkyl, heterocyclyl, heterocyclyl(C
  • C 7 )alkyl (C 1 -C 7 )alkoxy-(C 1 -C 7 )alkoxy-(C 1 -C 7 )alkoxy-(C 1 -C 7 )alkyl, (C 1 -C 7 )- alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, aryl, aryl-( C 1 -C 7 )alkyl, aryl(C 1 -C 7 )alkoxy(C 1 -C 7 )alkyl, heteroaryl, heteroaryl(C 1 -C 7 )alkyl, (C 3 -C 7 )cycloalkyl(C 1 -C 7 )alkyl, (C 4 -C 7 )cycloalkenyl(C 1 -C 7 )alkyl, bis
  • R 34 is hydrogen, (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, aryl-(C 1 -C 7 )alkyl, aryl, heteroaryl, heteroaryl-(C C 1 -C 7 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-alkyl, R 30 R 31 N-(C 1 -C 7 )- alkyl, NR 30 R 31 , (C 3 -C 7 )cycloalkyl-(C 1 -C 7 )alkyl, S(O) m R 33 , R 35 is hydrogen, NR 30 R 31 , OR 32 , (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, (C 2 -C 7 )alkynyl, aryl, aryl
  • a particularly preferred subject of the invention is the use of compounds of the general formula (I) in which R 1 is hydrogen, NR 30 R 31 , OR 32 , S(O) m R 33 , (C 1 -C 6 )-alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloalkenyl, (C 2 -C 6 )haloalkynyl, (C 3 -C 6 cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 )halocycloalkenyl, aryl, aryl-(C 1 -C 6 )alkyl , heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl, heterocycl
  • N-morpholinyl R 34 for hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, aryl-(C 1 -C 6 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-alkyl, R 30 R 31 N-(C 1 -C 6 )-alkyl, NO 30 R 31 , (C 3 -C 6 )-cycloalkyl-(C 1 -C 6 )-alkyl, S(O) m R 33 stands, R 35 for hydrogen, NO 30 R 31 , OR 32 , (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, ary
  • a very particularly preferred subject of the invention is the use of compounds of the general formula (I) in which R 1 for hydrogen, NO 30 R 31 , OR 32 , S(O) m R 33 , (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 1 -C 6 )-haloalkyl, (C 2 -C 6 )-haloalkenyl, (C 2 -C 6 )-haloalkynyl, (C 3 -C 6 )-cycloalkyl, (C 3 -C 6 )-halocycloalkyl, (C 4 -C 6 )-cycloalkenyl, (C 4 -C 6 )-halocycloalkenyl, aryl, aryl-(C 1 -C 6 )-alkyl, heteroaryl, heteroaryl-(C 1 -C 6 )-al
  • N-morpholinyl R 34 for hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, aryl-(C 1 -C 6 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-alkyl, R 30 R 31 N-(C 1 -C 6 )-alkyl, NO 30 R 31 , (C 3 -C 6 )-cycloalkyl-(C 1 -C 6 )-alkyl, S(O) m R 33 stands, R 35 for hydrogen, NO 30 R 31 , OR 32 , (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, ary
  • a particularly preferred subject of the invention is the use of the following compounds described by general formula (I): 2-[1-[(3-chloro-2-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[ 1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamide, 2-[1- [(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1 -methyl-1H-tetrazol-5-yl)acetamide, (2S,3S)-2-[[2-[(2S)-1-[(2,3- difluorophenyl)methyl]-5-ox
  • substituted N-pyrrolidinones of the general formula (I) are also not yet known in the prior art.
  • substituted N-pyrrolidinones of the general formula (I) or their salts apply, wherein R 1 for (C 1 -C 8th )-alkyl, (C 2 -C 8th )-alkenyl, (C 2 -C 8th )-alkynyl, (C 1 -C 10 )-haloalkyl, (C 3 -C 10 )-cycloalkyl, (C 3 -C 10 )-halocycloalkyl, (C 4 -C 10 )-cycloalkenyl, aryl, aryl-(C 1 -C 8th )-alkyl, heteroaryl, heteroaryl-(C 1 -C 8th )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8th )-alkyl-alkyl-alkyl, heterocycly
  • substituted N-pyrrolidinones of the general formula (I) or their salts apply, wherein R 1 for (3-methylphenyl)methyl, (4-methylphenyl)methyl, (2-methylphenyl)methyl, (3-trifluoromethylphenyl)methyl, (4-trifluoroethylphenyl)methyl, (2-trifluoromethylphenyl)methyl, (3-chlorophenyl)methyl, (4-chlorophenyl)methyl, (3-fluorophenyl)methyl, (4-fluorophenyl)methyl, (2-fluorophenyl)methyl, (3,4-difluorophenyl)methyl, (3,4-dichlorophenyl)methyl, (3-fluoro -4-chlorophenyl)methyl, (3-chloro-4-fluorophen
  • R 7 R represents hydrogen 3 , R 4 independently for hydrogen, (C 1 -C 8th )-alkyl, (C 1 -C 10 )-haloalkyl, (C 3 -C 10 )-cycloalkyl, aryl-(C 1 -C 8th )-alkyl, aryl, R 5 , R 6 independently for hydrogen, (C 1 -C 8th )-alkyl, (C 2 -C 8th )-alkenyl, (C 1 -C 10 )-haloalkyl, (C 3 -C 10 )-cycloalkyl, aryl-(C 1 -C 8th )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 8th )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8th )-alkyl, R 32 O-(C 1 -C 8th )-alkyl, R 30 R 31 N-(
  • R 35 for hydrogen, NO 30 R 31 , OR 32 , (C 1 -C 8th )-alkyl, (C 2 -C 8th )-alkenyl, (C 2 -C 8th )-alkynyl, aryl, aryl-(C 1 -C 8th )-alkyl, heteroaryl, heteroaryl-(C 1 -C 8th )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8th )-alkyl, R 32 O-(C 1 -C 8th )-alkyl, (C 3 -C 10 )-cycloalkyl, (C 3 -C 10 )-cycloalkyl-(C 1 -C 8th )-alkyl, S(O) m R 33 , R 32 (O )C-(C 1 -C 8th )-alkyl, R 32 O(O)C-(C 1 -C 8th )-alkyl
  • R 7 R represents hydrogen 3 , R 4 independently for hydrogen, (C 1 -C 7 )-alkyl, (C 1 -C 7 )-haloalkyl, (C 3 -C 7 )-cycloalkyl, aryl-(C 1 -C 7 )-alkyl, aryl, R 5 , R 6 independently for hydrogen, (C 1 -C 7 )-alkyl, (C 2 -C 7 )-alkenyl, (C 1 -C 7 )-haloalkyl, (C 3 -C 7 )-cycloalkyl, aryl-(C 1 -C 7 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 7 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-alkyl, R 30 R 31 N-(C 1 -C 7 )
  • R 35 for hydrogen, NO 30 R 31 , OR 32 , (C 1 -C 7 )-alkyl, (C 2 -C 7 )-alkenyl, (C 2 -C 7 )-alkynyl, aryl, aryl-(C 1 -C 7 )-alkyl, heteroaryl, heteroaryl-(C 1 -C 7 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-cycloalkyl, (C 3 -C 7 )-cycloalkyl-(C 1 -C 7 )-alkyl, S(O)mR 33 , R 32 (O )C-(C 1 -C 7 )-alkyl, R 32 O(O)C-(C 1 -C 7 )-alkyl, R 30 R
  • N-morpholinyl, R 35 for hydrogen, NO 30 R 31 , OR 32 , (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, aryl, aryl-(C 1 -C 6 )-alkyl, heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-cycloalkyl, (C 3 -C 6 )-cycloalkyl-(C 1 -C 6 )-alkyl, S(O)mR 33 , R 32 (O )C-(C 1 -C 6 )-alkyl, R 32 O(O)C-(C 1 -C 6 )-alkyl, R 30 R
  • the following compounds of the general formula (I) are particularly preferred: 4-[2-[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]oxyethoxy]benzoic acid, 2-( 4-formylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, (2R)-2-[[2-[1-[(4-methylphenyl)methyl] -5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylsulfanylbutyric acid, 2-(4-ethylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-(4-methylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]
  • radicals given above in general or in preferred ranges apply both to the end products of the formula (I) and correspondingly to the starting materials or intermediates required in each case for the preparation. These radical definitions can be combined with one another as desired, ie also between the specified preferred ranges.
  • compounds of the formula (I) according to the invention or their salts or their use according to the invention are of particular interest, in which individual radicals have one of the preferred meanings already mentioned or mentioned below, or in particular those in which one or more of the preferred meanings already mentioned or mentioned below occur in combination.
  • the designations used above and below are explained.
  • heterocyclyl- (C 1 -C 8th )-alkyl or R 32 O(O)C-(C 1 -C 8th )-alkyl the term “alkyl” therefore also stands for an alkylene group.
  • alkylsulfonyl alone or as part of a chemical group - represents straight-chain or branched alkylsulfonyl, preferably having 1 to 8, or having 1 to 6 carbon atoms, e.g.
  • (but not limited to) (C 1 -C 6 )-alkylsulfonyl such as methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methylpropylsulfonyl, 1,1-dimethylethylsulfonyl, pentylsulfonyl, 1-methylbutylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, 1,1-dimethylpropylsulfonyl, 1,2-dimethylpropylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylpropylsulfonyl, hexylsulfonyl, 1-methylpentylsulfonyl
  • heteroarylsulfonyl represents optionally substituted pyridylsulfonyl, pyrimidinylsulfonyl, pyrazinylsulfonyl or optionally substituted polycyclic heteroarylsulfonyl, here in particular optionally substituted quinolinylsulfonyl, for example substituted by fluorine, chlorine, bromine, iodine, cyano, nitro, alkyl, haloalkyl, haloalkoxy, amino -, alkylamino, alkylcarbonylamino, dialkylamino or alkoxy groups.
  • alkylthio on its own or as part of a chemical group—is straight-chain or branched S-alkyl, preferably having 1 to 8 or 1 to 6 carbon atoms, such as (C 1 -C 10 )-, (C 1 -C 6 )- or (C 1 -C 4 )-alkylthio, e.g.
  • alkenylthio means an alkenyl radical bonded via a sulfur atom
  • alkynylthio means an alkynyl radical bonded via a sulfur atom
  • cycloalkylthio means a cycloalkyl radical bonded via a sulfur atom
  • cycloalkenylthio means a cycloalkenyl radical bonded via a sulfur atom
  • (but not limited to) (C 1 -C 6 )-alkylsulphinyl such as methylsulphinyl, ethylsulphinyl, propylsulphinyl, 1-methylethylsulphinyl, butylsulphinyl, 1-methylpropylsulphinyl, 2-methylpropylsulphinyl, 1,1-dimethylethylsulphinyl, pentylsulphinyl, 1-methylbutylsulphinyl, 2-methylbutylsulphinyl, 3-methylbutylsulphinyl, 1,1-dimethylpropylsulphinyl, 1,2-dimethylpropylsulphinyl, 2,2-dimethylpropylsulphinyl, 1-ethylpropylsulphinyl, hexylsulphinyl, 1-methylpentylsulphinyl, 2-methylpentylsulphinyl, 3-methylpentyl
  • Alkoxy means an alkyl radical bonded through an oxygen atom, e.g. B.
  • (but not limited to) (C 1 -C 6 )-Alkoxy such as methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1-dimethylethoxy, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1, 3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl- 1-methyl-propoxy and 1-ethyl-2-methylpropoxy.
  • Alkenyloxy means an alkenyl radical bonded via an oxygen atom
  • alkynyloxy means an alkynyl radical bonded via an oxygen atom such as (C 2 -C 10 )-, (C 2 -C 6 )- or (C 2 -C 4 )-alkenoxy or (C 3 -C 10 )-, (C 3 -C 6 )- or (C 3 -C 4 )-alkynoxy.
  • Cycloalkyloxy means an oxygen-bonded cycloalkyl radical and cycloalkenyloxy means an oxygen-bonded cycloalkenyl radical.
  • the number of carbon atoms refers to the alkyl radical in the alkylcarbonyl group.
  • the number of carbon atoms refers to the alkenyl or alkynyl radical in the alkenyl or alkynylcarbonyl group.
  • the number of carbon atoms refers to the alkyl radical in the alkoxycarbonyl group.
  • alkenyloxycarbonyl and “alkynyloxycarbonyl”, unless otherwise defined elsewhere, stand for alkenyl or alkynyl radicals which are bonded to the skeleton via —O—C( O)—, such as (C 2 -C 10 )-, (C 2 -C 6 )- or (C 2 -C 4 )-alkenyloxycarbonyl or (C 3 -C 10 )-, (C 3 -C 6 )- or (C 3 -C 4 )- alkynyloxycarbonyl.
  • the number of carbon atoms refers to the alkenyl or alkynyl radical in the alkene or alkynyloxycarbonyl group.
  • the number of carbon atoms refers to the alkyl radical in the alkylcarbonyloxy group.
  • the number of carbon atoms refers to the alkenyl or alkynyl radical in the alkenyl or alkynylcarbonyloxy group.
  • C(O)R 12 , C(O)OR 12 , OC(O)NO 10 R 11 , or C(O)NO 10 R 11 the abbreviation O given in brackets stands for an oxygen atom bonded to the adjacent carbon atom via a double bond.
  • OC(S)OR 12 , OC(S)SR 13 , OC(S)NO 10 R 11 the abbreviation S given in brackets stands for a sulfur atom bonded to the neighboring carbon atom via a double bond.
  • aryl means an optionally substituted mono-, bi- or polycyclic aromatic system having preferably 6 to 14, in particular 6 to 10, ring carbon atoms, for example phenyl, naphthyl, anthryl, phenanthrenyl and the like, preferably phenyl.
  • optionally substituted aryl also includes polycyclic systems such as tetrahydronaphthyl, indenyl, indanyl, fluorenyl and biphenylyl, the binding site being on the aromatic system. Systematically, “aryl” is generally also included in the term “optionally substituted phenyl”.
  • Preferred aryl substituents here are, for example, hydrogen, halogen, alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, halocycloalkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkoxyalkyl, alkylthio, haloalkylthio, haloalkyl, alkoxy, Haloalkoxy, cycloalkoxy, cycloalkylalkoxy, aryloxy, heteroaryloxy, alkoxyalkoxy, alkynylalkoxy, alkenyloxy, bis-alkylaminoalkoxy, tris-[alkyl]silyl, bis-[alkyl]arylsilyl, bis-[alkyl]alkylsilyl, tris-[
  • heterocyclyl radical or heterocyclic ring When the heterocyclyl radical or heterocyclic ring is optionally substituted, it may be fused to other carbocyclic or heterocyclic rings.
  • polycyclic systems are also included, such as, for example, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[2.2.2]octanyl or 1-azabicyclo[2.2.1]heptyl.
  • spirocyclic systems are also included, such as 1-oxa-5-azaspiro[2.3]hexyl.
  • the heterocyclic ring preferably contains 3 to 9 ring atoms, in particular 3 to 6 ring atoms, and one or more, preferably 1 to 4, in particular 1, 2 or 3 heteroatoms im heterocyclic ring, preferably from the group N, O, and S, but not two oxygen atoms should be directly adjacent, such as with a heteroatom from the group N, O and S 1- or 2- or 3-pyrrolidinyl, 3,4 -dihydro-2H-pyrrol-2- or 3-yl, 2,3-dihydro-1H-pyrrol-1- or 2- or 3- or 4- or 5-yl; 2,5-dihydro-1H-pyrrole-1- or 2- or 3-yl, 1- or 2- or 3- or 4-piperidinyl; 2,3,4,5-tetrahydropyridin-2- or 3- or 4- or 5-yl or 6-yl; 1,2,3,6-tetrahydropyridin-1- or 2- or 3- or 4- or 5- or 6-yl; 1,2,3,4-tetrahydr; 1,2,3,
  • 3-ring and 4-ring heterocycles are 1- or 2-aziridinyl, oxiranyl, thiiranyl, 1- or 2- or 3-azetidinyl, 2- or 3-oxetanyl, 2- or 3-thietanyl, 1,3 -dioxetan-2-yl.
  • heterocyclyl are a partially or fully hydrogenated heterocyclic radical having two heteroatoms from the group N, O and S, such as 1- or 2- or 3- or 4-pyrazolidinyl; 4,5-dihydro-3H-pyrazol-3- or 4- or 5-yl; 4,5-dihydro-1H-pyrazol-1- or 3- or 4- or 5-yl; 2,3-dihydro-1H-pyrazol-1- or 2- or 3- or 4- or 5-yl; 1- or 2- or 3- or 4-imidazolidinyl; 2,3-dihydro-1H-imidazole-1- or 2- or 3- or 4-yl; 2,5-dihydro-1H-imidazol-1- or 2- or 4- or 5-yl; 4,5-dihydro-1H-imidazol-1- or 2- or 4- or 5-yl; hexahydropyridazin-1- or 2- or 3- or 4-yl; 1,2,3,4-tetrahydropyridazin-1- or
  • heterocyclyl are a partially or fully hydrogenated heterocyclic radical with 3 heteroatoms from the group N, O and S, such as 1,4,2-dioxazolidin-2- or 3- or 5-yl; 1,4,2-dioxazol-3- or 5-yl; 1,4,2-dioxazinan-2- or -3- or 5- or 6-yl; 5,6-dihydro-1,4,2-dioxazin-3- or 5- or 6-yl; 1,4,2-dioxazin-3- or 5- or 6-yl; 1,4,2-dioxazepan-2- or 3- or 5- or 6- or 7-yl; 6,7-dihydro-5H-1,4,2-dioxazepin-3- or 5- or 6- or 7-yl; 2,3-dihydro-7H-1,4,2-dioxazepine-2- or 3- or 5- or 6- or 7-yl; 2,3-dihydro-5H-1,4,2-dioxazepine-2- or 3- or 5- or 6-
  • heterocycles listed above are preferably substituted, for example, by hydrogen, halogen, alkyl, haloalkyl, hydroxy, alkoxy, cycloalkoxy, aryloxy, alkoxyalkyl, alkoxyalkoxy, cycloalkyl, halocycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclyl, alkenyl, alkylcarbonyl, cycloalkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, Alkoxycarbonyl, Hydroxycarbonyl, Cycloalkoxycarbonyl, Cycloalkylalkoxycarbonyl, Alkoxycarbonylalkyl, Arylalkoxycarbonyl, Arylalkoxycarbonyl, Arylalkoxycarbonylalkyl, Alkynyl, Alkynylalkyl, Alkylalkynyl, Tris-alkylsilylalkyny
  • Suitable substituents for a substituted heterocyclic radical are the substituents mentioned below, as well as oxo and thioxo.
  • the oxo group as a substituent on a ring C atom then means, for example, a carbonyl group in the heterocyclic ring. This preferably also includes lactones and lactams.
  • the oxo group can also occur on the hetero ring atoms, which can exist in different oxidation states, e.g. with N and S, and then form, for example, the divalent groups N(O), S(O) (also short SO) and S(O) 2 (also short SO 2 ) in the heterocyclic ring.
  • N(O), S(O) (also short SO) and S(O) 2 (also short SO 2 ) in the heterocyclic ring.
  • -N(O)- and -S(O)- groups both enantiomers are included.
  • heteroaryl stands for heteroaromatic compounds, i. H. completely unsaturated aromatic heterocyclic compounds, preferably 5- to 7-membered rings having 1 to 4, preferably 1 or 2, identical or different heteroatoms, preferably O, S or N.
  • heteroaryls are 1H-pyrrol-1-yl; 1H-pyrrol-2-yl; 1H-pyrrol-3-yl; furan-2-yl; furan-3-yl; thien-2-yl; thien-3-yl, 1H-imidazol-1-yl; 1H-imidazol-2-yl; 1H-imidazol-4-yl; 1H-imidazol-5-yl; 1H-pyrazol-1-yl; 1H-pyrazol-3-yl; 1H-pyrazol-4-yl; 1H-pyrazol-5-yl, 1H-1,2,3-triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-pyrrol-1-
  • heteroaryl groups according to the invention can also be substituted with one or more identical or different radicals. If two adjacent carbon atoms are part of another aromatic ring, these are fused heteroaromatic systems, such as benzo-fused or multiply fused heteroaromatics.
  • fused heteroaromatic systems such as benzo-fused or multiply fused heteroaromatics.
  • Preferred are, for example, quinolines (e.g. quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, quinolin-5-yl, quinolin-6-yl, quinolin-7-yl, quinolin-8-yl ); isoquinolines (e.g.
  • heteroaryl are also 5- or 6-membered benzo-fused rings from the group 1H-indol-1-yl, 1H-indol-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H- Indol-5-yl, 1H-indol-6-yl, 1H-indol-7-yl, 1-benzofuran-2-yl, 1-benzofuran-3-yl, 1-benzofuran-4-yl, 1-benzofuran- 5-yl, 1-benzofuran-6-yl, 1-benzofuran-7-yl, 1-benzothiophen-2-yl, 1-benzothiophen-3-yl, 1-benzothiophen-4-yl, 1-benzothiophen-5- yl, 1-benzothiophen-6-yl, 1-benzothiophen-7-yl, 1H-indazol-1-yl, 1H-indazol-3-yl, 1
  • halogen means, for example, fluorine, chlorine, bromine or iodine.
  • halo means, for example, fluoro, chloro, bromo or iodo.
  • alkyl means a straight-chain or branched, open-chain, saturated hydrocarbon radical which is optionally mono- or polysubstituted and, in the latter case, is referred to as “substituted alkyl”.
  • Preferred substituents are halogen atoms, alkoxy, haloalkoxy, cyano, alkylthio, haloalkylthio, amino or nitro groups, particularly preferred are methoxy, methyl, fluoroalkyl, cyano, nitro, fluorine, chlorine, bromine or iodine.
  • bis also includes the combination of different alkyl radicals, e.g. methyl(ethyl) or ethyl(methyl).
  • "Haloalkyl”, "-alkenyl” and “alkynyl” mean alkyl, alkenyl or alkynyl, e.g. B.
  • perhaloalkyl such as e.g. B. CCl3, CClF2, CFCl2, CF2CClF2, CF2CClFCF3; polyhaloalkyl such as e.g. e.g., CH2CHFCl, CF2CClFH, CF2CBrFH, CH2CF3;
  • perhaloalkyl also includes the term perfluoroalkyl.
  • Partially fluorinated alkyl means a straight-chain or branched, saturated hydrocarbon which is substituted one or more times by fluorine, where the corresponding fluorine atoms can be present as substituents on one or more different carbon atoms of the straight-chain or branched hydrocarbon chain, such as e.g.
  • Partially fluorinated haloalkyl means a straight-chain or branched, saturated hydrocarbon substituted by various halogen atoms having at least one fluorine atom, with all other optionally present halogen atoms being selected from the group fluorine, chlorine or bromine, iodine.
  • the corresponding halogen atoms can be present as substituents on one or more different carbon atoms of the straight-chain or branched hydrocarbon chain.
  • Partially fluorinated haloalkyl also includes complete substitution of the straight or branched chain with halogen involving at least one fluorine atom.
  • haloalkoxy is OCF 3 , OCHF 2 , OH 2 F, OCF 2 CF 3 , OH 2 CF 3 and OCH 2 CH 2 Cl; The same applies to haloalkenyl and other radicals substituted by halogen.
  • (C 1 -C 4 )-Alkyl means an abbreviation for straight-chain or branched alkyl with one to 4 carbon atoms corresponding to the range specified for carbon atoms, i.e.
  • alkyl radicals with a larger specified range of carbon atoms e.g. "(C 1 -C 6 )-Alkyl” accordingly also include straight-chain or branched alkyl radicals with a larger number of carbon atoms, i.e. according to the example also the alkyl radicals with 5 and 6 carbon atoms.
  • hydrocarbon radicals such as alkyl, alkenyl and alkynyl radicals, also in compound radicals, which preferably have lower carbon structures, for example with 1 to 6 carbon atoms or, in the case of unsaturated groups, with 2 to 6 carbon atoms e.g., methyl, ethyl, n- or i-propyl, n-, i-, t- or 2-butyl, pentyls, hexyls such as n-hexyl, i-hexyl and 1,3-dimethylbutyl, heptyls such as n-heptyl , 1-methylhexyl and 1,4-dimethylpentyl; alkenyl and alkynyl radicals have the meaning of the possible unsaturated radicals corresponding to the alkyl radicals, where at least one double bond or triple bond is present.
  • radicals having a double bond or triple bond Preference is given to radicals having a double bond or triple bond.
  • alkenyl concludes esp especial also straight-chain or branched open-chain hydrocarbon radicals with more than one double bond, such as 1,3-butadienyl and 1,4-pentadienyl, but also allenyl or cumulenyl radicals with one or more cumulative double bonds, such as allenyl (1,2 -propadienyl), 1,2-butadienyl and 1,2,3-pentatrienyl.
  • Alkenyl means, for example, vinyl, which can optionally be substituted by further alkyl radicals, for example (but not limited to) (C 2 -C 6 )-alkenyl such as ethenyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl- 2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1- butenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl
  • alkynyl also includes in particular straight-chain or branched open-chain hydrocarbon radicals with more than one triple bond or with one or more triple bonds and one or more double bonds, such as 1,3-butatrienyl or 3-pentene-1-in-1 -yl.
  • (C 2 -C 6 )-Alkynyl means, for example, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl , 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl , 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3 -p
  • cycloalkyl means a carbocyclic, saturated ring system preferably having 3-8 ring C atoms, e.g. cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, which is optionally further substituted, preferably by hydrogen, alkyl, alkoxy, cyano, nitro, alkylthio , haloalkylthio, halogen, alkenyl, alkynyl, haloalkyl, amino, alkylamino, bisalkylamino, alcocycarbonyl, hydroxycarbonyl, arylalkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl.
  • cyclic systems with substituents are included, with substituents having a double bond on the cycloalkyl radical, e.g. an alkylidene group such as methylidene.
  • polycyclic aliphatic systems are also included, such as bicyclo[1.1.0]butan-1-yl, bicyclo[1.1.0]butan-2-yl, bicyclo[2.1.0]pentan-1-yl , bicyclo[1.1.1]pentan-1-yl, bicyclo[2.1.0]pentan-2-yl, bicyclo[2.1.0]pentan-5-yl, bicyclo[2.1.1]hexyl, bicyclo[2.2.1 ]hept-2-yl, bicyclo[2.2.2]octan-2-yl, bicyclo[3.2.1]octan-2-yl, bicyclo[3.2.2]nonan-2-yl, adamantan-1-yl and adamantane -2-yl, but also systems such.
  • spirocyclic aliphatic systems are also included, such as spiro[2.2]pent-1-yl, spiro[2.3]hex-1-yl, spiro[2.3]hex-4-yl, 3-spiro[2.3] hex-5-yl, spiro[3.3]hept-1-yl, spiro[3.3]hept-2-yl.
  • Cycloalkenyl means a carbocyclic, non-aromatic, partially unsaturated ring system preferably having 4-8 carbon atoms, e.g.
  • C 1 -C 10 )-Alkylidene means the radical of a straight-chain or branched open-chain hydrocarbon radical which is bonded via a double bond.
  • Cycloalkylidene means a carbocyclic radical bonded via a double bond.
  • Cycloalkylalkyloxy means an oxygen-bonded cycloalkylalkyl radical and "arylalkyloxy” means an oxygen-bonded arylalkyl radical.
  • Alkoxyalkyl means an alkoxy radical bonded through an alkyl group and "alkoxyalkoxy” means an alkoxyalkyl radical bonded through an oxygen atom, such as (but not limited to) methoxymethoxy, methoxyethoxy, ethoxyethoxy, methoxy-n-propyloxy.
  • Alkylthioalkyl means an alkylthio radical bonded through an alkyl group and “alkylthioalkylthio” means an alkylthioalkyl radical bonded through an oxygen atom.
  • Arylalkoxyalkyl means an aryloxy radical bonded through an alkyl group and “heteroaryloxyalkyl” means a heteroaryloxy radical bonded through an alkyl group.
  • Haloalkoxyalkyl means a linked haloalkoxy radical and "haloalkylthioalkyl” means a haloalkylthio radical linked through an alkyl group.
  • Arylalkyl means an aryl radical bonded through an alkyl group
  • heteroarylalkyl means a heteroaryl radical bonded through an alkyl group
  • heterocyclylalkyl means a heterocyclyl radical bonded through an alkyl group.
  • Cycloalkylalkyl represents a cycloalkyl radical bonded via an alkyl group, e.g. B.
  • Arylalkenyl means an aryl radical bonded through an alkenyl group
  • heteroarylalkenyl means a heteroaryl radical bonded through an alkenyl group
  • heterocyclylalkenyl means a heterocyclyl radical bonded through an alkenyl group
  • Arylalkynyl means an aryl radical bonded through an alkynyl group
  • heteroarylalkynyl means a heteroaryl radical bonded through an alkynyl group
  • heterocyclylalkynyl means a heterocyclyl radical bonded through an alkynyl group
  • haloalkylthio on its own or as part of a chemical group—is straight-chain or branched S-haloalkyl, preferably having 1 to 8 or 1 to 6 carbon atoms, such as (C 1 -C 8th )-, (C 1 -C 6 )- or (C 1 -C 4 )-haloalkylthio such as (but not limited to) trifluoromethylthio, pentafluoroethylthio, difluoromethyl, 2,2-difluoroeth-1-ylthio, 2,2,2-difluoroeth-1-ylthio, 3,3,3-prop-1-ylthio .
  • Halocycloalkyl and halocycloalkenyl denote identical or different halogen atoms, such as e.g. B. F, Cl and Br, or by haloalkyl, such as. B. trifluoromethyl or difluoromethyl partially or fully substituted cycloalkyl or cycloalkenyl, e.g.
  • Trialkylsilyl - alone or as part of a chemical group - for straight-chain or branched Si-alkyl, preferably with 1 to 8, or with 1 to 6 carbon atoms, such as tri-[(C 1 -C 8th )-, (C 1 -C 6 )- or (C 1 -C 4 )-alkyl]silyl, such as (but not limited to) trimethylsilyl, triethylsilyl
  • Trialkylsilylalkynyl represents a trialkylsilyl radical bonded through an alkynyl group. If the compounds can form tautomers by hydrogen shift which would not be formally covered by formula (I) structurally, then these tautomers are nevertheless within the definition of the compounds of the formula (I) according to the invention, unless a specific tautomer is the subject of consideration. For example, many carbonyl compounds can exist in both the keto form and the enol form, both forms being encompassed by the definition of the compound of formula (I). Depending on the type and linkage of the substituents, the compounds of the general formula (I) can be present as stereoisomers.
  • stereoisomers defined by their specific spatial form such as enantiomers, diastereomers, Z and E isomers are all encompassed by the formula (I). If, for example, one or more alkenyl groups are present, diastereomers (Z and E isomers) can occur. For example, if one or more asymmetric carbon atoms are present, enantiomers and diastereomers can occur.
  • Stereoisomers can be obtained from the mixtures obtained in the preparation by customary separation methods. The chromatographic separation can be carried out both on an analytical scale to determine the enantiomeric excess or diastereomeric excess and on a preparative scale to produce test specimens for biological testing.
  • stereoisomers can be prepared selectively by using stereoselective reactions using optically active starting materials and/or auxiliaries.
  • the invention thus also relates to all stereoisomers which are covered by the general formula (I) but are not specified with their specific stereo form, and mixtures thereof. If the compounds are obtained as solids, they can also be purified by recrystallization or digestion. If individual compounds (I) are not satisfactorily accessible by the routes described below, they can be prepared by derivatizing other compounds (I). Suitable methods for isolating, purifying and separating stereoisomers of compounds of the formula (I) are methods which are generally known to the person skilled in the art from analogous cases, e.g.
  • any remaining mixtures can usually be separated by chromatographic separation, e.g. on chiral solid phases.
  • processes such as crystallization, e.g. Synthesis
  • the compounds of the general formula (I) according to the invention can be prepared via various synthesis routes described in the literature, starting from starting substances that are commercially available or easily prepared.
  • the substituted pyrrolidinones of the general formula (I.1) can be prepared using a synthesis described in the literature (J. Org.
  • the pyrrolidinone (I.1a) resulting from the ring-closure reaction can then be 5.2 ⁇ 5 ,4 ⁇ 5 ,6 ⁇ 5 -trioxatriphosphinan-2,4,6-trioxide (T3P), hydroxybenzotriazole (HOBt)] using a suitable base (e.g. triethylamine or diisopropylethylamine) in a suitable polar-aprotic solvent (e.g. dichloromethane) into the corresponding esters (I.1b) or amides (I.1c) are converted.
  • a suitable base e.g. triethylamine or diisopropylethylamine
  • a suitable polar-aprotic solvent e.g. dichloromethane
  • oxopyrrolidinyl esters (I.1d) using a two-stage Chain extension from the corresponding oxopyrrolidinyl carboxylates (C) are prepared.
  • the carboxylic acid ester (C) in question is first converted into the intermediate alcohol (D) using a suitable reducing agent (e.g. sodium or lithium borohydride), which is then converted to the desired target product (I.1d ) (Chemistry - A European Journal (2017), 23, 7428-7432I).
  • a suitable reducing agent e.g. sodium or lithium borohydride
  • the substituted pyrrolidinones of the general formulas (I.3), (I.4) and (I.5) can also be prepared via synthesis routes described in the literature (cf. WO2012098132).
  • a suitable, optionally further substituted itaconic acid (E) with a suitable, optionally further substituted amine, preferably an alkyl, cycloalkyl, aryl or heteroarylmethylamine, at elevated temperature (e.g. 150° C.), the corresponding 5-oxopyrrolidinyl-3 -carboxylic acid (F) obtained (scheme 3).
  • the ring-closure reaction can be carried out in a conventional synthesis apparatus with a heating bath or in a suitable sealed vessel under microwave conditions.
  • the intermediate carboxylic acid (E) resulting from the ring-closure reaction can then be synthesized using suitable coupling reagents [e.g. 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), 2,4,6-tripropyl-1,3,5,2 ⁇ 5 ,4 ⁇ 5 ,6 ⁇ 5 -trioxatriphosphinan-2,4,6-trioxide (T3P), hydroxybenzotriazole (HOBt)] using a suitable base (e.g. triethylamine or diisopropylethylamine) together with the corresponding optionally further substituted amine in a suitable polar-aprotic solvent (e.g.
  • suitable coupling reagents e.g. 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), 2,4,6-tripropyl-1,3,5,2 ⁇ 5 ,4 ⁇ 5 ,
  • the carboxylic acid (E) can be synthesized by suitable reagents [e.g. diphenylphosphoryl azide (DPPA), triethylamine and tert. Butanol]-mediated degradation reaction carried out at elevated temperature (e.g. 80 °C) can be converted into the corresponding protected amine (F).
  • suitable reagents e.g. diphenylphosphoryl azide (DPPA), triethylamine and tert. Butanol
  • DPPA diphenylphosphoryl azide
  • Butanol e.g. diphenylphosphoryl azide
  • Butanol tert. Butanol
  • Removal of the relevant protecting group here by way of example but not limitation a tert-butyloxycarbonyl (Boc) protecting group] using a suitable reagent (e.g.
  • amine (G) (optionally also as a salt, e.g. by way of example but not limitation as the HCl salt).
  • the amine (G) can with the help of suitable coupling partners (example, but not limiting with an optionally further substituted acetic acid chloride, an optionally further substituted isocyanate or an optionally further substituted isothiocyanate) using a suitable base (e.g. triethylamine or diisopropylethylamine) in a suitable polar-aprotic solvent (e.g.
  • the optionally further substituted intermediate (G) can also be prepared starting from a further substituted glycine ester (H) in a multi-stage reaction via acylation, subsequent cyclization using a suitable base (e.g. sodium hydride) in a suitable polar aprotic solvent (e.g. tetrahydrofuran), oxime formation using hydroxylamine hydrochloride and a suitable base in a suitable polar aprotic solvent (e.g. dichloromethane) and final reduction of the oxime using a suitable reducing agent (e.g. sodium cyanoborohydride and hydrogen over palladium on carbon) (Scheme 4) .
  • a suitable base e.g. sodium hydride
  • a suitable polar aprotic solvent e.g. tetrahydrofuran
  • oxime formation using hydroxylamine hydrochloride and a suitable base in a suitable polar aprotic solvent e.g. dichloromethane
  • the optionally further substituted ureas of the general formula (I.4) can be prepared starting from a substituted amino acid (J) provided with suitable protective groups (cf. WO2006063113).
  • the base-mediated reaction of the amino acid (J) with a suitable isocyanate to form an optionally further substituted intermediate (K) takes place first.
  • the intermediate, optionally further substituted carboxylic acid (K) obtained in this way can then be 2 ⁇ 5 ,4 ⁇ 5 ,6 ⁇ 5 -trioxatriphosphinan-2,4,6-trioxide (T3P), hydroxybenzotriazole (HOBt)] using a suitable base (e.g. triethylamine or diisopropylethylamine) together with the appropriate amine R 1 -NH2 in a suitable polar-aprotic solvent (e.g.
  • the compounds of type I.2 could also be prepared analogously to the instructions from patent application WO2011/35332 (Scheme 6).
  • the corresponding pyrrolidonecarboxylic acids (O) are prepared by condensation of the corresponding anilines with itaconic acid derivatives (M). After esterification of the acids (O), e.g. using orthoesters or other methods, the corresponding carboxylic acid esters (P) are obtained. After deprotonation with a strong base such as e.g with an alkylating agent such as an alkyl halide such as methyl iodide or dimethyl sulfate to give the alkylated pyrrolidone carboxylic acid esters (Q).
  • a strong base such as e.g with an alkylating agent such as an alkyl halide such as methyl iodide or dimethyl sulfate
  • reaction mixture was stirred at room temperature for 1 hour. This was followed by the dropwise addition of triethylamine (376.0 mg, 0.52 mL, 3.71 mmol, 5.0 eq.) and the addition of DMAP (18.0 mg, 0.14 mmol.0.2 eq.), and the resulting reaction mixture was stirred at room temperature for 16 h. Then water (20 mL) was added and the aqueous phase was thoroughly extracted with dichloromethane (3 x 50 mL). The combined organic phases were dried over magnesium sulfate, filtered and concentrated under reduced pressure.
  • Trans-3-hexenedioic acid 300 mg, 2.08 mmol
  • 1-(2,3,6-trifluorophenyl)methylamine 335 mg, 2.08 mmol
  • the pressure rose to 18 bar. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure.
  • reaction mixture was stirred at room temperature for 1 h and then triethylamine (0.37 mL, 2.62 mmol, 3.0 eq.) was added dropwise.
  • the resulting reaction mixture was stirred at room temperature for a further 8 h and then treated with water (20 mL) and thoroughly extracted several times with dichloromethane (3 x 50 mL). The combined organic phases were dried over magnesium sulfate, filtered off and concentrated under reduced pressure.
  • I.2-33 1-[3,5-Bis(trifluoromethyl)phenyl]-N- ⁇ [2-(ethylamino)pyrimidin-4-yl]methyl ⁇ -5-oxopyrrolidine-3-carboxamide
  • the pH of the remaining aqueous phase was adjusted to 3-4 with 2N hydrochloric acid and the aqueous phase was extracted twice with 500 mL ethyl acetate each time. After drying the combined ethyl acetate phases over sodium sulfate, it was filtered and the Solvent removed in vacuo. The residue was suspended in 50 mL hexane (5 h), filtered off and washed with hexane. 5.40 g (purity 98%, 76% of theory) of the desired 1-(3,5-dichlorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxylic acid were obtained as a colorless solid.
  • 1-(2-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid was obtained in the form of a colorless solid by recrystallization from ethyl acetate and used in the next reaction step without further purification.
  • 1-(2-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (48.8 mmol, 1 equiv.) was dissolved in tert. Butanol (100 mL) and treated with diphenylphosphoryl azide (58.8 mmol, 1.2 equiv) and triethylamine (146.4 mmol, 3.0 equiv). The resulting reaction mixture was stirred at 80° C.
  • Butanol (100 mL) and treated with diphenylphosphoryl azide (58.8 mmol, 1.2 equiv) and triethylamine (146.4 mmol, 3.0 equiv).
  • the resulting reaction mixture was stirred at 80° C. for 2 h, concentrated under reduced pressure after cooling to room temperature and the crude product obtained was taken up without further purification in a mixture of hydrochloric acid and ethyl acetate (100 mL) and stirred at room temperature for 16 h. The precipitated solid was filtered off and dried.
  • 4-amino-1-cyclopropylpyrrolidin-2-one as a hydrochloride salt in the form of a Colorless solid be obtained.4-amino-1-cyclopropyl-pyrrolidin-2-one hydrochloride salt (150 mg, 0.85 mmol) was abs in a heated round bottom flask. Dissolved dichloromethane (5 mL) and treated with triethylamine (0.30 mL, 2.12 mmol). After stirring at room temperature for 10 minutes, 2,5-dichlorophenylacetic acid chloride (209 mg, 0.93 mmol) was added. The resulting reaction mixture was stirred at room temperature for 2 h, treated with water and dichloromethane and thoroughly extracted.
  • N-Phenylglycine ethyl ester (60 mmol, 1 equiv) and diisopropylethylamine (120 mmol, 2 equiv) were placed together in a heated round bottom flask, dissolved in abs. Dissolved dichloromethane (150 mL) and treated with propionyl chloride (120 mmol, 2 equiv.). The resulting reaction mixture was stirred at room temperature for 16 h and then concentrated under reduced pressure. After addition of saturated sodium bicarbonate solution and ethyl acetate, the aqueous phase was extracted three times with ethyl acetate (200 mL in total).
  • N-propionyl-N-phenylglcin ethyl ester was obtained and used in the next reaction step without further purification.
  • N-Propionyl-N-phenylglcin ethyl ester (60 mmol, 1.0 equiv.) was dissolved in abs. Dissolved tetrahydrofuran and carefully treated with sodium hydride (180 mmol, 3 equiv.). The resulting reaction mixture was stirred at a temperature of 65°C for 48 hours. After cooling to room temperature, the reaction mixture was quenched by adding ethanol dropwise and then concentrated under reduced pressure.
  • 1-phenyl-3,5-dioxo-4-methylpyrrolidine was obtained in the form of a colorless solid.1-Phenyl-3,5-dioxo-4-methylpyrrolidine (30.0 mmol , 1 equiv.) was dissolved in dichloromethane (100 mL) and treated with hydroxylamine hydrochloride (36.0 mmol, 1.2 equiv.) and diisopropylethylamine (60 mmol, 2.0 equiv.).
  • the resulting reaction mixture was stirred at room temperature for 16 h, concentrated under reduced pressure and the crude product obtained without further purification taken up in methanol (100 mL), treated with palladium on carbon (1.0 g) and stirred at room temperature under a hydrogen atmosphere (1 bar) for 16 h. Thereafter, the reaction mixture was filtered through Celite and concentrated under reduced pressure. The residue was taken up in acetic acid (50 mL) and treated with sodium cyanoborohydride (60 mmol, 2 equiv). The reaction mixture was stirred at room temperature for a further 16 h and again concentrated.
  • I.4-36 1-(5-Chloro-2-methylphenyl)-3-[1-phenyl-5-oxopyrrolidin-3-yl]urea. Itaconic acid (100 mmol, 1 equiv) and aniline (100 mmol, 1 equiv) were placed together in a heated round bottom flask and stirred at a temperature of 150 °C for 16 h. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure.
  • Table I.1 Preferred for the use of compounds of formula (I.1) are the compounds I.1-1 to I.1-605, wherein R 1 , R 4 , R 13 and X have the meanings of Table I.1 given in the respective row and R 3 , R 5 , R 6 , R 7 and R 14 are hydrogen and where X is a moiety O-R 36 or N(R 15 )r 35 stands.
  • the stereochemistry at carbon C-2 is defined by "RAC” for a mixture of both stereo configurations at carbon C-2, "Ent-1” and “Ent-2” for one enantiomer (or diastereomer if there are several stereocenters in the molecule) with one Stereo configuration given at carbon C-2.
  • Table I.1 The stereochemistry at carbon C-2 is defined by "RAC” for a mixture of both stereo configurations at carbon C-2, "Ent-1” and “Ent-2” for one enantiomer (or diastereomer if there are several stereocenters in the molecule) with one Stereo configuration given at carbon C-2.
  • Table I.2 Preferred for the use of compounds of formula (I.2) are the compounds I.2-1 to I.2-182, wherein R 1 , R 3 , R 4 , R 5 , R 20 , R 21 and R 37 have the meanings given in Table I.2 in the respective row and R 2 , R 6 and R 22 are hydrogen.
  • the bonds marked with an asterisk (*) of the groups formed jointly by R3 and R5 indicate the bonds to the pyrrolidinone ring.
  • R 21 and R 37 together with the carbon atom to which they are attached form a ring system which can optionally also be bicyclic. The ring system formed in this way, including the carbon atom, is then indicated accordingly in a common column for R 21 and R 37 .
  • Table I.2 Preferred for the use of compounds of formula (I.2) are the compounds I.2-1 to I.2-182, wherein R 1 , R 3 , R 4 , R 5 , R 20 , R 21 and R 37 have the meanings given in Table I.
  • Table I.3 Preferred for the use of compounds of the formula (I.3) are the compounds I.3-1 to I.3-37, in which R 1 , R 3 , R 5 , R 10 and R 37 are in have the meanings of Table I.3 given in the respective row and R 2 , R 4 , R 6 , R 11 and R 12 are hydrogen. Table I.3
  • Table I.4 Preferred for the use of compounds of the formula (I.4) are the compounds I.4-1 to I.4-141, in which R 1 , R 3 , R 5 and R 37 are those in the respective line have the meanings given in Table I.4 and R 2 , R 4 , R 6 , R 8 and R 9 are hydrogen. Table I.4
  • Table I.5 Preferred for the use of compounds of the formula (I.5) are the compounds I.5-1 to I.5-34, in which R 1 , R 3 , R 5 and R 37 are those in the respective line have the meanings given in Table I.5 and R 2 , R 4 and R 6 are hydrogen. , Table I.5 4
  • Spectroscopic data of selected examples in the table were obtained either via classical NMR interpretation and/or via 1 H NMR peak list method evaluated.
  • I.4-32 1 H NMR (400 MHz, i.e 6 -DMSO) ⁇ ppm 8.89 (s, 1H), 8.43 (d, 1H), 7.97-7.93 (m, 1H), 7.59 (d, 1H), 7.46-7.38 (m, 4H), 7.01 (m, 1H) , 4.52-4.45 (m, 1H), 4.02-3.97 (m, 1H), 3.59-3.54 (dd, 1H), 2.89-2.82 (dd, 1H), 2.45-2.38 (dd, 1H).
  • Example No. I.4-34 1 H NMR (400 MHz, d6-DMSO) ⁇ ppm 9.26 (s, 1H), 8.93 (br.
  • the peak list of an example therefore has the form: ⁇ 1 (intensity1 ) ; ⁇ 2 (intensity2);........; ⁇ i (intensityi ) ; whil; ⁇ n (intensitiesn)
  • the intensity of sharp signals correlates with the height of the signals in a printed example of an NMR spectrum in cm and shows the true ratios of the signal intensities. For broad signals, multiple peaks or the center of the signal and their relative intensity compared to the most intense signal in the spectrum can be shown.
  • To calibrate the chemical shift of 1 H-NMR spectra use tetramethylsilane and/or solvent chemical shift, especially in the case of spectra measured in DMSO.
  • the tetramethylsilane peak can therefore appear in NMR peak lists, but it does not have to.
  • the lists of 1 H NMR peaks are similar to classic 1H NMR plots and thus usually include all peaks listed in a classic NMR interpretation.
  • they can show signals from solvents, signals from stereoisomers of the target compounds, which are also the subject of the invention, and/or peaks from impurities.
  • our lists of 1H NMR peaks are the usual solvent peaks, for example peaks from DMSO in DMSO-D 6 and the peak of water, which usually have high intensity on average.
  • the peaks of stereoisomers of the target compounds and/or peaks of impurities usually have on average a lower intensity than the peaks of the target compounds (e.g. with a purity of >90%). Such stereoisomers and/or impurities can be typical of the particular production process. Their peaks can thus help identify the reproduction of our manufacturing process using “by-product fingerprints”.
  • An expert who calculates the peaks of the target compounds with known methods can isolate the peaks of the target compounds as required, with additional intensity filters being used if necessary. This isolation would be similar to the peak picking involved in classical 1H NMR interpretation. More details about 1 H NMR peak lists can be found in Research Disclosure Database Number 564025.
  • Another subject of the present invention is a spray solution for treating plants, containing an amount of at least one compound selected from the group consisting of at least one of the substituted pyrrolidinones according to the invention, of the general formula (I ).
  • the abiotic stress conditions that can be put into perspective include, for example, heat, drought, cold and drought stress (stress caused by drought and/or lack of water), osmotic stress, waterlogging, increased soil salinity, increased exposure to minerals, ozone conditions, strong light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients.
  • the corresponding pyrrolidinones of the general formula (I) substituted according to the invention can be applied by spray application to plants or parts of plants to be treated accordingly.
  • the compounds of the general formula (I) or their salts are preferably used at a dosage of between 0.00005 and 3 kg/ha, particularly preferably between 0.0001 and 2 kg/ha, particularly preferably between 0.0005 and 1 kg/ha. ha, especially preferably between 0.001 and 0.25 kg/ha.
  • the term resistance or resilience to abiotic stress is understood to mean various advantages for plants.
  • Such advantageous properties are expressed, for example, in the improved plant characteristics mentioned below: improved root growth in terms of surface and depth, increased stolon formation or tillering, stronger and more productive stolons and tillers, improvement in shoot growth, increased stability, increased shoot base diameter, increased leaf area, higher yields of nutrients and ingredients such as carbohydrates, fats, oils, proteins, vitamins, minerals, essential oils, dyes, fibres, better fiber quality, earlier flowering, increased number of flowers, reduced levels of toxic products such as mycotoxins, reduced levels of residues or unfavorable components of any kind or better digestibility, improved storage stability of the crop, improved tolerance to unfavorable temperatures, improved tolerance to drought and drought, as well as water starvation excess, improved tolerance to increased salt levels in soil and water, increased tolerance to ozone stress, improved tolerance to herbicides and other plant treatment products, improved water absorption and photosynthetic performance, advantageous plant properties, such as accelerated ripening, more even ripening, greater attraction for beneficial organisms, improved pollination or other advantages well known
  • Such terms are, for example, the terms listed below: phytotonic effect, resistance to stress factors, less plant stress, plant health, healthy plants, plant fitness (“Plant Fitness”), “Plant Wellness”, “Plant Concept”, “Vigor Effect”, “Stress Shield, Crop Health, Crop Health Properties, Crop Health Products, Crop Health Management, Crop Health Therapy, Plant Health, Plant Health Properties, Plant Health Products, Plant Health Management", “Plant Health Therapy”, “Greening Effect” or “Re-greening Effect”), "Freshness” or other terms well known to a person skilled in the art.
  • a good effect on abiotic stress resistance is not limited • at least one emergence improved by generally 3%, in particular greater than 5%, particularly preferably greater than 10%, • at least one yield increased by generally 3%, in particular greater than 5%, particularly preferably greater than 10%, • at least one by im Generally 3%, in particular greater than 5%, particularly preferably greater than 10% improved root development, • at least one shoot size increasing by generally 3%, in particular greater than 5%, particularly preferably greater than 10%, • at least one by generally 3%, in particular greater than 5%, particularly preferably greater than 10%, • at least one photosynthesis performance improved by generally 3%, in particular greater than 5%, particularly preferably greater than 10% and/or • at least one by generally 3%, in particular greater understood as 5% particularly preferably greater than 10% improved flower formation, the effects being individual or in any combination ion of two or more effects can occur.
  • the present invention further provides a spray solution for treating plants, containing an amount of at least one compound from the group of substituted pyrrolidinones of the general formula (I) effective to increase the resistance of plants to abiotic stress factors.
  • the spray solution can contain other customary components, such as solvents, formulation auxiliaries, in particular water. Other components can be, inter alia, agrochemical active ingredients, which are described in more detail below.
  • Another object of the present invention is the use of corresponding spray solutions to increase the resistance of plants to abiotic stress factors. The statements below apply both to the use of one or more compounds of the general formula (I) according to the invention per se and to the corresponding spray solutions.
  • Fertilizers which can be used according to the invention together with the compounds of the general formula (I) according to the invention explained in more detail above are generally organic and inorganic nitrogen-containing compounds such as ureas, urea-formaldehyde condensation products, amino acids, ammonium salts and nitrates, potassium salts (preferably chlorides, sulfates, nitrates), phosphoric acid salts and/or salts of phosphorous acid (preferably potassium salts and ammonium salts).
  • NPK fertilizers i.e.
  • fertilizers that contain nitrogen, phosphorus and potassium, calcium ammonium nitrate, i.e. fertilizers that also contain calcium, ammonium sulphate nitrate (general formula (NH4)2SO4 NH4NO3), ammonium phosphate and ammonium sulphate.
  • NH42SO4 NH4NO3 calcium, ammonium sulphate nitrate
  • ammonium phosphate and ammonium sulphate generally known to those skilled in the art, see also, for example, Ullmann's Encyclopedia of Industrial Chemistry, 5th Edition, Vol. A 10, pages 323 to 431, Verlagsgesellschaft, Weinheim, 1987.
  • the fertilizers can also contain salts from micronutrients (preferably calcium, boron, manganese, magnesium, iron, boron, copper, zinc, molybdenum and cobalt) and phytohormones (e.g.
  • Fertilizers used according to the invention can also contain other salts such as monoammonium phosphate (MAP), diammonium phosphate (DAP), potassium sulfate, potassium chloride, magnesium sulfate.
  • MAP monoammonium phosphate
  • DAP diammonium phosphate
  • Suitable amounts for the secondary nutrients or trace elements are amounts of 0.5 to 5% by weight, based on the fertilizer as a whole.
  • Other possible ingredients are crop protection agents, insecticides, fungicides, safeners or growth regulators or mixtures thereof. Further explanations on this follow below.
  • the fertilizers can be used, for example, in the form of powders, granules, prills or compacts.
  • the fertilizers can also be used in liquid form, dissolved in an aqueous medium.
  • diluted aqueous ammonia can also be used as a nitrogen fertilizer.
  • Further possible ingredients for fertilizers are described, for example, in Ullmann's Encyclopedia of Industrial Chemistry, 5th edition, 1987, volume A 10, pages 363 to 401, DE-A 4128828, DE-A 1905834 and DE-A 19631764.
  • the general composition of the fertilisers which in the context of the present invention can be straight and/or complex fertilizers, for example nitrogen, potassium or phosphorus, can vary within a wide range.
  • a content of 1 to 30% by weight nitrogen (preferably 5 to 20% by weight), 1 to 20% by weight potassium (preferably 3 to 15% by weight) and a content of 1 to 20% by weight phosphorus (preferably 3 to 10% by weight) is advantageous.
  • the content of microelements is usually in the ppm range, preferably in the range from 1 to 1000 ppm.
  • the fertilizer and one or more compounds of the general formula (I) according to the invention can be administered simultaneously. However, it is also possible first to use the fertilizer and then to use one or more compounds of the general formula (I) according to the invention, or first to use one or more compounds of the general formula (I) and then to use the fertilizer.
  • one or more compounds of the general formula (I) and the fertilizer are not used at the same time, the application in the context of the present invention takes place in a functional context, in particular within a period of generally 24 hours, preferably 18 hours, particularly preferably 12 hours, specifically 6 hours, even more special 4 hours, even more special within 2 hours.
  • one or more compounds of the formula (I) according to the invention and the fertilizer are applied within a time frame of less than 1 hour, preferably less than 30 minutes, particularly preferably less than 15 minutes.
  • Forest stock includes trees for the manufacture of wood, pulp, paper and products made from parts of the trees.
  • useful plants as used here, refers to crop plants that are used as plants for the production of food, animal feed, fuel or for technical purposes.
  • the useful plants include B.
  • triticale durum (hard wheat), turf, vines, cereals, for example wheat, barley, rye, oats, rice, maize and millet
  • Beet for example sugar beet and fodder beet
  • Fruits for example pome fruit, stone fruit and berries, for example apples, pears, plums, peaches, almonds, cherries and berries, e.g. B.
  • strawberries, raspberries, blackberries legumes such as beans, lentils, peas and soybeans
  • Oil crops for example rapeseed, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans and peanuts
  • cucumber plants such as squash, cucumbers and melons
  • fiber crops such as cotton, flax, hemp and jute
  • citrus fruits e.g.
  • vegetables for example spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes and peppers
  • Laurel plants for example avocado, cinnamomum, camphor, or plants such as tobacco, nuts, coffee, eggplant, sugar cane, tea, pepper, grapevines, hops, bananas, natural rubber plants and ornamental plants, for example flowers, shrubs, deciduous trees and conifers such as conifers. This list does not represent a limitation.
  • the following plants are to be regarded as particularly suitable target crops for the application of the method according to the invention: oats, rye, triticale, durum, cotton, eggplant, turf, pome fruit, stone fruit, soft fruit, corn, wheat, barley, cucumber, tobacco, vines, rice, cereals , pear, pepper, beans, soybeans, canola, tomato, pepper, melon, cabbage, potato and apple.
  • trees that can be improved according to the method of the present invention can be named: From the tree species Aesculus: A. hippocastanum, A. pariflora, A. carnea; from the tree species Platanus: P. aceriflora, P. occidentalis, P. racemosa; from the tree species Picea: P. abies; from the tree species Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. elliottii, P. montecola, P. albicaulis, P. resinosa, P. palustris, P. taeda, P. flexilis, P .jeffregi, P.
  • baksiana P. strobes; from the tree species Eucalyptus: E. grandis, E. globulus, E. camadentis, E. nitens, E. obliqua, E. regnans, E. pilularus.
  • Particularly preferred trees which can be improved according to the method according to the invention can be mentioned: From the tree species Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. strobes; from the tree species Eucalyptus: E. grandis, E. globulus and E. camadentis.
  • horse chestnut As particularly preferred trees which can be improved according to the method of the present invention, there can be mentioned: horse chestnut, sycamore, linden and maple tree.
  • the present invention can also be practiced on any turfgrasses, including cool season turfgrasses and warm season turfgrasses.
  • Examples of lawn types for the cold season are blue grasses (Poa spp.), such as Kentucky bluegrass (Poa pratensis L.), rough bluegrass (Poa trivialis L.), Canada bluegrass (Poa compressa L.), annual bluegrass (Poa annua L.), upland bluegrass (Poa glaucantha Gaudin), wood bluegrass (Poa nemoralis L.) and bulbous bluegrass (Poa bulbosa L.); Bentgrass (Agrostis spp.), such as creeping bentgrass (Agrostis palustris Huds.), colonial bentgrass (Agrostis tenuis Sibth.), velvet bentgrass (Agrostis canina L.), South German Mixed Bentgrass ' (Agrostis spp.
  • Agrostis tenius Sibth. including Agrostis tenius Sibth., Agrostis canina L., and Agrostis palustris Huds.), and 'redtop' (Agrostis alba L.); Fescues ("Fescues", Festucu spp.), such as “red fescue” (Festuca rubra L. spp.
  • Examples of other “cool season turfgrasses” are “beachgrass” (Ammophila breviligulata Fern.), “smooth bromegrass” (Bromus inermis Leyss.), “cattails” like “Timothy” (Phleum pratense L.), “sand cattail (Phleum subulatum L.), orchardgrass (Dactylis glomerata L.), weeping alkaligrass (Puccinellia distans (L.) Parl.) and crested dog's-tail (Cynosurus cristatus L.).
  • Examples of warm season turfgrasses are Bermudagrass (Cynodon spp. L.C.
  • crop plants can be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including transgenic plants and including plant varieties which can or cannot be protected by plant variety rights.
  • the treatment method according to the invention can thus also be used for the treatment of genetically modified organisms (GMOs), e.g. As plants or seeds can be used.
  • GMOs genetically modified organisms
  • Genetically modified plants (or transgenic plants) are plants in which a heterologous gene is stable in the genome has been integrated.
  • heterologous gene essentially means a gene that is provided or assembled outside of the plant and, when introduced into the nuclear genome, chloroplast genome, or hypochondriacal genome, confers new or improved agronomic or other traits on the transformed plant by producing a trait of interest protein or polypeptide, or that it downregulates or shuts down another gene(s) present in the plant (e.g., using antisense technology, co-suppression technology, or RNA interference [RNAi] technology) .
  • a heterologous gene that is present in the genome is also called a transgene.
  • a transgene that is defined by its specific presence in the plant genome is referred to as a transformation or transgenic event.
  • Plants and plant varieties that are preferably treated with the compounds of the general formula (I) according to the invention include all plants that have genetic material that gives these plants particularly advantageous, useful traits (regardless of whether this is achieved by breeding and/or biotechnology would).
  • Plants and plant cultivars which can also be treated with the compounds of the general formula (I) according to the invention are those plants which are resistant to one or more abiotic stress factors.
  • Abiotic stress conditions can include, for example, heat, drought, cold and drought stress, osmotic stress, waterlogging, increased soil salinity, increased exposure to minerals, ozone conditions, high light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients, or avoidance of shade.
  • Plants and plant cultivars which can also be treated with the compounds of the general formula (I) according to the invention are those plants which are characterized by increased yield-related properties.
  • An increased yield can be achieved with these plants e.g. B. based on improved plant physiology, improved plant growth and improved plant development, such as water use efficiency, water holding efficiency, improved nitrogen utilization, increased carbon assimilation, improved photosynthesis, enhanced germination and accelerated ripening.
  • Yield can be further influenced by improved plant architecture (under stressed and non-stressed conditions) including early flowering, control of flowering for hybrid seed production, seedling vigour, plant size, internodal number and spacing, root growth, seed size, fruit size, Pod size, number of pods or spikes, number of seeds per pod or spike, seed mass, increased seed filling, reduced seed loss, reduced pod bursting and stability.
  • plant architecture under stressed and non-stressed conditions
  • Other yield traits include seed composition such as carbohydrate content, protein content, oil content and oil composition, Nutritional value, reduction of anti-nutritional compounds, improved processability and improved shelf life.
  • Plants which can also be treated with the compounds of the general formula (I) according to the invention are hybrid plants which already express the properties of heterosis or the hybrid effect, which generally leads to higher yield, higher vigor, better health and better resistance to biotic and abiotic stressors.
  • Such plants are typically produced by crossing an inbred male-sterile parent line (the female parent) with another inbred male-fertile parent line (the male parent).
  • the hybrid seed is typically harvested from the male-sterile plants and sold to propagators.
  • Male-sterile plants can sometimes (e.g., in maize) be produced by detasseling (i.e., mechanically removing the male reproductive organs or male flowers); however, it is more common that male sterility is due to genetic determinants in the plant genome.
  • cytoplasmic male sterility have been described for example for Brassica species (WO92/005251, WO95/009910, WO98/27806, WO2005/002324, WO2006/021972 and US6,229,072).
  • male-sterile plants can also be obtained using plant biotechnology methods such as genetic engineering.
  • a particularly useful means of producing male-sterile plants is described in WO 89/10396, where for example a ribonuclease such as a barnase is selectively expressed in the tapetum cells in the stamens. Fertility can then be restored by expression of a ribonuclease inhibitor such as Barstar in the tapetum cells (e.g. WO91/002069).
  • Plants or plant cultivars which can also be treated with the compounds of general formula (I) according to the invention are herbicide-tolerant plants, i. H. Plants that have been made tolerant to one or more specified herbicides. Such plants can be obtained either by genetic transformation or by selection from plants containing a mutation conferring such herbicide tolerance.
  • Herbicide-tolerant plants are, for example, glyphosate-tolerant plants, i. H. Plants that have been made tolerant to the herbicide glyphosate or its salts.
  • glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS).
  • EPSPS 5-enolpyruvylshikimate-3-phosphate synthase
  • Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., Science (1983), 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp. (Barry et al., Curr. Topics Plant Physiol.
  • Glyphosate tolerant plants can also be obtained by expressing a gene encoding a glyphosate oxidoreductase enzyme as described in US5,776,760 and US5,463,175. Glyphosate tolerant plants can also be obtained by expressing a gene encoding a glyphosate acetyltransferase enzyme as described in e.g. B. WO2002/036782, WO2003/092360, WO2005/012515 and WO2007/024782. Glyphosate tolerant plants can also be obtained by selecting plants containing naturally occurring mutations of the genes mentioned above, as described for example in WO01/024615 or WO2003/013226.
  • herbicide-resistant plants are, for example, plants which have been made tolerant to herbicides which inhibit the enzyme glutamine synthase, such as bialaphos, phosphinotricin or glufosinate. Such plants can be obtained by expressing an enzyme that detoxifies the herbicide or a mutant of the enzyme glutamine synthase that is resistant to inhibition.
  • a potent detoxifying enzyme is, for example, an enzyme encoding a phosphinotricin acetyltransferase (such as the bar or pat protein from Streptomyces species).
  • Plants expressing an exogenous phosphinotricin acetyltransferase are described, for example, in US5,561,236; US5,648,477; US5,646,024; US5,273,894; US5,637,489; US5,276,268; US5,739,082; US5,908,810 and US7,112,665.
  • Other herbicide-tolerant plants are also plants that have been made tolerant to the herbicides that inhibit the enzyme hydroxyphenylpyruvate dioxygenase (HPPD).
  • HPPD hydroxyphenylpyruvate dioxygenases
  • the hydroxyphenylpyruvate dioxygenases are enzymes that catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is converted into homogentisate.
  • Plants that are tolerant to HPPD inhibitors can be endowed with a gene encoding a naturally occurring resistant HPPD enzyme or a gene encoding a mutant HPPD enzyme according to WO96/038567, WO99/024585 and WO99/024586 , to be transformed.
  • Tolerance to HPPD inhibitors can also be achieved by transforming plants with genes encoding encode certain enzymes that allow the formation of homogentisate despite inhibition of the native HPPD enzyme by the HPPD inhibitor. Such plants and genes are described in WO99/034008 and WO2002/36787.
  • the tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding a prephenate dehydrogenase enzyme in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO2004/024928 is described.
  • Other herbicide resistant plants are plants that have been made tolerant to acetolactate synthase (ALS) inhibitors.
  • ALS inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidines, pyrimidinyloxy(thio)benzoates and/or sulfonylaminocarbonyltriazolinone herbicides.
  • ALS also known as acetohydroxy acid synthase, AHAS
  • AHAS acetohydroxy acid synthase
  • WO2004/040012 WO2004/106529, WO2005/020673, WO2005/093093, WO2006/007373, WO2006/015376, WO2006/024351 and WO2006/060634 are described.
  • Other sulfonylurea- and imidazolinone-tolerant plants are also described, for example, in WO2007/024782.
  • plants that are tolerant to ALS inhibitors in particular to imidazolinones, sulfonylureas and/or sulfamoylcarbonyltriazolinones, can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or by mutation breeding, as is the case, for example, for the soybean in US5,084,082 , for rice in WO97/41218, for sugar beet in US5,773,702 and WO99/057965, for lettuce in US5,198,599 or for sunflower in WO2001/065922.
  • Plants or plant varieties obtained by methods of plant biotechnology, such as genetic engineering which can also be treated with the compounds of general formula (I) according to the invention are insect-resistant transgenic plants, i.e. plants which are resistant to infestation by certain target insects were made. Such plants can be obtained by genetic transformation or by selection from plants containing a mutation conferring such insect resistance.
  • insect resistant transgenic plant includes any plant containing at least one transgene comprising a coding sequence encoding: 1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal part thereof, such as the insecticidal crystal proteins that by Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, by Crickmore et al. (2005) in the Bacillus thuringiensis toxin nomenclature (online at: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal parts thereof, e.g.
  • the protein Cry1A.105 produced by the maize event MON98034 (WO2007/027777); or 4) a protein according to any one of points 1) to 3) above, in which some, in particular 1 to 10, amino acids have been replaced by another amino acid in order to achieve higher insecticidal activity against a target insect species and / or to the spectrum of to expand corresponding target insect species and/or due to changes induced in the coding DNA during cloning or transformation, such as the protein Cry3Bb1 in maize events MON863 or MON88017 or the protein Cry3A in maize event MIR 604; or 5) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus or an insecticidal part thereof, such as the vegetative insecticidal proteins (VIP) listed at the following link, e.g.
  • VIP vegetative insecticidal proteins
  • an insecticidal hybrid protein comprising parts of different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins of 1) or a hybrid of the proteins of 2) above; or 8) a protein according to any one of points 1) to 3) above, in which some, in particular 1 to 10, amino acids have been replaced by another amino acid in order to achieve higher insecticidal activity against a target insect species and / or to the spectrum of corresponding target insect species and/or because of changes induced in the coding DNA during cloning or transformation (while preserving the coding for an insecticidal protein), such as the protein VIP3Aa in the cotton event COT 102.
  • one of the insect-resistant transgenic plants in the present context also includes any plant comprising a combination of genes encoding the proteins of any of classes 1 to 8 above.
  • an insect-resistant plant contains more than one transgene encoding a protein according to any one of the above 1 to 8 in order to broaden the spectrum of the corresponding target insect species or to delay the development of resistance of the insects to the plants by employs different proteins that are insecticidal to the same target insect species but have a different mode of action, such as binding to different receptor-binding sites in the insect.
  • Plants or plant cultivars obtained by methods of plant biotechnology, such as genetic engineering which can also be treated with the compounds of general formula (I) according to the invention are tolerant to abiotic stress factors.
  • Such plants can be obtained by genetic transformation or by selection from plants containing a mutation conferring such stress resistance.
  • Particularly useful stress tolerant plants include the following: a. Plants containing a transgene capable of reducing the expression and/or activity of the gene for poly(ADP-ribose) polymerase (PARP) in the plant cells or plants, as described in WO2000/004173 or EP04077984.5 or EP06009836. 5 is described.
  • b Plants which contain a stress tolerance-promoting transgene which is able to reduce the expression and/or activity of the PARG-encoding genes of the plants or plant cells, as described, for example, in WO2004/090140; c.
  • Plants containing a stress tolerance promoting transgene encoding a plant functional enzyme of the nicotinamide adenine dinucleotide salvage biosynthetic pathway including Nicotinamidase, nicotinate phosphoribosyl transferase, nicotinic acid mononucleotide adenyl transferase, nicotinamide adenine dinucleotide synthetase or nicotinamide phosphoribosyl transferase, as z. in EP04077624.7 or WO2006/133827 or PCT/EP07/002433.
  • Plants or plant varieties obtained by methods of plant biotechnology, such as genetic engineering, which can also be treated with the compounds of the general formula (I) according to the invention, have a changed quantity, quality and / or shelf life of the harvested product and / or altered properties of certain components of the harvested product, such as: 1) Transgenic plants that synthesize a modified starch that differ in terms of their chemical-physical properties, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the average chain length, the distribution of the side chains, the viscosity behavior, the gel strength, the starch granule size and/or starch granule morphology compared to the synthesized starch in wild-type plant cells or plants, so that this modified starch is better suited for certain applications.
  • a modified starch that differ in terms of their chemical-physical properties, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the average chain length, the distribution of the side chains
  • transgenic plants synthesizing a modified starch are for example in EP0571427, WO95/004826, EP0719338, WO96/15248, WO96/19581, WO96/27674, WO97/11188, WO97/26362, WO97/32985, WO97/42328 , WO97/44472, WO97/45545, WO98/27212, WO98/40503, WO99/58688, WO99/58690, WO99/58654, WO2000/008184, WO2000/008185, WO2000/28052, WO2000/77229, WO20001/2 /12826, WO2002/1059, WO2003/071860, WO2004/056999, WO2005/030941, WO2005/095632 , WO2006/108702, WO2007/009823, WO2000/22140, WO2006/072603, WO2002/034923, EP06090228.5, EP
  • Transgenic plants that synthesize non-starch carbohydrate polymers, or non-starch carbohydrate polymers whose properties are altered compared to wild-type plants without genetic modification.
  • Examples are plants producing polyfructose, particularly of the inulin and levan types as described in EP0663956, WO96/001904, WO96/021023, WO98/039460 and WO99/024593, plants producing alpha-1,4-glucans , as described in WO95/031553, US2002/031826, US6,284,479, US5,712,107, WO97/047806, WO97/047807, WO97/047808 and WO2000/14249, plants producing alpha-1,6-branched alpha-1,4-glucans as described in WO2000/73422 and plants producing alternan as described in WO2000/ 047727, EP06077301.7, US5,908,975 and EP0728213.
  • Plants or plant varieties obtained by methods of plant biotechnology, such as genetic engineering) which can also be treated with the compounds of the general formula (I) according to the invention are plants such as cotton plants with altered fiber properties.
  • Such plants can be obtained by genetic transformation or by selection from plants containing a mutation conferring such altered fiber properties; these include: a) plants such as cotton plants containing an altered form of cellulose synthase genes as described in WO98/000549, b) plants such as cotton plants containing an altered form of rsw2 or rsw3 homologous nucleic acids as described in WO2004 /053219; c) plants such as cotton plants with increased expression of sucrose phosphate synthase, as described in WO2001/017333; d) plants such as cotton plants with increased expression of sucrose synthase, as described in WO2002/45485; e) Plants such as cotton plants in which the timing of gating of the plasmodesmata at the base of the fiber cell is altered, e.g.
  • plants such as cotton plants with fibers with altered reactivity, e.g. B. by expression of the N-acetylglucosamine transferase gene, including nodC, and of chitin synthase genes, as described in WO2006/136351.
  • Plants or plant varieties obtained by methods of plant biotechnology, such as genetic engineering) which are also treated with the compounds of the general formula (I) according to the invention can be treated are crops such as oilseed rape or related Brassica crops with altered oil composition properties.
  • Such plants can be obtained by genetic transformation or by selection from plants containing a mutation conferring such altered oil properties; these include: a) plants such as rape plants which produce oil with a high oleic acid content, as described for example in US5,969,169, US5,840,946 or US6,323,392 or US6,063,947; b) Plants such as rape plants which produce oil with a low linolenic acid content as described in US6,270828, US6,169,190 or US5,965,755. c) Plants, such as rapeseed, which produce oil with a low saturated fatty acid content, e.g. as described in US5,434,283.
  • Particularly useful transgenic plants which can be treated with the compounds of general formula (I) according to the invention are plants which contain transformation events, or a combination of transformation events, and which are, for example, in the files of various national or regional authorities are listed.
  • Particularly useful transgenic plants which can be treated with the compounds of general formula (I) according to the invention are exemplified by plants having one or more genes which code for one or more toxins are the transgenic plants which are offered under the following trade names: YIELD GARD ⁇ (e.g. corn, cotton, soybeans), KnockOut ⁇ (e.g. corn), BiteGard ⁇ (e.g. corn), BT-Xtra ⁇ (e.g. corn), StarLink ⁇ (e.g.
  • Herbicide tolerant crops to mention are, for example, corn varieties, cotton varieties and soybean varieties sold under the following trade names: Roundup Ready ⁇ (glyphosate tolerance, e.g. corn, cotton, soybean), Liberty Link ⁇ (phosphinotricin tolerance, e.g. canola) , IMI ⁇ (imidazolinone tolerance) and SCS ⁇ (sylphonylurea tolerance), for example corn.
  • Roundup Ready ⁇ glyphosate tolerance, e.g. corn, cotton, soybean
  • Liberty Link ⁇ phosphinotricin tolerance, e.g. canola
  • IMI ⁇ imidazolinone tolerance
  • SCS ⁇ sylphonylurea tolerance
  • the compounds of the formula (I) to be used according to the invention can be converted into customary formulations, such as solutions, emulsions, wettable powders, water-based and oil-based suspensions, Powders, dusts, pastes, soluble powders, soluble granules, scattered granules, suspension emulsion concentrates, natural substances impregnated with active substances, synthetic substances impregnated with active substances, fertilizers and very fine encapsulations in polymeric substances.
  • the compounds of the general formula (I) are used in the form of a spray formulation.
  • the present invention therefore also relates to a spray formulation for increasing the resistance of plants to abiotic stress.
  • a spray formulation is described in more detail below:
  • the formulations for spray application are prepared in a known manner, e.g. by mixing the compounds of the general formula (I) to be used according to the invention with extenders, i.e. liquid solvents and/or solid carriers, if appropriate using surface-active agents, ie emulsifiers and/or dispersants and/or foam-forming agents.
  • customary additives such as customary extenders and solvents or diluents, dyes, wetting agents, dispersants, emulsifiers, defoamers, preservatives, secondary thickeners, adhesives, gibberellins and also water, can optionally also be used.
  • the formulations are produced either in suitable systems or else before or during use.
  • Substances that are suitable for imparting special properties to the agent itself or and/or preparations derived from it (e.g. spray mixtures), such as certain technical properties and/or also special biological properties, can be used as auxiliaries.
  • auxiliaries that can be used are: extenders, solvents and carriers.
  • Suitable extenders are, for example, water, polar and non-polar organic chemical liquids, e.g. from the classes of aromatic and non-aromatic hydrocarbons (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), alcohols and polyols (which may also be substituted, etherified and/or may be esterified), ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly)ethers, simple and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, sulfones and sulfoxides (such as dimethyl sulfoxide).
  • aromatic and non-aromatic hydrocarbons such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes
  • alcohols and polyols which may also be substituted, etherified
  • organic solvents can also be used as auxiliary solvents.
  • Dyes such as inorganic pigments, e.g., iron oxide, titanium oxide, ferrocyanide, and organic dyes such as alizarin, azo and metal phthalocyanine dyes, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc can be used.
  • Suitable wetting agents which can be present in the formulations which can be used according to the invention are all substances which promote wetting and which are customary for the formulation of agrochemical active ingredients.
  • Alkyl naphthalene sulfonates such as diisopropyl or diisobutyl naphthalene sulfonates can preferably be used.
  • Suitable dispersants and/or emulsifiers which can be present in the formulations which can be used according to the invention are all nonionic, anionic and cationic dispersants customary for the formulation of agrochemically active compounds.
  • Nonionic or anionic dispersants or mixtures of nonionic or anionic dispersants can preferably be used.
  • nonionic dispersants are ethylene oxide-propylene oxide block polymers, alkylphenol polyglycol ethers and tristryrylphenol polyglycol ethers and their phosphated or sulfated derivatives.
  • Suitable anionic dispersants are, in particular, lignin sulfonates, polyacrylic acid salts and aryl sulfonate-formaldehyde condensates. All foam-inhibiting substances customary for the formulation of agrochemically active compounds can be present as antifoams in the formulations which can be used according to the invention. Silicone defoamers and magnesium stearate can preferably be used.
  • the gibberellins are known (cf. R. Wegler "Chemistry of plant protection and pest control agents", Vol. 2, Springer Verlag, 1970, pp. 401-412).
  • additives can be fragrances, mineral or vegetable oils, optionally modified, waxes and nutrients (also trace nutrients), such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.
  • Stabilizers such as cold stabilizers, antioxidants, light stabilizers or other agents that improve chemical and/or physical stability can also be present.
  • the formulations generally contain between 0.01 and 98% by weight, preferably between 0.5 and 90% by weight. %, of the compound of general formula (I).
  • the compounds of the general formula (I) according to the invention can be used in commercial formulations and in the use forms prepared from these formulations as a mixture with other active ingredients such as insecticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides, growth-regulating substances, herbicides, safeners, fertilizers or Semiochemicals present. Furthermore, the described positive effect of the compounds of the formula (I) on the plants' own defenses can be supported by additional treatment with insecticidal, fungicidal or bactericidal active ingredients. Preferred times for the application of the compounds of the general formula (I) according to the invention or their salts to increase the resistance to abiotic stress are soil, stem and/or leaf treatments with the permitted application rates.
  • the compounds of the general formula (I) according to the invention or their salts can generally also be used in their commercial formulations and in the use forms prepared from these formulations in mixtures with other active ingredients such as insecticides, attractants, sterilants, acaricides, nematicides, fungicides, bactericides, growth-regulating substances, substances that affect plant maturity, safeners or herbicides.
  • the active ingredients of the general formula (I) can generally also in their commercial formulations and in the use forms prepared from these formulations in mixtures with other active ingredients such as insecticides, attractants, sterilants, acaricides, nematicides, fungicides, bactericides, growth-regulating substances that Plant maturity influencing substances, safeners or herbicides are present.
  • Particularly favorable mixing partners are, for example, the active ingredients of the various classes listed below in groups, without any preference being set based on their order:
  • F1 Inhibitors of nucleic acid synthesis, eg. B. benalaxyl, benalaxyl-M, bupirimate, chiralaxyl, clozylacone, dimethirimol, ethirimol, furalaxyl, hymexazole, metalaxyl, metalaxyl-M, ofurace, oxadixyl, oxolinic acid;
  • F2 Inhibitors of mitosis and cell division, e.g. B.
  • Inhibitors of ATP production e.g. fentin acetate, fentin chloride, fentin hydroxide, silthiofam F7) inhibitors of amino acid and protein biosynthesis, e.g. andoprim, blasticidin-S, cyprodinil, kasugamycin, kasugamycin hydrochloride hydrate, mepanipyrim, pyrimethanil F8) inhibitors of signal transduction, e. B. fenpiclonil, fludioxonil, quinoxyfen F9) Inhibitors of fat and membrane synthesis, z.
  • Inhibitors of ATP production e.g. fentin acetate, fentin chloride, fentin hydroxide, silthiofam F7
  • inhibitors of amino acid and protein biosynthesis e.g. andoprim, blasticidin-S, cyprodinil, kasugamycin, kasugamycin hydrochloride hydrate, mepanipyrim,
  • chlozolinate iprodione, procymidone, vinclozolin, ampropylfos, potassium ampropylfos, edifenphos, iprobefos (IBP), isoprothiolane, pyrazophos, tolclofos-methyl, biphenyl, iodocarb, propamocarb, propamocarb hydrochloride F10) Inhibitors of ergosterol biosynthesis, e.g. B.
  • Insecticides / acaricides / nematicides The active ingredients mentioned here by their "common name” are known and are described, for example, in the pesticide manual ("The Pesticide Manual” 14th Ed., British Crop Protection Council 2006) or can be researched on the Internet (e.g. http://www .alanwood.net/pesticides).
  • Acetylcholinesterase (AChE) inhibitors such as carbamates, e.g.
  • GABA-gated chloride channel antagonists such as cyclodiene-organochlorins, e.g., Chlordane and Endosulfan, or phenylpyrazoles (Fiprole), e.g., Ethiprole and Fipronil.
  • GABA-gated chloride channel antagonists such as cyclodiene-organochlorins, e.g., Chlordane and Endosulfan, or phenylpyrazoles (Fiprole), e.g., Ethiprole and Fipronil.
  • Sodium channel modulators / voltage dependent sodium channel blockers such as pyrethroids e.g.
  • Nicotinergic acetylcholine receptor (nAChR) agonists such as neonicotinoids, e.g., acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid and thiamethoxam or nicotine or sulfoxaflor or flupyradifurone.
  • Nicotinergic acetylcholine receptor (nAChR) allosteric activators such as spinosines, e.g., spinetoram and spinosad.
  • Chloride channel activators such as avermectins/milbemycins, e.g., abamectin, emamectin benzoate, lepimectin and milbemectin.
  • Juvenile hormone mimics such as juvenile hormone analogues, e.g., hydroprene, kinoprene and methoprene, or fenoxycarb or pyriproxyfen.
  • Drugs with unknown or non-specific mechanisms of action such as alkyl halides, e.g., methyl bromide and other alkyl halides; or chloropicrine, or sulfuryl fluoride, or borax, or tartar emetic.
  • Nicotinergic acetylcholine receptor antagonists such as Bensultap, Cartap hydrochloride, Thiocyclam and Thiosultap sodium.
  • Inhibitors of chitin biosynthesis type O such as bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron and triflumuron.
  • Inhibitors of chitin biosynthesis, type 1 such as buprofezin.
  • Ecdysone receptor agonists such as chromafenozide, halofenozide, methoxyfenozide and tebufenozide.
  • Octopaminergic agonists such as amitraz.
  • Complex III electron transport inhibitors such as hydramethylnon or acequinocyl or fluacrypyrim.
  • Complex I electron transport inhibitors for example METI acaricides, e.g., fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad and tolfenpyrad, or Rotenone (Derris).
  • Voltage-gated sodium channel blockers e.g., indoxacarb or metaflumizone.
  • Inhibitors of acetyl-CoA carboxylase such as tetronic and tetramic acid derivatives, e.g., spirobudiclofen, spirodiclofen, spiromesifen and spirotetramat.
  • Complex IV electron transport inhibitors such as phosphines, e.g., aluminum phosphide, calcium phosphide, phosphine and zinc phosphide or cyanide.
  • Complex II electron transport inhibitors such as cyenopyrafen and cyflumetofen.
  • Ryanodine receptor effectors such as diamides, e.g., chlorantraniliproles, cyantraniliproles, flubendiamides and tetrachlorantraniliproles.
  • Other active ingredients with an unknown or ambiguous mechanism of action such as afidopyropene, afoxolaner, azadirachtin, benclothiaz, benzoximate, bifenazate, broflanilide, bromopropylate, quinomethionate, cryolite, cyclaniliprole, cycloxaprid, cyhalodiamide dicloromezotiaz, dicofol, diflovidazine, flometoquine, fluazaindolizine, fluensulfone, flufenerim, Flufenoxystrobin, Flufiprole, Fluhexafone, Fluopyram, Fluralaner, Fluxametamide, Fuf
  • Safeners are preferably selected from the group consisting of: S1) compounds of formula (S1), where the symbols and indices have the following meanings: nA is a natural number from 0 to 5, preferably 0 to 3; RA 1 is halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, nitro or (C 1 -C 4 )-haloalkyl; - WA is an unsubstituted or substituted divalent heterocyclic radical from the group of saturated or aromatic five-membered ring heterocycles having 1 to 3 hetero ring atoms from the group N and O, where at least one N atom and at most one O atom is contained in the ring, preferably one Rest of the group (WA 1 ) to (WA 4 ), mA is 0 or 1; RA 2 is ORA 3 , SRA 3 or NRA 3 RA 4 or a saturated or unsaturated 3- to 7-membered heterocycle having at least one N
  • RB 1 is halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, nitro or (C 1 -C 4 )-haloalkyl
  • nB is a natural number from 0 to 5, preferably 0 to 3
  • RB 2 is ORB 3 , SRB 3 or NRA 3 RB 4 or a saturated one or unsaturated 3- to 7-membered heterocycle having at least one N atom and up to 3 heteroatoms, preferably from the group O and S, which is connected to the carbonyl group in (S2) via the N atom and is unsubstituted or substituted by radicals of the group (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy or optionally substituted phenyl, preferably a radical of the formula OR B 3 , NHR B 4 or N(
  • R C 1 is (C 1 -C 4 )-alkyl, (C 1 -C 4 )-haloalkyl, (C 2 -C 4 )-alkenyl, (C 2 -C 4 )-haloalkenyl, (C 3 -C 7 )-cycloalkyl, preferably dichloromethyl;
  • R C 2 , R C 3 are identical or different hydrogen, (C 1 -C 4 )-alkyl, (C 2 -C 4 )-alkenyl, (C 2 -C 4 )-alkynyl, (C 1 -C 4 )-haloalkyl, (C 2 -C 4 )-haloalkenyl, (C 1 -C 4 )-alkylcarbamoyl-(C 1 -C 4 )-alkyl, (C 2 - C 4 )-alkenylcarbam
  • XD is CH or N;
  • RD 1 is CO-NRD 5 RD 6 or NHCO-RD 7 ;
  • RD 2 is halogen, (C 1 -C 4 )-haloalkyl, (C 1 -C 4 )-haloalkoxy, nitro, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkylsulfonyl, (C 1 -C 4 )-alkoxycarbonyl or (C 1 -C 4 )-alkylcarbonyl;
  • R D 3 is hydrogen, (C 1 -C 4 )-alkyl, (C 2 -C 4 )-alkenyl or (C 2 -C 4 )-alkynyl;
  • R D 4 is
  • the e.g. B. are known from WO-A-97/45016 wherein RD 7 (C 1 -C 6 )-alkyl, (C 3 -C 6 )-cycloalkyl, where the 2 last-mentioned radicals are replaced by vD substituents from the group halogen, (C 1 -C 4 )-alkoxy, (C 1 -C 6 )-haloalkoxy and (C 1 -C 4 )-alkylthio and in the case of cyclic radicals also (C 1 -C 4 )-alkyl and (C 1 -C 4 )-haloalkyl; RD 4 halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, CF 3 ; mD 1 or 2; v D is 0, 1, 2 or 3; and acylsulfamoylbenzoic acid amides,
  • S5 Active ingredients from the class of hydroxyaromatics and aromatic-aliphatic carboxylic acid derivatives (S5), e.g. ethyl 3,4,5-triacetoxybenzoate, 3,5-di-methoxy-4- hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 4-hydroxysalicylic acid, 4-fluorosalicylic acid, 2-hydroxycinnamic acid, 2,4-dichlorocinnamic acid, as described in WO-A-2004/084631, WO-A-2005/015994, WO-A- 2005/016001.
  • S6 Active substances from the class of 1,2-dihydroquinoxalin-2-ones (S6), e.g.
  • R E 1 , R E 2 are independently halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-haloalkyl, (C 1 -C 4 )-alkylamino, di-(C 1 -C 4 )-alkylamino, nitro;
  • AE is COORE 3 or COSRE 4 RE 3
  • R.E 4 are independently hydrogen, (C 1 -C 4 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 4 )-alkynyl, cyanoalkyl, (C 1 -C 4 )-haloalkyl, phenyl, nitrophenyl, benzyl, halobenzyl, pyridinylalkyl and
  • S9 Active substances from the class of 3-(5-tetrazolylcarbonyl)-2-quinolones (S9), e.g. 1,2-dihydro-4-hydroxy-1-ethyl-3-(5-tetrazolylcarbonyl)-2-quinolone (CAS -Reg.Nr.219479-18-2), 1,2-dihydro-4-hydroxy-1-methyl-3-(5-tetrazolyl-carbonyl)-2-quinolone (CAS Reg.Nr.95855-00- 8) as described in WO-A-1999/000020.
  • S9 3-(5-tetrazolylcarbonyl)-2-quinolones
  • S11 Active substances of the type of oxyimino compounds (S11), which are known as seed dressings, such as. B. "Oxabetrinil” ((Z)-1,3-dioxolan-2-ylmethoxyimino(phenyl)acetonitrile) (S11-1) known as a seed dressing safener for millet against damage from metolachlor, "Fluxofenim” (1- (4-Chlorophenyl)-2,2,2-trifluoro-1-ethanone-O-(1,3-dioxolan-2-ylmethyl)-oxime) (S11-2) used as a seed dressing safener for sorghum against damage from metolachlor, and "Cyometrinil” or “CGA-43089” ((Z)-cyanomethoxyimino(phenyl)acetonitrile) (S11-3), which is known as a seed dressing safener for sorghum against damage from metolachlor.
  • S12 Active substances from the class of isothiochromanone (S12), such as methyl [(3-oxo-1H-2-benzothiopyran-4(3H)-ylidene)methoxy]acetate (CAS Reg. No. 205121-04-6 ) (S12-1) and related compounds from WO-A-1998/13361.
  • S12 isothiochromanone
  • S13 One or more compounds from group (S13): "Naphthalic anhydride” (1,8-naphthalenedicarboxylic acid anhydride) (S13-1), known as a seed dressing safener for corn against damage from thiocarbamate herbicides, "Fenclorim” (4.6 -dichloro-2-phenylpyrimidine) (S13-2), known as a safener for pretilachlor in seeded rice, "Flurazole” (benzyl 2-chloro-4-trifluoromethyl-1,3-thiazole-5-carboxylate) (S13 -3) known as a seed dressing safener for millet against damage from alachlor and metolachlor, "CL 304415” (CAS Reg.No.31541-57-8) (4-carboxy-3,4-dihydro-2H- 1- benzopyran-4-acetic acid) (S13-4) from American Cyanamid, which is known as a safener for corn against damage from imidazolin
  • Substances influencing plant maturity are, for example, known active substances which are based on an inhibition of, for example, 1-aminocyclopropane-1-carboxylate synthase, 1-aminocyclopropane-1-carboxylate oxidase and the ethylene receptors, e.g. B. ETR1, ETR2, ERS1, ERS2 or EIN4, can be used, as z. B. in Biotechn. Adv. 2006, 24, 357-367; Bot. Bull. Acad. Sin.199, 40, 1-7 or Plant Growth Reg.1993, 13, 41-46 and the literature cited there.
  • known active substances which are based on an inhibition of, for example, 1-aminocyclopropane-1-carboxylate synthase, 1-aminocyclopropane-1-carboxylate oxidase and the ethylene receptors, e.g. B. ETR1, ETR2, ERS1, ERS2 or EIN4, can be used, as z. B.
  • Known substances that influence plant maturity and which can be combined with the compounds of the general formula (I) include, for example, the following active ingredients (the compounds are either given the "common name” according to the International Organization for Standardization (ISO) or indicated by the chemical name or by the code number) and always include all application forms such as acids, salts, esters and isomers such as stereoisomers and optical isomers.
  • rhizobitoxin 2-amino-ethoxy-vinylglycine (AVG), methoxyvinylglycine (MVG), vinylglycine, aminooxyacetic acid, sinefungin, S-adenosylhomocysteine, 2-keto-4-methylthiobutyrate, (isopropylidene )-aminooxyacetic acid 2-(methoxy)-2-oxoethyl ester, (isopropylidene)-aminooxyacetic acid 2-(hexyloxy)-2-oxoethyl ester, (cyclohexylidene)-aminooxyacetic acid 2-(isopropyloxy)-2-oxoethyl ester, putrescine, spermidine, Spermine, 1,8-diamino-4-aminoethyloctane, L-canalin, daminozide, 1-amin
  • Substances influencing plant health and germination As combination partners for the compounds of the general formula (I) in mixture formulations or in the tank mix, for example, known active substances that influence plant health or germination can be used (the compounds are either identified by the "common name" after of the International Organization for Standardization (ISO) or with the chemical name or with the code number and always include all application forms such as acids, salts, esters and isomers such as stereoisomers and optical isomers): sarcosine, phenylalanine, tryptophan, N'-methyl-1 - phenyl-1-N,N-diethylaminomethanesulfonamide, apio-galacturonanes as described in WO2010017956, 4-oxo-4-[(2-phenylethyl)amino]butanoic acid, 4- ⁇ [2-(1H-indole-3- yl)ethyl]amino ⁇ -4-oxobutanoic acid, 4-[
  • Herbicides or plant growth regulators as combination partners for the compounds of general formula (I) in mixture formulations or in the tank mix are, for example, known active substances which are based on an inhibition of, for example, acetolactate synthase, acetyl-CoA carboxylase, cellulose synthase, enolpyruvylshikimate-3 -phosphate synthase, glutamine synthetase, p-hydroxyphenylpyruvate dioxygenase, phytoene desaturase, photosystem I, photosystem II, protoporphyrinogen oxidase or act as plant growth regulators, such as those from Weed Research 26 (1986) 441-445 or "The Pesticide Manual", 14th edition, The British Crop Protection Council and the Royal Soc.
  • herbicides or plant growth regulators which can be combined with compounds of the general formula (I)
  • the following active ingredients are to be mentioned, for example (the compounds are either identified by the "common name” according to the International Organization for Standardization (ISO) or by the chemical name or denoted by the code number) and always include all application forms such as acids, salts, esters and isomers such as stereoisomers and optical isomers.
  • acetochlor acifluorfen, acifluorfen-methyl, acifluorfen-sodium, aclonifen, alachlor, allidochlor, alloxydim, alloxydim-sodium, ametryn, amicarbazone, amidochlor, amidosulfuron, 4-amino-3- Chloro-6-(4-chloro-2-fluoro-3-methylphenyl)-5-fluoropyridine-2-carboxylic acid, Aminocyclopyrachlor, Aminocyclopyrachlor-potassium, Aminocyclopyrachlor-methyl, Aminopyralid, Aminopyralid- dimethylammonium, Aminopyralid-tripromine, Amitrole, Ammonium sulfamate, Anilofos, Asulam, Asulam Potassium, Asulam Sodium, Atrazine, Azafenidin, Azim
  • Dicamba-biproamine Dicamba-N,N-bis(3-aminopropyl)methylamine, Dicamba- butotyl, Dicamba-choline, Dicamba-Diglycolamine, Dicamba-dimethylammonium, Dicamba- Diethanolaminemmonium, Dicamba-Diethylammonium, Dicamba-isopropylammonium, Dicamba-methyl, dicamba monoethanolamine, dicamba olamine, dicamba potassium, dicamba sodium, dicamba triethanolamine), dichlobenil, 2-(2,4-dichlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, 2 -(2,5-Dichlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, Dichloroprop, Dichloropropbutotyl, Dichloropropdimethylammonium, Dichloropropetexyl, Dichloroprope
  • TCA trifluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzoxazine -6-yl]-3-propyl-2-thioxoimidazolidine-4,5-dione, 2,3,6-TBA, TCA (trichloroacetic acid) and its salts, e.g., TCA-ammonium, TCA-calcium, TCA-ethyl, TCA - Magnesium, TCA Sodium, Tebuthiuron, Tefuryltrione, Tembotrione, Tepraloxydim, Terbacil, Terbucarb, Terbumetone, Terbuthylazine, Terbutryn, Tetflupyrolimet, Thaxtomin, Thenylchlor, Thiazopyr, Thiencarbazone, Thiencarbazone-Methyl, Thifensulfuron, Thife nsulfuron-methyl, thioben
  • the plants were stress treated immediately after the application of the substance.
  • the wood fiber pots were transferred to plastic inserts to prevent them from drying too quickly afterwards.
  • Drought stress was induced by slow drying under the following conditions: "Day”: 14 hours illuminated at ⁇ 26-30°C "Night": 10 hours without illumination at ⁇ 18-20°C.
  • the duration of the respective stress phases mainly depended on the condition of the stressed control plants. It was terminated (by re-watering and transfer to a greenhouse with good growing conditions) as soon as irreversible damage to the stressed control plants was observed. After the end of the stress phase, a 4-7 day recovery phase followed, during which the plants were again kept in the greenhouse under good growth conditions.
  • Table A-2 Table A-3 In Vivo Analysis - Part B Seeds of monocotyledonous and dicotyledonous crops were sown in sandy loam soil in plastic pots, covered with soil or sand and grown in the greenhouse under good growth conditions. The test plants were treated in the early leaf stage (BBCH10 – BBCH13). In order to ensure a uniform water supply before the onset of stress, the planted pots were supplied with water by means of dam irrigation before the substance was applied. The compounds according to the invention were first formulated as wettable powders (WP) or dissolved in a solvent mixture. Further dilution was carried out with water with the addition of 0.2% wetting agent (eg Agrotin).
  • WP wettable powders
  • 0.2% wetting agent eg Agrotin
  • the finished spray mixture was sprayed onto the green parts of the plant with a water application rate of the equivalent of 600 l/ha.
  • the plants were stress treated immediately after the application of the substance. Drought stress was induced by slow drying under the following conditions: "Day”: 14 hours illuminated at ⁇ 26-30°C "Night": 10 hours without illumination at ⁇ 18-20°C.
  • the duration of the respective stress phases mainly depended on the condition of the stressed control plants. It was terminated (by re-watering and transfer to a greenhouse with good growing conditions) as soon as irreversible damage to the stressed control plants was observed. After the end of the stress phase, a 4-7 day recovery phase followed, during which the plants were again kept in the greenhouse under good growth conditions.
  • BRSNS Brassica napus
  • ZEAMX Zea mays
  • TRZAS Triticum aestivum

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Abstract

The invention relates to the use of substituted pyrrolidinones of general formula (I), or their salts, wherein the groups in general formula (I) are defined as indicated in the description, for increasing the stress tolerance of plants with respect to abiotic stress and/or for increasing the plant yield.

Description

Bayer AG Verwendung von substituierten Pyrrolidinonen oder deren Salzen zur Steigerung der Stresstoleranz in Pflanzen. Beschreibung Die Erfindung betrifft die Verwendung von substituierten Pyrrolidinonen oder deren Salzen zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress, sowie zur Steigerung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags. Es ist bekannt, dass bestimmte substituierte Pyrrolidin-2-on-4-carboxamide und Pyrrolidin-2-on-4- essigsäureamide als pharmazeutische Wirkstoffe verwendet werden können, z. B. als Beta- Secretaseinhibitoren (vgl. z. B. WO2009/038412) oder als P2X7-Modulatoren für die Behandlung entzündlicher und neurodegenerativer Erkrankungen (vgl. z.B. WO2009/077559; WO2019/185868; Journal of Medicinal Chemistry (2020), 63(5), 2074-2094). Es ist weiter bekannt, dass bestimmte Pyrrolidinon-substituierte Beta-Oxocarboxamide als PLA2G16-Inhibitoren zur Behandlung von viralen Infektionen eingesetzt werden können (vgl. WO2019/068841). Die Wirkung von bestimmten Pyrrolidinon-substituierten Harnstoffen als Kinaseinhibitoren wird in WO2012/019015 beschrieben. Die Synthese von Pyrrolidin-2-on-5-essigsäureamiden wird in Chemistry – a European Journal, 2017, 23, 7428 und Tetrahedron: Asymmetry, 2004, 15, 3461 beschrieben. Ausgewählte Pyrrolidinon-substituierte Harnstoffe werden als Leitstrukturen zur Identifizierung von TRPV1-Modulatoren (vgl. Future Med. Chem.2015, 7, 243) oder ERK-Inhibitoren (vgl. WO2016/100050) beschrieben. Die Verwendung von bestimmten Pyrrolidin-2-on-4-carboxamiden als Leitstrukturen zur Identifizierung von Antituberkulosewirkstoffen oder von G Protein-gekoppelten Rezeptorkinaseinhibitoren ist ebenfalls beschrieben (Bioorg. Med. Chem.2010, 18, 6914; Bioorg. Med. Chem. Lett.2018, 28, 1507). Die Verwendung von Pyrrolidin-2-on-5-essigsäureamiden, Pyrrolidin-2-on-4-carboxamiden, Pyrrolidin-2- on-4-essigsäureamiden und Pyrrolidin-2-on-4-Harnstoffen gegen abiotischen Stress wird dagegen nicht beschrieben. Die Verwendung ausgewählter Arylsulfonamide als Wuchsregulatoren vor allem zur Beschränkung der Wuchslänge von Reis- und Weizenpflanzen mit dem Ziel der Minimierung des wetterbedingten Umknickens wird in DE 2544859 beschrieben, während die fungizide Wirkung bestimmter N- Cyanoalkylsulfonamide in EP176327A1 beschrieben wird. Es ist außerdem bekannt, dass substituierte N-Sulfonyl-aminoacetonitrile zur Kontrolle von Parasiten in Warmblütern eingesetzt werden können (vg. WO2004/000798). Die Verwendung von 1-(4-Methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4- tetrahydrochinolin-6-yl)methansulfonamid gegen Trockenstress in Arabidopsis thaliana und Soja wird in Proc. Natl. Acad. Sci.2013, 110(29), 12132-12137 beschrieben. Die Verwendung von 1-(4- Methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydrochinolin-6-yl)methansulfonamid zur Steigerung der Stresstoleranz von Pflanzen wird ebenfalls in CN 104170823 beschrieben. Weitere 1-Aryl-N-(2-oxo-1- alkyl-1,2,3,4-tetrahydrochinolin-6-yl)methansulfonamide mit unverzweigter oder verzweigter, aber nicht weiter substituierter Alkylgruppe in der N-Tetrahydrochinolinyleinheit werden in WO2013/148339 beschrieben. In WO2013/148339 wird ebenfalls die agonistische Wirkung der betreffenden Substanzen an Abscisinsäurerezeptoren beschrieben. In WO2013/148339 werden weiterhin (2-Oxo-1,2,3,4- tetrahydrochinolin-6-yl)methansulfonamide mit unsubstituierten N-Cycloalkylresten beansprucht, während in WO2015/155154 die Wirkung von speziell substituierten (2-Oxo-1,2,3,4-tetrahydrochinolin- 6-yl)methansulfonamiden gegen abiotischen Stress sowie die agonistische Wirkung der betreffenden Substanzen an Abscisinsäure-rezeptoren beschrieben wird. In WO2015/049351 wird die Wirkung von Dihydrooxindolylsulfonamiden gegen abiotischen Stress in Pflanzen beschrieben. Die Verwendung von 3-Aminopyrrolidinonsulfonamiden gegen abiotischen Stress oder zur Steigerung des Pflanzenwachstums wird dagegen nicht beschrieben. Es ist bekannt, dass Pflanzen auf natürliche Stressbedingungen, wie beispielsweise Kälte-, Hitze-, Trockenstress (Stress verursacht durch Trockenheit und/oder Wassermangel), Verwundung, Pathogenbefall (Viren, Bakterien, Pilze, Insekten) etc. aber auch auf Herbizide mit spezifischen oder unspezifischen Abwehrmechanismen reagieren können [Pflanzenbiochemie, S.393-462 , Spektrum Akademischer Verlag, Heidelberg, Berlin, Oxford, Hans W. Heldt, 1996.; Biochemistry and Molecular Biology of Plants, S.1102-1203, American Society of Plant Physiologists, Rockville, Maryland, eds. Buchanan, Gruissem, Jones, 2000]. In Pflanzen sind zahlreiche Proteine und die sie codierenden Gene bekannt, die an Abwehrreaktionen gegen abiotischen Stress (z.B. Kälte, Hitze, Trockenheit, Salz, Überflutung) beteiligt sind. Diese gehören teilweise zu Signaltransduktionsketten (z.B. Transkriptionsfaktoren, Kinasen, Phosphatasen) oder bewirken eine physiologische Antwort der Pflanzenzelle (z.B. Ionentransport, Entgiftung reaktiver Sauerstoff-Spezies). Zu den Signalkettengenen der abiotischen Stressreaktion gehören u.a. Transkriptionsfaktoren der Klassen DREB und CBF (Jaglo-Ottosen et al., 1998, Science 280: 104-106). An der Reaktion auf Salzstress sind Phosphatasen vom Typ ATPK und MP2C beteiligt. Ferner wird bei Salzstress häufig die Biosynthese von Osmolyten wie Prolin oder Sucrose aktiviert. Beteiligt sind hier z.B. die Sucrose-Synthase und Prolin-Transporter (Hasegawa et al., 2000, Annu Rev Plant Physiol Plant Mol Biol 51: 463-499). Die Stressabwehr der Pflanzen gegen Kälte und Trockenheit benutzt z.T. die gleichen molekularen Mechanismen. Bekannt ist die Akkumulation von sogenannten Late Embryogenesis Abundant Proteins (LEA-Proteine), zu denen als wichtige Klasse die Dehydrine gehören (Ingram and Bartels, 1996, Annu Rev Plant Physiol Plant Mol Biol 47: 277-403, Close, 1997, Physiol Plant 100: 291-296). Es handelt sich dabei um Chaperone, die Vesikel, Proteine und Membranstrukturen in gestressten Pflanzen stabilisieren (Bray, 1993, Plant Physiol 103: 1035-1040). Außerdem erfolgt häufig eine Induktion von Aldehyd-Deydrogenasen, welche die bei oxidativem Stress entstehenden reaktiven Sauerstoff-Spezies (ROS) entgiften (Kirch et al., 2005, Plant Mol Biol 57: 315-332). Heat Shock Faktoren (HSF) und Heat Shock Proteine (HSP) werden bei Hitzestress aktiviert und spielen hier als Chaperone eine ähnliche Rolle wie die Dehydrine bei Kälte- und Trockenstress (Yu et al., 2005, Mol Cells 19: 328-333). Eine Reihe von pflanzenendogenen Signalstoffen, die in die Stresstoleranz bzw. die Pathogenabwehr involviert sind, sind bereits bekannt. Zu nennen sind hier beispielsweise Salicylsäure, Benzoesäure, Jasmonsäure oder Ethylen [Biochemistry and Molecular Biology of Plants, S.850-929, American Society of Plant Physiologists, Rockville, Maryland, eds. Buchanan, Gruissem, Jones, 2000]. Einige dieser Substanzen oder deren stabile synthetische Derivate und abgeleitete Strukturen sind auch bei externer Applikation auf Pflanzen oder Saatgutbeizung wirksam und aktivieren Abwehrreaktionen, die eine erhöhte Stress- bzw. Pathogentoleranz der Pflanze zur Folge haben [Sembdner, and Parthier, 1993, Ann. Rev. Plant Physiol. Plant Mol. Biol.44: 569-589]. Der Einfluss von pflanzlichen Metaboliten wie z.B. Aminosäuren wie Prolin oder Tryptophan, auf die Toleranz von Kulturpflanzen gegenüber abiotischem Stress ist ebenfalls beschrieben [Godoy et al.2021, Plants 10 (2): 186]. Pyrrolidin-2-on-5- essigsäureamiden, Pyrrolidin-2-on-4-carboxamiden, Pyrrolidin-2-on-4-essigsäureamiden und Pyrrolidin- 2-on-4-Harnstoffen werden in dieser Übersicht allerdings nicht beschrieben. Es ist weiter bekannt, dass chemische Substanzen die Toleranz von Pflanzen gegen abiotischen Stress erhöhen können. Derartige Substanzen werden dabei entweder durch Saatgut-Beizung, durch Blattspritzung oder durch Bodenbehandung appliziert. So wird eine Erhöhung der abiotischen Stresstoleranz von Kulturpflanzen durch Behandlung mit Elicitoren der Systemic Acquired Resistance (SAR) oder Abscisinsäure-Derivaten beschrieben (Schading and Wei, WO2000/28055; Abrams and Gusta, US5201931; Abrams et al, WO97/23441, Churchill et al., 1998, Plant Growth Regul 25: 35-45). Desweiteren wurden Effekte von Wachstumsregulatoren auf die Stresstoleranz von Kulturpflanzen beschrieben (Morrison and Andrews, 1992, J Plant Growth Regul 11: 113-117, RD-259027). In diesem Zusammenhang ist ebenfalls bekannt, dass ein wachstumsregulierendes Naphthylsulfonamid (4-Brom- N-(pyridin-2-ylmethyl)naphthalin-1-sulfonamid) die Keimung von Pflanzensamen in der gleichen Weise wie Abscisinsäure beeinflusst (Park et al. Science 2009, 324, 1068-1071). Weiterhin zeigt eine Naphthylsulfamidocarbonsäure (N-[(4-Brom-1-naphthyl)sulfonyl]-5-methoxynorvalin) eine Wirkungsweise in biochemischen Rezeptortests, die mit 4-Brom-N-(pyridin-2-ylmethyl)naphthalin-1- sulfonamid vergleichbar ist (Melcher et al. Nature Structural & Molecular Biology 2010, 17, 1102- 1108). Außerdem ist bekannt, dass ein weiteres Naphthylsulfonamid, N-(6-aminohexyl)-5- chlornaphthalin-1-sulfonamid, den Calcium-Spiegel in Pflanzen beeinflusst, die einem Kälteschock ausgesetzt wurden (Cholewa et al. Can. J. Botany 1997, 75, 375-382). Auch bei Anwendung von Fungiziden, insbesondere aus der Gruppe der Strobilurine oder der Succinat Dehydrogenase Inhibitoren werden ähnliche Effekte beobachtet, die häufig auch mit einer Ertragssteigerung einhergehen (Draber et al., DE 3534948, Bartlett et al., 2002, Pest Manag Sci 60: 309). Es ist ebenfalls bekannt, dass das Herbizid Glyphosat in niedriger Dosierung das Wachstum einiger Pflanzenarten stimuliert (Cedergreen, Env. Pollution 2008, 156, 1099). Bei osmotischem Stress ist eine Schutzwirkung durch Applikation von Osmolyten wie z.B. Glycinbetain oder deren biochemischen Vorstufen, z.B. Cholin-Derivate beobachtet worden (Chen et al., 2000, Plant Cell Environ 23: 609-618, Bergmann et al., DE 4103253). Auch die Wirkung von Antioxidantien wie z.B Naphthole und Xanthine zur Erhöhung der abiotischen Stresstoleranz in Pflanzen wurde bereits beschrieben (Bergmann et al., DD 277832, Bergmann et al., DD 277835). Die molekularen Ursachen der Anti-Stress-Wirkung dieser Substanzen sind jedoch weitgehend unbekannt. Es ist weiter bekannt, dass die Toleranz von Pflanzen gegenüber abiotischem Stress durch eine Modifikation der Aktivität von endogenen Poly-ADP-ribose Polymerasen (PARP) oder Poly-(ADP- ribose) glycohydrolasen (PARG) erhöht werden kann (de Block et al., The Plant Journal, 2004, 41, 95; Levine et al., FEBS Lett.1998, 440, 1; WO00/04173; WO2004/090140). Somit ist bekannt, dass Pflanzen über mehrere endogene Reaktionsmechanismen verfügen, die eine wirksame Abwehr gegenüber verschiedensten Schadorganismen und/oder natürlichem abiotischem Stress bewirken können. Da sich die ökologischen und ökonomischen Anforderungen an moderne Pflanzenbehandlungsmittel laufend erhöhen, beispielsweise was deren Toxizität, Selektivität, Aufwandmenge, Rückstandsbildung und günstige Herstellbarkeit angeht, besteht die ständige Aufgabe, neue Pflanzenbehandlungsmittel zu entwickeln, die zumindest in Teilbereichen Vorteile gegenüber den bekannten aufweisen. Daher bestand die Aufgabe der vorliegenden Erfindung darin, Verbindungen bereitzustellen, die die Toleranz gegenüber abiotischem Stress in Pflanzen weiter erhöhen, eine Stärkung des Pflanzenwachstums bewirken und/oder zur Erhöhung des Pflanzenertrags beitragen. In diesem Zusammenhang wird unter Toleranz gegenüber abiotischem Stress beispielsweise die Toleranz gegenüber Kälte-, Hitze-, Trockenstress (Stress verursacht durch Trockenheit und/oder Wassermangel), Salzen und Überflutung verstanden. Überraschenderweise wurde nun gefunden, dass substituierte Pyrrolidinone zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress, sowie zur Steigerung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags verwendet werden können. Gegenstand der vorliegenden Erfindung ist demnach die Verwendung substituierter Pyrrolidinone der allgemeinen Formel (I) oder deren Salze zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress, sowie zur Steigerung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags,
Figure imgf000006_0001
worin R1 für Wasserstoff, NR30R31, OR32, S(O)mR33, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C2-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)- Alkyl, R30R31N-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, (C3-C10)- Cycloalkyl-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32(O=)C-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32 steht, m für 0, 1, 2 steht, R3 und R4 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, NR30R31, OR32, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl stehen, R3 und R5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R2 und R7 nicht gleichzeitig H sind und dass R7 für H steht, wenn R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R2 für H steht, wenn R7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht,
Figure imgf000007_0001
R8, R9, R10, R15, R18, R19, R20 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2--C8)-Alkinyl, Aryl-(C1-C8)-Alkyl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, S(O)mR33, R32(O=)C-(C1-C8)-Alkyl, C(O=)R32, (C1-C8)-Alkyloxycarbonyl, Aryl-(C1-C8)-Alkyloxycarbonyl stehen, R8 und R9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11, R12, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, OR32 stehen, R16, R17, R21, R22 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stehen, R23, R24 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl- (C1-C8)-Alkyl, C(O=)R32, (C1-C8)-Alkyloxycarbonyl, Aryl-(C1-C8)-Alkyloxycarbonyl stehen, R25, R28, R29 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl-(C1-C8)-Alkyl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl stehen, R26, R27 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)- Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1-C8)-Alkylthio-(C1-C8)- alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl- (C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C8)-Alkoxycarbonyl, Bis-[(C1- C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1- C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl, Heteroaryl-(C1-C8)- alkoxycarbonyl, (C2-C8)-Alkenyloxycarbonyl, (C2-C8)-Alkinyloxycarbonyl, Heterocyclyl- (C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl- (C1-C8)-alkyl, (C2-C8)-Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl- (C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)- alkoxycarbonyl-(C1-C8)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)- alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)-Alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, Aryl, Aryl- (C1-C8)-alkyl, Aryl-(C1-C8)-alkoxy-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)- Cycloalkyl-(C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)- alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)- alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl- amino-(C2-C6)-alkyl, Aryl-(C1-C8)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C8)-alkyl, Hydroxycarbonyl-(C1-C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)- Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis- (aryl)silyl-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)- Cycloalkylcarbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy- (C1-C8)-alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, Aryloxy-(C1-C8)-alkyl, Heteroaryloxy- (C1-C8)-alkyl, Heterocyclyloxy-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl, (C1-C8)- Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)- Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)- alkoxycarbonyl-(C1-C8)-alkyl steht, R33 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)- alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl- (C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino, (C1-C8)-Alkyl-amino, Aryl-(C1-C8)- amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C8)-alkyl]amino; Heteroaryl-(C1-C8)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl-[(C1-C8)-alkyl]amino; Hetercyclyl-(C1-C8)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C8)-alkyl]amino; (C3-C8)-Cycloalkyl- amino, (C3-C8)-Cycloalkyl-[(C1-C8)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R34 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, NR30R31, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, S(O)mR33 steht, R35 für Wasserstoff, NR30R31, OR32, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl- (C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, S(O)mR33, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m- (C1-C8)-alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht, R36 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)- Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)- Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O-(C1-C8)-Alkyl, R30R31N- (C1-C8)-Alkyl steht, R37 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C2-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, Heteroaryloxy-(C1-C8)-Alkyl, Aryloxy-(C1-C8)- Alkyl, Heterocyclyloxy-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, R32O(O)C- (C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R33S(O)m- (C1-C8)-alkyl, R32(O=)C-(C1-C8)-Alkyl steht und R38 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)- Alkyl steht. Die Verbindungen der allgemeinen Formel (I) können durch Anlagerung einer geeigneten anorganischen oder organischen Säure, wie beispielsweise Mineralsäuren, wie beispielsweise HCl, HBr, H2SO4, H3PO4 oder HNO3, oder organische Säuren, z. B. Carbonsäuren, wie Ameisensäure, Essigsäure, Propionsäure, Oxalsäure, Milchsäure oder Salicylsäure oder Sulfonsäuren, wie zum Beispiel p- Toluolsulfonsäure, an eine basische Gruppe, wie z.B. Amino, Alkylamino, Dialkylamino, Piperidino, Morpholino oder Pyridino, Salze bilden. Diese Salze enthalten dann die konjugierte Base der Säure als Anion. Geeignete Substituenten, die in deprotonierter Form, wie z.B. Sulfonsäuren, bestimmte Sulfonsäureamide oder Carbonsäuren, vorliegen, können innere Salze mit ihrerseits protonierbaren Gruppen, wie Aminogruppen bilden. Salzbildung kann auch durch Einwirkung einer Base auf Verbindungen der allgemeinen Formel (I) erfolgen. Geeignete Basen sind beispielsweise organische Amine, wie Trialkylamine, Morpholin, Piperidin und Pyridin sowie Ammonium-, Alkali- oder Erdalkalimetallhydroxide, -carbonate und -hydrogencarbonate, insbesondere Natrium- und Kaliumhydroxid, Natrium- und Kaliumcarbonat und Natrium- und Kaliumhydrogencarbonat. Diese Salze sind Verbindungen, in denen der acide Wasserstoff durch ein für die Landwirtschaft geeignetes Kation ersetzt wird, beispielsweise Metallsalze, insbesondere Alkalimetall-salze oder Erdalkalimetallsalze, insbesondere Natrium- und Kaliumsalze, oder auch Ammoniumsalze, Salze mit organischen Aminen oder quartäre Ammoniumsalze, zum Beispiel mit Kationen der Formel [NRaRbRcRd]+, worin Ra bis Rd jeweils unabhängig voneinander einen organischen Rest, insbesondere Alkyl, Aryl, Aralkyl oder Alkylaryl darstellen. Infrage kommen auch Alkylsulfonium- und Alkylsulfoxoniumsalze, wie (C1-C4)-Trialkylsulfonium- und (C1-C4)-Trialkylsulfoxoniumsalze. Im Folgenden werden die erfindungsgemäß verwendeten Verbindungen der Formel (I) und ihre Salze "Verbindungen der allgemeinen Formel (I)" bezeichnet. Bevorzugter Erfindungsgegenstand ist die Verwendung von Verbindungen der allgemeinen Formel (I), worin R1 für Wasserstoff, NR30R31, OR32, S(O)mR33, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C2-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)- Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, Aryl, Aryl-(C1-C7)-Alkyl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)- Alkyl, R30R31N-(C1-C7)-Alkyl, R32O(O)C-(C1-C7)-Alkyl, R30R31N(O)C-(C1-C7)-Alkyl, (C3-C10)- Cycloalkyl-(C1-C7)-Alkyl, R33S(O)m-(C1-C7)-alkyl, R32(O=)C-(C1-C7)-Alkyl, C(=O)R32, C(=O)OR32 steht, m für 0, 1, 2 steht, R3 und R4 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C1-C10)-Haloalkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)-Alkyl stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)-Alkyl, NR30R31, OR32, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl stehen, R3 und R5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R2 und R7 nicht gleichzeitig H sind und dass R7 für H steht, wenn R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R2 für H steht, wenn R7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht, Bayer AG Use of substituted pyrrolidinones or their salts to increase stress tolerance in plants. Description The invention relates to the use of substituted pyrrolidinones or salts thereof to increase the stress tolerance in plants to abiotic stress and to increase plant growth and/or to increase plant yield. It is known that certain substituted pyrrolidin-2-one-4-carboxamides and pyrrolidin-2-one-4-acetic acid amides can be used as active pharmaceutical ingredients, e.g. B. as beta-secretase inhibitors (cf. e.g. WO2009/038412) or as P2X7 modulators for the treatment of inflammatory and neurodegenerative diseases (cf. e.g. WO2009/077559; WO2019/185868; Journal of Medicinal Chemistry (2020), 63 (5), 2074-2094). It is also known that certain pyrrolidinone-substituted beta-oxocarboxamides can be used as PLA2G16 inhibitors for the treatment of viral infections (cf. WO2019/068841). The effect of certain pyrrolidinone-substituted ureas as kinase inhibitors is described in WO2012/019015. The synthesis of pyrrolidin-2-one-5-acetic acid amides is described in Chemistry - a European Journal, 2017, 23, 7428 and Tetrahedron: Asymmetry, 2004, 15, 3461. Selected pyrrolidinone-substituted ureas are described as lead structures for identifying TRPV1 modulators (cf. Future Med. Chem.2015, 7, 243) or ERK inhibitors (cf. WO2016/100050). The use of certain pyrrolidin-2-one-4-carboxamides as lead structures for identifying antituberculosis drugs or G protein-coupled receptor kinase inhibitors has also been described (Bioorg. Med. Chem.2010, 18, 6914; Bioorg. Med. Chem. Lett. 2018, 28, 1507). In contrast, the use of pyrrolidin-2-one-5-acetic acid amides, pyrrolidin-2-one-4-carboxamides, pyrrolidin-2-one-4-acetic acid amides and pyrrolidin-2-one-4-ureas against abiotic stress is not described. The use of selected arylsulfonamides as growth regulators, especially for limiting the growth length of rice and wheat plants with the aim of minimizing weather-related buckling, is described in DE 2544859, while the fungicidal action of certain N-cyanoalkylsulfonamides is described in EP176327A1. It is also known that substituted N-sulfonyl-aminoacetonitriles can be used to control parasites in warm-blooded animals (see WO2004/000798). The use of 1-(4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4- tetrahydroquinolin-6-yl)methanesulfonamide against drought stress in Arabidopsis thaliana and soya is described in Proc. national Acad. Sci. 2013, 110(29), 12132-12137. The use of 1-(4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide to increase the stress tolerance of plants is also described in CN 104170823. Further 1-aryl-N-(2-oxo-1-alkyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamides with unbranched or branched but not further substituted alkyl group in the N-tetrahydroquinolinyl unit are described in WO2013/ 148339 described. WO2013/148339 also describes the agonistic effect of the relevant substances on abscisic acid receptors. WO2013/148339 also claims (2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamides with unsubstituted N-cycloalkyl radicals, while WO2015/155154 examines the effect of specially substituted (2-oxo-1, 2,3,4-tetrahydroquinolin-6-yl)methanesulfonamides against abiotic stress and the agonistic effect of the substances in question on abscisic acid receptors is described. WO2015/049351 describes the effect of dihydrooxindolylsulfonamides against abiotic stress in plants. In contrast, the use of 3-aminopyrrolidinone sulfonamides to combat abiotic stress or to increase plant growth is not described. It is known that plants react to natural stress conditions, such as cold, heat, drought stress (stress caused by drought and/or lack of water), wounding, pathogen infestation (viruses, bacteria, fungi, insects), etc., but also to herbicides with specific or non-specific defense mechanisms [plant biochemistry, p.393-462, Spektrum Akademischer Verlag, Heidelberg, Berlin, Oxford, Hans W. Heldt, 1996.; Biochemistry and Molecular Biology of Plants, pp. 1102-1203, American Society of Plant Physiologists, Rockville, Maryland, eds. Buchanan, Gruissem, Jones, 2000]. Numerous proteins and the genes encoding them are known in plants to be involved in defense reactions against abiotic stresses (eg cold, heat, drought, salt, flooding). Some of these belong to signal transduction chains (eg transcription factors, kinases, phosphatases) or cause a physiological response in the plant cell (eg ion transport, detoxification of reactive oxygen species). The signal chain genes of the abiotic stress response include, inter alia, transcription factors of the classes DREB and CBF (Jaglo-Ottosen et al., 1998, Science 280: 104-106). ATPK and MP2C type phosphatases are involved in the response to salt stress. Furthermore, salt stress often activates the biosynthesis of osmolytes such as proline or sucrose. Sucrose synthase and proline transporters, for example, are involved here (Hasegawa et al., 2000, Annu Rev Plant Physiol Plant Mol Biol 51: 463-499). The plants' defense against stress against cold and drought partly uses the same molecular mechanisms. The accumulation of so-called Late Embryogenesis Abundant Proteins (LEA proteins) is known, to which the dehydrins belong as an important class (Ingram and Bartels, 1996, Annu Rev Plant Physiol Plant Mol Biol 47: 277-403, Close, 1997, Physiol Plants 100: 291-296). These are chaperones that stabilize vesicles, proteins and membrane structures in stressed plants (Bray, 1993, Plant Physiol 103: 1035-1040). In addition, there is often an induction of aldehyde dehydrogenases, which detoxify the reactive oxygen species (ROS) that arise in the event of oxidative stress (Kirch et al., 2005, Plant Mol Biol 57: 315-332). Heat shock factors (HSF) and heat shock proteins (HSP) are activated during heat stress and, as chaperones, play a role similar to that of dehydrins during cold and drought stress (Yu et al., 2005, Mol Cells 19: 328-333). A number of plant-endogenous signaling substances that are involved in stress tolerance and pathogen defense are already known. Mention may be made here, for example, of salicylic acid, benzoic acid, jasmonic acid or ethylene [Biochemistry and Molecular Biology of Plants, pp. 850-929, American Society of Plant Physiologists, Rockville, Maryland, eds. Buchanan, Gruissem, Jones, 2000]. Some of these substances or their stable synthetic derivatives and derived structures are also effective when applied externally to plants or seed dressing and activate defense reactions that result in increased stress or pathogen tolerance of the plant [Sembdner, and Parthier, 1993, Ann. Rev. Plant Physiol. Plant Mol. Biol. 44: 569-589]. The influence of plant metabolites such as amino acids such as proline or tryptophan on the tolerance of crop plants to abiotic stress has also been described [Godoy et al.2021, Plants 10 (2): 186]. However, pyrrolidin-2-one-5-acetamides, pyrrolidin-2-one-4-carboxamides, pyrrolidin-2-one-4-acetamides and pyrrolidin-2-one-4-ureas are not described in this overview. It is also known that chemical substances can increase the tolerance of plants to abiotic stress. Such substances are applied either by seed dressing, by foliar spraying or by treating the soil. An increase in the abiotic stress tolerance of crop plants by treatment with elicitors of systemic acquired resistance (SAR) or abscisic acid derivatives is described (Schading and Wei, WO2000/28055; Abrams and Gusta, US5201931; Abrams et al, WO97/23441, Churchill et al., 1998, Plant Growth Reg. 25:35-45). Furthermore, effects of growth regulators on the stress tolerance of crop plants have been described (Morrison and Andrews, 1992, J Plant Growth Regul 11: 113-117, RD-259027). In this context, it is also known that a growth-regulating naphthylsulfonamide (4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide) affects the germination of plant seeds in the same way as abscisic acid (Park et al. Science 2009, 324, 1068-1071). Furthermore, a naphthylsulfamidocarboxylic acid (N-[(4-bromo-1-naphthyl)sulfonyl]-5-methoxynorvaline) shows a mode of action in biochemical receptor tests that is comparable to 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide is comparable (Melcher et al. Nature Structural & Molecular Biology 2010, 17, 1102-1108). It is also known that another naphthylsulfonamide, N-(6-aminohexyl)-5- chloronaphthalene-1-sulfonamide affecting calcium levels in plants exposed to cold shock (Cholewa et al. Can. J. Botany 1997, 75, 375-382). Similar effects are also observed when using fungicides, especially from the group of strobilurins or succinate dehydrogenase inhibitors, which are often associated with an increase in yield (Draber et al., DE 3534948, Bartlett et al., 2002, Pest Manag Sci 60: 309). It is also known that the herbicide glyphosate at low doses stimulates the growth of some plant species (Cedergreen, Env. Pollution 2008, 156, 1099). In the case of osmotic stress, a protective effect through the application of osmolytes such as glycine betaine or their biochemical precursors, eg choline derivatives, has been observed (Chen et al., 2000, Plant Cell Environ 23: 609-618, Bergmann et al., DE 4103253). The effect of antioxidants such as naphthols and xanthines on increasing abiotic stress tolerance in plants has already been described (Bergmann et al., DD 277832, Bergmann et al., DD 277835). However, the molecular causes of the anti-stress effect of these substances are largely unknown. It is also known that the tolerance of plants to abiotic stress can be increased by modifying the activity of endogenous poly-ADP-ribose polymerases (PARP) or poly-(ADP-ribose) glycohydrolases (PARG) (de Block et al. , The Plant Journal, 2004, 41, 95; Levine et al., FEBS Lett.1998, 440, 1; WO00/04173; WO2004/090140). It is thus known that plants have several endogenous reaction mechanisms that can bring about an effective defense against a wide variety of harmful organisms and/or natural abiotic stress. Since the ecological and economic demands on modern plant treatment products are constantly increasing, for example in terms of their toxicity, selectivity, application rate, residue formation and cheap manufacturability, there is a constant task of developing new plant treatment products that have advantages over the known ones, at least in some areas. The object of the present invention was therefore to provide compounds which further increase the tolerance to abiotic stress in plants, cause plant growth to be strengthened and/or contribute to increasing plant yield. In this context, tolerance to abiotic stress is understood to mean, for example, tolerance to cold, heat, drought stress (stress caused by drought and/or lack of water), salts and flooding. Surprisingly, it has now been found that substituted pyrrolidinones can be used to increase the stress tolerance in plants to abiotic stress and to increase plant growth and/or to increase plant yield. The subject matter of the present invention is therefore the use of substituted pyrrolidinones of the general formula (I) or salts thereof to increase stress tolerance in plants to abiotic stress, and to increase plant growth and/or to increase plant yield,
Figure imgf000006_0001
wherein R 1 is hydrogen, NR 30 R 31 , OR 32 , S(O) m R 33 , (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )- Alkynyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 )haloalkenyl, (C 2 -C 8 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )halocycloalkenyl, aryl, aryl-(C 1 -C 8 )alkyl, heteroaryl, heteroaryl-(C 1 -C 8 )alkyl, Heterocyclyl, heterocyclyl-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-alkyl, R 30 R 31 N-(C 1 -C 8 )-alkyl, R 32 O(O) C-(C 1 -C 8 )alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )- alkyl, R 33 S(O)m-(C 1 -C 8 )alkyl, R 32 (O=)C-(C 1 -C 8 )alkyl, C(=O)R 32 , C(=O )OR 32 , m is 0, 1, 2, R 3 and R 4 are independently hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 1 -C 10 )haloalkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 )alkyl, aryl, heteroaryl, Heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 ) -alkyl, R 32 O-(C 1 -C 8 )-alkyl, R 30 R 31 N-(C 1 -C 8 )-alkyl, R 5 , R 6 are independently hydrogen, (C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyl, (C 1 -C 10 )-haloalkyl, (C 3 -C 10 )-cycloalkyl, aryl-(C 1 -C 8 )-alkyl, aryl, heteroaryl, Heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 N-(C 1 - C 8 )-alkyl, NR 30 R 31 , OR 32 , (C 3 -C 10 )-cycloalkyl-(C 1 -C 8 )-alkyl, R 3 and R 5 with the carbon atoms to which they are attached, form a fully saturated or partially saturated 5 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R 2 represents hydrogen and one of the following groups G-1 to G-2, where an arrow represents a bond to the pyrrolidinone ring in the general formula (I), R 7 represents hydrogen and one of the following groups G-1 to G- 15, wherein an arrow represents a bond to the pyrrolidinone ring in the general formula (I), with the proviso that R 2 and R 7 are not H at the same time and that R 7 represents H when R 2 represents one of the following groups G-1 to G-2, and that R 2 is H when R 7 is one of the following groups G-1 to G-15,
Figure imgf000007_0001
R 8 , R 9 , R 10 , R 15 , R 18 , R 19 , R 20 independently of one another are hydrogen, (C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyl, (C 2 -- C 8 ) alkynyl, aryl (C 1 -C 8 ) alkyl, heteroaryl (C 1 -C 8 ) alkyl, heterocyclyl (C 1 -C 8 ) alkyl, R 32 O-(C 1 - C 8 )alkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, S(O)m R 33 , R 32 (O=)C-(C 1 -C 8 )alkyl , C(O=)R 32 , (C 1 -C 8 )alkyloxycarbonyl, aryl-(C 1 -C 8 )alkyloxycarbonyl, R 8 and R 9 with the nitrogen atoms to which they are attached a fully saturated one or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 5 to 10-membered monocyclic or bicyclic ring, R 11 , R 12 , R 13 , R 14 independently of one another are hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 - C 10 )haloalkyl, (C 3 -C 10 )cycloalkyl, aryl(C 1 -C 8 )alkyl, aryl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 N-(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl-(C C1 -C8 ) -alkyl , C(=O)R32 , C(=O) OR32 , C(=O) NR30 R31 , R32 O(O)C-( C1 -C8 ) - Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-alkyl, OR 32 , R 16 , R 17 , R 21 , R 22 independently represent hydrogen, (C 1 -C 8 )- Alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 10 )haloalkyl, (C 3 -C 10 )cycloalkyl, aryl-(C 1 -C 8 ). )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 8 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-alkyl, R 30 R 31 N-(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 23 , R 24 independently represent Hydrogen, (C 1 -C 8 )alkyl, (C 1 -C 10 )haloalkyl, (C 3 -C 10 )cycloalkyl, aryl-(C 1 -C 8 )alkyl, aryl, heteroaryl, heteroaryl (C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 N-(C 1 -C 8 )-alkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )-alkyl, C(O=)R 32 , (C 1 -C 8 )-alkyloxycarbonyl, aryl-(C 1 -C 8 ). )-alkyloxycarbonyl, R 25 , R 28 , R 29 are independently hydrogen, (C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyl, (C 2 -C 8 )-alkynyl, aryl- (C 1 -C 8 )alkyl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, (C C 3 -C 10 )-cycloalkyl-(C 1 -C 8 )-alkyl, R 32 (O=)C-(C 1 -C 8 )-alkyl, R 26 , R 27 independently of one another represent hydrogen, (C 1 -C 8 )alkyl, (C 1 -C 10 )haloalkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, aryl-( C 1 -C 8 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 8 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )-alkyl, R 30 and R 31 independently of one another hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )cyanoalkyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 )haloalkenyl, (C 3 -C 8 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C C 10 )cycloalkenyl, (C 4 -C 10 )halocycloalkenyl, (C 1 -C 8 )alkoxy(C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkoxy(C 1 -C 12 ). 8 )alkyl, (C 1 -C 8 )alkylthio-(C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkylthio-(C 1 -C 8 )alkyl, (C 1 -C 8 )alkyl 8 )-Alkoxy(C 1 -C 8 )haloalkyl, aryl, aryl(C 1 -C 8 )alkyl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, (C 3 -C 8 ) -cycloalkyl-(C 1 -C 8 )alkyl, (C 4 -C 10 )-cycloalkenyl-(C 1 -C 8 )alkyl, COR 32 , SO 2 R 33 , heterocyclyl, (C 1 -C 8 ) -alkoxycarbonyl, bis[(C 1 -C 8 )alkyl]aminocarbonyl-(C 1 -C 8 )alkyl, (C 1 -C 8 )alkylaminocarbonyl-(C 1 -C 8 )alkyl, aryl(C 1 -C 8 )alkylaminocarbonyl(C 1 -C 8 )alkyl, aryl(C 1 -C 8 ) alkoxycarbonyl , heteroaryl (C 1 -C 8 )alkoxycarbonyl, (C C 2 -C 8 ) alkene yloxycarbonyl, (C 2 -C 8 )alkynyloxycarbonyl, heterocyclyl-(C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 )alkyl, (C 2 -C 8 ). )-alkenyloxycarbonyl- (C 1 -C 8 )alkyl, (C 2 -C 8 )alkynyloxycarbonyl-(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 )- alkyl, heteroaryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, heterocyclyl-(C 1 -C 8 ) -alkoxycarbonyl-(C1-C8)-alkyl , or R 30 and R 31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R 32 is hydrogen, (C 1 -C 8 )- alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )cyanoalkyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 )- Haloalkenyl, (C 3 -C 8 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )- Halocycloalkenyl, (C 1 -C 8 )alkoxy(C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkoxy(C 1 -C 8 )alkyl, (C 1 -C 8 )- Alkoxy-(C 1 -C 8 )haloalkyl, (C 1 -C 8 )alkoxy-(C 1 -C 8 )alkoxy-(C 1 -C 8 )alkyl, (C 1 - C 8 ) alkoxy (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl, (C 1 -C 8 ) alkoxy (C 1 - C 8 alkoxy-(C 1 -C 8 )alkoxy-(C 1 -C 8 )alkoxy-(C 1 -C 8 )alkyl, aryl, aryl-(C 1 -C 8 )alkyl, Aryl(C 1 -C 8 )alkoxy(C 1 -C 8 )alkyl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl(C 1 - C 8 alkyl, (C 4 -C 10 )cycloalkenyl(C 1 -C 8 )alkyl, bis[(C 1 -C 8 )alkyl]aminocarbonyl(C 1 -C 8 )alkyl , (C 1 -C 8 )alkylaminocarbonyl-(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 )alkylaminocarbonyl-(C 1 -C 8 )alkyl, bis[ (C 1 -C 8 )alkyl]amino-(C 2 -C 6 )alkyl, (C 1 -C 8 )alkylamino-(C 2 -C 6 )alkyl, aryl-(C 1 - C8 alkylamino-(C2 -C6 )alkyl, R33 (O)m S-(C1 -C8 ) alkyl , hydroxycarbonyl-( C1 -C8 ) alkyl, heterocyclyl, heterocyclyl -(C 1 -C 8 )alkyl, tris[(C 1 -C 8 )alkyl]silyl-(C 1 -C 8 )alkyl, bis[(C 1 -C 8 )alkyl]( aryl)silyl(C 1 -C 8 )alkyl, [(C 1 -C 8 )alkyl]bis(aryl)silyl(C 1 -C 8 )alkyl, (C 1 -C 8 )- alkylcarbonyloxy-(C 1 -C 8 )alkyl, (C 3 -C 8 )-cycloalkylcarbonyloxy(C 1 -C 8 )alkyl, arylcarbonyloxy(C 1 -C 8 )alkyl, heteroarylcarbonyloxy(C 1 -C 8 )alkyl, heterocyclylcarbonyloxy(C 1 -C 8 )alkyl , aryloxy(C 1 -C 8 )alkyl, heteroaryloxy(C 1 -C 8 )alkyl, heterocyclyloxy(C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxycarbonyl, (C 1 -C 8 )- alkoxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyloxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkynyloxycarbonyl-(C 1 -C 8 )alkyl, aryl(C 1 -C 8 )alkoxycarbonyl(C 1 -C 8 )alkyl, heteroaryl(C 1 -C 8 )alkoxycarbonyl(C 1 -C 8 )alkyl , heterocyclyl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl , R 33 represents hydrogen, (C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyl, ( C 2 -C 8 ) alkynyl, (C 1 -C 8 ) cyanoalkyl, (C 1 -C 10 ) haloalkyl, (C 2 -C 8 ) haloalkenyl, (C 3 -C 8 ) haloalkynyl, ( C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )halocycloalkenyl, (C 1 -C 8 )alkoxy-( C 1 -C 8 )-alkyl, (C 1 -C 8 )-alkoxy-(C 1 -C 8 )-haloalkyl, aryl, aryl-( C 1 -C 8 )alkyl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl(C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 8 )alkyl 8 )-alkyl, (C 4 -C 10 )-cycloalkenyl-(C 1 -C 8 )-alkyl, bis[(C 1 -C 8 )-alkyl]amino, (C 1 -C 8 )-alkyl- amino, aryl-(C 1 -C 8 )- amino, aryl(C 1 -C 6 )alkylamino, aryl[(C 1 -C 8 )alkyl]amino; heteroaryl(C 1 -C 8 )amino, heteroaryl(C 1 -C 6 )alkylamino, heteroaryl[(C 1 -C 8 )alkyl]amino; heterocyclyl(C 1 -C 8 )amino, heterocyclyl(C 1 -C 6 )alkylamino, heterocyclyl[(C 1 -C 8 )alkyl]amino; (C 3 -C 8 )cycloalkylamino, (C 3 -C 8 )cycloalkyl[(C 1 -C 8 )alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R 34 is hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, aryl-(C 1 -C 8 )alkyl, aryl, heteroaryl, heteroaryl-(C C 1 -C 8 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-alkyl, R 30 R 31 N-(C 1 -C 8 )- alkyl, NR 30 R 31 , (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, S(O)mR 33 represents, R 35 represents hydrogen, NR 30 R 31 , OR 32 , (C C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, aryl, aryl-(C 1 -C 8 )alkyl, heteroaryl, heteroaryl-(C 1 - C 8 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 ). )-cycloalkyl-(C 1 -C 8 )-alkyl, S(O)m R 33 , R 32 (O=)C-(C 1 -C 8 )-alkyl, R 32 O(O)C-(C 1 -C 8 )-alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-alkyl, R 33 S(O)m-(C 1 -C 8 )-alkyl, R 32 O-( C 1 -C 8 )alkyl, R 30 R 31 is N-(C 1 -C 8 )alkyl, R 36 is hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl , (C 2 -C 8 )alkynyl, aryl, aryl(C 1 -C 8 )alkyl, heteroaryl, heteroaryl(C 1 -C 8 )alk yl, heterocyclyl, heterocyclyl-(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, R 32 (O =)C-(C 1 -C 8 )-alkyl, R 32 O(O)C-(C 1 -C 8 )- alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )- alkyl, R 33 is S(O)m-(C 1 -C 8 )alkyl, R 32 is O-(C 1 -C 8 )alkyl, R 30 R 31 is N-(C 1 -C 8 )alkyl , R 37 is (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 ). )haloalkenyl, (C 2 -C 8 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 ). )-halocycloalkenyl, aryl, aryl(C 1 -C 8 )alkyl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, heteroaryloxy(C C 1 -C 8 )alkyl, aryloxy(C 1 -C 8 )alkyl, heterocyclyloxy(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 N-(C 1 -C 8 )alkyl, R 32 O(O)C-(C 1 -C 8 )alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, R 33 S(O) m - (C 1 -C 8 )alkyl, R 32 (O=)C-(C 1 - C8 ) -alkyl and R 38 is (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, aryl, aryl-(C 1 -C 8 )alkyl , heteroaryl, heteroaryl-(C 1 -C 8 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )-alkyl, (C 3 -C 10 )-cycloalkyl, (C 3 -C 10 )-cycloalkyl-( C 1 -C 8 )alkyl, R 32 (O=)C-(C 1 -C 8 )alkyl, R 32 O(O)C-(C 1 -C 8 )alkyl, R 30 R 31 N (O)C-(C 1 -C 8 )alkyl, R 33 S(O) m -(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 N-(C 1 -C 8 )-alkyl. The compounds of general formula (I) can be synthesized by addition of a suitable inorganic or organic acid, such as mineral acids such as HCl, HBr, H 2 SO 4 , H 3 PO 4 or HNO 3 , or organic acids, eg. B. carboxylic acids such as formic acid, acetic acid, propionic acid, oxalic acid, lactic acid or salicylic acid or sulfonic acids such as p-toluenesulfonic acid to a basic group such as amino, alkylamino, dialkylamino, piperidino, morpholino or pyridino. These salts then contain the conjugate base of the acid as an anion. Suitable substituents which are in deprotonated form, such as, for example, sulfonic acids, certain sulfonic acid amides or carboxylic acids, can form inner salts with groups which in turn can be protonated, such as amino groups. Salt formation can also take place by the action of a base on compounds of the general formula (I). Suitable bases are, for example, organic amines such as trialkylamines, morpholine, piperidine and pyridine and ammonium, alkali or alkaline earth metal hydroxides, carbonates and bicarbonates, in particular sodium and potassium hydroxide, sodium and potassium carbonate and sodium and potassium bicarbonate. These salts are compounds in which the acidic hydrogen is replaced by an agriculturally suitable cation, for example metal salts, in particular alkali metal salts or alkaline earth metal salts, in particular sodium and potassium salts, or else ammonium salts, salts with organic amines or quaternary ammonium salts, for example with cations of the formula [NR a R b R c R d ] + , in which R a to R d each independently represent an organic radical, in particular alkyl, aryl, aralkyl or alkylaryl. Also suitable are alkylsulfonium and alkylsulfoxonium salts, such as (C 1 -C 4 )-trialkylsulfonium and (C 1 -C 4 )-trialkylsulfoxonium salts. The compounds of the formula (I) used according to the invention and their salts are referred to below as "compounds of the general formula (I)". A preferred subject of the invention is the use of compounds of the general formula (I) in which R 1 is hydrogen, NR 30 R 31 , OR 32 , S(O)mR 33 , (C 1 -C 7 )-alkyl, (C 2 -C 7 )alkenyl, (C 2 -C 7 )alkynyl, (C 1 -C 7 )haloalkyl, (C 2 -C 7 )haloalkenyl, (C 2 -C 7 )haloalkynyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )halocycloalkyl, (C 4 -C 7 )cycloalkenyl, (C 4 -C 7 )halocycloalkenyl, aryl, aryl(C 1 -C 7 )alkyl, heteroaryl , heteroaryl(C 1 -C 7 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 7 )alkyl, R 32 O-(C 1 -C 7 )alkyl, R 30 R 31 N-(C 1 -C 7 )alkyl, R 32 O(O)C-(C 1 -C 7 )alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )alkyl, (C 3 -C 10 )-cycloalkyl(C 1 -C 7 )alkyl, R 33 S(O) m -(C 1 -C 7 )alkyl, R 32 (O=)C-(C 1 -C 7 )alkyl , C(=O)R 32 , C(=O)OR 32 m is 0, 1, 2, R 3 and R 4 are independently hydrogen, (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, (C 1 -C 10 )haloalkyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkyl-(C 1 -C 7 )alkyl, aryl-(C 1 -C 7 )alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 7 )alkyl, heterocyclyl, Heterocyclyl-(C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-alkyl, R 30 R 31 N-(C 1 -C 7 )-alkyl, R 5 , R 6 independently of one another for hydrogen, (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, (C 1 -C 7 )haloalkyl, (C 3 -C 7 )cycloalkyl, aryl-(C 1 -C 7 ) 7 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 7 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-alkyl, R 30 R 31 N-(C 1 -C 7 )alkyl, NR 30 R 31 , OR 32 , (C 3 -C 7 )cycloalkyl-(C 1 -C 7 )alkyl, R 3 and R 5 with the carbon atoms to which they are attached, a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 5 to 10-membered monocyclic or bicyclic form a ring, R 2 represents hydrogen and one of the following groups G-1 to G-2, where an arrow represents a bond to the pyrrolidinone ring in the general formula (I), R 7 represents hydrogen and one of the following groups G- 1 to G-15, wherein an arrow represents a bond to the pyrrolidinone ring in the general formula (I), with the proviso that R 2 and R 7 are not H at the same time and that R 7 represents H when R 2 represents one of the following groups G-1 to G-2, and that R 2 is H if R 7 is one of the following groups G-1 to G-15,
'
Figure imgf000013_0001
R8, R9, R10, R15, R18, R19, R20 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl-(C1-C7)-Alkyl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, S(O)mR33, R32(O=)C-(C1-C7)-Alkyl, C(O=)R32, (C1-C7)-Alkyloxycarbonyl, Aryl-(C1-C7)-Alkyloxycarbonyl stehen, R8 und R9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11, R12, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)- Alkinyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)-Alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C7)-Alkyl, R30R31N(O)C-(C1-C7)-Alkyl, OR32 stehen, R16, R17, R21, R22 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)- Alkinyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)-Alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stehen, R23, R24 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl- (C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)-Alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, C(O=)R32, (C1-C7)-Alkyloxycarbonyl, Aryl-(C1-C7)-Alkyloxycarbonyl stehen, R25, R28, R29, unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl-(C1-C7)-Alkyl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, R32(O=)C-(C1-C7)-Alkyl stehen, R26, R27 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C7)- Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)- Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)- Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkylthio-(C1-C7)-alkyl, (C1-C7)-Haloalkylthio-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)- alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)- Cycloalkenyl-(C1-C7)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C7)-Alkoxycarbonyl, Bis-[(C1- C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1- C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl, Heteroaryl-(C1-C7)- alkoxycarbonyl, (C2-C7)-Alkenyloxycarbonyl, (C2-C7)-Alkinyloxycarbonyl, Heterocyclyl- (C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkenyloxycarbonyl- (C1-C7)-alkyl, (C2-C7)-Alkinyloxycarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl- (C1-C7)-alkyl, Heteroaryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)- alkoxycarbonyl-(C1-C7)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)- Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)-Alkoxy-(C1-C7)- alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)- Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, Aryl, Aryl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxy-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)- alkyl, (C1-C7)-Alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)- alkyl, Bis-[(C1-C7)-alkyl]amino-(C2-C6)-alkyl, (C1-C7)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C7)- alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C7)-alkyl, Hydroxycarbonyl-(C1-C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)- Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, (C1-C7)- Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkylcarbonyloxy-(C1-C7)-alkyl, Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)-alkyl, Heterocyclylcarbonyloxy-(C1-C7)-alkyl, Aryloxy-(C1-C7)-alkyl, Heteroaryloxy-(C1-C7)-alkyl, Heterocyclyloxy-(C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl, (C1-C7)-Alkoxycarbonyl-(C1-C7)- alkyl, (C2-C7)-Alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkinyloxycarbonyl-(C1-C7)- alkyl, Aryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heteroaryl-(C1-C7)-alkoxycarbonyl- (C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl steht, R33 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)- alkyl, Heterocyclyl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C10)-Cycloalkenyl- (C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]amino, (C1-C7)-Alkyl-amino, Aryl-(C1-C7)-amino, Aryl-(C1- C6)-alkyl-amino, Aryl-[(C1-C7)-alkyl]amino; Heteroaryl-(C1-C7)-amino, Heteroaryl-(C1-C6)- alkyl-amino, Heteroaryl-[(C1-C7)-alkyl]amino; Hetercyclyl-(C1-C7)-amino, Heterocyclyl-(C1- C6)-alkyl-amino, Heterocyclyl-[(C1-C7)-alkyl]amino; (C3-C7)-Cycloalkyl-amino, (C3-C7)- Cycloalkyl-[(C1-C7)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R34 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)-Alkyl, NR30R31, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, S(O)mR33 steht, R35 für Wasserstoff, NR30R31, OR32, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl, Aryl- (C1-C7)-Alkyl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, S(O)mR33, R32(O=)C-(C1-C7)-Alkyl, R32O(O)C-(C1-C7)-Alkyl, R30R31N(O)C-(C1-C7)-Alkyl, R33S(O)m- (C1-C7)-alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)-Alkyl steht, R36 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl, Aryl-(C1-C7)-Alkyl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, (C3-C10)- Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, R32(O=)C-(C1-C7)-Alkyl, R32O(O)C-(C1-C7)- Alkyl, R30R31N(O)C-(C1-C7)-Alkyl, R33S(O)m-(C1-C7)-alkyl, R32O-(C1-C7)-Alkyl, R30R31N- (C1-C7)-Alkyl steht, R37 für (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C2-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, Aryl, Aryl-(C1-C7)-Alkyl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, Heteroaryloxy-(C1-C7)-Alkyl, Aryloxy-(C1-C7)- Alkyl, Heterocyclyloxy-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)-Alkyl, R32O(O)C- (C1-C7)-Alkyl, R30R31N(O)C-(C1-C7)-Alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, R33S(O)m- (C1-C7)-alkyl, R32(O=)C-(C1-C7)-Alkyl steht und R38 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)- Alkyl steht. Besonders bevorzugter Erfindungsgegenstand ist die Verwendung von Verbindungen der allgemeinen Formel (I), worin R1 für Wasserstoff, NR30R31, OR32, S(O)mR33, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)- Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C10)- Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32 steht, m für 0, 1, 2 steht, R3 und R4 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C1-C10)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, NR30R31, OR32, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl stehen, R3 und R5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R2 und R7 nicht gleichzeitig H sind und dass R7 für H steht, wenn R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R2 für H steht, wenn R7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht, '
Figure imgf000013_0001
R 8 , R 9 , R 10 , R 15 , R 18 , R 19 , R 20 are independently hydrogen, (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, (C 2 -C 7 )-alkynyl, aryl(C 1 -C 7 )alkyl, heteroaryl(C 1 -C 7 )alkyl, heterocyclyl(C 1 -C 7 )alkyl, R 32 O-(C 1 -C 7 )alkyl, (C 3 -C 7 )cycloalkyl-(C 1 -C 7 )alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 7 )alkyl , C(O=)R 32 , (C 1 -C 7 )alkyloxycarbonyl, aryl-(C 1 -C 7 )alkyloxycarbonyl, R 8 and R 9 with the nitrogen atoms to which they are attached a fully saturated one or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 5 to 10-membered monocyclic or bicyclic ring, R 11 , R 12 , R 13 , R 14 are independently hydrogen, (C 1 -C 7 ) alkyl, (C2 -C 7 )alkenyl, (C2-C 7 )alkynyl, (C 1 -C 7 )haloalkyl, (C 3 -C 7 )cycloalkyl, aryl-(C 1 -C 7 )alkyl, aryl, Heteroaryl, heteroaryl(C 1 -C 7 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 7 )alkyl, R 32 O-(C 1 -C 7 )alkyl, R 30 R 31 N-(C 1 -C 7 )alkyl, (C3-C 7 )cycloalkyl-(C 1 -C 7 )alkyl, C(=O)R 32 , C(=O) OR32 , C(=O ) NR30 R31 , R32 O(O)C-( C1 -C7 )alkyl, R30 R31 N(O)C-( C1 - C 7 )-alkyl, OR 32 , R 16 , R 17 , R 21 , R 22 are independently hydrogen, (C 1 -C 7 )-alkyl, (C2-C 7 )-alkenyl, (C2-C 7 )- alkynyl, (C 1 -C 7 )haloalkyl, (C 3 -C 7 )cycloalkyl, aryl(C 1 -C 7 )alkyl, aryl, heteroaryl, heteroaryl(C 1 -C 7 )alkyl , heterocyclyl, heterocyclyl-(C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-alkyl, R 30 R 31 N-(C 1 -C 7 )alkyl, (C 3 -C 7 )cycloalkyl-(C 1 -C 7 )alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 23 , R 24 are independently hydrogen, (C 1 -C 8 )alkyl, (C 1 -C 7 )haloalkyl, (C 3 -C 7 ) -cycloalkyl, aryl(C 1 -C 7 )alkyl, aryl, heteroaryl, heteroaryl(C 1 -C 7 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 7 )alkyl, R 32 O-( C 1 -C 7 )alkyl, R 30 R 31 N-(C 1 -C 7 )alkyl, (C 3 -C 7 )cycloalkyl-(C 1 -C 7 )alkyl, C(O=) R 32 , (C 1 -C 7 )-alkyloxycarbonyl, aryl-(C 1 -C 7 )-alkyloxycarbonyl, R 25 , R 28 , R 29 , independently of one another, represent hydrogen, (C 1 -C 7 )-alkyl, (C 2 -C 7 )alkenyl, (C 2 -C 7 )alkynyl, aryl-(C 1 -C 7 )alkyl, heteroaryl-(C 1 -C 7 )alkyl, heterocyclyl-(C 1 - C 7 )alkyl, R 32 O-(C 1 -C 7 )alkyl, (C 3 -C 7 )cycloalkyl-(C 1 -C 7 )alkyl, R 32 (O=)C-(C C 1 -C 7 )-alkyl, R 26 , R 27 independently of one another are hydrogen, (C 1 -C 7 )-alkyl, (C 1 -C 7 )-haloalkyl, (C 3 -C 7 )-cycloalkyl, ( C 3 -C 7 )cycloalkyl-(C 1 -C 7 )-alkyl, aryl-(C 1 -C 7 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 7 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 7 )-alkyl, R 30 and R 31 are independently hydrogen, (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, (C 2 -C 7 )alkynyl, (C 1 -C 7 )cyanoalkyl, (C 1 -C 7 )haloalkyl, (C 2 -C 7 )haloalkenyl, (C 3 -C 7 )haloalkynyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )halocycloalkyl, (C 4 -C 7 )cycloalkenyl, (C 4 -C 7 )halocycloalkenyl, (C 1 -C 7 )alkoxy-(C 1 -C 7 )alkyl, (C 1 -C 7 )haloalkoxy (C 1 -C 7 )alkyl, (C 1 -C 7 )alkylthio-(C 1 -C 7 )alkyl, (C 1 -C 7 )haloalkylthio-(C 1 -C 7 )alkyl, (C 1 -C 7 )alkoxy(C 1 -C 7 )haloalkyl, aryl, aryl(C 1 -C 7 )alkyl, heteroaryl, heteroaryl(C 1 -C 7 )alkyl, (C 3 -C 7 )cycloalkyl(C 1 -C 7 )alkyl, (C 4 -C 7 )cycloalkenyl(C 1 -C 7 )alkyl, COR 32 , SO2R 33 , heterocyclyl, (C 1 - C 7 )alkoxycarbonyl, bis[(C 1 -C 7 )alkyl]aminocarbonyl-(C 1 -C 7 )alkyl, (C 1 -C 7 )alkylaminocarbonyl-(C 1 -C 7 )- alkyl, Ar yl-(C 1 -C 7 )alkylaminocarbonyl-(C 1 -C 7 )alkyl, aryl-(C 1 -C 7 ) alkoxycarbonyl , heteroaryl-(C 1 -C 7 )alkoxycarbonyl, (C 2 -C 7 )alkenyloxycarbonyl, (C 2 -C 7 )alkynyloxycarbonyl, heterocyclyl-(C 1 -C 7 )alkyl, (C 1 -C 7 )alkoxycarbonyl-(C 1 -C 7 )alkyl, ( C 2 -C 7 alkenyloxycarbonyl(C 1 -C 7 )alkyl, (C 2 -C 7 )alkynyloxycarbonyl(C 1 -C 7 )alkyl, aryl(C 1 -C 7 )alkoxycarbonyl -(C 1 -C 7 )alkyl, heteroaryl-(C 1 -C 7 )alkoxycarbonyl-(C 1 -C 7 )alkyl, heterocyclyl-(C 1 -C 7 )alkoxycarbonyl-(C 1 -C 7 )-alkyl, or R 30 and R 31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R 32 is hydrogen, (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, (C 2 -C 7 )alkynyl, (C 1 -C 7 )cyanoalkyl, (C 1 -C 7 )haloalkyl, (C 2 -C 7 )haloalkenyl, (C 3 -C 7 )haloalkynyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )halocycloalkyl, (C 4 -C 7 )cycloalkenyl, (C 4 -C 7 )halocycloalkenyl, (C 1 -C 7 )alkoxy-(C 1 -C 7 )alkyl, (C 1 -C 7 )haloalkoxy-(C 1 -C 7 ) C 7 )alkyl, (C 1 -C 7 )alkoxy(C 1 -C 7 )haloalkyl, (C 1 -C 7 )alkoxy(C 1 -C 7 )alkoxy(C 1 -C 7 ). C 7 )alkyl, (C 1 -C 7 )alkoxy-(C 1 -C 7 )alkoxy-(C 1 -C 7 )alkoxy-(C 1 -C 7 )alkyl, (C 1 -C 7 )- alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, aryl, aryl-( C 1 -C 7 )alkyl, aryl(C 1 -C 7 )alkoxy(C 1 -C 7 )alkyl, heteroaryl, heteroaryl(C 1 -C 7 )alkyl, (C 3 -C 7 )cycloalkyl(C 1 -C 7 )alkyl, (C 4 -C 7 )cycloalkenyl(C 1 -C 7 )alkyl, bis[(C 1 -C 7 )alkyl]aminocarbonyl (C 1 -C 7 )alkyl, (C 1 -C 7 )alkylaminocarbonyl-(C 1 -C 7 )alkyl, aryl-(C 1 -C 7 ) alkylaminocarbonyl- (C 1 - C7 ) - alkyl, bis[(C 1 -C 7 )alkyl]amino-(C 2 -C 6 )alkyl, (C 1 -C 7 )alkylamino-(C 2 -C 6 )alkyl, Aryl-(C 1 -C 7 )alkylamino-(C 2 -C 6 )alkyl, R 33 (O)mS-(C 1 -C 7 )alkyl, Hydroxycarbonyl-(C 1 -C 7 ) -alkyl, heterocyclyl, heterocyclyl(C 1 -C 7 )alkyl, tris[(C 1 -C 7 )alkyl]silyl(C 1 -C 7 )alkyl, bis[(C 1 -C 7 )alkyl 7 )-alkyl](aryl)silyl(C 1 -C 7 )alkyl, [(C 1 -C 7 )alkyl]bis(aryl)silyl(C 1 -C 7 )alkyl, (C C 1 -C 7 )-alkylcarbonyloxy-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-cycloalkylcarbonyloxy-(C 1 -C 7 )-alkyl, arylcarbonyloxy-(C 1 -C 7 )-alkyl, heteroarylcarbonyloxy(C 1 -C 7 )alkyl, heterocyclylcarbonyloxy(C 1 -C 7 )alkyl, aryloxy(C 1 -C 7 )alkyl, heteroaryloxy(C 1 -C 7 )alkyl, heterocyclyloxy- (C 1 -C 7 )alkyl, (C 1 -C 7 )alkoxycarbonyl, (C 1 -C 7 )alkoxycarbonyl-(C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyloxycarbonyl (C 1 -C 7 )alkyl, (C 2 -C 7 )alkynyloxycarbonyl-(C 1 -C 7 )alkyl, aryl-(C 1 -C 7 )alkoxycarbonyl-(C 1 -C 7 )- alkyl, heteroaryl-(C 1 -C 7 )-alkoxycarbonyl- (C 1 -C 7 )alkyl, heterocyclyl-(C 1 -C 7 )alkoxycarbonyl-(C 1 -C 7 )alkyl, R 33 represents hydrogen, (C 1 -C 7 )alkyl, (C C 2 -C 7 )alkenyl, (C 2 -C 7 )alkynyl, (C 1 -C 7 )cyanoalkyl, (C 1 -C 10 )haloalkyl, (C 2 -C 7 )haloalkenyl, (C C 3 -C 7 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 7 )cycloalkenyl, (C 4 -C 7 )halocycloalkenyl, (C C 1 -C 7 )alkoxy(C 1 -C 7 )alkyl, (C 1 -C 7 )alkoxy(C 1 -C 7 )haloalkyl, aryl, aryl(C 1 -C 7 )- alkyl, heteroaryl, heteroaryl(C 1 -C 7 )alkyl, heterocyclyl(C 1 -C 7 )alkyl, (C 3 -C 7 )cycloalkyl(C 1 -C 7 )alkyl, (C C 4 -C 10 )cycloalkenyl(C 1 -C 7 )alkyl, bis[(C 1 -C 7 )alkyl]amino, (C 1 -C 7 )alkylamino, aryl(C 1 -C 7 amino, aryl(C 1 -C 6 )alkylamino, aryl[(C 1 -C 7 )alkyl]amino; heteroaryl(C 1 -C 7 )amino, heteroaryl(C 1 -C 6 )alkylamino, heteroaryl[(C 1 -C 7 )alkyl]amino; heterocyclyl(C 1 -C 7 )amino, heterocyclyl(C 1 -C 6 )alkylamino, heterocyclyl[(C 1 -C 7 )alkyl]amino; (C 3 -C 7 )cycloalkylamino, (C 3 -C 7 )cycloalkyl[(C 1 -C 7 )alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R 34 is hydrogen, (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, aryl-(C 1 -C 7 )alkyl, aryl, heteroaryl, heteroaryl-(C C 1 -C 7 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-alkyl, R 30 R 31 N-(C 1 -C 7 )- alkyl, NR 30 R 31 , (C 3 -C 7 )cycloalkyl-(C 1 -C 7 )alkyl, S(O) m R 33 , R 35 is hydrogen, NR 30 R 31 , OR 32 , (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, (C 2 -C 7 )alkynyl, aryl, aryl-(C 1 -C 7 )alkyl, heteroaryl, heteroaryl-(C 1 -C 7 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 7 )alkyl, R 32 O-(C 1 -C 7 )alkyl, ( C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkyl-(C 1 -C 7 )alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 7 )-alkyl, R 32 O(O)C-(C 1 -C 7 )-alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-alkyl, R 33 S(O) m - (C 1 -C 7 )-alkyl, R 32 is O-(C 1 -C 7 )-alkyl, R 30 R 31 is N-(C 1 -C 7 )-alkyl, R 36 is hydrogen, (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, (C 2 -C 7 )alkynyl, aryl, aryl-(C 1 -C 7 )alkyl, heteroaryl, heteroaryl-(C 1 -C 7 ) 7 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 7 )-alkyl, (C 3 -C 10 )-cycloalkyl, (C 3 -C 7 )-cycloalkyl-(C 1 -C 7 )-alkyl, R 32 (O=)C-(C 1 -C 7 )alkyl, R 32 O(O)C-(C 1 -C 7 )alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-alkyl, R 33 S(O)m-(C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-alkyl, R 30 R 31 N-(C 1 -C 7 ) -alkyl, R 37 is (C 1 -C 7 )- alkyl, (C 2 -C 7 )alkenyl, (C 2 -C 7 )alkynyl, (C 1 -C 7 )haloalkyl, (C 2 -C 7 )haloalkenyl, (C 2 -C 7 )- Haloalkynyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )halocycloalkyl, (C 4 -C 7 )cycloalkenyl, (C 4 -C 7 )halocycloalkenyl, aryl, aryl-(C 1 - C 7 )alkyl, heteroaryl, heteroaryl(C 1 -C 7 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 7 )alkyl, heteroaryloxy(C 1 -C 7 )alkyl, aryloxy(C C 1 -C 7 )-alkyl, heterocyclyloxy-(C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-alkyl, R 30 R 31 N-(C 1 -C 7 )-alkyl, R 32 O(O)C-(C 1 -C 7 )alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )alkyl, (C 3 -C 7 )cycloalkyl-(C C 1 -C 7 )alkyl, R 33 is S(O)m-(C 1 -C 7 )alkyl, R 32 is (O=)C-(C 1 -C 7 )alkyl and R 38 is (C C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, aryl, aryl-(C 1 -C 8 )alkyl, heteroaryl, heteroaryl-(C 1 - C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )cycloalkyl(C 1 -C 8 )alkyl, R 32 (O=)C-(C 1 -C 8 )alkyl, R 32 O(O)C-(C 1 -C 8 )alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )alkyl, R 33 S(O)m-(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 is N-(C 1 -C 8 )-alkyl. A particularly preferred subject of the invention is the use of compounds of the general formula (I) in which R 1 is hydrogen, NR 30 R 31 , OR 32 , S(O) m R 33 , (C 1 -C 6 )-alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloalkenyl, (C 2 -C 6 )haloalkynyl, (C 3 -C 6 cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 )halocycloalkenyl, aryl, aryl-(C 1 -C 6 )alkyl , heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-alkyl, R 30 R 31 N-( C 1 -C 6 )alkyl, R 32 O(O)C-(C 1 -C 6 )alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )alkyl, (C 3 -C10 )- Cycloalkyl-(C 1 -C 6 )alkyl, R 33 S(O) m -(C 1 -C 6 )alkyl, R 32 (O=)C-(C 1 -C 6 )alkyl, C( =O)R 32 , C(=O)OR 32 m is 0, 1, 2, R 3 and R 4 are independently hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )-alkenyl, (C 1 -C 10 )haloalkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )-alkyl, aryl-(C 1 - C 6 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-alkyl, R 30 R 31 are N-(C 1 -C 6 )-alkyl, R 5 , R 6 independently of one another are hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 1 -C 6 )haloalkyl, (C 3 -C 6 )cycloalkyl, aryl-(C 1 -C 6 )alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl-( C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl, R 30 R 31 N-(C 1 -C 6 )alkyl, NR 30 R 31 , OR 32 , (C 3 -C 6 ) -cycloalkyl (C 1 -C 6 ) alkyl, R 3 and R 5 with the carbon atoms to which they are attached, a fully saturated or partially saturated gten, optionally interrupted by heteroatoms and optionally further substituted 5 to 10-membered monocyclic or bicyclic ring, R 2 represents hydrogen and one of the following groups G-1 to G-2, where an arrow represents a bond to the pyrrolidinone ring in general formula (I), R 7 represents hydrogen and one of the following groups G-1 to G-15, where an arrow represents a bond to the pyrrolidinone ring in general formula (I), with the proviso that R 2 and R 7 are not H at the same time and that R 7 is H when R 2 is one of the following groups G-1 to G-2, and that R 2 is H when R 7 is one of the following groups G-1 to G-15 stands,
'
Figure imgf000018_0001
R8, R9, R10, R15, R18, R19, R20 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)-Alkyloxycarbonyl stehen, R8 und R9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11, R12, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, OR32 stehen, R16, R17, R21, R22 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stehen, R23, R24 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl- (C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)-Alkyloxycarbonyl stehen, R25, R28, R29 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl stehen, R26, R27 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)- Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)- Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C6)-Alkoxycarbonyl, Bis-[(C1- C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1- C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl, Heteroaryl-(C1-C6)- alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)-Alkinyloxycarbonyl, Heterocyclyl- (C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkenyloxycarbonyl- (C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)- alkoxycarbonyl-(C1-C6)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)- Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)- alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)- alkyl, Bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C6)- alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, Hydroxycarbonyl-(C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)- Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1-C6)- Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)-alkyl, Heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)- alkyl, (C2-C6)-Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)- alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl steht, R33 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)- alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C10)-Cycloalkenyl- (C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1- C6)-alkyl-amino, Aryl-[(C1-C6)-alkyl]amino; Heteroaryl-(C1-C6)-amino, Heteroaryl-(C1-C6)- alkyl-amino, Heteroaryl-[(C1-C6)-alkyl]amino; Hetercyclyl-(C1-C6)-amino, Heterocyclyl-(C1- C6)-alkyl-amino, Heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)- Cycloalkyl-[(C1-C6)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R34 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, NR30R31, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33 steht, R35 für Wasserstoff, NR30R31, OR32, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl- (C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, R33S(O)m- (C1-C6)-alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl steht, R36 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, (C3-C10)- Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)- Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32O-(C1-C6)-Alkyl, R30R31N- (C1-C6)-Alkyl steht, R37 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, Heteroaryloxy-(C1-C6)-Alkyl, Aryloxy-(C1-C6)- Alkyl, Heterocyclyloxy-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C- (C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m- (C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl steht und R38 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)- Alkyl steht. Ganz besonders bevorzugter Erfindungsgegenstand ist die Verwendung von Verbindungen der allgemeinen Formel (I), worin R1 für Wasserstoff, NR30R31, OR32, S(O)mR33, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)- Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C10)- Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32 steht, m für 0, 1, 2 steht, R3 und R4 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Vinyl, 1-Methyleth-1-en-1.yl, prop-2-en-1-yl, Difluormethyl, Trifluormethyl, Cyclopropyl, Cyclobutyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Phenyl, Benzyl, Methoxymethyl, Ethoxymethyl, Methoxyethyl, Ethoxyethyl stehen, R5, R6 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Vinyl, prop-2-en-1-yl, Difluormethyl, Trifluormethyl, Cyclopropyl, Cyclobutyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Phenyl, 4-Fluorphenyl, 3- Fluorphenyl, 2-Fluorphenyl, 4-Chlorphenyl, 3-Chlorphenyl, 2-Chlorphenyl, Benzyl, 4- Fluorbenzyl, 3-Fluorbenzyl, 2-Fluorbenzyl, Pyridin-2-ylmethyl, Pyridin-3-ylmethyl, Pyridin-4- ylmethyl, Methoxymethyl, Ethoxymethyl, Methoxyethyl, Ethoxyethyl, Heterocyclyl, Hydroxy, Methoxy, Ethoxy, Methylcarbonyloxy, Ethylcarbonyloxy, 1-Methyleth-1-ylcarbonyloxy, 1,1- Dimethyleth-1-ylcarbonyloxy stehen, R3 und R5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R2 und R7 nicht gleichzeitig H sind und dass R7 für H steht, wenn R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R2 für H steht, wenn R7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht, '
Figure imgf000023_0001
R8, R9, R10, R15, R18, R19, R20 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)-Alkyloxycarbonyl stehen, R8 und R9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11, R12, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, OR32 stehen, R16, R17, R21, R22 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stehen, R23, R24 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl- (C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)-Alkyloxycarbonyl stehen, R25, R28, R29 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl stehen, R26, R27 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)- Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)- Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C6)-Alkoxycarbonyl, Bis-[(C1- C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1- C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl, Heteroaryl-(C1-C6)- alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)-Alkinyloxycarbonyl, Heterocyclyl- (C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkenyloxycarbonyl- (C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)- alkoxycarbonyl-(C1-C6)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)- Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)- alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)- alkyl, Bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C6)- alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, Hydroxycarbonyl-(C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)- Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1-C6)- Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)-alkyl, Heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)- alkyl, (C2-C6)-Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)- alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl steht, R33 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)- alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C10)-Cycloalkenyl- (C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1- C6)-alkyl-amino, Aryl-[(C1-C6)-alkyl]amino; Heteroaryl-(C1-C6)-amino, Heteroaryl-(C1-C6)- alkyl-amino, Heteroaryl-[(C1-C6)-alkyl]amino; Hetercyclyl-(C1-C6)-amino, Heterocyclyl-(C1- C6)-alkyl-amino, Heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)- Cycloalkyl-[(C1-C6)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R34 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, NR30R31, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33 steht, R35 für Wasserstoff, NR30R31, OR32, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl- (C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, R33S(O)m- (C1-C6)-alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl steht, R36 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, (C3-C10)- Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)- Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32O-(C1-C6)-Alkyl, R30R31N- (C1-C6)-Alkyl steht, R37 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, Heteroaryloxy-(C1-C6)-Alkyl, Aryloxy-(C1-C6)- Alkyl, Heterocyclyloxy-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C- (C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m- (C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl steht und R38 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)- Alkyl steht. Im Speziellen bevorzugter Erfindungsgegenstand ist die Verwendung der folgenden von der allgemeinen Formel (I) beschriebenen Verbindungen: 2-[1-[(3-Chlor-2-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(1-methyl-1H-tetrazol-5-yl)acetamid, (2S,3S)-2-[[2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-methylpentancarbonsäure, Methyl 5-[[2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-oxopentanoat, 2-(4- fluorphenoxy)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, Methyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-methylsulfonylethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-methylsulfanylethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2S,3S)-2-[[2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]-3-methylpentancarbonsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, 1-[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]pyrrolidine-2-carbonsäure, 2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]essigsäure, 2-methoxyethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2R,3R)-2- [[2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3- methylpentancarbonsäure, Cyclopentyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2,2-Dimethylpropyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, Ethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, cyclopropylmethyl 2-[1-[(2,3-difluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetat, allyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(3- Chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-Phenylsulfanylethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, Prop-2-yn-1-yl 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, Cyclobutyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, Isopropyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, But-3-en-1-yl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-Phenoxyethyl 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, Pentan-2-yl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2- (4-Chlorphenyl)sulfinylethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, Butan-2-yl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(4-Methoxyphenoxy)ethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(3,4-Difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]essigsäure, 2-(Benzylsulfonyl)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2- (4-chlorphenoxy)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(4- methylphenoxy)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(2,3-difluor-4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 3-methylbutan-2-yl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, methyl (2S)-2-[[2-[(2R)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(1H-imidazol-4-yl)propionat, 2-[(4- chlorphenyl)thio]ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[(2S)-1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-phenylsulfanylethyl 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(4-chlorphenyl)sulfinylethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[(2R)-1-[(3,4-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]essigsäure, 2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, (2R)-2- [[2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, 2- [(4-methoxyphenyl)thio]ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[(4- methylphenyl)thio]ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, methyl 2-[1-[(3- chlor-2-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2R,3R)-2-[[2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-methylpentancarbonsäure, 2-(4- fluorphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2R)-2-[[2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, 4-[2-[2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]oxyethoxy]benzoesäure, (2R)-2-[[2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentancarbonsäure, 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-methylsulfonylacetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(4-methyl-1,2,5-oxadiazol-3-yl)acetamid, 2-(4- chlorphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(4- methylphenyl)sulfinylethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(2,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-phenylsulfanylethyl 2-[1-[(3- fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, methyl 2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrolidin- 2-yl]acetat, 2-[1-[(3,5-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, methyl 1-[[2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]cyclopropanecarboxylat, 2-(2,4- dichlorphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(4- fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, ethyl 2-(1-benzyl-5-oxopyrrolidin-2-yl)acetat, 2- [1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-hydroxyethyl)acetamid, methyl 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2S)-2-[[2-[(2R)-1-[(4-ethylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentancarbonsäure, methyl (2S)-2-[[2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(1H-imidazol-4-yl)propionate, 2-[1-[(2- fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-(1-benzyl-5-oxopyrrolidin-2-yl)essigsäure, 2-[1- [(3-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, (2S)-2-[[2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(trifluormethylsulfonyl)acetamid, 2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrolidin- 2-yl]-N-methyl-N-methylsulfonylacetamid, methyl 2-[[2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]-methylamino]acetat, 2-(4-methoxyphenyl)sulfonylethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]essigsäure, methyl 5-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4- oxopentanoat, methyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N-benzyl-2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, (2S)-4-methyl-2-[[2-[1-[(3- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentancarbonsäure, N-[2-(3- methylphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-methylpropyl)acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N',N'-dimethylacetohydrazid, N-(2-hydroxyethyl)-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-(4-formylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, N-allyl-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N- [(1-ethyl-3-methyl-1H-pyrazol-4-yl)methyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, 2-(4-methoxyphenyl)sulfinylethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, (2R,3R)-2-[[2-[(2S)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3- methylpentancarbonsäure, N-methyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- methylsulfonylacetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2- phenylethyl)acetamid, 2-(2,4-dimethylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, N-[(6-chlorpyridin-3-yl)methyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- methylacetamid, (2R)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4- methylsulfanylbuttersäure, methyl 3-[[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]butyrat, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2- methylpropyl)acetamid, methyl 3-[[2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]propionat, 2-[1-[(3-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (trifluormethylsulfonyl)acetamid, methyl 3-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]butyrate, [(1S,2R,5R)-2-isopropyl-5-methylcyclohexyl] 2-[(2R)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]essigsäure, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-prop-2-yn-1- ylacetamid, 2-(4-bromophenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamid, [(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl] 2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, 2-[5-oxo-3-phenyl-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]essigsäure, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-propylacetamid, (2S)-2-[[2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(1H-indol-3-yl)propionsäure, (2R)-2-[[2- [1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(1H-indol-3-yl)propionsäure, 2-[1- [(3-chlor-2-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[5-oxo-1-[(3,4,5- trifluorphenyl)methyl]pyrrolidin-2-yl]essigsäure, 2-(4-ethylphenoxy)ethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-phenoxyethyl 2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, 1-[(2,3-difluorphenyl)methyl]-5-(2-oxo-2-pyrrolidin-1-ylethyl)pyrrolidin-2- on, 2-(4-methylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-ethylsulfonylacetamid, (2S)-2-[[2-[(2S)-1-[(4- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentancarbonsäure, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N,N-diethylacetamid, 2-[1-[(3-chlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(difluormethylsulfonyl)acetamid, Ethyl-(2R)-1-[2-[(2S)-1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, 2-[3- (trifluormethyl)phenoxy]ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(4-tert- butylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N- (difluormethylsulfonyl)-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2- methoxyethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[(4-chlorphenyl)thio]ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamid, 2-[1-[(4-chlorphenyl)methyl]-5- oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- isopropylsulfonylacetamid, 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, (2R,3R)- 2-[[2-[(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-methylpentancarbonsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(pyridin-2-ylmethyl)acetamid, 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(chinolin-5-ylmethyl)acetamid, 2,2-dimethylpropyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(2-chlorphenoxy)ethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-methylsulfanylethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[[3-fluor-5-(trifluormethyl)phenyl]methyl]-5- oxopyrrolidin-2-yl]essigsäure, ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(2- chlorphenyl)sulfonylethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, methyl 2-[[2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]benzoate, 2-(2,4- dichlorphenyl)sulfonylethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N-[2-(3,4- dichlorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, prop-2-yn-1-yl 2- [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(2,2,2-trifluorethylsulfonyl)acetamid, N-benzyl-2-[1-[(4-methylphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (dimethylsulfamoyl)acetamid, methyl 3-[[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]propionate, 2-phenylsulfanylethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, 2-[1-[1-(4-fluorphenyl)cyclopropyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1-ethyl-1H-pyrazol-3-yl)methyl]acetamid, but-3-en-1- yl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, methyl (2S)-3-(1H-imidazol-4-yl)-2-[[2- [(2S)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-,yl]acetyl]amino]propionate, 2-[1-[(3- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, N-(difluormethylsulfonyl)-2-[1-[(3- fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, methyl 4-[2-[2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]oxyethoxy]benzoat, N-cyclopropylsulfonyl-2-[1-[(2,3-difluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluor-4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- methylsulfonylacetamid, 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (trifluormethylsulfonyl)acetamid, 2-[1-[(3,4-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (dimethylsulfamoyl)acetamid, 2-[1-[[3,5-bis(trifluormethyl)phenyl]methyl]-5-oxopyrrolidin-2- yl]essigsäure, 2-[1-[(3-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, N- cyclopropyl-2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(4-ethylphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, (2S)-2-[[2-[(2S)-1-[(2-ethylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentancarbonsäure, cyclopropylmethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(4-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]- N-methylsulfonylacetamid, tert-butyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2- [1-[[3-(difluormethoxy)phenyl]methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(3-fluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[4-(acetylamino)phenoxy]ethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N-[2-(4-tert-butylphenyl)ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(2,2,2-trifluorethyl)acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin- 2-yl]-N-(2-methoxyethyl)acetamid, 2-[1-[2-(4-fluorphenyl)propan-2-yl]-5-oxopyrrolidin-2- yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-prop-2-yn-1-ylacetamid, 2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(2-ethylphenyl)methyl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1-ethyl-3-methyl-1H-pyrazol-4-yl)methyl]acetamid, N-[(6-chlorpyridin-3-yl)methyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1- [(2,3-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(difluormethylsulfonyl)acetamid, isopropyl 2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, cyclobutyl 2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, 2-[1-[[4-(difluormethoxy)phenyl]methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2- [1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(3-methylbutyl)acetamid, N-[2-(2- bromophenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-ethylacetamid, (2R)-4-methyl-2-[[2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentancarbonsäure, 2-[5-oxo-1-[[3- (trifluormethyl)phenyl]methyl]-pyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[2-(3,5-dimethoxyphenyl)ethyl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamid, N-isopropyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, Natrium;[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]- methylsulfonylazanid, N-[(6-chlorpyridin-3-yl)methyl]-2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, methyl 3-[[2-[1-[(3,4-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]propionate, N-[2-(2,4-difluorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, cyclopentyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2- [5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methylacetamid, allyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(trifluormethylsulfonyl)acetamid, 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, methyl 2-[methyl- [2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]acetat, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1R,2S)-2,6-dimethylindan-1-yl]acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[5-oxo-1-[[3- (trifluormethoxy)phenyl]methyl]pyrrolidin-2-yl]essigsäure, N-(difluormethylsulfonyl)-2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, butan-2-yl 2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, N-butan-2-yl-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, 2-[1-[(2-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, (2S)-3-(1H-indol-3-yl)-2-[[2- [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionsäure, (2R)-2-[[2-[1-[(3- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, 2-[1-[(4- chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(trifluormethylsulfonyl)acetamid, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(furan-2-ylmethyl)acetamid, (2S)-2-[[2-[(2R)-1-[(2- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentancarbonsäure, 2-[5-oxo-1-[[3- (pentafluor-λ6-sulfanyl)phenyl]methyl]pyrrolidin-2-yl]essigsäure, 2-[1-[(3-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamid, 1-[(4-tert-butylphenyl)methyl]-5-[2- oxo-2-(2-thiophen-2-ylazepan-1-yl)ethyl]pyrrolidin-2-on, 2-[1-[(4-tert-butylphenyl)methyl]-5- oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(1H-indol- 3-yl)ethyl]acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, pentan-2-yl 2- [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 1-[(4-methylphenyl)methyl]-5-(2-oxo-2- pyrrolidin-1-ylethyl)pyrrolidin-2-on, 2-[5-oxo-1-[[6-(trifluormethyl)pyridin-3-yl]methyl]pyrrolidin-2- yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-propylacetamid, N- (difluormethylsulfonyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,2- difluor-1,3-benzodioxol-5-yl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(3-chlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamid, N-[(2-fluorphenyl)methyl]-2-[5-oxo-1-[(4- phenylphenyl)methyl]pyrrolidin-2-yl]acetamid, N-butan-2-yl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[1-[(4-methoxyphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, N-[2-(2- fluorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(2,6- difluorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(2-fluorphenyl)methyl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(3-methylphenyl)ethyl]acetamid, (2R)-4-methyl-2- [[2-[(2R)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentancarbonsäure, N- (dimethylsulfamoyl)-2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-benzhydryl-2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-methyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-phenylacetamid, 1-[(2,4-dichlorphenyl)methyl]-5-[2-(4-methylpiperazin-1-yl)-2- oxoethyl]pyrrolidin-2-on, [(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl] 2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2- yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-[3-(trifluormethoxy)phenyl]- ethyl]acetamid, 2-[5-oxo-1-[[4-(pentafluor-λ6-sulfanyl)phenyl]methyl]pyrrolidin-2-yl]essigsäure, 4-[[2- (carboxymethyl)-5-oxopyrrolidin-1-yl]methyl]benzoesäure, N-[2-(3,4-dichlorphenyl)ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-cyclopropyl-2-[1-[(3,4-difluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetamid, 2-[1-[[3-fluor-2-(trifluormethyl)phenyl]methyl]-5-oxopyrrolidin-2- yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-indan-1-ylacetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(chinolin-6-ylmethyl)acetamid, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(furan-2-ylmethyl)acetamid, (2R)-4-methyl-2-[[2-[(2S)-1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentancarbonsäure, 2-[5-oxo-1-(pyridin-4- ylmethyl)pyrrolidin-2-yl]essigsäure, 2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2,2,2-trifluorethyl)acetamid, tert-butyl (2S)-2- [[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(4-hydroxyphenyl)propionat, N-[2-(4-tert-butylphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[5- oxo-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]essigsäure, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin- 2-yl]acetamid, methyl (2S)-2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4- methylpentanoat, [(Z)-[3-(dimethylamino)propylamino]-(ethylimino)methyl] 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N-[(2-ethylphenyl)methyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[1-[(4-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (dimethylsulfamoyl)acetamid, N-cyclopropyl-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, (2S)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3- phenylpropionsäure, 2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3- phenylpropionsäure, 3-methylbutan-2-yl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, methyl 3-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionat, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(difluormethylsulfonyl)acetamid, (2R)-2-[[2-[(2S)-1- [(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, 2-[[2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylsulfanylbuttersäure, (2R)-2-[[2- [(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-ethylacetamid, 2-[1-[1-(4-fluorphenyl)ethyl]-5- oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,6-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1- [1-(3-fluorphenyl)ethyl]-5-oxopyrrolidin-2-yl]essigsäure, 1-[2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]pyrrolidine-2-carboxylic acid, 2-[1-[(4-cyanophenyl)methyl]-5-oxopyrrolidin- 2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-isopropylacetamid, ethyl 1- [2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidin-2-carboxylat, 2-[1-[(2- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, (2S)-2-[[(2S)-2-[[2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentanoyl]amino]-4- methylpentancarbonsäure, 2-[5-oxo-1-[[4-(trifluormethylthio)phenyl]methyl]pyrrolidin-2-yl]essigsäure, 2-[1-[(4-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(difluormethylsulfonyl)acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(trifluormethylsulfonyl)acetamid, 2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamid, (2R)-2-[[2- [(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentancarbonsäure, (2S)- 2-[[2-[(2S)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, 2- [1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(2-fluorphenyl)ethyl]acetamid, 1-[(2,4- dichlorphenyl)methyl]-5-[2-oxo-2-(2-propylpyrrolidin-1-yl)ethyl]pyrrolidin-2-on, methyl 2-[[2-[(2S)-1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylamino]acetat, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methylsulfonylacetamid, N-[2-(2,6- difluorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-cyclopropyl-2- [1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, ethyl 1-[2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, methyl 2-[[2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]benzoat, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- phenylacetamid, N-[(6-chlorpyridin-3-yl)methyl]-N-methyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-benzhydryl-2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, N-cyclopropyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[1-(3,4- difluorphenyl)ethyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxopyrrolidin- 2-yl]-N-(dimethylsulfamoyl)acetamid, (2S)-1-[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]pyrrolidin-2-carbonsäure, 2-[1-[(3,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[(2-fluorphenyl)methyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-(1-benzyl- 5-oxopyrrolidin-2-yl)-N-(2-phenylethyl)acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2- yl]-N,N-dimethylacetamid, N-(dimethylsulfamoyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, methyl (2R)-2-[[2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3- phenylpropionat, methyl (2R)-2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-3-phenylpropionat, N',N'-dimethyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetohydrazid, N-benzhydryl-2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, ethyl 1- [2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, 4-methyl-2-[[2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentancarbonsäure, 2-[(2R)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamid, N-cyclopropyl-2-[(2S)-1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-ethyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-methyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-(isochinolin-5-ylmethyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N- (cyclohexylmethyl)-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, (2S)-2-[[(2R)-2- [[2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropanoyl]amino]-3- phenylpropionsäure, N-[2-(4-fluorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, N-benzhydryl-2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[(2S)-1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamid, 2-[1-[(2- fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methylsulfonylacetamid, 1-[(2- chlorphenyl)methyl]-5-[2-[2-(3,4-dichlorphenyl)azepan-1-yl]-2-oxoethyl]pyrrolidin-2-on, methyl 2-[[2- [(2R)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylamino]acetat, 2-[1-[(4- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamid, N-(2-methoxyethyl)-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, ethyl 1-[2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, (2S)-4-methyl-2-[[2-[1-[(2-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]pentancarbonsäure, N-allyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2- methoxyethyl)acetamid, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(4- fluorphenyl)methyl]acetamid, N-cyclohexyl-2-[5-oxo-1-[[3-(trifluormethyl)phenyl]methyl]-pyrrolidin- 2-yl]acetamid, N-[2-(2-bromphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-[3- (trifluormethoxy)phenyl]ethyl]acetamid, N-benzhydryl-2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, 2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5- yl)acetamid, (2R)-3-(1H-indol-3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]propionsäure, (2S)-2-[[2-[(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-3-phenylpropionsäure, N-benzhydryl-2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-[2-(1H-indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[5-oxo-1-[[4-(trifluormethyl)phenyl]methyl]pyrrolidin-2-yl]essigsäure, methyl 2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylamino]acetat, N-[3- (diethylamino)propyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, (2S)-2-[[2-[(2S)-1-[(2- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(chinolin-6-ylmethyl)acetamid, N-[(2,4- difluorphenyl)methyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamid, methyl 4- [[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]butyrat, tert-butyl (2S)-3-(4- hydroxyphenyl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionat, N- [(2-fluorphenyl)methyl]-2-[5-oxo-1-[[3-(trifluormethyl)phenyl]methyl]pyrrolidin-2-yl]acetamid, [(1S,2R,5R)-2-isopropyl-5-methylcyclohexyl] 2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, ethyl 1-[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, 2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylamino]essigsäure, N-methyl-2-[1- [(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-phenylacetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-phenylacetamid, methyl 2-[methyl-[2-[1-[(3-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]acetat, (2R)-2-[[2-[(2S)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-4-methylpentancarbonsäure, N-cyclopropyl-2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-cyclopropyl-2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, (2R,3R)-2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3- methylpentancarbonsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-[3- (trifluormethyl)phenyl]-ethyl]acetamid, N-[2-(diethylamino)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-[(2,4-difluorphenyl)methyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-benzhydryl-2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, (2R,3R)-2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3- methylpentancarbonsäure, N-[(1-ethyl-1H-pyrazol-3-yl)methyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-[2-(diethylamino)ethyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, (2S,3S)-3-methyl-2-[[2-[(2S)-1-[(3-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]-amino]pentancarbonsäure, N-cyclopropyl-2-[1-[(2-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-[2-(3,5-dimethoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[5-oxo-3-phenyl-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]essigsäure, ethyl 1-[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, methyl 2-[[2-[1- [(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylamino]acetat, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(isochinolin-5-ylmethyl)acetamid, 2-[1-[(6-chlorpyridin- 3-yl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamid, N-cyclopropyl-2-[1-[(4- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-benzhydryl-2-[1-[(4-isopropylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, ethyl 1-[2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]piperidine-2-carboxylat, 2-[5-oxo-1-[[5-(trifluormethyl)pyridin-2-yl]methyl]pyrrolidin-2- yl]essigsäure, 2-[[2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]- methylamino]essigsäure, ethyl 2-(1-benzyl-5-oxopyrrolidin-2-yl)propionat, N-(cyclohexylmethyl)-2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, ethyl 1-[2-[1-[(6-chlorpyridin-3-yl)methyl]-5- oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, N-benzhydryl-2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-(3-methylbutyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, N-cyclopropyl-2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[1-[(5-methoxypyridin-2- yl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[5-oxo-1-[[2-(trifluormethyl)phenyl]methyl]pyrrolidin-2- yl]essigsäure, 2-[1-[[3-fluor-4-(trifluormethyl)phenyl]methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[[5- fluor-2-(trifluormethyl)phenyl]methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[5-oxo-1-[[4-(2,2,2- trifluorethoxy)phenyl]methyl]pyrrolidin-2-yl]essigsäure, N-methylsulfonyl-2-[5-oxo-3-phenyl-1- (pyridin-2-ylmethyl)pyrrolidin-2-yl]acetamid, N-[3-(diethylamino)propyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(3,4-difluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2- yl]propionsäure, 2-[1-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-(1-benzyl-5-oxopyrrolidin-2-yl)propionsäure, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]- N-(chinolin-5-ylmethyl)acetamid, 2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]-N- cyclopropylacetamid, N-methylsulfonyl-2-[5-oxo-3-phenyl-1-(pyridin-3-ylmethyl)pyrrolidin-2- yl]acetamid, methyl (2R)-2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3- phenylpropionat, 2-[1-[(3-fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N- methylsulfonylacetamid, 2-[[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]- methylamino]essigsäure, N-methyl-2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- phenylacetamid, 2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, methyl 2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylamino]acetat, 2-[1-[(2- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamid, 2-[1-[(4- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2- yl]essigsäure, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]propionsäure, 2-[1-[(4- fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[1-[(2,6- difluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[1-[(3,4- difluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]essigsäure, methyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]propionate, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[2-(4-fluorphenyl)ethyl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(5- methoxy-1H-indol-3-yl)ethyl]acetamid, 2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]-N- methylsulfonylacetamid, 2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H- 1,2,4-triazol-5-yl)acetamid, (2S,3S)-2-[[2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-3-methylpentancarbonsäure, 2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2- yl]essigsäure, N-benzhydryl-2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamid, ethyl 1-[2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, 2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamid, methyl 2- [[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylamino]acetat, methyl 2-[methyl-[2- [1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]acetat, 2-[[2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylamino]essigsäure, 2-[1-[(2- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamid, 2-[1-[(4-ethylphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamid, ethyl 1-[2-[1-[(3- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, 5-[2-[4-(4- chlorphenyl)piperazin-1-yl]-2-oxoethyl]-1-[(2,4-dichlorphenyl)methyl]pyrrolidin-2-on, N-cyclohexyl-2- [1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 1-[(2,4-dichlorphenyl)methyl]-5-(2-oxo- 2-piperidin-1-ylethyl)pyrrolidin-2-on, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2- pyrrolidin-1-ylethyl)acetamid, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-2- ylethyl)acetamid, 1-[(4-tert-butylphenyl)methyl]-5-[2-[2-(4-methoxyphenyl)azepan-1-yl]-2- oxoethyl]pyrrolidin-2-on, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2- ethylbutyl)acetamid, 5-[2-[2-(3,4-dichlorphenyl)azepan-1-yl]-2-oxoethyl]-1-[[3- (trifluormethyl)phenyl]methyl]pyrrolidin-2-on, 1-[(2,4-difluorphenyl)methyl]-5-[2-(2- isopropylpyrrolidin-1-yl)-2-oxoethyl]pyrrolidin-2-on, 5-[2-[2-(3,4-dichlorphenyl)azepan-1-yl]-2- oxoethyl]-1-[(4-phenylphenyl)methyl]-pyrrolidin-2-on, N,N-dibenzyl-2-[5-oxo-1-(pyridin-2- ylmethyl)pyrrolidin-2-yl]acetamid, Benzyl-N-[2-[[2-[5-oxo-1-[[3- (trifluormethyl)phenyl]methyl]pyrrolidin-2-yl]acetyl]amino]-ethyl]carbamat, 1-[(4-tert- butylphenyl)methyl]-5-[2-oxo-2-(4-pyridin-2-ylpiperazin-1-yl)ethyl]pyrrolidin-2-on, N-(2- bicyclo[2.2.1]heptanyl)-2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]acetamid, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1R)-1-cyclohexylethyl]acetamid, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-ethyl-N-propylacetamid, 1-[(2-chlorphenyl)methyl]-5- [2-[2-(2-methylpropyl)pyrrolidin-1-yl]-2-oxoethyl]pyrrolidin-2-on, 1-[(4-tert-butylphenyl)methyl]-5-[2- (2,6-dimethylmorpholin-4-yl)-2-oxoethyl]pyrrolidin-2-on, 1-benzyl-5-[2-[2-(3,4- dichlorphenyl)pyrrolidin-1-yl]-2-oxoethyl]pyrrolidin-2-on, 2-[5-oxo-1-[(4- phenylphenyl)methyl]pyrrolidin-2-yl]-N-pentylacetamid, N-(2-bicyclo[2.2.1]heptanyl)-2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 5-[2-(1,2,3,4,4a,5,6,7,8,8a-decahydroisochinolin- 2-yl)-2-oxoethyl]-1-[(4-methylphenyl)methyl]pyrrolidin-2-on, 5-[2-(2-ethylpiperidin-1-yl)-2-oxoethyl]- 1-[(4-phenylphenyl)methyl]pyrrolidin-2-on, 5-[2-oxo-2-(2-propylpyrrolidin-1-yl)ethyl]-1-[(4- phenylphenyl)methyl]pyrrolidin-2-on, N-(cyclohexylmethyl)-2-[1-[(2,4-dichlorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2,3- dimethylcyclohexyl)acetamid, 1-benzyl-5-(2-isoindolin-2-yl-2-oxoethyl)pyrrolidin-2-on, N,N-dibenzyl- 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 1-[(2,4-difluorphenyl)methyl]-5-[2-[2- (3-methoxyphenyl)azepan-1-yl]-2-oxoethyl]pyrrolidin-2-on, N-(2,3-dimethylcyclohexyl)-2-[5-oxo-1- [(4-phenylphenyl)methyl]-pyrrolidin-2-yl]acetamid, 5-[2-[2-(3,4-dichlorphenyl)pyrrolidin-1-yl]-2- oxoethyl]-1-[[3-(trifluormethyl)phenyl]methyl]pyrrolidin-2-on, 2-[1-[(4-tert-butylphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(2-ethylhexyl)acetamid, N-(2-bicyclo[2.2.1]heptanyl)-2-[1-[(2,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 5-[2-[2-(3,4-dichlorphenyl)azepan-1-yl]-2- oxoethyl]-1-[(2,4-difluorphenyl)methyl]pyrrolidin-2-on, N-[(1R)-1-cyclohexylethyl]-2-[5-oxo-1-[(1R)- 1-phenylethyl]pyrrolidin-2-yl]acetamid, N-benzyl-2-(1-benzyl-5-oxopyrrolidin-2-yl)-N-methylacetamid, 2-(1-benzyl-5-oxopyrrolidin-2-yl)-N-(pyridin-2-ylmethyl)acetamid, N,N-diethyl-1-[2-[5-oxo-1-[[3- (trifluormethyl)phenyl]methyl]pyrrolidin-2-yl]acetyl]piperidine-3-carboxamid, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(2-methylphenyl)methyl]acetamid, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-morpholin-4-ylethyl)acetamid, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(2-fluorphenyl)methyl]acetamid, 1-[(2,4- difluorphenyl)methyl]-5-[2-(3,5-dimethylpiperidin-1-yl)-2-oxoethyl]pyrrolidin-2-on, 1-[(2,4- dichlorphenyl)methyl]-5-(2-morpholin-4-yl-2-oxoethyl)pyrrolidin-2-on, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-pentan-3-ylacetamid, 2-[1-[(2,4-dichlorphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-(3,3-dimethylbutyl)acetamid, 1-[(4-tert-butylphenyl)methyl]-5-(2-oxo-2- thiomorpholin-4-ylethyl)pyrrolidin-2-on, N-ethyl-2-[5-oxo-1-[[3-(trifluormethyl)- phenyl]methyl]pyrrolidin-2-yl]acetamid, 1-benzyl-5-(2-oxo-2-thiomorpholin-4-ylethyl)pyrrolidin-2-on, 5-[2-[4-(4-chlorphenyl)piperazin-1-yl]-2-oxoethyl]-1-[(1R)-1-phenylethyl]pyrrolidin-2-on, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(5-methylhexan-2-yl)acetamid, 2-[1-[(2- chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-cyclohexylacetamid, 2-[1-[(2-chlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N,N-dimethylacetamid, N-benzyl-2-[1-[(2,4-dichlorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- cyclopentylacetamid, N-[(4-fluorphenyl)methyl]-2-[5-oxo-1-[[3- (trifluormethyl)phenyl]methyl]pyrrolidin-2-yl]acetamid, 1-[(2,4-dichlorphenyl)methyl]-5-[2-oxo-2-[4- (pyridin-2-ylmethyl)piperazin-1-yl]ethyl]pyrrolidin-2-on, 2-[1-[(2,4-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(3,3,5-trimethylcyclohexyl)acetamid, 2-[1-[(2-chlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[3-(dimethylamino)propyl]acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(2-phenylethyl)acetamid, N-benzyl-2-[1-[(2,4-dichlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methylacetamid, 1-[(4-tert-butylphenyl)methyl]-5-(2-oxo-2-pyrrolidin-1- ylethyl)pyrrolidin-2-on, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(oxolan-2- ylmethyl)acetamid, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(2- chlorphenyl)methyl]acetamid, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyrrolidin-1- ylethyl)acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[3-(1H-imidazol-1- yl)propyl]acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2- (dimethylamino)ethyl]-N-methylacetamid, 1-[(4-tert-butylphenyl)methyl]-5-(2-oxo-2-piperidin-1- ylethyl)pyrrolidin-2-on, (2S)-2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4- methylpentancarbonsäure, (2R,3R)-2-[[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-3-methylpentancarbonsäure, methyl (2S)-3-(1H-imidazol-4-yl)-2-[[2-[(2R)-1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionat, (2S)-2-[[2-[(2R)-1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, 2-[[2-[(2R)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylamino]essigsäure, N-(2- bicyclo[2.2.1]heptanyl)-2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]acetamid, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1S)-1-cyclohexylethyl]acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-phenylethyl)acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-3-ylethyl)acetamid, N-[2-(2- methoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-2-ylethyl)acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-[3-(trifluormethyl)phenyl]ethyl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-[4-(trifluormethoxy)phenyl]ethyl]acetamid, N-[2-(3- bromphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(2,5- dichlorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3- difluor-phenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-thiophen-2-ylethyl)acetamid, 2-[5-oxo-1-(pyridin-3- ylmethyl)pyrrolidin-2-yl]propionsäure, Methyl 2-[5-oxo-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]acetat, Methyl 2-[5-oxo-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]propionat, 2-[1-[(4-fluorphenyl)methyl]-5- oxopyrrolidin-2-yl]propionsäure, N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(2- methoxyphenyl)ethyl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(3,4- imethoxyphenyl)ethyl]-acetamid, 2-[1-[(4-fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2- yl]essigsäure, 2-[1-[(2-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionsäure, 2-(1-benzyl-5-oxo-3- phenylpyrrolidin-2-yl)-N-methylsulfonylacetamid, 2-[1-[(2,4-difluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]-N-methylsulfonylacetamid, methyl 4-[[2-[1-[(2,3-difluorphenyl)-methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]butyrat, N-[2-(4-chlorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-3- ylethyl)acetamid, N-[2-(2,5-dichlorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, 2-[1-[(3-fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]essigsäure, methyl 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionat, methyl 2-[1-[(3-fluorphenyl)methyl]-5- oxopyrrolidin-2-yl]propionat, 2-[1-[(2,4-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionsäure, 2-[1- [(3,4-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionsäure, 2-[1-[(3-fluorphenyl)methyl]-5- oxopyrrolidin-2-yl]propionsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionsäure, 2-[1-[(2,6-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionsäure, 2-(1-benzyl-5-oxo-3- phenylpyrrolidin-2-yl)essigsäure, N-[2-[3-chlor-5-(trifluormethyl)pyridin-2-yl]ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-[3-chlor-5-(trifluormethyl)pyridin-2- yl]ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[1-(3,5- difluorphenyl)ethyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]-N-methylsulfonylacetamid, methyl 2-[1-[(2,4-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, methyl 2-[1-[(2,6-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionat, N- [2-(2,4-difluorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(3- bromphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(4-methoxyphenyl)ethyl]acetamid, methyl 2-[5-oxo- 1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]propionat, 4-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]butyric acid, methyl 2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]acetat, 2-[1-[(2- fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[2-(3-methoxyphenyl)ethyl]acetamid, N-[2-(2,3-dichlorphenyl)ethyl]-2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin- 2-yl]-N-[2-[4-(trifluormethoxy)-phenyl]ethyl]acetamid, methyl 2-[1-[(2-fluorphenyl)methyl]-5- oxopyrrolidin-2-yl]propionat, N-[2-[3,5-bis(trifluormethyl)phenyl]ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-[3,5-bis(trifluormethyl)phenyl]ethyl]-2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[2-(4-methylphenyl)ethyl]acetamid, methyl 2-[1-[(4-fluorphenyl)methyl]-5- oxopyrrolidin-2-yl]propionat, methyl 2-[1-[(2,4-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionat, methyl 2-[1-[(2,6-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(2,4-difluorphenyl)methyl]- 5-oxo-3-phenylpyrrolidin-2-yl]essigsäure, 2-[1-[(4-methylphenyl)-methyl]-5-oxo-3-phenylpyrrolidin-2- yl]essigsäure, N-[2-(3-methoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, N-[2-(3-chlorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, N-[2-(3-chlorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(4-methoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(2- chlorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(4- methylphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(2- chlorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)-methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-2-ylethyl)acetamid, N-[2-(2,4- dichlorphenyl)-ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(4- chlorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(3-fluorphenyl)ethyl]acetamid, N-[2-(2,4- dichlorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(3- fluorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-thiophen-2-ylethyl)acetamid, (2R)-2-[[2-[1-[(4- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, 2-(1-benzyl-5- oxopyrrolidin-2-yl)-N-(oxolan-2-ylmethyl)acetamid, 2-(1-benzyl-5-oxopyrrolidin-2-yl)-N- cyclohexylacetamid, N-(2,2-difluorethyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, N-(2,2-difluorethyl)-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, [5- Oxo-1-(2,3,6-trifluorbenzyl)pyrrolidin-2-yl]essigsäure, [5-Oxo-1-(2,3,4-trifluorbenzyl)pyrrolidin-2- yl]essigsäure, [5-Oxo-1-(2,3,5-trifluorbenzyl)pyrrolidin-2-yl]essigsäure, [5-Oxo-1-(2,3- dimethylbenzyl)pyrrolidin-2-yl]essigsäure, N-[(4-chlorphenyl)methyl]-1-(2-methylpropyl)-5- oxopyrrolidine-3-carboxamid, 1-benzyl-5-oxo-N-[[3-(trifluormethyl)phenyl]methyl]pyrrolidine-3- carboxamid, N-[(2,3-dichlorphenyl)methyl]-5-oxo-1-phenylpyrrolidine-3-carboxamid, 1-[2-(4- chlorphenyl)ethyl]-N-[(3,5-dimethoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, N-[(3,5- dichlorphenyl)methyl]-5-oxo-1-prop-2-yn-1-ylpyrrolidine-3-carboxamid, 1-[(4-chlorphenyl)methyl]-5- oxo-N-(pyridin-3-ylmethyl)pyrrolidin-3-carboxamid, 1-benzyl-N-[(5-methylpyrazin-2-yl)methyl]-5- oxopyrrolidine-3-carboxamid, 1-(1,3-benzodioxol-5-ylmethyl)-N-[(2,3-dichlorphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, 1-benzyl-N-methyl-5-oxo-N-(pyridin-4-ylmethyl)pyrrolidine-3- carboxamid, 1-[(4-chlorphenyl)methyl]-N-[(2-methoxyphenyl)methyl]-N-methyl-5-oxopyrrolidine-3- carboxamid, 1-(4-methylphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamid, N-[(4- methoxyphenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidin-3-carboxamid, 1-benzyl-N-[(2,3- dichlorphenyl)methyl]-5-oxopyrrolidin-3-carboxamid, N-benzyl-1-(2-methylpropyl)-5-oxopyrrolidine- 3-carboxamid, 1-benzyl-N-[(2,5-dichlorphenyl)methyl]-5-oxopyrrolidin-3-carboxamid, N-[(2- chlorphenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidin-3-carboxamid, N-[(2,4-dichlorphenyl)methyl]- 1-(2-methylpropyl)-5-oxopyrrolidin-3-carboxamid, N-[(3-chlor-4-fluorphenyl)methyl]-1-ethyl-5- oxopyrrolidin-3-carboxamid, 1-(3,5-dimethylphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3- carboxamid, 1-[2-(4-fluorphenyl)ethyl]-5-oxo-N-(pyridin-3-ylmethyl)pyrrolidine-3-carboxamid, N- [(2,5-dichlorphenyl)methyl]-5-oxo-1-phenylpyrrolidine-3-carboxamid, N-[(3,4-dichlorphenyl)methyl]- 1-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamid, 1-cyclopropyl-N-[(4-methylphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, 1-butan-2-yl-N-[(4-methylphenyl)methyl]-5-oxopyrrolidine-3- carboxamid, 1-ethyl-N-[(4-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, 5-oxo-N-[indan-1- yl]-1-[3-(trifluormethyl)phenyl]pyrrolidine-3-carboxamid, N-[(2,3-difluorphenyl)methyl]-1-ethyl-5- oxopyrrolidine-3-carboxamid, 1-butan-2-yl-N-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidine-3- carboxamid, 1-cyclopropyl-N-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, N-[(2,3- difluorphenyl)methyl]-1-isopropyl-5-oxopyrrolidine-3-carboxamid, 1-[3,5-bis(trifluormethyl)phenyl]-5- oxo-N-[[2-(trifluormethoxy)pyridin-4-yl]methyl]pyrrolidine-3-carboxamid, N-[(2-chlorpyridin-4- yl)methyl]-6-(3,5-dichlorphenyl)-2,4-dimethyl-7-oxo-6-azabicyclo[3.2.1]oct-3-ene-8-carboxamid, 1- [3,5-bis(trifluormethyl)phenyl]-N-[[2-(ethylamino)pyrimidin-4-yl]methyl]-5-oxopyrrolidine-3- carboxamid, 1-(4-fluorphenyl)-5-oxo-N-[indan-1-yl]pyrrolidine-3-carboxamid, 1-(2,4-difluorphenyl)-N- [indan-1-yl]-5-oxopyrrolidine-3-carboxamid, N-[(6-chlorpyridin-3-yl)methyl]-1-(4-methoxyphenyl)-5- oxopyrrolidine-3-carboxamid, N-[(2-chlorphenyl)methyl]-1-(2-methoxyphenyl)-5-oxopyrrolidine-3- carboxamid, 1-[3-(difluormethoxy)phenyl]-5-oxo-N-[indan-1-yl]pyrrolidine-3-carboxamid, (3RS)-1- (2,4-difluorphenyl)-N-[(1R*)-indan-1-yl]-5-oxopyrrolidine-3-carboxamid, 1-[3-(difluormethyl)phenyl]- 5-oxo-N-[indan-1-yl]pyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1- [3-(difluormethoxy)phenyl]-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2- yl]methyl]-5-oxo-1-[3-(trifluormethyl)phenyl]pyrrolidine-3-carboxamid, N,3-dimethyl-5-oxo-1-phenyl- N-[1,2,3,4-tetrahydronaphthalin-1-yl]pyrrolidine-3-carboxamid, 1-butan-2-yl-N-[(3-chlor-4- fluorphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, 1-benzyl-N-[(2-chlorphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, N-[(3-chlor-4-fluorphenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidine- 3-carboxamid, N-[(3-chlor-4-fluorphenyl)methyl]-1-isopropyl-5-oxopyrrolidine-3-carboxamid, N-[(4- chlorphenyl)methyl]-5-oxo-1-phenylpyrrolidine-3-carboxamid, N-benzyl-5-oxo-1-phenylpyrrolidine-3- carboxamid, N-[(4-chlorphenyl)methyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, N- benzyl-1-(4-chlorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(4-fluorphenyl)methyl]-1-(4- methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, N-benzyl-1-(4-methoxyphenyl)-5-oxopyrrolidine-3- carboxamid, 1-(4-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, N- [(5-chlor-2-methylphenyl)methyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(2,4- dichlorphenyl)methyl]-5-oxo-1-phenylpyrrolidine-3-carboxamid, N-[(2,4-dichlorphenyl)methyl]-1-(4- methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, 1-(4-methoxyphenyl)-5-oxo-N-(pyridin-2- ylmethyl)pyrrolidine-3-carboxamid, 5-oxo-1-phenyl-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamid, N-[(2,3-difluorphenyl)methyl]-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(2,3- difluorphenyl)methyl]-1-(4-fluorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(2-chlorphenyl)methyl]-1- (4-fluorphenyl)-5-oxopyrrolidine-3-carboxamid, 1-cyclopentyl-5-oxo-N-(pyridin-2- ylmethyl)pyrrolidine-3-carboxamid, 1-(4-fluorphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3- carboxamid, 1-(4-chlorphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamid, 1-(4- chlorphenyl)-N-[(2,5-dichlorphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, 1-(4-chlorphenyl)-N-[(6- chlorpyridin-3-yl)methyl]-5-oxopyrrolidine-3-carboxamid, N-[(2,5-dichlorphenyl)methyl]-1-(2,4- difluorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1-(2- methylpropyl)-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1- cyclopentyl-5-oxopyrrolidine-3-carboxamid, 1-(2,4-difluorphenyl)-N-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, 1-[3-(difluormethoxy)phenyl]-N-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, N-[(2,5-dichlorphenyl)-methyl]-5-oxo-1-[3- (trifluormethyl)phenyl]pyrrolidine-3-carboxamid, 1-[3-(difluormethyl)phenyl]-N-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, N-[(2-chlorphenyl)methyl]-1-[3- (difluormethoxy)phenyl]-5-oxopyrrolidine-3-carboxamid, N-[(2,6-dichlorphenyl)methyl]-1-[3- (difluormethoxy)phenyl]-5-oxopyrrolidine-3-carboxamid, N-[(2,6-dichlorphenyl)methyl]-1-[3- (difluormethyl)phenyl]-5-oxopyrrolidine-3-carboxamid, N-[(2-chlorphenyl)methyl]-1-(2,4- difluorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(2,6-dichlorphenyl)methyl]-1-(4-fluorphenyl)-5- oxopyrrolidine-3-carboxamid, N-[(2,5-dichlorphenyl)methyl]-1-[3-(difluormethoxy)phenyl]-5- oxopyrrolidine-3-carboxamid, N-[(2,4-dichlorphenyl)methyl]-1-(2,4-difluorphenyl)-5-oxopyrrolidine-3- carboxamid, N-[(2,5-dichlorphenyl)methyl]-1-[3-(difluormethyl)phenyl]-5-oxopyrrolidine-3- carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1-(4-fluorphenyl)-5-oxopyrrolidine-3- carboxamid, N-[(2,4-dichlorphenyl)methyl]-1-(4-fluorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(2,5- dichlorphenyl)methyl]-1-(4-fluorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(2,6- dichlorphenyl)methyl]-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(2,6- dichlorphenyl)methyl]-1-(2,4-difluorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(2- chlorphenyl)methyl]-1-[3-(difluormethyl)phenyl]-5-oxopyrrolidine-3-carboxamid, 1-(4-chlorphenyl)-N- [[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5- (trifluormethyl)pyridin-2-yl]methyl]-1-cyclobutyl-5-oxopyrrolidine-3-carboxamid, 5-oxo-N-(pyridin-2- ylmethyl)-1-[3-(trifluormethyl)phenyl]pyrrolidine-3-carboxamid, N-[(2,3-difluorphenyl)methyl]-5-oxo- 1-[3-(trifluormethyl)phenyl]pyrrolidine-3-carboxamid, N-[(2,5-dichlorphenyl)methyl]-1-(2- methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1- (2,4-difluorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]- 1-[3-(difluormethyl)phenyl]-5-oxopyrrolidine-3-carboxamid, N-[(6-chlorpyridin-3-yl)methyl]-1-(4- methylphenyl)-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-5- oxo-1-phenylpyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1-(2- methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(6-chlorpyridin-3-yl)methyl]-1-cyclopentyl-5- oxopyrrolidine-3-carboxamid, N-[(2,4-dichlorphenyl)methyl]-1-[3-(difluormethoxy)phenyl]-5- oxopyrrolidine-3-carboxamid, N-[(2-chlorphenyl)methyl]-1-cyclopentyl-5-oxopyrrolidine-3- carboxamid, 1-(2,4-difluorphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamid, 1- cyclobutyl-5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidine-3-carboxamid, 1-[3-(difluormethyl)phenyl]-5- oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamid, 1-[3-(difluormethoxy)phenyl]-5-oxo-N-(pyridin- 2-ylmethyl)pyrrolidine-3-carboxamid, 1-cyclopentyl-5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidine-3- carboxamid, 1-(2-methylpropyl)-5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidine-3-carboxamid, N-[(6- chlorpyridin-3-yl)methyl]-1-cyclobutyl-5-oxopyrrolidine-3-carboxamid, 1-(2-methylpropyl)-5-oxo-N- (pyridin-2-ylmethyl)pyrrolidine-3-carboxamid, N-[(6-chlorpyridin-3-yl)methyl]-1-(2-methylpropyl)-5- oxopyrrolidine-3-carboxamid, N-[(6-chlorpyridin-3-yl)methyl]-5-oxo-1-phenylpyrrolidine-3- carboxamid, 1-cyclobutyl-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamid, N-[(2- cyclobutyloxypyridin-4-yl)methyl]-1-(3,5-difluorphenyl)-3-methyl-5-oxopyrrolidine-3-carboxamid, 1- (3,5-difluorphenyl)-3-methyl-5-oxo-N-[[2-(2,2,2-trifluorethoxy)pyridin-4-yl]methyl]pyrrolidine-3- carboxamid, 1-(3,5-difluorphenyl)-3-methyl-N-[(2-methylsulfanylpyrimidin-4-yl)methyl]-5- oxopyrrolidine-3-carboxamid, N-[(2-chlorpyrimidin-4-yl)methyl]-1-(3,5-dichlorphenyl)-3-methyl-5- oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-N-[[2-(ethylamino)pyrimidin-4-yl]methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-3-methyl-5-oxo-N-[(2-propoxypyridin-4- yl)methyl]pyrrolidin-3-carboxamid, 1-(3,5-dichlorphenyl)-N-[[2-(difluormethoxy)-pyridin-4-yl]methyl]- 3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-N-[(2-ethoxypyrimidin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, N-benzyl-6-(3,5-dichlorphenyl)-N,2,4-trimethyl-7-oxo-6- azabicyclo[3.2.1]oct-3-ene-8-carboxamid, 1-(3,5-difluorphenyl)-N-[(2-methoxypyridin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-N-[(2-methoxypyridin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-N-[(2-ethoxypyrimidin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-N-[(2-ethoxypyridin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-N-[(2-ethoxypyridin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-3-methyl-N-[[2-(methylamino)pyrimidin- 4-yl]methyl]-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-N-[[2-(ethylamino)pyrimidin-4- yl]methyl]-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-N-[(2-isopropyloxypyridin- 4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-3-methyl-N-[[2- (methylamino)pyrimidin-4-yl]methyl]-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-N-[(2- ethylsulfanylpyrimidin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)- N-[[2-[ethyl(methyl)amino]pyridin-4-yl]methyl]-3-methyl-5-oxopyrrolidine-3-carboxamid, N-[(2- chlorpyrimidin-4-yl)methyl]-1-(3,5-difluorphenyl)-3-methyl-5-oxopyrrolidine-3-carboxamid, N-[(2- chlorpyridin-4-yl)methyl]-1-(3,5-difluorphenyl)-3-methyl-5-oxopyrrolidine-3-carboxamid, N-[(2- chlorpyridin-4-yl)methyl]-1-(3,5-dichlorphenyl)-3-methyl-5-oxopyrrolidine-3-carboxamid, N-[(2-tert- butoxypyridin-4-yl)methyl]-1-(3,5-difluorphenyl)-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5- difluorphenyl)-N-[[2-[ethyl(methyl)amino]pyridin-4-yl]methyl]-3-methyl-5-oxopyrrolidine-3- carboxamid, 1-(3,5-difluorphenyl)-3-methyl-N-[(2-morpholin-4-ylpyridin-4-yl)methyl]-5- oxopyrrolidine-3-carboxamid, N-[(2-tert-butoxypyridin-4-yl)methyl]-1-(3,5-dichlorphenyl)-3-methyl-5- oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-N-[(2-isopropyloxypyrimidin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, N-[[2-(difluormethoxy)pyridin-4-yl]methyl]-1-(3,5- difluorphenyl)-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3-chlor-5-methylphenyl)-N-[(2- chlorpyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-3-methyl-N- [(2-methylsulfanylpyrimidin-4-yl)methyl]-5-oxopyrrolidine-3-carboxamid, N-[(2-chlorpyridin-4- yl)methyl]-3-methyl-5-oxo-1-phenylpyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-3-methyl-5-oxo- N-[(2-propoxypyridin-4-yl)methyl]pyrrolidine-3-carboxamid, N-[(2-cyclobutyloxypyridin-4-yl)methyl]- 1-(3,5-dichlorphenyl)-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-N-[(2- ethylsulfanylpyrimidin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)- N-[(2-isopropyloxypyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5- dichlorphenyl)-N-[(2-isopropyloxypyrimidin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamid, 1- (3,5-difluorphenyl)-N-[[2-(4-fluorphenoxy)pyridin-4-yl]methyl]-3-methyl-5-oxopyrrolidine-3- carboxamid, 1-(3,5-dichlorphenyl)-N-[[2-(4-fluorphenoxy)pyridin-4-yl]methyl]-3-methyl-5- oxopyrrolidine-3-carboxamid, N-benzyl-N,2,4-trimethyl-7-oxo-6-(3,4,5-trichlorphenyl)-6- azabicyclo[3.2.1]oct-3-ene-8-carboxamid, N-[[2-(ethylamino)pyrimidin-4-yl]methyl]-2,4-dimethyl-7- oxo-6-(3,4,5-trichlorphenyl)-6-azabicyclo[3.2.1]oct-3-ene-8-carboxamid, 6-(3,5-dichlorphenyl)-N-[[2- (ethylamino)pyrimidin-4-yl]methyl]-2,4-dimethyl-7-oxo-6-azabicyclo[3.2.1]oct-3-ene-8-carboxamid, N- [(2-chlorpyridin-4-yl)methyl]-2,4-dimethyl-7-oxo-6-(3,4,5-trichlorphenyl)-6-azabicyclo[3.2.1]oct-3- ene-8-carboxamid, 1-(3,5-dichlorphenyl)-3-methyl-5-oxo-N-[[2-(2,2,2-trifluorethoxy)pyridin-4- yl]methyl]pyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-3-methyl-N-[(2-morpholin-4-ylpyridin-4- yl)methyl]-5-oxopyrrolidine-3-carboxamid, 1-(4-chlorphenyl)-N-[(2-chlorphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, 1-(4-chlorphenyl)-N-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidine-3- carboxamid, 1-(4-chlorphenyl)-N-[(4-chlorphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, 1-(4- chlorphenyl)-N-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, N-[(5-chlor-2- methylphenyl)methyl]-1-(4-chlorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(4-fluorphenyl)methyl]-1- (4-methylphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(4-chlorphenyl)methyl]-1-(4-methylphenyl)-5- oxopyrrolidine-3-carboxamid, N-[(4-methoxyphenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3- carboxamid, N-[(5-chlor-2-methylphenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(2,4-dichlorphenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(2,3- difluorphenyl)methyl]-1-methyl-5-oxopyrrolidine-3-carboxamid, 1-methyl-N-[(4- methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, 1-cyclopentyl-N-[(4-methylphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, N-[(3-chlor-4-fluorphenyl)methyl]-1-cyclopentyl-5-oxopyrrolidine-3- carboxamid, N-[(3-chlor-4-fluorphenyl)methyl]-1-methyl-5-oxopyrrolidine-3-carboxamid, 1- cyclopentyl-N-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, N-[(5-chlor-2- methylphenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamid, 1-cyclobutyl-N-[(4- fluorphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, N-benzyl-1-cyclobutyl-5-oxopyrrolidine-3- carboxamid, 1-cyclobutyl-N-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, N-[(4- chlorphenyl)methyl]-1-cyclobutyl-5-oxopyrrolidine-3-carboxamid, N-[(2-chlorphenyl)methyl]-1- cyclobutyl-5-oxopyrrolidine-3-carboxamid, N-[(4-fluorphenyl)methyl]-1-(2-methylpropyl)-5- oxopyrrolidine-3-carboxamid, 1-cyclobutyl-N-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidine-3- carboxamid, N-[(5-chlor-2-methylphenyl)methyl]-1-cyclobutyl-5-oxopyrrolidine-3-carboxamid, N-[1- (3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphenyl)acetamid, 2-(2,5-dichlorphenyl)-N-[1-(4- fluorphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphenyl)acetamid, 2-(2,5-dichlorphenyl)-N- [1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(4-methoxyphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]acetamid, 2-(2-chlorphenyl)-N-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]acetamid, N-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphenyl)acetamid, 2-(2,5-dichlorphenyl)-N-[1-(3,5- difluorphenyl)-4-methyl-5-oxopyrrolidin-3-yl]acetamid, 2-(2-chlorphenyl)-N-[1-(3,5-difluorphenyl)-4- methyl-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-(5-oxo-1-phenylpyrrolidin-3- yl)acetamid, 2-(2,5-dichlorphenyl)-N-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5- dichlorphenyl)-N-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)acetamid, N-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamid, N-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]-2-(2- methylphenyl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylphenyl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamid, N-(1-cyclopropyl-5- oxopyrrolidin-3-yl)-2-(2,5-dichlorphenyl)acetamid, 2-(2-chlorphenyl)-N-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]acetamid, N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorphenyl)acetamid, 2- (2-methylphenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acetamid, 2-(2-chlorphenyl)-N-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]acetamid, N-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-2-(2,5- dimethylphenyl)acetamid, 2-(2,5-dimethylphenyl)-N-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acetamid, N-[1-(4-fluorphenyl)-5- oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamid, 2-(2,5-dimethylphenyl)-N-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)acetamid, N- [1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylphenyl)acetamid, 2-(2-chlorphenyl)-N-[1-(4- methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(1-isopropyl-5- oxopyrrolidin-3-yl)acetamid, N-(1-isopropyl-5-oxopyrrolidin-3-yl)-2-(2-methylphenyl)acetamid, 2-(2,5- dichlorphenyl)-N-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2-chlorphenyl)-N-(1- cyclobutyl-5-oxopyrrolidin-3-yl)acetamid, 2-(2-chlorphenyl)-N-[2-(2-chlorphenyl)acetyl]-N-(1- cyclobutyl-5-oxopyrrolidin-3-yl)acetamid, 2-(4-chlorphenyl)-N-[2-(4-chlorphenyl)acetyl]-N-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]acetamid, 1-(4-fluorphenyl)-3-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(4-brom-3-methylphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3- yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-chlorphenyl)- 3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-(5-oxo-1-phenylpyrrolidin- 3-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4- chlorphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(4-acetylphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorphenyl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2- methylphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-fluorphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(6-chlorpyridin-3-yl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(6- chlorpyridin-3-yl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(2-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(2-chlorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(4-chlorphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1- (2-chlorphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-acetylphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin- 3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,5- dimethylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(3-chlorphenyl)-5-oxopyrrolidin-3- yl]-3-(4-fluorphenyl)harnstoff, 1-[1-(2-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorphenyl)harnstoff, 1-(4-acetylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-methylpyridin-2-yl)harnstoff, 1-(6-chlorpyridin-3-yl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)harnstoff, 1-[1-(3-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)harnstoff, 1-(4-chlorphenyl)-3-(4-methyl-5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(6-methylpyridin-2-yl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1- (4-fluorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3- (5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]-3-(6- methylpyridin-2-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5- oxo-1-phenylpyrrolidin-3-yl)-3-pyridin-2-ylharnstoff, 1-(2-chlorphenyl)-3-[1-(4-methoxyphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-difluorphenyl)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5- oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 4-[4-[3-(2-chlorphenyl)-2,4,5-trioxoimidazolidin-1-yl]- 2-oxopyrrolidin-1-yl]benzonitril, 1-(2-fluorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5-oxopyrrolidin-3- yl]harnstoff, 1-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphenyl)harnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)imidazolidine-2,4,5-trion, 1-(5-chlor-2-methylphenyl)-3-(5-oxo-1-chinolin- 8-ylpyrrolidin-3-yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2- fluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-(5-oxo-1-chinolin- 8-ylpyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,5-difluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(3,5- difluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,5-difluorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-fluorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]imidazolidine-2,4,5-trion, 1-(2-chlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]imidazolidine-2,4,5-trion, 1-(2-chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3- yl)imidazolidine-2,4,5-trion, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)imidazolidine-2,4,5-trion, 3-[4-[3-(2-chlorphenyl)-2,4,5-trioxoimidazolidin-1-yl]-2- oxopyrrolidin-1-yl]benzonitril, 1-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)imidazolidine-2,4,5-trion, 1-(5-chlor-2-methylphenyl)-3-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5- oxopyrrolidin-3-yl]harnstoff, 1-(2,3-dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(2-fluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,6- difluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]-3-(2-methylphenyl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5-oxopyrrolidin-3- yl]harnstoff, 1-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 1-(2- chlorphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-fluorphenyl)-3-[1-(2- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-fluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3- yl)harnstoff, 1-(2-chlorphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)harnstoff, 1-[1-(3-cyanophenyl)- 5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 1-(2-chlorphenyl)-3-[1-(4-cyanophenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1- (2,5-difluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(3-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(2,6-dichlorphenyl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-methylpropyl)- 5-oxopyrrolidin-3-yl]harnstoff, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2,5-difluorphenyl)harnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-fluorphenyl)harnstoff, 1-(2,5-difluorphenyl)-3-(1-isopropyl- 5-oxopyrrolidin-3-yl)harnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-methylphenyl)harnstoff, 1- (1-cyclopropyl-5-oxopyrrolidin-3-yl)-3-(2,5-difluorphenyl)harnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3- yl)-3-(2,5-difluorphenyl)harnstoff, 1-(2-fluorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(2-methylphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,5- difluorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-(1- cyclobutyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3- yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2- chlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(1-cyclopropyl-5-oxopyrrolidin-3-yl)-3- (2-fluorphenyl)harnstoff, 1-(2-fluorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(1- cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2-fluorphenyl)harnstoff, 1-[1-(3-cyanophenyl)-5-oxopyrrolidin-3- yl]-3-(2,5-difluorphenyl)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl)harnstoff, 1-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5- difluorphenyl)harnstoff, 1-(2,6-difluorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5- chlor-2-methylphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-chlorphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3- yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(5-chlor-2- methylphenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-(1- isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorpyridin-4-yl)-3-[1-(4- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-pyridazin-4- ylharnstoff, 1-(4-fluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)harnstoff, 1-[1-(4-cyanophenyl)- 5-oxopyrrolidin-3-yl]-3-[2-(trifluormethyl)phenyl]harnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3- [2-(trifluormethyl)phenyl]harnstoff, 1-(2-cyanophenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3- yl)harnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-[2-(trifluormethyl)phenyl]harnstoff, 1-(2- chlorpyridin-4-yl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)harnstoff, 1-(5-oxo-1-phenylpyrrolidin-3-yl)- 3-[2-(trifluormethyl)phenyl]harnstoff, 1-(4-fluorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3-phenylharnstoff, 1-(2-chlorpyridin-4-yl)-3-[1- (4-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(4- fluorphenyl)harnstoff, 1-(2-cyanophenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2- cyanophenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorpyridin-4-yl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(2-cyanophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(1- isopropyl-5-oxopyrrolidin-3-yl)-3-phenylharnstoff.1-(4-fluorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3- yl)harnstoff., 1-(2-cyanophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(1-isopropyl-5- oxopyrrolidin-3-yl)-3-[2-(trifluormethyl)phenyl]harnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3- pyridazin-4-ylharnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3-pyridazin-4-ylharnstoff, 1-(5-oxo-1- phenylpyrrolidin-3-yl)-3-pyridazin-4-ylharnstoff, 1-(1-isopropyl-5-oxopyrrolidin-3-yl)-3-pyridazin-4- ylharnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-phenylharnstoff, 1-(2,5-dichlorphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin- 3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1- (2,5-dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1- (3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3- cyanophenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-fluorphenyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3- yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3- yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1- [1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphenyl)thioharnstoff, 1-(5-chlor-2- methylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)thioharnstoff, 1-(2,4-dichlorphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)thioharnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(2-methylpropyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]thioharnstoff, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2,5-dichlorphenyl)thioharnstoff, 1-[1-(4- cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphenyl)thioharnstoff, 1-(5-chlor-2-methylphenyl)-3- (1-cyclopropyl-5-oxopyrrolidin-3-yl)thioharnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,4- dichlorphenyl)thioharnstoff, 1-(2-chlorphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)thioharnstoff, 1- (2,5-dichlorphenyl)-3-[1-(3,5-difluorphenyl)-4-methyl-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2- chlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2-chlorphenyl)-3-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2-chlorphenyl)-3-[1-(2-methylpropyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3- yl)thioharnstoff, 1-(2-chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(1- cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2,5-dichlorphenyl)thioharnstoff, 1-(2-chlorphenyl)-3-(1-cyclobutyl- 5-oxopyrrolidin-3-yl)thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin- 3-yl]thioharnstoff, 1-(2,4-dichlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)thioharnstoff, 1-(5-chlor- 2-methylphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)thioharnstoff Im ganz Speziellen bevorzugter Erfindungsgegenstand ist die Verwendung der folgenden von der allgemeinen Formel (I) beschriebenen Verbindungen: 4-[2-[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]oxyethoxy]benzoesäure, Methyl-(2S)- 2-[[2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(1H-imidazol-4- yl)propionat, 2-(4-Formylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2R)-2-[[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4- methylsulfanylbuttersäure, 2-[(2S)-1-[(2,3-Difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-(4- ethylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 1-[(2,3- Difluorphenyl)methyl]-5-(2-oxo-2-pyrrolidin-1-ylethyl)pyrrolidin-2-on, 2-(4-methylphenoxy)ethyl 2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(2,3-Difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(chinolin-5-ylmethyl)acetamid, N-Benzyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, Methyl 3-[[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]propionat, 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N- phenylacetamid, Butan-2-yl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2S)-3-(1H- Indol-3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionsäure, 2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(1H-indol-3-yl)ethyl]acetamid, N-Butan-2-yl-2- [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, (2R)-4-Methyl-2-[[2-[(2R)-1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentancarbonsäure, 2-[(2R)-1-[(2,3- Difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, (2S)-2-[[2-[1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, (2R)-1-[2-[1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]pyrrolidin-2-carbonsäure, 2-[1-[(4- cyanophenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, (2S)-2-[[2-[(2S)-1-[(4-Methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, Methyl 2-[[2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]benzoate, N-Cyclopropyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-(Isochinolin-5-ylmethyl)-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-[2-(2-Bromphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, (2R)-3-(1H-indol-3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]propionsäure, N-[2-(1H-indol-3-yl)ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, Methyl 2-[[2-[1-[(4-ethylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]-methylamino]acetat, 2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]- N-(quinolin-6-ylmethyl)acetamid, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[(1-ethyl-1H-pyrazol-3-yl)methyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(Diethylamino)ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, (2S,3S)-3-Methyl-2-[[2-[(2S)-1-[(3- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentancarbonsäure, 2-[[2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylamino]essigsäure, N-Methylsulfonyl-2-[5- oxo-3-phenyl-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]acetamid, 2-[1-[(4-Methylphenyl)methyl]-5- oxopyrrolidin-2-yl]propionsäure, methyl (2S)-3-(1H-imidazol-4-yl)-2-[[2-[(2R)-1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionat, 2-[1-[(2,3-Difluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-[2-(2-methoxyphenyl)ethyl]acetamid, 2-[1-[(4-fluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]essigsäure, 2-[1-[(3-Fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2- yl]essigsäure, Methyl-2-[1-[(3,4-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionate, 2-(1-Benzyl-5- oxo-3-phenylpyrrolidin-2-yl)essigsäure, N-[2-[3-Chlor-5-(trifluormethyl)pyridin-2-yl]ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-[3-Chlor-5-(Trifluormethyl)pyridin-2- yl]ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 1-Cyclopentyl-5-oxo-N- (pyridin-2-ylmethyl)pyrrolidin-3-carboxamid, 1-(4-Chlorphenyl)-N-[(6-chlorpyridin-3-yl)methyl]-5- oxopyrrolidin-3-carboxamid, 1-Cyclobutyl-5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidin-3-carboxamid, N- [(5-Chlor-2-methylphenyl)methyl]-1-(4-chlorphenyl)-5-oxopyrrolidin-3-carboxamid, N-[(2,4- Dichlorphenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrolidin-3-carboxamid, 1-Cyclopentyl-N-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-3-carboxamid, N-[1-(4-Cyanophenyl)-5-oxopyrrolidin-3-yl]-2- (2,5-dichlorphenyl)acetamid, 2-(2,5-Dichlorphenyl)-N-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]acetamid, N-(1-Cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorphenyl)acetamid, 2-(2,5- Dichlorphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)acetamid, 2-(2,5-Dimethylphenyl)-N-(1-isopropyl- 5-oxopyrrolidin-3-yl)acetamid, N-(1-Isopropyl-5-oxopyrrolidin-3-yl)-2-(2-methylphenyl)acetamid, 2-(2- Chlorphenyl)-N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)acetamid, 1-(5-Chlor-2-methylphenyl)-3-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-Chlor-2-methylphenyl)-3-[1-(3-chlorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(6-Chlorpyridin-3-yl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-Chlor-2-methylphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(4- Chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(5-Chlor-2-methylphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(5-Chlor-2-methylphenyl)-3-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-Chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-[1-(4-Cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 1-(5-Chlor-2- methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-Chlorphenyl)-3-[1-(3- cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-Fluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin- 3-yl)harnstoff, 1-(2-Chlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(5-Chlor-2- methylphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-Chlor-2-methylphenyl)-3-(1- cyclobutyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(2,5-Dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin- 3-yl]thioharnstoff, 1-[1-(4-Cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphenyl)thioharnstoff, 1- (2-Chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff. Einige der zuvor genannten substituierten Pyrrolidinone der allgemeinen Formel (I) sind ebenfalls noch nicht im Stand der Technik bekannt. Somit gelten als weiterer Teil der Erfindung substituierte N- Pyrrolidinone der allgemeinen Formel (I) oder deren Salze,
Figure imgf000052_0001
worin R1 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl steht, für Wasserstoff steht, R7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht,
Figure imgf000053_0001
R3, R4 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, OR32 stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, NR30R31, OR32, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl stehen, R8, R9, R10 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl-(C1-C8)-Alkyl, Heteroaryl-(C1-C8)-Alkyl, C(O=)R32, (C1-C8)-Alkyloxycarbonyl, Aryl- (C1-C8)-Alkyloxycarbonyl stehen, R11, R12 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)- Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C- (C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, OR32 stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)- Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1-C8)-Alkylthio-(C1-C8)- alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl- (C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C8)-Alkoxycarbonyl, Bis-[(C1- C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1- C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl, Heteroaryl-(C1-C8)- alkoxycarbonyl, (C2-C8)-Alkenyloxycarbonyl, (C2-C8)-Alkinyloxycarbonyl, (C1-C8)- Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)- Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)- alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)- alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)-Alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, Aryl, Aryl- (C1-C8)-alkyl, Aryl-(C1-C8)-alkoxy-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)- Cycloalkyl-(C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)- alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)- alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl- amino-(C2-C6)-alkyl, Aryl-(C1-C8)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C8)-alkyl, Hydroxycarbonyl-(C1-C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)- Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis- (aryl)silyl-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)- Cycloalkylcarbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy- (C1-C8)-alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, Aryloxy-(C1-C8)-alkyl, Heteroaryloxy- (C1-C8)-alkyl, Heterocyclyloxy-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl, (C1-C8)- Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)- Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)- alkoxycarbonyl-(C1-C8)-alkyl steht, R33 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)- alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl- (C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino, (C1-C8)-Alkyl-amino, Aryl-(C1-C8)- amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C8)-alkyl]amino; Heteroaryl-(C1-C8)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl-[(C1-C8)-alkyl]amino; Hetercyclyl-(C1-C8)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C8)-alkyl]amino; (C3-C8)-Cycloalkyl- amino, (C3-C8)-Cycloalkyl-[(C1-C8)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R37 für Phenyl, 2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6-Methylpyridin- 2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2-Methylphenyl, 2,6-Dichlorphenyl, 2- Chlorpyridin-4-yl, Pyridazin-4-yl, 2-(Trifluormethyl)phenyl, 2-Cyanophenyl, 2-Bromphenyl, 2- Iodphenyl, 5-Fluor-2-methylphenyl, 5-Brom-2-methylphenyl, Pyridin-3-yl, 2-Chlorpyridin-3-yl, 2-Fluorpyridin-4-yl, 2-Fluorpyridin-3-yl steht und für 0, 1, 2 steht. Bevorzugt sind Verbindungen der allgemeinen Formel (I), worin R1 für (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, Aryl, Aryl-(C1-C7)-Alkyl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C7)-Alkyl steht, R2 für Wasserstoff steht, R7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht,
Figure imgf000056_0001
R3, R4 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, OR32 stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)-Alkyl, NR30R31, OR32, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl stehen, R8, R9, R10 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl-(C1-C7)-Alkyl, Heteroaryl-(C1-C7)-Alkyl, C(O=)R32, (C1-C7)-Alkyloxycarbonyl, Aryl- (C1-C7)-Alkyloxycarbonyl stehen, R11, R12 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)- Alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C- (C1-C7)-Alkyl, R30R31N(O)C-(C1-C7)-Alkyl, OR32 stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)- Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)- Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkylthio-(C1-C7)-alkyl, (C1-C7)-Haloalkylthio-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)- alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)- Cycloalkenyl-(C1-C7)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C7)-Alkoxycarbonyl, Bis-[(C1- C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1- C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl, Heteroaryl-(C1-C7)- alkoxycarbonyl, (C2-C7)-Alkenyloxycarbonyl, (C2-C7)-Alkinyloxycarbonyl, (C1-C7)- Alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)- Alkinyloxycarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heteroaryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)- alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)-Alkoxy-(C1-C7)- alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)- Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, Aryl, Aryl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxy-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)- alkyl, (C1-C7)-Alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)- alkyl, Bis-[(C1-C7)-alkyl]amino-(C2-C6)-alkyl, (C1-C7)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C7)- alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C7)-alkyl, Hydroxycarbonyl-(C1-C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)- Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, (C1-C7)- Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkylcarbonyloxy-(C1-C7)-alkyl, Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)-alkyl, Heterocyclylcarbonyloxy-(C1-C7)-alkyl, Aryloxy-(C1-C7)-alkyl, Heteroaryloxy-(C1-C7)-alkyl, Heterocyclyloxy-(C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl, (C1-C7)-Alkoxycarbonyl-(C1-C7)- alkyl, (C2-C7)-Alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkinyloxycarbonyl-(C1-C7)- alkyl, Aryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heteroaryl-(C1-C7)-alkoxycarbonyl- (C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl steht, R33 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)- Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)- alkyl, Heterocyclyl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C10)-Cycloalkenyl- (C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]amino, (C1-C7)-Alkyl-amino, Aryl-(C1-C7)-amino, Aryl-(C1- C6)-alkyl-amino, Aryl-[(C1-C7)-alkyl]amino; Heteroaryl-(C1-C7)-amino, Heteroaryl-(C1-C6)- alkyl-amino, Heteroaryl-[(C1-C7)-alkyl]amino; Hetercyclyl-(C1-C7)-amino, Heterocyclyl-(C1- C6)-alkyl-amino, Heterocyclyl-[(C1-C7)-alkyl]amino; (C3-C7)-Cycloalkyl-amino, (C3-C7)- Cycloalkyl-[(C1-C7)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R37 für Phenyl, 2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6-Methylpyridin- 2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2-Methylphenyl, 2,6-Dichlorphenyl, 2- Chlorpyridin-4-yl, Pyridazin-4-yl, 2-(Trifluormethyl)phenyl, 2-Cyanophenyl steht und m für 0, 1, 2 steht. Besonders bevorzugt sind Verbindungen der allgemeinen Formel (I), worin R1 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C6)-Alkyl steht, R2 für Wasserstoff steht, R7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht,
Figure imgf000058_0001
R3, R4 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, OR32 stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, NR30R31, OR32, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl stehen, R8, R9, R10 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl- (C1-C6)-Alkyloxycarbonyl stehen, R11, R12 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)- Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C- (C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, OR32 stehen, R30 und R31 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C6)- Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl- aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)- alkoxycarbonyl, Heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)- Alkinyloxycarbonyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)- Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl- (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)- alkyl, Heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)- alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)- alkyl, Bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C6)- alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, Hydroxycarbonyl-(C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)- Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1-C6)- Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)-alkyl, Heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl- (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl steht, R33 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)- Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)- alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C10)-Cycloalkenyl- (C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1- C6)-alkyl-amino, Aryl-[(C1-C6)-alkyl]amino; Heteroaryl-(C1-C6)-amino, Heteroaryl-(C1-C6)- alkyl-amino, Heteroaryl-[(C1-C6)-alkyl]amino; Hetercyclyl-(C1-C6)-amino, Heterocyclyl-(C1- C6)-alkyl-amino, Heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)- Cycloalkyl-[(C1-C6)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R37 für Phenyl, l2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6-Methylpyridin- 2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2-Methylphenyl, 2,6-Dichlorphenyl, 2- Chlorpyridin-4-yl, Pyridazin-4-yl, 2-(Trifluormethyl)phenyl, 2-Cyanophenyl steht und m für 0, 1, 2 steht. Ganz besonders bevorzugt sind folgende Verbindungen der allgemeinen Formel (I): N-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphenyl)acetamid, 2-(2,5-dichlorphenyl)-N- [1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphenyl)acetamid, 2-(2,5-dichlorphenyl)-N- [1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(4-methoxyphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]acetamid, 2-(2-chlorphenyl)-N-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]acetamid, N-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphenyl)acetamid, 2-(2,5-dichlorphenyl)-N-[1-(3,5- difluorphenyl)-4-methyl-5-oxopyrrolidin-3-yl]acetamid, 2-(2-chlorphenyl)-N-[1-(3,5-difluorphenyl)-4- methyl-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-(5-oxo-1-phenylpyrrolidin-3- yl)acetamid, 2-(2,5-dichlorphenyl)-N-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5- dichlorphenyl)-N-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)acetamid, N-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamid, N-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]-2-(2- methylphenyl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylphenyl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamid, N-(1-cyclopropyl-5- oxopyrrolidin-3-yl)-2-(2,5-dichlorphenyl)acetamid, 2-(2-chlorphenyl)-N-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]acetamid, N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorphenyl)acetamid, 2- (2-methylphenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acetamid, 2-(2-chlorphenyl)-N-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]acetamid, N-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-2-(2,5- dimethylphenyl)acetamid, 2-(2,5-dimethylphenyl)-N-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acetamid, N-[1-(4-fluorphenyl)-5- oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamid, 2-(2,5-dimethylphenyl)-N-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)acetamid, N- [1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylphenyl)acetamid, 2-(2-chlorphenyl)-N-[1-(4- methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(1-isopropyl-5- oxopyrrolidin-3-yl)acetamid, N-(1-isopropyl-5-oxopyrrolidin-3-yl)-2-(2-methylphenyl)acetamid, 2-(2,5- dichlorphenyl)-N-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2-chlorphenyl)-N-(1- cyclobutyl-5-oxopyrrolidin-3-yl)acetamid, 2-(2-chlorphenyl)-N-[2-(2-chlorphenyl)acetyl]-N-(1- cyclobutyl-5-oxopyrrolidin-3-yl)acetamid, 2-(4-chlorphenyl)-N-[2-(4-chlorphenyl)acetyl]-N-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]acetamid, 1-(4-fluorphenyl)-3-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(4-brom-3-methylphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3- yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-chlorphenyl)- 3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-(5-oxo-1-phenylpyrrolidin- 3-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4- chlorphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(4-acetylphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorphenyl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2- methylphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-fluorphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(6-chlorpyridin-3-yl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(6- chlorpyridin-3-yl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(2-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(2-chlorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(4-chlorphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1- (2-chlorphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-acetylphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin- 3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,5- dimethylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(3-chlorphenyl)-5-oxopyrrolidin-3- yl]-3-(4-fluorphenyl)harnstoff, 1-[1-(2-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorphenyl)harnstoff, 1-(4-acetylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-methylpyridin-2-yl)harnstoff, 1-(6-chlorpyridin-3-yl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)harnstoff, 1-[1-(3-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)harnstoff, 1-(4-chlorphenyl)-3-(4-methyl-5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(6-methylpyridin-2-yl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1- (4-fluorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3- (5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]-3-(6- methylpyridin-2-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5- oxo-1-phenylpyrrolidin-3-yl)-3-pyridin-2-ylharnstoff, 1-(2-chlorphenyl)-3-[1-(4-methoxyphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-difluorphenyl)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5- oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 4-[4-[3-(2-chlorphenyl)-2,4,5-trioxoimidazolidin-1-yl]- 2-oxopyrrolidin-1-yl]benzonitril, 1-(2-fluorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5-oxopyrrolidin-3- yl]harnstoff, 1-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphenyl)harnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)imidazolidine-2,4,5-trion, 1-(5-chlor-2-methylphenyl)-3-(5-oxo-1-chinolin- 8-ylpyrrolidin-3-yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2- fluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-(5-oxo-1-chinolin- 8-ylpyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,5-difluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(3,5- difluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,5-difluorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-fluorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]imidazolidine-2,4,5-trion, 1-(2-chlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]imidazolidine-2,4,5-trion, 1-(2-chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3- yl)imidazolidine-2,4,5-trion, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)imidazolidine-2,4,5-trion, 3-[4-[3-(2-chlorphenyl)-2,4,5-trioxoimidazolidin-1-yl]-2- oxopyrrolidin-1-yl]benzonitril, 1-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)imidazolidine-2,4,5-trion, 1-(5-chlor-2-methylphenyl)-3-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5- oxopyrrolidin-3-yl]harnstoff, 1-(2,3-dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(2-fluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,6- difluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]-3-(2-methylphenyl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5-oxopyrrolidin-3- yl]harnstoff, 1-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 1-(2- chlorphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-fluorphenyl)-3-[1-(2- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-fluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3- yl)harnstoff, 1-(2-chlorphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)harnstoff, 1-[1-(3-cyanophenyl)- 5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 1-(2-chlorphenyl)-3-[1-(4-cyanophenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1- (2,5-difluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(3-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(2,6-dichlorphenyl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-methylpropyl)- 5-oxopyrrolidin-3-yl]harnstoff, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2,5-difluorphenyl)harnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-fluorphenyl)harnstoff, 1-(2,5-difluorphenyl)-3-(1-isopropyl- 5-oxopyrrolidin-3-yl)harnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-methylphenyl)harnstoff, 1- (1-cyclopropyl-5-oxopyrrolidin-3-yl)-3-(2,5-difluorphenyl)harnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3- yl)-3-(2,5-difluorphenyl)harnstoff, 1-(2-fluorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(2-methylphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,5- difluorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-(1- cyclobutyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3- yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2- chlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(1-cyclopropyl-5-oxopyrrolidin-3-yl)-3- (2-fluorphenyl)harnstoff, 1-(2-fluorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(1- cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2-fluorphenyl)harnstoff, 1-[1-(3-cyanophenyl)-5-oxopyrrolidin-3- yl]-3-(2,5-difluorphenyl)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl)harnstoff, 1-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5- difluorphenyl)harnstoff, 1-(2,6-difluorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5- chlor-2-methylphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-chlorphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3- yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(5-chlor-2- methylphenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-(1- isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorpyridin-4-yl)-3-[1-(4- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-pyridazin-4- ylharnstoff, 1-(4-fluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)harnstoff, 1-[1-(4-cyanophenyl)- 5-oxopyrrolidin-3-yl]-3-[2-(trifluormethyl)phenyl]harnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3- [2-(trifluormethyl)phenyl]harnstoff, 1-(2-cyanophenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3- yl)harnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-[2-(trifluormethyl)phenyl]harnstoff, 1-(2- chlorpyridin-4-yl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)harnstoff, 1-(5-oxo-1-phenylpyrrolidin-3-yl)- 3-[2-(trifluormethyl)phenyl]harnstoff, 1-(4-fluorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3-phenylharnstoff, 1-(2-chlorpyridin-4-yl)-3-[1- (4-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(4- fluorphenyl)harnstoff, 1-(2-cyanophenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2- cyanophenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorpyridin-4-yl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(2-cyanophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(1- isopropyl-5-oxopyrrolidin-3-yl)-3-phenylharnstoff.1-(4-fluorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3- yl)harnstoff., 1-(2-cyanophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(1-isopropyl-5- oxopyrrolidin-3-yl)-3-[2-(trifluormethyl)phenyl]harnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3- pyridazin-4-ylharnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3-pyridazin-4-ylharnstoff, 1-(5-oxo-1- phenylpyrrolidin-3-yl)-3-pyridazin-4-ylharnstoff, 1-(1-isopropyl-5-oxopyrrolidin-3-yl)-3-pyridazin-4- ylharnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-phenylharnstoff, 1-(2,5-dichlorphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin- 3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1- (2,5-dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1- (3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3- cyanophenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-fluorphenyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3- yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3- yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1- [1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphenyl)thioharnstoff, 1-(5-chlor-2- methylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)thioharnstoff, 1-(2,4-dichlorphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)thioharnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(2-methylpropyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]thioharnstoff, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2,5-dichlorphenyl)thioharnstoff, 1-[1-(4- cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphenyl)thioharnstoff, 1-(5-chlor-2-methylphenyl)-3- (1-cyclopropyl-5-oxopyrrolidin-3-yl)thioharnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,4- dichlorphenyl)thioharnstoff, 1-(2-chlorphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)thioharnstoff, 1- (2,5-dichlorphenyl)-3-[1-(3,5-difluorphenyl)-4-methyl-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2- chlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2-chlorphenyl)-3-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2-chlorphenyl)-3-[1-(2-methylpropyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3- yl)thioharnstoff, 1-(2-chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(1- cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2,5-dichlorphenyl)thioharnstoff, 1-(2-chlorphenyl)-3-(1-cyclobutyl- 5-oxopyrrolidin-3-yl)thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin- 3-yl]thioharnstoff, 1-(2,4-dichlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)thioharnstoff, 1-(5-chlor- 2-methylphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)thioharnstoff. Im Speziellen bevorzugt sind folgende Verbindungen der allgemeinen Formel (I): N-[1-(4-Cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphenyl)acetamid, 2-(2,5-Dichlorphenyl)-N- [1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamid, N-(1-Cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5- dichlorphenyl)acetamid, 2-(2,5-Dichlorphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)acetamid, 2-(2,5- Dimethylphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)acetamid, N-(1-Isopropyl-5-oxopyrrolidin-3-yl)- 2-(2-methylphenyl)acetamid, 2-(2-Chlorphenyl)-N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)acetamid, 1-(5- Chlor-2-methylphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-Chlor-2- methylphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(6-Chlorpyridin-3-yl)-3-[1-(4- methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-Chlor-2-methylphenyl)-3-(4-methyl-5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(4-Chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3- yl)harnstoff, 1-(5-Chlor-2-methylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(5-Chlor-2- methylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-Chlorphenyl)-3-[1-(4- methoxyphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-Cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)harnstoff, 1-(5-Chlor-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(2-Chlorphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2- Fluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(2-Chlorphenyl)-3-(1-isopropyl-5- oxopyrrolidin-3-yl)harnstoff, 1-(5-Chlor-2-methylphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-Chlor-2-methylphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(2,5- Dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-[1-(4-Cyanophenyl)-5- oxopyrrolidin-3-yl]-3-(2,5-dichlorphenyl)thioharnstoff, 1-(2-Chlorphenyl)-3-[1-(4-methoxyphenyl)-5- oxopyrrolidin-3-yl]thioharnstoff. Außerdem sind einige weitere der zuvor genannten substituierten Pyrrolidinone der allgemeinen Formel (I) noch nicht im Stand der Technik bekannt. Somit gelten als weiterer Teil der Erfindung substituierte N-Pyrrolidinone der allgemeinen Formel (I) oder deren Salze,
Figure imgf000066_0001
worin R1 für (3-Methylphenyl)methyl, (4-Methylphenyl)methyl, (2-Methylphenyl)methyl, (3- Trifluormethylphenyl)methyl, (4-Trifluorethylphenyl)methyl, (2-Trifluormethylphenyl)methyl, (3-Chlorphenyl)methyl, (4-Chlorphenyl)methyl, (3-Fluorphenyl)methyl, (4-Fluorphenyl)methyl, (2-Fluorphenyl)methyl, (3,4-Difluorphenyl)methyl, (3,4-Dichlorphenyl)methyl, (3-Fluor-4- chlorphenyl) methyl, (3-Chlor-4-fluorphenyl)methyl, (3,4-Dimethylphenyl)methyl, (3,5- Difluorphenyl)methyl, (3,5-Dichlorphenyl)methyl, (3-Fluor-5-chlorphenyl) methyl, (3-Chlor-5- fluorphenyl)methyl, (3,5-Dimethylphenyl)methyl, (3,5-Ditrifluormethylphenyl)methyl, (3- Fluor-5-trifluormethylphenyl) methyl, (3-Trifluormethyl-5-fluorphenyl)methyl, (3-Chlor-5- trifluormethylphenyl) methyl, (3-Trifluormethyl-5-Chlorphenyl)methyl steht, R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht
Figure imgf000066_0002
R7 für Wasserstoff steht R3, R4 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, NR30R31, OR32, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl stehen, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)- Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C- (C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, OR32 stehen, R15 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl-(C1-C8)-Alkyl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)- Cycloalkyl-(C1-C8)-Alkyl, S(O)mR33, R32(O=)C-(C1-C8)-Alkyl, C(O=)R32, R32O(O)C-(C1-C8)- Alkyl, R30R31N(O)C-(C1-C8)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)- Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1-C8)-Alkylthio-(C1-C8)- alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl- (C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C8)-Alkoxycarbonyl, Bis-[(C1- C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1- C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl, Heteroaryl-(C1-C8)- alkoxycarbonyl, (C2-C8)-Alkenyloxycarbonyl, (C2-C8)-Alkinyloxycarbonyl, (C1-C8)- Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)- Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)- alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)- alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)-Alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, Aryl, Aryl- (C1-C8)-alkyl, Aryl-(C1-C8)-alkoxy-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)- Cycloalkyl-(C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)- alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)- alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl- amino-(C2-C6)-alkyl, Aryl-(C1-C8)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C8)-alkyl, Hydroxycarbonyl-(C1-C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)- Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis- (aryl)silyl-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)- Cycloalkylcarbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy- (C1-C8)-alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, Aryloxy-(C1-C8)-alkyl, Heteroaryloxy- (C1-C8)-alkyl, Heterocyclyloxy-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl, (C1-C8)- Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)- Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)- alkoxycarbonyl-(C1-C8)-alkyl steht und R33 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)- alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl- (C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino, (C1-C8)-Alkyl-amino, Aryl-(C1-C8)- amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C8)-alkyl]amino; Heteroaryl-(C1-C8)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl-[(C1-C8)-alkyl]amino; Hetercyclyl-(C1-C8)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C8)-alkyl]amino; (C3-C8)-Cycloalkyl- amino, (C3-C8)-Cycloalkyl-[(C1-C8)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht. R35 für Wasserstoff, NR30R31, OR32, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl- (C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, S(O)mR33, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m- (C1-C8)-alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht, R36 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)- Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)- Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O-(C1-C8)-Alkyl, R30R31N- (C1-C8)-Alkyl steht und m für 0, 1, 2 steht. Bevorzugt sind Verbindungen der allgemeinen Formel (I), worin R1 für (3-Methylphenyl)methyl, (4-Methylphenyl)methyl, (2-Methylphenyl)methyl, (3- Trifluormethylphenyl)methyl, (4-Trifluorethylphenyl)methyl, (2-Trifluormethylphenyl)methyl, (3-Chlorphenyl)methyl, (4-Chlorphenyl)methyl, (3-Fluorphenyl)methyl, (4-Fluorphenyl)methyl, (2-Fluorphenyl)methyl, (3,4-Difluorphenyl)methyl, (3,4-Dichlorphenyl)methyl, (3-Fluor-4- chlorphenyl) methyl, (3-Chlor-4-fluorphenyl)methyl, (3,4-Dimethylphenyl)methyl, (3,5- Difluorphenyl)methyl, (3,5-Dichlorphenyl)methyl, (3-Fluor-5-chlorphenyl) methyl, (3-Chlor-5- fluorphenyl)methyl, (3,5-Dimethylphenyl)methyl, (3,5-Ditrifluormethylphenyl)methyl, (3- Fluor-5-trifluormethylphenyl) methyl, (3-Trifluormethyl-5-fluorphenyl)methyl, (3-Chlor-5- trifluormethylphenyl) methyl, (3-Trifluormethyl-5-Chlorphenyl)methyl steht, R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht G-1 G-2 R7 für Wasserstoff steht R3, R4 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)-Alkyl, NR30R31, OR32, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl stehen, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)- Alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C- (C1-C7)-Alkyl, R30R31N(O)C-(C1-C7)-Alkyl, OR32 stehen, R15 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl-(C1-C7)-Alkyl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, (C3-C7)-Cycloalkyl- (C1-C7)-Alkyl, S(O)mR33, R32(O=)C-(C1-C7)-Alkyl, C(O=)R32, R32O(O)C-(C1-C7)-Alkyl, R30R31N(O)C-(C1-C7)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)- Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C7)- Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkylthio-(C1-C7)-alkyl, (C1-C7)-Haloalkylthio-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)- alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)- Cycloalkenyl-(C1-C7)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C7)-Alkoxycarbonyl, Bis-[(C1- C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1- C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl, Heteroaryl-(C1-C7)- alkoxycarbonyl, (C2-C7)-Alkenyloxycarbonyl, (C2-C7)-Alkinyloxycarbonyl, (C1-C7)- Alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)- Alkinyloxycarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heteroaryl- (C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)- Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)- alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)-Alkoxy- (C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, Aryl, Aryl- (C1-C7)-alkyl, Aryl-(C1-C7)-alkoxy-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)- Cycloalkyl-(C1-C7)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)- alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)- alkyl-aminocarbonyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]amino-(C2-C6)-alkyl, (C1-C7)-Alkyl- amino-(C2-C6)-alkyl, Aryl-(C1-C7)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C7)-alkyl, Hydroxycarbonyl-(C1-C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, Tris-[(C1-C7)- Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis- (aryl)silyl-(C1-C7)-alkyl, (C1-C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)- Cycloalkylcarbonyloxy-(C1-C7)-alkyl, Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy- (C1-C7)-alkyl, Heterocyclylcarbonyloxy-(C1-C7)-alkyl, Aryloxy-(C1-C7)-alkyl, Heteroaryloxy- (C1-C7)-alkyl, Heterocyclyloxy-(C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl, (C1-C7)- Alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)- Alkinyloxycarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heteroaryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)- alkoxycarbonyl-(C1-C7)-alkyl steht und R33 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)- Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)- alkyl, Heterocyclyl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C10)-Cycloalkenyl- (C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]amino, (C1-C7)-Alkyl-amino, Aryl-(C1-C7)-amino, Aryl-(C1- C6)-alkyl-amino, Aryl-[(C1-C7)-alkyl]amino; Heteroaryl-(C1-C7)-amino, Heteroaryl-(C1-C6)- alkyl-amino, Heteroaryl-[(C1-C7)-alkyl]amino; Hetercyclyl-(C1-C7)-amino, Heterocyclyl-(C1- C6)-alkyl-amino, Heterocyclyl-[(C1-C7)-alkyl]amino; (C3-C7)-Cycloalkyl-amino, (C3-C7)- Cycloalkyl-[(C1-C7)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht. R35 für Wasserstoff, NR30R31, OR32, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl, Aryl- (C1-C7)-Alkyl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, S(O)mR33, R32(O=)C-(C1-C7)-Alkyl, R32O(O)C-(C1-C7)-Alkyl, R30R31N(O)C-(C1-C7)-Alkyl, R33S(O)m- (C1-C7)-alkyl, R32O-(C1-C7)-Alkyl, R30R31N-(C1-C7)-Alkyl steht, R36 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl, Aryl-(C1-C7)-Alkyl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, (C3-C7)- Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, R32(O=)C-(C1-C7)-Alkyl, R32O(O)C-(C1-C7)- Alkyl, R30R31N(O)C-(C1-C7)-Alkyl, R33S(O)m-(C1-C7)-alkyl, R32O-(C1-C7)-Alkyl, R30R31N- (C1-C7)-Alkyl steht und m für 0, 1, 2 steht. Besonders bevorzugt sind Verbindungen der allgemeinen Formel (I), worin R1 für (3-Methylphenyl)methyl, (4-Methylphenyl)methyl, (2-Methylphenyl)methyl, (3- Trifluormethylphenyl)methyl, (4-Trifluorethylphenyl)methyl, (2-Trifluormethylphenyl)methyl, (3-Chlorphenyl)methyl, (4-Chlorphenyl)methyl, (3-Fluorphenyl)methyl, (4-Fluorphenyl)methyl, (2-Fluorphenyl)methyl, (3,4-Difluorphenyl)methyl, (3,4-Dichlorphenyl)methyl, (3-Fluor-4- chlorphenyl) methyl, (3-Chlor-4-fluorphenyl)methyl, (3,4-Dimethylphenyl)methyl, (3,5- Difluorphenyl)methyl, (3,5-Dichlorphenyl)methyl, (3-Fluor-5-chlorphenyl) methyl, (3-Chlor-5- fluorphenyl)methyl, (3,5-Dimethylphenyl)methyl, (3,5-Ditrifluormethylphenyl)methyl, (3- Fluor-5-trifluormethylphenyl) methyl, (3-Trifluormethyl-5-fluorphenyl)methyl, (3-Chlor-5- trifluormethylphenyl) methyl, (3-Trifluormethyl-5-Chlorphenyl)methyl steht, R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht,
Figure imgf000073_0001
R7 für Wasserstoff steht, R3, R4 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl,, Aryl stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, NR30R31, OR32, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl stehen, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)- Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C- (C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, OR32 stehen, R15 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, C(O=)R32, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)- Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C6)-Alkoxycarbonyl, Bis-[(C1- C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1- C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl, Heteroaryl-(C1-C6)- alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)-Alkinyloxycarbonyl, (C1-C6)- Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)- Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)- alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)- Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)- alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy- (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl- (C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)- alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)- alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl- amino-(C2-C6)-alkyl, Aryl-(C1-C6)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, Hydroxycarbonyl-(C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)- Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis- (aryl)silyl-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)- Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy- (C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy- (C1-C6)-alkyl, Heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl, (C1-C6)- Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)- Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)- alkoxycarbonyl-(C1-C6)-alkyl steht, R33 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C10)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)- Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)- alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1- C6)-alkyl-amino, Aryl-[(C1-C6)-alkyl]amino; Heteroaryl-(C1-C6)-amino, Heteroaryl-(C1-C6)- alkyl-amino, Heteroaryl-[(C1-C6)-alkyl]amino; Hetercyclyl-(C1-C6)-amino, Heterocyclyl-(C1- C6)-alkyl-amino, Heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)- Cycloalkyl-[(C1-C6)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R35 für Wasserstoff, NR30R31, OR32, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl- (C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, R33S(O)m- (C1-C6)-alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl steht, R36 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, (C3-C6)- Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)- Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32O-(C1-C6)-Alkyl, R30R31N- (C1-C6)-Alkyl steht und für 0, 1, 2 steht. Ganz besonders bevorzugt sind Verbindungen der allgemeinen Formel (I), worin R1 für (3-Methylphenyl)methyl, (4-Methylphenyl)methyl, (2-Methylphenyl)methyl, (3- Trifluormethylphenyl)methyl, (4-Trifluorethylphenyl)methyl, (2-Trifluormethylphenyl)methyl, (3-Chlorphenyl)methyl, (4-Chlorphenyl)methyl, (3-Fluorphenyl)methyl, (4-Fluorphenyl)methyl, (2-Fluorphenyl)methyl, (3,4-Difluorphenyl)methyl, (3,4-Dichlorphenyl)methyl, (3-Fluor-4- chlorphenyl) methyl, (3-Chlor-4-fluorphenyl)methyl, (3,4-Dimethylphenyl)methyl, (3,5- Difluorphenyl)methyl, (3,5-Dichlorphenyl)methyl, (3-Fluor-5-chlorphenyl) methyl, (3-Chlor-5- fluorphenyl)methyl, (3,5-Dimethylphenyl)methyl, (3,5-Ditrifluormethylphenyl)methyl, (3- Fluor-5-trifluormethylphenyl) methyl, (3-Trifluormethyl-5-fluorphenyl)methyl, (3-Chlor-5- trifluormethylphenyl) methyl, (3-Trifluormethyl-5-Chlorphenyl)methyl steht, R2 für eine der oben genannten Gruppen G-1 und G-2 steht, wobei X für die Gruppierung O-R36 und N(R15)R35 in den Gruppen G-1 und G-2 steht und die unten beschriebene Bedeutung hat und wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht,
Figure imgf000076_0001
aus G-1 R7 für Wasserstoff steht, R3, R4 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, 1-Methylethy-1-yl, Difluormethyl stehen, R5, R6 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, 1-Methyleth-1-yl, 1,1-Dimethyleth-1- yl, Phenyl, 4-Fluorphenyl, 4-Chlorphenyl, Hydroxy, Methoxy, Trifluormethyloxy stehen, R13, R14 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, 1-Methyleth-1-yl, 1,1-Dimethyleth-1- yl stehen und, X für OH, (1-methyl-1H-1,2,4-triazol-5-yl)amino, (1-ethyl-1H-1,2,4-triazol-5-yl)amino, (1- methyl-1H-tetrazol-5-yl)amino, (1-ethyl-1H-tetrazol-5-yl)amino, [1-carboxy-2- methylbutyl]amino, [(1S,2S)-1-carboxy-2-methylbutyl]amino, [(1R,2S)-1-carboxy-2- methylbutyl]amino, [(1R,2R)-1-carboxy-2-methylbutyl]amino, [(1S,2R)-1-carboxy-2- methylbutyl]amino, (5-methoxy-2,5-dioxopentyl)amino, 2-(4-fluorphenoxy)ethoxy; methoxy; 2- methylsulfonylethoxy; 2-methylsulfanylethoxy; methanesulfonamido; 2-carboxypyrrolidin-1-yl, 2-methoxyethoxy, cyclopentyloxy, 2,2-dimethylpropoxy, ethoxy, cyclopropylmethoxy, prop-2- en-1-yloxy, 2-phenylsulfanylethoxy, prop-2-yn-1-yloxy, cyclobutyloxy, isopropyloxy, but-3- enoxy, 2-phenoxyethoxy, pentan-2-yloxy, 2-(4-chlorphenyl)sulfinylethoxy, butan-2-yloxy, 2-(4- methoxyphenoxy)ethoxy, 2-(benzenesulfonyl)ethoxy, 2-(4-chlorphenoxy)ethoxy, 2-(4- methylphenoxy)ethoxy, 3-methylbutan-2-yloxy, [3-(1H-imidazol-4-yl)-1-methoxy-1- oxopropan-2-yl]amino, [(2R)-3-(1H-imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl]amino, [(2S)- 3-(1H-imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl]amino, 2-[(4-chlorphenyl)thio]ethoxy, [1- carboxy-2-phenylethyl]amino, [(1R)-1-carboxy-2-phenylethyl]amino, [(1S)-1-carboxy-2- phenylethyl]amino, [1-carboxy-2-(4-hydroxyphenyl)ethyl]amino, [(1R)-1-carboxy-2-(4- hydroxyphenyl)ethyl]amino, [(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino, [1-carboxy-2- (4-methoxyphenyl)ethyl]amino, [(1R)-1-carboxy-2-(4-methoxyphenyl)ethyl]amino, [(1S)-1- carboxy-2-(4-methoxyphenyl)ethyl]amino, 2-[(4-methoxyphenyl)thio]ethoxy, 2-[(4- methylphenyl)thio]ethoxy, [1-carboxy-3-methylbutyl]amino, [(1R)-1-carboxy-3- methylbutyl]amino, [(1S)-1-carboxy-3-methylbutyl]amino, (4-methyl-1,2,5-oxadiazol-3- yl)amino, 2-(4-methylphenyl)sulfinylethoxy, [1-(methoxycarbonyl)cyclopropyl]amino, 2- hydroxyethylamino, [3-(1H-imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl]amino, [(2S)-3-(1H- imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl]amino, [(2R)-3-(1H-imidazol-4-yl)-1-methoxy-1- oxopropan-2-yl]amino, [1-carboxy-2-methoxyethyl]amino, [(1R)-1-carboxy-2- methoxyethyl]amino, [(1S)-1-carboxy-2-methoxyethyl]amino, [1-carboxy-2- methylthioethyl]amino, [(1R)-1-carboxy-2-methylthioethyl]amino, [(1S)-1-carboxy-2- methylthioethyl]amino, [1-carboxyethyl]amino, [(1R)-1-carboxyethyl]amino, [(1S)-1- carboxyethyl]amino, [1-carboxy-2-methylpropyl]amino, [(1R)-1-carboxy-2- methylpropyl]amino, [(1S)-1-carboxy-2-methylpropyl]amino, trifluormethylsulfonylamino, (2- methoxy-2-oxoethyl)-methylamino, 2-(4-methoxyphenyl)sulfonylethoxy, benzylamino, 2- methylpropylamino, amino, 2,2-dimethylhydrazino, hydrazino, prop-2-en-1-ylamino, 2-(4- methoxyphenyl)sulfinylethoxy, 2-phenylethylamino, (6-chlorpyridin-3-yl)methyl-methylamino, (4-methoxy-4-oxobutan-2-yl)amino, [(2S)-4-methoxy-4-oxobutan-2-yl)]amino, [(2R)-4- methoxy-4-oxobutan-2-yl)]amino, [2-isopropyl-5-methylcyclohexyl]oxy, [(1S,2R,5S)-2- isopropyl-5-methylcyclohexyl]oxy, [(1S,2R,5R)-2-isopropyl-5-methylcyclohexyl]oxy, [(1R,2R,5S)-2-isopropyl-5-methylcyclohexyl]oxy, [(1R,2R,5R)-2-isopropyl-5- methylcyclohexyl]oxy, [(1S,2S,5S)-2-isopropyl-5-methylcyclohexyl]oxy, [(1S,2S,5R)-2- isopropyl-5-methylcyclohexyl]oxy, [(1R,2S,5S)-2-isopropyl-5-methylcyclohexyl]oxy, [(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]oxy, 1,2,3,4-tetrahydronaphthalen-1-ylamino, [1- carboxy-2-(1H-indol-3-yl)ethyl]amino, [(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino, [(1R)-1- carboxy-2-(1H-indol-3-yl)ethyl]amino, pyrrolidin-1-yl, ethylsulfonylamino, diethylamino, difluormethylsulfonylamino, isopropylsulfonylamino, pyridin-2-ylmethylamino, chinolin-5- ylmethylamino, 2-(methoxycarbonyl)anilino, 2-(3,4-dichlorphenyl)ethylamino, 2,2,2, trifluorethylsulfonylamino, dimethylsulfamoylamino, (3-methoxy-3-oxopropyl)amino, (1-ethyl- 1H-pyrazol-3-yl)methylamino, cyclopropylsulfonylamino, tert-butoxy, 2,2,2-trifluorethylamino, 2-methoxyethylamino, ethoxyethylamino, prop-2-yn-1-ylamino, (2-ethylphenyl)methylamino, (1-ethyl-3-methyl-1H-pyrazol-4-yl)methylamino, 3-methylbutylamino, 2-(2- bromphenyl)ethylamino, ethylamino, 2-(3,5-dimethoxyphenyl)ethylamino, N-methylanilino, methylsulfonylazanidyl, (6-chlorpyridin-3-yl)methylamino, 2-(2,4-difluorphenyl)ethylamino, methylamino, [2,6-dimethylindan-1-yl]amino, [(1R,2S)-2,6-dimethylindan-1-yl]amino, [(1R,2R)-2,6-dimethylindan-1-yl]amino, [(1S,2S)-2,6-dimethylindan-1-yl]amino, [(1S,2R)-2,6- dimethylindan-1-yl]amino, 2-(1,3-benzodioxol-5-yl)ethylamino, butan-2-ylamino, 2-(1H-indol- 3-yl)ethylamino, propylamino, 2-(2,6-difluorphenyl)ethylamino, 2-(3-methylphenyl)ethylamino, 2-[3-(trifluormethoxy)phenyl]ethylamino, indan-1-ylamino, chinolin-6-ylmethylamino, [1-tert- butoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2S)-1-tert-butoxy-3-(4- hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2R)-1-tert-butoxy-3-(4-hydroxyphenyl)-1- oxopropan-2-yl]amino, [1-methoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2S)-1- methoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2R)-1-methoxy-3-(4- hydroxyphenyl)-1-oxopropan-2-yl]amino, [1-tert-butoxy-3-phenyl-1-oxopropan-2-yl]amino, [(2S)-1-tert-butoxy-3-phenyl-1-oxopropan-2-yl]amino, [(2R)-1-tert-butoxy-3-phenyl-1- oxopropan-2-yl]amino, [1-methoxy-3-phenyl-1-oxopropan-2-yl]amino, [(2S)-1-methoxy-3- phenyl-1-oxopropan-2-yl]amino, [(2R)-1-methoxy-3-(4-hydroxyphenyl)-1-oxopropan-2- yl]amino, 2-(4-tert-butylphenyl)ethylamino, cyclopropylamino, isopropylamino, 2- (ethoxycarbonyl)piperidin-1-yl, (1-n-propyl-1H-1,2,4-triazol-5-yl)amino, 2-(2- fluorphenyl)ethylamino, (2-methoxy-2-oxoethyl)-methylamino, 2-(ethoxycarbonyl)piperidin-1- yl, benzhydrylamino, dimethylsulfamoylamino, N-propylanilino, cyclobutylamino, cyclohexylmethylamino, N-ethylanilino, (2-methoxy-2-oxoethyl)-methylamino, 2- (ethoxycarbonyl)piperidin-1-yl, 3-(diethylamino)propylamino, (2,4-difluorphenyl)methylamino, 2-(5-hydroxy-1H-indol-3-yl)ethylamino, anilino, cyclopentylamino, cyclohexylamino, 2-[3- (trifluormethyl)phenyl]ethylamino, 2-(diethylamino)ethylamino, isochinolin-5-ylmethylamino, carboxymethyl(methyl)amino, 2-(4-fluorphenyl)ethylamino, 2-(5-methoxy-1H-indol-3- yl)ethylamino, carboxymethyl(ethyl)amino, 2-[4-(trifluormethoxy)phenyl]ethylamino, 2-(3- bromphenyl)ethylamino, 2-(2,5-dichlorphenyl)ethylamino, 2-thiophen-2-ylethylamino, 2-(2- methoxyphenyl)ethylamino, 2-(3,4-dimethoxyphenyl)ethylamino, (4-methoxy-4- oxobutyl)amino, 2-(4-chlorphenyl)ethylamino, 2-pyridin-3-ylethylamino, 2-[3-chlor-5- (trifluormethyl)pyridin-2-yl]ethylamino, cyclopentylsulfonylamino, 2-(4- methoxyphenyl)ethylamino, 2-(3-methoxyphenyl)ethylamino, 2-(2,3-dichlorphenyl)ethylamino, 2-[3,5-bis(trifluormethyl)phenyl]ethylamino, 2-(4-methylphenyl)ethylamino, 2-(3- chlorphenyl)ethylamino, 2-(2-chlorphenyl)ethylamino, 2-pyridin-2-ylethylamino, 2-(2,4- dichlorphenyl)ethylamino, 2-(3-fluorphenyl)ethylamino, 2,2-difluorethylamino, 1,3-dimethoxy- 1,3-dioxopropan-2-yl, 5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl, 3,3-dimethyl-2,6- dioxocyclohexyl, 4,4-dimethyl-2,6-dioxocyclohexyl, 4-methyl-2,6-dioxocyclohexyl, 2,5- dioxocyclopentyl, dicyanomethyl, 2,4-dioxo-3-bicyclo[3.2.1]octanyl, 3,3,5,5-tetramethyl-2,4,6- trioxocyclohexyl, 2,6-dioxocyclohexyl, 2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl, 5-hydroxy-1- methyl-1H-pyrazol-4-yl, 1-cyano-2-methoxy-2-oxoethyl, 1-methoxy-1,3-dioxobutan-2-yl, 2,4- dioxo-3-bicyclo[3.2.1]oct-6-enyl, phenylsulfonyl, ethoxyethoxy, methoxyethoxyethoxy, hydroxyethoxy, hydroxyethoxyethoxy, hydroxyethoxyethoxyethoxy, cyclopropylmethoxy, cyclobutylmethoxy, cyclopentylmethoxy, cyclohexylmethoxy, cyclopropylmethylamino, cyclobutylmethylamino, cyclopentylmethylamino, cyclohexylmethylamino, oxetan-3-yloxy, oxetan-3-ylamino, tetrahydrofuran-2-yloxy, tetrahydrofuran-3-yloxy, tetrahydrofuran-2- ylmethoxy, tetrahydrofuran-3-ylmethoxy, tetrahydrofuran-2-ylamino, tetrahydrofuran-3- ylamino, tetrahydrofuran-2-ylmethylamino, tetrahydrofuran-3-ylmethylamino, benzyloxy, 4- fluorbenzyloxy, 4-chlorbenzyloxy, 3-fluorbenzyloxy, 3-chlorbenzyloxy, 2-fluorbenzyloxy, 2- chlorbenzyloxy, 4-fluorbenzylamino, 4-chlorbenzylamino, 3-fluorbenzylamino, 3- chlorbenzylamino, 2-fluorbenzylamino, 2-chlorbenzylamino, pyridin-3-ylmethylamino, pyridin- 4-ylmethylamino, 4-chlor-pyridin-2-ylmethylamino, 4-chlor-pyridin-3-ylmethylamino, 4- trifluormethyl-pyridin-3-ylmethylamino, pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4- ylmethoxy, 4-chlor-pyridin-2-ylmethoxy, 4-chlor-pyridin-3-ylmethoxy, cyanomethylamino, cyanomethoxy, cyanoethoxy, hydroxycarbonylmethylamino, hydroxycarbonylmethoxy, hydroxycarbonylethoxy, hydroxycarbonylethylamino, methoxycarbonylmethylamino, ethoxycarbonylmethylamino, azetidin-1-yl-amino, pyrrolidin-1-ylamino, piperidin,-1-ylamino, ethylthioethoxy, 1,2,4-thiadiazol-5-ylamino, 5-(difluormethyl)-1,3,4-thiadiazol-2-ylamino, 5- tert-butyl-1,2-oxazol-3-ylamino, 4-(trifluormethyl)pyridin-2-ylamino, 5-chlor-4- (trifluormethyl)pyridin-2-ylamino, (pyridin-4-ylmethoxy)amino, hydroxyamino, methoxyamino, ethoxyamino, benzyloxyamino, methyl(methoxy)amino, methoxycarbonylmethoxyamino, ethoxycarbonylmethoxyamino, methoxycarbonylethoxyamino, ethoxycarbonylethoxyamino, hydroxycarbonylmethoxyamino, hydroxycarbonylethoxyamino, benzyloxycarbonylmethoxyamino, benzyloxycarbonylmethoxyamino, (1,1-dimethyleth-1- yl)oxycarbonylmethoxyamino, (1,1-dimethyleth-1-yl)oxycarbonylmethoxyamino steht. Im Speziellen bevorzugt sind folgende Verbindungen der allgemeinen Formel (I): 4-[2-[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]oxyethoxy]benzoesäure, 2-(4- Formylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2R)-2-[[2-[1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylsulfanylbuttersäure, 2-(4- ethylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(4- methylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N-Benzyl-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, Butan-2-yl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, (2S)-3-(1H-Indol-3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]propionsäure, N-Butan-2-yl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, (2R)-4-Methyl-2-[[2-[(2R)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]pentancarbonsäure, (2S)-2-[[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-3-phenylpropionsäure, (2R)-1-[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]pyrrolidin-2-carbonsäure, (2S)-2-[[2-[(2S)-1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-3-phenylpropionsäure, Methyl 2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]benzoat, N-Cyclopropyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-(Isochinolin-5-ylmethyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(2- Bromphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, (2R)-3-(1H-indol-3- yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionsäure, N-[2-(1H- indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(quinolin-6-ylmethyl)acetamid, N-[2-(5-hydroxy-1H- indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[(1-ethyl-1H- pyrazol-3-yl)methyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2- (Diethylamino)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, (2S,3S)-3-Methyl- 2-[[2-[(2S)-1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentancarbonsäure, 2-[1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]propionsäure, Methyl (2S)-3-(1H-imidazol-4-yl)-2-[[2- [(2R)-1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionat, 2-[1-[(4- fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]essigsäure, 2-[1-[(3-Fluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]essigsäure, Methyl-2-[1-[(3,4-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]propionat, N-[2-[3-Chlor-5-(trifluormethyl)pyridin-2-yl]ethyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid. Die oben aufgeführten allgemeinen oder in Vorzugsbereichen aufgeführten Restedefinitionen gelten sowohl für die Endprodukte der Formel (I) als auch entsprechend für die jeweils zur Herstellung benötigten Ausgangs- oder Zwischenprodukte. Diese Restedefinitionen können untereinander, also auch zwischen den angegebenen bevorzugten Bereichen, beliebig kombiniert werden. Vor allem aus den Gründen der erhöhten Stresstoleranz und/oder besseren Herstellbarkeit sind erfindungsgemäße Verbindungen der genannten Formel (I) oder deren Salze bzw. deren erfindungsgemäße Verwendung von besonderem Interesse, worin einzelne Reste eine der bereits genannten oder im folgenden genannten bevorzugten Bedeutungen haben, oder insbesondere solche, worin eine oder mehrere der bereits genannten oder im Folgenden genannten bevorzugten Bedeutungen kombiniert auftreten. Im Hinblick auf die erfindungsgemäßen Verbindungen werden die vorstehend und weiter unten verwendeten Bezeichnungen erläutert. Diese sind dem Fachmann geläufig und haben insbesondere die im Folgenden erläuterten Bedeutungen: Sofern nicht anders definiert, gilt generell für die Bezeichnung von chemischen Gruppen, dass die Anbindung an das Gerüst bzw. den Rest des Moleküls über das zuletzt genannte Strukturelement der betreffenden chemischen Gruppe erfolgt, d.h. beispielsweise im Falle von (C2-C8)-Alkenyloxy über das Sauerstoffatom, und im Falle von Heterocyclyl-(C1-C8)-alkyl oder R32O(O)C-(C1-C8)-Alkyl jeweils über das C-Atom der Alkylgruppe. In einer zusammengesetzten chemischen Gruppe wie z. B. Heterocyclyl- (C1-C8)-alkyl oder R32O(O)C-(C1-C8)-Alkyl steht die Bezeichnung “Alkyl” daher auch für eine Alkylengruppe. Bei den funktionellen Gruppen C(=O)R32, C(=O)OR32, C(=O)NR30R31, NR30R31, OR32, S(O)mR33 erfolgt die Anbindung an das Gerüst bzw. den Rest des Moleküls über das zuerst genannte Strukturelement der betreffenden chemischen Gruppe. Erfindungsgemäß steht "Alkylsulfonyl" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes Alkylsulfonyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, z.B. (aber nicht beschränkt auf) (C1-C6)-Alkylsulfonyl wie Methylsulfonyl, Ethyl- sulfonyl, Propylsulfonyl, 1-Methylethylsulfonyl, Butylsulfonyl, 1-Methylpropylsulfonyl, 2-Methyl- propylsulfonyl, 1,1-Dimethylethylsulfonyl, Pentylsulfonyl, 1-Methylbutylsulfonyl, 2-Methylbutyl- sulfonyl, 3-Methylbutylsulfonyl, 1,1-Dimethylpropylsulfonyl, 1,2-Dimethylpropylsulfonyl, 2,2-Di- methylpropylsulfonyl, 1-Ethylpropylsulfonyl, Hexylsulfonyl, 1-Methylpentylsulfonyl, 2-Methyl- pentylsulfonyl, 3-Methylpentylsulfonyl, 4-Methylpentylsulfonyl, 1,1-Dimethylbutylsulfonyl, 1,2-Di- methylbutylsulfonyl, 1,3-Dimethylbutylsulfonyl, 2,2-Dimethylbutylsulfonyl, 2,3-Dimethylbutylsulfonyl, 3,3-Dimethylbutylsulfonyl, 1-Ethylbutylsulfonyl, 2-Ethylbutylsulfonyl, 1,1,2-Trimethylpropylsulfonyl, 1,2,2-Trimethylpropylsulfonyl, 1-Ethyl-1-methylpropylsulfonyl und 1-Ethyl-2-methylpropylsulfonyl. Erfindungsgemäß steht "Heteroarylsulfonyl" für gegebenenfalls substituiertes Pyridylsulfonyl, Pyrimidinylsulfonyl, Pyrazinylsulfonyl oder gegebenenfalls substituiertes polycyclisches Heteroarylsulfonyl, hier insbesondere gegebenenfalls substituiertes Chinolinylsulfonyl, beispielsweise substituiert durch Fluor, Chlor, Brom, Iod, Cyano, Nitro, Alkyl-, Haloalkyl-, Haloalkoxy-, Amino-, Alkylamino-, Alkylcarbonylamino-, Dialkylamino- oder Alkoxygruppen. Erfindungsgemäß steht "Alkylthio" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes S-Alkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, wie (C1-C10)-, (C1-C6)- oder (C1-C4)-Alkylthio, z.B. (aber nicht beschränkt auf) (C1- C6)-Alkylthio wie Methylthio, Ethylthio, Propylthio, 1-Methylethylthio, Butylthio, 1-Methylpropylthio, 2-Methylpropylthio, 1,1-Dimethylethylthio, Pentylthio, 1-Methylbutylthio, 2-Methylbutylthio, 3- Methylbutylthio, 1,1-Dimethylpropylthio, 1,2-Dimethylpropylthio, 2,2-Dimethylpropylthio, 1- Ethylpropylthio, Hexylthio, 1-Methylpentylthio, 2-Methylpentylthio, 3-Methylpentylthio, 4-Methyl- pentylthio, 1,1-Dimethylbutylthio, 1,2-Dimethylbutylthio, 1,3-Dimethylbutylthio, 2,2-Dimethylbutyl- thio, 2,3-Dimethylbutylthio, 3,3-Dimethylbutylthio, 1-Ethylbutylthio, 2-Ethylbutylthio, 1,1,2-Tri- methylpropylthio, 1,2,2-Trimethylpropylthio, 1-Ethyl-1-methylpropylthio und 1-Ethyl-2-methyl- propylthio. „Alkenylthio“ bedeutet erfindungsgemäß ein über ein Schwefelatom gebundenen Alkenylrest, Alkinylthio bedeutet ein über ein Schwefelatom gebundenen Alkinylrest, Cycloalkylthio bedeutet ein über ein Schwefelatom gebundenen Cycloalkylrest und Cycloalkenylthio bedeutet ein über ein Schwefelatom gebundenen Cycloalkenylrest. „Alkylsulfinyl (Alkyl-S(=O)-)“, soweit nicht an anderer Stelle anders definiert steht erfindungsgemäß für Alkylreste, die über -S(=O)- an das Gerüst gebunden sind, wie (C1-C10)-, (C1-C6)- oder (C1-C4)- Alkylsulfinyl, z. B. (aber nicht beschränkt auf) (C1-C6)-Alkylsulfinyl wie Methylsulfinyl, Ethylsulfinyl, Propylsulfinyl, 1-Methylethylsulfinyl, Butylsulfinyl, 1-Methylpropylsulfinyl, 2-Methylpropylsulfinyl, 1,1-Dimethylethylsulfinyl, Pentylsulfinyl, 1-Methylbutylsulfinyl, 2-Methylbutylsulfinyl, 3- Methylbutylsulfinyl, 1,1-Dimethylpropylsulfinyl, 1,2-Dimethylpropylsulfinyl, 2,2-Di- methylpropylsulfinyl, 1-Ethylpropylsulfinyl, Hexylsulfinyl, 1-Methylpentylsulfinyl, 2-Methylpentyl- sulfinyl, 3-Methylpentylsulfinyl, 4-Methylpentylsulfinyl, 1,1-Dimethylbutylsulfinyl, 1,2-Dimethyl- butylsulfinyl, 1,3-Dimethylbutylsulfinyl, 2,2-Dimethylbutylsulfinyl, 2,3-Dimethylbutylsulfinyl, 3,3- Dimethylbutylsulfinyl, 1-Ethylbutylsulfinyl, 2-Ethylbutylsulfinyl, 1,1,2-Trimethylpropylsulfinyl, 1,2,2- Trimethylpropylsulfinyl, 1-Ethyl-1-methylpropylsulfinyl und 1-Ethyl-2-methylpropylsulfinyl. Analog sind „Alkenylsulfinyl“ und „Alkinylsulfinyl“, erfindungsgemäß definiert als Alkenyl- bzw. Alkinylreste, die über -S(=O)- an das Gerüst gebunden sind, wie (C2-C10)-, (C2-C6)- oder (C2-C4)- Alkenylsulfinyl bzw. (C3-C10)-, (C3-C6)- oder (C3-C4)-Alkinylsulfinyl. Analog sind „Alkenylsulfonyl“ und „Alkinylsulfonyl“ erfindungsgemäß definiert als Alkenyl- bzw. Alkinylreste, die über -S(=O)2- an das Gerüst gebunden sind, wie (C2-C10)-, (C2-C6)- oder (C2-C4)- Alkenylsulfonyl bzw. (C3-C10)-, (C3-C6)- oder (C3-C4)-Alkinylsulfonyl. „Alkoxy“ bedeutet ein über ein Sauerstoffatom gebundenen Alkylrest, z. B. (aber nicht beschränkt auf) (C1-C6)-Alkoxy wie Methoxy, Ethoxy, Propoxy, 1-Methylethoxy, Butoxy, 1-Methylpropoxy, 2- Methylpropoxy, 1,1-Dimethylethoxy, Pentoxy, 1-Methylbutoxy, 2-Methylbutoxy, 3-Methylbutoxy, 1,1- Dimethylpropoxy, 1,2-Dimethylpropoxy, 2,2-Dimethylpropoxy, 1-Ethylpropoxy, Hexoxy, 1- Methylpentoxy, 2-Methylpentoxy, 3-Methylpentoxy, 4-Methylpentoxy, 1,1-Dimethylbutoxy, 1,2-Di- methylbutoxy, 1,3-Dimethylbutoxy, 2,2-Dimethylbutoxy, 2,3-Dimethylbutoxy, 3,3-Dimethylbutoxy, 1- Ethylbutoxy, 2-Ethylbutoxy, 1,1,2-Trimethylpropoxy, 1,2,2-Trimethylpropoxy, 1-Ethyl-1-methyl- propoxy und 1-Ethyl-2-methylpropoxy. Alkenyloxy bedeutet ein über ein Sauerstoffatom gebundenen Alkenylrest, Alkinyloxy bedeutet ein über ein Sauerstoffatom gebundenen Alkinylrest wie (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkenoxy bzw. (C3-C10)-, (C3-C6)- oder (C3-C4)-Alkinoxy. „Cycloalkyloxy“ bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkylrest und Cycloalkenyloxy bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkenylrest. „Alkylcarbonyl“ (Alkyl-C(=O)-), soweit nicht an anderer Stelle anders definiert, steht erfindungsgemäß für Alkylreste, die über -C(=O)- an das Gerüst gebunden sind, wie (C1-C10)-, (C1-C6)- oder (C1-C4)- Alkylcarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkylrest in der Alkylcarbonylgruppe. Analog stehen „Alkenylcarbonyl“ und „Alkinylcarbonyl“, soweit nicht an anderer Stelle anders definiert, erfindungsgemäß für Alkenyl- bzw. Alkinylreste, die über -C(=O)- an das Gerüst gebunden sind, wie (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkenylcarbonyl bzw. (C2-C10)-, (C2-C6)- oder (C2-C4)- Alkinylcarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkenyl- bzw. Alkinylrest in der Alkenyl- bzw. Alkinylcarbonylgruppe. „Alkoxycarbonyl (Alkyl-O-C(=O)-)“, soweit nicht an anderer Stelle anders definiert: Alkylreste, die über -O-C(=O)- an das Gerüst gebunden sind, wie (C1-C10)-, (C1-C6)- oder (C1-C4)-Alkoxycarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkylrest in der Alkoxycarbonylgruppe. Analog stehen „Alkenyloxycarbonyl“ und „Alkinyloxycarbonyl“, soweit nicht an anderer Stelle anders definiert, erfindungsgemäß für Alkenyl- bzw. Alkinylreste, die über -O-C(=O)- an das Gerüst gebunden sind, wie (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkenyloxycarbonyl bzw. (C3-C10)-, (C3-C6)- oder (C3-C4)- Alkinyloxycarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkenyl- bzw. Alkinylrest in der Alken- bzw. Alkinyloxycarbonylgruppe. Der Begriff „Alkylcarbonyloxy“ (Alkyl-C(=O)-O-) steht erfindungsgemäß, soweit nicht an anderer Stelle anders definiert, für Alkylreste, die über eine Carbonyloxygruppe (-C(=O)-O-) mit dem Sauerstoff an das Gerüst gebunden sind, wie (C1-C10)-, (C1-C6)- oder (C1-C4)-Alkylcarbonyloxy. Die Anzahl der C- Atome bezieht sich dabei auf den Alkylrest in der Alkylcarbonyloxygruppe. Analog sind „Alkenylcarbonyloxy“ und „Alkinylcarbonyloxy“ erfindungsgemäß definiert als Alkenyl- bzw. Alkinylreste, die über (-C(=O)-O-) mit dem Sauerstoff an das Gerüst gebunden sind, wie (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkenylcarbonyloxy bzw. (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkinylcarbonyloxy. Die Anzahl der C-Atome bezieht sich dabei auf den Alkenyl- bzw. Alkinylrest in der Alkenyl- bzw. Alkinylcarbonyloxygruppe. In Kurzformen wie z.B. C(O)R12, C(O)OR12, OC(O)NR10R11, oder C(O)NR10R11 steht die in Klammern aufgeführte Kurzform O für ein über eine Doppelbindung an das benachbarte Kohlenstoffatom gebundenes Sauerstoffatom. In Kurzformen wie z.B. OC(S)OR12, OC(S)SR13, OC(S)NR10R11, steht die in Klammern aufgeführte Kurzform S für ein über eine Doppelbindung an das benachbarte Kohlenstoffatom gebundenes Schwefelatom. Der Begriff „Aryl“ bedeutet ein gegebenenfalls substituiertes mono-, bi- oder polycyclisches aromatisches System mit vorzugsweise 6 bis 14, insbesondere 6 bis 10 Ring-C-Atomen, beispielsweise Phenyl, Naphthyl, Anthryl, Phenanthrenyl, und ähnliches, vorzugsweise Phenyl. Vom Begriff „gegebenenfalls substituiertes Aryl“ sind auch mehrcyclische Systeme, wie Tetrahydronaphtyl, Indenyl, Indanyl, Fluorenyl, Biphenylyl, umfasst, wobei die Bindungsstelle am aromatischen System ist. Von der Systematik her ist „Aryl“ in der Regel auch von dem Begriff „gegebenenfalls substituiertes Phenyl“ umfasst. Bevorzugte Aryl-Substituenten sind hier zum Beispiel Wasserstoff, Halogen, Alkyl, Cycloalkyl, Cycloalkylalkyl, Cycloalkenyl, Halocycloalkyl, Alkenyl, Alkinyl, Aryl, Arylalkyl, Arylalkenyl, Heteroaryl, Heteroarylalkyl, Heterocyclyl, Heterocyclylalkyl, Alkoxyalkyl, Alkylthio, Haloalkylthio, Haloalkyl, Alkoxy, Haloalkoxy, Cycloalkoxy, Cycloalkylalkoxy, Aryloxy, Heteroraryloxy, Alkoxyalkoxy, Alkinylalkoxy, Alkenyloxy, Bis-alkylaminoalkoxy, Tris- [alkyl]silyl, Bis-[alkyl]arylsilyl, Bis-[alkyl]alkylsilyl, Tris-[alkyl]silylalkinyl, Arylalkinyl, Heteroarylalkinyl, Alkylalkinyl, Cycloalkylalkinyl, Haloalkylalkinyl, Heterocyclyl-N-alkoxy, Nitro, Cyano, Amino, Alkylamino, Bis-alkylamino, Alkylcarbonylamino, Cycloalkylcarbonylamino, Arylcarbonylamino, Alkoxycarbonylamino, Alkoxycarbonylalkylamino, Arylalkoxycarbonylalkylamino, Hydroxycarbonyl, Alkoxycarbonyl, Aminocarbonyl, Alkylaminocarbonyl, Cycloalkylaminocarbonyl, Bis-Alkylaminocarbonyl, Heteroarylalkoxy, Arylalkoxy Ein heterocyclischer Rest (Heterocyclyl) enthält mindestens einen heterocyclischen Ring (=carbocyclischer Ring, in dem mindestens ein C-Atom durch ein Heteroatom ersetzt ist, vorzugsweise durch ein Heteroatom aus der Gruppe N, O, S, P) der gesättigt, ungesättigt, teilgesättigt oder heteroaromatisch ist und dabei unsubstituiert oder substituiert sein kann, wobei die Bindungsstelle an einem Ringatom lokalisiert ist. Ist der Heterocyclylrest oder der heterocyclische Ring gegebenenfalls substituiert, kann er mit anderen carbocyclischen oder heterocyclischen Ringen annelliert sein. Im Falle von gegebenenfalls substituiertem Heterocyclyl werden auch mehrcyclische Systeme umfasst, wie beispielsweise 8-Aza-bicyclo[3.2.1]octanyl, 8-Aza-bicyclo[2.2.2]octanyl oder 1-Aza- bicyclo[2.2.1]heptyl. Im Falle von gegebenenfalls substituiertem Heterocyclyl werden auch spirocyclische Systeme umfasst, wie beispielsweise 1-Oxa-5-aza-spiro[2.3]hexyl. Wenn nicht anders definiert, enthält der heterocyclische Ring vorzugsweise 3 bis 9 Ringatome, insbesondere 3 bis 6 Ringatome, und ein oder mehrere, vorzugsweise 1 bis 4, insbesondere 1, 2 oder 3 Heteroatome im heterocyclischen Ring, vorzugsweise aus der Gruppe N, O, und S, wobei jedoch nicht zwei Sauerstoffatome direkt benachbart sein sollen, wie beispielsweise mit einem Heteroatom aus der Gruppe N, O und S 1- oder 2- oder 3-Pyrrolidinyl, 3,4-Dihydro-2H-pyrrol-2- oder 3-yl, 2,3-Dihydro-1H-pyrrol- 1- oder 2- oder 3- oder 4- oder 5-yl; 2,5-Dihydro-1H-pyrrol-1- oder 2- oder 3-yl, 1- oder 2- oder 3- oder 4-Piperidinyl; 2,3,4,5-Tetrahydropyridin-2- oder 3- oder 4- oder 5-yl oder 6-yl; 1,2,3,6- Tetrahydropyridin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2,3,4-Tetrahydropyridin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,4-Dihydropyridin-1- oder 2- oder 3- oder 4-yl; 2,3-Dihydropyridin- 2- oder 3- oder 4- oder 5- oder 6-yl; 2,5-Dihydropyridin-2- oder 3- oder 4- oder 5- oder 6-yl, 1- oder 2- oder 3- oder 4-Azepanyl; 2,3,4,5-Tetrahydro-1H-azepin-1- oder 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-1H-azepin-1- oder 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7- Tetrahydro-1H-azepin-1- oder 2- oder 3- oder 4-yl; 3,4,5,6-Tetrahydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-1H-azepin-1- oder 2- oder 3- oder 4-yl; 2,5-Dihydro-1H-azepin- 1- oder -2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-1H-azepin-1- oder -2- oder 3- oder 4- yl; 2,3-Dihydro-1H-azepin-1- oder -2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3,4-Dihydro-2H-azepin- 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3,6-Dihydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 5,6-Dihydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-3H-azepin- 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 1H-Azepin-1- oder -2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl, 2- oder 3-Oxolanyl (= 2- oder 3- Tetrahydrofuranyl); 2,3-Dihydrofuran-2- oder 3- oder 4- oder 5-yl; 2,5-Dihydrofuran-2- oder 3-yl, 2- oder 3- oder 4-Oxanyl (= 2- oder 3- oder 4-Tetrahydropyranyl); 3,4-Dihydro-2H-pyran-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-pyran-2- oder 3-oder 4- oder 5- oder 6-yl; 2H-Pyran-2- oder 3- oder 4- oder 5- oder 6-yl; 4H-Pyran-2- oder 3- oder 4-yl, 2- oder 3- oder 4-Oxepanyl; 2,3,4,5- Tetrahydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydrooxepin-2- oder 3- oder 4-yl; 2,3-Dihydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydrooxepin-2- oder 3- oder 4-yl; 2,5-Dihydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; Oxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2- oder 3- Tetrahydrothiophenyl; 2,3-Dihydrothiophen-2- oder 3- oder 4- oder 5-yl; 2,5-Dihydrothiophen-2- oder 3-yl; Tetrahydro-2H-thiopyran-2- oder 3- oder 4-yl; 3,4-Dihydro-2H-thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 2H-Thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 4H-Thiopyran-2- oder 3- oder 4-yl. Bevorzugte 3-Ring und 4-Ring- Heterocyclen sind beispielsweise 1- oder 2-Aziridinyl, Oxiranyl, Thiiranyl, 1- oder 2- oder 3-Azetidinyl, 2- oder 3-Oxetanyl, 2- oder 3-Thietanyl, 1,3-Dioxetan-2-yl. Weitere Beispiele für “Heterocyclyl“ sind ein partiell oder vollständig hydrierter heterocyclischer Rest mit zwei Heteroatomen aus der Gruppe N, O und S, wie beispielsweise 1- oder 2- oder 3- oder 4-Pyrazolidinyl; 4,5-Dihydro-3H-pyrazol- 3- oder 4- oder 5-yl; 4,5-Dihydro-1H-pyrazol-1- oder 3- oder 4- oder 5-yl; 2,3-Dihydro-1H-pyrazol-1- oder 2- oder 3- oder 4- oder 5-yl; 1- oder 2- oder 3- oder 4- Imidazolidinyl; 2,3-Dihydro-1H-imidazol-1- oder 2- oder 3- oder 4-yl; 2,5-Dihydro-1H-imidazol-1- oder 2- oder 4- oder 5-yl; 4,5-Dihydro-1H-imidazol-1- oder 2- oder 4- oder 5-yl; Hexahydropyridazin-1- oder 2- oder 3- oder 4-yl; 1,2,3,4-Tetrahydropyridazin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2,3,6-Tetrahydropyridazin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,4,5,6-Tetrahydropyridazin-1- oder 3- oder 4- oder 5- oder 6-yl; 3,4,5,6-Tetrahydropyridazin-3- oder 4- oder 5-yl; 4,5-Dihydropyridazin-3- oder 4-yl; 3,4-Dihydropyridazin-3- oder 4- oder 5- oder 6-yl; 3,6-Dihydropyridazin-3- oder 4-yl; 1,6-Dihydropyriazin-1- oder 3- oder 4- oder 5- oder 6-yl; Hexahydropyrimidin-1- oder 2- oder 3- oder 4-yl; 1,4,5,6-Tetrahydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 1,2,5,6-Tetrahydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 1,2,3,4- Tetrahydropyrimidin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,6-Dihydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 1,2-Dihydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 2,5-Dihydropyrimidin- 2- oder 4- oder 5-yl; 4,5-Dihydropyrimidin- 4- oder 5- oder 6-yl; 1,4-Dihydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 1- oder 2- oder 3-Piperazinyl; 1,2,3,6-Tetrahydropyrazin-1- oder 2- oder 3- oder 5- oder 6-yl; 1,2,3,4-Tetrahydropyrazin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2-Dihydropyrazin-1- oder 2- oder 3- oder 5- oder 6-yl; 1,4-Dihydropyrazin-1- oder 2- oder 3-yl; 2,3-Dihydropyrazin-2- oder 3- oder 5- oder 6-yl; 2,5-Dihydropyrazin-2- oder 3-yl; 1,3-Dioxolan-2- oder 4- oder 5-yl; 1,3-Dioxol-2- oder 4-yl; 1,3-Dioxan-2- oder 4- oder 5-yl; 4H-1,3-Dioxin-2- oder 4- oder 5- oder 6-yl; 1,4-Dioxan-2- oder 3- oder 5- oder 6-yl; 2,3-Dihydro-1,4-dioxin-2- oder 3- oder 5- oder 6-yl; 1,4-Dioxin-2- oder 3-yl; 1,2-Dithiolan-3- oder 4-yl; 3H-1,2-Dithiol-3- oder 4- oder 5-yl; 1,3-Dithiolan-2- oder 4-yl; 1,3-Dithiol- 2- oder 4-yl; 1,2-Dithian-3- oder 4-yl; 3,4-Dihydro-1,2-dithiin-3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro- 1,2-dithiin-3- oder 4-yl; 1,2-Dithiin-3- oder 4-yl; 1,3-Dithian-2- oder 4- oder 5-yl; 4H-1,3-Dithiin-2- oder 4- oder 5- oder 6-yl; Isoxazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydroisoxazol-2- oder 3- oder 4- oder 5-yl; 2,5-Dihydroisoxazol-2- oder 3- oder 4- oder 5-yl; 4,5-Dihydroisoxazol-3- oder 4- oder 5-yl; 1,3-Oxazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydro-1,3-oxazol-2- oder 3- oder 4- oder 5-yl; 2,5- Dihydro-1,3-oxazol-2- oder 4- oder 5-yl; 4,5-Dihydro-1,3-oxazol-2- oder 4- oder 5-yl; 1,2-Oxazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-1,2-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6- Dihydro-2H-1,2-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H-1,2-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-1,2-oxazin-3- oder 4- oder 5- oder 6-yl; 2H-1,2-Oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 6H-1,2-Oxazin-3- oder 4- oder 5- oder 6-yl; 4H-1,2-Oxazin-3- oder 4- oder 5- oder 6-yl; 1,3-Oxazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-1,3-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-1,3-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H- 1,3-oxazin-2- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-1,3-oxazin-2- oder 4- oder 5- oder 6-yl; 2H- 1,3-Oxazin-2- oder 4- oder 5- oder 6-yl; 6H-1,3-Oxazin-2- oder 4- oder 5- oder 6-yl; 4H-1,3-Oxazin-2- oder 4- oder 5- oder 6-yl; Morpholin-2- oder 3- oder 4-yl; 3,4-Dihydro-2H-1,4-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-1,4-oxazin-2- oder 3- oder 5- oder 6-yl; 2H-1,4-oxazin-2- oder 3- oder 5- oder 6-yl; 4H-1,4-oxazin-2- oder 3-yl; 1,2-Oxazepan-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 2,3,4,5-Tetrahydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-1,2- oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,5,6,7-Tetrahydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 4,5,6,7-Tetrahydro-1,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,5-Dihydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-1,2- oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 4,7-Dihydro-1,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-1,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 1,2-Oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 1,3-Oxazepan-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,5-Tetrahydro-1,3- oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-1,3-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-1,3-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 2,5,6,7-Tetrahydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 4,5,6,7-Tetrahydro-1,3- oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-1,3-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,5-Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-1,3-oxazepin- 2- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 4,7- Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 1,3-Oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 1,4-Oxazepan-2- oder 3- oder 5- oder 6- oder 7-yl; 2,3,4,5-Tetrahydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7- Tetrahydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-1,4-oxazepin- 2- oder 3- oder 5- oder 6- oder 7-yl; 2,5,6,7-Tetrahydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7- yl; 4,5,6,7-Tetrahydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-1,4- oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 2,5-Dihydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,7-Dihydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 6,7-Dihydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 1,4-Oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; Isothiazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydroisothiazol-2- oder 3- oder 4- oder 5- yl; 2,5-Dihydroisothiazol-2- oder 3- oder 4- oder 5-yl; 4,5-Dihydroisothiazol-3- oder 4- oder 5-yl; 1,3- Thiazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydro-1,3-thiazol-2- oder 3- oder 4- oder 5-yl; 2,5- Dihydro-1,3-thiazol-2- oder 4- oder 5-yl; 4,5-Dihydro-1,3-thiazol-2- oder 4- oder 5-yl; 1,3-Thiazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-1,3-thiazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6- Dihydro-2H-1,3-thiazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H-1,3-thiazin-2- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-1,3-thiazin-2- oder 4- oder 5- oder 6-yl; 2H-1,3-Thiazin-2- oder 4- oder 5- oder 6-yl; 6H-1,3-Thiazin-2- oder 4- oder 5- oder 6-yl; 4H-1,3-Thiazin-2- oder 4- oder 5- oder 6-yl. Weitere Beispiele für “Heterocyclyl“ sind ein partiell oder vollständig hydrierter heterocyclischer Rest mit 3 Heteroatomen aus der Gruppe N, O und S, wie beispielsweise 1,4,2-Dioxazolidin-2- oder 3- oder 5-yl; 1,4,2-Dioxazol-3- oder 5-yl; 1,4,2-Dioxazinan-2- oder -3- oder 5- oder 6-yl; 5,6-Dihydro-1,4,2- dioxazin-3- oder 5- oder 6-yl; 1,4,2-Dioxazin-3- oder 5- oder 6-yl; 1,4,2-Dioxazepan-2- oder 3- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-5H-1,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-7H-1,4,2- Dioxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-5H-1,4,2-Dioxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 5H-1,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl; 7H-1,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl. Strukturbeispiele für gegebenenfalls weiter substituierte Heterocyclen sind auch im Folgenden aufgeführt: C
Figure imgf000088_0001
'
Figure imgf000018_0001
R8th, R9, R10, R15, R18, R19, R20 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, S(O)mR33, R32(O=)C-(C1-C6)-alkyl, C(O=)R32, (C1-C6)-alkyloxycarbonyl, aryl-(C1-C6)-alkyloxycarbonyl, R8th and R9 with the nitrogen atoms to which they are attached form a fully saturated or partially saturated 5 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R11, R12, R13, R14 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)- alkynyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, OR32 stand, r16, R17, R21, R22 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)- alkynyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stand, r23, R24 independently for hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, C(O=)R32, (C1-C6)-alkyloxycarbonyl, aryl-(C1-C6)-alkyloxycarbonyl, R25, R28, R29 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-alkyl, R26, R27 independently for hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)- alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R30 and R31 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-haloalkoxy-(C1-C6)-alkyl, (C1-C6)-alkylthio-(C1-C6)-alkyl, (C1-C6)-haloalkylthio-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C6)-cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, heterocyclyl, (C1-C6)-alkoxycarbonyl, bis[(C1- C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1- C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-alkenyloxycarbonyl, (C2-C6)-alkynyloxycarbonyl, heterocyclyl-(C1-C6)-alkyl, (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkynyloxycarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, or R30 and R31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R32 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-haloalkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, aryl, aryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C6)-cycloalkenyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-alkyl-amino-(C2-C6)-alkyl, aryl-(C1-C6)-alkylamino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, hydroxycarbonyl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, tris-[(C1-C6)-alkyl]silyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-alkyl]-bis(aryl)silyl-(C1-C6)-alkyl, (C1-C6)-alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-cycloalkylcarbonyloxy-(C1-C6)-alkyl, arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, aryloxy-(C1-C6)-alkyl, heteroaryloxy-(C1-C6)-alkyl, heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkynyloxycarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, R33 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C10)-cycloalkyl, (C3-C10)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C10)-cycloalkenyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]amino, (C1-C6)-alkyl-amino, aryl-(C1-C6)-amino, aryl-(C1- C6)-alkyl-amino, aryl-[(C1-C6)-alkyl]amino; heteroaryl-(C1-C6)-amino, heteroaryl-(C1-C6)-alkyl-amino, heteroaryl-[(C1-C6)-alkyl]amino; heterocyclyl-(C1-C6)-amino, heterocyclyl-(C1- C6)-alkyl-amino, heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-cycloalkyl-amino, (C3-C6)-cycloalkyl-[(C1-C6)-alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R34 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, NO30R31, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, S(O)mR33 stands, R35 for hydrogen, NO30R31, OR32, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, S(O)mR33, R32(O=)C-(C1-C6)-alkyl, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, R33SO)m- (C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, R36 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, (C3-C10)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-alkyl, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, R33S(O)m-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, R37 for (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C2-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, heteroaryloxy-(C1-C6)-alkyl, aryloxy-(C1-C6)-alkyl, heterocyclyloxy-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-alkyl and R38 for (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, aryl, aryl-(C1-C8th)-alkyl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, heterocyclyl, heterocyclyl-(C1-C8th)-alkyl, (C3-C10)-cycloalkyl, (C3-C10)-cycloalkyl-(C1-C8th)-alkyl, R32(O=)C-(C1-C8th)-alkyl, R32O(O)C-(C1-C8th)-alkyl, R30R31N(O)C-(C1-C8th)-alkyl, R33S(O)m-(C1-C8th)-alkyl, R32O-(C1-C8th)-alkyl, R30R31N-(C1-C8th)- alkyl. A very particularly preferred subject of the invention is the use of compounds of the general formula (I) in which R1 for hydrogen, NO30R31, OR32, S(O)mR33, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C2-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, (C3-C10)- cycloalkyl-(C1-C6)-alkyl, R33SO)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-alkyl, C(=O)R32, C(=O)OR32 stands, m stands for 0, 1, 2, R3 and R4 independently hydrogen, methyl, ethyl, prop-1-yl, 1-methyleth-1-yl, vinyl, 1-methyleth-1-en-1-yl, prop-2-en-1-yl, difluoromethyl, trifluoromethyl , cyclopropyl, cyclobutyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, phenyl, benzyl, methoxymethyl, ethoxymethyl, methoxyethyl, ethoxyethyl, R5, R6 independently hydrogen, methyl, ethyl, prop-1-yl, 1-methyleth-1-yl, vinyl, prop-2-en-1-yl, difluoromethyl, trifluoromethyl, cyclopropyl, cyclobutyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl , Phenyl, 4-Fluorophenyl, 3-Fluorophenyl, 2-Fluorophenyl, 4-Chlorophenyl, 3-Chlorophenyl, 2-Chlorophenyl, Benzyl, 4-Fluorobenzyl, 3-Fluorobenzyl, 2-Fluorobenzyl, Pyridin-2-ylmethyl, Pyridin-3 -ylmethyl, pyridin-4-ylmethyl, methoxymethyl, ethoxymethyl, methoxyethyl, ethoxyethyl, heterocyclyl, hydroxy, methoxy, ethoxy, methylcarbonyloxy, ethylcarbonyloxy, 1-methyleth-1-ylcarbonyloxy, 1,1-dimethyleth-1-ylcarbonyloxy, R3 and R5 with the carbon atoms to which they are attached form a fully saturated or partially saturated 5 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R2 stands for hydrogen and one of the following groups G-1 to G-2, where an arrow stands for a bond to the pyrrolidinone ring in the general formula (I), R7 represents hydrogen and one of the following groups G-1 to G-15, where an arrow represents a bond to the pyrrolidinone ring in general formula (I), with the proviso that R2 and R7 are not simultaneously H and that R7 stands for H if R2 stands for one of the following groups G-1 to G-2, and that R2 stands for H if R7 stands for one of the following groups G-1 to G-15, '
Figure imgf000023_0001
R8th, R9, R10, R15, R18, R19, R20 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, S(O)mR33, R32(O=)C-(C1-C6)-alkyl, C(O=)R32, (C1-C6)-alkyloxycarbonyl, aryl-(C1-C6)-alkyloxycarbonyl, R8th and R9 with the nitrogen atoms to which they are attached form a fully saturated or partially saturated 5 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R11, R12, R13, R14 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)- alkynyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, OR32 stand, r16, R17, R21, R22 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)- alkynyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stand, r23, R24 independently for hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, C(O=)R32, (C1-C6)-alkyloxycarbonyl, aryl-(C1-C6)-alkyloxycarbonyl, R25, R28, R29 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-alkyl, R26, R27 independently for hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)- alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R30 and R31 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-haloalkoxy-(C1-C6)-alkyl, (C1-C6)-alkylthio-(C1-C6)-alkyl, (C1-C6)-haloalkylthio-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C6)-cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, heterocyclyl, (C1-C6)-alkoxycarbonyl, bis[(C1- C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1- C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-alkenyloxycarbonyl, (C2-C6)-alkynyloxycarbonyl, heterocyclyl-(C1-C6)-alkyl, (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkynyloxycarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, or R30 and R31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R32 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-haloalkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, aryl, aryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C6)-cycloalkenyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-alkyl-amino-(C2-C6)-alkyl, aryl-(C1-C6)-alkylamino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, hydroxycarbonyl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, tris-[(C1-C6)-alkyl]silyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-alkyl]-bis(aryl)silyl-(C1-C6)-alkyl, (C1-C6)-alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-cycloalkylcarbonyloxy-(C1-C6)-alkyl, arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, aryloxy-(C1-C6)-alkyl, heteroaryloxy-(C1-C6)-alkyl, heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkynyloxycarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, R33 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C10)-cycloalkyl, (C3-C10)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C10)-cycloalkenyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]amino, (C1-C6)-alkyl-amino, aryl-(C1-C6)-amino, aryl-(C1- C6)-alkyl-amino, aryl-[(C1-C6)-alkyl]amino; heteroaryl-(C1-C6)-amino, heteroaryl-(C1-C6)-alkyl-amino, heteroaryl-[(C1-C6)-alkyl]amino; heterocyclyl-(C1-C6)-amino, heterocyclyl-(C1- C6)-alkyl-amino, heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-cycloalkyl-amino, (C3-C6)-cycloalkyl-[(C1-C6)-alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R34 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, NO30R31, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, S(O)mR33 stands, R35 for hydrogen, NO30R31, OR32, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, S(O)mR33, R32(O=)C-(C1-C6)-alkyl, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, R33SO)m- (C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, R36 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, (C3-C10)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-alkyl, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, R33S(O)m-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, R37 for (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C2-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, heteroaryloxy-(C1-C6)-alkyl, aryloxy-(C1-C6)-alkyl, heterocyclyloxy-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-alkyl and R38 for (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, aryl, aryl-(C1-C8th)-alkyl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, heterocyclyl, heterocyclyl-(C1-C8th)-alkyl, (C3-C10)-cycloalkyl, (C3-C10)-cycloalkyl-(C1-C8th)-alkyl, R32(O=)C-(C1-C8th)-alkyl, R32O(O)C-(C1-C8th)-alkyl, R30R31N(O)C-(C1-C8th)-alkyl, R33S(O)m-(C1-C8th)-alkyl, R32O-(C1-C8th)-alkyl, R30R31N-(C1-C8th)- alkyl. A particularly preferred subject of the invention is the use of the following compounds described by general formula (I): 2-[1-[(3-chloro-2-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[ 1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamide, 2-[1- [(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1 -methyl-1H-tetrazol-5-yl)acetamide, (2S,3S)-2-[[2-[(2S)-1-[(2,3- difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-methylpentanoic acid, methyl 5-[[2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl ]acetyl]amino]-4-oxopentanoate, 2-(4-fluorophenoxy)ethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, methyl 2-[1- [(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-methylsulfonylethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-methylsulfanylethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, (2S,3S)-2-[[2-[(2R)-1-[( 2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-methylpentanecarboxylic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl] -N-methylsulfonylacetamide, 1-[2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]pyrrolidine-2-carboxylic acid, 2-[(2R)-1-[ (2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-methoxyethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, ( 2R,3R)-2-[[2-[(2R)-1-[(2,3-difluorophenyl)methyl]-5-oxop yrrolidin-2-yl]acetyl]amino]-3-methylpentanecarboxylic acid, cyclopentyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2,2-dimethylpropyl 2-[ 1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, ethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, cyclopropylmethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, allyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2- yl] acetate, 2-[1-[(3-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-phenylsulfanylethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidine -2-yl]acetate, prop-2-yn-1-yl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, cyclobutyl 2-[1-[( 2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, isopropyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, but-3- en-1-yl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-phenoxyethyl 2-[1-[(2,3-difluorophenyl)methyl]- 5-oxopyrrolidin-2-yl]acetate, Pentan-2-yl 2-[1-[(2,3-difluorophenyl)methyl] -5-oxopyrrolidin-2-yl]acetate, 2-(4-chlorophenyl)sulfinylethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, butan-2-yl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-(4-Methoxyphenoxy)ethyl 2-[1-[(2,3-difluorophenyl)methyl]- 5-oxopyrrolidin-2-yl]acetate, 2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-(benzylsulfonyl)ethyl 2-[1-[(2 ,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-(4-chlorophenoxy)ethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl] acetate, 2-(4-methylphenoxy)ethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1-[(2,3-difluoro-4 - methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 3-methylbutan-2-yl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, methyl (2S)-2-[[2-[(2R)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(1H-imidazole-4- yl)propionate, 2-[(4-chlorophenyl)thio]ethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[(2S)-1- [(3.4 - difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-phenylsulfanylethyl 2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-(4- chlorophenyl)sulfinylethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[(2R)-1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidine -2-yl]acetic acid, 2-[1-[(3-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, (2R)-2-[[2-[(2R)-1-[( 2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, 2-[(4-methoxyphenyl)thio]ethyl 2-[1-[(2,3-difluorophenyl) methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[(4- methylphenyl)thio]ethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, methyl 2-[1-[(3-chloro-2-fluorophenyl)methyl]- 5-oxopyrrolidin-2-yl]acetate, (2R,3R)-2-[[2-[(2S)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl] amino]-3-methylpentanoic acid, 2-(4-fluorophenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, (2R)-2-[[2-[ 1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, 4-[2-[2-[1-[(4-methylphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetyl]oxyethoxy]benzoic acid, (2R)-2-[[2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino] -4-methylpentanecarboxylic acid, 2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-methylsulfonylacetamide, 2-[1-[(2,3-difluorophenyl )methyl]-5-oxopyrrolidin-2-yl]-N-(4-methyl-1,2,5-oxadiazol-3-yl)acetamide, 2-(4-chlorophenoxy)ethyl 2-[1-[(4 -methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-(4-methylphenyl)sulfinylethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrro lidin-2-yl]acetate, 2-[1-[(2,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-phenylsulfanylethyl 2-[1-[(3-fluorophenyl)methyl] -5-oxopyrrolidin-2-yl]acetate, methyl 2-[1-[(3-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1-[(3,5-difluorophenyl)methyl ]-5-oxopyrrolidin-2-yl]acetic acid, methyl 1-[[2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]cyclopropanecarboxylate, 2-( 2,4-dichlorophenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1-[(4-fluorophenyl)methyl]-5-oxopyrrolidin-2 -yl]acetic acid, ethyl 2-(1-benzyl-5-oxopyrrolidin-2-yl)acetate, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (2-hydroxyethyl)acetamide, methyl 2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, (2S)-2-[[2-[(2R)-1 -[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentanecarboxylic acid, methyl (2S)-2-[[2-[(2S)-1-[(2,3 - difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(1H-imidazol-4-yl)propionate, 2-[1-[(2-fluorophe nyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-(1-benzyl-5-oxopyrrolidin-2-yl)acetic acid, 2-[1-[(3-fluorophenyl)methyl]-5-oxopyrrolidin- 2-yl]acetamide, (2S)-2-[[2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, 2-[ 1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(trifluoromethylsulfonyl)acetamide, 2-[1-[(3-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl ]-N-methyl-N-methylsulfonylacetamide, methyl 2-[[2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]methylamino]acetate, 2-(4 -methoxyphenyl)sulfonylethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetic acid, methyl 5-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-oxopentanoate, methyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, N -benzyl-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, (2S)-4 -methyl-2-[[2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino] pentanoic acid, N-[2-(3-methylphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2,3- difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-methylpropyl)acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2 -[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N',N'-dimethylacetohydrazide, N-(2-hydroxyethyl)-2-[1-[(4-methylphenyl )methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-(4-formylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetate, N-allyl-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-[(1-ethyl-3-methyl- 1H-pyrazol-4-yl)methyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-(4-methoxyphenyl)sulfinylethyl 2-[1-[( 2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, (2R,3R)-2-[[2-[(2S)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidine -2-yl]acetyl]amino]-3-methylpentanecarboxylic acid, N-methyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, 2-[1- [(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-phenylethyl)acetamide, 2-(2,4-dimethylphenoxy)ethyl 2-[1-[(4-methylphenyl) methyl]-5-oxopyrrolidin-2-yl]acetate, N-[(6-chloropyridin-3-yl)methyl]-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2- yl]-N-methylacetamide, (2R)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylsulfanylbutyric acid, methyl 3-[ [2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]butyrate, 2-[1-[(4-methylphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-(2-methylpropyl)acetamide, methyl 3-[[2-[1-[(3-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionate , 2-[1-[(3-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(trifluoromethylsulfonyl)acetamide, methyl 3-[[2-[1-[(4-methylphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetyl]amino]butyrate, [(1S,2R,5R)-2-isopropyl-5-methylcyclohexyl] 2-[(2R)-1-[(2,3-difluorophenyl)methyl] -5-oxopyrrolidin-2-yl]acetate, 2-[(2S)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-prop-2-yn-1-ylacetamide, 2-(4-bromophenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetate, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl) acetamide, [(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl] 2-[(2R)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2 -[5-oxo-3-phenyl-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]acetic acid, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]- N Propy lacetamide, (2S)-2-[[2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(1H-indol-3-yl) propionic acid, (2R)-2-[[2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(1H-indol-3-yl) propionic acid, 2-[1-[(3-chloro-2-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, 2-[5-oxo-1-[(3,4,5- trifluorophenyl)methyl]pyrrolidin-2-yl]acetic acid, 2-(4-ethylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-phenoxyethyl 2-[ 1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 1-[(2,3-difluorophenyl)methyl]-5-(2-oxo-2-pyrrolidin-1-ylethyl)pyrrolidine -2-one, 2-(4-methylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1-[(2,3-difluorophenyl) methyl]-5-oxopyrrolidin-2-yl]-N-ethylsulfonylacetamide, (2S)-2-[[2-[(2S)-1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl] acetyl]amino]-4-methylpentanecarboxylic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N,N-diethylacetamide, 2-[1-[(3-chlorophenyl )methyl] -5-oxopyrrolidin-2-yl]-N-(difluoromethylsulfonyl)acetamide, Ethyl-(2R)-1-[2-[(2S)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]piperidine-2-carboxylate, 2-[3-(trifluoromethyl)phenoxy]ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-(4- tert-butylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, N-(difluoromethylsulfonyl)-2-[1-[(2,3-difluorophenyl)methyl] -5-oxopyrrolidin-2-yl]acetamide, 2- methoxyethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[(4-chlorophenyl)thio]ethyl 2-[1-[(4-methylphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetate, 2-[(2R)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1, 2,4-triazol-5-yl)acetamide, 2-[1-[(4-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl ]-5-oxopyrrolidin-2-yl]-N-isopropylsulfonylacetamide, 2-[1-[(2,3-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, (2R,3R)- 2-[ [2-[(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-methylpentanoic acid, 2-[1-[(2,3-difluorophenyl)methyl ]-5-oxopyrrolidin-2-yl]-N-(pyridin-2-ylmethyl)acetamide, 2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2- [1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(quinolin-5-ylmethyl)acetamide, 2,2-dimethylpropyl 2-[1-[(4-methylphenyl) methyl]-5-oxopyrrolidin-2-yl]acetate, 2-(2-chlorophenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-methyl sulfanylethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-oxopyrrolidin- 2-yl]acetic acid, ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-(2-chlorophenyl)sulfonylethyl 2-[1-[(4-methylphenyl) methyl]-5-oxopyrrolidin-2-yl]acetate, methyl 2-[[2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]benzoate, 2- (2,4-dichlorophenyl)sulfonylethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, N -[2-(3,4-dichlorophenyl)ethyl]-2-[ 1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, prop-2-yn-1-yl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin- 2-yl]acetate, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2,2,2-trifluoroethylsulfonyl)acetamide, N-benzyl-2- [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-( dimethylsulfamoyl)acetamide, methyl 3-[[2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino ]propionate, 2-phenylsulfanylethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, N -[2-(1,3-benzodioxol-5-yl)ethyl]-2 -[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[1-(4-fluorophenyl)cyclopropyl]-5-oxopyrrolidin-2-yl]acetic acid, 2 -[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1-ethyl-1H-pyrazol-3-yl)methyl]acetamide, but-3-en- 1-yl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, methyl (2S)-3-(1H-imidazol-4-yl)-2-[[2- [(2S)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-,yl]acetyl]amino]propionate, 2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2 -yl]acetic acid, N-(difluoromethylsulfonyl)-2-[1-[(3-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, methyl 4-[2-[2-[1-[(4 -methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]oxyethoxy]benzoate, N-cyclopropylsulfonyl-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2,3-difluoro-4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, 2-[1-[(2,3-dichlorophenyl) methyl]-5-oxopyrrolidin-2-yl]-N-(trifluoromethylsulfonyl)acetamide, 2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamide , 2-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(3-chlorophenyl)methyl]-5-oxopyrrolidin-2 -yl]-N-methylsulfonylacetamide, N-cyclopropyl-2-[1-[(3-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(4-ethylphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, (2S)-2-[[2-[(2S)-1-[(2-ethylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentanecarboxylic acid, cyclopropylmethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1-[(4-chlorophenyl )methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, tert-butyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1 -[[3-(difluoromethoxy)phenyl]methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(3-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, 2-[4-(acetylamino)phenoxy]ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, N -[2-(4-tert-butylphenyl)ethyl]- 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N -(2,2,2-trifluoroethyl)acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-methoxyethyl)acetamide, 2-[1 -[2-(4-fluorophenyl)propan-2-yl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl] -N-prop-2-yn-1-ylacetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidine -2-yl]-N-[(2-ethylphenyl)methyl]acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1-ethyl -3-methyl-1H-pyrazol-4-yl)methyl]acetamide, N-[(6-chloropyridin-3-yl)methyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidine- 2-yl]acetamide, 2-[1-[(2,3-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(difluoromethylsulfonyl)acetamide, isopropyl 2-[1-[(4-methylphenyl) methyl]-5-oxopyrrolidin-2-yl]acetate, cyclobutyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1-[[4-(difluoromethoxy) phenyl]methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(3-methylbutyl)acetamide, N -[2-(2-bromophenyl)ethyl]-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2,3-difluorophenyl )methyl]-5-oxopyrrolidin-2-yl]-N-ethylacetamide, (2R)-4-methyl-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl ]acetyl]amino]pentanoic acid, 2-[5-oxo-1-[[3-(trifluoromethyl)phenyl]methyl]pyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl) methyl]-5-oxopyrrolidin-2-yl]-N-[2-(3,5-dimethoxyphenyl)ethyl]acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2- yl]-N-methyl-N-phenylacetamide, N-isopropyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, sodium;[2-[1-[(2 ,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]methylsulfonylazanide, N -[(6-chloropyridin-3-yl)methyl]-2-[1-[(2,3-difluorophenyl)methyl ]-5-oxopyrrolidin-2-yl]acetamide, methyl 3-[[2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionate, N-[ 2-(2,4-difluorophenyl)ethyl]-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, cyclopentyl 2-[1-[(4-methylphenyl) methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-2-yl]acetic acid, 2-[1-[(2,3- difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylacetamide, allyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1-[( 2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(trifluoromethylsulfonyl)acetamide, 2-[1-[(2,3-dichlorophenyl)methy 1]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, methyl 2-[methyl-[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]acetate , 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1R,2S)-2,6-dimethylindan-1-yl]acetamide, 2-[ 1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, 2-[5-oxo-1-[[3-(trifluoromethoxy)phenyl]methyl]pyrrolidin-2-yl] acetic acid, N-(difluoromethylsulfonyl)-2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-[2-(1,3-benzodioxol-5-yl) ethyl]-2-[1-[(2,3- difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, butan-2-yl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, N-butan-2- yl-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl] acetic acid, 2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, (2S)-3-(1H-indol-3-yl)-2-[ [2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionic acid, (2R)-2-[[2-[1-[(3-methylphenyl)methyl] -5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, 2-[1-[(4-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(trifluoromethylsulfonyl)acetamide, 2- [1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(furan-2-ylmethyl)acetamide, (2S)-2-[[2-[(2R)-1 -[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentanoic acid, 2-[5-oxo-1-[[3-(pentafluoro-λ6-sulfanyl)phenyl]methyl ]pyrrolidin-2-yl]acetic acid, 2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazole-5 -yl)ac etamide, 1-[(4-tert-butylphenyl)methyl]-5-[2-oxo-2-(2-thiophen-2-ylazepan-1-yl)ethyl]pyrrolidin-2-one, 2-[1- [(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2 -(1H-indol-3-yl)ethyl]acetamide, 2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, pentan-2-yl 2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 1-[(4-methylphenyl)methyl]-5-(2-oxo-2-pyrrolidin-1-ylethyl)pyrrolidin-2-one , 2-[5-oxo-1-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5 -oxopyrrolidin-2-yl]-N-propylacetamide, N-(difluoromethylsulfonyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2 ,2-difluoro-1,3-benzodioxol-5-yl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(3-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl] -N-(dimethylsulfamoyl)acetamide, N-[(2-fluorophenyl)methyl]-2-[5-oxo-1-[(4-phenylphenyl)methyl]pyrrolidin-2-yl]acetamide, N-butane-2- yl-2-[1-[(4-methylp phenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(4-methoxyphenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, N -[2-(2-fluorophenyl)ethyl ]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-(2,6-difluorophenyl)ethyl]-2-[1-[(2, 3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(2-fluorophenyl) methyl]acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N -[2-(3-methylphenyl)ethyl]acetamide, (2R)-4-methyl -2-[[2-[(2R)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentanecarboxylic acid, N-(dimethylsulfamoyl)-2-[1-[( 3-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-benzhydryl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-methyl-2 -[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-phenylacetamide, 1-[(2,4-dichlorophenyl)methyl]-5-[2-(4-methylpiperazine-1 -yl)-2-oxoethyl]pyrrolidin-2-one, [(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl] 2-[(2S)-1-[(2,3-difluorophenyl)methyl] -5-ox opyrolidin-2-yl]acetate, 2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[2-[3-(trifluoromethoxy)phenyl]ethyl]acetamide, 2-[5-oxo-1-[[4-(pentafluoro-λ6-sulfanyl)phenyl]methyl]pyrrolidine -2-yl]acetic acid, 4-[[2-(carboxymethyl)-5-oxopyrrolidin-1-yl]methyl]benzoic acid, N -[2-(3,4-dichlorophenyl)ethyl]-2-[1-[ (4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -cyclopropyl-2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2- [1-[[3-fluoro-2-(trifluoromethyl)phenyl]methyl]-5-oxopyrrolidine-2- yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-indan-1-ylacetamide, 2-[1-[(2,3-difluorophenyl) methyl]-5-oxopyrrolidin-2-yl]-N-(quinolin-6-ylmethyl)acetamide, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (furan-2-ylmethyl)acetamide, (2R)-4-methyl-2-[[2-[(2S)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino ]pentanecarboxylic acid, 2-[5-oxo-1-(pyridin-4-ylmethyl)pyrrolidin-2-yl]acetic acid, 2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid , 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2,2,2-trifluoroethyl)acetamide, tert-butyl (2S)-2-[[2- [1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(4-hydroxyphenyl)propionate, N -[2-(4-tert-butylphenyl)ethyl] -2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[5-oxo-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]acetic acid , 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, methyl (2S)-2-[[2-[1-[(4-isopropylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl] amino]-4-methylpentanoate, [(Z)-[3-(dimethylamino)propylamino]-(ethylimino)methyl] 2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl] acetate, N -[(2-ethylphenyl)methyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[(2R)-1-[(2, 3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, 2-[1-[(4-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamide, N -cyclopropyl-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, (2S)-2-[[2-[1-[(4-methylphenyl)methyl ]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, 2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]- 3-phenylpropionic acid, 3-methylbutan-2-yl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, methyl 3-[[2-[1-[(4-methylphenyl )methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionate, 2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(difluoromethylsulfonyl)acetamide, (2R)-2-[[2-[(2S)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]a mino]-3-phenylpropionic acid, 2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylsulfanylbutyric acid, (2R)-2-[[ 2-[(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, 2-[1-[(2,4-dichlorophenyl)methyl] -5-oxopyrrolidin-2-yl]-N-ethylacetamide, 2-[1-[1-(4-fluorophenyl)ethyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(2,6 -difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[1-(3-fluorophenyl)ethyl]-5-oxopyrrolidin-2-yl]acetic acid, 1-[2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]pyrrolidine-2-carboxylic acid, 2-[1-[(4-cyanophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-isopropylacetamide, ethyl 1-[2-[1-[(2,3-difluorophenyl)methyl]-5 -oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylate, 2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, (2S)-2-[[(2S) -2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentanoyl]amino]-4- methylpentanoic acid, 2-[5-oxo-1-[[4-(trifluoromethylthio)phenyl]methyl]pyrrolidin-2-yl]acetic acid, 2-[1-[(4-chlorophenyl)methyl]-5-oxopyrrolidin-2- yl]-N-(difluoromethylsulfonyl)acetamide, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(trifluoromethylsulfonyl)acetamide, 2-[(2S)-1-[ (2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamide, (2R)-2-[[ 2-[(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentanecarboxylic acid, (2S)- 2-[[2-[(2S)- 1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, 2- [1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]- N -[2-(2-fluorophenyl)ethyl]acetamide, 1-[(2,4-dichlorophenyl)methyl]-5-[2-oxo-2-(2-propylpyrrolidin-1-yl)ethyl]pyrrolidine-2 -one, methyl 2-[[2-[(2S)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]methylamino]acetate, 2-[1-[( 2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamide, 2-[1-[(4-methylphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl ]-N-methylsulfonylacetamide, N -[2-(2,6-difluorophenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -cyclopropyl-2 - [1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[(2S)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl ]-N-methylsulfonylacetamide, ethyl 1-[2-[(2R)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylate, methyl 2-[ [2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]benzoate, 2-[1-[(4-methylphenyl)methy 1]-5-oxopyrrolidin-2-yl]-N-phenylacetamide, N-[(6-chloropyridin-3-yl)methyl]-N-methyl-2-[1-[(4-methylphenyl)methyl]-5 - oxopyrrolidin-2-yl]acetamide, N-benzhydryl-2-[(2S)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-cyclopropyl-2-[ 1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[1-(3,4-difluorophenyl)ethyl]-5-oxopyrrolidin-2-yl]acetic acid, 2 -[1-[(2,3-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamide, (2S)-1-[2-[1-[(4-methylphenyl)methyl ]-5-oxopyrrolidin-2-yl]acetyl]pyrrolidin-2-carboxylic acid, 2-[1-[(3,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, N-[2-( 5-methoxy-1H-indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[(2-fluorophenyl)methyl]- 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-(1-benzyl-5-oxopyrrolidin-2-yl)-N-(2-phenylethyl)acetamide, 2 -[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N,N-dimethylacetamide, N-(dimethylsulfamoyl)-2-[1-[(4-methylphenyl)methyl]- 5-ox opyrrolidin-2-yl]acetamide, methyl (2R)-2-[[2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionate, methyl ( 2R)-2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionate, N',N'-dimethyl-2-[1 -[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetohydrazide, N-benzhydryl-2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, ethyl 1 - [2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylate, 4-methyl-2-[[2-[1-[(4-methylphenyl )methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentanecarboxylic acid, 2-[(2R)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl -N-phenylacetamide, N-cyclopropyl-2-[(2S)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-ethyl-2-[1-[( 4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-methyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-(isoquinoline- 5-ylmethyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-(cyclohexylmethyl)-2 -[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, (2S)-2-[[(2R)-2-[[2-[1-[(2- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropionic acid, N -[2-(4-fluorophenyl)ethyl]-2-[1-[(4 -methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-benzhydryl-2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[(2S) -1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamide, 2-[1-[(2-fluorophenyl)methyl]-5-oxo-3 -phenylpyrrolidin-2-yl]-N-methylsulfonylacetamide, 1-[(2- chlorophenyl)methyl]-5-[2-[2-(3,4-dichlorophenyl)azepan-1-yl]-2-oxoethyl]pyrrolidin-2-one, methyl 2-[[2-[(2R)-1 -[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]methylamino]acetate, 2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]- N-methyl-N-phenylacetamide, N-(2-methoxyethyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, ethyl 1-[2-[(2S) -1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylate, (2S)-4-methyl-2-[[2-[1-[(2 -methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentanecarboxylic acid, N-allyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2- [1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-methoxyethyl)acetamide, 2-[1-[(4-tert-butylphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[(4-fluorophenyl)methyl]acetamide, N-cyclohexyl-2-[5-oxo-1-[[3-(trifluoromethyl)phenyl]methyl]-pyrrolidin-2-yl] acetamide, N -[2-(2-bromophenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(4-methylphenyl) methyl]- 5-oxopyrrolidin-2-yl]-N-[2-[3-(trifluoromethoxy)phenyl]ethyl]acetamide, N-benzhydryl-2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamide, 2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamide, (2R)-3-(1H-indol-3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionic acid, (2S )-2-[[2-[(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, N-benzhydryl-2-[(2R )-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-(1H-indol-3-yl)ethyl]-2-[1-[(4 -methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[5-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidin-2-yl]acetic acid, methyl 2-[[2 -[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]methylamino]acetate, N -[3-(diethylamino)propyl]-2-[1-[(2,3- difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, (2S)-2-[[ 2-[(2S)-1-[(2-ethylphenyl)methyl]-5-ox opyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(quinolin-6-ylmethyl)acetamide, N -[(2,4-difluorophenyl)methyl]-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2,3-difluorophenyl )methyl]-5-oxopyrrolidin-2-yl]-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide, methyl 4-[[2-[1-[(4-methylphenyl )methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]butyrate, tert-butyl (2S)-3-(4-hydroxyphenyl)-2-[[2-[1-[(4-methylphenyl)methyl] -5-oxopyrrolidin-2-yl]acetyl]amino]propionate, N-[(2-fluorophenyl)methyl]-2-[5-oxo-1-[[3-(trifluoromethyl)phenyl]methyl]pyrrolidine-2- yl]acetamide, [(1S,2R,5R)-2-isopropyl-5-methylcyclohexyl] 2-[(2S)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate , ethyl 1-[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylate, 2-[[2-[1-[(4-ethylphenyl) methyl]-5-oxopyrrolidin-2-yl]acetyl]methylamino]acetic acid, N -methyl-2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-phenylaceta mid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-phenylacetamide, methyl 2-[methyl-[2-[1-[(3-methylphenyl)methyl ]-5-oxopyrrolidin-2-yl]acetyl]amino]acetate, (2R)-2-[[2-[(2S)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl] acetyl]amino]-4-methylpentanoic acid, N-cyclopropyl-2-[(2R)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-cyclopropyl-2-[ 1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, (2R,3R)-2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2 -yl]acetyl]amino]-3- methylpentanecarboxylic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-[3-(trifluoromethyl)phenyl]ethyl]acetamide, N-[2- (diethylamino)ethyl]-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[(2,4-difluorophenyl)methyl]-2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-[1-[(4-methylphenyl )methyl]-5-oxopyrrolidin-2-yl]acetamide, N-benzhydryl-2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, (2R,3R)-2- [[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-methylpentanoic acid, N -[(1-ethyl-1H-pyrazol-3-yl)methyl ]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-[2-(diethylamino)ethyl]-2-[1-[(4-methylphenyl)methyl] -5-oxopyrrolidin-2-yl]acetamide, (2S,3S)-3-methyl-2-[[2-[(2S)-1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl ]acetyl]-amino]pentanoic acid, N-cyclopropyl-2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-[2-(3,5-dimethoxyphenyl)ethyl] -2-[1 -[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[5-oxo-3-phenyl-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]acetic acid, ethyl 1 -[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylate, methyl 2-[[2-[1- [(6-chloropyridin-3- yl)methyl]-5-oxopyrrolidin-2-yl]acetyl]methylamino]acetate, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(isoquinoline- 5-ylmethyl)acetamide, 2-[1-[(6-chloropyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamide, N-cyclopropyl-2-[1- [(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-benzhydryl-2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, ethyl 1- [2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylate, 2-[5-oxo-1-[[5-(trifluoromethyl)pyridine-2 -yl]methyl]pyrrolidin-2-yl]acetic acid, 2-[[2-[(2S)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylamino] acetic acid, ethyl 2-(1-benzyl-5-oxopyrrolidin-2-yl)propionate, N-(cyclohexylmethyl)-2-[1-[(4-methylp phenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, ethyl 1-[2-[1-[(6-chloropyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2 -carboxylate, N-benzhydryl-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-(3-methylbutyl)-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -cyclopropyl-2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[( 4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, 2-[1-[(5-methoxypyridin-2-yl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2- [5-oxo-1-[[2-(trifluoromethyl)phenyl]methyl]pyrrolidin-2-yl]acetic acid, 2-[1-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-5-oxopyrrolidine -2-yl]acetic acid, 2-[1-[[5-fluoro-2-(trifluoromethyl)phenyl]methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[5-oxo-1-[[4 -(2,2,2-trifluoroethoxy)phenyl]methyl]pyrrolidin-2-yl]acetic acid, N-methylsulfonyl-2-[5-oxo-3-phenyl-1-(pyridin-2-ylmethyl)pyrrolidin-2- yl]acetamide, N -[3-(diethylamino)propyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrr olidin-2-yl]acetamide, 2-[1-[(3,4-difluorophenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methylsulfonylacetamide, 2-[5-oxo-1- (pyridin-2-ylmethyl)pyrrolidin-2-yl]propionic acid, 2-[1-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-(1-benzyl-5-oxopyrrolidin-2-yl)propionic acid, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(quinolin-5-ylmethyl)acetamide , 2-[1-[(6-chloropyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]-N-cyclopropylacetamide, N-methylsulfonyl-2-[5-oxo-3-phenyl-1-( pyridin-3-ylmethyl)pyrrolidine-2- yl]acetamide, methyl (2R)-2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionate, 2-[1-[ (3-fluorophenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methylsulfonylacetamide, 2-[[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl ]acetyl]-methylamino]acetic acid, N-methyl-2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-phenylacetamide, 2-[1-[(3-methylphenyl) methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, methyl 2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]methylamino]acetate, 2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamide, 2-[1 -[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1-[ (4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]propionic acid, 2-[1-[(4-fluorophenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methylsulfonylacetamide, 2 -[1-[(2,6-difluorophenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methylsulfonylacetam id, 2-[1-[(3,4-difluorophenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]acetic acid, methyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidine -2-yl]propionate, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(4-fluorophenyl)ethyl]acetamide, 2-[1 -[(2,3-difluorophenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl] -N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide, 2-[1-[(6-chloropyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]- N-methylsulfonylacetamide, 2-[1-[(6-chloropyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazole-5- yl)acetamide, (2S,3S)-2-[[2-[1-[(6-chloropyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-methylpentanecarboxylic acid, 2 -[1-[(6-chloropyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, N-benzhydryl-2-[1-[(6-chloropyridin-3-yl)methyl]-5 -oxopyrrolidin-2-yl]acetamide, 2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamide, ethyl 1-[2-[1-[ (4-isopropylphenyl)methyl]-5-oxopyrr olidin-2-yl]acetyl]piperidine-2-carboxylate, 2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2, 4-triazol-5-yl)acetamide, methyl 2-[[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]methylamino]acetate, methyl 2-[methyl- [2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]acetate, 2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidine -2-yl]acetyl]methylamino]acetic acid, 2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamide, 2-[1-[( 4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetamide, ethyl 1-[2-[1-[( 3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylate, 5-[2-[4-(4-chlorophenyl)piperazin-1-yl]-2-oxoethyl]-1- [(2,4-dichlorophenyl)methyl]pyrrolidin-2-one, N -cyclohexyl-2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 1-[( 2,4-dichlorophenyl)methyl]-5-(2-oxo-2-piperidin-1-ylethyl)pyrrolidin-2-one, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin- 2-yl]-N-(2- pyrrolidin-1-ylethyl)acetamide, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-2-ylethyl)acetamide, 1-[( 4-tert-butylphenyl)methyl]-5-[2-[2-(4-methoxyphenyl)azepan-1-yl]-2-oxoethyl]pyrrolidin-2-one, 2-[1-[(2,4- dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-ethylbutyl)acetamide, 5-[2-[2-(3,4-dichlorophenyl)azepan-1-yl]-2-oxoethyl]- 1-[[3-(trifluoromethyl)phenyl]methyl]pyrrolidin-2-one, 1-[(2,4-difluorophenyl)methyl]-5-[2-(2- isopropylpyrrolidin-1-yl)-2-oxoethyl]pyrrolidin-2-one, 5-[2-[2-(3,4-dichlorophenyl)azepan-1-yl]-2-oxoethyl]-1-[(4- phenylphenyl)methyl]-pyrrolidin-2-one, N,N-dibenzyl-2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]acetamide, benzyl-N-[2-[[ 2-[5-oxo-1-[[3-(trifluoromethyl)phenyl]methyl]pyrrolidin-2-yl]acetyl]amino]ethyl]carbamate, 1-[(4-tert-butylphenyl)methyl]-5- [2-oxo-2-(4-pyridin-2-ylpiperazin-1-yl)ethyl]pyrrolidin-2-one, N-(2-bicyclo[2.2.1]heptanyl)-2-[5-oxo-1 -(pyridin-2-ylmethyl)pyrrolidin-2-yl]acetamide, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1R)-1- cyclohexylethyl]acetamide, 2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-ethyl-N-propylacetamide, 1-[(2-chlorophenyl)methyl]-5- [2-[2-(2-methylpropyl)pyrrolidin-1-yl]-2-oxoethyl]pyrrolidin-2-one, 1-[(4-tert-butylphenyl)methyl]-5-[2-(2,6 -dimethylmorpholin-4-yl)-2-oxoethyl]pyrrolidin-2-one, 1-benzyl-5-[2-[2-(3,4-dichlorophenyl)pyrrolidin-1-yl]-2-oxoethyl]pyrrolidin- 2-one, 2-[5-oxo-1-[(4-phenylphenyl)methyl]pyrrole idin-2-yl]-N-pentylacetamide, N-(2-bicyclo[2.2.1]heptanyl)-2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide , 5-[2-(1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinolin-2-yl)-2-oxoethyl]-1-[(4-methylphenyl)methyl]pyrrolidine -2-one, 5-[2-(2-ethylpiperidin-1-yl)-2-oxoethyl]-1-[(4-phenylphenyl)methyl]pyrrolidin-2-one, 5-[2-oxo-2- (2-propylpyrrolidin-1-yl)ethyl]-1-[(4-phenylphenyl)methyl]pyrrolidin-2-one, N-(cyclohexylmethyl)-2-[1-[(2,4-dichlorophenyl)methyl]- 5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2,3-dimethylcyclohexyl)acetamide, 1-benzyl- 5-(2-isoindolin-2-yl-2-oxoethyl)pyrrolidin-2-one, N,N-dibenzyl-2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl ]acetamide, 1-[(2,4-difluorophenyl)methyl]-5-[2-[2-(3-methoxyphenyl)azepan-1-yl]-2-oxoethyl]pyrrolidin-2-one, N-(2 ,3-dimethylcyclohexyl)-2-[5-oxo-1-[(4-phenylphenyl)methyl]pyrrolidin-2-yl]acetamide, 5-[2-[2-(3,4-dichlorophenyl)pyrrolidine-1 -yl]-2-oxoethyl]-1-[[3-(trifluoromethyl)phenyl]methyl] pyrrolidin-2-one, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-ethylhexyl)acetamide, N-(2-bicyclo[2.2.1 ]heptanyl)-2-[1-[(2,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 5-[2-[2-(3,4-dichlorophenyl)azepan-1-yl ]-2-oxoethyl]-1-[(2,4-difluorophenyl)methyl]pyrrolidin-2-one, N-[(1R)-1-cyclohexylethyl]-2-[5-oxo-1-[(1R) - 1-phenylethyl]pyrrolidin-2-yl]acetamide, N-benzyl-2-(1-benzyl-5-oxopyrrolidin-2-yl)-N-methylacetamide, 2-(1-benzyl-5-oxopyrrolidin-2- yl)-N-(pyridin-2-ylmethyl)acetamide, N,N-diethyl-1-[2-[5-oxo-1-[[3-(trifluoromethyl)phenyl]methyl]pyrrolidin-2-yl]acetyl ]piperidine-3-carboxamide, 2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(2-methylphenyl)methyl]acetamide, 2-[1-[ (4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-morpholin-4-ylethyl)acetamide, 2-[1-[(4-tert-butylphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[(2-fluorophenyl)methyl]acetamide, 1-[(2,4-difluorophenyl)methyl]-5-[2-(3,5-dimethylpiperidin-1-yl)-2 -oxoethyl]pyrrolidin-2-one, 1-[(2,4-dichlorop henyl)methyl]-5-(2-morpholin-4-yl-2-oxoethyl)pyrrolidin-2-one, 2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl] -N-pentan-3-ylacetamide, 2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(3,3-dimethylbutyl)acetamide, 1-[(4 -tert-butylphenyl)methyl]-5-(2-oxo-2-thiomorpholin-4-ylethyl)pyrrolidin-2-one, N-ethyl-2-[5-oxo-1-[[3-(trifluoromethyl)- phenyl]methyl]pyrrolidin-2-yl]acetamide, 1-benzyl-5-(2-oxo-2-thiomorpholin-4-ylethyl)pyrrolidin-2-one, 5-[2-[4-(4-chlorophenyl)piperazin-1-yl]-2-oxoethyl]-1-[(1R)-1-phenylethyl]pyrrolidin-2-one, 2-[1-[(4 -tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(5-methylhexan-2-yl)acetamide, 2-[1-[(2-chlorophenyl)methyl]-5-oxopyrrolidin-2- yl]-N-cyclohexylacetamide, 2-[1-[(2-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N,N-dimethylacetamide, N-benzyl-2-[1-[(2,4 -dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-cyclopentylacetamide, N-[(4 -fluorophenyl)methyl]-2-[5-oxo-1-[[3-(trifluoromethyl)phenyl]methyl]pyrrolidin-2-yl]acetamide, 1-[(2,4-dichlorophenyl)methyl]-5-[ 2-oxo-2-[4-(pyridin-2-ylmethyl)piperazin-1-yl]ethyl]pyrrolidin-2-one, 2-[1-[(2,4-difluorophenyl)methyl]-5-oxopyrrolidin- 2-yl]-N-(3,3,5-trimethylcyclohexyl)acetamide, 2-[1-[(2-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[3-(dimethylamino)propyl ]acetamide, 2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-phenylethyl)acetamide, N-benzyl-2-[1-[(2, 4-dichlorophenyl)methyl]-5-oxopyr rolidin-2-yl]-N-methylacetamide, 1-[(4-tert-butylphenyl)methyl]-5-(2-oxo-2-pyrrolidin-1-ylethyl)pyrrolidin-2-one, 2-[1- [(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(oxolan-2-ylmethyl)acetamide, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidine -2-yl]-N-[(2-chlorophenyl)methyl]acetamide, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyrrolidin-1- ylethyl)acetamide, 2-[1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[3-(1H-imidazol-1-yl)propyl]acetamide, 2-[ 1-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(dimethylamino)ethyl]-N-methylacetamide, 1-[(4-tert-butylphenyl)methyl]- 5-(2-oxo-2-piperidin-1-ylethyl)pyrrolidin-2-one, (2S)-2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl ]acetyl]amino]-4-methylpentanecarboxylic acid, (2R,3R)-2-[[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-methylpentanecarboxylic acid , methyl (2S)-3-(1H-imidazol-4-yl)-2-[[2-[(2R)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl] amino]propionate, (2S)-2-[[2-[(2R)-1 -[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, 2-[[2-[(2R)-1-[(2,3-difluorophenyl)methyl] -5-oxopyrrolidin-2-yl]acetyl]methylamino]acetic acid, N-(2-bicyclo[2.2.1]heptanyl)-2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2- yl]acetamide, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1S)-1-cyclohexylethyl]acetamide, 2-[1-[(4 - methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-phenylethyl)acetamide, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-( 2-pyridin-3-ylethyl)acetamide, N -[2-(2-methoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[ 1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-2-ylethyl)acetamide, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidine -2-yl]-N-[2-[3-(trifluoromethyl)phenyl]ethyl]acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N- [2-[4-(trifluoromethoxy)phenyl]ethyl]acetamide, N-[2-(3-bromophenyl)ethyl]-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidine-2- yl]acetamide, N- [2-(2,5-dichlorophenyl)ethyl]-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2,3- difluoro-phenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-thiophen-2-ylethyl)acetamide, 2-[5-oxo-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl ]propionic acid, methyl 2-[5-oxo-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]acetate, methyl 2-[5-oxo-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl ]propionate, 2-[1-[(4-fluorophenyl)methyl]-5- oxopyrrolidin-2-yl]propionic acid, N -[2-(3,4-dimethoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[ 1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(2-methoxyphenyl)ethyl]acetamide, 2-[1-[(2,3-difluorophenyl)methyl ]-5-oxopyrrolidin-2-yl]-N-[2-(3,4-methoxyphenyl)ethyl]acetamide, 2-[1-[(4-fluorophenyl)methyl]-5-oxo-3-phenylpyrrolidine- 2-yl]acetic acid, 2-[1-[(2-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionic acid, 2-(1-benzyl-5-oxo-3-phenylpyrrolidin-2-yl)- N-methylsulfonylacetamide, 2-[1-[(2,4-difluorophenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methylsulfonylacetamide, methyl 4-[[2-[1-[(2 ,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]butyrate, N -[2-(4-chlorophenyl)ethyl]-2-[1-[(2,3-difluorophenyl)methyl ]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-3-ylethyl)acetamide, N -[2-(2,5-dichlorophenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(3-fluorophenyl )methyl]-5-oxo-3-phenylpyrrolidin-2-yl]acetic acid, methyl 2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionate, methyl 2-[1 -[(3-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionate, 2-[1-[(2,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionic acid, 2-[1 - [(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionic acid, 2-[1-[(3-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionic acid, 2-[1 -[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionic acid, 2-[1-[(2,6-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionic acid, 2- (1-benzyl-5-oxo-3-phenylpyrrolidin-2-yl)acetic acid, N -[2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl]-2-[1-[( 4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl]-2-[1-[(2, 3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[1-(3,5-difluorophenyl)ethyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-[1- [(2,3-difluorophenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methylsulfonylacetamide, methyl 2-[1-[(2,4-difluo rphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, methyl 2-[1-[(2,6-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionate, N-[2-(2, 4-difluorophenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-(3-bromophenyl)ethyl]-2-[1-[ (4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(4 -methoxyphenyl)ethyl]acetamide, methyl 2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]propionate, 4-[[2-[1-[(4-methylphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetyl]amino]butyric acid, methyl 2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]acetate, 2-[1-[(2-fluorophenyl )methyl]-5-oxo-3-phenylpyrrolidin-2-yl]acetic acid, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(3 -methoxyphenyl)ethyl]acetamide, N -[2-(2,3-dichlorophenyl)ethyl]-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2- [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-[4-(trifluoromethoxy)-phenyl]ethyl]acetamide, methyl 2-[1-[(2-fluorophenyl )meth yl]-5-oxopyrrolidin-2-yl]propionate, N -[2-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin- 2-yl]acetamide, N -[2-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide , 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(4-methylphenyl)ethyl]acetamide, methyl 2-[1-[(4- fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionate, methyl 2-[1-[(2,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionate, methyl 2-[1-[( 2,6-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1-[(2,4-difluorophenyl)methyl]- 5-oxo-3-phenylpyrrolidin-2-yl]acetic acid, 2-[1-[(4-methylphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]acetic acid, N-[2-(3 -methoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-(3-chlorophenyl)ethyl]-2-[1-[( 2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-(3-chlorophenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidine- 2-yl]acetamide, N -[2-(4-methoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-(2 - chlorophenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-[2-(4-methylphenyl)ethyl]-2-[1-[( 4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-(2-chlorophenyl)ethyl]-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidine- 2-yl]acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-2-ylethyl)acetamide, N-[2- (2,4-dichlorophenyl)ethyl]-2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-(4-chlorophenyl)ethyl]- 2-[1-[(4-methylphenyl)methyl]-5-oxopy rrolidin-2-yl]acetamide, 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(3-fluorophenyl)ethyl]acetamide, N-[ 2-(2,4-dichlorophenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-(3-fluorophenyl)ethyl]-2 -[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2 -thiophen-2-ylethyl)acetamide, (2R)-2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, 2- (1-benzyl-5-oxopyrrolidin-2-yl)-N-(oxolan-2-ylmethyl)acetamide, 2-(1-benzyl-5-oxopyrrolidin-2-yl)-N-cyclohexylacetamide, N-(2, 2-difluoroethyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-(2,2-difluoroethyl)-2-[1-[(2,3- difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, [5-oxo-1-(2,3,6-trifluorobenzyl)pyrrolidin-2-yl]acetic acid, [5-oxo-1-(2,3 ,4-trifluorobenzyl)pyrrolidin-2-yl]acetic acid, [5-oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin-2-yl]acetic acid, [5-oxo-1-(2,3-dimethylbenzyl). )pyrrolidin-2-yl]ess ig acid, N-[(4-chlorophenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamide, 1-benzyl-5-oxo-N-[[3-(trifluoromethyl)phenyl]methyl] pyrrolidine-3-carboxamide, N-[(2,3-dichlorophenyl)methyl]-5-oxo-1-phenylpyrrolidine-3-carboxamide, 1-[2-(4-chlorophenyl)ethyl]-N-[(3, 5-dimethoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamide, N -[(3,5-dichlorophenyl)methyl]-5-oxo-1-prop-2-yn-1-ylpyrrolidine-3-carboxamide, 1- [(4-chlorophenyl)methyl]-5-oxo-N-(pyridin-3-ylmethyl)pyrrolidine-3-carboxamide, 1-benzyl-N-[(5-methylpyrazin-2-yl)methyl]-5-oxopyrrolidine -3-carboxamide, 1-(1,3-benzodioxol-5-ylmethyl)-N-[(2,3-dichlorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide, 1-benzyl-N-methyl-5- oxo-N-(pyridin-4-ylmethyl)pyrrolidine-3-carboxamide, 1-[(4-chlorophenyl)methyl]-N-[(2-methoxyphenyl)methyl]-N-methyl-5-oxopyrrolidine-3-carboxamide , 1-(4-methylphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide, N -[(4-methoxyphenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidine -3-carboxamide, 1-benzyl-N-[(2,3-dichloropheny l)methyl]-5-oxopyrrolidine-3-carboxamide, N-benzyl-1-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamide, 1-benzyl-N-[(2,5-dichlorophenyl)methyl]- 5-oxopyrrolidine-3-carboxamide, N-[(2-chlorophenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamide, N-[(2,4-dichlorophenyl)methyl]-1- (2-methylpropyl)-5-oxopyrrolidine-3-carboxamide, N-[(3-chloro-4-fluorophenyl)methyl]-1-ethyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-dimethylphenyl) -5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3- carboxamide, 1-[2-(4-fluorophenyl)ethyl]-5-oxo-N-(pyridin-3-ylmethyl)pyrrolidine-3-carboxamide, N -[(2,5-dichlorophenyl)methyl]-5-oxo -1-phenylpyrrolidine-3-carboxamide, N-[(3,4-dichlorophenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamide, 1-cyclopropyl-N-[(4-methylphenyl) methyl]-5-oxopyrrolidine-3-carboxamide, 1-butan-2-yl-N-[(4-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide, 1-ethyl-N-[(4-methylphenyl) methyl]-5-oxopyrrolidine-3-carboxamide, 5-oxo-N-[indan-1-yl]-1-[3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamide, N-[(2,3-difluorophenyl )methyl]-1-ethyl-5-oxopyrrolidine-3-carboxamide, 1-butan-2-yl-N-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide, 1-cyclopropyl-N -[(2,3-difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide, N-[(2,3-difluorophenyl)methyl]-1-isopropyl-5-oxopyrrolidine-3-carboxamide, 1-[3, 5-bis(trifluoromethyl)phenyl]-5-oxo-N-[[2-(trifluoromethoxy)pyridin-4-yl]methyl]pyrrolidine-3-carboxamide, N-[(2-chloropyridin-4-yl)methyl] -6-(3,5-dichlorophenyl)-2,4-dimet hyl-7-oxo-6-azabicyclo[3.2.1]oct-3-ene-8-carboxamide, 1-[3,5-bis(trifluoromethyl)phenyl]-N-[[2-(ethylamino)pyrimidine-4 -yl]methyl]-5-oxopyrrolidine-3-carboxamide, 1-(4-fluorophenyl)-5-oxo-N-[indan-1-yl]pyrrolidine-3-carboxamide, 1-(2,4-difluorophenyl) -N-[indan-1-yl]-5-oxopyrrolidine-3-carboxamide, N-[(6-chloropyridin-3-yl)methyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide, N -[(2-chlorophenyl)methyl]-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide, 1-[3-(difluoromethoxy)phenyl]-5-oxo-N-[indan-1-yl ]pyrrolidine-3-carboxamide, (3RS)-1-(2,4-difluorophenyl)-N-[(1R*)-indan-1-yl]-5-oxopyrrolidine-3-carboxamide, 1-[3-( difluoromethyl)phenyl]-5-oxo-N-[indan-1-yl]pyrrolidine-3-carboxamide, N-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]-1-[3 -(difluoromethoxy)phenyl]-5-oxopyrrolidine-3-carboxamide, N -[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]-5-oxo-1-[3-(trifluoromethyl)phenyl ]pyrrolidine-3-carboxamide, N,3-dimethyl-5-oxo-1-phenyl-N-[1,2,3,4-tetrahydronaphthalen-1-yl]pyrrolidine-3-carboxamide d, 1-butan-2-yl-N-[(3-chloro-4-fluorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide, 1-benzyl-N-[(2-chlorophenyl)methyl]-5- oxopyrrolidine-3-carboxamide, N -[(3-chloro-4-fluorophenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamide, N -[(3-chloro-4-fluorophenyl)methyl ]-1-isopropyl-5-oxopyrrolidine-3-carboxamide, N-[(4-chlorophenyl)methyl]-5-oxo-1-phenylpyrrolidine-3-carboxamide, N-benzyl-5-oxo-1-phenylpyrrolidine-3 - carboxamide, N-[(4-chlorophenyl)methyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide, N-benzyl-1-(4-chlorophenyl)-5-oxopyrrolidine-3-carboxamide, N-[(4-fluorophenyl)methyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide, N-benzyl-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide, 1-( 4-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamide, N-[(5-chloro-2-methylphenyl)methyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine -3-carboxamide, N-[(2,4-dichlorophenyl)methyl]-5-oxo-1-phenylpyrrolidine-3-carboxamide, N-[(2,4-dichlorophenyl)methyl]-1-(4-methoxyphenyl) -5-oxopyrr olidine-3-carboxamide, 1-(4-methoxyphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide, 5-oxo-1-phenyl-N-(pyridin-2-ylmethyl) pyrrolidine-3-carboxamide, N-[(2,3-difluorophenyl)methyl]-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide, N-[(2,3-difluorophenyl)methyl]-1- (4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide, N -[(2-chlorophenyl)methyl]-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide, 1-cyclopentyl-5-oxo-N -(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide, 1-(4-fluorophenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3- carboxamide, 1-(4-chlorophenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide, 1-(4-chlorophenyl)-N-[(2,5-dichlorophenyl)methyl]- 5-oxopyrrolidine-3-carboxamide, 1-(4-chlorophenyl)-N-[(6-chloropyridin-3-yl)methyl]-5-oxopyrrolidine-3-carboxamide, N-[(2,5-dichlorophenyl)methyl ]-1-(2,4-difluorophenyl)-5-oxopyrrolidine-3-carboxamide, N-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]-1-(2-methylpropyl)- 5-oxopyrrolidine-3-carboxamide, N -[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]-1-cyclopentyl-5-oxopyrrolidine-3-carboxamide, 1-(2,4-difluorophenyl )-N-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide, 1-[3-(difluoromethoxy)phenyl]-N-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidine -3-carboxamide, N-[(2,5-dichlorophenyl)methyl]-5-oxo-1-[3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamide, 1-[3-(difluoromethyl)phenyl]- N -[(2,3-difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide, N -[(2-chlorophenyl)methyl]-1-[3-(difluoromethoxy)phenyl]-5-oxopyrrolidine-3-carboxamide , N-[(2,6-dichlorophenyl)methyl l]-1-[3-(difluoromethoxy)phenyl]-5-oxopyrrolidine-3-carboxamide, N-[(2,6-dichlorophenyl)methyl]-1-[3-(difluoromethyl)phenyl]-5-oxopyrrolidine- 3-carboxamide, N -[(2-chlorophenyl)methyl]-1-(2,4-difluorophenyl)-5-oxopyrrolidine-3-carboxamide, N -[(2,6-dichlorophenyl)methyl]-1-(4 -fluorophenyl)-5-oxopyrrolidine-3-carboxamide, N-[(2,5-dichlorophenyl)methyl]-1-[3-(difluoromethoxy)phenyl]-5-oxopyrrolidine-3-carboxamide, N-[(2, 4-dichlorophenyl)methyl]-1-(2,4-difluorophenyl)-5-oxopyrrolidine-3-carboxamide, N -[(2,5-dichlorophenyl)methyl]-1-[3-(difluoromethyl)phenyl]-5 -oxopyrrolidine-3-carboxamide, N-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide, N-[(2 ,4-dichlorophenyl)methyl]-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide, N -[(2,5-dichlorophenyl)methyl]-1-(4-fluorophenyl)-5-oxopyrrolidine-3 -carboxamide, N-[(2,6-dichlorophenyl)methyl]-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide, N-[(2,6-dichlorophenyl)methyl]-1-(2, 4-difluorophenyl)-5-oxopyrrolidine-3-carboxa mid, N-[(2-chlorophenyl)methyl]-1-[3-(difluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxamide, 1-(4-chlorophenyl)-N-[[3-chloro-5- (trifluoromethyl)pyridin-2-yl]methyl]-5-oxopyrrolidine-3-carboxamide, N-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]-1-cyclobutyl-5-oxopyrrolidine- 3-carboxamide, 5-oxo-N-(pyridin-2-ylmethyl)-1-[3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamide, N -[(2,3-difluorophenyl)methyl]-5-oxo - 1-[3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamide, N-[(2,5-dichlorophenyl)methyl]-1-(2- methoxyphenyl)-5-oxopyrrolidine-3-carboxamide, N-[[ 3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]-1-(2,4-difluorophenyl)-5-oxopyrrolidine-3-carboxamide, N -[[3-chloro-5-(trifluoromethyl)pyridine -2-yl]methyl]- 1-[3-(difluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxamide, N-[(6-chloropyridin-3-yl)methyl]-1-(4-methylphenyl)- 5-oxopyrrolidine-3-carboxamide, N-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]-5-oxo-1-phenylpyrrolidine-3-carboxamide, N-[[3-chloro- 5-(trifluoromethyl)pyridin-2-yl]methyl]-1-(2-methoxy phenyl)-5-oxopyrrolidine-3-carboxamide, N-[(6-chloropyridin-3-yl)methyl]-1-cyclopentyl-5-oxopyrrolidine-3-carboxamide, N-[(2,4-dichlorophenyl)methyl] -1-[3-(difluoromethoxy)phenyl]-5-oxopyrrolidine-3-carboxamide, N-[(2-chlorophenyl)methyl]-1-cyclopentyl-5-oxopyrrolidine-3-carboxamide, 1-(2,4- difluorophenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide, 1-cyclobutyl-5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidine-3-carboxamide, 1-[3- (difluoromethyl)phenyl]-5- oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide, 1-[3-(difluoromethoxy)phenyl]-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide, 1-cyclopentyl -5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidine-3-carboxamide, 1-(2-methylpropyl)-5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidine-3-carboxamide, N-[ (6-chloropyridin-3-yl)methyl]-1-cyclobutyl-5-oxopyrrolidine-3-carboxamide, 1-(2-methylpropyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide , N -[(6-chloropyridin-3-yl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamide, N -[(6-chloropyridin-3-yl)methyl]-5-oxo -1-phenylpyrrolidine-3-carboxamide, 1-cyclobutyl-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide, N-[(2-cyclobutyloxypyridin-4-yl)methyl]-1-( 3,5-difluorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-difluorophenyl)-3-methyl-5-oxo-N-[[2-(2,2,2- trifluoroethoxy)pyridin-4-yl]methyl]pyrrolidine-3-carboxamide, 1-(3,5-difluorophenyl)-3-methyl-N-[(2-methylsulfanylpyrimidin-4-yl)methyl]-5-oxopyrrolidine-3 -carboxamide, N-[(2-chloropyrimidine-4 -yl)methyl]-1-(3,5-dichlorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-N-[[2-(ethylamino)pyrimidine-4 -yl]methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-difluorophenyl)-3-methyl-5-oxo-N-[(2-propoxypyridin-4-yl)methyl] pyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-N-[[2-(difluoromethoxy)-pyridin-4-yl]methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-( 3,5-dichlorophenyl)-N-[(2-ethoxypyrimidin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, N-benzyl-6-(3,5-dichlorophenyl)-N, 2,4-trimethyl-7-oxo-6-azabicyclo[3.2.1]oct-3-ene-8-carboxamide, 1-(3,5-difluorophenyl)-N-[(2-methoxypyridin-4-yl) methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-N-[(2-methoxypyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3- carboxamide, 1-(3,5-difluorophenyl)-N-[(2-ethoxypyrimidin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-difluorophenyl)-N -[(2-ethoxypyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-N-[(2-ethoxyp yridin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-3-methyl-N-[[2-(methylamino)pyrimidin-4-yl] methyl]-5-oxopyrrolidine-3-carboxamide, 1-(3,5-difluorophenyl)-N-[[2-(ethylamino)pyrimidin-4-yl]methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide , 1-(3,5-difluorophenyl)-N-[(2-isopropyloxypyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-difluorophenyl)-3- methyl-N-[[2-(methylamino)pyrimidin-4-yl]methyl]-5-oxopyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-N-[(2-ethylsulfanylpyrimidin-4-yl) methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-N-[[2-[ethyl(methyl)amino]pyridin-4-yl]methyl]-3-methyl -5-oxopyrrolidine-3-carboxamide, N-[(2-chloropyrimidin-4-yl)methyl]-1-(3,5-difluorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxamide, N-[( 2-chloropyridin-4-yl)methyl]-1-(3,5-difluorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxamide, N-[(2-chloropyridin-4-yl)methyl]-1- (3,5-dichlorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxamide, N-[(2-tert-butoxypyr idin-4-yl)methyl]-1-(3,5-difluorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-difluorophenyl)-N-[[2-[ethyl( methyl)amino]pyridin-4-yl]methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-difluorophenyl)-3-methyl-N-[(2-morpholin-4-ylpyridine -4-yl)methyl]-5-oxopyrrolidine-3-carboxamide, N -[(2-tert-butoxypyridin-4-yl)methyl]-1-(3,5-dichlorophenyl)-3-methyl-5-oxopyrrolidine -3-carboxamide, 1-(3,5-difluorophenyl)-N-[(2-isopropyloxypyrimidin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, N-[[2-(difluoromethoxy )pyridin-4-yl]methyl]-1-(3,5- difluorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3-chloro-5-methylphenyl)-N-[(2-chloropyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidine- 3-carboxamide, 1-(3,5-dichlorophenyl)-3-methyl-N-[(2-methylsulfanylpyrimidin-4-yl)methyl]-5-oxopyrrolidine-3-carboxamide, N-[(2-chloropyridine-4 - yl)methyl]-3-methyl-5-oxo-1-phenylpyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-3-methyl-5-oxo-N-[(2-propoxypyridine-4- yl)methyl]pyrrolidine-3-carboxamide, N-[(2-cyclobutyloxypyridin-4-yl)methyl]-1-(3,5-dichlorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-( 3,5-difluorophenyl)-N-[(2-ethylsulfanylpyrimidin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-N-[(2- isopropyloxypyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-N-[(2-isopropyloxypyrimidin-4-yl)methyl]-3-methyl- 5-oxopyrrolidine-3-carboxamide, 1-(3,5-difluorophenyl)-N-[[2-(4-fluorophenoxy)pyridin-4-yl]methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-N-[[2-(4-fluorophe noxy)pyridin-4-yl]methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide, N-benzyl-N,2,4-trimethyl-7-oxo-6-(3,4,5-trichlorophenyl) -6-azabicyclo[3.2.1]oct-3-ene-8-carboxamide, N-[[2-(ethylamino)pyrimidin-4-yl]methyl]-2,4-dimethyl-7-oxo-6-( 3,4,5-trichlorophenyl)-6-azabicyclo[3.2.1]oct-3-ene-8-carboxamide, 6-(3,5-dichlorophenyl)-N-[[2-(ethylamino)pyrimidine-4- yl]methyl]-2,4-dimethyl-7-oxo-6-azabicyclo[3.2.1]oct-3-ene-8-carboxamide, N-[(2-chloropyridin-4-yl)methyl]-2, 4-dimethyl-7-oxo-6-(3,4,5-trichlorophenyl)-6-azabicyclo[3.2.1]oct-3-ene-8-carboxamide, 1-(3,5-dichlorophenyl)-3- methyl-5-oxo-N-[[2-(2,2,2-trifluoroethoxy)pyridin-4-yl]methyl]pyrrolidine-3-carboxamide, 1-(3,5-dichlorophenyl)-3-methyl-N -[(2-morpholin-4-ylpyridin-4-yl)methyl]-5-oxopyrrolidine-3-carboxamide, 1-(4-chlorophenyl)-N-[(2-chlorophenyl)methyl]-5-oxopyrrolidine-3 -carboxamide, 1-(4-chlorophenyl)-N-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide, 1-(4-chlorophenyl)-N-[(4-chlorophenyl)methyl] -5-oxopyrrolidine-3-carboxamide, 1-(4-chlo rphenyl)-N-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamide, N-[(5-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-5-oxopyrrolidine-3 -carboxamide, N -[(4-fluorophenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide, N -[(4-chlorophenyl)methyl]-1-(4-methylphenyl)-5 - oxopyrrolidine-3-carboxamide, N-[(4-methoxyphenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide, N-[(5-chloro-2-methylphenyl)methyl]-1 -(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide, N-[(2,4-dichlorophenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide, N-[(2, 3-difluorophenyl)methyl]-1-methyl-5-oxopyrrolidine-3-carboxamide, 1-methyl-N-[(4-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide, 1-cyclopentyl-N-[( 4-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide, N-[(3-chloro-4-fluorophenyl)methyl]-1-cyclopentyl-5-oxopyrrolidine-3-carboxamide, N-[(3-chloro- 4-fluorophenyl)methyl]-1-methyl-5-oxopyrrolidine-3-carboxamide, 1-cyclopentyl-N-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide, N-[(5- c chloro-2-methylphenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamide, 1-cyclobutyl-N-[(4-fluorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide, N- benzyl-1-cyclobutyl-5-oxopyrrolidine-3-carboxamide, 1-cyclobutyl-N-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamide, N-[(4-chlorophenyl)methyl]-1- cyclobutyl-5-oxopyrrolidine-3-carboxamide, N-[(2-chlorophenyl)methyl]-1-cyclobutyl-5-oxopyrrolidine-3-carboxamide, N-[(4-fluorophenyl)methyl]-1-(2-methylpropyl )-5- oxopyrrolidine-3-carboxamide, 1-cyclobutyl-N-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide, N-[(5-chloro-2-methylphenyl)methyl]-1-cyclobutyl- 5-oxopyrrolidine-3-carboxamide, N -[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorophenyl)acetamide, 2-(2,5-dichlorophenyl)-N -[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]acetamide, 2-(2,5-dichlorophenyl)-N-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl ]acetamide, 2-(2,5-dimethylphenyl)-N-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)acetamide, N -[1-(4-cyanophenyl)-5-oxopyrrolidine-3 -yl]-2-(2,5-dichlorophenyl)acetamide, 2-(2,5-dichlorophenyl)-N-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]acetamide, 2-(2 ,5-dichlorophenyl)-N-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamide, 2-(2,5-dichlorophenyl)-N-[1-(4-methoxyphenyl)-5- oxopyrrolidin-3-yl]acetamide, 2-(2-chlorophenyl)-N-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]acetamide, N-[1-(4-chlorophenyl)-5- oxopyrrolidin-3-yl]-2-(2,5-dichlorophenyl)acetamide, 2-(2,5-dichlorophenyl)-N-[1-(3,5-difluorophenyl)-4-methyl-5-oxopyrr olidin-3-yl]acetamide, 2-(2-chlorophenyl)-N-[1-(3,5-difluorophenyl)-4-methyl-5-oxopyrrolidin-3-yl]acetamide, 2-(2,5- dichlorophenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acetamide, 2-(2,5-dichlorophenyl)-N-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]acetamide , 2-(2,5-dichlorophenyl)-N-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)acetamide, N -[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3 -yl]-2-(2-methylphenyl)acetamide, N -[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamide, N -[1-(4- cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylphenyl)acetamide, N -[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2-methylphenyl) acetamide, N-(1-cyclopropyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorophenyl)acetamide, 2-(2-chlorophenyl)-N-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]acetamide, N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorophenyl)acetamide, 2-(2-methylphenyl)-N-(5-oxo- 1-phenylpyrrolidin-3-yl)acetamide, 2-(2-chlorophenyl)-N-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]acetamide, N -[1-(3,5-difluorophenyl). )-5-oxopyrrolidine -3-yl]-2-(2,5-dimethylphenyl)acetamide, 2-(2,5-dimethylphenyl)-N-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]acetamide, 2- (2,5-dimethylphenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acetamide, N-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]-2-(2- methylphenyl)acetamide, 2-(2,5-dimethylphenyl)-N-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]acetamide, 2-(2,5-dichlorophenyl)-N-(1- isopropyl-5-oxopyrrolidin-3-yl)acetamide, N -[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylphenyl)acetamide, 2-(2-chlorophenyl) -N-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamide, 2-(2,5-dimethylphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)acetamide, N -(1-isopropyl-5-oxopyrrolidin-3-yl)-2-(2-methylphenyl)acetamide, 2-(2,5-dichlorophenyl)-N-[1-(2-methylpropyl)-5-oxopyrrolidin-3 -yl]acetamide, 2-(2-chlorophenyl)-N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)acetamide, 2-(2-chlorophenyl)-N-[2-(2-chlorophenyl)acetyl] -N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)acetamide, 2-(4-chlorophenyl)-N-[2-(4-chlorophenyl)acetyl]-N-[1-(2-methylpropyl)- 5-oxopyrrolidi n-3-yl]acetamide, 1-(4-fluorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(4-bromo-3-methylphenyl)-3 -(1-cyclopentyl-5-oxopyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-[1-(2-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(4- chlorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1 -(4-chlorophenyl)-3-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(4-chlorophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl )urea, 1-(4-acetylphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)urea, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea, 1-(5-chloro-2-methylphenyl)-3 -[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl ]urea, 1-(4-fluorophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(5-chloro-2-methylphenyl)-3-[1-(3-chlorophenyl) -5-oxopyrrolidin-3-yl]urea, 1-(6-chloropyridin-3-yl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(6-chloropyridine -3-yl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1-(2-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-( 6-chloropyridin-3-yl)urea, 1-(4-chlorophenyl)-3-[1-(2-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(4-chlorophenyl)-3-[ 1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-( 2-chlorophenyl)-3-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(4-acetylphenyl)-3-[1-(4-chlorophenyl)-5-oxopyrrolidin- 3 -yl]harn substance, 1-(5-chloro-2-methylphenyl)-3-[1-(2-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2,5-dimethylphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)urea, 1-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea, 1-[1-(2-chlorophenyl). )-5-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea, 1-(4-acetylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1 -[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(6-methylpyridin-2-yl)urea, 1-(6-chloropyridin-3-yl)-3-(5-oxo -1-phenylpyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl). )-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(6-chloropyridin- 3-yl)urea, 1-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(6-chloropyridin-3-yl)urea, 1-(4-chlorophenyl)-3-( 4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(6-methylpyridin-2-yl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-( 4-fluorophenyl)-3-[1-(4-meth oxyphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-[1-(4- methylphenyl)-5-oxopyrrolidin-3-yl]-3-(6-methylpyridin-2-yl)urea, 1-(4-chlorophenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]urea, 1-(5-chloro-2-methylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-oxo-1-phenylpyrrolidin-3- yl)-3-pyridin-2-ylurea, 1-(2-chlorophenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1-(4-chlorophenyl) -5-oxopyrrolidin-3-yl]-3-(2,5-difluorophenyl)urea, 1-(2,5-difluorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl] urea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)urea, 4-[4-[3-(2-chlorophenyl)-2,4,5 -trioxoimidazolidin-1-yl]-2-oxopyrrolidin-1-yl]benzonitrile, 1-(2-fluorophenyl)-3-[1-(4-fluorophenyl)-4-methyl-5-oxopyrrolidin-3-yl]urea , 1-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorophenyl)urea, 1-(2,5-dichlorophenyl)-3-[1-(4- methylphenyl)-5- oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)imidazolidine-2,4,5-trione, 1-(5- chloro-2-methylphenyl)-3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)urea, 1-(5-chloro-2-methylphenyl)-3-[1-(3-cyanophenyl) -5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-fluorophenyl )-3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl) urea, 1-(2-chlorophenyl)-3-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2,5-difluorophenyl)-3-(5-oxo- 1-quinolin-8-ylpyrrolidin-3-yl)urea, 1-(2,5-difluorophenyl)-3-[1-(3,5- difluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2,5-difluorophenyl)-3-[1-(4-fluorophenyl)-4-methyl-5-oxopyrrolidin-3-yl]urea, 1- (2-fluorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]imidazolidine-2,4,5-trione, 1-(2-chlorophenyl)-3-[1-(2 -fluorophenyl)-5-oxopyrrolidin-3-yl]imidazolidine-2,4,5-trione, 1-(2-chlorophenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)imidazolidine -2,4,5-trione, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)imidazolidine-2,4,5-trione, 3-[4 -[3-(2-chlorophenyl)-2,4,5-trioxoimidazolidin-1-yl]-2-oxopyrrolidin-1-yl]benzonitrile, 1-[1-(3,5-difluorophenyl)-5-oxopyrrolidin- 3-yl]-3-(2-fluorophenyl)imidazolidine-2,4,5-trione, 1-(5-chloro-2-methylphenyl)-3-[1-(3,5-difluorophenyl)-5-oxopyrrolidine -3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-[1-(4-fluorophenyl)-4-methyl-5-oxopyrrolidin-3-yl]urea, 1-(2,3 -dichlorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-fluorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3- yl]urea, 1-(2,6-di fluorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]-3-(2 -methylphenyl)urea, 1-(2-chlorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-[1-(4- fluorophenyl)-4-methyl-5-oxopyrrolidin-3-yl]urea, 1-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)urea, 1- (2-chlorophenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-fluorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin- 3-yl]urea, 1-(2-fluorophenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-(1-cyclopentyl- 5-oxopyrrolidin-3-yl)urea, 1-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)urea, 1-(2-chlorophenyl)-3-[ 1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-( 2,5-difluorophenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]-3- (2.6-dic chlorophenyl)urea, 1-(5-chloro-2-methylphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]urea, 1-(1-cyclopentyl-5-oxopyrrolidin-3- yl)-3-(2,5-difluorophenyl)urea, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-fluorophenyl)urea, 1-(2,5-difluorophenyl)-3 -(1-isopropyl-5-oxopyrrolidin-3-yl)urea, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-methylphenyl)urea, 1-(1-cyclopropyl-5- oxopyrrolidin-3-yl)-3-(2,5-difluorophenyl)urea, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2,5-difluorophenyl)urea, 1-(2- fluorophenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-methylphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl ]urea, 1-(2,5-difluorophenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-(1-cyclobutyl-5 -oxopyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-(1-isopropyl-5-oxopyrrolidine -3-yl)urea, 1-(1-cyclopropyl-5-oxopyrrolidin-3-yl)-3-(2-fluorophenyl)urea, 1-(2-fluorophenyl)-3-(1-isopropyl-5-oxopyrrolidine -3-yl)urea, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2-fluorophenyl)urea, 1-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl ]-3-(2,5-difluorophenyl)urea, 1-(2,5-difluorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1-( 2-fluorophenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl)urea, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl) urea, 1-(5-chloro-2-methylphenyl)-3-[1-(4- fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1 -(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-difluorophenyl)urea, 1-(2,6-difluorophenyl)-3-[1-(4-fluorophenyl)-5- oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)urea, 1-(4-chlorophenyl)-3-[1- (2-methylpropyl)-5-oxopyrrolidin-3-yl]urea, 1-(4-chlorophenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3-yl)urea, 1-(5-chloro-2- methylphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3-yl)urea, 1-(5-chloro-2-methylphenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3-yl)urea, 1 -(5-chloro-2-methylphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)urea, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]-3- (2-fluorophenyl)urea, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)urea, 1-(2,5-dichlorophenyl)-3-[1 -(4-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chloropyridin-4-yl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidi n-3-yl]urea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-pyridazin-4-ylurea, 1-(4-fluorophenyl)-3-(5-oxo -1-quinolin-8-ylpyrrolidin-3-yl)urea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-[2-(trifluoromethyl)phenyl]urea, 1-( 5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)-3-[2-(trifluoromethyl)phenyl]urea, 1-(2-cyanophenyl)-3-(5-oxo-1-quinoline-8- ylpyrrolidin-3-yl)urea, 1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]-3-[2-(trifluoromethyl)phenyl]urea, 1-(2-chloropyridin-4-yl )-3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)urea, 1-(5-oxo-1-phenylpyrrolidin-3-yl)-3-[2-(trifluoromethyl)phenyl]urea , 1-(4-fluorophenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)- 3-phenylurea, 1-(2-chloropyridin-4-yl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1-(4-cyanophenyl)-5- oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea, 1-(2-cyanophenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2- cyanophenyl)-3-[1 -(4-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chloropyridin-4-yl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(2 -cyanophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(1-isopropyl-5-oxopyrrolidin-3-yl)-3-phenylurea.1-(4-fluorophenyl)-3 -(1-isopropyl-5-oxopyrrolidin-3-yl)urea., 1-(2-cyanophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)urea, 1-(1-isopropyl-5 - oxopyrrolidin-3-yl)-3-[2-(trifluoromethyl)phenyl]urea, 1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]-3-pyridazin-4-ylurea, 1- (5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)-3-pyridazin-4-ylurea, 1-(5-oxo-1-phenylpyrrolidin-3-yl)-3-pyridazin-4-ylurea, 1-(1-isopropyl-5-oxopyrrolidin-3-yl)-3-pyridazin-4-ylurea, 1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]-3-phenylurea, 1- (2,5-dichlorophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)thiourea, 1-(2,5-dichlorophenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin- 3-yl]thiourea, 1-(2,5-dichlorophenyl)-3-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]thiourea substance, 1-(2,5-dichlorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,4-dichlorophenyl)-3-[1-(3 ,5-difluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(5-chloro-2-methylphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1 -(5-chloro-2-methylphenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,4-dichlorophenyl)-3-[1-(4- fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(5-chloro-2-methylphenyl)-3-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1- (5-chloro-2-methylphenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl] -3-(2,5-dichlorophenyl)thiourea, 1-(5-chloro-2- methylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)thiourea, 1-(2,4-dichlorophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)thiourea, 1-( 2,4-dichlorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,5-dichlorophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3 -yl)thiourea, 1-(2,5-dichlorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,5-dichlorophenyl)-3-[1 -(2-methylpropyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,5-dichlorophenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]thiourea, 1- (2,5-dichlorophenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2, 5-dichlorophenyl)thiourea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorophenyl)thiourea, 1-(5-chloro-2-methylphenyl)-3 - (1-cyclopropyl-5-oxopyrrolidin-3-yl)thiourea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,4-dichlorophenyl)thiourea, 1-( 2-chlorophenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)thiourea, 1- (2,5-dichlorophenyl)-3-[1-(3,5-difluorophenyl)-4-methyl-5-oxopyrrolidin-3-yl]thiourea, 1-(2-chlorophenyl)-3-[1-(4 -methylphenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2-chlorophenyl)-3-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2-chlorophenyl) -3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(5-chloro-2-methylphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)thiourea , 1-(2-chlorophenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2 ,5-dichlorophenyl)thiourea, 1-(2-chlorophenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3-yl)thiourea, 1-(5-chloro-2-methylphenyl)-3-[1-( 4-cyanophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,4-dichlorophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)thiourea, 1-(5-chloro-2 -methylphenyl)-3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)thiourea A very specifically preferred subject of the invention is the use of the following compounds described by the general formula (I). ments: 4-[2-[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]oxyethoxy]benzoic acid, Methyl-(2S)-2-[[2-[( 2S)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-(1H-imidazol-4-yl)propionate, 2-(4-formylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, (2R)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin- 2-yl]acetyl]amino]-4-methylsulfanylbutyric acid, 2-[(2S)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, 2-(4-ethylphenoxy) ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 1-[(2,3-difluorophenyl)methyl]-5-(2-oxo-2-pyrrolidin-1 -ylethyl)pyrrolidin-2-one, 2-(4-methylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-[1-[(2, 3-Difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(quinolin-5-ylmethyl)acetamide, N -Benzyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2 -yl]acetamide, methyl 3-[[2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionate, 2-[1-[(2,3 -difluorophenyl) m ethyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamide, butan-2-yl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, (2S)-3-(1H-Indol-3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionic acid, 2- [1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(1H-indol-3-yl)ethyl]acetamide, N-butan-2-yl-2 - [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, (2R)-4-methyl-2-[[2-[(2R)-1-[(4-methylphenyl)methyl ]-5-oxopyrrolidin-2-yl]acetyl]amino]pentanecarboxylic acid, 2-[(2R)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamide, ( 2S)-2-[[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, (2R)-1-[2-[1- [(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]pyrrolidin-2-carboxylic acid, 2-[1-[(4-cyanophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid, ( 2S)-2-[[2-[(2S)-1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, methyl 2-[[2-[ 1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]benzoates, N -cyclopropyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl ]acetamide, N-(Isoquinolin-5-ylmethyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-[2-(2-Bromophenyl)ethyl]- 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, (2R)-3-(1H-indol-3-yl)-2-[[2-[1-[ (4-methylphenyl)meth yl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionic acid, N -[2-(1H-indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamide, methyl 2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]methylamino]acetate, 2-[1-[(4 -methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(quinolin-6-ylmethyl)acetamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-[ 1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[(1-ethyl-1H-pyrazol-3-yl)methyl]-2-[1-[(4-methylphenyl )methyl]-5-oxopyrrolidin-2-yl]acetamide, N -[2-(diethylamino)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, ( 2S,3S)-3-Methyl-2-[[2-[(2S)-1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]pentanecarboxylic acid, 2-[[2 -[(2S)-1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]methylamino]acetic acid, N -Methylsulfonyl-2-[5-oxo-3-phenyl-1 -(pyridin-3-ylmethyl)pyrrolidin-2-yl]acetamide, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]propionic acid, methyl (2S)-3-(1H- imidazol-4-yl)-2-[[2-[( 2R)-1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionate, 2-[1-[(2,3-Difluorophenyl)methyl]-5-oxopyrrolidin-2- yl]-N-[2-(2-methoxyphenyl)ethyl]acetamide, 2-[1-[(4-fluorophenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]acetic acid, 2-[1- [(3-Fluorophenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]acetic acid, Methyl 2-[1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionate , 2-(1-Benzyl-5-oxo-3-phenylpyrrolidin-2-yl)acetic acid, N -[2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl]-2-[1 -[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-[2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl]-2-[1-[ (2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 1-cyclopentyl-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidin-3-carboxamide, 1-(4-chlorophenyl) -N-[(6-chloropyridin-3-yl)methyl]-5-oxopyrrolidine-3-carboxamide, 1-cyclobutyl-5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidin-3-carboxamide, N-[ (5-Chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-5-oxopyrrolidine-3-carboxamide, N -[(2,4-Dichlorophenyl)me thyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide, 1-cyclopentyl-N-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide, N-[1-( 4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorophenyl)acetamide, 2-(2,5-dichlorophenyl)-N-[1-(4-methoxyphenyl)-5-oxopyrrolidin- 3-yl]acetamide, N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorophenyl)acetamide, 2-(2,5-dichlorophenyl)-N-(1-isopropyl- 5-oxopyrrolidin-3-yl)acetamide, 2-(2,5-dimethylphenyl)-N-(1-isopropyl- 5-oxopyrrolidin-3-yl)acetamide, N-(1-Isopropyl-5-oxopyrrolidin-3-yl)-2-(2-methylphenyl)acetamide, 2-(2-chlorophenyl)-N-(1-cyclobutyl- 5-oxopyrrolidin-3-yl)acetamide, 1-(5-chloro-2-methylphenyl)-3-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro- 2-methylphenyl)-3-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(6-chloropyridin-3-yl)-3-[1-(4-methylphenyl)-5 -oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(4-chlorophenyl)- 3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(5-chloro-2-methylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(5-Chloro-2-methylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-Chlorophenyl)-3-[1-(4-methoxyphenyl). )-5-oxopyrrolidin-3-yl]urea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)urea, 1-(5-chloro-2- methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl ]urine Substance, 1-(2-Fluorophenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(2-Chlorophenyl)-3-(1-isopropyl-5-oxopyrrolidin- 3-yl)urea, 1-(5-chloro-2-methylphenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl) -3-(1-cyclobutyl-5-oxopyrrolidin-3-yl)urea, 1-(2,5-dichlorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1 -[1-(4-Cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorophenyl)thiourea, 1-(2-Chlorophenyl)-3-[1-(4-methoxyphenyl)-5 -oxopyrrolidin-3-yl]thiourea. Some of the aforementioned substituted pyrrolidinones of the general formula (I) are also not yet known in the prior art. Thus, as a further part of the invention, substituted N-pyrrolidinones of the general formula (I) or their salts apply,
Figure imgf000052_0001
wherein R1 for (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, (C1-C10)-haloalkyl, (C3-C10)-cycloalkyl, (C3-C10)-halocycloalkyl, (C4-C10)-cycloalkenyl, aryl, aryl-(C1-C8th)-alkyl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, heterocyclyl, heterocyclyl-(C1-C8th)-alkyl, R32O-(C1-C8th)-alkyl, (C3-C10)-cycloalkyl-(C1-C8th)-alkyl represents hydrogen, R7 stands for one of the following groups G-4 to G-6, where an arrow stands for a bond to the pyrrolidinone ring in the general formula (I),
Figure imgf000053_0001
R3, R4 independently for hydrogen, (C1-C8th)-alkyl, (C1-C10)-haloalkyl, (C3-C10)-cycloalkyl, (C3-C10)-cycloalkyl-(C1-C8th)-alkyl, OR32 stand, r5, R6 independently for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C1-C10)-haloalkyl, (C3-C10)-cycloalkyl, aryl-(C1-C8th)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, heterocyclyl, heterocyclyl-(C1-C8th)-alkyl, R32O-(C1-C8th)-alkyl, R30R31N-(C1-C8th)-alkyl, NO30R31, OR32, (C3-C10)-cycloalkyl-(C1-C8th)-alkyl, R8th, R9, R10 independently for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, aryl-(C1-C8th)-alkyl, heteroaryl-(C1-C8th)-alkyl, C(O=)R32, (C1-C8th)-alkyloxycarbonyl, aryl-(C1-C8th)-alkyloxycarbonyl, R11, R12 independently for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, (C1-C10)-haloalkyl, (C3-C10)-cycloalkyl, aryl-(C1-C8th)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, heterocyclyl, heterocyclyl-(C1-C8th)-alkyl, R32O-(C1-C8th)-alkyl, R30R31N-(C1-C8th)-alkyl, (C3-C10)-cycloalkyl-(C1-C8th)-alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C8th)-alkyl, R30R31N(O)C-(C1-C8th)-alkyl, OR32 stand, r30 and R31 independently for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, (C1-C8th)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C8th)-haloalkenyl, (C3-C8th)-haloalkynyl, (C3-C10)-cycloalkyl, (C3-C10)-halocycloalkyl, (C4-C10)-cycloalkenyl, (C4-C10)-halocycloalkenyl, (C1-C8th)-alkoxy-(C1-C8th)-alkyl, (C1-C8th)-haloalkoxy-(C1-C8th)-alkyl, (C1-C8th)-alkylthio-(C1-C8th)-alkyl, (C1-C8th)-haloalkylthio-(C1-C8th)-alkyl, (C1-C8th)-alkoxy-(C1-C8th)-haloalkyl, aryl, aryl-(C1-C8th)-alkyl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, (C3-C8th)-cycloalkyl-(C1-C8th)-alkyl, (C4-C10)-cycloalkenyl-(C1-C8th)-alkyl, COR32, SO2R33, heterocyclyl, (C1-C8th)-alkoxycarbonyl, bis[(C1- C8th)-alkyl]aminocarbonyl-(C1-C8th)-alkyl, (C1-C8th)-alkyl-aminocarbonyl-(C1-C8th)-alkyl, aryl-(C1- C8th)-alkyl-aminocarbonyl-(C1-C8th)-alkyl, aryl-(C1-C8th)-alkoxycarbonyl, heteroaryl-(C1-C8th)- alkoxycarbonyl, (C2-C8th)-alkenyloxycarbonyl, (C2-C8th)-alkynyloxycarbonyl, (C1-C8th)- alkoxycarbonyl-(C1-C8th)-alkyl, (C2-C8th)-alkenyloxycarbonyl-(C1-C8th)-alkyl, (C2-C8th)- alkynyloxycarbonyl-(C1-C8th)-alkyl, aryl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl, heteroaryl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl, heterocyclyl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl, heterocyclyl-(C1-C8th)-alkyl, or R30 and R31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R32 for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, (C1-C8th)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C8th)-haloalkenyl, (C3-C8th)-haloalkynyl, (C3-C10)-cycloalkyl, (C3-C10)-halocycloalkyl, (C4-C10)-cycloalkenyl, (C4-C10)-halocycloalkenyl, (C1-C8th)-alkoxy-(C1-C8th)-alkyl, (C1-C8th)-haloalkoxy-(C1-C8th)-alkyl, (C1-C8th)-alkoxy-(C1-C8th)-haloalkyl, (C1-C8th)-alkoxy- (C1-C8th)-alkoxy-(C1-C8th)-alkyl, (C1-C8th)-alkoxy-(C1-C8th)-alkoxy-(C1-C8th)-alkoxy-(C1-C8th)-alkyl, (C1-C8th)-alkoxy-(C1-C8th)-alkoxy-(C1-C8th)-alkoxy-(C1-C8th)-alkoxy-(C1-C8th)-alkyl, aryl, aryl-(C1-C8th)-alkyl, aryl-(C1-C8th)-alkoxy-(C1-C8th)-alkyl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, (C3-C8th)-cycloalkyl-(C1-C8th)-alkyl, (C4-C10)-cycloalkenyl-(C1-C8th)-alkyl, bis-[(C1-C8th)-alkyl]aminocarbonyl-(C1-C8th)-alkyl, (C1-C8th)-alkylaminocarbonyl-(C1-C8th)-alkyl, aryl-(C1-C8th)-alkylaminocarbonyl-(C1-C8th)-alkyl, bis-[(C1-C8th)-alkyl]amino-(C2-C6)-alkyl, (C1-C8th)-alkylamino-(C2-C6)-alkyl, aryl-(C1-C8th)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C8th)-alkyl, hydroxycarbonyl-(C1-C8th)-alkyl, heterocyclyl, heterocyclyl-(C1-C8th)-alkyl, tris-[(C1-C8th)-alkyl]silyl-(C1-C8th)-alkyl, bis-[(C1-C8th)-alkyl](aryl)silyl(C1-C8th)-alkyl, [(C1-C8th)-alkyl]-bis-(aryl)silyl-(C1-C8th)-alkyl, (C1-C8th)-alkylcarbonyloxy-(C1-C8th)-alkyl, (C3-C8th)-cycloalkylcarbonyloxy-(C1-C8th)-alkyl, arylcarbonyloxy-(C1-C8th)-alkyl, heteroarylcarbonyloxy-(C1-C8th)-alkyl, heterocyclylcarbonyloxy-(C1-C8th)-alkyl, aryloxy-(C1-C8th)-alkyl, heteroaryloxy- (C1-C8th)-alkyl, heterocyclyloxy-(C1-C8th)-alkyl, (C1-C8th)-alkoxycarbonyl, (C1-C8th)- alkoxycarbonyl-(C1-C8th)-alkyl, (C2-C8th)-alkenyloxycarbonyl-(C1-C8th)-alkyl, (C2-C8th)- alkynyloxycarbonyl-(C1-C8th)-alkyl, aryl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl, heteroaryl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl, heterocyclyl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl, R33 for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, (C1-C8th)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C8th)-haloalkenyl, (C3-C8th)-haloalkynyl, (C3-C10)-cycloalkyl, (C3-C10)-halocycloalkyl, (C4-C10)-cycloalkenyl, (C4-C10)-halocycloalkenyl, (C1-C8th)-alkoxy-(C1-C8th)-alkyl, (C1-C8th)-alkoxy-(C1-C8th)-haloalkyl, aryl, aryl-(C1-C8th)-alkyl, heteroaryl, heteroaryl (C1-C8th)-alkyl, heterocyclyl-(C1-C8th)-alkyl, (C3-C8th)-cycloalkyl-(C1-C8th)-alkyl, (C4-C10)-cycloalkenyl-(C1-C8th)-alkyl, bis-[(C1-C8th)-alkyl]amino, (C1-C8th)-alkyl-amino, aryl-(C1-C8th)-amino, aryl-(C1-C6)-alkyl-amino, aryl-[(C1-C8th)-alkyl]amino; heteroaryl-(C1-C8th)-amino, heteroaryl-(C1-C6)-alkyl-amino, heteroaryl-[(C1-C8th)-alkyl]amino; heterocyclyl-(C1-C8th)-amino, heterocyclyl-(C1-C6)-alkyl-amino, heterocyclyl-[(C1-C8th)-alkyl]amino; (C3-C8th)-cycloalkylamino, (C3-C8th)-cycloalkyl-[(C1-C8th)-alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R37 for phenyl, 2-fluorophenyl, 4-fluorophenyl, 4-bromo-3-methylphenyl, 2-chlorophenyl, 4-chlorophenyl, 4-acetylphenyl, 5-chloro-2-methylphenyl, 2-chloro-5-methylphenyl, 6-chloropyridine -3-yl, 2,5-dimethylphenyl, 2,5-difluorophenyl, 2,5-dichlorophenyl, 6-methylpyridin-2-yl, pyridin-2-yl, 2,3-dichlorophenyl, 2,6-difluorophenyl, 2 -Methylphenyl, 2,6-dichlorophenyl, 2-chloropyridin-4-yl, pyridazin-4-yl, 2-(trifluoromethyl)phenyl, 2-cyanophenyl, 2-bromophenyl, 2-iodophenyl, 5-fluoro-2-methylphenyl, and is 0,1,2. Preference is given to compounds of the general formula (I) in which R1 for (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C1-C10)-haloalkyl, (C3-C10)-cycloalkyl, (C3-C7)-halocycloalkyl, (C4-C7)-cycloalkenyl, aryl, aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, R32O-(C1-C7)-alkyl, (C3-C10)-cycloalkyl-(C1-C7)-alkyl, R2 is hydrogen, R7 stands for one of the following groups G-4 to G-6, where an arrow stands for a bond to the pyrrolidinone ring in the general formula (I),
Figure imgf000056_0001
R3, R4 independently for hydrogen, (C1-C7)-alkyl, (C1-C7)-haloalkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, OR32 stand, r5, R6 independently for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C1-C7)-haloalkyl, (C3-C7)-cycloalkyl, aryl-(C1-C7)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, R32O-(C1-C7)-alkyl, R30R31N-(C1-C7)-alkyl, NO30R31, OR32, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, R8th, R9, R10 independently for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, aryl-(C1-C7)-alkyl, heteroaryl-(C1-C7)-alkyl, C(O=)R32, (C1-C7)-alkyloxycarbonyl, aryl-(C1-C7)-alkyloxycarbonyl, R11, R12 independently for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C1-C7)-haloalkyl, (C3-C7)-cycloalkyl, aryl-(C1-C7)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, R32O-(C1-C7)-alkyl, R30R31N-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C7)-alkyl, R30R31N(O)C-(C1-C7)-alkyl, OR32 stand, r30 and R31 independently for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C1-C7)-cyanoalkyl, (C1-C7)-haloalkyl, (C2-C7)-haloalkenyl, (C3-C7)-haloalkynyl, (C3-C7)-cycloalkyl, (C3-C7)-halocycloalkyl, (C4-C7)-cycloalkenyl, (C4-C7)-halocycloalkenyl, (C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-haloalkoxy-(C1-C7)-alkyl, (C1-C7)-alkylthio-(C1-C7)-alkyl, (C1-C7)-haloalkylthio-(C1-C7)-alkyl, (C1-C7)-alkoxy-(C1-C7)-haloalkyl, aryl, aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, (C4-C7)-cycloalkenyl-(C1-C7)-alkyl, COR32, SO2R33, heterocyclyl, (C1-C7)-alkoxycarbonyl, bis[(C1- C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-alkylaminocarbonyl-(C1-C7)-alkyl, aryl-(C1- C7)-alkylaminocarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxycarbonyl, heteroaryl-(C1-C7)-alkoxycarbonyl, (C2-C7)-alkenyloxycarbonyl, (C2-C7)-alkynyloxycarbonyl, (C1-C7)- alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)- alkynyloxycarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, heteroaryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkyl, or R30 and R31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R32 for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C1-C7)-cyanoalkyl, (C1-C7)-haloalkyl, (C2-C7)-haloalkenyl, (C3-C7)-haloalkynyl, (C3-C7)-cycloalkyl, (C3-C10)-halocycloalkyl, (C4-C7)-cycloalkenyl, (C4-C7)-halocycloalkenyl, (C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-haloalkoxy-(C1-C7)-alkyl, (C1-C7)-alkoxy-(C1-C7)-haloalkyl, (C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, aryl, aryl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxy-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, (C4-C7)-cycloalkenyl-(C1-C7)-alkyl, bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, bis-[(C1-C7)-alkyl]amino-(C2-C6)-alkyl, (C1-C7)-alkyl-amino-(C2-C6)-alkyl, aryl-(C1-C7)-alkylamino-(C2-C6)-alkyl, R33(O)mS-(C1-C7)-alkyl, hydroxycarbonyl-(C1-C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, tris-[(C1-C7)-alkyl]silyl-(C1-C7)-alkyl, bis-[(C1-C7)-alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-alkyl]-bis(aryl)silyl-(C1-C7)-alkyl, (C1-C7)-alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-cycloalkylcarbonyloxy-(C1-C7)-alkyl, arylcarbonyloxy-(C1-C7)-alkyl, heteroarylcarbonyloxy-(C1-C7)-alkyl, heterocyclylcarbonyloxy-(C1-C7)-alkyl, aryloxy-(C1-C7)-alkyl, heteroaryloxy-(C1-C7)-alkyl, heterocyclyloxy-(C1-C7)-alkyl, (C1-C7)-alkoxycarbonyl, (C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)-alkynyloxycarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, heteroaryl-(C1-C7)-alkoxycarbonyl- (C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, R33 for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C1-C7)-cyanoalkyl, (C1-C7)-haloalkyl, (C2-C7)-haloalkenyl, (C3-C7)-haloalkynyl, (C3-C7)-cycloalkyl, (C3-C7)-halocycloalkyl, (C4-C7)-cycloalkenyl, (C4-C7)-halocycloalkenyl, (C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-alkoxy-(C1-C7)-haloalkyl, aryl, aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, (C4-C10)-cycloalkenyl-(C1-C7)-alkyl, bis-[(C1-C7)-alkyl]amino, (C1-C7)-alkyl-amino, aryl-(C1-C7)-amino, aryl-(C1- C6)-alkyl-amino, aryl-[(C1-C7)-alkyl]amino; heteroaryl-(C1-C7)-amino, heteroaryl-(C1-C6)-alkyl-amino, heteroaryl-[(C1-C7)-alkyl]amino; heterocyclyl-(C1-C7)-amino, heterocyclyl-(C1- C6)-alkyl-amino, heterocyclyl-[(C1-C7)-alkyl]amino; (C3-C7)-cycloalkyl-amino, (C3-C7)-cycloalkyl-[(C1-C7)-alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R37 for phenyl, 2-fluorophenyl, 4-fluorophenyl, 4-bromo-3-methylphenyl, 2-chlorophenyl, 4-chlorophenyl, 4-acetylphenyl, 5-chloro-2-methylphenyl, 2-chloro-5-methylphenyl, 6-chloropyridine -3-yl, 2,5-dimethylphenyl, 2,5-difluorophenyl, 2,5-dichlorophenyl, 6-methylpyridin-2-yl, pyridin-2-yl, 2,3-dichlorophenyl, 2,6-difluorophenyl, 2 -methylphenyl, 2,6-dichlorophenyl, 2-chloropyridin-4-yl, pyridazin-4-yl, 2-(trifluoromethyl)phenyl, 2-cyanophenyl and m is 0,1,2. Particularly preferred are compounds of the general formula (I) in which R1 for (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C10)-haloalkyl, (C3-C10)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, (C3-C10)-cycloalkyl-(C1-C6)-alkyl, R2 is hydrogen, R7 stands for one of the following groups G-4 to G-6, where an arrow stands for a bond to the pyrrolidinone ring in the general formula (I),
Figure imgf000058_0001
R3, R4 independently for hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, OR32 stand, r5, R6 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, NO30R31, OR32, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, R8th, R9, R10 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkyl, C(O=)R32, (C1-C6)-alkyloxycarbonyl, aryl-(C1-C6)-alkyloxycarbonyl, R11, R12 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, OR32 stand, r30 and R31 are the same or different and are independently hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-haloalkoxy-(C1-C6)-alkyl, (C1-C6)-alkylthio-(C1-C6)-alkyl, (C1-C6)-haloalkylthio-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C6)-cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, heterocyclyl, (C1-C6)-alkoxycarbonyl, bis[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkylaminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-alkenyloxycarbonyl, (C2-C6)- Aalkynyloxycarbonyl, (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)- alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkynyloxycarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, or R30 and R31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R32 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C10)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-haloalkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, aryl, aryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C6)-cycloalkenyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-alkyl-amino-(C2-C6)-alkyl, aryl-(C1-C6)-alkylamino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, hydroxycarbonyl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, tris-[(C1-C6)-alkyl]silyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-alkyl]-bis(aryl)silyl-(C1-C6)-alkyl, (C1-C6)-alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-cycloalkylcarbonyloxy-(C1-C6)-alkyl, arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, aryloxy-(C1-C6)-alkyl, heteroaryloxy-(C1-C6)-alkyl, heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkynyloxycarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, R33 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C6)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C10)-cycloalkenyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]amino, (C1-C6)-alkyl-amino, aryl-(C1-C6)-amino, aryl-(C1- C6)-alkyl-amino, aryl-[(C1-C6)-alkyl]amino; heteroaryl-(C1-C6)-amino, heteroaryl-(C1-C6)-alkyl-amino, heteroaryl-[(C1-C6)-alkyl]amino; heterocyclyl-(C1-C6)-amino, heterocyclyl-(C1- C6)-alkyl-amino, heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-cycloalkyl-amino, (C3-C6)-cycloalkyl-[(C1-C6)-alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R37 for phenyl, 12-fluorophenyl, 4-fluorophenyl, 4-bromo-3-methylphenyl, 2-chlorophenyl, 4-chlorophenyl, 4-acetylphenyl, 5-chloro-2-methylphenyl, 2-chloro-5-methylphenyl, 6-chloropyridine -3-yl, 2,5-dimethylphenyl, 2,5-difluorophenyl, 2,5-dichlorophenyl, 6-methylpyridin-2-yl, pyridin-2-yl, 2,3-dichlorophenyl, 2,6-difluorophenyl, 2 -methylphenyl, 2,6-dichlorophenyl, 2-chloropyridin-4-yl, pyridazin-4-yl, 2-(trifluoromethyl)phenyl, 2-cyanophenyl and m is 0, 1, 2. The following compounds of the general formula (I) are very particularly preferred: N-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorophenyl)acetamide, 2-(2,5 -dichlorophenyl)-N-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]acetamide, 2-(2,5-dichlorophenyl)-N-[1-(3,5-difluorophenyl)-5- oxopyrrolidin-3-yl]acetamide, 2-(2,5-dimethylphenyl)-N-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)acetamide, N -[1-(4-cyanophenyl)- 5-oxopyrrolidin-3-yl]-2-(2,5-dichlorophenyl)acetamide, 2-(2,5-dichlorophenyl)-N-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]acetamide , 2-(2,5-dichlorophenyl)-N-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamide, 2-(2,5-dichlorophenyl)-N-[1-(4- methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamide, 2-(2-chlorophenyl)-N-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]acetamide, N-[1-(4- chlorophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorophenyl)acetamide, 2-(2,5-dichlorophenyl)-N-[1-(3,5-difluorophenyl)-4-methyl- 5-oxopyrrolidin-3-yl]acetamide, 2-(2-chlorophenyl)-N-[1-(3,5-difluorophenyl)-4-methyl-5-oxopyrrolidin-3-yl]acetamide , 2-(2,5-dichlorophenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acetamide, 2-(2,5-dichlorophenyl)-N-[1-(2-fluorophenyl)-5 -oxopyrrolidin-3-yl]acetamide, 2-(2,5-dichlorophenyl)-N-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)acetamide, N-[1-(3,5- difluorophenyl)-5-oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamide, N -[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamide, N -[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylphenyl)acetamide, N -[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl] -2-(2-methylphenyl)acetamide, N-(1-cyclopropyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorophenyl)acetamide, 2-(2-chlorophenyl)-N-[1- (4-methylphenyl)-5-oxopyrrolidin-3-yl]acetamide, N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorophenyl)acetamide, 2-(2-methylphenyl) -N-(5-oxo-1-phenylpyrrolidin-3-yl)acetamide, 2-(2-chlorophenyl)-N-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]acetamide, N-[ 1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylphenyl)acetamide, 2-(2,5-dimethylphenyl)-N-[1-(4-fluorophenyl) -5-oxopyrrolidin-3-yl ]acetamide, 2-(2,5-dimethylphenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acetamide, N-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]- 2-(2-methylphenyl)acetamide, 2-(2,5-dimethylphenyl)-N-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]acetamide, 2-(2,5-dichlorophenyl)- N-(1-isopropyl-5-oxopyrrolidin-3-yl)acetamide, N-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylphenyl)acetamide, 2- (2-chlorophenyl)-N-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamide, 2-(2,5-dimethylphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3- yl)acetamide, N-(1-isopropyl-5-oxopyrrolidin-3-yl)-2-(2-methylphenyl)acetamide, 2-(2,5-dichlorophenyl)-N-[1-(2-methylpropyl)- 5-oxopyrrolidin-3-yl]acetamide, 2-(2-chlorophenyl)-N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)acetamide, 2-(2-chlorophenyl)-N-[2-(2 -chlorophenyl)acetyl]-N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)acetamide, 2-(4-chlorophenyl)-N-[2-(4-chlorophenyl)acetyl]-N-[1-( 2-methylpropyl)-5-oxopyrrolidin-3-yl]acetamide, 1-(4-fluorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(4-bromo -3-me ethylphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-[1-(2-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1 -(4-chlorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-(5-oxo-1-phenylpyrrolidin- 3-yl)urea, 1-(4-chlorophenyl)-3-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(4-chlorophenyl)-3-(5-oxo- 1-phenylpyrrolidin-3-yl)urea, 1-(4-acetylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin- 3-yl]-3-(4-fluorophenyl)urea, 1-(5-chloro-2-methylphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]urea, 1-( 5-chloro-2-methylphenyl)-3-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(4-fluorophenyl)-3-(5-oxo-1-phenylpyrrolidin-3 -yl)urea, 1-(5-chloro-2-methylphenyl)-3-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(6-chloropyridin-3-yl)- 3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(6-chloropyridin-3-yl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]urea, 1-[1-(2-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(6-chloropyridin-3-yl)urea, 1-(4-chlorophenyl)-3-[1- (2-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(4-chlorophenyl)-3-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2- chlorophenyl)-3-[1-(3-ch lorphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(4-acetylphenyl)- 3-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-[1-(2-chlorophenyl)-5-oxopyrrolidin-3- yl]urea, 1-(2,5-dimethylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl] -3-(4-fluorophenyl)urea, 1-[1-(2-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea, 1-(4-acetylphenyl)-3-[ 1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(6-methylpyridin-2-yl)urea , 1-(6-chloropyridin-3-yl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-[1-(4-methylphenyl)-5 -oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-[1-(4- chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(6-chloropyridin-3-yl)urea, 1-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(6- chloropyridin-3-yl)ha urea, 1-(4-chlorophenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(6-methylpyridin-2-yl)-3-(5-oxo- 1-phenylpyrrolidin-3-yl)urea, 1-(4-fluorophenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl) -3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]-3-(6-methylpyridin-2-yl)urea , 1-(4-chlorophenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-[1-(4- methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-oxo-1-phenylpyrrolidin-3-yl)-3-pyridin-2-ylurea, 1-(2-chlorophenyl)-3-[1- (4-methoxyphenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-difluorophenyl)urea, 1-( 2,5-difluorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3- (2-fluorophenyl)urea, 4-[4-[3-(2-chlorophenyl)-2,4,5-trioxoimidazolidin-1-yl]-2-oxopyrrolidin-1-yl]benzonitrile, 1-(2-fluorophenyl )-3-[1 -(4-fluorophenyl)-4-methyl-5-oxopyrrolidin-3-yl]urea, 1-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorophenyl) urea, 1-(2,5-dichlorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)imidazolidine-2,4,5-trione, 1-(5-chloro-2-methylphenyl)-3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl )urea, 1-(5-chloro-2-methylphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3- [1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-fluorophenyl)-3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)urea, 1- (2-chlorophenyl)-3-(5-oxo-1-quinoline- 8-ylpyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2,5-difluorophenyl) -3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)urea, 1-(2,5-difluorophenyl)-3-[1-(3,5-difluorophenyl)-5-oxopyrrolidine-3 -yl]urea, 1-(2,5-difluorophenyl)-3-[1-(4-fluorophenyl)-4-methyl-5-oxopyrrolidin-3-yl]urea, 1-(2-fluorophenyl)-3- [1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]imidazolidine-2,4,5-trione, 1-(2-chlorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidine- 3-yl]imidazolidine-2,4,5-trione, 1-(2-chlorophenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)imidazolidine-2,4,5-trione , 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)imidazolidine-2,4,5-trione, 3-[4-[3-(2-chlorophenyl )-2,4,5-trioxoimidazolidin-1-yl]-2-oxopyrrolidin-1-yl]benzonitrile, 1-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]-3-( 2-fluorophenyl)imidazolidine-2,4,5-trione, 1-(5-chloro-2-methylphenyl)-3-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1 -(5-chloro-2-methylphenyl)-3-[1-(4-fl fluorophenyl)-4-methyl-5-oxopyrrolidin-3-yl]urea, 1-(2,3-dichlorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1- (2-fluorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2,6-difluorophenyl)-3-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]urea, 1-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl)urea, 1-(2-chlorophenyl)-3-[ 1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-[1-(4-fluorophenyl)-4-methyl-5-oxopyrrolidin-3-yl]urea , 1-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)urea, 1-(2-chlorophenyl)-3-[1-(3-cyanophenyl) -5-oxopyrrolidin-3-yl]urea, 1-(2-fluorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-fluorophenyl)-3- (4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)urea, 1-[1-( 3-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)urea, 1-(2-chlorophenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl] urea, 1-(2-chlorophenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(2,5-difluorophenyl)-3-(4-methyl-5- oxo-1-phenylpyrrolidin-3-yl)urea, 1-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(2,6-dichlorophenyl)urea, 1-(5-chloro- 2-methylphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]urea, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2,5-difluorophenyl )urea, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-fluorophenyl)urea, 1-(2,5-difluorophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3 -yl)urea, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-methylphenyl)urea, 1-(1-cyclopropyl-5-oxopyrrolidin-3-yl)-3-(2 ,5-difluorophenyl)urea, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2,5-difluorophenyl)urea, 1-(2-fluorophenyl)-3-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-methylphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]urea, 1-(2,5-difluorophenyl )-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-(1-cyclobutyl-5-oxopyrr olidin-3-yl)urea, 1-(2-chlorophenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-[1-(2-methylpropyl )-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)urea, 1-(1-cyclopropyl-5-oxopyrrolidin-3- yl)-3-(2-fluorophenyl)urea, 1-(2-fluorophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)urea, 1-(1-cyclopentyl-5-oxopyrrolidin-3- yl)-3-(2-fluorophenyl)urea, 1-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-difluorophenyl)urea, 1-(2,5- difluorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidine-3- yl]urea, 1-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl)urea, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3- yl]-3-(2-methylphenyl)urea, 1-(5-chloro-2-methylphenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5- chloro-2-methylphenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3- (2,5-difluorophenyl)urea, 1-(2,6-difluorophenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl). )-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)urea, 1-(4-chlorophenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]urea, 1- (4-chlorophenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3-yl)urea, 1-(5-chloro-2-methylphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3-yl) urea, 1-(5-chloro-2-methylphenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3-yl)urea, 1-(5-chloro-2-methylphenyl)-3-(1-isopropyl- 5-oxopyrrolidin-3-yl)urea, 1-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)urea, 1-[1-(4-chloro rphenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)urea, 1-(2,5-dichlorophenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl] urea, 1-(2-chloropyridin-4-yl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin- 3-yl]-3-pyridazin-4-ylurea, 1-(4-fluorophenyl)-3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)urea, 1-[1-(4- cyanophenyl)-5-oxopyrrolidin-3-yl]-3-[2-(trifluoromethyl)phenyl]urea, 1-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)-3-[2-( trifluoromethyl)phenyl]urea, 1-(2-cyanophenyl)-3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)urea, 1-[1-(4-fluorophenyl)-5-oxopyrrolidin- 3-yl]-3-[2-(trifluoromethyl)phenyl]urea, 1-(2-chloropyridin-4-yl)-3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)urea, 1-(5-oxo-1-phenylpyrrolidin-3-yl)-3-[2-(trifluoromethyl)phenyl]urea, 1-(4-fluorophenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidine -3-yl]urea, 1-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)-3-phenylurea, 1-(2-chloropyridin-4-yl)-3-[1-(4 -cyanophenyl)-5-o xopyrrolidin-3-yl]urea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea, 1-(2-cyanophenyl)-3-[1- (4-cyanophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-cyanophenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2- chloropyridin-4-yl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(2-cyanophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)urea, 1 -(1-isopropyl-5-oxopyrrolidin-3-yl)-3-phenylurea.1-(4-fluorophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)urea., 1-(2- cyanophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)urea, 1-(1-isopropyl-5-oxopyrrolidin-3-yl)-3-[2-(trifluoromethyl)phenyl]urea, 1- [1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]-3-pyridazin-4-ylurea, 1-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)-3-pyridazin- 4-ylurea, 1-(5-oxo-1-phenylpyrrolidin-3-yl)-3-pyridazin-4-ylurea, 1-(1-isopropyl-5-oxopyrrolidin-3-yl)-3-pyridazin-4- ylurea, 1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]-3-phenylurea, 1-(2,5-dichlorophenyl)-3-(5-oxo- 1-phenylpyrrolidin-3-yl)thiourea, 1-(2,5-dichlorophenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,5-dichlorophenyl) -3-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,5-dichlorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidine-3 -yl]thiourea, 1-(2,4-dichlorophenyl)-3-[1-(3,5-difluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(5-chloro-2-methylphenyl)- 3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(5-chloro-2-methylphenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3- yl]thiourea, 1-(2,4-dichlorophenyl)-3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(5-chloro-2-methylphenyl)-3-[ 1-(3,5-difluorophenyl)-5-oxopyrrolidine-3- yl]thiourea, 1-(5-chloro-2-methylphenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-[1-(4-chlorophenyl)-5- oxopyrrolidin-3-yl]-3-(2,5-dichlorophenyl)thiourea, 1-(5-chloro-2-methylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)thiourea, 1-( 2,4-dichlorophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)thiourea, 1-(2,4-dichlorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidine-3 - yl]thiourea, 1-(2,5-dichlorophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)thiourea, 1-(2,5-dichlorophenyl)-3-[1-(4- methylphenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,5-dichlorophenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,5 -dichlorophenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,5-dichlorophenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidine- 3-yl]thiourea, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2,5-dichlorophenyl)thiourea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3- yl]-3-(2,5-dichlorophenyl)thiourea, 1-(5-chloro-2-methylphenyl)-3-(1-cyclo propyl-5-oxopyrrolidin-3-yl)thiourea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,4-dichlorophenyl)thiourea, 1-(2-chlorophenyl) -3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)thiourea, 1-(2,5-dichlorophenyl)-3-[1-(3,5-difluorophenyl)-4-methyl-5-oxopyrrolidine-3 -yl]thiourea, 1-(2-chlorophenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2-chlorophenyl)-3-[1-(4- chlorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2-chlorophenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(5-chloro-2 -methylphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)thiourea, 1-(2-chlorophenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2,5-dichlorophenyl)thiourea, 1-(2-chlorophenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3-yl) thiourea, 1-(5-chloro-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-(2,4-dichlorophenyl)-3-(1- isopropyl-5-oxopyrrolidin-3-yl)thiourea, 1-(5-chloro-2-methylphe nyl)-3-(5-oxo-1-quinolin-8-ylpyrrolidin-3-yl)thiourea. The following compounds of the general formula (I) are particularly preferred: N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorophenyl)acetamide, 2-(2,5 -Dichlorophenyl)-N-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamide, N-(1-Cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorophenyl) acetamide, 2-(2,5-dichlorophenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)acetamide, 2-(2,5-dimethylphenyl)-N-(1-isopropyl-5-oxopyrrolidin- 3-yl)acetamide, N-(1-Isopropyl-5-oxopyrrolidin-3-yl)-2-(2-methylphenyl)acetamide, 2-(2-Chlorophenyl)-N-(1-cyclobutyl-5-oxopyrrolidin- 3-yl)acetamide, 1-(5-chloro-2-methylphenyl)-3-[1-(4-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl) -3-[1-(3-chlorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(6-chloropyridin-3-yl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3 -yl]urea, 1-(5-Chloro-2-methylphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(4-chlorophenyl)-3-(4 -methyl-5-oxo-1-phenylpyrrolidin-3-yl)urea, 1-(5-chloro-2-methylphenyl)-3-(5-oxo-1 -phenylpyrrolidin-3-yl)urea, 1-(5-chloro-2-methylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-chlorophenyl)- 3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]urea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)urea, 1-(5-Chloro-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidine-3- yl]urea, 1-(2-chlorophenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(2-fluorophenyl)-3-(4-methyl-5- oxo-1-phenylpyrrolidin-3-yl)urea, 1-(2-chlorophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)urea, 1-(5-chloro-2-methylphenyl)-3 -[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]urea, 1-(5-chloro-2-methylphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3-yl)urea, 1 -(2,5-Dichlorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]- 3-(2,5-dichlorophenyl)thiourea, 1-(2-chlorophenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]thiourea. In addition, some other of the aforementioned substituted pyrrolidinones of the general formula (I) are not yet known in the prior art. Thus, as a further part of the invention, substituted N-pyrrolidinones of the general formula (I) or their salts apply,
Figure imgf000066_0001
wherein R1 for (3-methylphenyl)methyl, (4-methylphenyl)methyl, (2-methylphenyl)methyl, (3-trifluoromethylphenyl)methyl, (4-trifluoroethylphenyl)methyl, (2-trifluoromethylphenyl)methyl, (3-chlorophenyl)methyl, (4-chlorophenyl)methyl, (3-fluorophenyl)methyl, (4-fluorophenyl)methyl, (2-fluorophenyl)methyl, (3,4-difluorophenyl)methyl, (3,4-dichlorophenyl)methyl, (3-fluoro -4-chlorophenyl)methyl, (3-chloro-4-fluorophenyl)methyl, (3,4-dimethylphenyl)methyl, (3,5-difluorophenyl)methyl, (3,5-dichlorophenyl)methyl, (3-fluoro- 5-chlorophenyl)methyl, (3-chloro-5-fluorophenyl)methyl, (3,5-dimethylphenyl)methyl, (3,5-ditrifluoromethylphenyl)methyl, (3-fluoro-5-trifluoromethylphenyl)methyl, (3-trifluoromethyl -5-fluorophenyl)methyl, (3-chloro-5-trifluoromethylphenyl)methyl, (3-trifluoromethyl-5-chlorophenyl)methyl, R2 stands for one of the following groups G-1 to G-2, where an arrow stands for a bond to the pyrrolidinone ring in the general formula (I).
Figure imgf000066_0002
R7 R represents hydrogen3, R4 independently for hydrogen, (C1-C8th)-alkyl, (C1-C10)-haloalkyl, (C3-C10)-cycloalkyl, aryl-(C1-C8th)-alkyl, aryl, R5, R6 independently for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C1-C10)-haloalkyl, (C3-C10)-cycloalkyl, aryl-(C1-C8th)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, heterocyclyl, heterocyclyl-(C1-C8th)-alkyl, R32O-(C1-C8th)-alkyl, R30R31N-(C1-C8th)-alkyl, NO30R31, OR32, (C3-C10)-cycloalkyl-(C1-C8th)-alkyl, R13, R14 independently for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, (C1-C10)-haloalkyl, (C3-C10)-cycloalkyl, aryl-(C1-C8th)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, heterocyclyl, heterocyclyl-(C1-C8th)-alkyl, R32O-(C1-C8th)-alkyl, R30R31N-(C1-C8th)-alkyl, (C3-C10)-cycloalkyl-(C1-C8th)-alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C8th)-alkyl, R30R31N(O)C-(C1-C8th)-alkyl, OR32 stand, r15 for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, aryl-(C1-C8th)-alkyl, heteroaryl-(C1-C8th)-alkyl, heterocyclyl-(C1-C8th)-alkyl, R32O-(C1-C8th)-alkyl, (C3-C10)-cycloalkyl-(C1-C8th)-alkyl, S(O)mR33, R32(O=)C-(C1-C8th)-alkyl, C(O=)R32, R32O(O)C-(C1-C8th)-alkyl, R30R31N(O)C-(C1-C8th)-alkyl, R30 and R31 independently for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, (C1-C8th)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C8th)-haloalkenyl, (C3-C8th)-haloalkynyl, (C3-C10)-cycloalkyl, (C3-C10)-halocycloalkyl, (C4-C10)-cycloalkenyl, (C4-C10)-halocycloalkenyl, (C1-C8th)-alkoxy-(C1-C8th)-alkyl, (C1-C8th)-haloalkoxy-(C1-C8th)-alkyl, (C1-C8th)-alkylthio-(C1-C8th)-alkyl, (C1-C8th)-haloalkylthio-(C1-C8th)-alkyl, (C1-C8th)-alkoxy-(C1-C8th)-haloalkyl, aryl, aryl-(C1-C8th)-alkyl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, (C3-C8th)-cycloalkyl-(C1-C8th)-alkyl, (C4-C10)-cycloalkenyl-(C1-C8th)-alkyl, COR32, SO2R33, heterocyclyl, (C1-C8th)-alkoxycarbonyl, bis[(C1- C8th)-alkyl]aminocarbonyl-(C1-C8th)-alkyl, (C1-C8th)-alkyl-aminocarbonyl-(C1-C8th)-alkyl, aryl-(C1- C8th)-alkyl-aminocarbonyl-(C1-C8th)-alkyl, aryl-(C1-C8th)-alkoxycarbonyl, heteroaryl-(C1-C8th)-alkoxycarbonyl, (C2-C8th)-alkenyloxycarbonyl, (C2-C8th)-alkynyloxycarbonyl, (C1-C8th)- alkoxycarbonyl-(C1-C8th)-alkyl, (C2-C8th)-alkenyloxycarbonyl-(C1-C8th)-alkyl, (C2-C8th)- alkynyloxycarbonyl-(C1-C8th)-alkyl, aryl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl, heteroaryl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl, heterocyclyl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl, heterocyclyl-(C1-C8th)-alkyl, or R30 and R31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R32 for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, (C1-C8th)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C8th)-haloalkenyl, (C3-C8th)-haloalkynyl, (C3-C10)-cycloalkyl, (C3-C10)-halocycloalkyl, (C4-C10)-cycloalkenyl, (C4-C10)-halocycloalkenyl, (C1-C8th)-alkoxy-(C1-C8th)-alkyl, (C1-C8th)-haloalkoxy-(C1-C8th)-alkyl, (C1-C8th)-alkoxy-(C1-C8th)-haloalkyl, (C1-C8th)-alkoxy- (C1-C8th)-alkoxy-(C1-C8th)-alkyl, (C1-C8th)-alkoxy-(C1-C8th)-alkoxy-(C1-C8th)-alkoxy-(C1-C8th)-alkyl, (C1-C8th)-alkoxy-(C1-C8th)-alkoxy-(C1-C8th)-alkoxy-(C1-C8th)-alkoxy-(C1-C8th)-alkyl, aryl, aryl-(C1-C8th)-alkyl, aryl-(C1-C8th)-alkoxy-(C1-C8th)-alkyl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, (C3-C8th)-cycloalkyl-(C1-C8th)-alkyl, (C4-C10)-cycloalkenyl-(C1-C8th)-alkyl, bis-[(C1-C8th)-alkyl]aminocarbonyl-(C1-C8th)-alkyl, (C1-C8th)-alkyl-aminocarbonyl-(C1-C8th)-alkyl, aryl-(C1-C8th)-alkylaminocarbonyl-(C1-C8th)-alkyl, bis-[(C1-C8th)-alkyl]amino-(C2-C6)-alkyl, (C1-C8th)-alkylamino-(C2-C6)-alkyl, aryl-(C1-C8th)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C8th)-alkyl, hydroxycarbonyl-(C1-C8th)-alkyl, heterocyclyl, heterocyclyl-(C1-C8th)-alkyl, tris-[(C1-C8th)-alkyl]silyl-(C1-C8th)-alkyl, bis-[(C1-C8th)-alkyl](aryl)silyl(C1-C8th)-alkyl, [(C1-C8th)-alkyl]-bis-(aryl)silyl-(C1-C8th)-alkyl, (C1-C8th)-alkylcarbonyloxy-(C1-C8th)-alkyl, (C3-C8th)-cycloalkylcarbonyloxy-(C1-C8th)-alkyl, arylcarbonyloxy-(C1-C8th)-alkyl, heteroarylcarbonyloxy-(C1-C8th)-alkyl, heterocyclylcarbonyloxy-(C1-C8th)-alkyl, aryloxy-(C1-C8th)-alkyl, heteroaryloxy- (C1-C8th)-alkyl, heterocyclyloxy-(C1-C8th)-alkyl, (C1-C8th)-alkoxycarbonyl, (C1-C8th)- alkoxycarbonyl-(C1-C8th)-alkyl, (C2-C8th)-alkenyloxycarbonyl-(C1-C8th)-alkyl, (C2-C8th)- alkynyloxycarbonyl-(C1-C8th)-alkyl, aryl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl, heteroaryl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl, heterocyclyl-(C1-C8th)-alkoxycarbonyl-(C1-C8th)-alkyl and R33 for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, (C1-C8th)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C8th)-haloalkenyl, (C3-C8th)-haloalkynyl, (C3-C10)-cycloalkyl, (C3-C10)-halocycloalkyl, (C4-C10)-cycloalkenyl, (C4-C10)-halocycloalkenyl, (C1-C8th)-alkoxy-(C1-C8th)-alkyl, (C1-C8th)-alkoxy-(C1-C8th)-haloalkyl, aryl, aryl-(C1-C8th)-alkyl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, heterocyclyl-(C1-C8th)-alkyl, (C3-C8th)-cycloalkyl-(C1-C8th)-alkyl, (C4-C10)-cycloalkenyl-(C1-C8th)-alkyl, bis-[(C1-C8th)-alkyl]amino, (C1-C8th)-alkyl-amino, aryl-(C1-C8th)-amino, aryl-(C1-C6)-alkyl-amino, aryl-[(C1-C8th)-alkyl]amino; heteroaryl-(C1-C8th)-amino, heteroaryl-(C1-C6)-alkyl-amino, heteroaryl-[(C1-C8th)-alkyl]amino; heterocyclyl-(C1-C8th)-amino, heterocyclyl-(C1-C6)-alkyl-amino, heterocyclyl-[(C1-C8th)-alkyl]amino; (C3-C8th)-cycloalkyl amino, (C3-C8th)-cycloalkyl-[(C1-C8th)-alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl. R35 for hydrogen, NO30R31, OR32, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, aryl, aryl-(C1-C8th)-alkyl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, heterocyclyl, heterocyclyl-(C1-C8th)-alkyl, R32O-(C1-C8th)-alkyl, (C3-C10)-cycloalkyl, (C3-C10)-cycloalkyl-(C1-C8th)-alkyl, S(O)mR33, R32(O=)C-(C1-C8th)-alkyl, R32O(O)C-(C1-C8th)-alkyl, R30R31N(O)C-(C1-C8th)-alkyl, R33SO)m- (C1-C8th)-alkyl, R32O-(C1-C8th)-alkyl, R30R31N-(C1-C8th)-alkyl, R36 for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, aryl, aryl-(C1-C8th)-alkyl, heteroaryl, heteroaryl-(C1-C8th)-alkyl, heterocyclyl, heterocyclyl-(C1-C8th)-alkyl, (C3-C10)-cycloalkyl, (C3-C10)-cycloalkyl-(C1-C8th)-alkyl, R32(O=)C-(C1-C8th)-alkyl, R32O(O)C-(C1-C8th)-alkyl, R30R31N(O)C-(C1-C8th)-alkyl, R33S(O)m-(C1-C8th)-alkyl, R32O-(C1-C8th)-alkyl, R30R31N-(C1-C8th)-alkyl and m is 0,1,2. Preference is given to compounds of the general formula (I) in which R1 for (3-methylphenyl)methyl, (4-methylphenyl)methyl, (2-methylphenyl)methyl, (3-trifluoromethylphenyl)methyl, (4-trifluoroethylphenyl)methyl, (2-trifluoromethylphenyl)methyl, (3-chlorophenyl)methyl, (4-chlorophenyl)methyl, (3-fluorophenyl)methyl, (4-fluorophenyl)methyl, (2-fluorophenyl)methyl, (3,4-difluorophenyl)methyl, (3,4-dichlorophenyl)methyl, (3-fluoro -4-chlorophenyl)methyl, (3-chloro-4-fluorophenyl)methyl, (3,4-dimethylphenyl)methyl, (3,5-difluorophenyl)methyl, (3,5-dichlorophenyl)methyl, (3-fluoro- 5-chlorophenyl)methyl, (3-chloro-5-fluorophenyl)methyl, (3,5-dimethylphenyl)methyl, (3,5-ditrifluoromethylphenyl)methyl, (3-fluoro-5-trifluoromethylphenyl)methyl, (3-trifluoromethyl -5-fluorophenyl)methyl, (3-chloro-5-trifluoromethylphenyl)methyl, (3-trifluoromethyl-5-chlorophenyl)methyl, R2 stands for one of the following groups G-1 to G-2, where an arrow stands for a bond to the pyrrolidinone ring in the general formula (I). G-1 G-2 R7 R represents hydrogen3, R4 independently for hydrogen, (C1-C7)-alkyl, (C1-C7)-haloalkyl, (C3-C7)-cycloalkyl, aryl-(C1-C7)-alkyl, aryl, R5, R6 independently for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C1-C7)-haloalkyl, (C3-C7)-cycloalkyl, aryl-(C1-C7)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, R32O-(C1-C7)-alkyl, R30R31N-(C1-C7)-alkyl, NO30R31, OR32, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, R13, R14 independently for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, (C1-C7)-haloalkyl, (C3-C7)-cycloalkyl, aryl-(C1-C7)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, R32O-(C1-C7)-alkyl, R30R31N-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C7)-alkyl, R30R31N(O)C-(C1-C7)-alkyl, OR32 stand, r15 for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, aryl-(C1-C7)-alkyl, heteroaryl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkyl, R32O-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, S(O)mR33, R32(O=)C-(C1-C7)-alkyl, C(O=)R32, R32O(O)C-(C1-C7)-alkyl, R30R31N(O)C-(C1-C7)-alkyl, R30 and R31 independently for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C1-C7)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C7)-haloalkenyl, (C3-C7)-haloalkynyl, (C3-C7)-cycloalkyl, (C3-C7)-halocycloalkyl, (C4-C7)-cycloalkenyl, (C4-C10)-halocycloalkenyl, (C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-haloalkoxy-(C1-C7)-alkyl, (C1-C7)-alkylthio-(C1-C7)-alkyl, (C1-C7)-haloalkylthio-(C1-C7)-alkyl, (C1-C7)-alkoxy-(C1-C7)-haloalkyl, aryl, aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, (C4-C7)-cycloalkenyl-(C1-C7)-alkyl, COR32, SO2R33, heterocyclyl, (C1-C7)-alkoxycarbonyl, bis[(C1- C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, aryl-(C1- C7)-alkylaminocarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxycarbonyl, heteroaryl-(C1-C7)-alkoxycarbonyl, (C2-C7)-alkenyloxycarbonyl, (C2-C7)-alkynyloxycarbonyl, (C1-C7)- alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)- alkynyloxycarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, heteroaryl- (C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkyl, or R30 and R31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R32 for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C1-C7)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C7)-haloalkenyl, (C3-C7)-haloalkynyl, (C3-C7)-cycloalkyl, (C3-C7)-halocycloalkyl, (C4-C7)-cycloalkenyl, (C4-C10)-halocycloalkenyl, (C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-haloalkoxy-(C1-C7)-alkyl, (C1-C7)-alkoxy-(C1-C7)-haloalkyl, (C1-C7)-alkoxy- (C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, aryl, aryl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxy-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, (C4-C10)-cycloalkenyl-(C1-C7)-alkyl, bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkylaminocarbonyl-(C1-C7)-alkyl, bis-[(C1-C7)-alkyl]amino-(C2-C6)-alkyl, (C1-C7)-alkylamino-(C2-C6)-alkyl, aryl-(C1-C7)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C7)-alkyl, hydroxycarbonyl-(C1-C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, tris-[(C1-C7)-alkyl]silyl-(C1-C7)-alkyl, bis-[(C1-C7)-alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, (C1-C7)-alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-cycloalkylcarbonyloxy-(C1-C7)-alkyl, arylcarbonyloxy-(C1-C7)-alkyl, heteroarylcarbonyloxy-(C1-C7)-alkyl, heterocyclylcarbonyloxy-(C1-C7)-alkyl, aryloxy-(C1-C7)-alkyl, heteroaryloxy- (C1-C7)-alkyl, heterocyclyloxy-(C1-C7)-alkyl, (C1-C7)-alkoxycarbonyl,(C1-C7)- alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)- alkynyloxycarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, heteroaryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl and R33 for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C1-C7)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C7)-haloalkenyl, (C3-C7)-haloalkynyl, (C3-C7)-cycloalkyl, (C3-C7)-halocycloalkyl, (C4-C7)-cycloalkenyl, (C4-C7)-halocycloalkenyl, (C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-alkoxy-(C1-C7)-haloalkyl, aryl, aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, (C4-C10)-cycloalkenyl-(C1-C7)-alkyl, bis-[(C1-C7)-alkyl]amino, (C1-C7)-alkyl-amino, aryl-(C1-C7)-amino, aryl-(C1- C6)-alkyl-amino, aryl-[(C1-C7)-alkyl]amino; heteroaryl-(C1-C7)-amino, heteroaryl-(C1-C6)-alkyl-amino, heteroaryl-[(C1-C7)-alkyl]amino; heterocyclyl-(C1-C7)-amino, heterocyclyl-(C1- C6)-alkyl-amino, heterocyclyl-[(C1-C7)-alkyl]amino; (C3-C7)-cycloalkyl-amino, (C3-C7)-cycloalkyl-[(C1-C7)-alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl. R35 for hydrogen, NO30R31, OR32, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, aryl, aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, R32O-(C1-C7)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, S(O)mR33, R32(O=)C-(C1-C7)-alkyl, R32O(O)C-(C1-C7)-alkyl, R30R31N(O)C-(C1-C7)-alkyl, R33S(O)m-(C1-C7)-alkyl, R32O-(C1-C7)-alkyl, R30R31N-(C1-C7)-alkyl, R36 for hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, aryl, aryl-(C1-C7)-alkyl, heteroaryl, heteroaryl-(C1-C7)-alkyl, heterocyclyl, heterocyclyl-(C1-C7)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, R32(O=)C-(C1-C7)-alkyl, R32O(O)C-(C1-C7)-alkyl, R30R31N(O)C-(C1-C7)-alkyl, R33S(O)m-(C1-C7)-alkyl, R32O-(C1-C7)-alkyl, R30R31N-(C1-C7)-alkyl and m is 0,1,2. Particularly preferred are compounds of the general formula (I) in which R1 for (3-methylphenyl)methyl, (4-methylphenyl)methyl, (2-methylphenyl)methyl, (3-trifluoromethylphenyl)methyl, (4-trifluoroethylphenyl)methyl, (2-trifluoromethylphenyl)methyl, (3-chlorophenyl)methyl, (4-chlorophenyl)methyl, (3-fluorophenyl)methyl, (4-fluorophenyl)methyl, (2-fluorophenyl)methyl, (3,4-difluorophenyl)methyl, (3,4-dichlorophenyl)methyl, (3-fluoro -4-chlorophenyl)methyl, (3-chloro-4-fluorophenyl)methyl, (3,4-dimethylphenyl)methyl, (3,5-difluorophenyl)methyl, (3,5-dichlorophenyl)methyl, (3-fluoro- 5-chlorophenyl)methyl, (3-chloro-5-fluorophenyl)methyl, (3,5-dimethylphenyl)methyl, (3,5-ditrifluoromethylphenyl)methyl, (3-fluoro-5-trifluoromethylphenyl)methyl, (3-trifluoromethyl -5-fluorophenyl)methyl, (3-chloro-5-trifluoromethylphenyl)methyl, (3-trifluoromethyl-5-chlorophenyl)methyl, R2 stands for one of the following groups G-1 to G-2, where an arrow stands for a bond to the pyrrolidinone ring in the general formula (I),
Figure imgf000073_0001
R7 is hydrogen, R3, R4 independently for hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, aryl-(C1-C6)-alkyl,, aryl, R5, R6 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, NO30R31, OR32, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, R13, R14 independently for hydrogen, (C1-C8th)-alkyl, (C2-C8th)-alkenyl, (C2-C8th)-alkynyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, aryl-(C1-C6)-alkyl, aryl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, OR32 stand, r15 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, S(O)mR33, R32(O=)C-(C1-C6)-alkyl, C(O=)R32, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, R30 and R31 independently for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C10)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-haloalkoxy-(C1-C6)-alkyl, (C1-C6)-alkylthio-(C1-C6)-alkyl, (C1-C6)-haloalkylthio-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C6)-cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, heterocyclyl, (C1-C6)-alkoxycarbonyl, bis[(C1- C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1- C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-alkenyloxycarbonyl, (C2-C6)-alkynyloxycarbonyl, (C1-C6)- alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)- alkynyloxycarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, or R30 and R31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R32 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C10)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-haloalkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, (C1-C6)-alkoxy- (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, aryl, aryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C6)-cycloalkenyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkylaminocarbonyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-alkylamino-(C2-C6)-alkyl, aryl-(C1-C6)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, hydroxycarbonyl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, tris-[(C1-C6)-alkyl]silyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1-C6)-alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-cycloalkylcarbonyloxy-(C1-C6)-alkyl, arylcarbonyloxy-(C1-C6)-alkyl, heteroarylcarbonyloxy-(C1-C6)-alkyl, heterocyclylcarbonyloxy-(C1-C6)-alkyl, aryloxy-(C1-C6)-alkyl, heteroaryloxy- (C1-C6)-alkyl, heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-alkoxycarbonyl, (C1-C6)- alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)- alkynyloxycarbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, R33 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-cyanoalkyl, (C1-C10)-haloalkyl, (C2-C6)-haloalkenyl, (C3-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)- halocycloalkyl, (C4-C6)-cycloalkenyl, (C4-C6)-halocycloalkenyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C4-C6)-cycloalkenyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl]amino, (C1-C6)-alkyl-amino, aryl-(C1-C6)-amino, aryl-(C1- C6)-alkyl-amino, aryl-[(C1-C6)-alkyl]amino; heteroaryl-(C1-C6)-amino, heteroaryl-(C1-C6)-alkyl-amino, heteroaryl-[(C1-C6)-alkyl]amino; heterocyclyl-(C1-C6)-amino, heterocyclyl-(C1- C6)-alkyl-amino, heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-cycloalkyl-amino, (C3-C6)-cycloalkyl-[(C1-C6)-alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R35 for hydrogen, NO30R31, OR32, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, S(O)mR33, R32(O=)C-(C1-C6)-alkyl, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, R33S(O)m-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl, R36 for hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, heteroaryl-(C1-C6)-alkyl, heterocyclyl, heterocyclyl-(C1-C6)-alkyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-alkyl, R32O(O)C-(C1-C6)-alkyl, R30R31N(O)C-(C1-C6)-alkyl, R33S(O)m-(C1-C6)-alkyl, R32O-(C1-C6)-alkyl, R30R31N-(C1-C6)-alkyl and represents 0,1,2. Very particular preference is given to compounds of the general formula (I) in which R1 for (3-methylphenyl)methyl, (4-methylphenyl)methyl, (2-methylphenyl)methyl, (3-trifluoromethylphenyl)methyl, (4-trifluoroethylphenyl)methyl, (2-trifluoromethylphenyl)methyl, (3-chlorophenyl)methyl, (4-chlorophenyl)methyl, (3-fluorophenyl)methyl, (4-fluorophenyl)methyl, (2-fluorophenyl)methyl, (3,4-difluorophenyl)methyl, (3,4-dichlorophenyl)methyl, (3-fluoro -4-chlorophenyl)methyl, (3-chloro-4-fluorophenyl)methyl, (3,4-dimethylphenyl)methyl, (3,5-difluorophenyl)methyl, (3,5-dichlorophenyl)methyl, (3-fluoro- 5-chlorophenyl)methyl, (3-chloro-5-fluorophenyl)methyl, (3,5-dimethylphenyl)methyl, (3,5-ditrifluoromethylphenyl)methyl, (3- fluoro-5-trifluoromethylphenyl)methyl, (3-trifluoromethyl-5-fluorophenyl)methyl, (3-chloro-5-trifluoromethylphenyl)methyl, (3-trifluoromethyl-5-chlorophenyl)methyl, R2 stands for one of the above groups G-1 and G-2, where X stands for the group O-R36 and N(R15)r35 stands in the groups G-1 and G-2 and has the meaning described below and wherein an arrow stands for a bond to the pyrrolidinone ring in the general formula (I),
Figure imgf000076_0001
from G-1 R7 is hydrogen, R3, R4 independently represent hydrogen, methyl, ethyl, 1-methylethy-1-yl, difluoromethyl, R5, R6 independently represent hydrogen, methyl, ethyl, 1-methyleth-1-yl, 1,1-dimethyleth-1-yl, phenyl, 4-fluorophenyl, 4-chlorophenyl, hydroxy, methoxy, trifluoromethyloxy, R13, R14 are independently hydrogen, methyl, ethyl, 1-methyleth-1-yl, 1,1-dimethyleth-1-yl and, X is OH, (1-methyl-1H-1,2,4-triazol-5- yl)amino, (1-ethyl-1H-1,2,4-triazol-5-yl)amino, (1-methyl-1H-tetrazol-5-yl)amino, (1-ethyl-1H-tetrazole-5 -yl)amino, [1-carboxy-2-methylbutyl]amino, [(1S,2S)-1-carboxy-2-methylbutyl]amino, [(1R,2S)-1-carboxy-2-methylbutyl]amino, [(1R,2R)-1-carboxy-2-methylbutyl]amino, [(1S,2R)-1-carboxy-2-methylbutyl]amino, (5-methoxy-2,5-dioxopentyl)amino, 2-( 4-fluorophenoxy)ethoxy; methoxy; 2-methylsulfonylethoxy; 2-methylsulfanylethoxy; methanesulfonamido; 2-carboxypyrrolidin-1-yl, 2-methoxyethoxy, cyclopentyloxy, 2,2-dimethylpropoxy, ethoxy, cyclopropylmethoxy, prop-2-en-1-yloxy, 2-phenylsulfanylethoxy, prop-2-yn-1-yloxy, cyclobutyloxy, isopropyloxy, but-3-enoxy, 2-phenoxyethoxy, pentan-2-yloxy, 2-(4-chlorophenyl)sulfinylethoxy, butan-2-yloxy, 2-(4-methoxyphenoxy)ethoxy, 2-(benzenesulfonyl)ethoxy, 2 -(4-chlorophenoxy)ethoxy, 2-(4-methylphenoxy)ethoxy, 3-methylbutan-2-yloxy, [3-(1H-imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl] amino, [(2R)-3-(1H-imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl]amino, [(2S)-3-(1H-imidazol-4-yl)- 1-methoxy-1-oxopropan-2-yl]amino, 2-[(4-chlorophenyl)thio]ethoxy, [1-carboxy-2-phenylethyl]amino, [(1R)-1-carboxy-2-phenylethyl] amino, [(1S)-1-carboxy-2- phenylethyl]amino, [1-carboxy-2-(4-hydroxyphenyl)ethyl]amino, [(1R)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino, [(1S)-1-carboxy-2 -(4-hydroxyphenyl)ethyl]amino, [1-carboxy-2-(4-methoxyphenyl)ethyl]amino, [(1R)-1-carboxy-2-(4-methoxyphenyl)ethyl]amino, [(1S) -1-carboxy-2-(4-methoxyphenyl)ethyl]amino, 2-[(4-methoxyphenyl)thio]ethoxy, 2-[(4-methylphenyl)thio]ethoxy, [1-carboxy-3-methylbutyl]amino , [(1R)-1-carboxy-3-methylbutyl]amino, [(1S)-1-carboxy-3-methylbutyl]amino, (4-methyl-1,2,5-oxadiazol-3-yl)amino, 2-(4-methylphenyl)sulfinylethoxy, [1-(methoxycarbonyl)cyclopropyl]amino, 2-hydroxyethylamino, [3-(1H-imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl]amino, [(2S)-3-(1H-imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl]amino, [(2R)-3-(1H-imidazol-4-yl)-1- methoxy-1-oxopropan-2-yl]amino, [1-carboxy-2-methoxyethyl]amino, [(1R)-1-carboxy-2-methoxyethyl]amino, [(1S)-1-carboxy-2-methoxyethyl ]amino, [1-carboxy-2-methylthioethyl]amino, [(1R)-1-carboxy-2-methylthioethyl]amino, [(1S)-1-carboxy-2-methyl thioethyl]amino, [1-carboxyethyl]amino, [(1R)-1-carboxyethyl]amino, [(1S)-1-carboxyethyl]amino, [1-carboxy-2-methylpropyl]amino, [(1R)-1 -carboxy-2-methylpropyl]amino, [(1S)-1-carboxy-2-methylpropyl]amino, trifluoromethylsulfonylamino, (2-methoxy-2-oxoethyl)methylamino, 2-(4-methoxyphenyl)sulfonylethoxy, benzylamino, 2 - methylpropylamino, amino, 2,2-dimethylhydrazino, hydrazino, prop-2-en-1-ylamino, 2-(4-methoxyphenyl)sulfinylethoxy, 2-phenylethylamino, (6-chloropyridin-3-yl)methylmethylamino, ( 4-methoxy-4-oxobutan-2-yl)amino, [(2S)-4-methoxy-4-oxobutan-2-yl)]amino, [(2R)-4-methoxy-4-oxobutan-2-yl )]amino, [2-isopropyl-5-methylcyclohexyl]oxy, [(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl]oxy, [(1S,2R,5R)-2-isopropyl-5-methylcyclohexyl ]oxy, [(1R,2R,5S)-2-isopropyl-5-methylcyclohexyl]oxy, [(1R,2R,5R)-2-isopropyl-5-methylcyclohexyl]oxy, [(1S,2S,5S)- 2-isopropyl-5-methylcyclohexyl]oxy, [(1S,2S,5R)-2-isopropyl-5-methylcyclohexyl]oxy, [(1R,2S,5S)-2-isopropyl-5-methylcyclohexyl]oxy, [( 1R,2S ,5R)-2-isopropyl-5-methylcyclohexyl]oxy, 1,2,3,4-tetrahydronaphthalene-1-ylamino, [1-carboxy-2-(1H-indol-3-yl)ethyl]amino, [( 1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino, [(1R)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino, pyrrolidine-1- yl, ethylsulfonylamino, diethylamino, difluoromethylsulfonylamino, isopropylsulfonylamino, pyridin-2-ylmethylamino, quinolin-5-ylmethylamino, 2-(methoxycarbonyl)anilino, 2-(3,4-dichlorophenyl)ethylamino, 2,2,2, trifluoroethylsulfonylamino, dimethylsulfamoylamino, (3-methoxy-3-oxopropyl)amino, (1-ethyl-1H-pyrazol-3-yl)methylamino, cyclopropylsulfonylamino, tert-butoxy, 2,2,2-trifluoroethylamino, 2-methoxyethylamino, ethoxyethylamino, prop-2- yn-1-ylamino, (2-ethylphenyl)methylamino, (1-ethyl-3-methyl-1H-pyrazol-4-yl)methylamino, 3-methylbutylamino, 2-(2-bromophenyl)ethylamino, ethylamino, 2-( 3,5-dimethoxyphenyl)ethylamino, N-methylanilino, methylsulfonylazanidyl, (6-chloropyridin-3-yl)methylamino, 2-(2,4-difluorophenyl)ethylamino, methylamino, [2,6-dimethylindan-1-yl ]amino, [(1R,2S)-2,6-dimethylindan-1-yl]amino, [(1R,2R)-2,6-dimethylindan-1-yl]amino, [(1S,2S)-2, 6-dimethylindan-1-yl]amino, [(1S,2R)-2,6- dimethylindan-1-yl]amino, 2-(1,3-benzodioxol-5-yl)ethylamino, butan-2-ylamino, 2-(1H-indol-3-yl)ethylamino, propylamino, 2-(2,6 -difluorophenyl)ethylamino, 2-(3-methylphenyl)ethylamino, 2-[3-(trifluoromethoxy)phenyl]ethylamino, indan-1-ylamino, quinolin-6-ylmethylamino, [1-tert-butoxy-3-(4- hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2S)-1-tert-butoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2R)-1-tert -butoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, [1-methoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2S)-1 - methoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2R)-1-methoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, [1 -tert-butoxy-3-phenyl-1-oxopropan-2-yl]amino, [(2S)-1-tert-butoxy-3-phenyl-1-oxopropan-2-yl]amino, [(2R)-1 - tert -butoxy-3-phenyl-1-oxopropan-2-yl]amino, [1-methoxy-3-phenyl-1-oxopropan-2-yl]amino, [(2S)-1-methoxy-3-phenyl -1-oxopropan-2-yl]amino, [(2R)-1-methoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, 2-(4-tert-butylphenyl)ethylamino, cyclopropylamino , is opropylamino, 2-(ethoxycarbonyl)piperidin-1-yl, (1-n-propyl-1H-1,2,4-triazol-5-yl)amino, 2-(2-fluorophenyl)ethylamino, (2-methoxy- 2-oxoethyl)methylamino, 2-(ethoxycarbonyl)piperidin-1-yl, benzhydrylamino, dimethylsulfamoylamino, N -propylanilino, cyclobutylamino, cyclohexylmethylamino, N -ethylanilino, (2-methoxy-2-oxoethyl)methylamino, 2-(ethoxycarbonyl )piperidin-1-yl, 3-(diethylamino)propylamino, (2,4-difluorophenyl)methylamino, 2-(5-hydroxy-1H-indol-3-yl)ethylamino, anilino, cyclopentylamino, cyclohexylamino, 2-[3 - (trifluoromethyl)phenyl]ethylamino, 2-(diethylamino)ethylamino, isoquinolin-5-ylmethylamino, carboxymethyl(methyl)amino, 2-(4-fluorophenyl)ethylamino, 2-(5-methoxy-1H-indol-3-yl). )ethylamino, carboxymethyl(ethyl)amino, 2-[4-(trifluoromethoxy)phenyl]ethylamino, 2-(3-bromophenyl)ethylamino, 2-(2,5-dichlorophenyl)ethylamino, 2-thiophen-2-ylethylamino, 2 -(2-methoxyphenyl)ethylamino, 2-(3,4-dimethoxyphenyl)ethylamino, (4-methoxy-4-oxobutyl)amino, 2-(4-chlorophenyl)ethylamino, 2- pyridin-3-ylethylamino, 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethylamino, cyclopentylsulfonylamino, 2-(4-methoxyphenyl)ethylamino, 2-(3-methoxyphenyl)ethylamino, 2-(2 ,3-dichlorophenyl)ethylamino, 2-[3,5-bis(trifluoromethyl)phenyl]ethylamino, 2-(4-methylphenyl)ethylamino, 2-(3-chlorophenyl)ethylamino, 2-(2-chlorophenyl)ethylamino, 2 -pyridin-2-ylethylamino, 2-(2,4-dichlorophenyl)ethylamino, 2-(3-fluorophenyl)ethylamino, 2,2-difluoroethylamino, 1,3-dimethoxy-1,3-dioxopropan-2-yl, 5 -hydroxy-1,3-dimethyl-1H-pyrazol-4-yl, 3,3-dimethyl-2,6-dioxocyclohexyl, 4,4-dimethyl-2,6-dioxocyclohexyl, 4-methyl-2,6-dioxocyclohexyl , 2,5-dioxocyclopentyl, dicyanomethyl, 2,4-dioxo-3-bicyclo[3.2.1]octanyl, 3,3,5,5-tetramethyl-2,4,6-trioxocyclohexyl, 2,6-dioxocyclohexyl, 2 ,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl, 5-hydroxy-1-methyl-1H-pyrazol-4-yl, 1-cyano-2-methoxy-2-oxoethyl, 1 -methoxy-1,3-dioxobutan-2-yl, 2,4-dioxo-3-bicyclo[3.2.1]oct-6-enyl, phenylsulfonyl, ethoxyethoxy, methoxyethoxyethoxy, hydroxyeth oxy, hydroxyethoxyethoxy, hydroxyethoxyethoxyethoxy, cyclopropylmethoxy, cyclobutylmethoxy, cyclopentylmethoxy, cyclohexylmethoxy, cyclopropylmethylamino, cyclobutylmethylamino, cyclopentylmethylamino, cyclohexylmethylamino, oxetan-3-yloxy, oxetan-3-ylamino, tetrahydrofuran-2-yloxy, tetrahydrofuran-3-yloxy, tetrahydrofuran-2-ylmethoxy, tetrahydrofuran-3-ylmethoxy, tetrahydrofuran-2-ylamino, tetrahydrofuran- 3-ylamino, tetrahydrofuran-2-ylmethylamino, tetrahydrofuran-3-ylmethylamino, benzyloxy, 4-fluorobenzyloxy, 4-chlorobenzyloxy, 3-fluorobenzyloxy, 3-chlorobenzyloxy, 2-fluorobenzyloxy, 2-chlorobenzyloxy, 4-fluorobenzylamino, 4-chlorobenzylamino, 3-fluorobenzylamino, 3-chlorobenzylamino, 2-fluorobenzylamino, 2-chlorobenzylamino, pyridin-3-ylmethylamino, pyridin-4-ylmethylamino, 4-chloro-pyridin-2-ylmethylamino, 4-chloro-pyridin-3-ylmethylamino, 4- trifluoromethyl-pyridin-3-ylmethylamino, pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, 4-chloro-pyridin-2-ylmethoxy, 4-chloro-pyridin-3-ylmethoxy, cyanomethylamino, cyanomethoxy, cyanoethoxy, hydroxycarbonylmethylamino, hydroxycarbonylmethoxy, hydroxycarbonylethoxy, hydroxycarbonylethylam ino, methoxycarbonylmethylamino, ethoxycarbonylmethylamino, azetidin-1-ylamino, pyrrolidin-1-ylamino, piperidin-1-ylamino, ethylthioethoxy, 1,2,4-thiadiazol-5-ylamino, 5-(difluoromethyl)-1,3 ,4-thiadiazol-2-ylamino, 5-tert-butyl-1,2-oxazol-3-ylamino, 4-(trifluoromethyl)pyridin-2-ylamino, 5-chloro-4-(trifluoromethyl)pyridin-2-ylamino , (pyridin-4-ylmethoxy)amino, hydroxyamino, methoxyamino, ethoxyamino, benzyloxyamino, methyl(methoxy)amino, methoxycarbonylmethoxyamino, ethoxycarbonylmethoxyamino, methoxycarbonylethoxyamino, ethoxycarbonylethoxyamino, hydroxycarbonylmethoxyamino, hydroxycarbonylethoxyamino, benzyloxycarbonylmethoxyamino, benzyloxycarbonylmethoxyamino, (1,1-dimethyleth-1-yl )oxycarbonylmethoxyamino, (1,1-dimethyleth-1-yl)oxycarbonylmethoxyamino. The following compounds of the general formula (I) are particularly preferred: 4-[2-[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]oxyethoxy]benzoic acid, 2-( 4-formylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, (2R)-2-[[2-[1-[(4-methylphenyl)methyl] -5-oxopyrrolidin-2-yl]acetyl]amino]-4-methylsulfanylbutyric acid, 2-(4-ethylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, 2-(4-methylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, N-Benzyl-2-[1-[(4-methylphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetamide, butan-2-yl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetate, (2S)-3-(1H-indole -3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionic acid, N-butan-2-yl-2-[1 -[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, (2R)-4-methyl-2-[[2-[(2R)-1-[(4-methylphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetyl]amino]pentanecarboxylic acid, (2S)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopy rrolidin-2-yl]acetyl]amino]-3-phenylpropionic acid, (2R)-1-[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]pyrrolidin-2- carboxylic acid, (2S)-2-[[2-[(2S)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidine-2- yl]acetyl]amino]-3-phenylpropionic acid, methyl 2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]benzoate, N-cyclopropyl-2- [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, N-(Isoquinolin-5-ylmethyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin- 2-yl]acetamide, N -[2-(2-bromophenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, (2R)-3-( 1H-indol-3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionic acid, N -[2-(1H-indole -3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin- 2-yl]-N-(quinolin-6-ylmethyl)acetamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl] -5-oxopyrrolidin-2-yl]acetamide, N-[(1-ethyl-1H-pyrazol-3-yl)methyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamide, N -[2-(Diethylamino)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide, (2S,3S)-3-methyl- 2 -[[2-[(2S)-1-[(3-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]pentanecarboxylic acid, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]propionic acid, methyl (2S)-3-(1H-imidazol-4- yl)-2-[[2-[(2R)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propionate, 2-[1-[(4-fluorophenyl) methyl]-5-oxo-3-phenylpyrrolidin-2-yl]acetic acid, 2-[1-[(3-Fluorophenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]acetic acid, methyl-2-[ 1-[(3,4-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]propionate, N -[2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl]-2-[ 1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamide. The definitions of radicals given above in general or in preferred ranges apply both to the end products of the formula (I) and correspondingly to the starting materials or intermediates required in each case for the preparation. These radical definitions can be combined with one another as desired, ie also between the specified preferred ranges. Mainly for reasons of increased stress tolerance and/or better manufacturability, compounds of the formula (I) according to the invention or their salts or their use according to the invention are of particular interest, in which individual radicals have one of the preferred meanings already mentioned or mentioned below, or in particular those in which one or more of the preferred meanings already mentioned or mentioned below occur in combination. With regard to the compounds according to the invention, the designations used above and below are explained. These are familiar to the person skilled in the art and have in particular the meanings explained below: Unless defined otherwise, it generally applies to the designation of chemical groups that the connection to the structure or the remainder of the molecule takes place via the last-mentioned structural element of the chemical group in question , i.e. for example in the case of (C2-C8th)-alkenyloxy via the oxygen atom, and in the case of heterocyclyl-(C1-C8th)-alkyl or R32O(O)C-(C1-C8th)-alkyl in each case via the carbon atom of the alkyl group. In a composite chemical group such as B. Heterocyclyl- (C1-C8th)-alkyl or R32O(O)C-(C1-C8th)-alkyl, the term “alkyl” therefore also stands for an alkylene group. For the functional groups C(=O)R32, C(=O)OR32, C(=O)NR30R31, NO30R31, OR32, S(O)mR33 the attachment to the framework or the rest of the molecule takes place via the first-mentioned structural element of the relevant chemical group. According to the invention, "alkylsulfonyl" - alone or as part of a chemical group - represents straight-chain or branched alkylsulfonyl, preferably having 1 to 8, or having 1 to 6 carbon atoms, e.g. (but not limited to) (C1-C6)-alkylsulfonyl such as methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methylpropylsulfonyl, 1,1-dimethylethylsulfonyl, pentylsulfonyl, 1-methylbutylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, 1,1-dimethylpropylsulfonyl, 1,2-dimethylpropylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylpropylsulfonyl, hexylsulfonyl, 1-methylpentylsulfonyl, 2-methylpentylsulfonyl, 3-methylpentylsulfonyl, 4-methylpentylsulfonyl, 1,1-dimethylbutylsulfonyl, 1,2-dimethylbutylsulfonyl, 1,3-dimethylbutylsulfonyl, 2,2-dimethylbutylsulfonyl, 2,3-dimethylbutylsulfonyl, 3,3-dimethylbutylsulfonyl, 1-ethylbutylsulfonyl, 2-ethylbutylsulfonyl, 1,1,2-trimethylpropylsulfonyl, 1, 2,2-trimethylpropylsulfonyl, 1-ethyl-1-methylpropylsulfonyl and 1-ethyl-2-methylpropylsulfonyl. According to the invention, "heteroarylsulfonyl" represents optionally substituted pyridylsulfonyl, pyrimidinylsulfonyl, pyrazinylsulfonyl or optionally substituted polycyclic heteroarylsulfonyl, here in particular optionally substituted quinolinylsulfonyl, for example substituted by fluorine, chlorine, bromine, iodine, cyano, nitro, alkyl, haloalkyl, haloalkoxy, amino -, alkylamino, alkylcarbonylamino, dialkylamino or alkoxy groups. According to the invention, “alkylthio”—on its own or as part of a chemical group—is straight-chain or branched S-alkyl, preferably having 1 to 8 or 1 to 6 carbon atoms, such as (C1-C10)-, (C1-C6)- or (C1-C4)-alkylthio, e.g. (but not limited to) (C1- C6)-alkylthio such as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio, 1,1-dimethylethylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 2,2-dimethylpropylthio, 1-ethylpropylthio, hexylthio, 1-methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1-dimethylbutylthio, 1,2-dimethylbutylthio, 1, 3-dimethylbutylthio, 2,2-dimethylbutylthio, 2,3-dimethylbutylthio, 3,3-dimethylbutylthio, 1-ethylbutylthio, 2-ethylbutylthio, 1,1,2-trimethylpropylthio, 1,2,2-trimethylpropylthio, 1-ethyl-1-methylpropylthio and 1-ethyl-2-methylpropylthio. According to the invention, “alkenylthio” means an alkenyl radical bonded via a sulfur atom, alkynylthio means an alkynyl radical bonded via a sulfur atom, cycloalkylthio means a cycloalkyl radical bonded via a sulfur atom, and cycloalkenylthio means a cycloalkenyl radical bonded via a sulfur atom. According to the invention, “alkylsulfinyl (alkyl-S(=O)-)”, unless otherwise defined elsewhere, represents alkyl radicals which are bonded to the skeleton via -S(=O)-, such as (C1-C10)-, (C1-C6)- or (C1-C4)-alkylsulphinyl, e.g. B. (but not limited to) (C1-C6)-alkylsulphinyl such as methylsulphinyl, ethylsulphinyl, propylsulphinyl, 1-methylethylsulphinyl, butylsulphinyl, 1-methylpropylsulphinyl, 2-methylpropylsulphinyl, 1,1-dimethylethylsulphinyl, pentylsulphinyl, 1-methylbutylsulphinyl, 2-methylbutylsulphinyl, 3-methylbutylsulphinyl, 1,1-dimethylpropylsulphinyl, 1,2-dimethylpropylsulphinyl, 2,2-dimethylpropylsulphinyl, 1-ethylpropylsulphinyl, hexylsulphinyl, 1-methylpentylsulphinyl, 2-methylpentylsulphinyl, 3-methylpentylsulphinyl, 4-methylpentylsulphinyl, 1,1-dimethylbutylsulphinyl, 1,2-dimethyl- butylsulphinyl, 1,3-dimethylbutylsulphinyl, 2,2-dimethylbutylsulphinyl, 2,3-dimethylbutylsulphinyl, 3,3-dimethylbutylsulphinyl, 1-ethylbutylsulphinyl, 2-ethylbutylsulphinyl, 1,1,2-trimethylpropylsulphinyl, 1,2,2-trimethylpropylsulphinyl, 1-ethyl-1-methylpropylsulphinyl and 1-ethyl-2-methylpropylsulphinyl. Analogous are “alkenylsulphinyl” and “alkynylsulphinyl”, defined according to the invention as alkenyl or alkynyl radicals which are bonded to the skeleton via -S(=O)-, such as (C2-C10)-, (C2-C6)- or (C2-C4)- alkenylsulphinyl or (C3-C10)-, (C3-C6)- or (C3-C4)-alkynylsulphinyl. Analogously, "alkenylsulfonyl" and "alkynylsulfonyl" are defined according to the invention as alkenyl or alkynyl radicals which are bonded to the skeleton via -S(=O)2-, such as (C2-C10)-, (C2-C6)- or (C2-C4)- alkenylsulfonyl or (C3-C10)-, (C3-C6)- or (C3-C4)-alkynylsulfonyl. "Alkoxy" means an alkyl radical bonded through an oxygen atom, e.g. B. (but not limited to) (C1-C6)-Alkoxy such as methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1-dimethylethoxy, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1, 3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl- 1-methyl-propoxy and 1-ethyl-2-methylpropoxy. Alkenyloxy means an alkenyl radical bonded via an oxygen atom, alkynyloxy means an alkynyl radical bonded via an oxygen atom such as (C2-C10)-, (C2-C6)- or (C2-C4)-alkenoxy or (C3-C10)-, (C3-C6)- or (C3-C4)-alkynoxy. "Cycloalkyloxy" means an oxygen-bonded cycloalkyl radical and cycloalkenyloxy means an oxygen-bonded cycloalkenyl radical. According to the invention, "alkylcarbonyl" (alkyl-C(=O)-), unless otherwise defined elsewhere, represents alkyl radicals which are bonded to the skeleton via -C(=O)-, such as (C1-C10)-, (C1-C6)- or (C1-C4)-alkylcarbonyl. The number of carbon atoms refers to the alkyl radical in the alkylcarbonyl group. According to the invention, “alkenylcarbonyl” and “alkynylcarbonyl”, unless otherwise defined elsewhere, stand for alkenyl or alkynyl radicals which are bonded to the skeleton via —C(═O)—, such as (C2-C10)-, (C2-C6)- or (C2-C4)-alkenylcarbonyl or (C2-C10)-, (C2-C6)- or (C2-C4)- alkynylcarbonyl. The number of carbon atoms refers to the alkenyl or alkynyl radical in the alkenyl or alkynylcarbonyl group. "Alkoxycarbonyl (alkyl-O-C(=O)-)", unless otherwise defined elsewhere: alkyl radicals which are bonded to the skeleton via -O-C(=O)-, such as (C1-C10)-, (C1-C6)- or (C1-C4)-alkoxycarbonyl. The number of carbon atoms refers to the alkyl radical in the alkoxycarbonyl group. According to the invention, “alkenyloxycarbonyl” and “alkynyloxycarbonyl”, unless otherwise defined elsewhere, stand for alkenyl or alkynyl radicals which are bonded to the skeleton via —O—C(=O)—, such as (C2-C10)-, (C2-C6)- or (C2-C4)-alkenyloxycarbonyl or (C3-C10)-, (C3-C6)- or (C3-C4)- alkynyloxycarbonyl. The number of carbon atoms refers to the alkenyl or alkynyl radical in the alkene or alkynyloxycarbonyl group. According to the invention, the term “alkylcarbonyloxy” (alkyl-C(=O)-O-), unless otherwise defined elsewhere, represents alkyl radicals attached to the oxygen via a carbonyloxy group (-C(=O)-O-). are bound to the skeleton, like (C1-C10)-, (C1-C6)- or (C1-C4)-alkylcarbonyloxy. The number of carbon atoms refers to the alkyl radical in the alkylcarbonyloxy group. Analogously, “alkenylcarbonyloxy” and “alkynylcarbonyloxy” are defined according to the invention as alkenyl or alkynyl radicals which are bonded to the skeleton with the oxygen via (-C(=O)-O-), such as (C2-C10)-, (C2-C6)- or (C2-C4)-alkenylcarbonyloxy or (C2-C10)-, (C2-C6)- or (C2-C4)-alkynylcarbonyloxy. The number of carbon atoms refers to the alkenyl or alkynyl radical in the alkenyl or alkynylcarbonyloxy group. In short forms such as C(O)R12, C(O)OR12, OC(O)NO10R11, or C(O)NO10R11 the abbreviation O given in brackets stands for an oxygen atom bonded to the adjacent carbon atom via a double bond. In short forms such as OC(S)OR12, OC(S)SR13, OC(S)NO10R11, the abbreviation S given in brackets stands for a sulfur atom bonded to the neighboring carbon atom via a double bond. The term “aryl” means an optionally substituted mono-, bi- or polycyclic aromatic system having preferably 6 to 14, in particular 6 to 10, ring carbon atoms, for example phenyl, naphthyl, anthryl, phenanthrenyl and the like, preferably phenyl. The term “optionally substituted aryl” also includes polycyclic systems such as tetrahydronaphthyl, indenyl, indanyl, fluorenyl and biphenylyl, the binding site being on the aromatic system. Systematically, “aryl” is generally also included in the term “optionally substituted phenyl”. Preferred aryl substituents here are, for example, hydrogen, halogen, alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, halocycloalkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkoxyalkyl, alkylthio, haloalkylthio, haloalkyl, alkoxy, Haloalkoxy, cycloalkoxy, cycloalkylalkoxy, aryloxy, heteroaryloxy, alkoxyalkoxy, alkynylalkoxy, alkenyloxy, bis-alkylaminoalkoxy, tris-[alkyl]silyl, bis-[alkyl]arylsilyl, bis-[alkyl]alkylsilyl, tris-[alkyl]silylalkynyl, arylalkynyl, heteroarylalkynyl, alkylalkynyl, cycloalkylalkynyl, haloalkylalkynyl, heterocyclyl-N-alkoxy, nitro, cyano, amino, alkylamino, bis-alkylamino, alkylcarbonylamino, cycloalkylcarbonylamino, arylcarbonylamino, alkoxycarbonylamino, alkoxycarbonylalkylamino, arylalkoxycarbonylalkylamino, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, bis- Alkylaminocarbonyl, Heteroarylalkoxy, Arylalkoxy A heterocyclic radical ( Heterocyclyl) contains at least one heterocyclic ring (=carbocyclic ring in which at least one carbon atom is replaced by a heteroatom, preferably by a heteroatom from the group N, O, S, P) which is saturated, unsaturated, partially saturated or heteroaromatic and can be unsubstituted or substituted, the binding site being localized on a ring atom. When the heterocyclyl radical or heterocyclic ring is optionally substituted, it may be fused to other carbocyclic or heterocyclic rings. In the case of optionally substituted heterocyclyl, polycyclic systems are also included, such as, for example, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[2.2.2]octanyl or 1-azabicyclo[2.2.1]heptyl. In the case of optionally substituted heterocyclyl, spirocyclic systems are also included, such as 1-oxa-5-azaspiro[2.3]hexyl. Unless defined otherwise, the heterocyclic ring preferably contains 3 to 9 ring atoms, in particular 3 to 6 ring atoms, and one or more, preferably 1 to 4, in particular 1, 2 or 3 heteroatoms im heterocyclic ring, preferably from the group N, O, and S, but not two oxygen atoms should be directly adjacent, such as with a heteroatom from the group N, O and S 1- or 2- or 3-pyrrolidinyl, 3,4 -dihydro-2H-pyrrol-2- or 3-yl, 2,3-dihydro-1H-pyrrol-1- or 2- or 3- or 4- or 5-yl; 2,5-dihydro-1H-pyrrole-1- or 2- or 3-yl, 1- or 2- or 3- or 4-piperidinyl; 2,3,4,5-tetrahydropyridin-2- or 3- or 4- or 5-yl or 6-yl; 1,2,3,6-tetrahydropyridin-1- or 2- or 3- or 4- or 5- or 6-yl; 1,2,3,4-tetrahydropyridin-1- or 2- or 3- or 4- or 5- or 6-yl; 1,4-dihydropyridin-1- or 2- or 3- or 4-yl; 2,3-dihydropyridin-2- or 3- or 4- or 5- or 6-yl; 2,5-dihydropyridine-2- or 3- or 4- or 5- or 6-yl, 1- or 2- or 3- or 4-azepanyl; 2,3,4,5-tetrahydro-1H-azepin-1- or 2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-tetrahydro-1H-azepin-1- or 2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-tetrahydro-1H-azepin-1- or 2- or 3- or 4-yl; 3,4,5,6-tetrahydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5-dihydro-1H-azepin-1- or 2- or 3- or 4-yl; 2,5-dihydro-1H-azepin-1- or -2- or 3- or 4- or 5- or 6- or 7-yl; 2,7-dihydro-1H-azepin-1- or -2- or 3- or 4-yl; 2,3-dihydro-1H-azepin-1- or -2- or 3- or 4- or 5- or 6- or 7-yl; 3,4-dihydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 3,6-dihydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 5,6-dihydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5-dihydro-3H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 1H-azepin-1- or -2- or 3- or 4- or 5- or 6- or 7-yl; 2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 3H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl, 2- or 3-oxolanyl (= 2- or 3-tetrahydrofuranyl); 2,3-dihydrofuran-2- or 3- or 4- or 5-yl; 2,5-dihydrofuran-2- or 3-yl, 2- or 3- or 4-oxanyl (= 2- or 3- or 4-tetrahydropyranyl); 3,4-dihydro-2H-pyran-2- or 3- or 4- or 5- or 6-yl; 3,6-dihydro-2H-pyran-2- or 3- or 4- or 5- or 6-yl; 2H-pyran-2- or 3- or 4- or 5- or 6-yl; 4H-pyran-2- or 3- or 4-yl, 2- or 3- or 4-oxepanyl; 2,3,4,5-tetrahydrooxepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-tetrahydrooxepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-tetrahydrooxepin-2- or 3- or 4-yl; 2,3-dihydrooxepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5-dihydrooxepin-2- or 3- or 4-yl; 2,5-dihydrooxepin-2- or 3- or 4- or 5- or 6- or 7-yl; oxepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2- or 3-tetrahydrothiophenyl; 2,3-dihydrothiophene-2- or 3- or 4- or 5-yl; 2,5-dihydrothiophen-2- or 3-yl; tetrahydro-2H-thiopyran-2- or 3- or 4-yl; 3,4-dihydro-2H-thiopyran-2- or 3- or 4- or 5- or 6-yl; 3,6-dihydro-2H-thiopyran-2- or 3- or 4- or 5- or 6-yl; 2H-thiopyran-2- or 3- or 4- or 5- or 6-yl; 4H-thiopyran-2- or 3- or 4-yl. Examples of preferred 3-ring and 4-ring heterocycles are 1- or 2-aziridinyl, oxiranyl, thiiranyl, 1- or 2- or 3-azetidinyl, 2- or 3-oxetanyl, 2- or 3-thietanyl, 1,3 -dioxetan-2-yl. Further examples of “heterocyclyl” are a partially or fully hydrogenated heterocyclic radical having two heteroatoms from the group N, O and S, such as 1- or 2- or 3- or 4-pyrazolidinyl; 4,5-dihydro-3H-pyrazol-3- or 4- or 5-yl; 4,5-dihydro-1H-pyrazol-1- or 3- or 4- or 5-yl; 2,3-dihydro-1H-pyrazol-1- or 2- or 3- or 4- or 5-yl; 1- or 2- or 3- or 4-imidazolidinyl; 2,3-dihydro-1H-imidazole-1- or 2- or 3- or 4-yl; 2,5-dihydro-1H-imidazol-1- or 2- or 4- or 5-yl; 4,5-dihydro-1H-imidazol-1- or 2- or 4- or 5-yl; hexahydropyridazin-1- or 2- or 3- or 4-yl; 1,2,3,4-tetrahydropyridazin-1- or 2- or 3- or 4- or 5- or 6-yl; 1,2,3,6-tetrahydropyridazin-1- or 2- or 3- or 4- or 5- or 6-yl; 1,4,5,6-tetrahydropyridazin-1- or 3- or 4- or 5- or 6-yl; 3,4,5,6-tetrahydropyridazin-3- or 4- or 5-yl; 4,5-dihydropyridazin-3- or 4-yl; 3,4-dihydropyridazin-3- or 4- or 5- or 6-yl; 3,6-dihydropyridazin-3- or 4-yl; 1,6-dihydropyriazin-1- or 3- or 4- or 5- or 6-yl; hexahydropyrimidin-1- or 2- or 3- or 4-yl; 1,4,5,6-tetrahydropyrimidin-1- or 2- or 4- or 5- or 6-yl; 1,2,5,6-tetrahydropyrimidin-1- or 2- or 4- or 5- or 6-yl; 1,2,3,4-tetrahydropyrimidin-1- or 2- or 3- or 4- or 5- or 6-yl; 1,6-dihydropyrimidin-1- or 2- or 4- or 5- or 6-yl; 1,2-dihydropyrimidin-1- or 2- or 4- or 5- or 6-yl; 2,5-dihydropyrimidin-2- or 4- or 5-yl; 4,5-dihydropyrimidin-4- or 5- or 6-yl; 1,4-dihydropyrimidin-1- or 2- or 4- or 5- or 6-yl; 1- or 2- or 3-piperazinyl; 1,2,3,6-tetrahydropyrazin-1- or 2- or 3- or 5- or 6-yl; 1,2,3,4-tetrahydropyrazin-1- or 2- or 3- or 4- or 5- or 6-yl; 1,2-dihydropyrazine-1- or 2- or 3- or 5- or 6-yl; 1,4-dihydropyrazin-1- or 2- or 3-yl; 2,3-dihydropyrazin-2- or 3- or 5- or 6-yl; 2,5-dihydropyrazin-2- or 3-yl; 1,3-dioxolan-2- or 4- or 5-yl; 1,3-dioxol-2- or 4-yl; 1,3-dioxan-2- or 4- or 5-yl; 4H-1,3-dioxin-2- or 4- or 5- or 6-yl; 1,4-dioxan-2- or 3- or 5- or 6-yl; 2,3-dihydro-1,4-dioxin-2- or 3- or 5- or 6-yl; 1,4-dioxin-2- or 3-yl; 1,2-dithiolan-3- or 4-yl; 3H-1,2-dithiol-3- or 4- or 5-yl; 1,3-dithiolan-2- or 4-yl; 1,3-dithiol-2- or 4-yl; 1,2-dithian-3- or 4-yl; 3,4-dihydro-1,2-dithiin-3- or 4- or 5- or 6-yl; 3,6-dihydro-1,2-dithiin-3- or 4-yl; 1,2-dithiin-3- or 4-yl; 1,3-dithian-2- or 4- or 5-yl; 4H-1,3-dithiin-2- or 4- or 5- or 6-yl; isoxazolidin-2- or 3- or 4- or 5-yl; 2,3-dihydroisoxazol-2- or 3- or 4- or 5-yl; 2,5-dihydroisoxazol-2- or 3- or 4- or 5-yl; 4,5-dihydroisoxazol-3- or 4- or 5-yl; 1,3-oxazolidin-2- or 3- or 4- or 5-yl; 2,3-dihydro-1,3-oxazol-2- or 3- or 4- or 5-yl; 2,5-dihydro-1,3-oxazol-2- or 4- or 5-yl; 4,5-dihydro-1,3-oxazol-2- or 4- or 5-yl; 1,2-oxazinan-2- or 3- or 4- or 5- or 6-yl; 3,4-dihydro-2H-1,2-oxazin-2- or 3- or 4- or 5- or 6-yl; 3,6-dihydro-2H-1,2-oxazin-2- or 3- or 4- or 5- or 6-yl; 5,6-dihydro-2H-1,2-oxazin-2- or 3- or 4- or 5- or 6-yl; 5,6-dihydro-4H-1,2-oxazin-3- or 4- or 5- or 6-yl; 2H-1,2-oxazin-2- or 3- or 4- or 5- or 6-yl; 6H-1,2-oxazin-3- or 4- or 5- or 6-yl; 4H-1,2-oxazin-3- or 4- or 5- or 6-yl; 1,3-oxazinan-2- or 3- or 4- or 5- or 6-yl; 3,4-dihydro-2H-1,3-oxazin-2- or 3- or 4- or 5- or 6-yl; 3,6-dihydro-2H-1,3-oxazin-2- or 3- or 4- or 5- or 6-yl; 5,6-dihydro-2H-1,3-oxazin-2- or 4- or 5- or 6-yl; 5,6-dihydro-4H-1,3-oxazin-2- or 4- or 5- or 6-yl; 2H-1,3-oxazin-2- or 4- or 5- or 6-yl; 6H-1,3-oxazin-2- or 4- or 5- or 6-yl; 4H-1,3-oxazin-2- or 4- or 5- or 6-yl; morpholin-2- or 3- or 4-yl; 3,4-dihydro-2H-1,4-oxazin-2- or 3- or 4- or 5- or 6-yl; 3,6-dihydro-2H-1,4-oxazin-2- or 3- or 5- or 6-yl; 2H-1,4-oxazin-2- or 3- or 5- or 6-yl; 4H-1,4-oxazin-2- or 3-yl; 1,2-oxazepan-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,5-tetrahydro-1,2-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-tetrahydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-Tetrahydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5,6,7-tetrahydro-1,2-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5,6,7-tetrahydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 2,3-dihydro-1,2-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5-dihydro-1,2-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,7-dihydro-1,2-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5-dihydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 4,7-dihydro-1,2-oxazepin-3- or 4- or 5- or 6- or 7-yl; 6,7-dihydro-1,2-oxazepin-3- or 4- or 5- or 6- or 7-yl; 1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 1,3-oxazepan-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,5-tetrahydro-1,3-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-tetrahydro-1,3-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-tetrahydro-1,3-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5,6,7-tetrahydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 4,5,6,7-tetrahydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 2,3-dihydro-1,3-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5-dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 2,7-dihydro-1,3-oxazepin-2- or 4- or 5- or 6- or 7-yl; 4,5-dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 4,7-dihydro-1,3-oxazepin-2- or 4- or 5- or 6- or 7-yl; 6,7-dihydro-1,3-oxazepin-2- or 4- or 5- or 6- or 7-yl; 1,3-oxazepin-2- or 4- or 5- or 6- or 7-yl; 1,4-oxazepan-2- or 3- or 5- or 6- or 7-yl; 2,3,4,5-Tetrahydro-1,4-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-tetrahydro-1,4-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-tetrahydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 2,5,6,7-tetrahydro-1,4-oxazepin-2- or 3- or 5- or 6- or 7-yl; 4,5,6,7-tetrahydro-1,4-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3-dihydro-1,4-oxazepin-2- or 3- or 5- or 6- or 7-yl; 2,5-dihydro-1,4-oxazepin-2- or 3- or 5- or 6- or 7-yl; 2,7-dihydro-1,4-oxazepin-2- or 3- or 5- or 6- or 7-yl; 4,5-dihydro-1,4-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4,7-dihydro-1,4-oxazepin-2- or 3- or 4- or 5- or 6- or 7-yl; 6,7-dihydro-1,4-oxazepin-2- or 3- or 5- or 6- or 7-yl; 1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; isothiazolidin-2- or 3- or 4- or 5-yl; 2,3-dihydroisothiazol-2- or 3- or 4- or 5-yl; 2,5-dihydroisothiazol-2- or 3- or 4- or 5-yl; 4,5-dihydroisothiazol-3- or 4- or 5-yl; 1,3-thiazolidin-2- or 3- or 4- or 5-yl; 2,3-dihydro-1,3-thiazol-2- or 3- or 4- or 5-yl; 2,5-dihydro-1,3-thiazol-2- or 4- or 5-yl; 4,5-dihydro-1,3-thiazol-2- or 4- or 5-yl; 1,3-thiazinan-2- or 3- or 4- or 5- or 6-yl; 3,4-dihydro-2H-1,3-thiazine-2- or 3- or 4- or 5- or 6-yl; 3,6-dihydro-2H-1,3-thiazine-2- or 3- or 4- or 5- or 6-yl; 5,6-dihydro-2H-1,3-thiazine-2- or 4- or 5- or 6-yl; 5,6-dihydro-4H-1,3-thiazine-2- or 4- or 5- or 6-yl; 2H-1,3-thiazine-2- or 4- or 5- or 6-yl; 6H-1,3-thiazine-2- or 4- or 5- or 6-yl; 4H-1,3-thiazine-2- or 4- or 5- or 6-yl. Further examples of “heterocyclyl” are a partially or fully hydrogenated heterocyclic radical with 3 heteroatoms from the group N, O and S, such as 1,4,2-dioxazolidin-2- or 3- or 5-yl; 1,4,2-dioxazol-3- or 5-yl; 1,4,2-dioxazinan-2- or -3- or 5- or 6-yl; 5,6-dihydro-1,4,2-dioxazin-3- or 5- or 6-yl; 1,4,2-dioxazin-3- or 5- or 6-yl; 1,4,2-dioxazepan-2- or 3- or 5- or 6- or 7-yl; 6,7-dihydro-5H-1,4,2-dioxazepin-3- or 5- or 6- or 7-yl; 2,3-dihydro-7H-1,4,2-dioxazepine-2- or 3- or 5- or 6- or 7-yl; 2,3-dihydro-5H-1,4,2-dioxazepine-2- or 3- or 5- or 6- or 7-yl; 5H-1,4,2-dioxazepin-3- or 5- or 6- or 7-yl; 7H-1,4,2-dioxazepin-3- or 5- or 6- or 7-yl. Structural examples of optionally further substituted heterocycles are also listed below: C
Figure imgf000088_0001
? ( 4 >( &
Figure imgf000089_0001
( 2 I f 0 •
Figure imgf000090_0001
Die oben aufgeführten Heterocyclen sind bevorzugt beispielsweise durch Wasserstoff, Halogen, Alkyl, Haloalkyl, Hydroxy, Alkoxy, Cycloalkoxy, Aryloxy, Alkoxyalkyl, Alkoxyalkoxy, Cycloalkyl, Halocycloalkyl, Aryl, Arylalkyl, Heteroaryl, Heterocyclyl, Alkenyl, Alkylcarbonyl, Cycloalkylcarbonyl, Arylcarbonyl, Heteroarylcarbonyl, Alkoxycarbonyl, Hydroxycarbonyl, Cycloalkoxycarbonyl, Cycloalkylalkoxycarbonyl, Alkoxycarbonylalkyl, Arylalkoxycarbonyl, Arylalkoxycarbonylalkyl, Alkinyl, Alkinylalkyl, Alkylalkinyl, Tris-alkylsilylalkinyl, Nitro, Amino, Cyano, Haloalkoxy, Haloalkylthio, Alkylthio, Hydrothio, Hydroxyalkyl, Oxo, Heteroarylalkoxy, Arylalkoxy, Heterocyclylalkoxy, Heterocyclylalkylthio, Heterocyclyloxy, Heterocyclylthio, Heteroaryloxy, Bis- alkylamino, Alkylamino, Cycloalkylamino, Hydroxycarbonylalkylamino, Alkoxycarbonylalkylamino, Arylalkoxycarbonylalkylamino, Alkoxycarbonylalkyl(alkyl)amino, Aminocarbonyl, Alkylaminocarbonyl, Bis-alkylaminocarbonyl, Cycloalkylaminocarbonyl, Hydroxycarbonylalkylaminocarbonyl, Alkoxycarbonylalkylaminocarbonyl, Arylalkoxycarbonylalkylaminocarbonyl substituiert. Wenn ein Grundkörper "durch einen oder mehrere Reste" aus einer Aufzählung von Resten (= Gruppe) oder einer generisch definierten Gruppe von Resten substituiert ist, so schließt dies jeweils die gleichzeitige Substitution durch mehrere gleiche und/oder strukturell unterschiedliche Reste ein. Handelt es sich es sich um einen teilweise oder vollständig gesättigten Stickstoff-Heterocyclus, so kann dieser sowohl über Kohlenstoff als auch über den Stickstoff mit dem Rest des Moleküls verknüpft sein. Als Substituenten für einen substituierten heterocyclischen Rest kommen die weiter unten genannten Substituenten in Frage, zusätzlich auch Oxo und Thioxo. Die Oxogruppe als Substituent an einem Ring- C-Atom bedeutet dann beispielsweise eine Carbonylgruppe im heterocyclischen Ring. Dadurch sind vorzugsweise auch Lactone und Lactame umfasst. Die Oxogruppe kann auch an den Heteroringatomen, die in verschiedenen Oxidationsstufen existieren können, z.B. bei N und S, auftreten und bilden dann beispielsweise die divalenten Gruppen N(O), S(O) (auch kurz SO) und S(O)2 (auch kurz SO2) im heterocyclischen Ring. Im Fall von –N(O)- und –S(O)-Gruppen sind jeweils beide Enantiomere umfasst. Erfindungsgemäß steht der Ausdruck „Heteroaryl“ für heteroaromatische Verbindungen, d. h. vollständig ungesättigte aromatische heterocyclische Verbindungen, vorzugsweise für 5- bis 7-gliedrige Ringe mit 1 bis 4, vorzugsweise 1 oder 2 gleichen oder verschiedenen Heteroatomen, vorzugsweise O, S oder N. Erfindungsgemäße Heteroaryle sind beispielsweise 1H-Pyrrol-1-yl; 1H-Pyrrol-2-yl; 1H-Pyrrol- 3-yl; Furan-2-yl; Furan-3-yl; Thien-2-yl; Thien-3-yl, 1H-Imidazol-1-yl; 1H-Imidazol-2-yl; 1H-Imidazol- 4-yl; 1H-Imidazol-5-yl; 1H-Pyrazol-1-yl; 1H-Pyrazol-3-yl; 1H-Pyrazol-4-yl; 1H-Pyrazol-5-yl, 1H-1,2,3- Triazol-1-yl, 1H-1,2,3-Triazol-4-yl, 1H-1,2,3-Triazol-5-yl, 2H-1,2,3-Triazol-2-yl, 2H-1,2,3-Triazol-4-yl, 1H-1,2,4-Triazol-1-yl, 1H-1,2,4-Triazol-3-yl, 4H-1,2,4-Triazol-4-yl, 1,2,4-Oxadiazol-3-yl, 1,2,4- Oxadiazol-5-yl, 1,3,4-Oxadiazol-2-yl, 1,2,3-Oxadiazol-4-yl, 1,2,3-Oxadiazol-5-yl, 1,2,5-Oxadiazol-3-yl, Azepinyl, Pyridin-2-yl, Pyridin-3-yl, Pyridin-4-yl, Pyrazin-2-yl, Pyrazin-3-yl, Pyrimidin-2-yl, Pyrimidin-4-yl, Pyrimidin-5-yl, Pyridazin-3-yl, Pyridazin-4-yl, 1,3,5-Triazin-2-yl, 1,2,4-Triazin-3-yl, 1,2,4-Triazin-5-yl, 1,2,4-Triazin-6-yl, 1,2,3-Triazin-4-yl, 1,2,3-Triazin-5-yl, 1,2,4-, 1,3,2-, 1,3,6- und 1,2,6-Oxazinyl, Isoxazol-3-yl, Isoxazol-4-yl, Isoxazol-5-yl, 1,3-Oxazol-2-yl, 1,3-Oxazol-4-yl, 1,3- Oxazol-5-yl, Isothiazol-3-yl, Isothiazol-4-yl, Isothiazol-5-yl, 1,3-Thiazol-2-yl, 1,3-Thiazol-4-yl, 1,3- Thiazol-5-yl, Oxepinyl, Thiepinyl, 1,2,4-Triazolonyl und 1,2,4-Diazepinyl, 2H-1,2,3,4-Tetrazol-5-yl, 1H-1,2,3,4-Tetrazol-5-yl, 1,2,3,4-Oxatriazol-5-yl, 1,2,3,4-Thiatriazol-5-yl, 1,2,3,5-Oxatriazol-4-yl, 1,2,3,5-Thiatriazol-4-yl. Die erfindungsgemäßen Heteroarylgruppen können ferner mit einem oder mehreren, gleichen oder verschiedenen Resten substituiert sein. Sind zwei benachbarte Kohlenstoffatome Bestandteil eines weiteren aromatischen Rings, so handelt es sich um annellierte heteroaromatische Systeme, wie benzokondensierte oder mehrfach annellierte Heteroaromaten. Bevorzugt sind beispielsweise Chinoline (z. B. Chinolin-2-yl, Chinolin-3-yl, Chinolin-4-yl, Chinolin-5- yl, Chinolin-6-yl, Chinolin-7-yl, Chinolin-8-yl); Isochinoline (z. B. Isochinolin-1-yl, Isochinolin-3-yl, Isochinolin-4-yl, Isochinolin-5-yl, Isochinolin-6-yl, Isochinolin-7-yl, Isochinolin-8-yl); Chinoxalin; Chinazolin; Cinnolin; 1,5-Naphthyridin; 1,6-Naphthyridin; 1,7-Naphthyridin; 1,8-Naphthyridin; 2,6- Naphthyridin; 2,7-Naphthyridin; Phthalazin; Pyridopyrazine; Pyridopyrimidine; Pyridopyridazine; Pteridine; Pyrimidopyrimidine. Beispiele für Heteroaryl sind auch 5- oder 6-gliedrige benzokondensierte Ringe aus der Gruppe 1H-Indol-1-yl, 1H-Indol-2-yl, 1H-Indol-3-yl, 1H-Indol-4-yl, 1H-Indol-5-yl, 1H- Indol-6-yl, 1H-Indol-7-yl, 1-Benzofuran-2-yl, 1-Benzofuran-3-yl, 1-Benzofuran-4-yl, 1-Benzofuran-5- yl, 1-Benzofuran-6-yl, 1-Benzofuran-7-yl, 1-Benzothiophen-2-yl, 1-Benzothiophen-3-yl, 1- Benzothiophen-4-yl, 1-Benzothiophen-5-yl, 1-Benzothiophen-6-yl, 1-Benzothiophen-7-yl, 1H-Indazol- 1-yl, 1H-Indazol-3-yl, 1H-Indazol-4-yl, 1H-Indazol-5-yl, 1H-Indazol-6-yl, 1H-Indazol-7-yl, 2H-Indazol- 2-yl, 2H-Indazol-3-yl, 2H-Indazol-4-yl, 2H-Indazol-5-yl, 2H-Indazol-6-yl, 2H-Indazol-7-yl, 2H- Isoindol-2-yl, 2H-Isoindol-1-yl, 2H-Isoindol-3-yl, 2H-Isoindol-4-yl, 2H-Isoindol-5-yl, 2H-Isoindol-6-yl; 2H-Isoindol-7-yl, 1H-Benzimidazol-1-yl, 1H-Benzimidazol-2-yl, 1H-Benzimidazol-4-yl, 1H- Benzimidazol-5-yl, 1H-Benzimidazol-6-yl, 1H-Benzimidazol-7-yl, 1,3-Benzoxazol-2-yl, 1,3- Benzoxazol-4-yl, 1,3-Benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-Benzoxazol-7-yl, 1,3-Benzthiazol-2-yl, 1,3-Benzthiazol-4-yl, 1,3-Benzthiazol-5-yl, 1,3-Benzthiazol-6-yl, 1,3-Benzthiazol-7-yl, 1,2- Benzisoxazol-3-yl, 1,2-Benzisoxazol-4-yl, 1,2-Benzisoxazol-5-yl, 1,2-Benzisoxazol-6-yl, 1,2- Benzisoxazol-7-yl, 1,2-Benzisothiazol-3-yl, 1,2-Benzisothiazol-4-yl, 1,2-Benzisothiazol-5-yl, 1,2- Benzisothiazol-6-yl, 1,2-Benzisothiazol-7-yl. Die Bezeichnung "Halogen" bedeutet beispielsweise Fluor, Chlor, Brom oder Iod. Wird die Bezeichnung für einen Rest verwendet, dann bedeutet "Halogen" beispielsweise ein Fluor-, Chlor-, Brom- oder Iodatom. Erfindungsgemäß bedeutet „Alkyl“ einen geradkettigen oder verzweigten offenkettigen, gesättigten Kohlenwasserstoffrest, der gegebenenfalls ein- oder mehrfach substituiert ist und im letzteren Falle als „substituiertes Alkyl“ bezeichnet wird. Bevorzugte Substituenten sind Halogenatome, Alkoxy-, Haloalkoxy-, Cyano-, Alkylthio, Haloalkylthio-, Amino- oder Nitrogruppen, besonders bevorzugt sind Methoxy, Methyl, Fluoralkyl, Cyano, Nitro, Fluor, Chlor, Brom oder Iod. Die Vorsilbe „Bis“ schließt auch die Kombination unterschiedlicher Alkylreste ein, z. B. Methyl(Ethyl) oder Ethyl(Methyl). „Haloalkyl“, „-alkenyl“ und „-alkinyl“ bedeuten durch gleiche oder verschiedene Halogenatome, teilweise oder vollständig substituiertes Alkyl, Alkenyl bzw. Alkinyl, z.B. Monohaloalkyl (= Monohalogenalkyl) wie z. B. CH2CH2Cl, CH2CH2Br, CHClCH3, CH2Cl, CH2F; Perhaloalkyl wie z. B. CCl3, CClF2, CFCl2,CF2CClF2, CF2CClFCF3; Polyhaloalkyl wie z. B. CH2CHFCl, CF2CClFH, CF2CBrFH, CH2CF3; Der Begriff Perhaloalkyl umfasst dabei auch den Begriff Perfluoralkyl. „Teilfluoriertes Alkyl“ bedeutet einen geradkettigen oder verzweigten, gesättigten Kohlenwasserstoff, der einfach oder mehrfach durch Fluor substituiert ist, wobei sich die entsprechenden Fluoratome als Substituenten an einem oder mehreren verschiedenen Kohlenstoffatomen der geradkettigen oder verzweigten Kohlenwasserstoffkette befinden können, wie z. B. CHFCH3, CH2CH2F, CH2CH2CF3, CHF2, CH2F, CHFCF2CF3 „Teilfluoriertes Haloalkyl“ bedeutet einen geradkettigen oder verzweigten, gesättigten Kohlenwasserstoff, der durch verschiedene Halogenatome mit mindestens einem Fluoratom substituiert ist, wobei alle anderen gegebenenfalls vorhandenen Halogenatome ausgewählt sind aus der Gruppe Fluor, Chlor oder Brom, Iod. Die entsprechenden Halogenatome können sich dabei als Substituenten an einem oder mehreren verschiedenen Kohlenstoffatomen der geradkettigen oder verzweigten Kohlenwasserstoffkette befinden. Teilfluoriertes Haloalkyl schließt auch die vollständige Substitution der geradkettigen oder verzweigten Kette durch Halogen unter Beteiligung von mindestens einem Fluoratom ein. „Haloalkoxy“ ist z.B. OCF3, OCHF2, OCH2F, OCF2CF3, OCH2CF3 und OCH2CH2Cl; Entsprechendes gilt für Haloalkenyl und andere durch Halogen substituierten Reste. Der hier beispielhaft genannte Ausdruck "(C1-C4)-Alkyl" bedeutet eine Kurzschreibweise für geradkettiges oder verzweigtes Alkyl mit einem bis 4 Kohlenstoffatomen entsprechend der Bereichsangabe für C-Atome, d. h. umfasst die Reste Methyl, Ethyl, 1-Propyl, 2-Propyl, 1-Butyl, 2-Butyl, 2-Methylpropyl oder tert-Butyl. Allgemeine Alkylreste mit einem größeren angegebenen Bereich von C-Atomen, z. B. "(C1-C6)-Alkyl", umfassen entsprechend auch geradkettige oder verzweigte Alkylreste mit einer größeren Zahl von C-Atomen, d. h. gemäß Beispiel auch die Alkylreste mit 5 und 6 C-Atomen. Wenn nicht speziell angegeben, sind bei den Kohlenwasserstoffresten wie Alkyl-, Alkenyl- und Alkinylresten, auch in zusammengesetzten Resten, die niederen Kohlenstoffgerüste, z.B. mit 1 bis 6 C-Atomen bzw. bei ungesättigten Gruppen mit 2 bis 6 C-Atomen, bevorzugt. Alkylreste, auch in den zusammengesetzten Resten wie Alkoxy, Haloalkyl usw., bedeuten z.B. Methyl, Ethyl, n- oder i-Propyl, n-, i-, t- oder 2-Butyl, Pentyle, Hexyle, wie n-Hexyl, i-Hexyl und 1,3-Dimethylbutyl, Heptyle, wie n-Heptyl, 1-Methylhexyl und 1,4-Dimethylpentyl; Alkenyl- und Alkinylreste haben die Bedeutung der den Alkylresten entsprechenden möglichen ungesättigten Reste, wobei mindestens eine Doppelbindung bzw. Dreifachbindung enthalten ist. Bevorzugt sind Reste mit einer Doppelbindung bzw. Dreifachbindung. Der Begriff „Alkenyl“ schließt insbesondere auch geradkettige oder verzweigte offenkettige Kohlenwasserstoffreste mit mehr als einer Doppelbindung ein, wie 1,3-Butadienyl und 1,4-Pentadienyl, aber auch Allenyl- oder Kumulenyl-reste mit einer bzw. mehreren kumulierten Doppelbindungen, wie beispielsweise Allenyl (1,2-Propadienyl), 1,2-Butadienyl und 1,2,3-Pentatrienyl. Alkenyl bedeutet z.B. Vinyl, welches ggf. durch weitere Alkylreste substituiert sein kann, z B. (aber nicht beschränkt auf) (C2-C6)-Alkenyl wie Ethenyl, 1-Propenyl, 2-Propenyl, 1-Methylethenyl, 1-Butenyl, 2-Butenyl, 3- Butenyl, 1-Methyl-1-propenyl, 2-Methyl-1-propenyl, 1-Methyl-2-propenyl, 2-Methyl-2-propenyl, 1- Pentenyl, 2-Pentenyl, 3-Pentenyl, 4-Pentenyl, 1-Methyl-1-butenyl, 2-Methyl-1-butenyl, 3-Methyl-1- butenyl, 1-Methyl-2-butenyl, 2-Methyl-2-butenyl, 3-Methyl-2-butenyl, 1-Methyl-3-butenyl, 2-Methyl-3- butenyl, 3-Methyl-3-butenyl, 1,1-Dimethyl-2-propenyl, 1,2-Dimethyl-1-propenyl, 1,2-Dimethyl-2- propenyl, 1-Ethyl-1-propenyl, 1-Ethyl-2-propenyl, 1-Hexenyl, 2-Hexenyl, 3-Hexenyl, 4-Hexenyl, 5- Hexenyl, 1-Methyl-1-pentenyl, 2-Methyl-1-pentenyl, 3-Methyl-1-pentenyl, 4-Methyl-1-pentenyl, 1- Methyl-2-pentenyl, 2-Methyl-2-pentenyl, 3-Methyl-2-pentenyl, 4-Methyl-2-pentenyl, 1-Methyl-3- pentenyl, 2-Methyl-3-pentenyl, 3-Methyl-3-pentenyl, 4-Methyl-3-pentenyl, 1-Methyl-4-pentenyl, 2- Methyl-4-pentenyl, 3-Methyl-4-pentenyl, 4-Methyl-4-pentenyl, 1,1-Dimethyl-2-butenyl, 1,1-Dimethyl- 3-butenyl, 1,2-Dimethyl-1-butenyl, 1,2-Dimethyl-2-butenyl, 1,2-Dimethyl-3-butenyl, 1,3-Dimethyl-1- butenyl, 1,3-Dimethyl-2-butenyl, 1,3-Dimethyl-3-butenyl, 2,2-Dimethyl-3-butenyl, 2,3-Dimethyl-1- butenyl, 2,3-Dimethyl-2-butenyl, 2,3-Dimethyl-3-butenyl, 3,3-Dimethyl-1-butenyl, 3,3-Dimethyl-2- butenyl, 1-Ethyl-1-butenyl, 1-Ethyl-2-butenyl, 1-Ethyl-3-butenyl, 2-Ethyl-1-butenyl, 2-Ethyl-2-butenyl, 2-Ethyl-3-butenyl, 1,1,2-Trimethyl-2-propenyl, 1-Ethyl-1-methyl-2-propenyl, 1-Ethyl-2-methyl-1- propenyl und 1-Ethyl-2-methyl-2-propenyl. Der Begriff „Alkinyl“ schließt insbesondere auch geradkettige oder verzweigte offenkettige Kohlenwasserstoffreste mit mehr als einer Dreifachbindung oder auch mit einer oder mehreren Dreifachbindungen und einer oder mehreren Doppelbindungen ein, wie beispielsweise 1,3-Butatrienyl bzw.3-Penten-1-in-1-yl. (C2-C6)-Alkinyl bedeutet z.B. Ethinyl, 1-Propinyl, 2-Propinyl, 1-Butinyl, 2- Butinyl, 3-Butinyl, 1-Methyl-2-propinyl, 1-Pentinyl, 2-Pentinyl, 3-Pentinyl, 4-Pentinyl, 1-Methyl-2- butinyl, 1-Methyl-3-butinyl, 2-Methyl-3-butinyl, 3-Methyl-1-butinyl, 1,1-Dimethyl-2-propinyl, 1-Ethyl- 2-propinyl, 1-Hexinyl, 2-Hexinyl, 3-Hexinyl, 4-Hexinyl, 5-Hexinyl, 1-Methyl-2-pentinyl, 1-Methyl-3- pentinyl, 1-Methyl-4-pentinyl, 2-Methyl-3-pentinyl, 2-Methyl-4-pentinyl, 3-Methyl-1-pentinyl, 3- Methyl-4-pentinyl, 4-Methyl-1-pentinyl, 4-Methyl-2-pentinyl, 1,1-Di-methyl-2-butinyl, 1,1-Dimethyl-3- butinyl, 1,2-Dimethyl-3-butinyl, 2,2-Dimethyl-3-butinyl, 3,3-Dimethyl-1-butinyl, 1-Ethyl-2-butinyl, 1- Ethyl-3-butinyl, 2-Ethyl-3-butinyl und 1-Ethyl-1-methyl-2-propinyl. Der Begriff „Cycloalkyl“ bedeutet ein carbocyclisches, gesättigtes Ringsystem mit vorzugsweise 3-8 Ring-C-Atomen, z.B. Cyclopropyl, Cyclobutyl, Cyclopentyl oder Cyclohexyl, das gegebenenfalls weiter substituiert ist, bevorzugt durch Wasserstoff, Alkyl, Alkoxy, Cyano, Nitro, Alkylthio, Haloalkylthio, Halogen, Alkenyl, Alkinyl, Haloalkyl, AMino, Alkylamino, Bisalkylamino, Alkocycarbonyl, Hydroxycarbonyl, Arylalkoxycarbonyl, Aminocarbonyl, Alkylaminocarbonyl, Cycloalkylaminocarbonyl. Im Falle von gegebenenfalls substituiertem Cycloalkyl werden cyclische Systeme mit Substituenten umfasst, wobei auch Substituenten mit einer Doppelbindung am Cycloalkylrest, z. B. eine Alkylidengruppe wie Methyliden, umfasst sind. Im Falle von gegebenenfalls substituiertem Cycloalkyl werden auch mehrcyclische aliphatische Systeme umfasst, wie beispielsweise Bicyclo[1.1.0]butan-1-yl, Bicyclo[1.1.0]butan-2-yl, Bicyclo[2.1.0]pentan-1-yl, Bicyclo[1.1.1]pentan-1- yl, Bicyclo[2.1.0]pentan-2-yl, Bicyclo[2.1.0]pentan-5-yl, Bicyclo[2.1.1]hexyl, Bicyclo[2.2.1]hept-2-yl, Bicyclo[2.2.2]octan-2-yl, Bicyclo[3.2.1]octan-2-yl, Bicyclo[3.2.2]nonan-2-yl, Adamantan-1-yl und Adamantan-2-yl, aber auch Systeme wie z. B.1,1'-Bi(cyclopropyl)-1-yl, 1,1'-Bi(cyclopropyl)-2-yl. Der Ausdruck "(C3-C7)-Cycloalkyl" bedeutet eine Kurzschreibweise für Cycloalkyl mit drei bis 7 Kohlenstoffatomen entsprechend der Bereichsangabe für C-Atome. Im Falle von substituiertem Cycloalkyl werden auch spirocyclische aliphatische Systeme umfasst, wie beispielsweise Spiro[2.2]pent-1-yl, Spiro[2.3]hex-1-yl, Spiro[2.3]hex-4-yl, 3-Spiro[2.3]hex-5-yl, Spiro[3.3]hept-1-yl, Spiro[3.3]hept-2-yl. „Cycloalkenyl“ bedeutet ein carbocyclisches, nicht aromatisches, partiell ungesättigtes Ringsystem mit vorzugsweise 4-8 C-Atomen, z.B.1-Cyclobutenyl, 2-Cyclobutenyl, 1-Cyclopentenyl, 2-Cyclopentenyl, 3-Cyclopentenyl, oder 1-Cyclohexenyl, 2-Cyclohexenyl, 3-Cyclohexenyl, 1,3-Cyclohexadienyl oder 1,4-Cyclohexadienyl, wobei auch Substituenten mit einer Doppelbindung am Cycloalkenylrest, z. B. eine Alkylidengruppe wie Methyliden, umfasst sind. Im Falle von gegebenenfalls substituiertem Cycloalkenyl gelten die Erläuterungen für substituiertes Cycloalkyl entsprechend. Der Begriff „Alkyliden“, z. B. auch in der Form (C1-C10)-Alkyliden, bedeutet den Rest eines geradkettigen oder verzweigten offenkettigen Kohlenwasserstoffrests, der über eine Zweifachbindung gebunden ist. Als Bindungsstelle für Alkyliden kommen naturgemäß nur Positionen am Grundkörper in Frage, an denen zwei H-Atome durch die Doppelbindung ersetzt werden können; Reste sind z. B. =CH2, =CH-CH3, =C(CH3)-CH3, =C(CH3)-C2H5 oder =C(C2H5)-C2H5. Cycloalkyliden bedeutet ein carbocyclischer Rest, der über eine Zweifachbindung gebunden ist. „Cycloalkylalkyloxy“ bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkylalkylrest und „Arylalkyloxy“ bedeutet ein über ein Sauerstoffatom gebundenen Arylalkylrest. „Alkoxyalkyl“ steht für einen über eine Alkylgruppe gebundenen Alkoxyrest und „Alkoxyalkoxy“ bedeutet einen über ein Sauerstoffatom gebundenen Alkoxyalkylrest, z.B. (aber nicht beschränkt auf) Methoxymethoxy, Methoxyethoxy, Ethoxyethoxy, Methoxy-n-propyloxy. „Alkylthioalkyl“ steht für einen über eine Alkylgruppe gebundenen Alkylthiorest und „Alkylthioalkylthio“ bedeutet einen über ein Sauerstoffatom gebundenen Alkylthioalkylrest. „Arylalkoxyalkyl“ steht für einen über eine Alkylgruppe gebundenen Aryloxyrest und „Heteroaryloxyalkyl“ bedeutet einen über eine Alkylgruppe gebundenen Heteroaryloxyrest. „Haloalkoxyalkyl“ steht für einen gebundenen Haloalkoxyrest und „Haloalkylthioalkyl“ bedeutet einen über eine Alkylgruppe gebundenen Haloalkylthiorest. „Arylalkyl“ steht für einen über eine Alkylgruppe gebundenen Arylrest, „Heteroarylalkyl“ bedeutet einen über eine Alkylgruppe gebundenen Heteroarylrest, und „Heterocyclylalkyl“ bedeutet einen über eine Alkylgruppe gebundenen Heterocyclylrest. „Cycloalkylalkyl“ steht für einen über eine Alkylgruppe gebundenen Cycloalkylrest, z. B. (aber nicht beschränkt auf) Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, 1- Cyclopropyleth-1-yl, 2-Cyclopropyleth-1-yl, 1-Cyclopropylprop-1-yl, 3-Cyclopropylprop-1-yl. „Arylalkenyl“ steht für einen über eine Alkenylgruppe gebundenen Arylrest, „Heteroarylalkenyl“ bedeutet einen über eine Alkenylgruppe gebundenen Heteroarylrest, und „Heterocyclylalkenyl“ bedeutet einen über eine Alkenylgruppe gebundenen Heterocyclylrest. „Arylalkinyl“ steht für einen über eine Alkinylgruppe gebundenen Arylrest, „Heteroarylalkinyl“ bedeutet einen über eine Alkinylgruppe gebundenen Heteroarylrest, und „Heterocyclylalkinyl“ bedeutet einen über eine Alkinylgruppe gebundenen Heterocyclylrest. Erfindungsgemäß steht "Haloalkylthio" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes S-Halogenalkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, wie (C1-C8)-, (C1-C6)- oder (C1-C4)-Haloalkylthio, z.B. (aber nicht beschränkt auf) Trifluormethylthio, Pentafluorethylthio, Difluormethyl, 2,2-Difluoreth-1-ylthio, 2,2,2-Difluoreth-1- ylthio, 3,3,3-prop-1-ylthio. „Halocycloalkyl“ und „Halocycloalkenyl“ bedeuten durch gleiche oder verschiedene Halogenatome, wie z. B. F, Cl und Br, oder durch Haloalkyl, wie z. B. Trifluormethyl oder Difluormethyl teilweise oder vollständig substituiertes Cycloalkyl oder Cycloalkenyl , z.B.1-Fluorcycloprop-1-yl, 2-Fluorcycloprop- 1-yl, 2,2-Difluorcycloprop-1-yl, 1-Fluorcyclobut-1-yl, 1-Trifluormethylcycloprop-1-yl, 2- Trifluormethylcycloprop-1-yl, 1-Chlor-cycloprop-1-yl, 2-Chlorcycloprop-1-yl, 2,2-Dichlorcycloprop-1- yl, 3,3-Difluorcyclobutyl, Erfindungsgemäß steht "Trialkylsilyl" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes Si-Alkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, wie Tri-[(C1-C8)-, (C1-C6)- oder (C1-C4)-alkyl]silyl, z.B. (aber nicht beschränkt auf) Trimethylsilyl, Triethylsilyl, Tri-(n-propyl)silyl, Tri-(iso-propyl)silyl, Tri-(n-butyl)silyl, Tri-(1- methylprop-1-yl)silyl, Tri-(2-methylprop-1-yl)silyl, Tri(1,1-Dimethyleth-1-yl)silyl, Tri(2,2- Dimethyleth-1-yl)silyl. „Trialkylsilylalkinyl“ steht für einen über eine Alkinylgruppe gebundenen Trialkylsilylrest. Wenn die Verbindungen durch Wasserstoffverschiebung Tautomere bilden können, welche strukturell formal nicht durch die Formel (I) erfasst würden, so sind diese Tautomere gleichwohl von der Definition der erfindungsgemäßen Verbindungen der Formel (I) umfasst, sofern nicht ein bestimmtes Tautomer Gegenstand der Betrachtung ist. So können beispielsweise viele Carbonylverbindungen sowohl in der Ketoform wie auch in der Enolform vorliegen, wobei beide Formen durch die Definition der Verbindung der Formel (I) umfasst werden. Die Verbindungen der allgemeinen Formel (I) können je nach Art und Verknüpfung der Substituenten als Stereoisomere vorliegen. Die durch ihre spezifische Raumform definierten möglichen Stereoisomere, wie Enantiomere, Diastereomere, Z- und E-Isomere sind alle von der Formel (I) umfasst. Sind beispielsweise eine oder mehrere Alkenylgruppen vorhanden, so können Diastereomere (Z- und E- Isomere) auftreten. Sind beispielsweise ein oder mehrere asymmetrische Kohlenstoffatome vorhanden, so können Enantiomere und Diastereomere auftreten. Stereoisomere lassen sich aus den bei der Herstellung anfallenden Gemischen nach üblichen Trennmethoden erhalten. Die chromatographische Trennung kann sowohl im analytischen Maßstab zur Feststellung des Enantiomerenüberschusses bzw. des Diastereomerenüberschusses, wie auch im präparativen Maßstab zur Herstellung von Prüfmustern für die biologische Ausprüfung erfolgen. Ebenso können Stereoisomere durch Einsatz stereoselektiver Reaktionen unter Verwendung optisch aktiver Ausgangs- und/oder Hilfsstoffe selektiv hergestellt werden. Die Erfindung betrifft somit auch alle Stereoisomeren, die von der allgemeinen Formel (I) umfasst, jedoch nicht mit ihrer spezifischen Stereoform angegeben sind, sowie deren Gemische. Sofern die Verbindungen als Feststoffe erhalten werden, kann die Reinigung auch durch Umkristallisieren oder Digerieren erfolgen. Sofern einzelne Verbindungen (I) nicht auf den nachstehend beschriebenen Wegen zufriedenstellend zugänglich sind, können sie durch Derivatisierung anderer Verbindungen (I) hergestellt werden. Als Isolierungs-, Reinigungs- und Stereoisomerenauftrennungsverfahren von Verbindungen der Formel (I) kommen Methoden in Frage, die dem Fachmann aus analogen Fällen allgemein bekannt sind, z.B. durch physikalische Verfahren wie Kristallisation, Chromatographieverfahren, vor allem Säulenchromatographie und HPLC (Hochdruckflüssigchromatographie), Destillation, gegebenenfalls unter reduziertem Druck, Extraktion und andere Verfahren, können gegebenenfalls verbleibende Gemische in der Regel durch chromatographische Trennung, z.B. an chiralen Festphasen, getrennt werden. Für präparative Mengen oder im industriellen Maßstab kommen Verfahren in Frage wie Kristallisation, z.B. diastereomerer Salze, die aus den Diastereomerengemischen mit optisch aktiven Säuren und gegebenenfalls bei vorhandenen sauren Gruppen mit optisch aktiven Basen erhalten werden können. Synthese Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) können über verschiedene literaturbeschriebene Synthesewege ausgehend von kommerziell verfügbaren oder leicht herstellbaren Ausgangssubstanzen hergestellt werden. Die substituierten Pyrrolidinone der allgemeinen Formel (I.1) können mit Hilfe einer literaturbeschriebenen Synthese (J. Org. Chem.1950, 2727) durch Umsetzung einer geeigneten, gegebenenfalls weiter substituierten trans-Hexendisäure mit einem geeigneten, gegebenenfalls weiter substituierten Amin, bevorzugt einem Benzyl- oder Heteroarylmethylamin, bei erhöhter Temperatur in einem geeigneten polar-protischen Lösemittel (z.B. Wasser oder Essigsäure) hergestellt werden (Schema 1). Die Ringschlussreaktion wurde dabei in einem geeigneten abgeschlossenen Gefäß unter Mikrowellenbedingungen durchgeführt. Im nachfolgenden Syntheseschema 1 haben die Gruppen R1, R3, R4, R5, R6, R13, R14, R15, R35, R36 der allgemeinen Formel (I.1) die weiter oben beschriebenen Definitionen, während R7 beispielhaft, aber nicht einschränkend für Wasserstoff steht. I
Figure imgf000098_0001
Schema 1. Das aus der Ringschlussreaktion hervorgehende Pyrrolidinon (I.1a) kann danach mit Hilfe geeigneter Kupplungsreagenzien [z.B.1-Ethyl-3-(3-dimethylaminopropyl)carbodiimid (EDC), 2,4,6-Tripropyl- 1,3,5,2λ5,4λ5,6λ5-trioxatriphosphinan-2,4,6-trioxid (T3P), Hydroxybenzotriazol (HOBt)] unter Verwendung einer geeigneten Base (z.B. Triethylamin oder Diisopropylethylamin) in einem geeigneten polar-aprotischen Lösemittel (z.B. Dichlormethan) in die entsprechenden Ester (I.1b) oder Amide (I.1c) überführt werden. Alternativ können Oxopyrrolidinylesigsäureester (I.1d) mit Hilfe einer zweistufigen Kettenverlängerung aus den entsprechenden Oxopyrrolidinylcarboxylaten (C), hergestellt werden. Dabei wird zuerst der betreffende Carbonsäureester (C) mit Hilfe eines geeigneten Reduktionsmittels (z. B. Natrium oder Lithiumborhydrid) in den intermediären Alkohol (D) überführt, der danach mit Triethylphosphonoacetat und einer geeigneten Base, z.B. Natriumhydrid zum gewünschte Zielprodukt (I.1d) reagiert (Chemistry - A European Journal (2017), 23, 7428-7432I). Im folgenden Schema 2 sind die Reste R13 und R14 beispielhaft, aber nicht einschränkend durch Wasserstoff dargestellt, während R1, R3, R4, R5, R6 und R36 die weiter oben beschriebenen Bedeutungen haben.
Figure imgf000099_0001
Schema 2. Die substituierten Pyrrolidinone der allgemeinen Formeln (I.3), (I.4) und (I.5) können auch über literaturbeschriebene Synthesewege hergestellt werden (vgl. WO2012098132). Durch Umsetzung einer geeigneten, gegebenenfalls weiter substituierten Itaconsäure (E) mit einem geeigneten, gegebenenfalls weiter substituierten Amin, bevorzugt einem Alkyl-, Cycloalkyl, Aryl- oder Heteroarylmethylamin, bei erhöhter Temperatur (z.B.150 °C) wird die entsprechende 5-Oxopyrrolidinyl-3-carbonsäure (F) erhalten (Schema 3). Die Ringschlussreaktion kann dabei in einer klassischen Syntheseapparatur mit Heizbad oder in einem geeigneten abgeschlossenen Gefäß unter Mikrowellenbedingungen durchgeführt werden. Die aus der Ringschlussreaktion hervorgehende intermediäre Carbonsäure (E) kann danach mit Hilfe geeigneter Kupplungsreagenzien [z.B.1-Ethyl-3-(3-dimethylaminopropyl)carbodiimid (EDC), 2,4,6- Tripropyl-1,3,5,2λ5,4λ5,6λ5-trioxatriphosphinan-2,4,6-trioxid (T3P), Hydroxybenzotriazol (HOBt)] unter Verwendung einer geeigneten Base (z.B. Triethylamin oder Diisopropylethylamin) zusammen mit dem entsprechenden gegebenenfalls weiter substituierten Amin in einem geeigneten polar-aprotischen Lösemittel (z.B. Dichlormethan) in die entsprechenden Amide (I.2) überführt werden. Weiterhin kann die Carbonsäure (E) über eine durch geeignete Reagenzien [z.B. Diphenylphosphorylazid (DPPA), Triethylamin und tert. Butanol] vermittelte und bei erhöhter Temperatur (z.B.80 °C) durchgeführte Abbaureaktion in das entsprechende geschützte Amin (F) umgesetzt werden. Durch Abspaltung der betreffenden Schutzgruppe [hier beispielhaft, aber nicht einschränkend eine tert-Butyloxycarbonyl (Boc)-Schutzgruppe] unter Verwendung eines geeigneten Reagens (z.B. beispielhaft, aber nicht einschränkend Salzsäure in Essigester zur Abspaltung der Boc-Gruppe) wird das entsprechende Amin (G) erhalten (gegebenenfalls auch als Salz, z.B. beispielhaft, aber nicht einschränkend als HCl-Salz). Das Amin (G) kann mit Hilfe geeigneter Kupplungspartner (beispielhaft, aber nicht einschränkend mit einem gegebenenfalls weiter substituierten Essigsäurechlorid, einem gegebenenfalls weitersubstituierten Isocyanat oder einem gegebenenfalls weiter substituierten Isothiocyanat) unter Verwendung einer geeigneten Base (z.B. Triethylamin oder Diisopropylethylamin) in einem geeigneten polar-aprotischen Lösemittel (z.B. Dichlormethan, Acetonitril) in die entsprechenden erfindungsgemäßen, gegebenenfalls weiter substituierten Acetamide (I.3), Harnstoffe (I.4) und Thioharnstoffe (I.5) überführt werden (vgl. WO2004026825, US20110189167, WO2009138438). Im nachfolgenden Schema 3 haben die Gruppen R1, R3, R5, R6, R11, R12, R20, R21, R22, R37 der allgemeinen Formeln (I.2), (I.3), (I.4) und (I.5) die weiter oben beschriebenen Definitionen, während R2, R4, R8, R9 und R10 beispielhaft, aber nicht einschränkend, für Wasserstoff stehen.
Figure imgf000100_0001
Schema 3. Alternativ kann das gegebenenfalls weiter substituierte Intermediat (G) auch ausgehend von einem weiter substituierten Glycinester (H) in einer mehrstufigen Reaktion über Acylierung, nachfolgende Cyclisierung mit Hilfe einer geeigneten Base (z.B. Natriumhydrid) in einem geeigneten polar- aprotischen Lösemittel (z.B. Tetrahydrofuran), Oximbildung mit Hilfe von Hydroxylamin-Hydrochlorid und einer geeigneten Base in einem geeigneten polar-aprotischen Lösemittel (z.B. Dichlormethan) sowie abschließende Reduktion des Oxims mit einem geeigneten Reduktionsmittel (z.B. Natriumcyanoborhydrid und Wasserstoff über Palladium auf Kohle) hergestellt werden (Schema 4). Im nachfolgenden Schema 4 haben die Gruppen R1, R3, R5, R11, R12, R37 die weiter oben beschriebenen Definitionen, während R2, R4, R6, R8, R9 und R10 beispielhaft, aber nicht einschränkend für Wasserstoff stehen. i
Figure imgf000101_0001
Schema 4. Alternativ können die gegebenenfalls weiter substituierten Harnstoffe der allgemeinen Formel (I.4) ausgehend von einer substituierten und mit geeigneten Schutzgruppen versehenen Aminosäure (J) hergestellt werden (vgl. WO2006063113). Dabei erfolgt zuerst die basenvermittelte Reaktion der Aminosäure (J) mit einem geeigneten Isocyanat zu einem gegebenenfalls weiter substituierten Intermediat (K). Die so erhaltene intermediäre, gegebenenfalls weiter substituierte Carbonsäure (K) kann danach mit Hilfe geeigneter Kupplungsreagenzien [z.B.1-Ethyl-3-(3- dimethylaminopropyl)carbodiimid (EDC), 2,4,6-Tripropyl-1,3,5,2λ5,4λ5,6λ5-trioxatriphosphinan-2,4,6- trioxid (T3P), Hydroxybenzotriazol (HOBt)] unter Verwendung einer geeigneten Base (z.B. Triethylamin oder Diisopropylethylamin) zusammen mit dem entsprechenden Amin R1-NH2 in einem geeigneten polar-aprotischen Lösemittel (z.B. Dichlormethan) in das entsprechende, gegebenenfalls weiter substituierte Intermediat (L) überführt werden, das nach Abspaltung der Schutzgruppe der weiteren Säurefunktion (beispielhaft, aber nicht einschränkend mit Wasserstoff über Palladium auf Kohle in einem geeigneten polar-protischen Lösemittel wie Methanol zur Abspaltung einer Benzylschutzgruppe) mit Hilfe einer geeigneten Base cyclisiert wird. Durch die abschließende Cyclisierung erhält man erfindungsgemäße, gegebenenfalls weiter substituierte Verbindungen der allgemeinen Formel (I.4) (Schema 5). Im nachfolgenden Syntheseschema 4 haben die Gruppen R1, R5, R37 die weiter oben beschriebenen Definitionen, während R2, R3, R4, R6, R8 und R9 beispielhaft, aber nicht einschränkend für Wasserstoff stehen.
Figure imgf000102_0001
Schema 5. Die Verbindungen vom Typ I.2 konnten auch in Analogie zu den Vorschriften aus der Patentanmeldung WO2011/35332 (Schema 6) hergestellt werden. Hierbei werden, wie im Schema 6 dargestellt, durch Kondensation der entsprechenden Aniline mit Itaconsäurederivaten (M) die korrespondierenden Pyrrolidoncarbonsäuren (O) hergestellt. Nach Veresterung der Säuren (O) z.B. unter mithilfe von Orthoester oder durch andere Methoden, erhält man die entsprechenden Carbonsäureester (P). Diese werden nach Deprotonierung mit einer starken Base wie z.B. Natriumhydrid oder Lithiumhexamethyldisilazid oder Lithiumdiisopropylamid oder mit einer geeigneten anderen anorganischen oder organischen Base in einem inerten Lösungsmittel wie THF, Diethylether oder Dimethylformamid oder einem anderen geeigneten Lösungsmittel bei Temperaturen zwischen -78 °C und 180 °C mit einem Alkylierungsmittel wie einem Alkylhalogenid wie Methyliodid oder Dimethylsulfat zu den alkylierten Pyrrolidoncarbonsäureestern (Q) umgesetzt. Nach Verseifung zu den korrespondierenden Säuren mit anorganischen Basen wir Natriumhydroxid oder Lithiumhydroxid in einem geeigneten Lösungsmittel wir Wasser, Ethanol oder THF erhält man die freie Carbonsäure oder deren Salz (R), die dann unter Standardbedingungen mit einem Kupplungsreagenz wir T3P, Carbonyldiimidazol, HATU und anderen geeignete Methoden zu den Amiden (I.2) umgesetzt werden. H
Figure imgf000103_0002
Schema 6. In Schema 7 wird die Synthese von einigen nicht-kommerziellen Aminen aufgeführt. Ausgehend vom Pyrimidon (S) lassen sich durch Oximierung, nachfolgende Chlorierung, Reduktion, Einführung der Boc-Schutzgruppe und nucleophile Substitution mit einer Vielzahl an O-, S- und N-Nucleophilen in die entsprechenden Pyrimidinmethylamine (T) umwandeln.
Figure imgf000103_0001
Nu- = Cl, O-, S- und N-Nucleophile Schema 7. Ausgewählte detaillierte Synthesebeispiele für die erfindungsgemäßen Verbindungen der allgemeinen Formeln (I) sind im Folgenden aufgeführt. Die angegebenen Beispielnummern entsprechen den in den nachstehenden Tabellen I.1 bis I.5 genannten Nummerierungen. Die 1H-NMR-, 13C-NMR- und 19F- NMR-spektroskopischen Daten, die für die in den nachfolgenden Abschnitten beschriebenen chemischen Beispiele angegeben sind, (400 MHz bei 1H-NMR und 150 MHz bei 13C-NMR und 375 MHz bei 19F-NMR, Lösungsmittel CDCl3, CD3OD oder d6-DMSO, interner Standard: Tetramethylsilan δ = 0.00 ppm), wurden mit einem Gerät der Firma Bruker erhalten, und die bezeichneten Signale haben die nachfolgend aufgeführten Bedeutungen: br = breit(es); s = Singulett, d = Dublett, t = Triplett, dd = Doppeldublett, ddd = Dublett eines Doppeldubletts, m = Multiplett, q = Quartett, quint = Quintett, sext = Sextett, sept = Septett, dq = Doppelquartett, dt = Doppeltriplett. Bei Diastereomerengemischen werden entweder die jeweils signifikanten Signale beider Diastereomere oder das charakteristische Signal des Hauptdiastereomers angegeben. Die verwendeten Abkürzungen für chemische Gruppen haben beispielsweise die nachfolgenden Bedeutungen: Me = CH3, Et = CH2CH3, t-Hex = C(CH3)2CH(CH3)2, t- Bu = C(CH3)3, n-Bu = unverzweigtes Butyl, n-Pr = unverzweigtes Propyl, i-Pr = verzweigtes Propyl, c- Pr = Cyclopropyl, c-Hex = Cyclohexyl. Ausgewählte Synthesebeispiele: I.1-001: 2-[1-[(3-Chlor-2-fluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essigsäure
Figure imgf000104_0001
3-Chlor-2-fluorbenzylamin (221 mg, 1.39 mmol, 1.0 eq.) und Trans-3-Hexendisäure (200 mg, 1.39 mmol, 1.0 eq.) wurden in Wasser suspendiert (5.0 mL) und in ein Mikrowellengefäß überführt, das danach fest verschlossen wurde. Das Reaktionsgemisch wurde 1 h lang unter Mikrowellenbedingungen auf 190 °C erhitzt. Der Innendruck stieg dabei auf ca.18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch eingeengt und über eine präparative HPLC gereinigt. Auf diese Weise wurde racemische 2-[1-[(3-Chlor-2-fluorphenyl)methyl]-5-oxo- pyrrolidin-2-yl]essigsäure I.1-001 (135 mg, 34% der Theorie) in Form eines farblosen Öls erhalten.1H-NMR (400.0 MHz, CDCl3) δ ppm 7.36-7.32 (m, 1H), 7.22-7.18 (m, 1H), 7.09-7.04 (m, 1H), 4.91-4.87 (d, 1H), 4.27-4.23 (d, 1H), 3.94-3.88 (m, 1H), 2.78-2.73 (dd, 1H), 2.62-2.42 (m, 3H), 2.37-2.26 (m, 1H), 1.93-1.85 (m, 1H). Nr. I.1-604 und Nr. I.1-605: (+)- und (-)-2-[1-[(3-Chlor-2-fluorphenyl)methyl]-5-oxo-pyrrolidin-2- yl]essigsäure:
Figure imgf000105_0001
Die oben aufgeführte Reaktion wurde unter Verwendung der gleichen Menge an Reagenzien wiederholt und eine vereinigte Menge an 2-[1-[(3-Chlor-2-fluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essigsäure (I.1-001, 200 mg) wurde über präparative chirale SFC-Trennung unter Verwendung einer chiralen Opti Prep ODB Säule (Gradient Chir_C3_IE_B1_90_CO2_MeOH_6min_CD) in die Enantiomere Ent-1 I.1- 604 (85 mg, Retentionszeit 1.177, Drehwert 28.50° - 20mg/10 mL), 1H-NMR (400.0 MHz, CDCl3) δ ppm 7.38-7.33 (m, 1H), 7.22-7.17 (m, 1H), 7.09-7.03 (m, 1H), 4.92-4.88 (d, 1H), 4.27-4.23 (d, 1H), 3.94-3.88 (m, 1H), 2.78-2.73 (dd, 1H), 2.62-2.42 (m, 3H), 2.39-2.25 (m, 1H), 1.93-1.85 (m, 1H) und Ent-2 I.1-605 (91 mg, Retentionszeit 1.862, Drehwert -36.00° - 22 mg/100 mL) getrennt, 1H-NMR (400.0 MHz, CDCl3) δ ppm 7.36-7.31 (m, 1H), 7.23-7.15 (m, 1H), 7.09-7.04 (m, 1H), 4.91-4.85 (d, 1H), 4.27-4.23 (d, 1H), 3.93-3.87 (m, 1H), 2.77-2.72 (dd, 1H), 2.64-2.43 (m, 3H), 2.37-2.26 (m, 1H), 1.93- 1.84 (m, 1H). I.1-003 - 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essigsäure:
Figure imgf000105_0002
2,3-Difluorbenzylamin (993 mg, 6.93 mmol, 1.0 eq.) und Trans-3-Hexendisäure (1.00 g, 6.93 mmol, 1.0 eq.) wurden in Wasser suspendiert (10.0 mL) und in ein Mikrowellengefäß überführt, das danach verschlossen wurde. Das Reaktionsgemisch wurde 1 h lang unter Mikrowellenbedingungen auf 190 °C erhitzt. Der Innendruck stieg dabei auf ca.18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch eingeengt und über eine preparative HPLC gereinigt. Auf diese Weise wurde 2- [1-[(2,3-difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essigsäure (182.0 mg, 23% der Theorie) in Form eines farblosen Öls erhalten.1H-NMR (600.0 MHz, d6-DMSO): δ= 1.69 - 1.76 (m, 1 H), 2.14 - 2.29 (m, 2 H), 2.34 - 2.45 (m, 2 H), 2.69 (dd, J=15.97, 4.05 Hz, 1 H), 3.76 (tt, J=8.31, 4.14 Hz, 1 H), 4.24 (d, J=15.85 Hz, 1 H), 4.73 (d, J=15.85 Hz, 1 H), 7.08 (t, J=7.03 Hz, 1 H), 7.16 - 7.21 (m, 1 H), 7.36 (q, J=8.42 Hz, 1 H). I.1-036: 2-(4-Methylphenoxy)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]acetat
Figure imgf000106_0001
Zu einer Lösung von 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure (150.0 mg, 0.55 mmol, 1.0 eq.) in Dichlormethan (20 mL) wurden 2-(4-Methylphenoxy)ethanol (170.0 mg, 1.11 mmol, 2.0 eq.), DMAP (0.7 mg, 0.05 mmol, 0.1 eq.) und 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimid (117.0 mg, 0.61 mmol, 1.1 eq.) zugegeben. Die Reaktionsmischung wurde 5 h lang bei Raumtemperatur gerührt. Danach erfolgte die Zugabe von Wasser (20 mL), und die wässrige Phase wurde gründlich mit Dichlormethan (3 x 50 mL) extrahiert. Die vereinigten organischen Phasen wurden über Magnesiumsulfat getrocknet, filtriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbleibenden Rückstands [Silica gel; Heptan/EtOAc (4:1)] wurde 2-(4-Methylphenoxy)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]acetat I.1-036 (141.0 mg, 62% der Theorie) in Form eines farblosen Öls erhalten.1H-NMR(400.1 MHz, CDCl3): δ ppm 1.79 - 1.89 (m, 1 H), 2.22 - 2.31 (m, 4 H), 2.34 - 2.52 (m, 3 H), 2.75 (dd, J=15.57, 3.99 Hz, 1 H), 3.88 (dt, J=8.31, 4.16 Hz, 1 H), 4.09 - 4.15 (m, 2 H), 4.24 (d, J=15.49 Hz, 1 H), 4.37 - 4.44 (m, 2 H), 4.86 (dd, J=15.57, 1.55 Hz, 1 H), 6.75 - 6.82 (m, 2 H), 7.00 - 7.12 (m, 5 H). I.1-056: 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(4-methyl-1,2,5-oxadiazol-3- yl)acetamid
Figure imgf000106_0002
Zu einer Lösung von 4-Methyl-1,2,5-oxadiazol-3-amin (74.0 mg, 0.74 mmol, 1.0 eq.) in Dichlormethan (6 mL) wurden 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure (200.0 mg, 0.74 mmol, 1.0 eq.) und 2,4,6-Tripropyl-1,3,5,2λ5,4λ5,6λ5-trioxatriphosphinan-2,4,6-trioxid (709.0 mg, 0.663 mL, 1.11 mmol, 1.5 eq., 50%-ige Lösung in EtOAc) gegeben. Das Reaktionsgemisch wurde 1 h lang bei Raumtemperatur gerührt. Danach erfolgten die tropfenweise Zugabe von Triethylamin (376.0 mg, 0.52 mL, 3.71 mmol, 5.0 eq.) sowie die Zugabe von DMAP (18.0 mg, 0.14 mmol.0.2 eq.), und das resultierende Reaktionsgemisch wurde 16 h bei Raumtemperatur gerührt. Danach erfolgte die Zugabe von Wasser (20 mL), und die wässrige Phase wurde gründlich mit Dichlormethan (3 x 50 mL) extrahiert. Die vereinigten organischen Phasen wurden über Magnesiumsulfat getrocknet, filtriert und unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung des verbleibenden Rückstands wurde 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(4-methyl-1,2,5- oxadiazol-3-yl)acetamid I.1-056 (114.0 mg, 43% der Theorie) in Form eines gelblichen Öls erhalten. 1H-NMR(400.1 MHz, d6-DMSO): δ ppm 1.77 - 1.87 (m, 1 H), 2.18 - 2.37 (m, 5 H), 2.37 - 2.44 (m, 1 H), 2.54 - 2.62 (m, 1 H), 2.88 (dd, J=14.92, 4.16 Hz, 1 H), 3.90 (br d, J=3.91 Hz, 1 H), 4.28 (d, J=15.98 Hz, 1 H), 4.73 (d, J=16.14 Hz, 1 H), 7.05 - 7.11 (m, 1 H), 7.15 - 7.22 (m, 1 H), 7.30 - 7.39 (m, 1 H). I.1-133: 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essigsäure
Figure imgf000107_0001
2,3-Dichlorbenzylamin (1.21 g, 6.93 mmol, 1.0 eq.) und Trans-3-Hexendisäure (1.00 g, 6.93 mmol, 1.0 eq.) wurden in Wasser suspendiert (10.0 mL) und in ein Mikrowellengefäß überführt, das danach verschlossen wurde. Das Reaktionsgemisch wurde 1 h lang unter Mikrowellenbedingungen auf 190 °C erhitzt. Der Innendruck stieg dabei auf ca.18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch eingeengt und über eine preparative HPLC gereinigt. Auf diese Weise wurde 2- [1-[(2,3-dichlorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essigsäure I.1-133 (847.0 mg, 40% der Theorie) in Form eines farblosen Feststoffs.1H-NMR (400.1 MHz, d6-DMSO): δ ppm 1.72 - 1.82 (m, 1 H), 2.19 - 2.34 (m, 2 H), 2.36 - 2.45 (m, 2 H), 2.65 (dd, J=16.06, 4.32 Hz, 1 H), 3.81 (tt, J=8.09, 4.22 Hz, 2 H), 4.29 (d, J=16.47 Hz, 1 H), 4.68 (d, J=16.47 Hz, 1 H), 7.22 (dd, J=7.66, 1.47 Hz, 1 H), 7.35 (t, J=7.91 Hz, 1 H), 7.57 (dd, J=7.99, 1.47 Hz, 1 H). I.1-311: 2-[1-[(2,3-Dichlorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamid
Figure imgf000107_0002
Zu einer Lösung von 2-[1-[(2,3-Dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure (250.0 mg, 0.82 mmol, 1.0 eq.) in abs. Dichlormethan (30 mL) wurden N,N-Dimethylsulfamid (205.0 mg, 1.65 mmol, 2.0 eq.), DMAP (0.1 mg, 0.08 mmol, 0.1 eq.) und 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimid (174.0 mg, 0.91 mmol, 1.1 eq.) gegeben. Das resultierende Reaktionsgemisch wurde 16 h bei Raumtemperatur gerührt. Danach erfolgte die Zugabe von Wasser (20 mL), und die wässrige Phase wurde gründlich mit Dichlormethan (3 x 50 mL) extrahiert. Die vereinigten organischen Phasen wurden über Magnesiumsulfat getrocknet, filtriert und unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung des verbleibenden Rückstands wurde 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxo- pyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamid I.1-311 (151.0 mg, 44% der Theorie) als farbloser Feststoff erhalten.1H-NMR (400 MHz, d6-DMSO) δ ppm 1.75 - 1.83 (m, 1 H), 2.18 - 2.46 (m, 4 H), 2.66 - 2.73 (m, 1 H), 3.85 (tt, J=8.15, 4.08 Hz, 1 H), 4.27 (d, J=16.63 Hz, 1 H), 4.66 (d, J=16.63 Hz, 1 H), 7.17 - 7.21 (m, 1 H), 7.36 (t, J=15.81 Hz, 1 H), 7.56 - 7.60 (m, 1 H). I.1-599: [5-Oxo-1-(2,3,6-trifluorbenzyl)pyrrolidin-2-yl]essigsäure.
Figure imgf000108_0001
Trans-3-Hexendisäure (300 mg, 2.08 mmol) und 1-(2,3,6-Trifluorphenyl)methylamin (335 mg, 2.08 mmol) wurden zusammen mit Wasser (5 ml) in ein Mikrowellengefäß gegeben und 1 h lang bei bei einer Temperatur von 190 °C umgesetzt. Dabei stieg der Druck bis auf 18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung wurde [5-Oxo-1-(2,3,6-trifluorbenzyl)pyrrolidin-2-yl]essigsäure in Form eines farblosen Feststoffs (144 mg, 25% der Theorie) erhalten, 1H-NMR (400 MHz, CDCl3) δ ppm 7.18- 7.10 (m, 1H), 6.90-6.84 (m, 1H), 5.19 (d, 1H), 4.17 (d, 1H), 3.86-3.80 (m, 1H), 2.84-2.79 (dd, 1H), 2.62- 2.43 (m, 3H), 2.33-2.25 (m, 1H), 1.93-1.86 (m, 1H). I.1-600: [5-Oxo-1-(2,3,4-trifluorbenzyl)pyrrolidin-2-yl]essigsäure.
Figure imgf000108_0002
Trans-3-Hexendisäure (100 mg, 0.69 mmol) und 1-(2,3,4-Trifluorphenyl)methylamin (112 mg, 0.69 mmol) wurden zusammen mit Wasser (5 ml) in ein Mikrowellengefäß gegeben und 1 h lang bei bei einer Temperatur von 190 °C umgesetzt. Dabei stieg der Druck bis auf 18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung wurde [5-Oxo-1-(2,3,4-trifluorbenzyl)pyrrolidin-2-yl]essigsäure in Form eines farblosen Feststoffs (52 mg, 27% der Theorie) erhalten, 1H-NMR (400 MHz, CDCl3) δ ppm 7.09- 7.03 (m, 1H), 6.98-6.92 (m, 1H), 4.87 (d, 1H), 4.21 (d, 1H), 3.93-3.87 (m, 1H), 2.80-2.75 (dd, 1H), 2.61- 2.40 (m, 3H), 2.38-2.27 (m, 1H), 1.94-1.86 (m, 1H). I.1-601: [5-Oxo-1-(2,3,5-trifluorbenzyl)pyrrolidin-2-yl]essigsäure.
Figure imgf000109_0002
Trans-3-Hexendisäure (200 mg, 1.39 mmol) und 1-(2,3,5-Trifluorphenyl)methylamin (224 mg, 1.39 mmol) wurden zusammen mit Wasser (5 ml) in ein Mikrowellengefäß gegeben und 1 h lang bei bei einer Temperatur von 190 °C umgesetzt. Dabei stieg der Druck bis auf 18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung wurde [5-Oxo-1-(2,3,5-trifluorbenzyl)pyrrolidin-2-yl]essigsäure in Form eines farblosen Feststoffs (116 mg, 32% der Theorie) erhalten, 1H-NMR (400 MHz, CDCl3) δ ppm 6.90- 6.79 (m, 2H), 4.85 (d, 1H), 4.29 (d, 1H), 3.95-3.88 (m, 1H), 2.78-2.74 (dd, 1H), 2.61-2.42 (m, 3H), 2.39- 2.30 (m, 1H), 1.94-1.86 (m, 1H). I.1-602: [5-Oxo-1-(2,3-dimethylbenzyl)pyrrolidin-2-yl]essigsäure.
Figure imgf000109_0003
Trans-3-Hexendisäure (300 mg, 2.08 mmol) und 1-(2,3-Dimethylphenyl)methylamin (281 mg, 2.08 mmol) wurden zusammen mit Wasser (5 ml) in ein Mikrowellengefäß gegeben und 1 h lang bei bei einer Temperatur von 190 °C umgesetzt. Dabei stieg der Druck bis auf 18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung wurde [5-Oxo-1-(2,3-dimethylbenzyl)pyrrolidin-2-yl]essigsäure in Form eines farblosen Feststoffs (131 mg, 24% der Theorie) erhalten, 1H-NMR (400 MHz, CDCl3) δ ppm 7.13- 7.11 (d, 1H), 7.09-7.05 (dd, 1H), 6.98-6.96 (d, 1H), 5.04 (d, 1H), 4.08 (d, 1H), 3.80-3.75 (m, 1H), 2.68- 2.50 (m, 3H), 2.48-2.41 (dd, 1H), 2.31-2.23 (m, 1H), 2.28 (s, 3H), 2.15 (s, 3H), 1.95-1.88 (m, 1H). I.1-603: 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(1,2,4-thiadiazol-5-yl)acetamid
Figure imgf000109_0001
Zu einer Lösung von 5-Amino-1,2,4-thiazolylhydrochlorid (120 mg, 0.87 mmol, 1.0 eq.) in Dichlormethan (5 mL) wurden 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essigsäure (235 mg, 0.87 mmol, 1.0 eq.) und cyclisches 1-Propylphosphonsäureanhydrid (T3P®, 722 mg, 0.68 mL, 1.13 mmol, 1.3 eq., 50%-Lösung in Tetrahydrofuran) gegeben. Das Reaktionsgemisch wurde 1 h land bei Raumtemperatur gerührt und danach mit Tiethylamin (0.37 mL, 2.62 mmol, 3.0 eq.) tropfenweise versetzt. Das resultierende Reaktionsgemisch wurde weitere 8 h lang bei Raumtemperatur und danach mit Wasser (20 mL) versetzt und mehrfach gründlich mit Dichlormethan extrahiert (3 x 50 mL). Die vereinigten organischen Phasen wurden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeengt. Durch Reinigung des resultierenden Rohproduktes mit Hilfe einer präparativen HPLC-Trennung wurde 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(1,2,4- thiadiazol-5-yl)acetamid I.1-603 (110 mg, 35% der Theorie) in Form eines farblosen Feststoffs erhalten. 1H-NMR (400.0 MHz, CDCl3) δ ppm 11.77 (br. s, 1H, NH), 8.21 (s, 1H), 7.08-7.01 (m, 3H), 4.84-4.80 (d, 1H), 4.36-4.32 (d, 1H), 4.16-4.12 (m, 1H), 3.04-2.99 (dd, 1H), 2.72-2.66 (dd, 1H), 2.62-2.48 (m, 2H), 2.44-2.37 (m, 1H), 1.95-1.88 (m, 1H). I.2-32: N-[(2-Chlorpyridin-4-yl)methyl]-6-(3,5-dichlorphenyl)-2,4-dimethyl-7-oxo-6-azabicyclo [3.2.1]oct-3-en-8-carboxamid
Figure imgf000110_0001
Unter Stickstoff wurden 91.0 mg (0.27 mmol) 6-(3,5-Dichlorphenyl)-2,4-dimethyl-7-oxo-6- azabicyclo[3.2.1]oct-3-en-8-carbonsäure in 2 mL trockenem Dichlormethan vorgelegt, dann nacheinander mit 36.1 mg (0.27 mmol) HOBT in 1 ml Dichlormethan, 52.7 mg (0.29 mmol) 1-(2- Chlorpyridin-4-yl)methanaminhydrochlorid, 103.7 mg (0.8 mmol) Ethyldiisopropylamin und zuletzt mit 66.7 mg (0.35 mmol) EDCl versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung eingedampft und über Kieselgel gereinigt. Nach Reinigung über Kieselgel wurden 120 mg (Reinheit 95%, 92% der Theorie) des Produktes N-[(2-Chlorpyridin-4-yl)methyl]-6-(3,5-dichlorphenyl)- 2,4-dimethyl-7-oxo-6-azabicyclo[3.2.1]oct-3-en-8-carboxamid erhalten.1H-NMR (400.0 MHz, CDCl3) δ 8.2776 (2.8); 8.2761 (2.7); 8.2648 (2.9); 8.2634 (2.8); 7.5270 (11.8); 7.5225 (11.8); 7.5190 (1.6); 7.2715 (1.1); 7.2707 (1.2); 7.2601 (201.1); 7.2100 (1.0); 7.1440 (3.4); 7.1395 (8.3); 7.1349 (5.1); 7.0283 (1.9); 7.0264 (1.6 ); 7.0246 (1.8); 7.0155 (1.8); 7.0137 (1.5); 7.0118 (1.6); 6.9961 (1.1); 6.2238 (0.8); 5.3596 (1.8); 5.3563 (1.8); 4.5527 (2.7); 4.4646 (1.9); 4.4477 (2.8); 4.4310 (1.9); 3.0052 (4.5); 2.9545 (1.4); 2.9424 (1.6); 2.7799 (0.6); 2.7741 (0.7); 2.7679 (0.8); 2.7618 (0.8); 2.7558 (0.7); 2.7497 (0.6); 2.0905 (1.2); 1.8615 (6.3); 1.8572 (7.7); 1.8555 (7.6); 1.8513 (6.2); 1.5970 (0.6); 1.5807 (0.7); 1.5473 (16.0); 1.5242 (0.9); 1.5072 (0.7); 1.2554 (0.7); 1.2076 (9.5); 1.1894 (9.3); 0.0079 (2.4); -0.0002 (85.7); -0.0085 (2.6). I.2-33: 1-[3,5-Bis(trifluormethyl)phenyl]-N-{[2-(ethylamino)pyrimidin-4-yl]methyl}-5-oxopyrrolidin-3- carboxamid
Figure imgf000111_0001
Hierzu wurden 202.0 mg (0.29 mmol) Ethan-1,2-diylbis{1-[3,5-bis(trifluormethyl)phenyl]-5- oxopyrrolidin-3-carboxylat} in 6 mL THF und 2 mL Wasser gelöst und zunächst im Eisbad mit 0.3 mL 2M Natronlauge (=24 mg NaOH (0.6 mmol)) gerührt. Man lässt auf Raumtemperatur aufwärmen und kühlt nach 1 h auf 0 °C ab. Die Lösung wurde mit 2M Salzsäure neutralisiert. Anschließend wurde die Reaktionsmischung eingedampft, mit Wasser aufgenommen und mit 2M Salzsäure auf pH 2 gebracht. Der Feststoff wurde abgesaugt und im Vakuum getrocknet. Man erhielt 183.0 mg (Reinheit 95 %, 90% der Theorie) der gewünschten 1-[3,5-Bis(trifluormethyl)phenyl]-5-oxopyrrolidin-3-carbonsäure. 1H-NMR (400.0 MHz, d1-Chlorform): δ= 2.95 - 3.09 (m, 2 H) 3.44 - 3.54 (m, 1 H) 4.12 - 4.26 (m, 2 H) 7.68 (bs, 1 H) 8.12 (bs, 2 H).10.0 g (72.0 mmol) 2-Chlorpyrimidin-4-carbonitril in Methanol (50 mL) wurden vorsichtig bei 0 °C mit 30 mL 30% Ethylamin in Methanol (ca.200 mmol) versetzt und 2 h bei dieser Temperatur gerührt. Danach wurde die Reaktionsmischung in Wasser gegeben (50 mL). Der gebildete, gelbe Feststoff 2-(Ethylamino)pyrimidin-4-carbonitril wurde ohne weitere Reinigung abfiltriert und getrocknet. Dieses Rohprodukt wurde mit 2.8 g Pd/C (10 wt%) und 14.6 g (144.3 mmol, 20 mL) Triethylamin in Ethanol (200 mL) versetzt und bei Normaldruck und Raumtemperatur über Nacht hydriert (Luftballon). Anschließend wurde die Reaktionsmischung filtriert und das Filtrat eingeengt. Der Rückstand wurde in EtOAc (100 mL) gelöst und mit 15.0 mL 4M (60 mmol) Salzsäure in Dioxan gerührt. Der gebildete Feststoff wurde abfiltriert und getrocknet. Man erhielt 6.5 g (48% der Theorie) 4-(Aminomethyl)-N-ethylpyrimidin-2-amin Hydrochlorid als braunen Feststoff. MS-ESI: [M+H]+ 152.1H-NMR (500.0 MHz, d6-DMSO): δ= 10.08 (s, 1H), 8.71 (s, 3H), 8.40 (d, J = 4.5 Hz, 1H), 6.92 (d, J = 5.5 Hz, 1H), 4.16 (s, 2H), 3.50 (s, 2H), 1.18-1.14(m, 3H). Unter Stickstoff wurden 61.0 mg (0.17 mmol) 1-[3,5-Bis(trifluormethyl)phenyl]-5-oxopyrrolidin-3-carbonsäure in 3 mL trockenem THF vorgelegt, dann nacheinander mit 24.2 mg (0.17 mmol) HOBT in 1 mL THF, 37.1 mg (0.19mmol) 4- (Aminomethyl)-N-ethylpyrimidin-2-amin Hydrochlorid, 92.4 mg (0.71 mmol) Ethyldiisopropylamin und zuletzt mit 44.6 mg (0.23 mmol) EDCl in 6 mL THF versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung einrotiert, mit 2 mL Dichlormethan aufgenommen und direkt über Kieselgel gereinigt. Man erhielt 79.0 mg (Reinheit 90%, 84 % der Theorie) des Produktes N1-[3,5- Bis(trifluormethyl)phenyl]-N-{[2-(ethylamino)pyrimidin-4-yl]methyl}-5-oxopyrrolidin-3-carboxamid in Form eines farblosen Feststoffs.1H-NMR(400.0 MHz, CDCl3): δ 8.2489 (1.7); 8.2364 (1.7); 8.1401 (6.4); 7.9001 (0.5); 7.8791 (0.6); 7.6685 (0.6); 7.6510 (2.9); 7.2621 (49.4); 7.0400 (0.9); 6.4962 (3.4); 6.4835 (3.4); 4.4364 (3.1); 4.4337 (3.2); 4.4246 (3.2); 4.4219 (3.2); 4.2766 (1.7); 4.2588 (1.8); 4.2528 (2.2); 4.2349 (2.2); 4.0945 (2.0); 4.0730 (2.6); 4.0708 (2.2); 4.0492 (1.7); 3.4862 (1.3); 3.4784 (1.4); 3.4687 (1.4); 3.4613 (1.3); 3.3801 (1.0); 3.3622 (1.0); 3.3594 (1.2); 3.3567 (1.1); 3.3388 (1.0); 3.0772 (1.6); 3.0562 (1.3); 3.0341 (3.0); 3.0131 (2.8); 2.9627 (3.0); 2.9391 (2.8); 2.9196 (1.5); 2.8960 (1.3); 2.0944 (0.8); 1.3310 (0.8); 1.2873 (7.6); 1.2832 (1.8); 1.2693 (16.0); 1.2573 (1.9); 1.2512 (7.7); 1.2395 (1.4); 1.2215 (0.6); 0.0079 (0.6); -0.0002 (17.8); -0.0085 (0.7). I.2-113: N-{[2-(Cyclobutyloxy)pyridin-4-yl]methyl}-1-(3,5-difluorphenyl)-3-methyl-5-oxopyrrolidin-3- carboxamid
Figure imgf000112_0001
Eine Mischung aus 29.8 g (0.230 mol) 3,5-Difluoranilin and 30.0 g (0.230 mol) Itaconsäure wurden zusammen bei 130 °C für 1 h erhitzt. Nach Beendigung der Reaktion wurde bei ca.70 °C mit MTBE (70 mL) versetzt und auf Raumtemperatur abgekühlt. Anschließend wurde mit 400 mL Hexan versetzt und weitere 12 h gerührt, der Feststoff abfiltriert, mit Hexan gewaschen und im Vakuum bei 40 °C getrocknet. Man erhielt 49.0 g (88 % der Theorie) der 1-(3,5-Difluorphenyl)-5-oxopyrrolidin-3- carbonsäure als braunen Feststoff.49.0 g (0.203 mol) der oben erhaltenen 1-(3,5-Difluorphenyl)-5- oxopyrrolidin-3-carbonsäure wurden in 220 mL Methanol gelöst und auf 0 °C abgekühlt. Anschließend wurde bei dieser Temperatur mit 792 mg (0.72 mL=10.0 mmol) Acetylchlorid und 21.5 g (22.0 mL = 0.203 mol) Trimethylorthoformat behandelt und danach für 1 h auf 64 °C erhitzt. Danach wurde die Reaktionsmischung im Vakuum eingedampft und der Rückstand in 750 mL Dichlormethan gelöst. Nach Waschen mit 500 mL gesättigter wässriger Natriumhydrogencarbonatlösung und 300 mL Kochsalzlösung und Trocknen über Natriumsulfat erhielt man ein Rohprodukt, welches über Kieselgel chromatographisch gereinigt wurde. Man erhielt 33.5 g (65 % der Theorie) an Methyl-1-(3,5- difluorphenyl)-5-oxopyrrolidin-3-carboxylat als weißen Feststoff. Unter Argon wurden 38.0 g (0.149 mol) des oben erhaltenen Methyl-1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-carboxylats in 300 mL trockenem DMF gelöst und bei 0 °C mit 10.7 g (0.268 mol) 60%iges Natriumhydrid und dann mit 24.71 g (0.174 mol) Methyliodid versetzt. Anschließend wurde 1 h bei 0 °C weitergerührt und auf Raumtemperatur erwärmt. Nach 16 h wurde mit 500 mL gesättigter Ammoniumchloridlösung hydrolysiert und zweimal mit je 500 mL MTBE extrahiert. Die vereinten organischen Phasen wurden über Natriumsulfat getrocknet, filtriert und im Vakuum eingeengt. Der Rückstand wurde in Dichlormethan gelöst und über Silicagel chromatographiert. Man erhielt 6.0 g (15 % der Theorie) an Methyl-1-(3,5-difluorphenyl)-3-methyl-5-oxopyrrolidin-3-carboxylat als farblosen Feststoff. Eine Suspension aus 6.30 g (0.023 mol) oben erhaltenem Methyl-1-(3,5-difluorphenyl)-3-methyl-5- oxopyrrolidin-3-carboxylat in 50 mL Methanol und 50 mL Wasser wurde mit 9.8 g (0.230 mol) Lithiumhydroxid bei Raumtemperatur versetzt und zunächst bei Raumtemperatur und dann 1 h bei 80 °C erhitzt. Nach beendeter Reaktion wurde abgekühlt und das Solvens im Vakuum abgedampft. Der Rückstand wurde mit 100 mL Wasser aufgenommen und zweimal mit je 150 mL MTBE gewaschen. Danach wurde der pH der verbleibenden wässrigen Phase mit 2N Salzsäure auf 3-4 eingestellt und die wässrige Phase zweimal mit je 500 mL Ethylacetat extrahiert. Nach Trocknen der vereinten Essigesterphasen wurde filtriert und das Solvens im Vakuum entfernt. Der feste Rückstand wurde in 100 mL Hexan suspendiert (5 h), abfiltiert, mit Hexan gewaschen und im Vakuum getrocknet. Man erhielt 5.20 g (Reinheit 98 %, 87 % der Theorie) der gewünschten 1-(3,5-Difluorphenyl)-3-methyl-5- oxopyrrolidin-3-carbonsäure als farblosen Feststoff.1H-NMR (400.0 MHz, d1-Chlorform): δ = 1.57 (s, 3H), 2.59 (d, J = 17.3 Hz, 1H) 3.19 (br d, J = 17.3 Hz, 1H), 3.62 (d, J = 9.9 Hz, 1H), 4.36 (d, J = 10.0 Hz, 1H), 6.58 – 6.68 (m, 1H), 7.18 – 7.25 (m, 2H). Unter Stickstoff wurden 80 mg (0.31 mmol) 1-(3,5- Difluorphenyl)-3-methyl-5-oxopyrrolidin-3-carbonsäure in 4 mL trockenem THF vorgelegt, dann nacheinander mit 42.4 mg (0.31 mmol) HOBT in 1 ml THF, 61.5 mg (0.34 mmol) 1-[2- (Cyclobutyloxy)pyridin-4-yl]methanamin, 121.5 mg (0.94 mmol) Ethyldiisopropylamin und zuletzt mit 78.1 mg (0.40 mmol) EDCl in 5 mL THF versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung eingedampft, das Rohprodukt in 2.5 mL Dichlormethan aufgenommen und direkt über Kieselgel gereinigt. Nach Reinigung über Kieselgel wurden 126.0 mg (Reinheit 98 %, 95 % der Theorie) an N-{[2-(Cyclobutyloxy)pyridin-4-yl]methyl}-1-(3,5-difluorphenyl)-3-methyl-5-oxo- pyrrolidin-3-carboxamid als halbfestes Produkt erhalten.1H-NMR(400.0 MHz, CDCl3): δ 8.0973 (12.5); 8.0960 (12.3); 8.0842 (12.7); 8.0828 (12.6); 7.5183 (4.9); 7.3089 (1.2); 7.2928 (1.5); 7.2740 (4.6); 7.2595 (874.7); 7.2537 (9.4); 7.2529 (8.3); 7.2505 (3.4); 7.2488 (2.2); 7.2481 (2.3); 7.2433 (5.3); 7.2393 (13.8); 7.2336 (11.8); 7.2281 (2.2); 7.2219 (1.8); 7.2147 (1.0); 7.2092 (1.9); 6.9955 (4.7); 6.7332 (7.8); 6.7295 (8.2); 6.7200 (7.7); 6.7164 (7.9); 6.6424 (3.0); 6.6367 (5.4); 6.6309 (2.6); 6.6205 (6.0); 6.6148 (10.7); 6.6091 (5.3); 6.5986 (3.2); 6.5929 (5.4); 6.5872 (2.7); 6.5502 (11.3); 6.5486 (14.6); 6.5467 (14.2); 5.9792 (2.9); 5.2140 (1.5); 5.1943 (5.5); 5.1770 (7.3); 5.1747 (7.4); 5.1573 (5.5); 5.1399 (1.4); 4.4931 (0.8); 4.4778 (0.9); 4.4540 (10.0); 4.4478 (10.1); 4.4395 (9.8); 4.4331 (9.5); 4.4092 (0.7); 4.3951 (0.8); 4.3314 (12.6); 4.3070 (13.5); 4.1476 (0.9); 4.1296 (2.2); 4.1118 (2.2); 4.0939 (0.6); 3.5695 (14.8); 3.5451 (13.8); 3.1458 (12.1); 3.1040 (14.0); 2.5520 (16.0); 2.5102 (13.9); 2.4891 (2.7); 2.4823 (3.8); 2.4753 (2.9); 2.4715 (3.2); 2.4690 (4.1); 2.4650 (6.2); 2.4622 (5.4); 2.4584 (6.4); 2.4517 (6.5); 2.4449 (6.5); 2.4412 (5.6); 2.4382 (6.8); 2.4344 (4.5); 2.4318 (4.0); 2.4280 (3.4); 2.4209 (4.4); 2.4144 (3.3); 2.1733 (1.7); 2.1663 (1.4); 2.1526 (3.1); 2.1477 (6.7); 2.1409 (4.5); 2.1330 (2.4); 2.1283 (6.8); 2.1236 (6.6); 2.1217 (6.8); 2.1170 (5.7); 2.1043 (4.8); 2.0973 (6.0); 2.0928 (2.9); 2.0796 (1.9); 2.0734 (1.7); 2.0425 (10.5); 1.8742 (1.6); 1.8468 (4.1); 1.8442 (3.2); 1.8250 (2.4); 1.8222 (4.1); 1.8196 (3.4); 1.7973 (1.5); 1.7949 (1.6); 1.7306 (1.8); 1.7104 (3.3); 1.7058 (2.8); 1.6901 (2.1); 1.6850 (6.1); 1.6784 (2.5); 1.6627 (2.6); 1.6576 (4.9); 1.6524 (1.6); 1.6381 (2.3); 1.6322 (2.4); 1.6120 (1.5); 1.5468 (74.1); 1.3324 (0.9); 1.2838 (1.3); 1.2760 (3.6); 1.2581 (8.4); 1.2402 (3.2); 0.8802 (0.8); 0.1569 (0.7); 0.1462 (0.9); 0.0079 (9.9); -0.0002 (333.0); -0.0085 (9.4); -0.0503 (0.8); -0.1499 (0.9). I.2-116: N-[(2-Chlorpyrimidin-4-yl)methyl]-1-(3,5-dichlorphenyl)-3-methyl-5-oxopyrrolidin-3- carboxamid
Figure imgf000114_0001
Zu einer Lösung aus 240.0 g (1.63 mol) 4-Methylpyrimidin-2(1H)-on Hydrochlorid in 500 mL Eisessig und 700 mL Dioxan gab man portionsweise 160.0 g (2.45 mol) Natriumnitrit. Danach wurde die Reaktionsmischung 3h bei Raumtemperatur gerührt. Man filtrierte den gebildeten Rückstand ab, wusch mit Wasser und trocknete. Man erhält 220.0 g (97% der Theorie) 4-[(Hydroxyimino)methyl]pyrimidin- 2(1H)-on als Isomerengemisch in Form eines gelblichen Feststoffs. MS-ESI: [M+H]+ 140.0.1H-NMR (500.0 MHz, d6-DMSO): δ= 6.67 (1H, d, J=6.5 Hz), 7.79 (1H, s), 7.93 (2H, d, J=6.5Hz), 11.87 (1H, s, NH), 12.50 (1H, s, OH). Zu 15.0 g (108.0 mmol) des Isomerengemisches 4- [(Hydroxyimino)methyl]pyrimidin-2(1H)-on in 270 mL Dioxan gab man 30 mL POCl3 (50.4g, 0.329 mol). Die Reaktionsmischung wurde über Nacht bei 95 °C gerührt, dann auf Raumtemperatur abgekühlt und auf 150 g Eis gegossen. Anschließend wurde mehrmals mit Ethylacetat extrahiert. Die vereinten organischen Phasen wurden mit wässriger NaHCO3-Lösung gewaschen (800mL), über Natriumsulfat getrocknet, filtriert und im Vakuum eingedampft. Der Rückstand wurde über Kieselgel chromatographiert (Petrolether: EtOAc = 10:1~4:1). Dieses Vorgehen wurde zehnmal wiederholt und man erhielt 97.0 g (65 % der Theorie) 2-Chlorpyrimidin-4-carbonitril als gelblichen Feststoff. MS-ESI: [M+H]+ 140.2.1H-NMR (500.0 MHz, d6-DMSO): δ= 8.90 (1H, d, J=5.0 Hz), 7.64 (2H, d, J=5.0 Hz). 75.0 g (540 mmol) 2-Chlorpyrimidin-4-carbonitril in 1500 mL Ethanol wurden mit 30.0 g 10% Pd/C in conc. HCl (25 mL) über einen Luftballon bei Raumtemperatur über Nacht hydriert. Nach Beendigung der Reaktion wurde vom Ungelösten abfiltriert, mit Ethanol nachgewaschen und im Vakuum eingedampft. Der Rückstand wurde in 1000 mL Dichlormethan suspendiert und bei 0 °C zuerst mit 80 mL (58.4 g, 0.577 mol) Triethylamin und dann mit 118.0 g (540.0 mmol) Di-tert-butyldicarbonat versetzt. Anschließend wurde noch 2 h bei Raumtemperatur nachgerührt und schließlich mit 200 mL Wasser gequencht. Die organische Phase wurde abgetrennt und im Vakuum eingedampft. Nach Chromatographie über Kieselgel (Petrolether: EtOAc = 10:1~6:1) erhielt man 67.5g (51.4 % der Theorie) tert-Butyl-[(2-chlorpyrimidin-4-yl)methyl]carbamat als weißen Feststoff.7.00 g (28.8 mmol) tert-Butyl-[(2-chlorpyrimidin-4-yl)methyl]carbamat in Essigsäureethylester (50 mL) wurden mit 20.0 mL Salzsäure (4M in Dioxan) versetzt und über Nacht bei Raumtemperatur gerührt. Nach Entfernen der Lösungsmittels im Vakuum erhielt man 5.00 g (96 % der Theorie) an 1-(2-Chlorpyrimidin-4- yl)methanamin Hydrochlorid als rosa Feststoff. MS-ESI: [M+H]+ 144.
Figure imgf000115_0001
DMSO): δ= 8.84 (d, J = 5.0 Hz, 4H), 7.76 (d, J = 5.0 Hz, 1H), 4.28-4.24 (m, 2H). Eine Mischung aus 24.9 g (0.154 mol) 3,5-Dichloranilin and 20.0 g (0.154 mol) Itaconsäure wurden zusammen bei 150 °C für 1 h erhitzt. Nach Beendigung der Reaktion wurde auf Raumtemperatur abgekühlt, mit Hexan (500 mL) versetzt und weitere 16 h gerührt. Der Feststoff wurde abfiltriert, mit Hexan gewaschen und im Vakuum bei 40 °C getrocknet. Man erhielt 30.0 g (71 % der Theorie) der 1-(3,5-Dichlorphenyl)-5- oxopyrrolidin-3-carbonsäure als braunen Feststoff. 30.0 g (0.109 mol) der oben erhaltenen 1-(3,5- Dichlorphenyl)-5-oxopyrrolidin-3-carbonsäure wurden in 120 mL Methanol gelöst und auf 0 °C abgekühlt. Anschließend wurde bei dieser Temperatur mit 471 mg (0.4 mL =6.0 mmol) Acetylchlorid und 11.6 g (12.0 mL =109 mmol) Trimethylorthoformat behandelt und danach für 1 h auf 64 °C erhitzt. Anschließend wurde die Reaktionsmischung im Vakuum eingedampft und der Rückstand in 750 mL Dichlormethan gelöst. Nach Waschen mit 500 mL gesättigter wässriger Natriumhydrogencarbonat- lösung und 300 mL Kochsalzlösung und Trocknen über Natriumsulfat erhielt man ein Rohprodukt, welches über Kieselgel chromatographisch gereinigt wurde. Man erhielt 20.0 g (64 % der Theorie) an Methyl-1-(3,5-dichlorphenyl)-5-oxopyrrolidin-3-carboxylat als weißen Feststoff. Unter Argon wurden 20.0 g (0.069 mol) des oben erhaltenen Methyl-1-(3,5-dichlorphenyl)-5-oxopyrrolidin-3-carboxylats in 300 mL trockenem DMF gelöst. Zu dieser Lösung gab man über einen Zeitraum von 20 min 3.30 g (0.083 mol) 60%iges Natriumhydrid und anschließend bei 0 °C 24.71 g (0.174 mol) Methyliodid. Anschließend wurde auf 10 °C erwärmt und 3 h bei dieser Temperatur gerührt. Nach beendeter Reaktion wurde mit 300 mL gesättigter Ammoniumchloridlösung hydrolysiert und zweimal mit je 500 mL MTBE extrahiert. Die vereinten organischen Phasen wurden über Natriumsulfat getrocknet, filtriert und im Vakuum eingeengt. Der Rückstand wurde in Dichlormethan gelöst und über Silicagel chromatographiert. Man erhielt 7.50 g (36 % der Theorie) an Methyl-1-(3,5-dichlorphenyl)-3-methyl-5- oxopyrrolidin-3-carboxylat als grünliches Öl. Eine Suspension aus 7.50 g (0.025 mol) oben erhaltenem Methyl-1-(3,5-dichlorphenyl)-3-methyl-5-oxopyrrolidin-3-carboxylat in 40 mL Methanol und 40 mL Wasser wurde mit 10.4 g (0.248 mol) Lithiumhydroxid bei Raumtemperatur versetzt und zunächst bei Raumtemperatur und dann 1 h bei 80 °C erhitzt. Nach beendeter Reaktion wurde abgekühlt und das Solvens im Vakuum abgedampft. Der Rückstand wurde mit 100 mL Wasser aufgenommen und zweimal mit je 150 mL MTBE gewaschen. Danach wurde der pH der verbleibenden wässrigen Phase mit 2N Salzsäure auf 3-4 eingestellt und die wässrige Phase zweimal mit je 500 mL Ethylacetat extrahiert. Nach Trocknen der vereinten Essigesterphasen über Natriumsulfat wurde filtriert und das Solvens im Vakuum entfernt. Der Rückstand wurde in 50 mL Hexan suspendiert (5 h), abfiltiert und mit Hexan gewaschen. Man erhielt 5.40 g (Reinheit 98 %, 76% der Theorie) der gewünschten 1-(3,5- Dichlorphenyl)-3-methyl-5-oxopyrrolidin-3-carbonsäure als farblosen Feststoff.1H-NMR (400.0 MHz, d1-Chlorform): δ= 1.55 (s, 3H), 2.57 (d, J=17.33 Hz, 1H), 3.17 (d, J=17.33 Hz, 1H), 3.62 (d, J=10.01 Hz, 1H), 4.26 (d, J=10.01 Hz, 1H), 7.15 (d, J=1.75 Hz, 1H) 7.56 (t, J=1.83 Hz, 2H). Unter Stickstoff wurden 80 mg (0.27 mmol) 1-(3,5-Dichlorphenyl)-3-methyl-5-oxopyrrolidin-3-carbonsäure in 4 mL trockenem THF vorgelegt, dann nacheinander mit 37.5 mg (0.27 mmol) HOBT in 1 ml THF, 55.5 mg (0.30 mmol) 1-(2-Chlorpyrimidin-4-yl)methanamin Hydrochlorid, 143.5 mg (1.11 mmol) Ethyldiisopropylamin und zuletzt mit 69.2 mg (0.36 mmol) EDCl in 5 mL THF versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung eingedampft, mit Dichlormethan aufgenommen und mit Phosphatpuffer (pH5.5) gewaschen. Nach Trocknen über Natriumsulfat und Entfernen des Lösungsmittels im Vakuum wurde das Produkt in Dichlormethan aufgenommen und über Kieselgel chromatographiert. Nach Reinigung über Kieselgel wurden 50 mg (Reinheit 97 %, 42% der Theorie) des Produktes N-[(2-Chlorpyrimidin-4-yl)methyl]-1-(3,5-dichlorphenyl)-3-methyl-5- oxopyrrolidin-3-carboxamid als ein orangefarbener, halbfester Feststoff erhalten.1H-NMR (400.6 MHz, CDCl3): δ 8.6053 (7.4); 8.5926 (7.5); 7.5987 (15.7); 7.5942 (16.0); 7.5197 (1.8); 7.2855 (1.4); 7.2613 (327.8); 7.2538 (1.6); 7.2522 (1.3); 7.2482 (5.3); 7.2355 (4.5); 7.2341 (2.6); 7.1599 (4.0); 7.1554 (7.6); 7.1509 (3.8); 6.9976 (1.8); 6.7821 (1.0); 4.5968 (3.9); 4.5923 (3.8); 4.5911 (3.8); 4.5836 (3.8); 4.5792 (3.7); 4.3219 (3.9); 4.2975 (4.1); 4.1308 (1.0); 4.1130 (1.0); 3.6004 (4.5); 3.5760 (4.1); 3.1870 (3.8); 3.1449 (4.3); 2.5936 (4.9); 2.5515 (4.2); 2.1367 (4.8); 2.1007 (5.3); 2.0456 (4.9); 1.5900 (21.5); 1.5608 (35.5); 1.4400 (2.4); 1.4258 (2.3); 1.3324 (0.9); 1.2843 (1.4); 1.2775 (1.7); 1.2597 (4.0); 1.2419 (1.6); 0.0080 (3.6); -0.0002 (108.9); -0.0085 (3.2). I.2-121: N-Benzyl-6-(3,5-dichlorphenyl)-N,2,4-trimethyl-7-oxo-6-azabicyclo[3.2.1]oct-3-en-8- carboxamid
Figure imgf000116_0001
Unter Stickstoff wurden 51.0 mg (0.15 mmol) 6-(3,5-Dichlorphenyl)-2,4-dimethyl-7-oxo-6- azabicyclo[3.2.1]oct-3-en-8-carbonsäure in 2 mL trockenem Dichlormethan vorgelegt, dann nacheinander mit 20.3 mg (0.15 mmol) HOBT in 0.5 mL Dichlormethan, 20.0 mg (0.17 mmol) N- Methyl-1-phenylmethanamin, 58.2 mg (0.45 mmol) Ethyldiisopropylamin und zuletzt mit 37.4 mg (0.2 mmol) EDCl versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung filtriert, zweimal mit Wasser gewaschen, die organische Phase getrocknet und einrotiert. Nach Reinigung über eine präparative HPLC wurden 35.7 mg (Reinheit 97%, 52% der Theorie) des Produktes N-Benzyl-6- (3,5-dichlorphenyl)-N,2,4-trimethyl-7-oxo-6-azabicyclo[3.2.1]oct-3-en-8-carboxamid erhalten.1H-NMR (400.0 MHz, CDCl3): δ 7.5915 (6.1); 7.5870 (6.3); 7.5502 (2.8); 7.5458 (2.8); 7.4354 (0.5); 7.4181 (1.4); 7.3994 (1.2); 7.3766 (0.7); 7.3588 (0.7); 7.2960 (0.6); 7.2921 (0.7); 7.2840 (2.2); 7.2770 (1.7); 7.2699 (4.4); 7.2659 (5.0); 7.2600 (54.5); 7.1812 (3.3); 7.1740 (2.2); 7.1668 (2.4); 7.1627 (2.5); 7.1197 (1.7); 7.1152 (3.0); 7.1107 (1.6); 7.0874 (0.8); 7.0831 (1.3); 7.0787 (0.7); 5.3549 (1.5); 5.3518 (1.5); 5.2782 (0.8); 4.8428 (1.6); 4.8064 (1.8); 4.6588 (0.5); 4.6172 (1.0); 4.5208 (1.0); 4.4792 (0.5); 4.3726 (2.4); 4.3352 (2.0); 4.2988 (1.7); 4.2651 (1.2); 3.4891 (7.9); 3.2234 (3.7); 3.1902 (1.7); 2.9895 (1.4); 2.9771 (1.5); 2.9582 (7.8); 2.9517 (16.0); 2.9361 (0.9); 2.7593 (0.5); 2.7535 (0.6); 2.7472 (0.6); 2.7413 (0.5); 1.8643 (4.3); 1.8593 (6.1); 1.8545 (4.4); 1.7465 (2.3); 1.7420 (3.2); 1.7373 (2.2); 1.6370 (1.2); 1.2090 (6.1); 1.1909 (6.0); 1.1487 (3.0); 1.1305 (2.9); 0.0080 (0.7); -0.0002 (21.6); -0.0085 (0.6). I.2-142: 1-(3-Chlor-5-methylphenyl)-N-[(2-chlorpyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidin-3- carboxamid
Figure imgf000117_0001
Eine Mischung aus 18.5 g (0.131 mol) 3-Chlor-5-methylanilin and 17.0 g (0.131 mol) Itaconsäure wurden zusammen bei 130 °C für 1 h erhitzt. Nach Beendigung der Reaktion wurde bei ca.70 °C mit MTBE (50 mL) versetzt und auf Raumtemperatur abgekühlt. Anschließend wurde mit 400 mL Hexan versetzt und weitere 2 h gerührt, der Feststoff abfiltriert, mit Hexan (100 mL) gewaschen und im Vakuum bei 40 °C getrocknet. Man erhielt 30.0 g (91 % der Theorie) der 1-(3-Chlor-5-methylphenyl)-5- oxopyrrolidin-3-carbonsäure als braunen Feststoff.31.0 g (0.122 mol) der oben erhaltenen 1-(3-Chlor-5- methylphenyl)-5-oxopyrrolidin-3-carbonsäure wurden in 150 mL Methanol gelöst und auf 0 °C abgekühlt. Anschließend wurde bei dieser Temperatur mit 471.0 mg (0.43 mL =6.0 mmol) Acetylchlorid und 12.96 g (13.3 mL = 0.122 mol) Trimethylorthoformat behandelt und danach für 1 h auf 64 °C erhitzt. Anschließend wurde die Reaktionsmischung im Vakuum eingedampft und der Rückstand in 750 mL Dichlormethan gelöst. Nach Waschen mit 500 mL gesättigter wässriger Natriumhydrogencarbonatlösung und 300 mL Kochsalzlösung und Trocknen über Natriumsulfat erhielt man ein Rohprodukt, welches über Kieselgel chromatographisch gereinigt wurde. Man erhielt 28.0 g (86 % der Theorie) an Methyl-1-(3-chlor-5-methylphenyl)-5-oxopyrrolidin-3-carboxylat als weißen Feststoff. Unter Argon wurden 23.0 g (0.086 mol) des oben erhaltenen Methyl-1-(3-chlor-5- methylphenyl)-3-methyl-5-oxopyrrolidin-3-carboxylats in 250 mL trockenem DMF gelöst und bei 0 °C mit 4.50 g (0.122 mol) 60%iges Natriumhydrid und dann mit 36.62 g (0.258 mol) Methyliodid versetzt. Anschließend wurde 1 h bei 0 °C weitergerührt und auf Raumtemperatur erwärmt. Nach 16 h wurde mit 300 mL gesättigter Ammoniumchloridlösung hydrolysiert und zweimal mit je 300 mL MTBE extrahiert. Die vereinten organischen Phasen wurden über Natriumsulfat getrocknet, filtriert und im Vakuum eingeengt. Der Rückstand wurde in Dichlormethan gelöst und über Silicagel chromatographiert. Man erhielt 8.0 g (33 % der Theorie) an Methyl-1-(3-chlor-5-methylphenyl)-3-methyl-5-oxopyrrolidin-3- carboxylat als grünliches Öl. Eine Suspension aus 8.90 g (0.028 mol) oben erhaltenem Methyl-1-(3- chlor-5-methylphenyl)-3-methyl-5-oxopyrrolidin-3-carboxylats in 50 mL Methanol und 50 mL Wasser wurde mit 11.9 g (0.283 mol) Lithiumhydroxid bei Raumtemperatur versetzt und zunächst bei Raumtemperatur und dann 1 h bei 80 °C erhitzt. Nach beendeter Reaktion wurde abgekühlt und das Solvens im Vakuum abgedampft. Der Rückstand wurde mit 100 mL Wasser aufgenommen und zweimal mit je 100 mL MTBE gewaschen. Danach wurde der pH der verbleibenden wässrigen Phase mit 2N Salzsäure auf 3-4 eingestellt und die wässrige Phase dreimal mit je 500 mL Ethylacetat extrahiert. Nach Trocknen der vereinten Essigesterphasen wurde filtriert und das Solvens im Vakuum entfernt. Der feste Rückstand wurde in 250 mL Hexan suspendiert (5 h), abfiltiert und mit Hexan gewaschen. Nach Trocknen bei 40 °C erhielt man 6.50 g (Reinheit 96.5 %, 86 % der Theorie) der gewünschten 1-(3-Chlor-5-methylphenyl)-3-methyl-5-oxopyrrolidin-3-carbonsäure als farblosen Feststoff.1H-NMR (400.0 MHz, d1-Chlorform): δ = 2.34 (s, 3 H) 2.56 (d, J=17.33 Hz, 1 H) 3.17 (d, J=17.33 Hz, 1 H) 3.63 (d, J=10.01 Hz, 1 H) 4.27 (d, J=10.01 Hz, 1 H) 6.99 (br s, 1 H) 7.32 (br s, 1 H) 7.41 (br s, 1 H). Unter Stickstoff wurden 70 mg (0.26 mmol) 1-(3-Chlor-5-methylphenyl)-3-methyl-5- oxopyrrolidin-3-carbonsäure in 4 mL trockenem THF vorgelegt, dann nacheinander mit 35.3 mg (0.26 mmol) HOBT in 1 ml THF, 61.5 mg (0.34 mmol) 2-Chlorpyridin-4-yl)methanaminiumchlorid, 135.2 mg (1.04 mmol) Ethyldiisopropylamin und zuletzt mit 65.2 mg (0.34 mmol) EDCl in 5 mL THF versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung eingedampft, das Rohprodukt in 2.5 mL Dichlormethan aufgenommen und direkt über Kieselgel gereinigt. Nach Reinigung über Kieselgel wurden 99.0 mg (Reinheit 91 %, 88 % der Theorie) an 1-(3-Chlor-5-methylphenyl)-N-[(2- chlorpyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidin-3-carboxamid als gelbes Harz erhalten.1H- NMR(400.0 MHz, CDCl3): δ 8.3342 (2.9); 8.3215 (2.9); 7.4361 (1.8); 7.4323 (3.2); 7.4276 (1.9); 7.2872 (2.9); 7.2628 (37.6); 7.1940 (3.5); 7.1924 (3.5); 7.1048 (2.0); 7.1031 (1.8); 7.1012 (1.9); 7.0920 (1.9); 7.0885 (1.8); 6.9815 (3.0); 6.3794 (0.8); 4.4895 (2.2); 4.4756 (3.7); 4.4614 (2.1); 4.3291 (3.1); 4.3044 (3.3); 4.1440 (0.9); 4.1262 (2.6); 4.1083 (2.7); 4.0904 (0.9); 3.5933 (3.6); 3.5686 (3.4); 3.0964 (2.9); 3.0547 (3.3); 2.9516 (0.9); 2.8673 (0.8); 2.5411 (3.7); 2.4994 (3.2); 2.3330 (16.0); 2.3320 (15.8); 2.0412 (12.3); 1.5458 (16.6); 1.2815 (0.5); 1.2752 (3.6); 1.2573 (8.0); 1.2395 (3.5); -0.0002 (13.4) I.3-4: 2-(2,5-Dimethylphenyl)-N-[1-(chinolin-8-yl)-5-oxopyrrolidin-3-yl]acetamid.
Figure imgf000119_0001
Itaconsäure (100 mmol, 1 Äquiv.) und 8-Aminochinolin (100 mmol, 1 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben und 16 h lang bei bei einer Temperatur von 150 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt Durch Umkristallisieren aus Essigester wurde 1-(2-Fluorphenyl)-5-oxopyrrolidin-3- carbonsäure in Form eines farblosen Feststoffs erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt.1-(Chinolin-8-yl)-5-oxopyrrolidin-3-carbonsäure (48.8 mmol, 1 Äquiv.) wurde in tert. Butanol (100 mL) gelöst und mit Diphenylphosphorylazid (58.8 mmol, 1.2 Äquiv.) und Triethylamin (146.4 mmol, 3.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 2 h lang bei 80 °C gerührt, nach dem Abkühlen auf Raumtemperatur unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in einem Gemisch aus Salzsäure und Essigester (100 mL) aufgenommen und 16 h lang bei Raumtemperatur gerührt. Der ausgefallene Feststoff wurde abfiltriert und getrocknet. Auf diese Weise konnte 4-Amino-1-(chinolin-8-yl)pyrrolidin-2-on als Hydrochloridsalz in Form eines farblosen Feststoffs erhalten werden.4-Amino-1-(chinolin-8-yl)pyrrolidin-2-on Hydrochloridsalz (150 mg, 0.57 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.19 mL, 1.42 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2,5-Dimethylphenylessigsäurechlorid (114 mg, 0.63 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 2-(2,5-Dimethylphenyl)-N-[1-(chinolin-8-yl)-5-oxopyrrolidin-3-yl]acetamid (189 mg, 89% der Theorie) in Form eines farblosen Feststoffs erhalten.1H-NMR (400 MHz, d6-DMSO) δ ppm 8.91 (m, 1H), 8.64 (br. d, 1H, NH), 8.46 (dd, 1H), 7.99 (m, 1H), 7.75 (d, 1H), 7.66 (dd, 1H), 7.60 (dd, 1H), 7.04-6.98 (m, 2H), 6.92 (m, 1H), 4.59-4.53 (m, 1H), 4.31-4.27 (dd, 1H), 3.80-3.76 (dd, 1H), 3.46 (s, 2H), 2.93-2.88 (dd, 1H), 2.46-2.39 (dd, 1H), 2.22 (s, 3H). I.3-13: 2-(2,5-Dichlorphenyl)-N-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]acetamid.
Figure imgf000120_0001
Itaconsäure (100 mmol, 1 Äquiv.) und 2-Fluoranilin (100 mmol, 1 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben und 16 h lang bei bei einer Temperatur von 150 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt Durch Umkristallisieren aus Essigester wurde 1-(2-Fluorphenyl)-5-oxopyrrolidin-3-carbonsäure in Form eines farblosen Feststoffs erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt. 1-(2-Fluorphenyl)-5-oxopyrrolidin-3-carbonsäure (48.8 mmol, 1 Äquiv.) wurde in tert. Butanol (100 mL) gelöst und mit Diphenylphosphorylazid (58.8 mmol, 1.2 Äquiv.) und Triethylamin (146.4 mmol, 3.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 2 h lang bei 80 °C gerührt, nach dem Abkühlen auf Raumtemperatur unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in einem Gemisch aus Salzsäure und Essigester (100 mL) aufgenommen und 16 h lang bei Raumtemperatur gerührt. Der ausgefallene Feststoff wurde abfiltriert und getrocknet. Auf diese Weise konnte 4-Amino-1-(2-fluorphenyl)pyrrolidin-2-on in Form eines farblosen Feststoffs erhalten werden.4-Amino-1-(2-fluorphenyl)pyrrolidin-2-on (150 mg, 0.65 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.23 mL, 1.63 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2,5- Dichlorphenylessigsäurechlorid (160 mg, 0.72 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 2-(2,5-Dichlorphenyl)-N-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]acetamid (93 mg, 38% der Theorie) in Form eines farblosen Feststoffs erhalten.1H- NMR (400 MHz, CDCl3) δ ppm 7.38-7.30 (m, 3H), 7.28-7.08 (m, 4H), 5.91-5.84 (br. m, 1H, NH), 4.75- 4.67 (m, 1H), 4.14-4.10 (m, 1H), 3.69-3.63 (m, 3H), 2.98-2.92 (dd, 1H), 2.45-2.39 (dd, 1H). I.3-14: 2-(2,5-Dichlorphenyl)-N-[1-(chinolin-8-yl)-5-oxopyrrolidin-3-yl]acetamid.
Figure imgf000121_0001
4-Amino-1-(chinolin-8-yl)pyrrolidin-2-on Hydrochloridsalz (150 mg, 0.57 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.19 mL, 1.42 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2,5- Dichlorphenylessigsäurechlorid (140 mg, 0.63 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 2-(2,5-Dichlorphenyl)-N-[1-(chinolin-8-yl)-5- oxopyrrolidin-3-yl]acetamid (156 mg, 66% der Theorie) in Form eines farblosen Feststoffs erhalten.1H- NMR (400 MHz, d6-DMSO) δ ppm 8.93 (m, 1H), 8.80 (br. d, 1H, NH), 8.46 (dd, 1H), 7.99 (m, 1H), 7.75 (d, 1H), 7.67 (dd, 1H), 7.61 (dd, 1H), 7.51 (m, 1H), 7.44 (m, 1H), 7.35 (m, 1H), 4.62-4.57 (m, 1H), 4.31-4.27 (dd, 1H), 3.81-3.78 (dd, 1H), 3.67 (s, 2H), 2.94-2.88 (dd, 1H), 2.49-2.43 (dd, 1H). I.3-19: 2-(2,5-Dichlorphenyl)-N-[1-cyclopropyl-5-oxopyrrolidin-3-yl]acetamid.
Figure imgf000121_0002
Itaconsäure (100 mmol, 1 Äquiv.) und Cyclopropylamin (100 mmol, 1 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben und 16 h lang bei bei einer Temperatur von 150 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt Durch Umkristallisieren aus Essigester wurde 1-Cyclopropyl-5-oxopyrrolidin-3-carbonsäure in Form eines farblosen Feststoffs erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt.1-Cyclopropyl-5-oxopyrrolidin-3-carbonsäure (48.8 mmol, 1 Äquiv.) wurde in tert. Butanol (100 mL) gelöst und mit Diphenylphosphorylazid (58.8 mmol, 1.2 Äquiv.) und Triethylamin (146.4 mmol, 3.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 2 h lang bei 80 °C gerührt, nach dem Abkühlen auf Raumtemperatur unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in einem Gemisch aus Salzsäure und Essigester (100 mL) aufgenommen und 16 h lang bei Raumtemperatur gerührt. Der ausgefallene Feststoff wurde abfiltriert und getrocknet. Auf diese Weise konnte 4-Amino-1-cyclopropylpyrrolidin-2-on als Hydrochloridsalz in Form eines farblosen Feststoffs erhalten werden.4-Amino-1-cyclopropyl-pyrrolidin-2-on Hydrochloridsalz (150 mg, 0.85 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.30 mL, 2.12 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2,5-Dichlorphenylessigsäurechlorid (209 mg, 0.93 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 2-(2,5-Dichlorphenyl)-N-[1- cyclopropyl-5-oxopyrrolidin-3-yl]acetamid (222 mg, 80% der Theorie) in Form eines farblosen Feststoffs erhalten.1H-NMR (400 MHz, CDCl3) δ ppm 7.34-7.30 (m, 2H), 7.28-7.23 (m, 1H), 5.96-5.89 (br. m, 1H, NH), 4.52-4.43 (m, 1H), 3.67-3.64 (m, 1H), 3.63 (s, 2H), 3.15-3.10 (dd, 1H), 2.78-2.72 (dd, 1H), 2.65-2.61 (m, 1H), 2.23-2.18 (dd, 1H), 0.78-0-70 (m, 2H), 0.69-0.59 (m, 2H). I.4-33: 1-(4-Chlorphenyl)-3-[4-methyl-1-phenyl-5-oxopyrrolidin-3-yl]harnstoff.
Figure imgf000122_0001
N-Phenylglycinethylester (60 mmol, 1 Äquiv.) und Diisopropylethylamin (120 mmol, 2 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben, in abs. Dichlormethan gelöst (150 mL) und mit Propionylchlorid (120 mmol, 2 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 16 h lang bei bei Raumtemperatur gerührt und danach unter vermindertem Druck eingeengt Nach der Zugabe von gesättigter Natriumhydrogencarbonatlösung und von Essigester wurde die wässrige Phase dreimal mit Essigester extrahiert (200 mL insgesamt). Durch Trocknen der vereinigten organischen Phasen über Natriumsulfat, Abflitrieren und Einengen unter vermindertem Druck wurde N-Propionyl-N- phenylglcinethylester erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt. N- Propionyl-N-phenylglcinethylester (60 mmol, 1.0 Äquiv.) wurde in abs. Tetrahydrofuran gelöst und vorsichtig mit Natriumhydrid (180 mmol, 3 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 48 h lang bei einer Temperatur von 65 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde die Reaktionsmischung durch tropfenweise Zugabe von Ethanol gequencht und danach unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbleibenden Rückstandes (20% Petrolether/Essigester) wurde 1-Phenyl-3,5-dioxo-4-methylpyrrolidin in Form eines farblosen Feststoffs erhalten.1-Phenyl-3,5-dioxo-4-methylpyrrolidin (30.0 mmol, 1 Äquiv.) wurde in Dichlormethan (100 mL) gelöst und mit Hydroxylaminhydrochlorid (36.0 mmol, 1.2 Äquiv.) sowie Diisopropylethylamin (60 mmol, 2.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 16 h lang bei Raumtemperatur gerührt, unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in Methanol (100 mL) aufgenommen, mit Palladium auf Kohle (1.0 g) versetzt und 16 h lang bei Raumtemperatur under einer Wasserstoffatmosphäre (1 bar) gerührt. Danach wurde das Reaktionsgemisch über Celite filtriert und unter vermindertem Druck eingeengt. Der Rückstand wurde in Essigsäure aufgenommen (50 mL) und mit Natriumcyanoborhydrid (60 mmol, 2 Äquiv.) versetzt. Das Reaktionsgemisch wurde weitere 16 h lang bei Raumtemperatur gerührt und erneut eingeengt. Durch säulenchromatographische Reinigung des verbleibenden Rückstandes (20% Petrolether/Essigester) wurde 3-Amino-4-methyl-1-phenyl-5-oxopyrrolidin in Form eines farblosen Feststoffs erhalten.3- Amino-4-methyl-1-phenyl-5-oxopyrrolidin (1.0 mmol, 1 Äquiv.) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Diisopropylethylamin (2.0 mmol, 2 Äquiv.) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die tropfenweise Zugabe einer Lösung von 4-Chlorphenylisocyanat (1.2 mmol, 1.2 Äquiv.) in abs. Dichlormethan (2 mL). Das resultierende Reaktionsgemisch wurde 16 h bei Raumtemperatur gerührt und danach unter vermindertem Druck eingeeingt. Durch präparative HPLC-Reinigung des erhaltenen Rohproduktes wurde 1-(4-Chlorphenyl)- 3-[4-methyl-1-phenyl-5-oxopyrrolidin-3-yl]harnstoff (213 mg, 62% der Theorie) in Form eines farblosen Feststoffs erhalten.1H-NMR (400 MHz, d6-DMSO) δ ppm 8.80 (br. s, 1H, NH), 7.69 (d, 2H), 7.47-7.38 (m, 4H), 7.30 (d, 2H), 7.17-7.13 (m, 1H), 6.76 (br. d, 1H, NH), 4.12-4.03 (m, 2H), 3.61-3.58 (m, 1H), 2.69-2.61 (m, 1H), 1.20 (d, 3H). I.4-36: 1-(5-Chlor-2-methylphenyl)-3-[1-phenyl-5-oxopyrrolidin-3-yl]harnstoff.
Figure imgf000123_0001
Itaconsäure (100 mmol, 1 Äquiv.) und Anilin (100 mmol, 1 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben und 16 h lang bei bei einer Temperatur von 150 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt Durch Umkristallisieren aus Essigester wurde 1-Phenyl-5-oxopyrrolidin-3-carbonsäure in Form eines farblosen Feststoffs erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt. Phenyl-5-oxopyrrolidin-3-carbonsäure (48.8 mmol, 1 Äquiv.) wurde in tert. Butanol (100 mL) gelöst und mit Diphenylphosphorylazid (58.8 mmol, 1.2 Äquiv.) und Triethylamin (146.4 mmol, 3.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 2 h lang bei 80 °C gerührt, nach dem Abkühlen auf Raumtemperatur unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in einem Gemisch aus Salzsäure und Essigester (100 mL) aufgenommen und 16 h lang bei Raumtemperatur gerührt. Der ausgefallene Feststoff wurde abfiltriert und getrocknet. Auf diese Weise konnte 4-Amino-1-phenylpyrrolidin-2-on als Hydrochloridsalz in Form eines farblosen Feststoffs erhalten werden.4-Amino-1-phenylpyrrolidin-2-on Hydrochlorid (7.05 g, 33 mmol) wurde in einem ausgeheizten Rundkolben in abs. Acetonitril (20 mL) gelöst und mit Triethylamin (6.01 mL, 43.09 mmol) versetzt sowie auf 10 °C eingekühlt. Nach 10 Minuten Rühren bei einer Temperatur von 10 °C erfolgte die tropfenweise Zugabe einer Lösung von 5-Chlor-2-methylphenylisocyanat (5.00 g, 29.83 mmol). Das resultierende Reaktionsgemisch wurde 4 h bei Raumtemperatur gerührt, mit Essigester, Wasser und verd. Salzsäure versetzt und die wässrige Phase gründlich mit Essigester extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch präparative HPLC-Reinigung des erhaltenen Rohproduktes wurde 1-(5-Chlor-2-methylphenyl)-3-[1-phenyl-5-oxopyrrolidin-3-yl]harnstoff (7.75 g, 68% der Theorie) in Form eines farblosen Feststoffs erhalten.1H-NMR (400 MHz, d6-DMSO) δ ppm 8.06 (d, 1H), 7.73 (br. s, 1H, NH), 7.68 (m, 2H), 7.41-7.36 (m, 2H), 7.30 (d, 1H), 7.16-7.12 (m, 2H), 6.92-6.69 (m, 1H), 4.41-4.36 (m, 1H), 4.18-4.14 (m, 1H), 3.70-3.66 (dd, 1H), 3.00-2.94 (dd, 1H), 2.43-2.38 (dd, 1H), 2.14 (s, 3H). I.5-4: 1-(2,5-Dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff.
Figure imgf000124_0001
Itaconsäure (100 mmol, 1 Äquiv.) und 2-Fluoranilin (100 mmol, 1 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben und 16 h lang bei bei einer Temperatur von 150 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt Durch Umkristallisieren aus Essigester wurde 1-(2-Fluorphenyl)-5-oxopyrrolidin-3-carbonsäure in Form eines farblosen Feststoffs erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt. 1-(2-Fluorphenyl)-5-oxopyrrolidin-3-carbonsäure (48.8 mmol, 1 Äquiv.) wurde in tert. Butanol (100 mL) gelöst und mit Diphenylphosphorylazid (58.8 mmol, 1.2 Äquiv.) und Triethylamin (146.4 mmol, 3.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 2 h lang bei 80 °C gerührt, nach dem Abkühlen auf Raumtemperatur unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in einem Gemisch aus Salzsäure und Essigester (100 mL) aufgenommen und 16 h lang bei Raumtemperatur gerührt. Der ausgefallene Feststoff wurde abfiltriert und getrocknet. Auf diese Weise konnte 4-Amino-1-(2-fluorphenyl)pyrrolidin-2-on in Form eines farblosen Feststoffs erhalten werden.4-Amino-1-(2-fluorphenyl)pyrrolidin-2-on (150 mg, 0.65 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.23 mL, 1.63 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2,5-Dichlorphenylisothiocyanat (146 mg, 0.72 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 1-(2,5-Dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff (176 mg, 68% der Theorie) in Form eines farblosen Feststoffs erhalten.1H-NMR (400 MHz, CDCl3) δ ppm 7.86 (br. d, 1H, NH), 7.75 (br. s, 1H, NH), 7.45-7.30 (m, 3H), 7.28-7.08 (m, 4H), 5.16-5.11 (m, 1H), 4.23-4.19 (m, 1H), 3.97-3.93 (dd, 1H), 3.11-3.04 (dd, 1H), 2.53-2.48 (dd, 1H). I.5-10: 1-(5-Chlor-2-methylphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff.
Figure imgf000125_0001
4-Amino-1-(2-fluorphenyl)pyrrolidin-2-on (150 mg, 0.65 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.23 mL, 1.63 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2-Methyl-5- Chlorphenylisothiocyanat (132 mg, 0.72 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 1-(5-Chlor-2-methylphenyl)-3-[1-(2- fluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff (206 mg, 84% der Theorie) in Form eines farblosen Feststoffs erhalten.1H-NMR (400 MHz, CDCl3) δ ppm 7.52 (br. s, 1H, NH), 7.35-7.22 (m, 4H), 7.18- 7.10 (m, 3H), 6.01 (br. d, 1H, NH), 5.21-5.17 (m, 1H), 4.23-4.18 (m, 1H), 3.84-3.80 (dd, 1H), 3.05-2.99 (dd, 1H), 2.45-2.40 (dd, 1H), 2.24 (s, 3H). I.5-21: 1-(5-Chlor-2-methylphenyl)-3-[1-cyclopropyl-5-oxopyrrolidin-3-yl]thioharnstoff.
Figure imgf000125_0002
4-Amino-1-cyclopropylpyrrolidin-2-on (150 mg, 0.85 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.30 mL, 2.12 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2-Methyl-5-Chlorphenylisothiocyanat (172 mg, 0.93 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 1-(5-Chlor-2-methylphenyl)-3-[1-cyclopropyl-5-oxopyrrolidin-3-yl]thioharnstoff (213 mg, 77% der Theorie) in Form eines farblosen Feststoffs erhalten. 1H-NMR (400 MHz, d6-DMSO) δ ppm 9.07 (br. s, 1H, NH), 8.18-8.10 (br. s, 1H, NH), 7.41 (m, 1H), 7.26 (m, 1H), 7.19 (m, 1H), 4.80-4.72 (m, 1H), 3.63- 3.59 (dd, 1H), 3.16-3.12 (dd, 1H), 2.64-2.60 (m, 1H), 2.32 (m, 1H), 2.28-2.24 (dd, 1H), 2.14 (s, 3H), 0.67- 0.60 (m, 4H). I.5-34: 2-(5-Chlor-2-methylphenyl)-N-[1-(chinolin-8-yl)-5-oxopyrrolidin-3-yl]thioharnstoff.
Figure imgf000126_0001
4-Amino-1-(chinolin-8-yl)pyrrolidin-2-on Hydrochloridsalz (150 mg, 0.57 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.19 mL, 1.42 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 5-Chlor-2- methylphenylisothiocyanat (115 mg, 0.63 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 2-(5-Chlor-2-methylphenyl)-N-[1-(chinolin-8- yl)-5-oxopyrrolidin-3-yl]thioharnstoff (100 mg, 43% der Theorie) in Form eines farblosen Feststoffs erhalten.1H-NMR (400 MHz, d6-DMSO) δ ppm 9.24 (m, 1H), 8.87 (m, 1H), 8.46 (dd, 1H), 8.42-8.33 (br. s, 1H, NH), 7.99 (m, 1H), 7.74 (d, 1H), 7.68-7.64 (dd, 1H), 7.61 (dd, 1H), 7.51 (m, 1H), 7.44 (m, 1H), 7.27 (m, 1H), 7.21 (m, 1H), 5.14-5.08 (m, 1H), 4.37-4.33 (dd, 1H), 3.97-3.94 (dd, 1H), 3.02-2.96 (dd, 1H), 2.68-2.59 (dd, 1H), 2.18 (s, 3H). In Analogie zu den oben angeführten und an entsprechender Stelle rezitierten Herstellungsbeispielen und unter Berücksichtigung der allgemeinen Angaben zur Herstellung von Pyrrolidinonen der allgemeinen Formel (I) erhält man die nachfolgend genannten Verbindungen, Tabelle I.1: Bevorzugt für die Verwendung von Verbindungen der Formel (I.1) sind die Verbindungen I.1-1 bis I.1-605, worin R1, R4, R13 und X die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.1 haben und R3, R5, R6, R7 und R14 Wasserstoff sind und worin X für eine Gruppierung O-R36 oder N(R15)R35 steht. Die Stereochemie am Kohlenstoff C-2 wird mit „RAC“ für ein Gemisch beider Stereokonfigurationen am Kohlenstoff C-2, „Ent-1“ und „Ent-2“ für jeweils ein Enantiomer (oder Diastereomer bei mehreren Stereozentren im Molekül) mit einer definierten Stereokonfiguration am Kohlenstoff C-2 angegeben.
Figure imgf000127_0001
Tabelle I.1
Figure imgf000127_0002
Figure imgf000128_0001
Figure imgf000129_0001
Figure imgf000130_0001
Figure imgf000131_0001
Figure imgf000132_0001
Figure imgf000133_0001
Figure imgf000134_0001
Figure imgf000135_0001
Figure imgf000136_0001
Figure imgf000137_0001
Figure imgf000138_0001
Figure imgf000139_0001
Figure imgf000140_0001
Figure imgf000141_0001
?( 4 >(&
Figure imgf000089_0001
( 2 if 0 •
Figure imgf000090_0001
The heterocycles listed above are preferably substituted, for example, by hydrogen, halogen, alkyl, haloalkyl, hydroxy, alkoxy, cycloalkoxy, aryloxy, alkoxyalkyl, alkoxyalkoxy, cycloalkyl, halocycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclyl, alkenyl, alkylcarbonyl, cycloalkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, Alkoxycarbonyl, Hydroxycarbonyl, Cycloalkoxycarbonyl, Cycloalkylalkoxycarbonyl, Alkoxycarbonylalkyl, Arylalkoxycarbonyl, Arylalkoxycarbonylalkyl, Alkynyl, Alkynylalkyl, Alkylalkynyl, Tris-alkylsilylalkynyl, Nitro, Amino, Cyano, Haloalkoxy, Haloalkylthio, Alkylthio, Hydrothio, Hydroxyalkyl, Oxo, Heteroarylalkoxy, Arylalkoxy, Heterocyclylalkoxy, Heterocyclylalkylthio, Heterocyclyloxy, heterocyclylthio, heteroaryloxy, bis-alkylamino, alkylamino, cycloalkylamino, hydroxycarbonylalkylamino, alkoxycarbonylalkylamino, arylalkoxycarbonylalkylamino, alkoxycarbonylalkyl(alkyl)amino, aminocarbonyl, alkylaminocarbonyl, bis-alkylaminocarbonyl, cycloalkylaminocarbonyl, hydroxyca carbonylalkylaminocarbonyl, alkoxycarbonylalkylaminocarbonyl, arylalkoxycarbonylalkylaminocarbonyl. If a basic body is substituted “by one or more residues” from a list of residues (= group) or a generically defined group of residues, this includes the simultaneous substitution by several identical and/or structurally different residues. If it is a partially or fully saturated nitrogen heterocycle, it can be linked to the rest of the molecule both via carbon and via the nitrogen. Suitable substituents for a substituted heterocyclic radical are the substituents mentioned below, as well as oxo and thioxo. The oxo group as a substituent on a ring C atom then means, for example, a carbonyl group in the heterocyclic ring. This preferably also includes lactones and lactams. The oxo group can also occur on the hetero ring atoms, which can exist in different oxidation states, e.g. with N and S, and then form, for example, the divalent groups N(O), S(O) (also short SO) and S(O)2 (also short SO2) in the heterocyclic ring. In the case of -N(O)- and -S(O)- groups both enantiomers are included. According to the invention, the term “heteroaryl” stands for heteroaromatic compounds, i. H. completely unsaturated aromatic heterocyclic compounds, preferably 5- to 7-membered rings having 1 to 4, preferably 1 or 2, identical or different heteroatoms, preferably O, S or N. Examples of heteroaryls according to the invention are 1H-pyrrol-1-yl; 1H-pyrrol-2-yl; 1H-pyrrol-3-yl; furan-2-yl; furan-3-yl; thien-2-yl; thien-3-yl, 1H-imidazol-1-yl; 1H-imidazol-2-yl; 1H-imidazol-4-yl; 1H-imidazol-5-yl; 1H-pyrazol-1-yl; 1H-pyrazol-3-yl; 1H-pyrazol-4-yl; 1H-pyrazol-5-yl, 1H-1,2,3-triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4- triazol-3-yl, 4H-1,2,4-triazol-4-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,3,4- oxadiazol-2-yl, 1,2,3-oxadiazol-4-yl, 1,2,3-oxadiazol-5-yl, 1,2,5-oxadiazol-3-yl, azepinyl, pyridin-2-yl, Pyridin-3-yl, Pyridin-4-yl, Pyrazin-2-yl, Pyrazin-3-yl, Pyrimidin-2-yl, Pyrimidin-4-yl, Pyrimidin-5-yl, Pyridazin-3-yl, Pyridazin- 4-yl, 1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl, 1,2,4-triazin-5-yl, 1,2,4-triazin-6- yl, 1,2,3-triazin-4-yl, 1,2,3-triazin-5-yl, 1,2,4-, 1,3,2-, 1,3,6- and 1,2 ,6-oxazinyl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5 -yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, 1,3-thiazol-2-yl, 1,3-thiazol-4-yl, 1,3-thiazol-5-yl , oxepinyl, thiepinyl, 1,2,4-triazolonyl and 1,2,4-diazepinyl, 2H-1,2,3,4-tetrazol-5-yl, 1H-1,2,3,4-tetrazol-5 -yl, 1,2,3,4-oxatriazol-5-yl, 1 ,2,3,4-thiatriazol-5-yl, 1,2,3,5-oxatriazol-4-yl, 1,2,3,5-thiatriazol-4-yl. The heteroaryl groups according to the invention can also be substituted with one or more identical or different radicals. If two adjacent carbon atoms are part of another aromatic ring, these are fused heteroaromatic systems, such as benzo-fused or multiply fused heteroaromatics. Preferred are, for example, quinolines (e.g. quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, quinolin-5-yl, quinolin-6-yl, quinolin-7-yl, quinolin-8-yl ); isoquinolines (e.g. isoquinolin-1-yl, isoquinolin-3-yl, isoquinolin-4-yl, isoquinolin-5-yl, isoquinolin-6-yl, isoquinolin-7-yl, isoquinolin-8-yl); quinoxaline; quinazoline; cinnoline; 1,5-naphthyridine; 1,6-naphthyridine; 1,7-naphthyridine; 1,8-naphthyridine; 2,6-naphthyridine; 2,7-naphthyridine; phthalazine; pyridopyrazines; pyridopyrimidines; pyridopyridazines; pteridines; pyrimidopyrimidines. Examples of heteroaryl are also 5- or 6-membered benzo-fused rings from the group 1H-indol-1-yl, 1H-indol-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H- Indol-5-yl, 1H-indol-6-yl, 1H-indol-7-yl, 1-benzofuran-2-yl, 1-benzofuran-3-yl, 1-benzofuran-4-yl, 1-benzofuran- 5-yl, 1-benzofuran-6-yl, 1-benzofuran-7-yl, 1-benzothiophen-2-yl, 1-benzothiophen-3-yl, 1-benzothiophen-4-yl, 1-benzothiophen-5- yl, 1-benzothiophen-6-yl, 1-benzothiophen-7-yl, 1H-indazol-1-yl, 1H-indazol-3-yl, 1H-indazol-4-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 1H-indazol-7-yl, 2H-indazol-2-yl, 2H-indazol-3-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H- Indazol-6-yl, 2H-Indazol-7-yl, 2H-Isoindol-2-yl, 2H-Isoindol-1-yl, 2H-Isoindol-3-yl, 2H-Isoindol-4-yl, 2H-Isoindol- 5-yl, 2H -isoindol-6-yl; 2H-Isoindol-7-yl, 1H-Benzimidazol-1-yl, 1H-Benzimidazol-2-yl, 1H-Benzimidazol-4-yl, 1H- Benzimidazol-5-yl, 1H-Benzimidazol-6-yl, 1H-Benzimidazol-7-yl, 1,3-Benzoxazol-2-yl, 1,3-Benzoxazol-4-yl, 1,3-Benzoxazol-5- yl, 1,3-Benzoxazol-6-yl, 1,3-Benzoxazol-7-yl, 1,3-Benzthiazol-2-yl, 1,3-Benzthiazol-4-yl, 1,3-Benzthiazol-5- yl, 1,3-Benzthiazol-6-yl, 1,3-Benzthiazol-7-yl, 1,2-Benzisoxazol-3-yl, 1,2-Benzisoxazol-4-yl, 1,2-Benzisoxazol-5- yl, 1,2-Benzisoxazol-6-yl, 1,2-Benzisoxazol-7-yl, 1,2-Benzisothiazol-3-yl, 1,2-Benzisothiazol-4-yl, 1,2-Benzisothiazol-5- yl, 1,2-benzisothiazol-6-yl, 1,2-benzisothiazol-7-yl. The term "halogen" means, for example, fluorine, chlorine, bromine or iodine. When the term is used for a radical, "halo" means, for example, fluoro, chloro, bromo or iodo. According to the invention, “alkyl” means a straight-chain or branched, open-chain, saturated hydrocarbon radical which is optionally mono- or polysubstituted and, in the latter case, is referred to as “substituted alkyl”. Preferred substituents are halogen atoms, alkoxy, haloalkoxy, cyano, alkylthio, haloalkylthio, amino or nitro groups, particularly preferred are methoxy, methyl, fluoroalkyl, cyano, nitro, fluorine, chlorine, bromine or iodine. The prefix "bis" also includes the combination of different alkyl radicals, e.g. methyl(ethyl) or ethyl(methyl). "Haloalkyl", "-alkenyl" and "alkynyl" mean alkyl, alkenyl or alkynyl, e.g. B. CH2CH2Cl, CH2CH2Br, CHClCH3, CH2Cl, CH2F; perhaloalkyl such as e.g. B. CCl3, CClF2, CFCl2, CF2CClF2, CF2CClFCF3; polyhaloalkyl such as e.g. e.g., CH2CHFCl, CF2CClFH, CF2CBrFH, CH2CF3; The term perhaloalkyl also includes the term perfluoroalkyl. "Partially fluorinated alkyl" means a straight-chain or branched, saturated hydrocarbon which is substituted one or more times by fluorine, where the corresponding fluorine atoms can be present as substituents on one or more different carbon atoms of the straight-chain or branched hydrocarbon chain, such as e.g. B.CHFCH3, CH2CH2F, CH2CH2CF3, CHF2, CH2F, CHFCF2CF3 "Partially fluorinated haloalkyl" means a straight-chain or branched, saturated hydrocarbon substituted by various halogen atoms having at least one fluorine atom, with all other optionally present halogen atoms being selected from the group fluorine, chlorine or bromine, iodine. The corresponding halogen atoms can be present as substituents on one or more different carbon atoms of the straight-chain or branched hydrocarbon chain. Partially fluorinated haloalkyl also includes complete substitution of the straight or branched chain with halogen involving at least one fluorine atom. For example, "haloalkoxy" is OCF3, OCHF2, OH2F, OCF2CF3, OH2CF3 and OCH2CH2Cl; The same applies to haloalkenyl and other radicals substituted by halogen. The expression "(C1-C4)-Alkyl" means an abbreviation for straight-chain or branched alkyl with one to 4 carbon atoms corresponding to the range specified for carbon atoms, i.e. includes the radicals methyl, ethyl, 1-propyl, 2-propyl, 1-butyl, 2-butyl, 2 -methylpropyl or tert-butyl. General alkyl radicals with a larger specified range of carbon atoms, e.g. "(C1-C6)-Alkyl" accordingly also include straight-chain or branched alkyl radicals with a larger number of carbon atoms, i.e. according to the example also the alkyl radicals with 5 and 6 carbon atoms. Unless specifically stated, the hydrocarbon radicals such as alkyl, alkenyl and alkynyl radicals, also in compound radicals, which preferably have lower carbon structures, for example with 1 to 6 carbon atoms or, in the case of unsaturated groups, with 2 to 6 carbon atoms e.g., methyl, ethyl, n- or i-propyl, n-, i-, t- or 2-butyl, pentyls, hexyls such as n-hexyl, i-hexyl and 1,3-dimethylbutyl, heptyls such as n-heptyl , 1-methylhexyl and 1,4-dimethylpentyl; alkenyl and alkynyl radicals have the meaning of the possible unsaturated radicals corresponding to the alkyl radicals, where at least one double bond or triple bond is present. Preference is given to radicals having a double bond or triple bond. The term "alkenyl “ concludes esp especial also straight-chain or branched open-chain hydrocarbon radicals with more than one double bond, such as 1,3-butadienyl and 1,4-pentadienyl, but also allenyl or cumulenyl radicals with one or more cumulative double bonds, such as allenyl (1,2 -propadienyl), 1,2-butadienyl and 1,2,3-pentatrienyl. Alkenyl means, for example, vinyl, which can optionally be substituted by further alkyl radicals, for example (but not limited to) (C2-C6)-alkenyl such as ethenyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl- 2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1- butenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-1-propenyl, 1-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1-pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl, 4-methyl-1-pentenyl, 1- Methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 1-methyl-3-pentenyl, 2-methyl-3-pentenyl, 3-methyl- 3-pentenyl, 4-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2- methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-1- butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1,3-dimethyl-1-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3- butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-1- butenyl, 3,3-dimethyl-2-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-1-butenyl, 2-ethyl-2- butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl, 1-ethyl-2-methyl-1-propenyl and 1-ethyl- 2-methyl-2-propenyl. The term "alkynyl" also includes in particular straight-chain or branched open-chain hydrocarbon radicals with more than one triple bond or with one or more triple bonds and one or more double bonds, such as 1,3-butatrienyl or 3-pentene-1-in-1 -yl. (C2-C6)-Alkynyl means, for example, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl , 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl , 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3 -pentynyl, 2-methyl-4-pentynyl, 3-methyl-1-pentynyl, 3-methyl-4-pentynyl, 4-methyl-1-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl -2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1-ethyl-2 -butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl and 1-ethyl-1-methyl-2-propynyl. The term "cycloalkyl" means a carbocyclic, saturated ring system preferably having 3-8 ring C atoms, e.g. cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, which is optionally further substituted, preferably by hydrogen, alkyl, alkoxy, cyano, nitro, alkylthio , haloalkylthio, halogen, alkenyl, alkynyl, haloalkyl, amino, alkylamino, bisalkylamino, alcocycarbonyl, hydroxycarbonyl, arylalkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl. In the case of optionally substituted cycloalkyl, cyclic systems with substituents are included, with substituents having a double bond on the cycloalkyl radical, e.g. an alkylidene group such as methylidene. In the case of optionally substituted cycloalkyl, polycyclic aliphatic systems are also included, such as bicyclo[1.1.0]butan-1-yl, bicyclo[1.1.0]butan-2-yl, bicyclo[2.1.0]pentan-1-yl , bicyclo[1.1.1]pentan-1-yl, bicyclo[2.1.0]pentan-2-yl, bicyclo[2.1.0]pentan-5-yl, bicyclo[2.1.1]hexyl, bicyclo[2.2.1 ]hept-2-yl, bicyclo[2.2.2]octan-2-yl, bicyclo[3.2.1]octan-2-yl, bicyclo[3.2.2]nonan-2-yl, adamantan-1-yl and adamantane -2-yl, but also systems such. B. 1,1'-Bi(cyclopropyl)-1-yl, 1,1'-Bi(cyclopropyl)-2-yl. The expression "(C3-C7)-Cycloalkyl" means an abbreviation for cycloalkyl with three to 7 carbon atoms corresponding to the range for C atoms. In the case of substituted cycloalkyl, spirocyclic aliphatic systems are also included, such as spiro[2.2]pent-1-yl, spiro[2.3]hex-1-yl, spiro[2.3]hex-4-yl, 3-spiro[2.3] hex-5-yl, spiro[3.3]hept-1-yl, spiro[3.3]hept-2-yl. "Cycloalkenyl" means a carbocyclic, non-aromatic, partially unsaturated ring system preferably having 4-8 carbon atoms, e.g. 1-cyclobutenyl, 2-cyclobutenyl, 1-cyclopentenyl, 2-cyclopentenyl, 3-cyclopentenyl, or 1-cyclohexenyl, 2- Cyclohexenyl, 3-cyclohexenyl, 1,3-cyclohexadienyl or 1,4-cyclohexadienyl, with substituents having a double bond on the cycloalkenyl radical, e.g. an alkylidene group such as methylidene. In the case of optionally substituted cycloalkenyl, the explanations for substituted cycloalkyl apply accordingly. The term "alkylidene", e.g. B. also in the form (C1-C10)-Alkylidene means the radical of a straight-chain or branched open-chain hydrocarbon radical which is bonded via a double bond. Of course, only positions on the skeleton where two H atoms can be replaced by the double bond can be considered as binding sites for alkylidene; leftovers are e.g. e.g. =CH2, =CH-CH3, =C(CH3)-CH3, =C(CH3)-C2H5 or =C(C2H5)-C2H5 Cycloalkylidene means a carbocyclic radical bonded via a double bond. "Cycloalkylalkyloxy" means an oxygen-bonded cycloalkylalkyl radical and "arylalkyloxy" means an oxygen-bonded arylalkyl radical. "Alkoxyalkyl" means an alkoxy radical bonded through an alkyl group and "alkoxyalkoxy" means an alkoxyalkyl radical bonded through an oxygen atom, such as (but not limited to) methoxymethoxy, methoxyethoxy, ethoxyethoxy, methoxy-n-propyloxy. “Alkylthioalkyl” means an alkylthio radical bonded through an alkyl group and “alkylthioalkylthio” means an alkylthioalkyl radical bonded through an oxygen atom. “Arylalkoxyalkyl” means an aryloxy radical bonded through an alkyl group and “heteroaryloxyalkyl” means a heteroaryloxy radical bonded through an alkyl group. "Haloalkoxyalkyl" means a linked haloalkoxy radical and "haloalkylthioalkyl" means a haloalkylthio radical linked through an alkyl group. “Arylalkyl” means an aryl radical bonded through an alkyl group, “heteroarylalkyl” means a heteroaryl radical bonded through an alkyl group, and “heterocyclylalkyl” means a heterocyclyl radical bonded through an alkyl group. "Cycloalkylalkyl" represents a cycloalkyl radical bonded via an alkyl group, e.g. B. (but not limited to) cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, 1-cyclopropyleth-1-yl, 2-cyclopropyleth-1-yl, 1-cyclopropylprop-1-yl, 3-cyclopropylprop-1-yl. "Arylalkenyl" means an aryl radical bonded through an alkenyl group, "heteroarylalkenyl" means a heteroaryl radical bonded through an alkenyl group, and "heterocyclylalkenyl" means a heterocyclyl radical bonded through an alkenyl group. "Arylalkynyl" means an aryl radical bonded through an alkynyl group, "heteroarylalkynyl" means a heteroaryl radical bonded through an alkynyl group, and "heterocyclylalkynyl" means a heterocyclyl radical bonded through an alkynyl group. According to the invention, “haloalkylthio”—on its own or as part of a chemical group—is straight-chain or branched S-haloalkyl, preferably having 1 to 8 or 1 to 6 carbon atoms, such as (C1-C8th)-, (C1-C6)- or (C1-C4)-haloalkylthio such as (but not limited to) trifluoromethylthio, pentafluoroethylthio, difluoromethyl, 2,2-difluoroeth-1-ylthio, 2,2,2-difluoroeth-1-ylthio, 3,3,3-prop-1-ylthio . "Halocycloalkyl" and "halocycloalkenyl" denote identical or different halogen atoms, such as e.g. B. F, Cl and Br, or by haloalkyl, such as. B. trifluoromethyl or difluoromethyl partially or fully substituted cycloalkyl or cycloalkenyl, e.g. 1-fluorocycloprop-1-yl, 2-fluorocycloprop-1-yl, 2,2-difluorocycloprop-1-yl, 1-fluorocyclobut-1-yl, 1- Trifluoromethylcycloprop-1-yl, 2-trifluoromethylcycloprop-1-yl, 1-chlorocycloprop-1-yl, 2-chlorocycloprop-1-yl, 2,2-dichlorocycloprop-1-yl, 3,3-difluorocyclobutyl, according to the invention "Trialkylsilyl" - alone or as part of a chemical group - for straight-chain or branched Si-alkyl, preferably with 1 to 8, or with 1 to 6 carbon atoms, such as tri-[(C1-C8th)-, (C1-C6)- or (C1-C4)-alkyl]silyl, such as (but not limited to) trimethylsilyl, triethylsilyl, tri-(n-propyl)silyl, tri-(iso-propyl)silyl, tri-(n-butyl)silyl, tri-(1-methylprop -1-yl)silyl, tri(2-methylprop-1-yl)silyl, tri(1,1-dimethyleth-1-yl)silyl, tri(2,2-dimethyleth-1-yl)silyl. "Trialkylsilylalkynyl" represents a trialkylsilyl radical bonded through an alkynyl group. If the compounds can form tautomers by hydrogen shift which would not be formally covered by formula (I) structurally, then these tautomers are nevertheless within the definition of the compounds of the formula (I) according to the invention, unless a specific tautomer is the subject of consideration. For example, many carbonyl compounds can exist in both the keto form and the enol form, both forms being encompassed by the definition of the compound of formula (I). Depending on the type and linkage of the substituents, the compounds of the general formula (I) can be present as stereoisomers. The possible stereoisomers defined by their specific spatial form, such as enantiomers, diastereomers, Z and E isomers are all encompassed by the formula (I). If, for example, one or more alkenyl groups are present, diastereomers (Z and E isomers) can occur. For example, if one or more asymmetric carbon atoms are present, enantiomers and diastereomers can occur. Stereoisomers can be obtained from the mixtures obtained in the preparation by customary separation methods. The chromatographic separation can be carried out both on an analytical scale to determine the enantiomeric excess or diastereomeric excess and on a preparative scale to produce test specimens for biological testing. Likewise, stereoisomers can be prepared selectively by using stereoselective reactions using optically active starting materials and/or auxiliaries. The invention thus also relates to all stereoisomers which are covered by the general formula (I) but are not specified with their specific stereo form, and mixtures thereof. If the compounds are obtained as solids, they can also be purified by recrystallization or digestion. If individual compounds (I) are not satisfactorily accessible by the routes described below, they can be prepared by derivatizing other compounds (I). Suitable methods for isolating, purifying and separating stereoisomers of compounds of the formula (I) are methods which are generally known to the person skilled in the art from analogous cases, e.g. by physical methods such as crystallization, chromatographic methods, especially column chromatography and HPLC (high pressure liquid chromatography), distillation, optionally under reduced pressure, extraction and other methods, any remaining mixtures can usually be separated by chromatographic separation, e.g. on chiral solid phases. For preparative amounts or on an industrial scale, processes such as crystallization, e.g. Synthesis The compounds of the general formula (I) according to the invention can be prepared via various synthesis routes described in the literature, starting from starting substances that are commercially available or easily prepared. The substituted pyrrolidinones of the general formula (I.1) can be prepared using a synthesis described in the literature (J. Org. Chem.1950, 2727) by reacting a suitable, optionally further substituted trans-hexenedioic acid with a suitable, optionally further substituted amine, preferably one benzyl- or heteroarylmethylamine, can be prepared at elevated temperature in a suitable polar-protic solvent (e.g. water or acetic acid) (scheme 1). The ring closure reaction was carried out in a suitable closed vessel under microwave conditions. In Synthesis Scheme 1 below, the groups R1, R3, R4, R5, R6, R13, R14, R15, R35, R36 of general formula (I.1) have the definitions described above, while R7 represents hydrogen by way of example but not limitation. I
Figure imgf000098_0001
Scheme 1. The pyrrolidinone (I.1a) resulting from the ring-closure reaction can then be 5.2λ5,4λ5,6λ5-trioxatriphosphinan-2,4,6-trioxide (T3P), hydroxybenzotriazole (HOBt)] using a suitable base (e.g. triethylamine or diisopropylethylamine) in a suitable polar-aprotic solvent (e.g. dichloromethane) into the corresponding esters (I.1b) or amides (I.1c) are converted. Alternatively, oxopyrrolidinyl esters (I.1d) using a two-stage Chain extension from the corresponding oxopyrrolidinyl carboxylates (C) are prepared. The carboxylic acid ester (C) in question is first converted into the intermediate alcohol (D) using a suitable reducing agent (e.g. sodium or lithium borohydride), which is then converted to the desired target product (I.1d ) (Chemistry - A European Journal (2017), 23, 7428-7432I). In Scheme 2 below, the radicals R13 and R14 represented by hydrogen by way of example but not limitation, while R1, R3, R4, R5, R6 and R36 have the meanings described above.
Figure imgf000099_0001
Scheme 2. The substituted pyrrolidinones of the general formulas (I.3), (I.4) and (I.5) can also be prepared via synthesis routes described in the literature (cf. WO2012098132). By reacting a suitable, optionally further substituted itaconic acid (E) with a suitable, optionally further substituted amine, preferably an alkyl, cycloalkyl, aryl or heteroarylmethylamine, at elevated temperature (e.g. 150° C.), the corresponding 5-oxopyrrolidinyl-3 -carboxylic acid (F) obtained (scheme 3). The ring-closure reaction can be carried out in a conventional synthesis apparatus with a heating bath or in a suitable sealed vessel under microwave conditions. The intermediate carboxylic acid (E) resulting from the ring-closure reaction can then be synthesized using suitable coupling reagents [e.g. 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), 2,4,6-tripropyl-1,3,5,2λ5,4λ5,6λ5-trioxatriphosphinan-2,4,6-trioxide (T3P), hydroxybenzotriazole (HOBt)] using a suitable base (e.g. triethylamine or diisopropylethylamine) together with the corresponding optionally further substituted amine in a suitable polar-aprotic solvent (e.g. dichloromethane) in the corresponding amides (I.2) are converted. Furthermore, the carboxylic acid (E) can be synthesized by suitable reagents [e.g. diphenylphosphoryl azide (DPPA), triethylamine and tert. Butanol]-mediated degradation reaction carried out at elevated temperature (e.g. 80 °C) can be converted into the corresponding protected amine (F). Removal of the relevant protecting group [here by way of example but not limitation a tert-butyloxycarbonyl (Boc) protecting group] using a suitable reagent (e.g. by way of example but not limitation hydrochloric acid in ethyl acetate to remove the Boc group) affords the corresponding amine (G ) (optionally also as a salt, e.g. by way of example but not limitation as the HCl salt). The amine (G) can with the help of suitable coupling partners (example, but not limiting with an optionally further substituted acetic acid chloride, an optionally further substituted isocyanate or an optionally further substituted isothiocyanate) using a suitable base (e.g. triethylamine or diisopropylethylamine) in a suitable polar-aprotic solvent (e.g. dichloromethane, acetonitrile) into the corresponding optionally further substituted acetamides according to the invention (I.3), ureas (I.4) and thioureas (I.5) (cf. WO2004026825, US20110189167, WO2009138438). In Scheme 3 below, the groups R1, R3, R5, R6, R11, R12, R20, R21, R22, R37 of general formulas (I.2), (I.3), (I.4) and (I.5) have the definitions described above, while R2, R4, R8th, R9 and R10 represent hydrogen by way of example but not limitation.
Figure imgf000100_0001
Scheme 3. Alternatively, the optionally further substituted intermediate (G) can also be prepared starting from a further substituted glycine ester (H) in a multi-stage reaction via acylation, subsequent cyclization using a suitable base (e.g. sodium hydride) in a suitable polar aprotic solvent (e.g. tetrahydrofuran), oxime formation using hydroxylamine hydrochloride and a suitable base in a suitable polar aprotic solvent (e.g. dichloromethane) and final reduction of the oxime using a suitable reducing agent (e.g. sodium cyanoborohydride and hydrogen over palladium on carbon) (Scheme 4) . In Scheme 4 below, the groups R1, R3, R5, R11, R12, R37 those described above definitions, while R2, R4, R6, R8th, R9 and R10 represent hydrogen by way of example but not limitation. i
Figure imgf000101_0001
Scheme 4. Alternatively, the optionally further substituted ureas of the general formula (I.4) can be prepared starting from a substituted amino acid (J) provided with suitable protective groups (cf. WO2006063113). The base-mediated reaction of the amino acid (J) with a suitable isocyanate to form an optionally further substituted intermediate (K) takes place first. The intermediate, optionally further substituted carboxylic acid (K) obtained in this way can then be 2λ5,4λ5,6λ5-trioxatriphosphinan-2,4,6-trioxide (T3P), hydroxybenzotriazole (HOBt)] using a suitable base (e.g. triethylamine or diisopropylethylamine) together with the appropriate amine R1-NH2 in a suitable polar-aprotic solvent (e.g. dichloromethane) into the corresponding, optionally further substituted intermediate (L), which after removal of the protective group of the further acid function (by way of example, but not restrictively, with hydrogen via palladium on carbon in a suitable polar-protic solvents such as methanol to eliminate a benzyl protecting group) is cyclized using a suitable base. The final cyclization gives inventive, optionally further substituted compounds of the general formula (I.4) (scheme 5). In Synthetic Scheme 4 below, the groups R1, R5, R37 the definitions described above, while R2, R3, R4, R6, R8th and R9 represent hydrogen by way of example but not limitation.
Figure imgf000102_0001
Scheme 5. The compounds of type I.2 could also be prepared analogously to the instructions from patent application WO2011/35332 (Scheme 6). Here, as shown in Scheme 6, the corresponding pyrrolidonecarboxylic acids (O) are prepared by condensation of the corresponding anilines with itaconic acid derivatives (M). After esterification of the acids (O), e.g. using orthoesters or other methods, the corresponding carboxylic acid esters (P) are obtained. After deprotonation with a strong base such as e.g with an alkylating agent such as an alkyl halide such as methyl iodide or dimethyl sulfate to give the alkylated pyrrolidone carboxylic acid esters (Q). After saponification to the corresponding acids with inorganic bases such as sodium hydroxide or lithium hydroxide in a suitable solvent such as water, ethanol or THF, the free carboxylic acid or its salt (R) is obtained, which can then be reacted under standard conditions with a coupling reagent such as T3P, carbonyldiimidazole, HATU and others suitable methods to the amides (I.2) are implemented. H
Figure imgf000103_0002
Scheme 6. Scheme 7 outlines the synthesis of some non-commercial amines. Starting from the pyrimidone (S), oximation, subsequent chlorination, reduction, introduction of the Boc protective group and nucleophilic substitution with a large number of O-, S- and N-nucleophiles can be used to convert it into the corresponding pyrimidinemethylamines (T).
Figure imgf000103_0001
Nu- = Cl, O-, S- and N-nucleophiles Scheme 7. Selected detailed synthesis examples for the compounds of the general formula (I) according to the invention are listed below. The example numbers given correspond to the numbering given in Tables I.1 to I.5 below. the1H NMR,13C NMR and19F NMR spectroscopic data presented for the chemical examples described in the following sections (400 MHz at1H NMR and 150 MHz at13C NMR and 375 MHz at19F NMR, solvent CDCl3, cd3OD or d6-DMSO, internal standard: tetramethylsilane δ = 0.00 ppm) were obtained using a Bruker device, and the indicated signals have the following meanings: br = broad(es); s = singlet, d = doublet, t = triplet, dd = double doublet, ddd = doublet of a double doublet, m = multiplet, q = quartet, quint = quintet, sext = sextet, sept = septet, dq = double quartet, dt = double triplet. In the case of mixtures of diastereomers, either the significant signals of both diastereomers or the characteristic signal of the main diastereomer are given. The abbreviations used for chemical groups have, for example, the following meanings: Me=CH3, Et = CH2CH3, t-Hex = C(CH3)2CH(CH3)2, t-Bu = C(CH3)3, n-Bu = unbranched butyl, n-Pr = unbranched propyl, i-Pr = branched propyl, c-Pr = cyclopropyl, c-Hex = cyclohexyl. Selected synthesis examples: I.1-001: 2-[1-[(3-Chloro-2-fluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid
Figure imgf000104_0001
3-Chloro-2-fluorobenzylamine (221 mg, 1.39 mmol, 1.0 eq.) and trans-3-hexenedioic acid (200 mg, 1.39 mmol, 1.0 eq.) were suspended in water (5.0 mL) and transferred to a microwave vessel containing was then tightly closed. The reaction mixture was heated at 190°C for 1 hour under microwave conditions. The internal pressure rose to about 18 bar. After cooling to room temperature, the reaction mixture was concentrated and purified by preparative HPLC. In this way, racemic 2-[1-[(3-chloro-2-fluorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]acetic acid I.1-001 (135 mg, 34% of theory) in the form obtained a colorless oil.1H NMR (400.0 MHz, CDCl3) δ ppm 7.36-7.32 (m, 1H), 7.22-7.18 (m, 1H), 7.09-7.04 (m, 1H), 4.91-4.87 (d, 1H), 4.27-4.23 (d, 1H), 3.94-3.88 (m, 1H), 2.78-2.73 (dd, 1H), 2.62-2.42 (m, 3H), 2.37-2.26 (m, 1H), 1.93-1.85 (m, 1H) . No. I.1-604 and No. I.1-605: (+)- and (-)-2-[1-[(3-Chloro-2-fluorophenyl)methyl]-5-oxo-pyrrolidine-2 - yl]acetic acid:
Figure imgf000105_0001
The above reaction was repeated using the same amount of reagents and a combined amount of 2-[1-[(3-chloro-2-fluorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]acetic acid (I. 1-001, 200 mg) was separated into the enantiomers Ent-1 I.1- 604 (85 mg, retention time 1.177, rotation value 28.50° - 20mg/ 10mL),1H NMR (400.0 MHz, CDCl3) δ ppm 7.38-7.33 (m, 1H), 7.22-7.17 (m, 1H), 7.09-7.03 (m, 1H), 4.92-4.88 (d, 1H), 4.27-4.23 (d, 1H), 3.94-3.88 (m, 1H), 2.78-2.73 (dd, 1H), 2.62-2.42 (m, 3H), 2.39-2.25 (m, 1H), 1.93-1.85 (m, 1H) and Ent-2 I.1-605 (91 mg, retention time 1.862, rotation -36.00° - 22 mg/100 mL) separately,1H NMR (400.0 MHz, CDCl3) δ ppm 7.36-7.31 (m, 1H), 7.23-7.15 (m, 1H), 7.09-7.04 (m, 1H), 4.91-4.85 (d, 1H), 4.27-4.23 (d, 1H), 3.93-3.87 (m, 1H), 2.77-2.72 (dd, 1H), 2.64-2.43 (m, 3H), 2.37-2.26 (m, 1H), 1.93-1.84 (m, 1H) . I.1-003 - 2-[1-[(2,3-Difluorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]acetic acid:
Figure imgf000105_0002
2,3-Difluorobenzylamine (993 mg, 6.93 mmol, 1.0 eq.) and trans-3-hexenedioic acid (1.00 g, 6.93 mmol, 1.0 eq.) were suspended in water (10.0 mL) and transferred to a microwave vessel, which was then sealed would. The reaction mixture was heated at 190°C for 1 hour under microwave conditions. The internal pressure rose to about 18 bar. After cooling to room temperature, the reaction mixture was concentrated and purified by preparative HPLC. There was thus obtained 2-[1-[(2,3-difluorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]acetic acid (182.0 mg, 23% of theory) as a colorless oil.1H NMR (600.0 MHz, d6-DMSO): δ= 1.69 - 1.76 (m, 1 H), 2.14 - 2.29 (m, 2 H), 2.34 - 2.45 (m, 2 H), 2.69 (dd, J= 15.97, 4.05 Hz, 1 H), 3.76 (tt, J=8.31, 4.14 Hz, 1 H), 4.24 (d, J=15.85 Hz, 1 H), 4.73 (d, J=15.85 Hz, 1 H), 7.08 (t, J=7.03 Hz, 1 H), 7.16 - 7.21 (m, 1 H), 7.36 (q, J=8.42 Hz, 1 H). I.1-036: 2-(4-Methylphenoxy)ethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetate
Figure imgf000106_0001
2-( 4-Methylphenoxy)ethanol (170.0 mg, 1.11 mmol, 2.0 eq.), DMAP (0.7 mg, 0.05 mmol, 0.1 eq.) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (117.0 mg, 0.61 mmol, 1.1 eq.) added. The reaction mixture was stirred at room temperature for 5 hours. Then water (20 mL) was added and the aqueous phase was thoroughly extracted with dichloromethane (3 x 50 mL). The combined organic phases were dried over magnesium sulfate, filtered and concentrated under reduced pressure. By column chromatographic purification of the remaining residue [silica gel; heptane/EtOAc (4:1)] became 2-(4-methylphenoxy)ethyl 2-[1-[(2,3-difluorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]acetate I.1-036 (141.0 mg, 62% of theory) in the form of a colorless oil.1H NMR(400.1 MHz, CDCl3): δ ppm 1.79 - 1.89 (m, 1 H), 2.22 - 2.31 (m, 4 H), 2.34 - 2.52 (m, 3 H), 2.75 (dd, J=15.57, 3.99 Hz, 1 H), 3.88 (dt, J=8.31, 4.16 Hz, 1 H), 4.09 - 4.15 (m, 2 H), 4.24 (d, J=15.49 Hz, 1 H), 4.37 - 4.44 (m , 2 H), 4.86 (dd, J=15.57, 1.55 Hz, 1 H), 6.75 - 6.82 (m, 2 H), 7.00 - 7.12 (m, 5 H). I.1-056: 2-[1-[(2,3-difluorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(4-methyl-1,2,5-oxadiazole-3- yl)acetamide
Figure imgf000106_0002
2-[1-[(2,3-difluorophenyl) methyl]-5-oxopyrrolidin-2-yl]acetic acid (200.0 mg, 0.74 mmol, 1.0 eq.) and 2,4,6-tripropyl-1,3,5,2λ5,4λ5,6λ5-trioxatriphosphinan-2,4,6-trioxide (709.0 mg, 0.663 mL, 1.11 mmol, 1.5 eq., 50% solution in EtOAc). The reaction mixture was stirred at room temperature for 1 hour. This was followed by the dropwise addition of triethylamine (376.0 mg, 0.52 mL, 3.71 mmol, 5.0 eq.) and the addition of DMAP (18.0 mg, 0.14 mmol.0.2 eq.), and the resulting reaction mixture was stirred at room temperature for 16 h. Then water (20 mL) was added and the aqueous phase was thoroughly extracted with dichloromethane (3 x 50 mL). The combined organic phases were dried over magnesium sulfate, filtered and concentrated under reduced pressure. By preparative HPLC purification of the remaining The residue was 2-[1-[(2,3-difluorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(4-methyl-1,2,5-oxadiazol-3-yl)acetamide I .1-056 (114.0 mg, 43% of theory) in the form of a yellowish oil.1H-NMR(400.1MHz, i.e6-DMSO): δppm 1.77 - 1.87 (m, 1H), 2.18 - 2.37 (m, 5H), 2.37 - 2.44 (m, 1H), 2.54 - 2.62 (m, 1H), 2.88 (dd, J=14.92, 4.16 Hz, 1 H), 3.90 (br d, J=3.91 Hz, 1 H), 4.28 (d, J=15.98 Hz, 1 H), 4.73 (d, J=16.14 Hz, 1 H) , 7.05 - 7.11 (m, 1 h), 7.15 - 7.22 (m, 1 h), 7.30 - 7.39 (m, 1 h). I.1-133: 2-[1-[(2,3-dichlorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]acetic acid
Figure imgf000107_0001
2,3-Dichlorobenzylamine (1.21 g, 6.93 mmol, 1.0 eq.) and trans-3-hexenedioic acid (1.00 g, 6.93 mmol, 1.0 eq.) were suspended in water (10.0 mL) and transferred to a microwave vessel, which was then sealed would. The reaction mixture was heated at 190°C for 1 hour under microwave conditions. The internal pressure rose to about 18 bar. After cooling to room temperature, the reaction mixture was concentrated and purified by preparative HPLC. There was thus obtained 2-[1-[(2,3-dichlorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]acetic acid I.1-133 (847.0 mg, 40% of theory) as a colorless solid .1H NMR (400.1 MHz, d6-DMSO): δ ppm 1.72 - 1.82 (m, 1 H), 2.19 - 2.34 (m, 2 H), 2.36 - 2.45 (m, 2 H), 2.65 (dd, J= 16.06, 4.32 Hz, 1 H), 3.81 (tt, J=8.09, 4.22 Hz, 2 H), 4.29 (d, J=16.47 Hz, 1 H), 4.68 (d, J=16.47 Hz, 1 H), 7.22 (dd, J=7.66, 1.47 Hz, 1 H), 7.35 (t, J=7.91 Hz, 1 H), 7.57 (dd, J=7.99, 1.47 Hz, 1 H). I.1-311: 2-[1-[(2,3-Dichlorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamide
Figure imgf000107_0002
To a solution of 2-[1-[(2,3-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]acetic acid (250.0 mg, 0.82 mmol, 1.0 eq.) in abs. Dichloromethane (30 mL) were N,N-dimethylsulfamide (205.0 mg, 1.65 mmol, 2.0 eq.), DMAP (0.1 mg, 0.08 mmol, 0.1 eq.) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (174.0 mg, 0.91 mmol, 1.1 eq.). The resulting reaction mixture was stirred at room temperature for 16 h. Then water (20 mL) was added and the aqueous phase was thoroughly extracted with dichloromethane (3 x 50 mL). The combined organic phases were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Preparative HPLC purification of the remaining residue gave 2-[1-[(2,3-dichlorophenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamide I.1-311 (151.0 mg , 44% of theory) as colorless Obtain solid.1H NMR (400 MHz, i.e6-DMSO) δ ppm 1.75 - 1.83 (m, 1 H), 2.18 - 2.46 (m, 4 H), 2.66 - 2.73 (m, 1 H), 3.85 (tt, J=8.15, 4.08 Hz, 1 H), 4.27 (d, J=16.63 Hz, 1H), 4.66 (d, J=16.63 Hz, 1H), 7.17 - 7.21 (m, 1H), 7.36 (t, J=15.81 Hz, 1H), 7.56 - 7.60 (m, 1h). I.1-599: [5-Oxo-1-(2,3,6-trifluorobenzyl)pyrrolidin-2-yl]acetic acid.
Figure imgf000108_0001
Trans-3-hexenedioic acid (300 mg, 2.08 mmol) and 1-(2,3,6-trifluorophenyl)methylamine (335 mg, 2.08 mmol) were placed in a microwave vial together with water (5 mL) and heated at at for 1 h implemented at a temperature of 190 °C. The pressure rose to 18 bar. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. Preparative HPLC purification gave [5-oxo-1-(2,3,6-trifluorobenzyl)pyrrolidin-2-yl]acetic acid as a colorless solid (144 mg, 25% of theory),1H NMR (400 MHz, CDCl3) δ ppm 7.18-7.10 (m, 1H), 6.90-6.84 (m, 1H), 5.19 (d, 1H), 4.17 (d, 1H), 3.86-3.80 (m, 1H), 2.84-2.79 (dd, 1H), 2.62-2.43 (m, 3H), 2.33-2.25 (m, 1H), 1.93-1.86 (m, 1H). I.1-600: [5-Oxo-1-(2,3,4-trifluorobenzyl)pyrrolidin-2-yl]acetic acid.
Figure imgf000108_0002
Trans-3-hexenedioic acid (100 mg, 0.69 mmol) and 1-(2,3,4-trifluorophenyl)methylamine (112 mg, 0.69 mmol) were placed in a microwave vial together with water (5 mL) and heated at at for 1 h implemented at a temperature of 190 °C. The pressure rose to 18 bar. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. Preparative HPLC purification gave [5-oxo-1-(2,3,4-trifluorobenzyl)pyrrolidin-2-yl]acetic acid as a colorless solid (52 mg, 27% of theory),1H NMR (400 MHz, CDCl3) δ ppm 7.09-7.03 (m, 1H), 6.98-6.92 (m, 1H), 4.87 (d, 1H), 4.21 (d, 1H), 3.93-3.87 (m, 1H ), 2.80-2.75 (dd, 1H), 2.61-2.40 (m, 3H), 2.38-2.27 (m, 1H), 1.94-1.86 (m, 1H). I.1-601: [5-Oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin-2-yl]acetic acid.
Figure imgf000109_0002
Trans-3-hexenedioic acid (200 mg, 1.39 mmol) and 1-(2,3,5-trifluorophenyl)methylamine (224 mg, 1.39 mmol) were placed in a microwave vial together with water (5 mL) and heated at at for 1 h implemented at a temperature of 190 °C. The pressure rose to 18 bar. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. Preparative HPLC purification gave [5-oxo-1-(2,3,5-trifluorobenzyl)pyrrolidin-2-yl]acetic acid as a colorless solid (116 mg, 32% of theory),1H NMR (400 MHz, CDCl3) δ ppm 6.90-6.79 (m, 2H), 4.85 (d, 1H), 4.29 (d, 1H), 3.95-3.88 (m, 1H), 2.78-2.74 (dd, 1H), 2.61-2.42 (m, 3H), 2.39-2.30 (m, 1H), 1.94-1.86 (m, 1H). I.1-602: [5-Oxo-1-(2,3-dimethylbenzyl)pyrrolidin-2-yl]acetic acid.
Figure imgf000109_0003
Trans-3-hexenedioic acid (300 mg, 2.08 mmol) and 1-(2,3-dimethylphenyl)methylamine (281 mg, 2.08 mmol) were placed in a microwave vessel together with water (5 mL) and heated at one temperature for 1 hour implemented at 190 °C. The pressure rose to 18 bar. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. Preparative HPLC purification gave [5-oxo-1-(2,3-dimethylbenzyl)pyrrolidin-2-yl]acetic acid as a colorless solid (131 mg, 24% of theory),1H NMR (400 MHz, CDCl3) δ ppm 7.13-7.11 (d, 1H), 7.09-7.05 (dd, 1H), 6.98-6.96 (d, 1H), 5.04 (d, 1H), 4.08 (d, 1H ), 3.80-3.75 (m, 1H), 2.68-2.50 (m, 3H), 2.48-2.41 (dd, 1H), 2.31-2.23 (m, 1H), 2.28 (s, 3H), 2.15 (s, 3H ), 1.95-1.88 (m, 1H). I.1-603: 2-[1-[(2,3-Difluorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(1,2,4-thiadiazol-5-yl)acetamide
Figure imgf000109_0001
2-[1-[(2,3-Difluorophenyl)methyl]-5 -oxo-pyrrolidin-2-yl]acetic acid (235 mg, 0.87 mmol, 1.0 eq.) and cyclic 1-propylphosphonic anhydride (T3P®, 722 mg, 0.68 mL, 1.13 mmol, 1.3 eq., 50% solution in tetrahydrofuran). The reaction mixture was stirred at room temperature for 1 h and then triethylamine (0.37 mL, 2.62 mmol, 3.0 eq.) was added dropwise. The resulting reaction mixture was stirred at room temperature for a further 8 h and then treated with water (20 mL) and thoroughly extracted several times with dichloromethane (3 x 50 mL). The combined organic phases were dried over magnesium sulfate, filtered off and concentrated under reduced pressure. Purification of the resulting crude product using preparative HPLC separation gave 2-[1-[(2,3-difluorophenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(1,2,4-thiadiazole -5-yl)acetamide I.1-603 (110 mg, 35% of theory) as a colorless solid.1H NMR (400.0 MHz, CDCl3) δ ppm 11.77 (br. s, 1H, NH), 8.21 (s, 1H), 7.08-7.01 (m, 3H), 4.84-4.80 (d, 1H), 4.36-4.32 (d, 1H), 4.16-4.12 (m, 1H), 3.04-2.99 (dd, 1H), 2.72-2.66 (dd, 1H), 2.62-2.48 (m, 2H), 2.44-2.37 (m, 1H) , 1.95-1.88 (m, 1H). I.2-32: N -[(2-Chloropyridin-4-yl)methyl]-6-(3,5-dichlorophenyl)-2,4-dimethyl-7-oxo-6-azabicyclo[3.2.1]oct -3-ene-8-carboxamide
Figure imgf000110_0001
Under nitrogen, 91.0 mg (0.27 mmol) of 6-(3,5-dichlorophenyl)-2,4-dimethyl-7-oxo-6-azabicyclo[3.2.1]oct-3-en-8-carboxylic acid in 2 mL of dry Submitted dichloromethane, then successively with 36.1 mg (0.27 mmol) HOBT in 1 ml dichloromethane, 52.7 mg (0.29 mmol) 1-(2-chloropyridin-4-yl)methanamine hydrochloride, 103.7 mg (0.8 mmol) ethyldiisopropylamine and finally with 66.7 mg ( 0.35 mmol) EDCl added and stirred at room temperature for 12 h. The solution was then evaporated and purified over silica gel. After purification over silica gel, 120 mg (purity 95%, 92% of theory) of the product N-[(2-chloropyridin-4-yl)methyl]-6-(3,5-dichlorophenyl)-2,4-dimethyl- Obtained 7-oxo-6-azabicyclo[3.2.1]oct-3-ene-8-carboxamide.1H NMR (400.0 MHz, CDCl3) δ 8.2776 (2.8); 8.2761 (2.7); 8.2648 (2.9); 8.2634 (2.8); 7.5270 (11.8); 7.5225 (11.8); 7.5190 (1.6); 7.2715 (1.1); 7.2707 (1.2); 7.2601 (201.1); 7.2100 (1.0); 7.1440 (3.4); 7.1395 (8.3); 7.1349 (5.1); 7.0283 (1.9); 7.0264 (1.6); 7.0246 (1.8); 7.0155 (1.8); 7.0137 (1.5); 7.0118 (1.6); 6.9961 (1.1); 6.2238 (0.8); 5.3596 (1.8); 5.3563 (1.8); 4.5527 (2.7); 4.4646 (1.9); 4.4477 (2.8); 4.4310 (1.9); 3.0052 (4.5); 2.9545 (1.4); 2.9424 (1.6); 2.7799 (0.6); 2.7741 (0.7); 2.7679 (0.8); 2.7618 (0.8); 2.7558 (0.7); 2.7497 (0.6); 2.0905 (1.2); 1.8615 (6.3); 1.8572 (7.7); 1.8555 (7.6); 1.8513 (6.2); 1.5970 (0.6); 1.5807 (0.7); 1.5473 (16.0); 1.5242 (0.9); 1.5072 (0.7); 1.2554 (0.7); 1.2076 (9.5); 1.1894 (9.3); 0.0079 (2.4); -0.0002 (85.7); -0.0085 (2.6). I.2-33: 1-[3,5-Bis(trifluoromethyl)phenyl]-N-{[2-(ethylamino)pyrimidin-4-yl]methyl}-5-oxopyrrolidine-3-carboxamide
Figure imgf000111_0001
For this purpose, 202.0 mg (0.29 mmol) of ethane 1,2-diylbis{1-[3,5-bis(trifluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxylate} were dissolved in 6 mL of THF and 2 mL of water and first im Stirred in an ice bath with 0.3 mL 2M sodium hydroxide solution (=24 mg NaOH (0.6 mmol)). It is allowed to warm to room temperature and after 1 h it is cooled to 0°C. The solution was neutralized with 2M hydrochloric acid. The reaction mixture was then evaporated, taken up in water and brought to pH 2 with 2M hydrochloric acid. The solid was filtered off and dried in vacuo. 183.0 mg (purity 95%, 90% of theory) of the desired 1-[3,5-bis(trifluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxylic acid were obtained.1H NMR (400.0 MHz, i.e1-chloro form): δ= 2.95 - 3.09 (m, 2 H) 3.44 - 3.54 (m, 1 H) 4.12 - 4.26 (m, 2 H) 7.68 (bs, 1 H) 8.12 (bs, 2 H).10.0 g (72.0 mmol) 2-chloropyrimidine-4-carbonitrile in methanol (50 mL) were carefully added at 0 °C with 30 mL 30% ethylamine in methanol (about 200 mmol) and stirred at this temperature for 2 h. Thereafter, the reaction mixture was poured into water (50 mL). The yellow solid formed, 2-(ethylamino)pyrimidine-4-carbonitrile, was filtered off and dried without further purification. 2.8 g Pd/C (10 wt%) and 14.6 g (144.3 mmol, 20 mL) triethylamine in ethanol (200 mL) were added to this crude product and hydrogenated overnight at normal pressure and room temperature (air balloon). The reaction mixture was then filtered and the filtrate was concentrated. The residue was dissolved in EtOAc (100 mL) and stirred with 15.0 mL of 4M (60 mmol) hydrochloric acid in dioxane. The solid formed was filtered off and dried. 6.5 g (48% of theory) of 4-(aminomethyl)-N-ethylpyrimidin-2-amine hydrochloride were obtained as a brown solid. MS-ESI: [M+H]+ 152.1H NMR (500.0 MHz, i.e6-DMSO): δ= 10.08 (s, 1H), 8.71 (s, 3H), 8.40 (d, J = 4.5 Hz, 1H), 6.92 (d, J = 5.5 Hz, 1H), 4.16 (s, 2H) , 3.50 (s, 2H), 1.18-1.14(m, 3H). 61.0 mg (0.17 mmol) of 1-[3,5-bis(trifluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxylic acid in 3 mL of dry THF were initially introduced under nitrogen, then successively with 24.2 mg (0.17 mmol) of HOBT in 1 mL THF, 37.1 mg (0.19 mmol) 4-(aminomethyl)-N-ethylpyrimidin-2-amine hydrochloride, 92.4 mg (0.71 mmol) ethyldiisopropylamine and finally treated with 44.6 mg (0.23 mmol) EDCl in 6 mL THF and 12 h at room temperature touched. The solution was then spun in, taken up in 2 mL dichloromethane and purified directly on silica gel. 79.0 mg (purity 90%, 84% of theory) of the product N1-[3,5-bis(trifluoromethyl)phenyl]-N-{[2-(ethylamino)pyrimidin-4-yl]methyl}-5- were obtained. oxopyrrolidine-3-carboxamide as a colorless solid.1H NMR(400.0MHz, CDCl3): δ 8.2489 (1.7); 8.2364 (1.7); 8.1401 (6.4); 7.9001 (0.5); 7.8791 (0.6); 7.6685 (0.6); 7.6510 (2.9); 7.2621 (49.4); 7.0400 (0.9); 6.4962 (3.4); 6.4835 (3.4); 4.4364 (3.1); 4.4337 (3.2); 4.4246 (3.2); 4.4219 (3.2); 4.2766 (1.7); 4.2588 (1.8); 4.2528 (2.2); 4.2349 (2.2); 4.0945 (2.0); 4.0730 (2.6); 4.0708 (2.2); 4.0492 (1.7); 3.4862 (1.3); 3.4784 (1.4); 3.4687 (1.4); 3.4613 (1.3); 3.3801 (1.0); 3.3622 (1.0); 3.3594 (1.2); 3.3567 (1.1); 3.3388 (1.0); 3.0772 (1.6); 3.0562 (1.3); 3.0341 (3.0); 3.0131 (2.8); 2.9627 (3.0); 2.9391 (2.8); 2.9196 (1.5); 2.8960 (1.3); 2.0944 (0.8); 1.3310 (0.8); 1.2873 (7.6); 1.2832 (1.8); 1.2693 (16.0); 1.2573 (1.9); 1.2512 (7.7); 1.2395 (1.4); 1.2215 (0.6); 0.0079 (0.6); -0.0002 (17.8); -0.0085 (0.7). I.2-113: N -{[2-(Cyclobutyloxy)pyridin-4-yl]methyl}-1-(3,5-difluorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxamide
Figure imgf000112_0001
A mixture of 29.8 g (0.230 mol) 3,5-difluoroaniline and 30.0 g (0.230 mol) itaconic acid were heated together at 130 °C for 1 h. After the reaction had ended, MTBE (70 mL) was added at about 70° C. and the mixture was cooled to room temperature. 400 mL hexane were then added and the mixture was stirred for a further 12 h, the solid was filtered off, washed with hexane and dried at 40° C. under reduced pressure. 49.0 g (88% of theory) of 1-(3,5-difluorophenyl)-5-oxopyrrolidine-3-carboxylic acid were obtained as a brown solid. 49.0 g (0.203 mol) of the 1-(3,5-difluorophenyl) obtained above -5-oxopyrrolidine-3-carboxylic acid was dissolved in 220 mL of methanol and cooled to 0 °C. Then, at this temperature, it was treated with 792 mg (0.72 mL=10.0 mmol) acetyl chloride and 21.5 g (22.0 mL=0.203 mol) trimethyl orthoformate and then heated at 64° C. for 1 h. Thereafter, the reaction mixture was evaporated in vacuo and the residue was dissolved in 750 mL dichloromethane. After washing with 500 mL of saturated aqueous sodium bicarbonate solution and 300 mL of common salt solution and drying over sodium sulfate, a crude product was obtained, which was purified chromatographically over silica gel. 33.5 g (65% of theory) of methyl 1-(3,5-difluorophenyl)-5-oxopyrrolidine-3-carboxylate were obtained as a white solid. Under argon, 38.0 g (0.149 mol) of the methyl 1-(3,5-difluorophenyl)-5-oxopyrrolidine-3-carboxylate obtained above were dissolved in 300 mL dry DMF and treated at 0 °C with 10.7 g (0.268 mol) of 60 % sodium hydride and then treated with 24.71 g (0.174 mol) of methyl iodide. Stirring was then continued at 0° C. for 1 h and heated to room temperature. After 16 h, it was hydrolyzed with 500 mL saturated ammonium chloride solution and extracted twice with 500 mL MTBE each time. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo. The residue was dissolved in dichloromethane and chromatographed over silica gel. 6.0 g (15% of theory) of methyl 1-(3,5-difluorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxylate were obtained as a colorless solid. A suspension of 6.30 g (0.023 mol) of methyl 1-(3,5-difluorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxylate obtained above in 50 mL of methanol and 50 mL of water was treated with 9.8 g (0.230 mol) Added lithium hydroxide at room temperature and heated first at room temperature and then at 80 ° C for 1 h. After the reaction had ended, the mixture was cooled and the solvent evaporated in vacuo. The residue was taken up with 100 mL water and washed twice with 150 mL MTBE each time. Thereafter, the pH of the remaining aqueous phase was adjusted to 3-4 with 2N hydrochloric acid and the aqueous phase was extracted twice with 500 mL ethyl acetate each time. After the combined ethyl acetate phases had been dried, they were filtered and the solvent removed in vacuo. The solid residue was suspended in 100 mL hexane (5 h), filtered off, washed with hexane and dried in vacuo. 5.20 g (purity 98%, 87% of theory) of the desired 1-(3,5-difluorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxylic acid were obtained as a colorless solid.1H NMR (400.0 MHz, d1-chloro form): δ = 1.57 (s, 3H), 2.59 (d, J = 17.3 Hz, 1H) 3.19 (br d, J = 17.3 Hz, 1H), 3.62 (d, J = 9.9 Hz, 1H), 4.36 (d, J = 10.0 Hz, 1H), 6.58 – 6.68 (m, 1H), 7.18 – 7.25 (m, 2H). Under nitrogen, 80 mg (0.31 mmol) of 1-(3,5-difluorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxylic acid in 4 mL of dry THF were initially introduced, then successively with 42.4 mg (0.31 mmol) of HOBT in 1 mL THF, 61.5 mg (0.34 mmol) 1-[2-(cyclobutyloxy)pyridin-4-yl]methanamine, 121.5 mg (0.94 mmol) ethyldiisopropylamine and finally treated with 78.1 mg (0.40 mmol) EDCl in 5 mL THF and left for 12 h stirred at room temperature. The solution was then evaporated, the crude product was taken up in 2.5 mL dichloromethane and purified directly on silica gel. After purification over silica gel, 126.0 mg (purity 98%, 95% of theory) of N-{[2-(cyclobutyloxy)pyridin-4-yl]methyl}-1-(3,5-difluorophenyl)-3-methyl- 5-oxo-pyrrolidine-3-carboxamide obtained as a semi-solid product.1H NMR(400.0MHz, CDCl3): δ 8.0973 (12.5); 8.0960 (12.3); 8.0842 (12.7); 8.0828 (12.6); 7.5183 (4.9); 7.3089 (1.2); 7.2928 (1.5); 7.2740 (4.6); 7.2595 (874.7); 7.2537 (9.4); 7.2529 (8.3); 7.2505 (3.4); 7.2488 (2.2); 7.2481 (2.3); 7.2433 (5.3); 7.2393 (13.8); 7.2336 (11.8); 7.2281 (2.2); 7.2219 (1.8); 7.2147 (1.0); 7.2092 (1.9); 6.9955 (4.7); 6.7332 (7.8); 6.7295 (8.2); 6.7200 (7.7); 6.7164 (7.9); 6.6424 (3.0); 6.6367 (5.4); 6.6309 (2.6); 6.6205 (6.0); 6.6148 (10.7); 6.6091 (5.3); 6.5986 (3.2); 6.5929 (5.4); 6.5872 (2.7); 6.5502 (11.3); 6.5486 (14.6); 6.5467 (14.2); 5.9792 (2.9); 5.2140 (1.5); 5.1943 (5.5); 5.1770 (7.3); 5.1747 (7.4); 5.1573 (5.5); 5.1399 (1.4); 4.4931 (0.8); 4.4778 (0.9); 4.4540 (10.0); 4.4478 (10.1); 4.4395 (9.8); 4.4331 (9.5); 4.4092 (0.7); 4.3951 (0.8); 4.3314 (12.6); 4.3070 (13.5); 4.1476 (0.9); 4.1296 (2.2); 4.1118 (2.2); 4.0939 (0.6); 3.5695 (14.8); 3.5451 (13.8); 3.1458 (12.1); 3.1040 (14.0); 2.5520 (16.0); 2.5102 (13.9); 2.4891 (2.7); 2.4823 (3.8); 2.4753 (2.9); 2.4715 (3.2); 2.4690 (4.1); 2.4650 (6.2); 2.4622 (5.4); 2.4584 (6.4); 2.4517 (6.5); 2.4449 (6.5); 2.4412 (5.6); 2.4382 (6.8); 2.4344 (4.5); 2.4318 (4.0); 2.4280 (3.4); 2.4209 (4.4); 2.4144 (3.3); 2.1733 (1.7); 2.1663 (1.4); 2.1526 (3.1); 2.1477 (6.7); 2.1409 (4.5); 2.1330 (2.4); 2.1283 (6.8); 2.1236 (6.6); 2.1217 (6.8); 2.1170 (5.7); 2.1043 (4.8); 2.0973 (6.0); 2.0928 (2.9); 2.0796 (1.9); 2.0734 (1.7); 2.0425 (10.5); 1.8742 (1.6); 1.8468 (4.1); 1.8442 (3.2); 1.8250 (2.4); 1.8222 (4.1); 1.8196 (3.4); 1.7973 (1.5); 1.7949 (1.6); 1.7306 (1.8); 1.7104 (3.3); 1.7058 (2.8); 1.6901 (2.1); 1.6850 (6.1); 1.6784 (2.5); 1.6627 (2.6); 1.6576 (4.9); 1.6524 (1.6); 1.6381 (2.3); 1.6322 (2.4); 1.6120 (1.5); 1.5468 (74.1); 1.3324 (0.9); 1.2838 (1.3); 1.2760 (3.6); 1.2581 (8.4); 1.2402 (3.2); 0.8802 (0.8); 0.1569 (0.7); 0.1462 (0.9); 0.0079 (9.9); -0.0002 (333.0); -0.0085 (9.4); -0.0503 (0.8); -0.1499 (0.9). I.2-116: N -[(2-Chloropyrimidin-4-yl)methyl]-1-(3,5-dichlorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxamide
Figure imgf000114_0001
160.0 g (2.45 mol) of sodium nitrite were added in portions to a solution of 240.0 g (1.63 mol) of 4-methylpyrimidin-2(1H)-one hydrochloride in 500 mL of glacial acetic acid and 700 mL of dioxane. Thereafter, the reaction mixture was stirred at room temperature for 3 h. The residue formed was filtered off, washed with water and dried. 220.0 g (97% of theory) of 4-[(hydroxyimino)methyl]pyrimidin-2(1H)-one are obtained as a mixture of isomers in the form of a yellowish solid. MS-ESI: [M+H]+ 140.01H NMR (500.0 MHz, d6-DMSO): δ= 6.67 (1H, d, J=6.5 Hz), 7.79 (1H, s), 7.93 (2H, d, J=6.5Hz), 11.87 (1H, s , NH), 12.50 (1H, s, OH). 30 mL POCl were added to 15.0 g (108.0 mmol) of the isomer mixture 4-[(hydroxyimino)methyl]pyrimidin-2(1H)-one in 270 mL dioxane3 (50.4g, 0.329mol). The reaction mixture was stirred at 95°C overnight, then cooled to room temperature and poured onto 150 g of ice. It was then extracted several times with ethyl acetate. The combined organic phases were washed with aqueous NaHCO3solution washed (800mL), dried over sodium sulfate, filtered and evaporated in vacuo. The residue was chromatographed over silica gel (petroleum ether:EtOAc=10:1~4:1). This procedure was repeated ten times and 97.0 g (65% of theory) of 2-chloropyrimidine-4-carbonitrile were obtained as a yellowish solid. MS-ESI: [M+H]+ 140.2.1H NMR (500.0 MHz, i.e6-DMSO): δ= 8.90 (1H, d, J=5.0 Hz), 7.64 (2H, d, J=5.0 Hz). 75.0 g (540 mmol) 2-chloropyrimidine-4-carbonitrile in 1500 mL ethanol were mixed with 30.0 g 10% Pd/C in conc. HCl (25 mL) via an air balloon at room temperature overnight. After the reaction had ended, the undissolved matter was filtered off, washed with ethanol and evaporated in vacuo. The residue was suspended in 1000 mL dichloromethane and, at 0° C., first 80 mL (58.4 g, 0.577 mol) triethylamine and then 118.0 g (540.0 mmol) di-tert-butyl dicarbonate were added. The mixture was then stirred at room temperature for a further 2 h and finally with 200 mL water quenched. The organic phase was separated and evaporated in vacuo. After chromatography over silica gel (petroleum ether: EtOAc = 10:1~6:1), 67.5 g (51.4% of theory) of tert-butyl [(2-chloropyrimidin-4-yl)methyl]carbamate were obtained as a white solid. 7.00 g (28.8 mmol) tert-butyl [(2-chloropyrimidin-4-yl)methyl]carbamate in ethyl acetate (50 mL) were treated with 20.0 mL hydrochloric acid (4M in dioxane) and stirred at room temperature overnight. After removing the solvent in vacuo, 5.00 g (96% of theory) of 1-(2-chloropyrimidin-4-yl)methanamine hydrochloride were obtained as a pink solid. MS-ESI: [M+H]+ 144
Figure imgf000115_0001
DMSO): δ= 8.84 (d, J=5.0 Hz, 4H), 7.76 (d, J=5.0 Hz, 1H), 4.28-4.24 (m, 2H). A mixture of 24.9 g (0.154 mol) 3,5-dichloroaniline and 20.0 g (0.154 mol) itaconic acid were heated together at 150 °C for 1 h. After the reaction had ended, it was cooled to room temperature, treated with hexane (500 mL) and stirred for a further 16 h. The solid was filtered off, washed with hexane and dried in vacuo at 40°C. 30.0 g (71% of theory) of 1-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxylic acid were obtained as a brown solid. 30.0 g (0.109 mol) of the 1-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxylic acid obtained above were dissolved in 120 mL of methanol and cooled to 0.degree. Then, at this temperature, it was treated with 471 mg (0.4 mL=6.0 mmol) acetyl chloride and 11.6 g (12.0 mL=109 mmol) trimethyl orthoformate and then heated at 64° C. for 1 h. The reaction mixture was then evaporated in vacuo and the residue dissolved in 750 mL dichloromethane. After washing with 500 mL of saturated aqueous sodium bicarbonate solution and 300 mL of common salt solution and drying over sodium sulfate, a crude product was obtained, which was purified chromatographically over silica gel. 20.0 g (64% of theory) of methyl 1-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxylate were obtained as a white solid. 20.0 g (0.069 mol) of the methyl 1-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxylate obtained above were dissolved in 300 ml of dry DMF under argon. 3.30 g (0.083 mol) of 60% sodium hydride and then at 0° C. 24.71 g (0.174 mol) of methyl iodide were added to this solution over a period of 20 minutes. The mixture was then heated to 10° C. and stirred at this temperature for 3 h. After the reaction had ended, it was hydrolyzed with 300 mL saturated ammonium chloride solution and extracted twice with 500 mL MTBE each time. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo. The residue was dissolved in dichloromethane and chromatographed over silica gel. 7.50 g (36% of theory) of methyl 1-(3,5-dichlorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxylate were obtained as a greenish oil. A suspension of 7.50 g (0.025 mol) of methyl 1-(3,5-dichlorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxylate obtained above in 40 mL of methanol and 40 mL of water was mixed with 10.4 g (0.248 mol) Added lithium hydroxide at room temperature and heated first at room temperature and then at 80 ° C for 1 h. After the reaction had ended, the mixture was cooled and the solvent evaporated in vacuo. The residue was taken up with 100 mL water and washed twice with 150 mL MTBE each time. Thereafter, the pH of the remaining aqueous phase was adjusted to 3-4 with 2N hydrochloric acid and the aqueous phase was extracted twice with 500 mL ethyl acetate each time. After drying the combined ethyl acetate phases over sodium sulfate, it was filtered and the Solvent removed in vacuo. The residue was suspended in 50 mL hexane (5 h), filtered off and washed with hexane. 5.40 g (purity 98%, 76% of theory) of the desired 1-(3,5-dichlorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxylic acid were obtained as a colorless solid.1H NMR (400.0 MHz, i.e1-Chloro form): δ= 1.55 (s, 3H), 2.57 (d, J=17.33 Hz, 1H), 3.17 (d, J=17.33 Hz, 1H), 3.62 (d, J=10.01 Hz, 1H), 4.26 (d, J=10.01 Hz, 1H), 7.15 (d, J=1.75 Hz, 1H) 7.56 (t, J=1.83 Hz, 2H). Under nitrogen, 80 mg (0.27 mmol) of 1-(3,5-dichlorophenyl)-3-methyl-5-oxopyrrolidine-3-carboxylic acid in 4 mL of dry THF were initially introduced, then successively with 37.5 mg (0.27 mmol) of HOBT in 1 mL THF, 55.5 mg (0.30 mmol) 1-(2-chloropyrimidin-4-yl)methanamine hydrochloride, 143.5 mg (1.11 mmol) ethyldiisopropylamine and finally treated with 69.2 mg (0.36 mmol) EDCl in 5 mL THF and stirred at room temperature for 12 h . The solution was then evaporated, taken up in dichloromethane and washed with phosphate buffer (pH 5.5). After drying over sodium sulfate and removing the solvent in vacuo, the product was taken up in dichloromethane and chromatographed over silica gel. After purification over silica gel, 50 mg (purity 97%, 42% of theory) of the product N-[(2-chloropyrimidin-4-yl)methyl]-1-(3,5-dichlorophenyl)-3-methyl-5- oxopyrrolidine-3-carboxamide as an orange semi-solid.1H NMR (400.6MHz, CDCl3): δ 8.6053 (7.4); 8.5926 (7.5); 7.5987 (15.7); 7.5942 (16.0); 7.5197 (1.8); 7.2855 (1.4); 7.2613 (327.8); 7.2538 (1.6); 7.2522 (1.3); 7.2482 (5.3); 7.2355 (4.5); 7.2341 (2.6); 7.1599 (4.0); 7.1554 (7.6); 7.1509 (3.8); 6.9976 (1.8); 6.7821 (1.0); 4.5968 (3.9); 4.5923 (3.8); 4.5911 (3.8); 4.5836 (3.8); 4.5792 (3.7); 4.3219 (3.9); 4.2975 (4.1); 4.1308 (1.0); 4.1130 (1.0); 3.6004 (4.5); 3.5760 (4.1); 3.1870 (3.8); 3.1449 (4.3); 2.5936 (4.9); 2.5515 (4.2); 2.1367 (4.8); 2.1007 (5.3); 2.0456 (4.9); 1.5900 (21.5); 1.5608 (35.5); 1.4400 (2.4); 1.4258 (2.3); 1.3324 (0.9); 1.2843 (1.4); 1.2775 (1.7); 1.2597 (4.0); 1.2419 (1.6); 0.0080 (3.6); -0.0002 (108.9); -0.0085 (3.2). I.2-121: N -Benzyl-6-(3,5-dichlorophenyl)-N,2,4-trimethyl-7-oxo-6-azabicyclo[3.2.1]oct-3-ene-8-carboxamide
Figure imgf000116_0001
Under nitrogen, 51.0 mg (0.15 mmol) of 6-(3,5-dichlorophenyl)-2,4-dimethyl-7-oxo-6-azabicyclo[3.2.1]oct-3-en-8-carboxylic acid in 2 mL of dry Submitted dichloromethane, then successively treated with 20.3 mg (0.15 mmol) HOBT in 0.5 mL dichloromethane, 20.0 mg (0.17 mmol) N-methyl-1-phenylmethanamine, 58.2 mg (0.45 mmol) ethyldiisopropylamine and finally with 37.4 mg (0.2 mmol) EDCl and stirred at room temperature for 12 h. The solution was then filtered washed twice with water, dried the organic phase and evaporated. After purification by preparative HPLC, 35.7 mg (purity 97%, 52% of theory) of the product N-benzyl-6-(3,5-dichlorophenyl)-N,2,4-trimethyl-7-oxo-6-azabicyclo [3.2.1]oct-3-ene-8-carboxamide obtained.1H NMR (400.0 MHz, CDCl3): δ 7.5915 (6.1); 7.5870 (6.3); 7.5502 (2.8); 7.5458 (2.8); 7.4354 (0.5); 7.4181 (1.4); 7.3994 (1.2); 7.3766 (0.7); 7.3588 (0.7); 7.2960 (0.6); 7.2921 (0.7); 7.2840 (2.2); 7.2770 (1.7); 7.2699 (4.4); 7.2659 (5.0); 7.2600 (54.5); 7.1812 (3.3); 7.1740 (2.2); 7.1668 (2.4); 7.1627 (2.5); 7.1197 (1.7); 7.1152 (3.0); 7.1107 (1.6); 7.0874 (0.8); 7.0831 (1.3); 7.0787 (0.7); 5.3549 (1.5); 5.3518 (1.5); 5.2782 (0.8); 4.8428 (1.6); 4.8064 (1.8); 4.6588 (0.5); 4.6172 (1.0); 4.5208 (1.0); 4.4792 (0.5); 4.3726 (2.4); 4.3352 (2.0); 4.2988 (1.7); 4.2651 (1.2); 3.4891 (7.9); 3.2234 (3.7); 3.1902 (1.7); 2.9895 (1.4); 2.9771 (1.5); 2.9582 (7.8); 2.9517 (16.0); 2.9361 (0.9); 2.7593 (0.5); 2.7535 (0.6); 2.7472 (0.6); 2.7413 (0.5); 1.8643 (4.3); 1.8593 (6.1); 1.8545 (4.4); 1.7465 (2.3); 1.7420 (3.2); 1.7373 (2.2); 1.6370 (1.2); 1.2090 (6.1); 1.1909 (6.0); 1.1487 (3.0); 1.1305 (2.9); 0.0080 (0.7); -0.0002 (21.6); -0.0085 (0.6). I.2-142: 1-(3-Chloro-5-methylphenyl)-N-[(2-chloropyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamide
Figure imgf000117_0001
A mixture of 18.5 g (0.131 mol) of 3-chloro-5-methylaniline and 17.0 g (0.131 mol) of itaconic acid were heated together at 130°C for 1 h. After the reaction had ended, MTBE (50 mL) was added at about 70° C. and the mixture was cooled to room temperature. 400 mL hexane were then added and the mixture was stirred for a further 2 h, the solid was filtered off, washed with hexane (100 mL) and dried at 40° C. in vacuo. 30.0 g (91% of theory) of 1-(3-chloro-5-methylphenyl)-5-oxopyrrolidine-3-carboxylic acid were obtained as a brown solid. 31.0 g (0.122 mol) of the 1-(3-chloro- 5-methylphenyl)-5-oxopyrrolidine-3-carboxylic acid was dissolved in 150 mL of methanol and cooled to 0°C. Then, at this temperature, it was treated with 471.0 mg (0.43 mL=6.0 mmol) acetyl chloride and 12.96 g (13.3 mL=0.122 mol) trimethyl orthoformate and then heated at 64° C. for 1 h. The reaction mixture was then evaporated in vacuo and the residue dissolved in 750 mL dichloromethane. After washing with 500 mL of saturated aqueous sodium bicarbonate solution and 300 mL of common salt solution and drying over sodium sulfate, a crude product was obtained, which was purified chromatographically over silica gel. 28.0 g (86% of theory) of methyl 1-(3-chloro-5-methylphenyl)-5-oxopyrrolidine-3-carboxylate were obtained as a white solid. Under argon, 23.0 g (0.086 mol) of the methyl-1-(3-chloro-5- methylphenyl)-3-methyl-5-oxopyrrolidine-3-carboxylate dissolved in 250 mL dry DMF and treated at 0 °C with 4.50 g (0.122 mol) 60% sodium hydride and then with 36.62 g (0.258 mol) methyl iodide. The mixture was then stirred at 0° C. for a further 1 h and warmed to room temperature. After 16 h, it was hydrolyzed with 300 mL saturated ammonium chloride solution and extracted twice with 300 mL MTBE each time. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo. The residue was dissolved in dichloromethane and chromatographed over silica gel. 8.0 g (33% of theory) of methyl 1-(3-chloro-5-methylphenyl)-3-methyl-5-oxopyrrolidine-3-carboxylate were obtained as a greenish oil. A suspension of 8.90 g (0.028 mol) of the methyl 1-(3-chloro-5-methylphenyl)-3-methyl-5-oxopyrrolidine-3-carboxylate obtained above in 50 mL of methanol and 50 mL of water was treated with 11.9 g (0.283 mol) lithium hydroxide at room temperature and heated first at room temperature and then at 80 ° C for 1 h. After the reaction had ended, the mixture was cooled and the solvent evaporated in vacuo. The residue was taken up with 100 mL water and washed twice with 100 mL MTBE each time. Thereafter, the pH of the remaining aqueous phase was adjusted to 3-4 with 2N hydrochloric acid and the aqueous phase was extracted three times with 500 mL ethyl acetate each time. After the combined ethyl acetate phases had been dried, they were filtered and the solvent removed in vacuo. The solid residue was suspended in 250 mL hexane (5 h), filtered off and washed with hexane. After drying at 40° C., 6.50 g (purity 96.5%, 86% of theory) of the desired 1-(3-chloro-5-methylphenyl)-3-methyl-5-oxopyrrolidine-3-carboxylic acid were obtained as a colorless solid.1H NMR (400.0 MHz, d1-chloro form): δ = 2.34 (s, 3 H) 2.56 (d, J=17.33 Hz, 1 H) 3.17 (d, J=17.33 Hz, 1 H) 3.63 (d, J =10.01 Hz, 1 H) 4.27 (d, J=10.01 Hz, 1 H) 6.99 (br s, 1 H) 7.32 (br s, 1 H) 7.41 (br s, 1 H). Under nitrogen, 70 mg (0.26 mmol) of 1-(3-chloro-5-methylphenyl)-3-methyl-5-oxopyrrolidine-3-carboxylic acid in 4 mL of dry THF were initially introduced, then successively with 35.3 mg (0.26 mmol) of HOBT in 1 ml THF, 61.5 mg (0.34 mmol) 2-chloropyridin-4-yl)methanaminium chloride, 135.2 mg (1.04 mmol) ethyldiisopropylamine and finally treated with 65.2 mg (0.34 mmol) EDCl in 5 mL THF and stirred at room temperature for 12 h. The solution was then evaporated, the crude product was taken up in 2.5 mL dichloromethane and purified directly on silica gel. After purification over silica gel, 99.0 mg (purity 91%, 88% of theory) of 1-(3-chloro-5-methylphenyl)-N-[(2-chloropyridin-4-yl)methyl]-3-methyl-5 -oxopyrrolidine-3-carboxamide obtained as a yellow gum.1H NMR(400.0MHz, CDCl3): δ 8.3342 (2.9); 8.3215 (2.9); 7.4361 (1.8); 7.4323 (3.2); 7.4276 (1.9); 7.2872 (2.9); 7.2628 (37.6); 7.1940 (3.5); 7.1924 (3.5); 7.1048 (2.0); 7.1031 (1.8); 7.1012 (1.9); 7.0920 (1.9); 7.0885 (1.8); 6.9815 (3.0); 6.3794 (0.8); 4.4895 (2.2); 4.4756 (3.7); 4.4614 (2.1); 4.3291 (3.1); 4.3044 (3.3); 4.1440 (0.9); 4.1262 (2.6); 4.1083 (2.7); 4.0904 (0.9); 3.5933 (3.6); 3.5686 (3.4); 3.0964 (2.9); 3.0547 (3.3); 2.9516 (0.9); 2.8673 (0.8); 2.5411 (3.7); 2.4994 (3.2); 2.3330 (16.0); 2.3320 (15.8); 2.0412 (12.3); 1.5458 (16.6); 1.2815 (0.5); 1.2752 (3.6); 1.2573 (8.0); 1.2395 (3.5); -0.0002 (13.4) I.3-4: 2-(2,5-dimethylphenyl)-N-[1-(quinolin-8-yl)-5-oxopyrrolidin-3-yl]acetamide.
Figure imgf000119_0001
Itaconic acid (100 mmol, 1 equiv) and 8-aminoquinoline (100 mmol, 1 equiv) were placed together in a heated round bottom flask and stirred at a temperature of 150 °C for 16 h. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. 1-(2-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid was obtained in the form of a colorless solid by recrystallization from ethyl acetate and used in the next reaction step without further purification.1-( Quinolin-8-yl)-5-oxopyrrolidine-3-carboxylic acid (48.8 mmol, 1 equiv.) was treated in tert. Butanol (100 mL) and treated with diphenylphosphoryl azide (58.8 mmol, 1.2 equiv) and triethylamine (146.4 mmol, 3.0 equiv). The resulting reaction mixture was stirred at 80° C. for 2 h, concentrated under reduced pressure after cooling to room temperature and the crude product obtained was taken up without further purification in a mixture of hydrochloric acid and ethyl acetate (100 mL) and stirred at room temperature for 16 h. The precipitated solid was filtered off and dried. In this way, 4-amino-1-(quinolin-8-yl)pyrrolidin-2-one could be obtained as a hydrochloride salt in the form of a colorless solid. 4-amino-1-(quinolin-8-yl)pyrrolidin-2-one Hydrochloride salt (150 mg, 0.57 mmol) was dissolved in abs. Dichloromethane (5 mL) and treated with triethylamine (0.19 mL, 1.42 mmol). After stirring at room temperature for 10 minutes, 2,5-dimethylphenylacetic acid chloride (114 mg, 0.63 mmol) was added. The resulting reaction mixture was stirred at room temperature for 2 h, treated with water and dichloromethane and thoroughly extracted. The combined organic phases were dried over magnesium sulfate, filtered off and concentrated under reduced pressure. 2-(2,5-dimethylphenyl)-N-[1-(quinolin-8-yl)-5-oxopyrrolidin-3-yl]acetamide (189 mg, 89 % of theory) in the form of a colorless solid.1H NMR (400 MHz, d6-DMSO) δ ppm 8.91 (m, 1H), 8.64 (br. d, 1H, NH), 8.46 (dd, 1H), 7.99 (m, 1H), 7.75 (d, 1H ), 7.66 (dd, 1H), 7.60 (dd, 1H), 7.04-6.98 (m, 2H), 6.92 (m, 1H), 4.59-4.53 (m, 1H), 4.31-4.27 (dd, 1H), 3.80-3.76 (dd, 1H), 3.46 (s, 2H), 2.93-2.88 (dd, 1H), 2.46-2.39 (dd, 1H), 2.22 (s, 3H). I.3-13: 2-(2,5-Dichlorophenyl)-N-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]acetamide.
Figure imgf000120_0001
Itaconic acid (100 mmol, 1 equiv) and 2-fluoroaniline (100 mmol, 1 equiv) were placed together in a heated round bottom flask and stirred at a temperature of 150 °C for 16 h. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. 1-(2-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid was obtained in the form of a colorless solid by recrystallization from ethyl acetate and used in the next reaction step without further purification. 1-(2-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (48.8 mmol, 1 equiv.) was dissolved in tert. Butanol (100 mL) and treated with diphenylphosphoryl azide (58.8 mmol, 1.2 equiv) and triethylamine (146.4 mmol, 3.0 equiv). The resulting reaction mixture was stirred at 80° C. for 2 h, concentrated under reduced pressure after cooling to room temperature and the crude product obtained was taken up without further purification in a mixture of hydrochloric acid and ethyl acetate (100 mL) and stirred at room temperature for 16 h. The precipitated solid was filtered off and dried. In this way, 4-amino-1-(2-fluorophenyl)pyrrolidin-2-one could be obtained in the form of a colorless solid. 4-amino-1-(2-fluorophenyl)pyrrolidin-2-one (150 mg, 0.65 mmol ) was in a baked round bottom flask in abs. Dichloromethane (5 mL) and treated with triethylamine (0.23 mL, 1.63 mmol). After stirring at room temperature for 10 minutes, 2,5-dichlorophenylacetic acid chloride (160 mg, 0.72 mmol) was added. The resulting reaction mixture was stirred at room temperature for 2 h, treated with water and dichloromethane and thoroughly extracted. The combined organic phases were dried over magnesium sulfate, filtered off and concentrated under reduced pressure. The crude product obtained was purified by column chromatography (gradient ethyl acetate/heptane) 2-(2,5-dichlorophenyl)-N-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]acetamide (93 mg, 38% of Theory) obtained in the form of a colorless solid.1H-NMR (400MHz, CDCl3) δ ppm 7.38-7.30 (m, 3H), 7.28-7.08 (m, 4H), 5.91-5.84 (br. m, 1H, NH), 4.75-4.67 (m, 1H), 4.14-4.10 (m, 1H ), 3.69-3.63 (m, 3H), 2.98-2.92 (dd, 1H), 2.45-2.39 (dd, 1H). I.3-14: 2-(2,5-Dichlorophenyl)-N-[1-(quinolin-8-yl)-5-oxopyrrolidin-3-yl]acetamide.
Figure imgf000121_0001
4-Amino-1-(quinolin-8-yl)pyrrolidin-2-one hydrochloride salt (150 mg, 0.57 mmol) was dissolved in abs. Dichloromethane (5 mL) and treated with triethylamine (0.19 mL, 1.42 mmol). After stirring at room temperature for 10 minutes, 2,5-dichlorophenylacetic acid chloride (140 mg, 0.63 mmol) was added. The resulting reaction mixture was stirred at room temperature for 2 h, treated with water and dichloromethane and thoroughly extracted. The combined organic phases were dried over magnesium sulfate, filtered off and concentrated under reduced pressure. 2-(2,5-Dichlorophenyl)-N-[1-(quinolin-8-yl)-5-oxopyrrolidin-3-yl]acetamide (156 mg, 66 % of theory) in the form of a colorless solid.1H NMR (400 MHz, d6-DMSO) δ ppm 8.93 (m, 1H), 8.80 (br. d, 1H, NH), 8.46 (dd, 1H), 7.99 (m, 1H), 7.75 (d, 1H ), 7.67 (dd, 1H), 7.61 (dd, 1H), 7.51 (m, 1H), 7.44 (m, 1H), 7.35 (m, 1H), 4.62-4.57 (m, 1H), 4.31-4.27 ( dd, 1H), 3.81-3.78 (dd, 1H), 3.67 (s, 2H), 2.94-2.88 (dd, 1H), 2.49-2.43 (dd, 1H). I.3-19: 2-(2,5-Dichlorophenyl)-N-[1-cyclopropyl-5-oxopyrrolidin-3-yl]acetamide.
Figure imgf000121_0002
Itaconic acid (100 mmol, 1 equiv) and cyclopropylamine (100 mmol, 1 equiv) were placed together in a heated round bottom flask and stirred at a temperature of 150 °C for 16 h. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. 1-Cyclopropyl-5-oxopyrrolidine-3-carboxylic acid was obtained in the form of a colorless solid by recrystallization from ethyl acetate and used in the next reaction step without further purification.1-Cyclopropyl-5-oxopyrrolidine -3-carboxylic acid (48.8 mmol, 1 equiv.) was added in tert. Butanol (100 mL) and treated with diphenylphosphoryl azide (58.8 mmol, 1.2 equiv) and triethylamine (146.4 mmol, 3.0 equiv). The resulting reaction mixture was stirred at 80° C. for 2 h, concentrated under reduced pressure after cooling to room temperature and the crude product obtained was taken up without further purification in a mixture of hydrochloric acid and ethyl acetate (100 mL) and stirred at room temperature for 16 h. The precipitated solid was filtered off and dried. In this way, 4-amino-1-cyclopropylpyrrolidin-2-one as a hydrochloride salt in the form of a Colorless solid be obtained.4-amino-1-cyclopropyl-pyrrolidin-2-one hydrochloride salt (150 mg, 0.85 mmol) was abs in a heated round bottom flask. Dissolved dichloromethane (5 mL) and treated with triethylamine (0.30 mL, 2.12 mmol). After stirring at room temperature for 10 minutes, 2,5-dichlorophenylacetic acid chloride (209 mg, 0.93 mmol) was added. The resulting reaction mixture was stirred at room temperature for 2 h, treated with water and dichloromethane and thoroughly extracted. The combined organic phases were dried over magnesium sulfate, filtered off and concentrated under reduced pressure. The crude product obtained was purified by column chromatography (gradient ethyl acetate/heptane) to give 2-(2,5-dichlorophenyl)-N-[1-cyclopropyl-5-oxopyrrolidin-3-yl]acetamide (222 mg, 80% of theory). obtained a colorless solid.1H NMR (400 MHz, CDCl3) δ ppm 7.34-7.30 (m, 2H), 7.28-7.23 (m, 1H), 5.96-5.89 (br. m, 1H, NH), 4.52-4.43 (m, 1H) , 3.67-3.64 (m, 1H), 3.63 (s, 2H), 3.15-3.10 (dd, 1H), 2.78-2.72 (dd, 1H), 2.65-2.61 (m, 1H), 2.23-2.18 (dd, 1H), 0.78-0-70 (m, 2H), 0.69-0.59 (m, 2H). I.4-33: 1-(4-Chlorophenyl)-3-[4-methyl-1-phenyl-5-oxopyrrolidin-3-yl]urea.
Figure imgf000122_0001
N-Phenylglycine ethyl ester (60 mmol, 1 equiv) and diisopropylethylamine (120 mmol, 2 equiv) were placed together in a heated round bottom flask, dissolved in abs. Dissolved dichloromethane (150 mL) and treated with propionyl chloride (120 mmol, 2 equiv.). The resulting reaction mixture was stirred at room temperature for 16 h and then concentrated under reduced pressure. After addition of saturated sodium bicarbonate solution and ethyl acetate, the aqueous phase was extracted three times with ethyl acetate (200 mL in total). By drying the combined organic phases over sodium sulfate, filtering off and concentrating under reduced pressure, N-propionyl-N-phenylglcin ethyl ester was obtained and used in the next reaction step without further purification. N-Propionyl-N-phenylglcin ethyl ester (60 mmol, 1.0 equiv.) was dissolved in abs. Dissolved tetrahydrofuran and carefully treated with sodium hydride (180 mmol, 3 equiv.). The resulting reaction mixture was stirred at a temperature of 65°C for 48 hours. After cooling to room temperature, the reaction mixture was quenched by adding ethanol dropwise and then concentrated under reduced pressure. By column chromatographic purification of the remaining residue (20% petroleum ether/ethyl acetate), 1-phenyl-3,5-dioxo-4-methylpyrrolidine was obtained in the form of a colorless solid.1-Phenyl-3,5-dioxo-4-methylpyrrolidine (30.0 mmol , 1 equiv.) was dissolved in dichloromethane (100 mL) and treated with hydroxylamine hydrochloride (36.0 mmol, 1.2 equiv.) and diisopropylethylamine (60 mmol, 2.0 equiv.). The resulting reaction mixture was stirred at room temperature for 16 h, concentrated under reduced pressure and the crude product obtained without further purification taken up in methanol (100 mL), treated with palladium on carbon (1.0 g) and stirred at room temperature under a hydrogen atmosphere (1 bar) for 16 h. Thereafter, the reaction mixture was filtered through Celite and concentrated under reduced pressure. The residue was taken up in acetic acid (50 mL) and treated with sodium cyanoborohydride (60 mmol, 2 equiv). The reaction mixture was stirred at room temperature for a further 16 h and again concentrated. The residue which remained was purified by column chromatography (20% petroleum ether/ethyl acetate) and 3-amino-4-methyl-1-phenyl-5-oxopyrrolidine was obtained in the form of a colorless solid.3-amino-4-methyl-1-phenyl-5- Oxopyrrolidine (1.0 mmol, 1 equiv.) was dissolved in abs. Dichloromethane (5 mL) and treated with diisopropylethylamine (2.0 mmol, 2 equiv.). After stirring at room temperature for 10 minutes, a solution of 4-chlorophenyl isocyanate (1.2 mmol, 1.2 equiv.) in abs. dichloromethane (2 mL). The resulting reaction mixture was stirred at room temperature for 16 h and then concentrated under reduced pressure. Preparative HPLC purification of the crude product obtained gave 1-(4-chlorophenyl)-3-[4-methyl-1-phenyl-5-oxopyrrolidin-3-yl]urea (213 mg, 62% of theory) in the form of a colorless received solid.1H NMR (400 MHz, d6-DMSO) δ ppm 8.80 (br.s, 1H, NH), 7.69 (d, 2H), 7.47-7.38 (m, 4H), 7.30 (d, 2H), 7.17-7.13 (m, 1H), 6.76 (br. d, 1H, NH), 4.12-4.03 (m, 2H), 3.61-3.58 (m, 1H), 2.69-2.61 (m, 1H), 1.20 (d, 3H) . I.4-36: 1-(5-Chloro-2-methylphenyl)-3-[1-phenyl-5-oxopyrrolidin-3-yl]urea.
Figure imgf000123_0001
Itaconic acid (100 mmol, 1 equiv) and aniline (100 mmol, 1 equiv) were placed together in a heated round bottom flask and stirred at a temperature of 150 °C for 16 h. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. 1-Phenyl-5-oxopyrrolidine-3-carboxylic acid was obtained in the form of a colorless solid by recrystallization from ethyl acetate and used in the next reaction step without further purification. Phenyl-5-oxopyrrolidine-3-carboxylic acid (48.8 mmol, 1 equiv.) was treated in tert. Butanol (100 mL) and treated with diphenylphosphoryl azide (58.8 mmol, 1.2 equiv) and triethylamine (146.4 mmol, 3.0 equiv). The resulting reaction mixture was stirred at 80° C. for 2 h, concentrated under reduced pressure after cooling to room temperature and the crude product obtained was taken up without further purification in a mixture of hydrochloric acid and ethyl acetate (100 mL) and stirred at room temperature for 16 h. The precipitated solid was filtered off and dried. In this way, 4-amino-1-phenylpyrrolidin-2-one as the hydrochloride salt could be obtained as a colorless solid be obtained. 4-Amino-1-phenylpyrrolidin-2-one hydrochloride (7.05 g, 33 mmol) was dissolved in abs. Dissolved in acetonitrile (20 mL), treated with triethylamine (6.01 mL, 43.09 mmol) and cooled to 10 °C. After stirring for 10 minutes at a temperature of 10°C, a solution of 5-chloro-2-methylphenyl isocyanate (5.00 g, 29.83 mmol) was added dropwise. The resulting reaction mixture was stirred at room temperature for 4 h, treated with ethyl acetate, water and dilute hydrochloric acid, and the aqueous phase was thoroughly extracted with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered off and concentrated under reduced pressure. By preparative HPLC purification of the crude product obtained was 1- (5-chloro-2-methylphenyl) -3- [1-phenyl-5-oxopyrrolidin-3-yl] urea (7.75 g, 68% of theory) in the form of a colorless received solid.1H NMR (400 MHz, d6-DMSO) δ ppm 8.06 (d, 1H), 7.73 (br. s, 1H, NH), 7.68 (m, 2H), 7.41-7.36 (m, 2H), 7.30 (d , 1H), 7.16-7.12 (m, 2H), 6.92-6.69 (m, 1H), 4.41-4.36 (m, 1H), 4.18-4.14 (m, 1H), 3.70-3.66 (dd, 1H), 3.00 -2.94 (dd, 1H), 2.43-2.38 (dd, 1H), 2.14 (s, 3H). I.5-4: 1-(2,5-Dichlorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea.
Figure imgf000124_0001
Itaconic acid (100 mmol, 1 equiv) and 2-fluoroaniline (100 mmol, 1 equiv) were placed together in a heated round bottom flask and stirred at a temperature of 150 °C for 16 h. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. 1-(2-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid was obtained in the form of a colorless solid by recrystallization from ethyl acetate and used in the next reaction step without further purification. 1-(2-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (48.8 mmol, 1 equiv.) was dissolved in tert. Butanol (100 mL) and treated with diphenylphosphoryl azide (58.8 mmol, 1.2 equiv) and triethylamine (146.4 mmol, 3.0 equiv). The resulting reaction mixture was stirred at 80° C. for 2 h, concentrated under reduced pressure after cooling to room temperature and the crude product obtained was taken up without further purification in a mixture of hydrochloric acid and ethyl acetate (100 mL) and stirred at room temperature for 16 h. The precipitated solid was filtered off and dried. In this way, 4-amino-1-(2-fluorophenyl)pyrrolidin-2-one could be obtained in the form of a colorless solid. 4-amino-1-(2-fluorophenyl)pyrrolidin-2-one (150 mg, 0.65 mmol ) was in a baked round bottom flask in abs. Dichloromethane (5 mL) and treated with triethylamine (0.23 mL, 1.63 mmol). After stirring at room temperature for 10 minutes, 2,5-dichlorophenyl isothiocyanate (146 mg, 0.72 mmol) was added. The resulting reaction mixture was stirred at room temperature for 2 h Water and dichloromethane are added and extracted thoroughly. The combined organic phases were dried over magnesium sulfate, filtered off and concentrated under reduced pressure. The crude product obtained was purified by column chromatography (gradient ethyl acetate/heptane) to give 1-(2,5-dichlorophenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea (176 mg, 68% of Theory) obtained in the form of a colorless solid.1H NMR (400 MHz, CDCl3) δ ppm 7.86 (br. d, 1H, NH), 7.75 (br. s, 1H, NH), 7.45-7.30 (m, 3H), 7.28-7.08 (m, 4H), 5.16-5.11 (m, 1H ), 4.23-4.19 (m, 1H), 3.97-3.93 (dd, 1H), 3.11-3.04 (dd, 1H), 2.53-2.48 (dd, 1H). I.5-10: 1-(5-Chloro-2-methylphenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea.
Figure imgf000125_0001
4-amino-1-(2-fluorophenyl)pyrrolidin-2-one (150 mg, 0.65 mmol) was dissolved in abs. Dichloromethane (5 mL) and treated with triethylamine (0.23 mL, 1.63 mmol). After stirring at room temperature for 10 minutes, 2-methyl-5-chlorophenyl isothiocyanate (132 mg, 0.72 mmol) was added. The resulting reaction mixture was stirred at room temperature for 2 h, treated with water and dichloromethane and thoroughly extracted. The combined organic phases were dried over magnesium sulfate, filtered off and concentrated under reduced pressure. 1-(5-Chloro-2-methylphenyl)-3-[1-(2-fluorophenyl)-5-oxopyrrolidin-3-yl]thiourea (206 mg, 84 % of theory) in the form of a colorless solid.1H NMR (400 MHz, CDCl3) δ ppm 7.52 (br. s, 1H, NH), 7.35-7.22 (m, 4H), 7.18-7.10 (m, 3H), 6.01 (br. d, 1H, NH) , 5.21-5.17 (m, 1H), 4.23-4.18 (m, 1H), 3.84-3.80 (dd, 1H), 3.05-2.99 (dd, 1H), 2.45-2.40 (dd, 1H), 2.24 (s, 3H). I.5-21: 1-(5-Chloro-2-methylphenyl)-3-[1-cyclopropyl-5-oxopyrrolidin-3-yl]thiourea.
Figure imgf000125_0002
4-amino-1-cyclopropylpyrrolidin-2-one (150 mg, 0.85 mmol) was dissolved in abs. Dissolved dichloromethane (5 mL) and treated with triethylamine (0.30 mL, 2.12 mmol). After stirring at room temperature for 10 minutes, 2-methyl-5-chlorophenyl isothiocyanate (172 mg, 0.93mmol). The resulting reaction mixture was stirred at room temperature for 2 h, treated with water and dichloromethane and thoroughly extracted. The combined organic phases were dried over magnesium sulfate, filtered off and concentrated under reduced pressure. The crude product obtained was purified by column chromatography (gradient ethyl acetate/heptane) to give 1-(5-chloro-2-methylphenyl)-3-[1-cyclopropyl-5-oxopyrrolidin-3-yl]thiourea (213 mg, 77% of theory) obtained in the form of a colorless solid.1H NMR (400 MHz, i.e6-DMSO) δ ppm 9.07 (br. s, 1H, NH), 8.18-8.10 (br. s, 1H, NH), 7.41 (m, 1H), 7.26 (m, 1H), 7.19 (m, 1H), 4.80-4.72 (m, 1H), 3.63-3.59 (dd, 1H), 3.16-3.12 (dd, 1H), 2.64-2.60 (m, 1H), 2.32 (m, 1H), 2.28-2.24 (dd, 1H ), 2.14 (s, 3H), 0.67-0.60 (m, 4H). I.5-34: 2-(5-Chloro-2-methylphenyl)-N-[1-(quinolin-8-yl)-5-oxopyrrolidin-3-yl]thiourea.
Figure imgf000126_0001
4-Amino-1-(quinolin-8-yl)pyrrolidin-2-one hydrochloride salt (150 mg, 0.57 mmol) was dissolved in abs. Dichloromethane (5 mL) and treated with triethylamine (0.19 mL, 1.42 mmol). After stirring at room temperature for 10 minutes, 5-chloro-2-methylphenyl isothiocyanate (115 mg, 0.63 mmol) was added. The resulting reaction mixture was stirred at room temperature for 2 h, treated with water and dichloromethane and thoroughly extracted. The combined organic phases were dried over magnesium sulfate, filtered off and concentrated under reduced pressure. 2-(5-Chloro-2-methylphenyl)-N-[1-(quinolin-8-yl)-5-oxopyrrolidin-3-yl]thiourea (100 mg , 43% of theory) in the form of a colorless solid.1H NMR (400 MHz, d6-DMSO) δ ppm 9.24 (m, 1H), 8.87 (m, 1H), 8.46 (dd, 1H), 8.42-8.33 (br. s, 1H, NH), 7.99 (m , 1H), 7.74 (d, 1H), 7.68-7.64 (dd, 1H), 7.61 (dd, 1H), 7.51 (m, 1H), 7.44 (m, 1H), 7.27 (m, 1H), 7.21 ( m, 1H), 5.14-5.08 (m, 1H), 4.37-4.33 (dd, 1H), 3.97-3.94 (dd, 1H), 3.02-2.96 (dd, 1H), 2.68-2.59 (dd, 1H), 2.18 (s, 3H). In analogy to the preparation examples given above and recited at the appropriate point and taking into account the general information on the preparation of pyrrolidinones of the general formula (I), the compounds mentioned below are obtained, Table I.1: Preferred for the use of compounds of formula (I.1) are the compounds I.1-1 to I.1-605, wherein R1, R4, R13 and X have the meanings of Table I.1 given in the respective row and R3, R5, R6, R7 and R14 are hydrogen and where X is a moiety O-R36 or N(R15)r35 stands. The stereochemistry at carbon C-2 is defined by "RAC" for a mixture of both stereo configurations at carbon C-2, "Ent-1" and "Ent-2" for one enantiomer (or diastereomer if there are several stereocenters in the molecule) with one Stereo configuration given at carbon C-2.
Figure imgf000127_0001
Table I.1
Figure imgf000127_0002
Figure imgf000128_0001
Figure imgf000129_0001
Figure imgf000130_0001
Figure imgf000131_0001
Figure imgf000132_0001
Figure imgf000133_0001
Figure imgf000134_0001
Figure imgf000135_0001
Figure imgf000136_0001
Figure imgf000137_0001
Figure imgf000138_0001
Figure imgf000139_0001
Figure imgf000140_0001
Figure imgf000141_0001
Figure imgf000142_0002
Tabelle I.2: Bevorzugt für die Verwendung von Verbindungen der Formel (I.2) sind die Verbindungen I.2-1 bis I.2-182, worin R1, R3, R4, R5, R20, R21 und R37 die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.2 haben und R2, R6 und R22 Wasserstoff sind. Die mit einem Stern (*) gekennzeichneten Bindungen der gemeinsam von R3 und R5 gebildeten Gruppen geben die Bindungen zum Pyrrolidinonring an. Bei den mit zwei Sternen (**) gekennzeichneten Gruppierungen bilden R21 und R37 gemeinsam mit dem Kohlenstoffatom, an das sie gebunden sind, ein Ringsystem, das gegebenenfalls auch bicyclisch sein kann. Das so unter Einbeziehung des Kohlenstoffatoms gebildete Ringsystem wird dann entsprechend in einer gemeinsamen Spalte für R21 und R37 angegeben.
Figure imgf000142_0001
Tabelle I.2
Figure imgf000143_0001
Figure imgf000144_0001
Figure imgf000145_0001
Figure imgf000146_0001
Figure imgf000142_0002
Table I.2: Preferred for the use of compounds of formula (I.2) are the compounds I.2-1 to I.2-182, wherein R 1 , R 3 , R 4 , R 5 , R 20 , R 21 and R 37 have the meanings given in Table I.2 in the respective row and R 2 , R 6 and R 22 are hydrogen. The bonds marked with an asterisk (*) of the groups formed jointly by R3 and R5 indicate the bonds to the pyrrolidinone ring. In the case of the groups marked with two asterisks (**), R 21 and R 37 together with the carbon atom to which they are attached form a ring system which can optionally also be bicyclic. The ring system formed in this way, including the carbon atom, is then indicated accordingly in a common column for R 21 and R 37 .
Figure imgf000142_0001
Table I.2
Figure imgf000143_0001
Figure imgf000144_0001
Figure imgf000145_0001
Figure imgf000146_0001
Figure imgf000147_0002
Tabelle I.3: Bevorzugt für die Verwendung von Verbindungen der Formel (I.3) sind die Verbindungen I.3-1 bis I.3-37, worin R1, R3, R5, R10 und R37 die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.3 haben und R2, R4, R6, R11 und R12 Wasserstoff sind.
Figure imgf000147_0001
Tabelle I.3
Figure imgf000147_0003
Figure imgf000147_0002
Table I.3: Preferred for the use of compounds of the formula (I.3) are the compounds I.3-1 to I.3-37, in which R 1 , R 3 , R 5 , R 10 and R 37 are in have the meanings of Table I.3 given in the respective row and R 2 , R 4 , R 6 , R 11 and R 12 are hydrogen.
Figure imgf000147_0001
Table I.3
Figure imgf000147_0003
Figure imgf000148_0002
Tabelle I.4: Bevorzugt für die Verwendung von Verbindungen der Formel (I.4) sind die Verbindungen I.4-1 bis I.4-141, worin R1, R3, R5 und R37 die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.4 haben und R2, R4, R6, R8 und R9 Wasserstoff sind.
Figure imgf000148_0001
Tabelle I.4
Figure imgf000149_0001
Figure imgf000150_0001
Figure imgf000151_0001
Figure imgf000148_0002
Table I.4: Preferred for the use of compounds of the formula (I.4) are the compounds I.4-1 to I.4-141, in which R 1 , R 3 , R 5 and R 37 are those in the respective line have the meanings given in Table I.4 and R 2 , R 4 , R 6 , R 8 and R 9 are hydrogen.
Figure imgf000148_0001
Table I.4
Figure imgf000149_0001
Figure imgf000150_0001
Figure imgf000151_0001
Figure imgf000152_0002
Tabelle I.5: Bevorzugt für die Verwendung von Verbindungen der Formel (I.5) sind die Verbindungen I.5-1 bis I.5-34, worin R1, R3, R5 und R37 die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.5 haben und R2, R4 und R6 Wasserstoff sind. ,
Figure imgf000152_0001
Tabelle I.5 4
Figure imgf000152_0003
Figure imgf000152_0002
Table I.5: Preferred for the use of compounds of the formula (I.5) are the compounds I.5-1 to I.5-34, in which R 1 , R 3 , R 5 and R 37 are those in the respective line have the meanings given in Table I.5 and R 2 , R 4 and R 6 are hydrogen. ,
Figure imgf000152_0001
Table I.5 4
Figure imgf000152_0003
Figure imgf000153_0001
Spektroskopische Daten ausgewählter Tabellenbeispiele: Die nachfolgend aufgeführten spektroskopischen Daten ausgewählter Tabellenbeispiele wurden entweder über klassische NMR-Interpretation und/oder über 1H-NMR-Peak-Listenverfahren ausgewertet. a) Klassische Interpretation: Beispiel Nr. I.4-3: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.17 (d, 1H), 8.09 (br. s, 1H, NH), 7.64 (d, 1H), 7.58 (d, 1H), 7.46-7.34 (m, 4H), 7.26 (m, 1H), 6.98 (m, 1H), 4.49-4.44 (m, 1H), 4.05-4.00 (m, 1H), 3.59-3.53 (dd, 1H), 2.94-2.87 (dd, 1H), 2.37-2.31 (dd, 1H). Beispiel Nr. I.4-4: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.50 (br. s, 1H, NH), 7.55 (d, 2H), 7.43 (d, 2H), 7.28 (d, 2H), 7.19 (d, 2H), 6.81 (br. d, 1H, NH), 4.42-4.36 (m, 1H), 4.14-4.08 (m, 1H), 3.69-3.63 (dd, 1H), 2.94-2.87 (dd, 1H), 2.47-2.40 (dd, 1H), 2.28 (s, 3H). Beispiel Nr. I.4-15: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.81 (s, 1H), 8.42 (br. m, 1H, NH), 7.95 (m, 1H), 7.57 (d, 2H), 7.39 (d, 1H), 7.00 (br. d, 1H, NH), 6.96 (d, 2H), 4.42-4.38 (m, 1H), 4.14-4.08 (m, 1H), 3.75 (s, 3H), 3.67-3.63 (dd, 1H), 2.93-2.86 (dd, 1H), 2.47-2.41 (dd, 1H). Beispiel Nr. I.4-16: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.89 (s, 1H), 8.42 (br. m, 1H, NH), 7.96 (m, 1H), 7.58 (m, 1H), 7.46-7.39 (m, 4H), 7.00 (br. d, 1H, NH), 4.51-4.45 (m, 1H), 4.02-3.97 (m, 1H), 3.59-3.54 (dd, 1H), 2.89- 2.81 (dd, 1H), 2.46-2.39 (dd, 1H). Beispiel Nr. I.4-17: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.62 (br. s, 1H, NH), 7.89 (s, 1H), 7.54 (d, 1H), 7.45-7.35 (m, 3H), 7.29 (d, 2H), 6.80 (br. d, 1H, NH), 4.51-4.45 (m, 1H), 4.02-3.97 (m, 1H), 3.59-3.54 (dd, 1H), 2.85- 2.81 (dd, 1H), 2.44-2.37 (dd, 1H). Beispiel Nr. I.4-18: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.69 (br. s, 1H, NH), 7.59 (d, 1H), 7.49-7.34 (m, 5H), 7.28 (d, 2H), 7.22 (d, 1H), 6.82 (br. d, 1H, NH), 4.43-4.38 (m, 1H), 4.18-4.14 (m, 1H), 3.72-3.68 (dd, 1H), 2.96- 2.91 (dd, 1H), 2.46 (dd, 1H). Beispiel Nr. I.4-19: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.18 (m, 1H), 8.00 (br. s, 1H, NH), 7.91 (s, 1H), 7.65 (d, 1H), 7.57 (d, 1H), 7.48-7.39 (m, 2H), 7.30-7.22 (m, 2H), 6.99-6.96 (m, 1H), 4.43-4.38 (m, 1H), 4.19-4.14 (m, 1H), 3.73-3.69 (dd, 1H), 3.03-2.96 (dd, 1H), 2.46-2.40 (dd, 1H). Beispiel Nr. I.4-20: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.18 (d, 1H), 8.00 (br. s, 1H, NH), 7.72 (d, 2H), 7.67 (d, 1H), 7.48-7.42 (m, 3H), 7.22 (m, 1H), 6.99-6.96 (m, 1H), 4.43-4.37 (m, 1H), 4.18-4.13 (m, 1H), 3.70-3.66 (dd, 1H), 3.03-2.95 (dd, 1H), 2.47-2.39 (dd, 1H). Beispiel Nr. I.4-27: 1H-NMR (400 MHz, d6-DMSO) δ ppm 9.26 (br. s, 1H, NH), 8.92 (br. m, 1H), 7.73 (d, 2H), 7.57 (m, 1H), 7.46 (d, 2H), 7.12 (d, 1H), 6.81 (d, 1H), 4.51-4.41 (m, 1H), 4.19-4.14 (m, 1H), 3.75-3.70 (dd, 1H), 3.02-2.94 (dd, 1H), 2.47 (m, 1H), 2.33 (s, 3H). Beispiel Nr. I.4-31: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.82 (s, 1H), 8.42 (d, 1H), 7.95-7.91 (m, 1H), 7.71 (d, 2H), 7.45 (d, 2H), 7.38 (d, 1H), 7.03 (m, 1H), 4.45-4.38 (m, 1H), 4.16-4.11 (m, 1H), 3.71-3.66 (dd, 1H), 2.97-2.90 (dd, 1H), 2.49-2.45 (dd, 1H). Beispiel Nr. I.4-32: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.89 (s, 1H), 8.43 (d, 1H), 7.97-7.93 (m, 1H), 7.59 (d, 1H), 7.46- 7.38 (m, 4H), 7.01 (m, 1H), 4.52-4.45 (m, 1H), 4.02-3.97 (m, 1H), 3.59-3.54 (dd, 1H), 2.89-2.82 (dd, 1H), 2.45-2.38 (dd, 1H). Beispiel Nr. I.4-34: 1H-NMR (400 MHz, d6-DMSO) δ ppm 9.26 (s, 1H), 8.93 (br. m, 1H), 7.68-7.65 (m, 2H), 7.58 (m, 1H), 7.40-7.34 (m, 2H), 7.17-7.10 (m, 2H), 6.80 (d, 1H), 4.52-4.45 (m, 1H), 4.21-4.16 (m, 1H), 3.76-3.72 (dd, 1H), 3.01-2.94 (dd, 1H), 2.49-2.43 (m, 1H), 2.32 (s, 3H). Beispiel Nr. I.4-37: 1H-NMR (400 MHz, d6-DMSO) δ ppm 9.35 (s, 1H), 8.84 (br. m, 1H), 7.63-7.59 (m, 1H), 7.50 (d, 2H), 7.20-7.13 (m, 3H), 6.84 (d, 1H), 4.48-4.43 (m, 1H), 4.18-4.13 (m, 1H), 3.72-3.68 (dd, 1H), 2.98-2.92 (dd, 1H), 2.49-2.43 (m, 1H), 2.35 (s, 3H), 2.28 (s, 3H). Beispiel Nr. I.4-38: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.59 (br. s, 1H, NH), 7.55 (d, 2H), 7.42 (d, 2H), 7.29 (d, 2H), 6.96 (d, 2H), 6.81 (br. d, 1H, NH), 4.40-4.37 (m, 1H), 4.14-4.08 (m, 1H), 3.75 (s, 3H), 3.65-3.61 (dd, 1H), 2.92-2.85 (dd, 1H), 2.45-2.39 (dd, 1H). Beispiel Nr. I.4-41: 1H-NMR (400 MHz, d6-DMSO) δ ppm 8.18 (d, 1H), 8.00 (br. s, 1H, NH), 7.64 (d, 1H), 7.58 (d, 2H), 7.42 (d, 1H), 7.25 (m, 1H), 6.99-6.90 (m, 3H), 4.40-4.37 (m, 1H), 4.17-4.11 (m, 1H), 3.75 (s, 3H), 3.65- 3.61 (dd, 1H), 2.97-2.90 (dd, 1H), 2.39-2.34 (dd, 1H). b) 1H-NMR-Peak-Listenverfahren: Zu jedem Signalpeak wird beim 1H-NMR-Peak-Listenverfahren erst der δ-Wert in ppm und dann die Signalintensität in runden Klammern aufgeführt. Die δ-Wert – Signalintensitäts- Zahlenpaare von verschiedenen Signalpeaks werden durch Semikolons voneinander getrennt aufgelistet. Die Peakliste eines Beispieles hat daher die Form: δ1 (Intensität1); δ2 (Intensität2);……..; δi (Intensitäti);……; δn (Intensitätn) Die Intensität scharfer Signale korreliert mit der Höhe der Signale in einem gedruckten Beispiel eines NMR-Spektrums in cm und zeigt die wirklichen Verhältnisse der Signalintensitäten. Bei breiten Signalen können mehrere Peaks oder die Mitte des Signals und ihre relative Intensität im Vergleich zum intensivsten Signal im Spektrum gezeigt werden. Zur Kalibrierung der chemischen Verschiebung von 1H- NMR-Spektren benutzen wir Tetramethylsilan und/oder die chemische Verschiebung des Lösungsmittels, besondern im Falle von Spektren, die in DMSO gemessen werden. Daher kann in NMR-Peaklisten der Tetramethylsilan-Peak vorkommen, muss es aber nicht. Die Listen der 1H-NMR-Peaks sind ähnlich den klassischen 1H-NMR-Ausdrucken und enthalten somit gewöhnlich alle Peaks, die bei einer klassischen NMR-Interpretation aufgeführt werden. Darüber hinaus können sie wie klassische 1H-NMR-Ausdrucke Lösungsmittelsignale, Signale von Stereoisomeren der Zielverbindungen, die ebenfalls Gegenstand der Erfindung sind, und/oder Peaks von Verunreinigungen zeigen. Bei der Angabe von Verbindungssignalen im Delta-Bereich von Lösungsmitteln und/oder Wasser sind in unseren Listen von 1H-NMR-Peaks die gewöhnlichen Lösungsmittelpeaks, zum Beispiel Peaks von DMSO in DMSO-D6 und der Peak von Wasser, gezeigt, die gewöhnlich im Durchschnitt eine hohe Intensität aufweisen. Die Peaks von Stereoisomeren der Targetverbindungen und/oder Peaks von Verunreinigungen haben gewöhnlich im Durchschnitt eine geringere Intensität als die Peaks der Zielverbindungen (zum Beispiel mit einer Reinheit von >90%). Solche Stereoisomere und/oder Verunreinigungen können typisch für das jeweilige Herstellungsverfahren sein. Ihre Peaks können somit dabei helfen, die Reproduktion unseres Herstellungsverfahrens anhand von “Nebenprodukt-Fingerabdrücken” zu erkennen. Einem Experten, der die Peaks der Zielverbindungen mit bekannten Verfahren (MestreC, ACD- Simulation, aber auch mit empirisch ausgewerteten Erwartungswerten) berechnet, kann je nach Bedarf die Peaks der Zielverbindungen isolieren, wobei gegebenenfalls zusätzliche Intensitätsfilter eingesetzt werden. Diese Isolierung wäre ähnlich dem betreffenden Peak-Picking bei der klassischen 1H-NMR- Interpretation. Weitere Details zu 1H-NMR-Peaklisten können der Research Disclosure Database Number 564025 entnommen werden. I.1-001: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.5273 (2.0); 7.5223 (2.0); 7.5084 (3.3); 7.5029 (3.8); 7.4915 (2.3); 7.4850 (2.1); 7.2549 (0.9); 7.2500 (1.3); 7.2354 (3.2); 7.2306 (2.6); 7.2210 (4.2); 7.2169 (11.7); 7.1976 (6.6); 7.1784 (1.9); 4.7268 (3.0); 4.6869 (3.5); 4.2494 (3.9); 4.2092 (3.3); 3.7943 (0.8); 3.7839 (1.2); 3.7730 (1.8); 3.7635 (2.0); 3.7532 (1.8); 3.7426 (1.4); 3.7323 (0.5); 3.3770 (8.7); 3.1663 (3.3); 2.7741 (0.6); 2.7116 (3.2); 2.7014 (3.2); 2.6717 (4.3); 2.6615 (4.0); 2.5239 (2.2); 2.5192 (3.2); 2.5105 (50.3); 2.5059 (111.3); 2.5013 (155.7); 2.4967 (108.8); 2.4921 (48.1); 2.4468 (1.3); 2.4301 (1.1); 2.4057 (6.4); 2.3889 (2.1); 2.3835 (5.6); 2.3658 (4.0); 2.3517 (0.7); 2.3437 (3.4); 2.3328 (0.7); 2.3280 (1.0); 2.3234 (0.7); 2.2930 (1.5); 2.2801 (1.6); 2.2685 (2.8); 2.2557 (2.7); 2.2269 (3.6); 2.2171 (2.2); 2.2045 (1.4); 2.1993 (1.2); 2.1869 (1.8); 2.1803 (0.9); 2.1746 (0.7); 2.1677 (1.2); 2.1620 (1.0); 2.1432 (0.6); 1.7575 (1.7); 1.7466 (1.7); 1.7357 (1.9); 1.7284 (1.0); 1.7228 (1.0); 1.7180 (1.1); 1.7039 (1.1); 1.6914 (0.8); 1.6346 (0.6); 1.6181 (0.8); 1.6008 (0.6); 1.4445 (0.9); 1.4247 (1.2); 1.4052 (1.2); 1.3877 (0.7); 0.8894 (16.0); 0.8729 (15.3); -0.0002 (15.0). I.1-002: 1H-NMR (400.1 MHz, d6-DMSO): δ= 12.5234 (0.5); 12.4463 (0.6); 12.4011 (0.6); 12.3590 (0.6); 12.3360 (0.6); 12.3258 (0.6); 12.2780 (0.7); 12.1966 (0.5); 12.1506 (0.6); 12.1440 (0.7); 12.0718 (0.6); 11.9413 (0.6); 7.8181 (1.0); 7.3820 (2.6); 7.3781 (2.8); 7.3614 (5.7); 7.3576 (6.4); 7.3516 (3.8); 7.3354 (6.3); 7.3318 (5.8); 7.3157 (3.7); 7.3111 (3.4); 7.2096 (2.9); 7.2057 (3.4); 7.1967 (3.7); 7.1897 (6.5); 7.1858 (6.7); 7.1770 (6.4); 7.1734 (7.0); 7.1693 (4.9); 7.1654 (4.3); 7.1564 (3.9); 7.1531 (4.1); 7.1289 (0.6); 7.0951 (6.4); 7.0791 (8.9); 7.0600 (4.8); 7.0447 (0.9); 4.7423 (9.6); 4.7028 (11.4); 4.6780 (0.5); 4.2544 (12.5); 4.2148 (10.8); 3.8881 (0.5); 3.7898 (2.2); 3.7796 (4.0); 3.7687 (5.6); 3.7581 (6.4); 3.7484 (5.9); 3.7379 (4.7); 3.7278 (2.4); 3.6940 (0.7); 3.6517 (0.6); 3.6114 (0.7); 3.5977 (3.7); 3.5672 (0.9); 3.5600 (1.0); 3.5540 (1.1); 3.5249 (1.3); 3.5026 (1.4); 3.3613 (79.3); 3.1682 (10.0); 3.1265 (0.8); 3.1082 (0.8); 3.0944 (0.8); 3.0342 (0.6); 2.9971 (0.6); 2.7039 (9.7); 2.6935 (9.8); 2.6743 (4.0); 2.6698 (5.5); 2.6642 (14.6); 2.6538 (12.4); 2.5566 (2.4); 2.5520 (2.6); 2.5472 (1.4); 2.5398 (2.5); 2.5232 (7.9); 2.5185 (11.8); 2.5099 (249.1); 2.5053 (560.3); 2.5007 (795.0); 2.4961 (586.7); 2.4916 (296.0); 2.4499 (7.0); 2.4287 (5.2); 2.4192 (4.3); 2.4042 (10.1); 2.4007 (16.0); 2.3876 (7.2); 2.3788 (15.7); 2.3724 (4.6); 2.3609 (12.0); 2.3520 (2.9); 2.3388 (11.3); 2.3323 (4.7); 2.3274 (5.6); 2.3232 (4.1); 2.3185 (2.5); 2.2891 (5.3); 2.2761 (5.7); 2.2646 (8.5); 2.2516 (9.1); 2.2366 (1.7); 2.2205 (8.2); 2.2116 (6.6); 2.2067 (5.9); 2.1966 (5.3); 2.1914 (4.4); 2.1859 (3.1); 2.1791 (6.2); 2.1721 (3.4); 2.1663 (2.6); 2.1594 (4.1); 2.1537 (3.7); 2.1346 (2.1); 2.0720 (4.0); 1.8683 (0.7); 1.7841 (1.0); 1.7612 (2.6); 1.7562 (5.6); 1.7451 (5.6); 1.7328 (6.1); 1.7268 (3.6); 1.7212 (3.5); 1.7149 (4.2); 1.7023 (3.7); 1.6901 (2.5); 1.2552 (0.6); 0.9771 (0.6); 0.0082 (3.3) I.1-003: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.3726 (10.8); 7.3860 (2.9); 7.3820 (3.1); 7.3656 (6.0); 7.3615 (6.6); 7.3554 (3.4); 7.3458 (4.3); 7.3395 (6.5); 7.3354 (5.7); 7.3193 (3.6); 7.3153 (3.4); 7.2112 (4.0); 7.2073 (4.3); 7.1985 (4.1); 7.1946 (4.9); 7.1913 (7.5); 7.1875 (8.0); 7.1785 (7.3); 7.1750 (8.2); 7.1710 (5.1); 7.1670 (5.0); 7.1582 (4.3); 7.1545 (4.7); 7.0958 (7.8); 7.0799 (10.5); 7.0765 (9.7); 7.0604 (5.4); 4.7435 (12.3); 4.7039 (14.3); 4.2546 (16.0); 4.2150 (13.8); 3.7886 (2.6); 3.7781 (4.9); 3.7672 (6.9); 3.7572 (7.4); 3.7472 (6.8); 3.7367 (5.4); 3.7261 (2.2); 3.3520 (1.4); 3.3265 (262.8); 3.2764 (1.3); 2.7083 (13.1); 2.6981 (13.3); 2.6756 (1.7); 2.6684 (17.1); 2.6582 (16.1); 2.5414 (0.6); 2.5246 (2.6); 2.5199 (4.1); 2.5112 (54.6); 2.5066 (116.9); 2.5020 (160.6); 2.4974 (109.1); 2.4928 (47.5); 2.4478 (3.6); 2.4304 (4.2); 2.4210 (2.6); 2.4064 (10.6); 2.4021 (19.0); 2.3892 (7.7); 2.3801 (19.3); 2.3723 (3.8); 2.3622 (14.6); 2.3508 (1.9); 2.3402 (14.1); 2.3289 (1.6); 2.3242 (1.1); 2.3197 (0.6); 2.2899 (6.2); 2.2770 (6.9); 2.2655 (11.3); 2.2526 (11.0); 2.2374 (1.1); 2.2241 (9.0); 2.2209 (9.6); 2.2188 (9.2); 2.2129 (6.6); 2.2103 (6.2); 2.2069 (6.6); 2.1965 (5.9); 2.1909 (4.6); 2.1858 (2.6); 2.1787 (7.2); 2.1721 (3.7); 2.1665 (2.6); 2.1594 (4.7); 2.1533 (4.2); 2.1350 (2.4); 2.0748 (0.8); 1.7822 (1.1); 1.7601 (3.1); 1.7543 (7.0); 1.7431 (7.2); 1.7355 (4.6); 1.7301 (7.2); 1.7250 (4.2); 1.7194 (4.0); 1.7136 (5.0); 1.7005 (4.4); 1.6878 (2.9); 0.0080 (1.6); 0.0063 (0.5); 0.0055 (0.6); 0.0047 (0.7); 0.0039 (0.8); 0.0022 (2.2); -0.0002 (53.4); -0.0051 (1.0); -0.0059 (0.7); -0.0068 (0.6); -0.0085 (1.6) I.1-004: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.1978 (0.8); 7.3828 (0.5); 7.3780 (0.4); 7.3621 (1.2); 7.3577 (1.1); 7.3414 (1.2); 7.3370 (1.3); 7.3163 (0.7); 7.2178 (0.3); 7.2142 (0.4); 7.2056 (0.7); 7.1942 (1.1); 7.1858 (1.4); 7.1774 (1.2); 7.1738 (1.3); 7.1653 (0.9); 7.1532 (0.6); 7.0797 (1.4); 7.0636 (0.7); 4.7699 (1.0); 4.7432 (1.3); 4.7300 (1.2); 4.7031 (1.4); 4.3015 (1.2); 4.2554 (1.8); 4.2153 (1.4); 3.9266 (0.4); 3.9162 (0.5); 3.9053 (0.6); 3.8949 (0.6); 3.8846 (0.4); 3.8383 (16.0); 3.7797 (0.5); 3.7701 (0.8); 3.7600 (0.9); 3.7491 (0.8); 3.7392 (0.6); 3.3704 (18.0); 3.1686 (1.1); 2.9541 (0.6); 2.9442 (0.6); 2.9160 (0.8); 2.9060 (0.7); 2.7041 (1.2); 2.6938 (1.2); 2.6747 (0.5); 2.6699 (0.7); 2.6645 (1.8); 2.6540 (1.6); 2.6354 (0.7); 2.6128 (0.7); 2.5970 (0.6); 2.5747 (0.7); 2.5616 (0.6); 2.5576 (0.6); 2.5530 (0.4); 2.5234 (1.0); 2.5185 (1.7); 2.5101 (31.6); 2.5055 (68.7); 2.5009 (96.0); 2.4964 (70.2); 2.4919 (35.2); 2.4548 (1.0); 2.4497 (1.2); 2.4457 (1.3); 2.4315 (1.2); 2.4141 (1.1); 2.4060 (1.6); 2.4012 (2.0); 2.3887 (1.1); 2.3792 (2.0); 2.3736 (0.7); 2.3611 (1.5); 2.3509 (0.4); 2.3391 (1.4); 2.3328 (1.0); 2.3277 (0.8); 2.3201 (0.7); 2.3085 (0.8); 2.2962 (0.8); 2.2898 (0.8); 2.2765 (0.7); 2.2649 (1.4); 2.2520 (1.3); 2.2481 (1.0); 2.2352 (0.6); 2.2206 (1.3); 2.2119 (1.1); 2.1969 (1.0); 2.1918 (0.9); 2.1788 (0.8); 2.1723 (0.6); 2.1664 (0.4); 2.1604 (0.5); 2.1544 (0.5); 1.8706 (0.4); 1.8587 (0.5); 1.8479 (0.5); 1.8428 (0.5); 1.8363 (0.4); 1.8293 (0.4); 1.8166 (0.3); 1.7621 (0.3); 1.7568 (0.7); 1.7458 (0.7); 1.7329 (0.8); 1.7275 (0.5); 1.7218 (0.4); 1.7157 (0.5); 1.7030 (0.5); 0.0082 (0.5); 0.0000 (17.0) I.1-005: 1H-NMR (400.1 MHz, d6-DMSO): δ= 8.1838 (0.6); 8.1628 (0.7); 8.1443 (0.5); 8.1236 (0.5); 8.1049 (1.0); 8.0829 (1.1); 7.3769 (0.6); 7.3571 (1.3); 7.3337 (1.3); 7.3113 (0.7); 7.2067 (0.6); 7.1868 (1.4); 7.1742 (1.4); 7.1538 (0.7); 7.0893 (1.0); 7.0733 (1.6); 7.0571 (0.8); 4.7542 (1.4); 4.7372 (0.6); 4.7145 (1.6); 4.6965 (0.8); 4.3978 (1.0); 4.3862 (1.0); 4.3755 (1.0); 4.3640 (1.0); 4.2659 (1.2); 4.2543 (0.9); 4.2457 (0.8); 4.2265 (1.1); 4.2195 (1.0); 4.2050 (1.3); 4.1985 (0.8); 4.1836 (0.6); 4.1675 (0.5); 4.1527 (0.6); 4.1467 (0.5); 4.1318 (0.5); 3.8003 (0.4); 3.7906 (0.7); 3.7806 (1.1); 3.7709 (1.4); 3.7608 (1.2); 3.7502 (0.8); 3.7389 (0.4); 3.3617 (31.2); 3.1683 (2.1); 2.6743 (0.6); 2.6696 (0.8); 2.6650 (0.6); 2.6604 (0.4); 2.6315 (0.4); 2.6210 (0.5); 2.5958 (1.0); 2.5849 (1.4); 2.5742 (0.6); 2.5613 (1.1); 2.5507 (1.4); 2.5399 (1.2); 2.5232 (1.7); 2.5184 (2.7); 2.5098 (44.8); 2.5052 (98.6); 2.5006 (137.4); 2.4960 (99.7); 2.4914 (46.7); 2.4071 (0.5); 2.3998 (1.2); 2.3833 (0.8); 2.3784 (1.3); 2.3657 (2.0); 2.3447 (1.9); 2.3359 (1.4); 2.3322 (1.2); 2.3275 (1.3); 2.3229 (1.5); 2.3150 (1.1); 2.2934 (0.6); 2.2869 (0.5); 2.2786 (1.0); 2.2627 (1.1); 2.2540 (1.1); 2.2509 (1.1); 2.2412 (0.9); 2.2212 (0.5); 2.2096 (0.6); 2.1994 (0.5); 2.1249 (0.4); 2.1047 (0.9); 2.0927 (0.7); 2.0808 (0.9); 2.0723 (1.5); 2.0616 (0.5); 2.0524 (0.8); 2.0491 (0.9); 2.0295 (0.4); 1.8690 (0.6); 1.8571 (0.6); 1.8515 (0.7); 1.8399 (0.6); 1.8335 (0.5); 1.8224 (0.5); 1.8029 (0.6); 1.7945 (0.9); 1.7803 (1.0); 1.7709 (1.1); 1.7607 (1.1); 1.7533 (0.9); 1.7431 (0.8); 1.7294 (0.5); 1.3818 (0.5); 1.3644 (0.4); 1.3582 (0.3); 1.2949 (0.4); 1.2771 (0.6); 1.2600 (0.8); 1.2428 (0.9); 1.2249 (0.7); 1.2073 (0.4); 1.1887 (0.5); 1.1760 (0.5); 1.1694 (0.5); 1.1588 (0.8); 1.1540 (0.6); 1.1408 (0.9); 1.1354 (0.6); 1.1233 (0.7); 1.1066 (0.6); 1.0887 (0.4); 0.8483 (13.7); 0.8336 (16.0); 0.8313 (15.8); 0.8153 (4.9); 0.0082 (0.9) I.1-006: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3863 (1.5); 7.3823 (1.6); 7.3659 (3.0); 7.3617 (3.4); 7.3556 (1.7); 7.3461 (2.1); 7.3399 (3.3); 7.3357 (2.8); 7.3196 (1.8); 7.3156 (1.7); 7.2075 (1.8); 7.2037 (1.9); 7.1949 (1.9); 7.1911 (2.2); 7.1877 (3.4); 7.1840 (3.6); 7.1750 (3.4); 7.1715 (3.8); 7.1673 (2.3); 7.1635 (2.3); 7.1546 (2.0); 7.1512 (2.2); 7.1089 (3.6); 7.0930 (4.6); 7.0736 (2.3); 4.7514 (5.2); 4.7118 (6.0); 4.2748 (6.7); 4.2351 (5.7); 3.8544 (1.1); 3.8441 (2.1); 3.8339 (3.4); 3.8239 (4.0); 3.8138 (3.4); 3.8037 (2.6); 3.7930 (0.9); 3.4628 (15.4); 3.1689 (0.6); 2.8932 (5.3); 2.8829 (5.5); 2.8533 (7.2); 2.8431 (6.8); 2.6710 (0.5); 2.6664 (0.5); 2.6456 (7.4); 2.6245 (7.2); 2.6058 (5.8); 2.5847 (5.6); 2.5245 (1.2); 2.5197 (1.8); 2.5111 (30.4); 2.5065 (66.8); 2.5019 (93.7); 2.4972 (65.1); 2.4926 (28.7); 2.4590 (1.8); 2.4470 (4.5); 2.4406 (6.1); 2.4313 (9.6); 2.4180 (8.0); 2.4005 (3.4); 2.3949 (2.9); 2.3797 (1.5); 2.3648 (1.0); 2.3287 (0.6); 2.3004 (2.5); 2.2881 (2.8); 2.2758 (5.6); 2.2699 (7.5); 2.2637 (7.0); 2.2547 (10.3); 2.2383 (10.3); 2.2353 (10.2); 2.2289 (3.2); 2.2250 (4.9); 2.2156 (2.7); 2.2096 (2.1); 2.2045 (1.1); 2.1975 (3.3); 2.1912 (1.4); 2.1851 (1.1); 2.1782 (2.0); 2.1725 (1.8); 2.1537 (1.0); 2.0740 (3.4); 1.8160 (0.8); 1.7919 (3.1); 1.7803 (2.4); 1.7703 (2.8); 1.7626 (1.8); 1.7576 (1.8); 1.7535 (1.8); 1.7489 (2.0); 1.7381 (2.0); 1.7263 (1.3); 1.6501 (4.9); 1.5712 (13.8); 1.5641 (16.0); 1.5558 (11.3); -0.0002 (7.0) I.1-009: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.3860 (0.3); 7.3818 (0.4); 7.3654 (0.8); 7.3615 (0.8); 7.3556 (0.4); 7.3456 (0.5); 7.3395 (0.8); 7.3356 (0.7); 7.3192 (0.4); 7.3153 (0.4); 7.2123 (0.4); 7.2086 (0.4); 7.1996 (0.5); 7.1957 (0.6); 7.1924 (0.8); 7.1888 (0.9); 7.1796 (0.8); 7.1764 (0.9); 7.1723 (0.6); 7.1684 (0.6); 7.1595 (0.5); 7.1559 (0.5); 7.0953 (0.9); 7.0793 (1.2); 7.0764 (1.1); 7.0600 (0.6); 4.7406 (1.3); 4.7009 (1.6); 4.3621 (2.5); 4.3560 (0.6); 4.3474 (5.0); 4.3389 (0.7); 4.3328 (2.8); 4.2515 (1.7); 4.2119 (1.5); 3.8177 (0.5); 3.8073 (0.8); 3.7971 (0.9); 3.7872 (0.9); 3.7768 (0.6); 3.4789 (2.0); 3.4645 (3.4); 3.4499 (1.9); 3.3678 (10.0); 3.1687 (0.4); 2.9991 (16.0); 2.8276 (1.2); 2.8176 (1.2); 2.7875 (1.6); 2.7774 (1.5); 2.5588 (1.6); 2.5370 (1.6); 2.5186 (1.8); 2.5099 (10.4); 2.5053 (23.0); 2.5007 (32.8); 2.4962 (24.9); 2.4916 (11.6); 2.4522 (0.4); 2.4349 (0.5); 2.4113 (1.0); 2.3936 (0.8); 2.3878 (0.7); 2.3809 (0.3); 2.3722 (0.4); 2.2921 (0.6); 2.2798 (0.6); 2.2677 (1.1); 2.2554 (1.1); 2.2263 (1.8); 2.2161 (1.1); 2.2060 (0.6); 2.2003 (0.5); 2.1878 (0.8); 2.1817 (0.4); 2.1686 (0.5); 2.1629 (0.5); 1.7810 (0.7); 1.7697 (0.6); 1.7594 (0.8); 1.7516 (0.4); 1.7467 (0.4); 1.7421 (0.4); 1.7380 (0.5); 1.7269 (0.5); 0.0000 (9.4) I.1-011: 1H-NMR (400.1 MHz, d6-DMSO): δ= 19.7585 (0.3); 12.9496 (0.4); 12.6612 (0.4); 12.5714 (0.8); 12.5551 (0.6); 12.5285 (0.4); 8.1442 (0.6); 8.1255 (0.6); 8.1082 (0.4); 8.0797 (0.4); 8.0598 (1.4); 8.0365 (1.4); 7.9568 (0.6); 7.4617 (0.3); 7.3773 (0.7); 7.3549 (1.6); 7.3320 (1.6); 7.3094 (0.8); 7.2253 (0.4); 7.1847 (1.5); 7.1715 (1.6); 7.1543 (0.9); 7.0750 (1.9); 4.7539 (0.8); 4.7385 (1.7); 4.7121 (0.7); 4.6979 (1.9); 4.3971 (0.4); 4.3747 (0.4); 4.3452 (1.2); 4.3342 (1.3); 4.3244 (1.2); 4.3128 (1.1); 4.2488 (2.0); 4.2092 (2.0); 4.1683 (0.5); 4.1504 (0.6); 4.1304 (0.4); 4.0761 (0.6); 3.9659 (0.5); 3.9032 (0.3); 3.7811 (1.3); 3.7684 (1.7); 3.6533 (0.3); 3.6104 (0.4); 3.5831 (0.4); 3.5679 (0.5); 3.5390 (0.5); 3.5012 (0.6); 3.4888 (0.7); 3.4613 (0.8); 3.4216 (1.2); 3.3747 (2.8); 3.3178 (191.6); 3.2190 (1.5); 3.1907 (0.9); 3.1759 (2.8); 3.1633 (2.9); 3.1011 (0.3); 3.0923 (0.3); 3.0484 (0.3); 2.9989 (0.4); 2.8911 (4.6); 2.8794 (0.5); 2.8416 (0.4); 2.8290 (0.4); 2.7752 (0.4); 2.7315 (4.7); 2.6721 (3.3); 2.6460 (1.8); 2.6206 (2.3); 2.6130 (2.3); 2.5645 (2.6); 2.5030 (519.5); 2.3986 (2.3); 2.3764 (1.8); 2.3346 (4.2); 2.3020 (1.4); 2.2788 (1.8); 2.2605 (1.4); 2.2543 (1.4); 2.2229 (0.8); 2.1244 (0.5); 2.1025 (0.9); 2.0801 (1.2); 2.0721 (2.0); 2.0494 (1.0); 2.0274 (0.5); 1.8307 (1.2); 1.8156 (1.2); 1.7988 (1.3); 1.7776 (1.1); 1.7098 (0.3); 1.3822 (0.4); 1.3629 (0.4); 1.3493 (0.3); 1.2934 (0.5); 1.2783 (0.8); 1.2600 (0.9); 1.2433 (1.2); 1.2245 (0.8); 1.2092 (0.5); 1.1876 (0.4); 1.1534 (0.8); 1.1343 (1.1); 1.1167 (1.0); 1.0996 (0.8); 1.0820 (0.5); 0.8481 (12.7); 0.8318 (16.0); 0.8156 (4.6); 0.7823 (0.5); 0.1461 (0.5); 0.0081 (4.3); 0.0000 (107.5) I.1-012: 1H-NMR (400.1 MHz, CDCl3): δ= 7.2629 (13.1); 7.2610 (25.7); 7.1145 (0.4); 7.1026 (0.7); 7.0933 (0.4); 7.0853 (0.7); 7.0780 (0.8); 7.0739 (0.4); 7.0679 (0.4); 7.0594 (2.7); 7.0527 (1.5); 7.0491 (2.4); 7.0407 (0.9); 7.0354 (0.8); 4.8904 (1.0); 4.8871 (1.0); 4.8516 (1.2); 4.8483 (1.1); 4.2618 (1.5); 4.2230 (1.4); 3.9047 (0.5); 3.8944 (0.6); 3.8841 (0.8); 3.8736 (0.7); 3.8632 (0.5); 3.6680 (16.0); 2.7366 (1.0); 2.7264 (1.0); 2.6978 (1.3); 2.6875 (1.2); 2.5364 (0.3); 2.5119 (0.8); 2.4935 (0.7); 2.4877 (0.6); 2.4697 (0.6); 2.4376 (1.8); 2.4238 (0.8); 2.4152 (1.9); 2.3990 (1.8); 2.3765 (1.0); 2.3709 (0.5); 2.3570 (0.5); 2.3170 (0.4); 2.2989 (0.6); 2.2847 (0.4); 2.2793 (0.4); 2.2746 (0.4); 2.2664 (0.6); 2.2602 (0.4); 2.2466 (0.4); 2.2420 (0.4); 1.8760 (0.3); 1.8646 (0.5); 1.8519 (0.6); 1.8432 (0.5); 1.8407 (0.5); 1.8382 (0.4); 1.8320 (0.5); 1.8295 (0.4); 1.8268 (0.4); 1.8194 (0.5); 1.8080 (0.4); 1.5711 (5.5); 0.0019 (4.0) I.1-014: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.3682 (1.9); 7.3838 (3.5); 7.3798 (3.8); 7.3634 (7.2); 7.3593 (8.0); 7.3532 (4.1); 7.3437 (5.1); 7.3373 (7.7); 7.3332 (6.6); 7.3173 (4.4); 7.3133 (4.1); 7.2101 (4.5); 7.2062 (4.6); 7.1974 (4.6); 7.1935 (5.5); 7.1902 (8.2); 7.1864 (8.7); 7.1776 (7.9); 7.1739 (9.0); 7.1699 (5.4); 7.1659 (5.4); 7.1572 (4.6); 7.1536 (4.9); 7.0954 (8.4); 7.0793 (11.4); 7.0598 (5.7); 4.7429 (12.5); 4.7028 (14.4); 4.2543 (16.0); 4.2147 (14.0); 3.7888 (2.8); 3.7783 (5.0); 3.7671 (7.2); 3.7574 (7.7); 3.7472 (7.1); 3.7368 (5.5); 3.7262 (2.2); 3.3181 (83.5); 2.7049 (13.3); 2.6947 (13.5); 2.6746 (2.9); 2.6702 (4.7); 2.6651 (18.9); 2.6548 (16.1); 2.5405 (1.3); 2.5238 (9.2); 2.5190 (13.3); 2.5104 (196.8); 2.5058 (432.4); 2.5012 (604.9); 2.4966 (419.9); 2.4920 (185.2); 2.4464 (4.5); 2.4293 (4.4); 2.4193 (2.7); 2.4049 (10.6); 2.3995 (19.2); 2.3879 (7.9); 2.3775 (18.6); 2.3652 (4.6); 2.3597 (14.8); 2.3500 (2.2); 2.3376 (15.2); 2.3280 (3.7); 2.3233 (2.9); 2.2890 (6.6); 2.2760 (7.2); 2.2645 (11.7); 2.2516 (11.2); 2.2231 (9.7); 2.2201 (9.8); 2.2117 (6.8); 2.2061 (6.5); 2.1959 (6.1); 2.1902 (4.8); 2.1780 (7.5); 2.1716 (3.8); 2.1655 (2.7); 2.1587 (5.0); 2.1525 (4.2); 2.1339 (2.4); 2.0734 (1.2); 1.7825 (1.1); 1.7604 (3.2); 1.7549 (7.3); 1.7435 (7.2); 1.7304 (7.2); 1.7256 (4.2); 1.7199 (4.1); 1.7142 (4.8); 1.7011 (4.4); 1.6885 (2.8); 0.1457 (0.9); 0.0080 (9.3); -0.0002 (333.6); -0.0060 (3.4); -0.0085 (9.7); -0.0338 (0.9); -0.1498 (0.9) I.1-015: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.3621 (0.5); 7.3583 (0.6); 7.3425 (0.3); 7.3368 (0.6); 7.3325 (0.5); 7.1893 (0.6); 7.1858 (0.6); 7.1765 (0.6); 7.1734 (0.6); 7.1655 (0.4); 7.1532 (0.3); 7.0942 (0.6); 7.0781 (0.8); 7.0590 (0.4); 4.7306 (1.0); 4.6908 (1.1); 4.2636 (1.2); 4.2238 (1.0); 4.1134 (1.6); 4.1039 (1.7); 4.1016 (1.6); 4.0901 (1.9); 3.8187 (0.4); 3.8087 (0.6); 3.7985 (0.7); 3.7884 (0.6); 3.7783 (0.4); 3.5540 (0.3); 3.5057 (2.6); 3.4861 (3.3); 3.4809 (1.6); 3.4743 (2.9); 3.4628 (2.4); 3.2326 (16.0); 2.7929 (0.8); 2.7823 (0.8); 2.7530 (1.1); 2.7425 (1.1); 2.5512 (0.9); 2.5304 (1.2); 2.5235 (0.4); 2.5101 (7.8); 2.5055 (15.5); 2.5010 (21.5); 2.4965 (15.7); 2.4919 (8.0); 2.4384 (0.4); 2.4144 (0.7); 2.3970 (0.6); 2.3908 (0.5); 2.2923 (0.4); 2.2796 (0.4); 2.2678 (0.7); 2.2551 (0.8); 2.2254 (0.9); 2.2155 (0.7); 2.2116 (0.5); 2.2013 (0.4); 2.1957 (0.3); 2.1831 (0.5); 2.1583 (0.3); 1.7654 (0.5); 1.7542 (0.5); 1.7423 (0.6); 1.7247 (0.3); 1.7112 (0.4); 0.0007 (2.6); 0.0000 (2.7) I.1-016: 1H-NMR (400.1 MHz, d6-DMSO): δ= 8.1813 (0.9); 8.1602 (0.9); 8.1024 (1.2); 8.0802 (1.2); 7.3760 (0.5); 7.3547 (1.2); 7.3328 (1.2); 7.3097 (0.6); 7.2067 (0.6); 7.1869 (1.3); 7.1744 (1.3); 7.1667 (0.8); 7.1541 (0.7); 7.0897 (1.0); 7.0739 (1.6); 7.0585 (0.8); 4.7547 (1.7); 4.7150 (2.0); 4.3988 (1.1); 4.3873 (1.2); 4.3766 (1.1); 4.3651 (1.2); 4.2672 (1.4); 4.2557 (1.1); 4.2276 (1.3); 4.2211 (1.3); 4.2168 (1.1); 4.2064 (1.2); 4.2000 (1.0); 4.1852 (0.9); 3.8011 (0.8); 3.7919 (1.1); 3.7826 (1.5); 3.7725 (1.8); 3.7626 (1.7); 3.7523 (1.4); 3.7412 (1.0); 2.5966 (0.9); 2.5858 (1.4); 2.5752 (0.7); 2.5624 (1.1); 2.5514 (1.9); 2.5408 (1.0); 2.5237 (0.4); 2.5190 (0.6); 2.5103 (12.4); 2.5058 (27.8); 2.5012 (39.6); 2.4966 (28.8); 2.4920 (13.8); 2.4567 (0.3); 2.4078 (0.6); 2.4012 (1.2); 2.3845 (0.9); 2.3799 (1.3); 2.3668 (2.2); 2.3461 (2.2); 2.3374 (1.0); 2.3236 (1.2); 2.3161 (0.8); 2.2785 (0.7); 2.2759 (0.7); 2.2656 (0.8); 2.2631 (0.8); 2.2546 (1.0); 2.2515 (0.9); 2.2415 (1.0); 2.2386 (1.0); 2.2241 (0.5); 2.2213 (0.4); 2.2128 (0.6); 2.2098 (0.5); 2.1999 (0.6); 2.1260 (0.4); 2.1058 (0.8); 2.0942 (0.6); 2.0849 (0.7); 2.0823 (0.7); 2.0745 (1.0); 2.0722 (1.1); 2.0625 (0.4); 2.0538 (0.8); 1.8697 (0.6); 1.8581 (0.6); 1.8523 (0.6); 1.8407 (0.6); 1.8353 (0.4); 1.8232 (0.4); 1.8097 (0.4); 1.8056 (0.5); 1.7966 (0.8); 1.7862 (0.8); 1.7827 (0.9); 1.7729 (1.1); 1.7633 (1.1); 1.7552 (1.0); 1.7517 (0.9); 1.7445 (0.8); 1.7408 (0.8); 1.7295 (0.5); 1.3826 (0.4); 1.3785 (0.4); 1.3672 (0.4); 1.3594 (0.4); 1.3490 (0.3); 1.2969 (0.3); 1.2789 (0.6); 1.2620 (0.7); 1.2446 (0.8); 1.2266 (0.6); 1.2107 (0.4); 1.1928 (0.4); 1.1893 (0.4); 1.1774 (0.4); 1.1705 (0.5); 1.1596 (0.8); 1.1416 (1.0); 1.1238 (0.8); 1.1074 (0.6); 1.0894 (0.4); 0.8493 (11.9); 0.8343 (16.0); 0.8161 (4.9) I.1-017: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3831 (2.0); 7.3792 (2.1); 7.3627 (4.0); 7.3586 (4.4); 7.3526 (2.3); 7.3429 (2.8); 7.3368 (4.3); 7.3325 (3.7); 7.3164 (2.3); 7.3124 (2.1); 7.2081 (2.6); 7.2041 (2.7); 7.1954 (2.6); 7.1914 (3.1); 7.1882 (4.6); 7.1844 (4.9); 7.1755 (4.5); 7.1719 (5.0); 7.1678 (3.0); 7.1638 (2.9); 7.1551 (2.5); 7.1514 (2.9); 7.0874 (4.7); 7.0715 (6.3); 7.0680 (5.7); 7.0520 (3.2); 6.1735 (0.9); 5.0416 (1.8); 5.0346 (3.7); 5.0254 (4.3); 5.0185 (5.9); 5.0117 (3.6); 5.0032 (3.4); 4.7163 (7.1); 4.6765 (8.3); 4.2594 (9.4); 4.2195 (8.0); 3.8187 (1.7); 3.8077 (3.2); 3.7985 (4.4); 3.7878 (6.2); 3.7778 (4.0); 3.7679 (3.4); 3.7570 (1.4); 3.5345 (16.0); 3.1684 (3.0); 2.7094 (7.7); 2.6986 (7.9); 2.6699 (12.2); 2.6591 (10.5); 2.6003 (0.5); 2.5956 (0.5); 2.5612 (0.8); 2.5567 (1.2); 2.5521 (1.3); 2.5474 (0.6); 2.5237 (2.5); 2.5189 (3.8); 2.5103 (67.7); 2.5057 (147.2); 2.5010 (206.5); 2.4964 (148.4); 2.4918 (69.8); 2.4738 (11.6); 2.4544 (6.4); 2.4344 (9.9); 2.4166 (2.2); 2.4078 (1.4); 2.3927 (5.3); 2.3751 (4.3); 2.3691 (3.8); 2.3532 (2.6); 2.3370 (0.6); 2.3325 (1.5); 2.3279 (1.4); 2.3232 (1.0); 2.2980 (3.9); 2.2846 (4.5); 2.2735 (6.8); 2.2602 (6.8); 2.2442 (0.7); 2.2320 (4.4); 2.2239 (6.7); 2.2200 (3.4); 2.2109 (2.9); 2.2080 (3.6); 2.1973 (3.5); 2.1914 (2.7); 2.1866 (1.6); 2.1834 (1.9); 2.1796 (3.9); 2.1728 (2.2); 2.1669 (1.6); 2.1598 (2.7); 2.1533 (2.4); 2.1353 (1.5); 2.0727 (1.1); 1.8271 (0.8); 1.8115 (2.1); 1.8020 (3.0); 1.7880 (5.5); 1.7768 (5.5); 1.7727 (5.8); 1.7651 (5.0); 1.7568 (7.5); 1.7451 (6.3); 1.7380 (3.6); 1.7340 (4.1); 1.7323 (4.1); 1.7287 (3.8); 1.7209 (2.7); 1.7144 (3.9); 1.7025 (2.6); 1.6892 (1.7); 1.6451 (0.6); 1.6320 (1.0); 1.6262 (1.4); 1.6152 (2.6); 1.6037 (4.2); 1.5947 (6.5); 1.5857 (4.9); 1.5832 (4.9); 1.5796 (4.5); 1.5732 (5.5); 1.5667 (4.3); 1.5637 (5.0); 1.5548 (7.4); 1.5442 (12.8); 1.5355 (8.9); 1.5300 (10.2); 1.5219 (9.2); 1.5174 (10.4); 1.5125 (9.2); 1.5072 (7.5); 1.5010 (5.7); 1.4967 (4.2); 1.4877 (2.7); 1.1950 (0.5); 1.1769 (1.1); 1.1586 (0.5); 0.0080 (1.4); -0.0002 (55.1); - 0.0085 (1.7) I.1-020: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3835 (0.9); 7.3794 (0.9); 7.3630 (1.8); 7.3589 (2.0); 7.3529 (1.0); 7.3432 (1.2); 7.3370 (2.0); 7.3328 (1.7); 7.3168 (1.1); 7.3128 (1.0); 7.2114 (1.1); 7.2074 (1.2); 7.1987 (1.1); 7.1948 (1.3); 7.1915 (2.1); 7.1877 (2.2); 7.1788 (2.0); 7.1752 (2.2); 7.1711 (1.4); 7.1672 (1.4); 7.1584 (1.2); 7.1547 (1.3); 7.0971 (2.1); 7.0812 (2.8); 7.0777 (2.6); 7.0617 (1.5); 4.7325 (3.2); 4.6928 (3.8); 4.2733 (4.2); 4.2335 (3.6); 3.8378 (1.0); 3.8304 (15.1); 3.8123 (16.0); 3.7975 (2.0); 3.7873 (1.6); 3.7765 (0.6); 3.3106 (98.6); 3.2828 (0.6); 2.7797 (3.3); 2.7690 (3.3); 2.7400 (4.6); 2.7293 (4.4); 2.6700 (0.6); 2.5511 (0.6); 2.5454 (4.9); 2.5247 (5.3); 2.5189 (2.0); 2.5102 (31.1); 2.5056 (70.4); 2.5010 (92.7); 2.4963 (64.7); 2.4917 (29.4); 2.4852 (4.8); 2.4754 (0.5); 2.4569 (1.3); 2.4391 (0.9); 2.4295 (0.5); 2.4157 (2.4); 2.3983 (1.8); 2.3922 (1.6); 2.3836 (0.7); 2.3765 (0.8); 2.3278 (0.6); 2.2981 (1.7); 2.2853 (1.8); 2.2736 (3.0); 2.2609 (2.9); 2.2316 (3.5); 2.2219 (2.6); 2.2181 (1.9); 2.2084 (1.6); 2.2027 (1.3); 2.1976 (0.6); 2.1908 (1.9); 2.1838 (1.0); 2.1781 (0.7); 2.1712 (1.2); 2.1648 (1.0); 2.1466 (0.6); 2.0725 (0.6); 1.7778 (0.8); 1.7739 (1.9); 1.7628 (1.8); 1.7552 (1.2); 1.7513 (2.0); 1.7446 (1.1); 1.7391 (1.1); 1.7341 (1.2); 1.7314 (1.1); 1.7200 (1.2); 1.7075 (0.8); 1.0693 (0.6); 1.0629 (0.8); 1.0509 (1.6); 1.0494 (1.5); 1.0428 (1.4); 1.0391 (1.1); 1.0310 (3.0); 1.0229 (1.1); 1.0190 (1.5); 1.0126 (1.5); 1.0110 (1.8); 0.9991 (1.0); 0.9927 (0.7); 0.5139 (2.1); 0.5032 (6.3); 0.4987 (7.1); 0.4939 (2.8); 0.4881 (3.0); 0.4828 (7.2); 0.4785 (6.0); 0.4681 (2.6); 0.2467 (2.6); 0.2362 (7.3); 0.2322 (6.8); 0.2244 (6.2); 0.2205 (7.8); 0.2097 (1.8); -0.0002 (9.9) I.1-021: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3662 (0.7); 7.3621 (0.8); 7.3404 (0.8); 7.3360 (0.7); 7.1942 (0.5); 7.1909 (0.8); 7.1872 (0.8); 7.1782 (0.8); 7.1747 (0.9); 7.1706 (0.5); 7.1667 (0.5); 7.0968 (0.8); 7.0808 (1.1); 7.0775 (1.0); 7.0613 (0.6); 5.9130 (0.5); 5.8992 (1.1); 5.8866 (0.7); 5.8730 (1.3); 5.8700 (0.7); 5.8593 (0.6); 5.8561 (1.4); 5.8434 (0.8); 5.8427 (0.8); 5.8299 (1.4); 5.8162 (0.6); 5.3003 (0.7); 5.2962 (2.1); 5.2921 (2.2); 5.2880 (0.8); 5.2572 (0.6); 5.2531 (1.8); 5.2490 (1.9); 5.2449 (0.7); 5.2206 (0.8); 5.2172 (1.9); 5.2133 (1.8); 5.2099 (0.7); 5.1944 (0.7); 5.1910 (1.7); 5.1871 (1.7); 5.1837 (0.6); 4.7275 (1.2); 4.6877 (1.5); 4.5180 (2.3); 4.5143 (4.0); 4.5107 (2.4); 4.5042 (2.3); 4.5006 (3.9); 4.4969 (2.3); 4.2703 (1.6); 4.2305 (1.4); 3.8294 (0.5); 3.8192 (0.8); 3.8091 (1.0); 3.7991 (0.8); 3.7888 (0.6); 3.4612 (16.0); 2.8291 (1.3); 2.8185 (1.3); 2.7890 (1.7); 2.7784 (1.6); 2.5812 (1.8); 2.5602 (1.8); 2.5411 (1.4); 2.5202 (1.8); 2.5122 (10.8); 2.5077 (23.1); 2.5030 (31.8); 2.4984 (22.5); 2.4939 (10.3); 2.4157 (1.0); 2.3981 (0.8); 2.3922 (0.7); 2.2979 (0.6); 2.2852 (0.7); 2.2734 (1.2); 2.2607 (1.1); 2.2302 (1.1); 2.2277 (1.0); 2.2207 (0.8); 2.2161 (0.7); 2.2060 (0.6); 2.1881 (0.8); 1.7633 (0.7); 1.7522 (0.7); 1.7396 (0.8); -0.0002 (3.0) I.1-022: 1H-NMR (400.1 MHz, d6-DMSO): δ= 12.4106 (0.4); 12.3700 (0.4); 12.3632 (0.5); 12.3444 (0.5); 12.3338 (0.5); 12.3240 (0.5); 7.3860 (4.9); 7.3663 (13.8); 7.3481 (16.0); 7.3415 (7.3); 7.3370 (13.8); 7.3328 (10.6); 7.3217 (2.6); 7.3166 (5.1); 7.3129 (3.4); 7.2944 (15.5); 7.2037 (10.0); 7.1858 (8.1); 4.6615 (9.8); 4.6225 (11.4); 4.1613 (11.3); 4.1223 (9.8); 3.7632 (1.6); 3.7525 (3.3); 3.7417 (4.7); 3.7323 (4.8); 3.7212 (4.6); 3.7107 (3.7); 3.7001 (1.9); 3.4494 (1.5); 3.1704 (0.4); 2.7033 (7.3); 2.6934 (7.5); 2.6636 (9.3); 2.6536 (8.9); 2.5235 (0.6); 2.5101 (23.3); 2.5056 (51.5); 2.5011 (73.1); 2.4965 (53.5); 2.4920 (26.0); 2.4604 (0.4); 2.4502 (2.4); 2.4416 (0.7); 2.4324 (2.6); 2.4253 (2.6); 2.4084 (5.8); 2.3907 (4.5); 2.3846 (4.2); 2.3676 (4.0); 2.3419 (9.4); 2.3329 (1.0); 2.3193 (9.3); 2.3108 (4.5); 2.3022 (8.3); 2.2970 (5.3); 2.2864 (6.6); 2.2796 (8.3); 2.2725 (6.7); 2.2559 (1.7); 2.2447 (3.7); 2.2317 (4.1); 2.2152 (2.8); 2.1969 (3.5); 2.1911 (1.8); 2.1845 (3.1); 2.1790 (2.7); 2.1723 (2.6); 2.1661 (4.1); 2.1603 (2.6); 2.1547 (1.8); 2.1471 (2.7); 2.1412 (2.8); 2.1228 (1.6); 2.0720 (2.4); 1.7470 (2.0); 1.7350 (3.3); 1.7235 (4.1); 1.7160 (2.6); 1.7124 (3.3); 1.7041 (3.8); 1.6991 (2.6); 1.6919 (3.8); 1.6805 (2.5); 1.6672 (1.7) I.1-023: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5210 (0.4); 7.3865 (5.6); 7.3669 (8.7); 7.3136 (4.4); 7.2954 (8.2); 7.2754 (4.8); 7.2620 (76.5); 7.2333 (3.1); 7.2148 (4.0); 7.1968 (1.3); 7.1220 (0.5); 7.1099 (1.0); 7.0976 (1.9); 7.0867 (1.3); 7.0799 (1.9); 7.0718 (2.2); 7.0511 (5.0); 7.0477 (5.1); 7.0383 (6.7); 7.0281 (3.3); 7.0099 (0.4); 6.9980 (0.5); 4.8708 (3.2); 4.8318 (3.5); 4.2556 (5.6); 4.2388 (16.0); 4.2218 (6.2); 4.2007 (3.9); 3.8722 (0.6); 3.8621 (1.2); 3.8512 (1.9); 3.8409 (2.3); 3.8306 (2.0); 3.8198 (1.4); 3.8096 (0.7); 3.1305 (6.0); 3.1136 (12.0); 3.0967 (5.8); 2.6841 (2.6); 2.6742 (2.7); 2.6453 (3.3); 2.6353 (3.4); 2.5356 (0.7); 2.5178 (0.9); 2.5119 (0.9); 2.4930 (2.2); 2.4744 (1.9); 2.4692 (2.0); 2.4509 (1.8); 2.4237 (1.7); 2.4092 (1.9); 2.3992 (2.4); 2.3848 (2.6); 2.3779 (4.0); 2.3667 (1.0); 2.3558 (4.4); 2.3390 (3.1); 2.3168 (2.6); 2.2951 (1.0); 2.2760 (1.5); 2.2716 (1.0); 2.2628 (1.2); 2.2577 (1.1); 2.2517 (1.2); 2.2433 (1.7); 2.2387 (1.2); 2.2333 (0.8); 2.2246 (1.0); 2.2189 (1.3); 2.2002 (0.6); 1.8500 (0.8); 1.8371 (1.3); 1.8255 (1.5); 1.8155 (1.5); 1.8043 (1.4); 1.7931 (1.4); 1.7810 (1.0); 1.7679 (0.7); 1.5958 (37.9); 1.2550 (0.5) I.1-024: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3813 (0.9); 7.3773 (1.0); 7.3609 (1.9); 7.3568 (2.1); 7.3507 (1.1); 7.3411 (1.3); 7.3351 (2.1); 7.3307 (1.8); 7.3147 (1.1); 7.3106 (1.1); 7.2095 (1.2); 7.2055 (1.3); 7.1968 (1.2); 7.1929 (1.4); 7.1896 (2.2); 7.1858 (2.4); 7.1769 (2.2); 7.1733 (2.4); 7.1693 (1.5); 7.1653 (1.5); 7.1565 (1.3); 7.1529 (1.4); 7.0992 (2.2); 7.0834 (2.9); 7.0798 (2.7); 7.0639 (1.5); 4.7341 (3.2); 4.6941 (3.9); 4.6676 (15.7); 4.6668 (15.5); 4.6615 (15.9); 4.6606 (15.6); 4.2611 (4.4); 4.2213 (3.8); 4.0208 (1.0); 4.0031 (1.0); 3.8310 (0.9); 3.8206 (1.6); 3.8102 (2.4); 3.8001 (2.7); 3.7900 (2.4); 3.7797 (1.9); 3.7694 (1.0); 3.6357 (7.1); 3.5480 (7.2); 3.5418 (16.0); 3.5357 (6.8); 3.1674 (2.2); 2.8446 (3.4); 2.8344 (3.4); 2.8044 (4.6); 2.7942 (4.3); 2.6744 (0.7); 2.6698 (1.0); 2.6651 (0.8); 2.5908 (4.9); 2.5695 (4.8); 2.5507 (4.1); 2.5458 (0.6); 2.5400 (0.8); 2.5293 (4.0); 2.5233 (2.6); 2.5186 (3.5); 2.5099 (49.2); 2.5053 (105.4); 2.5007 (146.4); 2.4960 (102.8); 2.4915 (46.3); 2.4757 (0.6); 2.4646 (1.1); 2.4477 (1.1); 2.4385 (0.7); 2.4236 (2.5); 2.4059 (2.2); 2.4007 (2.0); 2.3922 (0.8); 2.3846 (1.0); 2.3692 (0.6); 2.3322 (0.8); 2.3275 (1.0); 2.3228 (0.7); 2.2919 (1.7); 2.2796 (1.8); 2.2673 (3.1); 2.2551 (3.1); 2.2259 (4.6); 2.2167 (2.7); 2.2137 (2.3); 2.2040 (1.8); 2.1980 (1.4); 2.1929 (0.8); 2.1859 (2.2); 2.1794 (1.1); 2.1734 (0.8); 2.1665 (1.4); 2.1606 (1.3); 2.1419 (0.8); 2.0720 (1.0); 1.7875 (0.5); 1.7619 (2.0); 1.7506 (1.6); 1.7399 (2.3); 1.7326 (1.2); 1.7276 (1.2); 1.7229 (1.2); 1.7186 (1.3); 1.7081 (1.3); 1.6960 (0.9); 1.1543 (1.3); 1.1365 (2.6); 1.1187 (1.2); 0.0080 (0.6); - 0.0002 (22.9); -0.0085 (0.6) I.1-025: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3828 (2.8); 7.3788 (3.0); 7.3623 (5.7); 7.3582 (6.3); 7.3522 (3.3); 7.3425 (4.0); 7.3363 (6.2); 7.3321 (5.4); 7.3160 (3.4); 7.3121 (3.3); 7.2091 (3.6); 7.2051 (3.8); 7.1964 (3.8); 7.1924 (4.4); 7.1892 (6.6); 7.1854 (7.0); 7.1765 (6.5); 7.1729 (7.2); 7.1689 (4.4); 7.1649 (4.2); 7.1561 (3.7); 7.1524 (4.0); 7.0886 (6.8); 7.0727 (9.1); 7.0692 (8.3); 7.0531 (4.7); 4.8884 (2.2); 4.8863 (2.3); 4.8687 (8.7); 4.8510 (12.0); 4.8490 (12.2); 4.8313 (8.8); 4.8137 (2.3); 4.8114 (2.2); 4.7146 (10.2); 4.6748 (12.1); 4.2630 (13.4); 4.2231 (11.4); 3.8305 (0.9); 3.8233 (2.4); 3.8124 (5.2); 3.8029 (6.4); 3.7924 (8.6); 3.7825 (5.8); 3.7724 (4.7); 3.7616 (1.9); 3.3641 (1.6); 3.3429 (0.8); 3.3388 (1.2); 3.3339 (2.4); 3.3147 (672.4); 3.2910 (17.4); 3.2631 (0.7); 3.1761 (0.6); 3.1629 (0.6); 2.7359 (10.9); 2.7251 (11.0); 2.6960 (15.2); 2.6852 (14.5); 2.6749 (1.3); 2.6703 (1.5); 2.6657 (1.0); 2.5459 (0.8); 2.5405 (1.1); 2.5238 (3.8); 2.5191 (5.7); 2.5105 (82.5); 2.5058 (163.7); 2.5012 (225.8); 2.4966 (159.3); 2.4919 (85.2); 2.4797 (1.4); 2.4720 (11.9); 2.4516 (11.4); 2.4408 (3.1); 2.4316 (0.9); 2.4234 (3.5); 2.4141 (2.2); 2.3997 (7.8); 2.3821 (6.1); 2.3762 (5.5); 2.3650 (2.5); 2.3600 (2.9); 2.3435 (1.2); 2.3374 (0.6); 2.3326 (1.2); 2.3280 (1.8); 2.3234 (1.1); 2.3188 (0.5); 2.2958 (5.5); 2.2827 (6.1); 2.2712 (9.9); 2.2630 (5.6); 2.2582 (11.2); 2.2486 (4.3); 2.2450 (5.7); 2.2428 (7.6); 2.2385 (9.3); 2.2365 (9.1); 2.2323 (11.8); 2.2301 (13.6); 2.2255 (15.7); 2.2185 (15.1); 2.2145 (13.2); 2.2125 (16.0); 2.2081 (9.3); 2.2059 (8.0); 2.2024 (9.7); 2.1947 (8.7); 2.1880 (8.2); 2.1847 (6.8); 2.1781 (3.3); 2.1721 (2.3); 2.1651 (4.1); 2.1588 (3.5); 2.1405 (2.1); 2.0724 (0.7); 1.9896 (0.6); 1.9858 (2.2); 1.9800 (1.4); 1.9770 (2.7); 1.9700 (2.1); 1.9663 (3.1); 1.9608 (6.7); 1.9572 (4.7); 1.9551 (5.1); 1.9522 (7.9); 1.9452 (5.4); 1.9413 (6.6); 1.9359 (8.2); 1.9327 (9.2); 1.9302 (8.0); 1.9272 (8.3); 1.9214 (5.6); 1.9171 (5.3); 1.9106 (7.0); 1.9079 (6.8); 1.9058 (5.4); 1.9022 (5.4); 1.8967 (3.1); 1.8931 (2.2); 1.8859 (3.3); 1.8806 (1.1); 1.8773 (2.3); 1.8733 (0.6); 1.7838 (1.0); 1.7620 (2.9); 1.7562 (7.6); 1.7515 (3.9); 1.7492 (3.8); 1.7450 (7.9); 1.7374 (4.3); 1.7315 (9.9); 1.7269 (8.7); 1.7246 (9.8); 1.7219 (7.6); 1.7178 (5.8); 1.7155 (6.7); 1.7092 (2.9); 1.7067 (5.1); 1.7023 (7.0); 1.7000 (10.3); 1.6976 (7.2); 1.6932 (4.5); 1.6905 (4.8); 1.6821 (1.6); 1.6797 (1.6); 1.6753 (2.5); 1.6729 (2.5); 1.6685 (1.3); 1.6661 (1.2); 1.6268 (3.0); 1.6068 (5.3); 1.6018 (5.8); 1.5866 (3.4); 1.5816 (11.1); 1.5766 (4.0); 1.5749 (5.1); 1.5615 (5.5); 1.5597 (3.6); 1.5564 (6.0); 1.5547 (8.5); 1.5497 (2.4); 1.5362 (2.9); 1.5345 (3.9); 1.5295 (3.2); 1.5093 (1.5); 0.0079 (0.6); -0.0002 (19.9); -0.0085 (0.5) I.1-026: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3625 (1.0); 7.3584 (1.1); 7.3524 (0.6); 7.3427 (0.7); 7.3365 (1.0); 7.3324 (0.9); 7.3162 (0.6); 7.3123 (0.6); 7.2101 (0.6); 7.2061 (0.6); 7.1974 (0.6); 7.1934 (0.7); 7.1901 (1.1); 7.1863 (1.2); 7.1775 (1.1); 7.1738 (1.2); 7.1698 (0.8); 7.1658 (0.7); 7.1570 (0.6); 7.1533 (0.7); 7.0898 (1.1); 7.0739 (1.6); 7.0704 (1.4); 7.0544 (0.8); 4.8813 (0.9); 4.8657 (2.5); 4.8500 (3.5); 4.8344 (2.6); 4.8187 (1.0); 4.7207 (1.7); 4.6810 (2.0); 4.2640 (2.3); 4.2241 (1.9); 3.8189 (0.8); 3.8094 (1.1); 3.7989 (1.5); 3.7888 (1.0); 3.7789 (0.8); 3.4236 (20.1); 3.1686 (1.0); 2.7196 (2.0); 2.7088 (2.0); 2.6801 (2.8); 2.6749 (0.5); 2.6694 (2.8); 2.5237 (0.7); 2.5190 (1.1); 2.5104 (19.1); 2.5058 (41.5); 2.5012 (57.3); 2.4965 (40.0); 2.4919 (18.4); 2.4689 (2.9); 2.4498 (2.1); 2.4294 (2.1); 2.4242 (0.7); 2.4000 (1.4); 2.3821 (1.0); 2.3762 (0.9); 2.3599 (0.5); 2.2992 (1.0); 2.2859 (1.1); 2.2746 (1.7); 2.2615 (1.6); 2.2332 (1.2); 2.2292 (1.3); 2.2270 (1.3); 2.2216 (0.9); 2.2179 (0.8); 2.2145 (1.0); 2.2042 (0.9); 2.1984 (0.7); 2.1866 (1.0); 2.1797 (0.6); 2.1669 (0.7); 2.1603 (0.6); 1.7586 (1.1); 1.7473 (1.1); 1.7400 (0.6); 1.7339 (1.0); 1.7292 (0.6); 1.7233 (0.6); 1.7173 (0.8); 1.7047 (0.6); 1.1496 (16.0); 1.1465 (15.9); 1.1340 (15.8); 1.1309 (15.9); -0.0002 (1.0) I.1-027: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3813 (1.0); 7.3609 (2.1); 7.3383 (2.1); 7.3352 (2.0); 7.3147 (1.1); 7.2100 (1.1); 7.2064 (1.2); 7.1973 (1.2); 7.1898 (2.2); 7.1866 (2.3); 7.1770 (2.1); 7.1740 (2.4); 7.1661 (1.3); 7.1570 (1.1); 7.1536 (1.3); 7.0890 (2.3); 7.0730 (3.1); 7.0537 (1.5); 5.7926 (0.9); 5.7759 (1.9); 5.7670 (0.9); 5.7592 (0.9); 5.7501 (2.8); 5.7330 (2.8); 5.7239 (1.0); 5.7161 (1.0); 5.7072 (2.2); 5.6904 (1.0); 5.1063 (1.3); 5.1023 (3.2); 5.0974 (3.7); 5.0935 (1.5); 5.0632 (1.2); 5.0593 (2.9); 5.0543 (3.6); 5.0500 (4.2); 5.0470 (2.2); 5.0448 (2.8); 5.0418 (1.3); 5.0273 (1.4); 5.0242 (3.1); 5.0213 (2.0); 5.0192 (2.6); 5.0161 (1.1); 4.8686 (1.1); 4.8508 (1.5); 4.8488 (1.5); 4.8311 (1.1); 4.7250 (2.4); 4.7144 (1.3); 4.6854 (2.8); 4.6742 (1.6); 4.2566 (3.5); 4.2167 (3.0); 4.0464 (5.8); 4.0299 (13.0); 4.0134 (6.4); 3.8183 (0.8); 3.8119 (1.0); 3.8074 (1.4); 3.7976 (2.0); 3.7919 (1.8); 3.7874 (2.5); 3.7818 (1.5); 3.7774 (1.9); 3.7721 (1.3); 3.7673 (1.5); 3.7609 (0.8); 3.7568 (0.8); 3.5904 (16.0); 3.1680 (2.5); 2.7609 (2.4); 2.7502 (2.5); 2.7355 (1.3); 2.7245 (1.7); 2.7211 (3.5); 2.7105 (3.3); 2.6956 (2.0); 2.6848 (1.8); 2.6746 (0.7); 2.6700 (1.0); 2.6653 (0.8); 2.6000 (0.5); 2.5234 (2.1); 2.5206 (4.7); 2.5102 (54.9); 2.5056 (118.5); 2.5009 (165.6); 2.4963 (114.3); 2.4917 (53.2); 2.4810 (3.6); 2.4718 (1.4); 2.4601 (2.8); 2.4549 (1.3); 2.4507 (3.1); 2.4455 (2.5); 2.4415 (2.1); 2.4249 (1.4); 2.4164 (1.1); 2.4074 (0.8); 2.4011 (2.6); 2.3834 (2.0); 2.3790 (1.9); 2.3612 (1.2); 2.3324 (0.8); 2.3277 (1.0); 2.3230 (0.8); 2.3140 (1.2); 2.3105 (1.9); 2.3071 (1.2); 2.2974 (3.8); 2.2939 (7.0); 2.2906 (4.0); 2.2807 (4.9); 2.2774 (6.1); 2.2739 (3.8); 2.2686 (3.0); 2.2640 (1.8); 2.2606 (2.6); 2.2561 (3.7); 2.2428 (1.1); 2.2385 (1.3); 2.2365 (1.2); 2.2322 (1.5); 2.2267 (3.2); 2.2189 (3.7); 2.2152 (2.7); 2.2124 (2.4); 2.2076 (2.1); 2.1941 (2.1); 2.1878 (2.0); 2.1830 (1.4); 2.1758 (1.7); 2.1691 (1.0); 2.1642 (1.0); 2.1562 (1.2); 2.1499 (1.0); 2.1316 (0.6); 2.0721 (1.2); 1.9607 (0.8); 1.9549 (0.6); 1.9521 (1.0); 1.9451 (0.7); 1.9412 (0.8); 1.9358 (1.0); 1.9325 (1.1); 1.9301 (1.0); 1.9271 (1.0); 1.9213 (0.7); 1.9170 (0.7); 1.9104 (0.9); 1.9077 (0.8); 1.9021 (0.7); 1.7623 (1.0); 1.7553 (2.1); 1.7492 (0.7); 1.7437 (2.2); 1.7315 (2.4); 1.7270 (2.0); 1.7248 (2.1); 1.7200 (1.5); 1.7131 (1.7); 1.7067 (0.8); 1.7001 (2.2); 1.6932 (0.7); 1.6882 (0.9); 1.6067 (0.7); 1.6017 (0.7); 1.5815 (1.4); 1.5748 (0.6); 1.5614 (0.7); 1.5546 (1.1); 1.5345 (0.5); 0.0080 (0.6); 0.0023 (0.7); -0.0002 (20.5); -0.0085 (0.6) I.1-028: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5188 (1.2); 7.3157 (1.4); 7.3097 (10.2); 7.3076 (4.4); 7.3043 (3.9); 7.2974 (2.1); 7.2913 (14.0); 7.2879 (13.8); 7.2820 (2.6); 7.2781 (1.3); 7.2745 (5.0); 7.2715 (6.0); 7.2694 (14.2); 7.2668 (3.9); 7.2659 (4.2); 7.2600 (208.0); 7.2535 (3.8); 7.2526 (3.2); 7.2510 (2.2); 7.2501 (1.9); 7.2493 (1.7); 7.2485 (1.5); 7.2476 (1.3); 7.2468 (1.3); 7.2461 (1.1); 7.2452 (1.0); 7.2444 (0.9); 7.2436 (0.9); 7.2428 (0.8); 7.2420 (0.7); 7.2411 (0.7); 7.2403 (0.7); 7.2395 (0.6); 7.2387 (0.5); 7.2379 (0.4); 7.2370 (0.4); 7.2362 (0.4); 7.2354 (0.4); 7.2338 (0.3); 7.1133 (1.1); 7.1030 (1.4); 7.0982 (1.9); 7.0957 (1.3); 7.0882 (3.6); 7.0783 (2.6); 7.0703 (4.1); 7.0641 (4.0); 7.0590 (4.0); 7.0472 (15.9); 7.0374 (15.1); 7.0324 (4.4); 7.0289 (5.9); 7.0220 (4.1); 7.0132 (0.6); 7.0025 (0.8); 6.9951 (3.3); 6.9925 (5.8); 6.9898 (3.5); 6.9762 (4.2); 6.9741 (9.8); 6.9720 (4.8); 6.9583 (2.5); 6.9556 (4.6); 6.9530 (2.7); 6.9098 (2.0); 6.9079 (2.4); 6.9044 (12.8); 6.9017 (16.0); 6.8997 (8.1); 6.8964 (4.4); 6.8874 (4.3); 6.8850 (7.2); 6.8824 (13.8); 6.8799 (11.8); 6.8735 (1.5); 4.8834 (4.9); 4.8796 (5.0); 4.8446 (5.6); 4.8407 (5.7); 4.4396 (9.1); 4.4333 (4.3); 4.4286 (10.7); 4.4247 (8.2); 4.4219 (4.6); 4.4161 (13.5); 4.2610 (8.0); 4.2221 (7.2); 4.1668 (14.2); 4.1617 (4.4); 4.1577 (8.4); 4.1548 (13.8); 4.1490 (4.2); 4.1434 (11.6); 3.9179 (1.2); 3.9070 (2.3); 3.8965 (3.4); 3.8861 (3.9); 3.8759 (3.4); 3.8655 (2.5); 3.8548 (1.3); 3.6679 (9.8); 3.4895 (0.4); 2.7731 (5.7); 2.7630 (5.8); 2.7342 (7.5); 2.7241 (7.3); 2.6981 (0.7); 2.6876 (0.7); 2.5477 (1.2); 2.5460 (1.2); 2.5299 (1.6); 2.5281 (1.6); 2.5234 (1.5); 2.5215 (1.5); 2.5048 (3.7); 2.4853 (3.6); 2.4802 (10.6); 2.4583 (8.3); 2.4412 (6.4); 2.4225 (4.3); 2.4194 (6.8); 2.4144 (1.9); 2.4082 (4.0); 2.3980 (5.6); 2.3837 (5.1); 2.3799 (2.2); 2.3759 (1.0); 2.3712 (0.5); 2.3656 (1.5); 2.3551 (2.8); 2.3412 (2.8); 2.3045 (2.2); 2.2850 (2.7); 2.2801 (1.7); 2.2723 (2.6); 2.2671 (2.2); 2.2605 (2.1); 2.2542 (3.0); 2.2526 (2.8); 2.2477 (2.1); 2.2427 (1.5); 2.2344 (2.1); 2.2279 (2.1); 2.2099 (1.4); 2.1326 (1.7); 2.0912 (2.6); 2.0041 (1.3); 1.8820 (1.8); 1.8707 (2.0); 1.8684 (2.3); 1.8575 (2.9); 1.8496 (2.3); 1.8469 (2.4); 1.8440 (2.2); 1.8380 (2.2); 1.8359 (2.4); 1.8326 (2.1); 1.8246 (2.5); 1.8140 (1.7); 1.8113 (1.6); 1.7997 (1.4); 1.5592 (12.2); 1.4369 (0.9); 1.4227 (0.9); 1.2845 (0.6); 1.2554 (2.0); 0.8800 (0.4); 0.8456 (0.4); 0.8358 (0.5); 0.0081 (1.1); 0.0061 (0.6); 0.0000 (36.6) I.1-029: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3630 (0.9); 7.3589 (1.0); 7.3528 (0.5); 7.3432 (0.6); 7.3370 (1.0); 7.3328 (0.9); 7.3168 (0.5); 7.3127 (0.5); 7.2091 (0.6); 7.2051 (0.6); 7.1964 (0.6); 7.1924 (0.7); 7.1892 (1.1); 7.1854 (1.1); 7.1765 (1.0); 7.1729 (1.2); 7.1688 (0.7); 7.1648 (0.7); 7.1561 (0.6); 7.1524 (0.6); 7.0919 (1.0); 7.0756 (1.4); 7.0566 (0.7); 4.8077 (0.5); 4.8010 (0.7); 4.7920 (0.8); 4.7897 (0.7); 4.7870 (0.7); 4.7846 (0.8); 4.7780 (0.7); 4.7757 (0.7); 4.7690 (0.5); 4.7311 (1.6); 4.6913 (1.9); 4.2601 (1.6); 4.2202 (1.3); 3.8119 (0.7); 3.8021 (1.0); 3.7918 (1.3); 3.7818 (1.0); 3.7717 (0.7); 3.4307 (10.7); 3.1680 (0.7); 2.7543 (1.0); 2.7474 (1.0); 2.7437 (1.1); 2.7369 (1.0); 2.7149 (1.3); 2.7080 (1.4); 2.7043 (1.3); 2.6976 (1.2); 2.5500 (0.6); 2.5454 (0.6); 2.5403 (0.6); 2.5236 (0.9); 2.5188 (1.2); 2.5102 (17.0); 2.5056 (36.3); 2.5010 (50.3); 2.4963 (35.4); 2.4918 (16.7); 2.4781 (1.4); 2.4717 (1.2); 2.4594 (0.8); 2.4533 (0.6); 2.4388 (1.3); 2.4322 (1.2); 2.4222 (0.5); 2.4061 (0.7); 2.3989 (0.6); 2.3815 (0.9); 2.3010 (0.6); 2.2881 (0.7); 2.2775 (1.0); 2.2761 (1.0); 2.2632 (1.2); 2.2347 (0.7); 2.2280 (1.4); 2.2153 (0.6); 2.2124 (0.8); 2.2018 (0.8); 2.1961 (0.6); 2.1838 (0.8); 2.1644 (0.6); 2.1581 (0.5); 1.7478 (0.7); 1.7456 (0.6); 1.7339 (0.8); 1.7233 (0.6); 1.7176 (0.8); 1.7034 (0.7); 1.4766 (0.6); 1.4665 (0.5); 1.4625 (0.8); 1.4575 (0.9); 1.4531 (0.8); 1.4480 (0.8); 1.4433 (1.1); 1.4389 (1.0); 1.4347 (0.9); 1.4307 (0.8); 1.4246 (1.1); 1.4203 (1.0); 1.4169 (0.6); 1.4118 (0.9); 1.4089 (0.9); 1.4049 (0.7); 1.3954 (0.7); 1.3912 (0.8); 1.2861 (0.6); 1.2757 (0.6); 1.2723 (0.7); 1.2675 (0.7); 1.2639 (0.9); 1.2574 (0.9); 1.2537 (0.9); 1.2489 (0.9); 1.2456 (0.9); 1.2395 (1.1); 1.2351 (0.8); 1.2309 (1.0); 1.2218 (1.0); 1.2133 (0.7); 1.2056 (0.5); 1.1247 (8.4); 1.1178 (8.5); 1.1091 (8.4); 1.1021 (8.4); 0.8641 (7.1); 0.8458 (16.0); 0.8275 (5.8); -0.0002 (12.0) I.1-031: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3833 (0.6); 7.3793 (0.6); 7.3629 (1.2); 7.3588 (1.4); 7.3527 (0.7); 7.3431 (0.9); 7.3370 (1.3); 7.3327 (1.2); 7.3166 (0.7); 7.3126 (0.7); 7.2098 (0.8); 7.2059 (0.8); 7.1972 (0.8); 7.1932 (0.9); 7.1899 (1.4); 7.1862 (1.5); 7.1773 (1.4); 7.1736 (1.5); 7.1696 (0.9); 7.1656 (0.9); 7.1569 (0.8); 7.1532 (0.9); 7.0943 (1.3); 7.0781 (1.8); 7.0598 (0.9); 4.7399 (1.6); 4.7332 (2.7); 4.7247 (2.0); 4.7173 (1.9); 4.7090 (1.9); 4.7014 (2.3); 4.6935 (3.0); 4.6861 (1.1); 4.2622 (2.8); 4.2224 (2.4); 3.8145 (0.9); 3.8046 (1.4); 3.7943 (1.7); 3.7843 (1.3); 3.7741 (1.0); 3.4668 (16.0); 3.1680 (1.2); 2.7597 (1.3); 2.7546 (1.4); 2.7492 (1.4); 2.7442 (1.3); 2.7203 (1.8); 2.7154 (1.8); 2.7098 (1.8); 2.7049 (1.7); 2.5235 (1.2); 2.5188 (1.7); 2.5102 (28.0); 2.5056 (61.7); 2.5010 (84.6); 2.4963 (57.8); 2.4917 (26.1); 2.4843 (2.6); 2.4798 (2.1); 2.4657 (1.5); 2.4613 (1.4); 2.4449 (1.5); 2.4404 (1.7); 2.4231 (0.6); 2.4066 (0.9); 2.3999 (0.9); 2.3890 (0.7); 2.3825 (1.2); 2.3766 (0.7); 2.3656 (0.6); 2.3278 (0.6); 2.3000 (0.8); 2.2868 (0.9); 2.2775 (1.3); 2.2753 (1.3); 2.2623 (1.5); 2.2338 (1.0); 2.2292 (1.7); 2.2177 (1.0); 2.2144 (1.1); 2.2039 (1.1); 2.1982 (0.8); 2.1865 (1.2); 2.1794 (0.7); 2.1667 (0.8); 2.1601 (0.7); 2.0722 (0.5); 1.7639 (0.7); 1.7531 (1.2); 1.7420 (1.2); 1.7348 (0.8); 1.7288 (0.9); 1.7232 (0.8); 1.7112 (0.8); 1.6975 (0.6); 1.5145 (1.1); 1.4958 (4.0); 1.4799 (4.5); 1.4773 (4.7); 1.4614 (4.4); 1.4429 (1.4); 1.1223 (12.5); 1.1159 (12.5); 1.1066 (12.4); 1.1002 (12.4); 0.8300 (5.2); 0.8261 (5.2); 0.8115 (11.2); 0.8076 (11.2); 0.7927 (4.8); 0.7889 (4.7); -0.0002 (15.5) I.1-032: 1H-NMR (400.1 MHz, CDCl3): δ= 7.2680 (0.4); 7.2603 (39.0); 7.0907 (0.4); 7.0728 (0.5); 7.0665 (0.5); 7.0597 (0.6); 7.0495 (1.9); 7.0401 (1.8); 7.0350 (0.6); 7.0316 (0.6); 7.0245 (0.4); 6.8313 (16.0); 4.8857 (0.6); 4.8816 (0.6); 4.8469 (0.7); 4.8429 (0.6); 4.4111 (1.0); 4.3996 (1.1); 4.3963 (0.8); 4.3876 (1.4); 4.2610 (1.0); 4.2222 (0.9); 4.1134 (1.5); 4.1081 (0.4); 4.1043 (0.9); 4.1015 (1.4); 4.0958 (0.4); 4.0900 (1.2); 3.8992 (0.4); 3.8890 (0.4); 3.8787 (0.4); 3.7686 (12.8); 3.6680 (2.6); 2.7755 (0.6); 2.7654 (0.6); 2.7366 (0.9); 2.7264 (0.9); 2.5062 (0.4); 2.4847 (1.1); 2.4629 (1.1); 2.4458 (0.7); 2.4240 (1.1); 2.4143 (0.4); 2.4098 (0.4); 2.3995 (0.7); 2.3852 (0.6); 2.3567 (0.4); 2.2548 (0.3); 1.8604 (0.4); 1.5522 (4.2) I.1-034: 1H-NMR (400.1 MHz, CDCl3): δ= 7.9307 (12.0); 7.9106 (13.3); 7.9065 (7.9); 7.7014 (2.1); 7.6982 (2.3); 7.6848 (4.4); 7.6802 (6.4); 7.6747 (1.8); 7.6642 (4.7); 7.6610 (4.7); 7.6578 (2.1); 7.6051 (9.0); 7.6002 (3.2); 7.5875 (11.4); 7.5846 (11.3); 7.5701 (4.4); 7.5664 (5.0); 7.5194 (1.0); 7.3621 (0.5); 7.3183 (0.7); 7.2675 (73.0); 7.2657 (73.4); 7.2606 (172.6); 7.2381 (0.6); 7.2185 (0.6); 7.1331 (1.1); 7.1262 (1.1); 7.1152 (3.0); 7.1090 (2.9); 7.0960 (4.3); 7.0900 (3.3); 7.0840 (3.7); 7.0784 (3.4); 7.0729 (3.1); 7.0658 (5.5); 7.0595 (7.1); 7.0479 (11.7); 7.0394 (9.2); 7.0351 (7.8); 7.0161 (1.3); 6.9966 (1.0); 4.8916 (1.1); 4.8402 (5.6); 4.8014 (6.3); 4.4350 (8.1); 4.4201 (16.0); 4.4050 (8.5); 4.2634 (1.3); 4.2238 (1.2); 4.1828 (6.4); 4.1441 (5.7); 3.8839 (0.9); 3.8741 (0.6); 3.8633 (0.4); 3.8159 (1.0); 3.8053 (1.9); 3.7944 (3.0); 3.7845 (3.4); 3.7739 (2.9); 3.7632 (2.0); 3.7530 (1.0); 3.6747 (5.3); 3.6682 (11.4); 3.4911 (0.6); 3.4383 (9.0); 3.4238 (15.1); 3.4084 (8.1); 2.7371 (0.8); 2.7271 (0.8); 2.6983 (1.0); 2.6883 (0.9); 2.5468 (3.9); 2.5370 (4.0); 2.5127 (4.2); 2.5074 (5.4); 2.4974 (6.1); 2.4704 (3.8); 2.4512 (4.1); 2.4462 (3.1); 2.4369 (1.8); 2.4278 (3.3); 2.4151 (4.2); 2.4002 (4.5); 2.3908 (3.6); 2.3764 (4.9); 2.3577 (1.4); 2.3480 (1.7); 2.3337 (1.6); 2.3168 (0.4); 2.2990 (0.6); 2.2761 (1.7); 2.2475 (6.5); 2.2384 (2.4); 2.2318 (4.7); 2.2255 (7.8); 2.2196 (2.3); 2.2078 (5.4); 2.2011 (2.2); 2.1861 (4.3); 2.1339 (1.2); 2.1014 (1.6); 2.0945 (3.8); 2.0048 (1.0); 1.8647 (0.5); 1.8514 (0.5); 1.8429 (0.6); 1.8325 (0.6); 1.8194 (0.4); 1.8083 (0.3); 1.7845 (1.3); 1.7731 (1.9); 1.7603 (2.4); 1.7517 (2.5); 1.7405 (2.4); 1.7280 (1.9); 1.7163 (1.6); 1.7021 (1.0); 1.6582 (0.3); 1.5562 (20.6); 1.4778 (0.4); 1.4380 (0.7); 1.4236 (0.9); 1.3335 (0.9); 1.3206 (0.6); 1.3094 (0.8); 1.2847 (1.6); 1.2607 (3.9); 1.1827 (0.4); 1.0873 (0.3); 1.0523 (0.4); 0.9215 (0.3); 0.8948 (0.7); 0.8820 (1.2); 0.8531 (2.0); 0.8367 (2.2); 0.0154 (0.4); 0.0069 (12.3); 0.0051 (12.5); 0.0000 (29.8) I.1-035: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5192 (0.9); 7.2837 (0.4); 7.2828 (0.4); 7.2820 (0.4); 7.2812 (0.4); 7.2804 (0.5); 7.2797 (0.4); 7.2771 (0.7); 7.2763 (0.7); 7.2755 (0.8); 7.2747 (0.9); 7.2730 (1.2); 7.2722 (1.4); 7.2605 (167.0); 7.2517 (16.6); 7.2460 (5.3); 7.2402 (1.2); 7.2347 (5.7); 7.2290 (17.3); 7.2205 (1.7); 7.2102 (1.3); 7.1613 (0.3); 7.1173 (0.7); 7.1074 (0.7); 7.1024 (1.4); 7.0923 (2.2); 7.0825 (1.5); 7.0744 (2.7); 7.0681 (2.5); 7.0624 (2.1); 7.0594 (2.0); 7.0520 (9.4); 7.0507 (8.9); 7.0420 (9.5); 7.0369 (3.0); 7.0336 (3.7); 7.0265 (2.6); 7.0176 (0.4); 7.0071 (0.4); 6.9965 (0.9); 6.8412 (1.8); 6.8326 (16.0); 6.8269 (4.7); 6.8156 (4.9); 6.8099 (14.2); 6.8013 (1.3); 4.8846 (3.2); 4.8806 (3.0); 4.8458 (3.6); 4.8418 (3.4); 4.4266 (6.6); 4.4206 (3.1); 4.4151 (7.4); 4.4118 (5.0); 4.4085 (3.1); 4.4031 (8.3); 4.2569 (4.6); 4.2181 (4.2); 4.1316 (8.6); 4.1263 (3.1); 4.1227 (5.5); 4.1197 (8.2); 4.1138 (2.8); 4.1082 (7.0); 3.9164 (0.8); 3.9057 (1.5); 3.8954 (2.2); 3.8850 (2.7); 3.8747 (2.2); 3.8643 (1.6); 3.8538 (0.8); 3.6681 (7.0); 2.7712 (3.5); 2.7611 (3.5); 2.7323 (4.7); 2.7221 (4.5); 2.6982 (0.5); 2.6879 (0.5); 2.5475 (0.7); 2.5295 (1.0); 2.5276 (1.0); 2.5232 (0.9); 2.5211 (0.8); 2.5047 (2.4); 2.4927 (5.4); 2.4866 (2.3); 2.4804 (2.0); 2.4787 (2.0); 2.4712 (5.1); 2.4624 (2.0); 2.4537 (4.0); 2.4364 (1.1); 2.4322 (4.0); 2.4259 (2.4); 2.4116 (2.6); 2.4013 (3.3); 2.3871 (3.2); 2.3831 (1.3); 2.3759 (0.7); 2.3690 (1.0); 2.3584 (1.8); 2.3445 (1.7); 2.3043 (1.3); 2.2848 (1.8); 2.2798 (1.2); 2.2720 (1.7); 2.2667 (1.5); 2.2602 (1.4); 2.2539 (1.8); 2.2522 (1.8); 2.2474 (1.5); 2.2423 (1.0); 2.2340 (1.4); 2.2293 (1.2); 2.2276 (1.3); 2.2094 (0.8); 2.1335 (1.4); 2.0926 (1.2); 2.0047 (1.0); 1.8813 (1.1); 1.8701 (1.3); 1.8676 (1.4); 1.8569 (1.8); 1.8490 (1.4); 1.8462 (1.6); 1.8433 (1.5); 1.8375 (1.5); 1.8350 (1.5); 1.8319 (1.4); 1.8238 (1.6); 1.8134 (1.1); 1.8106 (1.0); 1.7990 (0.9); 1.5557 (14.2); 1.4376 (0.7); 1.4234 (0.7); 1.2846 (0.4); 1.2552 (1.1); 0.8362 (0.3); 0.8313 (0.3); 0.0082 (1.0) I.1-036: 1H-NMR (400.1 MHz, CDCl3): δ= 7.2694 (0.4); 7.2686 (0.4); 7.2600 (56.2); 7.1138 (0.4); 7.0988 (0.9); 7.0919 (3.4); 7.0903 (4.1); 7.0890 (3.6); 7.0757 (1.6); 7.0702 (5.4); 7.0687 (4.6); 7.0644 (2.0); 7.0590 (1.6); 7.0468 (5.0); 7.0369 (4.6); 7.0323 (1.5); 7.0286 (1.8); 7.0218 (1.3); 6.9961 (0.4); 6.8046 (0.6); 6.7972 (5.5); 6.7920 (1.9); 6.7809 (1.6); 6.7757 (4.9); 6.7684 (0.6); 4.8815 (1.4); 4.8778 (1.5); 4.8428 (1.6); 4.8390 (1.7); 4.4208 (2.8); 4.4145 (1.3); 4.4093 (3.2); 4.4061 (2.4); 4.4035 (1.5); 4.3974 (3.9); 4.2584 (2.3); 4.2196 (2.1); 4.1333 (3.9); 4.1280 (1.4); 4.1242 (2.4); 4.1213 (3.9); 4.1157 (1.4); 4.1098 (3.3); 3.9158 (0.4); 3.9050 (0.7); 3.8946 (1.0); 3.8841 (1.2); 3.8738 (1.1); 3.8633 (0.8); 3.8527 (0.4); 3.6678 (2.8); 2.7717 (1.6); 2.7616 (1.7); 2.7328 (2.1); 2.7227 (2.1); 2.5438 (0.4); 2.5262 (0.5); 2.5212 (0.4); 2.5191 (0.4); 2.5015 (1.1); 2.4828 (1.0); 2.4766 (3.1); 2.4593 (1.0); 2.4547 (2.3); 2.4377 (2.0); 2.4196 (1.2); 2.4158 (2.0); 2.4053 (1.2); 2.3951 (1.6); 2.3808 (1.5); 2.3769 (0.7); 2.3628 (0.5); 2.3523 (0.8); 2.3383 (0.9); 2.3013 (0.7); 2.2848 (16.0); 2.2690 (1.0); 2.2640 (0.8); 2.2574 (0.7); 2.2494 (0.9); 2.2444 (0.6); 2.2395 (0.5); 2.2312 (0.6); 2.2247 (0.6); 2.2066 (0.4); 2.1320 (0.4); 2.0040 (0.4); 1.8792 (0.5); 1.8678 (0.6); 1.8654 (0.7); 1.8546 (0.8); 1.8467 (0.6); 1.8440 (0.7); 1.8412 (0.7); 1.8354 (0.6); 1.8330 (0.7); 1.8297 (0.6); 1.8217 (0.7); 1.8112 (0.5); 1.8084 (0.5); 1.7969 (0.4); 1.5619 (6.3); 1.2553 (0.5) I.1-038: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3803 (0.5); 7.3639 (1.0); 7.3598 (1.1); 7.3537 (0.6); 7.3440 (0.7); 7.3380 (1.1); 7.3336 (1.0); 7.3176 (0.6); 7.3136 (0.6); 7.2100 (0.6); 7.2061 (0.7); 7.1973 (0.6); 7.1935 (0.8); 7.1902 (1.2); 7.1864 (1.3); 7.1775 (1.2); 7.1739 (1.3); 7.1698 (0.8); 7.1659 (0.8); 7.1571 (0.7); 7.1534 (0.8); 7.0994 (1.2); 7.0832 (1.6); 7.0639 (0.8); 4.7475 (1.3); 4.7079 (1.5); 4.6399 (1.2); 4.6290 (1.3); 4.6253 (1.5); 4.6144 (1.4); 4.6133 (1.4); 4.6096 (1.3); 4.5988 (1.2); 4.2576 (2.2); 4.2179 (1.9); 3.8070 (0.8); 3.7968 (1.2); 3.7868 (1.4); 3.7766 (1.1); 3.7664 (0.8); 3.4183 (25.7); 3.1677 (1.0); 2.7849 (1.0); 2.7745 (1.1); 2.7689 (1.1); 2.7587 (1.1); 2.7456 (1.4); 2.7352 (1.4); 2.7298 (1.4); 2.7197 (1.3); 2.6699 (0.6); 2.5233 (1.1); 2.5186 (1.7); 2.5100 (30.5); 2.5054 (66.0); 2.5007 (92.6); 2.4961 (65.3); 2.4915 (30.8); 2.4810 (2.2); 2.4741 (1.6); 2.4629 (1.4); 2.4530 (1.6); 2.4417 (1.4); 2.4248 (0.6); 2.4107 (0.8); 2.4001 (0.8); 2.3929 (0.6); 2.3841 (0.8); 2.3758 (0.6); 2.3275 (0.6); 2.3028 (0.6); 2.2999 (0.6); 2.2890 (0.7); 2.2866 (0.7); 2.2783 (1.0); 2.2751 (1.0); 2.2645 (1.1); 2.2620 (1.2); 2.2367 (0.7); 2.2337 (0.7); 2.2269 (1.7); 2.2135 (0.8); 2.2107 (0.9); 2.1999 (0.9); 2.1942 (0.7); 2.1859 (0.5); 2.1823 (1.0); 2.1754 (0.6); 2.1625 (0.7); 2.1562 (0.6); 1.7676 (0.5); 1.7565 (0.8); 1.7484 (0.8); 1.7373 (1.0); 1.7298 (0.6); 1.7254 (1.3); 1.7227 (1.5); 1.7123 (0.8); 1.7056 (2.1); 1.6912 (1.8); 1.6886 (1.4); 1.6741 (1.2); 1.0775 (10.2); 1.0693 (10.3); 1.0616 (10.3); 1.0533 (10.1); 0.8384 (8.8); 0.8341 (16.0); 0.8316 (10.6); 0.8214 (8.8); 0.8171 (15.3); 0.8146 (10.4); 0.0079 (0.6); 0.0021 (0.8); -0.0002 (21.6); -0.0027 (1.2); -0.0085 (0.7) I.1-039: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9822 (0.9); 8.9751 (2.5); 8.9723 (2.4); 8.5699 (1.0); 8.5500 (1.0); 7.3976 (2.7); 7.3588 (0.8); 7.3362 (0.8); 7.1830 (0.8); 7.1703 (0.9); 7.0676 (0.7); 7.0480 (1.1); 7.0319 (0.6); 4.7177 (1.0); 4.6788 (1.3); 4.6586 (0.6); 4.6454 (0.6); 4.6384 (0.6); 4.1850 (1.2); 4.1450 (1.0); 3.7248 (0.7); 3.7144 (0.8); 3.7040 (0.7); 3.6433 (16.0); 3.6323 (5.2); 3.4005 (43.8); 3.1683 (1.9); 3.1533 (0.7); 3.1285 (0.9); 3.1152 (0.9); 3.0044 (0.9); 2.9808 (0.9); 2.9666 (0.7); 2.9433 (0.6); 2.6701 (0.7); 2.6654 (0.5); 2.5634 (0.8); 2.5523 (0.8); 2.5278 (1.3); 2.5236 (1.7); 2.5187 (2.7); 2.5102 (38.1); 2.5056 (83.0); 2.5010 (116.5); 2.4964 (81.0); 2.4918 (36.4); 2.3371 (0.6); 2.3326 (0.7); 2.3278 (0.8); 2.3231 (0.6); 2.3166 (0.8); 2.2955 (1.0); 2.2733 (0.7); 2.2567 (0.8); 2.2417 (1.4); 2.2323 (1.0); 2.2193 (1.7); 2.2058 (1.0); 2.2009 (0.7); 2.1845 (0.8); 2.0105 (0.5); 1.9785 (0.5); -0.0002 (1.4) I.1-040: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5939 (0.3); 7.5408 (0.4); 7.5191 (1.0); 7.3295 (0.7); 7.3245 (5.0); 7.3186 (2.4); 7.3138 (0.4); 7.3083 (3.6); 7.3021 (16.0); 7.2973 (3.2); 7.2914 (0.7); 7.2869 (3.2); 7.2816 (16.7); 7.2759 (3.9); 7.2727 (1.0); 7.2719 (1.0); 7.2711 (1.0); 7.2703 (0.9); 7.2694 (1.0); 7.2686 (1.1); 7.2654 (4.2); 7.2645 (4.0); 7.2604 (153.4); 7.2553 (3.7); 7.2545 (3.1); 7.2537 (2.3); 7.2528 (1.9); 7.2520 (1.7); 7.2512 (1.5); 7.2504 (1.3); 7.2495 (1.1); 7.2487 (1.0); 7.2479 (0.8); 7.2471 (0.8); 7.2463 (0.7); 7.2454 (0.6); 7.2446 (0.6); 7.2438 (0.5); 7.2430 (0.5); 7.2422 (0.4); 7.2414 (0.4); 7.2405 (0.4); 7.2397 (0.4); 7.2389 (0.3); 7.2381 (0.3); 7.1274 (0.5); 7.1146 (1.2); 7.1098 (0.6); 7.1025 (2.2); 7.0917 (1.1); 7.0845 (1.9); 7.0777 (2.3); 7.0738 (1.2); 7.0673 (1.2); 7.0588 (7.1); 7.0524 (3.9); 7.0471 (6.2); 7.0399 (2.4); 7.0347 (2.8); 7.0275 (0.5); 6.9964 (0.8); 4.8845 (2.5); 4.8805 (2.5); 4.8457 (2.8); 4.8417 (2.7); 4.2610 (0.4); 4.2428 (3.8); 4.2360 (6.6); 4.2190 (13.7); 4.2022 (8.9); 3.8803 (0.6); 3.8696 (1.1); 3.8591 (1.7); 3.8489 (1.9); 3.8383 (1.6); 3.8279 (1.2); 3.8174 (0.6); 3.6680 (4.6); 3.1049 (6.9); 3.0880 (14.1); 3.0710 (6.5); 2.7004 (2.8); 2.6903 (2.8); 2.6615 (3.6); 2.6513 (3.4); 2.5420 (0.6); 2.5239 (0.7); 2.5193 (0.7); 2.4997 (1.8); 2.4809 (1.5); 2.4765 (1.4); 2.4576 (1.5); 2.4367 (0.6); 2.4311 (1.8); 2.4241 (0.4); 2.4165 (2.2); 2.4065 (2.7); 2.4019 (4.1); 2.3922 (2.6); 2.3882 (1.1); 2.3802 (3.8); 2.3739 (1.0); 2.3631 (4.0); 2.3495 (1.4); 2.3412 (2.9); 2.3002 (1.1); 2.2809 (1.3); 2.2760 (0.8); 2.2678 (1.2); 2.2625 (1.0); 2.2564 (1.0); 2.2482 (1.4); 2.2432 (1.1); 2.2381 (0.7); 2.2298 (1.0); 2.2237 (1.1); 2.2052 (0.6); 2.0945 (2.9); 2.0048 (0.9); 1.8549 (0.9); 1.8435 (1.0); 1.8410 (1.2); 1.8301 (1.4); 1.8222 (1.0); 1.8197 (1.2); 1.8170 (1.1); 1.8109 (1.0); 1.8083 (1.1); 1.8054 (1.0); 1.7971 (1.2); 1.7870 (0.8); 1.7842 (0.7); 1.7725 (0.7); 1.5518 (8.7); 1.2555 (1.0); 0.0083 (0.8); 0.0059 (0.4); 0.0051 (0.4); 0.0043 (0.6); 0.0034 (0.8); 0.0025 (1.4) I.1-041: 1H-NMR (400.1 MHz, d6-DMSO): δ= 16.4145 (0.6); 16.2990 (0.6); 16.2499 (0.6); 13.9263 (0.6); 12.3927 (0.6); 12.3615 (0.9); 12.3469 (1.7); 12.3246 (9.3); 12.2694 (0.6); 8.0558 (0.6); 7.6338 (1.2); 7.4203 (6.3); 7.3990 (13.3); 7.3933 (7.1); 7.3779 (8.1); 7.3720 (13.5); 7.3508 (7.1); 7.3073 (5.7); 7.3022 (6.1); 7.2877 (6.1); 7.2824 (6.9); 7.2732 (6.5); 7.2589 (5.6); 7.2535 (5.9); 7.1008 (6.3); 7.0960 (6.2); 7.0915 (6.5); 7.0862 (6.5); 7.0800 (5.9); 4.6385 (0.6); 4.6242 (12.7); 4.5855 (14.4); 4.2602 (0.6); 4.2387 (0.8); 4.2237 (0.6); 4.1570 (16.0); 4.1184 (13.8); 3.7772 (8.5); 3.7675 (2.8); 3.7564 (4.8); 3.7457 (7.3); 3.7356 (7.4); 3.7256 (6.9); 3.7149 (5.5); 3.7041 (2.4); 3.6002 (0.6); 3.5093 (1.4); 3.4927 (1.0); 3.4465 (2.0); 3.4404 (2.0); 3.4278 (1.9); 3.4105 (2.2); 3.3184 (45.5); 3.1684 (1.6); 3.1444 (0.9); 3.1291 (0.7); 3.1143 (0.7); 3.0862 (7.0); 3.0544 (0.6); 3.0413 (0.6); 2.6916 (11.1); 2.6815 (11.6); 2.6745 (2.3); 2.6695 (2.5); 2.6647 (1.9); 2.6518 (14.1); 2.6417 (13.3); 2.6128 (0.6); 2.5984 (0.7); 2.5785 (0.7); 2.5577 (0.6); 2.5097 (120.2); 2.5051 (262.8); 2.5006 (368.2); 2.4960 (264.0); 2.4915 (123.8); 2.4397 (3.2); 2.4224 (4.0); 2.4159 (3.6); 2.3985 (9.0); 2.3805 (7.2); 2.3741 (6.4); 2.3577 (6.2); 2.3456 (14.0); 2.3323 (2.4); 2.3233 (15.1); 2.3055 (15.7); 2.2906 (7.3); 2.2833 (13.9); 2.2663 (9.6); 2.2499 (2.0); 2.2385 (5.7); 2.2258 (6.2); 2.2160 (4.3); 2.1980 (5.4); 2.1922 (2.6); 2.1861 (4.9); 2.1808 (4.0); 2.1731 (3.6); 2.1689 (5.8); 2.1621 (3.7); 2.1566 (2.4); 2.1491 (4.0); 2.1440 (3.9); 2.1246 (2.2); 2.0715 (1.5); 1.7418 (3.1); 1.7305 (5.2); 1.7191 (6.1); 1.7084 (5.0); 1.7004 (5.9); 1.6947 (3.8); 1.6878 (5.5); 1.6764 (4.0); 1.6623 (2.6); 1.3037 (0.6); 1.2668 (0.7); 1.2345 (3.6); 1.1852 (0.7); 1.1780 (0.7); 1.1595 (0.8); 1.1415 (0.6); 1.1247 (0.7); 0.8675 (0.9); 0.8546 (0.8); 0.8281 (0.7); 0.8099 (0.7); 0.0081 (3.1) I.1-042: 1H-NMR (400.1 MHz, CDCl3): δ= 8.0105 (0.4); 7.9829 (0.5); 7.9140 (0.4); 7.7961 (0.4); 7.6100 (0.4); 7.5591 (0.4); 7.5306 (0.5); 7.5191 (0.9); 7.4864 (0.6); 7.4556 (0.4); 7.4145 (0.9); 7.3816 (8.9); 7.3636 (12.6); 7.3494 (1.2); 7.3163 (6.0); 7.2981 (12.8); 7.2795 (7.3); 7.2602 (120.3); 7.2396 (1.4); 7.2365 (1.1); 7.2227 (1.9); 7.2103 (0.8); 7.2065 (0.7); 7.2036 (1.1); 7.2001 (0.6); 7.1777 (2.6); 7.1529 (0.4); 7.1455 (1.4); 7.1288 (1.3); 7.1087 (4.8); 7.0835 (3.8); 7.0627 (2.6); 7.0478 (3.3); 7.0266 (1.6); 6.9965 (0.6); 6.9481 (3.0); 6.6665 (0.3); 4.7604 (5.3); 4.7221 (5.7); 4.2513 (7.6); 4.2344 (14.9); 4.2176 (6.9); 4.1329 (0.4); 4.0809 (6.3); 4.0427 (5.4); 3.8732 (1.1); 3.8612 (2.0); 3.8514 (2.7); 3.8409 (3.7); 3.8307 (2.6); 3.8205 (1.8); 3.8093 (0.6); 3.4900 (0.4); 3.1239 (8.7); 3.1071 (16.0); 3.0905 (6.8); 3.0246 (0.4); 2.5803 (3.6); 2.5691 (3.4); 2.5412 (4.8); 2.5302 (5.3); 2.5105 (2.9); 2.4917 (2.7); 2.4684 (2.3); 2.4458 (2.2); 2.4314 (2.5); 2.4214 (3.1); 2.4069 (3.3); 2.3882 (0.8); 2.3785 (1.3); 2.3640 (1.4); 2.3304 (4.5); 2.3094 (4.4); 2.2913 (3.6); 2.2705 (4.4); 2.2627 (1.5); 2.2520 (1.6); 2.2432 (2.1); 2.2192 (1.5); 2.1988 (0.6); 2.0040 (0.5); 1.8394 (1.2); 1.8275 (1.9); 1.8147 (2.0); 1.8036 (2.1); 1.7917 (2.0); 1.7826 (1.7); 1.7707 (1.2); 1.7566 (0.7); 1.6507 (0.6); 1.5618 (20.4); 1.4781 (0.6); 1.4433 (0.4); 1.2579 (0.4); 0.0886 (0.3); 0.0000 (19.6) I.1-044: 1H-NMR (400.1 MHz, d6-DMSO): δ= 18.4071 (0.6); 14.1020 (0.4); 12.3265 (5.4); 10.2103 (0.4); 8.6838 (0.4); 8.6715 (0.5); 7.6579 (2.6); 7.4492 (0.7); 7.4449 (0.7); 7.4205 (5.8); 7.3994 (12.0); 7.3937 (6.4); 7.3782 (7.0); 7.3724 (11.9); 7.3512 (6.6); 7.3071 (5.4); 7.3023 (5.7); 7.2879 (5.6); 7.2789 (6.6); 7.2735 (5.7); 7.2586 (5.4); 7.2534 (5.3); 7.1306 (0.5); 7.1017 (6.0); 7.0913 (6.1); 7.0864 (6.5); 7.0814 (5.6); 5.0716 (0.5); 4.6239 (12.5); 4.5851 (14.8); 4.2367 (0.6); 4.2230 (0.8); 4.2075 (0.5); 4.1572 (16.0); 4.1179 (13.8); 4.0888 (0.5); 4.0408 (0.4); 3.9751 (0.5); 3.9466 (0.7); 3.9267 (0.5); 3.8852 (0.4); 3.8613 (0.5); 3.8302 (0.5); 3.8102 (0.5); 3.7760 (14.1); 3.7667 (3.1); 3.7567 (5.0); 3.7460 (7.3); 3.7355 (7.6); 3.7251 (6.9); 3.7151 (5.3); 3.7043 (2.7); 3.6830 (0.7); 3.6480 (0.7); 3.6187 (0.8); 3.5891 (0.9); 3.5436 (1.1); 3.5103 (2.8); 3.4910 (2.7); 3.4693 (2.4); 3.3132 (248.5); 3.1696 (3.7); 3.1241 (0.9); 3.0929 (11.2); 3.0592 (0.7); 3.0500 (0.6); 3.0368 (0.6); 3.0291 (0.6); 3.0023 (0.6); 2.9993 (0.6); 2.9374 (0.5); 2.9081 (0.6); 2.8777 (0.6); 2.8287 (0.5); 2.8087 (0.4); 2.6914 (10.5); 2.6812 (11.0); 2.6742 (4.4); 2.6694 (5.8); 2.6650 (4.5); 2.6516 (13.1); 2.6415 (12.4); 2.6234 (0.7); 2.6006 (1.2); 2.5679 (0.6); 2.5546 (3.7); 2.5498 (5.6); 2.5456 (4.7); 2.5227 (10.4); 2.5092 (317.6); 2.5048 (667.4); 2.5004 (914.8); 2.4960 (655.6); 2.4917 (310.5); 2.4571 (3.3); 2.4470 (1.0); 2.4399 (1.9); 2.4225 (3.5); 2.4149 (3.2); 2.3983 (8.4); 2.3810 (6.5); 2.3751 (6.0); 2.3578 (5.9); 2.3454 (12.8); 2.3231 (16.2); 2.3052 (14.9); 2.2904 (6.5); 2.2829 (12.6); 2.2659 (8.8); 2.2494 (1.8); 2.2386 (5.1); 2.2259 (5.8); 2.2166 (4.1); 2.1984 (5.0); 2.1862 (4.5); 2.1801 (3.7); 2.1681 (5.7); 2.1625 (3.6); 2.1568 (2.4); 2.1487 (3.5); 2.1423 (3.8); 2.1249 (2.0); 2.0714 (3.1); 1.7589 (0.5); 1.7421 (2.6); 1.7307 (5.0); 1.7186 (5.9); 1.7075 (5.0); 1.6999 (5.6); 1.6944 (3.7); 1.6874 (5.3); 1.6754 (3.7); 1.6630 (2.4); 1.5083 (0.5); 1.3602 (0.6); 1.3432 (0.5); 1.2361 (6.2); 1.1965 (0.8); 1.1755 (0.7); 1.1588 (0.7); 1.1415 (0.7); 1.0849 (0.5); 0.9120 (0.7); 0.8950 (0.5); 0.8681 (0.7); 0.8532 (1.1); 0.8360 (0.9); 0.8148 (0.6); 0.1469 (1.0); 0.0498 (1.2); 0.0081 (6.4); 0.0006 (191.7); 0.0000 (199.1) I.1-046: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.7567 (0.8); 8.3619 (3.9); 8.3516 (3.1); 8.3412 (3.9); 8.3310 (2.9); 7.3727 (1.3); 7.3473 (3.1); 7.3267 (3.3); 7.3062 (1.8); 7.2825 (3.5); 7.2643 (9.7); 7.2466 (14.1); 7.2294 (8.3); 7.2177 (14.3); 7.2114 (12.4); 7.2047 (9.5); 7.2001 (9.4); 7.1862 (8.9); 7.1690 (4.5); 7.0540 (2.1); 7.0381 (4.4); 7.0187 (3.5); 7.0020 (1.2); 4.6968 (3.4); 4.6775 (2.5); 4.6566 (3.8); 4.6384 (2.9); 4.4900 (1.5); 4.4786 (1.5); 4.4653 (2.2); 4.4546 (2.5); 4.4442 (2.5); 4.4331 (2.2); 4.4229 (1.5); 4.3971 (1.0); 4.1805 (4.0); 4.1404 (3.6); 4.1247 (2.8); 4.0835 (2.5); 3.9638 (2.9); 3.6687 (2.2); 3.6574 (2.8); 3.6472 (2.9); 3.6368 (2.6); 3.6242 (2.3); 3.6140 (1.9); 3.6026 (1.6); 3.4414 (69.2); 3.1663 (16.0); 3.0935 (2.3); 3.0824 (2.9); 3.0744 (1.9); 3.0592 (3.0); 3.0482 (3.4); 3.0402 (2.2); 2.8384 (3.1); 2.8128 (3.2); 2.8038 (2.9); 2.7783 (2.5); 2.6990 (1.6); 2.6790 (2.2); 2.6745 (4.8); 2.6699 (6.7); 2.6653 (4.8); 2.5568 (1.6); 2.5522 (1.6); 2.5471 (1.3); 2.5401 (3.9); 2.5363 (4.6); 2.5233 (18.8); 2.5186 (27.7); 2.5100 (388.7); 2.5054 (843.8); 2.5008 (1175.8); 2.4962 (827.4); 2.4916 (375.5); 2.4669 (3.8); 2.4568 (5.0); 2.4521 (3.3); 2.4468 (1.7); 2.3812 (1.3); 2.3369 (2.9); 2.3322 (5.5); 2.3276 (7.5); 2.3229 (5.4); 2.3181 (2.8); 2.2913 (2.0); 2.2695 (3.3); 2.2476 (4.0); 2.2270 (3.8); 2.1974 (2.3); 2.1880 (4.2); 2.1728 (5.5); 2.1654 (5.0); 2.1529 (4.8); 2.1377 (3.5); 2.1316 (3.5); 2.1158 (3.3); 2.0732 (1.8); 1.9407 (1.1); 1.9087 (1.3); 1.8851 (1.6); 1.8636 (1.8); 1.8513 (1.3); 1.8393 (1.6); 1.8316 (1.9); 1.8073 (1.7); 1.7879 (0.8); 1.6787 (1.0); 1.6661 (1.3); 1.6558 (1.3); 1.6449 (1.3); 1.4707 (1.2); 1.4600 (1.8); 1.4491 (1.6); 1.4377 (1.6); 1.4273 (1.6); 1.0281 (2.0); 0.1460 (1.2); 0.0080 (9.4); -0.0002 (340.8); -0.0086 (10.2); -0.1495 (1.0) I.1-047: 1H-NMR (400.1 MHz, CDCl3): δ= 7.3933 (0.3); 7.3855 (3.3); 7.3800 (1.1); 7.3688 (1.1); 7.3633 (3.7); 7.3555 (0.4); 7.2679 (0.3); 7.2670 (0.4); 7.2662 (0.6); 7.2653 (0.7); 7.2609 (28.8); 7.2514 (0.3); 7.0961 (0.6); 7.0857 (0.4); 7.0783 (0.6); 7.0712 (0.6); 7.0672 (0.5); 7.0599 (0.5); 7.0523 (2.3); 7.0459 (1.2); 7.0418 (2.1); 7.0339 (1.0); 7.0282 (0.8); 6.8670 (0.4); 6.8593 (3.4); 6.8538 (1.1); 6.8426 (1.0); 6.8372 (3.2); 6.8294 (0.4); 4.8816 (0.7); 4.8778 (0.8); 4.8429 (0.8); 4.8390 (0.8); 4.2401 (1.1); 4.1991 (2.5); 4.1820 (4.0); 4.1651 (2.0); 3.8721 (0.4); 3.8614 (1.0); 3.8513 (0.6); 3.8408 (0.5); 3.8303 (0.4); 3.7955 (16.0); 3.6680 (1.6); 3.0034 (2.0); 2.9865 (4.2); 2.9695 (1.9); 2.7015 (0.9); 2.6915 (0.9); 2.6627 (1.1); 2.6527 (1.0); 2.5003 (0.6); 2.4818 (0.5); 2.4773 (0.4); 2.4583 (0.5); 2.4281 (0.5); 2.4140 (0.7); 2.4036 (0.8); 2.3964 (1.3); 2.3893 (0.8); 2.3853 (0.4); 2.3744 (1.2); 2.3605 (0.5); 2.3576 (1.0); 2.3467 (0.4); 2.3356 (0.9); 2.3009 (0.3); 2.2817 (0.4); 2.2685 (0.4); 2.2633 (0.3); 2.2572 (0.3); 2.2491 (0.4); 2.2440 (0.3); 2.2245 (0.3); 2.0923 (1.1); 1.8509 (0.4); 1.8486 (0.4); 1.8377 (0.5); 1.8295 (0.4); 1.8272 (0.4); 1.8244 (0.3); 1.8184 (0.4); 1.8160 (0.4); 1.8047 (0.4); 1.5634 (1.2) I.1-048: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5187 (0.4); 7.3014 (4.4); 7.2812 (5.5); 7.2755 (1.2); 7.2616 (58.1); 7.2599 (62.6); 7.2091 (0.8); 7.1221 (4.6); 7.1012 (3.6); 7.0874 (0.7); 7.0797 (1.1); 7.0721 (1.1); 7.0618 (0.7); 7.0518 (3.7); 7.0417 (3.7); 7.0332 (1.3); 7.0290 (1.3); 6.9961 (0.4); 4.8778 (1.6); 4.8392 (1.7); 4.2391 (2.4); 4.2249 (3.1); 4.2078 (6.4); 4.2007 (2.3); 4.1912 (3.2); 3.8783 (0.3); 3.8682 (0.7); 3.8574 (1.0); 3.8470 (1.2); 3.8366 (1.0); 3.8264 (0.7); 3.8157 (0.3); 3.0740 (3.2); 3.0570 (6.3); 3.0402 (3.0); 2.6982 (1.4); 2.6883 (1.4); 2.6594 (1.8); 2.6494 (1.7); 2.5387 (0.4); 2.5206 (0.5); 2.5144 (0.5); 2.4960 (1.2); 2.4776 (1.1); 2.4718 (0.9); 2.4537 (1.0); 2.4246 (1.2); 2.4106 (1.0); 2.4005 (1.2); 2.3869 (3.0); 2.3661 (2.0); 2.3580 (0.8); 2.3483 (1.6); 2.3439 (0.8); 2.3216 (16.0); 2.2966 (0.5); 2.2778 (0.7); 2.2710 (0.4); 2.2637 (0.6); 2.2589 (0.5); 2.2534 (0.6); 2.2451 (0.9); 2.2393 (0.5); 2.2346 (0.4); 2.2253 (0.5); 2.2207 (0.6); 2.2015 (0.3); 2.0046 (0.5); 1.8555 (0.4); 1.8434 (0.7); 1.8311 (0.8); 1.8218 (0.7); 1.8103 (0.7); 1.8081 (0.7); 1.7985 (0.7); 1.7868 (0.5); 1.5476 (23.8); 0.0018 (5.3) I.1-049: 1H-NMR (400.0 MHz, CDCl3): δ= 7.3483 (0.5); 7.3441 (0.6); 7.3275 (0.9); 7.3107 (0.6); 7.3065 (0.6); 7.2649 (8.0); 7.1927 (1.0); 7.1766 (0.6); 7.1726 (0.5); 7.0784 (0.9); 7.0759 (0.9); 7.0586 (1.3); 7.0562 (1.4); 7.0391 (0.6); 7.0365 (0.6); 5.3007 (1.1); 4.8692 (0.9); 4.8324 (1.0); 4.2589 (1.3); 4.2200 (1.2); 3.9037 (0.6); 3.8933 (0.8); 3.8830 (0.6); 3.6676 (16.0); 2.7314 (0.9); 2.7210 (1.0); 2.6924 (1.2); 2.6821 (1.2); 2.5138 (0.7); 2.4948 (0.6); 2.4901 (0.5); 2.4717 (0.6); 2.4429 (1.9); 2.4281 (0.8); 2.4214 (1.4); 2.4182 (1.1); 2.4040 (1.9); 2.3825 (1.0); 2.3751 (0.5); 2.3613 (0.5); 2.3035 (0.5); 2.2714 (0.6); 1.8554 (0.5); 1.2611 (0.5); 1.2544 (1.0); - 0.0002 (4.9) I.1-050: 1H-NMR (400.1 MHz, d6-DMSO): δ= 8.1400 (0.8); 8.1190 (0.8); 8.0535 (1.4); 8.0319 (1.4); 7.3771 (0.6); 7.3733 (0.6); 7.3525 (1.3); 7.3310 (1.4); 7.3106 (0.6); 7.2016 (0.7); 7.1828 (1.3); 7.1700 (1.4); 7.1502 (0.7); 7.0904 (1.0); 7.0715 (1.6); 7.0562 (0.8); 4.7376 (1.8); 4.6973 (2.0); 4.3465 (1.3); 4.3350 (1.4); 4.3245 (1.3); 4.3131 (1.4); 4.2479 (2.1); 4.2079 (1.8); 4.1679 (0.8); 4.1530 (0.8); 4.1472 (0.8); 4.1323 (0.8); 3.8020 (0.4); 3.7918 (0.8); 3.7808 (1.2); 3.7701 (1.5); 3.7599 (1.2); 3.7496 (0.9); 3.7390 (0.5); 3.4708 (0.3); 3.3853 (16.0); 2.6741 (0.6); 2.6692 (0.8); 2.6647 (0.6); 2.6570 (1.1); 2.6460 (1.0); 2.6312 (0.6); 2.6224 (1.5); 2.6114 (1.2); 2.5966 (0.8); 2.5856 (0.8); 2.5397 (0.5); 2.5227 (1.2); 2.5094 (40.5); 2.5048 (89.4); 2.5002 (126.9); 2.4956 (92.5); 2.4910 (44.2); 2.4498 (0.4); 2.4187 (0.4); 2.3957 (0.8); 2.3768 (1.2); 2.3545 (1.4); 2.3357 (2.2); 2.3274 (1.2); 2.3227 (0.9); 2.3138 (1.7); 2.3016 (1.2); 2.2936 (0.9); 2.2880 (1.1); 2.2792 (1.6); 2.2762 (1.4); 2.2636 (1.4); 2.2511 (1.3); 2.2332 (0.6); 2.2213 (0.7); 2.2094 (0.7); 2.1245 (0.5); 2.1047 (1.0); 2.0928 (0.8); 2.0808 (1.0); 2.0716 (1.7); 2.0616 (0.5); 2.0490 (1.0); 2.0296 (0.4); 1.8788 (0.4); 1.8617 (0.7); 1.8494 (0.8); 1.8438 (1.1); 1.8318 (1.3); 1.8205 (0.9); 1.8113 (1.0); 1.8023 (0.9); 1.7986 (0.9); 1.7889 (0.9); 1.7774 (0.8); 1.7721 (0.6); 1.7661 (0.6); 1.7481 (0.5); 1.3824 (0.4); 1.3717 (0.3); 1.3636 (0.3); 1.2960 (0.4); 1.2781 (0.7); 1.2615 (1.0); 1.2441 (1.0); 1.2260 (0.8); 1.2077 (0.5); 1.1896 (0.4); 1.1729 (0.5); 1.1669 (0.4); 1.1535 (0.8); 1.1347 (1.2); 1.1170 (0.9); 1.1004 (0.7); 1.0826 (0.4); 0.8484 (13.8); 0.8314 (15.4); 0.8156 (4.2); 0.0082 (0.4) I.1-051: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1339 (4.0); 7.1115 (12.4); 7.0979 (8.4); 7.0901 (4.2); 7.0778 (1.9); 6.9528 (3.6); 6.9418 (3.6); 6.9356 (1.7); 6.9298 (2.7); 6.9188 (2.6); 4.6503 (2.0); 4.6119 (2.2); 4.3157 (1.3); 4.3053 (3.3); 4.2946 (3.4); 4.2844 (1.5); 4.1260 (3.2); 4.1147 (4.8); 4.1036 (2.4); 4.0517 (2.2); 4.0133 (1.9); 3.7274 (0.7); 3.7168 (1.1); 3.7059 (1.2); 3.6958 (1.0); 3.6853 (0.7); 3.3469 (2.4); 3.3223 (495.0); 3.2912 (0.8); 3.1675 (0.9); 2.7817 (1.4); 2.7713 (1.4); 2.7416 (1.8); 2.7315 (1.6); 2.6704 (1.0); 2.5403 (0.7); 2.5102 (64.0); 2.5058 (132.9); 2.5013 (180.1); 2.4968 (126.4); 2.4925 (58.1); 2.4797 (2.7); 2.4579 (2.0); 2.4400 (1.6); 2.4180 (1.8); 2.3913 (1.3); 2.3728 (1.0); 2.3496 (0.8); 2.3280 (1.1); 2.2634 (16.0); 2.2501 (1.4); 2.2363 (1.3); 2.2080 (0.7); 2.1952 (0.8); 2.1376 (0.7); 2.1251 (0.6); 2.1125 (0.6); 2.1062 (0.9); 2.0874 (0.6); 2.0730 (0.8); 1.7173 (0.6); 1.7051 (0.8); 1.6944 (0.7); 1.6846 (0.7); 1.6733 (0.7); 1.6603 (0.6); -0.0002 (5.3) I.1-052: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2642 (2.9); 7.2466 (4.4); 7.2114 (4.8); 3.3179 (1950.0); 3.2683 (4.4); 3.1666 (16.0); 2.6747 (5.7); 2.6699 (8.5); 2.6652 (5.5); 2.5402 (3.9); 2.5234 (18.8); 2.5186 (28.8); 2.5100 (477.4); 2.5054 (1050.3); 2.5008 (1468.1); 2.4962 (1027.3); 2.4916 (461.4); 2.4560 (4.0); 2.3323 (6.1); 2.3276 (8.3); 2.3228 (6.3); 2.1528 (2.0); 2.0729 (2.6); -0.0002 (69.2) I.1-053: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8999 (0.8); 7.8930 (6.8); 7.8879 (1.9); 7.8758 (2.0); 7.8706 (7.1); 7.8636 (0.6); 7.1256 (1.8); 7.1052 (7.8); 7.0929 (8.4); 7.0720 (1.8); 7.0253 (0.8); 7.0183 (6.7); 7.0131 (1.8); 7.0011 (1.8); 6.9959 (6.3); 6.9888 (0.5); 4.6458 (1.9); 4.6073 (2.2); 4.3537 (1.1); 4.3430 (2.7); 4.3337 (2.9); 4.3241 (1.6); 4.2367 (3.0); 4.2256 (3.7); 4.2150 (1.8); 4.0487 (2.2); 4.0106 (2.0); 3.7270 (0.7); 3.7165 (1.0); 3.7061 (1.2); 3.6959 (1.0); 3.6856 (0.8); 3.3211 (219.8); 3.2724 (0.8); 3.1693 (2.0); 2.7811 (1.4); 2.7710 (1.5); 2.7413 (1.8); 2.7311 (1.7); 2.6746 (0.7); 2.6699 (0.9); 2.6653 (0.7); 2.5400 (0.5); 2.5233 (2.6); 2.5186 (3.7); 2.5100 (54.7); 2.5054 (118.2); 2.5008 (164.3); 2.4962 (113.4); 2.4916 (50.6); 2.4808 (2.5); 2.4591 (2.1); 2.4411 (1.7); 2.4267 (0.6); 2.4193 (1.7); 2.4087 (0.6); 2.4025 (0.6); 2.3854 (1.1); 2.3670 (0.9); 2.3612 (0.8); 2.3437 (0.8); 2.3322 (0.7); 2.3275 (1.0); 2.3230 (0.7); 2.2596 (16.0); 2.2448 (1.4); 2.2310 (1.3); 2.2143 (0.5); 2.2028 (0.8); 2.1899 (0.8); 2.1344 (0.7); 2.1221 (0.6); 2.1163 (0.5); 2.1094 (0.6); 2.1027 (0.8); 2.0840 (0.5); 2.0780 (0.6); 2.0707 (0.7); 1.7152 (0.6); 1.7036 (0.8); 1.6928 (0.7); 1.6832 (0.7); 1.6718 (0.8); -0.0002 (0.8) I.1-055: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5192 (0.4); 7.3112 (0.8); 7.2604 (80.4); 7.2118 (0.7); 7.1461 (0.5); 7.1254 (1.1); 7.1215 (0.9); 7.1152 (0.6); 7.1094 (0.6); 7.1050 (0.9); 7.1004 (1.4); 7.0894 (0.8); 7.0803 (1.1); 7.0684 (0.6); 7.0636 (0.6); 6.9966 (1.1); 6.9877 (0.6); 6.9766 (0.6); 6.9738 (0.6); 4.7296 (0.4); 4.6329 (1.3); 4.5946 (1.6); 4.2674 (1.6); 4.2290 (1.3); 4.1073 (0.4); 4.0753 (0.6); 4.0667 (0.8); 4.0555 (1.1); 4.0451 (0.7); 4.0359 (0.6); 3.6587 (3.7); 3.1766 (15.7); 3.1143 (16.0); 2.9657 (1.0); 2.9540 (1.1); 2.9497 (3.7); 2.9235 (1.3); 2.9122 (1.2); 2.8491 (1.8); 2.8357 (1.7); 2.6744 (1.3); 2.6544 (1.2); 2.6324 (1.0); 2.6124 (1.0); 2.5892 (0.6); 2.5776 (0.4); 2.5707 (0.4); 2.5473 (0.9); 2.5276 (1.0); 2.5048 (0.8); 2.4772 (0.6); 2.4635 (0.7); 2.4530 (0.9); 2.4396 (0.9); 2.4344 (0.5); 2.4202 (0.4); 2.4101 (0.5); 2.3973 (0.5); 2.3901 (0.5); 2.3721 (0.5); 2.3536 (0.7); 2.3408 (0.4); 2.3344 (0.4); 2.3300 (0.7); 2.3214 (0.7); 2.3167 (0.4); 2.3011 (0.4); 2.2967 (0.6); 2.0045 (0.4); 1.8379 (0.4); 1.8257 (0.6); 1.8145 (0.7); 1.8047 (0.6); 1.7925 (0.6); 1.7816 (0.6); 1.7700 (0.4); 1.6010 (0.6); 1.5499 (63.7); 1.5012 (0.6); 0.0000 (11.2) I.1-056: 1H-NMR (400.1 MHz, d6-DMSO): δ= 10.8047 (0.8); 7.3597 (0.5); 7.3554 (0.6); 7.3494 (0.4); 7.3393 (0.4); 7.3335 (0.6); 7.3292 (0.6); 7.3132 (0.3); 7.3092 (0.3); 7.1925 (0.6); 7.1891 (0.6); 7.1797 (0.6); 7.1764 (0.6); 7.1722 (0.5); 7.1684 (0.4); 7.1594 (0.4); 7.1559 (0.4); 7.0987 (0.6); 7.0825 (0.8); 7.0637 (0.4); 4.7545 (0.9); 4.7142 (1.0); 4.3051 (1.1); 4.2654 (1.0); 3.9296 (0.4); 3.9189 (0.5); 3.9091 (0.6); 3.8992 (0.5); 3.8886 (0.4); 3.3273 (29.0); 3.1686 (0.6); 2.9026 (0.6); 2.8921 (0.6); 2.8652 (0.7); 2.8547 (0.7); 2.6067 (0.7); 2.5852 (0.7); 2.5689 (0.6); 2.5472 (0.8); 2.5401 (0.4); 2.5233 (0.8); 2.5185 (1.2); 2.5100 (17.2); 2.5055 (37.2); 2.5008 (51.8); 2.4963 (37.8); 2.4918 (18.8); 2.4465 (0.5); 2.4223 (0.7); 2.4041 (0.6); 2.3994 (0.6); 2.3825 (0.4); 2.3321 (0.6); 2.3280 (0.4); 2.3190 (0.6); 2.3079 (0.8); 2.2951 (0.8); 2.2687 (16.0); 2.2564 (1.1); 2.2398 (0.6); 2.2279 (0.5); 2.2214 (0.4); 2.2093 (0.6); 2.1898 (0.4); 2.1847 (0.4); 1.8520 (0.4); 1.8404 (0.5); 1.8300 (0.4); 1.8225 (0.5); 1.8096 (0.4); 1.1588 (0.4) I.1-057: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3344 (5.4); 7.3292 (1.8); 7.3174 (1.8); 7.3120 (6.2); 7.3031 (0.6); 7.1299 (1.9); 7.1094 (7.6); 7.0967 (8.1); 7.0761 (1.9); 6.9719 (0.6); 6.9632 (6.0); 6.9580 (1.9); 6.9462 (1.7); 6.9408 (5.4); 4.6497 (2.0); 4.6116 (2.3); 4.3234 (1.2); 4.3131 (3.2); 4.3032 (3.2); 4.2938 (1.6); 4.1501 (3.1); 4.1388 (4.5); 4.1278 (2.4); 4.0492 (2.3); 4.0111 (2.1); 3.7237 (0.7); 3.7131 (1.1); 3.7028 (1.2); 3.6927 (1.1); 3.6822 (0.8); 3.4331 (6.7); 2.7809 (1.3); 2.7708 (1.3); 2.7411 (1.7); 2.7310 (1.6); 2.5061 (18.9); 2.5018 (25.9); 2.4975 (19.1); 2.4782 (1.8); 2.4564 (1.7); 2.4384 (1.4); 2.4310 (0.5); 2.4166 (1.6); 2.4065 (0.6); 2.3887 (1.2); 2.3706 (0.9); 2.3651 (0.9); 2.3471 (0.8); 2.2631 (16.0); 2.2485 (1.3); 2.2345 (1.2); 2.2066 (0.7); 2.1932 (0.7); 2.1336 (0.7); 2.1208 (0.6); 2.1151 (0.5); 2.1087 (0.6); 2.1022 (0.9); 2.0831 (0.5); 2.0774 (0.6); 1.7120 (0.7); 1.7004 (0.8); 1.6892 (0.7); 1.6801 (0.7); 1.6686 (0.7); 1.6564 (0.5) I.1-058: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.5589 (2.7); 7.5544 (3.4); 7.5384 (4.3); 7.5334 (4.0); 7.3988 (4.8); 7.3785 (4.1); 7.3562 (1.0); 7.3360 (1.1); 7.3116 (0.8); 7.2081 (0.6); 7.1879 (1.1); 7.1764 (1.1); 7.1545 (0.6); 7.0864 (0.7); 7.0631 (1.2); 7.0577 (0.8); 4.7215 (0.8); 4.7116 (1.0); 4.6810 (1.0); 4.6709 (1.0); 4.3054 (0.3); 4.2746 (1.5); 4.2625 (2.1); 4.2557 (2.8); 4.2503 (1.9); 4.2446 (1.7); 4.2315 (1.8); 4.2204 (0.6); 4.1930 (1.3); 4.0877 (0.6); 4.0744 (0.6); 3.7487 (0.9); 3.7366 (0.9); 3.7194 (0.6); 3.4608 (0.9); 3.4103 (1.4); 3.3630 (9.7); 3.3123 (1240.8); 3.2884 (22.2); 3.2619 (8.4); 3.2432 (0.9); 3.2298 (1.2); 3.2139 (2.2); 3.2093 (0.6); 3.1956 (1.2); 3.1910 (0.9); 3.1753 (2.9); 3.1622 (2.3); 3.0761 (0.7); 3.0673 (1.2); 3.0544 (0.7); 3.0481 (0.8); 3.0412 (0.6); 3.0327 (0.8); 3.0134 (0.5); 2.9124 (0.4); 2.6973 (0.8); 2.6875 (1.4); 2.6787 (1.6); 2.6741 (2.1); 2.6697 (2.8); 2.6647 (2.1); 2.6574 (1.4); 2.6477 (2.0); 2.6375 (1.0); 2.5989 (0.7); 2.5948 (0.8); 2.5600 (2.4); 2.5558 (3.2); 2.5513 (3.4); 2.5466 (1.5); 2.5228 (4.0); 2.5182 (6.8); 2.5096 (153.0); 2.5051 (339.6); 2.5005 (481.2); 2.4959 (349.1); 2.4913 (165.5); 2.4592 (1.8); 2.4545 (2.7); 2.4501 (4.0); 2.4458 (3.5); 2.4410 (2.4); 2.4320 (2.1); 2.4201 (1.6); 2.4119 (2.1); 2.3986 (1.3); 2.3920 (1.4); 2.3793 (1.2); 2.3643 (16.0); 2.3492 (1.3); 2.3364 (1.1); 2.3320 (2.1); 2.3273 (2.9); 2.3229 (2.1); 2.2906 (0.8); 2.2778 (0.9); 2.2662 (1.3); 2.2536 (1.4); 2.2246 (0.9); 2.2136 (1.2); 2.1977 (0.7); 2.1852 (0.7); 2.1599 (0.8); 2.1408 (0.7); 2.1175 (0.4); 2.0722 (2.2); 1.7320 (0.6); 1.7230 (0.6); 1.7119 (0.8); 1.7010 (0.8); 1.6928 (0.8); 1.6804 (0.6); 1.6692 (0.6); 0.1456 (0.4); 0.0505 (0.8); 0.0080 (2.6); 0.0000 (84.3) I.1-060: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5205 (0.8); 7.5184 (1.0); 7.3836 (4.8); 7.3802 (6.7); 7.3780 (7.9); 7.3728 (3.4); 7.3647 (6.2); 7.3626 (9.5); 7.3602 (12.8); 7.3158 (3.9); 7.3137 (6.6); 7.3115 (5.7); 7.3064 (3.9); 7.3038 (3.6); 7.2954 (11.8); 7.2935 (11.2); 7.2898 (7.2); 7.2847 (5.3); 7.2726 (17.3); 7.2687 (14.4); 7.2679 (14.2); 7.2617 (127.9); 7.2596 (163.4); 7.2520 (4.3); 7.2374 (4.0); 7.2350 (4.6); 7.2317 (2.6); 7.2225 (2.2); 7.2181 (5.5); 7.2014 (1.6); 7.1987 (1.6); 7.1957 (0.7); 6.9979 (5.7); 6.9803 (6.2); 6.9662 (3.2); 6.9599 (3.8); 6.9357 (3.6); 6.9308 (3.4); 6.9066 (3.3); 4.8227 (5.4); 4.7839 (6.0); 4.2467 (0.8); 4.2355 (7.4); 4.2185 (15.0); 4.2017 (7.6); 4.1191 (5.9); 4.0805 (5.4); 3.8792 (1.0); 3.8677 (2.0); 3.8583 (2.8); 3.8475 (3.6); 3.8370 (2.7); 3.8267 (1.9); 3.8156 (0.9); 3.1215 (1.1); 3.1097 (8.5); 3.0929 (16.0); 3.0761 (7.5); 2.5906 (3.5); 2.5797 (3.2); 2.5516 (4.9); 2.5411 (5.3); 2.5171 (3.0); 2.4986 (2.8); 2.4934 (2.6); 2.4747 (2.6); 2.4569 (2.3); 2.4421 (2.7); 2.4326 (3.1); 2.4179 (3.1); 2.3993 (1.0); 2.3896 (1.4); 2.3751 (1.3); 2.3281 (4.4); 2.3068 (4.4); 2.2966 (1.6); 2.2891 (3.6); 2.2781 (2.4); 2.2677 (4.0); 2.2581 (1.6); 2.2539 (1.8); 2.2455 (2.3); 2.2343 (1.1); 2.2256 (1.4); 2.2214 (1.7); 2.2014 (0.8); 1.8383 (1.2); 1.8264 (1.8); 1.8142 (2.1); 1.8051 (2.1); 1.8026 (2.0); 1.7933 (1.9); 1.7908 (2.0); 1.7814 (1.7); 1.7696 (1.3); 1.7558 (0.8); 1.5457 (59.1); 0.1465 (0.3); 0.0128 (4.6); 0.0081 (5.4); 0.0022 (47.7) I.1-063: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6522 (1.8); 7.3660 (0.5); 7.3440 (0.5); 7.1951 (0.6); 7.1916 (0.6); 7.1822 (0.5); 7.1791 (0.6); 7.0874 (0.6); 7.0714 (0.8); 4.7420 (0.8); 4.7023 (1.0); 4.2438 (1.1); 4.2040 (0.9); 3.7934 (0.6); 3.7833 (0.7); 3.7732 (0.6); 3.5596 (16.0); 2.5201 (0.8); 2.5114 (10.1); 2.5068 (20.3); 2.5023 (28.0); 2.4977 (19.8); 2.4932 (8.8); 2.4767 (1.0); 2.4654 (0.7); 2.3728 (0.6); 2.3527 (0.6); 2.3297 (0.6); 2.2782 (0.5); 2.2670 (0.6); 2.2542 (0.6); 2.1999 (0.9); 2.1782 (0.8); 2.1650 (0.8); 2.1431 (0.9); 1.3492 (1.4); 1.3385 (1.4); 1.3292 (1.3); 1.1744 (0.7); 0.9786 (0.7); 0.9733 (1.3); 0.9694 (1.8); 0.9612 (1.6); 0.9516 (0.5); -0.0002 (5.4) I.1-066: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3541 (0.8); 7.3510 (1.4); 7.3471 (0.6); 7.3382 (0.9); 7.3338 (3.7); 7.3302 (2.0); 7.3185 (1.3); 7.3151 (3.2); 7.3133 (2.2); 7.3100 (0.6); 7.2830 (0.6); 7.2794 (1.4); 7.2759 (1.0); 7.2612 (1.7); 7.2430 (0.6); 7.2260 (2.6); 7.2223 (3.2); 7.2170 (0.7); 7.2054 (2.3); 4.6882 (1.6); 4.6495 (1.8); 4.1239 (1.8); 4.0852 (1.6); 4.0367 (1.4); 4.0194 (4.2); 4.0189 (4.3); 4.0015 (4.6); 3.9837 (1.7); 3.9423 (1.5); 3.7579 (0.6); 3.7473 (0.9); 3.7372 (1.0); 3.7271 (0.9); 3.7166 (0.6); 3.4648 (0.5); 3.4473 (1.6); 3.4298 (1.6); 3.4123 (0.5); 2.7387 (1.3); 2.7283 (1.3); 2.6990 (1.7); 2.6887 (1.6); 2.5192 (0.6); 2.5105 (8.6); 2.5059 (18.5); 2.5013 (25.8); 2.4967 (18.0); 2.4921 (8.0); 2.4473 (2.1); 2.4307 (0.5); 2.4256 (2.2); 2.4076 (2.3); 2.3859 (1.9); 2.3662 (0.6); 2.3064 (0.7); 2.2926 (0.8); 2.2819 (1.1); 2.2682 (1.1); 2.2648 (0.5); 2.2401 (0.7); 2.2269 (0.7); 2.1761 (0.6); 2.1641 (0.6); 2.1460 (0.7); 1.7250 (0.5); 1.7140 (0.8); 1.7032 (0.5); 1.6936 (0.6); 1.6821 (0.7); 1.1488 (7.2); 1.1311 (16.0); 1.1133 (7.1); 1.0727 (1.6); 1.0552 (3.3); 1.0377 (1.6); - 0.0002 (2.3) I.1-067: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9605 (3.6); 7.3729 (1.6); 7.3521 (3.5); 7.3305 (3.5); 7.3096 (1.9); 7.2064 (2.1); 7.2023 (2.2); 7.1936 (2.1); 7.1865 (3.8); 7.1826 (3.9); 7.1737 (3.7); 7.1701 (4.0); 7.1661 (2.5); 7.1620 (2.3); 7.1533 (2.1); 7.1495 (2.2); 7.0734 (3.7); 7.0576 (5.1); 7.0381 (2.7); 4.7356 (6.1); 4.6957 (7.1); 4.6274 (1.2); 4.2328 (7.4); 4.1925 (6.3); 3.8088 (1.2); 3.7985 (2.3); 3.7883 (3.5); 3.7780 (4.3); 3.7677 (3.6); 3.7572 (2.5); 3.7464 (1.3); 3.3775 (6.7); 3.3624 (14.5); 3.3474 (8.9); 3.3072 (176.5); 3.2559 (1.6); 3.1685 (0.8); 3.1067 (6.0); 3.0920 (16.0); 3.0774 (14.8); 3.0624 (4.8); 2.6739 (2.1); 2.6692 (3.0); 2.6646 (2.1); 2.5395 (2.4); 2.5229 (11.1); 2.5180 (10.8); 2.5094 (174.1); 2.5048 (381.4); 2.5001 (535.0); 2.4955 (370.0); 2.4909 (167.8); 2.4771 (8.4); 2.4502 (2.1); 2.4038 (1.4); 2.3992 (0.5); 2.3855 (2.4); 2.3620 (4.6); 2.3424 (4.2); 2.3316 (2.6); 2.3269 (3.6); 2.3193 (4.0); 2.2776 (3.3); 2.2645 (4.2); 2.2535 (5.2); 2.2406 (4.9); 2.2358 (2.3); 2.2229 (2.1); 2.2124 (8.5); 2.1989 (3.3); 2.1911 (6.4); 2.1779 (5.5); 2.1564 (5.3); 2.1397 (1.9); 2.1202 (3.2); 2.1158 (2.0); 2.1082 (2.3); 2.1010 (2.0); 2.0963 (2.8); 2.0887 (3.9); 2.0770 (1.5); 2.0689 (2.3); 2.0646 (3.0); 2.0451 (1.3); 1.7806 (1.6); 1.7684 (2.2); 1.7572 (3.2); 1.7474 (2.7); 1.7351 (2.7); 1.7253 (2.8); 1.7145 (1.8); 1.7019 (1.2); 0.0080 (1.6); -0.0002 (56.0); -0.0086 (1.8) I.1-069: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1539 (8.0); 7.1387 (6.8); 3.3493 (12.3); 3.3156 (1369.1); 2.6743 (9.8); 2.6696 (14.6); 2.6651 (9.8); 2.5680 (6.2); 2.5390 (19.6); 2.5342 (27.3); 2.5295 (24.1); 2.5233 (41.0); 2.5184 (58.1); 2.5098 (820.2); 2.5053 (1776.1); 2.5007 (2460.2); 2.4961 (1716.3); 2.4915 (763.2); 2.4506 (5.4); 2.3322 (10.2); 2.3275 (14.2); 2.3229 (10.0); 2.0733 (4.4); 1.1833 (8.0); 1.1644 (16.0); 1.1457 (6.6); 0.8936 (8.6); 0.8775 (7.7); 0.8290 (8.3); 0.8125 (7.9); 0.0081 (9.8); -0.0002 (271.7); -0.0086 (6.8) I.1-070: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9991 (2.5); 8.6323 (0.9); 8.6127 (0.9); 7.4148 (2.3); 7.3595 (0.7); 7.3369 (0.7); 7.1847 (0.7); 7.1725 (0.8); 7.0691 (0.7); 7.0525 (1.0); 4.7152 (1.0); 4.6759 (1.2); 4.6198 (0.5); 4.6103 (0.6); 4.6002 (0.6); 4.5906 (0.5); 4.1730 (1.2); 4.1329 (1.1); 3.7207 (0.6); 3.7100 (0.7); 3.6996 (0.6); 3.6313 (16.0); 3.3542 (134.1); 3.1857 (2.8); 3.1678 (3.3); 3.1510 (0.8); 3.1263 (1.0); 3.1128 (0.9); 3.0374 (1.0); 3.0141 (1.0); 3.0000 (0.7); 2.9763 (0.6); 2.6749 (0.6); 2.6703 (0.8); 2.6656 (0.6); 2.5407 (1.0); 2.5318 (1.2); 2.5238 (2.1); 2.5191 (3.0); 2.5104 (49.9); 2.5058 (108.6); 2.5012 (151.6); 2.4966 (106.3); 2.4920 (47.2); 2.3326 (0.7); 2.3279 (1.1); 2.3232 (1.3); 2.3027 (0.9); 2.2802 (0.7); 2.2720 (1.0); 2.2594 (0.6); 2.2499 (1.1); 2.2362 (1.3); 2.2226 (0.9); 2.2156 (1.0); 2.0292 (0.6); 1.7013 (0.5); 1.6913 (0.5); 0.0080 (0.5); -0.0002 (16.5) I.1-073: 1H-NMR (400.1 MHz, CDCl3): δ= 17.2398 (0.3); 15.8901 (0.6); 13.9985 (0.3); 7.5185 (3.1); 7.3594 (0.5); 7.3160 (2.6); 7.2977 (5.6); 7.2797 (7.0); 7.2756 (5.4); 7.2598 (550.1); 7.2109 (1.1); 7.1584 (0.4); 7.1530 (0.3); 7.0340 (9.7); 7.0150 (8.7); 6.9950 (4.6); 6.9872 (4.8); 6.9689 (16.0); 6.9464 (13.2); 6.7610 (0.3); 5.5547 (0.4); 5.5395 (0.4); 5.5336 (0.4); 5.5086 (0.7); 5.4873 (1.0); 5.4517 (2.3); 5.4223 (1.6); 5.3933 (1.1); 5.3354 (2.2); 4.8824 (0.4); 4.7450 (11.0); 4.7067 (12.8); 4.2529 (12.2); 4.2145 (10.7); 4.1782 (0.6); 4.1329 (0.3); 4.0453 (2.0); 4.0335 (3.8); 4.0246 (4.4); 4.0132 (7.2); 4.0017 (4.6); 3.9934 (4.1); 3.9814 (2.0); 3.5288 (1.0); 3.4919 (1.4); 2.6255 (0.4); 2.5928 (1.7); 2.5696 (10.0); 2.5575 (8.2); 2.5500 (6.7); 2.5320 (14.2); 2.5201 (10.5); 2.5071 (5.2); 2.4921 (4.9); 2.4776 (5.5); 2.4678 (6.6); 2.4537 (6.9); 2.4350 (1.9); 2.4249 (3.1); 2.4109 (3.4); 2.3933 (0.4); 2.3869 (0.4); 2.3709 (0.4); 2.3588 (2.7); 2.3394 (4.4); 2.3261 (3.2); 2.3205 (2.9); 2.3155 (3.6); 2.3069 (4.9); 2.3020 (3.3); 2.2970 (2.2); 2.2879 (2.9); 2.2830 (4.1); 2.2637 (2.0); 2.2485 (0.4); 2.2262 (9.5); 2.2053 (9.4); 2.1888 (7.9); 2.1678 (7.8); 2.0838 (0.6); 2.0236 (0.9); 2.0138 (1.0); 2.0047 (1.2); 1.8513 (15.7); 1.8395 (14.3); 1.8270 (12.0); 1.8174 (10.1); 1.8042 (8.3); 1.7941 (6.6); 1.7831 (5.3); 1.7694 (3.8); 1.7045 (0.9); 1.6337 (0.5); 1.6220 (0.5); 1.5953 (0.5); 1.5880 (0.4); 1.5504 (0.4); 1.2244 (0.3); 0.9752 (0.3); 0.8624 (0.3); 0.8237 (0.3); 0.1455 (1.0); 0.0999 (0.4); 0.0082 (6.5); 0.0000 (199.3) I.1-074: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3499 (4.6); 7.3263 (3.6); 7.2640 (9.4); 7.2465 (15.0); 7.2290 (11.4); 7.2168 (13.4); 7.2108 (16.0); 7.1858 (10.8); 7.0363 (4.8); 7.0215 (5.0); 4.6966 (3.6); 4.6769 (3.8); 4.6572 (4.0); 4.6371 (4.5); 4.1809 (3.8); 4.1394 (4.0); 4.1246 (4.5); 4.0843 (3.8); 3.6475 (3.2); 3.3671 (5.4); 3.3151 (6348.8); 3.2642 (17.1); 3.2158 (5.8); 3.1660 (9.5); 3.0520 (4.0); 2.8323 (3.3); 2.8073 (3.9); 2.6744 (25.2); 2.6697 (35.0); 2.6652 (25.8); 2.6607 (11.2); 2.5400 (23.0); 2.5232 (95.7); 2.5185 (141.3); 2.5098 (1948.2); 2.5053 (4233.3); 2.5007 (5926.9); 2.4960 (4148.6); 2.4915 (1849.1); 2.4552 (12.4); 2.4502 (15.1); 2.4457 (12.4); 2.4059 (5.9); 2.3368 (11.6); 2.3321 (24.8); 2.3275 (34.9); 2.3228 (25.0); 2.3185 (12.0); 2.2696 (4.0); 2.2469 (4.7); 2.2272 (4.7); 2.1878 (5.4); 2.1724 (6.5); 2.1649 (6.7); 2.1537 (6.4); 2.0730 (8.0); 0.0080 (20.9); -0.0002 (707.7); -0.0085 (19.0) I.1-075: 1H-NMR (400.1 MHz, CDCl3): δ= 10.3385 (0.3); 10.3199 (0.4); 7.5193 (1.3); 7.3089 (0.8); 7.2605 (246.9); 7.2126 (0.7); 7.1463 (2.1); 7.1417 (2.4); 7.1220 (7.3); 7.1076 (5.8); 7.1027 (9.1); 7.0973 (6.6); 7.0850 (8.0); 7.0764 (9.5); 7.0680 (9.5); 7.0562 (11.3); 7.0474 (6.5); 7.0363 (6.7); 7.0249 (8.1); 7.0092 (8.8); 6.9966 (4.3); 6.9921 (4.0); 6.7516 (0.5); 5.2983 (4.6); 4.9233 (0.5); 4.8772 (10.9); 4.8384 (12.5); 4.7961 (0.9); 4.3589 (0.4); 4.3341 (1.0); 4.2956 (1.0); 4.2232 (14.4); 4.2064 (1.3); 4.1846 (13.2); 4.1353 (0.9); 4.1194 (0.8); 4.0975 (0.8); 4.0467 (1.3); 4.0344 (1.4); 4.0260 (1.4); 4.0151 (1.4); 3.9968 (3.2); 3.9869 (5.4); 3.9768 (7.7); 3.9668 (9.7); 3.9566 (8.1); 3.9465 (5.9); 3.9367 (3.6); 3.9159 (1.7); 3.9051 (1.7); 3.8947 (1.8); 3.8870 (1.7); 3.8757 (1.7); 3.8439 (1.6); 3.8166 (1.5); 3.8102 (1.5); 3.7902 (1.5); 3.7877 (1.4); 3.7380 (1.3); 3.7195 (1.4); 3.6994 (1.5); 3.6715 (1.5); 3.6530 (1.3); 3.6347 (1.0); 3.6173 (0.8); 3.6084 (0.9); 3.5958 (0.8); 3.5761 (0.8); 3.5599 (0.8); 3.5008 (1.7); 3.4986 (1.7); 3.4934 (2.5); 3.4103 (0.5); 3.3407 (0.9); 3.3205 (0.9); 3.3031 (1.3); 3.2851 (1.9); 3.2672 (2.2); 3.2433 (1.6); 3.1611 (0.3); 3.1358 (1.1); 3.1129 (2.4); 3.1073 (2.3); 3.0368 (0.6); 3.0262 (0.6); 2.9948 (0.6); 2.9840 (0.6); 2.8921 (9.3); 2.8814 (12.8); 2.8768 (13.6); 2.8678 (13.0); 2.8518 (16.0); 2.8415 (12.0); 2.7276 (0.4); 2.7179 (0.8); 2.6992 (0.6); 2.6872 (0.8); 2.6773 (1.1); 2.6563 (11.2); 2.6360 (10.9); 2.6157 (8.6); 2.5955 (10.2); 2.5740 (4.2); 2.5532 (7.4); 2.5315 (8.1); 2.5098 (5.6); 2.4834 (5.0); 2.4711 (6.2); 2.4588 (7.7); 2.4467 (8.0); 2.4406 (3.6); 2.4280 (2.6); 2.4154 (4.0); 2.4036 (4.2); 2.3615 (3.1); 2.3414 (5.3); 2.3288 (3.9); 2.3172 (4.6); 2.3087 (6.2); 2.2971 (2.6); 2.2842 (4.8); 2.2637 (2.0); 2.1833 (0.3); 2.1053 (0.6); 2.0883 (1.7); 2.0689 (2.2); 2.0523 (1.9); 2.0358 (1.0); 2.0077 (1.2); 1.9291 (2.6); 1.9180 (4.4); 1.9066 (4.6); 1.8957 (5.8); 1.8845 (6.1); 1.8739 (4.1); 1.8616 (3.3); 1.8508 (2.2); 1.8346 (0.5); 1.8211 (0.4); 1.8151 (0.4); 1.8012 (0.3); 1.7888 (0.3); 1.3069 (0.6); 1.2888 (1.1); 1.2698 (0.9); 1.2520 (2.9); 1.2339 (4.4); 1.2167 (2.2); 1.1938 (2.2); 1.1757 (4.4); 1.1635 (0.4); 1.1574 (2.0); 1.1493 (0.5); 0.0082 (1.4) I.1-076: 1H-NMR (400.1 MHz, CDCl3): δ= 7.3161 (0.4); 7.2997 (1.0); 7.2835 (1.1); 7.2606 (55.8); 7.0377 (1.2); 7.0187 (1.1); 6.9961 (0.5); 6.9904 (0.7); 6.9835 (0.7); 6.9635 (2.2); 6.9414 (1.8); 4.8362 (0.4); 4.7974 (0.5); 4.6048 (1.3); 4.5660 (1.9); 4.4097 (1.7); 4.3712 (1.2); 4.1380 (0.5); 4.1015 (0.8); 4.0939 (0.6); 4.0823 (1.1); 4.0708 (0.6); 4.0627 (0.6); 3.6477 (4.5); 3.1311 (15.8); 3.0571 (16.0); 2.9488 (2.6); 2.9164 (0.9); 2.9048 (1.0); 2.8739 (1.3); 2.8621 (1.3); 2.8483 (1.3); 2.8349 (1.3); 2.6712 (1.3); 2.6516 (1.3); 2.6411 (0.3); 2.6290 (1.2); 2.6089 (1.0); 2.6024 (0.5); 2.5905 (0.5); 2.5819 (0.3); 2.5636 (0.9); 2.5449 (0.7); 2.5397 (0.7); 2.5219 (0.7); 2.4921 (0.7); 2.4779 (0.7); 2.4683 (1.0); 2.4541 (1.1); 2.4455 (0.3); 2.4308 (0.3); 2.4253 (0.5); 2.4118 (0.6); 2.3878 (0.8); 2.3697 (0.6); 2.3658 (0.6); 2.3563 (0.4); 2.3474 (0.6); 2.3375 (0.6); 2.3325 (0.4); 2.3271 (0.5); 2.3180 (0.4); 2.3131 (0.4); 2.0039 (0.4); 1.8359 (0.3); 1.8234 (0.5); 1.8116 (0.6); 1.8031 (0.5); 1.7909 (0.5); 1.7793 (0.5); 1.7677 (0.4); 1.5562 (47.4) I.1-078: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.8196 (0.5); 7.8124 (3.8); 7.8072 (1.1); 7.7951 (1.2); 7.7900 (4.2); 7.7827 (0.4); 7.3591 (0.5); 7.3374 (0.6); 7.3173 (0.4); 7.1875 (0.6); 7.1706 (0.9); 7.1641 (4.3); 7.1589 (1.2); 7.1470 (1.1); 7.1417 (3.7); 7.1341 (0.3); 7.0421 (0.6); 7.0285 (0.8); 7.0072 (0.4); 4.6716 (0.8); 4.6322 (1.1); 4.2422 (1.3); 4.2277 (2.7); 4.2137 (1.5); 4.1731 (1.2); 4.1319 (1.0); 4.0736 (0.3); 3.8581 (0.4); 3.8474 (16.0); 3.6939 (0.3); 3.6832 (0.4); 3.6731 (0.6); 3.6627 (0.8); 3.6537 (0.7); 3.6411 (0.5); 3.6304 (1.3); 3.6176 (1.9); 3.6135 (2.0); 3.6027 (0.9); 3.3624 (2.6); 3.3115 (801.9); 3.2877 (13.5); 3.2626 (2.3); 3.2118 (0.4); 3.1752 (1.4); 3.1621 (1.4); 2.6786 (0.7); 2.6741 (1.2); 2.6696 (1.8); 2.6649 (1.3); 2.6606 (0.7); 2.5622 (1.1); 2.5518 (1.9); 2.5399 (1.4); 2.5230 (4.1); 2.5183 (5.3); 2.5097 (103.1); 2.5051 (228.6); 2.5005 (323.1); 2.4959 (232.4); 2.4913 (109.4); 2.3902 (0.4); 2.3715 (0.4); 2.3480 (0.6); 2.3318 (1.5); 2.3275 (2.4); 2.3228 (1.8); 2.3055 (0.6); 2.2704 (1.1); 2.2652 (0.6); 2.2496 (1.2); 2.2410 (0.8); 2.2300 (1.2); 2.2096 (0.9); 2.1987 (0.4); 2.1859 (0.4); 2.1609 (0.4); 2.1419 (0.4); 2.1291 (0.3); 2.1172 (0.4); 2.1106 (0.5); 2.0911 (0.4); 2.0857 (0.4); 2.0720 (1.1); 1.6402 (0.4); 1.6295 (0.5); 1.6173 (0.5); 1.6068 (0.4); 1.5968 (0.4); 1.5839 (0.3); 0.0081 (1.8) I.1-080: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1482 (1.1); 7.1276 (7.2); 7.1217 (6.5); 7.1159 (2.8); 7.1094 (1.1); 7.1003 (1.0); 4.6978 (1.1); 4.6803 (0.6); 4.6602 (1.1); 4.6404 (0.6); 4.0401 (1.0); 4.0332 (0.6); 4.0025 (1.0); 3.9937 (0.7); 3.7296 (0.5); 3.7193 (0.6); 3.7089 (0.6); 3.6982 (0.6); 3.5533 (0.5); 3.4387 (11.3); 3.1677 (16.0); 2.8641 (0.6); 2.8542 (0.6); 2.8246 (0.9); 2.8148 (1.0); 2.6792 (0.6); 2.6699 (0.6); 2.6492 (0.6); 2.6394 (0.6); 2.5641 (1.0); 2.5423 (1.2); 2.5236 (1.8); 2.5187 (2.2); 2.5101 (33.5); 2.5055 (72.8); 2.5009 (101.7); 2.4962 (70.1); 2.4916 (30.6); 2.4217 (1.3); 2.4043 (0.8); 2.3737 (0.8); 2.3596 (0.7); 2.3430 (0.6); 2.3324 (0.6); 2.3277 (0.7); 2.3230 (0.6); 2.2759 (12.8); 2.2644 (1.8); 2.2545 (1.8); 2.2380 (1.5); 2.2100 (0.6); 2.1434 (0.6); 2.1311 (0.5); 2.1249 (0.6); 2.1188 (0.5); 2.1135 (0.6); 2.0994 (0.9); 2.0835 (0.6); 1.6971 (0.6); 1.6515 (0.8); 1.5603 (2.3); 1.5530 (1.9); -0.0002 (8.5) I.1-082: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4699 (1.6); 8.4559 (3.0); 8.4411 (1.6); 7.3769 (1.1); 7.3560 (2.4); 7.3303 (4.7); 7.3282 (4.6); 7.3131 (6.4); 7.3089 (11.2); 7.2963 (3.3); 7.2916 (8.8); 7.2494 (3.7); 7.2465 (3.9); 7.2324 (16.0); 7.2124 (9.7); 7.1939 (1.4); 7.1867 (2.5); 7.1831 (2.6); 7.1706 (2.6); 7.1625 (1.5); 7.1536 (1.3); 7.1502 (1.4); 7.0799 (2.5); 7.0635 (3.4); 7.0444 (1.8); 4.7432 (3.9); 4.7038 (4.6); 4.2954 (1.0); 4.2805 (1.0); 4.2579 (4.8); 4.2411 (12.0); 4.2261 (5.0); 4.2003 (4.7); 4.1884 (1.1); 3.8472 (0.8); 3.8358 (1.6); 3.8257 (2.3); 3.8153 (2.8); 3.8055 (2.3); 3.7948 (1.7); 3.7840 (0.8); 3.3773 (0.6); 3.3248 (216.2); 3.2761 (1.0); 2.6743 (0.6); 2.6697 (0.9); 2.6650 (0.6); 2.6087 (3.2); 2.5975 (3.2); 2.5736 (3.9); 2.5624 (3.9); 2.5230 (2.3); 2.5097 (54.9); 2.5052 (116.5); 2.5006 (160.4); 2.4960 (112.7); 2.4915 (51.7); 2.4555 (0.8); 2.4024 (0.9); 2.3790 (1.3); 2.3597 (2.8); 2.3372 (2.8); 2.3275 (1.2); 2.3181 (2.5); 2.2862 (5.6); 2.2739 (2.7); 2.2637 (6.6); 2.2505 (6.1); 2.2292 (3.6); 2.2213 (1.8); 2.2085 (1.7); 2.1620 (1.2); 2.1429 (2.0); 2.1305 (1.4); 2.1235 (1.3); 2.1190 (1.7); 2.1114 (2.4); 2.0996 (0.9); 2.0918 (1.4); 2.0874 (1.8); 2.0675 (0.7); 1.7986 (1.0); 1.7867 (1.5); 1.7753 (2.0); 1.7652 (1.8); 1.7543 (1.7); 1.7436 (1.9); 1.7326 (1.1); 1.7199 (0.8); -0.0002 (13.6) I.1-083: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2319 (0.8); 7.2130 (1.8); 7.1942 (1.2); 7.0829 (1.0); 7.0641 (0.8); 7.0176 (1.8); 6.9881 (0.8); 4.6556 (1.2); 4.6173 (1.3); 4.0613 (1.2); 4.0234 (1.1); 3.7337 (0.7); 3.7231 (0.7); 3.7128 (0.6); 3.7021 (0.5); 3.5530 (16.0); 3.3290 (35.8); 2.7590 (0.8); 2.7487 (0.8); 2.7191 (1.1); 2.7088 (1.0); 2.6709 (0.7); 2.5460 (0.5); 2.5410 (0.6); 2.5242 (1.0); 2.5195 (2.0); 2.5108 (38.5); 2.5063 (84.9); 2.5017 (118.5); 2.4971 (84.1); 2.4926 (38.4); 2.4609 (1.2); 2.4479 (0.5); 2.4391 (1.2); 2.4214 (1.0); 2.4059 (0.8); 2.3993 (1.0); 2.3877 (0.5); 2.3329 (0.6); 2.3285 (0.8); 2.3020 (0.6); 2.2844 (9.6); 2.2641 (0.8); 2.2358 (0.5); 2.1325 (0.6); 1.7011 (0.6); 0.0080 (0.6); -0.0002 (21.7); -0.0085 (0.7) I.1-084: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2602 (57.9); 7.2110 (1.0); 7.1922 (2.4); 7.1734 (1.5); 7.1096 (25.3); 7.0586 (1.3); 7.0396 (1.0); 6.9693 (2.0); 6.9526 (1.2); 6.9326 (1.0); 5.2824 (0.6); 4.7082 (1.7); 4.6707 (2.0); 4.1098 (1.8); 4.0722 (1.6); 3.9416 (0.6); 3.9310 (0.7); 3.9209 (1.0); 3.9109 (0.7); 3.9003 (0.7); 3.5034 (0.8); 3.4857 (1.2); 3.4706 (1.1); 3.4649 (0.6); 3.4532 (0.6); 3.4474 (1.1); 3.4328 (1.2); 3.4156 (0.7); 2.7431 (1.9); 2.7257 (3.8); 2.7084 (1.8); 2.4892 (1.2); 2.4778 (1.3); 2.4616 (0.9); 2.4533 (1.4); 2.4418 (2.1); 2.4192 (0.8); 2.4118 (0.9); 2.3974 (1.0); 2.3876 (1.1); 2.3734 (1.2); 2.3448 (0.6); 2.3267 (12.5); 2.3213 (16.0); 2.1998 (0.7); 2.1866 (0.5); 2.1758 (0.6); 2.1673 (0.9); 2.1625 (0.6); 2.1430 (0.6); 2.0473 (1.5); 2.0259 (1.5); 2.0113 (1.3); 1.9899 (1.3); 1.7553 (0.5); 1.7442 (0.5); 1.7413 (0.6); 1.7306 (0.6); 1.7210 (0.6); 1.7177 (0.5); 1.7082 (0.6); 1.6974 (0.5); -0.0002 (15.0) I.1-085: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9206 (0.9); 7.3532 (0.9); 7.3373 (0.6); 7.3318 (0.9); 7.2077 (0.5); 7.2037 (0.6); 7.1949 (0.5); 7.1910 (0.6); 7.1878 (1.0); 7.1840 (1.0); 7.1751 (0.9); 7.1714 (1.0); 7.1675 (0.6); 7.1635 (0.6); 7.1546 (0.5); 7.1509 (0.6); 7.0766 (1.0); 7.0606 (1.3); 7.0574 (1.2); 7.0412 (0.7); 4.7386 (1.5); 4.6988 (1.7); 4.2400 (1.9); 4.2006 (1.6); 3.8045 (0.6); 3.7941 (0.8); 3.7838 (1.1); 3.7737 (0.8); 3.7633 (0.6); 3.3076 (49.6); 2.8956 (0.6); 2.8783 (1.6); 2.8613 (1.7); 2.8458 (1.5); 2.8284 (1.5); 2.8120 (1.4); 2.7942 (0.6); 2.5308 (1.4); 2.5229 (1.3); 2.5185 (2.5); 2.5096 (26.9); 2.5050 (59.5); 2.5004 (84.1); 2.4958 (59.9); 2.4912 (26.4); 2.3598 (1.1); 2.3406 (1.0); 2.3368 (1.1); 2.3272 (0.6); 2.3179 (1.0); 2.2882 (0.9); 2.2746 (1.1); 2.2641 (1.3); 2.2507 (1.3); 2.2465 (0.6); 2.2217 (2.1); 2.2090 (0.8); 2.1999 (1.6); 2.1867 (1.3); 2.1652 (1.3); 2.1271 (0.8); 2.1149 (0.6); 2.1032 (0.7); 2.0956 (0.9); 2.0910 (0.6); 2.0762 (0.5); 2.0714 (0.9); 1.7676 (0.6); 1.7566 (0.8); 1.7468 (0.6); 1.7355 (0.6); 1.7249 (0.7); 1.6672 (0.6); 1.6504 (1.2); 1.6336 (1.5); 1.6169 (1.2); 1.6000 (0.6); 0.8217 (16.0); 0.8049 (15.4); -0.0002 (8.6) I.1-086: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.3971 (7.6); 7.3790 (5.0); 7.3751 (4.6); 7.3584 (7.2); 7.3546 (7.8); 7.3484 (4.0); 7.3385 (4.9); 7.3330 (7.7); 7.3287 (6.4); 7.3122 (4.0); 7.3085 (3.7); 7.2099 (4.0); 7.2061 (4.0); 7.1972 (4.2); 7.1900 (7.8); 7.1864 (7.8); 7.1772 (7.6); 7.1739 (8.0); 7.1699 (4.9); 7.1660 (4.5); 7.1569 (4.1); 7.1536 (4.2); 7.0848 (7.8); 7.0687 (10.9); 7.0494 (5.5); 6.9468 (0.5); 6.8974 (7.5); 4.7474 (12.7); 4.7078 (14.6); 4.2404 (16.0); 4.2179 (0.4); 4.2007 (13.8); 3.8023 (2.5); 3.7915 (5.5); 3.7808 (7.4); 3.7706 (8.6); 3.7605 (7.5); 3.7498 (5.8); 3.7391 (2.8); 3.5598 (0.4); 3.5114 (0.4); 3.4589 (1.4); 3.4218 (1.6); 3.4080 (5.7); 3.3602 (1264.3); 3.3020 (0.4); 3.2922 (1.0); 3.2634 (1.2); 3.2470 (0.4); 3.2326 (0.3); 3.2116 (0.4); 3.1693 (2.2); 2.6794 (1.1); 2.6752 (2.3); 2.6707 (3.2); 2.6662 (2.4); 2.6618 (1.1); 2.6048 (0.4); 2.6001 (0.4); 2.5501 (1.4); 2.5455 (1.8); 2.5410 (2.0); 2.5240 (8.5); 2.5192 (12.0); 2.5106 (195.3); 2.5062 (398.9); 2.5016 (545.9); 2.4971 (389.8); 2.4926 (178.1); 2.4744 (16.3); 2.4633 (14.3); 2.4284 (0.4); 2.4105 (3.2); 2.3914 (4.0); 2.3876 (3.9); 2.3686 (9.0); 2.3494 (8.2); 2.3458 (7.5); 2.3379 (2.0); 2.3327 (3.4); 2.3274 (9.0); 2.3030 (0.4); 2.2872 (6.5); 2.2738 (7.6); 2.2631 (9.8); 2.2498 (9.8); 2.2321 (3.1); 2.2212 (5.4); 2.2083 (5.6); 2.1802 (12.7); 2.1658 (4.5); 2.1579 (12.8); 2.1452 (14.5); 2.1345 (5.2); 2.1227 (15.3); 2.1154 (8.3); 2.1107 (4.6); 2.1037 (2.8); 2.0958 (4.4); 2.0912 (5.6); 2.0716 (3.2); 1.7780 (3.3); 1.7662 (4.8); 1.7548 (6.8); 1.7444 (5.6); 1.7339 (5.5); 1.7231 (5.9); 1.7121 (3.8); 1.6993 (2.6) I.1-087: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.5856 (2.2); 8.3724 (6.0); 7.3845 (3.1); 7.3633 (6.6); 7.3372 (6.3); 7.3175 (3.3); 7.2148 (3.8); 7.1953 (6.8); 7.1823 (6.8); 7.1618 (3.8); 7.0942 (2.6); 7.0802 (7.6); 7.0643 (7.4); 7.0453 (3.5); 4.7768 (3.5); 4.7369 (11.2); 4.6970 (8.8); 4.2390 (10.4); 4.1995 (9.5); 3.8528 (16.0); 3.8078 (14.7); 3.7971 (15.2); 3.7870 (15.8); 3.7764 (13.9); 3.1683 (6.6); 2.8096 (2.7); 2.7991 (2.9); 2.7719 (3.7); 2.7612 (3.8); 2.6747 (4.4); 2.6701 (6.0); 2.6658 (4.1); 2.5791 (115.5); 2.5404 (41.5); 2.5236 (16.2); 2.5189 (24.6); 2.5102 (357.0); 2.5057 (776.9); 2.5010 (1082.2); 2.4964 (752.8); 2.4919 (337.9); 2.4648 (7.9); 2.4539 (9.2); 2.4293 (9.1); 2.4186 (8.3); 2.4028 (6.4); 2.3865 (8.1); 2.3655 (14.1); 2.3543 (29.4); 2.3323 (7.1); 2.3276 (10.4); 2.2978 (4.6); 2.2845 (5.8); 2.2734 (8.1); 2.2606 (7.2); 2.2490 (3.8); 2.2318 (4.8); 2.2194 (4.2); 2.1713 (3.4); 2.1577 (7.3); 2.1368 (9.1); 2.1223 (9.1); 2.1010 (7.9); 2.0731 (2.6); 1.7782 (2.2); 1.7661 (2.9); 1.7541 (4.5); 1.7418 (4.2); 1.7222 (4.4); 0.0081 (7.5); -0.0002 (245.9); -0.0086 (6.7) I.1-088: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9528 (0.9); 7.1430 (1.8); 7.1228 (7.4); 7.1092 (8.3); 7.0886 (2.1); 4.6659 (1.9); 4.6279 (2.2); 4.0115 (2.2); 3.9736 (2.0); 3.7157 (0.7); 3.7046 (0.9); 3.6942 (1.0); 3.6841 (0.9); 3.6731 (0.8); 3.3815 (4.2); 3.3663 (9.3); 3.3512 (8.0); 3.1683 (0.8); 3.1147 (0.8); 3.1083 (0.9); 3.1001 (2.2); 3.0932 (2.0); 3.0857 (2.1); 3.0786 (1.9); 3.0711 (0.8); 3.0631 (0.8); 2.6691 (0.5); 2.5226 (0.9); 2.5178 (1.4); 2.5092 (31.9); 2.5046 (68.2); 2.5000 (97.1); 2.4954 (68.6); 2.4908 (31.4); 2.4749 (2.3); 2.4637 (2.0); 2.4507 (0.7); 2.3641 (0.6); 2.3458 (1.1); 2.3268 (1.6); 2.3225 (1.3); 2.3036 (0.9); 2.2756 (16.0); 2.2597 (1.1); 2.2462 (1.2); 2.2355 (1.3); 2.2220 (1.3); 2.2044 (0.6); 2.1936 (0.7); 2.1803 (0.7); 2.1403 (1.7); 2.1176 (1.7); 2.1058 (1.4); 2.0832 (1.4); 2.0710 (0.6); 2.0421 (0.8); 2.0295 (0.6); 2.0179 (0.7); 2.0102 (0.9); 1.9909 (0.5); 1.9860 (0.8); 1.7164 (0.6); 1.7056 (0.8); 1.6956 (0.7); 1.6844 (0.7); 1.6737 (0.7); 0.0080 (0.8); -0.0002 (29.7); -0.0085 (0.9) I.1-089: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.8770 (6.5); 7.8843 (0.6); 7.8775 (4.7); 7.8727 (1.6); 7.8557 (5.1); 7.8490 (0.6); 7.2984 (1.2); 7.2768 (1.3); 7.1347 (4.9); 7.1289 (2.8); 7.1128 (6.2); 7.1065 (8.3); 7.0941 (8.0); 7.0734 (1.8); 6.9279 (1.4); 6.9062 (1.3); 5.3173 (1.5); 4.6472 (2.2); 4.6090 (2.4); 4.3686 (0.8); 4.3583 (2.3); 4.3489 (2.8); 4.3399 (1.9); 4.3303 (0.6); 4.3198 (0.9); 4.3090 (1.0); 4.2860 (2.5); 4.2755 (3.1); 4.2653 (1.4); 4.1537 (0.7); 4.1427 (1.1); 4.1315 (0.6); 4.0484 (2.3); 4.0106 (2.0); 3.7273 (0.7); 3.7165 (1.1); 3.7066 (1.3); 3.6956 (1.1); 3.6853 (0.8); 3.3234 (251.7); 3.2069 (12.7); 3.1674 (6.2); 2.7875 (1.2); 2.7773 (1.2); 2.7477 (1.5); 2.7375 (1.5); 2.6704 (0.7); 2.6662 (0.5); 2.5102 (44.1); 2.5058 (92.5); 2.5013 (126.9); 2.4968 (90.5); 2.4924 (42.3); 2.4664 (1.7); 2.4557 (0.7); 2.4483 (1.3); 2.4376 (0.6); 2.4268 (1.6); 2.4108 (0.7); 2.3863 (1.2); 2.3686 (1.0); 2.3452 (0.8); 2.3281 (0.8); 2.2594 (16.0); 2.2459 (1.4); 2.2321 (1.3); 2.2150 (0.5); 2.2041 (0.8); 2.1909 (0.8); 2.1358 (0.7); 2.1230 (0.6); 2.1038 (0.9); 2.0796 (0.7); 1.7160 (0.7); 1.7043 (0.9); 1.6935 (0.8); 1.6837 (0.8); 1.6725 (0.8); 1.6602 (0.6); -0.0002 (5.5) I.1-090: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2264 (1.5); 8.1026 (5.0); 7.3780 (2.4); 7.3742 (2.4); 7.3577 (5.2); 7.3535 (5.7); 7.3321 (5.7); 7.3114 (2.9); 7.3077 (2.9); 7.2081 (3.3); 7.2041 (3.5); 7.1952 (3.4); 7.1882 (6.2); 7.1842 (6.4); 7.1755 (5.8); 7.1718 (6.5); 7.1677 (3.9); 7.1638 (3.8); 7.1551 (3.2); 7.1511 (3.4); 7.0772 (6.1); 7.0611 (8.3); 7.0419 (4.3); 5.8065 (3.2); 5.7932 (7.2); 5.7804 (5.9); 5.7675 (8.2); 5.7635 (4.0); 5.7543 (3.9); 5.7502 (8.7); 5.7373 (6.9); 5.7245 (8.7); 5.7112 (3.8); 5.1305 (4.3); 5.1261 (13.8); 5.1217 (14.7); 5.1173 (4.9); 5.0875 (4.0); 5.0831 (12.3); 5.0786 (12.9); 5.0742 (4.5); 5.0607 (5.2); 5.0567 (14.4); 5.0525 (13.4); 5.0485 (4.6); 5.0350 (4.8); 5.0310 (13.4); 5.0269 (12.8); 5.0229 (4.2); 4.7416 (9.7); 4.7019 (11.2); 4.2382 (12.1); 4.1985 (10.5); 3.8243 (2.0); 3.8132 (4.1); 3.8028 (5.8); 3.7926 (7.3); 3.7824 (5.8); 3.7722 (4.3); 3.7611 (2.0); 3.7060 (0.8); 3.6836 (3.4); 3.6792 (8.0); 3.6746 (9.0); 3.6698 (10.4); 3.6654 (16.0); 3.6609 (15.9); 3.6563 (10.8); 3.6517 (9.9); 3.6472 (8.5); 3.6428 (3.4); 3.6205 (0.9); 3.4150 (2.1); 3.3183 (241.7); 3.1678 (2.0); 2.6739 (2.0); 2.6694 (2.8); 2.6647 (2.1); 2.5597 (8.6); 2.5482 (8.7); 2.5244 (13.4); 2.5180 (10.9); 2.5095 (164.1); 2.5049 (354.0); 2.5003 (494.5); 2.4957 (343.6); 2.4911 (154.5); 2.4061 (2.6); 2.3871 (3.2); 2.3646 (7.2); 2.3449 (6.4); 2.3316 (2.7); 2.3269 (4.0); 2.3223 (7.4); 2.2878 (5.6); 2.2745 (6.7); 2.2637 (8.3); 2.2504 (9.2); 2.2462 (14.5); 2.2327 (3.4); 2.2246 (11.8); 2.2110 (10.6); 2.1896 (8.9); 2.1552 (3.0); 2.1359 (5.4); 2.1313 (2.9); 2.1237 (3.9); 2.1166 (3.1); 2.1119 (4.4); 2.1043 (6.1); 2.0999 (3.6); 2.0926 (2.4); 2.0849 (3.5); 2.0804 (4.6); 2.0712 (1.4); 2.0607 (2.1); 1.7829 (2.5); 1.7705 (3.8); 1.7596 (5.1); 1.7495 (4.3); 1.7386 (4.1); 1.7279 (4.5); 1.7165 (2.8); 1.7041 (2.0); 0.0080 (4.8); -0.0002 (171.8); -0.0085 (4.9); -0.1496 (0.6) I.1-091: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0877 (0.8); 7.4625 (3.8); 7.1364 (1.6); 7.1164 (4.3); 7.0942 (4.7); 7.0738 (1.6); 4.6580 (1.2); 4.6198 (1.4); 4.0077 (3.4); 3.9948 (3.4); 3.9802 (5.1); 3.9622 (4.0); 3.9437 (1.8); 3.7060 (0.6); 3.6959 (0.7); 3.6856 (0.6); 3.4138 (12.6); 2.5224 (1.0); 2.5177 (1.5); 2.5091 (23.8); 2.5045 (52.1); 2.4999 (71.8); 2.4953 (50.3); 2.4908 (22.8); 2.4700 (1.2); 2.4589 (1.1); 2.3271 (1.0); 2.3085 (0.7); 2.2854 (0.7); 2.2734 (10.3); 2.2553 (0.6); 2.2418 (0.7); 2.2312 (0.8); 2.2177 (0.8); 2.1694 (0.9); 2.1419 (1.0); 2.1196 (1.0); 2.1074 (0.9); 2.0851 (0.9); 2.0646 (16.0); 2.0405 (0.5); 2.0088 (0.6); 1.6987 (0.5); 1.3094 (4.5); 1.2913 (9.8); 1.2731 (4.4); 0.0080 (0.7); -0.0002 (22.1); -0.0085 (0.6) I.1-092: 1H-NMR (400.1 MHz, d6-DMSO): δ= 18.0164 (1.4); 13.3388 (1.8); 13.3093 (1.5); 7.8999 (16.0); 7.8951 (13.8); 7.8905 (8.8); 7.8828 (8.6); 7.7086 (4.5); 7.6871 (5.7); 7.6099 (1.4); 7.5926 (1.7); 7.5876 (1.9); 7.5620 (6.7); 7.5419 (10.4); 7.5217 (4.5); 7.3354 (1.4); 7.1419 (1.9); 7.1186 (1.5); 4.2575 (1.3); 4.2364 (1.7); 4.2203 (1.3); 4.0887 (1.6); 3.8133 (7.7); 3.5541 (9.2); 3.5127 (1.4); 3.4113 (2.2); 3.3672 (6.0); 3.3127 (3071.8); 3.2892 (66.0); 3.2581 (7.5); 3.2125 (2.2); 3.1757 (5.8); 3.1626 (6.1); 2.7009 (1.6); 2.6743 (7.0); 2.6700 (10.2); 2.6656 (7.9); 2.5995 (1.6); 2.5653 (2.4); 2.5232 (16.2); 2.5184 (27.4); 2.5100 (581.6); 2.5055 (1273.4); 2.5010 (1795.9); 2.4965 (1309.0); 2.4919 (630.4); 2.4379 (6.1); 2.4325 (5.1); 2.4073 (3.1); 2.3922 (2.7); 2.3518 (1.6); 2.3320 (8.0); 2.3279 (10.8); 2.3233 (7.8); 2.2795 (1.4); 2.2680 (1.7); 2.0730 (6.6); 0.0077 (3.3) I.1-093: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.6303 (1.0); 8.2012 (1.0); 8.1780 (1.1); 8.1230 (1.4); 8.0991 (1.2); 7.2096 (7.8); 7.1772 (1.5); 7.1585 (2.3); 7.1247 (3.5); 7.1063 (1.5); 4.7672 (2.4); 4.7291 (2.7); 4.3938 (1.0); 4.3727 (0.9); 4.3050 (0.5); 4.2252 (0.7); 4.2095 (1.0); 4.1892 (0.7); 4.0958 (1.7); 4.0562 (1.6); 3.6843 (1.5); 3.3181 (22.0); 2.6699 (0.7); 2.6273 (1.9); 2.6092 (4.5); 2.5904 (4.5); 2.5710 (2.0); 2.5395 (3.4); 2.5039 (105.7); 2.5005 (106.7); 2.3994 (1.7); 2.3775 (3.1); 2.3554 (2.2); 2.3213 (1.1); 2.2741 (1.2); 2.2475 (1.4); 2.2170 (0.8); 2.0651 (1.0); 2.0343 (1.3); 2.0102 (1.1); 1.8554 (1.0); 1.7756 (1.8); 1.3771 (0.6); 1.2714 (0.7); 1.2563 (1.0); 1.2385 (1.5); 1.1748 (1.3); 1.1561 (2.1); 1.1403 (6.2); 1.1217 (10.5); 1.1030 (5.2); 0.8480 (12.1); 0.8308 (16.0); 0.8139 (4.4); -0.0002 (1.3) I.1-094: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.1497 (0.9); 7.1292 (5.7); 7.1211 (6.3); 7.1142 (1.7); 7.1099 (1.4); 7.1001 (1.1); 4.6731 (1.3); 4.6352 (1.4); 4.0500 (1.5); 4.0118 (1.3); 3.8004 (0.4); 3.7903 (0.5); 3.7782 (0.6); 3.7680 (0.5); 3.7581 (0.4); 3.5537 (1.0); 3.3067 (99.6); 3.2991 (22.8); 3.2827 (8.7); 3.1157 (16.0); 3.0904 (0.8); 3.0816 (0.8); 3.0472 (1.0); 3.0383 (1.0); 2.8596 (1.2); 2.7968 (1.1); 2.7738 (1.0); 2.7535 (0.9); 2.7306 (0.8); 2.6741 (0.5); 2.6696 (0.7); 2.6650 (0.6); 2.6594 (2.0); 2.5736 (0.7); 2.5230 (1.7); 2.5184 (2.4); 2.5096 (37.7); 2.5051 (83.8); 2.5006 (118.0); 2.4960 (87.2); 2.4916 (42.7); 2.4704 (0.8); 2.4488 (0.6); 2.4442 (0.6); 2.4260 (0.8); 2.4041 (0.7); 2.3841 (0.5); 2.3365 (0.3); 2.3319 (0.6); 2.3274 (0.9); 2.3229 (0.6); 2.2752 (12.0); 2.2631 (0.9); 2.2497 (0.8); 2.2381 (0.8); 2.2331 (0.4); 2.2081 (0.5); 2.1972 (0.6); 2.1764 (0.3); 2.1573 (0.5); 2.1452 (0.4); 2.1380 (0.3); 2.1325 (0.4); 2.1257 (0.6); 2.1012 (0.4); 1.7143 (0.5); 1.7036 (0.4); 1.6922 (0.6); 1.6825 (0.6); 1.6723 (0.4); 1.6596 (0.4); 0.0000 (1.0) I.1-095: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5205 (0.6); 7.3304 (3.0); 7.3275 (5.3); 7.3236 (2.3); 7.3144 (3.3); 7.3101 (14.1); 7.3066 (7.6); 7.2947 (4.5); 7.2913 (11.2); 7.2616 (106.7); 7.2527 (5.8); 7.2493 (3.7); 7.2398 (1.9); 7.2343 (6.8); 7.2282 (1.6); 7.2193 (1.2); 7.2160 (2.1); 7.2119 (1.2); 7.1788 (9.8); 7.1750 (12.6); 7.1580 (9.3); 7.1173 (1.0); 7.1073 (1.5); 7.1021 (1.3); 7.0926 (3.5); 7.0801 (2.3); 7.0768 (2.4); 7.0740 (2.7); 7.0672 (3.0); 7.0646 (2.9); 7.0595 (1.6); 7.0496 (3.7); 7.0450 (7.6); 7.0380 (9.4); 7.0350 (6.1); 7.0294 (10.4); 7.0193 (4.9); 7.0085 (0.8); 7.0021 (0.7); 6.9976 (0.6); 5.4089 (2.2); 4.8403 (4.6); 4.8368 (4.5); 4.8016 (5.2); 4.7980 (5.1); 4.2210 (6.7); 4.1822 (6.0); 3.9311 (1.1); 3.9200 (2.3); 3.9090 (2.8); 3.8985 (3.2); 3.8890 (2.8); 3.8781 (2.3); 3.8670 (1.1); 3.5569 (0.9); 3.5405 (2.8); 3.5231 (5.7); 3.5112 (6.2); 3.5083 (6.2); 3.4964 (5.7); 3.4911 (3.1); 3.4795 (2.8); 3.4626 (0.9); 2.8151 (8.1); 2.7978 (16.0); 2.7805 (7.4); 2.5736 (4.6); 2.5627 (4.6); 2.5376 (5.4); 2.5267 (5.2); 2.5042 (1.0); 2.4846 (1.3); 2.4811 (1.2); 2.4610 (3.5); 2.4416 (3.2); 2.4380 (3.0); 2.4187 (3.0); 2.4067 (3.4); 2.3920 (3.8); 2.3826 (4.6); 2.3681 (4.6); 2.3640 (1.7); 2.3492 (1.2); 2.3397 (2.0); 2.3253 (2.0); 2.2579 (1.7); 2.2389 (2.8); 2.2341 (1.6); 2.2253 (2.0); 2.2198 (1.7); 2.2149 (2.3); 2.2063 (3.1); 2.2013 (1.8); 2.1960 (1.2); 2.1871 (1.8); 2.1821 (2.4); 2.1631 (1.2); 2.1082 (5.8); 2.0858 (5.7); 2.0722 (5.1); 2.0498 (4.9); 1.8087 (1.5); 1.7974 (1.7); 1.7946 (1.9); 1.7838 (2.2); 1.7741 (2.1); 1.7709 (1.8); 1.7647 (1.7); 1.7614 (2.1); 1.7504 (1.8); 1.7411 (1.5); 1.7381 (1.3); 1.7265 (1.2); 1.6036 (6.9); 0.0079 (1.1); -0.0002 (33.8); -0.0085 (0.9) I.1-096: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1263 (1.9); 7.1059 (7.1); 7.0921 (7.6); 7.0715 (1.9); 6.9333 (3.9); 6.9103 (1.7); 6.7949 (3.1); 6.7748 (2.3); 4.6540 (1.9); 4.6160 (2.2); 4.3312 (1.2); 4.3206 (3.2); 4.3099 (3.2); 4.2999 (1.4); 4.0953 (2.9); 4.0839 (4.4); 4.0725 (2.3); 4.0428 (2.2); 4.0046 (1.9); 3.7191 (0.6); 3.7086 (1.0); 3.6982 (1.1); 3.6877 (1.0); 3.6772 (0.7); 3.3256 (163.1); 2.7850 (1.3); 2.7750 (1.3); 2.7453 (1.7); 2.7354 (1.6); 2.6703 (0.6); 2.5099 (34.5); 2.5056 (71.2); 2.5012 (96.6); 2.4967 (68.4); 2.4924 (31.6); 2.4628 (1.9); 2.4407 (1.7); 2.4233 (1.8); 2.4011 (1.8); 2.3819 (1.1); 2.3638 (0.9); 2.3583 (0.8); 2.3402 (0.8); 2.3279 (0.6); 2.2630 (15.3); 2.2426 (1.2); 2.2288 (1.2); 2.2117 (0.6); 2.1905 (15.6); 2.1248 (0.7); 2.1121 (0.6); 2.1001 (0.6); 2.0940 (0.8); 2.0737 (0.8); 2.0685 (0.8); 2.0560 (16.0); 1.7078 (0.6); 1.6962 (0.8); 1.6853 (0.7); 1.6756 (0.7); 1.6641 (0.7); -0.0002 (6.5) I.1-097: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2750 (2.0); 8.2700 (2.5); 7.6771 (1.2); 7.6708 (1.4); 7.6565 (1.6); 7.6502 (1.8); 7.5218 (0.7); 7.5013 (0.6); 7.4833 (2.4); 7.4628 (2.0); 7.3544 (0.7); 7.3334 (0.8); 7.3127 (0.5); 7.1858 (0.7); 7.1728 (0.8); 7.1560 (0.5); 7.0954 (0.7); 7.0792 (0.9); 4.7492 (1.0); 4.7097 (1.2); 4.5538 (1.6); 4.5216 (0.6); 4.4838 (2.3); 4.4599 (2.4); 4.4220 (0.7); 4.2795 (1.2); 4.2402 (1.1); 3.8949 (0.6); 3.8855 (0.7); 3.8733 (0.6); 3.8641 (0.6); 3.5216 (4.3); 3.1666 (0.6); 2.8917 (16.0); 2.8742 (0.8); 2.8433 (1.0); 2.8333 (1.0); 2.7526 (3.9); 2.6704 (0.6); 2.5962 (1.0); 2.5741 (1.0); 2.5552 (0.8); 2.5329 (0.8); 2.5238 (1.3); 2.5192 (1.9); 2.5105 (33.8); 2.5059 (74.9); 2.5013 (105.5); 2.4967 (74.0); 2.4921 (33.0); 2.4549 (0.5); 2.4312 (0.8); 2.4139 (0.7); 2.3281 (0.7); 2.3236 (0.6); 2.2685 (0.5); 2.2555 (0.9); 2.2437 (0.9); 2.2162 (1.4); 2.2074 (1.0); 2.1996 (0.9); 2.1813 (0.9); 1.7027 (0.6); 0.0080 (1.3); -0.0002 (48.4); -0.0085 (1.4) I.1-098: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2967 (0.6); 8.2773 (0.6); 7.1459 (0.6); 7.1252 (3.8); 7.1179 (3.5); 7.1133 (1.3); 7.0967 (0.6); 4.6628 (0.8); 4.6247 (0.8); 4.0256 (0.8); 3.9880 (0.6); 3.5388 (0.8); 2.5351 (0.5); 2.5107 (4.7); 2.5061 (10.3); 2.5015 (14.4); 2.4969 (10.1); 2.4923 (4.9); 2.4796 (0.5); 2.4719 (0.8); 2.4522 (0.7); 2.2762 (6.9); 2.0270 (16.0) I.1-099: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9665 (0.6); 7.9501 (0.6); 7.3617 (0.6); 7.3579 (0.7); 7.3359 (0.7); 7.3317 (0.6); 7.1908 (0.7); 7.1872 (0.7); 7.1781 (0.7); 7.1747 (0.7); 7.0763 (0.5); 7.0600 (0.8); 4.7313 (0.7); 4.6909 (0.8); 4.2301 (1.4); 4.1901 (1.2); 4.0786 (0.6); 4.0619 (0.7); 4.0456 (0.6); 3.7653 (0.6); 3.7550 (0.5); 3.5995 (1.3); 3.5639 (16.0); 3.5626 (15.0); 2.5196 (0.6); 2.5109 (9.7); 2.5064 (21.4); 2.5017 (29.9); 2.4971 (20.7); 2.4925 (9.2); 2.4816 (1.0); 2.4754 (0.7); 2.4707 (0.7); 2.4644 (1.2); 2.4478 (1.0); 2.4432 (1.3); 2.4361 (0.8); 2.4272 (1.8); 2.4104 (1.0); 2.3955 (1.2); 2.3923 (1.3); 2.3784 (1.3); 2.3749 (1.4); 2.3544 (1.0); 2.3406 (0.5); 2.3369 (0.9); 2.3316 (0.7); 2.2648 (0.8); 2.2541 (0.6); 2.1673 (0.6); 2.1502 (0.7); 2.1460 (0.7); 2.1326 (0.8); 2.1287 (0.7); 2.1153 (0.9); 2.1114 (1.0); 2.0938 (0.8); 2.0804 (0.5); 1.7412 (0.5); 1.7306 (0.6); 1.0617 (6.8); 1.0450 (6.7); -0.0002 (6.2) I.1-100: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9170 (0.8); 7.1447 (1.4); 7.1243 (6.4); 7.1124 (7.1); 7.0916 (1.5); 4.6721 (1.7); 4.6341 (1.8); 4.0192 (1.8); 3.9813 (1.7); 3.7170 (0.6); 3.7060 (0.8); 3.6954 (0.9); 3.6855 (0.8); 3.6746 (0.7); 3.5626 (4.8); 2.9018 (0.5); 2.8848 (1.3); 2.8679 (1.4); 2.8524 (1.1); 2.8481 (1.0); 2.8331 (1.3); 2.8166 (1.2); 2.5204 (1.3); 2.5100 (9.1); 2.5054 (17.6); 2.5008 (24.4); 2.4962 (17.1); 2.4917 (7.9); 2.4869 (1.9); 2.4754 (1.4); 2.3460 (0.9); 2.3274 (0.9); 2.3232 (0.9); 2.3040 (0.7); 2.2756 (13.3); 2.2559 (1.0); 2.2457 (1.1); 2.2317 (1.0); 2.2038 (0.6); 2.1900 (0.5); 2.1466 (1.3); 2.1239 (1.3); 2.1123 (1.2); 2.0896 (1.1); 2.0461 (0.6); 2.0219 (0.6); 2.0145 (0.7); 1.9902 (0.6); 1.7078 (0.6); 1.6973 (0.6); 1.6865 (0.6); 1.6729 (0.7); 1.6555 (1.1); 1.6388 (1.3); 1.6220 (1.0); 1.6052 (0.5); 0.8248 (16.0); 0.8081 (15.4) I.1-101: 1H-NMR (400.1 MHz, CDCl3): δ= 7.3082 (0.4); 7.2935 (0.7); 7.2896 (0.9); 7.2866 (0.7); 7.2832 (0.3); 7.2743 (1.2); 7.2719 (1.1); 7.2701 (1.0); 7.2694 (1.0); 7.2652 (9.4); 7.2636 (9.2); 7.2612 (38.5); 7.2569 (1.0); 7.2560 (0.9); 7.2551 (0.9); 7.2535 (0.7); 7.2528 (0.7); 7.0240 (1.2); 7.0043 (1.1); 6.9972 (0.4); 6.9799 (0.4); 6.9760 (0.6); 6.9575 (2.0); 6.9546 (1.8); 6.9348 (1.5); 5.9943 (0.5); 4.7366 (1.3); 4.6981 (1.5); 4.2094 (1.4); 4.1709 (1.2); 4.0121 (0.5); 4.0037 (0.6); 4.0002 (0.4); 3.9920 (0.9); 3.9834 (0.5); 3.9801 (0.5); 3.9718 (0.5); 3.7384 (0.4); 3.7006 (16.0); 3.6478 (2.1); 3.5074 (0.3); 3.5032 (0.5); 3.4884 (1.2); 3.4736 (1.6); 3.4708 (1.4); 3.4579 (1.0); 3.4558 (1.2); 3.4410 (0.5); 2.5367 (0.4); 2.5336 (0.4); 2.5191 (2.0); 2.5146 (1.2); 2.5053 (3.1); 2.5032 (2.9); 2.4898 (3.0); 2.4699 (0.9); 2.4655 (1.2); 2.4537 (1.6); 2.4398 (0.7); 2.4302 (1.0); 2.4157 (0.9); 2.4118 (0.4); 2.3874 (0.6); 2.3730 (0.4); 2.2989 (0.4); 2.2797 (0.6); 2.2749 (0.4); 2.2663 (0.5); 2.2605 (0.4); 2.2556 (0.5); 2.2473 (0.7); 2.2422 (0.4); 2.2279 (0.4); 2.2231 (0.5); 2.1428 (1.1); 2.1222 (1.1); 2.1063 (1.0); 2.0857 (0.9); 2.0430 (1.1); 1.8157 (0.3); 1.8044 (0.4); 1.8014 (0.4); 1.7920 (0.5); 1.7828 (0.5); 1.7808 (0.5); 1.7777 (0.4); 1.7715 (0.4); 1.7687 (0.5); 1.7664 (0.4); 1.7595 (0.4); 1.7573 (0.4); 1.7481 (0.4); 1.5714 (7.4); 1.2763 (0.3); 1.2585 (0.8); 1.2406 (0.3); 0.0082 (0.5); 0.0040 (3.4); 0.0026 (3.5) I.1-102: 1H-NMR (400.6 MHz, d6-DMSO): δ= 7.3795 (5.3); 7.3676 (1.7); 7.3605 (14.0); 7.3496 (2.0); 7.3425 (15.5); 7.3414 (16.0); 7.3348 (8.3); 7.3305 (13.4); 7.3259 (10.3); 7.3149 (3.2); 7.3097 (5.0); 7.3059 (3.3); 7.2841 (10.2); 7.2800 (14.6); 7.2018 (6.5); 7.1979 (10.2); 7.1839 (5.1); 7.1799 (7.9); 7.1763 (4.2); 5.6573 (2.8); 4.6623 (0.6); 4.6264 (9.3); 4.5875 (10.5); 4.1509 (10.5); 4.1119 (9.0); 3.7883 (1.7); 3.7772 (3.5); 3.7662 (4.5); 3.7574 (4.6); 3.7550 (4.7); 3.7463 (4.4); 3.7353 (3.5); 3.7244 (1.7); 3.1845 (0.8); 3.1677 (0.9); 2.7072 (0.5); 2.6761 (0.8); 2.6716 (1.1); 2.6670 (1.3); 2.6533 (6.7); 2.6425 (6.8); 2.6152 (8.2); 2.6044 (7.8); 2.5252 (4.0); 2.5205 (5.7); 2.5119 (47.2); 2.5074 (96.1); 2.5028 (130.0); 2.4982 (89.2); 2.4936 (39.4); 2.4240 (1.9); 2.4055 (2.5); 2.4002 (2.4); 2.3821 (5.4); 2.3638 (4.4); 2.3586 (4.0); 2.3406 (4.2); 2.3299 (1.1); 2.3253 (0.8); 2.3201 (0.8); 2.3023 (0.7); 2.2891 (4.0); 2.2752 (4.9); 2.2649 (6.0); 2.2510 (6.3); 2.2426 (8.1); 2.2338 (2.9); 2.2201 (8.2); 2.2096 (4.4); 2.2045 (6.8); 2.1820 (6.4); 2.1672 (2.5); 2.1485 (3.5); 2.1432 (2.3); 2.1357 (2.9); 2.1299 (2.5); 2.1240 (3.0); 2.1171 (4.0); 2.1116 (2.6); 2.1058 (1.8); 2.0981 (2.5); 2.0926 (2.9); 2.0859 (0.8); 2.0740 (2.0); 1.7250 (2.1); 1.7120 (3.0); 1.7010 (4.0); 1.6903 (3.3); 1.6802 (3.2); 1.6768 (2.6); 1.6691 (3.4); 1.6583 (2.2); 1.6447 (1.5); 0.0080 (1.3); -0.0002 (40.5); -0.0085 (1.2) I.1-103: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9518 (0.5); 7.9324 (0.5); 7.1448 (1.3); 7.1245 (4.8); 7.1104 (4.2); 7.0898 (1.2); 4.6514 (0.9); 4.6133 (1.0); 4.0834 (0.6); 4.0658 (0.7); 4.0476 (0.6); 4.0150 (1.0); 3.9773 (0.9); 3.7087 (1.1); 3.7025 (1.1); 3.6979 (1.2); 3.6890 (1.2); 3.6788 (1.0); 3.6717 (0.8); 3.6606 (0.6); 3.5587 (16.0); 2.5104 (6.4); 2.5058 (14.0); 2.5012 (19.6); 2.4966 (13.6); 2.4920 (6.0); 2.4826 (0.5); 2.4651 (0.6); 2.4604 (0.9); 2.4575 (0.7); 2.4448 (1.5); 2.4371 (0.6); 2.4270 (1.5); 2.4230 (1.6); 2.4116 (0.7); 2.4057 (1.0); 2.3974 (1.1); 2.3934 (1.0); 2.3804 (1.2); 2.3763 (1.1); 2.3594 (0.7); 2.3558 (0.5); 2.3422 (0.8); 2.3390 (0.6); 2.3165 (0.6); 2.2756 (10.3); 2.2476 (0.6); 2.2387 (0.5); 2.2251 (0.6); 2.0862 (0.6); 2.0645 (1.0); 2.0517 (0.7); 2.0422 (0.6); 2.0304 (1.1); 2.0074 (0.8); 1.0636 (3.9); 1.0607 (4.6); 1.0468 (4.0); 1.0439 (4.5); -0.0002 (5.4) I.1-104: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5231 (0.6); 7.5199 (0.6); 7.2643 (96.1); 7.2611 (98.2); 7.1288 (0.4); 7.1156 (0.9); 7.1039 (1.4); 7.0955 (1.2); 7.0877 (1.6); 7.0791 (1.8); 7.0607 (6.4); 7.0531 (6.2); 7.0415 (2.5); 7.0002 (0.5); 6.9972 (0.6); 4.9006 (2.7); 4.8619 (3.0); 4.7252 (0.9); 4.7167 (1.0); 4.6977 (1.8); 4.6892 (2.0); 4.6711 (1.0); 4.6622 (1.0); 4.2537 (3.3); 4.2144 (3.0); 3.9096 (0.5); 3.8986 (0.9); 3.8881 (1.4); 3.8769 (1.7); 3.8671 (1.6); 3.8576 (1.1); 3.8466 (0.6); 2.7503 (1.7); 2.7432 (1.8); 2.7407 (1.7); 2.7121 (2.1); 2.7048 (2.1); 2.6878 (0.4); 2.5606 (0.6); 2.5439 (0.8); 2.5186 (1.9); 2.4974 (1.7); 2.4771 (1.5); 2.4433 (1.1); 2.4280 (1.4); 2.4189 (1.6); 2.4037 (2.3); 2.3879 (2.5); 2.3852 (2.6); 2.3792 (1.4); 2.3642 (2.9); 2.3495 (1.8); 2.3468 (1.8); 2.3268 (1.6); 2.3240 (1.6); 2.3076 (0.6); 2.2900 (1.0); 2.2826 (0.7); 2.2738 (1.2); 2.2693 (1.0); 2.2657 (1.0); 2.2573 (1.4); 2.2496 (1.0); 2.2362 (1.0); 2.2335 (1.0); 2.2159 (0.5); 1.9461 (1.5); 1.9169 (1.6); 1.8478 (0.7); 1.8366 (1.2); 1.8243 (1.5); 1.8123 (2.0); 1.8040 (2.1); 1.7920 (2.4); 1.7792 (1.7); 1.6939 (3.0); 1.6616 (3.0); 1.5546 (28.1); 1.5526 (28.0); 1.5217 (0.5); 1.4822 (1.1); 1.4749 (1.1); 1.4678 (1.1); 1.3812 (0.9); 1.3515 (1.8); 1.3233 (1.1); 1.0874 (0.6); 1.0567 (1.5); 1.0302 (1.7); 1.0226 (1.4); 0.9976 (0.8); 0.9920 (0.7); 0.9810 (1.0); 0.9683 (0.6); 0.9510 (2.6); 0.9106 (14.7); 0.9022 (16.0); 0.8970 (15.2); 0.8944 (14.7); 0.8872 (12.8); 0.8848 (13.2); 0.8449 (1.4); 0.8152 (0.5); 0.7507 (12.5); 0.7333 (12.2); 0.0032 (42.7) I.1-105: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.3773 (1.5); 7.3837 (3.2); 7.3797 (3.5); 7.3633 (6.9); 7.3591 (7.6); 7.3531 (4.0); 7.3434 (4.9); 7.3372 (7.6); 7.3332 (6.5); 7.3171 (4.0); 7.3130 (3.9); 7.2100 (4.2); 7.2060 (4.4); 7.1973 (4.4); 7.1933 (5.3); 7.1901 (8.0); 7.1863 (8.4); 7.1773 (7.7); 7.1738 (8.5); 7.1698 (5.2); 7.1658 (5.1); 7.1570 (4.5); 7.1533 (4.8); 7.0952 (8.3); 7.0792 (11.0); 7.0598 (5.5); 4.7425 (12.4); 4.7031 (14.4); 4.2541 (16.0); 4.2145 (13.8); 3.7884 (2.7); 3.7780 (5.1); 3.7672 (7.1); 3.7579 (7.7); 3.7473 (6.9); 3.7367 (5.4); 3.7262 (2.2); 3.6385 (0.9); 3.3168 (89.6); 3.1651 (0.6); 2.7041 (12.6); 2.6939 (12.6); 2.6793 (1.6); 2.6747 (3.0); 2.6701 (4.8); 2.6644 (17.6); 2.6541 (15.4); 2.5618 (1.4); 2.5573 (1.7); 2.5528 (1.2); 2.5403 (1.6); 2.5236 (9.4); 2.5189 (14.8); 2.5102 (203.5); 2.5056 (437.7); 2.5010 (608.9); 2.4964 (428.8); 2.4919 (192.2); 2.4614 (2.0); 2.4563 (2.4); 2.4518 (2.2); 2.4469 (3.4); 2.4290 (4.0); 2.4192 (2.3); 2.4052 (10.4); 2.3986 (17.6); 2.3877 (7.9); 2.3805 (8.1); 2.3766 (17.3); 2.3650 (4.4); 2.3588 (13.7); 2.3498 (2.1); 2.3368 (14.3); 2.3279 (4.2); 2.3232 (2.8); 2.2887 (6.0); 2.2757 (6.7); 2.2642 (11.0); 2.2513 (10.8); 2.2363 (1.0); 2.2229 (9.2); 2.2199 (9.6); 2.2115 (6.8); 2.2059 (6.6); 2.1956 (5.9); 2.1900 (4.7); 2.1777 (7.1); 2.1712 (3.6); 2.1656 (2.7); 2.1584 (4.6); 2.1524 (4.1); 2.1340 (2.4); 2.0733 (1.0); 1.7823 (1.1); 1.7603 (3.1); 1.7547 (6.9); 1.7436 (7.0); 1.7307 (7.3); 1.7255 (4.2); 1.7198 (3.9); 1.7140 (4.9); 1.7008 (4.4); 1.6883 (2.8); 0.1461 (1.0); 0.0512 (0.6); 0.0080 (9.4); 0.0062 (3.6); -0.0002 (315.7); -0.0060 (4.4); -0.0069 (3.9); -0.0085 (9.8); - 0.0500 (1.2); -0.1495 (1.0) I.1-106: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4043 (1.2); 7.1443 (1.7); 7.1240 (7.7); 7.1120 (8.4); 7.0913 (1.8); 4.6741 (2.0); 4.6359 (2.2); 3.9988 (2.2); 3.9607 (2.0); 3.8465 (1.8); 3.8401 (2.1); 3.8362 (2.2); 3.8326 (2.4); 3.8300 (2.4); 3.8266 (2.2); 3.8227 (2.1); 3.8163 (1.8); 3.7181 (0.7); 3.7071 (1.0); 3.6970 (1.1); 3.6871 (0.9); 3.6760 (0.7); 3.3125 (77.6); 3.2621 (0.6); 3.1680 (0.8); 3.1079 (1.6); 3.1016 (3.0); 3.0958 (1.4); 2.6694 (0.7); 2.5298 (1.6); 2.5228 (1.8); 2.5182 (3.7); 2.5095 (40.9); 2.5049 (87.8); 2.5003 (121.6); 2.4957 (86.2); 2.4912 (38.5); 2.4505 (0.6); 2.3737 (0.6); 2.3517 (1.2); 2.3318 (1.6); 2.3274 (1.5); 2.3093 (0.9); 2.2763 (16.0); 2.2649 (1.2); 2.2512 (1.2); 2.2402 (1.3); 2.2270 (1.3); 2.2093 (0.6); 2.1985 (0.7); 2.1853 (0.7); 2.1613 (1.7); 2.1392 (1.7); 2.1264 (1.5); 2.1042 (1.4); 2.0717 (0.9); 2.0514 (0.8); 2.0389 (0.6); 2.0272 (0.8); 2.0196 (1.0); 1.9956 (0.8); 1.6979 (0.6); 1.6869 (0.9); 1.6767 (0.7); 1.6645 (0.7); 1.6550 (0.7); 0.0080 (0.8); - 0.0002 (27.1); -0.0086 (0.8) I.1-107: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4636 (0.6); 7.4548 (5.6); 7.4497 (1.8); 7.4378 (1.8); 7.4324 (6.3); 7.4238 (0.6); 7.1292 (2.0); 7.1086 (7.5); 7.0949 (8.0); 7.0744 (2.0); 6.9234 (0.7); 6.9147 (6.0); 6.9094 (1.9); 6.8976 (1.8); 6.8923 (5.7); 4.6476 (2.0); 4.6095 (2.3); 4.3213 (1.2); 4.3111 (3.2); 4.3015 (3.1); 4.2919 (1.6); 4.1467 (3.1); 4.1354 (4.5); 4.1244 (2.4); 4.0468 (2.3); 4.0085 (2.1); 3.7205 (0.7); 3.7102 (1.1); 3.6996 (1.2); 3.6895 (1.0); 3.6791 (0.8); 3.3486 (75.3); 2.7789 (1.3); 2.7688 (1.3); 2.7391 (1.7); 2.7290 (1.6); 2.5055 (56.9); 2.5011 (78.0); 2.4967 (56.5); 2.4758 (2.0); 2.4540 (1.8); 2.4360 (1.5); 2.4141 (1.7); 2.4048 (0.6); 2.3871 (1.2); 2.3691 (0.9); 2.3631 (0.9); 2.3455 (0.8); 2.2632 (16.0); 2.2471 (1.3); 2.2332 (1.2); 2.2053 (0.7); 2.1920 (0.7); 2.1307 (0.7); 2.1182 (0.6); 2.1123 (0.5); 2.1056 (0.6); 2.0995 (0.9); 2.0744 (0.6); 1.7090 (0.7); 1.6975 (0.8); 1.6869 (0.7); 1.6768 (0.7); 1.6654 (0.7); 1.6532 (0.5); -0.0002 (3.4) I.1-108: 1H-NMR (400.1 MHz, d6-DMSO): δ= 19.7654 (0.7); 19.7059 (0.7); 17.6711 (0.8); 17.1313 (0.7); 14.0023 (0.7); 12.6881 (0.7); 11.6932 (0.8); 8.3710 (7.3); 8.3494 (7.0); 7.4486 (0.7); 7.3835 (2.1); 7.3638 (4.8); 7.3410 (4.7); 7.3190 (2.7); 7.2892 (0.8); 7.2104 (2.6); 7.1910 (5.5); 7.1789 (6.0); 7.1607 (5.7); 7.1546 (6.4); 7.1441 (8.4); 7.1390 (12.3); 7.1300 (12.0); 7.1250 (11.6); 7.1018 (15.0); 7.0957 (16.0); 7.0781 (12.2); 7.0590 (3.6); 6.6020 (0.7); 4.9535 (3.4); 4.9384 (4.4); 4.7582 (7.4); 4.7184 (8.7); 4.2744 (4.6); 4.2540 (5.1); 4.2354 (4.1); 4.2140 (4.2); 3.8711 (1.9); 3.8605 (2.8); 3.8499 (3.7); 3.8371 (3.8); 3.8264 (3.4); 3.8173 (3.0); 3.8057 (1.6); 3.5814 (0.7); 3.5223 (0.7); 3.4939 (0.8); 3.4290 (1.7); 3.3282 (392.0); 3.2339 (1.8); 3.2191 (1.6); 3.1935 (1.2); 3.1687 (10.9); 2.8908 (2.3); 2.7728 (1.8); 2.7438 (3.8); 2.7307 (7.0); 2.7181 (6.0); 2.7034 (6.3); 2.6704 (6.4); 2.6468 (1.5); 2.6102 (0.9); 2.5963 (1.2); 2.5828 (3.6); 2.5732 (5.3); 2.5653 (5.2); 2.5497 (7.2); 2.5408 (10.4); 2.5061 (759.5); 2.5017 (1025.9); 2.4973 (785.6); 2.4215 (3.1); 2.3994 (3.1); 2.3813 (3.8); 2.3736 (4.1); 2.3555 (4.9); 2.3290 (7.1); 2.3245 (5.5); 2.3106 (2.9); 2.2989 (3.8); 2.2867 (5.8); 2.2815 (5.9); 2.2704 (6.1); 2.2609 (6.3); 2.2476 (7.6); 2.2348 (5.5); 2.2263 (4.3); 2.2145 (4.0); 2.1923 (2.1); 2.1687 (2.4); 2.1575 (3.1); 2.1395 (3.1); 2.1243 (2.4); 2.1006 (1.8); 2.0718 (3.2); 2.0201 (0.7); 1.9080 (0.7); 1.8353 (8.2); 1.8253 (9.3); 1.8157 (9.2); 1.7441 (1.9); 1.7206 (3.0); 1.7063 (4.1); 1.6799 (3.3); 1.6650 (3.2); 1.6491 (3.1); 1.6271 (3.9); 1.6062 (2.9); 0.1451 (0.8); 0.0082 (5.3) I.1-109: 1H-NMR (400.1 MHz, CDCl3): δ= 7.2620 (55.2); 7.2122 (0.6); 7.1295 (0.4); 7.1162 (0.8); 7.1047 (1.5); 7.0951 (0.9); 7.0869 (1.6); 7.0803 (1.6); 7.0760 (1.1); 7.0621 (6.5); 7.0523 (6.0); 7.0443 (2.1); 7.0383 (1.7); 4.9128 (1.9); 4.9094 (2.0); 4.9008 (0.5); 4.8741 (2.2); 4.8705 (2.2); 4.8622 (0.6); 4.8585 (0.5); 4.7174 (1.0); 4.7065 (1.0); 4.6968 (0.5); 4.6902 (2.0); 4.6793 (2.0); 4.6630 (1.1); 4.6520 (1.0); 4.2507 (0.7); 4.2430 (3.0); 4.2042 (2.7); 3.8924 (0.5); 3.8821 (0.9); 3.8716 (1.3); 3.8612 (1.4); 3.8499 (1.2); 3.8395 (0.9); 3.8293 (0.5); 2.7500 (0.4); 2.7401 (0.5); 2.7321 (2.0); 2.7227 (2.0); 2.7117 (0.5); 2.7016 (0.6); 2.6944 (2.6); 2.6850 (2.5); 2.5609 (0.6); 2.5425 (0.7); 2.5367 (0.7); 2.5180 (1.8); 2.4996 (1.4); 2.4940 (1.4); 2.4757 (1.4); 2.4378 (1.2); 2.4237 (1.4); 2.4183 (0.6); 2.4132 (1.7); 2.4018 (3.3); 2.3845 (0.8); 2.3794 (2.9); 2.3702 (1.1); 2.3642 (2.4); 2.3564 (1.0); 2.3465 (0.6); 2.3416 (2.1); 2.3239 (0.4); 2.2938 (0.7); 2.2746 (1.2); 2.2696 (0.7); 2.2614 (0.9); 2.2557 (0.8); 2.2499 (0.9); 2.2421 (1.2); 2.2368 (0.9); 2.2311 (0.6); 2.2229 (0.7); 2.2173 (0.9); 2.1985 (0.5); 1.9647 (0.5); 1.9530 (1.1); 1.9456 (0.9); 1.9349 (0.7); 1.9301 (0.8); 1.9228 (1.2); 1.9005 (0.7); 1.8872 (0.8); 1.8759 (1.2); 1.8655 (0.9); 1.8538 (0.9); 1.8431 (1.1); 1.8324 (0.8); 1.8240 (0.6); 1.8182 (0.9); 1.8073 (1.0); 1.8005 (1.1); 1.7896 (1.4); 1.7831 (1.3); 1.7722 (1.0); 1.7653 (1.0); 1.7547 (0.4); 1.7484 (0.4); 1.6921 (2.3); 1.6850 (1.9); 1.6660 (2.3); 1.6597 (2.4); 1.6516 (1.6); 1.6446 (0.6); 1.5676 (16.8); 1.5181 (0.4); 1.5113 (0.4); 1.5033 (0.5); 1.4953 (0.6); 1.4896 (0.7); 1.4816 (0.8); 1.4737 (0.8); 1.4654 (0.9); 1.4572 (0.7); 1.4510 (0.6); 1.4438 (0.6); 1.4357 (0.5); 1.3961 (0.5); 1.3883 (0.8); 1.3810 (0.6); 1.3583 (1.4); 1.3384 (0.6); 1.3303 (1.0); 1.3228 (0.7); 1.0850 (0.6); 1.0596 (1.1); 1.0531 (1.3); 1.0284 (1.6); 1.0206 (1.2); 0.9958 (1.6); 0.9893 (0.6); 0.9785 (0.3); 0.9657 (2.4); 0.9488 (0.6); 0.9376 (2.2); 0.9101 (16.0); 0.8988 (15.3); 0.8938 (15.8); 0.8814 (14.5); 0.8607 (0.4); 0.8484 (1.1); 0.8441 (1.1); 0.8186 (0.4); 0.7478 (13.9); 0.7304 (13.5); 0.0082 (0.7); 0.0000 (23.9) I.1-111: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9089 (0.8); 7.1441 (1.6); 7.1238 (6.1); 7.1098 (6.6); 7.0892 (1.6); 4.6676 (1.6); 4.6296 (1.8); 4.0134 (1.9); 3.9756 (1.6); 3.7175 (0.6); 3.7065 (0.8); 3.6961 (0.9); 3.6863 (0.8); 3.6753 (0.6); 3.4499 (16.0); 3.0047 (0.7); 2.9942 (0.8); 2.9870 (1.5); 2.9768 (1.5); 2.9727 (1.5); 2.9628 (1.4); 2.9551 (0.7); 2.9455 (0.7); 2.5231 (0.7); 2.5184 (1.0); 2.5098 (15.6); 2.5052 (33.6); 2.5006 (47.3); 2.4960 (32.7); 2.4915 (14.9); 2.4650 (1.4); 2.4539 (1.4); 2.3429 (0.9); 2.3233 (1.0); 2.3010 (0.8); 2.2756 (13.0); 2.2670 (1.2); 2.2529 (1.0); 2.2425 (1.1); 2.2287 (1.0); 2.2007 (0.6); 2.1870 (0.5); 2.1187 (1.4); 2.0962 (1.3); 2.0843 (1.2); 2.0618 (1.2); 2.0463 (0.6); 2.0222 (0.6); 2.0147 (0.8); 1.9905 (0.6); 1.6966 (0.7); 1.6865 (0.6); 1.6748 (0.5); 1.6646 (0.6); 1.4013 (1.5); 1.3832 (3.0); 1.3651 (3.3); 1.3471 (1.7); 0.8387 (5.4); 0.8203 (11.1); 0.8017 (4.7) I.1-112: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.8315 (1.3); 8.3271 (0.8); 8.3077 (1.5); 8.2885 (0.9); 7.5321 (0.9); 7.5210 (1.0); 7.5131 (1.0); 7.5019 (1.1); 7.3409 (0.9); 7.3286 (2.6); 7.3084 (3.1); 7.1670 (0.7); 7.1516 (0.8); 7.1346 (0.8); 7.1158 (2.7); 7.0659 (0.7); 7.0628 (0.7); 7.0482 (1.5); 7.0334 (1.2); 7.0303 (1.0); 7.0253 (0.8); 6.9860 (1.3); 6.9836 (1.4); 6.9666 (2.0); 6.9495 (1.6); 6.9326 (0.6); 6.9300 (0.6); 4.7106 (0.6); 4.6801 (0.8); 4.6716 (0.8); 4.6404 (0.8); 4.5032 (0.7); 4.4909 (0.7); 4.4827 (0.8); 4.4703 (0.7); 4.1974 (0.8); 4.1574 (0.7); 4.1352 (0.9); 4.0958 (0.8); 3.6900 (0.5); 3.6808 (0.7); 3.6703 (0.8); 3.6601 (0.8); 3.6508 (0.6); 3.4760 (16.0); 3.1850 (0.6); 3.1738 (0.6); 3.1679 (0.7); 3.1491 (0.9); 3.1384 (0.8); 3.0043 (1.1); 2.9815 (1.1); 2.9679 (0.8); 2.9455 (0.8); 2.6701 (0.6); 2.5341 (0.7); 2.5237 (1.5); 2.5189 (2.5); 2.5103 (33.0); 2.5057 (71.6); 2.5011 (99.7); 2.4965 (69.4); 2.4919 (31.1); 2.4730 (0.8); 2.3278 (0.6); 2.2630 (0.6); 2.2436 (0.9); 2.2244 (0.5); 2.2103 (0.7); 2.1970 (0.7); 2.1878 (1.3); 2.1754 (1.9); 2.1636 (1.4); 2.1518 (1.3); 2.1406 (0.6); 2.0727 (0.5); -0.0002 (5.4) I.1-113: 1H-NMR (400.0 MHz, d6-DMSO): δ= 16.6531 (1.0); 16.4917 (1.2); 10.8380 (7.6); 8.3084 (7.5); 8.2888 (7.4); 7.5218 (8.8); 7.5025 (9.6); 7.3612 (2.6); 7.3371 (5.5); 7.3285 (13.2); 7.3083 (15.1); 7.2952 (2.2); 7.1709 (3.0); 7.1473 (4.9); 7.1350 (5.2); 7.1264 (3.7); 7.1167 (16.0); 7.1112 (12.4); 7.0658 (5.2); 7.0456 (9.4); 7.0281 (6.7); 7.0010 (4.2); 6.9845 (6.2); 6.9696 (9.2); 6.9671 (10.0); 6.9498 (11.2); 6.9324 (5.1); 6.9301 (4.5); 4.6804 (6.9); 4.6414 (7.6); 4.5027 (2.9); 4.4907 (3.8); 4.4816 (4.3); 4.4703 (4.2); 4.4612 (3.1); 4.4480 (2.3); 4.1353 (7.8); 4.0954 (7.4); 3.6820 (3.4); 3.6711 (4.3); 3.6609 (4.4); 3.6489 (3.8); 3.6396 (3.4); 3.4468 (130.7); 3.4028 (10.7); 3.3984 (10.2); 3.3937 (10.1); 3.3891 (9.3); 3.3843 (7.9); 3.3794 (5.9); 3.3739 (4.2); 3.3683 (3.6); 3.3634 (3.4); 3.3583 (3.8); 3.3542 (3.6); 3.3498 (3.4); 3.3244 (4.1); 3.3127 (2.1); 3.3078 (1.2); 3.3004 (1.2); 3.2956 (2.7); 3.2906 (3.3); 3.2855 (2.8); 3.2799 (2.2); 3.2338 (2.1); 3.2291 (2.1); 3.2236 (2.1); 3.2187 (2.8); 3.2143 (4.8); 3.2076 (3.4); 3.1850 (4.2); 3.1722 (5.5); 3.1678 (7.6); 3.1475 (6.0); 3.1365 (5.6); 3.1015 (1.3); 3.0458 (1.3); 3.0411 (1.4); 3.0048 (5.7); 2.9815 (5.6); 2.9676 (5.3); 2.9456 (4.1); 2.6705 (3.7); 2.6655 (2.5); 2.6364 (1.1); 2.5478 (1.9); 2.5103 (226.6); 2.5058 (476.1); 2.5012 (643.3); 2.4966 (445.4); 2.4920 (197.1); 2.4729 (9.5); 2.4609 (5.4); 2.4563 (7.0); 2.4518 (7.8); 2.4470 (5.2); 2.4426 (2.8); 2.4060 (1.9); 2.3817 (1.7); 2.3280 (3.9); 2.3233 (3.0); 2.3039 (2.5); 2.2817 (3.4); 2.2621 (4.9); 2.2411 (5.5); 2.2188 (4.4); 2.2100 (6.2); 2.1877 (9.8); 2.1757 (9.4); 2.1639 (5.8); 2.1523 (8.2); 2.1326 (2.3); 2.1217 (3.2); 2.1100 (2.3); 2.0729 (2.2); 2.0162 (1.3); 1.9686 (1.5); 1.9483 (3.3); 1.9348 (2.8); 1.9243 (2.8); 1.9158 (4.2); 1.8909 (3.6); 1.8859 (2.2); 1.8811 (1.8); 1.8721 (2.0); 1.8575 (1.2); 1.8273 (1.2); 1.8158 (1.2); 1.7611 (2.1); 1.7379 (1.4); 1.7304 (1.3); 1.7086 (3.0); 1.7038 (3.0); 1.6981 (3.3); 1.6875 (1.9); 1.6635 (5.3); 1.6538 (2.8); 1.6417 (2.7); 1.6305 (2.2); 1.6066 (2.5); 1.6019 (2.6); 1.5973 (2.6); 1.4791 (1.1); -0.0002 (19.8) I.1-114: 1H-NMR (400.0 MHz, d6-DMSO): δ= 11.8093 (5.6); 7.5295 (2.0); 7.5212 (2.0); 7.5135 (3.2); 7.5050 (2.9); 7.5030 (3.0); 7.4960 (1.7); 7.4873 (2.2); 7.2311 (1.2); 7.2266 (1.1); 7.2153 (11.8); 7.2119 (6.5); 7.2060 (5.7); 7.1994 (7.2); 7.1964 (10.7); 7.1857 (0.6); 7.1800 (0.7); 7.0726 (2.1); 6.9448 (2.0); 4.7058 (3.8); 4.6662 (4.4); 4.2413 (4.7); 4.2012 (4.0); 3.9643 (4.0); 3.8630 (0.7); 3.8528 (1.5); 3.8422 (2.1); 3.8322 (2.4); 3.8220 (2.0); 3.8116 (1.5); 3.8020 (0.7); 3.3888 (70.2); 3.2101 (64.7); 3.1681 (16.0); 2.7502 (3.2); 2.7397 (3.2); 2.7120 (4.0); 2.7015 (3.8); 2.6788 (0.8); 2.6742 (1.6); 2.6695 (2.4); 2.6650 (1.6); 2.6602 (0.8); 2.5554 (0.5); 2.5507 (0.8); 2.5460 (0.8); 2.5398 (1.5); 2.5231 (6.2); 2.5183 (9.1); 2.5097 (130.5); 2.5052 (276.0); 2.5005 (376.9); 2.4959 (262.8); 2.4913 (118.3); 2.4408 (4.5); 2.4188 (4.7); 2.4022 (4.7); 2.3807 (5.7); 2.3597 (1.6); 2.3365 (0.9); 2.3319 (1.7); 2.3273 (2.3); 2.3227 (1.6); 2.3180 (0.8); 2.3083 (1.7); 2.2960 (2.0); 2.2842 (2.9); 2.2721 (2.8); 2.2553 (0.6); 2.2426 (1.9); 2.2319 (3.0); 2.2145 (2.2); 2.2028 (1.5); 2.1956 (1.2); 2.1904 (1.2); 2.1836 (2.3); 2.1715 (0.7); 2.1638 (1.3); 2.1593 (1.5); 2.1400 (0.6); 2.0719 (1.0); 1.7926 (0.8); 1.7841 (1.7); 1.7728 (1.6); 1.7622 (1.8); 1.7544 (1.9); 1.7423 (1.4); 1.7295 (1.2); 1.7181 (0.8); 0.0120 (0.6); 0.0080 (1.3); -0.0002 (46.8); -0.0085 (1.3) I.1-115: 1H-NMR (400.1 MHz, d6-DMSO): δ= 12.3254 (1.7); 7.2129 (1.0); 7.2059 (1.9); 7.1962 (12.0); 7.1791 (12.6); 7.1742 (12.5); 7.1639 (3.2); 7.1573 (11.6); 7.1476 (2.0); 7.1404 (1.0); 4.5857 (8.6); 4.5461 (10.4); 4.2417 (0.3); 4.1978 (11.6); 4.1583 (9.7); 3.9660 (0.8); 3.8065 (1.9); 3.7955 (3.4); 3.7847 (5.0); 3.7753 (5.5); 3.7649 (5.0); 3.7544 (3.9); 3.7433 (1.8); 3.5809 (0.4); 3.5573 (0.5); 3.3351 (12.0); 3.1710 (16.0); 2.6799 (8.9); 2.6695 (9.2); 2.6399 (11.2); 2.6295 (10.9); 2.5248 (0.8); 2.5201 (1.2); 2.5114 (25.4); 2.5068 (56.9); 2.5022 (80.2); 2.4976 (57.3); 2.4930 (26.5); 2.4431 (2.2); 2.4260 (2.7); 2.4174 (2.3); 2.4018 (6.5); 2.3845 (5.3); 2.3778 (5.2); 2.3714 (12.2); 2.3625 (4.5); 2.3496 (11.3); 2.3315 (9.8); 2.3254 (5.4); 2.3098 (12.1); 2.3011 (7.8); 2.2871 (7.6); 2.2706 (0.9); 2.2597 (4.4); 2.2474 (7.5); 2.2323 (3.4); 2.2301 (4.0); 2.2230 (1.5); 2.2189 (3.8); 2.2134 (3.0); 2.2086 (2.1); 2.2057 (2.5); 2.2015 (4.4); 2.1947 (2.8); 2.1893 (1.9); 2.1820 (3.1); 2.1754 (2.8); 2.1577 (1.7); 1.7551 (2.2); 1.7447 (4.1); 1.7332 (4.5); 1.7267 (2.9); 1.7223 (3.7); 1.7154 (4.8); 1.7084 (2.8); 1.7022 (4.3); 1.6907 (2.9); 1.6769 (1.9); 0.0082 (0.5); 0.0000 (16.4) I.1-116: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1474 (1.7); 7.1294 (2.0); 7.1162 (6.1); 7.1099 (8.8); 7.0968 (11.4); 7.0768 (1.8); 6.8372 (5.8); 6.8156 (4.9); 4.6496 (2.1); 4.6111 (2.2); 4.3323 (0.5); 4.3134 (1.3); 4.3022 (3.4); 4.2907 (3.8); 4.2803 (1.4); 4.1070 (3.1); 4.0961 (5.0); 4.0844 (2.4); 4.0504 (2.4); 4.0124 (2.0); 3.7272 (0.7); 3.7168 (1.1); 3.7061 (1.2); 3.6952 (1.1); 3.6844 (0.7); 3.3485 (2.7); 3.3230 (697.4); 3.2993 (40.8); 3.2006 (0.8); 3.1749 (0.5); 2.7825 (1.3); 2.7724 (1.4); 2.7426 (1.7); 2.7324 (1.8); 2.6703 (1.4); 2.5566 (1.4); 2.5376 (4.8); 2.5100 (89.9); 2.5057 (185.1); 2.5012 (250.3); 2.4968 (175.9); 2.4755 (2.2); 2.4535 (2.0); 2.4353 (1.9); 2.4140 (2.0); 2.3891 (1.4); 2.3718 (1.1); 2.3482 (1.0); 2.3280 (1.6); 2.2817 (1.3); 2.2633 (16.0); 2.2460 (1.3); 2.2318 (1.3); 2.2146 (0.5); 2.2041 (0.8); 2.1906 (0.8); 2.1522 (0.6); 2.1325 (0.7); 2.1206 (0.7); 2.1023 (1.0); 2.0732 (0.8); 1.7145 (0.7); 1.7035 (0.8); 1.6922 (0.8); 1.6714 (0.8); 1.6600 (0.5); 1.1683 (0.8); 1.1563 (6.1); 1.1373 (13.1); 1.1183 (5.9); -0.0002 (13.3) I.1-117: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3045 (2.6); 7.2993 (1.0); 7.2858 (4.0); 7.2829 (3.9); 7.2644 (3.3); 7.1313 (1.9); 7.1106 (7.7); 7.0983 (8.2); 7.0777 (1.8); 6.9612 (1.5); 6.9429 (2.7); 6.9279 (4.8); 6.9085 (4.1); 4.6502 (2.0); 4.6120 (2.2); 4.3313 (1.3); 4.3203 (3.7); 4.3089 (4.0); 4.2986 (1.5); 4.1439 (3.3); 4.1326 (5.3); 4.1211 (2.4); 4.0531 (2.3); 4.0150 (2.0); 3.7295 (0.7); 3.7186 (1.1); 3.7083 (1.2); 3.6983 (1.1); 3.6875 (0.7); 3.3626 (76.8); 2.7840 (1.3); 2.7738 (1.4); 2.7443 (1.8); 2.7340 (1.7); 2.5234 (1.1); 2.5100 (25.0); 2.5056 (52.1); 2.5011 (71.0); 2.4967 (50.4); 2.4923 (23.2); 2.4805 (2.2); 2.4587 (1.8); 2.4407 (1.5); 2.4330 (0.6); 2.4189 (1.7); 2.4072 (0.8); 2.3908 (1.2); 2.3728 (0.9); 2.3669 (0.8); 2.3493 (0.8); 2.2632 (16.0); 2.2475 (1.3); 2.2337 (1.2); 2.2056 (0.8); 2.1925 (0.8); 2.1371 (0.7); 2.1243 (0.6); 2.1188 (0.5); 2.1124 (0.6); 2.1056 (0.9); 2.0863 (0.5); 2.0810 (0.6); 1.7191 (0.7); 1.7073 (0.9); 1.6964 (0.7); 1.6871 (0.7); 1.6754 (0.8); 1.6635 (0.5) I.1-118: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3718 (1.6); 7.3679 (1.7); 7.3514 (3.5); 7.3476 (3.8); 7.3415 (2.0); 7.3316 (2.4); 7.3257 (3.9); 7.3050 (2.0); 7.3016 (1.9); 7.2046 (2.2); 7.2008 (2.3); 7.1919 (2.3); 7.1848 (4.1); 7.1810 (4.3); 7.1721 (4.0); 7.1685 (4.3); 7.1645 (2.6); 7.1605 (2.5); 7.1516 (2.2); 7.1482 (2.3); 7.0849 (4.2); 7.0690 (5.7); 7.0496 (2.8); 4.7002 (6.5); 4.6608 (7.8); 4.2973 (8.4); 4.2575 (7.0); 3.9112 (1.3); 3.8999 (2.5); 3.8912 (3.3); 3.8802 (4.7); 3.8711 (2.9); 3.8606 (2.5); 3.8492 (1.1); 3.4027 (98.0); 3.3419 (2.7); 3.3248 (4.7); 3.3164 (3.7); 3.3078 (3.4); 3.2998 (6.0); 3.2827 (3.4); 3.2515 (1.1); 3.2345 (2.0); 3.2221 (4.4); 3.2047 (13.6); 3.1875 (16.0); 3.1778 (3.8); 3.1703 (7.4); 3.1613 (5.2); 3.1444 (2.8); 2.6709 (5.0); 2.6594 (4.5); 2.6309 (5.8); 2.6190 (5.5); 2.5234 (3.1); 2.5187 (4.6); 2.5101 (70.3); 2.5055 (151.7); 2.5009 (210.5); 2.4963 (146.2); 2.4917 (65.3); 2.4619 (2.2); 2.4441 (2.5); 2.4354 (1.9); 2.4204 (5.1); 2.4040 (8.7); 2.3975 (4.0); 2.3841 (7.5); 2.3642 (4.8); 2.3438 (4.6); 2.3323 (1.0); 2.3277 (1.4); 2.3231 (1.0); 2.2797 (3.1); 2.2669 (3.4); 2.2555 (5.3); 2.2426 (5.3); 2.2269 (0.7); 2.2142 (4.1); 2.2071 (6.0); 2.1924 (3.2); 2.1811 (2.8); 2.1753 (2.3); 2.1629 (4.0); 2.1571 (1.9); 2.1511 (1.3); 2.1438 (2.3); 2.1385 (2.4); 2.1193 (1.2); 2.0717 (0.9); 1.8589 (0.6); 1.8458 (1.3); 1.8289 (3.7); 1.8174 (4.6); 1.8111 (5.8); 1.8009 (6.6); 1.7936 (4.8); 1.7848 (5.2); 1.7766 (2.6); 1.7690 (2.6); 1.7617 (1.4); 1.7479 (2.8); 1.7383 (2.7); 1.7319 (5.9); 1.7209 (8.6); 1.7177 (7.8); 1.7097 (5.3); 1.7003 (8.8); 1.6915 (4.0); 1.6861 (5.8); 1.6796 (3.4); 1.6677 (3.1); 1.6548 (2.0); -0.0002 (1.6) I.1-119: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1315 (1.8); 7.1110 (7.6); 7.0986 (8.1); 7.0865 (4.2); 7.0655 (4.5); 6.8231 (0.8); 6.8158 (5.6); 6.7945 (4.7); 4.6509 (2.0); 4.6127 (2.2); 4.3104 (1.2); 4.2996 (3.4); 4.2883 (3.6); 4.2781 (1.4); 4.0993 (3.1); 4.0881 (4.9); 4.0765 (2.4); 4.0507 (2.3); 4.0125 (2.0); 3.7260 (0.7); 3.7156 (1.0); 3.7052 (1.2); 3.6949 (1.1); 3.6847 (0.8); 3.5245 (4.6); 2.7822 (1.3); 2.7720 (1.3); 2.7424 (1.7); 2.7323 (1.6); 2.5101 (9.4); 2.5059 (19.2); 2.5015 (25.7); 2.4971 (18.2); 2.4759 (1.8); 2.4541 (1.7); 2.4361 (1.5); 2.4143 (1.8); 2.4077 (0.6); 2.3898 (1.1); 2.3718 (0.9); 2.3660 (0.8); 2.3482 (0.8); 2.2648 (15.6); 2.2463 (1.3); 2.2245 (16.0); 2.2046 (0.8); 2.1913 (0.8); 2.1336 (0.7); 2.1208 (0.6); 2.1150 (0.5); 2.1086 (0.6); 2.1024 (0.9); 2.0965 (0.5); 2.0829 (0.5); 2.0774 (0.6); 1.7149 (0.6); 1.7030 (0.8); 1.6919 (0.7); 1.6830 (0.7); 1.6711 (0.7); - 0.0002 (0.6) I.1-120: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.7028 (3.9); 7.3857 (0.5); 7.3819 (0.6); 7.3615 (1.4); 7.3394 (1.4); 7.3190 (0.7); 7.3154 (0.7); 7.2125 (0.6); 7.2092 (0.7); 7.1926 (1.4); 7.1892 (1.5); 7.1770 (1.5); 7.1690 (0.9); 7.1595 (0.8); 7.1564 (0.8); 7.0754 (1.4); 7.0590 (2.0); 7.0403 (1.0); 4.7263 (2.3); 4.6864 (2.7); 4.2446 (2.8); 4.2045 (2.4); 3.8459 (0.4); 3.8360 (0.9); 3.8252 (1.3); 3.8151 (1.5); 3.8046 (1.3); 3.7948 (1.0); 3.7849 (0.5); 3.3584 (3.1); 3.3400 (10.5); 3.3219 (14.3); 3.3036 (4.2); 3.1691 (10.1); 2.7798 (1.8); 2.7697 (1.8); 2.7415 (2.2); 2.7313 (2.2); 2.5231 (0.4); 2.5098 (14.4); 2.5054 (31.9); 2.5009 (45.4); 2.4964 (33.9); 2.4919 (16.8); 2.4584 (2.4); 2.4364 (2.4); 2.4203 (2.4); 2.3983 (3.2); 2.3797 (1.5); 2.3584 (1.1); 2.3278 (0.3); 2.3045 (1.0); 2.2919 (1.2); 2.2802 (1.6); 2.2677 (1.6); 2.2511 (0.4); 2.2385 (1.0); 2.2276 (1.2); 2.2229 (1.0); 2.2046 (1.2); 2.1928 (0.8); 2.1857 (0.7); 2.1805 (0.8); 2.1736 (1.3); 2.1616 (0.5); 2.1539 (0.8); 2.1495 (0.9); 2.1299 (0.4); 1.7782 (0.5); 1.7684 (1.0); 1.7570 (1.0); 1.7463 (1.1); 1.7383 (1.2); 1.7259 (0.9); 1.7143 (0.7); 1.7023 (0.4); 1.2086 (7.2); 1.1903 (16.0); 1.1719 (7.1); 0.0083 (0.3) I.1-121: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.5493 (1.1); 8.2765 (1.5); 8.2561 (1.6); 7.1739 (2.6); 7.1532 (7.5); 7.1340 (6.9); 7.1133 (2.1); 4.6775 (1.7); 4.6395 (1.9); 4.2451 (0.6); 4.2300 (0.8); 4.2106 (0.9); 4.0522 (1.8); 4.0139 (1.8); 3.7059 (1.1); 3.6965 (0.9); 3.6864 (0.7); 3.3642 (0.7); 3.3248 (153.5); 3.2909 (1.5); 3.1858 (1.3); 3.1672 (2.3); 2.8282 (0.6); 2.7570 (1.3); 2.6744 (2.9); 2.6697 (4.0); 2.6652 (2.9); 2.6057 (1.6); 2.5869 (4.0); 2.5680 (4.3); 2.5490 (1.5); 2.5231 (9.7); 2.5185 (15.2); 2.5098 (232.1); 2.5052 (507.3); 2.5006 (711.3); 2.4960 (503.2); 2.4915 (227.5); 2.4716 (5.0); 2.4670 (5.4); 2.4624 (4.1); 2.3708 (0.9); 2.3495 (1.3); 2.3320 (3.8); 2.3275 (5.2); 2.3229 (3.5); 2.3067 (1.1); 2.2713 (1.0); 2.2568 (1.1); 2.2464 (1.2); 2.2280 (1.9); 2.2053 (1.8); 2.1938 (1.5); 2.1716 (1.2); 2.0733 (1.1); 2.0078 (0.8); 1.9830 (0.7); 1.7128 (0.8); 1.6020 (0.8); 1.5881 (0.7); 1.5121 (1.2); 1.5000 (1.6); 1.4868 (1.8); 1.4655 (1.0); 1.1933 (0.9); 1.1841 (7.1); 1.1753 (1.9); 1.1652 (16.0); 1.1462 (6.9); 1.0966 (0.6); 1.0782 (1.0); 1.0601 (0.5); 0.9820 (0.6); 0.8917 (8.1); 0.8753 (7.9); 0.8255 (8.0); 0.8093 (7.7); 0.1462 (1.0); 0.0080 (9.7); -0.0002 (346.4); -0.0086 (10.6); -0.0338 (2.0); -0.1494 (1.2) I.1-122: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3683 (0.6); 7.3479 (1.4); 7.3258 (1.4); 7.3056 (0.6); 7.2030 (0.8); 7.1872 (1.5); 7.1832 (1.5); 7.1708 (1.6); 7.1626 (1.0); 7.1503 (0.9); 7.0857 (1.6); 7.0696 (2.1); 7.0501 (1.0); 4.7345 (2.2); 4.6951 (2.5); 4.6192 (0.6); 4.2853 (2.8); 4.2456 (2.4); 3.9014 (0.8); 3.8920 (1.2); 3.8815 (1.6); 3.8720 (1.2); 3.8615 (0.9); 3.3604 (1.6); 3.3239 (383.6); 3.2732 (0.9); 3.2547 (0.6); 3.2178 (4.1); 3.2098 (3.5); 3.2035 (3.9); 3.1999 (4.0); 3.1922 (3.5); 3.1784 (1.6); 3.1682 (1.7); 3.1587 (0.6); 2.7281 (1.8); 2.7166 (1.8); 2.6989 (2.8); 2.6881 (2.5); 2.6742 (3.8); 2.6694 (4.3); 2.6648 (3.0); 2.6603 (1.3); 2.5368 (1.7); 2.5229 (10.8); 2.5182 (16.4); 2.5095 (227.4); 2.5050 (496.0); 2.5003 (692.8); 2.4957 (481.1); 2.4911 (214.4); 2.4666 (2.4); 2.4506 (3.4); 2.4299 (2.8); 2.4254 (1.8); 2.4105 (2.4); 2.3898 (2.6); 2.3364 (1.5); 2.3318 (3.1); 2.3271 (4.3); 2.3225 (3.0); 2.3178 (1.4); 2.2761 (1.2); 2.2633 (1.2); 2.2517 (2.0); 2.2390 (1.8); 2.2106 (1.5); 2.2040 (2.1); 2.1897 (1.2); 2.1780 (1.0); 2.1723 (0.9); 2.1597 (1.4); 2.1401 (0.8); 2.1351 (0.9); 2.0722 (1.1); 1.6868 (1.2); 1.6756 (1.2); 1.6644 (1.0); 1.6460 (0.9); 1.6328 (0.8); 1.6204 (0.5); 1.1575 (0.8); 1.0315 (6.0); 1.0138 (14.6); 0.9960 (6.0); 0.9754 (7.1); 0.9577 (16.0); 0.9400 (6.9); 0.8308 (0.5); 0.0080 (5.1); -0.0002 (202.4); -0.0085 (6.1); -0.1497 (0.7) I.1-123: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3884 (4.8); 7.3795 (0.7); 7.3690 (14.0); 7.3502 (16.0); 7.3445 (8.1); 7.3401 (14.3); 7.3356 (10.6); 7.3245 (2.9); 7.3195 (4.9); 7.3157 (3.1); 7.2916 (10.7); 7.2875 (15.5); 7.2014 (6.8); 7.1976 (12.0); 7.1943 (12.2); 7.1838 (5.6); 7.1798 (8.5); 7.0624 (13.2); 6.9306 (6.7); 4.6605 (0.5); 4.6209 (10.1); 4.5816 (11.3); 4.1542 (11.4); 4.1281 (1.0); 4.1150 (10.0); 3.8273 (2.4); 3.8168 (4.3); 3.8062 (5.6); 3.7952 (6.2); 3.7854 (5.8); 3.7750 (4.8); 3.7646 (3.1); 3.7503 (1.7); 3.7394 (1.7); 3.7280 (1.7); 3.7191 (1.7); 3.7084 (1.7); 3.5969 (1.8); 3.1681 (1.1); 2.8244 (5.8); 2.8141 (6.1); 2.7849 (7.3); 2.7747 (7.2); 2.6746 (0.8); 2.6700 (1.1); 2.6651 (1.1); 2.5235 (0.7); 2.5187 (1.9); 2.5101 (61.4); 2.5055 (134.0); 2.5009 (188.0); 2.4963 (138.2); 2.4918 (67.5); 2.4570 (9.2); 2.4481 (3.3); 2.4345 (7.3); 2.4237 (3.7); 2.4176 (6.6); 2.4056 (6.2); 2.3952 (6.9); 2.3872 (5.9); 2.3827 (5.2); 2.3639 (4.5); 2.3411 (0.9); 2.3372 (0.8); 2.3323 (1.2); 2.3277 (1.5); 2.3230 (1.4); 2.3159 (4.1); 2.3024 (4.9); 2.2916 (6.1); 2.2783 (6.3); 2.2610 (2.2); 2.2496 (3.6); 2.2368 (3.7); 2.2035 (2.4); 2.1845 (3.8); 2.1795 (2.3); 2.1720 (3.1); 2.1656 (2.8); 2.1601 (3.3); 2.1531 (4.5); 2.1479 (3.0); 2.1414 (2.1); 2.1336 (2.8); 2.1286 (3.3); 2.1167 (0.7); 2.1094 (1.6); 2.0720 (0.7); 1.7414 (1.8); 1.7293 (3.0); 1.7180 (4.0); 1.7075 (3.6); 1.6974 (3.7); 1.6862 (3.8); 1.6751 (2.5); 1.6621 (1.7); 1.1797 (0.7); -0.0002 (5.8) I.1-124: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1459 (1.6); 7.1259 (4.8); 7.1077 (5.4); 7.1023 (1.1); 7.0871 (1.6); 4.6490 (1.4); 4.6108 (1.6); 4.0551 (1.6); 4.0387 (1.3); 4.0209 (4.3); 4.0039 (4.3); 3.9860 (1.4); 3.7248 (0.6); 3.7143 (0.8); 3.7042 (0.9); 3.6939 (0.8); 3.6834 (0.6); 3.3154 (45.4); 3.1852 (2.3); 2.7296 (1.2); 2.7194 (1.2); 2.6900 (1.6); 2.6797 (1.6); 2.5233 (1.3); 2.5186 (1.8); 2.5100 (22.8); 2.5054 (49.3); 2.5007 (68.3); 2.4961 (47.2); 2.4915 (20.7); 2.4263 (1.8); 2.4045 (1.7); 2.3940 (0.9); 2.3867 (1.4); 2.3751 (0.7); 2.3699 (0.7); 2.3649 (1.4); 2.3520 (0.6); 2.2875 (0.9); 2.2760 (11.4); 2.2631 (1.2); 2.2493 (1.0); 2.2212 (0.6); 2.2078 (0.6); 2.1496 (0.5); 2.1194 (0.6); 1.6969 (0.7); 1.6763 (0.5); 1.6649 (0.6); 1.1525 (7.1); 1.1347 (16.0); 1.1169 (7.0); -0.0002 (2.4) I.1-125: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.5747 (4.1); 7.5683 (4.3); 7.3791 (2.0); 7.3727 (1.8); 7.3569 (2.5); 7.3504 (2.4); 7.1933 (4.2); 7.1711 (3.2); 7.1252 (2.0); 7.1047 (7.4); 7.0904 (7.9); 7.0699 (2.0); 4.6527 (2.0); 4.6146 (2.3); 4.3580 (1.1); 4.3477 (2.9); 4.3382 (3.2); 4.3291 (1.7); 4.2560 (3.3); 4.2452 (3.8); 4.2342 (1.8); 4.0414 (2.3); 4.0033 (2.0); 3.7206 (0.7); 3.7099 (1.0); 3.6993 (1.2); 3.6890 (1.0); 3.6787 (0.7); 3.3295 (328.1); 3.2978 (0.6); 3.1673 (0.5); 2.7824 (1.3); 2.7724 (1.3); 2.7427 (1.7); 2.7327 (1.6); 2.6703 (0.8); 2.5099 (51.5); 2.5056 (105.7); 2.5012 (142.7); 2.4968 (101.0); 2.4926 (46.9); 2.4634 (2.0); 2.4412 (1.8); 2.4236 (1.8); 2.4017 (1.8); 2.3805 (1.2); 2.3628 (1.0); 2.3388 (1.0); 2.3328 (0.8); 2.3284 (0.9); 2.2613 (16.0); 2.2417 (1.3); 2.2279 (1.2); 2.1998 (0.7); 2.1866 (0.8); 2.1284 (0.8); 2.1158 (0.6); 2.1040 (0.6); 2.0975 (0.9); 2.0729 (0.9); 1.7164 (0.6); 1.7040 (0.8); 1.6929 (0.8); 1.6840 (0.7); 1.6721 (0.7); 1.6610 (0.5); -0.0002 (1.4) I.1-126: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2940 (1.2); 7.2719 (1.4); 7.1073 (1.8); 7.0975 (1.9); 6.8472 (1.3); 6.8251 (1.2); 4.3066 (0.7); 4.2947 (0.8); 4.1145 (0.6); 4.1033 (1.1); 4.0515 (0.5); 3.5111 (1.0); 2.5103 (2.3); 2.5059 (4.9); 2.5014 (6.6); 2.4969 (4.7); 2.4925 (2.2); 2.2609 (3.5); 1.2449 (16.0) I.1-127: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.3803 (2.0); 7.3765 (2.2); 7.3596 (4.3); 7.3560 (4.9); 7.3503 (2.7); 7.3400 (3.0); 7.3340 (4.9); 7.3303 (4.4); 7.3136 (2.5); 7.3101 (2.5); 7.2090 (2.5); 7.2052 (2.9); 7.1946 (9.0); 7.1894 (5.9); 7.1856 (5.6); 7.1761 (4.8); 7.1729 (5.4); 7.1690 (3.6); 7.1650 (3.2); 7.1559 (2.6); 7.1526 (2.8); 7.0723 (5.4); 7.0629 (16.0); 7.0566 (8.2); 7.0369 (3.8); 6.9312 (7.1); 4.7048 (8.2); 4.6648 (9.6); 4.4857 (0.3); 4.4346 (0.3); 4.3883 (0.3); 4.3790 (0.3); 4.3558 (0.3); 4.3214 (0.4); 4.3090 (0.4); 4.2590 (10.2); 4.2189 (8.7); 4.1710 (0.4); 4.1520 (0.4); 4.1467 (0.4); 4.1134 (0.4); 4.0808 (0.4); 4.0718 (0.4); 4.0420 (0.4); 4.0184 (0.4); 3.9887 (0.4); 3.9614 (0.3); 3.9413 (0.3); 3.9202 (0.4); 3.8772 (0.4); 3.8585 (1.8); 3.8483 (3.3); 3.8376 (4.6); 3.8273 (5.2); 3.8171 (4.5); 3.8069 (3.6); 3.7970 (1.7); 3.1694 (0.5); 2.8330 (6.0); 2.8230 (6.2); 2.7935 (7.6); 2.7835 (7.5); 2.6743 (0.7); 2.6696 (0.9); 2.6650 (0.7); 2.5567 (0.6); 2.5522 (0.9); 2.5495 (1.0); 2.5448 (0.8); 2.5230 (2.3); 2.5166 (9.3); 2.5098 (43.7); 2.5053 (97.0); 2.5007 (138.0); 2.4960 (106.3); 2.4916 (51.6); 2.4774 (7.1); 2.4552 (6.4); 2.4478 (2.8); 2.4286 (2.4); 2.4214 (2.2); 2.4054 (5.5); 2.3868 (4.7); 2.3829 (4.6); 2.3655 (3.1); 2.3433 (0.5); 2.3369 (0.4); 2.3322 (0.6); 2.3275 (1.0); 2.3228 (0.8); 2.3018 (3.4); 2.2894 (3.9); 2.2775 (5.8); 2.2651 (5.9); 2.2490 (0.8); 2.2359 (3.9); 2.2272 (6.8); 2.2110 (4.0); 2.1993 (3.1); 2.1927 (2.6); 2.1865 (2.3); 2.1805 (4.6); 2.1754 (2.5); 2.1684 (1.6); 2.1609 (2.6); 2.1561 (3.0); 2.1368 (1.3); 2.0710 (1.2); 1.7703 (1.8); 1.7623 (3.6); 1.7509 (3.5); 1.7401 (3.9); 1.7332 (3.8); 1.7281 (2.6); 1.7207 (3.0); 1.7080 (2.7); 1.6961 (1.5); 0.0082 (0.9) I.1-128: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1469 (2.1); 7.1261 (7.1); 7.1102 (7.6); 7.0899 (2.2); 4.6575 (2.0); 4.6196 (2.3); 4.1138 (1.7); 4.1029 (4.5); 4.0911 (4.6); 4.0808 (1.7); 4.0566 (2.4); 4.0190 (2.0); 3.7240 (0.9); 3.7131 (1.1); 3.7018 (1.2); 3.6920 (1.1); 3.6827 (0.9); 3.4783 (4.2); 3.4669 (6.9); 3.4550 (4.8); 3.4196 (41.7); 3.2278 (28.7); 2.7612 (1.3); 2.7512 (1.4); 2.7216 (1.8); 2.7114 (1.8); 2.6696 (0.6); 2.5100 (29.7); 2.5056 (61.9); 2.5012 (84.2); 2.4967 (59.5); 2.4924 (27.3); 2.4547 (1.9); 2.4326 (2.1); 2.4152 (1.6); 2.4037 (1.4); 2.3933 (1.7); 2.3859 (1.1); 2.3623 (0.8); 2.2763 (16.0); 2.2615 (1.3); 2.2479 (1.3); 2.2316 (0.6); 2.2195 (0.7); 2.2060 (0.8); 2.1495 (0.8); 2.1168 (1.0); 2.0926 (0.8); 2.0728 (0.7); 1.7116 (0.6); 1.7008 (1.0); 1.6805 (0.8); 1.6687 (0.8); 1.6583 (0.6); -0.0002 (1.6) I.1-129: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3751 (16.0); 7.1396 (1.2); 7.1196 (2.9); 7.0922 (3.1); 7.0721 (1.3); 4.6374 (0.9); 4.5992 (1.0); 4.1524 (1.2); 4.1363 (2.7); 4.1203 (1.3); 4.0416 (1.1); 4.0032 (0.9); 3.6729 (0.6); 3.4076 (8.0); 3.2032 (1.3); 3.1872 (2.7); 3.1710 (1.2); 2.7032 (0.6); 2.6930 (0.6); 2.6635 (0.8); 2.6533 (0.8); 2.5068 (9.7); 2.5024 (13.1); 2.4981 (9.3); 2.3815 (1.2); 2.3602 (1.2); 2.3420 (0.8); 2.3203 (0.7); 2.2714 (7.2); 2.2547 (0.6); 2.2406 (0.6) I.1-130: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.6935 (0.5); 7.8181 (3.9); 7.3656 (0.9); 7.3437 (0.8); 7.1954 (0.9); 7.1826 (0.9); 7.1068 (0.8); 7.0899 (1.1); 7.0717 (0.6); 4.7752 (1.1); 4.7356 (1.3); 4.2913 (1.5); 4.2517 (1.4); 3.9036 (0.6); 3.8934 (0.8); 3.8842 (0.8); 3.8722 (0.7); 3.8621 (0.6); 3.5968 (16.0); 3.3206 (69.7); 3.1858 (0.9); 3.1343 (0.7); 3.1224 (0.8); 3.1161 (2.4); 3.1041 (2.2); 3.0979 (2.2); 3.0860 (2.2); 3.0798 (0.7); 3.0679 (0.7); 2.8861 (0.6); 2.8763 (0.6); 2.8491 (0.8); 2.8389 (0.7); 2.7694 (0.8); 2.7609 (0.8); 2.6746 (0.9); 2.6699 (1.2); 2.6653 (0.8); 2.5504 (1.4); 2.5459 (1.0); 2.5402 (1.3); 2.5234 (4.2); 2.5186 (6.2); 2.5100 (67.6); 2.5054 (143.4); 2.5008 (197.1); 2.4962 (137.3); 2.4916 (61.3); 2.4690 (0.6); 2.4264 (1.0); 2.4082 (0.8); 2.4040 (0.8); 2.3869 (0.7); 2.3369 (0.5); 2.3322 (1.0); 2.3276 (1.8); 2.3231 (1.0); 2.3150 (0.7); 2.3031 (1.0); 2.2904 (1.0); 2.2615 (0.7); 2.2508 (1.1); 2.2339 (0.8); 2.2219 (0.6); 2.2154 (0.5); 2.2034 (0.8); 2.1783 (0.6); 1.8628 (0.5); 1.8517 (0.6); 1.8405 (0.6); 1.8332 (0.6); 1.8209 (0.5); 1.1937 (5.4); 1.1755 (11.2); 1.1572 (5.2); 0.0079 (1.6); -0.0002 (51.9); -0.0086 (1.5) I.1-131: 1H-NMR (400.1 MHz, d6-DMSO): δ= 12.3518 (0.4); 12.3435 (0.4); 12.3082 (0.4); 12.2984 (0.3); 7.4050 (1.1); 7.3986 (11.0); 7.3938 (3.9); 7.3825 (4.3); 7.3775 (16.0); 7.3713 (2.1); 7.2635 (12.0); 7.2423 (9.1); 4.6561 (4.4); 4.6174 (5.0); 4.1363 (4.8); 4.0974 (4.3); 3.7350 (0.7); 3.7243 (1.4); 3.7134 (2.0); 3.7023 (2.1); 3.6927 (2.0); 3.6825 (1.6); 3.6723 (0.8); 3.3610 (29.7); 3.1686 (3.1); 2.6860 (3.4); 2.6761 (3.7); 2.6690 (1.5); 2.6643 (1.0); 2.6594 (0.6); 2.6463 (4.1); 2.6364 (4.0); 2.5487 (0.9); 2.5441 (1.2); 2.5394 (1.8); 2.5224 (2.7); 2.5091 (70.4); 2.5045 (154.6); 2.4999 (218.8); 2.4953 (158.4); 2.4907 (75.2); 2.4564 (1.0); 2.4517 (0.4); 2.4417 (0.4); 2.4243 (1.1); 2.4169 (1.1); 2.4000 (2.4); 2.3825 (1.9); 2.3764 (1.8); 2.3591 (1.7); 2.3358 (0.6); 2.3313 (1.2); 2.3258 (5.1); 2.3176 (0.9); 2.3030 (4.1); 2.2923 (2.0); 2.2861 (3.8); 2.2786 (2.2); 2.2678 (3.0); 2.2634 (3.9); 2.2540 (2.9); 2.2374 (0.8); 2.2262 (1.7); 2.2133 (1.8); 2.1972 (1.2); 2.1789 (1.5); 2.1730 (0.8); 2.1668 (1.4); 2.1614 (1.1); 2.1541 (1.1); 2.1487 (1.8); 2.1424 (1.2); 2.1369 (0.9); 2.1295 (1.2); 2.1233 (1.2); 2.1047 (0.7); 2.0709 (0.7); 1.7362 (0.9); 1.7240 (1.4); 1.7128 (1.8); 1.7015 (1.4); 1.6936 (1.6); 1.6883 (1.2); 1.6813 (1.7); 1.6702 (1.1); 1.6561 (0.7); 0.0082 (0.7); 0.0000 (23.2) I.1-132: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.6290 (3.4); 7.3855 (0.4); 7.3818 (0.5); 7.3649 (1.0); 7.3611 (1.1); 7.3553 (0.6); 7.3452 (0.7); 7.3391 (1.1); 7.3353 (1.0); 7.3189 (0.6); 7.3151 (0.5); 7.2120 (0.6); 7.2081 (0.6); 7.1992 (0.6); 7.1954 (0.8); 7.1920 (1.1); 7.1884 (1.2); 7.1792 (1.1); 7.1760 (1.2); 7.1720 (0.8); 7.1679 (0.8); 7.1589 (0.6); 7.1554 (0.7); 7.0760 (1.1); 7.0599 (1.6); 7.0569 (1.5); 7.0406 (0.8); 4.7255 (1.8); 4.6858 (2.1); 4.2447 (2.2); 4.2045 (1.9); 3.8415 (0.4); 3.8311 (0.7); 3.8205 (1.0); 3.8099 (1.1); 3.7996 (1.0); 3.7898 (0.8); 3.7800 (0.4); 3.5958 (0.7); 3.5787 (1.8); 3.5615 (2.6); 3.5443 (1.9); 3.5271 (0.7); 3.3514 (45.5); 3.1684 (5.7); 2.7907 (1.5); 2.7807 (1.5); 2.7524 (1.8); 2.7424 (1.8); 2.6742 (0.5); 2.6696 (0.7); 2.6650 (0.5); 2.5446 (0.4); 2.5400 (0.9); 2.5231 (1.6); 2.5184 (2.5); 2.5098 (38.6); 2.5052 (84.3); 2.5006 (118.7); 2.4960 (86.2); 2.4914 (41.1); 2.4656 (2.4); 2.4433 (2.0); 2.4272 (1.7); 2.4157 (0.7); 2.4051 (1.7); 2.3988 (1.4); 2.3796 (1.2); 2.3763 (1.1); 2.3578 (0.9); 2.3320 (0.5); 2.3274 (0.8); 2.3228 (0.6); 2.3040 (0.8); 2.2916 (1.0); 2.2798 (1.4); 2.2673 (1.4); 2.2380 (0.8); 2.2271 (1.0); 2.2219 (0.8); 2.2039 (0.9); 2.1978 (0.4); 2.1922 (0.7); 2.1850 (0.6); 2.1795 (0.6); 2.1730 (1.1); 2.1684 (0.6); 2.1608 (0.4); 2.1534 (0.6); 2.1488 (0.7); 2.0721 (0.7); 1.7729 (0.4); 1.7633 (0.8); 1.7520 (0.8); 1.7415 (0.9); 1.7332 (1.0); 1.7292 (0.6); 1.7213 (0.7); 1.7092 (0.6); 1.6974 (0.4); 1.2611 (15.5); 1.2593 (16.0); 1.2439 (15.5); 1.2422 (16.0); 0.0083 (0.5) I.1-133: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.5844 (6.7); 7.5807 (7.4); 7.5644 (8.5); 7.5607 (8.7); 7.3707 (8.1); 7.3511 (16.0); 7.3313 (9.2); 7.2291 (7.7); 7.2273 (7.2); 7.2256 (8.2); 7.2098 (6.2); 7.2062 (6.2); 4.7040 (7.5); 4.6628 (9.2); 4.3067 (8.8); 4.2654 (7.4); 3.8384 (1.3); 3.8279 (2.5); 3.8173 (3.6); 3.8074 (4.1); 3.7979 (3.6); 3.7874 (2.9); 3.7769 (1.3); 3.7634 (0.4); 3.7424 (0.4); 3.5954 (1.0); 3.5574 (0.8); 3.5198 (0.6); 2.6743 (5.6); 2.6637 (5.7); 2.6344 (7.3); 2.6237 (7.2); 2.5507 (0.3); 2.5460 (0.3); 2.5407 (0.4); 2.5238 (0.7); 2.5191 (1.1); 2.5105 (21.2); 2.5059 (47.2); 2.5013 (67.0); 2.4966 (48.9); 2.4921 (23.6); 2.4808 (2.8); 2.4628 (2.5); 2.4516 (1.0); 2.4492 (1.0); 2.4391 (5.0); 2.4324 (8.3); 2.4224 (3.8); 2.4161 (4.4); 2.4109 (8.2); 2.3925 (6.3); 2.3709 (5.8); 2.3322 (2.8); 2.3198 (2.7); 2.3078 (5.0); 2.2958 (5.1); 2.2740 (3.6); 2.2701 (5.7); 2.2636 (4.9); 2.2613 (4.7); 2.2579 (3.9); 2.2525 (2.6); 2.2470 (1.5); 2.2402 (3.6); 2.2334 (1.5); 2.2280 (1.2); 2.2212 (2.2); 2.2155 (1.9); 2.1969 (1.0); 2.0720 (14.2); 1.8181 (0.9); 1.8127 (0.6); 1.7960 (1.8); 1.7906 (2.2); 1.7841 (3.3); 1.7768 (2.3); 1.7735 (3.0); 1.7668 (2.0); 1.7613 (2.8); 1.7541 (2.1); 1.7424 (2.4); 1.7305 (1.3); 0.0000 (8.9) I.1-134: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1491 (1.0); 8.1259 (0.9); 8.0619 (1.0); 8.0387 (1.0); 7.2207 (2.8); 7.2080 (7.7); 7.1973 (1.0); 7.1550 (2.3); 7.1410 (3.2); 7.1365 (4.8); 4.7742 (1.6); 4.7675 (1.8); 4.7354 (1.8); 4.7284 (2.0); 4.3341 (1.0); 4.3225 (1.2); 4.3122 (1.2); 4.3007 (1.1); 4.1557 (0.8); 4.1407 (0.9); 4.1197 (0.7); 4.0955 (0.7); 4.0630 (2.0); 4.0249 (1.6); 3.6475 (1.1); 3.3868 (1.0); 3.3332 (112.0); 3.2832 (1.8); 3.1655 (2.6); 2.6744 (1.6); 2.6698 (2.5); 2.6652 (1.8); 2.6255 (1.9); 2.6091 (4.5); 2.5905 (5.3); 2.5715 (2.6); 2.5617 (2.4); 2.5567 (2.4); 2.5519 (1.7); 2.5233 (4.7); 2.5186 (7.5); 2.5099 (139.3); 2.5053 (308.9); 2.5007 (435.6); 2.4960 (304.6); 2.4915 (135.2); 2.4549 (4.4); 2.4504 (6.4); 2.4458 (5.2); 2.3856 (1.6); 2.3320 (2.1); 2.3275 (2.6); 2.3228 (2.2); 2.3120 (1.7); 2.2777 (2.2); 2.2539 (1.5); 2.2202 (0.8); 2.0730 (0.8); 2.0333 (0.9); 2.0050 (1.1); 1.9821 (1.0); 1.8305 (1.6); 1.2443 (0.9); 1.1439 (6.3); 1.1403 (4.4); 1.1253 (13.2); 1.1215 (8.8); 1.1063 (6.2); 1.1026 (4.3); 0.8546 (7.6); 0.8475 (11.5); 0.8375 (10.4); 0.8294 (16.0); 0.8106 (4.0); 0.0506 (1.1); 0.0079 (5.7); -0.0002 (207.1); -0.0085 (6.1); -0.0506 (2.2) I.1-135: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6528 (0.6); 8.6380 (1.2); 8.6238 (0.6); 8.5781 (1.1); 8.5760 (1.3); 8.5739 (1.3); 8.5718 (1.2); 8.5654 (1.2); 8.5634 (1.3); 8.5613 (1.3); 8.5591 (1.1); 7.9472 (0.5); 7.9318 (1.0); 7.9285 (1.0); 7.9123 (0.6); 7.9089 (0.6); 7.4323 (0.8); 7.4190 (0.9); 7.3988 (1.8); 7.3775 (1.6); 7.3603 (0.7); 7.3563 (0.8); 7.3501 (0.4); 7.3407 (0.5); 7.3344 (0.8); 7.3305 (0.7); 7.3142 (0.4); 7.3104 (0.4); 7.2071 (0.4); 7.2031 (0.5); 7.1942 (0.4); 7.1903 (0.6); 7.1873 (0.8); 7.1833 (0.9); 7.1745 (0.8); 7.1708 (0.9); 7.1668 (0.6); 7.1629 (0.6); 7.1541 (0.5); 7.1504 (0.5); 7.0785 (0.8); 7.0628 (1.1); 7.0593 (1.1); 7.0432 (0.6); 4.7472 (1.3); 4.7077 (1.5); 4.3997 (2.5); 4.3840 (2.4); 4.2485 (1.6); 4.2086 (1.4); 3.8481 (0.4); 3.8371 (0.6); 3.8266 (0.9); 3.8166 (1.1); 3.8067 (0.9); 3.7961 (0.7); 3.7848 (0.5); 3.7295 (0.4); 3.5405 (16.0); 3.1687 (4.8); 2.6757 (0.4); 2.6710 (0.5); 2.6664 (0.4); 2.6508 (1.1); 2.6396 (1.1); 2.6155 (1.4); 2.6042 (1.3); 2.5413 (0.4); 2.5244 (0.8); 2.5198 (1.2); 2.5111 (26.6); 2.5065 (60.5); 2.5019 (86.4); 2.4973 (61.2); 2.4926 (27.2); 2.4625 (0.4); 2.4577 (0.4); 2.4533 (0.4); 2.4114 (0.4); 2.3924 (0.5); 2.3886 (0.5); 2.3693 (1.0); 2.3449 (2.1); 2.3332 (0.6); 2.3282 (1.2); 2.3234 (1.9); 2.3094 (1.3); 2.2913 (0.9); 2.2878 (1.4); 2.2783 (0.9); 2.2674 (1.1); 2.2542 (1.1); 2.2498 (0.5); 2.2366 (0.4); 2.2255 (0.6); 2.2125 (0.6); 2.1656 (0.4); 2.1464 (0.7); 2.1419 (0.4); 2.1341 (0.5); 2.1270 (0.4); 2.1222 (0.6); 2.1148 (0.9); 2.1101 (0.5); 2.0954 (0.5); 2.0907 (0.6); 2.0735 (4.4); 1.8185 (0.4); 1.8059 (0.5); 1.7951 (0.7); 1.7847 (0.6); 1.7737 (0.6); 1.7634 (0.7); 1.7529 (0.4) I.1-136: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.4210 (6.6); 7.3999 (16.0); 7.3939 (12.1); 7.3788 (12.0); 7.3729 (15.2); 7.3517 (7.3); 7.3017 (5.6); 7.2966 (5.8); 7.2821 (5.9); 7.2767 (6.8); 7.2729 (6.5); 7.2675 (6.0); 7.2530 (5.6); 7.2479 (5.6); 7.1011 (5.8); 7.0947 (5.9); 7.0902 (6.2); 7.0849 (6.1); 7.0798 (5.4); 7.0738 (5.2); 7.0693 (5.1); 6.8936 (7.3); 4.6306 (12.5); 4.5918 (14.5); 4.1363 (15.9); 4.0974 (13.7); 3.7886 (2.3); 3.7773 (5.2); 3.7663 (6.5); 3.7571 (7.5); 3.7465 (6.8); 3.7355 (5.5); 3.7242 (2.6); 3.3864 (1.7); 3.3774 (0.8); 3.3371 (642.8); 3.2858 (0.5); 3.2699 (0.4); 3.1703 (0.7); 2.6803 (0.4); 2.6757 (0.9); 2.6711 (1.3); 2.6666 (1.0); 2.6619 (0.4); 2.5558 (0.3); 2.5513 (0.5); 2.5467 (0.5); 2.5415 (0.5); 2.5247 (3.1); 2.5199 (4.4); 2.5112 (76.3); 2.5067 (164.1); 2.5021 (231.1); 2.4976 (158.5); 2.4930 (75.4); 2.4664 (12.9); 2.4552 (12.2); 2.4024 (2.5); 2.3841 (3.3); 2.3791 (3.1); 2.3606 (8.3); 2.3421 (7.4); 2.3373 (7.2); 2.3291 (2.1); 2.3191 (7.0); 2.2992 (6.4); 2.2846 (7.7); 2.2752 (9.1); 2.2608 (9.4); 2.2429 (2.9); 2.2333 (4.4); 2.2191 (4.3); 2.1494 (3.2); 2.1300 (6.9); 2.1253 (14.6); 2.1178 (5.0); 2.1116 (4.4); 2.1027 (13.5); 2.0897 (11.6); 2.0800 (4.5); 2.0747 (5.5); 2.0717 (4.2); 2.0675 (9.9); 2.0562 (2.5); 1.7439 (3.0); 1.7301 (4.2); 1.7193 (5.0); 1.7118 (4.1); 1.7088 (4.7); 1.6980 (4.6); 1.6948 (3.8); 1.6870 (4.3); 1.6769 (3.4); 1.6627 (2.4) I.1-137: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.0177 (7.8); 9.0141 (8.9); 9.0070 (8.2); 9.0031 (8.7); 8.6645 (5.0); 8.6437 (5.5); 8.5983 (3.3); 8.5842 (6.2); 8.0113 (8.1); 7.9896 (10.5); 7.8133 (7.6); 7.7952 (9.4); 7.7741 (7.4); 7.6981 (5.9); 7.6869 (6.0); 7.6764 (5.6); 7.6656 (6.3); 7.5930 (9.0); 7.5756 (7.9); 7.3724 (2.3); 7.3522 (5.1); 7.3304 (4.8); 7.3059 (2.5); 7.1919 (2.8); 7.1723 (5.6); 7.1595 (5.2); 7.1428 (2.7); 7.0663 (4.3); 7.0513 (6.0); 7.0321 (3.8); 4.8225 (2.4); 4.8076 (2.5); 4.7849 (6.2); 4.7704 (6.5); 4.7398 (6.6); 4.7247 (8.7); 4.7017 (3.8); 4.6810 (7.9); 4.2205 (8.8); 4.1807 (7.9); 3.8393 (12.3); 3.8284 (14.2); 3.8170 (15.8); 3.8076 (16.0); 3.7981 (15.4); 3.2169 (2.0); 3.1660 (14.6); 2.7573 (2.0); 2.6750 (3.6); 2.6701 (5.2); 2.6655 (4.4); 2.6221 (5.0); 2.6112 (5.4); 2.5870 (6.2); 2.5760 (6.7); 2.5566 (2.5); 2.5237 (8.2); 2.5190 (14.1); 2.5103 (317.8); 2.5057 (712.5); 2.5011 (1013.9); 2.4965 (712.6); 2.4919 (319.1); 2.4557 (7.8); 2.4510 (10.0); 2.4464 (7.4); 2.4012 (2.7); 2.3753 (2.6); 2.3564 (3.2); 2.3325 (9.5); 2.3280 (7.1); 2.3232 (5.2); 2.3131 (5.7); 2.2975 (8.2); 2.2895 (5.6); 2.2755 (8.6); 2.2698 (5.8); 2.2624 (7.9); 2.2561 (6.1); 2.2455 (7.9); 2.2407 (7.7); 2.2324 (6.4); 2.2146 (3.2); 2.2038 (3.8); 2.1908 (3.9); 2.1485 (2.5); 2.1291 (3.9); 2.1050 (3.2); 2.0978 (4.9); 2.0734 (6.6); 2.0544 (1.7); 1.7691 (1.9); 1.7562 (3.2); 1.7457 (4.0); 1.7322 (3.6); 1.7138 (3.4); 1.7026 (2.6); 0.0505 (2.3); 0.0080 (18.1); 0.0063 (5.3); 0.0055 (5.9); 0.0047 (7.1); 0.0038 (9.5); -0.0002 (601.3); - 0.0027 (33.5); -0.0051 (8.4); -0.0060 (5.9); -0.0068 (5.3); -0.0085 (17.3); -0.0504 (4.4) I.1-139: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4300 (2.3); 7.4261 (2.5); 7.4103 (2.6); 7.4063 (2.6); 7.3109 (1.0); 7.3070 (1.1); 7.2901 (2.0); 7.2717 (1.6); 7.2677 (1.4); 7.1583 (2.5); 7.1551 (2.6); 7.1375 (2.0); 7.1342 (2.0); 7.1266 (2.0); 7.1059 (7.5); 7.0927 (8.0); 7.0721 (2.0); 6.9891 (1.5); 6.9857 (1.5); 6.9698 (2.2); 6.9667 (2.2); 6.9509 (1.2); 6.9475 (1.1); 4.6533 (2.0); 4.6148 (2.2); 4.3963 (0.8); 4.3654 (1.2); 4.3547 (3.2); 4.3445 (3.3); 4.3350 (1.6); 4.2451 (3.3); 4.2340 (4.5); 4.2227 (2.2); 4.0468 (2.3); 4.0084 (2.0); 3.7270 (0.7); 3.7164 (1.0); 3.7062 (1.1); 3.6960 (1.0); 3.6853 (0.7); 3.3456 (0.8); 3.3231 (348.6); 3.2993 (19.9); 3.2734 (1.4); 2.7850 (1.4); 2.7751 (1.4); 2.7455 (1.8); 2.7354 (1.7); 2.6704 (0.7); 2.5237 (1.7); 2.5102 (43.8); 2.5057 (93.7); 2.5012 (129.4); 2.4967 (92.7); 2.4923 (43.5); 2.4651 (2.1); 2.4429 (2.0); 2.4254 (1.9); 2.4035 (1.9); 2.3813 (1.2); 2.3636 (1.0); 2.3397 (0.9); 2.3326 (0.7); 2.3280 (0.8); 2.2609 (16.0); 2.2412 (1.4); 2.2275 (1.2); 2.1994 (0.8); 2.1859 (0.8); 2.1525 (0.5); 2.1335 (0.8); 2.1205 (0.6); 2.1143 (0.6); 2.1087 (0.6); 2.1023 (1.0); 2.0777 (0.6); 1.7226 (0.7); 1.7116 (0.8); 1.7016 (0.7); 1.6915 (0.7); 1.6799 (0.8); 1.6684 (0.5); -0.0002 (7.5) I.1-140: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1469 (1.2); 7.1265 (4.1); 7.1094 (4.4); 7.0890 (1.3); 4.6566 (1.2); 4.6183 (1.3); 4.1470 (1.3); 4.1310 (2.8); 4.1146 (1.5); 4.0634 (1.4); 4.0255 (1.3); 3.7225 (0.6); 3.7121 (0.7); 3.7018 (0.6); 3.3629 (60.9); 2.7634 (0.8); 2.7533 (0.8); 2.7238 (1.1); 2.7137 (1.0); 2.6616 (2.2); 2.6450 (4.4); 2.6284 (2.0); 2.5098 (16.5); 2.5056 (34.2); 2.5012 (46.7); 2.4968 (33.3); 2.4926 (15.6); 2.4501 (1.2); 2.4280 (1.3); 2.4104 (0.9); 2.4026 (0.7); 2.3882 (1.0); 2.3788 (0.6); 2.2905 (0.6); 2.2762 (9.8); 2.2664 (1.0); 2.2524 (0.7); 2.1279 (0.5); 2.0600 (16.0); 1.7180 (0.5) I.1-142: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1471 (2.0); 7.1270 (5.9); 7.1079 (6.5); 7.0874 (2.0); 4.6492 (1.8); 4.6111 (2.0); 4.0552 (2.0); 4.0382 (1.5); 4.0203 (5.5); 4.0029 (5.1); 3.9851 (1.7); 3.7231 (0.7); 3.7126 (1.0); 3.7022 (1.1); 3.6920 (1.0); 3.6815 (0.7); 3.4004 (1.7); 3.3681 (218.9); 3.1673 (0.6); 2.7323 (1.4); 2.7221 (1.4); 2.6927 (1.8); 2.6824 (1.8); 2.6759 (0.6); 2.6714 (0.8); 2.6667 (0.6); 2.5416 (0.7); 2.5248 (2.2); 2.5201 (3.2); 2.5114 (48.6); 2.5069 (103.0); 2.5023 (138.9); 2.4977 (96.6); 2.4931 (43.3); 2.4272 (2.0); 2.4199 (0.5); 2.4121 (0.5); 2.4053 (2.0); 2.3952 (1.2); 2.3876 (1.6); 2.3766 (0.8); 2.3710 (0.8); 2.3657 (1.6); 2.3532 (0.8); 2.3336 (0.6); 2.3291 (0.8); 2.3244 (0.6); 2.2887 (1.0); 2.2761 (14.5); 2.2643 (1.5); 2.2504 (1.2); 2.2224 (0.7); 2.2090 (0.8); 2.1501 (0.7); 2.1371 (0.6); 2.1313 (0.5); 2.1247 (0.5); 2.1185 (0.8); 2.1126 (0.5); 2.0993 (0.5); 2.0934 (0.5); 2.0752 (0.6); 1.7062 (0.6); 1.6952 (0.8); 1.6843 (0.6); 1.6745 (0.6); 1.6632 (0.7); 1.1521 (7.4); 1.1343 (16.0); 1.1165 (7.2); -0.0002 (8.8) I.1-143: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9947 (5.4); 7.9910 (5.3); 7.9734 (5.5); 7.9223 (2.0); 7.9024 (1.8); 7.7391 (2.6); 7.7241 (5.3); 7.7203 (5.7); 7.7078 (16.0); 7.7041 (13.2); 7.6893 (2.8); 7.6077 (3.8); 7.6024 (3.7); 7.5912 (3.7); 7.5880 (4.5); 7.5819 (3.7); 7.5722 (3.0); 7.5664 (2.4); 7.1599 (8.3); 7.1402 (11.6); 7.0972 (2.2); 7.0588 (12.5); 7.0388 (8.4); 4.5621 (4.4); 4.5244 (5.0); 4.2770 (5.7); 4.2642 (8.9); 4.2494 (6.7); 4.1467 (2.3); 3.9598 (5.2); 3.9205 (4.7); 3.8923 (6.1); 3.8768 (7.6); 3.8646 (4.6); 3.4881 (3.7); 3.4761 (5.0); 3.4642 (4.4); 3.4459 (3.7); 3.4324 (3.6); 3.3759 (2.2); 3.3502 (7.2); 3.3230 (3678.0); 3.2991 (180.8); 3.1748 (3.0); 3.1617 (2.9); 2.6749 (4.5); 2.6703 (6.3); 2.6658 (4.6); 2.5404 (3.8); 2.5236 (17.3); 2.5103 (395.8); 2.5057 (840.7); 2.5012 (1154.2); 2.4966 (811.6); 2.4922 (370.4); 2.3538 (4.1); 2.3432 (5.1); 2.3281 (8.0); 2.3234 (7.7); 2.3136 (4.9); 2.3031 (6.7); 2.2918 (34.9); 2.2653 (4.5); 2.2560 (2.6); 2.2406 (3.0); 2.2310 (3.2); 2.2168 (3.3); 2.1888 (1.9); 2.0729 (3.6); 2.0529 (2.2); 2.0205 (2.3); 1.9737 (4.2); 1.9517 (3.8); 1.9338 (3.4); 1.9117 (3.7); 1.5148 (1.8); -0.0002 (34.6) I.1-144: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.4881 (1.2); 8.1118 (0.9); 8.1095 (1.0); 8.0910 (1.0); 8.0887 (1.0); 7.8875 (1.0); 7.8838 (1.1); 7.8676 (1.1); 7.8640 (1.1); 7.6073 (0.6); 7.6032 (0.6); 7.5888 (0.7); 7.5852 (0.8); 7.5825 (0.6); 7.5681 (0.6); 7.5640 (0.6); 7.2204 (0.8); 7.2174 (0.8); 7.2019 (1.0); 7.2006 (1.0); 7.1991 (1.0); 7.1977 (1.0); 7.1823 (0.8); 7.1793 (0.8); 7.0880 (0.6); 4.7547 (0.7); 4.7150 (0.8); 4.3180 (0.9); 4.2781 (0.8); 3.9160 (0.5); 3.8292 (16.0); 3.3433 (14.2); 2.8442 (0.6); 2.8322 (0.6); 2.8069 (0.8); 2.7949 (0.7); 2.5970 (0.8); 2.5768 (0.7); 2.5596 (0.5); 2.5395 (0.7); 2.5240 (0.6); 2.5193 (0.8); 2.5106 (10.6); 2.5060 (22.8); 2.5014 (31.7); 2.4968 (22.1); 2.4922 (9.7); 2.4418 (0.7); 2.2978 (0.6); 2.2851 (0.6); 2.2484 (0.6); -0.0002 (2.8) I.1-145: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0020 (8.6); 7.9840 (6.4); 7.9805 (16.0); 7.7422 (5.7); 7.7370 (5.2); 7.7209 (4.6); 7.7157 (4.9); 7.1689 (5.4); 7.1495 (8.4); 7.0802 (9.1); 7.0603 (6.0); 4.6046 (3.1); 4.5662 (3.5); 4.2941 (4.0); 4.2801 (6.9); 4.2665 (4.6); 3.9841 (3.6); 3.9457 (3.2); 3.9084 (3.6); 3.8978 (4.5); 3.8929 (5.2); 3.8845 (2.5); 3.5524 (1.8); 3.5418 (1.8); 3.3331 (327.8); 3.1846 (2.2); 2.6856 (1.6); 2.5808 (1.5); 2.5390 (3.6); 2.5256 (88.4); 2.5211 (193.0); 2.5164 (270.1); 2.5118 (187.0); 2.5072 (84.0); 2.4548 (2.4); 2.4435 (2.6); 2.4138 (2.7); 2.4037 (3.1); 2.3574 (2.2); 2.3389 (2.8); 2.3014 (24.0); 2.2819 (2.2); 2.2672 (1.9); 2.2569 (2.3); 2.2425 (2.1); 2.0661 (2.9); 2.0457 (3.0); 2.0273 (3.0); 2.0062 (2.0); 1.5494 (1.5); 0.0156 (2.3) I.1-146: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5215 (0.9); 7.3826 (14.6); 7.3724 (0.5); 7.3621 (16.5); 7.2626 (183.5); 7.2570 (12.6); 7.1286 (1.1); 7.1191 (1.6); 7.1130 (1.6); 7.1039 (3.7); 7.0913 (2.6); 7.0888 (2.5); 7.0852 (2.9); 7.0772 (3.8); 7.0703 (1.8); 7.0651 (2.0); 7.0609 (4.2); 7.0573 (7.8); 7.0498 (11.2); 7.0472 (6.9); 7.0411 (10.1); 7.0338 (4.0); 7.0306 (6.0); 7.0272 (7.6); 7.0219 (7.4); 7.0127 (1.0); 7.0067 (6.4); 7.0015 (6.1); 5.4813 (2.4); 5.2999 (8.8); 4.8500 (4.8); 4.8464 (4.7); 4.8114 (5.4); 4.8076 (5.2); 4.2343 (7.0); 4.1957 (6.2); 3.9418 (1.1); 3.9306 (2.3); 3.9198 (2.9); 3.9095 (3.3); 3.8996 (2.9); 3.8888 (2.4); 3.8779 (1.1); 3.5433 (0.6); 3.5256 (1.3); 3.5092 (2.9); 3.4914 (5.9); 3.4761 (6.0); 3.4736 (6.2); 3.4715 (5.8); 3.4563 (5.8); 3.4390 (3.0); 3.4219 (1.3); 3.4049 (0.6); 2.7820 (8.4); 2.7644 (16.0); 2.7470 (7.1); 2.5969 (5.0); 2.5860 (5.0); 2.5607 (5.7); 2.5498 (5.6); 2.5240 (1.0); 2.5039 (1.3); 2.5005 (1.2); 2.4805 (3.6); 2.4609 (3.3); 2.4574 (3.1); 2.4380 (3.1); 2.4276 (3.6); 2.4129 (4.2); 2.4035 (5.0); 2.3890 (5.0); 2.3847 (1.8); 2.3701 (1.4); 2.3605 (2.3); 2.3462 (2.2); 2.2757 (2.0); 2.2565 (3.1); 2.2518 (1.9); 2.2430 (2.4); 2.2375 (2.0); 2.2325 (2.6); 2.2240 (3.3); 2.2190 (2.2); 2.2136 (1.5); 2.2048 (2.1); 2.1997 (2.6); 2.1808 (1.4); 2.1412 (6.3); 2.1189 (6.2); 2.1050 (5.4); 2.0827 (5.3); 1.8164 (1.6); 1.8051 (1.8); 1.8023 (2.0); 1.7913 (2.3); 1.7818 (2.2); 1.7785 (1.9); 1.7724 (1.8); 1.7692 (2.2); 1.7580 (2.0); 1.7488 (1.5); 1.7457 (1.4); 1.7342 (1.2); 0.0080 (1.5); -0.0002 (51.8); -0.0085 (1.4) I.1-147: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1493 (1.8); 7.1289 (7.4); 7.1156 (8.2); 7.0949 (1.9); 4.6625 (5.2); 4.6584 (7.2); 4.6566 (7.6); 4.6527 (5.5); 4.6189 (2.4); 4.0542 (2.3); 4.0160 (2.0); 3.7227 (0.7); 3.7121 (1.0); 3.7017 (1.2); 3.6913 (1.0); 3.6808 (0.8); 3.5666 (2.3); 3.5605 (5.0); 3.5544 (2.3); 3.3988 (0.8); 3.3677 (137.6); 2.8045 (1.5); 2.7943 (1.5); 2.7645 (1.9); 2.7543 (1.9); 2.6716 (0.5); 2.5249 (1.0); 2.5202 (1.6); 2.5116 (30.6); 2.5071 (65.4); 2.5025 (89.4); 2.4980 (63.0); 2.4934 (29.0); 2.4784 (2.6); 2.4695 (0.6); 2.4603 (2.0); 2.4384 (2.2); 2.4154 (1.2); 2.3971 (1.0); 2.3919 (0.9); 2.3735 (0.8); 2.3293 (0.6); 2.2868 (1.2); 2.2779 (16.0); 2.2625 (1.4); 2.2493 (1.4); 2.2325 (0.5); 2.2208 (0.8); 2.2079 (0.9); 2.1667 (0.6); 2.1478 (0.8); 2.1350 (0.7); 2.1288 (0.6); 2.1227 (0.6); 2.1165 (1.0); 2.1108 (0.6); 2.0969 (0.6); 2.0914 (0.7); 2.0721 (0.5); 1.7081 (0.7); 1.6967 (0.9); 1.6857 (0.8); 1.6764 (0.8); 1.6648 (0.8); 1.6536 (0.5); -0.0002 (3.3) I.1-148: 1H-NMR (400.1 MHz, d6-DMSO): δ= 12.5995 (0.3); 12.5697 (0.4); 12.5511 (0.5); 12.5463 (0.4); 12.5223 (0.5); 12.4648 (0.4); 12.4379 (0.4); 7.3853 (1.4); 7.3652 (3.4); 7.3414 (3.4); 7.3197 (1.9); 7.2747 (0.7); 7.2564 (0.8); 7.2304 (1.0); 7.2122 (2.2); 7.1924 (3.7); 7.1797 (4.0); 7.1592 (2.1); 7.0754 (3.3); 7.0579 (5.0); 7.0392 (2.5); 4.7722 (3.3); 4.7485 (10.2); 4.7243 (16.0); 4.7001 (4.0); 4.6850 (6.7); 4.2406 (6.5); 4.2007 (5.7); 3.8510 (1.0); 3.8408 (2.0); 3.8308 (2.8); 3.8203 (3.4); 3.8107 (2.9); 3.7991 (2.2); 3.7910 (1.1); 3.5879 (0.4); 3.5774 (0.3); 3.5542 (0.6); 3.5450 (0.4); 3.3775 (42.3); 3.3101 (2.3); 3.2937 (1.6); 3.2848 (1.2); 3.2669 (1.0); 3.2543 (0.8); 3.2122 (0.5); 3.1963 (0.4); 3.1810 (0.4); 3.1719 (6.6); 3.1700 (6.3); 3.1686 (7.7); 2.8345 (0.5); 2.8151 (1.0); 2.8059 (3.6); 2.7964 (4.0); 2.7670 (4.4); 2.7575 (4.2); 2.6696 (1.4); 2.5478 (1.2); 2.5400 (0.7); 2.5040 (226.0); 2.5006 (244.5); 2.4646 (5.8); 2.4479 (5.0); 2.4250 (5.2); 2.4019 (3.8); 2.3827 (3.7); 2.3620 (2.5); 2.3271 (1.7); 2.3079 (2.2); 2.2959 (2.4); 2.2843 (3.2); 2.2715 (3.5); 2.2556 (0.8); 2.2421 (2.2); 2.2305 (3.1); 2.2099 (2.5); 2.1972 (2.0); 2.1779 (2.8); 2.1658 (1.2); 2.1571 (2.0); 2.1347 (0.8); 2.0751 (1.1); 2.0718 (1.2); 1.7679 (1.2); 1.7588 (2.3); 1.7472 (2.3); 1.7371 (2.7); 1.7282 (2.6); 1.7162 (2.1); 1.7045 (1.7); 1.6931 (1.0); 1.3458 (0.3); 1.3280 (0.6); 1.3112 (0.4); 1.2354 (0.3); 0.0082 (1.1); 0.0033 (24.6); 0.0013 (23.4) I.1-149: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4636 (0.7); 8.4502 (1.2); 8.4356 (0.6); 7.3295 (1.5); 7.3140 (2.3); 7.3103 (3.7); 7.2986 (1.2); 7.2932 (3.6); 7.2466 (1.7); 7.2332 (6.2); 7.2133 (4.0); 7.1397 (2.1); 7.1196 (7.0); 7.1023 (7.7); 7.0817 (2.3); 4.6713 (2.0); 4.6331 (2.2); 4.2544 (2.2); 4.2455 (2.5); 4.2400 (2.5); 4.2311 (2.3); 4.0080 (2.3); 3.9700 (2.0); 3.7475 (0.7); 3.7366 (1.0); 3.7260 (1.0); 3.7162 (1.0); 3.7055 (0.7); 3.3162 (153.6); 3.2651 (0.6); 3.1682 (0.6); 2.6741 (0.5); 2.6695 (0.7); 2.6646 (0.5); 2.5909 (1.3); 2.5799 (1.3); 2.5561 (1.6); 2.5451 (1.5); 2.5228 (1.8); 2.5180 (2.6); 2.5094 (45.4); 2.5049 (98.1); 2.5003 (136.7); 2.4957 (96.1); 2.4912 (43.6); 2.3661 (0.6); 2.3467 (1.2); 2.3272 (1.8); 2.3049 (1.0); 2.2744 (16.0); 2.2577 (1.2); 2.2475 (1.3); 2.2337 (1.3); 2.2158 (0.7); 2.2098 (1.8); 2.1873 (1.7); 2.1750 (1.5); 2.1524 (1.4); 2.0640 (0.8); 2.0519 (0.6); 2.0404 (0.7); 2.0328 (0.9); 2.0085 (0.8); 1.7348 (0.6); 1.7242 (0.9); 1.7134 (0.7); 1.7020 (0.7); 1.6923 (0.7); -0.0002 (0.5) I.1-150: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.4828 (0.9); 7.1786 (0.3); 7.0645 (0.4); 4.7372 (0.5); 4.6976 (0.6); 4.2484 (0.6); 4.2087 (0.5); 3.4007 (1.3); 2.7735 (16.0); 2.7376 (0.4); 2.7275 (0.4); 2.6998 (0.5); 2.6897 (0.5); 2.5098 (2.3); 2.5053 (5.1); 2.5007 (7.2); 2.4961 (5.3); 2.4916 (2.5); 2.4232 (0.5); 2.4012 (0.5); 2.3973 (0.4); 2.3857 (0.4); 2.3769 (0.3); 2.3637 (0.4); 2.2811 (0.4); 2.2687 (0.4) I.1-151: 1H-NMR (400.1 MHz, CDCl3): δ= 7.2638 (13.5); 7.0981 (0.6); 7.0862 (0.4); 7.0826 (0.4); 7.0795 (0.5); 7.0757 (0.6); 7.0731 (0.6); 7.0631 (0.4); 7.0566 (1.8); 7.0497 (1.8); 7.0462 (1.2); 7.0411 (1.9); 7.0329 (0.7); 7.0303 (0.7); 6.1081 (0.4); 4.8632 (0.9); 4.8597 (0.9); 4.8244 (1.0); 4.8208 (1.0); 4.2666 (1.3); 4.2278 (1.1); 3.9706 (0.4); 3.9601 (0.5); 3.9499 (0.7); 3.9398 (0.5); 3.9292 (0.4); 3.7080 (16.0); 3.5190 (0.5); 3.5143 (0.5); 3.5102 (0.3); 3.5019 (1.2); 3.4994 (1.1); 3.4947 (0.5); 3.4892 (1.2); 3.4862 (1.3); 3.4782 (0.3); 3.4741 (0.5); 3.4697 (0.5); 2.6137 (0.9); 2.6027 (0.9); 2.5775 (1.1); 2.5664 (1.1); 2.5387 (2.0); 2.5306 (0.8); 2.5240 (2.2); 2.5179 (0.5); 2.5091 (2.4); 2.4888 (0.6); 2.4845 (0.5); 2.4657 (0.6); 2.4400 (0.6); 2.4254 (0.7); 2.4157 (0.8); 2.4013 (0.9); 2.3972 (0.4); 2.3728 (0.4); 2.3586 (0.5); 2.3027 (0.4); 2.2838 (0.7); 2.2787 (0.5); 2.2703 (0.6); 2.2650 (0.6); 2.2595 (0.6); 2.2513 (0.8); 2.2461 (0.6); 2.2409 (0.4); 2.2323 (0.5); 2.2269 (0.6); 2.2081 (0.3); 2.1913 (1.2); 2.1695 (1.1); 2.1551 (1.0); 2.1332 (1.0); 1.8559 (0.3); 1.8536 (0.4); 1.8427 (0.4); 1.8326 (0.4); 1.8297 (0.4); 1.8234 (0.3); 1.8207 (0.4); 1.8184 (0.3); 1.8097 (0.4) I.1-152: 1H-NMR (400.1 MHz, CDCl3): δ= 7.3818 (1.8); 7.3778 (2.9); 7.3735 (0.8); 7.3587 (4.4); 7.3528 (0.6); 7.3104 (2.3); 7.3056 (0.7); 7.2922 (4.4); 7.2721 (2.5); 7.2594 (42.6); 7.2336 (1.6); 7.2203 (0.6); 7.2153 (2.2); 7.2103 (0.4); 7.1967 (0.6); 7.1313 (1.0); 7.1101 (8.8); 7.1047 (9.6); 7.0894 (0.6); 7.0836 (1.1); 4.8593 (2.1); 4.8215 (2.3); 4.2300 (3.0); 4.2131 (6.4); 4.1961 (3.3); 4.0170 (2.2); 3.9791 (2.0); 3.8450 (0.4); 3.8342 (0.7); 3.8238 (1.0); 3.8131 (1.2); 3.8027 (1.0); 3.7922 (0.8); 3.7818 (0.4); 3.1055 (3.4); 3.0885 (6.6); 3.0716 (3.2); 2.6202 (1.4); 2.6099 (1.4); 2.5814 (1.8); 2.5712 (1.8); 2.5398 (0.3); 2.5212 (0.4); 2.5158 (0.4); 2.4970 (1.1); 2.4784 (1.0); 2.4733 (0.9); 2.4546 (0.9); 2.4314 (0.9); 2.4171 (1.0); 2.4070 (1.2); 2.3927 (1.2); 2.3747 (0.4); 2.3642 (0.6); 2.3500 (0.6); 2.3250 (16.0); 2.3149 (2.1); 2.2927 (1.8); 2.2761 (1.4); 2.2540 (1.4); 2.2483 (0.5); 2.2288 (0.8); 2.2242 (0.4); 2.2154 (0.5); 2.2096 (0.5); 2.2045 (0.6); 2.1962 (0.9); 2.1914 (0.5); 2.1854 (0.3); 2.1770 (0.5); 2.1717 (0.7); 2.1526 (0.3); 1.8112 (0.4); 1.7981 (0.6); 1.7865 (0.8); 1.7768 (0.7); 1.7632 (0.6); 1.7538 (0.7); 1.7423 (0.4); 1.7290 (0.3); 1.5523 (12.1); 0.0080 (0.5); 0.0006 (15.6); 0.0000 (15.6) I.1-153: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2618 (32.7); 7.1138 (28.9); 6.7447 (3.0); 6.7251 (3.8); 6.6371 (2.7); 6.6333 (3.1); 6.5946 (1.9); 6.5903 (1.6); 6.5749 (1.5); 6.5706 (1.3); 5.9355 (2.7); 5.9320 (8.8); 5.9298 (9.0); 5.9262 (2.7); 5.3317 (0.6); 5.2982 (3.2); 4.7148 (1.8); 4.6773 (2.0); 4.1062 (1.8); 4.0686 (1.6); 3.9451 (0.6); 3.9348 (0.7); 3.9246 (1.1); 3.9143 (0.7); 3.9040 (0.6); 3.4499 (0.7); 3.4324 (1.2); 3.4174 (1.2); 3.4029 (1.2); 3.3883 (1.2); 3.3711 (0.7); 2.6922 (2.0); 2.6749 (4.1); 2.6576 (1.8); 2.4941 (1.4); 2.4827 (1.2); 2.4683 (0.9); 2.4582 (1.4); 2.4466 (2.1); 2.4260 (0.7); 2.4149 (0.8); 2.4006 (1.0); 2.3907 (1.1); 2.3766 (1.1); 2.3480 (0.6); 2.3338 (0.7); 2.3228 (16.0); 2.2088 (0.7); 2.1956 (0.5); 2.1847 (0.7); 2.1763 (0.8); 2.1715 (0.5); 2.1569 (0.5); 2.1520 (0.7); 2.0677 (1.5); 2.0464 (1.5); 2.0317 (1.3); 2.0104 (1.3); 1.7419 (0.6); 1.7320 (0.6); 1.7192 (0.6); 1.7087 (0.5); -0.0002 (9.8) I.1-154: 1H-NMR (400.1 MHz, d6-DMSO): δ= 12.3544 (0.4); 12.3433 (0.5); 12.3055 (0.6); 12.2962 (0.7); 12.2442 (0.9); 12.2247 (0.9); 12.2081 (0.8); 12.1752 (0.7); 12.1614 (0.5); 12.1562 (0.5); 12.1320 (0.4); 12.1302 (0.4); 12.1145 (0.4); 6.8506 (0.7); 6.8417 (0.7); 6.8341 (3.0); 6.8258 (0.7); 6.8173 (0.9); 6.8114 (0.8); 6.8023 (0.7); 6.7951 (2.7); 6.7786 (0.8); 5.7931 (4.3); 5.7540 (4.1); 5.6421 (0.4); 5.6308 (0.7); 5.6202 (0.3); 5.5905 (0.8); 5.5851 (0.8); 5.5812 (1.3); 5.5770 (0.8); 5.5716 (0.9); 5.5676 (0.5); 4.8167 (1.1); 4.8029 (1.4); 4.7982 (3.0); 4.7845 (3.2); 4.7803 (3.2); 4.7667 (3.1); 4.7620 (1.6); 4.7481 (1.2); 3.5778 (1.6); 3.4591 (0.3); 3.4076 (1.8); 3.3979 (0.7); 3.3589 (1.9); 3.3063 (431.0); 3.2145 (0.8); 3.2110 (0.8); 3.1747 (0.6); 3.1631 (0.7); 3.0280 (1.6); 3.0152 (1.6); 3.0018 (3.3); 2.9976 (2.1); 2.9924 (2.2); 2.9882 (3.3); 2.7250 (1.0); 2.7135 (2.1); 2.6998 (2.4); 2.6727 (9.1); 2.6693 (3.7); 2.6644 (2.4); 2.6590 (8.2); 2.6466 (8.4); 2.6279 (7.9); 2.6056 (2.4); 2.5870 (2.5); 2.5793 (1.0); 2.5564 (2.5); 2.5510 (0.9); 2.5461 (0.5); 2.5355 (4.2); 2.5226 (4.2); 2.5177 (6.5); 2.5092 (141.5); 2.5046 (308.9); 2.5001 (435.5); 2.4955 (310.0); 2.4909 (145.8); 2.4756 (7.2); 2.4678 (2.0); 2.4547 (1.3); 2.4493 (0.8); 2.4444 (1.5); 2.4319 (1.2); 2.3913 (13.1); 2.3849 (16.0); 2.3511 (1.7); 2.3386 (1.7); 2.3318 (2.5); 2.3272 (3.7); 2.3215 (3.4); 2.3106 (1.5); 2.3072 (2.0); 2.3023 (2.0); 2.2972 (2.1); 2.2897 (2.0); 2.2840 (1.4); 2.2795 (1.5); 2.2667 (1.3); 2.0846 (0.3); 2.0710 (1.5); 1.9211 (1.4); 1.9021 (1.6); 1.8980 (2.9); 1.8897 (1.3); 1.8791 (2.8); 1.8751 (1.5); 1.8709 (1.5); 1.8666 (2.3); 1.8562 (1.2); 1.8477 (2.4); 1.8437 (1.2); 1.8248 (1.1); 1.5443 (0.6); 0.0119 (0.6); 0.0082 (2.1) I.1-155: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2423 (0.5); 8.2285 (1.0); 8.2147 (0.5); 7.5641 (4.0); 7.3560 (0.8); 7.3402 (0.5); 7.3342 (0.8); 7.2872 (4.2); 7.2857 (4.3); 7.1856 (0.8); 7.1818 (0.8); 7.1727 (0.8); 7.1693 (0.8); 7.1654 (0.5); 7.0713 (0.8); 7.0553 (1.0); 7.0357 (0.5); 4.7306 (1.2); 4.6903 (1.4); 4.2163 (1.5); 4.1770 (1.3); 4.0842 (1.9); 4.0659 (7.0); 4.0568 (2.2); 4.0479 (7.0); 4.0437 (2.2); 4.0297 (1.9); 3.8004 (0.7); 3.7902 (0.9); 3.7804 (0.8); 3.7697 (0.5); 3.4701 (11.9); 3.1681 (0.6); 2.5323 (1.1); 2.5207 (1.6); 2.5104 (17.6); 2.5059 (39.0); 2.5012 (54.9); 2.4966 (39.0); 2.4920 (17.1); 2.3446 (0.9); 2.3235 (1.0); 2.3028 (0.7); 2.2754 (0.7); 2.2623 (0.8); 2.2514 (1.0); 2.2384 (1.0); 2.2176 (1.4); 2.2096 (0.6); 2.1961 (1.7); 2.1827 (1.1); 2.1611 (1.1); 2.1234 (0.6); 2.0995 (0.6); 2.0919 (0.8); 2.0732 (0.5); 2.0679 (0.6); 1.7485 (0.6); 1.7384 (0.6); 1.7274 (0.6); 1.7169 (0.6); 1.3358 (7.1); 1.3177 (16.0); 1.2995 (7.0); -0.0002 (2.5) I.1-156: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1470 (2.1); 7.1269 (6.1); 7.1058 (6.7); 7.0854 (2.3); 5.7717 (0.9); 5.7628 (0.5); 5.7458 (1.4); 5.7288 (1.5); 5.7197 (0.6); 5.7119 (0.5); 5.7030 (1.1); 5.6863 (0.5); 5.1026 (0.6); 5.0986 (1.6); 5.0941 (1.8); 5.0901 (0.8); 5.0595 (0.6); 5.0554 (1.5); 5.0510 (2.4); 5.0483 (2.2); 5.0437 (1.5); 5.0256 (0.7); 5.0227 (1.6); 5.0202 (1.2); 5.0180 (1.3); 5.0150 (0.6); 4.6553 (1.8); 4.6171 (2.1); 4.0484 (2.3); 4.0433 (3.2); 4.0266 (6.2); 4.0102 (5.0); 3.7143 (0.7); 3.7038 (1.0); 3.6934 (1.1); 3.6831 (1.0); 3.6727 (0.8); 3.4887 (14.9); 2.7377 (1.4); 2.7276 (1.4); 2.6982 (1.8); 2.6881 (1.7); 2.5203 (0.6); 2.5116 (11.0); 2.5072 (23.2); 2.5026 (31.5); 2.4981 (22.2); 2.4936 (10.2); 2.4285 (2.0); 2.4163 (0.6); 2.4067 (1.9); 2.3893 (1.9); 2.3743 (0.9); 2.3673 (2.1); 2.3509 (0.8); 2.3079 (0.7); 2.3047 (1.1); 2.3014 (0.7); 2.2913 (2.0); 2.2879 (3.7); 2.2849 (2.9); 2.2759 (16.0); 2.2617 (1.6); 2.2549 (1.3); 2.2510 (1.0); 2.2478 (1.4); 2.2308 (0.6); 2.2197 (0.8); 2.2063 (0.8); 2.1414 (0.7); 2.1288 (0.6); 2.1229 (0.5); 2.1166 (0.6); 2.1103 (0.8); 2.1044 (0.5); 2.0909 (0.5); 2.0852 (0.6); 1.7031 (0.6); 1.6917 (0.8); 1.6807 (0.7); 1.6712 (0.7); 1.6674 (0.5); 1.6598 (0.8); -0.0002 (2.7) I.1-157: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.0051 (2.4); 8.6554 (0.8); 8.6356 (0.8); 7.4178 (2.3); 7.1407 (1.9); 7.1208 (4.2); 7.0920 (4.5); 7.0717 (1.9); 4.6444 (1.2); 4.6060 (1.7); 4.5919 (0.6); 4.5822 (0.5); 3.9486 (1.3); 3.9107 (1.2); 3.6437 (0.7); 3.6273 (16.0); 3.6125 (0.6); 3.4337 (16.8); 3.1854 (0.5); 3.1677 (2.3); 3.1520 (0.6); 3.1280 (1.0); 3.1148 (0.9); 3.0484 (0.9); 3.0244 (0.9); 3.0107 (0.6); 2.9871 (0.6); 2.6697 (0.5); 2.5185 (2.2); 2.5098 (30.0); 2.5053 (63.5); 2.5006 (88.5); 2.4960 (61.1); 2.4914 (27.4); 2.4766 (1.2); 2.3368 (0.5); 2.3274 (0.6); 2.3180 (0.9); 2.2959 (0.8); 2.2752 (11.0); 2.2456 (0.6); 2.2325 (0.6); 2.2217 (0.8); 2.2071 (1.3); 2.1838 (1.0); 2.1719 (0.8); 2.1666 (0.6); 2.1494 (0.7); 1.9521 (0.6); 0.0080 (0.6); -0.0002 (19.6); -0.0086 (0.6) I.1-158: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2324 (0.9); 7.2136 (2.2); 7.1949 (1.4); 7.0826 (1.2); 7.0636 (0.9); 7.0296 (2.0); 7.0167 (1.2); 6.9969 (1.0); 4.6859 (1.3); 4.6476 (1.5); 4.0476 (1.5); 4.0093 (1.4); 3.9639 (0.8); 3.7124 (0.6); 3.7022 (0.8); 3.6927 (0.8); 3.6894 (0.8); 3.6798 (0.8); 3.6698 (0.7); 3.5535 (0.6); 3.1693 (16.0); 2.6925 (1.1); 2.6829 (1.1); 2.6529 (1.3); 2.6433 (1.3); 2.5107 (3.4); 2.5061 (7.3); 2.5015 (10.1); 2.4969 (7.0); 2.4923 (3.1); 2.4031 (0.8); 2.3848 (0.6); 2.3798 (0.6); 2.3616 (0.6); 2.3214 (1.5); 2.2981 (2.1); 2.2857 (11.3); 2.2733 (1.1); 2.2589 (1.9); 2.2315 (0.6); 2.2183 (0.6); 2.1654 (0.5); 2.1344 (0.6); 1.7095 (0.6); 1.6777 (0.6); - 0.0002 (2.4) I.1-159: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.4065 (2.2); 7.3908 (3.0); 7.3865 (4.4); 7.3713 (4.6); 7.3672 (3.6); 7.3515 (3.1); 7.2071 (4.4); 7.1160 (2.1); 7.1099 (2.5); 7.0934 (3.8); 7.0883 (4.5); 7.0755 (16.0); 7.0681 (3.1); 7.0571 (9.2); 7.0314 (3.3); 7.0273 (3.8); 6.9439 (4.6); 4.6331 (5.9); 4.5938 (6.9); 4.1675 (6.9); 4.1283 (5.9); 3.8352 (0.9); 3.8247 (2.0); 3.8141 (2.8); 3.8038 (3.2); 3.7935 (2.9); 3.7831 (2.2); 3.7726 (1.1); 2.8262 (3.7); 2.8159 (3.8); 2.7867 (4.6); 2.7764 (4.6); 2.6698 (0.3); 2.5232 (0.4); 2.5185 (0.7); 2.5098 (18.0); 2.5053 (40.8); 2.5007 (58.1); 2.4961 (43.1); 2.4917 (21.1); 2.4749 (5.0); 2.4526 (4.9); 2.4353 (4.1); 2.4248 (1.8); 2.4131 (4.0); 2.4067 (3.8); 2.3880 (2.9); 2.3836 (2.8); 2.3650 (2.5); 2.3322 (0.3); 2.3276 (0.5); 2.3189 (2.3); 2.3055 (2.6); 2.2946 (3.5); 2.2813 (3.5); 2.2641 (1.1); 2.2528 (2.0); 2.2401 (2.2); 2.2128 (1.4); 2.1940 (2.2); 2.1891 (1.3); 2.1815 (1.7); 2.1751 (1.5); 2.1698 (1.8); 2.1626 (2.6); 2.1577 (1.7); 2.1510 (1.1); 2.1431 (1.6); 2.1383 (1.9); 2.1191 (0.9); 2.0710 (0.7); 1.7437 (1.1); 1.7320 (1.8); 1.7205 (2.4); 1.7097 (2.1); 1.7003 (2.2); 1.6888 (2.2); 1.6774 (1.5); 1.6647 (1.0); 0.0082 (0.4) I.1-160: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9248 (0.5); 7.9177 (4.2); 7.9129 (1.3); 7.9005 (1.3); 7.8955 (4.4); 7.1255 (1.3); 7.1049 (5.4); 7.0924 (5.8); 7.0718 (1.4); 7.0558 (0.5); 7.0487 (4.2); 7.0438 (1.3); 7.0314 (1.2); 7.0265 (4.0); 4.6448 (1.4); 4.6067 (1.6); 4.3549 (0.8); 4.3446 (2.0); 4.3352 (2.1); 4.3260 (1.1); 4.2461 (2.2); 4.2353 (2.8); 4.2243 (1.4); 4.0467 (1.6); 4.0083 (1.4); 3.8143 (16.0); 3.7137 (0.7); 3.7034 (0.8); 3.6930 (0.7); 3.6829 (0.5); 3.3260 (190.0); 2.7839 (0.9); 2.7738 (1.0); 2.7442 (1.2); 2.7340 (1.2); 2.5102 (25.0); 2.5058 (52.5); 2.5013 (71.9); 2.4968 (51.1); 2.4925 (23.7); 2.4832 (1.9); 2.4612 (1.3); 2.4432 (1.1); 2.4213 (1.1); 2.3840 (0.8); 2.3665 (0.6); 2.3611 (0.6); 2.3431 (0.6); 2.2587 (11.3); 2.2440 (0.9); 2.2302 (0.9); 2.2023 (0.5); 2.1889 (0.5); 2.1325 (0.5); 2.1013 (0.6); 1.7010 (0.6); 1.6900 (0.5); 1.6808 (0.5); 1.6689 (0.5); -0.0002 (1.7) I.1-161: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.7696 (3.0); 7.3869 (0.4); 7.3831 (0.4); 7.3665 (0.8); 7.3625 (0.9); 7.3565 (0.5); 7.3468 (0.6); 7.3406 (0.9); 7.3365 (0.8); 7.3202 (0.5); 7.3164 (0.5); 7.2145 (0.5); 7.2108 (0.6); 7.2017 (0.5); 7.1979 (0.7); 7.1945 (1.0); 7.1910 (1.0); 7.1818 (0.9); 7.1785 (1.0); 7.1745 (0.6); 7.1705 (0.6); 7.1615 (0.6); 7.1581 (0.6); 7.0835 (1.0); 7.0674 (1.3); 7.0643 (1.3); 7.0480 (0.7); 4.7358 (1.5); 4.6962 (1.8); 4.2472 (1.9); 4.2073 (1.6); 3.8457 (0.6); 3.8353 (0.9); 3.8250 (1.0); 3.8148 (0.9); 3.8047 (0.6); 3.3984 (16.0); 3.3400 (0.4); 3.1687 (6.8); 2.9508 (0.4); 2.9367 (1.0); 2.9344 (0.8); 2.9261 (0.6); 2.9187 (1.7); 2.9129 (0.6); 2.9067 (0.7); 2.9026 (1.0); 2.8996 (0.6); 2.8871 (0.5); 2.7563 (1.3); 2.7458 (1.3); 2.7184 (1.6); 2.7080 (1.6); 2.6698 (0.4); 2.5401 (0.5); 2.5233 (0.8); 2.5185 (1.2); 2.5099 (19.4); 2.5053 (42.5); 2.5007 (59.8); 2.4961 (43.2); 2.4915 (20.3); 2.4465 (1.9); 2.4249 (2.1); 2.4087 (1.6); 2.4033 (1.2); 2.3866 (1.9); 2.3627 (0.7); 2.3277 (0.4); 2.3030 (0.7); 2.2908 (0.8); 2.2788 (1.2); 2.2667 (1.2); 2.2616 (0.5); 2.2371 (0.8); 2.2252 (1.0); 2.2067 (0.8); 2.1950 (0.6); 2.1877 (0.5); 2.1825 (0.5); 2.1758 (1.0); 2.1712 (0.5); 2.1560 (0.5); 2.1516 (0.6); 2.0721 (0.4); 1.7893 (0.4); 1.7803 (0.7); 1.7687 (0.7); 1.7587 (0.8); 1.7504 (0.8); 1.7467 (0.5); 1.7388 (0.6); 1.7259 (0.5); 1.0795 (0.9); 1.0683 (8.4); 1.0642 (3.5); 1.0541 (3.5); 1.0497 (4.4); 1.0447 (2.3) I.1-162: 1H-NMR (400.0 MHz, d6-DMSO): δ= 11.8115 (2.9); 7.0842 (0.8); 7.0665 (1.7); 7.0473 (1.1); 6.9675 (1.1); 6.9643 (1.2); 6.9471 (1.8); 6.9303 (0.8); 6.9271 (0.8); 4.6937 (1.8); 4.6542 (2.1); 4.1785 (2.3); 4.1391 (2.0); 3.9644 (0.9); 3.8139 (0.8); 3.8034 (1.1); 3.7929 (1.3); 3.7827 (1.1); 3.7725 (0.8); 3.4807 (16.0); 3.2125 (36.5); 3.1689 (6.1); 2.7366 (1.7); 2.7262 (1.8); 2.6983 (2.2); 2.6879 (2.0); 2.5236 (1.2); 2.5189 (1.6); 2.5103 (22.0); 2.5057 (46.8); 2.5010 (64.2); 2.4964 (44.9); 2.4918 (20.1); 2.4242 (2.3); 2.4022 (2.7); 2.3858 (3.0); 2.3640 (2.8); 2.3434 (1.0); 2.2892 (1.0); 2.2767 (1.3); 2.2622 (10.2); 2.2575 (10.0); 2.2232 (0.9); 2.2118 (1.0); 2.1982 (0.7); 2.1795 (1.0); 2.1676 (0.7); 2.1603 (0.6); 2.1554 (0.7); 2.1482 (1.2); 2.1435 (0.6); 2.1284 (0.6); 2.1239 (0.8); 1.7645 (0.8); 1.7533 (0.9); 1.7430 (0.9); 1.7336 (1.0); 1.7222 (0.8); 1.7105 (0.6); -0.0002 (8.7) I.1-163: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.5739 (0.6); 7.5701 (0.6); 7.5538 (0.7); 7.5501 (0.6); 7.3639 (0.7); 7.3443 (1.3); 7.3245 (0.8); 7.2132 (0.6); 7.2095 (0.6); 4.6726 (0.6); 4.6315 (0.7); 4.2824 (0.7); 4.2412 (0.5); 3.5781 (16.0); 3.1684 (0.7); 2.5307 (0.6); 2.5233 (0.8); 2.5186 (1.2); 2.5100 (16.6); 2.5054 (35.6); 2.5008 (48.4); 2.4961 (33.4); 2.4915 (15.0); 2.2233 (0.8); 2.2011 (0.5); 2.1868 (0.5); -0.0002 (3.0) I.1-164: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.4616 (1.0); 7.4066 (0.5); 7.3796 (0.5); 4.6068 (0.5); 4.5678 (0.6); 4.1463 (0.7); 4.1072 (0.6); 3.7859 (0.3); 3.4370 (1.1); 2.7761 (16.0); 2.7187 (0.4); 2.7082 (0.4); 2.6809 (0.5); 2.6704 (0.5); 2.5102 (2.0); 2.5057 (4.4); 2.5011 (6.2); 2.4965 (4.6); 2.4921 (2.2); 2.3880 (0.4); 2.3638 (0.7); 2.3416 (0.5); 2.3259 (0.4); 2.3035 (0.5); 2.2907 (0.4); 2.2770 (0.4) I.1-166: 1H-NMR (400.0 MHz, d6-DMSO): δ= 11.8114 (5.2); 7.3902 (2.4); 7.3711 (6.4); 7.3531 (7.1); 7.3520 (7.4); 7.3458 (3.5); 7.3416 (6.2); 7.3369 (5.0); 7.3259 (1.3); 7.3207 (2.2); 7.3169 (1.5); 7.2910 (4.4); 7.2868 (6.8); 7.2833 (3.8); 7.2019 (2.7); 7.1980 (4.8); 7.1943 (2.6); 7.1840 (2.2); 7.1799 (3.8); 7.1762 (2.1); 4.6368 (4.2); 4.5976 (4.9); 4.1406 (4.8); 4.1013 (4.2); 3.9643 (0.8); 3.8345 (0.7); 3.8238 (1.5); 3.8131 (2.1); 3.8027 (2.4); 3.7929 (2.1); 3.7823 (1.6); 3.7718 (0.7); 3.3904 (46.2); 3.3395 (0.8); 3.2658 (0.6); 3.2163 (64.1); 3.1683 (16.0); 3.1657 (0.5); 2.7425 (3.1); 2.7317 (3.2); 2.7042 (3.8); 2.6934 (3.6); 2.6743 (0.8); 2.6696 (1.1); 2.6650 (0.8); 2.5546 (0.6); 2.5500 (1.1); 2.5453 (1.1); 2.5399 (1.3); 2.5337 (0.8); 2.5288 (1.0); 2.5232 (2.7); 2.5184 (3.8); 2.5098 (58.7); 2.5052 (126.6); 2.5005 (175.4); 2.4959 (123.5); 2.4913 (55.9); 2.4398 (1.1); 2.4217 (1.2); 2.4174 (1.2); 2.3985 (2.7); 2.3911 (4.1); 2.3797 (2.3); 2.3755 (2.3); 2.3692 (4.1); 2.3529 (3.8); 2.3310 (3.7); 2.3275 (1.7); 2.3195 (2.0); 2.3063 (2.2); 2.2954 (2.8); 2.2822 (2.7); 2.2779 (1.2); 2.2646 (0.9); 2.2535 (1.5); 2.2407 (1.5); 2.2020 (1.1); 2.1829 (1.7); 2.1781 (1.0); 2.1704 (1.3); 2.1637 (1.1); 2.1587 (1.4); 2.1512 (2.0); 2.1464 (1.2); 2.1397 (0.8); 2.1318 (1.2); 2.1270 (1.4); 2.1076 (0.7); 2.0718 (0.6); 1.7645 (0.9); 1.7521 (1.3); 1.7412 (1.8); 1.7308 (1.5); 1.7202 (1.5); 1.7093 (1.7); 1.6984 (1.0); 1.6855 (0.7); 0.0080 (1.0); 0.0039 (0.5); -0.0002 (33.7); -0.0085 (0.9) I.1-167: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5256 (1.1); 7.5194 (1.5); 7.3143 (2.5); 7.3089 (3.2); 7.2934 (6.3); 7.2902 (6.1); 7.2867 (6.1); 7.2669 (203.6); 7.2605 (281.8); 7.1667 (0.4); 7.1020 (0.4); 7.0381 (9.3); 7.0190 (8.2); 7.0029 (1.8); 6.9965 (2.7); 6.9796 (8.3); 6.9684 (11.6); 6.9638 (13.0); 6.9452 (11.2); 6.9238 (0.7); 5.5276 (1.0); 5.4726 (0.3); 5.4107 (4.8); 4.8360 (0.7); 4.7972 (0.7); 4.6733 (8.2); 4.6348 (9.8); 4.4463 (0.4); 4.3584 (1.6); 4.3209 (1.4); 4.2687 (9.5); 4.2308 (7.9); 4.1390 (0.8); 4.1009 (1.4); 4.0830 (0.7); 4.0731 (0.6); 4.0535 (1.6); 4.0396 (3.8); 4.0336 (4.0); 4.0266 (4.6); 4.0212 (5.6); 4.0142 (3.7); 4.0086 (4.2); 4.0018 (2.7); 3.9895 (1.4); 3.9167 (0.3); 3.9098 (0.4); 3.8912 (0.5); 3.8801 (0.4); 3.8699 (0.4); 3.8075 (0.6); 3.6642 (0.4); 3.6540 (4.5); 3.6479 (6.4); 3.4915 (0.3); 2.7359 (0.7); 2.7231 (0.8); 2.6940 (1.1); 2.6812 (1.9); 2.6695 (3.0); 2.6626 (4.3); 2.6533 (5.5); 2.6454 (5.3); 2.6362 (4.1); 2.6183 (0.8); 2.6022 (0.6); 2.5912 (0.8); 2.5660 (0.6); 2.5518 (1.6); 2.5331 (2.9); 2.5092 (5.2); 2.4905 (7.0); 2.4676 (4.8); 2.4604 (3.7); 2.4543 (5.9); 2.4456 (9.3); 2.4370 (7.9); 2.4322 (9.8); 2.4216 (4.8); 2.4157 (9.1); 2.4090 (8.1); 2.4016 (6.2); 2.3960 (7.9); 2.3879 (4.0); 2.3787 (2.3); 2.3733 (3.1); 2.3668 (1.5); 2.3612 (1.3); 2.3486 (1.8); 2.3336 (1.4); 2.3222 (2.4); 2.3172 (2.7); 2.2982 (4.4); 2.2933 (2.3); 2.2846 (3.6); 2.2795 (3.5); 2.2735 (3.5); 2.2659 (4.9); 2.2609 (3.0); 2.2466 (3.9); 2.2419 (3.0); 2.2223 (1.4); 2.1081 (4.6); 2.1027 (6.3); 2.0884 (4.7); 2.0828 (6.3); 2.0715 (4.1); 2.0660 (5.3); 2.0516 (3.8); 2.0462 (5.0); 2.0043 (0.3); 1.9404 (0.6); 1.8544 (0.4); 1.8152 (2.2); 1.8045 (3.2); 1.7956 (3.0); 1.7912 (3.8); 1.7830 (4.4); 1.7773 (3.7); 1.7716 (4.1); 1.7595 (2.8); 1.7482 (2.6); 1.7393 (1.4); 1.7337 (1.6); 1.5655 (56.0); 1.5603 (72.9); 1.2583 (0.7); 0.9113 (0.6); 0.8952 (0.6); 0.8835 (0.7); 0.7904 (2.6); 0.7843 (4.3); 0.7725 (12.4); 0.7681 (12.4); 0.7559 (14.5); 0.7453 (5.5); 0.7376 (4.7); 0.7202 (1.3); 0.7139 (1.1); 0.7071 (1.0); 0.6818 (0.5); 0.6642 (0.8); 0.6565 (0.7); 0.5201 (0.8); 0.4989 (1.4); 0.4940 (1.2); 0.4878 (1.2); 0.4680 (0.6); 0.4569 (3.0); 0.4389 (16.0); 0.4355 (16.0); 0.4292 (15.1); 0.4131 (3.8); 0.4028 (1.1); 0.1458 (0.4); 0.0144 (1.8); 0.0063 (68.5); 0.0000 (97.2) I.1-168: 1H-NMR (400.0 MHz, d6-DMSO): δ= 3.3340 (1.0); 3.1172 (1.3); 3.0788 (1.8); 3.0606 (5.7); 3.0423 (5.9); 3.0242 (1.8); 2.9097 (1.5); 2.6735 (1.5); 2.5250 (0.6); 2.5204 (0.8); 2.5117 (7.4); 2.5071 (15.4); 2.5026 (20.8); 2.4980 (14.4); 2.4934 (6.2); 1.2051 (7.6); 1.1869 (16.0); 1.1687 (7.3); 0.9789 (0.8); -0.0002 (5.5) I.1-169: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.5442 (1.2); 8.2871 (1.5); 8.2668 (1.6); 7.2211 (2.1); 7.2072 (7.0); 7.1951 (1.8); 7.1769 (1.3); 7.1695 (1.3); 7.1583 (2.0); 7.1510 (1.9); 7.1369 (1.4); 7.1168 (2.4); 7.0962 (1.2); 4.7616 (2.3); 4.7224 (2.5); 4.3034 (1.0); 4.2520 (0.8); 4.2361 (1.0); 4.0907 (2.1); 4.0511 (1.9); 3.6863 (1.1); 3.3130 (142.7); 2.6743 (2.4); 2.6697 (2.9); 2.6653 (2.1); 2.6251 (1.6); 2.6087 (3.7); 2.5897 (3.9); 2.5722 (1.8); 2.5400 (3.0); 2.5232 (8.3); 2.5185 (12.1); 2.5098 (184.3); 2.5053 (404.0); 2.5007 (565.0); 2.4960 (393.6); 2.4915 (174.3); 2.4089 (1.1); 2.3875 (1.0); 2.3683 (1.4); 2.3321 (2.5); 2.3275 (3.3); 2.3226 (2.2); 2.2909 (1.8); 2.2690 (1.8); 2.2571 (2.0); 2.2345 (1.4); 2.0851 (1.0); 2.0731 (1.2); 2.0421 (0.9); 2.0123 (0.9); 1.7541 (1.0); 1.6073 (0.9); 1.5010 (2.1); 1.4874 (2.4); 1.4656 (1.4); 1.1746 (1.4); 1.1557 (3.0); 1.1419 (7.1); 1.1231 (16.0); 1.1042 (6.9); 0.8911 (9.6); 0.8747 (9.5); 0.8230 (9.9); 0.8068 (9.5); 0.0080 (6.4); -0.0002 (256.0); -0.0086 (7.9); -0.1496 (0.9) I.1-170: 1H-NMR (400.0 MHz, d6-DMSO): δ= 6.9334 (0.9); 6.9132 (3.3); 6.8971 (3.6); 6.8918 (0.7); 6.8766 (1.0); 4.4483 (0.9); 4.4101 (1.0); 3.8478 (1.1); 3.8096 (0.9); 3.6126 (1.7); 3.6080 (1.8); 3.5942 (1.8); 3.5899 (1.8); 3.5044 (0.5); 3.4941 (0.6); 3.4839 (0.5); 3.2408 (8.9); 2.5391 (0.7); 2.5288 (0.7); 2.4996 (0.9); 2.4893 (0.9); 2.2962 (5.6); 2.2917 (11.8); 2.2871 (16.0); 2.2825 (11.2); 2.2780 (5.1); 2.2355 (1.0); 2.2138 (1.1); 2.1960 (0.8); 2.1915 (0.6); 2.1742 (1.1); 2.0607 (7.5); 2.0522 (0.9); 2.0383 (0.6); 0.8135 (0.6); 0.2847 (1.4); 0.2801 (1.5); 0.2754 (0.6); 0.2697 (0.6); 0.2644 (1.5); 0.2600 (1.4); 0.2497 (0.5); 0.0261 (0.6); 0.0155 (1.6); 0.0116 (1.5); 0.0038 (1.4); -0.0002 (1.7); -0.2157 (1.5) I.1-171: 1H-NMR (400.0 MHz, d6-DMSO): δ= 11.8025 (3.0); 7.4101 (0.8); 7.4037 (7.4); 7.3987 (2.3); 7.3875 (2.7); 7.3824 (10.0); 7.3761 (1.1); 7.2665 (1.0); 7.2603 (7.5); 7.2552 (2.2); 7.2438 (1.9); 7.2389 (5.5); 7.2325 (0.6); 4.6235 (2.5); 4.5845 (2.9); 4.1260 (2.8); 4.0871 (2.4); 3.8018 (0.9); 3.7912 (1.2); 3.7810 (1.4); 3.7710 (1.2); 3.7605 (0.9); 3.4435 (9.0); 3.3856 (0.7); 3.2134 (36.0); 3.1682 (16.0); 2.7214 (1.8); 2.7104 (1.8); 2.6830 (2.2); 2.6721 (2.3); 2.6651 (0.5); 2.5398 (0.5); 2.5341 (0.6); 2.5297 (0.8); 2.5232 (1.6); 2.5184 (2.1); 2.5098 (32.4); 2.5052 (69.0); 2.5006 (94.5); 2.4959 (65.7); 2.4913 (29.5); 2.4142 (0.6); 2.4095 (0.6); 2.3909 (1.5); 2.3773 (2.4); 2.3725 (1.5); 2.3683 (1.2); 2.3556 (2.3); 2.3492 (1.2); 2.3391 (1.9); 2.3321 (0.6); 2.3273 (0.7); 2.3225 (0.6); 2.3174 (1.9); 2.3021 (1.0); 2.2889 (1.2); 2.2779 (1.6); 2.2647 (1.5); 2.2604 (0.7); 2.2474 (0.5); 2.2360 (0.9); 2.2233 (0.9); 2.1854 (0.6); 2.1663 (1.0); 2.1615 (0.5); 2.1539 (0.8); 2.1472 (0.6); 2.1421 (0.8); 2.1347 (1.2); 2.1298 (0.7); 2.1152 (0.7); 2.1104 (0.8); 1.7521 (0.5); 1.7399 (0.8); 1.7289 (1.0); 1.7184 (0.9); 1.7080 (0.9); 1.6970 (1.0); 1.6861 (0.6); -0.0002 (9.2) I.1-174: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.8034 (1.4); 7.4084 (0.5); 7.3928 (0.6); 7.3885 (1.0); 7.3733 (1.0); 7.3691 (0.8); 7.3535 (0.7); 7.1181 (0.4); 7.1114 (0.5); 7.0958 (0.8); 7.0901 (0.9); 7.0767 (1.6); 7.0562 (1.7); 7.0300 (0.7); 7.0254 (0.8); 4.6518 (1.3); 4.6125 (1.5); 4.1514 (1.5); 4.1122 (1.3); 3.8286 (0.4); 3.8182 (0.6); 3.8077 (0.8); 3.7975 (0.6); 3.7875 (0.5); 3.3880 (0.4); 3.3380 (84.3); 3.2887 (0.5); 3.2119 (16.0); 2.7363 (0.9); 2.7254 (0.9); 2.6980 (1.1); 2.6871 (1.1); 2.5240 (0.5); 2.5192 (0.6); 2.5106 (12.5); 2.5060 (27.9); 2.5015 (39.4); 2.4969 (28.4); 2.4923 (13.3); 2.4215 (0.4); 2.4175 (0.4); 2.3961 (1.4); 2.3743 (1.5); 2.3575 (1.5); 2.3358 (1.0); 2.3284 (0.3); 2.3216 (0.6); 2.3082 (0.6); 2.2973 (0.8); 2.2842 (0.8); 2.2555 (0.4); 2.2427 (0.4); 2.2093 (0.3); 2.1904 (0.5); 2.1781 (0.4); 2.1712 (0.3); 2.1663 (0.4); 2.1589 (0.6); 2.1539 (0.4); 2.1395 (0.4); 2.1347 (0.4); 1.7537 (0.4); 1.7424 (0.5); 1.7323 (0.5); 1.7218 (0.5); 1.7107 (0.5) I.1-175: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.7756 (2.3); 7.4771 (3.8); 7.4546 (3.9); 7.1315 (1.7); 7.1110 (6.6); 7.0979 (7.0); 7.0772 (1.6); 6.8600 (4.4); 6.8375 (4.1); 4.6493 (1.7); 4.6110 (1.9); 4.3084 (1.0); 4.2978 (2.6); 4.2867 (2.8); 4.2767 (1.2); 4.0989 (2.3); 4.0877 (3.7); 4.0763 (1.8); 4.0517 (2.0); 4.0137 (1.8); 3.7263 (0.6); 3.7162 (0.9); 3.7055 (1.1); 3.6957 (1.0); 3.6852 (0.7); 3.3670 (112.0); 3.1677 (0.8); 2.7819 (1.1); 2.7718 (1.2); 2.7422 (1.5); 2.7321 (1.4); 2.5100 (32.8); 2.5058 (67.4); 2.5014 (91.0); 2.4969 (64.3); 2.4764 (1.7); 2.4544 (1.5); 2.4364 (1.4); 2.4147 (1.7); 2.3910 (1.1); 2.3726 (0.8); 2.3674 (0.8); 2.3494 (0.7); 2.3284 (0.6); 2.2644 (13.8); 2.2481 (1.1); 2.2345 (1.1); 2.2062 (0.6); 2.1933 (0.7); 2.1556 (0.5); 2.1369 (0.6); 2.1241 (0.5); 2.1058 (0.8); 2.0812 (0.5); 1.9988 (16.0); 1.7158 (0.5); 1.7042 (0.7); 1.6934 (0.6); 1.6839 (0.7); 1.6723 (0.6); - 0.0002 (2.1) I.1-177: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6552 (3.3); 8.6402 (6.1); 8.6239 (3.2); 7.3799 (2.4); 7.3761 (2.5); 7.3557 (5.5); 7.3340 (5.4); 7.3132 (2.9); 7.3094 (2.8); 7.2088 (3.2); 7.2047 (3.4); 7.1959 (3.3); 7.1887 (5.8); 7.1849 (6.2); 7.1761 (5.7); 7.1724 (6.2); 7.1685 (4.0); 7.1644 (3.7); 7.1556 (3.2); 7.1518 (3.4); 7.0798 (5.6); 7.0637 (7.7); 7.0444 (4.1); 4.7384 (8.9); 4.6989 (10.4); 4.2375 (11.5); 4.1977 (9.9); 3.9285 (2.6); 3.9067 (7.8); 3.9038 (7.8); 3.8879 (8.0); 3.8821 (8.2); 3.8790 (7.8); 3.8660 (7.6); 3.8631 (7.8); 3.8575 (3.4); 3.8383 (3.1); 3.8231 (4.0); 3.8123 (5.5); 3.8022 (6.9); 3.7921 (5.5); 3.7816 (3.9); 3.7713 (1.9); 3.3577 (1.2); 3.3081 (337.7); 3.2588 (2.5); 3.1685 (0.8); 2.6741 (2.9); 2.6693 (4.1); 2.6647 (2.8); 2.6377 (8.4); 2.6265 (8.6); 2.6022 (10.6); 2.5910 (10.0); 2.5502 (1.9); 2.5395 (2.6); 2.5228 (9.6); 2.5181 (13.9); 2.5095 (229.2); 2.5049 (503.0); 2.5002 (704.9); 2.4956 (486.0); 2.4910 (215.3); 2.4552 (3.4); 2.4504 (4.5); 2.4458 (3.2); 2.4106 (2.3); 2.3909 (3.2); 2.3686 (6.6); 2.3490 (6.2); 2.3315 (4.3); 2.3248 (15.4); 2.3027 (10.6); 2.2892 (11.2); 2.2776 (6.7); 2.2669 (16.0); 2.2535 (7.9); 2.2359 (2.9); 2.2248 (4.3); 2.2119 (4.1); 2.1591 (2.8); 2.1397 (4.8); 2.1352 (2.9); 2.1273 (3.5); 2.1203 (3.0); 2.1157 (4.2); 2.1080 (5.7); 2.1036 (3.3); 2.0966 (2.1); 2.0884 (3.2); 2.0839 (4.3); 2.0644 (2.0); 1.7623 (2.3); 1.7499 (3.5); 1.7388 (4.7); 1.7282 (4.0); 1.7174 (4.0); 1.7071 (4.0); 1.6961 (2.6); 1.6834 (1.7); 0.0081 (1.7); -0.0002 (63.7); -0.0085 (1.7) I.1-178: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0421 (3.8); 7.3784 (1.6); 7.3745 (1.7); 7.3583 (3.3); 7.3541 (3.6); 7.3481 (1.9); 7.3382 (2.2); 7.3319 (3.5); 7.3119 (1.9); 7.3081 (1.9); 7.2073 (2.1); 7.2033 (2.2); 7.1945 (2.1); 7.1875 (3.8); 7.1837 (4.0); 7.1747 (3.7); 7.1710 (4.1); 7.1672 (2.5); 7.1630 (2.4); 7.1543 (2.1); 7.1505 (2.3); 7.1265 (0.6); 7.1158 (0.8); 7.0740 (3.9); 7.0580 (5.2); 7.0385 (2.8); 4.7382 (6.0); 4.6989 (6.8); 4.2292 (7.5); 4.1894 (6.5); 3.8099 (1.2); 3.7986 (2.3); 3.7885 (3.6); 3.7783 (4.6); 3.7680 (3.6); 3.7582 (2.4); 3.7472 (1.3); 3.3987 (1.0); 3.3669 (1.3); 3.3169 (338.3); 3.3009 (29.3); 3.2875 (18.9); 3.2756 (1.7); 3.2691 (2.6); 3.2657 (2.4); 3.2524 (0.6); 3.2252 (183.9); 3.1996 (6.6); 3.1858 (16.0); 3.1718 (13.6); 3.1572 (4.0); 3.0471 (1.0); 2.6743 (1.6); 2.6696 (2.5); 2.6651 (1.6); 2.5505 (0.9); 2.5400 (1.5); 2.5231 (10.3); 2.5185 (8.7); 2.5098 (139.7); 2.5052 (300.9); 2.5006 (423.9); 2.4960 (294.5); 2.4914 (131.5); 2.4765 (8.2); 2.4558 (2.3); 2.4513 (2.8); 2.4467 (2.0); 2.4045 (1.7); 2.3815 (2.1); 2.3618 (4.4); 2.3420 (4.1); 2.3320 (2.2); 2.3274 (2.9); 2.3191 (3.9); 2.2787 (4.3); 2.2658 (4.3); 2.2547 (5.3); 2.2417 (5.2); 2.2371 (2.4); 2.2242 (8.8); 2.2128 (3.2); 2.2029 (7.6); 2.1894 (5.9); 2.1682 (5.6); 2.1407 (2.0); 2.1212 (3.3); 2.1168 (2.0); 2.1091 (2.3); 2.1019 (2.0); 2.0973 (2.9); 2.0896 (4.0); 2.0851 (2.4); 2.0775 (1.4); 2.0700 (2.2); 2.0654 (3.0); 2.0458 (1.3); 1.7752 (1.6); 1.7628 (2.4); 1.7520 (3.3); 1.7417 (2.8); 1.7308 (2.7); 1.7204 (3.0); 1.7095 (1.8); 1.6966 (1.3); 0.0080 (0.8); -0.0002 (33.1); -0.0086 (0.9) I.1-179: 1H-NMR (400.1 MHz, d6-DMSO): δ= 6.8483 (0.6); 6.8401 (0.6); 6.8321 (2.3); 6.8242 (0.7); 6.8158 (0.7); 6.8096 (0.7); 6.7932 (2.1); 6.7868 (0.7); 6.7766 (0.7); 5.7925 (3.6); 5.7539 (3.4); 5.6221 (0.3); 5.5896 (0.8); 5.5842 (1.0); 5.5797 (1.4); 5.5763 (1.0); 5.5704 (0.9); 3.4324 (0.8); 3.3076 (12.1); 3.1691 (1.1); 2.9993 (3.5); 2.9952 (2.6); 2.9898 (3.0); 2.9861 (3.3); 2.6740 (0.7); 2.6695 (0.9); 2.6653 (0.8); 2.6481 (0.4); 2.6405 (0.4); 2.6223 (0.4); 2.6060 (0.8); 2.6017 (0.7); 2.5578 (0.3); 2.5532 (0.3); 2.5332 (0.3); 2.5228 (1.8); 2.5094 (52.8); 2.5050 (109.3); 2.5006 (147.2); 2.4962 (105.1); 2.4919 (49.5); 2.4583 (0.4); 2.4536 (0.4); 2.4489 (0.3); 2.3902 (11.6); 2.3836 (16.0); 2.3321 (0.7); 2.3275 (0.9); 2.3227 (0.7); 2.3187 (0.4); 0.0081 (0.8); 0.0010 (20.4); 0.0000 (20.9) I.1-180: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4095 (4.9); 7.3744 (2.0); 7.3575 (4.0); 7.3538 (4.5); 7.3317 (4.4); 7.3112 (2.4); 7.2076 (2.6); 7.2037 (2.6); 7.1949 (2.6); 7.1877 (4.6); 7.1840 (5.0); 7.1750 (4.5); 7.1715 (4.9); 7.1673 (3.0); 7.1634 (2.9); 7.1546 (2.7); 7.1510 (2.8); 7.0804 (4.6); 7.0644 (6.4); 7.0449 (3.4); 4.7434 (7.4); 4.7041 (8.4); 4.2213 (9.2); 4.1818 (8.0); 3.8383 (15.1); 3.8320 (15.9); 3.8243 (16.0); 3.8181 (14.8); 3.8006 (3.0); 3.7903 (4.6); 3.7802 (5.6); 3.7698 (4.5); 3.7597 (3.0); 3.7490 (1.6); 3.4184 (0.8); 3.3165 (259.7); 3.2688 (2.2); 3.2161 (0.6); 3.1685 (3.5); 3.0919 (11.4); 2.6741 (1.9); 2.6695 (2.8); 2.6646 (2.0); 2.5476 (7.1); 2.5361 (7.4); 2.5229 (6.9); 2.5182 (10.8); 2.5096 (165.2); 2.5050 (354.4); 2.5003 (499.5); 2.4957 (342.2); 2.4911 (152.5); 2.4552 (2.5); 2.4508 (3.1); 2.4091 (2.2); 2.3865 (2.6); 2.3663 (5.4); 2.3464 (5.1); 2.3364 (1.6); 2.3319 (2.5); 2.3229 (5.6); 2.2790 (4.1); 2.2663 (5.0); 2.2549 (6.4); 2.2422 (6.4); 2.2353 (9.2); 2.2246 (2.7); 2.2135 (11.0); 2.2003 (10.0); 2.1786 (6.6); 2.1487 (2.4); 2.1292 (4.1); 2.1171 (2.9); 2.1098 (2.4); 2.1053 (3.4); 2.0977 (4.7); 2.0932 (2.7); 2.0856 (1.7); 2.0778 (2.7); 2.0735 (3.8); 2.0536 (1.5); 1.7651 (1.9); 1.7534 (2.9); 1.7422 (3.6); 1.7318 (3.5); 1.7206 (3.3); 1.7104 (3.3); 1.6990 (2.2); 1.6872 (1.5); 0.0080 (1.3); -0.0002 (45.0); -0.0085 (1.4) I.1-181: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3390 (0.7); 8.3253 (1.3); 8.3110 (0.7); 7.3583 (1.0); 7.3357 (1.0); 7.3156 (0.6); 7.2061 (1.8); 7.2014 (2.0); 7.1897 (5.0); 7.1870 (7.1); 7.1838 (4.8); 7.1730 (4.4); 7.1703 (4.5); 7.1599 (2.7); 7.1546 (2.2); 7.1451 (1.2); 7.1393 (1.2); 7.1345 (0.7); 7.1204 (0.6); 7.0765 (1.1); 7.0602 (1.5); 7.0410 (0.7); 4.7418 (1.4); 4.7013 (1.7); 4.2623 (2.5); 4.2542 (2.6); 4.2485 (2.7); 4.2401 (3.8); 4.2002 (1.6); 3.8266 (0.6); 3.8162 (0.8); 3.8060 (1.0); 3.7960 (0.9); 3.7857 (0.6); 3.3424 (236.4); 3.2908 (1.6); 3.1672 (2.3); 3.1529 (2.5); 2.6746 (1.3); 2.6700 (1.8); 2.6654 (1.3); 2.6229 (1.4); 2.6038 (5.3); 2.5907 (1.6); 2.5851 (5.0); 2.5665 (2.8); 2.5549 (0.9); 2.5495 (0.7); 2.5448 (1.0); 2.5402 (2.2); 2.5233 (5.0); 2.5187 (7.7); 2.5100 (103.3); 2.5055 (221.3); 2.5008 (305.4); 2.4962 (213.2); 2.4916 (94.7); 2.4596 (0.6); 2.4548 (1.0); 2.4501 (1.6); 2.4456 (1.4); 2.4018 (0.6); 2.3829 (0.7); 2.3599 (1.2); 2.3369 (1.7); 2.3324 (1.8); 2.3277 (2.1); 2.3229 (1.6); 2.3183 (1.5); 2.2834 (1.9); 2.2749 (1.6); 2.2617 (2.0); 2.2488 (2.0); 2.2265 (1.5); 2.2090 (0.7); 2.1616 (0.5); 2.1422 (0.8); 2.1300 (0.6); 2.1180 (0.7); 2.1106 (1.0); 2.0866 (0.8); 2.0730 (1.0); 1.7871 (0.6); 1.7766 (0.8); 1.7663 (0.7); 1.7550 (0.7); 1.7449 (0.8); 1.2098 (1.5); 1.1936 (1.5); 1.1566 (7.0); 1.1378 (16.0); 1.1189 (6.8); 0.0080 (1.2); -0.0002 (41.8); -0.0085 (1.2) I.1-182: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0946 (0.7); 7.4655 (3.6); 7.3567 (0.5); 7.3529 (0.6); 7.3307 (0.6); 7.1828 (0.6); 7.1790 (0.7); 7.1698 (0.6); 7.1665 (0.7); 7.0682 (0.6); 7.0520 (0.8); 4.7284 (0.9); 4.6890 (1.1); 4.2126 (1.2); 4.1730 (1.0); 4.0086 (1.9); 4.0026 (1.9); 3.9997 (2.2); 3.9958 (1.9); 3.9903 (2.0); 3.9815 (3.9); 3.9633 (4.0); 3.9452 (1.3); 3.7911 (0.6); 3.7811 (0.7); 3.7711 (0.6); 3.4698 (8.3); 2.5229 (1.4); 2.5185 (1.2); 2.5098 (16.8); 2.5052 (35.8); 2.5006 (50.3); 2.4960 (34.8); 2.4913 (15.5); 2.4763 (1.0); 2.3411 (0.7); 2.3224 (0.8); 2.2987 (0.5); 2.2722 (0.5); 2.2592 (0.6); 2.2482 (0.8); 2.2352 (0.8); 2.2118 (1.1); 2.2064 (0.5); 2.1902 (1.1); 2.1771 (0.9); 2.1694 (1.1); 2.1554 (0.8); 2.1195 (0.5); 2.0880 (0.6); 2.0638 (16.0); 1.7505 (0.5); 1.3113 (5.1); 1.2932 (11.7); 1.2750 (5.0); 1.2495 (0.7); -0.0002 (3.5) I.1-183: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5312 (1.1); 8.5178 (0.6); 8.2879 (3.0); 8.2828 (3.0); 7.7049 (2.0); 7.6986 (1.9); 7.6844 (2.4); 7.6781 (2.3); 7.4784 (3.8); 7.4579 (3.2); 7.1343 (2.5); 7.1143 (6.6); 7.0907 (7.4); 7.0704 (2.6); 4.6568 (2.0); 4.6187 (2.2); 4.2673 (2.3); 4.2588 (2.6); 4.2526 (2.5); 4.2446 (2.3); 3.9968 (2.2); 3.9588 (2.0); 3.7359 (0.7); 3.7251 (0.9); 3.7145 (1.1); 3.7048 (0.9); 3.6940 (0.7); 3.3460 (56.6); 3.1687 (0.6); 2.5892 (1.4); 2.5783 (1.4); 2.5542 (1.8); 2.5431 (1.6); 2.5232 (1.2); 2.5184 (1.8); 2.5098 (29.4); 2.5052 (63.4); 2.5006 (88.2); 2.4960 (61.4); 2.4914 (27.5); 2.3611 (0.5); 2.3374 (1.3); 2.3274 (0.6); 2.3185 (1.2); 2.2959 (1.0); 2.2728 (16.0); 2.2545 (1.2); 2.2444 (1.4); 2.2305 (1.4); 2.2126 (0.6); 2.2031 (2.1); 2.1886 (0.7); 2.1810 (1.6); 2.1685 (1.4); 2.1460 (1.3); 2.0716 (0.7); 2.0529 (0.7); 2.0405 (0.6); 2.0288 (0.7); 2.0214 (0.9); 1.9971 (0.7); 1.7027 (0.6); 1.6915 (0.8); 1.6813 (0.7); 1.6697 (0.6); 1.6594 (0.7); -0.0002 (0.6) I.1-184: 1H-NMR (400.6 MHz, d6-DMSO): δ= 7.5903 (6.8); 7.5867 (7.3); 7.5704 (8.7); 7.5667 (8.3); 7.3737 (8.6); 7.3541 (16.0); 7.3343 (9.2); 7.1940 (7.4); 7.1904 (7.7); 7.1746 (6.4); 7.1710 (6.2); 7.1587 (3.7); 7.0268 (7.6); 6.8950 (3.8); 4.6609 (6.9); 4.6192 (8.3); 4.2949 (8.1); 4.2532 (6.6); 3.8920 (1.6); 3.8824 (2.6); 3.8725 (3.4); 3.8630 (3.8); 3.8506 (3.4); 3.8410 (3.0); 3.4559 (5.6); 3.1673 (3.0); 2.7995 (4.0); 2.7899 (4.0); 2.7603 (5.0); 2.7507 (4.8); 2.6749 (1.5); 2.6703 (2.0); 2.6656 (1.6); 2.5238 (8.8); 2.5106 (101.5); 2.5060 (207.0); 2.5015 (282.6); 2.4969 (195.7); 2.4923 (88.3); 2.4775 (6.0); 2.4615 (3.1); 2.4547 (4.7); 2.4389 (4.6); 2.4209 (3.6); 2.4159 (3.5); 2.4014 (1.5); 2.3879 (1.4); 2.3391 (2.8); 2.3330 (2.1); 2.3282 (4.0); 2.3152 (4.7); 2.3037 (4.8); 2.2748 (5.9); 2.2692 (4.3); 2.2621 (3.0); 2.2560 (2.2); 2.2440 (3.5); 2.2314 (1.2); 2.2247 (2.0); 2.2196 (1.9); 2.2002 (1.0); 2.0857 (2.0); 2.0736 (3.2); 1.8267 (0.9); 1.8019 (2.3); 1.7934 (2.4); 1.7837 (2.8); 1.7765 (1.9); 1.7712 (2.0); 1.7632 (1.8); 1.7521 (2.0); 1.7408 (1.2); 1.3240 (0.5); 0.0080 (1.2); -0.0002 (31.2); -0.0085 (0.8) I.1-185: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1473 (2.1); 7.1271 (6.6); 7.1088 (7.4); 7.0883 (2.3); 4.8808 (0.7); 4.8652 (2.0); 4.8495 (2.7); 4.8339 (2.0); 4.8182 (0.8); 4.6551 (1.9); 4.6168 (2.2); 4.0517 (2.2); 4.0134 (2.0); 3.7185 (0.7); 3.7081 (1.1); 3.6976 (1.2); 3.6875 (1.1); 3.6770 (0.8); 3.4114 (1.0); 3.3756 (116.5); 2.7000 (1.6); 2.6899 (1.7); 2.6713 (0.5); 2.6609 (2.2); 2.6507 (2.0); 2.5248 (0.8); 2.5200 (1.4); 2.5114 (28.3); 2.5069 (61.2); 2.5023 (83.4); 2.4977 (58.8); 2.4931 (26.8); 2.3906 (3.2); 2.3689 (2.6); 2.3514 (2.1); 2.3296 (2.1); 2.3246 (0.5); 2.2909 (0.9); 2.2756 (16.0); 2.2665 (1.8); 2.2523 (1.4); 2.2245 (0.7); 2.2109 (0.8); 2.1694 (0.5); 2.1501 (0.7); 2.1378 (0.6); 2.1320 (0.5); 2.1254 (0.6); 2.1197 (0.8); 2.1134 (0.6); 2.1001 (0.6); 2.0938 (0.6); 2.0753 (0.5); 1.7055 (0.6); 1.6943 (0.9); 1.6869 (0.5); 1.6834 (0.6); 1.6739 (0.7); 1.6697 (0.5); 1.6623 (0.8); 1.1504 (12.6); 1.1453 (12.8); 1.1347 (12.6); 1.1297 (12.7); -0.0002 (9.1) I.1-186: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1468 (2.2); 7.1268 (6.2); 7.1053 (5.9); 7.0849 (2.0); 5.7713 (0.8); 5.7455 (1.2); 5.7284 (1.2); 5.7026 (0.9); 5.1026 (0.5); 5.0986 (1.3); 5.0938 (1.6); 5.0899 (0.6); 5.0555 (1.2); 5.0508 (2.0); 5.0482 (1.7); 5.0434 (1.2); 5.0257 (0.6); 5.0226 (1.3); 5.0178 (1.1); 4.6542 (1.6); 4.6159 (1.8); 4.0472 (2.3); 4.0431 (2.8); 4.0262 (5.1); 4.0096 (4.4); 3.7129 (0.6); 3.7023 (0.9); 3.6916 (1.0); 3.6815 (0.9); 3.6713 (0.6); 3.3891 (1.6); 3.3796 (1.2); 3.3722 (2.2); 3.3389 (363.2); 3.3104 (1.4); 3.3017 (1.1); 3.1667 (0.8); 2.7378 (1.2); 2.7278 (1.2); 2.6983 (1.5); 2.6882 (1.4); 2.6760 (1.2); 2.6712 (1.4); 2.6667 (1.2); 2.5568 (0.8); 2.5521 (0.8); 2.5471 (0.7); 2.5415 (1.2); 2.5363 (1.0); 2.5318 (1.2); 2.5245 (3.7); 2.5199 (5.4); 2.5112 (74.0); 2.5067 (155.1); 2.5021 (211.4); 2.4975 (150.0); 2.4930 (67.8); 2.4282 (1.8); 2.4166 (0.9); 2.4063 (1.7); 2.3889 (1.9); 2.3743 (1.0); 2.3669 (1.9); 2.3501 (0.8); 2.3380 (0.5); 2.3335 (1.0); 2.3289 (1.4); 2.3244 (1.0); 2.3197 (0.5); 2.3043 (1.0); 2.2911 (1.8); 2.2876 (3.2); 2.2845 (2.7); 2.2757 (16.0); 2.2612 (1.6); 2.2546 (1.1); 2.2473 (1.4); 2.2304 (0.7); 2.2192 (0.9); 2.2058 (1.0); 2.1411 (0.6); 2.1283 (0.6); 2.1223 (0.6); 2.1160 (0.7); 2.1099 (0.8); 2.1039 (0.5); 2.0904 (0.6); 2.0755 (0.5); 1.7149 (0.5); 1.7022 (0.7); 1.6907 (0.9); 1.6796 (0.7); 1.6702 (0.7); 1.6588 (0.8); 0.0080 (0.8); -0.0002 (28.0); -0.0085 (0.8) I.1-188: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8853 (0.8); 7.3594 (0.6); 7.3554 (0.7); 7.3334 (0.7); 7.3295 (0.6); 7.1881 (0.7); 7.1844 (0.8); 7.1754 (0.7); 7.1718 (0.8); 7.0705 (0.7); 7.0543 (1.0); 7.0511 (0.9); 7.0350 (0.5); 4.7320 (1.1); 4.6922 (1.3); 4.2348 (1.4); 4.1951 (1.2); 3.7968 (0.6); 3.7865 (0.9); 3.7764 (0.6); 3.0530 (0.5); 3.0460 (0.5); 3.0348 (1.3); 3.0277 (1.1); 3.0208 (1.2); 3.0140 (1.3); 3.0022 (0.6); 2.9960 (0.6); 2.5117 (5.5); 2.5072 (12.1); 2.5025 (17.0); 2.4979 (12.6); 2.4933 (5.4); 2.4853 (1.1); 2.4623 (1.2); 2.4504 (1.2); 2.3572 (0.8); 2.3381 (0.8); 2.3344 (0.8); 2.3152 (0.6); 2.2891 (0.6); 2.2755 (0.8); 2.2651 (1.0); 2.2516 (0.9); 2.1893 (1.2); 2.1682 (1.2); 2.1545 (1.1); 2.1334 (1.1); 2.1259 (0.6); 2.1019 (0.5); 2.0944 (0.7); 2.0703 (0.5); 1.7397 (0.6); 1.7293 (0.5); 1.7078 (0.6); 1.5512 (0.8); 1.5344 (1.1); 1.5176 (1.0); 1.5009 (0.5); 1.2729 (1.4); 1.2550 (3.4); 1.2372 (3.3); 1.2193 (1.1); 0.8541 (16.0); 0.8375 (15.3); -0.0002 (1.9) I.1-189: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5560 (5.9); 7.5530 (6.1); 7.5360 (6.4); 7.5330 (6.6); 7.5212 (0.8); 7.2782 (2.7); 7.2751 (2.8); 7.2623 (132.8); 7.2565 (6.9); 7.2413 (5.8); 7.2381 (5.7); 7.2110 (6.1); 7.2064 (7.5); 7.1920 (3.7); 7.1873 (3.4); 7.1267 (4.2); 7.1219 (4.0); 7.1087 (5.2); 7.1068 (5.2); 7.1038 (4.8); 7.1021 (4.9); 7.0948 (3.4); 7.0887 (3.5); 7.0838 (4.3); 7.0789 (2.3); 7.0762 (2.5); 7.0693 (4.4); 7.0624 (1.3); 7.0578 (1.8); 7.0500 (8.0); 7.0431 (7.7); 7.0397 (5.8); 7.0348 (10.0); 7.0264 (4.3); 7.0241 (3.8); 7.0140 (0.8); 7.0073 (0.7); 6.9982 (0.7); 5.5102 (2.0); 5.2991 (0.7); 4.8492 (3.9); 4.8456 (3.9); 4.8104 (4.5); 4.8068 (4.4); 4.2368 (5.8); 4.1981 (5.1); 3.9487 (0.9); 3.9377 (2.0); 3.9267 (2.4); 3.9177 (2.5); 3.9154 (2.6); 3.9065 (2.4); 3.8955 (2.1); 3.8846 (1.0); 3.5526 (2.5); 3.5480 (2.4); 3.5348 (6.3); 3.5309 (5.6); 3.5199 (5.5); 3.5160 (6.9); 3.5024 (2.7); 3.4989 (2.8); 2.9729 (8.0); 2.9556 (16.0); 2.9382 (7.2); 2.6001 (4.1); 2.5894 (4.1); 2.5640 (4.7); 2.5532 (4.6); 2.5196 (0.9); 2.5010 (1.2); 2.4977 (1.1); 2.4771 (3.0); 2.4580 (2.7); 2.4547 (2.5); 2.4347 (2.5); 2.4174 (3.0); 2.4029 (3.6); 2.3933 (4.2); 2.3789 (4.2); 2.3746 (1.5); 2.3601 (1.3); 2.3503 (2.0); 2.3361 (1.9); 2.2634 (1.6); 2.2443 (2.5); 2.2394 (1.5); 2.2307 (2.0); 2.2252 (1.6); 2.2201 (2.1); 2.2116 (2.8); 2.2065 (1.8); 2.2012 (1.2); 2.1925 (1.7); 2.1873 (2.2); 2.1683 (1.2); 2.1321 (5.4); 2.1094 (5.3); 2.0959 (4.8); 2.0733 (4.7); 1.8186 (1.4); 1.8074 (1.5); 1.8046 (1.7); 1.7940 (2.1); 1.7840 (1.9); 1.7808 (1.6); 1.7746 (1.5); 1.7714 (1.9); 1.7605 (1.7); 1.7510 (1.3); 1.7480 (1.2); 1.7366 (1.1); 0.0080 (1.1); -0.0002 (37.7); -0.0085 (1.1) I.1-190: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9148 (1.0); 7.3566 (1.0); 7.3527 (1.0); 7.3467 (0.5); 7.3368 (0.6); 7.3309 (1.0); 7.3267 (0.9); 7.3105 (0.5); 7.2075 (0.6); 7.2034 (0.6); 7.1947 (0.6); 7.1875 (1.1); 7.1837 (1.1); 7.1747 (1.0); 7.1712 (1.1); 7.1673 (0.7); 7.1632 (0.6); 7.1543 (0.6); 7.1508 (0.6); 7.0711 (1.1); 7.0549 (1.5); 7.0358 (0.7); 4.7323 (1.7); 4.6926 (2.0); 4.2338 (2.2); 4.1940 (1.8); 3.8082 (0.7); 3.7979 (1.0); 3.7878 (1.3); 3.7775 (1.0); 3.7674 (0.7); 3.3174 (82.7); 3.0622 (0.8); 3.0441 (2.6); 3.0303 (2.8); 3.0261 (2.9); 3.0123 (2.7); 3.0082 (1.1); 2.9943 (0.9); 2.5233 (1.0); 2.5186 (1.5); 2.5100 (21.1); 2.5054 (45.2); 2.5008 (62.5); 2.4962 (43.6); 2.4916 (19.9); 2.4772 (1.5); 2.4541 (1.7); 2.4421 (1.9); 2.3815 (0.6); 2.3587 (1.2); 2.3368 (1.2); 2.3167 (1.0); 2.2855 (1.0); 2.2719 (1.2); 2.2614 (1.4); 2.2480 (1.4); 2.2439 (0.6); 2.2195 (0.8); 2.2063 (0.8); 2.1793 (2.0); 2.1581 (1.9); 2.1488 (0.7); 2.1444 (1.7); 2.1295 (1.0); 2.1234 (1.8); 2.1173 (0.7); 2.1102 (0.6); 2.1056 (0.8); 2.0980 (1.1); 2.0934 (0.6); 2.0785 (0.6); 2.0739 (0.8); 1.7541 (0.7); 1.7434 (1.0); 1.7333 (0.8); 1.7221 (0.8); 1.7116 (0.8); 1.7010 (0.5); 0.9946 (7.5); 0.9765 (16.0); 0.9584 (7.2); -0.0002 (1.1) I.1-191: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2662 (0.8); 8.2461 (1.8); 8.2265 (1.0); 7.1440 (1.6); 7.1235 (8.3); 7.1152 (6.2); 7.0936 (1.2); 4.6607 (2.0); 4.6225 (2.2); 4.1993 (0.7); 4.1839 (0.7); 4.0557 (1.0); 4.0208 (1.5); 3.9834 (1.2); 3.6889 (1.0); 3.6794 (0.9); 3.3724 (1.0); 3.3540 (2.0); 3.3215 (663.9); 3.2731 (2.3); 3.1674 (0.9); 2.6746 (1.5); 2.6700 (2.2); 2.6653 (1.6); 2.5608 (1.2); 2.5234 (5.3); 2.5185 (7.8); 2.5100 (134.1); 2.5055 (291.3); 2.5009 (405.4); 2.4963 (285.9); 2.4918 (130.2); 2.4520 (1.4); 2.3736 (0.7); 2.3276 (3.0); 2.3232 (2.2); 2.2760 (16.0); 2.2554 (1.0); 2.2453 (1.1); 2.2310 (1.0); 2.2145 (1.1); 2.1920 (1.0); 2.1757 (0.9); 2.1517 (0.9); 2.1172 (0.8); 1.9985 (0.8); 1.5816 (0.7); 1.5101 (1.3); 1.4974 (1.8); 1.4862 (2.1); 1.4760 (1.3); 1.4628 (1.2); 0.8930 (6.6); 0.8769 (6.3); 0.8283 (5.7); 0.8250 (5.3); 0.8119 (5.8); -0.0002 (14.5) I.1-193: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2624 (10.9); 7.0456 (0.6); 7.0382 (0.8); 7.0354 (0.5); 7.0294 (0.8); 6.3377 (0.8); 6.3324 (0.9); 6.3197 (2.4); 6.3142 (1.3); 5.2992 (0.7); 4.2308 (0.5); 3.7742 (16.0); 2.7484 (0.6); 2.7313 (1.3); 2.7141 (0.6); - 0.0002 (3.1) I.1-194: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4139 (3.9); 7.3961 (10.3); 7.3770 (8.5); 7.3537 (3.3); 7.3337 (6.0); 7.3118 (4.7); 7.2911 (2.0); 7.2186 (11.3); 7.2152 (15.4); 7.1973 (11.5); 7.1268 (2.8); 7.1124 (2.7); 6.9103 (2.5); 4.5334 (2.0); 4.4962 (2.4); 4.1167 (2.4); 4.0751 (2.0); 3.8125 (2.4); 3.3769 (0.8); 3.3285 (209.0); 3.2797 (1.4); 3.2234 (0.6); 3.1689 (2.0); 3.1051 (16.0); 2.6747 (1.1); 2.6701 (1.5); 2.6654 (1.0); 2.6609 (0.6); 2.5401 (0.6); 2.5234 (3.4); 2.5187 (5.2); 2.5101 (89.3); 2.5055 (193.0); 2.5009 (268.9); 2.4963 (187.8); 2.4917 (84.6); 2.4517 (1.4); 2.4294 (1.8); 2.3901 (2.2); 2.3323 (1.4); 2.3277 (1.9); 2.3231 (1.4); 2.2402 (4.0); 2.2191 (4.6); 2.2051 (4.1); 2.1778 (3.2); 2.1425 (2.4); 2.1222 (1.9); 2.1008 (1.9); 2.0718 (2.4); 1.6628 (2.0); -0.0002 (1.3) I.1-195: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8098 (0.8); 7.7906 (0.8); 7.1441 (1.9); 7.1238 (7.4); 7.1094 (8.2); 7.0888 (2.0); 4.6573 (2.0); 4.6194 (2.2); 4.0180 (2.3); 3.9800 (2.0); 3.8206 (0.8); 3.8040 (1.2); 3.7853 (1.2); 3.7689 (0.8); 3.7185 (0.7); 3.7080 (0.9); 3.6973 (1.1); 3.6877 (1.0); 3.6766 (0.7); 3.3845 (24.5); 3.1681 (1.1); 2.6694 (0.7); 2.5229 (1.6); 2.5181 (2.4); 2.5094 (39.5); 2.5049 (85.3); 2.5003 (119.0); 2.4957 (83.1); 2.4911 (37.4); 2.4575 (1.7); 2.4461 (1.8); 2.4232 (1.9); 2.4119 (1.8); 2.3640 (0.5); 2.3411 (1.2); 2.3316 (0.6); 2.3224 (1.5); 2.2995 (1.0); 2.2757 (16.0); 2.2657 (1.4); 2.2517 (1.2); 2.2414 (1.3); 2.2276 (1.3); 2.2100 (0.6); 2.1995 (0.7); 2.1859 (0.6); 2.0826 (1.7); 2.0717 (0.7); 2.0603 (1.8); 2.0483 (1.6); 2.0310 (0.8); 2.0258 (1.8); 2.0198 (0.8); 2.0122 (0.9); 2.0075 (0.6); 1.9929 (0.6); 1.9879 (0.7); 1.7033 (0.6); 1.6917 (0.8); 1.6813 (0.7); 1.6702 (0.7); 1.6598 (0.7); 1.0273 (12.2); 1.0228 (12.3); 1.0109 (12.2); 1.0064 (12.1); 0.0080 (1.0); -0.0002 (33.6); -0.0085 (1.0) I.1-196: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.0772 (0.5); 4.7265 (0.6); 4.6868 (0.7); 4.2454 (0.7); 4.2058 (0.6); 3.3204 (27.1); 3.2966 (1.1); 2.6575 (14.5); 2.5190 (0.6); 2.5104 (9.0); 2.5058 (19.2); 2.5012 (26.3); 2.4965 (18.2); 2.4919 (8.1); 2.3812 (0.7); 2.3693 (0.8); 2.3500 (0.5); 2.3462 (0.8); 2.3341 (1.0); 2.3279 (0.5); 2.2205 (0.5); 1.9824 (0.8); 1.9602 (0.8); 1.9475 (0.7); 1.9252 (0.7); 1.7644 (0.5); 1.7551 (15.5); 1.7540 (16.0); 1.5963 (4.6); -0.0002 (1.0) I.1-197: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5561 (2.6); 8.5420 (4.8); 8.5278 (2.5); 8.2898 (11.9); 8.2884 (12.6); 8.2836 (12.5); 8.2821 (12.1); 7.7063 (8.7); 7.7000 (8.5); 7.6858 (10.7); 7.6795 (10.3); 7.4756 (15.5); 7.4552 (12.9); 7.3763 (1.7); 7.3727 (1.8); 7.3523 (4.0); 7.3361 (2.5); 7.3303 (4.0); 7.3098 (2.2); 7.3058 (2.0); 7.2025 (2.3); 7.1985 (2.4); 7.1896 (2.4); 7.1859 (2.9); 7.1824 (4.2); 7.1788 (4.6); 7.1698 (4.1); 7.1662 (4.6); 7.1622 (2.9); 7.1582 (2.8); 7.1493 (2.3); 7.1457 (2.5); 7.0695 (4.3); 7.0535 (5.9); 7.0501 (5.6); 7.0340 (3.1); 4.7262 (6.7); 4.6866 (7.8); 4.3084 (1.5); 4.2934 (1.5); 4.2700 (8.9); 4.2560 (16.0); 4.2423 (9.1); 4.2239 (8.6); 4.2042 (1.7); 4.1842 (7.3); 3.8354 (1.3); 3.8244 (2.8); 3.8139 (4.0); 3.8037 (4.7); 3.7936 (4.0); 3.7831 (2.9); 3.7724 (1.5); 3.3271 (164.8); 3.2779 (1.3); 3.1689 (0.7); 2.6747 (1.3); 2.6699 (1.8); 2.6654 (1.3); 2.6073 (5.9); 2.5962 (6.0); 2.5719 (7.1); 2.5608 (7.0); 2.5403 (1.1); 2.5235 (4.1); 2.5188 (6.0); 2.5102 (102.8); 2.5056 (226.1); 2.5009 (318.5); 2.4963 (221.4); 2.4917 (98.4); 2.4557 (1.5); 2.4513 (1.9); 2.4469 (1.5); 2.3916 (1.5); 2.3725 (2.0); 2.3684 (2.0); 2.3494 (4.9); 2.3276 (5.9); 2.3072 (4.0); 2.2818 (9.3); 2.2697 (5.1); 2.2594 (12.5); 2.2459 (11.4); 2.2243 (6.1); 2.2172 (3.2); 2.2041 (3.0); 2.1497 (2.0); 2.1303 (3.5); 2.1259 (2.0); 2.1181 (2.6); 2.1110 (2.1); 2.1064 (3.0); 2.0989 (4.1); 2.0942 (2.5); 2.0872 (1.6); 2.0794 (2.4); 2.0748 (3.1); 2.0628 (0.7); 2.0556 (1.3); 1.7673 (1.7); 1.7546 (2.5); 1.7435 (3.5); 1.7332 (2.9); 1.7224 (2.8); 1.7118 (3.1); 1.7011 (1.9); 1.6876 (1.3); 0.0080 (1.1); -0.0002 (35.2); -0.0085 (0.9) I.1-198: 1H-NMR (400.1 MHz, CDCl3): δ= 7.2684 (2.9); 7.2646 (15.8); 7.2627 (16.8); 7.2550 (1.2); 7.1357 (0.6); 7.1152 (1.4); 7.1057 (0.9); 7.1001 (0.9); 7.0941 (1.2); 7.0895 (1.7); 7.0803 (1.2); 7.0710 (1.2); 7.0595 (0.7); 7.0547 (0.7); 6.9907 (0.9); 6.9853 (1.0); 6.9804 (0.9); 6.9701 (0.7); 6.9646 (0.7); 6.0680 (0.8); 4.6967 (1.7); 4.6585 (2.0); 4.1544 (2.0); 4.1161 (1.8); 4.0200 (0.6); 4.0120 (0.8); 4.0004 (1.2); 3.9884 (0.8); 3.9807 (0.7); 3.9689 (0.3); 3.7045 (16.0); 3.5159 (0.6); 3.5021 (1.7); 3.4875 (2.7); 3.4794 (1.1); 3.4731 (1.7); 3.4595 (0.7); 2.5553 (0.4); 2.5299 (2.7); 2.5127 (3.8); 2.5004 (2.6); 2.4912 (2.4); 2.4779 (1.4); 2.4700 (1.1); 2.4542 (1.6); 2.4487 (1.2); 2.4414 (1.6); 2.4347 (1.0); 2.4248 (1.0); 2.4106 (1.1); 2.3917 (0.3); 2.3818 (0.5); 2.3679 (0.5); 2.2943 (0.4); 2.2751 (0.7); 2.2616 (0.6); 2.2552 (0.5); 2.2511 (0.6); 2.2427 (0.9); 2.2323 (0.4); 2.2227 (0.5); 2.2188 (0.6); 2.1624 (1.4); 2.1426 (1.4); 2.1259 (1.2); 2.1060 (1.1); 1.9301 (1.0); 1.8053 (0.4); 1.7932 (0.6); 1.7813 (0.8); 1.7719 (0.8); 1.7602 (0.7); 1.7581 (0.7); 1.7487 (0.6); 1.7372 (0.5); 0.0057 (0.7); 0.0019 (4.1) I.1-199: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5218 (1.1); 7.2628 (208.2); 7.1612 (2.9); 7.1452 (3.6); 7.1407 (6.8); 7.1249 (8.2); 7.1195 (4.4); 7.1147 (2.7); 7.1111 (2.1); 7.1077 (1.9); 7.1010 (6.4); 7.0917 (2.5); 7.0886 (3.3); 7.0846 (3.8); 7.0821 (4.2); 7.0752 (6.9); 7.0686 (2.1); 7.0636 (3.0); 7.0558 (13.8); 7.0491 (12.1); 7.0455 (9.5); 7.0410 (17.0); 7.0324 (7.1); 7.0303 (6.2); 7.0206 (1.2); 7.0134 (1.0); 6.9988 (1.2); 6.8491 (3.0); 6.8467 (2.8); 6.8426 (3.6); 6.8403 (3.9); 6.8283 (4.8); 6.8266 (4.6); 6.8199 (8.8); 6.8162 (5.9); 6.8080 (3.3); 6.7994 (4.8); 6.7938 (6.2); 6.7916 (6.3); 6.7884 (3.5); 6.7851 (4.2); 6.7693 (5.1); 6.7629 (3.8); 5.5040 (3.2); 5.2997 (3.6); 4.8528 (6.6); 4.8491 (6.6); 4.8141 (7.5); 4.8104 (7.4); 4.2353 (9.8); 4.1966 (8.8); 3.9365 (1.6); 3.9254 (3.3); 3.9145 (4.1); 3.9036 (4.3); 3.8943 (4.1); 3.8834 (3.4); 3.8725 (1.6); 3.5086 (0.8); 3.4922 (3.7); 3.4841 (3.4); 3.4747 (8.1); 3.4674 (8.1); 3.4594 (7.8); 3.4518 (8.5); 3.4421 (3.6); 3.4350 (3.9); 3.4174 (0.9); 2.8232 (8.3); 2.8060 (16.0); 2.7888 (7.5); 2.5970 (6.9); 2.5862 (6.9); 2.5608 (8.1); 2.5500 (7.9); 2.5223 (1.4); 2.5037 (1.9); 2.5002 (1.8); 2.4800 (5.0); 2.4607 (4.5); 2.4573 (4.3); 2.4374 (4.2); 2.4229 (5.0); 2.4084 (5.8); 2.3988 (6.9); 2.3844 (6.9); 2.3801 (2.5); 2.3655 (2.0); 2.3558 (3.1); 2.3415 (3.1); 2.2723 (2.7); 2.2531 (4.2); 2.2484 (2.4); 2.2396 (3.2); 2.2341 (2.7); 2.2290 (3.5); 2.2206 (4.7); 2.2155 (2.9); 2.2102 (2.0); 2.2014 (2.8); 2.1962 (3.7); 2.1773 (2.1); 2.1379 (9.3); 2.1154 (9.0); 2.1017 (8.0); 2.0792 (7.9); 1.8279 (2.3); 1.8166 (2.5); 1.8139 (2.9); 1.8031 (3.4); 1.7933 (3.2); 1.7900 (2.7); 1.7839 (2.5); 1.7807 (3.1); 1.7697 (2.8); 1.7603 (2.2); 1.7572 (2.0); 1.7458 (1.8); 0.0079 (1.8); -0.0002 (56.9); -0.0085 (1.6) I.1-200: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1451 (2.0); 7.1250 (6.6); 7.1072 (7.4); 7.1019 (1.5); 7.0867 (2.2); 5.0355 (0.8); 5.0258 (1.0); 5.0192 (1.4); 5.0125 (0.7); 5.0043 (0.8); 4.6507 (1.9); 4.6125 (2.1); 4.0474 (2.2); 4.0092 (1.9); 3.7079 (0.7); 3.6975 (1.1); 3.6872 (1.2); 3.6770 (1.1); 3.6667 (0.7); 3.4267 (17.1); 2.6885 (1.6); 2.6784 (1.7); 2.6493 (2.1); 2.6392 (2.0); 2.5250 (0.6); 2.5202 (0.9); 2.5115 (13.2); 2.5070 (27.9); 2.5024 (37.6); 2.4978 (26.1); 2.4932 (11.7); 2.4055 (0.6); 2.4009 (2.6); 2.3797 (2.6); 2.3618 (2.2); 2.3403 (2.5); 2.2886 (1.0); 2.2749 (16.0); 2.2641 (1.6); 2.2499 (1.3); 2.2221 (0.8); 2.2084 (0.8); 2.1425 (0.6); 2.1304 (0.6); 2.1245 (0.5); 2.1177 (0.6); 2.1125 (0.8); 2.1058 (0.6); 2.0926 (0.6); 2.0861 (0.6); 1.8005 (0.6); 1.7951 (0.6); 1.7864 (1.2); 1.7684 (1.2); 1.7622 (0.8); 1.7564 (0.9); 1.7495 (0.6); 1.7177 (0.5); 1.7044 (0.6); 1.6932 (0.9); 1.6859 (0.6); 1.6823 (0.7); 1.6725 (0.7); 1.6685 (0.5); 1.6611 (0.8); 1.6502 (0.6); 1.6153 (0.6); 1.6025 (1.0); 1.5966 (1.2); 1.5887 (1.0); 1.5839 (1.1); 1.5733 (1.4); 1.5608 (1.5); 1.5521 (2.0); 1.5463 (2.3); 1.5415 (2.6); 1.5359 (1.9); 1.5315 (1.9); 1.5266 (2.1); 1.5182 (2.3); 1.5145 (2.3); 1.5066 (1.6); 1.4979 (1.1); -0.0002 (3.5) I.1-202: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8495 (5.3); 7.3770 (3.1); 7.3732 (3.1); 7.3525 (7.5); 7.3309 (7.4); 7.3104 (4.0); 7.3064 (3.8); 7.2066 (4.2); 7.2027 (4.3); 7.1938 (4.3); 7.1866 (7.9); 7.1829 (8.2); 7.1738 (7.6); 7.1702 (8.5); 7.1664 (5.2); 7.1623 (4.8); 7.1535 (4.4); 7.1498 (4.7); 7.0695 (7.8); 7.0534 (10.9); 7.0342 (5.8); 4.7323 (12.7); 4.6930 (14.7); 4.2237 (16.0); 4.1841 (13.9); 3.8104 (2.6); 3.7998 (5.3); 3.7890 (7.3); 3.7790 (9.9); 3.7690 (7.4); 3.7586 (5.8); 3.7477 (2.6); 3.3210 (402.5); 3.1678 (1.1); 2.6741 (2.5); 2.6695 (3.6); 2.6650 (2.4); 2.5411 (80.2); 2.5296 (86.2); 2.5231 (10.4); 2.5183 (12.4); 2.5096 (208.9); 2.5051 (453.5); 2.5005 (641.2); 2.4959 (442.0); 2.4913 (200.8); 2.4649 (13.8); 2.4531 (13.1); 2.3966 (3.4); 2.3776 (4.3); 2.3549 (9.9); 2.3359 (9.2); 2.3320 (10.4); 2.3226 (3.3); 2.3128 (7.4); 2.2815 (7.5); 2.2680 (9.1); 2.2574 (11.2); 2.2441 (10.8); 2.2263 (3.7); 2.2154 (5.8); 2.2024 (5.9); 2.1860 (13.8); 2.1647 (13.5); 2.1509 (11.6); 2.1454 (5.0); 2.1294 (12.4); 2.1138 (5.2); 2.1067 (4.3); 2.1022 (5.9); 2.0945 (8.4); 2.0899 (4.9); 2.0828 (3.0); 2.0750 (4.7); 2.0705 (6.4); 2.0509 (2.8); 1.7555 (3.4); 1.7428 (5.0); 1.7320 (6.9); 1.7215 (5.5); 1.7108 (5.5); 1.7002 (6.1); 1.6896 (3.8); 1.6764 (2.6); 0.0080 (3.7); -0.0002 (124.4); -0.0086 (3.4) I.1-203: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1470 (1.8); 7.1266 (7.0); 7.1130 (7.8); 7.1073 (1.4); 7.0923 (1.9); 5.9126 (0.6); 5.8987 (1.2); 5.8860 (0.8); 5.8726 (1.4); 5.8695 (0.7); 5.8587 (0.7); 5.8557 (1.5); 5.8429 (0.9); 5.8295 (1.5); 5.8157 (0.7); 5.2970 (0.8); 5.2930 (2.3); 5.2888 (2.4); 5.2847 (0.8); 5.2539 (0.7); 5.2498 (2.0); 5.2457 (2.1); 5.2416 (0.7); 5.2203 (0.9); 5.2169 (2.2); 5.2131 (2.0); 5.2097 (0.8); 5.1941 (0.8); 5.1908 (2.0); 5.1869 (1.8); 5.1835 (0.7); 4.6592 (1.9); 4.6210 (2.2); 4.5164 (2.5); 4.5129 (4.3); 4.5093 (2.5); 4.5026 (2.4); 4.4991 (4.1); 4.4956 (2.3); 4.0594 (2.2); 4.0213 (2.0); 3.7317 (0.8); 3.7212 (1.1); 3.7107 (1.2); 3.7003 (1.1); 3.6899 (0.8); 3.5667 (6.1); 2.7983 (1.5); 2.7882 (1.5); 2.7584 (1.9); 2.7484 (1.8); 2.5204 (0.6); 2.5118 (7.8); 2.5073 (16.4); 2.5027 (22.1); 2.4981 (15.3); 2.4935 (6.9); 2.4862 (2.2); 2.4641 (2.0); 2.4463 (2.0); 2.4242 (1.9); 2.4040 (1.1); 2.3859 (0.8); 2.3804 (0.8); 2.3623 (0.8); 2.2892 (1.0); 2.2753 (16.0); 2.2648 (1.6); 2.2511 (1.2); 2.2229 (0.8); 2.2097 (0.8); 2.1511 (0.7); 2.1386 (0.6); 2.1326 (0.5); 2.1262 (0.6); 2.1201 (0.8); 2.1142 (0.6); 2.1006 (0.5); 2.0948 (0.6); 1.7136 (0.6); 1.7024 (0.9); 1.6944 (0.6); 1.6914 (0.7); 1.6820 (0.7); 1.6782 (0.5); 1.6705 (0.8); -0.0002 (3.3) I.1-204: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.6224 (0.5); 7.6098 (4.0); 7.6044 (4.2); 7.4073 (1.9); 7.4018 (1.8); 7.3864 (2.4); 7.3810 (2.4); 7.2661 (3.0); 7.2453 (2.3); 4.6184 (1.7); 4.5776 (2.0); 4.2290 (1.9); 4.1881 (1.6); 4.0262 (0.5); 3.9644 (0.8); 3.8024 (0.9); 3.7917 (1.5); 3.7799 (2.2); 3.7387 (16.0); 3.1685 (10.4); 2.6701 (0.5); 2.5404 (1.4); 2.5304 (1.5); 2.5236 (1.6); 2.5189 (2.3); 2.5102 (30.2); 2.5056 (64.5); 2.5010 (89.1); 2.4963 (62.4); 2.4918 (28.7); 2.3915 (0.9); 2.3730 (0.8); 2.3693 (0.7); 2.3509 (0.6); 2.3278 (0.6); 2.2839 (0.6); 2.2709 (0.7); 2.2597 (1.0); 2.2468 (1.1); 2.2233 (1.4); 2.2184 (0.8); 2.2068 (0.8); 2.2005 (1.5); 2.1858 (1.7); 2.1737 (0.5); 2.1671 (0.5); 2.1628 (1.4); 2.1551 (0.8); 1.7764 (0.6); 1.7651 (0.7); 1.7545 (0.6); 1.7467 (0.7); 1.7343 (0.6); -0.0002 (9.3) I.1-205: 1H-NMR (400.0 MHz, d6-DMSO): δ= 11.7795 (1.4); 7.5926 (1.1); 7.5890 (1.1); 7.5726 (1.3); 7.5689 (1.2); 7.3775 (1.3); 7.3579 (2.5); 7.3381 (1.4); 7.1927 (1.1); 7.1892 (1.1); 7.1733 (1.0); 7.1697 (0.9); 4.6722 (1.1); 4.6304 (1.3); 4.2906 (1.2); 4.2489 (1.0); 3.8733 (0.6); 3.8627 (0.5); 3.3634 (36.0); 3.1854 (16.0); 3.1683 (5.1); 2.7287 (0.7); 2.7183 (0.7); 2.6905 (1.0); 2.6799 (1.0); 2.6697 (0.5); 2.5232 (1.1); 2.5184 (1.7); 2.5099 (27.0); 2.5053 (57.5); 2.5006 (78.5); 2.4960 (54.6); 2.4914 (24.6); 2.4601 (1.0); 2.4382 (1.2); 2.4219 (0.9); 2.4152 (0.7); 2.4002 (0.8); 2.3326 (0.6); 2.3274 (0.6); 2.3220 (0.9); 2.3100 (0.7); 2.2818 (1.0); 2.2727 (0.7); 2.2457 (0.6); - 0.0002 (3.3) I.1-206: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1480 (1.1); 7.1418 (1.1); 7.1276 (4.4); 7.1151 (4.6); 7.0944 (1.0); 7.0860 (1.6); 7.0660 (0.8); 4.7054 (1.0); 4.6673 (1.2); 4.1760 (2.2); 4.0472 (1.2); 4.0338 (6.3); 4.0087 (1.0); 3.9820 (0.5); 3.7219 (0.6); 3.7106 (0.6); 3.7008 (0.5); 3.6718 (7.4); 3.6171 (16.0); 3.3633 (0.9); 3.3152 (206.8); 3.2658 (1.7); 3.1682 (0.8); 2.9415 (15.3); 2.8031 (0.6); 2.7936 (0.7); 2.7656 (5.4); 2.7534 (0.8); 2.6743 (1.0); 2.6695 (1.6); 2.6649 (1.2); 2.6601 (0.6); 2.5500 (0.6); 2.5453 (0.5); 2.5398 (0.8); 2.5230 (3.1); 2.5183 (4.8); 2.5096 (86.8); 2.5050 (193.2); 2.5004 (272.7); 2.4958 (189.3); 2.4912 (84.6); 2.4671 (1.1); 2.4606 (1.6); 2.4552 (1.5); 2.4505 (1.8); 2.4455 (1.7); 2.4208 (0.9); 2.3967 (0.6); 2.3318 (1.4); 2.3273 (1.7); 2.3226 (1.2); 2.3177 (0.7); 2.2750 (10.6); 2.2587 (0.6); 2.2461 (0.6); 2.2346 (0.7); 2.2221 (0.7); 2.0716 (1.1); -0.0002 (16.0) I.1-207: 1H-NMR (400.1 MHz, d6-DMSO): δ= 8.2967 (1.1); 8.2902 (1.2); 8.2747 (1.2); 8.2688 (1.2); 7.3913 (0.4); 7.3861 (0.3); 7.3703 (1.0); 7.3654 (0.9); 7.3499 (1.0); 7.3453 (1.1); 7.3297 (0.4); 7.3246 (0.6); 7.2223 (0.6); 7.2025 (1.2); 7.1900 (1.3); 7.1862 (1.1); 7.1821 (0.9); 7.1697 (0.8); 7.1151 (0.8); 7.1036 (1.1); 7.0988 (1.2); 7.0946 (1.2); 7.0785 (2.0); 7.0588 (2.4); 6.9965 (2.2); 6.9775 (1.5); 6.8658 (1.9); 6.8477 (2.0); 4.8415 (0.8); 4.8195 (1.7); 4.7935 (2.4); 4.7526 (2.1); 4.2962 (1.2); 4.2812 (1.3); 4.2566 (1.1); 4.2410 (1.1); 3.8952 (0.4); 3.8852 (0.7); 3.8750 (1.0); 3.8654 (1.1); 3.8546 (1.0); 3.8454 (0.8); 3.8351 (0.5); 3.3681 (1.0); 3.3188 (110.0); 3.1684 (1.5); 2.9753 (1.1); 2.9560 (1.2); 2.9370 (1.4); 2.9174 (1.3); 2.6740 (0.5); 2.6695 (0.7); 2.6620 (1.0); 2.6512 (0.8); 2.6402 (0.8); 2.6285 (1.6); 2.6172 (1.0); 2.6057 (1.0); 2.5945 (0.9); 2.5547 (0.6); 2.5502 (0.9); 2.5456 (0.8); 2.5397 (0.9); 2.5229 (1.6); 2.5182 (2.3); 2.5097 (37.1); 2.5051 (81.0); 2.5005 (113.2); 2.4960 (84.2); 2.4915 (43.1); 2.4527 (1.1); 2.4481 (0.7); 2.4388 (0.9); 2.4158 (1.5); 2.4095 (1.6); 2.3970 (1.4); 2.3908 (1.1); 2.3778 (1.6); 2.3548 (0.8); 2.3446 (1.2); 2.3360 (0.9); 2.3322 (0.9); 2.3270 (1.2); 2.3229 (2.4); 2.3166 (1.6); 2.3103 (2.0); 2.2985 (1.9); 2.2942 (1.6); 2.2885 (1.4); 2.2823 (1.6); 2.2691 (0.9); 2.2521 (16.0); 2.2295 (1.0); 2.2180 (0.7); 2.2065 (0.8); 2.1985 (0.7); 2.1891 (1.0); 2.1742 (1.2); 2.1657 (1.1); 2.1543 (1.4); 2.1331 (1.1); 2.1139 (0.5); 2.0718 (0.4); 1.9069 (0.4); 1.8954 (0.5); 1.8766 (0.6); 1.8659 (0.7); 1.8553 (0.7); 1.8445 (0.6); 1.8241 (0.4); 1.1273 (6.0); 1.1215 (6.2); 1.1106 (6.2); 1.1048 (6.0) I.1-210: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.4204 (3.6); 7.3992 (7.5); 7.3934 (4.3); 7.3780 (4.5); 7.3722 (7.7); 7.3510 (3.9); 7.2972 (3.4); 7.2920 (3.6); 7.2775 (3.6); 7.2719 (4.3); 7.2684 (4.3); 7.2629 (3.9); 7.2485 (3.4); 7.2435 (3.6); 7.2038 (6.0); 7.0960 (3.9); 7.0902 (4.1); 7.0853 (4.2); 7.0721 (16.0); 6.9406 (6.4); 4.5633 (7.8); 4.5240 (9.6); 4.3451 (0.3); 4.1739 (9.8); 4.1513 (0.4); 4.1347 (8.2); 3.8432 (1.4); 3.8321 (2.9); 3.8214 (4.3); 3.8111 (5.1); 3.8011 (4.5); 3.7907 (3.3); 3.7800 (1.7); 2.8080 (5.0); 2.7975 (5.3); 2.7682 (6.5); 2.7578 (6.5); 2.6695 (0.5); 2.5100 (31.3); 2.5057 (73.6); 2.5011 (108.0); 2.4966 (82.5); 2.4922 (42.2); 2.4658 (7.5); 2.4437 (7.2); 2.4259 (6.3); 2.4167 (3.0); 2.4040 (6.2); 2.3988 (6.3); 2.3801 (4.6); 2.3753 (4.4); 2.3570 (4.0); 2.3326 (0.7); 2.3283 (0.8); 2.3105 (3.3); 2.2970 (3.8); 2.2863 (5.1); 2.2727 (5.3); 2.2558 (1.5); 2.2445 (3.0); 2.2318 (3.3); 2.2103 (2.2); 2.1922 (3.2); 2.1795 (2.6); 2.1734 (2.5); 2.1677 (2.6); 2.1608 (4.0); 2.1493 (1.8); 2.1414 (2.4); 2.1364 (2.8); 2.1174 (1.3); 2.0715 (1.2); 1.7357 (1.5); 1.7241 (2.8); 1.7127 (3.4); 1.7016 (3.3); 1.6924 (3.4); 1.6809 (3.2); 1.6694 (2.3); 1.6566 (1.6); 0.0084 (0.4); 0.0000 (21.2) I.1-211: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2626 (43.0); 7.0969 (1.1); 7.0845 (0.7); 7.0813 (0.7); 7.0783 (0.8); 7.0703 (1.2); 7.0583 (0.6); 7.0541 (1.3); 7.0505 (2.4); 7.0434 (2.9); 7.0403 (1.9); 7.0349 (3.1); 7.0245 (1.4); 6.7513 (3.3); 6.7316 (4.4); 6.6546 (3.1); 6.6508 (3.6); 6.6154 (2.2); 6.6111 (1.9); 6.5958 (1.7); 6.5914 (1.5); 5.9379 (2.2); 5.9339 (16.0); 5.9301 (2.2); 5.4159 (0.7); 5.2995 (3.0); 4.8498 (1.4); 4.8463 (1.3); 4.8111 (1.5); 4.8074 (1.5); 4.2272 (2.0); 4.1885 (1.7); 3.9359 (0.7); 3.9249 (0.8); 3.9146 (0.9); 3.9049 (0.8); 3.8940 (0.7); 3.4826 (0.8); 3.4654 (1.8); 3.4502 (2.8); 3.4350 (1.7); 3.4183 (0.8); 2.7252 (2.4); 2.7080 (4.8); 2.6908 (2.2); 2.5840 (1.4); 2.5730 (1.4); 2.5479 (1.6); 2.5369 (1.6); 2.4781 (1.0); 2.4589 (0.9); 2.4554 (0.8); 2.4358 (0.8); 2.4218 (1.0); 2.4072 (1.2); 2.3977 (1.4); 2.3833 (1.4); 2.3790 (0.5); 2.3547 (0.6); 2.3405 (0.6); 2.2785 (0.6); 2.2594 (0.8); 2.2546 (0.5); 2.2459 (0.6); 2.2404 (0.5); 2.2353 (0.7); 2.2269 (0.9); 2.2219 (0.6); 2.2077 (0.6); 2.2026 (0.7); 2.1274 (1.8); 2.1051 (1.8); 2.0913 (1.6); 2.0691 (1.5); 1.8164 (0.6); 1.8055 (0.7); 1.7958 (0.6); 1.7926 (0.5); 1.7865 (0.5); 1.7834 (0.6); 1.7723 (0.6); -0.0002 (12.1) I.1-212: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1480 (2.0); 7.1277 (7.2); 7.1122 (7.9); 7.1068 (1.5); 7.0916 (2.1); 4.7365 (0.6); 4.7280 (0.6); 4.7208 (1.3); 4.7124 (1.2); 4.7051 (1.3); 4.6967 (1.2); 4.6894 (0.7); 4.6810 (0.6); 4.6688 (1.5); 4.6307 (1.7); 4.0492 (2.3); 4.0111 (2.0); 3.7159 (0.7); 3.7054 (1.0); 3.6952 (1.1); 3.6846 (1.0); 3.6741 (0.7); 3.4042 (86.0); 3.3688 (1.4); 2.7392 (0.9); 2.7321 (1.0); 2.7295 (1.1); 2.7224 (0.9); 2.7002 (1.2); 2.6931 (1.3); 2.6904 (1.3); 2.6835 (1.1); 2.6716 (0.5); 2.5250 (1.4); 2.5203 (1.9); 2.5116 (27.8); 2.5071 (59.4); 2.5025 (81.5); 2.4979 (57.9); 2.4933 (26.4); 2.4090 (1.5); 2.4030 (1.4); 2.3947 (0.9); 2.3870 (1.3); 2.3807 (1.5); 2.3701 (1.6); 2.3641 (1.2); 2.3482 (1.2); 2.3418 (1.0); 2.3292 (0.5); 2.2920 (0.7); 2.2750 (16.0); 2.2533 (1.1); 2.2277 (0.6); 2.2254 (0.5); 2.2137 (0.6); 2.1683 (0.5); 2.1490 (0.7); 2.1367 (0.6); 2.1310 (0.5); 2.1242 (0.6); 2.1175 (0.8); 2.1123 (0.6); 2.0990 (0.5); 2.0928 (0.6); 1.7130 (0.5); 1.7000 (0.8); 1.6887 (0.8); 1.6787 (0.6); 1.6681 (0.8); 1.6565 (0.6); 1.4960 (1.3); 1.4889 (1.8); 1.4796 (1.7); 1.4770 (1.7); 1.4730 (2.0); 1.4703 (2.0); 1.4612 (1.7); 1.4544 (1.9); 1.4427 (0.6); 1.4361 (0.6); 1.1209 (8.4); 1.1172 (7.9); 1.1052 (8.4); 1.1015 (7.8); 0.8241 (5.4); 0.8056 (11.0); 0.7869 (4.8); -0.0002 (9.1) I.1-213: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.7544 (1.1); 7.7339 (1.2); 7.3757 (0.5); 7.3553 (1.2); 7.3338 (1.2); 7.3127 (0.6); 7.2094 (0.6); 7.2062 (0.6); 7.1895 (1.2); 7.1857 (1.2); 7.1735 (1.3); 7.1655 (0.7); 7.1533 (0.7); 7.0772 (1.2); 7.0611 (1.7); 7.0419 (0.9); 4.7378 (1.9); 4.6981 (2.2); 4.2415 (2.3); 4.2015 (1.9); 3.8041 (0.8); 3.7940 (1.1); 3.7838 (1.4); 3.7734 (1.1); 3.7636 (0.8); 3.6535 (0.6); 3.6441 (0.8); 3.6371 (0.8); 3.6238 (0.9); 3.6075 (0.7); 3.3135 (89.5); 3.2626 (0.7); 2.6698 (0.7); 2.5232 (1.8); 2.5185 (2.5); 2.5099 (41.1); 2.5053 (91.2); 2.5007 (127.6); 2.4960 (88.7); 2.4915 (40.6); 2.4804 (1.6); 2.4699 (1.5); 2.4579 (2.5); 2.4509 (1.2); 2.4461 (1.9); 2.4012 (0.5); 2.3799 (0.6); 2.3589 (1.4); 2.3365 (1.5); 2.3274 (0.9); 2.3227 (0.7); 2.3174 (1.3); 2.2917 (0.7); 2.2866 (0.7); 2.2784 (0.8); 2.2733 (0.9); 2.2679 (1.0); 2.2626 (1.0); 2.2544 (1.0); 2.2495 (1.2); 2.2259 (0.5); 2.2206 (0.6); 2.2126 (0.5); 2.1874 (1.3); 2.1837 (1.4); 2.1660 (1.4); 2.1624 (1.4); 2.1530 (1.2); 2.1491 (1.2); 2.1315 (1.2); 2.1274 (1.7); 2.1138 (0.7); 2.1020 (0.9); 2.0945 (1.2); 2.0707 (0.9); 1.7666 (0.5); 1.7585 (0.7); 1.7534 (0.7); 1.7453 (0.8); 1.7270 (0.7); 1.7217 (0.6); 1.3839 (0.8); 1.3651 (2.8); 1.3583 (1.2); 1.3467 (3.4); 1.3400 (1.8); 1.3299 (2.6); 1.3218 (1.3); 1.3116 (0.8); 0.9915 (16.0); 0.9749 (15.7); 0.8150 (4.3); 0.8118 (4.5); 0.7966 (9.0); 0.7934 (9.5); 0.7779 (3.8); 0.7747 (3.8); -0.0002 (12.0) I.1-215: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.7858 (1.4); 7.4255 (0.6); 7.4043 (1.2); 7.3985 (0.6); 7.3832 (0.7); 7.3773 (1.2); 7.3562 (0.6); 7.2958 (0.5); 7.2907 (0.5); 7.2762 (0.5); 7.2708 (0.6); 7.2670 (0.6); 7.2616 (0.6); 7.2471 (0.5); 7.2420 (0.5); 7.0958 (0.6); 7.0915 (0.6); 7.0861 (0.6); 7.0807 (0.6); 7.0752 (0.5); 7.0700 (0.5); 7.0647 (0.5); 4.5877 (1.2); 4.5485 (1.4); 4.1494 (1.5); 4.1102 (1.2); 3.8330 (0.5); 3.8226 (0.6); 3.8123 (0.8); 3.8023 (0.6); 3.7919 (0.5); 3.3743 (0.8); 3.3232 (238.2); 3.2740 (1.2); 3.2174 (16.0); 2.7224 (0.9); 2.7114 (0.9); 2.6839 (1.2); 2.6729 (1.3); 2.6661 (0.4); 2.5238 (1.0); 2.5191 (1.4); 2.5104 (23.6); 2.5059 (51.0); 2.5014 (70.2); 2.4968 (49.8); 2.4924 (23.3); 2.4522 (0.3); 2.4134 (0.4); 2.4084 (0.4); 2.3899 (0.9); 2.3843 (1.2); 2.3714 (0.8); 2.3627 (1.3); 2.3462 (1.3); 2.3328 (0.4); 2.3240 (1.2); 2.3136 (0.6); 2.2999 (0.6); 2.2894 (0.8); 2.2759 (0.8); 2.2476 (0.4); 2.2347 (0.5); 2.2070 (0.3); 2.1883 (0.5); 2.1759 (0.4); 2.1693 (0.3); 2.1642 (0.4); 2.1569 (0.6); 2.1521 (0.4); 2.1374 (0.4); 2.1327 (0.4); 1.7440 (0.4); 1.7323 (0.5); 1.7216 (0.5); 1.7121 (0.5); 1.7006 (0.5); 1.6894 (0.3) I.1-216: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.8459 (3.1); 8.3318 (2.1); 8.3199 (2.3); 8.3119 (2.4); 8.3003 (2.0); 7.5429 (4.2); 7.5234 (4.5); 7.3425 (4.4); 7.3242 (4.7); 7.3223 (5.1); 7.1327 (8.3); 7.1148 (6.8); 7.0912 (8.1); 7.0857 (5.9); 7.0798 (6.5); 7.0708 (5.3); 7.0681 (5.4); 7.0475 (2.8); 7.0446 (2.2); 7.0064 (5.3); 6.9972 (3.9); 6.9945 (3.2); 6.9865 (4.0); 6.9797 (4.2); 6.9774 (4.5); 6.9599 (2.1); 6.9573 (1.6); 4.6282 (2.0); 4.5910 (2.6); 4.5590 (2.0); 4.5299 (0.7); 4.5176 (0.9); 4.5069 (1.6); 4.4945 (1.7); 4.4866 (1.6); 4.4742 (1.6); 4.4633 (0.8); 4.4511 (0.6); 4.0140 (2.3); 3.9760 (2.1); 3.8852 (2.2); 3.8468 (2.1); 3.6247 (2.2); 3.6155 (2.6); 3.6061 (2.6); 3.4574 (1.8); 3.3587 (85.4); 3.1993 (1.8); 3.1872 (1.9); 3.1628 (2.5); 3.1513 (2.2); 3.0152 (1.7); 3.0083 (1.8); 2.9923 (1.8); 2.9850 (2.0); 2.9716 (1.5); 2.9560 (1.4); 2.9487 (1.4); 2.6821 (1.3); 2.6777 (1.2); 2.6125 (1.2); 2.5696 (1.3); 2.5653 (1.3); 2.5607 (1.2); 2.5218 (28.5); 2.5176 (57.4); 2.5131 (77.1); 2.5087 (60.2); 2.4910 (2.6); 2.4852 (2.5); 2.4729 (2.3); 2.4679 (2.6); 2.4569 (2.1); 2.3444 (0.8); 2.3398 (0.9); 2.3355 (0.8); 2.3233 (0.8); 2.3017 (1.5); 2.2754 (16.0); 2.2670 (14.9); 2.2391 (2.2); 2.2173 (1.2); 2.2049 (1.0); 2.1911 (1.3); 2.1863 (1.4); 2.1809 (1.5); 2.1631 (2.8); 2.1484 (1.8); 2.1386 (2.7); 2.1301 (2.0); 2.1154 (1.9); 2.1066 (2.1); 2.0968 (1.2); 2.0809 (1.3); 1.9159 (0.7); 1.9036 (0.6); 1.8926 (0.8); 1.8842 (0.9); 1.8604 (0.8); 1.7975 (0.7); 1.7855 (0.6); 1.7741 (0.8); 1.7661 (0.9); 1.7548 (0.5); 1.7423 (0.8); 1.6739 (0.6); 1.6635 (0.8); 1.6528 (0.8); 1.6410 (0.8); 1.6316 (0.6); 1.4291 (0.6); 1.4184 (0.8); 1.4079 (0.8); 1.3959 (0.8); 1.3863 (0.7) I.1-217: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2307 (0.7); 7.2119 (1.7); 7.1932 (1.1); 7.0820 (0.9); 7.0633 (0.7); 7.0176 (1.5); 6.9864 (0.7); 4.6545 (1.1); 4.6165 (1.2); 4.0623 (1.2); 4.0238 (1.0); 3.7354 (0.6); 3.7251 (0.6); 3.7148 (0.6); 3.5531 (16.0); 3.3851 (15.2); 3.1671 (0.5); 2.7551 (0.8); 2.7448 (0.9); 2.7152 (1.1); 2.7049 (1.0); 2.6787 (0.6); 2.6742 (1.2); 2.6697 (1.7); 2.6651 (1.2); 2.5554 (0.6); 2.5506 (0.8); 2.5459 (0.6); 2.5404 (0.6); 2.5231 (4.7); 2.5184 (7.2); 2.5098 (95.0); 2.5052 (203.8); 2.5006 (283.6); 2.4960 (198.0); 2.4914 (87.9); 2.4599 (1.4); 2.4380 (1.2); 2.4202 (1.1); 2.4050 (0.7); 2.3981 (1.1); 2.3855 (0.5); 2.3625 (0.6); 2.3367 (0.6); 2.3320 (1.3); 2.3274 (1.8); 2.3227 (1.3); 2.3009 (0.6); 2.2845 (8.5); 2.2769 (1.2); 2.2633 (0.8); 2.1330 (0.5); 1.7031 (0.5); 0.0080 (4.1); -0.0002 (142.6); -0.0086 (4.3) I.1-218: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3802 (0.8); 7.3589 (1.0); 7.2565 (0.8); 7.2352 (0.6); 3.5497 (0.5); 3.4606 (16.0); 3.1678 (0.7); 2.5230 (1.1); 2.5182 (1.5); 2.5096 (21.0); 2.5050 (44.9); 2.5003 (61.6); 2.4957 (42.8); 2.4911 (19.2); 2.0719 (0.5); -0.0002 (6.9) I.1-220: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2646 (2.0); 8.2447 (2.0); 7.2287 (1.8); 7.2244 (2.1); 7.2142 (4.7); 7.2107 (6.7); 7.1978 (1.0); 7.1749 (1.1); 7.1689 (1.0); 7.1561 (2.2); 7.1491 (2.0); 7.1421 (1.5); 7.1350 (2.1); 7.1305 (2.8); 7.1274 (3.0); 7.1096 (1.1); 4.7649 (2.4); 4.7258 (2.7); 4.1878 (0.7); 4.1726 (0.9); 4.1677 (1.0); 4.1525 (1.2); 4.1456 (0.8); 4.1303 (0.8); 4.0616 (2.3); 4.0225 (2.1); 3.6751 (0.7); 3.6538 (1.2); 3.6323 (0.8); 3.6231 (0.6); 3.4737 (3.5); 3.1671 (4.5); 2.6753 (0.8); 2.6707 (1.1); 2.6661 (0.8); 2.6280 (1.0); 2.6094 (3.0); 2.6053 (3.0); 2.5904 (3.0); 2.5865 (3.1); 2.5729 (1.9); 2.5680 (1.8); 2.5641 (1.8); 2.5409 (0.8); 2.5282 (1.1); 2.5241 (2.4); 2.5195 (4.0); 2.5107 (60.6); 2.5062 (132.6); 2.5016 (185.3); 2.4970 (131.7); 2.4925 (59.6); 2.4777 (2.1); 2.4730 (2.5); 2.4684 (2.6); 2.4637 (1.8); 2.4519 (1.2); 2.4471 (0.8); 2.4158 (1.0); 2.3957 (0.9); 2.3739 (1.6); 2.3507 (0.8); 2.3330 (0.8); 2.3284 (1.2); 2.3238 (0.8); 2.2908 (0.9); 2.2807 (1.0); 2.2669 (1.2); 2.2565 (1.3); 2.2493 (0.8); 2.2380 (2.1); 2.2249 (0.8); 2.2142 (2.1); 2.2035 (1.4); 2.1796 (1.3); 2.0753 (0.6); 2.0400 (0.7); 2.0312 (0.6); 2.0189 (0.8); 2.0082 (1.0); 1.9876 (0.9); 1.8408 (0.7); 1.8325 (0.6); 1.8276 (0.6); 1.8185 (1.0); 1.8087 (1.0); 1.8000 (0.5); 1.7867 (0.5); 1.6149 (0.6); 1.5949 (0.8); 1.5788 (0.8); 1.5626 (0.6); 1.5055 (1.5); 1.4974 (1.8); 1.4929 (1.5); 1.4825 (2.8); 1.4752 (1.4); 1.4690 (1.4); 1.4610 (1.3); 1.1430 (7.0); 1.1242 (16.0); 1.1053 (6.9); 0.8940 (10.2); 0.8777 (9.9); 0.8258 (10.3); 0.8096 (10.1); 0.0080 (0.7); -0.0002 (24.4); -0.0086 (0.8) I.1-222: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8299 (5.8); 7.2391 (0.9); 7.2204 (2.2); 7.2016 (1.4); 7.0863 (1.5); 7.0669 (1.2); 7.0496 (2.0); 7.0377 (1.4); 7.0169 (1.4); 4.7144 (1.2); 4.6758 (1.3); 4.0840 (1.4); 4.0455 (1.3); 3.8412 (0.6); 3.8307 (0.7); 3.8190 (0.8); 3.8091 (0.7); 3.7989 (0.6); 3.5921 (16.0); 2.8641 (0.5); 2.8543 (0.5); 2.8273 (0.7); 2.8175 (0.6); 2.7662 (2.0); 2.7539 (2.0); 2.5236 (0.5); 2.5189 (0.9); 2.5102 (17.6); 2.5057 (38.7); 2.5011 (54.4); 2.4965 (39.0); 2.4919 (18.3); 2.4683 (1.0); 2.4647 (1.0); 2.4512 (0.5); 2.4433 (1.0); 2.4210 (0.9); 2.4020 (0.8); 2.3978 (0.8); 2.3790 (0.7); 2.3325 (0.8); 2.3280 (0.5); 2.3190 (0.8); 2.3082 (0.9); 2.2875 (12.1); 2.2664 (0.6); 2.2534 (0.6); 2.1821 (0.6); 2.1580 (0.6); 2.1509 (0.7); 2.1458 (0.5); 2.1264 (0.6); 2.0732 (1.3); 1.8203 (0.6); 1.8104 (0.5); 1.7996 (0.6); 1.7887 (0.6); 1.7778 (0.5); 1.0710 (0.8); 1.0530 (1.7); 1.0350 (0.7); 0.0080 (0.5); -0.0002 (17.6); -0.0085 (0.6) I.1-225: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.7955 (4.3); 8.0700 (2.2); 8.0560 (4.4); 8.0419 (2.1); 7.5174 (6.1); 7.4975 (6.5); 7.3808 (1.2); 7.3768 (1.3); 7.3603 (2.6); 7.3563 (2.9); 7.3502 (1.7); 7.3358 (10.9); 7.3338 (8.2); 7.3179 (6.5); 7.3157 (10.7); 7.3135 (7.3); 7.2085 (1.5); 7.2046 (1.7); 7.1958 (1.7); 7.1918 (2.0); 7.1885 (2.9); 7.1849 (3.1); 7.1757 (2.8); 7.1724 (3.2); 7.1683 (2.0); 7.1644 (1.9); 7.1555 (1.6); 7.1519 (1.7); 7.1238 (9.0); 7.1181 (8.7); 7.0747 (5.0); 7.0718 (6.0); 7.0571 (7.9); 7.0545 (11.1); 7.0519 (7.4); 7.0371 (6.2); 7.0343 (6.2); 6.9827 (5.5); 6.9800 (5.8); 6.9651 (5.0); 6.9628 (8.4); 6.9604 (6.2); 6.9455 (3.9); 6.9429 (3.7); 4.7400 (4.5); 4.7002 (5.2); 4.2323 (5.6); 4.1926 (4.9); 3.8159 (0.9); 3.8051 (1.8); 3.7946 (2.6); 3.7845 (3.3); 3.7745 (2.6); 3.7641 (1.8); 3.7534 (0.9); 3.4882 (16.0); 3.3360 (2.3); 3.3204 (5.3); 3.3028 (5.5); 3.2865 (2.8); 3.1700 (0.5); 2.8030 (5.9); 2.7837 (8.9); 2.7663 (5.1); 2.6704 (0.5); 2.5405 (0.6); 2.5190 (5.3); 2.5104 (30.4); 2.5059 (66.3); 2.5012 (90.3); 2.4966 (62.8); 2.4920 (28.2); 2.4843 (5.1); 2.4726 (4.3); 2.3874 (1.0); 2.3675 (1.5); 2.3644 (1.5); 2.3450 (3.2); 2.3256 (3.2); 2.3028 (2.5); 2.2718 (2.4); 2.2584 (2.9); 2.2477 (3.6); 2.2344 (3.5); 2.2166 (1.4); 2.2058 (2.1); 2.1980 (4.8); 2.1928 (2.4); 2.1765 (4.4); 2.1631 (3.8); 2.1416 (3.7); 2.1179 (1.2); 2.0984 (2.2); 2.0941 (1.4); 2.0862 (1.7); 2.0791 (1.5); 2.0744 (2.2); 2.0668 (2.7); 2.0623 (1.7); 2.0551 (1.0); 2.0472 (1.5); 2.0428 (2.1); 2.0232 (0.9); 1.7426 (1.2); 1.7299 (1.7); 1.7191 (2.4); 1.7089 (2.1); 1.6975 (2.1); 1.6872 (2.1); 1.6767 (1.2); 1.6636 (0.9); -0.0002 (8.2) I.1-226: 1H-NMR (400.1 MHz, d6-DMSO): δ= 12.3354 (1.1); 7.6245 (15.2); 7.6192 (16.0); 7.4172 (6.9); 7.4119 (6.6); 7.3964 (9.3); 7.3911 (9.1); 7.2838 (13.5); 7.2629 (10.0); 4.6530 (8.3); 4.6123 (10.0); 4.2473 (9.3); 4.2065 (7.8); 3.8069 (1.2); 3.7965 (2.4); 3.7861 (3.7); 3.7762 (4.2); 3.7658 (3.8); 3.7554 (3.0); 3.7449 (1.1); 3.3368 (8.3); 2.6737 (0.3); 2.6690 (0.4); 2.6569 (5.2); 2.6465 (5.3); 2.6170 (7.0); 2.6067 (6.7); 2.5393 (0.4); 2.5224 (0.9); 2.5091 (19.8); 2.5047 (41.9); 2.5002 (58.2); 2.4957 (42.5); 2.4912 (20.6); 2.4688 (1.8); 2.4512 (1.9); 2.4410 (1.2); 2.4276 (4.6); 2.4115 (9.9); 2.4046 (3.8); 2.3899 (8.3); 2.3719 (5.8); 2.3500 (5.3); 2.3315 (0.4); 2.3270 (0.5); 2.3135 (2.5); 2.3011 (2.6); 2.2891 (4.5); 2.2768 (4.7); 2.2486 (8.4); 2.2391 (5.2); 2.2303 (2.8); 2.2247 (2.2); 2.2194 (1.2); 2.2123 (3.6); 2.2063 (1.6); 2.2003 (1.1); 2.1931 (2.0); 2.1876 (2.0); 2.1688 (1.0); 1.8062 (0.9); 1.7824 (3.3); 1.7715 (2.9); 1.7611 (3.2); 1.7536 (2.0); 1.7482 (2.0); 1.7447 (2.0); 1.7403 (2.2); 1.7290 (2.2); 1.7171 (1.2); 1.3514 (0.4); 1.2279 (0.4) I.1-227: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1473 (2.0); 7.1271 (7.0); 7.1106 (7.6); 7.0901 (2.1); 4.7989 (0.7); 4.7851 (0.9); 4.7719 (0.7); 4.7664 (0.5); 4.6675 (1.9); 4.6293 (2.1); 4.0466 (1.9); 4.0084 (1.7); 3.7115 (0.6); 3.7012 (0.8); 3.6906 (1.0); 3.6801 (0.8); 3.6698 (0.6); 3.3933 (63.2); 2.7348 (0.8); 2.7251 (1.6); 2.7156 (0.8); 2.6957 (1.1); 2.6861 (1.9); 2.6766 (1.2); 2.5251 (0.8); 2.5204 (1.1); 2.5117 (18.1); 2.5072 (38.7); 2.5026 (53.0); 2.4980 (37.8); 2.4935 (17.4); 2.4002 (1.2); 2.3932 (1.8); 2.3782 (1.5); 2.3712 (1.9); 2.3614 (1.0); 2.3541 (1.4); 2.3393 (1.0); 2.3320 (1.0); 2.2918 (0.7); 2.2757 (16.0); 2.2531 (1.1); 2.2277 (0.5); 2.2134 (0.5); 2.1460 (0.6); 2.1216 (0.5); 2.1144 (0.8); 2.0898 (0.5); 1.6948 (0.5); 1.6787 (0.6); 1.6710 (0.5); 1.6631 (0.6); 1.4761 (0.5); 1.4681 (0.5); 1.4584 (0.8); 1.4519 (0.7); 1.4436 (1.2); 1.4374 (0.6); 1.4340 (0.6); 1.4257 (1.1); 1.4192 (1.0); 1.4141 (0.6); 1.4109 (0.7); 1.4056 (1.0); 1.3918 (0.7); 1.3899 (0.7); 1.2766 (0.7); 1.2560 (1.2); 1.2377 (1.4); 1.2315 (0.7); 1.2208 (1.0); 1.2135 (0.7); 1.2040 (0.5); 1.1968 (0.6); 1.1231 (7.7); 1.1206 (7.7); 1.1075 (7.7); 1.1049 (7.6); 0.8620 (4.9); 0.8433 (9.4); 0.8253 (4.1); -0.0002 (9.6) I.1-228: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1395 (2.1); 7.1193 (7.0); 7.1024 (7.8); 7.0819 (2.2); 4.6163 (2.0); 4.5785 (2.3); 4.0917 (2.2); 4.0538 (2.0); 3.7972 (0.7); 3.7867 (0.9); 3.7765 (1.1); 3.7666 (0.9); 3.7561 (0.7); 3.4312 (20.4); 3.3139 (0.6); 3.2974 (1.1); 3.2890 (0.9); 3.2801 (0.8); 3.2724 (1.6); 3.2551 (0.9); 3.2260 (1.8); 3.2092 (3.4); 3.1923 (1.7); 3.1714 (0.8); 3.1687 (0.9); 3.1548 (1.4); 3.1467 (0.6); 3.1381 (0.9); 3.1296 (1.0); 3.1129 (0.6); 2.6413 (1.1); 2.6305 (1.1); 2.6012 (1.4); 2.5904 (1.3); 2.5234 (0.7); 2.5186 (0.9); 2.5099 (18.2); 2.5054 (40.5); 2.5008 (57.2); 2.4962 (40.4); 2.4916 (18.5); 2.4228 (0.6); 2.4181 (0.6); 2.3998 (1.2); 2.3810 (0.9); 2.3766 (0.8); 2.3582 (0.8); 2.3278 (1.7); 2.3061 (1.4); 2.2879 (1.3); 2.2729 (16.0); 2.2498 (1.0); 2.2390 (1.3); 2.2254 (1.3); 2.2084 (0.5); 2.1973 (0.8); 2.1842 (0.8); 2.1235 (0.8); 2.1110 (0.6); 2.1050 (0.5); 2.0993 (0.6); 2.0922 (0.9); 2.0869 (0.5); 2.0719 (0.8); 2.0676 (0.7); 1.8212 (0.8); 1.8102 (1.2); 1.8047 (1.4); 1.7943 (1.6); 1.7868 (1.2); 1.7785 (1.3); 1.7627 (0.7); 1.7448 (1.1); 1.7287 (2.7); 1.7123 (2.9); 1.6953 (1.5); 1.6830 (0.6); 1.6716 (0.7); 1.6600 (0.8); 1.6484 (0.7); 1.6398 (0.7); 1.6281 (0.7); 1.6162 (0.5) I.1-230: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9121 (1.0); 7.3525 (1.0); 7.3309 (1.0); 7.3270 (0.9); 7.3107 (0.5); 7.3069 (0.5); 7.2071 (0.6); 7.2031 (0.6); 7.1945 (0.6); 7.1904 (0.7); 7.1872 (1.1); 7.1833 (1.2); 7.1744 (1.0); 7.1708 (1.2); 7.1668 (0.7); 7.1627 (0.7); 7.1540 (0.6); 7.1503 (0.6); 7.0730 (1.1); 7.0570 (1.5); 7.0376 (0.8); 4.7349 (1.7); 4.6950 (2.0); 4.2353 (2.1); 4.1954 (1.8); 3.8054 (0.7); 3.7953 (0.9); 3.7849 (1.3); 3.7747 (1.0); 3.7645 (0.7); 3.3070 (72.1); 3.2566 (0.6); 3.1685 (0.5); 2.9992 (1.0); 2.9817 (2.1); 2.9677 (2.2); 2.9560 (2.0); 2.9386 (1.0); 2.6695 (0.6); 2.5229 (1.7); 2.5182 (2.4); 2.5095 (38.6); 2.5050 (84.7); 2.5003 (118.4); 2.4957 (83.3); 2.4911 (36.6); 2.4723 (2.1); 2.4604 (2.2); 2.4552 (0.8); 2.4505 (0.9); 2.4459 (0.6); 2.3803 (0.6); 2.3578 (1.2); 2.3361 (1.3); 2.3271 (0.8); 2.3224 (0.6); 2.3161 (1.1); 2.2858 (1.0); 2.2723 (1.2); 2.2617 (1.5); 2.2483 (1.5); 2.2305 (0.5); 2.2198 (0.8); 2.2066 (0.8); 2.1970 (1.9); 2.1758 (1.8); 2.1622 (1.6); 2.1465 (0.7); 2.1409 (1.6); 2.1272 (1.0); 2.1227 (0.6); 2.1149 (0.7); 2.1079 (0.6); 2.1032 (0.8); 2.0956 (1.1); 2.0910 (0.7); 2.0763 (0.6); 2.0714 (1.3); 1.7588 (0.7); 1.7478 (0.9); 1.7378 (0.7); 1.7268 (0.7); 1.7160 (0.8); 1.3962 (2.0); 1.3781 (4.1); 1.3600 (4.5); 1.3420 (2.4); 1.3239 (0.5); 0.8362 (7.6); 0.8178 (16.0); 0.7991 (6.7); -0.0002 (9.2) I.1-231: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.1977 (1.4); 7.1491 (1.9); 7.1288 (7.5); 7.1153 (8.3); 7.0946 (2.1); 7.0660 (3.0); 6.9343 (1.6); 4.6390 (2.1); 4.6008 (2.3); 4.0280 (2.4); 3.9898 (2.2); 3.7637 (0.4); 3.7536 (0.8); 3.7429 (1.0); 3.7320 (1.2); 3.7218 (1.1); 3.7115 (0.8); 3.7012 (0.4); 2.8114 (1.3); 2.8013 (1.4); 2.7721 (1.6); 2.7620 (1.6); 2.5181 (0.4); 2.5094 (9.3); 2.5049 (21.4); 2.5002 (30.9); 2.4956 (23.0); 2.4911 (11.3); 2.4443 (1.5); 2.4312 (0.6); 2.4219 (1.6); 2.4053 (1.7); 2.3885 (1.3); 2.3828 (1.5); 2.3697 (1.0); 2.3662 (1.0); 2.3466 (0.8); 2.2778 (16.0); 2.2615 (1.4); 2.2484 (1.2); 2.2444 (0.7); 2.2311 (0.5); 2.2195 (0.7); 2.2068 (0.7); 2.1524 (0.4); 2.1330 (0.8); 2.1285 (0.5); 2.1204 (0.6); 2.1138 (0.6); 2.1087 (0.7); 2.1013 (0.9); 2.0966 (0.6); 2.0897 (0.4); 2.0817 (0.5); 2.0769 (0.7); 1.7193 (0.4); 1.7072 (0.6); 1.6960 (0.8); 1.6855 (0.8); 1.6748 (0.8); 1.6641 (0.8); 1.6527 (0.5); 1.6404 (0.3) I.1-233: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.5146 (0.9); 7.3755 (0.8); 7.3571 (1.0); 7.3503 (0.4); 7.3458 (0.8); 7.3416 (0.6); 7.2944 (0.9); 7.2018 (0.6); 7.1838 (0.5); 4.6606 (0.6); 4.6216 (0.6); 4.1332 (0.6); 4.0941 (0.6); 3.3344 (37.3); 2.7738 (16.0); 2.7385 (0.4); 2.7282 (0.4); 2.7009 (0.5); 2.6906 (0.4); 2.5113 (4.0); 2.5068 (8.8); 2.5023 (12.3); 2.4977 (8.9); 2.4932 (4.2); 2.3972 (0.3); 2.3782 (0.3); 2.3718 (0.6); 2.3492 (0.5); 2.3339 (0.4); 2.3111 (0.5); 2.2985 (0.4); 2.2851 (0.3) I.1-235: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.7425 (0.7); 7.7236 (0.7); 7.1456 (1.4); 7.1251 (6.3); 7.1136 (7.1); 7.1077 (1.1); 7.0928 (1.5); 4.6667 (0.9); 4.6611 (0.9); 4.6289 (1.0); 4.6232 (1.0); 4.0300 (1.0); 4.0218 (1.0); 3.9919 (0.9); 3.9835 (0.9); 3.7081 (0.6); 3.6967 (0.7); 3.6855 (0.6); 3.6743 (0.6); 3.6475 (0.5); 3.6401 (0.5); 3.6309 (0.6); 3.6274 (0.6); 3.4529 (16.0); 2.5233 (0.6); 2.5186 (0.8); 2.5100 (13.0); 2.5054 (28.1); 2.5008 (39.0); 2.4962 (27.1); 2.4916 (12.3); 2.4821 (1.4); 2.4707 (0.7); 2.4593 (0.8); 2.4480 (1.4); 2.4367 (0.7); 2.3447 (0.9); 2.3264 (0.9); 2.3228 (0.9); 2.3026 (0.7); 2.2760 (13.0); 2.2588 (0.6); 2.2531 (0.6); 2.2488 (0.6); 2.2428 (0.6); 2.2347 (0.6); 2.2293 (0.6); 2.1058 (1.2); 2.0832 (1.2); 2.0716 (1.1); 2.0491 (1.1); 2.0120 (0.6); 1.3693 (1.4); 1.3583 (0.8); 1.3510 (2.1); 1.3401 (1.1); 1.3334 (1.6); 1.3219 (0.7); 0.9965 (5.6); 0.9935 (5.7); 0.9799 (5.6); 0.9770 (5.6); 0.8170 (2.6); 0.8128 (2.6); 0.7986 (5.4); 0.7944 (5.4); 0.7799 (2.3); 0.7758 (2.2) I.1-237: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2613 (34.4); 7.2290 (0.9); 7.2241 (0.6); 7.2157 (0.6); 7.2136 (0.6); 7.2087 (1.0); 7.2038 (0.6); 7.1954 (0.5); 7.1906 (0.6); 7.1692 (0.5); 7.1648 (0.6); 7.1505 (1.3); 7.1460 (1.3); 7.1316 (1.1); 7.1271 (0.9); 7.1122 (27.7); 7.0931 (1.8); 7.0900 (1.9); 7.0745 (1.8); 7.0715 (2.0); 7.0559 (0.7); 7.0529 (0.8); 7.0469 (1.0); 7.0442 (0.9); 7.0264 (0.8); 7.0220 (1.2); 7.0188 (1.0); 7.0010 (0.8); 6.9979 (0.8); 5.3879 (0.6); 5.2980 (0.5); 4.7028 (1.8); 4.6652 (2.0); 4.1193 (1.8); 4.0817 (1.6); 3.9358 (0.6); 3.9252 (0.8); 3.9150 (1.0); 3.9050 (0.8); 3.8944 (0.7); 3.5006 (0.8); 3.4833 (1.2); 3.4676 (1.1); 3.4609 (0.5); 3.4505 (0.6); 3.4438 (1.0); 3.4287 (1.1); 3.4116 (0.7); 2.8288 (1.5); 2.8117 (3.0); 2.7946 (1.4); 2.4989 (1.3); 2.4876 (1.5); 2.4693 (1.0); 2.4629 (1.5); 2.4514 (2.2); 2.4276 (0.8); 2.4127 (0.9); 2.3984 (1.0); 2.3884 (1.2); 2.3743 (1.2); 2.3700 (0.5); 2.3456 (0.6); 2.3315 (0.7); 2.3216 (16.0); 2.1912 (0.7); 2.1779 (0.5); 2.1670 (0.7); 2.1587 (0.8); 2.1538 (0.5); 2.1342 (0.7); 2.0678 (1.5); 2.0462 (1.5); 2.0317 (1.3); 2.0101 (1.3); 1.7343 (0.6); 1.7243 (0.6); 1.7115 (0.6); 1.7010 (0.5); -0.0002 (10.3) I.1-238: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5217 (1.2); 7.2627 (223.6); 7.2269 (2.2); 7.2106 (4.4); 7.2059 (3.8); 7.1942 (2.5); 7.1896 (8.4); 7.1850 (3.1); 7.1733 (3.8); 7.1687 (5.2); 7.1524 (2.5); 7.1168 (1.4); 7.1063 (2.2); 7.1022 (1.8); 7.0921 (5.0); 7.0800 (3.3); 7.0762 (3.6); 7.0735 (4.0); 7.0675 (7.0); 7.0601 (2.2); 7.0558 (3.2); 7.0486 (14.2); 7.0419 (12.2); 7.0380 (9.2); 7.0334 (16.0); 7.0250 (6.8); 7.0226 (5.7); 7.0129 (1.2); 7.0059 (1.1); 6.9987 (1.2); 6.9030 (1.2); 6.8986 (1.6); 6.8870 (10.5); 6.8780 (1.9); 6.8674 (14.1); 6.8566 (2.0); 6.8472 (9.2); 6.8352 (1.3); 6.8316 (1.0); 5.5095 (2.9); 5.2996 (0.8); 4.8468 (6.2); 4.8432 (6.2); 4.8080 (7.0); 4.8044 (7.0); 4.2270 (9.2); 4.1882 (8.1); 3.9262 (1.5); 3.9153 (3.1); 3.9041 (3.6); 3.8956 (3.8); 3.8926 (3.8); 3.8840 (3.6); 3.8727 (3.2); 3.8619 (1.5); 3.5525 (0.6); 3.5360 (1.6); 3.5189 (3.4); 3.5022 (7.1); 3.4859 (8.0); 3.4828 (8.0); 3.4669 (7.5); 3.4505 (3.3); 3.4330 (1.7); 3.4173 (0.6); 2.9016 (7.7); 2.8853 (14.6); 2.8689 (6.8); 2.5965 (6.4); 2.5860 (6.4); 2.5603 (7.4); 2.5498 (7.3); 2.5154 (1.3); 2.4954 (1.8); 2.4919 (1.7); 2.4716 (4.7); 2.4523 (4.2); 2.4490 (4.0); 2.4301 (3.9); 2.4118 (4.6); 2.3972 (5.4); 2.3876 (6.3); 2.3732 (6.4); 2.3689 (2.5); 2.3543 (2.0); 2.3446 (2.9); 2.3303 (2.9); 2.2516 (2.4); 2.2325 (3.8); 2.2276 (2.3); 2.2187 (2.9); 2.2135 (2.4); 2.2083 (3.2); 2.1998 (4.3); 2.1946 (2.8); 2.1895 (1.9); 2.1806 (2.6); 2.1754 (3.5); 2.1564 (1.8); 2.1158 (8.4); 2.0927 (8.3); 2.0797 (7.5); 2.0566 (7.4); 1.9860 (0.6); 1.8107 (2.2); 1.7994 (2.4); 1.7966 (2.8); 1.7858 (3.2); 1.7761 (3.1); 1.7728 (2.6); 1.7666 (2.5); 1.7632 (3.1); 1.7524 (2.8); 1.7429 (2.1); 1.7399 (1.9); 1.7284 (1.8); 0.0079 (1.8); -0.0002 (67.7); -0.0085 (2.2) I.1-240: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2606 (70.3); 7.2152 (1.3); 7.1965 (3.2); 7.1777 (2.0); 7.1054 (0.6); 7.0917 (1.2); 7.0797 (0.7); 7.0733 (1.0); 7.0648 (1.9); 7.0596 (2.2); 7.0490 (1.5); 7.0456 (3.6); 7.0392 (3.8); 7.0357 (2.7); 7.0311 (4.0); 7.0222 (1.6); 6.9966 (0.6); 6.9864 (2.8); 6.9702 (1.7); 6.9512 (1.4); 5.3741 (0.8); 4.8420 (1.5); 4.8385 (1.6); 4.8033 (1.7); 4.7997 (1.7); 4.2253 (2.2); 4.1866 (2.0); 3.9306 (0.8); 3.9197 (0.9); 3.9091 (1.0); 3.8997 (0.9); 3.8887 (0.8); 3.5295 (0.9); 3.5123 (2.1); 3.4970 (3.3); 3.4817 (2.0); 3.4650 (1.0); 2.7739 (2.6); 2.7567 (5.3); 2.7395 (2.4); 2.5772 (1.6); 2.5663 (1.5); 2.5412 (1.8); 2.5303 (1.8); 2.4668 (1.2); 2.4475 (1.0); 2.4439 (1.0); 2.4244 (1.0); 2.4139 (1.2); 2.3992 (1.3); 2.3899 (1.6); 2.3754 (1.6); 2.3712 (0.6); 2.3469 (0.7); 2.3276 (16.0); 2.2669 (0.6); 2.2478 (1.0); 2.2431 (0.6); 2.2343 (0.7); 2.2288 (0.6); 2.2238 (0.8); 2.2152 (1.0); 2.2103 (0.6); 2.1961 (0.6); 2.1910 (0.8); 2.1057 (2.0); 2.0833 (1.9); 2.0697 (1.7); 2.0473 (1.7); 1.8160 (0.5); 1.8046 (0.6); 1.8019 (0.7); 1.7908 (0.8); 1.7813 (0.7); 1.7780 (0.6); 1.7719 (0.6); 1.7687 (0.7); 1.7576 (0.6); 1.7484 (0.5); 1.6474 (0.8); 0.0080 (0.6); -0.0002 (18.1) I.1-241: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.4940 (0.7); 8.2483 (1.5); 8.2290 (1.4); 7.1444 (1.4); 7.1238 (8.8); 7.1155 (9.5); 7.0943 (1.6); 4.6609 (1.9); 4.6224 (2.1); 4.1992 (0.6); 4.1848 (0.9); 4.1788 (0.8); 4.1652 (0.9); 4.1417 (0.6); 4.0209 (2.0); 3.9830 (1.7); 3.9090 (0.9); 3.6991 (0.7); 3.6883 (0.8); 3.6756 (0.9); 3.6657 (0.8); 3.6555 (0.6); 3.3532 (0.5); 3.3164 (53.5); 3.1634 (1.0); 2.6744 (1.3); 2.6698 (1.9); 2.6650 (1.4); 2.5717 (1.4); 2.5634 (1.4); 2.5445 (1.7); 2.5398 (3.0); 2.5302 (0.8); 2.5232 (3.4); 2.5185 (5.8); 2.5098 (100.7); 2.5053 (223.1); 2.5006 (314.6); 2.4960 (219.7); 2.4914 (98.4); 2.4731 (2.3); 2.4685 (1.6); 2.3743 (0.6); 2.3542 (1.0); 2.3321 (2.2); 2.3275 (2.1); 2.3229 (1.5); 2.3114 (0.9); 2.2760 (16.0); 2.2567 (1.1); 2.2461 (1.2); 2.2328 (1.1); 2.2151 (0.6); 2.2040 (0.6); 2.1911 (0.6); 2.1751 (1.4); 2.1517 (1.4); 2.1409 (1.2); 2.1175 (1.3); 2.0732 (0.9); 2.0226 (0.7); 1.9989 (0.7); 1.9910 (0.9); 1.9662 (0.7); 1.7716 (0.5); 1.7611 (0.9); 1.7515 (0.7); 1.7388 (0.7); 1.7288 (0.6); 1.5957 (0.7); 1.5803 (0.6); 1.5107 (1.3); 1.4987 (2.0); 1.4846 (1.9); 1.4751 (1.4); 1.4624 (1.1); 0.8937 (9.3); 0.8773 (8.9); 0.8285 (9.1); 0.8123 (9.0); 0.0081 (3.5); -0.0002 (129.9); -0.0085 (3.5); -0.0330 (0.6) I.1-242: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.4782 (1.1); 7.3908 (0.5); 7.3752 (0.5); 7.3557 (0.4); 7.0906 (0.5); 7.0813 (0.8); 7.0606 (1.0); 7.0303 (0.5); 4.6714 (0.7); 4.6321 (0.8); 4.1460 (0.8); 4.1067 (0.7); 3.7890 (0.3); 3.7780 (0.4); 3.7682 (0.3); 3.3164 (8.6); 2.7726 (16.0); 2.7288 (0.5); 2.7184 (0.5); 2.6912 (0.5); 2.6808 (0.5); 2.5089 (5.5); 2.5046 (11.8); 2.5001 (16.5); 2.4957 (12.6); 2.3955 (0.4); 2.3744 (0.9); 2.3524 (0.8); 2.3368 (0.5); 2.3222 (0.4); 2.3146 (0.5); 2.3089 (0.4); 2.2979 (0.4); 2.2843 (0.4); 2.0709 (0.8); 0.0000 (2.7) I.1-243: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9112 (1.8); 8.8898 (1.9); 7.3503 (1.2); 7.3480 (2.0); 7.3436 (1.9); 7.3412 (2.2); 7.3375 (1.4); 7.3298 (3.8); 7.3273 (5.4); 7.3230 (3.7); 7.3206 (4.5); 7.3112 (5.2); 7.3045 (4.5); 7.2638 (9.0); 7.2540 (8.7); 7.2458 (6.3); 7.2360 (5.9); 7.2274 (1.4); 7.2238 (0.6); 7.2206 (0.6); 7.2170 (0.9); 7.1155 (2.5); 7.0956 (6.7); 7.0737 (7.6); 7.0532 (2.7); 6.1145 (2.3); 6.0931 (2.3); 4.6523 (1.9); 4.6143 (2.1); 3.9910 (2.2); 3.9531 (2.0); 3.7351 (0.7); 3.7243 (0.9); 3.7140 (1.1); 3.7041 (0.9); 3.6934 (0.7); 3.3257 (17.3); 2.6441 (1.3); 2.6330 (1.3); 2.6095 (1.6); 2.5983 (1.5); 2.5088 (6.6); 2.5042 (14.3); 2.4996 (20.0); 2.4950 (14.0); 2.4904 (6.2); 2.3525 (0.5); 2.3332 (1.2); 2.3216 (1.8); 2.3146 (1.1); 2.3105 (1.1); 2.2994 (1.7); 2.2870 (1.6); 2.2620 (16.0); 2.2437 (1.2); 2.2333 (1.2); 2.2196 (1.2); 2.2159 (0.7); 2.2019 (0.6); 2.1915 (0.6); 2.1779 (0.6); 2.0712 (8.4); 2.0254 (0.7); 2.0209 (0.5); 2.0129 (0.6); 2.0062 (0.5); 2.0012 (0.7); 1.9938 (0.9); 1.9890 (0.6); 1.9743 (0.5); 1.9696 (0.7); 1.7253 (0.6); 1.7146 (0.8); 1.7042 (0.7); 1.6930 (0.7); 1.6826 (0.7); -0.0002 (2.4) I.1-244: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4244 (0.9); 7.4068 (2.3); 7.3879 (2.0); 7.3624 (0.8); 7.3457 (0.7); 7.1934 (3.6); 7.1896 (5.3); 7.1844 (1.2); 7.1722 (3.6); 7.0930 (2.1); 7.0743 (2.6); 6.9680 (1.6); 6.9504 (1.3); 4.4167 (0.6); 4.3796 (0.6); 3.9338 (0.7); 3.8984 (0.6); 3.7518 (0.8); 3.7417 (0.7); 3.3198 (103.0); 3.1682 (0.5); 3.1079 (4.8); 2.6697 (0.6); 2.5231 (1.2); 2.5184 (1.8); 2.5098 (33.4); 2.5052 (72.9); 2.5006 (102.3); 2.4960 (71.7); 2.4914 (32.4); 2.4499 (0.6); 2.4391 (0.6); 2.4036 (0.6); 2.3273 (0.6); 2.2819 (16.0); 2.1961 (1.2); 2.1814 (0.9); 2.1029 (0.6); 2.0827 (0.6); 2.0719 (0.9); 2.0505 (0.5); -0.0002 (0.6) I.1-246: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5201 (0.5); 7.5182 (0.5); 7.2613 (82.2); 7.2593 (80.8); 7.1275 (0.4); 7.1150 (0.9); 7.1029 (1.6); 7.0924 (1.1); 7.0849 (1.7); 7.0782 (1.7); 7.0692 (1.0); 7.0590 (6.4); 7.0487 (6.1); 7.0412 (2.1); 7.0363 (2.0); 6.9974 (0.5); 6.9955 (0.4); 4.8980 (2.5); 4.8595 (2.8); 4.7241 (1.1); 4.7131 (1.2); 4.6968 (2.2); 4.6859 (2.3); 4.6695 (1.2); 4.6584 (1.1); 4.2514 (3.7); 4.2126 (3.3); 3.9077 (0.5); 3.8965 (1.0); 3.8858 (1.5); 3.8754 (1.6); 3.8648 (1.5); 3.8541 (1.1); 3.8429 (0.6); 2.7495 (2.2); 2.7398 (2.2); 2.7112 (2.7); 2.7015 (2.7); 2.5585 (0.6); 2.5411 (0.8); 2.5341 (0.7); 2.5159 (1.9); 2.4981 (1.6); 2.4915 (1.5); 2.4741 (1.6); 2.4425 (1.3); 2.4272 (1.5); 2.4181 (1.9); 2.4021 (2.0); 2.3846 (3.2); 2.3752 (1.1); 2.3608 (3.5); 2.3463 (2.3); 2.3235 (2.2); 2.3064 (0.8); 2.2875 (1.2); 2.2730 (0.9); 2.2631 (0.9); 2.2549 (1.4); 2.2497 (0.9); 2.2355 (0.8); 2.2304 (1.0); 2.2121 (0.5); 1.9448 (1.3); 1.9154 (1.4); 1.8476 (0.7); 1.8342 (1.1); 1.8219 (1.5); 1.8098 (2.0); 1.8019 (2.0); 1.7911 (2.1); 1.7865 (1.9); 1.7754 (1.6); 1.7675 (1.2); 1.7571 (0.5); 1.7505 (0.5); 1.6912 (2.6); 1.6831 (2.1); 1.6643 (2.6); 1.6578 (2.6); 1.6497 (1.8); 1.6427 (0.7); 1.5553 (22.8); 1.5209 (0.3); 1.5111 (0.5); 1.5035 (0.5); 1.4900 (0.8); 1.4812 (0.9); 1.4736 (0.9); 1.4656 (1.0); 1.4578 (0.8); 1.4521 (0.7); 1.4440 (0.6); 1.4360 (0.5); 1.4274 (0.3); 1.3865 (0.6); 1.3789 (0.9); 1.3719 (0.6); 1.3496 (1.6); 1.3283 (0.7); 1.3210 (1.1); 1.3135 (0.6); 1.0953 (0.4); 1.0847 (0.6); 1.0590 (1.2); 1.0531 (1.3); 1.0281 (1.6); 1.0203 (1.3); 0.9964 (0.6); 0.9885 (0.6); 0.9779 (1.2); 0.9484 (2.9); 0.9192 (3.1); 0.9095 (15.0); 0.9013 (16.0); 0.8933 (15.0); 0.8839 (14.6); 0.8685 (1.8); 0.8448 (1.2); 0.8137 (0.5); 0.7498 (14.3); 0.7324 (14.0); 0.0061 (1.3) I.1-247: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5979 (0.5); 8.5851 (0.7); 8.5706 (8.8); 8.5685 (10.2); 8.5664 (10.6); 8.5642 (9.4); 8.5582 (9.3); 8.5560 (10.7); 8.5540 (10.4); 8.5517 (9.2); 7.8983 (6.0); 7.8939 (6.1); 7.8790 (11.7); 7.8746 (11.8); 7.8597 (6.9); 7.8553 (6.8); 7.4494 (0.6); 7.4385 (0.5); 7.3955 (7.4); 7.3829 (7.9); 7.3792 (7.0); 7.3767 (7.0); 7.3632 (13.9); 7.3610 (14.2); 7.3411 (12.3); 7.3229 (0.5); 4.7555 (13.4); 4.7150 (16.0); 4.4884 (0.6); 4.4732 (0.6); 4.4305 (1.2); 4.4222 (1.6); 4.4075 (1.1); 4.3904 (1.2); 4.3759 (1.2); 4.3253 (15.0); 4.2848 (13.0); 4.2337 (1.3); 4.1082 (1.6); 3.9353 (1.1); 3.9247 (1.1); 3.9144 (1.0); 3.8991 (2.8); 3.8885 (4.2); 3.8770 (5.9); 3.8692 (5.7); 3.8665 (5.8); 3.8579 (5.8); 3.8471 (4.6); 3.8360 (2.3); 3.1686 (0.7); 2.9967 (0.5); 2.7230 (9.6); 2.7129 (9.9); 2.6832 (12.2); 2.6731 (12.2); 2.5249 (1.3); 2.5201 (2.1); 2.5115 (41.0); 2.5069 (90.2); 2.5023 (127.1); 2.4977 (90.3); 2.4931 (41.2); 2.4617 (0.7); 2.4570 (1.1); 2.4518 (3.2); 2.4434 (1.1); 2.4352 (3.4); 2.4210 (1.5); 2.4104 (7.8); 2.3918 (16.2); 2.3870 (7.2); 2.3744 (3.4); 2.3693 (12.7); 2.3599 (2.8); 2.3521 (11.3); 2.3295 (11.0); 2.3199 (0.9); 2.3110 (4.8); 2.2974 (4.6); 2.2867 (9.4); 2.2734 (9.2); 2.2471 (12.7); 2.2396 (6.9); 2.2379 (6.8); 2.2331 (5.6); 2.2290 (4.2); 2.2234 (2.1); 2.2170 (4.9); 2.2149 (4.6); 2.2088 (2.4); 2.2046 (2.0); 2.1978 (3.6); 2.1927 (2.5); 2.1905 (2.7); 2.1734 (1.9); 1.7883 (1.5); 1.7830 (0.9); 1.7647 (3.3); 1.7614 (3.9); 1.7534 (5.7); 1.7475 (3.5); 1.7422 (4.2); 1.7358 (3.0); 1.7284 (4.2); 1.7237 (4.0); 1.7112 (3.7); 1.6980 (2.2); 0.0080 (0.5); -0.0002 (18.6); -0.0086 (0.6) I.1-248: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5212 (1.0); 7.3558 (5.6); 7.3360 (11.8); 7.3162 (7.9); 7.2729 (0.6); 7.2721 (0.7); 7.2713 (0.7); 7.2705 (0.8); 7.2697 (0.9); 7.2680 (1.4); 7.2622 (188.6); 7.1213 (6.8); 7.1103 (5.7); 7.1037 (9.1); 7.0965 (5.2); 7.0869 (5.2); 7.0840 (5.7); 7.0807 (4.5); 7.0779 (3.6); 7.0703 (4.9); 7.0640 (1.6); 7.0588 (2.0); 7.0535 (4.5); 7.0509 (9.6); 7.0440 (9.0); 7.0406 (7.1); 7.0359 (12.4); 7.0273 (6.4); 7.0248 (7.3); 7.0171 (7.6); 6.9982 (1.1); 5.4464 (2.4); 4.8443 (4.8); 4.8407 (4.8); 4.8056 (5.4); 4.8019 (5.4); 4.2387 (6.9); 4.1999 (6.2); 3.9469 (1.1); 3.9358 (2.3); 3.9250 (2.9); 3.9148 (3.2); 3.9049 (2.9); 3.8939 (2.4); 3.8829 (1.2); 3.5743 (0.6); 3.5566 (1.4); 3.5403 (3.0); 3.5226 (5.6); 3.5175 (2.6); 3.5074 (5.4); 3.5049 (4.1); 3.5002 (5.3); 3.4898 (2.9); 3.4851 (5.5); 3.4680 (3.0); 3.4510 (1.3); 3.4338 (0.6); 2.8432 (8.2); 2.8258 (16.0); 2.8083 (7.3); 2.5915 (4.9); 2.5806 (4.9); 2.5553 (5.7); 2.5444 (5.6); 2.5163 (1.0); 2.4963 (1.3); 2.4931 (1.2); 2.4734 (3.5); 2.4534 (3.2); 2.4500 (3.1); 2.4304 (3.1); 2.4201 (3.6); 2.4053 (4.2); 2.3960 (5.0); 2.3814 (5.0); 2.3773 (1.8); 2.3625 (1.4); 2.3530 (2.2); 2.3386 (2.1); 2.2718 (1.9); 2.2527 (2.9); 2.2480 (1.8); 2.2392 (2.3); 2.2338 (1.8); 2.2287 (2.4); 2.2203 (3.2); 2.2152 (2.1); 2.2098 (1.4); 2.2011 (2.0); 2.1959 (2.5); 2.1769 (1.3); 2.1280 (6.3); 2.1056 (6.2); 2.0918 (5.6); 2.0695 (5.6); 2.0061 (0.6); 1.8106 (1.6); 1.7992 (1.8); 1.7964 (2.1); 1.7852 (2.2); 1.7758 (2.2); 1.7727 (1.9); 1.7665 (1.9); 1.7633 (2.3); 1.7543 (1.7); 1.7520 (2.0); 1.7430 (1.6); 1.7399 (1.5); 1.7283 (1.3); 0.0080 (1.6); 0.0048 (0.6); -0.0002 (55.5); -0.0085 (1.6) I.1-250: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9170 (2.3); 7.9128 (14.2); 7.9084 (4.8); 7.8964 (5.1); 7.8919 (16.0); 7.8877 (2.7); 7.8806 (0.7); 7.3502 (12.4); 7.3293 (11.6); 4.7296 (4.9); 4.6899 (5.6); 4.2365 (5.5); 4.1969 (4.8); 3.7626 (1.0); 3.7519 (1.7); 3.7410 (2.4); 3.7321 (2.4); 3.7207 (2.4); 3.7101 (1.9); 3.6995 (1.0); 2.6818 (3.6); 2.6718 (4.1); 2.6420 (4.6); 2.6321 (4.2); 2.5252 (0.7); 2.5204 (1.1); 2.5118 (17.4); 2.5072 (37.1); 2.5026 (51.4); 2.4979 (36.8); 2.4934 (17.1); 2.4640 (1.2); 2.4461 (1.1); 2.4394 (1.2); 2.4224 (2.8); 2.4047 (2.2); 2.3988 (2.0); 2.3817 (1.8); 2.3410 (4.7); 2.3293 (0.7); 2.3185 (5.4); 2.3068 (2.4); 2.3012 (4.4); 2.2965 (3.3); 2.2822 (3.5); 2.2787 (5.2); 2.2659 (0.8); 2.2547 (1.8); 2.2418 (2.0); 2.2269 (1.3); 2.2086 (1.7); 2.2028 (0.9); 2.1963 (1.5); 2.1909 (1.3); 2.1840 (1.3); 2.1784 (2.0); 2.1722 (1.3); 2.1666 (0.9); 2.1591 (1.3); 2.1536 (1.3); 2.1348 (0.7); 1.7550 (0.9); 1.7431 (1.5); 1.7317 (1.9); 1.7240 (1.4); 1.7208 (1.6); 1.7124 (1.8); 1.7072 (1.3); 1.7001 (1.8); 1.6888 (1.2); 1.6754 (0.8); 0.0081 (0.6); -0.0002 (19.7); -0.0085 (0.6) I.1-251: 1H-NMR (400.0 MHz, CDCl3): δ= 7.3710 (3.4); 7.3505 (3.7); 7.2618 (34.8); 7.2403 (2.7); 7.2351 (2.8); 7.1164 (29.3); 7.0003 (1.6); 6.9951 (1.6); 6.9798 (1.4); 6.9746 (1.4); 5.3852 (0.6); 5.2987 (1.1); 4.6996 (1.8); 4.6620 (2.0); 4.1348 (1.8); 4.0973 (1.6); 3.9439 (0.6); 3.9336 (0.7); 3.9233 (1.1); 3.9130 (0.7); 3.9028 (0.6); 3.4661 (0.8); 3.4481 (1.2); 3.4326 (1.2); 3.4301 (1.0); 3.4147 (1.1); 3.4120 (1.1); 3.3970 (1.2); 3.3796 (0.7); 2.7421 (2.0); 2.7246 (4.0); 2.7070 (1.8); 2.4998 (1.2); 2.4884 (1.3); 2.4713 (0.9); 2.4637 (1.5); 2.4521 (2.2); 2.4288 (0.8); 2.4238 (0.9); 2.4093 (1.0); 2.3996 (1.1); 2.3854 (1.1); 2.3426 (0.5); 2.3240 (16.0); 2.2123 (0.7); 2.1991 (0.5); 2.1882 (0.6); 2.1798 (0.8); 2.1555 (0.6); 2.0796 (1.5); 2.0583 (1.4); 2.0435 (1.3); 2.0222 (1.2); 1.7360 (0.6); 1.7264 (0.6); 1.7132 (0.6); -0.0002 (9.8) I.1-252: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5196 (1.8); 7.3109 (0.6); 7.3086 (0.5); 7.2977 (0.3); 7.2609 (311.4); 7.1347 (4.1); 7.1305 (1.7); 7.1139 (12.8); 7.1002 (4.9); 7.0936 (11.6); 7.0888 (11.5); 7.0682 (9.4); 7.0044 (4.8); 6.9971 (6.7); 6.9888 (4.4); 6.9829 (3.6); 6.9780 (3.6); 6.9726 (3.2); 5.6899 (0.8); 5.5264 (0.3); 5.4750 (3.9); 5.2984 (0.9); 4.6505 (9.3); 4.6123 (11.0); 4.2807 (1.6); 4.2426 (1.4); 4.1944 (10.8); 4.1564 (9.2); 4.1306 (0.4); 4.1182 (0.6); 4.1105 (0.7); 4.0992 (1.0); 4.0912 (0.5); 4.0872 (0.6); 4.0789 (0.7); 4.0664 (2.1); 4.0543 (2.9); 4.0470 (4.1); 4.0416 (2.8); 4.0352 (5.5); 4.0274 (2.8); 4.0222 (4.3); 4.0158 (3.1); 4.0028 (2.0); 3.2425 (0.5); 2.7307 (0.9); 2.7182 (1.0); 2.7021 (1.1); 2.6921 (3.2); 2.6843 (4.9); 2.6754 (6.7); 2.6666 (6.3); 2.6573 (4.7); 2.6488 (2.7); 2.6396 (1.1); 2.5670 (0.4); 2.5610 (0.4); 2.5479 (1.8); 2.5357 (0.4); 2.5243 (2.8); 2.5049 (6.2); 2.4836 (7.2); 2.4624 (6.6); 2.4490 (5.2); 2.4432 (2.6); 2.4346 (12.4); 2.4248 (7.9); 2.4209 (8.7); 2.4110 (7.3); 2.4061 (3.2); 2.3975 (9.7); 2.3923 (3.3); 2.3837 (11.2); 2.3682 (3.5); 2.3515 (0.6); 2.3402 (0.6); 2.3321 (0.7); 2.3210 (0.4); 2.3103 (3.0); 2.2910 (4.7); 2.2868 (2.4); 2.2779 (3.1); 2.2715 (2.6); 2.2671 (3.6); 2.2585 (5.1); 2.2539 (2.9); 2.2477 (1.9); 2.2388 (2.8); 2.2345 (3.9); 2.2150 (1.8); 2.1191 (8.9); 2.0999 (8.8); 2.0823 (7.3); 2.0631 (7.1); 2.0333 (0.4); 2.0046 (0.5); 1.9698 (0.7); 1.8775 (3.4); 1.8753 (3.4); 1.8124 (1.5); 1.7996 (1.6); 1.7929 (3.2); 1.7811 (4.0); 1.7690 (4.9); 1.7596 (4.4); 1.7460 (4.4); 1.7366 (3.7); 1.7257 (2.7); 1.7119 (2.0); 1.6951 (0.4); 0.8312 (0.3); 0.8257 (0.4); 0.8142 (0.6); 0.8049 (4.7); 0.7875 (16.0); 0.7738 (14.1); 0.7698 (12.7); 0.7664 (7.1); 0.7569 (5.4); 0.7361 (0.8); 0.7286 (0.5); 0.7162 (0.6); 0.5645 (0.4); 0.5540 (0.5); 0.5379 (0.6); 0.5274 (1.0); 0.5150 (1.2); 0.5045 (0.7); 0.4729 (5.4); 0.4629 (11.4); 0.4596 (12.5); 0.4564 (12.9); 0.4538 (12.2); 0.4500 (12.7); 0.4470 (12.0); 0.4332 (4.6); 0.4162 (0.4); 0.1464 (0.5); 0.0081 (3.5); 0.0000 (117.6) I.1-254: 1H-NMR (400.1 MHz, d6-DMSO): δ= 8.3599 (0.7); 8.3510 (1.1); 8.3400 (0.8); 8.3308 (1.0); 7.3878 (0.5); 7.3840 (0.5); 7.3672 (1.0); 7.3634 (1.1); 7.3575 (0.6); 7.3475 (0.7); 7.3415 (1.1); 7.3376 (1.0); 7.3211 (0.6); 7.3175 (0.6); 7.2526 (1.0); 7.2343 (2.3); 7.2285 (1.4); 7.2226 (1.4); 7.2170 (1.2); 7.2117 (1.6); 7.2056 (2.4); 7.2000 (1.8); 7.1931 (2.8); 7.1880 (2.4); 7.1833 (1.8); 7.1749 (2.7); 7.1713 (2.5); 7.1583 (1.7); 7.1537 (2.6); 7.1360 (1.3); 7.1226 (0.5); 7.1182 (0.4); 7.0947 (1.1); 7.0786 (1.5); 7.0595 (0.8); 5.2670 (0.8); 5.2492 (1.4); 5.2304 (1.2); 5.2116 (0.4); 4.7613 (1.8); 4.7216 (2.0); 4.2776 (1.4); 4.2673 (0.9); 4.2377 (1.2); 4.2275 (0.8); 3.8763 (0.5); 3.8657 (0.8); 3.8552 (1.1); 3.8451 (1.2); 3.8351 (0.9); 3.8246 (0.6); 3.4148 (16.0); 3.1685 (0.7); 2.9503 (0.3); 2.9406 (0.4); 2.9292 (0.4); 2.9193 (0.5); 2.9115 (0.7); 2.9017 (0.8); 2.8896 (0.7); 2.8799 (0.7); 2.8251 (0.6); 2.8045 (1.3); 2.7841 (1.0); 2.7746 (0.8); 2.7649 (0.7); 2.7449 (0.4); 2.6693 (0.4); 2.5985 (0.9); 2.5873 (1.0); 2.5823 (0.7); 2.5708 (0.7); 2.5639 (1.2); 2.5526 (1.3); 2.5480 (1.0); 2.5397 (0.7); 2.5363 (0.8); 2.5228 (0.8); 2.5180 (1.3); 2.5094 (22.6); 2.5049 (50.1); 2.5003 (70.6); 2.4957 (51.3); 2.4911 (24.5); 2.4246 (0.4); 2.4011 (0.9); 2.3913 (0.6); 2.3818 (1.8); 2.3702 (1.2); 2.3603 (1.8); 2.3502 (1.2); 2.3402 (1.6); 2.3310 (0.7); 2.3274 (0.8); 2.3180 (0.7); 2.3055 (0.8); 2.2929 (1.2); 2.2816 (1.3); 2.2765 (1.2); 2.2694 (2.0); 2.2548 (1.0); 2.2483 (1.4); 2.2406 (1.2); 2.2352 (1.2); 2.2274 (0.7); 2.2204 (0.9); 2.2136 (1.1); 2.2014 (0.4); 2.1911 (0.5); 2.1777 (0.4); 2.1716 (0.8); 2.1601 (0.6); 2.1483 (0.7); 2.1411 (0.7); 2.1366 (0.5); 2.1291 (0.3); 2.1217 (0.4); 2.1171 (0.5); 1.8401 (0.4); 1.8346 (0.4); 1.8282 (0.5); 1.8239 (0.5); 1.8169 (0.8); 1.8045 (0.8); 1.7970 (0.6); 1.7930 (0.7); 1.7857 (0.6); 1.7749 (0.4); 1.7659 (0.6); 1.7445 (1.2); 1.7343 (0.6); 1.7243 (1.1); 1.7131 (1.1); 1.7043 (0.5); 1.6928 (1.0); 1.6728 (0.3); 0.0082 (0.6) I.1-255: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9634 (3.8); 8.9592 (4.2); 8.9523 (4.1); 8.9481 (4.0); 8.6792 (1.2); 8.6644 (2.4); 8.6498 (1.2); 8.5056 (2.4); 8.4860 (2.5); 8.0392 (4.6); 8.0175 (5.3); 7.8521 (4.7); 7.8490 (4.9); 7.7265 (3.7); 7.7217 (3.4); 7.7047 (3.2); 7.6998 (3.0); 7.6571 (3.4); 7.6460 (3.4); 7.6363 (3.3); 7.6253 (3.3); 7.3786 (0.7); 7.3747 (0.8); 7.3581 (1.6); 7.3542 (1.7); 7.3480 (0.9); 7.3384 (1.2); 7.3324 (1.7); 7.3280 (1.4); 7.3119 (0.9); 7.3079 (0.9); 7.2057 (0.9); 7.2018 (1.0); 7.1929 (1.0); 7.1891 (1.2); 7.1857 (1.8); 7.1821 (1.9); 7.1730 (1.7); 7.1696 (2.0); 7.1655 (1.2); 7.1615 (1.2); 7.1526 (1.0); 7.1491 (1.0); 7.0861 (1.9); 7.0701 (2.5); 7.0668 (2.4); 7.0507 (1.3); 4.7617 (2.8); 4.7221 (3.2); 4.5217 (0.8); 4.5074 (0.8); 4.4832 (2.8); 4.4686 (2.9); 4.4590 (2.8); 4.4447 (2.9); 4.4201 (0.9); 4.4059 (0.9); 4.2547 (3.8); 4.2150 (3.4); 4.0404 (0.8); 3.8749 (1.0); 3.8643 (1.6); 3.8539 (2.1); 3.8437 (2.4); 3.8337 (2.0); 3.8234 (1.5); 3.8128 (0.9); 3.1679 (16.0); 3.1127 (0.8); 3.1007 (0.7); 3.0945 (0.8); 3.0825 (0.7); 2.7669 (1.3); 2.7553 (1.0); 2.6714 (0.6); 2.6668 (0.5); 2.6546 (2.2); 2.6435 (2.3); 2.6194 (2.8); 2.6083 (2.6); 2.5249 (1.0); 2.5202 (1.7); 2.5115 (31.3); 2.5069 (69.6); 2.5023 (97.9); 2.4977 (69.2); 2.4931 (31.2); 2.4155 (0.7); 2.3963 (1.0); 2.3919 (1.0); 2.3733 (1.9); 2.3547 (4.6); 2.3332 (4.3); 2.3245 (1.0); 2.3196 (2.7); 2.2979 (3.7); 2.2841 (1.9); 2.2733 (2.4); 2.2601 (2.3); 2.2558 (1.1); 2.2426 (0.9); 2.2314 (1.3); 2.2187 (1.3); 2.1855 (0.9); 2.1663 (1.4); 2.1617 (0.8); 2.1543 (1.1); 2.1472 (0.9); 2.1423 (1.2); 2.1351 (1.7); 2.1304 (1.0); 2.1232 (0.6); 2.1155 (1.0); 2.1108 (1.2); 2.0915 (0.6); 2.0746 (0.5); 1.8426 (0.8); 1.8305 (1.2); 1.8194 (1.6); 1.8091 (1.3); 1.7988 (1.3); 1.7879 (1.4); 1.7771 (0.9); 1.7642 (0.6); 1.1974 (1.6); 1.1792 (3.6); 1.1609 (1.6); 1.0511 (1.1); 1.0332 (0.5); 0.0080 (1.5); 0.0048 (0.5); 0.0040 (0.7); 0.0023 (2.0); -0.0002 (51.2); -0.0058 (0.6); - 0.0067 (0.5); -0.0085 (1.4) I.1-257: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2693 (1.6); 8.2496 (1.7); 7.7032 (0.5); 7.1433 (1.9); 7.1230 (8.1); 7.1112 (8.9); 7.0901 (1.8); 4.6608 (1.9); 4.6227 (2.1); 4.2432 (0.6); 4.2291 (0.9); 4.2196 (0.9); 4.2081 (1.0); 4.1854 (0.7); 4.0554 (2.2); 4.0176 (2.0); 3.7197 (0.7); 3.7093 (0.9); 3.6991 (1.1); 3.6890 (0.9); 3.6789 (0.7); 3.3480 (7.8); 3.1638 (0.5); 2.6744 (0.6); 2.6698 (0.9); 2.6652 (0.7); 2.5383 (0.8); 2.5336 (1.4); 2.5277 (2.5); 2.5234 (3.1); 2.5185 (4.0); 2.5099 (51.7); 2.5053 (112.9); 2.5007 (157.3); 2.4961 (109.6); 2.4915 (48.8); 2.4823 (1.8); 2.4607 (0.6); 2.4565 (0.7); 2.3472 (1.1); 2.3276 (1.8); 2.3051 (1.0); 2.2759 (16.0); 2.2542 (1.0); 2.2440 (1.1); 2.2302 (1.2); 2.2151 (1.7); 2.2019 (0.7); 2.1933 (1.7); 2.1811 (1.4); 2.1591 (1.2); 2.0320 (0.6); 2.0194 (0.6); 2.0081 (0.7); 2.0009 (0.9); 1.9759 (0.6); 1.7176 (0.6); 1.7057 (0.8); 1.6956 (0.7); 1.6840 (0.7); 1.6736 (0.7); 1.6001 (0.7); 1.5867 (0.8); 1.5106 (1.4); 1.4990 (1.9); 1.4854 (2.0); 1.4740 (1.3); 1.4632 (1.1); 0.8911 (9.8); 0.8748 (9.4); 0.8248 (9.9); 0.8086 (9.7); 0.0080 (1.7); 0.0048 (0.7); -0.0002 (54.7); -0.0085 (1.4) I.1-260: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6537 (0.6); 8.6390 (1.2); 8.6231 (0.6); 7.1471 (1.9); 7.1268 (7.1); 7.1127 (7.8); 7.0919 (1.9); 4.6712 (1.9); 4.6334 (2.1); 4.0155 (2.2); 3.9776 (1.9); 3.9324 (0.6); 3.9164 (0.7); 3.9077 (1.9); 3.8917 (1.8); 3.8830 (2.0); 3.8670 (1.9); 3.8583 (0.7); 3.8421 (0.6); 3.7341 (0.7); 3.7233 (0.9); 3.7124 (1.0); 3.7025 (0.9); 3.6916 (0.7); 3.3165 (134.4); 2.6698 (0.6); 2.6187 (1.4); 2.6077 (1.4); 2.5835 (1.6); 2.5727 (1.6); 2.5232 (1.5); 2.5185 (2.2); 2.5098 (35.4); 2.5052 (77.1); 2.5006 (107.8); 2.4960 (75.4); 2.4914 (33.8); 2.3548 (1.1); 2.3321 (1.3); 2.3277 (0.9); 2.3229 (0.6); 2.3128 (0.8); 2.2765 (16.0); 2.2627 (1.2); 2.2521 (1.4); 2.2460 (1.9); 2.2385 (1.3); 2.2232 (1.8); 2.2106 (2.0); 2.1966 (0.7); 2.1880 (1.4); 2.0577 (0.7); 2.0452 (0.6); 2.0337 (0.7); 2.0259 (0.9); 2.0212 (0.6); 2.0069 (0.5); 2.0019 (0.7); 1.6941 (0.6); 1.6833 (0.8); 1.6731 (0.7); 1.6616 (0.6); 1.6512 (0.7) I.1-261: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2012 (2.2); 9.1931 (2.2); 8.3078 (0.5); 6.9931 (1.3); 6.9901 (1.4); 6.9720 (1.6); 6.9690 (1.4); 6.6578 (1.5); 6.6497 (1.5); 6.6446 (0.5); 6.6415 (0.5); 6.6365 (1.4); 6.6284 (1.4); 3.3219 (22.1); 3.2981 (0.5); 2.8333 (0.6); 2.8182 (0.5); 2.5193 (0.5); 2.5108 (5.1); 2.5062 (10.9); 2.5016 (15.3); 2.4970 (10.7); 2.4924 (4.9); 2.2171 (0.8); 2.1965 (0.7); 2.1831 (0.6); 2.0857 (2.9); 1.3266 (16.0); 1.3198 (15.8) I.1-262: 1H-NMR (400.0 MHz, CDCl3): δ= 7.3405 (0.8); 7.3196 (1.0); 7.2610 (7.5); 7.1102 (0.9); 7.0893 (0.8); 7.0301 (0.6); 2.7640 (0.8); 1.3063 (16.0); -0.0002 (2.0) I.1-264: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5180 (3.6); 7.3597 (0.5); 7.3096 (1.7); 7.3000 (0.5); 7.2886 (0.7); 7.2764 (1.1); 7.2593 (651.7); 7.1600 (0.9); 7.1551 (1.3); 7.1337 (9.7); 7.1290 (9.5); 7.1071 (1.1); 6.9954 (3.7); 5.2199 (0.9); 4.7489 (2.0); 4.7116 (2.4); 4.1742 (2.3); 4.1362 (2.0); 3.9797 (0.4); 3.9674 (0.8); 3.9567 (1.0); 3.9463 (1.2); 3.9367 (1.0); 3.9258 (0.8); 3.9148 (0.4); 3.6476 (0.4); 3.2344 (1.9); 2.5848 (1.7); 2.5737 (1.7); 2.5597 (0.5); 2.5480 (2.1); 2.5367 (2.4); 2.5158 (1.1); 2.4937 (0.9); 2.4732 (0.8); 2.4482 (1.0); 2.4336 (1.1); 2.4239 (1.3); 2.4098 (1.4); 2.3913 (0.4); 2.3810 (0.7); 2.3673 (0.8); 2.3356 (1.1); 2.3273 (16.0); 2.3043 (0.7); 2.2851 (1.0); 2.2806 (0.6); 2.2720 (0.6); 2.2662 (0.6); 2.2611 (0.7); 2.2528 (1.0); 2.2481 (0.6); 2.2424 (0.4); 2.2333 (0.6); 2.2285 (0.9); 2.2092 (0.4); 2.1851 (2.0); 2.1633 (2.0); 2.1482 (1.6); 2.1264 (1.7); 2.0039 (0.3); 1.8399 (0.5); 1.8265 (0.6); 1.8154 (0.8); 1.8052 (0.7); 1.8024 (0.7); 1.7931 (0.7); 1.7825 (0.7); 1.7719 (0.5); 1.7586 (0.4); 1.5393 (82.4); 1.4789 (0.4); 1.4609 (0.3); 1.4511 (0.3); 1.4276 (0.3); 1.4147 (0.4); 1.3335 (0.3); 1.2943 (0.4); 1.2849 (0.4); 1.2563 (1.2); 0.8344 (0.4); 0.8281 (0.4); 0.1462 (1.0); 0.0503 (0.5); 0.0081 (7.3); 0.0056 (2.4) I.1-265: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4139 (0.6); 8.3944 (0.7); 8.3892 (0.7); 8.3698 (0.6); 7.2063 (2.3); 7.1858 (4.4); 7.1433 (2.4); 7.1366 (2.5); 7.1226 (1.4); 7.1161 (1.3); 4.6958 (0.8); 4.6888 (0.8); 4.6576 (0.8); 4.6505 (0.8); 4.0206 (0.8); 4.0082 (0.8); 3.9825 (0.7); 3.9702 (0.7); 3.6079 (10.5); 3.6001 (10.4); 3.4905 (1.5); 2.8776 (0.8); 2.8602 (1.2); 2.8430 (0.9); 2.5648 (0.9); 2.5539 (0.9); 2.5312 (0.7); 2.5190 (1.2); 2.5101 (10.5); 2.5055 (22.5); 2.5009 (31.0); 2.4964 (21.7); 2.4918 (9.7); 2.3278 (0.6); 2.2528 (0.6); 2.2455 (0.7); 2.2389 (0.6); 2.2242 (0.7); 2.2106 (1.0); 2.1896 (0.6); 2.1862 (0.6); 2.0730 (0.9); 2.0203 (0.5); 1.5694 (0.5); 1.5361 (0.8); 1.5237 (0.5); 1.5112 (0.8); 1.4972 (1.1); 1.4838 (0.9); 1.4740 (0.6); 1.4616 (0.8); 1.1946 (16.0); 1.1773 (15.7); 0.8925 (4.5); 0.8780 (4.3); 0.8763 (4.3); 0.8308 (3.8); 0.8273 (4.0); 0.8146 (3.8); 0.8111 (3.7); - 0.0002 (10.9) I.1-266: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.6309 (6.1); 7.6256 (6.0); 7.4198 (2.8); 7.4144 (2.5); 7.3990 (3.4); 7.3936 (3.2); 7.2576 (4.1); 7.2367 (3.2); 4.6502 (2.0); 4.6093 (2.2); 4.2466 (2.5); 4.2057 (2.1); 3.9215 (0.8); 3.9106 (1.1); 3.9011 (1.3); 3.8909 (1.1); 3.8811 (0.9); 3.6266 (0.6); 3.6079 (1.2); 3.5902 (2.0); 3.5752 (2.1); 3.5575 (1.1); 3.5386 (0.6); 3.5206 (0.5); 3.3973 (85.9); 3.3434 (2.0); 3.2955 (1.1); 3.2378 (1.1); 3.2247 (1.1); 3.1676 (3.9); 3.1536 (2.2); 3.1397 (2.4); 3.1357 (2.4); 3.1218 (2.2); 3.1098 (1.3); 3.0466 (1.2); 3.0334 (1.8); 3.0214 (1.7); 3.0087 (1.8); 2.9945 (1.4); 2.9813 (0.9); 2.9495 (1.1); 2.9396 (1.1); 2.7673 (16.0); 2.7553 (14.9); 2.7390 (0.9); 2.7318 (0.7); 2.7162 (0.8); 2.6968 (0.7); 2.6897 (1.2); 2.6789 (0.9); 2.6745 (1.8); 2.6699 (2.0); 2.6652 (1.3); 2.5885 (0.6); 2.5490 (1.9); 2.5445 (2.7); 2.5400 (3.2); 2.5232 (6.3); 2.5186 (8.6); 2.5100 (101.4); 2.5053 (213.2); 2.5007 (293.0); 2.4961 (204.9); 2.4915 (90.3); 2.4497 (1.2); 2.4453 (2.5); 2.4407 (1.7); 2.4276 (1.2); 2.4095 (0.5); 2.4051 (1.2); 2.4003 (1.7); 2.3957 (1.6); 2.3915 (1.1); 2.3322 (1.8); 2.3275 (2.2); 2.3230 (2.1); 2.3183 (0.9); 2.3108 (1.4); 2.2995 (1.4); 2.2718 (1.9); 2.2628 (1.5); 2.2548 (0.8); 2.2485 (0.6); 2.2361 (1.0); 2.2120 (0.6); 2.0721 (1.7); 1.8409 (0.6); 1.8230 (1.4); 1.8037 (1.8); 1.7861 (1.9); 1.7666 (1.3); 1.7465 (0.6); 1.7347 (0.6); 1.0565 (7.1); 1.0385 (16.0); 1.0205 (6.8); 0.0489 (0.6); 0.0080 (2.7); -0.0002 (92.8); -0.0085 (2.5); -0.0505 (0.6) I.1-267: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3372 (0.6); 8.3233 (1.2); 8.3097 (0.6); 7.2057 (1.3); 7.2010 (1.5); 7.1902 (4.8); 7.1871 (5.4); 7.1837 (4.2); 7.1775 (3.2); 7.1744 (3.1); 7.1624 (2.5); 7.1573 (1.9); 7.1476 (1.2); 7.1413 (2.3); 7.1393 (2.2); 7.1372 (1.8); 7.1191 (6.2); 7.1019 (6.9); 7.0966 (1.5); 7.0813 (2.0); 4.6721 (1.7); 4.6342 (1.8); 4.2618 (4.2); 4.2479 (4.2); 4.0068 (1.9); 3.9689 (1.7); 3.7397 (0.6); 3.7288 (0.8); 3.7175 (0.9); 3.7083 (0.8); 3.6974 (0.7); 3.4652 (7.2); 3.1679 (0.8); 3.1523 (1.0); 2.6258 (1.4); 2.6069 (4.5); 2.5880 (5.1); 2.5743 (1.4); 2.5693 (1.7); 2.5505 (1.5); 2.5398 (1.5); 2.5232 (0.6); 2.5185 (0.8); 2.5098 (13.5); 2.5052 (29.7); 2.5006 (41.5); 2.4960 (29.2); 2.4914 (13.1); 2.3461 (1.0); 2.3273 (1.2); 2.3232 (1.0); 2.3040 (0.8); 2.2739 (13.9); 2.2577 (1.2); 2.2472 (1.2); 2.2336 (1.3); 2.2127 (1.6); 2.2054 (0.7); 2.1901 (1.7); 2.1779 (1.3); 2.1552 (1.2); 2.0624 (0.7); 2.0499 (0.5); 2.0383 (0.6); 2.0309 (0.8); 2.0260 (0.6); 2.0066 (0.6); 1.7386 (0.5); 1.7279 (0.8); 1.7175 (0.6); 1.7064 (0.6); 1.6959 (0.7); 1.1565 (6.9); 1.1377 (16.0); 1.1188 (6.8); - 0.0002 (8.2) I.1-268: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2274 (0.5); 8.9569 (1.1); 7.3921 (0.6); 7.3724 (1.2); 7.3495 (1.2); 7.3252 (0.7); 7.2149 (0.6); 7.1946 (1.3); 7.1825 (1.4); 7.1645 (0.7); 7.0621 (1.1); 7.0468 (1.6); 7.0274 (0.8); 4.6753 (1.0); 4.6347 (1.2); 4.2501 (2.1); 4.2095 (1.9); 3.8530 (1.2); 3.5683 (4.2); 3.2012 (0.8); 3.1826 (2.3); 3.1666 (3.8); 3.1511 (2.4); 3.0606 (2.8); 2.9520 (9.6); 2.7495 (16.0); 2.7376 (14.6); 2.6877 (1.5); 2.6794 (1.7); 2.6700 (1.6); 2.6654 (1.1); 2.5235 (3.9); 2.5188 (5.7); 2.5101 (84.2); 2.5056 (183.0); 2.5010 (256.0); 2.4963 (179.1); 2.4918 (79.4); 2.4501 (0.8); 2.4270 (0.8); 2.4065 (1.5); 2.3836 (2.0); 2.3654 (1.8); 2.3424 (1.5); 2.3279 (1.6); 2.3003 (0.9); 2.2874 (1.1); 2.2760 (1.4); 2.2631 (1.4); 2.2338 (0.9); 2.2225 (0.9); 2.1583 (1.0); 2.0733 (0.7); 1.8751 (1.6); 1.8569 (2.0); 1.8374 (1.7); 1.8215 (1.2); 1.8104 (1.1); 1.7909 (1.0); 1.7796 (0.8); 1.0969 (5.9); 1.0787 (12.4); 1.0605 (5.5); 0.0081 (1.7); -0.0002 (57.4); -0.0086 (1.5) I.1-269: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.5018 (1.1); 7.4091 (1.5); 7.4045 (0.5); 7.3930 (0.6); 7.3882 (2.2); 7.2648 (1.7); 7.2438 (1.3); 4.6430 (0.6); 4.6040 (0.7); 4.1229 (0.7); 4.0840 (0.6); 3.7497 (0.3); 3.3748 (11.4); 3.1681 (1.3); 2.7710 (16.0); 2.7166 (0.4); 2.7062 (0.4); 2.6791 (0.5); 2.6687 (0.5); 2.5110 (4.2); 2.5066 (9.2); 2.5021 (13.0); 2.4976 (9.5); 2.4931 (4.5); 2.3897 (0.3); 2.3552 (0.5); 2.3330 (0.5); 2.3177 (0.4); 2.2953 (0.4); 2.2917 (0.4); 2.2806 (0.4); 2.2670 (0.3) I.1-270: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5235 (0.5); 7.5202 (0.6); 7.3105 (0.4); 7.2647 (84.8); 7.2614 (108.9); 7.1263 (0.9); 7.1132 (1.9); 7.1012 (3.7); 7.0931 (2.9); 7.0767 (5.6); 7.0705 (4.3); 7.0592 (16.0); 7.0489 (13.5); 7.0393 (4.9); 7.0199 (0.4); 7.0008 (0.4); 6.9974 (0.6); 5.7716 (0.7); 5.5327 (3.5); 5.3018 (1.7); 5.2985 (2.2); 4.8712 (1.1); 4.8405 (6.8); 4.8017 (7.5); 4.3545 (1.4); 4.3160 (1.2); 4.2790 (8.2); 4.2402 (7.1); 4.0405 (0.3); 4.0285 (0.5); 4.0196 (0.6); 4.0102 (0.5); 3.9891 (1.3); 3.9777 (2.3); 3.9687 (3.2); 3.9579 (4.3); 3.9472 (3.3); 3.9367 (2.4); 3.9262 (1.1); 3.2418 (0.4); 2.8976 (0.7); 2.8883 (0.7); 2.8575 (0.9); 2.8482 (0.9); 2.7045 (0.7); 2.6967 (1.7); 2.6870 (3.0); 2.6788 (4.0); 2.6695 (4.1); 2.6606 (3.0); 2.6519 (1.8); 2.6429 (0.7); 2.5719 (4.5); 2.5606 (4.5); 2.5494 (1.6); 2.5351 (6.1); 2.5250 (6.5); 2.5064 (5.2); 2.4855 (4.6); 2.4642 (4.9); 2.4425 (3.7); 2.4283 (3.5); 2.4186 (4.0); 2.4040 (5.1); 2.3880 (1.5); 2.3755 (2.4); 2.3617 (2.4); 2.3254 (1.8); 2.3064 (3.0); 2.2926 (2.3); 2.2867 (2.3); 2.2830 (2.2); 2.2739 (3.4); 2.2687 (2.0); 2.2535 (2.5); 2.2309 (1.3); 2.1439 (6.2); 2.1221 (6.5); 2.1076 (6.1); 2.0859 (5.9); 1.8772 (1.5); 1.8662 (2.6); 1.8537 (2.7); 1.8431 (3.0); 1.8325 (3.2); 1.8213 (2.7); 1.8098 (2.5); 1.7957 (1.4); 1.7767 (0.4); 0.8358 (0.3); 0.8164 (1.1); 0.7959 (3.3); 0.7818 (11.2); 0.7786 (10.4); 0.7671 (9.8); 0.7644 (11.0); 0.7609 (8.0); 0.7496 (3.0); 0.7236 (0.3); 0.5735 (0.3); 0.5480 (2.1); 0.5215 (0.5); 0.5116 (0.5); 0.4807 (2.9); 0.4665 (10.5); 0.4620 (9.6); 0.4574 (9.6); 0.4428 (2.5); 0.0117 (0.9); 0.0034 (31.3); 0.0000 (41.4) I.1-271: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3435 (2.0); 8.3224 (2.0); 7.2816 (0.8); 7.2632 (2.1); 7.2436 (3.1); 7.2403 (2.8); 7.2362 (2.8); 7.2216 (8.3); 7.2155 (8.5); 7.1993 (4.2); 7.1865 (1.6); 7.1818 (1.9); 7.1656 (0.8); 7.1268 (4.0); 7.1071 (7.9); 7.0806 (3.2); 7.0564 (6.0); 7.0363 (3.2); 4.5971 (2.0); 4.5591 (2.4); 4.4465 (0.9); 4.4347 (0.9); 4.4207 (1.0); 4.4143 (1.0); 4.4008 (0.7); 4.3886 (0.6); 3.9902 (1.0); 3.9532 (0.9); 3.8746 (1.9); 3.8365 (1.8); 3.5636 (1.1); 3.5520 (1.1); 3.5320 (0.6); 3.3360 (242.8); 3.1673 (0.7); 3.0881 (1.2); 3.0764 (1.2); 3.0535 (1.6); 3.0416 (1.4); 2.8338 (1.4); 2.8078 (1.4); 2.7993 (1.4); 2.7738 (1.0); 2.6746 (1.1); 2.6700 (1.6); 2.6655 (1.1); 2.5403 (1.5); 2.5234 (4.1); 2.5187 (6.4); 2.5101 (94.9); 2.5055 (203.7); 2.5009 (281.8); 2.4964 (196.3); 2.4918 (88.0); 2.4786 (2.8); 2.4680 (1.8); 2.4556 (1.1); 2.4444 (1.6); 2.4344 (1.3); 2.3323 (1.2); 2.3278 (1.5); 2.3232 (1.1); 2.2707 (16.0); 2.2521 (1.4); 2.2312 (1.6); 2.2100 (1.1); 2.1844 (1.1); 2.1715 (1.3); 2.1606 (1.4); 2.1473 (1.4); 2.1240 (1.4); 2.1011 (1.6); 2.0903 (1.5); 2.0672 (1.3); 2.0588 (0.8); 2.0365 (0.6); 1.8766 (0.7); 1.8522 (0.7); 1.8441 (0.8); 1.8198 (0.7); 1.6454 (0.6); 1.6341 (0.8); 1.6124 (0.8); 1.6027 (0.7); -0.0002 (6.5) I.1-272: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3528 (2.1); 8.3320 (2.2); 7.2819 (1.4); 7.2636 (3.2); 7.2612 (3.2); 7.2511 (1.5); 7.2441 (4.1); 7.2411 (3.4); 7.2368 (2.6); 7.2213 (7.7); 7.2166 (8.9); 7.1999 (5.0); 7.1866 (2.5); 7.1824 (2.1); 7.1695 (1.1); 7.1661 (1.0); 7.1271 (4.1); 7.1072 (8.2); 7.0803 (5.0); 7.0561 (4.8); 7.0357 (2.5); 4.5973 (2.2); 4.5593 (2.5); 4.4706 (0.6); 4.4572 (0.8); 4.4450 (1.0); 4.4330 (0.8); 4.4241 (1.0); 4.4120 (0.7); 4.3986 (0.6); 3.9909 (1.7); 3.9528 (1.6); 3.8720 (1.7); 3.8340 (1.7); 3.6006 (1.5); 3.5897 (1.7); 3.5799 (2.0); 3.5700 (2.1); 3.5596 (2.1); 3.5498 (2.0); 3.5411 (1.9); 3.5300 (1.7); 3.3683 (99.8); 3.1676 (0.9); 3.0881 (1.5); 3.0770 (1.6); 3.0535 (1.9); 3.0428 (1.8); 2.8321 (1.9); 2.8265 (2.0); 2.7990 (2.4); 2.7921 (2.0); 2.7721 (1.8); 2.7665 (1.9); 2.6751 (2.0); 2.6707 (2.2); 2.6661 (2.1); 2.6047 (1.7); 2.5523 (2.1); 2.5408 (2.4); 2.5240 (4.5); 2.5193 (5.9); 2.5105 (48.9); 2.5061 (105.5); 2.5016 (148.6); 2.4971 (117.4); 2.4929 (62.4); 2.4790 (4.2); 2.4681 (2.3); 2.4543 (2.8); 2.4443 (2.9); 2.4341 (1.7); 2.3329 (1.0); 2.3284 (1.3); 2.3238 (1.1); 2.2921 (0.9); 2.2676 (16.0); 2.2507 (1.9); 2.2302 (1.9); 2.2088 (1.2); 2.1841 (1.3); 2.1706 (1.4); 2.1603 (1.6); 2.1463 (1.5); 2.1228 (1.3); 2.1002 (1.4); 2.0895 (1.6); 2.0738 (0.7); 2.0666 (1.5); 2.0573 (1.1); 2.0347 (0.9); 1.8716 (0.5); 1.8511 (0.6); 1.8424 (0.7); 1.8191 (0.6); 1.7616 (0.5); 1.7376 (0.6); 1.7295 (0.6); 1.7054 (0.6); 1.6330 (0.6); 1.6228 (0.6); 1.6110 (0.6); 1.3789 (0.6); 1.3669 (0.6); 1.3562 (0.6); 1.3466 (0.5); -0.0002 (10.1) I.1-273: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1483 (1.9); 7.1279 (7.7); 7.1155 (8.4); 7.1097 (1.4); 7.0947 (1.8); 4.6871 (1.1); 4.6812 (1.1); 4.6494 (1.3); 4.6431 (1.3); 4.6360 (1.1); 4.6211 (2.0); 4.6055 (2.0); 4.5908 (1.0); 4.0424 (2.2); 4.0043 (2.0); 3.7107 (0.6); 3.7002 (1.0); 3.6898 (1.0); 3.6793 (1.0); 3.6687 (0.7); 3.4052 (2.2); 3.3714 (124.8); 3.3330 (1.0); 2.7638 (0.8); 2.7541 (0.9); 2.7429 (0.8); 2.7334 (0.8); 2.7247 (1.1); 2.7151 (1.0); 2.7042 (1.0); 2.6947 (1.0); 2.6714 (0.5); 2.5412 (0.8); 2.5364 (1.2); 2.5320 (1.3); 2.5248 (1.8); 2.5200 (2.5); 2.5114 (32.7); 2.5069 (68.3); 2.5023 (91.6); 2.4977 (63.3); 2.4931 (28.1); 2.4211 (1.3); 2.4160 (0.7); 2.4080 (1.4); 2.3988 (1.7); 2.3923 (0.8); 2.3854 (1.3); 2.3823 (1.4); 2.3740 (1.0); 2.3689 (1.4); 2.3601 (1.1); 2.3467 (1.0); 2.3291 (0.6); 2.2947 (0.6); 2.2914 (0.7); 2.2745 (16.0); 2.2532 (1.0); 2.2143 (0.5); 2.1448 (0.7); 2.1324 (0.6); 2.1266 (0.5); 2.1198 (0.6); 2.1143 (0.8); 2.1078 (0.6); 2.0947 (0.5); 2.0882 (0.6); 1.7223 (0.5); 1.7145 (0.8); 1.7051 (1.2); 1.6969 (1.2); 1.6911 (1.2); 1.6828 (1.4); 1.6730 (1.1); 1.6654 (0.8); 1.6624 (0.8); 1.6580 (0.6); 1.6499 (0.5); 1.0743 (8.5); 1.0722 (8.4); 1.0583 (8.5); 1.0563 (8.2); 0.8325 (12.6); 0.8288 (13.0); 0.8154 (12.2); 0.8118 (12.5); 0.0080 (0.9); -0.0002 (29.8); -0.0085 (0.8) I.1-274: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5186 (0.3); 7.2713 (4.3); 7.2617 (44.5); 7.2599 (59.8); 7.1445 (0.3); 7.1231 (16.0); 5.9312 (0.6); 4.7441 (1.5); 4.7064 (1.7); 4.1310 (1.7); 4.0934 (1.5); 3.9549 (0.6); 3.9453 (0.7); 3.9345 (1.0); 3.9243 (0.7); 3.9138 (0.5); 3.7114 (1.2); 3.7003 (14.3); 3.4938 (0.5); 3.4793 (1.6); 3.4639 (2.2); 3.4485 (1.5); 3.4334 (0.5); 2.5368 (0.4); 2.5269 (1.3); 2.5152 (3.2); 2.5005 (3.6); 2.4920 (2.1); 2.4855 (2.2); 2.4794 (1.4); 2.4520 (0.6); 2.4262 (0.6); 2.4121 (0.7); 2.4017 (0.8); 2.3878 (0.8); 2.3593 (0.4); 2.3447 (0.5); 2.3270 (11.7); 2.2294 (0.6); 2.2160 (0.4); 2.2054 (0.5); 2.1971 (0.6); 2.1773 (0.4); 2.1727 (0.5); 2.1089 (1.1); 2.0874 (1.1); 2.0726 (0.9); 2.0513 (0.9); 1.7948 (0.5); 1.7828 (0.6); 1.7734 (0.6); 1.7596 (0.5); 1.7502 (0.5); 1.7390 (0.3); 1.5615 (2.1); 1.5526 (19.2); 1.5505 (24.4); 0.0102 (2.0); 0.0081 (2.1); 0.0019 (18.8); 0.0000 (25.6) I.1-275: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.6323 (15.5); 7.6269 (16.0); 7.4182 (7.1); 7.4128 (6.6); 7.3974 (8.9); 7.3920 (8.5); 7.2503 (10.9); 7.2294 (8.6); 7.1902 (4.7); 7.0585 (10.3); 6.9268 (5.3); 4.6082 (6.2); 4.5669 (7.6); 4.2451 (7.3); 4.2038 (6.1); 3.8757 (1.4); 3.8659 (2.2); 3.8559 (2.9); 3.8460 (3.2); 3.8343 (3.0); 3.8243 (2.5); 3.8145 (1.3); 3.1693 (1.0); 2.7965 (3.6); 2.7869 (3.8); 2.7570 (4.8); 2.7473 (4.5); 2.6704 (0.6); 2.5280 (4.8); 2.5241 (2.3); 2.5192 (2.3); 2.5105 (34.0); 2.5059 (76.5); 2.5013 (100.6); 2.4966 (70.6); 2.4920 (33.0); 2.4661 (4.1); 2.4595 (0.8); 2.4530 (1.5); 2.4506 (1.4); 2.4447 (1.3); 2.4374 (1.1); 2.4292 (3.5); 2.4110 (2.9); 2.4067 (2.6); 2.3981 (1.1); 2.3897 (1.4); 2.3760 (0.9); 2.3326 (0.8); 2.3273 (2.4); 2.3150 (2.2); 2.3028 (3.7); 2.2909 (3.6); 2.2615 (5.5); 2.2518 (3.7); 2.2409 (2.1); 2.2344 (1.6); 2.2224 (2.9); 2.2169 (1.4); 2.2102 (1.0); 2.2029 (1.6); 2.1980 (1.7); 2.1787 (0.8); 2.0854 (1.1); 2.0721 (1.2); 1.8182 (0.6); 1.7942 (2.4); 1.7829 (1.8); 1.7725 (2.9); 1.7647 (1.5); 1.7605 (1.5); 1.7555 (1.6); 1.7511 (1.6); 1.7405 (1.6); 1.7290 (1.0); -0.0002 (17.4); -0.0085 (0.6) I.1-276: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.7513 (0.8); 8.3582 (1.4); 8.3380 (1.7); 8.3201 (0.5); 7.2799 (1.5); 7.2617 (3.3); 7.2591 (2.6); 7.2494 (1.4); 7.2441 (4.1); 7.2321 (1.2); 7.2146 (6.6); 7.2063 (5.1); 7.1980 (7.6); 7.1944 (7.8); 7.1855 (2.9); 7.1678 (1.0); 7.1598 (1.3); 7.1537 (1.0); 7.1409 (2.0); 7.1343 (1.5); 7.1258 (1.0); 7.1194 (0.9); 7.0800 (2.7); 7.0610 (1.7); 4.7136 (2.0); 4.6747 (2.1); 4.4937 (0.5); 4.4813 (0.7); 4.4684 (0.9); 4.4606 (0.8); 4.4475 (0.7); 4.4355 (0.7); 4.0224 (1.7); 3.9826 (1.8); 3.9401 (0.6); 3.5620 (0.9); 3.3136 (215.0); 3.2630 (0.6); 3.1651 (0.6); 3.0917 (0.9); 3.0792 (1.2); 3.0564 (1.2); 3.0445 (1.3); 2.8333 (1.3); 2.8081 (1.4); 2.7992 (1.2); 2.7737 (1.1); 2.6788 (0.7); 2.6743 (1.6); 2.6697 (2.3); 2.6651 (1.6); 2.6605 (0.8); 2.5958 (1.0); 2.5829 (2.3); 2.5785 (2.4); 2.5639 (2.3); 2.5400 (1.1); 2.5232 (5.2); 2.5185 (8.0); 2.5098 (132.6); 2.5052 (291.5); 2.5006 (408.6); 2.4960 (288.1); 2.4914 (129.1); 2.4737 (2.5); 2.4499 (3.2); 2.4403 (2.2); 2.4002 (0.6); 2.3366 (1.2); 2.3321 (1.9); 2.3275 (2.7); 2.3228 (1.9); 2.2943 (1.0); 2.2715 (1.4); 2.2492 (0.8); 2.2006 (1.0); 2.1899 (1.1); 2.1760 (1.2); 2.1615 (2.1); 2.1478 (0.8); 2.1386 (1.5); 2.1266 (1.7); 2.1042 (1.0); 2.0730 (0.6); 1.8077 (0.6); 1.7850 (0.7); 1.7736 (0.7); 1.7530 (0.6); 1.4179 (0.7); 1.4088 (0.8); 1.1223 (7.0); 1.1035 (16.0); 1.0847 (6.8); 0.1462 (0.6); 0.0080 (5.8); 0.0063 (1.9); 0.0054 (2.3); - 0.0002 (189.8); -0.0060 (1.8); -0.0068 (1.5); -0.0085 (5.3); -0.0506 (0.8); -0.1496 (0.6) I.1-277: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1453 (0.7); 7.1245 (3.7); 7.1170 (2.6); 7.1122 (2.3); 7.0962 (0.5); 4.6622 (0.8); 4.6239 (0.8); 4.0234 (0.8); 3.3765 (0.7); 3.3272 (115.7); 3.1665 (0.6); 2.6745 (0.6); 2.6699 (0.9); 2.6653 (0.6); 2.5549 (0.5); 2.5503 (0.7); 2.5454 (0.9); 2.5402 (0.8); 2.5342 (0.8); 2.5234 (2.5); 2.5187 (3.5); 2.5100 (47.9); 2.5054 (103.6); 2.5008 (145.0); 2.4962 (101.4); 2.4916 (45.3); 2.4715 (0.9); 2.4629 (0.6); 2.3323 (0.9); 2.3276 (1.1); 2.3229 (0.7); 2.2761 (7.4); 2.0270 (16.0); -0.0002 (14.6) I.1-278: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.7174 (1.1); 8.3395 (1.6); 8.3182 (1.5); 7.2541 (1.2); 7.2372 (2.9); 7.2324 (2.4); 7.2198 (7.2); 7.2061 (9.6); 7.2019 (7.3); 7.1945 (3.4); 7.1911 (3.3); 7.1858 (2.8); 7.1659 (1.3); 7.1464 (1.8); 7.1405 (1.7); 7.1311 (1.0); 7.1248 (1.1); 7.0804 (2.5); 7.0625 (1.7); 4.7166 (2.1); 4.6783 (2.2); 4.4073 (0.9); 4.3741 (0.6); 3.9794 (2.0); 3.9397 (1.8); 3.5354 (1.1); 3.3636 (1.2); 3.3131 (528.4); 3.2523 (0.6); 3.1666 (1.2); 3.0775 (1.0); 3.0665 (1.0); 3.0429 (1.4); 3.0312 (1.1); 2.8299 (1.3); 2.8050 (1.3); 2.7963 (1.2); 2.7714 (1.1); 2.6789 (1.7); 2.6743 (3.5); 2.6697 (5.0); 2.6650 (3.5); 2.6605 (1.6); 2.5918 (1.2); 2.5747 (2.8); 2.5640 (1.3); 2.5527 (3.5); 2.5400 (4.9); 2.5232 (13.4); 2.5185 (19.6); 2.5098 (276.2); 2.5052 (600.5); 2.5006 (843.5); 2.4960 (590.3); 2.4914 (260.2); 2.4472 (1.6); 2.4368 (1.6); 2.3981 (0.6); 2.3366 (1.6); 2.3320 (3.4); 2.3275 (5.0); 2.3228 (3.7); 2.3001 (0.9); 2.2799 (0.8); 2.2584 (1.3); 2.2345 (0.7); 2.2018 (0.8); 2.1909 (1.2); 2.1847 (1.5); 2.1769 (1.1); 2.1609 (1.8); 2.1501 (1.5); 2.1265 (1.6); 2.0730 (2.0); 1.8728 (0.8); 1.8530 (0.7); 1.6909 (0.9); 1.1217 (6.9); 1.1030 (16.0); 1.0841 (6.7); 0.1458 (1.1); 0.0080 (10.9); 0.0062 (3.0); 0.0054 (3.4); -0.0002 (419.6); -0.0060 (4.4); -0.0069 (3.8); -0.0085 (12.4); -0.0156 (1.2); -0.0204 (0.7); -0.1496 (1.2) I.1-280: 1H-NMR (400.1 MHz, d6-DMSO): δ= 17.6767 (1.3); 16.6147 (1.9); 16.6008 (1.6); 12.3224 (2.0); 12.2518 (1.4); 11.4451 (1.3); 8.2865 (1.2); 7.3927 (2.5); 7.3808 (5.4); 7.3686 (5.8); 7.3604 (7.0); 7.3461 (6.6); 7.2003 (1.5); 7.1932 (6.2); 7.1709 (12.2); 7.1666 (5.1); 7.1493 (6.2); 7.1445 (5.4); 7.1211 (2.5); 5.1036 (2.0); 5.0764 (3.5); 5.0688 (1.7); 5.0583 (3.4); 5.0413 (1.9); 5.0377 (1.2); 3.9960 (1.2); 3.9788 (1.4); 3.9719 (1.3); 3.6203 (2.0); 3.6157 (1.6); 3.5967 (2.3); 3.5775 (1.5); 3.3804 (3.1); 3.3307 (519.4); 3.2798 (2.6); 3.1668 (4.0); 2.6750 (6.0); 2.6712 (7.1); 2.6660 (5.7); 2.6381 (2.6); 2.6295 (2.8); 2.5980 (3.4); 2.5900 (3.2); 2.5604 (2.9); 2.5562 (5.1); 2.5514 (6.5); 2.5470 (4.3); 2.5242 (17.1); 2.5194 (25.7); 2.5107 (465.4); 2.5062 (1018.1); 2.5017 (1408.0); 2.4971 (1005.3); 2.4927 (461.8); 2.4571 (6.7); 2.4516 (5.8); 2.4472 (4.1); 2.4169 (4.9); 2.3987 (4.5); 2.3825 (1.7); 2.3738 (4.0); 2.3590 (3.7); 2.3380 (8.9); 2.3336 (8.1); 2.3283 (7.7); 2.3242 (5.9); 2.1939 (2.0); 2.1842 (2.2); 2.1703 (4.4); 2.1603 (3.7); 2.1437 (3.0); 2.1286 (3.9); 2.1201 (4.1); 2.1032 (1.3); 2.0854 (1.4); 2.0753 (3.4); 2.0644 (1.8); 2.0545 (2.8); 2.0297 (3.2); 2.0131 (2.4); 1.9892 (1.6); 1.6894 (1.4); 1.6579 (2.6); 1.6513 (2.6); 1.6275 (1.6); 1.5830 (6.7); 1.5652 (6.7); 1.5353 (16.0); 1.5172 (15.6); 1.3476 (1.2); 0.3393 (1.2); 0.1463 (1.7); 0.0084 (8.3) I.1-282: 1H-NMR (400.1 MHz, d6-DMSO): δ= 19.9309 (0.5); 16.9434 (0.6); 16.3191 (0.5); 16.2540 (0.7); 15.0797 (0.6); 12.5949 (0.6); 11.9690 (1.2); 11.9603 (1.3); 11.9296 (0.6); 11.1973 (0.6); 9.2239 (0.5); 8.2723 (1.9); 8.2527 (2.0); 7.3711 (1.6); 7.3506 (3.2); 7.3354 (3.7); 7.3312 (2.6); 7.3153 (2.2); 7.1370 (4.0); 7.1186 (5.2); 7.0899 (2.3); 7.0506 (1.7); 7.0458 (1.4); 7.0288 (2.8); 7.0086 (1.5); 7.0022 (1.4); 4.9424 (0.6); 4.9261 (1.8); 4.9076 (2.6); 4.8897 (2.0); 4.7848 (0.5); 4.7193 (3.3); 4.7055 (3.3); 3.8206 (0.9); 3.8076 (1.4); 3.7859 (1.6); 3.7793 (1.4); 3.5764 (0.6); 3.3556 (1.5); 3.3444 (1.0); 3.3060 (784.9); 3.1750 (0.8); 3.1626 (0.8); 2.6739 (1.9); 2.6689 (2.0); 2.6645 (1.7); 2.5536 (0.6); 2.5230 (3.5); 2.5180 (4.8); 2.5093 (131.4); 2.5047 (290.5); 2.5002 (407.7); 2.4956 (290.0); 2.4910 (133.9); 2.4196 (0.6); 2.4013 (0.6); 2.3432 (1.3); 2.3314 (2.7); 2.3273 (2.8); 2.3217 (2.4); 2.3055 (2.6); 2.2969 (3.0); 2.2930 (2.8); 2.2838 (2.4); 2.2675 (1.0); 2.2553 (3.5); 2.2351 (4.5); 2.2219 (2.2); 2.1980 (2.8); 2.1802 (1.4); 2.1723 (2.0); 2.1639 (1.3); 2.1565 (1.6); 2.1516 (1.2); 2.1353 (1.2); 2.1194 (0.8); 2.1115 (0.5); 2.0709 (1.2); 1.6935 (1.0); 1.6590 (1.4); 1.6431 (1.7); 1.6338 (1.4); 1.6246 (1.1); 1.6088 (0.9); 1.5736 (0.8); 1.5506 (1.4); 1.5356 (1.7); 1.5156 (1.6); 1.5031 (0.9); 1.4952 (0.9); 1.4791 (0.7); 1.3276 (15.8); 1.3101 (16.0); 1.2351 (0.6); 0.1467 (0.6); 0.0078 (2.1) I.1-283: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1442 (2.1); 7.1238 (7.3); 7.1119 (3.4); 7.1044 (4.1); 7.0852 (1.7); 7.0616 (0.8); 4.7118 (0.6); 4.6744 (0.7); 4.6221 (0.6); 4.5910 (0.7); 4.5177 (0.6); 4.4877 (0.7); 4.1884 (0.9); 4.0780 (0.8); 4.0405 (0.7); 3.9924 (0.7); 3.7313 (0.8); 3.6440 (0.8); 3.6195 (0.7); 3.4882 (1.4); 3.3733 (218.5); 3.1679 (2.5); 2.7418 (0.8); 2.6750 (1.6); 2.6702 (2.3); 2.6656 (1.8); 2.5405 (0.8); 2.5236 (5.2); 2.5189 (7.5); 2.5103 (118.5); 2.5057 (260.9); 2.5011 (365.3); 2.4965 (254.0); 2.4919 (113.7); 2.4559 (1.6); 2.4511 (2.0); 2.4465 (1.5); 2.3859 (1.0); 2.3473 (1.0); 2.3325 (1.9); 2.3279 (2.6); 2.3233 (2.0); 2.2749 (16.0); 2.2381 (1.4); 2.0727 (2.1); 1.9136 (1.6); 1.8673 (1.4); 1.8488 (1.7); 1.6495 (0.8); 1.0627 (0.6); -0.0002 (14.8) I.1-284: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.2226 (1.3); 8.4673 (1.8); 8.4522 (3.3); 8.4376 (1.8); 7.9438 (1.0); 7.9228 (1.2); 7.8145 (1.5); 7.7926 (15.1); 7.7881 (5.3); 7.7761 (5.5); 7.7715 (16.0); 7.6553 (1.0); 7.6339 (0.9); 7.4330 (13.6); 7.4118 (12.3); 5.6780 (0.8); 5.6629 (1.4); 5.6391 (2.7); 5.6242 (9.3); 5.6211 (5.0); 5.6158 (3.3); 5.6104 (4.8); 5.6074 (9.7); 5.5926 (3.3); 5.5853 (1.4); 5.5813 (1.9); 5.5772 (1.2); 5.5714 (1.3); 5.5688 (1.8); 5.5540 (0.9); 4.7066 (0.5); 4.6662 (0.6); 4.3367 (11.4); 4.3216 (11.2); 4.2817 (0.6); 4.2423 (0.6); 4.1569 (0.5); 4.1437 (0.5); 3.3412 (37.7); 3.0073 (10.6); 3.0045 (9.4); 2.9997 (5.5); 2.9940 (14.2); 2.9505 (11.6); 2.9368 (9.4); 2.6751 (0.8); 2.6703 (1.2); 2.6387 (0.5); 2.6287 (0.6); 2.5237 (3.7); 2.5188 (5.6); 2.5103 (57.2); 2.5058 (118.6); 2.5012 (161.2); 2.4966 (114.3); 2.4921 (52.3); 2.4672 (0.8); 2.4613 (0.9); 2.4177 (0.6); 2.3938 (0.6); 2.3492 (0.7); 2.3373 (0.7); 2.3326 (1.0); 2.3277 (1.4); 2.3233 (1.0); 2.3092 (0.7); 2.2961 (0.5); 2.2870 (0.6); 2.2825 (0.5); -0.0002 (6.6) I.1-285: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8174 (0.6); 7.7987 (0.5); 7.3539 (0.6); 7.3317 (0.6); 7.1883 (0.6); 7.1846 (0.7); 7.1722 (0.7); 7.0709 (0.6); 7.0548 (0.9); 4.7290 (1.0); 4.6893 (1.2); 4.2374 (1.3); 4.1974 (1.1); 3.8137 (0.6); 3.8078 (0.5); 3.7974 (1.3); 3.7873 (0.9); 3.7785 (1.2); 3.7669 (0.6); 3.7624 (0.6); 3.3212 (46.0); 2.5232 (0.5); 2.5185 (0.8); 2.5098 (16.1); 2.5053 (35.6); 2.5007 (49.9); 2.4961 (35.5); 2.4916 (16.4); 2.4664 (1.1); 2.4543 (1.1); 2.4317 (1.2); 2.4197 (1.1); 2.3571 (0.8); 2.3372 (0.8); 2.3149 (0.6); 2.2867 (0.6); 2.2733 (0.7); 2.2628 (0.8); 2.2493 (0.8); 2.1643 (1.2); 2.1435 (1.3); 2.1295 (1.1); 2.1086 (1.2); 2.1026 (0.5); 2.0950 (0.7); 2.0710 (0.5); 1.7451 (0.5); 1.0207 (16.0); 1.0042 (15.9); -0.0002 (11.0) I.1-286: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3796 (0.9); 7.3589 (2.2); 7.3373 (2.2); 7.3163 (1.1); 7.2081 (1.1); 7.1992 (1.0); 7.1918 (2.0); 7.1883 (2.2); 7.1759 (2.2); 7.1718 (1.7); 7.1679 (1.6); 7.1555 (1.2); 7.0969 (1.2); 7.0810 (2.2); 7.0612 (1.6); 7.0452 (0.7); 5.0694 (1.0); 5.0605 (1.9); 5.0476 (1.1); 4.7892 (1.5); 4.7757 (1.2); 4.7526 (3.0); 4.7392 (1.2); 4.7151 (2.0); 4.3019 (0.7); 4.2884 (1.6); 4.2643 (2.0); 4.2487 (1.4); 4.2375 (1.0); 4.2240 (1.7); 4.1958 (0.9); 4.1811 (0.7); 4.1674 (1.5); 4.1500 (2.2); 4.1354 (1.5); 4.1327 (2.0); 4.1301 (2.4); 4.1230 (2.0); 4.1177 (1.6); 4.1123 (4.3); 4.1099 (3.6); 4.1052 (5.6); 4.0945 (3.7); 4.0921 (3.4); 4.0874 (5.6); 4.0766 (1.2); 4.0697 (1.8); 3.8576 (0.9); 3.8485 (1.0); 3.8383 (0.9); 3.8264 (0.9); 3.8153 (0.9); 3.8046 (0.9); 3.7932 (0.9); 3.7838 (1.2); 3.7744 (1.0); 3.7392 (1.0); 3.7061 (0.6); 3.3521 (0.9); 3.3172 (207.4); 3.2934 (5.9); 3.0627 (0.5); 3.0443 (0.6); 3.0371 (0.8); 3.0305 (0.8); 3.0197 (0.9); 3.0124 (0.9); 2.9876 (0.6); 2.9416 (6.9); 2.8973 (1.1); 2.8866 (0.9); 2.8652 (0.6); 2.8568 (1.4); 2.8461 (1.1); 2.8392 (0.9); 2.8289 (0.9); 2.7991 (1.1); 2.7894 (1.0); 2.6748 (0.8); 2.6701 (1.2); 2.6655 (0.9); 2.5986 (1.2); 2.5908 (1.5); 2.5766 (1.8); 2.5588 (1.2); 2.5451 (0.8); 2.5404 (1.4); 2.5361 (1.3); 2.5236 (2.0); 2.5189 (3.7); 2.5102 (68.7); 2.5056 (152.9); 2.5010 (215.3); 2.4964 (151.0); 2.4918 (68.4); 2.4813 (3.5); 2.4730 (2.5); 2.4684 (2.0); 2.4633 (1.6); 2.4509 (0.7); 2.4409 (1.8); 2.4314 (1.4); 2.4183 (1.3); 2.4001 (2.0); 2.3778 (1.2); 2.3572 (0.8); 2.3374 (1.0); 2.3325 (1.3); 2.3278 (1.5); 2.3231 (1.3); 2.3188 (1.1); 2.3012 (0.7); 2.2777 (1.3); 2.2696 (0.9); 2.2652 (1.1); 2.2574 (1.0); 2.2533 (1.7); 2.2450 (1.4); 2.2412 (1.8); 2.2333 (1.3); 2.2119 (1.6); 2.2046 (1.9); 2.1925 (1.5); 2.1798 (0.8); 2.1708 (1.4); 2.1606 (1.4); 2.1471 (1.5); 2.1402 (1.6); 2.1158 (1.4); 2.0963 (1.5); 2.0734 (1.0); 2.0620 (1.3); 1.7125 (0.6); 1.7002 (0.6); 1.6875 (1.1); 1.6820 (1.0); 1.6576 (1.7); 1.6468 (2.1); 1.6148 (2.6); 1.6051 (2.5); 1.5825 (1.9); 1.5442 (0.8); 1.5292 (0.9); 1.5100 (1.1); 1.5010 (0.8); 1.4936 (0.8); 1.4776 (0.7); 1.4685 (0.5); 1.3801 (0.5); 1.3479 (0.6); 1.2847 (0.5); 1.2518 (0.9); 1.2432 (1.4); 1.2254 (2.3); 1.2148 (4.8); 1.2076 (1.8); 1.1970 (9.6); 1.1944 (8.8); 1.1889 (4.5); 1.1821 (8.5); 1.1793 (6.2); 1.1766 (16.0); 1.1712 (7.7); 1.1644 (15.5); 1.1588 (7.6); 1.1534 (3.7); 1.1466 (6.8); -0.0002 (2.2) I.1-287: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1873 (0.5); 7.1808 (2.0); 7.1728 (7.6); 7.1681 (4.3); 7.1632 (1.2); 7.1559 (1.7); 7.1506 (0.7); 7.1436 (1.2); 7.1094 (1.5); 7.0968 (1.2); 7.0909 (0.6); 4.7105 (1.7); 4.6711 (2.0); 4.0769 (1.8); 4.0375 (1.6); 3.9636 (1.1); 3.6728 (0.7); 3.6629 (0.7); 3.6590 (0.6); 3.6528 (0.8); 3.6496 (0.9); 3.6437 (0.6); 3.6394 (0.8); 3.6297 (0.8); 3.5374 (1.7); 3.5051 (1.3); 3.1673 (9.4); 2.6773 (1.2); 2.6681 (1.3); 2.6377 (1.5); 2.6284 (1.5); 2.5233 (0.5); 2.5186 (0.8); 2.5100 (11.6); 2.5054 (25.4); 2.5008 (35.5); 2.4962 (24.9); 2.4916 (11.3); 2.4555 (0.6); 2.4514 (0.7); 2.4318 (0.9); 2.4113 (0.9); 2.3898 (0.6); 2.3573 (1.7); 2.3339 (1.7); 2.3178 (1.5); 2.3049 (0.7); 2.2941 (1.9); 2.2803 (1.1); 2.2687 (1.0); 2.2387 (0.8); 2.2242 (16.0); 2.2087 (0.6); 2.1895 (0.8); 2.1777 (0.6); 2.1650 (0.5); 2.1579 (0.8); 2.1334 (0.6); 1.7506 (0.6); 1.7289 (0.7); 1.7194 (0.7); -0.0002 (8.4) I.1-288: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.4475 (0.8); 8.1332 (1.0); 8.1120 (1.3); 8.0881 (0.9); 7.2016 (1.9); 7.1811 (3.9); 7.1444 (3.4); 7.1241 (1.7); 4.6852 (1.0); 4.6455 (1.1); 4.3392 (0.6); 4.3224 (0.6); 4.1931 (0.6); 3.9904 (1.2); 3.9516 (1.0); 3.6687 (0.5); 3.3215 (161.4); 3.1672 (7.5); 2.8755 (0.7); 2.8584 (1.0); 2.8416 (0.8); 2.6789 (1.3); 2.6743 (3.0); 2.6697 (4.2); 2.6651 (2.8); 2.6604 (1.2); 2.5232 (12.6); 2.5184 (18.3); 2.5098 (240.9); 2.5052 (517.3); 2.5006 (719.5); 2.4960 (504.1); 2.4914 (224.8); 2.4655 (0.7); 2.4499 (1.4); 2.4454 (1.4); 2.3367 (1.8); 2.3319 (3.3); 2.3274 (4.6); 2.3227 (3.8); 2.2996 (0.7); 2.2370 (0.7); 2.2235 (0.7); 2.1886 (0.9); 2.1640 (0.7); 2.1545 (0.7); 2.1305 (0.6); 2.0731 (4.5); 1.9650 (0.6); 1.7248 (0.5); 1.5995 (0.8); 1.5825 (0.8); 1.5650 (0.9); 1.5311 (0.7); 1.5017 (0.9); 1.4885 (0.9); 1.4658 (0.8); 1.4320 (1.3); 1.4141 (1.4); 1.1936 (16.0); 1.1763 (15.8); 0.8866 (5.4); 0.8798 (5.2); 0.8704 (5.8); 0.8632 (5.7); 0.8467 (1.3); 0.8333 (4.8); 0.8173 (8.7); 0.8015 (4.7); 0.7796 (1.0); 0.1460 (0.8); 0.0080 (7.6); -0.0002 (278.8); -0.0085 (8.7); -0.1497 (1.0) I.1-290: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4076 (1.4); 7.4012 (11.5); 7.3965 (4.0); 7.3850 (4.6); 7.3801 (16.0); 7.3739 (2.1); 7.2602 (12.3); 7.2390 (9.2); 7.2038 (3.0); 7.0722 (6.5); 6.9405 (3.3); 4.6044 (4.3); 4.5654 (5.0); 4.1446 (5.0); 4.1056 (4.4); 3.8098 (1.1); 3.7993 (1.8); 3.7887 (2.4); 3.7782 (2.7); 3.7682 (2.5); 3.7577 (2.0); 3.7474 (1.2); 3.7311 (0.6); 3.7202 (0.6); 3.6832 (0.5); 3.5964 (0.7); 3.5503 (2.5); 3.1697 (0.5); 2.8085 (2.6); 2.7981 (2.7); 2.7689 (3.3); 2.7586 (3.2); 2.5240 (0.5); 2.5192 (0.9); 2.5106 (19.6); 2.5061 (42.3); 2.5015 (58.4); 2.4969 (42.5); 2.4923 (20.8); 2.4670 (0.7); 2.4529 (3.8); 2.4474 (1.3); 2.4426 (1.4); 2.4309 (3.3); 2.4239 (1.7); 2.4136 (3.1); 2.4001 (2.6); 2.3914 (2.8); 2.3818 (2.4); 2.3771 (2.1); 2.3585 (1.9); 2.3281 (0.5); 2.3008 (1.6); 2.2875 (2.0); 2.2765 (2.5); 2.2632 (2.6); 2.2461 (0.9); 2.2346 (1.5); 2.2219 (1.6); 2.1901 (1.0); 2.1712 (1.6); 2.1664 (1.0); 2.1587 (1.3); 2.1523 (1.2); 2.1469 (1.4); 2.1398 (1.9); 2.1347 (1.2); 2.1282 (0.9); 2.1204 (1.2); 2.1153 (1.4); 2.0962 (0.7); 1.7316 (0.8); 1.7197 (1.3); 1.7084 (1.7); 1.6978 (1.6); 1.6880 (1.6); 1.6766 (1.6); 1.6652 (1.1); 1.6525 (0.7); -0.0002 (18.5); -0.0085 (0.8) I.1-291: 1H-NMR (400.1 MHz, CDCl3): δ= 7.2620 (21.2); 7.2599 (23.3); 7.1516 (0.6); 7.1301 (2.8); 7.1098 (6.7); 7.0917 (2.5); 7.0840 (6.6); 7.0640 (2.6); 5.2993 (2.5); 5.2973 (2.7); 4.8264 (2.0); 4.7888 (2.2); 4.6068 (0.3); 4.0072 (2.2); 3.9694 (2.1); 3.9557 (0.7); 3.9460 (1.1); 3.9360 (1.2); 3.9259 (1.1); 3.9161 (0.7); 3.9060 (0.4); 3.2797 (0.4); 3.2626 (0.3); 2.8558 (0.6); 2.8306 (0.6); 2.8164 (2.0); 2.7968 (1.2); 2.7856 (1.2); 2.7567 (1.5); 2.7458 (1.5); 2.5760 (1.8); 2.5564 (2.1); 2.5353 (2.0); 2.5154 (1.9); 2.4901 (0.9); 2.4784 (0.9); 2.4667 (1.1); 2.4542 (1.2); 2.4421 (1.2); 2.4234 (0.4); 2.4107 (0.6); 2.3988 (0.5); 2.3339 (1.2); 2.3176 (16.0); 2.2898 (0.6); 2.2680 (0.8); 2.2564 (0.6); 2.2454 (0.8); 2.2353 (0.9); 2.2245 (0.4); 2.2121 (0.8); 1.8761 (0.4); 1.8654 (0.7); 1.8539 (0.7); 1.8426 (0.9); 1.8322 (0.9); 1.8212 (0.6); 1.8095 (0.6); 1.7988 (0.4); 1.2594 (0.3); 1.1924 (0.5); 1.1730 (0.9); 1.1553 (0.4); 0.0020 (5.5) I.1-292: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8237 (3.9); 7.3694 (0.8); 7.3653 (0.8); 7.3494 (0.6); 7.3435 (0.8); 7.1987 (0.8); 7.1952 (0.9); 7.1862 (0.8); 7.1829 (0.9); 7.1787 (0.6); 7.1749 (0.6); 7.1069 (0.7); 7.0906 (1.0); 7.0716 (0.6); 4.7754 (1.1); 4.7358 (1.3); 4.2921 (1.6); 4.2524 (1.5); 4.0350 (0.7); 3.9146 (0.6); 3.9045 (0.9); 3.8936 (1.1); 3.8843 (1.2); 3.8731 (1.0); 3.8630 (0.8); 3.5986 (16.0); 3.1667 (0.7); 2.8870 (0.6); 2.8770 (0.6); 2.8495 (0.7); 2.8398 (0.7); 2.7718 (0.5); 2.5541 (0.8); 2.5310 (1.0); 2.5236 (1.6); 2.5188 (2.6); 2.5102 (27.6); 2.5057 (58.6); 2.5011 (81.0); 2.4965 (57.0); 2.4919 (25.9); 2.4689 (0.6); 2.4270 (1.0); 2.4082 (0.9); 2.4043 (0.8); 2.3867 (0.6); 2.3279 (1.1); 2.3151 (0.7); 2.3035 (1.0); 2.2909 (1.0); 2.2618 (0.7); 2.2515 (1.1); 2.2347 (0.7); 2.2227 (0.6); 2.2038 (0.8); 2.1793 (0.5); 1.8635 (0.5); 1.8521 (0.6); 1.8414 (0.6); 1.8340 (0.6); 0.0080 (1.1); -0.0002 (35.3); -0.0085 (1.0) I.1-293: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.4987 (1.2); 8.2519 (1.7); 8.2321 (1.6); 7.2274 (1.6); 7.2231 (2.1); 7.2129 (4.3); 7.2094 (6.0); 7.1972 (0.8); 7.1738 (1.0); 7.1677 (0.9); 7.1550 (2.0); 7.1479 (2.0); 7.1411 (1.3); 7.1268 (2.7); 7.1091 (0.9); 4.7638 (2.3); 4.7248 (2.5); 4.1909 (0.6); 4.1707 (1.0); 4.1548 (1.1); 4.1333 (0.7); 4.0633 (2.1); 4.0242 (1.9); 3.6789 (0.6); 3.6562 (1.0); 3.6338 (0.6); 3.3120 (147.6); 2.6790 (0.7); 2.6744 (1.4); 2.6697 (2.0); 2.6651 (1.5); 2.6605 (0.6); 2.6292 (1.0); 2.6104 (2.8); 2.6062 (2.7); 2.5916 (2.7); 2.5877 (2.8); 2.5717 (2.1); 2.5616 (1.4); 2.5489 (0.8); 2.5399 (2.5); 2.5378 (2.4); 2.5233 (6.1); 2.5185 (8.6); 2.5098 (112.3); 2.5053 (243.0); 2.5006 (338.8); 2.4960 (236.7); 2.4914 (104.2); 2.4700 (0.7); 2.4504 (0.6); 2.4458 (0.6); 2.4376 (0.7); 2.4145 (1.0); 2.3955 (0.9); 2.3732 (1.4); 2.3509 (0.8); 2.3369 (0.7); 2.3321 (1.4); 2.3274 (2.0); 2.3228 (1.4); 2.3181 (0.7); 2.2897 (0.8); 2.2796 (1.0); 2.2655 (1.2); 2.2553 (1.1); 2.2480 (0.8); 2.2383 (1.9); 2.2237 (0.7); 2.2148 (1.9); 2.2045 (1.4); 2.1808 (1.2); 2.0731 (0.6); 2.0430 (0.7); 2.0316 (0.6); 2.0203 (0.7); 2.0094 (0.9); 1.9888 (0.8); 1.8419 (0.6); 1.8329 (0.5); 1.8195 (0.9); 1.8097 (0.9); 1.6112 (0.6); 1.5952 (0.8); 1.5795 (0.7); 1.5058 (1.5); 1.4987 (1.6); 1.4929 (1.3); 1.4833 (2.7); 1.4693 (1.2); 1.4621 (1.2); 1.1437 (6.9); 1.1250 (16.0); 1.1061 (6.6); 0.8940 (9.8); 0.8776 (9.5); 0.8266 (9.9); 0.8104 (9.7); 0.1459 (0.5); 0.0118 (0.5); 0.0080 (5.2); 0.0063 (1.5); 0.0055 (1.8); 0.0047 (2.1); -0.0002 (181.9); -0.0051 (2.5); -0.0060 (1.9); -0.0068 (1.7); -0.0085 (5.3); -0.0107 (1.0); -0.0115 (0.8); -0.0140 (0.5); -0.1497 (0.6) I.1-294: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3499 (1.7); 8.3286 (1.7); 7.2815 (1.7); 7.2634 (4.1); 7.2607 (3.0); 7.2509 (1.5); 7.2457 (4.9); 7.2175 (6.6); 7.2003 (3.8); 7.1866 (2.4); 7.1691 (0.9); 7.1272 (3.2); 7.1072 (7.0); 7.0806 (7.1); 7.0600 (3.1); 7.0365 (0.5); 4.6001 (1.9); 4.5618 (2.3); 4.4842 (0.6); 4.4731 (0.8); 4.4594 (1.1); 4.4517 (0.9); 4.4383 (0.8); 4.4276 (0.8); 3.9908 (2.2); 3.9529 (1.9); 3.5914 (1.0); 3.5805 (1.0); 3.3813 (10.8); 3.1637 (1.8); 3.0918 (1.1); 3.0791 (1.2); 3.0563 (1.4); 3.0453 (1.3); 2.8284 (1.4); 2.8027 (1.5); 2.7936 (1.2); 2.7679 (1.0); 2.6744 (1.2); 2.6697 (1.6); 2.6651 (1.2); 2.5378 (1.3); 2.5333 (2.5); 2.5232 (5.3); 2.5185 (6.9); 2.5098 (94.1); 2.5052 (204.3); 2.5006 (283.4); 2.4960 (195.9); 2.4914 (86.0); 2.4658 (0.8); 2.4563 (1.7); 2.4443 (1.7); 2.3320 (1.2); 2.3274 (1.5); 2.3227 (1.1); 2.2670 (16.0); 2.2497 (1.2); 2.2304 (1.2); 2.2072 (0.9); 2.1834 (1.1); 2.1701 (1.2); 2.1595 (1.3); 2.1455 (1.2); 2.1284 (0.7); 2.1177 (0.7); 2.0931 (1.6); 2.0699 (1.4); 2.0585 (1.3); 2.0361 (1.2); 1.7645 (0.7); 1.7403 (0.8); 1.7322 (0.9); 1.7085 (0.8); 1.3834 (0.8); 1.3738 (0.7); 1.3506 (0.6); 0.0328 (0.6); 0.0080 (2.8); 0.0055 (1.2); 0.0047 (1.3); 0.0023 (4.2); - 0.0002 (91.0); -0.0027 (4.6); -0.0052 (1.0); -0.0068 (0.7); -0.0085 (2.4) I.1-295: 1H-NMR (400.0 MHz, d6-DMSO): δ= 11.8188 (0.8); 7.1858 (5.3); 7.1754 (8.0); 7.1478 (1.2); 7.0934 (1.2); 7.0862 (0.9); 7.0722 (0.9); 4.7125 (1.1); 4.6892 (0.8); 4.6726 (1.0); 4.6494 (0.9); 4.0782 (1.2); 4.0550 (1.5); 4.0385 (1.4); 4.0151 (1.5); 3.8680 (2.2); 3.7796 (2.2); 3.7433 (2.0); 3.7328 (2.0); 3.6115 (1.0); 3.5938 (1.2); 3.5682 (1.1); 3.5501 (0.9); 3.4235 (0.5); 3.2303 (3.3); 3.1896 (10.3); 3.1783 (2.4); 3.1672 (2.2); 3.1479 (1.5); 3.1299 (1.3); 3.1086 (1.3); 3.0868 (1.1); 3.0423 (0.9); 3.0278 (1.7); 3.0034 (1.0); 2.9899 (0.8); 2.9558 (0.8); 2.7659 (6.0); 2.7539 (5.7); 2.7268 (0.7); 2.7164 (0.7); 2.6886 (0.9); 2.6786 (1.0); 2.6745 (1.3); 2.6699 (1.6); 2.6653 (1.1); 2.5233 (2.9); 2.5186 (4.7); 2.5099 (77.6); 2.5053 (170.7); 2.5007 (240.2); 2.4961 (170.6); 2.4916 (78.3); 2.4508 (1.4); 2.4461 (1.4); 2.4274 (1.5); 2.4050 (1.3); 2.3956 (1.1); 2.3894 (1.1); 2.3673 (0.9); 2.3321 (1.6); 2.3274 (2.2); 2.3231 (2.0); 2.3125 (1.4); 2.2994 (1.6); 2.2886 (1.4); 2.2474 (3.0); 2.2305 (16.0); 2.1951 (0.9); 2.1837 (0.8); 2.1710 (0.9); 2.1499 (0.6); 2.0731 (0.5); 1.8163 (0.7); 1.7968 (0.9); 1.7775 (0.8); 1.7607 (0.8); 1.7509 (0.7); 1.7372 (0.7); 1.7283 (0.6); 1.7065 (0.5); 1.1869 (1.4); 1.1756 (1.5); 1.1325 (0.7); 1.0641 (2.4); 1.0461 (5.3); 1.0281 (2.4); 0.0080 (1.2); -0.0002 (43.6); -0.0085 (1.4) I.1-296: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5204 (1.0); 7.2615 (178.9); 7.2514 (2.9); 7.2467 (2.4); 7.2382 (1.8); 7.2328 (4.2); 7.2278 (3.5); 7.2130 (4.7); 7.2081 (3.1); 7.1994 (2.4); 7.1946 (3.0); 7.1900 (3.0); 7.1854 (2.8); 7.1710 (6.9); 7.1665 (6.2); 7.1522 (4.7); 7.1476 (3.8); 7.1180 (1.4); 7.1022 (7.5); 7.0995 (8.0); 7.0932 (5.0); 7.0837 (10.5); 7.0810 (11.6); 7.0677 (6.4); 7.0622 (5.3); 7.0490 (15.2); 7.0426 (11.4); 7.0384 (8.2); 7.0337 (16.0); 7.0254 (10.9); 7.0148 (1.5); 7.0062 (4.7); 6.9976 (1.3); 5.4657 (3.0); 4.8462 (6.0); 4.8429 (6.1); 4.8075 (6.8); 4.8041 (6.9); 4.2303 (8.8); 4.1916 (7.7); 3.9338 (1.4); 3.9230 (2.9); 3.9120 (3.7); 3.9016 (4.0); 3.8918 (3.6); 3.8809 (3.0); 3.8699 (1.4); 3.5661 (0.5); 3.5490 (1.3); 3.5326 (3.5); 3.5156 (8.7); 3.4996 (12.2); 3.4835 (9.0); 3.4671 (3.5); 3.4499 (1.4); 3.4337 (0.5); 2.8632 (8.2); 2.8462 (15.7); 2.8292 (7.4); 2.5900 (5.8); 2.5792 (5.8); 2.5539 (6.8); 2.5431 (6.7); 2.5146 (1.3); 2.4955 (1.7); 2.4910 (1.6); 2.4715 (4.6); 2.4524 (4.0); 2.4483 (4.0); 2.4292 (3.9); 2.4132 (4.1); 2.3986 (4.6); 2.3890 (5.5); 2.3746 (5.6); 2.3559 (1.6); 2.3460 (2.5); 2.3318 (2.5); 2.2578 (2.1); 2.2386 (3.4); 2.2340 (1.9); 2.2250 (2.5); 2.2196 (2.1); 2.2146 (2.8); 2.2060 (3.9); 2.2010 (2.3); 2.1957 (1.6); 2.1867 (2.2); 2.1818 (3.0); 2.1626 (1.4); 2.1191 (7.2); 2.0965 (7.1); 2.0831 (6.3); 2.0604 (6.2); 1.8139 (2.2); 1.7998 (2.7); 1.7893 (3.4); 1.7796 (3.3); 1.7662 (3.4); 1.7560 (3.2); 1.7460 (2.8); 1.7317 (2.7); 0.0078 (1.5); -0.0002 (46.8); -0.0084 (1.6) I.1-298: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3558 (0.8); 7.3347 (0.8); 7.1868 (0.8); 7.1740 (0.8); 7.1701 (0.7); 7.1663 (0.5); 7.0966 (0.6); 7.0806 (0.8); 4.7607 (0.9); 4.7213 (1.0); 4.7000 (0.5); 4.2677 (1.1); 4.2286 (1.0); 4.2047 (2.5); 4.1741 (0.5); 4.0381 (3.8); 4.0344 (3.7); 3.8308 (0.6); 3.8210 (0.7); 3.8112 (0.7); 3.8017 (0.6); 3.6734 (7.7); 3.6200 (16.0); 3.4115 (14.4); 3.1660 (1.4); 2.9682 (14.8); 2.8500 (0.6); 2.8396 (0.6); 2.8092 (0.9); 2.7991 (0.8); 2.7689 (5.6); 2.6743 (1.0); 2.6699 (1.2); 2.6652 (0.8); 2.5695 (1.0); 2.5554 (0.6); 2.5507 (0.8); 2.5469 (1.2); 2.5401 (0.8); 2.5286 (1.8); 2.5233 (3.2); 2.5186 (4.7); 2.5099 (61.2); 2.5053 (131.9); 2.5007 (182.5); 2.4961 (127.8); 2.4916 (57.4); 2.4327 (0.7); 2.4087 (0.8); 2.3961 (0.5); 2.3322 (0.9); 2.3275 (1.2); 2.3229 (0.8); 2.2562 (0.5); 2.2432 (0.8); 2.2316 (0.8); 2.2019 (0.6); 2.1948 (1.2); 2.1792 (0.6); 2.1479 (0.7); 0.0080 (2.4); -0.0002 (81.5); -0.0085 (2.4) I.1-299: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.6319 (0.3); 3.3264 (16.0); 2.7602 (3.9); 2.5096 (2.8); 2.5051 (6.0); 2.5005 (8.5); 2.4959 (6.2); 2.4913 (3.0) I.1-301: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2611 (68.1); 7.2065 (0.8); 7.2018 (0.7); 7.1855 (1.6); 7.1809 (0.6); 7.1692 (0.7); 7.1646 (1.0); 7.1483 (0.5); 7.1125 (25.7); 6.8810 (2.0); 6.8614 (2.6); 6.8413 (1.7); 5.3513 (0.6); 4.6990 (1.8); 4.6615 (2.1); 4.1199 (1.9); 4.0824 (1.6); 3.9310 (0.7); 3.9202 (0.8); 3.9098 (1.0); 3.9001 (0.8); 3.8893 (0.7); 3.4923 (0.8); 3.4757 (1.2); 3.4592 (1.1); 3.4222 (1.0); 3.4067 (1.1); 3.3899 (0.7); 2.8688 (1.2); 2.8545 (2.2); 2.8521 (2.2); 2.8380 (1.0); 2.8353 (1.0); 2.5024 (1.3); 2.4912 (1.5); 2.4724 (1.0); 2.4662 (1.5); 2.4548 (2.1); 2.4305 (0.7); 2.4127 (0.9); 2.3984 (1.0); 2.3884 (1.1); 2.3743 (1.2); 2.3456 (0.6); 2.3314 (0.7); 2.3213 (16.0); 2.1863 (0.7); 2.1730 (0.5); 2.1621 (0.7); 2.1537 (0.8); 2.1488 (0.5); 2.1342 (0.5); 2.1293 (0.7); 2.0619 (1.6); 2.0400 (1.6); 2.0257 (1.4); 2.0038 (1.4); 1.7392 (0.5); 1.7286 (0.7); 1.7188 (0.6); 1.7057 (0.6); 1.6954 (0.6); -0.0002 (18.6); -0.0085 (0.6) I.1-302: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0108 (1.0); 8.0010 (1.0); 7.2249 (1.5); 7.2213 (1.7); 7.2130 (2.7); 7.2099 (4.1); 7.2070 (6.2); 7.1946 (0.7); 7.1765 (1.1); 7.1697 (1.0); 7.1576 (1.6); 7.1503 (1.6); 7.1432 (0.9); 7.1359 (1.0); 7.1000 (2.3); 7.0819 (1.4); 4.7470 (2.1); 4.7078 (2.4); 4.0548 (2.1); 4.0155 (1.9); 3.7070 (0.6); 3.6971 (0.9); 3.6863 (1.1); 3.6757 (0.9); 3.6658 (0.5); 3.5009 (5.9); 2.6237 (0.9); 2.6046 (3.0); 2.5942 (1.0); 2.5859 (3.7); 2.5762 (1.5); 2.5665 (2.2); 2.5483 (0.9); 2.5457 (0.7); 2.5402 (0.7); 2.5234 (1.0); 2.5187 (1.5); 2.5100 (23.2); 2.5055 (50.9); 2.5008 (71.4); 2.4962 (49.7); 2.4916 (22.1); 2.4379 (1.3); 2.4269 (1.3); 2.4029 (1.6); 2.3916 (1.9); 2.3685 (0.9); 2.3473 (1.4); 2.3243 (0.9); 2.2847 (0.8); 2.2734 (1.0); 2.2603 (1.2); 2.2493 (1.2); 2.2426 (0.6); 2.2316 (0.6); 2.2183 (0.6); 2.2074 (0.6); 2.1282 (1.7); 2.1060 (1.8); 2.0932 (1.5); 2.0819 (0.8); 2.0710 (1.9); 2.0584 (0.7); 2.0498 (0.9); 2.0264 (0.7); 1.7374 (0.6); 1.7285 (0.5); 1.7247 (0.5); 1.7158 (0.9); 1.7052 (0.9); 1.1446 (6.8); 1.1259 (16.0); 1.1070 (6.7); 0.6058 (0.9); 0.5936 (2.7); 0.5883 (3.6); 0.5759 (3.4); 0.5704 (3.0); 0.5584 (1.2); 0.3497 (1.3); 0.3397 (3.2); 0.3334 (2.8); 0.3284 (2.7); 0.3234 (2.8); 0.3115 (1.1); -0.0002 (5.5) I.1-303: 1H-NMR (400.0 MHz, d6-DMSO): δ= 11.8166 (10.6); 8.0474 (2.6); 7.3838 (2.8); 7.3668 (5.4); 7.3424 (5.8); 7.3215 (3.5); 7.2101 (3.3); 7.1938 (5.9); 7.1782 (5.8); 7.1616 (3.6); 7.0731 (5.9); 7.0571 (7.6); 7.0409 (5.2); 7.0210 (2.4); 4.7204 (8.1); 4.6804 (9.2); 4.2464 (9.6); 4.2071 (8.5); 3.8462 (3.6); 3.8357 (4.9); 3.8259 (5.5); 3.8153 (4.6); 3.4014 (5.1); 3.3446 (566.1); 3.2334 (18.4); 3.2120 (111.6); 3.1658 (16.0); 2.7482 (7.1); 2.7376 (6.2); 2.7098 (7.4); 2.6993 (7.2); 2.6744 (15.0); 2.6698 (20.9); 2.6651 (14.7); 2.5623 (7.1); 2.5573 (5.4); 2.5232 (52.8); 2.5185 (81.7); 2.5098 (1173.9); 2.5053 (2552.9); 2.5007 (3561.7); 2.4961 (2494.2); 2.4915 (1123.6); 2.4606 (20.4); 2.4561 (23.2); 2.4514 (20.1); 2.4467 (9.1); 2.4375 (5.1); 2.4156 (10.0); 2.3988 (13.9); 2.3777 (12.1); 2.3564 (6.2); 2.3368 (8.4); 2.3322 (16.6); 2.3274 (22.3); 2.3229 (16.4); 2.3184 (8.5); 2.3038 (6.0); 2.2920 (5.8); 2.2800 (7.4); 2.2676 (7.2); 2.2381 (4.8); 2.2236 (5.9); 2.2047 (6.5); 2.1934 (4.4); 2.1741 (5.6); 2.1503 (4.3); 2.0732 (6.3); 1.7786 (3.5); 1.7677 (3.7); 1.7488 (4.5); 1.7241 (2.8); 1.1327 (2.5); 0.1461 (5.4); 0.0080 (44.0); -0.0002 (1593.3); -0.0086 (48.3); -0.0496 (8.1); -0.1495 (5.3) I.1-304: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3794 (0.9); 7.3592 (1.9); 7.3374 (2.0); 7.3160 (0.9); 7.2080 (1.0); 7.1881 (2.0); 7.1756 (1.9); 7.1557 (1.0); 7.0970 (1.2); 7.0810 (1.8); 7.0623 (1.4); 5.0609 (1.7); 4.7885 (1.4); 4.7758 (1.1); 4.7522 (2.6); 4.7150 (1.7); 4.2886 (1.4); 4.2643 (1.8); 4.2493 (1.2); 4.2381 (0.8); 4.2230 (1.5); 4.1983 (0.7); 4.1804 (0.7); 4.1671 (1.3); 4.1498 (1.8); 4.1302 (2.2); 4.1228 (1.7); 4.1122 (3.7); 4.1050 (4.8); 4.0945 (3.2); 4.0873 (4.6); 4.0764 (1.0); 4.0694 (1.4); 3.8482 (1.0); 3.8147 (0.8); 3.7834 (1.1); 3.7395 (1.0); 3.7053 (0.6); 3.4581 (16.0); 3.1667 (1.2); 3.0383 (0.8); 3.0128 (0.8); 2.8972 (1.1); 2.8862 (0.8); 2.8567 (1.3); 2.8465 (1.0); 2.8293 (0.8); 2.7991 (1.0); 2.7893 (1.0); 2.6745 (1.0); 2.6700 (1.4); 2.6655 (0.9); 2.5981 (1.2); 2.5913 (1.4); 2.5760 (1.5); 2.5590 (0.6); 2.5368 (2.0); 2.5235 (4.2); 2.5188 (6.2); 2.5101 (83.2); 2.5056 (178.8); 2.5010 (248.2); 2.4963 (172.2); 2.4918 (75.6); 2.4622 (0.9); 2.4403 (1.3); 2.4001 (1.6); 2.3780 (1.0); 2.3324 (1.3); 2.3278 (1.6); 2.3231 (1.2); 2.3015 (0.5); 2.2781 (1.0); 2.2648 (1.0); 2.2531 (1.4); 2.2410 (1.4); 2.2043 (1.7); 2.1921 (1.4); 2.1708 (1.2); 2.1402 (1.3); 2.1158 (1.1); 2.0962 (1.2); 2.0608 (1.1); 1.6470 (1.9); 1.6141 (2.2); 1.5103 (0.8); 1.3485 (0.5); 1.2147 (4.0); 1.1970 (7.8); 1.1943 (7.2); 1.1888 (3.8); 1.1820 (6.9); 1.1765 (12.8); 1.1711 (6.1); 1.1643 (11.9); 1.1588 (5.9); 1.1534 (2.9); 1.1466 (5.2); 0.0080 (1.4); -0.0002 (47.2); -0.0086 (1.2) I.1-305: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.4725 (1.2); 8.1108 (0.9); 8.1085 (1.0); 8.0899 (1.0); 8.0876 (1.0); 7.8869 (1.0); 7.8834 (1.1); 7.8670 (1.1); 7.8635 (1.1); 7.6090 (0.6); 7.6048 (0.6); 7.5905 (0.7); 7.5868 (0.8); 7.5842 (0.6); 7.5698 (0.6); 7.5657 (0.6); 7.2211 (0.8); 7.2181 (0.8); 7.2026 (1.0); 7.2013 (1.0); 7.1997 (1.0); 7.1985 (1.0); 7.1830 (0.8); 7.1800 (0.7); 7.1015 (7.5); 4.6827 (0.9); 4.6446 (1.0); 4.1027 (1.0); 4.0647 (0.9); 3.8249 (16.0); 3.8111 (0.5); 3.6473 (1.5); 2.8263 (0.6); 2.8150 (0.6); 2.7893 (0.8); 2.7780 (0.7); 2.5236 (0.6); 2.5189 (1.0); 2.5102 (14.4); 2.5056 (31.1); 2.5010 (43.5); 2.4964 (30.6); 2.4918 (14.3); 2.4767 (0.9); 2.4556 (0.7); 2.4254 (0.5); 2.2801 (0.6); 2.2667 (0.6); 2.2496 (8.1); 2.0732 (0.6); -0.0002 (5.1) I.1-306: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.9796 (1.2); 7.5544 (1.5); 7.5515 (1.9); 7.5468 (0.6); 7.5327 (2.1); 7.5301 (1.9); 7.3081 (1.7); 7.3032 (0.6); 7.2895 (2.2); 7.2871 (1.9); 7.2728 (0.6); 7.2683 (1.7); 7.1246 (16.0); 7.0552 (0.8); 7.0368 (1.3); 7.0183 (0.6); 4.6938 (1.0); 4.6558 (1.1); 4.0696 (1.1); 4.0316 (1.0); 3.8135 (0.6); 3.3228 (17.6); 2.7593 (0.7); 2.7482 (0.7); 2.7233 (0.9); 2.7122 (0.8); 2.5102 (6.6); 2.5056 (14.3); 2.5010 (20.0); 2.4963 (14.0); 2.4917 (6.2); 2.3892 (1.0); 2.3728 (0.6); 2.3671 (1.1); 2.3527 (0.9); 2.3309 (0.7); 2.2918 (0.6); 2.2811 (1.0); 2.2731 (9.7); 2.0730 (0.9); -0.0002 (2.5) I.1-307: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2756 (1.9); 8.2707 (1.9); 8.2395 (0.6); 8.2338 (0.6); 7.6813 (1.2); 7.6750 (1.2); 7.6607 (1.5); 7.6545 (1.5); 7.5234 (0.8); 7.5038 (0.6); 7.4882 (2.4); 7.4869 (2.4); 7.4678 (2.0); 7.4664 (2.0); 7.1415 (1.2); 7.1212 (5.0); 7.1093 (5.6); 7.0886 (1.3); 7.0765 (1.2); 7.0414 (1.3); 7.0215 (0.6); 4.6772 (1.2); 4.6390 (1.7); 4.5249 (0.9); 4.5167 (0.8); 4.5074 (0.8); 4.4873 (2.3); 4.4519 (2.3); 4.4140 (0.8); 4.0595 (1.4); 4.0219 (1.6); 3.7925 (0.6); 3.7800 (0.7); 3.7701 (0.6); 3.7602 (0.6); 3.5480 (2.4); 2.8634 (16.0); 2.8351 (0.8); 2.8254 (0.8); 2.7940 (1.0); 2.7847 (0.9); 2.7549 (4.1); 2.5238 (1.0); 2.5191 (1.6); 2.5104 (22.7); 2.5058 (49.6); 2.5012 (69.8); 2.4966 (48.8); 2.4920 (22.6); 2.4744 (1.0); 2.4513 (1.1); 2.4294 (0.6); 2.4121 (0.7); 2.3939 (0.6); 2.3704 (0.6); 2.3282 (0.5); 2.2740 (10.3); 2.2594 (3.3); 2.2411 (1.0); 2.2285 (0.8); 2.1995 (0.5); 2.1876 (0.6); 2.1350 (0.6); 2.1229 (0.5); 2.1154 (0.6); 2.1037 (0.7); 1.6496 (0.5); 1.6416 (0.6); 1.6306 (0.5); 0.0080 (1.0); -0.0002 (33.4); -0.0085 (1.0) I.1-308: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9138 (2.4); 8.8925 (2.4); 7.3672 (0.6); 7.3634 (0.7); 7.3441 (4.2); 7.3408 (4.6); 7.3370 (2.2); 7.3280 (5.4); 7.3254 (7.4); 7.3225 (8.7); 7.3199 (7.9); 7.3063 (6.4); 7.3041 (7.4); 7.2603 (3.8); 7.2533 (16.0); 7.2451 (5.4); 7.2348 (9.3); 7.2312 (7.2); 7.2263 (2.0); 7.2221 (1.2); 7.2180 (1.2); 7.2146 (0.6); 7.1875 (0.7); 7.1838 (0.8); 7.1749 (0.7); 7.1711 (0.9); 7.1676 (1.3); 7.1641 (1.4); 7.1548 (1.3); 7.1516 (1.4); 7.1476 (0.9); 7.1435 (0.9); 7.1346 (0.8); 7.1312 (0.8); 7.0655 (1.4); 7.0495 (1.9); 7.0301 (1.0); 6.1065 (3.0); 6.0853 (2.9); 4.7258 (2.1); 4.6859 (2.4); 4.2210 (2.6); 4.1813 (2.3); 3.8224 (0.8); 3.8119 (1.2); 3.8016 (1.5); 3.7917 (1.2); 3.7812 (0.9); 3.4995 (3.8); 3.1668 (1.2); 2.6716 (1.9); 2.6607 (1.9); 2.6369 (2.1); 2.6258 (1.9); 2.5232 (1.7); 2.5185 (2.5); 2.5099 (32.0); 2.5053 (69.1); 2.5007 (95.9); 2.4961 (67.1); 2.4915 (30.0); 2.3845 (2.3); 2.3627 (2.7); 2.3497 (1.8); 2.3391 (1.6); 2.3277 (2.4); 2.3187 (1.7); 2.2968 (1.2); 2.2678 (1.1); 2.2547 (1.3); 2.2438 (1.6); 2.2308 (1.6); 2.2130 (0.6); 2.2018 (0.8); 2.1891 (0.8); 2.1245 (0.6); 2.1049 (1.0); 2.0929 (0.8); 2.0854 (0.7); 2.0811 (0.9); 2.0732 (1.4); 2.0537 (0.7); 2.0494 (1.0); 1.7912 (0.5); 1.7789 (0.8); 1.7680 (1.1); 1.7579 (1.0); 1.7465 (1.0); 1.7364 (1.0); 1.7254 (0.6); 0.0080 (1.2); -0.0002 (40.1); -0.0086 (1.1) I.1-309: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5185 (0.4); 7.2603 (76.8); 7.2598 (81.3); 7.2462 (0.4); 7.1586 (1.4); 7.1440 (1.3); 7.1378 (8.3); 7.1285 (8.4); 7.1076 (1.5); 6.9958 (0.4); 5.3280 (0.8); 4.6982 (0.3); 4.6600 (2.1); 4.6224 (2.4); 4.2056 (2.3); 4.1934 (0.3); 4.1680 (2.0); 4.1308 (0.5); 4.1130 (0.5); 3.9876 (0.4); 3.9764 (0.7); 3.9673 (0.9); 3.9562 (1.5); 3.9450 (0.9); 3.9360 (0.8); 3.9246 (0.4); 2.6555 (0.5); 2.6475 (0.9); 2.6381 (1.2); 2.6297 (1.3); 2.6206 (1.0); 2.6121 (0.6); 2.5317 (0.4); 2.5128 (0.5); 2.4894 (1.2); 2.4681 (2.4); 2.4561 (1.5); 2.4469 (1.1); 2.4319 (1.8); 2.4202 (2.2); 2.4100 (1.1); 2.3996 (1.4); 2.3859 (1.3); 2.3812 (0.8); 2.3674 (0.5); 2.3569 (0.9); 2.3431 (0.8); 2.3295 (16.0); 2.3186 (2.4); 2.2677 (0.6); 2.2482 (0.9); 2.2436 (0.5); 2.2352 (0.6); 2.2288 (0.5); 2.2242 (0.7); 2.2158 (1.0); 2.2111 (0.6); 2.2049 (0.4); 2.1961 (0.5); 2.1915 (0.8); 2.1719 (0.4); 2.0805 (1.8); 2.0601 (1.8); 2.0435 (3.3); 2.0240 (1.5); 1.8274 (0.4); 1.8143 (0.6); 1.8034 (0.8); 1.7937 (0.8); 1.7807 (0.8); 1.7706 (0.8); 1.7600 (0.6); 1.7467 (0.4); 1.5517 (10.0); 1.2764 (0.6); 1.2585 (1.3); 1.2411 (0.6); 0.7667 (1.0); 0.7584 (1.0); 0.7508 (2.8); 0.7365 (2.2); 0.7334 (2.4); 0.7279 (1.1); 0.7214 (1.1); 0.4283 (0.9); 0.4240 (1.1); 0.4175 (2.8); 0.4087 (2.7); 0.4040 (2.0); 0.3944 (0.8); 0.0083 (0.9); 0.0000 (35.8) I.1-310: 1H-NMR (400.1 MHz, d6-DMSO): δ= 12.2691 (1.0); 7.4362 (1.3); 7.4309 (1.4); 7.4221 (1.6); 7.4168 (1.5); 7.4112 (1.6); 7.4007 (6.2); 7.3952 (3.4); 7.3811 (6.4); 7.3742 (5.7); 7.3609 (3.1); 7.3549 (4.2); 7.3439 (1.8); 7.3338 (2.0); 7.1955 (1.6); 7.1903 (1.8); 7.1799 (3.1); 7.1745 (3.0); 7.1690 (3.0); 7.1638 (2.9); 7.1534 (1.5); 7.1480 (1.3); 5.0782 (0.8); 5.0605 (2.6); 5.0424 (2.7); 5.0249 (0.9); 5.0067 (0.8); 4.9887 (2.5); 4.9708 (2.6); 4.9530 (0.8); 4.0291 (0.5); 4.0203 (1.1); 4.0107 (1.3); 4.0049 (1.3); 4.0004 (1.6); 3.9970 (1.6); 3.9917 (1.3); 3.9869 (1.4); 3.9770 (1.3); 3.9679 (0.6); 3.7143 (0.6); 3.7056 (1.1); 3.6945 (1.1); 3.6898 (1.2); 3.6856 (1.5); 3.6815 (1.6); 3.6707 (1.2); 3.6618 (1.2); 3.6539 (0.6); 3.5507 (0.7); 3.4161 (0.4); 3.3841 (0.4); 3.3736 (0.4); 3.3191 (65.5); 3.2699 (1.2); 3.1688 (1.1); 2.6791 (0.4); 2.6747 (0.8); 2.6700 (1.1); 2.6655 (0.9); 2.6573 (2.3); 2.6485 (2.3); 2.6174 (3.1); 2.6085 (3.1); 2.5986 (0.8); 2.5940 (0.6); 2.5735 (0.4); 2.5235 (2.5); 2.5188 (3.7); 2.5100 (56.5); 2.5056 (123.5); 2.5010 (173.8); 2.4964 (128.1); 2.4919 (62.3); 2.4753 (3.6); 2.4520 (5.0); 2.4474 (2.8); 2.4308 (4.0); 2.4196 (4.7); 2.4110 (2.9); 2.3953 (3.8); 2.3797 (2.6); 2.3555 (2.6); 2.3371 (0.5); 2.3325 (0.9); 2.3279 (1.2); 2.3233 (0.9); 2.2678 (2.3); 2.2587 (2.4); 2.2276 (4.0); 2.2186 (4.1); 2.2108 (1.3); 2.2025 (2.0); 2.1971 (1.6); 2.1928 (2.1); 2.1858 (5.4); 2.1781 (5.0); 2.1684 (4.0); 2.1614 (2.9); 2.1528 (4.3); 2.1399 (5.2); 2.1307 (3.1); 2.1161 (4.8); 2.1001 (2.9); 2.0935 (1.1); 2.0890 (1.1); 2.0823 (1.8); 2.0763 (2.9); 2.0593 (1.2); 2.0377 (0.5); 1.7216 (0.9); 1.7121 (1.4); 1.7055 (2.4); 1.6973 (1.2); 1.6897 (2.7); 1.6839 (3.8); 1.6683 (1.8); 1.6603 (1.6); 1.6523 (1.8); 1.6426 (0.9); 1.5865 (16.0); 1.5684 (16.0); 1.5436 (14.8); 1.5256 (14.7) I.1-312: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1436 (2.3); 7.1242 (7.0); 7.1038 (5.4); 7.0830 (2.3); 3.3907 (1.1); 3.3314 (1260.6); 3.2803 (4.0); 3.1676 (4.2); 2.7554 (2.3); 2.6746 (3.3); 2.6700 (4.8); 2.6655 (3.4); 2.5235 (9.0); 2.5188 (14.0); 2.5102 (259.8); 2.5056 (572.3); 2.5010 (802.6); 2.4965 (566.1); 2.4919 (258.8); 2.4550 (3.3); 2.4499 (3.4); 2.4128 (2.4); 2.3325 (3.9); 2.3278 (5.7); 2.3232 (4.2); 2.2749 (16.0); 2.0728 (3.5); 1.8865 (2.1); 1.6493 (1.2); 1.0877 (1.2); 1.0692 (2.2); 1.0514 (1.4); -0.0002 (9.4) I.1-314: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.6278 (0.8); 8.0424 (0.7); 7.2236 (1.9); 7.2226 (2.0); 7.2018 (2.1); 7.2007 (2.2); 7.1386 (1.1); 7.1185 (3.2); 7.0998 (3.6); 7.0794 (2.5); 7.0741 (1.5); 6.9990 (1.6); 6.9929 (1.6); 6.7205 (1.2); 6.7145 (1.1); 6.6988 (1.0); 6.6928 (1.0); 4.6611 (0.9); 4.6233 (1.0); 4.0014 (1.0); 3.9635 (0.9); 3.7458 (16.0); 3.4762 (7.2); 3.3174 (0.9); 3.3023 (1.0); 3.2841 (0.5); 2.7724 (0.9); 2.7542 (1.5); 2.7359 (0.8); 2.5188 (0.5); 2.5101 (9.0); 2.5055 (19.8); 2.5009 (27.4); 2.4963 (19.5); 2.4917 (8.4); 2.4727 (0.7); 2.4616 (0.7); 2.3265 (0.6); 2.2735 (7.2); 2.2362 (0.5); 2.2260 (0.6); 2.2122 (0.6); 2.1202 (0.7); 2.0976 (0.7); 2.0856 (0.6); 2.0727 (0.7); 2.0629 (0.6); -0.0002 (1.2) I.1-318: 1H-NMR (400.1 MHz, d6-DMSO): δ= 11.4836 (1.4); 7.2489 (0.3); 7.2321 (0.3); 7.1991 (0.4); 7.1792 (0.4); 7.1314 (4.1); 7.1202 (4.3); 4.6747 (1.0); 4.6373 (1.2); 4.6032 (0.4); 4.4149 (0.3); 4.3513 (0.3); 4.3082 (0.3); 4.2870 (0.4); 4.2644 (0.4); 4.2499 (0.4); 4.2284 (0.4); 4.2148 (0.4); 4.1761 (0.4); 4.1732 (0.4); 4.1404 (0.5); 4.1281 (0.4); 4.1103 (0.4); 4.0872 (0.5); 4.0828 (0.5); 4.0689 (0.5); 4.0539 (0.5); 4.0104 (1.4); 3.9748 (1.3); 3.9426 (0.6); 3.9256 (0.6); 3.9098 (0.6); 3.8889 (0.6); 3.8618 (0.6); 3.8241 (0.6); 3.7866 (0.7); 3.7538 (0.8); 3.7078 (1.5); 3.6998 (1.4); 3.6480 (0.9); 3.5854 (1.0); 3.5828 (1.0); 3.5663 (1.0); 3.5352 (1.1); 3.4436 (1.3); 3.3391 (18.2); 3.2785 (1.2); 3.2364 (0.9); 3.2182 (0.9); 3.1982 (0.8); 3.1902 (0.9); 3.1703 (0.9); 3.1399 (0.9); 3.1315 (0.9); 3.0964 (1.0); 3.0809 (1.1); 3.0708 (1.0); 3.0671 (1.0); 3.0547 (1.0); 3.0504 (1.0); 3.0119 (1.2); 2.9768 (1.2); 2.9718 (1.2); 2.9397 (1.4); 2.8992 (1.5); 2.8906 (1.5); 2.8650 (1.7); 2.7710 (16.0); 2.7032 (2.7); 2.6750 (3.0); 2.5785 (3.0); 2.4997 (46.7); 2.4063 (1.3); 2.3781 (1.5); 2.3578 (2.0); 2.3354 (2.0); 2.2779 (6.6); 2.2245 (0.7); 2.1373 (0.4); 2.1212 (0.7); 2.0937 (0.8); 2.0686 (0.7); 1.7201 (0.7); 1.7097 (0.8); 1.6700 (0.5); 0.0274 (0.5) I.1-319: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4865 (0.9); 8.4679 (1.5); 8.4490 (1.0); 7.2890 (0.8); 7.2703 (2.0); 7.2675 (1.9); 7.2530 (3.2); 7.2392 (0.6); 7.2327 (2.2); 7.2307 (2.3); 7.2142 (2.2); 7.2114 (2.3); 7.2006 (4.5); 7.1840 (2.3); 7.1713 (1.5); 7.1624 (4.6); 7.1581 (7.1); 7.1434 (1.3); 7.1320 (0.9); 7.1273 (0.8); 7.0623 (1.8); 7.0475 (1.4); 4.6617 (1.7); 4.6221 (1.9); 4.5089 (0.5); 4.4563 (0.6); 4.4479 (0.5); 4.4368 (0.5); 3.9971 (1.1); 3.9741 (1.1); 3.9585 (1.0); 3.9348 (1.0); 3.5991 (15.8); 3.5939 (16.0); 3.5716 (0.8); 3.5483 (0.7); 3.4108 (8.0); 3.0655 (0.5); 3.0520 (1.0); 3.0389 (0.6); 3.0311 (0.8); 3.0179 (1.4); 3.0047 (0.7); 2.8671 (1.1); 2.8429 (1.2); 2.8333 (0.9); 2.8092 (0.8); 2.6741 (0.6); 2.6695 (0.9); 2.6649 (0.6); 2.5229 (2.3); 2.5183 (3.6); 2.5096 (51.8); 2.5050 (112.3); 2.5004 (155.8); 2.4958 (109.0); 2.4912 (49.4); 2.4732 (1.4); 2.4682 (1.4); 2.4576 (1.2); 2.4495 (1.3); 2.4396 (0.9); 2.3319 (0.8); 2.3272 (1.0); 2.3227 (0.7); 2.3122 (0.8); 2.2914 (1.0); 2.2704 (1.5); 2.2482 (0.9); 2.2233 (0.8); 2.2051 (11.5); 2.2020 (12.2); 2.1699 (1.3); 2.1597 (1.1); 2.1432 (1.0); 2.1358 (0.9); 2.1087 (0.6); 2.0851 (1.1); 0.0080 (2.4); -0.0002 (80.7); -0.0086 (2.3) I.1-320: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5024 (0.6); 8.4876 (0.7); 8.4829 (0.7); 8.4684 (0.6); 7.2706 (1.0); 7.2683 (1.0); 7.2532 (1.5); 7.2375 (0.7); 7.2336 (0.8); 7.2203 (1.9); 7.2149 (1.8); 7.2064 (3.0); 7.1934 (3.2); 7.1742 (2.9); 7.1069 (1.8); 7.0949 (1.8); 7.0868 (1.2); 7.0746 (1.2); 4.6414 (0.6); 4.6272 (0.6); 4.6031 (0.7); 4.5893 (0.6); 3.9586 (0.6); 3.9204 (0.6); 3.8827 (0.6); 3.8447 (0.6); 3.6013 (16.0); 3.4826 (1.8); 3.0304 (0.6); 3.0182 (0.5); 2.8693 (1.0); 2.8566 (0.6); 2.8445 (0.7); 2.8389 (0.8); 2.8347 (0.9); 2.5310 (0.5); 2.5186 (1.1); 2.5097 (13.6); 2.5052 (29.1); 2.5006 (40.4); 2.4960 (28.9); 2.4914 (13.0); 2.4738 (0.6); 2.1868 (0.6); 2.1760 (0.6); 2.1626 (0.6); 2.1304 (0.9); 2.1202 (0.6); 2.0960 (0.6); 1.1912 (8.7); 1.1874 (9.0); 1.1739 (8.7); 1.1701 (8.8); -0.0002 (14.5) I.1-321: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.7394 (0.5); 8.3515 (1.0); 7.1505 (2.5); 7.1299 (8.7); 7.1152 (11.1); 7.0945 (2.8); 4.7081 (0.9); 4.6707 (1.1); 4.6600 (2.0); 4.6217 (2.3); 4.3155 (0.8); 4.0303 (2.4); 4.0107 (1.1); 3.9921 (2.1); 3.9724 (1.0); 3.7278 (0.9); 3.7170 (1.1); 3.7073 (1.4); 3.6967 (1.2); 3.6857 (0.9); 3.1685 (0.9); 2.7695 (0.5); 2.7586 (0.5); 2.7316 (0.6); 2.7215 (0.6); 2.6700 (0.5); 2.6119 (27.4); 2.5646 (4.4); 2.5237 (1.2); 2.5190 (2.0); 2.5103 (35.9); 2.5057 (79.5); 2.5011 (111.6); 2.4965 (78.9); 2.4919 (36.1); 2.4654 (1.6); 2.4550 (1.8); 2.4305 (1.8); 2.4195 (1.7); 2.3993 (1.3); 2.3756 (1.9); 2.3650 (6.9); 2.3385 (2.0); 2.3277 (1.0); 2.3234 (1.0); 2.3154 (1.0); 2.2780 (16.0); 2.2608 (1.6); 2.2469 (1.4); 2.2274 (0.9); 2.2191 (0.8); 2.2054 (0.7); 2.0976 (0.6); 2.0879 (1.6); 2.0788 (1.0); 2.0731 (1.0); 2.0657 (2.2); 2.0531 (2.1); 2.0469 (1.3); 2.0301 (1.7); 1.7149 (0.6); 1.7045 (0.8); 1.6860 (0.8); 1.6726 (0.8); 1.6623 (0.7); -0.0002 (18.9); -0.0086 (0.6) I.1-322: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9181 (1.7); 8.8964 (1.7); 7.3487 (1.8); 7.3424 (2.0); 7.3386 (1.4); 7.3280 (4.7); 7.3217 (4.1); 7.3120 (4.8); 7.3055 (4.1); 7.2645 (7.8); 7.2549 (8.1); 7.2467 (5.6); 7.2367 (5.3); 7.2281 (1.2); 7.2183 (0.8); 7.1463 (2.7); 7.1260 (6.3); 7.0943 (6.3); 7.0738 (2.8); 6.1132 (2.1); 6.0923 (2.0); 4.6655 (1.8); 4.6278 (2.0); 3.9849 (2.0); 3.9465 (1.7); 3.7375 (0.6); 3.7268 (0.8); 3.7161 (0.9); 3.7070 (0.9); 3.6959 (0.6); 3.3526 (1.0); 3.3183 (139.8); 3.1677 (0.8); 2.6742 (0.8); 2.6696 (1.1); 2.6651 (0.8); 2.6565 (1.2); 2.6451 (1.1); 2.6217 (1.3); 2.6104 (1.3); 2.5934 (1.2); 2.5739 (3.6); 2.5550 (4.0); 2.5355 (2.1); 2.5231 (1.8); 2.5184 (3.2); 2.5098 (61.4); 2.5052 (135.6); 2.5006 (189.8); 2.4960 (133.7); 2.4914 (60.6); 2.3531 (0.6); 2.3312 (2.2); 2.3228 (1.1); 2.3082 (2.0); 2.2952 (1.5); 2.2734 (1.2); 2.2602 (0.8); 2.2463 (1.0); 2.2358 (1.0); 2.2225 (1.0); 2.1941 (0.6); 2.0730 (0.8); 2.0326 (0.6); 2.0074 (0.6); 2.0004 (0.9); 1.9760 (0.7); 1.7313 (0.6); 1.7185 (0.7); 1.7077 (0.7); 1.6859 (0.6); 1.1728 (7.0); 1.1538 (16.0); 1.1348 (6.8); -0.0002 (15.8) I.1-323: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1791 (3.6); 7.1587 (10.4); 7.1375 (7.8); 7.1219 (3.0); 7.1173 (3.2); 7.0997 (1.9); 7.0790 (0.8); 5.0635 (1.3); 5.0563 (1.3); 5.0497 (1.3); 4.7506 (1.3); 4.7120 (2.2); 4.6985 (1.2); 4.6727 (0.8); 4.6601 (1.6); 4.3056 (0.5); 4.2712 (0.5); 4.1686 (1.1); 4.1510 (1.8); 4.1334 (1.4); 4.1255 (1.4); 4.1142 (1.6); 4.1083 (2.8); 4.1058 (2.7); 4.0963 (4.3); 4.0905 (3.6); 4.0882 (3.5); 4.0785 (4.2); 4.0729 (1.0); 4.0608 (1.5); 4.0506 (2.3); 4.0099 (1.6); 3.9699 (0.7); 3.9627 (0.6); 3.7635 (0.6); 3.7524 (0.8); 3.7433 (1.1); 3.7330 (1.2); 3.7217 (1.3); 3.7101 (1.5); 3.7005 (1.4); 3.6909 (1.2); 3.6657 (1.4); 3.5718 (5.9); 3.1659 (2.5); 3.0075 (0.6); 2.9870 (0.5); 2.9621 (0.6); 2.9552 (0.6); 2.8547 (1.0); 2.8448 (0.7); 2.8146 (1.1); 2.8041 (1.1); 2.7924 (0.7); 2.7627 (0.8); 2.7534 (0.8); 2.6790 (0.5); 2.6743 (1.1); 2.6697 (1.6); 2.6651 (1.1); 2.6604 (0.5); 2.6033 (2.0); 2.5843 (6.3); 2.5654 (6.2); 2.5456 (3.0); 2.5401 (1.6); 2.5358 (0.7); 2.5231 (3.7); 2.5185 (6.3); 2.5098 (90.4); 2.5052 (196.0); 2.5006 (275.0); 2.4960 (194.0); 2.4914 (87.1); 2.4766 (2.7); 2.4725 (2.5); 2.4678 (2.0); 2.4632 (1.1); 2.4590 (0.8); 2.4359 (1.1); 2.4137 (1.8); 2.3909 (2.2); 2.3735 (1.7); 2.3514 (1.2); 2.3368 (0.9); 2.3320 (1.3); 2.3274 (1.7); 2.3227 (1.3); 2.3181 (0.9); 2.2693 (1.3); 2.2565 (1.3); 2.2450 (1.9); 2.2318 (1.7); 2.2147 (0.8); 2.2034 (1.1); 2.1907 (1.0); 2.1214 (1.2); 2.1028 (1.3); 2.0843 (2.0); 2.0730 (2.1); 2.0473 (1.4); 1.9086 (1.0); 1.6587 (0.6); 1.6380 (1.6); 1.6276 (1.8); 1.6166 (1.9); 1.6060 (1.8); 1.5962 (1.9); 1.5855 (1.8); 1.5654 (1.5); 1.5330 (1.3); 1.5094 (0.6); 1.4999 (0.7); 1.4869 (0.8); 1.2173 (3.4); 1.1995 (6.1); 1.1900 (6.0); 1.1817 (7.3); 1.1777 (7.5); 1.1722 (15.2); 1.1643 (10.1); 1.1589 (13.6); 1.1572 (13.9); 1.1543 (16.0); 1.1458 (4.7); 1.1397 (6.4); 1.1381 (6.7); 0.0080 (3.4); -0.0002 (123.4); -0.0085 (3.7); -0.0333 (0.8) I.1-324: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2668 (1.7); 8.2466 (1.8); 7.1437 (1.8); 7.1231 (8.0); 7.1112 (8.3); 7.0904 (1.8); 4.6609 (1.9); 4.6225 (2.0); 4.2420 (0.6); 4.2272 (0.8); 4.2193 (0.8); 4.2073 (1.0); 4.1841 (0.7); 4.0555 (2.0); 4.0174 (1.8); 3.7200 (0.6); 3.7097 (0.9); 3.6991 (1.1); 3.6887 (0.9); 3.6786 (0.7); 3.3760 (0.8); 3.3562 (1.6); 3.3244 (311.6); 3.2739 (2.1); 3.1676 (0.8); 2.6746 (1.0); 2.6701 (1.3); 2.6655 (0.9); 2.5236 (3.9); 2.5188 (5.2); 2.5102 (79.8); 2.5056 (175.6); 2.5010 (245.7); 2.4963 (171.1); 2.4918 (77.6); 2.4551 (1.6); 2.4505 (1.8); 2.4460 (1.4); 2.3660 (0.6); 2.3472 (1.2); 2.3278 (2.4); 2.3232 (1.8); 2.3061 (0.9); 2.2760 (16.0); 2.2546 (1.1); 2.2440 (1.2); 2.2299 (1.2); 2.2149 (1.6); 2.2016 (0.7); 2.1935 (1.5); 2.1812 (1.2); 2.1592 (1.1); 2.0729 (0.8); 2.0329 (0.6); 2.0203 (0.6); 2.0079 (0.7); 2.0006 (0.9); 1.9763 (0.7); 1.7170 (0.6); 1.7064 (0.7); 1.6954 (0.7); 1.6746 (0.6); 1.6014 (0.7); 1.5845 (0.7); 1.5699 (0.5); 1.5099 (1.4); 1.4991 (1.7); 1.4849 (2.2); 1.4739 (1.3); 1.4629 (1.2); 0.8910 (9.1); 0.8746 (8.8); 0.8248 (9.0); 0.8085 (8.8); 0.0080 (1.0); -0.0002 (34.1); -0.0085 (1.0) I.1-325: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4143 (3.5); 7.3966 (9.3); 7.3773 (7.7); 7.3360 (5.4); 7.3149 (4.4); 7.2941 (1.8); 7.2198 (10.3); 7.2165 (13.7); 7.1984 (10.2); 7.1280 (2.6); 7.1130 (2.5); 6.9106 (2.5); 4.5335 (2.1); 4.4938 (2.4); 4.1158 (2.5); 4.0738 (2.0); 3.8120 (2.3); 3.3795 (69.8); 3.1666 (4.9); 3.1037 (16.0); 2.6746 (1.9); 2.6700 (2.6); 2.6654 (1.8); 2.5546 (0.8); 2.5500 (1.0); 2.5404 (1.4); 2.5370 (0.7); 2.5234 (7.1); 2.5187 (11.0); 2.5101 (146.5); 2.5055 (316.7); 2.5009 (439.2); 2.4963 (307.5); 2.4917 (137.4); 2.4728 (2.3); 2.4679 (2.2); 2.4499 (0.8); 2.4273 (1.8); 2.3851 (2.0); 2.3808 (2.1); 2.3370 (1.2); 2.3323 (2.2); 2.3278 (2.8); 2.3231 (2.1); 2.2394 (3.8); 2.2185 (4.4); 2.2055 (3.8); 2.1769 (3.0); 2.1419 (2.2); 2.1213 (1.7); 2.0992 (1.8); 2.0733 (2.9); 2.0365 (1.2); 1.6575 (1.8); 0.0080 (3.2); -0.0002 (105.9); -0.0085 (3.0) I.1-326: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0055 (5.1); 7.9960 (5.0); 7.3809 (2.0); 7.3771 (2.1); 7.3604 (4.2); 7.3565 (4.6); 7.3505 (2.3); 7.3407 (3.0); 7.3347 (4.5); 7.3306 (3.9); 7.3141 (2.4); 7.3103 (2.3); 7.2073 (2.5); 7.2034 (2.7); 7.1945 (2.8); 7.1906 (3.4); 7.1874 (4.7); 7.1836 (5.0); 7.1746 (4.6); 7.1710 (5.1); 7.1672 (3.0); 7.1630 (2.9); 7.1542 (2.4); 7.1506 (2.6); 7.0670 (4.7); 7.0509 (6.4); 7.0315 (3.4); 4.7189 (7.5); 4.6791 (8.7); 4.2216 (9.4); 4.1817 (8.0); 3.8117 (1.5); 3.8006 (3.1); 3.7903 (4.2); 3.7802 (5.8); 3.7701 (4.3); 3.7599 (3.1); 3.7488 (1.6); 3.4239 (15.9); 3.1669 (0.9); 2.6750 (0.9); 2.6703 (1.2); 2.6658 (0.8); 2.6005 (1.0); 2.5906 (2.8); 2.5809 (4.0); 2.5724 (6.2); 2.5626 (6.6); 2.5539 (4.0); 2.5444 (3.2); 2.5342 (1.8); 2.5238 (4.0); 2.5191 (5.6); 2.5104 (75.1); 2.5059 (162.0); 2.5012 (225.4); 2.4967 (158.0); 2.4921 (71.3); 2.4711 (0.7); 2.4571 (7.3); 2.4453 (7.2); 2.4220 (8.3); 2.4102 (7.9); 2.3899 (1.8); 2.3703 (2.4); 2.3673 (2.3); 2.3478 (5.5); 2.3281 (6.5); 2.3056 (4.4); 2.2827 (4.4); 2.2692 (5.3); 2.2587 (6.5); 2.2453 (6.2); 2.2411 (2.6); 2.2274 (2.1); 2.2168 (3.3); 2.2037 (3.2); 2.1445 (8.8); 2.1296 (4.7); 2.1234 (9.5); 2.1175 (3.8); 2.1095 (9.2); 2.0982 (5.1); 2.0936 (3.5); 2.0881 (7.9); 2.0787 (2.9); 2.0741 (3.9); 2.0548 (1.5); 1.7474 (2.1); 1.7347 (3.0); 1.7240 (4.2); 1.7138 (3.4); 1.7025 (3.4); 1.6921 (3.8); 1.6816 (2.2); 1.6684 (1.6); 0.6075 (5.0); 0.5954 (12.4); 0.5904 (16.0); 0.5782 (15.3); 0.5725 (13.3); 0.5608 (5.8); 0.5390 (0.7); 0.5209 (0.6); 0.3885 (0.6); 0.3789 (0.6); 0.3484 (5.5); 0.3373 (14.4); 0.3313 (12.8); 0.3272 (12.7); 0.3217 (12.6); 0.3107 (4.2); 0.0080 (2.9); -0.0002 (93.3); -0.0085 (2.8) I.1-327: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9099 (0.9); 7.1438 (2.0); 7.1236 (7.3); 7.1086 (8.0); 7.1031 (1.5); 7.0880 (2.1); 4.6644 (2.0); 4.6265 (2.2); 4.0109 (2.3); 3.9730 (2.0); 3.7199 (0.7); 3.7088 (1.0); 3.6984 (1.1); 3.6888 (0.9); 3.6778 (0.8); 3.3241 (48.4); 3.0688 (0.8); 3.0549 (1.1); 3.0507 (2.7); 3.0369 (2.9); 3.0326 (2.9); 3.0189 (2.8); 3.0147 (1.1); 3.0008 (0.9); 2.5229 (1.0); 2.5182 (1.4); 2.5095 (20.8); 2.5050 (45.0); 2.5003 (62.6); 2.4957 (43.2); 2.4911 (19.3); 2.4834 (1.9); 2.4719 (1.6); 2.4486 (1.8); 2.4374 (1.7); 2.3424 (1.2); 2.3227 (1.2); 2.3001 (0.9); 2.2758 (16.0); 2.2651 (1.3); 2.2512 (1.2); 2.2408 (1.4); 2.2271 (1.4); 2.2093 (0.6); 2.1989 (0.7); 2.1853 (0.7); 2.0985 (1.8); 2.0761 (1.8); 2.0711 (0.6); 2.0640 (1.6); 2.0488 (0.9); 2.0416 (1.6); 2.0363 (0.7); 2.0298 (0.5); 2.0247 (0.7); 2.0172 (1.0); 2.0123 (0.6); 1.9979 (0.6); 1.9930 (0.8); 1.7022 (0.6); 1.6913 (0.8); 1.6807 (0.7); 1.6695 (0.6); 1.6592 (0.7); 1.0000 (7.3); 0.9820 (15.7); 0.9639 (7.0) I.1-328: 1H-NMR (400.1 MHz, d6-DMSO): δ= 7.8524 (0.8); 7.8419 (0.8); 7.6457 (2.1); 7.1439 (1.9); 7.1233 (6.7); 7.1069 (7.3); 7.0864 (2.1); 7.0155 (5.2); 4.6677 (1.9); 4.6298 (2.1); 4.0010 (2.2); 3.9631 (2.0); 3.7275 (0.4); 3.7167 (0.8); 3.7057 (1.0); 3.6953 (1.2); 3.6855 (1.1); 3.6746 (0.9); 3.6638 (0.6); 3.3479 (3.8); 3.1713 (0.6); 2.5497 (9.8); 2.5382 (9.9); 2.5243 (0.5); 2.5189 (0.6); 2.5105 (8.4); 2.5061 (18.0); 2.5016 (25.5); 2.4971 (19.8); 2.4926 (9.5); 2.4857 (2.1); 2.4616 (1.7); 2.4506 (1.5); 2.3831 (0.4); 2.3644 (0.6); 2.3599 (0.5); 2.3411 (1.1); 2.3227 (1.0); 2.3186 (1.0); 2.2991 (0.9); 2.2756 (16.0); 2.2639 (1.5); 2.2564 (0.5); 2.2498 (1.2); 2.2396 (1.4); 2.2258 (1.3); 2.2080 (0.5); 2.1976 (0.7); 2.1840 (0.6); 2.1117 (1.6); 2.0892 (1.6); 2.0768 (1.4); 2.0690 (0.7); 2.0543 (1.4); 2.0495 (0.9); 2.0449 (0.5); 2.0367 (0.6); 2.0301 (0.5); 2.0252 (0.7); 2.0176 (0.9); 2.0129 (0.6); 2.0062 (0.4); 1.9982 (0.5); 1.9934 (0.7); 1.9742 (0.3); 1.9095 (0.4); 1.7078 (0.4); 1.6946 (0.6); 1.6837 (0.9); 1.6736 (0.7); 1.6620 (0.7); 1.6517 (0.8); 1.6409 (0.5); 1.6276 (0.3) I.1-329: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.6096 (3.8); 8.6453 (3.5); 8.6295 (4.5); 8.6128 (0.8); 8.2597 (1.8); 8.2360 (2.5); 8.2172 (2.0); 7.8831 (1.4); 7.8676 (2.4); 7.8325 (2.7); 7.8125 (2.7); 7.7945 (1.4); 7.1251 (4.2); 7.1192 (2.4); 7.1111 (2.4); 7.1050 (6.7); 7.0816 (7.4); 7.0611 (2.7); 4.8193 (0.6); 4.8045 (0.7); 4.7811 (1.6); 4.7666 (1.6); 4.7442 (1.6); 4.7305 (1.7); 4.7062 (0.7); 4.6924 (0.7); 4.6421 (2.3); 4.6257 (0.5); 4.6041 (2.5); 4.2998 (0.5); 4.1116 (0.6); 4.0739 (0.6); 4.0490 (0.5); 3.9870 (2.4); 3.9490 (2.1); 3.7538 (0.8); 3.7428 (1.0); 3.7318 (1.1); 3.7223 (1.0); 3.7116 (0.8); 3.5971 (0.5); 3.5798 (0.6); 3.1667 (2.7); 2.7678 (3.4); 2.7580 (2.9); 2.6705 (0.7); 2.6088 (1.2); 2.5982 (1.2); 2.5739 (1.4); 2.5632 (1.4); 2.5240 (1.3); 2.5193 (1.9); 2.5107 (33.4); 2.5060 (74.0); 2.5014 (103.9); 2.4968 (73.2); 2.4922 (32.8); 2.3375 (0.7); 2.3330 (0.6); 2.3283 (0.7); 2.3236 (0.7); 2.3184 (1.3); 2.2988 (1.1); 2.2947 (1.2); 2.2687 (16.0); 2.2552 (1.3); 2.2410 (1.5); 2.2367 (2.0); 2.2311 (1.6); 2.2143 (2.3); 2.2017 (1.6); 2.1890 (0.8); 2.1793 (1.6); 2.0736 (0.9); 2.0532 (0.8); 2.0488 (0.5); 2.0406 (0.6); 2.0339 (0.5); 2.0289 (0.7); 2.0217 (0.9); 2.0168 (0.6); 2.0021 (0.6); 1.9973 (0.7); 1.7126 (0.7); 1.7018 (1.0); 1.6913 (0.9); 1.6803 (0.9); 1.6696 (0.9); 1.6595 (0.6); 1.0699 (0.7); 1.0520 (1.6); 1.0339 (0.7); 1.0267 (0.6); 1.0093 (1.4); 0.9916 (0.6); 0.0080 (2.0); 0.0064 (0.6); 0.0056 (0.7); 0.0048 (0.8); 0.0039 (1.0); 0.0022 (2.8); -0.0002 (67.1); -0.0051 (0.9); -0.0059 (0.7); -0.0067 (0.6); -0.0085 (1.9) I.1-330: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9359 (3.3); 7.9214 (6.3); 7.9072 (3.3); 7.3843 (1.9); 7.3803 (2.1); 7.3636 (4.3); 7.3596 (4.6); 7.3538 (2.4); 7.3438 (3.0); 7.3377 (4.6); 7.3337 (4.0); 7.3175 (2.4); 7.3137 (2.3); 7.2093 (2.5); 7.2054 (2.6); 7.1966 (2.6); 7.1925 (3.3); 7.1890 (4.7); 7.1856 (5.0); 7.1765 (4.6); 7.1731 (5.1); 7.1691 (3.1); 7.1651 (3.0); 7.1562 (2.5); 7.1527 (2.7); 7.0727 (4.8); 7.0566 (6.5); 7.0372 (3.5); 4.7347 (7.5); 4.6948 (8.7); 4.2353 (9.3); 4.1954 (8.1); 3.8113 (3.1); 3.8002 (4.9); 3.7899 (6.5); 3.7798 (8.0); 3.7699 (6.8); 3.7596 (5.6); 3.7485 (3.8); 2.9174 (1.2); 2.9024 (1.8); 2.8849 (6.1); 2.8674 (11.6); 2.8523 (12.0); 2.8353 (5.9); 2.8174 (1.8); 2.8025 (1.3); 2.6770 (0.7); 2.6721 (1.0); 2.6674 (0.8); 2.5221 (7.9); 2.5121 (64.4); 2.5076 (133.3); 2.5030 (184.6); 2.4984 (130.0); 2.4938 (58.7); 2.4883 (11.4); 2.4762 (8.2); 2.4566 (0.9); 2.4004 (2.1); 2.3810 (2.4); 2.3585 (5.3); 2.3390 (5.4); 2.3355 (5.2); 2.3250 (1.4); 2.3162 (4.2); 2.2899 (4.0); 2.2764 (4.9); 2.2659 (6.0); 2.2525 (5.9); 2.2346 (2.2); 2.2240 (3.2); 2.2117 (9.7); 2.1907 (7.7); 2.1773 (6.5); 2.1559 (6.4); 2.1440 (2.2); 2.1245 (3.8); 2.1124 (2.8); 2.1052 (2.4); 2.1006 (3.5); 2.0931 (4.5); 2.0886 (2.9); 2.0813 (1.7); 2.0734 (2.7); 2.0689 (3.5); 2.0496 (1.5); 1.7686 (2.0); 1.7558 (2.8); 1.7451 (4.0); 1.7346 (3.4); 1.7237 (3.4); 1.7132 (3.6); 1.7027 (2.3); 1.6895 (2.0); 1.6558 (5.3); 1.6330 (16.0); 1.6060 (11.1); 1.3506 (1.7); 1.3411 (2.0); 1.3313 (2.5); 1.3235 (3.0); 1.3154 (2.6); 1.3045 (2.2); 1.2963 (2.0); 1.2783 (0.9); 1.1972 (1.3); 1.1666 (4.1); 1.1350 (8.7); 1.1196 (6.6); 1.1091 (6.2); 1.0787 (1.7); 1.0489 (0.6); 0.8691 (2.7); 0.8415 (5.9); 0.8164 (4.9); 0.7889 (1.7); 0.7801 (1.8); 0.0080 (1.0); -0.0002 (37.0); -0.0086 (1.1) I.1-331: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.7492 (0.6); 8.4977 (1.2); 8.4764 (1.2); 8.3071 (1.5); 8.2884 (1.6); 8.1752 (1.6); 8.1533 (2.0); 8.1346 (1.2); 7.2623 (1.5); 7.2450 (4.7); 7.2410 (5.0); 7.2324 (12.1); 7.2264 (9.4); 7.2210 (8.2); 7.2057 (8.6); 7.1919 (7.2); 7.1725 (5.5); 7.1592 (8.4); 7.1560 (8.7); 7.1484 (5.0); 7.1410 (6.9); 7.1378 (6.5); 7.1300 (3.6); 7.1220 (1.7); 7.1108 (1.6); 7.0980 (3.0); 7.0813 (2.1); 7.0357 (2.3); 7.0206 (1.9); 4.6177 (3.0); 4.5783 (3.1); 4.5388 (0.8); 4.5212 (0.7); 4.4587 (0.9); 4.4466 (1.0); 4.4386 (1.1); 4.4270 (1.0); 4.4056 (0.6); 3.9611 (1.3); 3.9337 (1.8); 3.9225 (1.2); 3.8931 (1.5); 3.5973 (0.6); 3.5532 (3.0); 3.5374 (2.2); 3.3639 (85.4); 3.1673 (4.3); 3.0967 (1.3); 3.0759 (1.5); 3.0538 (1.3); 3.0408 (1.2); 2.9863 (0.9); 2.9620 (1.1); 2.9513 (1.0); 2.9423 (1.2); 2.9202 (1.2); 2.9079 (0.8); 2.8854 (0.8); 2.8490 (0.8); 2.8242 (0.8); 2.7906 (0.6); 2.6743 (4.1); 2.6696 (6.2); 2.6651 (5.0); 2.6605 (2.5); 2.6316 (1.3); 2.6052 (1.2); 2.5498 (2.2); 2.5451 (2.9); 2.5399 (3.6); 2.5350 (2.8); 2.5300 (2.5); 2.5231 (13.3); 2.5184 (21.2); 2.5097 (309.4); 2.5052 (669.1); 2.5006 (935.7); 2.4960 (657.9); 2.4914 (295.3); 2.4634 (1.8); 2.4587 (0.8); 2.4495 (0.9); 2.4450 (1.0); 2.4182 (2.3); 2.4077 (2.2); 2.3841 (2.9); 2.3742 (2.4); 2.3566 (1.3); 2.3367 (2.2); 2.3320 (4.3); 2.3273 (5.8); 2.3227 (4.3); 2.3183 (2.1); 2.2839 (1.6); 2.2598 (1.3); 2.2396 (1.1); 2.2193 (2.8); 2.1922 (16.0); 2.1831 (12.6); 2.1592 (1.4); 2.1370 (1.7); 2.1230 (1.4); 2.1119 (1.4); 2.0946 (1.6); 2.0857 (1.9); 2.0730 (2.3); 2.0618 (1.8); 2.0522 (1.4); 2.0284 (1.2); 1.7478 (0.9); 1.7244 (0.7); 1.6381 (0.6); 1.5491 (0.8); 1.2439 (0.7); 0.1462 (1.2); 0.0080 (10.5); -0.0002 (385.4); -0.0086 (11.6); -0.0332 (1.4); - 0.1497 (1.2) I.1-332: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2619 (25.2); 7.1191 (2.5); 7.1134 (29.1); 7.1062 (2.2); 7.0978 (2.6); 7.0901 (1.0); 7.0844 (2.3); 7.0030 (2.8); 6.9976 (0.9); 6.9866 (0.8); 6.9813 (4.7); 6.9758 (0.8); 6.9649 (0.7); 6.9596 (1.9); 5.3536 (0.6); 5.2980 (1.0); 4.7087 (1.8); 4.6712 (2.0); 4.1166 (1.8); 4.0791 (1.6); 3.9393 (0.6); 3.9292 (0.7); 3.9188 (1.1); 3.9084 (0.7); 3.8983 (0.6); 3.4713 (0.8); 3.4532 (1.3); 3.4427 (0.6); 3.4381 (1.2); 3.4253 (1.2); 3.4205 (0.6); 3.4105 (1.2); 3.3930 (0.7); 2.7523 (1.8); 2.7346 (3.6); 2.7170 (1.7); 2.4898 (1.4); 2.4784 (1.3); 2.4642 (0.9); 2.4539 (1.5); 2.4423 (2.2); 2.4216 (0.8); 2.4144 (0.9); 2.4001 (1.0); 2.3902 (1.1); 2.3761 (1.2); 2.3474 (0.6); 2.3330 (0.8); 2.3241 (16.0); 2.2019 (0.7); 2.1888 (0.5); 2.1779 (0.6); 2.1694 (0.8); 2.1647 (0.6); 2.1452 (0.7); 2.0716 (1.5); 2.0504 (1.5); 2.0356 (1.3); 2.0144 (1.3); 1.7359 (0.6); 1.7263 (0.6); 1.7130 (0.6); 1.7029 (0.5); -0.0002 (7.5) I.1-333: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9199 (1.7); 8.8986 (1.8); 7.3478 (2.0); 7.3425 (2.3); 7.3380 (1.4); 7.3269 (5.3); 7.3245 (4.2); 7.3216 (4.5); 7.3112 (5.0); 7.3055 (4.7); 7.2640 (8.3); 7.2544 (8.8); 7.2461 (5.9); 7.2363 (5.6); 7.2276 (1.3); 7.2219 (0.7); 7.2181 (0.9); 7.2054 (1.3); 7.1865 (3.1); 7.1677 (2.0); 7.0643 (1.8); 7.0454 (1.4); 6.9735 (3.2); 6.9508 (1.4); 6.1123 (2.2); 6.0911 (2.2); 4.6660 (1.9); 4.6276 (2.1); 3.9922 (2.1); 3.9538 (1.9); 3.7536 (0.6); 3.7431 (0.9); 3.7328 (1.0); 3.7227 (0.9); 3.7117 (0.6); 3.3152 (48.3); 2.6741 (0.6); 2.6694 (0.8); 2.6649 (0.6); 2.6531 (1.2); 2.6421 (1.2); 2.6185 (1.5); 2.6075 (1.4); 2.5308 (0.6); 2.5229 (2.3); 2.5182 (3.4); 2.5095 (46.1); 2.5050 (99.7); 2.5004 (139.2); 2.4958 (97.8); 2.4912 (43.8); 2.4673 (0.5); 2.3609 (0.5); 2.3416 (1.2); 2.3322 (2.1); 2.3272 (1.3); 2.3225 (1.7); 2.3104 (1.6); 2.2982 (2.0); 2.2754 (2.3); 2.2649 (16.0); 2.2509 (1.3); 2.2373 (1.2); 2.2089 (0.6); 2.1957 (0.6); 2.0729 (0.8); 2.0470 (0.7); 2.0346 (0.5); 2.0230 (0.7); 2.0152 (0.9); 1.9913 (0.7); 1.7403 (0.6); 1.7296 (0.8); 1.7196 (0.7); 1.7079 (0.7); 1.6978 (0.7); 0.0080 (1.9); -0.0002 (62.8); -0.0085 (1.8) I.1-334: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4143 (3.5); 7.3966 (9.3); 7.3774 (7.7); 7.3357 (5.3); 7.3144 (4.4); 7.2936 (1.8); 7.2198 (10.2); 7.2166 (13.7); 7.1986 (10.3); 7.1265 (2.6); 7.1137 (2.5); 6.9103 (2.5); 4.5349 (2.1); 4.4944 (2.4); 4.1148 (2.5); 4.0751 (2.1); 3.8108 (2.4); 3.5617 (9.8); 3.1666 (2.1); 3.1039 (16.0); 2.6794 (0.6); 2.6747 (1.3); 2.6701 (1.8); 2.6655 (1.3); 2.6609 (0.6); 2.5512 (0.6); 2.5404 (1.0); 2.5236 (4.8); 2.5189 (7.4); 2.5102 (101.8); 2.5057 (220.3); 2.5011 (306.7); 2.4965 (214.8); 2.4919 (96.8); 2.4243 (1.8); 2.3894 (2.1); 2.3372 (0.9); 2.3325 (1.6); 2.3279 (2.1); 2.3233 (1.6); 2.2399 (3.8); 2.2185 (4.4); 2.2049 (3.8); 2.1774 (2.9); 2.1419 (2.2); 2.1229 (1.7); 2.0992 (1.8); 2.0735 (2.1); 2.0586 (1.4); 2.0369 (1.2); 1.6579 (1.8); 0.0080 (4.3); - 0.0002 (139.5); -0.0086 (4.0) I.1-337: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3557 (0.7); 7.3346 (0.8); 7.2064 (0.5); 7.1867 (0.9); 7.1741 (0.8); 7.1701 (0.6); 7.0964 (0.6); 7.0807 (0.8); 4.7602 (0.8); 4.7216 (1.0); 4.7007 (0.5); 4.2677 (1.1); 4.2288 (1.0); 4.2046 (2.5); 4.0381 (3.8); 4.0344 (3.7); 3.8314 (0.6); 3.8214 (0.7); 3.8116 (0.7); 3.8014 (0.6); 3.6734 (7.6); 3.6199 (16.0); 3.3789 (32.3); 3.1663 (1.6); 2.9682 (14.8); 2.8497 (0.6); 2.8394 (0.6); 2.8092 (0.9); 2.7989 (0.8); 2.7689 (5.6); 2.6791 (0.5); 2.6744 (1.0); 2.6699 (1.3); 2.6652 (0.9); 2.5693 (1.0); 2.5469 (1.5); 2.5401 (1.2); 2.5344 (0.9); 2.5290 (1.4); 2.5233 (3.0); 2.5186 (4.7); 2.5099 (69.4); 2.5054 (150.9); 2.5007 (209.7); 2.4961 (147.6); 2.4916 (66.4); 2.4326 (0.6); 2.4082 (0.8); 2.3322 (1.0); 2.3275 (1.3); 2.3230 (1.0); 2.2558 (0.5); 2.2431 (0.8); 2.2318 (0.7); 2.2018 (0.6); 2.1947 (1.2); 2.1795 (0.6); 2.1478 (0.7); 1.6716 (0.5); 0.0080 (1.5); -0.0002 (51.2); -0.0086 (1.5) I.1-338: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4209 (1.1); 7.4031 (2.7); 7.3842 (2.3); 7.3583 (0.9); 7.3409 (0.8); 7.1848 (3.9); 7.1811 (5.5); 7.1761 (1.5); 7.1636 (4.0); 7.1541 (0.6); 7.1296 (2.6); 7.1104 (3.1); 6.9988 (2.0); 6.9811 (1.5); 4.4267 (0.7); 4.3888 (0.8); 3.9487 (1.2); 3.9107 (1.2); 3.7862 (0.8); 3.7760 (1.0); 3.7662 (1.1); 3.7563 (0.9); 3.7463 (0.7); 3.1663 (0.7); 3.1072 (5.9); 2.6107 (1.5); 2.5917 (4.9); 2.5727 (5.0); 2.5537 (1.8); 2.5442 (0.5); 2.5384 (0.6); 2.5336 (0.8); 2.5235 (1.4); 2.5188 (2.0); 2.5101 (23.7); 2.5056 (50.5); 2.5010 (70.0); 2.4964 (48.9); 2.4918 (21.6); 2.4392 (0.6); 2.4104 (0.6); 2.4055 (0.7); 2.4008 (0.7); 2.2136 (1.2); 2.1996 (1.3); 2.1852 (1.0); 2.1063 (0.6); 2.0858 (0.6); 2.0734 (0.9); 2.0546 (0.6); 2.0031 (0.5); 1.6010 (0.5); 1.1927 (7.3); 1.1737 (16.0); 1.1547 (7.1); 0.0080 (1.2); -0.0002 (39.8); -0.0085 (1.1) I.1-339: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0320 (1.0); 7.1438 (1.9); 7.1236 (7.4); 7.1095 (8.2); 7.0889 (2.0); 4.6690 (2.0); 4.6312 (2.2); 4.0083 (2.2); 3.9701 (2.0); 3.7116 (0.6); 3.7010 (0.9); 3.6907 (1.1); 3.6806 (0.9); 3.6696 (0.7); 3.3116 (121.2); 3.2917 (5.4); 3.2606 (0.5); 3.2248 (38.3); 3.2048 (1.3); 3.2020 (1.3); 3.1916 (2.6); 3.1879 (2.5); 3.1782 (2.3); 3.1731 (1.9); 3.1682 (1.2); 3.1646 (0.9); 3.1585 (0.8); 2.6741 (0.6); 2.6695 (0.8); 2.6648 (0.6); 2.5230 (1.8); 2.5183 (2.6); 2.5096 (47.1); 2.5050 (101.4); 2.5004 (141.9); 2.4958 (100.0); 2.4912 (44.6); 2.4735 (2.2); 2.4623 (1.8); 2.3656 (0.6); 2.3461 (1.2); 2.3272 (1.8); 2.3229 (1.5); 2.3040 (0.9); 2.2758 (16.0); 2.2604 (1.0); 2.2470 (1.2); 2.2363 (1.3); 2.2228 (1.3); 2.2053 (0.6); 2.1944 (0.7); 2.1810 (0.7); 2.1501 (1.7); 2.1278 (1.7); 2.1156 (1.6); 2.0933 (1.4); 2.0716 (0.7); 2.0403 (0.8); 2.0277 (0.6); 2.0207 (0.5); 2.0160 (0.7); 2.0088 (0.9); 1.9843 (0.8); 1.7100 (0.6); 1.6993 (0.8); 1.6882 (0.7); 1.6765 (0.7); 1.6671 (0.7); -0.0002 (0.6) I.1-340: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3790 (1.0); 7.3587 (2.4); 7.3373 (2.4); 7.3133 (1.2); 7.2083 (1.2); 7.1881 (2.4); 7.1758 (2.3); 7.1555 (1.2); 7.0974 (1.4); 7.0810 (2.4); 7.0613 (1.8); 5.0604 (2.1); 4.7896 (1.6); 4.7776 (1.3); 4.7532 (3.2); 4.7154 (2.2); 4.2889 (1.8); 4.2645 (2.1); 4.2490 (1.5); 4.2378 (1.1); 4.2237 (1.8); 4.1984 (0.9); 4.1817 (0.8); 4.1674 (1.5); 4.1501 (2.4); 4.1302 (2.6); 4.1231 (2.2); 4.1178 (1.8); 4.1124 (4.6); 4.1100 (4.0); 4.1052 (5.8); 4.0945 (3.8); 4.0922 (3.6); 4.0875 (5.7); 4.0766 (1.2); 4.0698 (1.8); 3.8478 (1.2); 3.8370 (1.0); 3.8262 (1.0); 3.8149 (1.0); 3.8028 (1.0); 3.7943 (1.0); 3.7835 (1.2); 3.7373 (1.3); 3.7079 (0.8); 3.5386 (9.0); 3.1670 (1.4); 3.0621 (0.6); 3.0306 (0.9); 3.0202 (1.0); 3.0122 (1.0); 2.9884 (0.5); 2.8968 (1.2); 2.8868 (1.0); 2.8572 (1.5); 2.8464 (1.2); 2.8397 (1.0); 2.8291 (0.9); 2.7991 (1.2); 2.7893 (1.1); 2.6749 (0.8); 2.6704 (1.1); 2.6658 (0.8); 2.5986 (1.3); 2.5909 (1.7); 2.5767 (1.9); 2.5589 (0.8); 2.5367 (1.6); 2.5237 (3.4); 2.5190 (5.0); 2.5103 (68.7); 2.5057 (148.7); 2.5011 (207.4); 2.4965 (144.5); 2.4919 (63.9); 2.4622 (1.5); 2.4540 (0.5); 2.4408 (1.9); 2.4316 (1.4); 2.4177 (1.5); 2.4002 (2.0); 2.3780 (1.4); 2.3326 (1.3); 2.3280 (1.4); 2.3234 (1.3); 2.3013 (0.7); 2.2778 (1.3); 2.2653 (1.3); 2.2533 (1.8); 2.2411 (1.8); 2.2331 (1.4); 2.2120 (1.7); 2.2045 (2.0); 2.1926 (1.7); 2.1706 (1.6); 2.1607 (1.5); 2.1408 (1.6); 2.1173 (1.4); 2.0967 (1.5); 2.0629 (1.4); 1.7127 (0.6); 1.6878 (1.3); 1.6471 (2.3); 1.6150 (2.7); 1.5438 (0.9); 1.5288 (0.9); 1.5101 (0.9); 1.4921 (0.9); 1.3803 (0.5); 1.3487 (0.7); 1.2852 (0.6); 1.2149 (5.0); 1.1971 (9.6); 1.1945 (9.0); 1.1891 (4.7); 1.1822 (8.6); 1.1794 (6.6); 1.1767 (16.0); 1.1713 (7.6); 1.1645 (15.0); 1.1589 (7.6); 1.1536 (3.6); 1.1467 (6.5); 0.0080 (2.5); -0.0002 (80.2); -0.0086 (2.3) I.1-341: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1804 (1.6); 7.1723 (5.2); 7.1678 (5.4); 7.1622 (2.6); 7.1547 (1.7); 7.1427 (1.2); 7.1037 (1.2); 7.0901 (1.0); 4.6999 (0.6); 4.6894 (1.2); 4.6610 (0.6); 4.6496 (1.3); 4.0858 (1.2); 4.0455 (1.1); 3.7002 (0.5); 3.6882 (0.7); 3.6777 (0.6); 3.6680 (0.6); 3.5945 (0.7); 3.5374 (16.0); 3.4021 (20.2); 3.2054 (0.8); 3.1879 (1.0); 3.1670 (1.0); 2.7499 (0.8); 2.7401 (0.8); 2.7259 (0.5); 2.7103 (1.0); 2.7005 (1.0); 2.6791 (0.7); 2.6744 (1.1); 2.6697 (1.5); 2.6651 (1.1); 2.5544 (0.5); 2.5498 (1.2); 2.5453 (1.6); 2.5400 (1.9); 2.5353 (1.4); 2.5301 (1.0); 2.5232 (4.0); 2.5185 (6.3); 2.5098 (83.7); 2.5052 (180.3); 2.5006 (251.0); 2.4960 (176.6); 2.4915 (80.0); 2.4703 (1.8); 2.4531 (0.7); 2.4445 (0.6); 2.4306 (1.6); 2.4137 (0.8); 2.3903 (0.8); 2.3761 (0.6); 2.3322 (1.5); 2.3275 (1.6); 2.3228 (1.2); 2.3088 (0.6); 2.2974 (0.6); 2.2843 (1.0); 2.2727 (1.0); 2.2670 (0.6); 2.2599 (0.7); 2.2469 (0.9); 2.2427 (0.9); 2.2317 (2.6); 2.2193 (13.2); 2.1913 (0.6); 2.1599 (0.8); 2.1353 (0.5); 1.7192 (0.5); 1.7097 (0.5); 1.0178 (0.7); 0.9998 (1.7); 0.9819 (0.7); 0.9667 (0.8); 0.9491 (1.9); 0.9313 (0.9); 0.8833 (1.3); 0.8739 (1.1); 0.8669 (1.4); 0.8577 (0.9); 0.8342 (0.9); 0.8281 (1.0); 0.8181 (1.4); 0.8079 (1.0); 0.8022 (0.8); 0.7919 (0.7); 0.0080 (1.3); -0.0002 (47.9); -0.0085 (1.4) I.1-342: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0995 (1.0); 7.1450 (1.8); 7.1247 (7.6); 7.1120 (8.4); 7.0913 (1.8); 5.8113 (0.5); 5.7980 (1.2); 5.7852 (1.0); 5.7723 (1.3); 5.7683 (0.7); 5.7590 (0.6); 5.7550 (1.4); 5.7421 (1.1); 5.7293 (1.4); 5.7160 (0.6); 5.1332 (0.7); 5.1288 (2.2); 5.1244 (2.3); 5.1199 (0.8); 5.0902 (0.6); 5.0857 (1.9); 5.0813 (2.0); 5.0770 (0.7); 5.0631 (0.8); 5.0591 (2.3); 5.0549 (2.1); 5.0509 (0.7); 5.0374 (0.8); 5.0334 (2.1); 5.0292 (2.0); 5.0253 (0.7); 4.6760 (2.0); 4.6379 (2.2); 4.0133 (2.3); 3.9753 (2.0); 3.7254 (0.7); 3.7144 (1.0); 3.7041 (1.0); 3.6938 (1.0); 3.6831 (2.2); 3.6697 (2.9); 3.6560 (1.5); 3.6532 (1.4); 3.3111 (79.1); 3.1683 (0.6); 2.6693 (0.5); 2.5493 (1.5); 2.5383 (1.7); 2.5227 (1.4); 2.5094 (30.7); 2.5048 (67.2); 2.5003 (92.4); 2.4957 (64.5); 2.4911 (29.2); 2.3492 (1.2); 2.3310 (1.3); 2.3270 (1.5); 2.3071 (0.9); 2.2760 (16.0); 2.2557 (1.2); 2.2454 (1.3); 2.2316 (1.3); 2.2140 (0.6); 2.2035 (0.7); 2.1899 (0.7); 2.1715 (1.8); 2.1489 (1.7); 2.1368 (1.5); 2.1141 (1.5); 2.0712 (0.6); 2.0561 (0.8); 2.0435 (0.6); 2.0319 (0.7); 2.0243 (0.9); 2.0194 (0.6); 2.0050 (0.6); 2.0002 (0.8); 1.7207 (0.6); 1.7097 (0.8); 1.6997 (0.7); 1.6879 (0.6); 1.6774 (0.7) I.1-346: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5510 (1.7); 7.5480 (1.8); 7.5311 (1.9); 7.5280 (2.0); 7.2656 (1.2); 7.2618 (31.4); 7.2470 (1.8); 7.2439 (1.8); 7.2287 (1.6); 7.2255 (1.6); 7.1880 (1.7); 7.1837 (2.1); 7.1689 (1.1); 7.1647 (1.1); 7.1214 (1.6); 7.1130 (27.4); 7.1032 (1.6); 7.1016 (1.6); 7.0986 (1.4); 7.0970 (1.4); 7.0906 (0.6); 7.0834 (0.9); 7.0787 (0.8); 5.4350 (0.6); 5.2975 (2.6); 4.7045 (1.8); 4.6670 (2.0); 4.1255 (1.8); 4.0880 (1.6); 3.9441 (0.6); 3.9335 (0.8); 3.9234 (1.0); 3.9134 (0.8); 3.9027 (0.7); 3.5134 (0.8); 3.4957 (1.8); 3.4801 (2.1); 3.4636 (1.8); 3.4468 (0.8); 2.9380 (2.3); 2.9205 (4.6); 2.9030 (2.1); 2.5063 (1.3); 2.4949 (1.5); 2.4704 (1.8); 2.4587 (1.6); 2.4552 (0.9); 2.4533 (0.9); 2.4507 (0.9); 2.4309 (0.7); 2.4128 (0.9); 2.3987 (1.0); 2.3886 (1.1); 2.3746 (1.1); 2.3458 (0.6); 2.3317 (0.7); 2.3220 (16.0); 2.1953 (0.7); 2.1820 (0.5); 2.1711 (0.6); 2.1627 (0.9); 2.1579 (0.5); 2.1384 (0.7); 2.0789 (1.6); 2.0573 (1.5); 2.0427 (1.4); 2.0212 (1.3); 1.7530 (0.5); 1.7425 (0.7); 1.7325 (0.6); 1.7199 (0.6); 1.7095 (0.6); -0.0002 (9.8) I.1-347: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5189 (2.4); 7.3490 (1.5); 7.3293 (2.5); 7.3095 (2.6); 7.2916 (0.6); 7.2601 (442.4); 7.2105 (0.7); 7.1380 (0.6); 7.1156 (20.5); 7.1018 (2.4); 7.0828 (1.8); 6.9961 (4.2); 5.2334 (0.7); 4.6919 (1.9); 4.6547 (2.2); 4.1504 (2.0); 4.1128 (1.8); 3.9441 (0.7); 3.9334 (0.8); 3.9235 (1.2); 3.9141 (0.8); 3.9031 (0.7); 3.5006 (0.8); 3.4917 (0.5); 3.4828 (1.3); 3.4673 (1.3); 3.4442 (1.2); 3.4291 (1.3); 3.4113 (0.8); 2.8044 (2.1); 2.7870 (4.3); 2.7695 (2.0); 2.4961 (1.4); 2.4850 (1.4); 2.4683 (1.0); 2.4602 (1.5); 2.4488 (2.4); 2.4257 (0.8); 2.4190 (0.9); 2.4045 (1.1); 2.3948 (1.2); 2.3805 (1.3); 2.3519 (0.6); 2.3377 (0.6); 2.3210 (16.0); 2.2097 (0.8); 2.1963 (0.5); 2.1857 (0.6); 2.1776 (0.8); 2.1530 (0.7); 2.0640 (1.6); 2.0427 (1.6); 2.0278 (1.4); 2.0066 (1.8); 1.7427 (0.5); 1.7319 (0.7); 1.7222 (0.7); 1.7095 (0.7); 1.6986 (0.5); 1.5459 (33.9); 0.0080 (3.5); -0.0002 (117.5); -0.0085 (3.6) I.1-348: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9220 (1.5); 8.9005 (1.5); 7.3943 (0.6); 7.3755 (1.2); 7.3729 (1.1); 7.3581 (1.8); 7.3476 (1.7); 7.3421 (1.3); 7.3396 (1.9); 7.3353 (1.4); 7.3314 (2.3); 7.3287 (3.6); 7.3265 (3.2); 7.3209 (5.2); 7.3182 (4.8); 7.3109 (4.6); 7.3029 (5.3); 7.2623 (2.5); 7.2530 (6.0); 7.2499 (6.7); 7.2345 (5.8); 7.2314 (3.4); 7.2297 (3.5); 7.2146 (1.5); 7.2106 (1.3); 7.1988 (3.3); 7.1956 (3.5); 7.1929 (2.9); 7.1783 (0.8); 7.1586 (0.8); 7.1534 (0.6); 7.1398 (1.6); 7.1340 (1.5); 7.1246 (1.1); 7.1188 (1.3); 7.1118 (2.0); 7.1086 (2.1); 7.0920 (0.7); 6.1076 (1.8); 6.0862 (1.8); 4.7515 (1.7); 4.7124 (1.9); 4.0426 (1.6); 4.0032 (1.5); 3.7133 (0.6); 3.7027 (0.8); 3.6918 (0.7); 3.4521 (3.7); 3.1667 (16.0); 2.6434 (0.9); 2.6324 (0.9); 2.6084 (1.2); 2.5978 (1.1); 2.5712 (0.8); 2.5522 (2.2); 2.5337 (2.4); 2.5229 (1.1); 2.5095 (22.9); 2.5050 (50.2); 2.5003 (70.5); 2.4957 (49.2); 2.4911 (21.7); 2.3931 (0.7); 2.3824 (1.3); 2.3721 (0.8); 2.3602 (1.3); 2.3479 (1.5); 2.3266 (1.4); 2.2769 (0.6); 2.2660 (0.7); 2.2525 (0.9); 2.2420 (0.8); 2.2104 (0.5); 2.0605 (0.5); 2.0378 (0.5); 2.0289 (0.7); 2.0061 (0.6); 1.7644 (0.7); 1.7552 (0.7); 1.1071 (5.3); 1.0883 (12.6); 1.0694 (5.2); 0.0079 (0.8); -0.0002 (27.1); -0.0085 (0.8) I.1-349: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8214 (4.4); 7.2304 (1.4); 7.2166 (4.2); 7.1896 (0.7); 7.1710 (1.1); 7.1633 (1.3); 7.1497 (1.1); 7.1410 (1.6); 7.1228 (1.0); 5.9803 (0.5); 4.8016 (1.1); 4.7619 (1.2); 4.7287 (0.7); 4.1215 (1.2); 4.0826 (1.1); 3.7849 (0.7); 3.5782 (12.4); 3.4873 (16.0); 3.2242 (3.0); 3.1860 (0.7); 3.1658 (1.0); 2.8426 (0.6); 2.7967 (0.7); 2.6743 (1.5); 2.6699 (2.2); 2.6652 (1.4); 2.6180 (1.7); 2.6002 (2.4); 2.5820 (1.3); 2.5400 (1.9); 2.5233 (5.3); 2.5186 (7.7); 2.5099 (112.4); 2.5053 (247.0); 2.5007 (345.6); 2.4961 (240.3); 2.4915 (106.3); 2.4321 (0.8); 2.3322 (1.5); 2.3274 (2.4); 2.3228 (1.5); 2.3015 (0.8); 2.2678 (0.6); 2.1625 (0.8); 1.8416 (0.5); 1.1493 (4.0); 1.1418 (1.7); 1.1305 (9.5); 1.1230 (3.6); 1.1117 (3.9); 1.1041 (1.7); 0.0080 (3.2); -0.0002 (121.1); -0.0086 (3.4) I.1-350: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.8364 (3.1); 8.3208 (2.1); 8.3086 (2.3); 8.3010 (2.4); 8.2892 (2.0); 7.5306 (4.2); 7.5110 (4.4); 7.3301 (4.3); 7.3099 (4.9); 7.1204 (8.2); 7.1030 (6.7); 7.0791 (8.1); 7.0734 (6.0); 7.0681 (6.8); 7.0587 (5.3); 7.0559 (5.4); 7.0353 (2.8); 6.9941 (5.6); 6.9848 (3.9); 6.9741 (4.3); 6.9672 (4.2); 6.9651 (4.4); 6.9475 (2.0); 4.6162 (1.9); 4.5793 (2.5); 4.5468 (2.0); 4.5167 (0.7); 4.5041 (0.9); 4.4938 (1.7); 4.4815 (1.7); 4.4733 (1.6); 4.4610 (1.6); 4.4501 (0.8); 4.4381 (0.6); 4.0020 (2.1); 3.9639 (2.0); 3.8724 (2.2); 3.8341 (2.1); 3.6021 (2.6); 3.4973 (1.2); 3.4431 (2.0); 3.3438 (107.3); 3.1865 (1.9); 3.1743 (1.9); 3.1499 (2.6); 3.1384 (2.3); 3.0029 (1.9); 2.9956 (1.9); 2.9796 (2.0); 2.9721 (2.2); 2.9584 (1.6); 2.9430 (1.6); 2.9354 (1.5); 2.6704 (2.0); 2.6011 (2.0); 2.5058 (90.1); 2.5014 (117.7); 2.4971 (91.6); 2.4567 (3.0); 2.4445 (2.4); 2.3644 (0.7); 2.3327 (1.1); 2.3282 (1.3); 2.3111 (1.0); 2.2890 (1.8); 2.2638 (16.0); 2.2553 (15.1); 2.2268 (2.3); 2.2052 (1.2); 2.1926 (1.2); 2.1791 (1.4); 2.1739 (1.5); 2.1688 (1.7); 2.1507 (2.9); 2.1360 (2.0); 2.1264 (2.8); 2.1173 (2.2); 2.1024 (2.0); 2.0940 (2.3); 2.0853 (2.8); 2.0734 (6.2); 2.0707 (2.6); 1.9040 (0.8); 1.8913 (0.7); 1.8801 (0.8); 1.8717 (1.0); 1.8483 (0.8); 1.7845 (0.7); 1.7728 (0.6); 1.7613 (0.8); 1.7530 (0.9); 1.7295 (0.8); 1.6613 (0.7); 1.6506 (0.8); 1.6406 (0.9); 1.6286 (0.8); 1.6186 (0.7); 1.4158 (0.6); 1.4050 (0.8); 1.3948 (0.8); 1.3834 (0.8); 1.3729 (0.7); -0.0002 (6.4) I.1-351: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.7159 (1.6); 8.3393 (1.5); 8.3200 (1.5); 7.2542 (1.2); 7.2372 (3.2); 7.2324 (2.9); 7.2199 (7.4); 7.2060 (10.1); 7.1909 (3.5); 7.1834 (3.0); 7.1658 (1.5); 7.1466 (2.0); 7.1404 (1.7); 7.1308 (1.0); 7.1248 (1.0); 7.0815 (2.5); 7.0625 (1.7); 4.7171 (2.1); 4.6779 (2.4); 4.4317 (0.7); 4.4205 (1.0); 4.4071 (1.1); 4.3997 (1.0); 4.3872 (0.9); 3.9790 (2.1); 3.9390 (1.9); 3.5341 (1.0); 3.3118 (379.1); 3.1656 (0.9); 3.0778 (1.1); 3.0654 (1.2); 3.0424 (1.4); 3.0316 (1.3); 2.8309 (1.4); 2.8048 (1.5); 2.7961 (1.2); 2.7710 (1.1); 2.6790 (2.0); 2.6744 (4.0); 2.6697 (5.9); 2.6651 (4.0); 2.5940 (1.1); 2.5713 (2.7); 2.5561 (4.0); 2.5400 (4.2); 2.5232 (14.8); 2.5185 (21.6); 2.5098 (316.9); 2.5052 (689.5); 2.5006 (962.0); 2.4960 (677.0); 2.4914 (302.2); 2.4569 (1.8); 2.4473 (1.9); 2.4375 (1.4); 2.3367 (2.0); 2.3321 (4.2); 2.3274 (5.9); 2.3228 (4.6); 2.3000 (1.1); 2.2787 (1.0); 2.2577 (1.6); 2.2349 (0.9); 2.2012 (1.0); 2.1845 (1.7); 2.1774 (1.4); 2.1613 (2.0); 2.1504 (1.6); 2.1269 (1.6); 2.0731 (1.2); 1.9056 (0.8); 1.8735 (1.0); 1.8530 (0.9); 1.6915 (1.0); 1.1217 (7.0); 1.1029 (16.0); 1.0840 (6.6); 0.1459 (1.5); 0.0302 (0.6); 0.0142 (1.3); 0.0080 (14.8); 0.0063 (5.2); 0.0055 (5.7); 0.0046 (6.9); -0.0002 (475.2); -0.0060 (5.2); -0.0068 (4.5); -0.0085 (13.8); -0.0115 (1.9); -0.0140 (1.2); -0.0155 (1.1); -0.1497 (1.4) I.1-352: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9141 (1.9); 8.8929 (2.0); 7.3635 (0.5); 7.3443 (3.4); 7.3409 (3.7); 7.3371 (1.8); 7.3281 (4.4); 7.3254 (6.0); 7.3225 (7.0); 7.3199 (6.3); 7.3077 (5.1); 7.3064 (5.1); 7.3042 (6.0); 7.2603 (3.2); 7.2532 (12.8); 7.2450 (4.4); 7.2347 (7.2); 7.2332 (6.8); 7.2311 (5.7); 7.2264 (1.5); 7.2221 (0.9); 7.2180 (0.9); 7.1877 (0.6); 7.1839 (0.6); 7.1750 (0.6); 7.1712 (0.7); 7.1678 (1.0); 7.1642 (1.1); 7.1549 (1.0); 7.1517 (1.2); 7.1476 (0.7); 7.1437 (0.7); 7.1346 (0.6); 7.1313 (0.6); 7.0654 (1.1); 7.0494 (1.5); 7.0300 (0.8); 6.1062 (2.4); 6.0851 (2.4); 4.7257 (1.7); 4.6860 (2.0); 4.2208 (2.1); 4.1811 (1.8); 3.8225 (0.7); 3.8118 (1.0); 3.8016 (1.2); 3.7914 (1.0); 3.7810 (0.7); 3.3941 (5.4); 3.3384 (0.6); 3.1671 (16.0); 2.6715 (1.6); 2.6651 (0.7); 2.6606 (1.5); 2.6368 (1.7); 2.6258 (1.5); 2.5233 (1.9); 2.5186 (2.6); 2.5099 (29.6); 2.5054 (63.4); 2.5008 (87.9); 2.4962 (61.6); 2.4916 (27.1); 2.4554 (0.5); 2.4507 (0.6); 2.3843 (1.9); 2.3625 (2.1); 2.3495 (1.5); 2.3390 (1.3); 2.3276 (2.0); 2.3191 (1.4); 2.2967 (0.9); 2.2678 (0.9); 2.2547 (1.0); 2.2438 (1.3); 2.2308 (1.3); 2.2018 (0.6); 2.1891 (0.6); 2.1049 (0.8); 2.0930 (0.6); 2.0853 (0.5); 2.0811 (0.8); 2.0732 (1.2); 2.0536 (0.6); 2.0494 (0.8); 1.7786 (0.6); 1.7678 (0.9); 1.7578 (0.8); 1.7464 (0.8); 1.7362 (0.8); 0.0080 (0.8); -0.0002 (25.9); -0.0085 (0.7) I.1-353: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.7926 (1.6); 8.0592 (0.8); 8.0451 (1.6); 8.0306 (0.8); 7.5178 (2.2); 7.4980 (2.3); 7.3369 (1.9); 7.3347 (3.0); 7.3326 (2.0); 7.3167 (2.2); 7.3146 (3.6); 7.3124 (2.2); 7.1404 (2.5); 7.1205 (9.4); 7.1008 (7.9); 7.0802 (2.6); 7.0758 (1.7); 7.0728 (1.5); 7.0580 (2.0); 7.0553 (2.6); 7.0379 (1.7); 7.0350 (1.6); 6.9835 (2.0); 6.9809 (2.1); 6.9659 (1.8); 6.9636 (3.0); 6.9612 (2.2); 6.9463 (1.4); 6.9437 (1.4); 4.6629 (1.9); 4.6249 (2.2); 4.0034 (2.2); 3.9653 (2.0); 3.7194 (0.7); 3.7082 (0.9); 3.6975 (1.0); 3.6878 (0.9); 3.6770 (0.7); 3.3680 (40.1); 3.3427 (1.8); 3.3249 (2.4); 3.3102 (2.3); 3.2915 (1.2); 2.8068 (2.1); 2.7887 (3.5); 2.7704 (1.8); 2.5232 (0.8); 2.5185 (1.3); 2.5098 (22.1); 2.5053 (47.7); 2.5006 (66.6); 2.4960 (47.1); 2.4914 (20.5); 2.4733 (1.8); 2.4622 (1.6); 2.3502 (0.5); 2.3274 (1.5); 2.3082 (1.0); 2.2749 (16.0); 2.2519 (1.2); 2.2383 (1.2); 2.2279 (1.3); 2.2142 (1.3); 2.1964 (0.6); 2.1861 (0.7); 2.1724 (0.6); 2.1192 (1.6); 2.0967 (1.6); 2.0847 (1.4); 2.0621 (1.4); 2.0192 (0.8); 2.0147 (0.5); 2.0066 (0.6); 1.9951 (0.8); 1.9876 (0.9); 1.9828 (0.6); 1.9634 (0.8); 1.6758 (0.6); 1.6654 (0.8); 1.6549 (0.7); 1.6438 (0.7); 1.6331 (0.7); -0.0002 (3.3) I.1-355: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1786 (1.4); 7.1577 (4.6); 7.1378 (4.1); 7.1171 (1.4); 7.1093 (1.6); 7.0886 (0.7); 4.7069 (1.2); 4.6957 (0.6); 4.6688 (1.2); 4.1766 (2.4); 4.0614 (1.2); 4.0320 (5.9); 4.0235 (1.3); 3.9483 (0.6); 3.7206 (0.7); 3.7103 (0.6); 3.6726 (7.2); 3.6165 (16.0); 3.3883 (13.2); 3.1656 (1.7); 2.9334 (14.4); 2.8043 (0.7); 2.7949 (0.7); 2.7660 (5.8); 2.7547 (0.9); 2.6698 (1.3); 2.6650 (1.0); 2.6044 (0.9); 2.5852 (2.6); 2.5658 (2.8); 2.5472 (0.8); 2.5231 (2.1); 2.5184 (3.8); 2.5098 (71.5); 2.5052 (157.3); 2.5006 (220.5); 2.4960 (154.6); 2.4914 (69.7); 2.4725 (1.7); 2.4678 (1.5); 2.4639 (1.5); 2.4461 (1.8); 2.4240 (1.0); 2.3989 (0.8); 2.3752 (0.6); 2.3368 (1.0); 2.3319 (1.1); 2.3274 (1.4); 2.3227 (1.1); 2.2621 (0.5); 2.2497 (0.7); 2.2374 (0.8); 2.2255 (0.8); 2.0731 (1.0); 1.6253 (0.5); 1.6027 (0.5); 1.1839 (2.0); 1.1785 (4.2); 1.1650 (4.6); 1.1595 (9.6); 1.1460 (2.0); 1.1405 (4.1); 0.0080 (3.0); -0.0002 (115.4); -0.0086 (3.5); -0.0332 (0.6); -0.0506 (0.6) I.1-356: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1476 (0.6); 8.1335 (1.1); 8.1193 (0.5); 7.3701 (0.7); 7.3660 (0.8); 7.3439 (0.7); 7.1960 (0.7); 7.1921 (0.8); 7.1795 (0.8); 7.0823 (0.7); 7.0664 (1.0); 7.0468 (0.5); 4.7458 (1.1); 4.7061 (1.3); 4.2400 (1.4); 4.2005 (1.3); 3.7998 (0.7); 3.7896 (0.9); 3.7795 (0.7); 3.7691 (0.5); 3.3360 (47.4); 3.1857 (0.5); 3.1333 (1.0); 3.1148 (2.7); 3.1036 (3.3); 3.0965 (3.0); 3.0854 (2.8); 3.0781 (1.8); 3.0670 (1.0); 3.0248 (0.7); 3.0116 (1.0); 2.9984 (1.0); 2.9842 (1.1); 2.9725 (0.7); 2.5314 (1.1); 2.5197 (1.9); 2.5109 (16.0); 2.5063 (35.2); 2.5017 (49.4); 2.4970 (35.0); 2.4924 (15.3); 2.4849 (1.5); 2.3681 (0.8); 2.3490 (0.8); 2.3261 (0.8); 2.3009 (0.6); 2.2873 (0.8); 2.2768 (1.0); 2.2634 (0.9); 2.2350 (1.6); 2.2215 (0.5); 2.2137 (1.2); 2.1998 (1.0); 2.1784 (1.0); 2.1454 (0.6); 2.1214 (0.5); 2.1141 (0.7); 2.0897 (0.5); 2.0735 (1.1); 1.7614 (0.7); 1.7518 (0.9); 1.7357 (1.2); 1.7297 (1.1); 1.7165 (1.2); 1.7073 (1.0); 1.6946 (0.9); 1.1858 (7.0); 1.1677 (16.0); 1.1495 (6.7); -0.0002 (1.4) I.1-357: 1H-NMR (400.0 MHz, d6-DMSO): δ= 11.8206 (1.5); 7.2326 (1.0); 7.2291 (1.2); 7.2204 (1.9); 7.2176 (2.9); 7.2146 (4.5); 7.2017 (0.6); 7.1863 (0.9); 7.1796 (0.8); 7.1675 (1.2); 7.1602 (1.1); 7.1527 (0.6); 7.1459 (0.7); 7.1051 (1.6); 7.0867 (1.0); 4.7484 (1.5); 4.7089 (1.6); 4.0799 (1.4); 4.0407 (1.3); 3.7407 (0.5); 3.7292 (0.8); 3.7183 (0.5); 3.3981 (15.1); 3.1911 (16.0); 3.1657 (2.3); 2.7257 (0.8); 2.7156 (0.9); 2.6876 (1.1); 2.6776 (1.2); 2.6698 (0.9); 2.6652 (0.6); 2.6293 (0.6); 2.6257 (0.6); 2.6109 (1.7); 2.6069 (1.8); 2.5920 (1.9); 2.5882 (1.9); 2.5698 (0.8); 2.5401 (0.5); 2.5326 (0.5); 2.5233 (2.1); 2.5186 (3.1); 2.5099 (43.3); 2.5053 (94.4); 2.5007 (131.7); 2.4961 (92.3); 2.4915 (40.9); 2.4390 (0.6); 2.4317 (1.1); 2.4186 (0.7); 2.4092 (1.1); 2.3963 (1.2); 2.3713 (1.0); 2.3321 (0.6); 2.3275 (0.8); 2.3229 (0.6); 2.3114 (0.5); 2.3009 (0.7); 2.2869 (0.8); 2.2765 (0.8); 2.2450 (0.5); 2.2349 (0.5); 2.1669 (0.5); 2.1343 (0.6); 1.7642 (0.7); 1.7545 (0.6); 1.1511 (4.8); 1.1324 (11.3); 1.1135 (4.7); 0.0080 (2.1); 0.0064 (0.6); 0.0055 (0.7); 0.0047 (0.9); 0.0039 (1.1); -0.0002 (66.5); -0.0059 (0.7); -0.0067 (0.6); -0.0085 (1.9) I.1-358: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.7555 (1.2); 8.3581 (1.8); 8.3378 (2.1); 7.2800 (1.8); 7.2618 (4.3); 7.2440 (5.2); 7.2321 (1.6); 7.2148 (8.4); 7.2066 (5.7); 7.1980 (9.5); 7.1945 (9.5); 7.1858 (3.4); 7.1679 (1.1); 7.1602 (1.5); 7.1534 (1.1); 7.1410 (2.2); 7.1344 (1.7); 7.1258 (1.1); 7.1195 (1.0); 7.0805 (3.3); 7.0612 (2.1); 4.7139 (2.4); 4.6744 (2.7); 4.4933 (0.7); 4.4821 (0.8); 4.4687 (1.1); 4.4605 (1.1); 4.4474 (0.9); 4.4358 (0.8); 4.0230 (2.3); 3.9834 (2.3); 3.5631 (1.2); 3.3137 (221.5); 3.1655 (1.2); 3.0910 (1.2); 3.0793 (1.4); 3.0563 (1.6); 3.0448 (1.5); 2.8332 (1.6); 2.8077 (1.9); 2.7991 (1.7); 2.7739 (1.3); 2.6743 (1.7); 2.6697 (2.4); 2.6652 (1.8); 2.5827 (3.3); 2.5787 (3.4); 2.5641 (3.2); 2.5399 (3.5); 2.5231 (9.2); 2.5097 (149.9); 2.5052 (307.9); 2.5007 (417.4); 2.4961 (298.5); 2.4916 (138.7); 2.4493 (1.8); 2.4391 (1.8); 2.3947 (0.7); 2.3321 (2.3); 2.3275 (2.8); 2.3228 (2.1); 2.2929 (1.3); 2.2722 (1.7); 2.2497 (0.9); 2.2002 (1.0); 2.1898 (1.3); 2.1763 (1.4); 2.1613 (2.4); 2.1483 (1.0); 2.1385 (1.8); 2.1271 (1.9); 2.1041 (1.4); 2.0731 (1.0); 1.8053 (0.8); 1.7853 (0.8); 1.7749 (1.0); 1.7527 (0.8); 1.4425 (0.7); 1.4182 (1.0); 1.4083 (1.0); 1.1223 (7.5); 1.1035 (16.0); 1.0847 (7.1); 0.1461 (0.5); 0.0079 (6.0); -0.0002 (163.4); -0.0085 (6.2); -0.1496 (0.6) I.1-359: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.8770 (2.3); 8.8727 (2.5); 8.8665 (2.5); 8.8622 (2.5); 8.6378 (0.8); 8.6231 (1.5); 8.6083 (0.7); 8.3395 (1.4); 8.3370 (1.5); 8.3183 (1.6); 8.3159 (1.5); 7.9876 (2.6); 7.9660 (2.9); 7.7767 (2.6); 7.7733 (2.7); 7.6512 (2.2); 7.6463 (2.0); 7.6295 (1.9); 7.6245 (1.8); 7.5414 (2.5); 7.5309 (2.4); 7.5207 (2.4); 7.5102 (2.4); 7.1485 (0.7); 7.1295 (3.0); 7.1098 (8.4); 7.0980 (8.4); 7.0919 (2.0); 7.0826 (0.9); 7.0771 (1.9); 4.6895 (1.8); 4.6514 (2.0); 4.4621 (1.7); 4.4482 (3.1); 4.4343 (1.7); 4.0218 (2.0); 4.0107 (0.5); 3.9839 (1.8); 3.7722 (0.7); 3.7614 (0.9); 3.7507 (1.0); 3.7411 (0.9); 3.7304 (0.7); 3.3420 (12.1); 3.1665 (5.7); 3.1518 (0.6); 3.1344 (0.6); 3.1162 (0.6); 3.0085 (0.5); 2.7663 (3.1); 2.7570 (2.6); 2.6703 (0.6); 2.6323 (1.4); 2.6215 (1.3); 2.5974 (1.5); 2.5867 (1.4); 2.5516 (0.6); 2.5238 (1.1); 2.5191 (1.7); 2.5104 (29.4); 2.5058 (65.2); 2.5012 (91.5); 2.4966 (64.5); 2.4920 (29.0); 2.4039 (0.6); 2.3840 (0.7); 2.3614 (1.2); 2.3424 (1.0); 2.3377 (1.0); 2.3328 (0.6); 2.3280 (0.8); 2.3188 (1.1); 2.2781 (4.3); 2.2671 (16.0); 2.2583 (2.3); 2.2475 (2.1); 2.2447 (1.8); 2.2350 (1.6); 2.2270 (0.8); 2.2128 (1.5); 2.2026 (0.7); 2.1077 (0.6); 2.0885 (0.7); 2.0839 (0.5); 2.0761 (0.6); 2.0737 (0.6); 2.0695 (0.5); 2.0643 (0.7); 2.0571 (0.9); 2.0521 (0.6); 2.0376 (0.5); 2.0327 (0.7); 1.7924 (0.8); 1.7793 (0.8); 1.7687 (1.0); 1.7579 (0.7); 1.7471 (0.7); 1.7365 (0.7); 1.7260 (0.5); 1.1941 (1.0); 1.1759 (2.0); 1.1576 (1.0); 1.0701 (1.6); 1.0521 (3.6); 1.0342 (1.6); 0.0081 (1.7); -0.0002 (63.2); -0.0085 (1.9) I.1-360: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4942 (4.6); 8.4801 (9.1); 8.4658 (4.6); 7.3832 (2.4); 7.3792 (2.7); 7.3629 (9.3); 7.3527 (3.5); 7.3415 (12.6); 7.3327 (5.6); 7.3247 (10.1); 7.3197 (6.8); 7.3126 (3.3); 7.3030 (5.2); 7.2408 (6.2); 7.2344 (6.5); 7.2173 (7.2); 7.2146 (7.8); 7.2109 (8.0); 7.2082 (8.1); 7.2046 (4.1); 7.2005 (3.8); 7.1912 (9.3); 7.1846 (12.3); 7.1809 (6.8); 7.1716 (5.7); 7.1682 (6.4); 7.1643 (4.0); 7.1602 (3.7); 7.1512 (3.2); 7.1478 (3.4); 7.0717 (8.1); 7.0690 (10.1); 7.0655 (8.6); 7.0505 (15.9); 7.0481 (16.0); 7.0441 (10.6); 7.0417 (9.1); 7.0326 (4.9); 7.0292 (6.7); 7.0267 (5.3); 7.0226 (3.9); 7.0202 (3.8); 4.7280 (9.4); 4.6882 (10.8); 4.2834 (0.8); 4.2693 (1.0); 4.2412 (12.7); 4.2308 (13.0); 4.2180 (13.0); 4.2029 (1.3); 4.1780 (10.4); 3.8238 (3.0); 3.8131 (5.3); 3.8026 (7.3); 3.7924 (8.9); 3.7824 (8.3); 3.7719 (7.4); 3.7608 (6.2); 3.7323 (6.0); 2.6765 (1.3); 2.6719 (1.8); 2.6673 (1.3); 2.5923 (7.7); 2.5810 (7.7); 2.5573 (8.8); 2.5458 (8.3); 2.5254 (5.2); 2.5207 (7.8); 2.5119 (100.3); 2.5074 (218.4); 2.5028 (303.3); 2.4982 (214.5); 2.4936 (95.6); 2.4578 (1.7); 2.4532 (1.8); 2.4485 (1.1); 2.3866 (2.1); 2.3670 (2.9); 2.3444 (6.6); 2.3342 (2.0); 2.3249 (7.8); 2.3021 (5.3); 2.2789 (5.6); 2.2719 (10.6); 2.2657 (7.1); 2.2549 (8.9); 2.2503 (10.8); 2.2417 (8.7); 2.2369 (11.2); 2.2238 (3.0); 2.2148 (9.5); 2.2000 (3.8); 2.1410 (2.6); 2.1216 (4.7); 2.1174 (3.0); 2.1094 (3.5); 2.1021 (3.0); 2.0977 (4.3); 2.0900 (5.8); 2.0857 (3.6); 2.0783 (2.2); 2.0704 (3.2); 2.0660 (4.3); 2.0466 (1.8); 1.7666 (2.4); 1.7540 (3.6); 1.7432 (5.0); 1.7331 (4.3); 1.7217 (4.2); 1.7114 (4.4); 1.7009 (2.6); 1.6878 (1.9); 0.0080 (3.5); -0.0002 (114.0); -0.0085 (3.3); -0.0499 (0.6) I.1-361: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.4717 (6.2); 10.4673 (6.3); 8.0564 (2.9); 8.0424 (6.0); 8.0283 (3.0); 7.3806 (1.5); 7.3767 (1.6); 7.3601 (3.2); 7.3561 (3.5); 7.3503 (1.9); 7.3404 (2.3); 7.3341 (3.5); 7.3302 (3.1); 7.3140 (1.9); 7.3101 (1.9); 7.2094 (1.9); 7.2055 (2.1); 7.1966 (2.0); 7.1929 (2.5); 7.1894 (3.6); 7.1858 (4.0); 7.1766 (3.5); 7.1733 (4.0); 7.1692 (2.4); 7.1652 (2.4); 7.1563 (2.0); 7.1528 (2.2); 7.1191 (14.0); 7.1181 (14.5); 7.0977 (15.2); 7.0966 (16.0); 7.0758 (3.8); 7.0597 (5.1); 7.0565 (4.9); 7.0403 (2.7); 7.0115 (10.8); 7.0060 (10.6); 6.8070 (12.8); 6.8013 (13.5); 6.5921 (8.9); 6.5864 (8.4); 6.5706 (8.2); 6.5650 (8.0); 4.7455 (5.8); 4.7058 (6.7); 4.2352 (7.3); 4.1955 (6.5); 3.8190 (9.1); 3.8084 (10.1); 3.7979 (10.6); 3.7878 (10.7); 3.7778 (9.2); 3.7673 (7.4); 3.7565 (5.4); 3.5746 (0.7); 3.3148 (0.8); 3.3007 (2.5); 3.2824 (5.1); 3.2689 (5.6); 3.2574 (5.1); 3.2397 (2.7); 3.2252 (0.8); 3.1692 (2.7); 2.7061 (6.9); 2.6876 (12.8); 2.6693 (6.5); 2.5408 (0.7); 2.5275 (4.9); 2.5244 (3.5); 2.5192 (4.6); 2.5108 (55.1); 2.5062 (120.4); 2.5016 (168.8); 2.4969 (119.4); 2.4924 (58.0); 2.4813 (6.4); 2.3951 (1.4); 2.3754 (1.9); 2.3722 (2.0); 2.3529 (4.1); 2.3331 (4.6); 2.3190 (0.9); 2.3106 (3.1); 2.2751 (3.0); 2.2618 (3.7); 2.2510 (4.6); 2.2378 (4.4); 2.2334 (2.2); 2.2200 (1.9); 2.2089 (3.0); 2.2036 (6.0); 2.1962 (2.9); 2.1820 (5.6); 2.1688 (4.8); 2.1472 (4.7); 2.1271 (1.6); 2.1076 (2.8); 2.1034 (1.9); 2.0953 (2.2); 2.0881 (1.9); 2.0836 (2.7); 2.0760 (3.6); 2.0730 (6.9); 2.0644 (1.4); 2.0564 (2.0); 2.0519 (2.6); 2.0324 (1.2); 1.7572 (1.5); 1.7447 (2.2); 1.7339 (3.0); 1.7235 (2.6); 1.7124 (2.6); 1.7020 (2.7); 1.6912 (1.6); 1.6784 (1.2); -0.0002 (6.7) I.1-362: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9622 (0.5); 7.1434 (0.9); 7.1232 (3.1); 7.1082 (3.4); 7.1027 (0.6); 7.0875 (0.9); 4.6629 (0.8); 4.6249 (0.9); 4.0121 (0.9); 3.9741 (0.8); 3.5746 (16.0); 3.5056 (1.8); 3.0376 (1.0); 3.0337 (0.8); 3.0234 (0.8); 3.0196 (1.0); 2.5105 (3.6); 2.5060 (8.0); 2.5013 (11.6); 2.4967 (7.8); 2.4921 (3.7); 2.4666 (0.7); 2.4556 (0.7); 2.3072 (1.3); 2.3019 (0.5); 2.2885 (2.7); 2.2751 (6.9); 2.2702 (2.6); 2.2562 (0.5); 2.2460 (0.6); 2.2320 (0.5); 2.1100 (0.7); 2.0875 (0.7); 2.0753 (0.6); 2.0528 (0.6); 1.6560 (0.6); 1.6388 (1.2); 1.6204 (1.6); 1.6024 (1.0); -0.0002 (0.6) I.1-363: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1990 (1.9); 9.1917 (1.8); 8.3022 (0.5); 8.2973 (0.5); 7.1311 (0.9); 7.1107 (2.3); 7.0920 (1.7); 7.0748 (1.7); 7.0547 (0.7); 6.9941 (1.7); 6.9734 (2.0); 6.6563 (1.4); 6.6509 (0.6); 6.6469 (1.5); 6.6408 (0.7); 6.6350 (1.3); 6.6304 (0.6); 6.6255 (1.3); 3.3215 (48.3); 3.2978 (2.4); 2.5101 (7.2); 2.5055 (15.5); 2.5009 (21.9); 2.4963 (15.2); 2.4917 (7.0); 2.4665 (0.6); 2.2688 (4.5); 2.0851 (3.3); 2.0725 (2.1); 1.3289 (16.0); 1.3189 (15.4); -0.0002 (16.2); -0.0028 (0.9) I.1-365: 1H-NMR (400.1 MHz, CDCl3): δ= 7.5206 (1.2); 7.3094 (0.6); 7.2903 (0.4); 7.2618 (208.0); 7.2093 (0.4); 7.1312 (0.4); 7.1177 (0.8); 7.1064 (1.5); 7.0961 (1.0); 7.0888 (1.6); 7.0817 (1.7); 7.0728 (1.0); 7.0631 (6.2); 7.0529 (5.7); 7.0444 (2.2); 7.0395 (1.8); 6.9978 (1.2); 4.9135 (2.3); 4.8746 (2.5); 4.7178 (1.0); 4.7067 (1.0); 4.6906 (2.0); 4.6796 (2.0); 4.6635 (1.1); 4.6521 (1.0); 4.2430 (3.1); 4.2044 (2.9); 3.8931 (0.5); 3.8831 (0.9); 3.8726 (1.3); 3.8623 (1.5); 3.8510 (1.3); 3.8402 (0.9); 3.8304 (0.5); 2.7332 (2.0); 2.7239 (2.0); 2.6955 (2.5); 2.6862 (2.4); 2.5623 (0.5); 2.5439 (0.7); 2.5389 (0.7); 2.5202 (1.8); 2.5012 (1.5); 2.4963 (1.3); 2.4776 (1.4); 2.4394 (1.2); 2.4252 (1.4); 2.4149 (1.7); 2.4020 (4.0); 2.3796 (2.7); 2.3720 (1.2); 2.3647 (2.3); 2.3581 (1.1); 2.3420 (2.0); 2.2946 (0.7); 2.2754 (1.1); 2.2699 (0.7); 2.2623 (0.9); 2.2560 (0.8); 2.2515 (0.9); 2.2432 (1.2); 2.2376 (0.8); 2.2323 (0.5); 2.2234 (0.8); 2.2184 (0.9); 2.1989 (0.5); 1.9539 (1.2); 1.9239 (1.3); 1.9009 (0.6); 1.8883 (0.9); 1.8762 (1.2); 1.8663 (1.0); 1.8530 (1.0); 1.8429 (1.1); 1.8321 (0.8); 1.8185 (0.9); 1.8074 (1.0); 1.8008 (1.0); 1.7898 (1.4); 1.7837 (1.2); 1.7725 (1.0); 1.7654 (1.0); 1.7544 (0.4); 1.7487 (0.4); 1.6932 (2.4); 1.6669 (2.4); 1.6610 (2.5); 1.6525 (1.6); 1.6058 (0.5); 1.5582 (142.5); 1.5209 (0.4); 1.5050 (0.7); 1.4818 (1.0); 1.4741 (1.0); 1.4660 (0.9); 1.4361 (0.5); 1.4284 (0.4); 1.3964 (0.5); 1.3897 (0.9); 1.3819 (0.5); 1.3595 (1.5); 1.3388 (0.7); 1.3309 (1.0); 1.3237 (0.6); 1.0960 (0.4); 1.0857 (0.5); 1.0594 (1.1); 1.0533 (1.3); 1.0283 (1.5); 1.0213 (1.2); 0.9961 (1.6); 0.9665 (2.3); 0.9381 (2.5); 0.9105 (15.1); 0.8991 (16.0); 0.8943 (14.6); 0.8818 (14.2); 0.8477 (1.0); 0.8190 (0.5); 0.7477 (13.4); 0.7303 (12.9); 0.1460 (0.4); 0.0074 (4.4) I.1-366: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1490 (2.2); 7.1288 (7.6); 7.1149 (7.5); 7.1000 (2.1); 7.0946 (1.9); 7.0767 (1.2); 5.0631 (1.0); 5.0498 (1.0); 4.7472 (1.2); 4.7091 (1.6); 4.7004 (1.1); 4.6620 (1.4); 4.2185 (1.2); 4.2132 (1.2); 4.2007 (1.3); 4.1955 (1.4); 4.1779 (0.6); 4.1690 (0.9); 4.1514 (1.4); 4.1337 (1.1); 4.1266 (1.1); 4.1156 (1.7); 4.1089 (2.1); 4.1059 (1.8); 4.0977 (3.6); 4.0912 (1.9); 4.0882 (1.7); 4.0799 (3.3); 4.0706 (1.4); 4.0621 (1.0); 4.0352 (1.3); 3.9976 (1.0); 3.9528 (0.5); 3.7401 (0.5); 3.7273 (0.8); 3.7173 (1.1); 3.7077 (1.1); 3.6979 (0.7); 3.6841 (0.8); 3.3160 (77.1); 3.2923 (2.8); 3.0160 (3.0); 2.9754 (0.7); 2.9687 (0.6); 2.8546 (0.6); 2.8446 (0.5); 2.8149 (0.7); 2.8037 (0.8); 2.7923 (0.5); 2.7622 (0.8); 2.7531 (0.8); 2.6698 (0.5); 2.5401 (0.5); 2.5233 (2.0); 2.5186 (2.7); 2.5099 (31.4); 2.5054 (67.6); 2.5007 (94.4); 2.4961 (65.4); 2.4916 (29.4); 2.4774 (1.0); 2.4665 (0.5); 2.4616 (0.8); 2.4511 (0.5); 2.4380 (0.7); 2.4300 (0.6); 2.4132 (1.2); 2.3902 (1.4); 2.3739 (1.0); 2.3509 (0.9); 2.3324 (0.6); 2.3276 (0.6); 2.2742 (16.0); 2.2522 (1.1); 2.2408 (1.3); 2.2280 (1.5); 2.2106 (0.6); 2.1990 (0.8); 2.1865 (0.8); 2.1312 (0.5); 2.1123 (0.8); 2.0922 (1.4); 2.0874 (1.3); 2.0729 (1.0); 2.0648 (1.0); 2.0550 (1.1); 2.0452 (1.0); 1.6554 (0.7); 1.6346 (1.6); 1.6240 (1.6); 1.6129 (1.5); 1.6006 (1.6); 1.5927 (1.6); 1.5830 (1.3); 1.5691 (1.2); 1.5377 (0.9); 1.5277 (0.6); 1.5029 (0.5); 1.4921 (0.5); 1.2430 (3.0); 1.2253 (6.4); 1.2178 (2.6); 1.2075 (3.7); 1.2001 (5.5); 1.1905 (4.5); 1.1862 (2.9); 1.1823 (3.3); 1.1729 (10.3); 1.1685 (4.4); 1.1558 (9.8); 1.1509 (2.3); 1.1382 (3.8); -0.0002 (7.6) I.1-367: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2132 (1.0); 8.1942 (1.0); 7.1773 (0.7); 7.1704 (0.5); 7.1568 (2.4); 7.1495 (0.9); 7.1391 (2.4); 7.1185 (0.7); 7.1101 (0.6); 6.9512 (1.0); 6.9322 (1.0); 4.7072 (0.6); 4.6691 (0.6); 4.0642 (0.6); 4.0583 (0.9); 3.9375 (2.1); 3.3166 (4.3); 3.1608 (16.0); 3.1228 (1.4); 3.1045 (4.6); 3.0863 (4.7); 3.0681 (1.4); 2.9165 (4.6); 2.7642 (2.0); 2.6699 (0.6); 2.6651 (0.6); 2.6045 (0.5); 2.5851 (1.4); 2.5663 (1.2); 2.5451 (0.5); 2.5233 (1.5); 2.5186 (2.2); 2.5100 (27.5); 2.5054 (59.0); 2.5008 (81.8); 2.4962 (57.2); 2.4916 (25.3); 2.4679 (0.6); 2.4548 (0.6); 2.4501 (1.0); 2.4456 (1.2); 2.4409 (0.7); 2.3276 (0.7); 1.1919 (5.0); 1.1830 (2.0); 1.1787 (2.1); 1.1737 (10.8); 1.1641 (4.0); 1.1598 (4.0); 1.1554 (5.0); 1.1451 (1.7); 1.1408 (1.7); 0.0080 (1.4); -0.0002 (43.6); -0.0085 (1.2); -0.0507 (0.5) I.1-368: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4192 (1.8); 7.4014 (4.6); 7.3828 (3.9); 7.3560 (1.6); 7.3394 (1.5); 7.1810 (8.6); 7.1773 (12.9); 7.1721 (5.7); 7.1598 (13.0); 7.1570 (16.0); 7.1430 (1.7); 7.1296 (1.5); 7.1241 (1.5); 7.1112 (1.9); 6.9189 (1.5); 6.9024 (1.3); 4.5229 (1.2); 4.4835 (1.3); 4.0986 (0.6); 4.0589 (0.5); 3.9052 (1.4); 3.8662 (1.2); 3.7476 (1.3); 3.7376 (1.5); 3.7286 (1.3); 3.0944 (9.2); 2.5236 (0.8); 2.5188 (1.1); 2.5102 (15.9); 2.5056 (34.6); 2.5010 (48.4); 2.4964 (34.3); 2.4918 (15.6); 2.4045 (1.0); 2.3661 (1.1); 2.3279 (0.5); 2.2610 (1.2); 2.2230 (3.4); 2.2109 (2.6); 2.1587 (13.1); 2.1216 (1.4); 2.1108 (1.6); 2.0909 (1.6); 2.0730 (2.2); 2.0381 (0.7); 1.6701 (1.0); -0.0002 (15.4) I.1-369: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.9728 (8.7); 7.5405 (10.7); 7.5377 (13.4); 7.5329 (4.1); 7.5188 (15.3); 7.5163 (13.5); 7.3672 (1.5); 7.3632 (1.6); 7.3467 (3.1); 7.3426 (3.5); 7.3366 (1.9); 7.3270 (2.3); 7.3207 (3.6); 7.3165 (3.3); 7.3089 (2.2); 7.3044 (12.7); 7.2995 (5.3); 7.2857 (16.0); 7.2835 (13.3); 7.2690 (4.2); 7.2645 (12.0); 7.2595 (1.5); 7.2069 (1.9); 7.2030 (2.0); 7.1942 (1.9); 7.1903 (2.3); 7.1870 (3.6); 7.1833 (3.8); 7.1742 (3.5); 7.1709 (3.9); 7.1666 (2.4); 7.1628 (2.3); 7.1538 (2.0); 7.1504 (2.2); 7.1247 (0.5); 7.0986 (3.6); 7.0826 (4.8); 7.0631 (2.7); 7.0569 (3.8); 7.0540 (6.0); 7.0511 (3.5); 7.0355 (9.6); 7.0199 (2.6); 7.0171 (4.4); 7.0142 (2.4); 4.7617 (5.5); 4.7220 (6.4); 4.2976 (7.0); 4.2577 (5.9); 3.9367 (1.1); 3.9255 (2.4); 3.9154 (3.2); 3.9052 (4.2); 3.8954 (3.2); 3.8852 (2.4); 3.8743 (1.1); 3.3566 (0.6); 3.3226 (130.9); 3.1676 (0.9); 2.7690 (4.9); 2.7574 (5.0); 2.7327 (6.1); 2.7211 (5.9); 2.6752 (0.8); 2.6705 (1.1); 2.6658 (0.8); 2.5448 (0.7); 2.5407 (1.2); 2.5356 (0.9); 2.5307 (0.8); 2.5240 (2.6); 2.5193 (4.1); 2.5106 (58.5); 2.5060 (126.9); 2.5014 (176.7); 2.4968 (123.5); 2.4922 (54.7); 2.4742 (0.9); 2.4643 (6.0); 2.4431 (6.2); 2.4281 (6.3); 2.4069 (8.7); 2.3879 (3.6); 2.3841 (3.3); 2.3655 (2.9); 2.3328 (1.0); 2.3280 (1.7); 2.3239 (3.5); 2.3110 (3.4); 2.3001 (4.6); 2.2871 (4.5); 2.2827 (1.9); 2.2700 (1.1); 2.2583 (2.6); 2.2462 (2.8); 2.2323 (2.1); 2.2139 (3.1); 2.2086 (1.4); 2.2018 (2.3); 2.1949 (1.9); 2.1898 (2.2); 2.1828 (3.6); 2.1778 (2.0); 2.1710 (1.2); 2.1633 (2.0); 2.1586 (2.5); 2.1393 (1.1); 2.0736 (2.2); 1.8493 (1.4); 1.8381 (2.3); 1.8269 (3.0); 1.8167 (2.5); 1.8073 (2.7); 1.7956 (2.6); 1.7844 (1.7); 1.7717 (1.1); 0.0079 (0.6); -0.0002 (21.0); -0.0085 (0.6) I.1-370: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2326 (0.8); 7.2139 (1.8); 7.2083 (0.9); 7.1952 (1.1); 7.1895 (0.6); 7.0805 (1.4); 7.0614 (1.1); 7.0277 (1.6); 7.0162 (1.0); 6.9972 (1.4); 4.7011 (1.0); 4.6839 (0.5); 4.6629 (1.2); 4.6455 (0.5); 4.1772 (2.4); 4.0732 (1.2); 4.0333 (7.0); 4.0056 (0.6); 3.9673 (0.5); 3.7694 (1.1); 3.7568 (1.4); 3.7470 (1.7); 3.7370 (1.8); 3.7272 (1.6); 3.6884 (0.8); 3.6696 (7.6); 3.6168 (16.0); 2.9361 (14.5); 2.8063 (0.6); 2.7967 (0.7); 2.7660 (6.1); 2.7566 (0.9); 2.5232 (1.0); 2.5185 (1.4); 2.5099 (21.0); 2.5053 (45.7); 2.5007 (63.5); 2.4961 (44.5); 2.4916 (20.3); 2.4699 (1.1); 2.4527 (0.9); 2.4295 (0.9); 2.4060 (0.6); 2.3276 (0.6); 2.2858 (12.7); 2.2650 (0.6); 2.2529 (0.7); 2.2406 (0.7); 2.1257 (0.5); 2.0935 (0.6); -0.0002 (7.9) I.1-371: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.5439 (0.9); 8.2863 (1.7); 8.2662 (1.7); 7.2246 (1.6); 7.2209 (2.0); 7.2133 (3.2); 7.2098 (5.0); 7.2070 (6.6); 7.1950 (1.0); 7.1772 (1.2); 7.1704 (1.1); 7.1584 (1.9); 7.1510 (1.8); 7.1445 (1.2); 7.1368 (1.2); 7.1148 (2.6); 7.0968 (1.4); 4.7613 (2.3); 4.7220 (2.5); 4.2514 (0.6); 4.2367 (0.8); 4.2304 (0.9); 4.2168 (1.0); 4.2077 (0.7); 4.1931 (0.7); 4.0911 (2.1); 4.0518 (1.9); 3.7082 (0.5); 3.6963 (0.8); 3.6868 (1.0); 3.6771 (0.9); 3.6662 (0.6); 3.3163 (112.8); 3.2937 (12.0); 2.6791 (0.6); 2.6744 (1.2); 2.6698 (1.7); 2.6651 (1.2); 2.6274 (1.1); 2.6088 (3.2); 2.5902 (3.5); 2.5716 (1.5); 2.5400 (1.1); 2.5233 (4.5); 2.5186 (6.6); 2.5099 (91.1); 2.5053 (199.1); 2.5007 (277.2); 2.4961 (194.8); 2.4915 (86.8); 2.4701 (2.0); 2.4555 (0.9); 2.4506 (0.9); 2.4321 (0.6); 2.4094 (1.0); 2.3890 (1.0); 2.3674 (1.4); 2.3448 (0.8); 2.3368 (0.7); 2.3321 (1.3); 2.3275 (1.7); 2.3229 (1.3); 2.2908 (1.7); 2.2834 (1.0); 2.2693 (1.9); 2.2573 (2.0); 2.2482 (1.3); 2.2418 (1.2); 2.2350 (1.4); 2.2164 (0.8); 2.2062 (0.8); 2.0852 (1.3); 2.0731 (1.7); 2.0665 (0.7); 2.0558 (0.6); 2.0483 (1.0); 2.0341 (0.9); 2.0109 (0.8); 1.7879 (0.6); 1.7737 (0.6); 1.7648 (0.9); 1.7546 (0.9); 1.6219 (0.6); 1.6013 (0.7); 1.5861 (0.7); 1.5123 (1.4); 1.5013 (2.0); 1.4876 (2.4); 1.4788 (1.5); 1.4653 (1.2); 1.1557 (0.6); 1.1419 (6.8); 1.1232 (16.0); 1.1043 (6.6); 0.8912 (9.9); 0.8748 (9.6); 0.8232 (10.0); 0.8069 (9.7); 0.0119 (0.6); 0.0111 (0.7); 0.0103 (0.8); 0.0080 (5.0); 0.0064 (1.6); 0.0055 (1.8); 0.0047 (2.2); 0.0038 (3.0); -0.0002 (156.6); -0.0059 (1.6); -0.0067 (1.4); -0.0085 (4.4); -0.0107 (0.8); -0.0114 (0.7); -0.1496 (0.5) I.1-372: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0190 (4.2); 8.0107 (4.1); 7.3768 (1.6); 7.3555 (3.4); 7.3353 (3.5); 7.3136 (1.8); 7.2048 (2.1); 7.1887 (3.4); 7.1851 (3.6); 7.1725 (3.7); 7.1522 (1.7); 7.0668 (3.4); 7.0512 (4.6); 7.0316 (2.5); 4.7196 (5.5); 4.6795 (6.3); 4.5964 (1.8); 4.2215 (7.1); 4.1818 (6.1); 4.0942 (1.0); 4.0309 (1.0); 3.9862 (1.0); 3.8929 (1.0); 3.8003 (2.4); 3.7911 (3.8); 3.7806 (4.6); 3.7702 (3.3); 3.7593 (2.7); 3.6865 (1.2); 3.5959 (3.2); 3.5560 (2.5); 3.5425 (2.1); 3.5259 (5.2); 3.5014 (2.1); 3.4917 (8.8); 3.4842 (9.0); 3.4456 (111.1); 3.4280 (96.8); 3.3529 (39.9); 3.3315 (6.4); 3.3131 (7.5); 3.2917 (13.7); 3.2753 (18.0); 3.2549 (3.8); 3.2479 (4.7); 3.1952 (5.0); 3.1853 (3.0); 3.1696 (16.0); 3.1419 (1.6); 3.0478 (0.9); 2.8950 (0.9); 2.7713 (2.1); 2.7590 (1.5); 2.6780 (5.8); 2.6734 (8.2); 2.6688 (6.0); 2.5906 (1.9); 2.5808 (2.7); 2.5723 (5.5); 2.5624 (9.0); 2.5595 (9.7); 2.5548 (11.9); 2.5504 (5.3); 2.5433 (5.4); 2.5377 (5.8); 2.5334 (5.9); 2.5267 (19.1); 2.5220 (28.5); 2.5134 (461.3); 2.5088 (1013.8); 2.5042 (1430.8); 2.4996 (1017.2); 2.4950 (462.7); 2.4676 (3.4); 2.4605 (3.6); 2.4568 (3.3); 2.4459 (1.9); 2.4224 (6.9); 2.4106 (6.3); 2.3923 (3.1); 2.3689 (2.2); 2.3504 (4.6); 2.3402 (3.6); 2.3356 (7.2); 2.3310 (12.5); 2.3265 (9.4); 2.3079 (3.7); 2.2841 (3.3); 2.2706 (3.6); 2.2599 (4.9); 2.2470 (4.4); 2.2286 (1.9); 2.2181 (2.4); 2.2050 (2.6); 2.1468 (6.6); 2.1257 (7.8); 2.1181 (3.0); 2.1115 (6.6); 2.0984 (3.7); 2.0905 (5.7); 2.0717 (4.9); 2.0555 (1.4); 1.7468 (1.4); 1.7345 (2.2); 1.7237 (3.0); 1.7105 (2.4); 1.7019 (2.5); 1.6917 (2.8); 1.6809 (1.7); 1.6677 (1.4); 1.1413 (1.0); 1.0689 (1.0); 1.0507 (1.7); 1.0303 (2.2); 0.6097 (3.2); 0.5973 (8.5); 0.5925 (11.0); 0.5804 (10.8); 0.5746 (9.4); 0.5630 (4.3); 0.3484 (3.7); 0.3376 (10.8); 0.3311 (8.9); 0.3276 (9.6); 0.3219 (9.2); 0.3107 (3.4); 0.1460 (1.2); 0.0503 (2.1); 0.0080 (8.6); -0.0002 (340.1); -0.0085 (11.2); -0.0486 (0.9); -0.1497 (1.1) I.1-373: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0075 (1.3); 7.2288 (1.4); 7.2099 (3.2); 7.1912 (2.0); 7.0792 (1.9); 7.0591 (1.4); 7.0154 (2.9); 7.0027 (1.8); 6.9821 (1.3); 4.6598 (2.1); 4.6215 (2.3); 4.0119 (2.2); 3.9732 (2.0); 3.7250 (0.9); 3.7141 (1.1); 3.3164 (183.3); 3.1923 (0.8); 2.7808 (1.8); 2.6744 (1.9); 2.6696 (2.7); 2.6653 (1.8); 2.6002 (1.1); 2.5910 (0.9); 2.5820 (1.6); 2.5722 (1.9); 2.5629 (1.4); 2.5539 (1.5); 2.5384 (2.6); 2.5339 (4.0); 2.5291 (4.5); 2.5233 (8.8); 2.5185 (12.2); 2.5099 (160.8); 2.5053 (346.8); 2.5007 (479.5); 2.4961 (331.8); 2.4915 (146.3); 2.4557 (2.4); 2.4455 (1.9); 2.4213 (2.0); 2.4099 (2.0); 2.3321 (2.1); 2.3274 (3.0); 2.3226 (2.9); 2.2854 (16.0); 2.2673 (1.2); 2.2569 (1.4); 2.2434 (1.4); 2.2145 (0.7); 2.0770 (1.8); 2.0550 (1.8); 2.0426 (1.8); 2.0201 (1.9); 1.6831 (0.9); 1.6731 (0.8); 1.1752 (1.0); 1.1066 (1.3); 1.0883 (0.7); 0.8280 (0.8); 0.6104 (1.3); 0.5985 (3.1); 0.5936 (3.7); 0.5813 (3.2); 0.5756 (2.8); 0.5644 (1.0); 0.3578 (1.2); 0.3471 (3.3); 0.3405 (3.0); 0.3372 (2.8); 0.3310 (2.7); 0.3211 (0.9); 0.0080 (2.3); -0.0002 (81.5); -0.0086 (2.3) I.1-374: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1530 (1.0); 8.1492 (0.6); 8.1394 (0.6); 8.1355 (1.0); 7.1851 (0.9); 7.1437 (0.7); 7.1395 (0.6); 6.7515 (1.0); 6.7476 (0.6); 6.7380 (0.6); 6.7340 (0.9); 3.0597 (0.9); 3.0408 (16.0); 3.0233 (2.9); 3.0052 (0.9); 2.5102 (6.6); 2.5057 (14.2); 2.5011 (19.8); 2.4965 (13.9); 2.4919 (6.2); 1.1950 (4.4); 1.1777 (4.4); 1.1695 (3.7); 1.1513 (7.6); 1.1331 (3.4); 0.8479 (1.9); 0.8306 (2.9); 0.8123 (0.6); -0.0002 (8.2) I.1-375: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5564 (0.5); 7.5203 (2.9); 7.5147 (3.6); 7.4955 (6.1); 7.4556 (4.1); 7.4367 (8.0); 7.4166 (12.5); 7.3808 (6.6); 7.3619 (3.7); 7.3118 (0.8); 7.3013 (0.5); 7.2798 (0.9); 7.2734 (1.3); 7.2726 (1.4); 7.2710 (1.8); 7.2702 (1.9); 7.2686 (2.7); 7.2678 (3.1); 7.2615 (294.4); 7.2573 (3.3); 7.2564 (2.0); 7.2556 (1.4); 7.2548 (0.8); 7.2540 (0.6); 7.2532 (0.6); 7.1258 (1.1); 7.1163 (1.7); 7.1098 (1.6); 7.1010 (4.0); 7.0884 (3.0); 7.0860 (2.8); 7.0823 (3.2); 7.0756 (4.0); 7.0661 (2.0); 7.0621 (2.4); 7.0580 (4.6); 7.0543 (8.4); 7.0468 (12.5); 7.0442 (7.7); 7.0381 (10.8); 7.0310 (4.2); 7.0276 (5.9); 7.0160 (1.0); 7.0097 (0.7); 6.9974 (1.6); 5.4611 (2.5); 4.8482 (5.3); 4.8445 (5.1); 4.8095 (6.0); 4.8058 (5.8); 4.2384 (7.4); 4.1997 (6.6); 3.9526 (1.2); 3.9416 (2.5); 3.9308 (3.2); 3.9203 (3.6); 3.9105 (3.2); 3.8996 (2.6); 3.8885 (1.3); 3.5985 (0.8); 3.5808 (1.9); 3.5646 (3.4); 3.5467 (5.9); 3.5316 (7.1); 3.5144 (6.8); 3.4997 (5.4); 3.4825 (3.3); 3.4656 (1.7); 3.4484 (0.8); 2.9086 (0.5); 2.8906 (8.7); 2.8730 (16.0); 2.8554 (7.1); 2.6016 (5.3); 2.5908 (5.3); 2.5654 (6.2); 2.5546 (6.0); 2.5311 (1.1); 2.5120 (1.4); 2.5089 (1.3); 2.4886 (3.8); 2.4691 (3.6); 2.4657 (3.4); 2.4458 (3.4); 2.4375 (3.9); 2.4228 (4.5); 2.4133 (5.2); 2.3988 (5.3); 2.3945 (1.9); 2.3797 (1.5); 2.3701 (2.2); 2.3557 (2.1); 2.2713 (1.9); 2.2521 (3.0); 2.2474 (1.9); 2.2385 (2.4); 2.2330 (2.0); 2.2280 (2.6); 2.2195 (3.4); 2.2144 (2.2); 2.2091 (1.5); 2.2002 (2.1); 2.1951 (2.6); 2.1761 (1.4); 2.1393 (6.7); 2.1170 (6.5); 2.1031 (5.9); 2.0808 (5.7); 2.0067 (1.1); 1.8070 (1.7); 1.7956 (1.9); 1.7927 (2.2); 1.7816 (2.4); 1.7722 (2.5); 1.7689 (2.1); 1.7627 (1.9); 1.7595 (2.5); 1.7484 (2.2); 1.7393 (1.7); 1.7361 (1.5); 1.7246 (1.3); 0.0079 (2.9); 0.0062 (1.0); -0.0002 (96.0); -0.0061 (0.7); -0.0069 (0.6); -0.0085 (2.6) I.1-376: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2689 (0.6); 8.2555 (1.2); 8.2411 (0.6); 7.3663 (0.8); 7.3443 (0.8); 7.1964 (0.8); 7.1928 (0.9); 7.1804 (0.9); 7.1724 (0.6); 7.1601 (0.5); 7.0780 (1.0); 7.0617 (1.2); 7.0427 (0.6); 4.7388 (1.3); 4.6990 (1.5); 4.2424 (1.6); 4.2027 (1.4); 3.8203 (0.5); 3.8098 (0.7); 3.8001 (0.9); 3.7900 (0.8); 3.7797 (0.6); 3.3844 (0.9); 3.3674 (2.2); 3.3329 (82.6); 3.2829 (0.9); 3.1617 (2.1); 3.1496 (2.4); 3.1441 (2.4); 3.1327 (2.2); 3.1149 (0.9); 3.0926 (0.9); 3.0766 (1.6); 3.0639 (1.7); 2.7819 (0.7); 2.6704 (0.5); 2.5621 (1.2); 2.5509 (1.0); 2.5241 (1.5); 2.5192 (1.8); 2.5105 (30.0); 2.5060 (66.1); 2.5013 (93.4); 2.4967 (65.1); 2.4921 (29.0); 2.4555 (0.5); 2.4509 (0.6); 2.3743 (1.0); 2.3555 (0.9); 2.3327 (1.1); 2.3235 (0.5); 2.3061 (0.8); 2.2925 (0.9); 2.2819 (1.2); 2.2683 (1.2); 2.2621 (1.6); 2.2506 (0.5); 2.2404 (1.8); 2.2263 (1.6); 2.2046 (1.1); 2.1575 (0.6); 2.1450 (0.5); 2.1333 (0.6); 2.1258 (0.8); 2.1016 (0.6); 2.0733 (0.9); 1.7658 (0.5); 1.7552 (0.7); 1.7444 (0.6); 1.7339 (0.6); 1.7234 (0.6); 1.1915 (7.2); 1.1734 (16.0); 1.1552 (6.8); 1.1419 (1.1); - 0.0002 (2.7) I.1-377: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4891 (0.8); 8.4748 (1.6); 8.4603 (0.8); 7.3658 (0.8); 7.3489 (1.0); 7.3441 (1.7); 7.3274 (1.8); 7.3224 (1.0); 7.3056 (1.0); 7.2441 (1.2); 7.2377 (1.2); 7.2206 (1.3); 7.2179 (1.4); 7.2142 (1.4); 7.2115 (1.4); 7.1944 (1.2); 7.1880 (1.2); 7.1361 (2.7); 7.1162 (6.6); 7.0911 (7.5); 7.0706 (3.5); 7.0555 (1.6); 7.0529 (1.6); 7.0489 (1.4); 7.0466 (1.4); 7.0342 (0.7); 7.0315 (0.8); 7.0275 (0.6); 7.0251 (0.6); 4.6602 (2.0); 4.6223 (2.2); 4.2452 (3.6); 4.2311 (3.5); 3.9880 (2.3); 3.9498 (2.0); 3.7239 (0.8); 3.7130 (1.0); 3.7021 (1.2); 3.6927 (1.1); 3.6820 (0.9); 3.6710 (0.6); 3.6067 (1.5); 2.5755 (1.3); 2.5645 (1.3); 2.5406 (1.8); 2.5297 (1.8); 2.5251 (1.0); 2.5203 (1.3); 2.5115 (16.6); 2.5069 (36.2); 2.5023 (50.4); 2.4977 (35.2); 2.4932 (15.5); 2.3330 (1.3); 2.3136 (1.1); 2.2909 (1.0); 2.2725 (16.0); 2.2503 (1.2); 2.2400 (1.3); 2.2263 (1.3); 2.2084 (0.6); 2.1950 (1.8); 2.1846 (0.7); 2.1724 (1.7); 2.1600 (1.5); 2.1375 (1.4); 2.0414 (0.8); 2.0369 (0.6); 2.0288 (0.6); 2.0222 (0.5); 2.0173 (0.7); 2.0098 (1.0); 2.0051 (0.6); 1.9901 (0.6); 1.9856 (0.8); 1.7014 (0.6); 1.6909 (0.9); 1.6806 (0.7); 1.6693 (0.7); 1.6588 (0.7); -0.0002 (15.7) I.1-378: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.4685 (1.8); 10.4643 (1.8); 8.0451 (0.8); 8.0308 (1.7); 8.0163 (0.8); 7.1423 (2.3); 7.1221 (7.5); 7.1181 (6.0); 7.1052 (8.3); 7.0965 (4.8); 7.0955 (4.8); 7.0846 (2.4); 7.0112 (3.0); 7.0056 (2.9); 6.8073 (3.5); 6.8015 (3.7); 6.5917 (2.5); 6.5860 (2.3); 6.5702 (2.3); 6.5644 (2.2); 4.6693 (1.9); 4.6312 (2.1); 4.0078 (2.2); 3.9697 (2.0); 3.7244 (0.8); 3.7134 (1.0); 3.7027 (1.2); 3.6932 (1.1); 3.6822 (0.9); 3.6716 (0.6); 3.5741 (2.3); 3.5187 (14.0); 3.3003 (1.0); 3.2831 (1.9); 3.2664 (1.9); 3.2490 (1.2); 3.1681 (1.0); 2.7098 (1.9); 2.6906 (2.9); 2.6732 (1.9); 2.6656 (0.7); 2.5235 (1.4); 2.5187 (2.3); 2.5101 (35.0); 2.5055 (77.3); 2.5009 (107.4); 2.4963 (75.4); 2.4917 (33.8); 2.4810 (2.2); 2.4698 (1.8); 2.3593 (0.5); 2.3555 (0.6); 2.3366 (1.4); 2.3277 (0.8); 2.3230 (0.7); 2.3179 (1.2); 2.2940 (0.9); 2.2748 (16.0); 2.2573 (1.0); 2.2436 (1.1); 2.2332 (1.3); 2.2195 (1.2); 2.2017 (0.6); 2.1914 (0.7); 2.1777 (0.6); 2.1261 (1.5); 2.1035 (1.5); 2.0915 (1.3); 2.0727 (2.7); 2.0690 (1.4); 2.0304 (0.7); 2.0181 (0.6); 2.0112 (0.5); 2.0062 (0.7); 1.9987 (0.9); 1.9941 (0.6); 1.9793 (0.6); 1.9746 (0.7); 1.6903 (0.6); 1.6795 (0.8); 1.6693 (0.7); 1.6579 (0.7); 1.6475 (0.7); -0.0002 (6.8) I.1-379: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9122 (1.5); 8.8909 (1.6); 7.3450 (1.7); 7.3402 (2.2); 7.3259 (4.0); 7.3236 (4.0); 7.3215 (4.1); 7.3190 (3.5); 7.3082 (3.9); 7.3034 (4.5); 7.2594 (2.5); 7.2498 (8.5); 7.2428 (3.7); 7.2340 (5.6); 7.2297 (4.8); 7.2213 (1.0); 7.2173 (0.8); 7.1693 (0.5); 7.1637 (1.7); 7.1593 (1.8); 7.1546 (5.9); 7.1512 (6.9); 7.1436 (1.2); 7.1346 (1.6); 7.1244 (1.3); 7.1121 (0.6); 7.0914 (1.8); 7.0760 (1.1); 6.1043 (1.9); 6.0830 (1.8); 4.6928 (1.7); 4.6534 (1.9); 4.0259 (1.8); 3.9866 (1.6); 3.7134 (0.7); 3.7027 (0.9); 3.6918 (0.7); 3.3537 (33.4); 2.6742 (0.7); 2.6696 (1.0); 2.6650 (0.7); 2.6446 (1.0); 2.6339 (1.0); 2.6097 (1.3); 2.5993 (1.4); 2.5230 (3.0); 2.5183 (4.4); 2.5097 (56.2); 2.5051 (120.0); 2.5005 (166.7); 2.4959 (116.6); 2.4914 (51.9); 2.4550 (0.8); 2.4506 (0.8); 2.4459 (0.6); 2.3876 (0.7); 2.3733 (1.4); 2.3677 (1.0); 2.3507 (1.6); 2.3456 (1.5); 2.3386 (1.4); 2.3319 (1.0); 2.3272 (1.4); 2.3227 (1.5); 2.3164 (1.2); 2.2879 (0.7); 2.2765 (0.8); 2.2637 (1.1); 2.2524 (1.0); 2.2217 (0.6); 2.2106 (0.5); 2.1829 (16.0); 2.0852 (0.6); 2.0733 (0.6); 2.0618 (0.6); 2.0531 (0.8); 2.0301 (0.6); 1.7790 (0.5); 1.7575 (0.7); 1.7466 (0.7); 0.0080 (1.0); -0.0002 (33.6); - 0.0085 (0.9) I.1-380: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1541 (4.6); 7.1412 (2.7); 3.4508 (16.0); 3.2086 (1.9); 3.1672 (5.4); 2.7569 (2.0); 2.6697 (4.4); 2.5866 (3.4); 2.5673 (4.5); 2.5392 (6.3); 2.5347 (7.1); 2.5298 (6.3); 2.5231 (13.3); 2.5183 (20.0); 2.5097 (267.7); 2.5052 (569.6); 2.5006 (783.0); 2.4960 (547.4); 2.4915 (245.6); 2.3273 (4.9); 2.0732 (1.5); 1.1827 (3.0); 1.1637 (6.2); 1.1445 (3.7); 0.8481 (4.4); 0.8305 (5.7); 0.0080 (6.9); -0.0002 (264.6); -0.0085 (9.0); -0.1496 (1.3) I.1-381: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2396 (0.5); 8.2262 (1.0); 8.2127 (0.5); 7.5640 (4.2); 7.2896 (4.4); 7.2881 (4.4); 7.1391 (1.8); 7.1191 (5.1); 7.0984 (5.7); 7.0779 (1.8); 4.6597 (1.4); 4.6216 (1.6); 4.0839 (1.9); 4.0656 (9.2); 4.0509 (4.1); 4.0476 (7.0); 4.0294 (2.0); 3.9861 (1.7); 3.9481 (1.6); 3.7882 (1.2); 3.7384 (0.6); 3.7276 (0.8); 3.7167 (1.0); 3.7061 (1.0); 3.6964 (0.9); 3.6856 (0.7); 2.5167 (1.4); 2.5102 (7.3); 2.5056 (16.4); 2.5010 (21.7); 2.4963 (15.0); 2.4918 (6.6); 2.4823 (1.3); 2.4712 (1.2); 2.3326 (0.9); 2.3134 (0.8); 2.2901 (0.8); 2.2742 (11.9); 2.2596 (0.8); 2.2460 (0.9); 2.2355 (1.0); 2.2220 (1.0); 2.1936 (0.5); 2.1468 (1.3); 2.1244 (1.3); 2.1122 (1.2); 2.0898 (1.1); 2.0457 (0.6); 2.0215 (0.6); 2.0140 (0.7); 1.9898 (0.6); 1.6967 (0.7); 1.6865 (0.5); 1.6751 (0.5); 1.6647 (0.6); 1.3340 (7.2); 1.3158 (16.0); 1.2976 (7.1); -0.0002 (1.8) I.1-382: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2616 (0.6); 8.2474 (1.2); 8.2336 (0.6); 7.1503 (2.1); 7.1303 (6.0); 7.1100 (6.9); 7.0895 (2.2); 4.6680 (1.7); 4.6297 (1.8); 4.0313 (1.9); 3.9930 (1.7); 3.7401 (0.6); 3.7291 (0.8); 3.7180 (0.9); 3.7087 (0.8); 3.6979 (0.6); 3.3842 (0.8); 3.3680 (2.1); 3.3520 (2.6); 3.3290 (44.3); 3.1851 (0.6); 3.1560 (2.0); 3.1460 (2.4); 3.1287 (2.2); 3.0714 (1.5); 3.0592 (1.5); 3.0436 (0.7); 2.5498 (1.2); 2.5391 (1.2); 2.5236 (1.0); 2.5188 (1.6); 2.5102 (22.6); 2.5056 (49.4); 2.5010 (69.1); 2.4964 (48.3); 2.4918 (21.5); 2.3607 (1.0); 2.3419 (0.9); 2.3374 (1.0); 2.3278 (0.6); 2.3187 (0.9); 2.2909 (1.0); 2.2784 (14.4); 2.2670 (1.4); 2.2530 (1.2); 2.2250 (0.6); 2.2112 (0.6); 2.1780 (1.4); 2.1554 (1.4); 2.1425 (1.2); 2.1198 (1.3); 2.0835 (0.6); 2.0710 (0.5); 2.0594 (0.6); 2.0521 (0.8); 2.0470 (0.5); 2.0278 (0.6); 1.7189 (0.5); 1.7081 (0.7); 1.6976 (0.6); 1.6866 (0.6); 1.6759 (0.6); 1.1869 (7.2); 1.1688 (16.0); 1.1506 (6.9); -0.0002 (13.6); -0.0028 (0.7) I.1-383: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1745 (0.5); 7.2333 (1.6); 7.2152 (2.9); 7.1961 (1.7); 7.0881 (2.0); 7.0687 (1.5); 7.0136 (4.3); 6.9921 (1.4); 4.6549 (1.7); 4.6166 (2.0); 4.0776 (1.9); 4.0386 (2.0); 3.8293 (1.8); 3.6033 (7.0); 3.5848 (6.8); 3.2132 (2.1); 3.1870 (1.3); 3.1672 (9.0); 3.1520 (2.6); 3.1376 (2.2); 3.1210 (1.1); 3.1089 (1.2); 3.0373 (1.1); 3.0254 (2.6); 2.9999 (2.2); 2.9588 (1.2); 2.9504 (1.1); 2.7659 (14.8); 2.7535 (14.4); 2.6790 (1.8); 2.6743 (3.7); 2.6697 (5.3); 2.6651 (3.9); 2.6435 (0.9); 2.5371 (2.6); 2.5321 (5.6); 2.5232 (17.4); 2.5185 (23.4); 2.5098 (273.0); 2.5053 (582.8); 2.5007 (807.5); 2.4961 (563.2); 2.4915 (248.7); 2.4662 (2.2); 2.4554 (4.0); 2.4506 (4.1); 2.4141 (1.6); 2.3948 (1.8); 2.3723 (0.8); 2.3321 (3.8); 2.3274 (5.2); 2.3228 (3.9); 2.3182 (2.1); 2.2931 (7.0); 2.2836 (16.0); 2.2479 (1.1); 2.1765 (1.0); 2.1440 (1.0); 2.1229 (0.8); 2.0732 (2.4); 1.7974 (1.2); 1.7764 (1.4); 1.7388 (0.8); 1.6943 (0.9); 1.6840 (0.8); 1.1853 (1.1); 1.0708 (5.6); 1.0528 (12.5); 1.0348 (5.4); 0.1460 (1.2); 0.0324 (0.9); 0.0080 (10.0); -0.0002 (334.8); -0.0085 (9.6); -0.0344 (1.1); -0.0504 (1.0); -0.1496 (1.2) I.1-384: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0053 (1.0); 7.9959 (1.0); 7.1758 (1.9); 7.1677 (8.0); 7.1629 (4.1); 7.1585 (1.2); 7.1513 (1.6); 7.1455 (0.6); 7.1387 (1.0); 7.0821 (1.4); 7.0699 (1.3); 7.0628 (0.6); 4.6886 (1.7); 4.6490 (1.9); 4.0323 (1.7); 3.9928 (1.6); 3.6967 (0.7); 3.6858 (0.9); 3.6751 (0.8); 3.3258 (7.9); 3.1848 (1.0); 3.1156 (0.5); 3.1039 (0.5); 3.0972 (0.5); 3.0859 (0.5); 2.5914 (0.6); 2.5817 (0.8); 2.5732 (1.2); 2.5634 (1.3); 2.5551 (0.8); 2.5453 (0.6); 2.5232 (0.5); 2.5185 (0.8); 2.5098 (12.2); 2.5053 (26.6); 2.5007 (36.9); 2.4961 (25.8); 2.4915 (11.6); 2.4418 (1.2); 2.4308 (1.1); 2.4070 (1.6); 2.3960 (1.3); 2.3860 (0.7); 2.3652 (0.8); 2.3442 (1.2); 2.3225 (0.8); 2.2955 (0.8); 2.2839 (1.0); 2.2714 (1.1); 2.2599 (1.0); 2.2420 (0.8); 2.2287 (16.0); 2.2184 (0.7); 2.1225 (1.5); 2.1079 (0.7); 2.1000 (1.6); 2.0876 (1.6); 2.0760 (0.8); 2.0731 (0.8); 2.0652 (1.3); 2.0526 (0.6); 1.7136 (0.8); 1.7024 (0.7); 1.1934 (1.7); 1.1752 (3.7); 1.1570 (1.7); 0.6043 (0.9); 0.5923 (2.2); 0.5870 (2.9); 0.5748 (2.8); 0.5692 (2.4); 0.5574 (1.0); 0.3484 (1.1); 0.3372 (2.6); 0.3319 (2.4); 0.3271 (2.3); 0.3220 (2.4); 0.3101 (0.9); -0.0002 (15.4) I.1-385: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2614 (11.3); 7.1099 (8.7); 6.3376 (0.9); 6.3320 (0.7); 6.3061 (2.2); 6.3005 (1.6); 4.7115 (0.6); 4.6740 (0.6); 4.1104 (0.6); 4.0729 (0.5); 3.7717 (16.0); 2.7192 (0.6); 2.7020 (1.2); 2.6848 (0.5); 2.4502 (0.7); 2.3200 (4.9); -0.0002 (3.1) I.1-387: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2276 (2.3); 7.2237 (2.7); 7.2141 (6.4); 7.2105 (5.7); 7.2048 (2.1); 7.1784 (1.2); 7.1714 (0.8); 7.1647 (1.8); 7.1580 (2.3); 7.1516 (1.8); 7.1447 (2.0); 7.1386 (3.0); 7.1185 (1.4); 7.0991 (0.5); 7.0770 (0.7); 5.0488 (1.4); 5.0345 (1.4); 4.8145 (1.3); 4.7999 (0.8); 4.7748 (2.5); 4.7663 (1.0); 4.7353 (1.8); 4.2880 (0.6); 4.2547 (0.6); 4.1695 (1.0); 4.1517 (1.3); 4.1358 (2.1); 4.1150 (3.0); 4.1057 (2.9); 4.1024 (3.0); 4.0972 (3.3); 4.0896 (4.3); 4.0848 (2.8); 4.0790 (1.8); 4.0720 (4.4); 4.0544 (1.2); 4.0447 (0.7); 4.0304 (0.7); 4.0062 (0.6); 3.7082 (1.2); 3.6845 (1.3); 3.3773 (33.3); 3.1659 (0.7); 3.0069 (0.6); 2.9840 (0.5); 2.9607 (0.6); 2.8572 (0.8); 2.8170 (0.9); 2.7905 (0.5); 2.7809 (0.6); 2.7504 (0.7); 2.7414 (0.6); 2.6697 (1.2); 2.6652 (0.8); 2.6183 (1.4); 2.5994 (4.4); 2.5933 (2.2); 2.5808 (4.6); 2.5749 (3.0); 2.5624 (1.9); 2.5560 (2.7); 2.5469 (1.0); 2.5400 (1.2); 2.5232 (3.4); 2.5186 (4.2); 2.5099 (66.9); 2.5053 (147.4); 2.5007 (206.9); 2.4961 (145.1); 2.4914 (64.4); 2.4596 (1.7); 2.4356 (1.9); 2.4122 (1.3); 2.3964 (1.2); 2.3738 (0.7); 2.3529 (0.7); 2.3321 (1.1); 2.3275 (1.2); 2.3227 (1.0); 2.2787 (1.0); 2.2688 (1.0); 2.2627 (0.8); 2.2546 (1.4); 2.2441 (1.2); 2.2375 (1.3); 2.2129 (0.7); 2.2028 (0.9); 2.1959 (0.7); 2.1459 (0.6); 2.1272 (1.0); 2.0768 (1.6); 2.0474 (1.1); 1.6844 (0.8); 1.5986 (1.5); 1.2184 (3.2); 1.2006 (6.0); 1.1880 (6.4); 1.1828 (4.0); 1.1807 (3.8); 1.1702 (16.0); 1.1628 (6.0); 1.1522 (14.6); 1.1450 (3.5); 1.1388 (6.2); 1.1344 (5.6); 1.1221 (12.1); 1.1201 (12.0); 1.1036 (7.8); 1.0851 (1.8); 0.0119 (0.6); 0.0111 (0.7); 0.0080 (4.9); 0.0063 (1.6); 0.0055 (1.8); 0.0047 (2.2); 0.0039 (2.8); 0.0022 (7.2); -0.0002 (154.3); -0.0027 (8.7); -0.0051 (2.0); -0.0060 (1.5); -0.0068 (1.3); -0.0085 (4.3) I.1-388: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3036 (1.6); 8.2987 (1.5); 8.2776 (0.7); 8.2726 (0.7); 7.7143 (1.0); 7.7080 (1.0); 7.6938 (1.6); 7.6875 (1.5); 7.6734 (0.5); 7.6672 (0.5); 7.4920 (2.0); 7.4903 (2.2); 7.4714 (1.7); 7.4698 (1.8); 4.6733 (1.0); 4.6342 (1.3); 4.6002 (0.6); 4.2092 (1.2); 4.1941 (2.3); 4.1860 (0.7); 4.1701 (1.0); 4.0410 (6.0); 3.8300 (0.6); 3.8214 (0.8); 3.8119 (0.6); 3.6737 (7.2); 3.6249 (16.0); 3.3996 (70.1); 3.1671 (1.5); 3.0144 (0.7); 2.9640 (14.4); 2.8432 (0.6); 2.8317 (0.6); 2.8026 (0.8); 2.7910 (0.8); 2.7730 (5.0); 2.6747 (1.0); 2.6701 (1.4); 2.6654 (1.0); 2.5605 (0.6); 2.5559 (1.3); 2.5513 (1.7); 2.5465 (1.5); 2.5404 (1.3); 2.5318 (0.6); 2.5235 (4.1); 2.5189 (5.0); 2.5102 (77.1); 2.5056 (169.2); 2.5010 (236.4); 2.4963 (165.7); 2.4917 (73.5); 2.4722 (0.8); 2.4674 (0.9); 2.4626 (0.7); 2.4152 (0.7); 2.3910 (0.6); 2.3819 (0.6); 2.3608 (0.5); 2.3417 (0.6); 2.3324 (1.2); 2.3277 (1.6); 2.3231 (1.2); 2.2525 (0.7); 2.2398 (0.7); 2.2005 (0.6); 2.1929 (0.7); 2.1756 (0.6); 2.1444 (0.6); 1.6346 (0.5); 0.0079 (1.3); 0.0046 (0.5); -0.0002 (49.9); -0.0085 (1.5) I.1-389: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.5994 (14.1); 8.6430 (14.2); 8.6273 (16.0); 8.6165 (2.6); 8.2522 (5.8); 8.2321 (6.6); 8.2187 (6.9); 8.2028 (6.4); 7.8746 (4.3); 7.8593 (7.6); 7.8239 (8.6); 7.8037 (8.4); 7.7858 (4.6); 7.3755 (1.4); 7.3715 (1.5); 7.3550 (3.0); 7.3511 (3.2); 7.3451 (1.8); 7.3351 (2.3); 7.3289 (3.1); 7.3248 (2.7); 7.3087 (1.6); 7.3049 (1.6); 7.1952 (1.9); 7.1913 (2.1); 7.1824 (1.9); 7.1787 (2.4); 7.1753 (3.4); 7.1715 (3.7); 7.1624 (3.2); 7.1591 (3.7); 7.1550 (2.3); 7.1510 (2.1); 7.1421 (1.8); 7.1386 (2.0); 7.0662 (3.4); 7.0501 (4.6); 7.0308 (2.3); 4.8187 (2.0); 4.8043 (2.0); 4.7804 (5.0); 4.7659 (5.0); 4.7402 (5.1); 4.7267 (5.3); 4.7146 (5.6); 4.7024 (2.5); 4.6886 (2.4); 4.6750 (6.3); 4.2669 (2.0); 4.2195 (7.8); 4.1799 (7.0); 3.9648 (1.2); 3.8860 (1.1); 3.8516 (1.7); 3.8410 (2.7); 3.8305 (3.6); 3.8203 (4.2); 3.8101 (3.6); 3.7996 (2.7); 3.7890 (1.5); 3.6215 (0.6); 3.6027 (0.9); 3.5859 (0.8); 3.1666 (6.9); 3.1521 (0.6); 3.1341 (0.5); 3.0336 (0.7); 2.7710 (4.2); 2.7600 (3.2); 2.6799 (0.6); 2.6753 (1.3); 2.6707 (2.0); 2.6660 (1.5); 2.6614 (0.6); 2.6301 (3.8); 2.6192 (4.0); 2.5949 (4.6); 2.5839 (4.7); 2.5242 (3.7); 2.5195 (5.8); 2.5108 (103.8); 2.5062 (230.3); 2.5016 (323.4); 2.4970 (228.1); 2.4924 (102.3); 2.4219 (0.6); 2.4054 (0.8); 2.3713 (1.2); 2.3484 (1.6); 2.3286 (5.4); 2.3239 (2.3); 2.3131 (6.8); 2.2916 (6.0); 2.2782 (4.9); 2.2688 (3.2); 2.2560 (6.9); 2.2448 (4.6); 2.2315 (4.3); 2.2138 (1.4); 2.2029 (2.2); 2.1901 (2.2); 2.1517 (1.6); 2.1323 (2.6); 2.1202 (1.9); 2.1130 (1.7); 2.1085 (2.3); 2.1010 (3.1); 2.0965 (2.0); 2.0893 (1.2); 2.0811 (1.8); 2.0770 (2.3); 2.0739 (1.6); 2.0574 (1.0); 1.8103 (0.5); 1.7771 (1.4); 1.7648 (2.1); 1.7538 (2.8); 1.7434 (2.4); 1.7327 (2.4); 1.7220 (2.6); 1.7114 (1.5); 1.6983 (1.1); 1.0684 (1.7); 1.0504 (4.0); 1.0325 (1.8); 0.1460 (0.6); 0.0080 (6.2); -0.0002 (228.7); -0.0086 (6.4); -0.1494 (0.6) I.1-390: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1681 (3.8); 7.5413 (2.6); 7.4244 (5.1); 7.3955 (8.8); 7.3769 (6.9); 7.3513 (2.8); 7.3337 (2.8); 7.2059 (11.1); 7.2022 (16.0); 7.1848 (10.3); 4.3884 (1.8); 4.3494 (2.7); 4.1620 (2.8); 4.1233 (2.1); 3.8371 (2.3); 3.4475 (3.4); 3.4047 (3.0); 3.3472 (1325.9); 3.2990 (11.7); 3.2298 (1.6); 3.1671 (7.6); 3.1053 (14.8); 2.6746 (7.0); 2.6701 (9.5); 2.6655 (6.6); 2.6060 (2.6); 2.6020 (2.8); 2.5401 (4.6); 2.5234 (27.6); 2.5186 (42.8); 2.5100 (546.6); 2.5055 (1157.8); 2.5009 (1594.9); 2.4963 (1136.1); 2.4918 (519.3); 2.4559 (10.5); 2.4517 (11.0); 2.4117 (3.0); 2.3779 (2.9); 2.3323 (8.0); 2.3277 (10.6); 2.3231 (7.6); 2.2226 (4.1); 2.1741 (2.4); 2.0731 (2.1); 2.0061 (1.8); 1.6126 (1.7); 0.0080 (7.4); -0.0002 (242.4); -0.0085 (8.1); -0.0496 (1.3) I.1-391: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0095 (1.2); 7.9997 (1.2); 7.1738 (2.6); 7.1533 (6.7); 7.1283 (6.4); 7.1078 (2.4); 4.6657 (1.8); 4.6276 (2.0); 3.9973 (2.0); 3.9592 (1.8); 3.7202 (0.6); 3.7093 (0.8); 3.6990 (1.0); 3.6891 (0.8); 3.6782 (0.6); 3.3160 (17.9); 2.7917 (0.6); 2.6698 (0.6); 2.6054 (1.3); 2.6001 (0.9); 2.5866 (4.0); 2.5822 (2.0); 2.5676 (4.1); 2.5481 (1.5); 2.5399 (0.6); 2.5346 (0.5); 2.5298 (0.5); 2.5233 (1.5); 2.5186 (2.2); 2.5099 (33.2); 2.5053 (72.2); 2.5007 (101.1); 2.4961 (71.3); 2.4916 (32.1); 2.4648 (1.4); 2.4534 (1.2); 2.4301 (1.6); 2.4189 (1.5); 2.3326 (1.3); 2.3276 (0.8); 2.3229 (0.6); 2.3143 (1.0); 2.2916 (0.8); 2.2657 (0.8); 2.2520 (1.0); 2.2416 (1.2); 2.2279 (1.2); 2.1997 (0.6); 2.1861 (0.6); 2.0734 (1.9); 2.0561 (0.9); 2.0512 (1.9); 2.0437 (0.7); 2.0385 (1.6); 2.0323 (0.8); 2.0246 (0.9); 2.0164 (1.5); 2.0051 (0.5); 2.0004 (0.7); 1.6865 (0.6); 1.6757 (0.8); 1.6655 (0.7); 1.6540 (0.6); 1.6436 (0.7); 1.1837 (7.1); 1.1751 (0.8); 1.1647 (16.0); 1.1457 (6.8); 0.6097 (1.0); 0.5977 (2.4); 0.5928 (3.1); 0.5808 (2.8); 0.5749 (2.5); 0.5633 (1.1); 0.3582 (1.1); 0.3474 (3.0); 0.3407 (2.7); 0.3374 (2.6); 0.3314 (2.5); 0.3212 (0.8); 0.0080 (1.6); -0.0002 (54.8); - 0.0086 (1.6) I.1-392: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9258 (1.0); 8.9045 (1.0); 7.3517 (0.8); 7.3494 (1.1); 7.3453 (1.1); 7.3432 (1.2); 7.3280 (2.7); 7.3228 (2.1); 7.3126 (2.9); 7.3066 (2.5); 7.2681 (3.8); 7.2571 (4.1); 7.2507 (2.9); 7.2477 (2.5); 7.2390 (2.9); 7.2314 (0.6); 7.2283 (0.6); 7.1779 (2.2); 7.1577 (3.8); 7.0996 (3.4); 7.0792 (2.0); 6.1162 (1.3); 6.0949 (1.2); 4.6735 (1.1); 4.6356 (1.2); 3.9725 (1.2); 3.9344 (1.1); 3.7317 (0.5); 3.7218 (0.6); 3.7117 (0.5); 3.3556 (12.2); 2.8645 (0.7); 2.8472 (0.9); 2.8299 (0.7); 2.6741 (0.5); 2.6693 (1.2); 2.6651 (0.6); 2.6576 (0.7); 2.6341 (0.8); 2.6231 (0.7); 2.5442 (0.7); 2.5395 (0.8); 2.5339 (0.8); 2.5230 (2.1); 2.5183 (3.0); 2.5096 (33.6); 2.5051 (71.0); 2.5004 (98.0); 2.4958 (68.0); 2.4913 (29.7); 2.4447 (0.5); 2.3405 (0.9); 2.3321 (1.0); 2.3273 (0.8); 2.3223 (0.7); 2.3182 (1.2); 2.3060 (0.9); 2.2908 (0.5); 2.2838 (0.7); 2.2471 (0.5); 2.2365 (0.6); 2.2230 (0.6); 1.1837 (16.0); 1.1664 (15.8); 0.0080 (1.0); -0.0002 (30.6); -0.0086 (0.8) I.1-393: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1728 (8.2); 7.1553 (1.7); 7.1468 (1.2); 7.1431 (1.4); 7.1322 (1.8); 7.1182 (0.9); 7.1129 (1.0); 5.0468 (1.0); 5.0371 (1.0); 4.7629 (0.9); 4.7439 (0.6); 4.7235 (1.3); 4.7182 (1.1); 4.7102 (0.7); 4.6789 (1.2); 4.1698 (0.7); 4.1521 (0.9); 4.1359 (0.9); 4.1173 (2.0); 4.1072 (2.2); 4.1037 (1.8); 4.0991 (2.0); 4.0900 (3.8); 4.0861 (1.8); 4.0813 (1.2); 4.0724 (3.2); 4.0548 (1.4); 3.7241 (0.6); 3.7139 (0.6); 3.7040 (0.7); 3.6942 (0.7); 3.6800 (0.7); 3.6687 (0.9); 3.6606 (0.9); 3.4557 (2.5); 3.1678 (0.7); 2.8472 (0.6); 2.8377 (0.5); 2.8074 (0.7); 2.7978 (0.6); 2.7473 (0.6); 2.7386 (0.5); 2.5554 (0.6); 2.5490 (0.9); 2.5326 (0.6); 2.5233 (1.6); 2.5184 (1.9); 2.5098 (22.9); 2.5052 (48.4); 2.5006 (66.7); 2.4960 (46.0); 2.4914 (20.4); 2.4664 (0.8); 2.4606 (1.0); 2.4371 (0.7); 2.4207 (1.1); 2.3977 (0.9); 2.3272 (0.6); 2.2897 (0.5); 2.2787 (1.0); 2.2656 (0.8); 2.2543 (1.1); 2.2480 (0.9); 2.2183 (16.0); 2.2133 (6.1); 2.1989 (3.5); 2.1553 (0.5); 2.1317 (0.8); 2.1226 (0.8); 2.1118 (0.8); 2.1047 (0.8); 2.0807 (1.0); 2.0731 (1.0); 2.0424 (0.7); 1.6828 (0.6); 1.6729 (0.7); 1.6596 (0.7); 1.6499 (1.0); 1.6405 (0.9); 1.6270 (1.0); 1.6169 (1.0); 1.5949 (1.1); 1.5621 (1.0); 1.2197 (2.1); 1.2020 (4.4); 1.1892 (4.0); 1.1842 (3.0); 1.1812 (2.4); 1.1713 (10.2); 1.1633 (3.7); 1.1533 (9.9); 1.1457 (1.8); 1.1354 (3.4); 0.0080 (0.7); -0.0002 (25.0); -0.0085 (0.7) I.1-395: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3570 (0.9); 7.3344 (0.9); 7.1983 (0.6); 7.1903 (0.9); 7.1871 (0.9); 7.1785 (1.0); 7.1704 (0.7); 7.1667 (0.8); 7.1583 (0.5); 7.0993 (0.7); 7.0831 (0.9); 7.0642 (0.7); 4.7584 (1.3); 4.7187 (1.6); 4.2737 (1.3); 4.2341 (1.1); 4.1986 (0.7); 4.1597 (0.6); 4.0877 (2.2); 3.9436 (3.9); 3.9370 (3.8); 3.8362 (0.7); 3.8255 (0.9); 3.8158 (0.8); 3.8049 (0.6); 3.3304 (61.3); 2.9487 (16.0); 2.8403 (0.7); 2.8300 (0.7); 2.7997 (0.9); 2.7895 (1.0); 2.7633 (7.2); 2.6754 (0.6); 2.6708 (0.9); 2.6663 (0.6); 2.5293 (1.7); 2.5243 (3.2); 2.5196 (4.6); 2.5109 (49.9); 2.5064 (105.5); 2.5018 (145.5); 2.4972 (101.6); 2.4927 (44.8); 2.4726 (0.8); 2.4680 (1.1); 2.4634 (1.0); 2.4562 (1.0); 2.4513 (1.1); 2.4469 (0.9); 2.4334 (0.8); 2.4137 (0.7); 2.3999 (0.7); 2.3777 (0.6); 2.3374 (0.8); 2.3333 (0.8); 2.3286 (1.1); 2.3239 (0.8); 2.2660 (0.7); 2.2543 (0.7); 2.2416 (1.2); 2.2302 (1.1); 2.2004 (0.9); 2.1942 (1.4); 2.1795 (0.8); 2.1676 (0.6); 2.1605 (0.5); 2.1487 (0.9); 2.1286 (0.5); 2.1246 (0.6); 1.6732 (0.6); 0.0080 (1.6); -0.0002 (51.1); -0.0086 (1.4) I.1-397: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9285 (0.7); 7.9140 (1.4); 7.8997 (0.7); 7.1445 (2.0); 7.1243 (7.4); 7.1093 (8.2); 7.0886 (2.2); 4.6685 (2.0); 4.6306 (2.2); 4.0119 (2.2); 3.9740 (2.0); 3.7161 (0.5); 3.7052 (0.9); 3.6943 (1.2); 3.6832 (1.5); 3.6743 (1.5); 3.6631 (1.5); 3.6528 (1.3); 2.8885 (1.3); 2.8713 (2.6); 2.8562 (2.7); 2.8396 (1.3); 2.5247 (0.7); 2.5200 (1.0); 2.5112 (16.1); 2.5067 (33.0); 2.5021 (46.4); 2.4975 (32.6); 2.4929 (14.4); 2.4768 (1.8); 2.4659 (1.6); 2.3430 (1.1); 2.3242 (1.1); 2.3200 (1.0); 2.3007 (0.9); 2.2755 (16.0); 2.2561 (1.2); 2.2459 (1.3); 2.2320 (1.2); 2.2143 (0.6); 2.2041 (0.6); 2.1902 (0.6); 2.1319 (1.6); 2.1093 (1.6); 2.0976 (1.4); 2.0750 (1.4); 2.0393 (0.7); 2.0348 (0.5); 2.0267 (0.6); 2.0201 (0.5); 2.0151 (0.7); 2.0078 (0.9); 2.0028 (0.6); 1.9883 (0.6); 1.9835 (0.7); 1.7026 (0.6); 1.6917 (0.9); 1.6812 (1.0); 1.6672 (1.5); 1.6595 (1.8); 1.6359 (3.6); 1.6057 (2.3); 1.3373 (0.6); 1.3285 (0.7); 1.3200 (0.6); 1.1666 (0.8); 1.1339 (1.9); 1.1093 (1.4); 0.8712 (0.6); 0.8434 (1.3); 0.8193 (1.1); -0.0002 (9.0) I.1-398: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3034 (1.9); 8.2982 (2.0); 8.2906 (2.1); 8.2856 (2.0); 8.2727 (1.4); 8.2644 (0.9); 7.7136 (1.2); 7.7084 (2.0); 7.7026 (1.4); 7.6929 (1.9); 7.6882 (2.8); 7.6821 (1.8); 7.6752 (0.9); 7.6692 (1.3); 7.6634 (0.7); 7.4907 (5.5); 7.4836 (1.3); 7.4702 (4.6); 7.4631 (1.0); 5.0695 (0.8); 5.0600 (0.9); 5.0437 (0.9); 5.0333 (0.9); 4.6988 (1.3); 4.6603 (2.0); 4.6456 (0.6); 4.6252 (1.8); 4.6064 (0.7); 4.5869 (1.6); 4.2755 (1.9); 4.2365 (1.3); 4.2126 (2.6); 4.1731 (2.5); 4.1639 (1.5); 4.1463 (2.3); 4.1388 (1.2); 4.1291 (3.4); 4.1208 (1.6); 4.1130 (5.7); 4.1023 (1.2); 4.0953 (5.5); 4.0933 (4.3); 4.0846 (0.7); 4.0775 (1.8); 4.0754 (1.5); 3.8875 (1.2); 3.8760 (1.6); 3.8676 (2.0); 3.8562 (2.7); 3.8430 (3.1); 3.8324 (3.7); 3.8221 (4.7); 3.8020 (6.4); 3.7913 (6.9); 3.6761 (1.2); 3.1688 (0.8); 3.0576 (0.6); 3.0502 (0.8); 3.0257 (1.2); 3.0182 (1.3); 2.9932 (0.8); 2.9859 (0.7); 2.8683 (0.9); 2.8558 (0.8); 2.8418 (0.5); 2.8273 (1.3); 2.8143 (1.3); 2.7843 (1.0); 2.7732 (0.9); 2.5838 (1.0); 2.5701 (0.6); 2.5632 (1.1); 2.5504 (1.0); 2.5437 (1.0); 2.5413 (1.1); 2.5243 (1.4); 2.5199 (1.6); 2.5112 (23.8); 2.5066 (52.1); 2.5019 (72.8); 2.4973 (51.2); 2.4927 (22.9); 2.4736 (1.2); 2.4643 (0.5); 2.4531 (1.2); 2.4473 (1.0); 2.4329 (1.3); 2.4231 (1.5); 2.4131 (1.4); 2.4061 (1.5); 2.3995 (1.3); 2.3830 (1.4); 2.3659 (0.9); 2.3517 (0.6); 2.3335 (0.8); 2.3288 (0.8); 2.3167 (0.6); 2.2959 (0.5); 2.2820 (1.0); 2.2693 (1.1); 2.2576 (1.7); 2.2447 (1.7); 2.2163 (1.2); 2.2059 (1.6); 2.1892 (0.9); 2.1790 (0.8); 2.1699 (1.1); 2.1580 (1.1); 2.1485 (1.3); 2.1391 (1.2); 2.1269 (0.6); 2.1146 (1.0); 2.0953 (1.1); 2.0738 (0.7); 2.0565 (1.0); 1.6859 (0.7); 1.6754 (0.8); 1.6678 (1.0); 1.6545 (1.4); 1.6405 (2.0); 1.6334 (1.8); 1.6225 (2.2); 1.6150 (2.2); 1.6013 (2.2); 1.5818 (1.7); 1.5682 (1.4); 1.5430 (0.9); 1.5338 (0.8); 1.5283 (0.9); 1.5191 (0.8); 1.5098 (0.9); 1.4999 (0.8); 1.4949 (0.8); 1.4857 (0.6); 1.3657 (0.5); 1.2485 (0.7); 1.2376 (1.0); 1.2115 (4.4); 1.1938 (12.6); 1.1880 (4.3); 1.1843 (7.2); 1.1760 (16.0); 1.1702 (6.2); 1.1665 (12.9); 1.1583 (6.0); 1.1525 (3.1); 1.1488 (5.7); -0.0002 (3.8) I.1-399: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9127 (2.5); 8.8915 (2.5); 7.3674 (0.7); 7.3631 (0.7); 7.3467 (2.9); 7.3441 (4.4); 7.3407 (4.8); 7.3369 (2.2); 7.3281 (5.6); 7.3253 (7.7); 7.3223 (9.0); 7.3197 (7.9); 7.3076 (6.5); 7.3061 (6.5); 7.3040 (7.8); 7.2602 (3.9); 7.2530 (16.0); 7.2446 (5.8); 7.2358 (9.1); 7.2342 (9.0); 7.2326 (8.8); 7.2306 (7.7); 7.2179 (1.2); 7.2146 (0.5); 7.1875 (0.7); 7.1838 (0.8); 7.1749 (0.8); 7.1710 (1.0); 7.1677 (1.4); 7.1641 (1.5); 7.1547 (1.4); 7.1516 (1.6); 7.1474 (0.9); 7.1434 (0.9); 7.1345 (0.8); 7.1312 (0.8); 7.0651 (1.4); 7.0491 (2.0); 7.0298 (1.0); 6.1058 (3.1); 6.0846 (3.1); 4.7250 (2.2); 4.6854 (2.5); 4.2205 (2.7); 4.1809 (2.3); 3.8221 (0.9); 3.8116 (1.3); 3.8012 (1.5); 3.7913 (1.3); 3.7807 (0.9); 3.3166 (219.2); 3.2928 (12.2); 3.2839 (0.6); 3.2654 (0.5); 2.6706 (2.3); 2.6651 (1.1); 2.6603 (2.1); 2.6364 (2.2); 2.6253 (2.0); 2.5492 (0.5); 2.5447 (0.8); 2.5400 (1.3); 2.5351 (0.9); 2.5304 (0.9); 2.5232 (2.7); 2.5185 (4.0); 2.5098 (54.1); 2.5052 (116.7); 2.5006 (162.6); 2.4960 (113.6); 2.4914 (50.3); 2.3839 (2.4); 2.3621 (2.8); 2.3492 (2.0); 2.3387 (1.7); 2.3320 (1.2); 2.3274 (2.9); 2.3187 (1.8); 2.2966 (1.2); 2.2676 (1.1); 2.2545 (1.4); 2.2436 (1.7); 2.2306 (1.7); 2.2127 (0.6); 2.2017 (0.9); 2.1888 (0.8); 2.1244 (0.6); 2.1047 (1.0); 2.0927 (0.8); 2.0809 (1.0); 2.0730 (1.6); 2.0613 (0.5); 2.0535 (0.8); 2.0492 (1.0); 1.7908 (0.6); 1.7783 (0.8); 1.7676 (1.1); 1.7577 (1.0); 1.7461 (1.0); 1.7358 (1.0); 1.7247 (0.6); 0.0080 (0.6); -0.0002 (18.5); -0.0086 (0.5) I.1-400: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8779 (0.6); 7.1436 (1.1); 7.1234 (4.0); 7.1083 (4.5); 7.1028 (0.9); 7.0876 (1.2); 4.6651 (1.1); 4.6271 (1.2); 4.0106 (1.2); 3.9727 (1.1); 3.7011 (0.5); 3.6903 (0.6); 3.6810 (0.5); 3.4361 (2.0); 3.0460 (0.5); 3.0423 (0.9); 3.0374 (0.6); 3.0329 (1.0); 3.0283 (0.9); 3.0234 (0.7); 3.0192 (0.9); 2.5103 (4.5); 2.5057 (10.0); 2.5011 (14.0); 2.4964 (9.9); 2.4918 (4.6); 2.4778 (0.8); 2.4545 (0.9); 2.4434 (0.8); 2.3402 (0.6); 2.3212 (0.6); 2.3176 (0.5); 2.2758 (8.8); 2.2676 (0.9); 2.2533 (0.7); 2.2431 (0.8); 2.2292 (0.8); 2.1060 (1.0); 2.0835 (1.0); 2.0717 (0.9); 2.0491 (0.9); 2.0092 (0.5); 1.5568 (0.6); 1.5400 (0.9); 1.5232 (0.8); 1.2811 (1.1); 1.2632 (2.8); 1.2456 (2.7); 1.2276 (0.9); 0.8548 (16.0); 0.8382 (15.4); -0.0002 (1.5) I.1-401: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0162 (0.7); 8.0064 (0.7); 7.2049 (2.1); 7.1847 (3.9); 7.1340 (3.4); 7.1136 (1.9); 4.6736 (1.2); 4.6354 (1.3); 3.9877 (1.2); 3.9495 (1.1); 3.7164 (0.5); 3.7062 (0.6); 3.6962 (0.5); 2.8773 (0.7); 2.8601 (1.0); 2.8428 (0.7); 2.5918 (0.5); 2.5833 (0.8); 2.5734 (0.8); 2.5650 (0.5); 2.5190 (0.6); 2.5103 (6.8); 2.5058 (14.6); 2.5011 (20.2); 2.4965 (14.1); 2.4920 (6.2); 2.4769 (0.8); 2.4656 (0.8); 2.4422 (0.9); 2.4309 (0.8); 2.3346 (0.6); 2.3154 (0.6); 2.2537 (0.6); 2.2433 (0.7); 2.2297 (0.7); 2.0858 (1.0); 2.0634 (1.3); 2.0509 (1.1); 2.0290 (1.1); 1.1950 (16.0); 1.1884 (1.2); 1.1777 (15.7); 1.1715 (0.9); 0.6106 (0.6); 0.5986 (1.4); 0.5937 (1.8); 0.5818 (1.7); 0.5758 (1.6); 0.5644 (0.7); 0.3592 (0.7); 0.3483 (1.9); 0.3416 (1.6); 0.3382 (1.6); 0.3323 (1.5); -0.0002 (8.8) I.1-402: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1670 (1.2); 8.1634 (0.6); 8.1528 (0.6); 8.1492 (1.2); 7.2025 (0.9); 7.1871 (0.5); 7.1823 (1.9); 7.1423 (1.7); 7.1219 (0.9); 6.8012 (1.2); 6.7974 (0.7); 6.7873 (0.7); 6.7833 (1.2); 4.6736 (0.6); 4.6352 (0.6); 4.0119 (0.6); 3.9737 (0.6); 3.0703 (16.0); 3.0668 (2.2); 3.0483 (1.3); 2.9434 (7.3); 2.6120 (0.9); 2.5107 (4.0); 2.5061 (8.9); 2.5015 (12.5); 2.4969 (8.9); 2.4924 (4.1); 1.1952 (7.7); 1.1779 (8.8); 1.1593 (2.9); 1.1411 (1.3); -0.0002 (4.7) I.1-409: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1537 (0.6); 8.1400 (1.1); 8.1257 (0.6); 7.1495 (1.6); 7.1293 (5.4); 7.1138 (6.0); 7.0931 (1.6); 4.6803 (1.4); 4.6422 (1.5); 4.0201 (1.6); 3.9819 (1.4); 3.7152 (0.7); 3.7047 (0.8); 3.6947 (0.7); 3.6839 (0.5); 3.3370 (20.0); 3.1848 (0.5); 3.1414 (0.8); 3.1242 (1.7); 3.1095 (3.1); 3.0991 (2.9); 3.0925 (2.8); 3.0816 (3.1); 3.0642 (1.4); 3.0479 (0.6); 3.0200 (0.6); 3.0081 (0.9); 2.9934 (1.0); 2.9809 (0.9); 2.9696 (0.6); 2.7766 (1.1); 2.5211 (1.2); 2.5107 (11.3); 2.5062 (23.1); 2.5015 (32.3); 2.4969 (22.5); 2.4923 (10.1); 2.4868 (1.6); 2.4757 (1.2); 2.3541 (0.8); 2.3315 (0.8); 2.3118 (0.6); 2.2780 (11.7); 2.2699 (1.3); 2.2593 (1.0); 2.2453 (0.9); 2.1569 (1.2); 2.1344 (1.2); 2.1220 (1.0); 2.0994 (1.0); 2.0732 (1.2); 2.0679 (0.5); 2.0437 (0.5); 2.0364 (0.6); 2.0120 (0.5); 1.7371 (1.0); 1.7270 (1.1); 1.7167 (1.5); 1.7093 (1.3); 1.6956 (1.3); 1.6847 (0.7); 1.2137 (0.8); 1.1956 (1.8); 1.1825 (7.1); 1.1644 (16.0); 1.1462 (6.7); 1.1251 (1.2); - 0.0002 (2.0) I.1-414: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.0195 (1.8); 9.0157 (2.0); 9.0085 (2.0); 9.0047 (1.9); 8.6720 (1.2); 8.6498 (1.2); 8.5925 (0.7); 8.5779 (1.4); 8.5632 (0.7); 8.0121 (2.0); 7.9909 (2.5); 7.8176 (1.8); 7.7999 (2.2); 7.7966 (1.7); 7.7786 (1.7); 7.6990 (1.4); 7.6881 (1.4); 7.6777 (1.4); 7.6667 (1.2); 7.5966 (2.1); 7.5790 (1.8); 7.1255 (2.7); 7.1056 (6.7); 7.0832 (7.5); 7.0628 (2.6); 6.8939 (0.6); 4.8201 (0.6); 4.8057 (0.6); 4.7825 (1.5); 4.7683 (1.5); 4.7432 (1.5); 4.7294 (1.6); 4.7049 (0.6); 4.6923 (0.6); 4.6448 (1.9); 4.6069 (2.2); 3.9873 (2.6); 3.9490 (2.5); 3.7521 (4.9); 3.7414 (5.0); 3.7301 (4.9); 3.7209 (4.5); 3.7099 (3.8); 3.1660 (3.8); 2.7560 (0.5); 2.6747 (1.0); 2.6701 (1.4); 2.6654 (1.1); 2.6002 (1.3); 2.5893 (1.1); 2.5655 (1.7); 2.5548 (1.9); 2.5403 (0.9); 2.5235 (3.8); 2.5188 (5.4); 2.5102 (77.3); 2.5056 (168.9); 2.5010 (235.3); 2.4963 (164.7); 2.4917 (72.6); 2.3372 (0.9); 2.3324 (1.2); 2.3278 (1.6); 2.3229 (1.5); 2.3188 (1.6); 2.3004 (1.4); 2.2692 (16.0); 2.2552 (1.5); 2.2414 (1.3); 2.2311 (1.6); 2.2217 (2.0); 2.2175 (1.7); 2.1994 (2.1); 2.1872 (1.7); 2.1754 (0.7); 2.1644 (1.5); 2.1582 (0.7); 2.0732 (1.0); 2.0500 (0.8); 2.0377 (0.6); 2.0260 (0.8); 2.0186 (0.9); 1.9942 (0.7); 1.7034 (0.6); 1.6928 (0.9); 1.6825 (0.7); 1.6711 (0.7); 1.6610 (0.7); 0.0118 (0.6); 0.0110 (0.6); 0.0102 (0.7); 0.0079 (4.4); 0.0063 (1.5); 0.0055 (1.7); 0.0047 (2.0); 0.0038 (2.6); 0.0029 (4.1); 0.0022 (6.6); -0.0002 (144.5); -0.0027 (7.7); -0.0043 (2.8); -0.0052 (1.8); -0.0060 (1.3); -0.0068 (1.2); - 0.0085 (4.1); -0.0099 (0.8); -0.0108 (0.6); -0.0116 (0.5) I.1-415: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3132 (1.5); 8.3054 (1.8); 8.2939 (12.5); 8.2890 (12.9); 8.2876 (12.2); 7.9887 (4.1); 7.9787 (4.1); 7.7399 (0.8); 7.7336 (0.8); 7.7192 (1.7); 7.7130 (1.8); 7.7071 (8.0); 7.7007 (8.0); 7.6865 (9.4); 7.6802 (9.4); 7.4954 (16.0); 7.4940 (16.0); 7.4749 (13.2); 7.4734 (13.3); 5.5653 (0.6); 5.5614 (0.6); 4.8408 (0.6); 4.8245 (0.7); 4.8085 (0.6); 4.7904 (0.6); 4.6152 (9.4); 4.5761 (11.2); 4.4426 (2.0); 4.3359 (1.7); 4.3217 (1.7); 4.3118 (2.3); 4.2973 (2.2); 4.2688 (1.7); 4.1918 (10.2); 4.1526 (8.5); 3.8136 (1.4); 3.8014 (3.1); 3.7932 (3.1); 3.7813 (5.4); 3.7699 (3.2); 3.7613 (3.1); 3.7495 (1.6); 3.1671 (0.6); 2.8937 (0.5); 2.7866 (0.7); 2.7745 (0.8); 2.6758 (1.0); 2.6711 (1.3); 2.6663 (0.9); 2.6053 (1.1); 2.5951 (2.6); 2.5853 (3.6); 2.5769 (5.8); 2.5671 (6.8); 2.5573 (4.5); 2.5492 (3.7); 2.5413 (2.2); 2.5245 (2.8); 2.5199 (4.8); 2.5112 (71.5); 2.5065 (158.5); 2.5019 (222.1); 2.4973 (156.0); 2.4927 (69.1); 2.4772 (1.8); 2.4682 (6.3); 2.4558 (6.9); 2.4328 (7.4); 2.4205 (7.0); 2.3813 (1.6); 2.3642 (2.1); 2.3576 (1.9); 2.3393 (5.0); 2.3335 (2.0); 2.3288 (2.4); 2.3217 (4.6); 2.3162 (4.2); 2.2980 (4.2); 2.2843 (4.3); 2.2694 (5.0); 2.2603 (6.1); 2.2456 (5.7); 2.2276 (1.8); 2.2184 (2.9); 2.2039 (2.7); 2.1366 (2.4); 2.1177 (3.1); 2.1129 (2.2); 2.1018 (8.4); 2.0937 (3.1); 2.0863 (4.0); 2.0810 (9.7); 2.0665 (8.0); 2.0455 (6.8); 1.7135 (1.8); 1.6991 (2.5); 1.6875 (2.7); 1.6780 (2.7); 1.6670 (2.7); 1.6638 (2.3); 1.6554 (2.3); 1.6463 (1.9); 1.6316 (1.4); 0.6109 (4.2); 0.5987 (10.8); 0.5938 (14.5); 0.5816 (13.6); 0.5759 (12.3); 0.5641 (5.3); 0.5420 (0.6); 0.3911 (0.7); 0.3812 (0.7); 0.3657 (0.9); 0.3507 (5.4); 0.3394 (12.6); 0.3336 (10.8); 0.3294 (11.0); 0.3240 (10.9); 0.3130 (3.9); 0.0081 (3.1); -0.0002 (102.8); -0.0086 (2.7) I.1-417: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2528 (0.5); 7.2263 (0.6); 7.2246 (0.6); 7.2081 (1.4); 7.1964 (0.5); 7.1901 (0.6); 7.1617 (0.7); 7.1415 (1.3); 7.1024 (0.7); 7.0869 (0.7); 7.0822 (0.5); 3.6001 (6.1); 3.1336 (1.1); 3.1216 (1.2); 3.1154 (3.7); 3.1034 (3.7); 3.0971 (3.7); 3.0851 (3.7); 3.0790 (1.2); 3.0670 (1.3); 2.5820 (0.5); 2.5626 (0.6); 2.5187 (0.8); 2.5100 (11.1); 2.5055 (24.3); 2.5008 (33.8); 2.4962 (23.8); 2.4916 (10.7); 1.1944 (7.2); 1.1762 (16.0); 1.1579 (9.1); 1.1415 (1.0); 1.1389 (1.0); -0.0002 (16.2) I.1-419: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2217 (2.2); 7.2088 (5.8); 7.1790 (0.8); 7.1718 (1.2); 7.1603 (1.5); 7.1523 (2.0); 7.1391 (1.5); 7.1303 (2.0); 7.1087 (0.8); 7.0884 (1.0); 7.0699 (0.6); 4.7986 (0.8); 4.7828 (1.4); 4.7599 (1.1); 4.7438 (1.6); 4.1180 (1.5); 4.0721 (3.3); 4.0547 (0.9); 4.0161 (1.0); 3.9762 (1.3); 3.9328 (3.6); 3.9195 (3.6); 3.8761 (0.5); 3.7184 (0.9); 3.5901 (0.9); 3.4810 (7.5); 3.1676 (1.4); 2.9247 (16.0); 2.8786 (1.2); 2.8372 (0.5); 2.7910 (0.9); 2.7817 (0.8); 2.7528 (7.9); 2.7270 (0.6); 2.6744 (1.1); 2.6697 (1.7); 2.6650 (1.4); 2.6240 (1.3); 2.6048 (3.0); 2.5853 (3.6); 2.5656 (2.0); 2.5232 (4.0); 2.5184 (6.3); 2.5098 (95.5); 2.5052 (207.9); 2.5006 (289.3); 2.4960 (203.2); 2.4914 (92.1); 2.4510 (1.7); 2.4438 (1.7); 2.4222 (1.0); 2.3797 (0.9); 2.3563 (1.0); 2.3323 (1.4); 2.3275 (1.8); 2.3227 (1.3); 2.2675 (0.9); 2.2572 (1.0); 2.2430 (1.3); 2.2329 (1.0); 2.2166 (0.7); 2.2017 (0.8); 2.1924 (0.7); 2.1171 (0.8); 2.0936 (0.8); 2.0859 (1.0); 2.0729 (0.7); 2.0629 (0.8); 1.6652 (0.9); 1.6568 (0.8); 1.6493 (0.6); 1.6340 (0.7); 1.1688 (0.6); 1.1538 (0.8); 1.1394 (4.5); 1.1281 (2.7); 1.1207 (10.2); 1.1095 (5.6); 1.1019 (4.6); 1.0905 (2.3); 0.0080 (2.3); -0.0002 (87.3); -0.0085 (2.8) I.1-420: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4218 (1.1); 7.4038 (2.9); 7.3850 (2.4); 7.3608 (1.0); 7.3437 (0.9); 7.1807 (4.5); 7.1770 (6.3); 7.1714 (2.9); 7.1595 (4.5); 7.1508 (1.5); 7.0673 (2.3); 7.0484 (1.6); 6.8775 (2.1); 6.8541 (0.9); 4.4165 (0.8); 4.3787 (0.9); 3.9651 (0.9); 3.9264 (0.8); 3.7882 (0.9); 3.7785 (1.0); 3.7689 (0.9); 3.7582 (0.6); 3.6080 (2.0); 3.1038 (6.3); 2.5235 (1.5); 2.5188 (2.1); 2.5101 (25.4); 2.5055 (54.6); 2.5009 (75.9); 2.4963 (53.0); 2.4918 (23.7); 2.4182 (0.7); 2.3845 (0.8); 2.3277 (0.5); 2.2617 (16.0); 2.2266 (1.4); 2.2128 (1.4); 2.1208 (0.7); 2.1010 (0.8); 2.0892 (0.8); 2.0733 (1.1); 2.0321 (0.5); 2.0114 (0.6); 1.6176 (0.6); -0.0002 (15.1) I.1-421: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1892 (1.1); 8.1860 (0.6); 8.1740 (0.6); 8.1708 (1.1); 7.2303 (0.7); 7.2116 (1.7); 7.1929 (1.0); 7.0782 (1.0); 7.0594 (0.7); 7.0246 (1.5); 7.0113 (1.0); 6.9918 (0.8); 6.8744 (1.1); 6.8710 (0.6); 6.8598 (0.6); 6.8560 (1.1); 5.3212 (1.8); 4.6616 (1.0); 4.6230 (1.1); 4.0322 (1.1); 3.9937 (1.0); 3.7446 (0.5); 3.4001 (0.6); 3.3884 (0.6); 3.3777 (0.7); 3.3692 (0.8); 3.3573 (1.1); 3.3202 (1.9); 3.2996 (1.8); 3.2634 (0.9); 3.2211 (0.7); 3.1147 (16.0); 3.1099 (5.7); 3.0895 (1.2); 3.0711 (1.2); 3.0596 (11.0); 3.0305 (0.7); 3.0155 (0.7); 3.0014 (0.6); 2.9976 (0.6); 2.9835 (0.6); 2.9304 (0.7); 2.6843 (1.7); 2.6358 (0.7); 2.6250 (0.7); 2.5986 (0.8); 2.5878 (0.8); 2.5234 (1.2); 2.5187 (1.8); 2.5100 (23.5); 2.5055 (50.2); 2.5009 (69.7); 2.4963 (49.0); 2.4917 (22.1); 2.3773 (0.6); 2.3579 (0.6); 2.3329 (0.7); 2.3276 (0.7); 2.2875 (9.1); 2.2763 (0.8); 2.2649 (0.8); 2.2539 (1.1); 2.2320 (0.9); 2.2231 (0.5); 2.2172 (0.8); 2.1948 (0.7); 2.0967 (0.5); 2.0731 (0.6); 1.1864 (0.8); 1.1682 (1.6); 1.1499 (0.8); 0.9981 (1.1); 0.9835 (0.8); 0.9801 (2.4); 0.9622 (1.1); 0.0080 (0.8); -0.0002 (27.8); -0.0086 (0.8) I.1-422: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2095 (2.2); 7.2052 (1.7); 7.1893 (4.3); 7.1850 (2.3); 7.1443 (3.5); 7.1238 (1.9); 7.1163 (1.6); 7.0959 (0.9); 4.6986 (1.3); 4.6605 (1.4); 4.1738 (2.4); 4.0683 (1.3); 4.0305 (5.4); 3.9855 (0.7); 3.9472 (0.5); 3.7531 (0.5); 3.7407 (0.7); 3.7308 (0.7); 3.7209 (0.5); 3.6748 (7.0); 3.6167 (15.6); 2.9250 (14.2); 2.8763 (0.9); 2.8591 (1.2); 2.8419 (0.9); 2.8028 (0.7); 2.7929 (0.7); 2.7675 (5.3); 2.7526 (0.8); 2.5190 (0.6); 2.5103 (9.4); 2.5057 (20.6); 2.5011 (28.7); 2.4965 (20.3); 2.4919 (9.3); 2.4645 (0.9); 2.4474 (0.8); 2.4243 (0.8); 2.4193 (0.6); 2.3996 (0.6); 2.3409 (0.6); 2.2518 (0.5); 2.2397 (0.7); 2.2273 (0.6); 2.0839 (0.6); 1.1957 (7.8); 1.1912 (16.0); 1.1784 (8.0); 1.1739 (15.7); -0.0002 (2.1) I.1-423: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.6982 (0.5); 7.8200 (5.7); 7.1861 (1.8); 7.1787 (8.0); 7.1728 (3.8); 7.1640 (1.7); 7.1559 (0.9); 7.1192 (1.0); 7.1085 (0.9); 4.7434 (1.3); 4.7036 (1.4); 4.1010 (1.3); 4.0612 (1.2); 3.8091 (0.6); 3.7991 (0.6); 3.7867 (0.8); 3.7771 (0.7); 3.7667 (0.6); 3.5767 (16.0); 3.3796 (121.0); 3.1677 (1.6); 2.8463 (0.6); 2.8376 (0.6); 2.8098 (0.8); 2.7996 (0.8); 2.7669 (1.4); 2.7546 (1.4); 2.6747 (1.2); 2.6701 (1.7); 2.6655 (1.1); 2.5437 (1.7); 2.5393 (2.3); 2.5345 (2.8); 2.5297 (2.7); 2.5236 (5.2); 2.5188 (7.2); 2.5102 (92.1); 2.5056 (197.8); 2.5010 (274.6); 2.4964 (192.3); 2.4918 (86.1); 2.4752 (0.8); 2.4489 (0.9); 2.4283 (1.0); 2.4072 (0.7); 2.3507 (0.6); 2.3374 (0.9); 2.3325 (1.4); 2.3276 (2.3); 2.3233 (1.5); 2.3147 (1.0); 2.2841 (0.6); 2.2738 (0.7); 2.2408 (13.8); 2.2303 (2.4); 2.2104 (0.5); 2.1979 (0.6); 2.1901 (0.7); 2.1663 (0.5); 1.8481 (0.6); 1.8374 (0.6); 1.0646 (0.6); 1.0466 (1.4); 1.0287 (0.6); 0.0080 (1.4); -0.0002 (50.8); -0.0085 (1.5) I.1-424: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1788 (2.0); 7.1634 (1.4); 7.1580 (6.7); 7.1404 (6.8); 7.1198 (2.0); 4.6950 (1.8); 4.6568 (2.0); 4.0328 (1.9); 3.9947 (1.7); 3.6934 (0.6); 3.6833 (0.8); 3.6737 (0.8); 3.6703 (0.8); 3.6608 (0.8); 3.6508 (0.6); 3.3385 (1.0); 2.7050 (1.4); 2.6955 (1.4); 2.6655 (1.8); 2.6560 (1.6); 2.6066 (1.1); 2.5877 (3.6); 2.5687 (3.7); 2.5497 (1.2); 2.5105 (4.9); 2.5059 (10.8); 2.5013 (15.0); 2.4967 (10.6); 2.4921 (4.8); 2.3946 (1.0); 2.3765 (0.7); 2.3711 (0.7); 2.3532 (0.7); 2.3169 (1.8); 2.2937 (1.7); 2.2827 (0.8); 2.2775 (1.6); 2.2690 (0.9); 2.2581 (1.3); 2.2543 (1.6); 2.2445 (1.1); 2.2164 (0.7); 2.2033 (0.7); 2.1504 (0.6); 2.1380 (0.5); 2.1196 (0.7); 2.0943 (0.5); 1.7120 (0.6); 1.7008 (0.8); 1.6899 (0.6); 1.6805 (0.6); 1.6690 (0.7); 1.1828 (6.9); 1.1639 (16.0); 1.1449 (6.8); -0.0002 (0.8) I.1-425: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2311 (1.4); 7.2273 (1.7); 7.2199 (2.5); 7.2164 (4.0); 7.2132 (5.9); 7.2011 (0.8); 7.1818 (1.1); 7.1751 (1.0); 7.1629 (1.8); 7.1555 (1.8); 7.1489 (1.0); 7.1415 (1.2); 7.1241 (2.4); 7.1061 (1.2); 4.7703 (2.2); 4.7312 (2.4); 4.0959 (2.1); 4.0568 (1.9); 3.7185 (0.5); 3.6846 (0.8); 3.6756 (1.2); 3.6661 (1.0); 3.6614 (1.0); 3.6552 (1.3); 3.6525 (1.4); 3.6466 (0.9); 3.6418 (1.0); 3.6322 (1.0); 3.6234 (0.6); 2.6804 (1.4); 2.6712 (1.5); 2.6408 (1.9); 2.6316 (1.8); 2.6248 (0.9); 2.6206 (0.9); 2.6061 (2.4); 2.6017 (2.5); 2.5871 (2.5); 2.5831 (2.7); 2.5681 (0.9); 2.5646 (1.0); 2.5109 (4.5); 2.5063 (10.0); 2.5017 (14.2); 2.4971 (10.0); 2.4925 (4.5); 2.4835 (0.5); 2.4604 (0.7); 2.4401 (1.0); 2.4194 (1.1); 2.3974 (0.7); 2.3596 (2.1); 2.3362 (2.0); 2.3200 (1.7); 2.2965 (1.8); 2.2936 (1.0); 2.2821 (0.9); 2.2685 (1.2); 2.2575 (1.2); 2.2515 (0.6); 2.2407 (0.5); 2.2267 (0.8); 2.2161 (0.8); 2.1618 (0.8); 2.1501 (0.6); 2.1372 (0.6); 2.1298 (1.0); 2.1257 (0.5); 2.1094 (0.6); 2.1053 (0.7); 2.0853 (0.6); 1.7553 (0.6); 1.7419 (0.5); 1.7333 (0.9); 1.7231 (0.9); 1.7141 (0.5); 1.1423 (6.8); 1.1235 (16.0); 1.1046 (6.7); -0.0002 (2.1) I.1-431: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5189 (11.8); 7.3098 (3.4); 7.2977 (1.7); 7.2938 (1.5); 7.2913 (1.9); 7.2866 (2.1); 7.2850 (2.2); 7.2826 (2.5); 7.2802 (3.0); 7.2786 (2.6); 7.2770 (2.9); 7.2754 (3.2); 7.2746 (3.3); 7.2738 (3.7); 7.2730 (3.9); 7.2722 (4.3); 7.2706 (6.3); 7.2699 (6.5); 7.2691 (6.7); 7.2674 (10.4); 7.2666 (12.2); 7.2650 (19.2); 7.2600 (2279.1); 7.2095 (4.8); 7.1443 (5.4); 7.1388 (2.6); 7.1309 (5.6); 7.1224 (7.5); 7.1090 (7.3); 7.0998 (3.0); 7.0827 (2.2); 7.0733 (2.5); 7.0540 (8.4); 7.0439 (5.6); 7.0403 (8.6); 7.0296 (3.9); 7.0159 (9.1); 7.0104 (3.0); 6.9959 (16.0); 6.9941 (15.8); 6.9777 (2.3); 6.9723 (6.0); 5.3388 (1.7); 4.8461 (3.4); 4.8112 (3.9); 4.2304 (5.1); 4.1914 (4.6); 3.9189 (1.5); 3.9078 (2.2); 3.8983 (2.2); 3.8877 (2.2); 3.8767 (1.6); 3.7384 (3.2); 3.5069 (2.4); 3.5019 (2.2); 3.4890 (5.4); 3.4741 (4.7); 3.4699 (5.6); 3.4564 (2.4); 3.4528 (2.3); 2.7895 (5.4); 2.7716 (10.9); 2.7542 (5.0); 2.5815 (3.7); 2.5704 (3.7); 2.5453 (4.2); 2.5345 (4.2); 2.4752 (2.6); 2.4502 (2.2); 2.4334 (2.4); 2.4206 (2.5); 2.4057 (3.0); 2.3964 (3.9); 2.3819 (3.5); 2.3534 (1.6); 2.3390 (1.8); 2.2707 (1.3); 2.2513 (2.1); 2.2379 (1.8); 2.2273 (1.7); 2.2189 (2.1); 2.2009 (4.2); 2.1943 (1.9); 2.1236 (4.5); 2.1012 (4.7); 2.0874 (4.0); 2.0650 (3.8); 1.8074 (1.4); 1.7972 (1.8); 1.7886 (1.5); 1.7745 (1.6); 1.7631 (1.4); 1.7540 (1.3); 1.5442 (113.1); 1.4634 (2.2); 1.3860 (2.2); 0.0079 (4.9); -0.0002 (178.1); -0.0085 (5.8) I.1-433: 1H-NMR (400.0 MHz, d6-DMSO): δ= 10.6262 (0.8); 8.0512 (0.7); 7.2229 (1.9); 7.2219 (1.9); 7.2012 (2.2); 7.2001 (2.2); 7.1827 (0.5); 7.1701 (0.5); 7.0787 (1.4); 7.0728 (1.5); 7.0515 (0.6); 6.9969 (1.6); 6.9908 (1.6); 6.7182 (1.2); 6.7123 (1.1); 6.6964 (1.0); 6.6905 (1.0); 4.7360 (0.7); 4.6960 (0.8); 4.2301 (0.9); 4.1903 (0.8); 3.7837 (0.5); 3.7457 (16.0); 3.3965 (17.0); 3.3117 (0.9); 3.2930 (0.9); 2.7656 (0.9); 2.7469 (1.4); 2.7290 (0.8); 2.5236 (0.5); 2.5103 (11.5); 2.5057 (25.4); 2.5011 (34.9); 2.4965 (24.5); 2.4919 (10.9); 2.4831 (1.0); 2.4713 (0.8); 2.3420 (0.5); 2.3231 (0.6); 2.2446 (0.6); 2.2313 (0.6); 2.1974 (0.8); 2.1759 (0.7); 2.1626 (0.6); 2.1411 (0.6); 2.0730 (0.7); -0.0002 (1.6) I.1-434: 1H-NMR (400.0 MHz, d6-DMSO): δ= 11.8018 (6.5); 8.5752 (1.6); 8.3106 (16.0); 8.3089 (15.9); 8.3062 (13.2); 8.3044 (15.9); 7.7392 (3.6); 7.7329 (3.6); 7.7185 (7.5); 7.7158 (9.0); 7.7123 (8.0); 7.7095 (8.1); 7.6951 (9.5); 7.6888 (8.8); 7.5018 (14.4); 7.5003 (14.2); 7.4950 (4.5); 7.4935 (4.4); 7.4895 (7.1); 7.4879 (7.2); 7.4812 (12.4); 7.4797 (12.2); 7.4744 (3.4); 7.4730 (3.4); 7.4689 (5.4); 7.4674 (5.8); 4.8581 (0.9); 4.8394 (1.9); 4.8246 (2.4); 4.8075 (2.1); 4.7893 (0.9); 4.6424 (2.1); 4.6078 (8.1); 4.5685 (9.4); 4.3376 (0.7); 4.3109 (6.6); 4.2963 (6.9); 4.2712 (0.8); 4.2266 (2.7); 4.2161 (8.9); 4.1875 (2.2); 4.1767 (7.4); 3.9641 (3.2); 3.8599 (1.7); 3.8488 (3.1); 3.8382 (4.0); 3.8285 (4.7); 3.8186 (4.1); 3.8079 (3.3); 3.7965 (2.0); 3.7732 (1.7); 3.7622 (2.1); 3.7509 (2.4); 3.7419 (2.4); 3.7318 (2.6); 3.6391 (8.7); 3.5770 (3.7); 3.3928 (0.6); 3.2705 (0.6); 3.2206 (76.9); 3.1960 (1.4); 3.1652 (4.7); 3.0450 (0.7); 2.9093 (1.6); 2.7732 (0.8); 2.7648 (0.7); 2.7490 (4.8); 2.7379 (4.8); 2.7104 (6.2); 2.6994 (5.7); 2.6732 (3.2); 2.6702 (3.8); 2.6655 (2.6); 2.6624 (2.4); 2.6421 (0.5); 2.6039 (1.2); 2.5872 (0.8); 2.5671 (5.9); 2.5554 (7.9); 2.5491 (7.0); 2.5462 (4.1); 2.5406 (9.2); 2.5236 (7.8); 2.5191 (13.8); 2.5103 (170.6); 2.5057 (377.6); 2.5011 (530.9); 2.4965 (373.4); 2.4919 (166.5); 2.4765 (5.4); 2.4648 (4.2); 2.4587 (0.7); 2.4534 (2.8); 2.4444 (1.2); 2.4327 (2.2); 2.4279 (2.3); 2.4209 (2.4); 2.4096 (4.3); 2.4030 (2.9); 2.3928 (6.7); 2.3863 (5.0); 2.3703 (9.9); 2.3629 (4.2); 2.3541 (5.7); 2.3477 (4.1); 2.3325 (7.5); 2.3279 (5.2); 2.3233 (2.9); 2.3157 (1.6); 2.3079 (2.9); 2.3040 (3.8); 2.2986 (2.2); 2.2956 (2.8); 2.2912 (4.4); 2.2842 (2.9); 2.2804 (6.2); 2.2670 (6.2); 2.2554 (2.4); 2.2497 (1.6); 2.2433 (1.5); 2.2387 (3.0); 2.2260 (3.4); 2.2175 (1.8); 2.2100 (2.4); 2.1911 (3.2); 2.1790 (2.6); 2.1727 (2.6); 2.1672 (2.5); 2.1602 (3.6); 2.1549 (2.2); 2.1486 (1.7); 2.1414 (2.0); 2.1359 (2.2); 2.1171 (1.1); 2.0735 (0.6); 1.9304 (1.2); 1.9113 (1.2); 1.9073 (2.3); 1.8990 (1.1); 1.8882 (2.2); 1.8843 (1.2); 1.8798 (1.2); 1.8759 (1.9); 1.8652 (1.1); 1.8568 (1.8); 1.8531 (1.0); 1.8337 (0.8); 1.7547 (1.5); 1.7425 (2.7); 1.7315 (3.8); 1.7208 (3.2); 1.7116 (3.2); 1.7000 (3.1); 1.6891 (2.5); 1.6756 (1.8); 1.0471 (0.6); 0.1458 (0.8); 0.0495 (2.7); 0.0081 (8.2); -0.0002 (288.1); -0.0086 (7.9); -0.1496 (0.8) I.1-435: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3377 (2.2); 8.3316 (2.3); 8.3079 (0.5); 7.8272 (4.6); 7.7406 (1.4); 7.7343 (1.4); 7.7198 (1.8); 7.7136 (1.8); 7.5038 (3.0); 7.4932 (0.7); 7.4833 (2.6); 7.4727 (0.6); 4.6706 (1.3); 4.6320 (1.6); 4.2586 (1.9); 4.2194 (1.7); 3.9041 (0.8); 3.8939 (1.1); 3.8826 (1.1); 3.8738 (1.1); 3.8631 (1.0); 3.7461 (1.6); 3.6323 (1.2); 3.6007 (16.0); 3.1649 (1.0); 2.8970 (0.6); 2.8607 (0.6); 2.6700 (1.1); 2.6653 (0.8); 2.5403 (0.9); 2.5234 (2.6); 2.5188 (3.8); 2.5101 (64.9); 2.5055 (143.2); 2.5009 (200.3); 2.4963 (140.5); 2.4917 (62.7); 2.4631 (1.2); 2.4380 (1.0); 2.4133 (1.1); 2.3952 (1.1); 2.3712 (0.9); 2.3279 (1.7); 2.3146 (0.8); 2.3044 (1.0); 2.2900 (1.0); 2.2629 (0.6); 2.2497 (0.6); 2.2360 (0.5); 2.2177 (0.7); 2.1877 (0.7); 2.1693 (0.6); 1.8254 (0.6); 1.8135 (0.6); 1.7948 (0.6); 0.0079 (3.0); -0.0002 (102.0); -0.0085 (2.9) I.1-436: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3178 (1.1); 8.3117 (1.7); 8.2956 (2.4); 8.1843 (0.5); 8.1623 (0.5); 8.1018 (0.6); 8.0803 (0.6); 8.0579 (0.6); 8.0369 (0.6); 7.7244 (0.8); 7.7179 (1.3); 7.7096 (1.0); 7.7034 (1.9); 7.6975 (1.9); 7.6892 (1.2); 7.6828 (1.2); 7.6784 (0.8); 7.4968 (3.1); 7.4764 (2.8); 4.6618 (1.0); 4.6472 (0.7); 4.6391 (0.5); 4.6230 (1.2); 4.6086 (0.8); 4.5998 (0.6); 4.3897 (0.6); 4.3784 (0.6); 4.3678 (0.6); 4.3562 (0.7); 4.3507 (0.6); 4.3391 (0.6); 4.3290 (0.6); 4.3173 (0.8); 4.2333 (0.8); 4.2128 (2.1); 4.1933 (1.2); 4.1869 (0.8); 4.1733 (2.0); 4.1651 (0.6); 3.7733 (0.9); 3.7618 (0.9); 3.3777 (8.6); 2.6705 (1.0); 2.6607 (0.6); 2.6369 (0.6); 2.6257 (0.5); 2.6034 (0.9); 2.5821 (0.6); 2.5686 (1.0); 2.5405 (0.6); 2.5238 (1.5); 2.5191 (2.3); 2.5104 (39.0); 2.5059 (86.2); 2.5012 (120.5); 2.4966 (83.7); 2.4920 (37.2); 2.3555 (0.9); 2.3496 (1.1); 2.3328 (1.6); 2.3280 (1.9); 2.3082 (1.2); 2.2936 (1.3); 2.2732 (1.9); 2.2650 (1.1); 2.2515 (1.5); 2.2377 (0.8); 2.2234 (0.5); 2.2091 (0.5); 2.0914 (0.6); 2.0784 (0.7); 2.0675 (0.8); 2.0603 (0.8); 1.8609 (0.6); 1.8430 (0.6); 1.7444 (0.9); 1.2573 (0.5); 1.2423 (0.6); 1.1631 (0.5); 1.1451 (0.6); 1.1330 (0.6); 1.1149 (0.5); 0.8502 (10.5); 0.8333 (16.0); 0.8154 (4.4); 0.0079 (1.7); -0.0002 (55.5); -0.0085 (1.6) I.1-437: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5763 (0.7); 8.3150 (12.6); 8.3137 (14.0); 8.3089 (13.7); 8.3074 (13.7); 8.2979 (1.1); 8.2914 (0.9); 7.7399 (1.6); 7.7337 (1.6); 7.7193 (10.2); 7.7130 (9.9); 7.6986 (10.3); 7.6923 (9.9); 7.4951 (16.0); 7.4936 (16.0); 7.4897 (3.9); 7.4880 (3.5); 7.4746 (13.6); 7.4731 (13.6); 7.4691 (3.0); 7.4675 (2.8); 7.4605 (0.6); 5.5893 (0.5); 4.8408 (0.9); 4.8255 (1.1); 4.8084 (1.0); 4.6435 (9.1); 4.6042 (11.0); 4.3379 (0.8); 4.3223 (1.0); 4.3118 (3.5); 4.2972 (3.6); 4.2723 (1.7); 4.2577 (1.5); 4.2275 (11.1); 4.1883 (9.8); 4.0855 (2.2); 3.8233 (0.6); 3.7849 (1.9); 3.7740 (3.1); 3.7631 (4.4); 3.7537 (4.5); 3.7434 (4.2); 3.7327 (3.2); 3.7216 (1.6); 3.1675 (1.0); 2.9874 (0.5); 2.9260 (0.6); 2.7131 (7.1); 2.7027 (7.3); 2.6730 (9.3); 2.6626 (8.8); 2.5682 (2.4); 2.5652 (1.2); 2.5564 (2.5); 2.5501 (2.6); 2.5415 (3.7); 2.5330 (0.7); 2.5246 (2.6); 2.5202 (5.2); 2.5112 (61.4); 2.5067 (136.8); 2.5020 (193.1); 2.4974 (137.1); 2.4928 (61.3); 2.4774 (2.3); 2.4655 (1.8); 2.4586 (0.7); 2.4541 (1.8); 2.4451 (0.8); 2.4368 (2.0); 2.4205 (2.5); 2.4107 (2.8); 2.3957 (5.3); 2.3784 (4.3); 2.3701 (12.5); 2.3566 (3.5); 2.3482 (9.3); 2.3300 (8.7); 2.3164 (1.1); 2.3082 (8.1); 2.2956 (3.9); 2.2814 (4.2); 2.2710 (6.1); 2.2571 (6.1); 2.2441 (0.9); 2.2411 (0.9); 2.2295 (3.9); 2.2181 (6.2); 2.2038 (2.7); 2.2009 (3.2); 2.1897 (3.1); 2.1846 (2.6); 2.1797 (1.6); 2.1764 (2.0); 2.1726 (3.5); 2.1654 (2.2); 2.1603 (1.6); 2.1530 (2.5); 2.1461 (2.2); 2.1286 (1.4); 1.9082 (1.0); 1.8891 (1.0); 1.8851 (0.6); 1.8807 (0.5); 1.8768 (0.8); 1.8577 (0.8); 1.7426 (1.7); 1.7327 (3.3); 1.7212 (3.7); 1.7145 (2.3); 1.7103 (2.9); 1.7036 (3.6); 1.6966 (2.2); 1.6903 (3.6); 1.6786 (2.4); 1.6650 (1.6); 0.0080 (4.2); 0.0064 (1.1); 0.0055 (1.2); 0.0047 (1.4); 0.0039 (1.9); 0.0022 (5.7); -0.0002 (148.7); -0.0026 (9.6); -0.0051 (2.7); - 0.0059 (2.0); -0.0068 (1.7); -0.0085 (4.6); -0.0107 (1.0); -0.0115 (0.9); -0.0123 (0.7); -0.0131 (0.7); - 0.0139 (0.6); -0.0147 (0.6); -0.0155 (0.5) I.1-438: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9047 (2.5); 8.8833 (2.5); 8.2435 (4.2); 8.2384 (4.2); 7.6532 (2.7); 7.6469 (2.6); 7.6326 (3.2); 7.6263 (3.2); 7.4570 (5.4); 7.4556 (5.5); 7.4365 (4.6); 7.4351 (4.6); 7.3496 (3.0); 7.3453 (2.4); 7.3430 (3.0); 7.3393 (1.9); 7.3288 (7.4); 7.3242 (5.6); 7.3218 (6.3); 7.3129 (7.2); 7.3062 (7.0); 7.2897 (0.5); 7.2632 (12.6); 7.2551 (11.2); 7.2450 (8.9); 7.2377 (7.7); 7.2326 (4.1); 7.2269 (1.9); 7.2233 (1.5); 7.2197 (1.4); 6.1111 (3.0); 6.0899 (3.0); 4.6195 (2.8); 4.5802 (3.3); 4.1498 (3.2); 4.1108 (2.8); 3.9640 (0.7); 3.8213 (0.9); 3.8125 (1.0); 3.8013 (1.7); 3.7895 (1.1); 3.7813 (1.0); 3.5550 (2.6); 3.1653 (16.0); 2.6830 (1.8); 2.6705 (2.3); 2.6479 (2.1); 2.6358 (2.0); 2.5506 (0.6); 2.5402 (0.5); 2.5234 (1.6); 2.5187 (2.4); 2.5100 (40.0); 2.5054 (88.3); 2.5008 (123.5); 2.4962 (86.5); 2.4916 (38.4); 2.3418 (2.2); 2.3279 (2.3); 2.3209 (2.4); 2.3065 (2.9); 2.2857 (2.8); 2.2770 (1.3); 2.2622 (1.5); 2.2532 (1.7); 2.2383 (1.7); 2.2201 (0.5); 2.2115 (0.7); 2.1967 (0.7); 2.1151 (0.6); 2.0963 (0.9); 2.0833 (0.8); 2.0723 (1.0); 2.0651 (1.1); 2.0539 (0.5); 2.0408 (0.8); 1.7296 (0.8); 1.7189 (0.8); 1.7091 (0.9); 1.6977 (0.9); 1.6863 (0.8); 1.6774 (0.6); 0.0080 (1.7); -0.0002 (60.1); -0.0086 (1.6) I.1-439: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4189 (0.6); 7.4005 (1.5); 7.3817 (1.3); 7.3540 (0.5); 7.1708 (3.6); 7.1510 (3.3); 7.0121 (1.1); 6.9940 (0.9); 3.7781 (0.5); 3.5027 (0.9); 3.1068 (3.4); 2.8819 (0.8); 2.8645 (1.1); 2.8472 (0.9); 2.5188 (0.7); 2.5101 (11.3); 2.5056 (24.8); 2.5010 (34.7); 2.4964 (24.4); 2.4918 (11.0); 2.2013 (0.8); 2.0733 (0.9); 1.2036 (16.0); 1.1863 (15.8); -0.0002 (12.7) I.1-440: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2104 (2.4); 7.1902 (4.3); 7.1437 (2.8); 7.1274 (1.7); 7.1236 (1.8); 7.1067 (0.9); 5.0578 (0.6); 5.0489 (0.5); 4.7482 (0.6); 4.7106 (0.8); 4.6526 (0.6); 4.1683 (0.6); 4.1507 (0.9); 4.1332 (0.7); 4.1256 (0.5); 4.1131 (0.8); 4.1081 (1.0); 4.1059 (1.0); 4.0954 (2.5); 4.0905 (1.0); 4.0881 (0.8); 4.0776 (2.2); 4.0598 (1.1); 4.0554 (0.8); 4.0164 (1.0); 3.7391 (0.5); 3.7287 (0.6); 3.7183 (0.6); 3.7047 (0.5); 3.6945 (0.6); 3.6017 (2.4); 2.8766 (0.8); 2.8594 (1.2); 2.8426 (0.8); 2.5293 (0.5); 2.5234 (1.3); 2.5187 (1.7); 2.5100 (24.2); 2.5054 (52.9); 2.5008 (74.0); 2.4962 (52.5); 2.4917 (23.7); 2.4325 (0.7); 2.4126 (0.7); 2.3902 (0.9); 2.3728 (0.6); 2.2704 (0.6); 2.2585 (0.5); 2.2465 (0.7); 2.2341 (0.7); 2.2055 (0.5); 2.1090 (0.7); 2.0961 (0.6); 2.0850 (0.8); 2.0771 (0.9); 2.0732 (0.8); 2.0522 (0.6); 1.6416 (0.6); 1.6301 (0.7); 1.6113 (0.7); 1.5995 (0.7); 1.5880 (0.8); 1.5477 (0.6); 1.5297 (0.5); 1.2171 (1.8); 1.1993 (3.9); 1.1950 (6.2); 1.1894 (13.7); 1.1814 (3.0); 1.1778 (6.5); 1.1718 (16.0); 1.1610 (1.7); 1.1531 (6.2); 1.1432 (0.8); 1.1352 (2.4); - 0.0002 (5.3) I.1-441: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8259 (4.8); 7.2164 (1.6); 7.1961 (4.0); 7.1678 (3.2); 7.1470 (1.4); 4.7298 (1.0); 4.6916 (1.1); 4.0565 (1.0); 4.0182 (0.9); 3.8080 (0.6); 3.5911 (12.5); 3.5066 (11.8); 3.1677 (1.5); 2.8808 (1.0); 2.8632 (1.0); 2.8460 (1.1); 2.6743 (1.0); 2.6700 (1.2); 2.6651 (0.8); 2.5232 (3.2); 2.5186 (4.8); 2.5099 (78.0); 2.5053 (170.2); 2.5007 (237.2); 2.4961 (167.3); 2.4916 (75.2); 2.4488 (0.9); 2.4311 (0.6); 2.4120 (0.7); 2.3900 (0.7); 2.3712 (0.5); 2.3320 (1.0); 2.3275 (1.4); 2.3231 (1.1); 2.3043 (0.6); 2.2938 (0.6); 2.2798 (0.7); 2.1411 (0.6); 2.0731 (0.7); 1.1946 (16.0); 1.1774 (15.7); -0.0002 (12.5) I.1-442: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2275 (1.2); 7.2237 (1.5); 7.2181 (1.5); 7.2122 (3.8); 7.2102 (4.1); 7.1805 (0.6); 7.1734 (0.8); 7.1616 (1.0); 7.1537 (1.2); 7.1486 (0.9); 7.1403 (0.9); 7.1267 (1.4); 7.1087 (0.6); 7.0874 (0.6); 4.7820 (1.4); 4.7431 (1.6); 4.1869 (2.4); 4.1179 (1.1); 4.0789 (1.0); 4.0380 (0.6); 4.0254 (3.2); 4.0180 (3.1); 3.7118 (0.6); 3.6994 (0.5); 3.6917 (0.5); 3.6708 (7.8); 3.6113 (16.0); 3.4035 (20.6); 2.9426 (14.5); 2.8002 (0.6); 2.7913 (0.6); 2.7550 (5.7); 2.6698 (0.6); 2.6222 (0.7); 2.6034 (2.4); 2.5848 (2.9); 2.5660 (1.6); 2.5465 (1.0); 2.5401 (0.9); 2.5342 (1.3); 2.5233 (1.9); 2.5186 (2.7); 2.5100 (36.7); 2.5054 (77.7); 2.5008 (108.3); 2.4961 (76.0); 2.4915 (33.8); 2.4700 (0.9); 2.4443 (0.8); 2.4389 (0.5); 2.4223 (0.6); 2.3323 (0.5); 2.3276 (0.7); 2.3230 (0.7); 2.2598 (0.5); 2.2450 (0.7); 2.2351 (0.6); 2.0865 (0.6); 1.6615 (0.5); 1.6523 (0.6); 1.1399 (3.6); 1.1296 (1.9); 1.1211 (8.4); 1.1109 (4.0); 1.1022 (3.5); 1.0920 (1.6); -0.0002 (8.8) I.1-443: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.1789 (1.8); 7.1716 (6.4); 7.1660 (4.5); 7.1559 (1.5); 7.1492 (1.0); 7.1425 (0.7); 7.1169 (1.0); 7.1053 (0.8); 7.0826 (0.5); 4.7268 (1.6); 4.6874 (1.8); 4.1824 (2.5); 4.0990 (1.2); 4.0596 (1.1); 4.0236 (4.0); 4.0179 (3.6); 3.9828 (0.5); 3.7116 (0.7); 3.7011 (0.6); 3.6913 (0.6); 3.6722 (7.6); 3.6117 (16.0); 3.1680 (0.6); 2.9380 (14.8); 2.7978 (0.6); 2.7884 (0.6); 2.7551 (6.0); 2.7484 (1.0); 2.5369 (1.0); 2.5334 (0.5); 2.5233 (1.1); 2.5186 (1.4); 2.5100 (14.3); 2.5054 (29.9); 2.5008 (41.2); 2.4962 (29.0); 2.4916 (12.4); 2.4726 (0.6); 2.4583 (0.6); 2.4381 (0.7); 2.3878 (0.6); 2.2704 (0.6); 2.2564 (0.8); 2.2509 (0.6); 2.2460 (0.8); 2.2396 (0.7); 2.2231 (11.0); 2.2147 (1.0); 2.2078 (5.3); 2.1474 (0.6); 2.1156 (0.6); 1.6612 (0.5); 1.6518 (0.6); 0.0080 (0.5); -0.0002 (15.7) I.1-444: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2065 (1.5); 7.1979 (1.4); 7.1863 (3.2); 7.1777 (2.1); 7.1451 (2.6); 7.1245 (1.4); 7.1167 (1.9); 7.0963 (1.2); 4.7035 (0.8); 4.6980 (0.9); 4.6658 (0.8); 4.6600 (1.0); 4.0717 (0.9); 4.0336 (0.9); 3.9479 (0.7); 3.9099 (0.7); 3.8923 (4.2); 3.8663 (1.4); 3.8630 (1.4); 3.7538 (0.5); 3.7437 (0.7); 3.7338 (0.7); 3.7239 (0.6); 2.9765 (0.7); 2.9673 (3.4); 2.9515 (0.7); 2.8942 (9.3); 2.8739 (1.1); 2.8565 (1.6); 2.8511 (1.6); 2.8392 (1.7); 2.8300 (3.2); 2.8124 (3.8); 2.7940 (1.3); 2.7818 (0.7); 2.7720 (1.0); 2.7483 (5.9); 2.7415 (1.0); 2.7386 (1.0); 2.7317 (0.7); 2.7101 (0.6); 2.6701 (0.6); 2.5189 (0.8); 2.5102 (13.6); 2.5056 (30.0); 2.5010 (42.0); 2.4965 (29.9); 2.4919 (13.6); 2.4545 (0.8); 2.4314 (0.8); 2.4143 (1.0); 2.3912 (0.9); 2.3122 (0.7); 2.2888 (0.5); 2.2476 (0.8); 2.2353 (0.7); 2.2230 (0.9); 2.1816 (0.5); 2.0812 (0.6); 1.1934 (10.3); 1.1907 (13.4); 1.1761 (10.3); 1.1734 (13.1); 1.0943 (7.8); 1.0762 (16.0); 1.0581 (7.6); -0.0002 (3.1) I.1-445: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.4171 (2.4); 7.3988 (5.9); 7.3801 (5.0); 7.3564 (2.1); 7.2401 (1.5); 7.2213 (4.5); 7.2010 (5.8); 7.1896 (5.8); 7.1639 (11.1); 7.1602 (16.0); 7.1549 (3.4); 7.1429 (10.7); 7.1399 (10.4); 7.1143 (3.0); 7.0964 (1.5); 6.9331 (2.0); 4.5561 (1.6); 4.5174 (1.8); 3.9547 (1.8); 3.9197 (1.5); 3.7483 (2.0); 3.3705 (0.6); 3.3514 (1.0); 3.3187 (341.0); 3.2683 (1.4); 3.1666 (2.2); 3.0888 (11.4); 2.6747 (1.3); 2.6700 (1.9); 2.6654 (1.4); 2.6608 (0.7); 2.5516 (1.3); 2.5235 (6.4); 2.5187 (8.8); 2.5100 (111.3); 2.5055 (243.2); 2.5008 (342.2); 2.4962 (239.3); 2.4916 (106.5); 2.4501 (1.4); 2.3836 (1.3); 2.3324 (2.6); 2.3277 (2.6); 2.3232 (2.0); 2.2184 (3.2); 2.1778 (1.0); 2.1225 (1.7); 2.0910 (2.6); 2.0730 (3.3); 1.6739 (1.4); 1.2341 (0.6); 1.0961 (6.9); 1.0775 (13.3); 1.0586 (6.4); 0.0080 (0.7); -0.0002 (24.2); -0.0086 (0.7) I.1-446: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8292 (6.0); 7.1878 (0.8); 7.1662 (8.0); 7.1616 (7.5); 7.1398 (0.9); 7.1343 (0.7); 4.7234 (1.3); 4.6851 (1.4); 4.1054 (0.6); 4.0669 (1.9); 4.0486 (0.8); 4.0287 (1.9); 4.0109 (0.8); 3.8244 (0.6); 3.8138 (0.8); 3.8023 (0.8); 3.7924 (0.8); 3.7819 (0.6); 3.5916 (16.0); 3.1119 (0.6); 2.8740 (0.5); 2.8640 (0.6); 2.8369 (0.7); 2.8271 (0.6); 2.7697 (1.1); 2.7573 (1.1); 2.6083 (1.1); 2.5893 (3.5); 2.5703 (3.6); 2.5516 (1.3); 2.5236 (0.6); 2.5189 (1.0); 2.5103 (15.8); 2.5057 (34.8); 2.5011 (49.1); 2.4965 (35.0); 2.4919 (16.0); 2.4760 (1.0); 2.4679 (0.8); 2.4628 (0.9); 2.4377 (0.7); 2.4321 (0.5); 2.4132 (0.8); 2.3945 (0.7); 2.3902 (0.7); 2.3713 (0.6); 2.3171 (0.5); 2.3036 (0.6); 2.2926 (0.8); 2.2793 (0.8); 2.1665 (0.5); 2.1350 (0.6); 1.8130 (0.5); 1.8023 (0.5); 1.7921 (0.5); 1.1833 (5.8); 1.1644 (13.0); 1.1454 (5.7); 1.0511 (0.9); -0.0002 (4.4) I.1-447: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.2344 (1.4); 7.2155 (3.5); 7.1969 (2.3); 7.0832 (2.0); 7.0644 (1.6); 7.0317 (2.1); 7.0145 (1.9); 6.9963 (1.9); 5.0649 (1.0); 5.0571 (1.0); 5.0501 (1.0); 4.7558 (1.0); 4.7175 (1.4); 4.7097 (1.4); 4.6712 (1.7); 4.1706 (0.7); 4.1526 (1.1); 4.1347 (0.9); 4.1252 (1.0); 4.1175 (0.9); 4.1107 (2.0); 4.1075 (2.8); 4.0997 (0.9); 4.0950 (3.2); 4.0898 (2.8); 4.0824 (1.3); 4.0774 (3.1); 4.0722 (0.9); 4.0596 (1.0); 4.0473 (1.2); 4.0075 (1.0); 3.9682 (0.8); 3.7471 (0.7); 3.7419 (0.7); 3.7330 (0.7); 3.7281 (0.7); 3.7188 (0.8); 3.7093 (0.8); 3.6996 (0.6); 3.6719 (0.7); 3.4407 (6.2); 2.8714 (0.7); 2.8617 (0.7); 2.8315 (0.9); 2.8216 (0.9); 2.7779 (0.6); 2.7683 (0.6); 2.6698 (0.6); 2.5287 (1.0); 2.5233 (1.9); 2.5185 (2.6); 2.5099 (32.9); 2.5053 (71.3); 2.5007 (99.0); 2.4961 (69.4); 2.4915 (31.1); 2.4801 (1.0); 2.4644 (1.1); 2.4611 (1.2); 2.4561 (1.3); 2.4514 (1.1); 2.4464 (0.8); 2.4412 (0.9); 2.4208 (1.4); 2.3974 (1.6); 2.3811 (1.2); 2.3582 (0.8); 2.3274 (0.8); 2.3228 (0.6); 2.2856 (16.0); 2.2705 (1.2); 2.2586 (1.3); 2.2460 (1.3); 2.2409 (0.9); 2.2289 (0.6); 2.2166 (0.9); 2.2044 (0.7); 2.1337 (1.0); 2.1207 (0.6); 2.1144 (1.0); 2.1093 (0.9); 2.1013 (1.2); 2.0904 (1.3); 2.0822 (1.3); 2.0731 (1.0); 2.0576 (1.0); 1.6466 (0.9); 1.6382 (1.2); 1.6252 (1.4); 1.6146 (1.4); 1.6074 (1.2); 1.5938 (1.4); 1.5688 (1.1); 1.5448 (0.8); 1.5361 (0.8); 1.5206 (0.5); 1.5019 (0.6); 1.4868 (0.6); 1.2178 (2.3); 1.2000 (4.2); 1.1916 (4.6); 1.1822 (2.8); 1.1794 (2.6); 1.1738 (8.7); 1.1709 (4.4); 1.1616 (3.9); 1.1561 (4.5); 1.1531 (7.7); 1.1439 (1.9); 1.1353 (3.2); 0.0080 (0.6); -0.0002 (22.4); -0.0085 (0.6) I.1-515: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2755 (0.7); 8.2547 (1.7); 8.2341 (1.2); 7.1741 (2.3); 7.1533 (8.3); 7.1384 (5.8); 7.1340 (4.1); 7.1179 (1.8); 4.6778 (2.0); 4.6398 (2.2); 4.2019 (0.7); 4.1875 (0.8); 4.1641 (0.6); 4.1440 (0.5); 4.0525 (0.8); 4.0175 (1.7); 3.9805 (1.2); 3.7054 (0.7); 3.6946 (0.9); 3.6856 (0.8); 3.3875 (14.2); 3.1680 (1.2); 2.6743 (1.1); 2.6698 (1.5); 2.6651 (1.1); 2.6057 (1.6); 2.5868 (5.1); 2.5682 (4.6); 2.5493 (2.4); 2.5399 (2.2); 2.5296 (1.9); 2.5232 (4.2); 2.5185 (6.0); 2.5099 (90.2); 2.5053 (196.6); 2.5006 (273.5); 2.4960 (191.2); 2.4914 (85.2); 2.3547 (0.8); 2.3322 (1.9); 2.3275 (2.0); 2.2726 (0.6); 2.2597 (0.8); 2.2482 (0.9); 2.2289 (1.0); 2.2182 (0.6); 2.2064 (1.1); 2.1940 (1.0); 2.1864 (1.0); 2.1713 (0.6); 2.1627 (1.0); 2.1516 (0.8); 2.1285 (0.8); 2.0064 (0.7); 1.9974 (0.7); 1.7569 (0.5); 1.7352 (0.6); 1.7248 (0.5); 1.6004 (0.7); 1.5127 (1.3); 1.5007 (2.0); 1.4875 (1.9); 1.4763 (1.4); 1.4652 (1.0); 1.1836 (7.2); 1.1645 (16.0); 1.1457 (6.8); 0.8936 (7.4); 0.8772 (7.2); 0.8287 (6.7); 0.8125 (6.6); 0.0335 (0.6); 0.0080 (4.4); 0.0064 (1.5); 0.0056 (1.8); 0.0048 (2.0); 0.0039 (2.6); -0.0002 (142.0); -0.0059 (1.7); -0.0067 (1.4); -0.0085 (4.0) I.1-516: 1H-NMR (400.0 MHz, d6-DMSO): δ= 12.5667 (0.9); 8.1997 (0.8); 8.1777 (0.8); 8.1480 (1.7); 8.1270 (1.8); 7.2257 (1.9); 7.2206 (2.9); 7.2115 (5.4); 7.2070 (7.8); 7.1952 (1.2); 7.1722 (1.0); 7.1669 (0.9); 7.1534 (2.4); 7.1464 (2.5); 7.1408 (2.3); 7.1364 (4.1); 7.1335 (3.6); 7.1189 (1.8); 7.1008 (0.6); 4.7684 (2.7); 4.7292 (3.0); 4.2250 (0.8); 4.2102 (0.8); 4.2035 (0.8); 4.1888 (0.8); 4.1555 (1.6); 4.1406 (1.7); 4.1347 (1.7); 4.1198 (1.6); 4.0849 (1.0); 4.0611 (2.1); 4.0458 (0.9); 4.0222 (1.9); 3.6785 (0.8); 3.6686 (0.9); 3.6583 (0.9); 3.6481 (1.1); 3.6269 (0.6); 3.3176 (97.6); 2.6744 (0.9); 2.6697 (1.3); 2.6652 (1.0); 2.6253 (1.5); 2.6091 (4.8); 2.6059 (4.6); 2.5900 (4.4); 2.5873 (4.6); 2.5771 (1.8); 2.5681 (2.7); 2.5502 (0.8); 2.5402 (1.2); 2.5233 (4.1); 2.5185 (6.3); 2.5099 (74.0); 2.5053 (158.8); 2.5007 (219.4); 2.4961 (153.2); 2.4915 (68.3); 2.4450 (0.8); 2.4227 (1.0); 2.4004 (1.0); 2.3807 (1.6); 2.3759 (1.7); 2.3540 (1.2); 2.3416 (0.7); 2.3366 (0.7); 2.3321 (1.1); 2.3275 (1.4); 2.3228 (1.2); 2.3191 (1.0); 2.3127 (1.6); 2.2890 (1.7); 2.2784 (1.9); 2.2615 (1.3); 2.2550 (1.9); 2.2452 (0.9); 2.2337 (0.7); 2.2194 (0.7); 2.2099 (0.7); 2.0607 (0.6); 2.0397 (0.9); 2.0063 (1.0); 1.9840 (0.8); 1.8404 (0.5); 1.8308 (0.8); 1.8082 (1.1); 1.7983 (1.2); 1.7901 (0.8); 1.7758 (1.2); 1.7674 (1.3); 1.7571 (1.0); 1.7459 (1.1); 1.7297 (0.8); 1.4077 (0.7); 1.4002 (0.6); 1.3891 (0.9); 1.3849 (0.8); 1.3739 (1.0); 1.3663 (0.8); 1.3553 (0.8); 1.2098 (0.8); 1.1914 (1.1); 1.1690 (1.0); 1.1533 (1.0); 1.1431 (7.2); 1.1401 (5.0); 1.1244 (16.0); 1.1213 (10.0); 1.1055 (6.9); 1.1025 (4.3); 0.8565 (5.3); 0.8468 (12.6); 0.8382 (11.8); 0.8298 (15.0); 0.8196 (4.5); 0.8122 (2.5); 0.0081 (2.4); -0.0002 (82.4); -0.0085 (2.4) I.1-517: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9552 (2.6); 8.5539 (0.9); 8.5332 (0.9); 7.3878 (2.5); 7.1400 (1.9); 7.1201 (4.5); 7.0942 (4.8); 7.0738 (1.9); 4.6568 (0.6); 4.6370 (1.8); 4.6234 (0.6); 4.5996 (1.4); 3.9779 (1.2); 3.9399 (1.3); 3.6394 (16.0); 3.6289 (3.0); 3.3504 (22.2); 3.1613 (0.6); 3.1491 (0.7); 3.1240 (0.9); 3.1111 (0.9); 2.9957 (0.9); 2.9716 (0.8); 2.9584 (0.7); 2.9338 (0.6); 2.6737 (0.6); 2.6691 (0.9); 2.6645 (0.6); 2.5393 (0.5); 2.5335 (0.9); 2.5226 (2.9); 2.5178 (3.3); 2.5092 (49.5); 2.5046 (107.9); 2.5000 (151.2); 2.4954 (104.4); 2.4908 (47.0); 2.3314 (0.8); 2.3268 (1.1); 2.3222 (0.9); 2.3010 (0.8); 2.2736 (11.2); 2.2596 (0.7); 2.2438 (0.6); 2.2297 (0.7); 2.2198 (0.8); 2.2056 (0.8); 2.1635 (1.2); 2.1415 (0.8); 2.1280 (0.7); 2.1065 (0.7); 0.0080 (1.2); - 0.0002 (41.8); -0.0085 (1.2) I.1-518: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3453 (1.8); 8.3245 (1.9); 7.7051 (0.6); 7.2609 (1.0); 7.2576 (1.2); 7.2436 (2.1); 7.2403 (3.0); 7.2363 (3.1); 7.2217 (8.2); 7.2154 (8.0); 7.2029 (3.3); 7.1993 (3.7); 7.1819 (2.2); 7.1730 (0.6); 7.1658 (0.7); 7.1265 (3.6); 7.1069 (6.4); 7.0805 (1.0); 7.0565 (6.5); 7.0364 (3.6); 4.5962 (2.0); 4.5584 (2.1); 4.4474 (0.7); 4.4355 (0.8); 4.4216 (1.1); 4.4148 (1.0); 4.4013 (0.9); 4.3894 (0.7); 3.8739 (2.1); 3.8360 (2.0); 3.5738 (0.7); 3.5632 (1.0); 3.5532 (1.4); 3.5431 (1.0); 3.5314 (0.8); 3.4204 (4.2); 3.1645 (0.7); 3.0876 (1.1); 3.0761 (1.2); 3.0529 (1.5); 3.0418 (1.3); 2.8341 (1.4); 2.8086 (1.5); 2.7994 (1.3); 2.7742 (1.2); 2.6697 (1.0); 2.6650 (0.7); 2.5401 (0.6); 2.5231 (0.9); 2.5185 (2.3); 2.5098 (53.5); 2.5052 (119.7); 2.5006 (168.6); 2.4960 (118.5); 2.4914 (53.6); 2.4791 (3.0); 2.4724 (2.3); 2.4681 (2.8); 2.4451 (1.8); 2.4346 (1.5); 2.3321 (0.7); 2.3275 (1.0); 2.3226 (0.7); 2.2708 (16.0); 2.2529 (1.4); 2.2324 (1.4); 2.2097 (0.9); 2.1844 (0.9); 2.1714 (1.2); 2.1605 (1.3); 2.1473 (1.2); 2.1239 (1.6); 2.1010 (1.6); 2.0899 (1.4); 2.0669 (1.3); 1.8759 (0.6); 1.8641 (0.6); 1.8520 (0.7); 1.8441 (0.9); 1.8200 (0.8); 1.6448 (0.6); 1.6339 (0.9); 1.6243 (0.8); 1.6121 (0.8); 1.6018 (0.7); 0.0080 (1.3); -0.0002 (40.8); -0.0085 (1.1) I.1-519: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.3565 (1.0); 7.3349 (1.0); 7.1982 (0.6); 7.1870 (1.0); 7.1782 (1.0); 7.1702 (0.8); 7.1667 (0.8); 7.1581 (0.6); 7.0990 (0.7); 7.0828 (1.0); 7.0640 (0.8); 7.0508 (0.5); 4.7582 (1.4); 4.7182 (1.6); 4.2737 (1.3); 4.2339 (1.2); 4.1995 (0.7); 4.1596 (0.6); 4.0870 (2.3); 3.9436 (4.0); 3.9370 (3.9); 3.8356 (0.8); 3.8262 (0.9); 3.8157 (0.9); 3.8054 (0.7); 3.3316 (54.4); 2.9487 (16.0); 2.8403 (0.8); 2.8298 (0.8); 2.7997 (1.0); 2.7894 (1.0); 2.7633 (7.3); 2.6755 (0.6); 2.6709 (0.9); 2.6663 (0.6); 2.6555 (0.5); 2.6453 (0.6); 2.5533 (0.9); 2.5409 (0.7); 2.5363 (0.9); 2.5311 (1.4); 2.5243 (2.1); 2.5196 (3.4); 2.5109 (46.9); 2.5064 (99.8); 2.5018 (138.4); 2.4972 (98.6); 2.4927 (45.2); 2.4698 (0.8); 2.4560 (0.8); 2.4515 (0.8); 2.4330 (0.8); 2.4119 (0.7); 2.3994 (0.7); 2.3773 (0.6); 2.3333 (0.8); 2.3286 (1.0); 2.3240 (0.8); 2.2658 (0.7); 2.2542 (0.7); 2.2416 (1.2); 2.2299 (1.1); 2.2002 (1.0); 2.1942 (1.4); 2.1793 (0.9); 2.1676 (0.7); 2.1609 (0.6); 2.1485 (1.0); 2.1244 (0.6); 1.6949 (0.5); 1.6727 (0.6); 1.6556 (0.5); 0.0080 (1.3); -0.0002 (43.1); -0.0085 (1.4) I.1-522: 1H-NMR (400.0 MHz, CDCl3): δ= 7.3270 (0.8); 7.3239 (1.5); 7.3198 (0.6); 7.3111 (0.9); 7.3065 (3.6); 7.3029 (2.0); 7.2913 (1.3); 7.2879 (3.0); 7.2825 (0.6); 7.2666 (0.6); 7.2658 (0.7); 7.2650 (0.9); 7.2603 (62.9); 7.2553 (1.1); 7.2534 (1.8); 7.2497 (1.0); 7.2408 (0.5); 7.2349 (1.7); 7.2166 (0.6); 7.1601 (2.4); 7.1563 (3.4); 7.1510 (0.8); 7.1395 (2.4); 7.1383 (2.3); 7.1364 (1.9); 7.1096 (28.3); 5.2981 (1.1); 5.2743 (0.5); 4.7065 (1.8); 4.6690 (2.0); 4.1086 (1.8); 4.0711 (1.6); 3.9313 (0.7); 3.9209 (0.7); 3.9108 (1.1); 3.9007 (0.7); 3.8901 (0.7); 3.5138 (0.8); 3.4962 (1.3); 3.4810 (1.3); 3.4788 (1.2); 3.4638 (1.2); 3.4615 (1.3); 3.4467 (1.2); 3.4296 (0.8); 2.7830 (2.0); 2.7657 (4.0); 2.7484 (1.8); 2.4840 (1.3); 2.4725 (1.3); 2.4562 (0.9); 2.4480 (1.5); 2.4366 (2.2); 2.4139 (0.7); 2.4052 (0.9); 2.3908 (1.0); 2.3810 (1.2); 2.3668 (1.2); 2.3383 (0.6); 2.3221 (16.0); 2.1924 (0.7); 2.1792 (0.5); 2.1683 (0.6); 2.1600 (0.8); 2.1551 (0.5); 2.1356 (0.7); 2.0491 (1.5); 2.0277 (1.5); 2.0131 (1.3); 1.9916 (1.3); 1.7359 (0.5); 1.7252 (0.6); 1.7155 (0.6); 1.7028 (0.6); 1.6920 (0.5); 1.5819 (0.8); 0.0079 (0.5); -0.0002 (18.4); -0.0085 (0.5) I.1-525: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4851 (2.4); 8.4751 (3.2); 8.0299 (2.2); 7.7108 (1.2); 7.6921 (2.4); 7.6763 (1.5); 7.2369 (3.1); 7.2313 (3.1); 7.2188 (4.7); 7.1385 (2.7); 7.1195 (7.1); 7.0959 (7.0); 7.0770 (3.8); 4.6431 (2.2); 4.6051 (2.4); 3.9711 (2.5); 3.9326 (2.3); 3.9028 (2.2); 3.8912 (1.0); 3.6766 (0.8); 3.6666 (1.4); 3.6557 (1.8); 3.6462 (1.8); 3.6367 (1.4); 3.4924 (0.4); 3.4823 (0.3); 3.3991 (3.4); 3.3851 (4.3); 3.3739 (3.4); 3.3322 (138.2); 3.1656 (0.4); 2.8554 (2.8); 2.8375 (5.6); 2.8205 (3.2); 2.6670 (1.1); 2.5019 (178.1); 2.4981 (194.3); 2.4411 (2.0); 2.4306 (2.5); 2.3519 (0.5); 2.3290 (1.8); 2.3252 (1.9); 2.3123 (1.8); 2.2892 (2.0); 2.2737 (16.0); 2.2438 (1.3); 2.2302 (1.4); 2.2198 (1.7); 2.2031 (1.6); 2.1894 (0.9); 2.1786 (0.8); 2.1643 (0.8); 2.0878 (1.4); 2.0648 (1.6); 2.0533 (2.0); 2.0307 (1.3); 2.0069 (0.5); 1.9842 (0.9); 1.9749 (1.0); 1.9636 (1.2); 1.9533 (1.4); 1.9320 (1.2); 1.9128 (0.5); 1.6508 (0.4); 1.6381 (0.9); 1.6279 (1.2); 1.6157 (1.4); 1.6052 (1.4); 1.5965 (1.3); 1.5844 (1.0); 1.5724 (0.6); 1.3557 (0.4); 1.3355 (0.6); 1.2338 (0.5); 1.2245 (0.8); - 0.0006 (1.8); -0.0110 (0.9) I.1-526: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5085 (0.8); 7.4890 (1.3); 7.4420 (0.9); 7.4230 (1.7); 7.4014 (1.6); 7.3966 (2.1); 7.3565 (1.4); 7.3375 (0.9); 7.2649 (0.6); 7.2615 (37.0); 7.1115 (27.2); 5.3901 (0.6); 4.6910 (1.8); 4.6534 (2.0); 4.1345 (1.8); 4.0969 (1.6); 3.9441 (0.6); 3.9335 (0.7); 3.9234 (1.1); 3.9133 (0.8); 3.9029 (0.7); 3.5347 (0.5); 3.5189 (0.8); 3.5007 (1.3); 3.4853 (1.1); 3.4674 (0.9); 3.4495 (1.0); 3.4347 (1.1); 3.4172 (0.7); 2.8491 (2.0); 2.8314 (3.9); 2.8137 (1.8); 2.5025 (1.3); 2.4912 (1.3); 2.4665 (1.5); 2.4554 (2.0); 2.4371 (0.9); 2.4347 (0.8); 2.4141 (0.8); 2.4104 (1.0); 2.3958 (1.0); 2.3861 (1.1); 2.3719 (1.2); 2.3433 (0.5); 2.3289 (0.6); 2.3185 (16.0); 2.1993 (0.7); 2.1862 (0.5); 2.1753 (0.7); 2.1669 (0.8); 2.1622 (0.5); 2.1426 (0.7); 2.0674 (1.6); 2.0459 (1.6); 2.0313 (1.4); 2.0098 (1.4); 1.7205 (0.6); 1.7110 (0.6); 1.6979 (0.6); 1.6873 (0.5); - 0.0002 (12.3) I.1-527: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5204 (1.4); 7.2615 (276.4); 7.2548 (0.8); 7.2539 (0.6); 7.2531 (0.6); 7.2114 (1.3); 7.2056 (7.2); 7.1997 (3.2); 7.1896 (5.0); 7.1834 (25.2); 7.1786 (4.8); 7.1650 (14.6); 7.1632 (14.4); 7.1427 (5.0); 7.1407 (4.3); 7.1244 (1.1); 7.1129 (2.0); 7.1067 (1.0); 7.0996 (3.9); 7.0910 (1.7); 7.0877 (2.2); 7.0831 (2.8); 7.0811 (2.9); 7.0732 (3.8); 7.0682 (1.4); 7.0618 (2.2); 7.0569 (4.0); 7.0540 (11.1); 7.0492 (7.2); 7.0472 (7.6); 7.0438 (7.0); 7.0398 (12.2); 7.0354 (3.8); 7.0291 (4.6); 7.0202 (0.8); 6.9974 (1.5); 5.4183 (2.3); 5.2994 (2.3); 4.8484 (4.6); 4.8447 (4.5); 4.8097 (5.2); 4.8060 (5.1); 4.2338 (6.7); 4.1951 (6.0); 3.9321 (1.1); 3.9210 (2.2); 3.9102 (2.8); 3.9002 (3.1); 3.8901 (2.8); 3.8792 (2.3); 3.8681 (1.1); 3.5481 (1.0); 3.5319 (2.7); 3.5140 (5.8); 3.5008 (6.6); 3.4993 (6.6); 3.4862 (5.6); 3.4691 (2.8); 3.4520 (0.9); 2.8266 (8.3); 2.8090 (16.0); 2.7915 (7.0); 2.5917 (4.8); 2.5809 (4.7); 2.5556 (5.5); 2.5447 (5.4); 2.5126 (0.9); 2.4942 (1.2); 2.4907 (1.2); 2.4704 (3.4); 2.4512 (3.1); 2.4477 (2.9); 2.4276 (2.9); 2.4178 (3.5); 2.4030 (4.1); 2.3937 (4.8); 2.3791 (4.8); 2.3749 (1.7); 2.3601 (1.4); 2.3507 (2.1); 2.3362 (2.0); 2.2599 (1.8); 2.2408 (2.7); 2.2361 (1.7); 2.2273 (2.2); 2.2218 (1.8); 2.2167 (2.3); 2.2084 (3.0); 2.2032 (2.0); 2.1979 (1.4); 2.1891 (1.9); 2.1838 (2.4); 2.1649 (1.3); 2.1346 (6.0); 2.1123 (5.9); 2.0984 (5.3); 2.0762 (5.2); 1.8064 (1.7); 1.7951 (1.8); 1.7922 (2.1); 1.7809 (2.3); 1.7716 (2.2); 1.7684 (1.9); 1.7623 (1.8); 1.7590 (2.2); 1.7477 (2.0); 1.7387 (1.6); 1.7356 (1.4); 1.7240 (1.3); 1.4557 (1.2); 0.0080 (2.5); -0.0002 (89.4); - 0.0085 (2.5) I.1-528: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5213 (1.0); 7.3828 (3.5); 7.3798 (4.2); 7.3779 (4.6); 7.3750 (4.3); 7.3631 (4.3); 7.3602 (4.9); 7.3582 (5.8); 7.3553 (5.1); 7.3210 (6.9); 7.3170 (11.2); 7.3129 (6.0); 7.2712 (1.0); 7.2696 (1.3); 7.2624 (175.4); 7.2566 (1.0); 7.2558 (0.8); 7.2550 (0.5); 7.2542 (0.5); 7.2001 (6.2); 7.1808 (13.4); 7.1614 (8.0); 7.1231 (1.3); 7.1149 (5.3); 7.1122 (8.6); 7.1110 (7.7); 7.1081 (6.1); 7.0981 (4.8); 7.0960 (4.2); 7.0929 (4.8); 7.0918 (5.0); 7.0891 (4.6); 7.0824 (2.9); 7.0797 (3.2); 7.0719 (4.7); 7.0659 (1.6); 7.0603 (2.0); 7.0557 (4.6); 7.0524 (9.6); 7.0455 (9.3); 7.0422 (7.1); 7.0374 (12.5); 7.0289 (5.3); 7.0267 (4.7); 7.0165 (0.9); 7.0099 (0.8); 6.9983 (1.0); 5.4452 (2.4); 4.8476 (4.9); 4.8439 (4.8); 4.8089 (5.5); 4.8051 (5.4); 4.2337 (7.1); 4.1949 (6.3); 3.9411 (1.2); 3.9300 (2.4); 3.9190 (2.9); 3.9084 (3.2); 3.8990 (2.9); 3.8880 (2.5); 3.8770 (1.2); 3.5608 (0.7); 3.5433 (1.7); 3.5267 (3.2); 3.5093 (5.5); 3.4941 (5.5); 3.4797 (5.3); 3.4770 (3.2); 3.4648 (5.3); 3.4478 (3.2); 3.4308 (1.6); 3.4137 (0.7); 2.7917 (8.3); 2.7744 (16.0); 2.7570 (7.1); 2.5937 (5.1); 2.5828 (5.0); 2.5576 (5.9); 2.5467 (5.7); 2.5197 (1.0); 2.5012 (1.4); 2.4977 (1.2); 2.4780 (3.6); 2.4582 (3.3); 2.4547 (3.0); 2.4349 (3.0); 2.4222 (3.7); 2.4075 (4.4); 2.3981 (5.2); 2.3836 (5.2); 2.3794 (1.8); 2.3647 (1.4); 2.3551 (2.3); 2.3408 (2.3); 2.2730 (1.9); 2.2539 (3.0); 2.2491 (1.8); 2.2404 (2.3); 2.2350 (1.9); 2.2298 (2.4); 2.2214 (3.2); 2.2163 (2.1); 2.2110 (1.4); 2.2023 (2.0); 2.1970 (2.5); 2.1782 (1.3); 2.1259 (6.5); 2.1034 (6.3); 2.0898 (5.6); 2.0673 (5.5); 2.0066 (1.4); 1.8159 (2.0); 1.8045 (2.3); 1.8017 (2.6); 1.7905 (3.1); 1.7810 (3.5); 1.7779 (3.3); 1.7718 (3.4); 1.7687 (3.9); 1.7667 (3.7); 1.7596 (3.3); 1.7574 (3.5); 1.7482 (2.7); 1.7451 (2.4); 1.7336 (2.0); 0.0080 (1.8); 0.0064 (0.6); 0.0056 (0.7); 0.0047 (0.8); 0.0039 (1.1); 0.0023 (2.6); -0.0002 (58.3); -0.0051 (0.7); -0.0059 (0.5); -0.0085 (1.6) I.1-529: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5205 (0.8); 7.3114 (0.6); 7.3010 (8.5); 7.2802 (11.9); 7.2617 (146.4); 7.2117 (0.8); 7.1892 (6.7); 7.1833 (12.8); 7.1773 (10.3); 7.1710 (3.9); 7.1565 (6.0); 7.1502 (4.0); 7.1228 (0.8); 7.1107 (1.7); 7.0979 (3.1); 7.0866 (1.8); 7.0797 (2.6); 7.0737 (3.5); 7.0620 (1.9); 7.0553 (10.4); 7.0488 (6.8); 7.0447 (6.1); 7.0414 (10.1); 7.0367 (2.9); 7.0307 (3.6); 7.0221 (0.8); 6.9977 (0.9); 5.4829 (2.2); 4.8556 (4.1); 4.8522 (4.1); 4.8168 (4.6); 4.8134 (4.6); 4.2473 (6.0); 4.2086 (5.3); 3.9505 (1.0); 3.9395 (1.9); 3.9286 (2.4); 3.9172 (2.6); 3.9083 (2.4); 3.8973 (2.0); 3.8864 (1.0); 3.5808 (0.5); 3.5634 (1.2); 3.5469 (2.7); 3.5294 (4.7); 3.5209 (2.0); 3.5137 (4.5); 3.5039 (4.3); 3.4965 (2.2); 3.4884 (4.5); 3.4713 (2.6); 3.4543 (1.2); 3.4374 (0.5); 2.9322 (8.1); 2.9149 (16.0); 2.8976 (7.0); 2.6153 (4.1); 2.6047 (4.0); 2.5791 (4.7); 2.5685 (4.5); 2.5306 (0.9); 2.5115 (1.2); 2.5077 (1.1); 2.4878 (3.1); 2.4688 (2.8); 2.4645 (2.5); 2.4459 (2.6); 2.4299 (2.8); 2.4153 (3.3); 2.4058 (3.9); 2.3914 (4.0); 2.3872 (1.5); 2.3724 (1.1); 2.3628 (1.8); 2.3485 (1.8); 2.2856 (1.5); 2.2666 (2.4); 2.2618 (1.4); 2.2529 (1.8); 2.2476 (1.4); 2.2425 (1.9); 2.2340 (2.7); 2.2289 (1.6); 2.2237 (1.0); 2.2148 (1.5); 2.2097 (2.0); 2.1908 (1.0); 2.1331 (5.0); 2.1102 (4.9); 2.0970 (4.4); 2.0741 (4.2); 1.8267 (1.4); 1.8127 (1.8); 1.8022 (2.2); 1.7922 (2.1); 1.7795 (2.1); 1.7686 (2.0); 1.7590 (1.7); 1.7561 (1.6); 1.7444 (1.7); 1.7063 (1.9); 0.0079 (1.6); -0.0002 (46.6); -0.0085 (1.2) I.1-535: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2622 (28.4); 7.1141 (19.2); 6.8093 (1.4); 6.7878 (1.9); 6.6949 (0.7); 6.6899 (1.4); 6.6824 (1.7); 6.6777 (1.8); 6.6735 (1.3); 4.7194 (1.1); 4.6819 (1.2); 4.1171 (1.1); 4.0795 (1.0); 3.9428 (0.7); 3.8604 (15.8); 3.8581 (16.0); 3.4772 (0.7); 3.4620 (0.9); 3.4444 (0.9); 3.4297 (0.7); 2.7305 (1.1); 2.7130 (2.3); 2.6954 (1.0); 2.5025 (0.8); 2.4907 (0.8); 2.4858 (0.6); 2.4663 (1.3); 2.4547 (0.8); 2.4361 (0.5); 2.4219 (0.6); 2.4119 (0.7); 2.3979 (0.6); 2.3232 (9.9); 2.0777 (0.9); 2.0565 (0.9); 2.0416 (0.8); 2.0204 (0.8); - 0.0002 (5.0) I.1-536: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2635 (11.5); 7.2470 (0.6); 7.2426 (0.6); 7.2281 (0.8); 7.2267 (0.8); 7.2237 (0.9); 7.2079 (0.7); 7.2035 (0.7); 7.1060 (0.9); 7.1016 (0.9); 7.0873 (1.2); 7.0833 (1.5); 7.0711 (0.5); 7.0583 (1.0); 7.0389 (1.3); 7.0307 (2.0); 7.0286 (1.2); 7.0219 (1.5); 7.0204 (1.5); 7.0155 (0.6); 7.0113 (0.9); 6.9205 (0.8); 6.9178 (0.9); 6.9020 (1.3); 6.8993 (1.6); 6.8829 (1.7); 6.8808 (1.8); 6.8618 (1.2); 4.8305 (0.8); 4.8270 (0.8); 4.7917 (0.9); 4.7882 (0.8); 4.2146 (1.1); 4.1758 (1.0); 3.9003 (0.5); 3.8983 (0.5); 3.8297 (0.8); 3.8251 (16.0); 3.4764 (1.2); 3.4719 (0.9); 3.4629 (1.0); 3.4585 (1.2); 2.8261 (1.4); 2.8094 (2.7); 2.7927 (1.3); 2.5611 (0.8); 2.5500 (0.8); 2.5254 (0.9); 2.5143 (0.9); 2.4612 (0.6); 2.4418 (0.5); 2.4062 (0.6); 2.3916 (0.7); 2.3821 (0.8); 2.3676 (0.8); 2.1896 (0.5); 2.0897 (1.0); 2.0672 (1.0); 2.0540 (0.9); 2.0314 (0.8); - 0.0002 (3.6) I.1-537: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2619 (50.3); 7.0993 (0.6); 7.0723 (0.6); 7.0567 (0.7); 7.0528 (1.5); 7.0459 (1.4); 7.0426 (1.1); 7.0379 (1.9); 7.0294 (0.8); 7.0274 (0.7); 6.8156 (1.4); 6.7940 (2.1); 6.7121 (0.8); 6.7070 (1.5); 6.6996 (1.8); 6.6949 (1.9); 6.6906 (1.3); 4.8496 (0.8); 4.8461 (0.7); 4.8110 (0.8); 4.8073 (0.8); 4.2323 (1.1); 4.1936 (1.0); 3.9200 (0.6); 3.8672 (16.0); 3.8622 (16.0); 3.5004 (1.2); 3.4971 (1.0); 3.4860 (1.0); 3.4825 (1.2); 2.7612 (1.2); 2.7438 (2.5); 2.7264 (1.1); 2.5867 (0.8); 2.5756 (0.8); 2.5506 (0.9); 2.5395 (0.9); 2.4867 (0.6); 2.4668 (0.6); 2.4635 (0.5); 2.4442 (0.5); 2.4332 (0.6); 2.4185 (0.7); 2.4090 (0.8); 2.3946 (0.9); 2.2253 (0.5); 2.1335 (1.0); 2.1114 (0.9); 2.0975 (0.8); 2.0753 (0.8); 0.0079 (0.5); -0.0002 (16.3) I.1-542: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9699 (0.5); 7.0570 (0.6); 7.0536 (0.6); 4.7310 (0.7); 4.6912 (0.8); 4.2321 (0.9); 4.1924 (0.8); 3.7806 (0.5); 3.5759 (16.0); 3.3644 (17.6); 3.0358 (0.7); 3.0263 (0.8); 3.0216 (0.8); 3.0122 (0.7); 2.5108 (7.3); 2.5062 (14.7); 2.5016 (20.6); 2.4970 (14.4); 2.4924 (6.3); 2.4762 (0.8); 2.4646 (0.7); 2.3579 (0.5); 2.3383 (0.5); 2.3050 (1.4); 2.2865 (3.0); 2.2740 (0.6); 2.2676 (1.6); 2.2638 (0.8); 2.2501 (0.6); 2.1890 (0.8); 2.1676 (0.8); 2.1541 (0.7); 2.1325 (0.7); 1.6347 (1.2); 1.6164 (1.7); 1.5984 (1.0); -0.0002 (0.7) I.1-545: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2918 (1.9); 7.2863 (1.1); 7.2749 (1.0); 7.2694 (2.9); 7.2626 (24.2); 7.1681 (7.4); 7.1629 (2.5); 7.1508 (2.3); 7.1445 (1.1); 7.1172 (25.7); 5.4808 (0.6); 5.2982 (7.9); 4.6998 (1.8); 4.6622 (2.0); 4.1443 (1.8); 4.1067 (1.6); 3.9543 (0.6); 3.9436 (0.8); 3.9334 (1.0); 3.9235 (0.8); 3.9128 (0.7); 3.4984 (0.8); 3.4806 (1.4); 3.4650 (1.6); 3.4476 (1.6); 3.4325 (1.2); 3.4153 (0.8); 2.8928 (2.3); 2.8753 (4.6); 2.8579 (2.0); 2.5212 (1.2); 2.5097 (1.5); 2.4850 (2.3); 2.4737 (1.4); 2.4648 (0.9); 2.4621 (0.8); 2.4419 (0.7); 2.4293 (0.8); 2.4151 (1.0); 2.4051 (1.1); 2.3911 (1.1); 2.3623 (0.5); 2.3213 (16.0); 2.2209 (0.7); 2.1968 (0.6); 2.1884 (0.8); 2.1836 (0.5); 2.1640 (0.7); 2.0838 (1.5); 2.0620 (1.5); 2.0476 (1.3); 2.0258 (1.3); 1.7488 (0.6); 1.7390 (0.6); 1.7262 (0.6); 1.7157 (0.5); -0.0002 (8.4) I.1-557: 1H-NMR (400.1 MHz, d6-DMSO): δ= 19.0524 (0.8); 18.7806 (0.8); 18.5751 (0.8); 17.5432 (0.8); 14.8014 (0.8); 10.4423 (0.8); 8.3532 (0.8); 8.3495 (0.8); 8.2886 (4.0); 8.2482 (4.8); 8.2443 (4.5); 8.2005 (0.9); 8.1750 (0.8); 7.3607 (1.9); 7.3373 (3.9); 7.3315 (2.4); 7.3147 (1.9); 7.3076 (1.3); 7.2734 (1.6); 7.2555 (1.8); 7.2498 (3.1); 7.2442 (2.1); 7.2318 (1.2); 7.2262 (2.2); 7.2016 (1.3); 7.1736 (4.7); 7.1569 (9.0); 7.1515 (8.5); 7.1356 (6.5); 7.1177 (1.9); 7.1112 (2.5); 7.1057 (1.5); 7.0934 (2.4); 7.0876 (4.4); 7.0820 (2.4); 7.0729 (1.8); 7.0643 (2.0); 7.0592 (1.4); 7.0000 (1.1); 6.9953 (1.3); 6.9780 (1.7); 6.9719 (3.2); 6.9666 (1.9); 6.9482 (2.2); 6.9205 (4.9); 6.9150 (6.0); 6.8985 (10.1); 6.8820 (5.4); 6.8758 (4.0); 5.7681 (0.8); 4.2471 (1.5); 4.2393 (1.3); 3.9892 (1.9); 3.9811 (1.8); 3.6110 (0.8); 3.5256 (0.9); 3.5089 (1.4); 3.4775 (1.0); 3.4510 (0.9); 3.4449 (0.8); 3.4334 (1.0); 3.4094 (3.8); 3.3730 (3.7); 3.3611 (7.2); 3.3101 (3466.6); 3.2608 (8.4); 3.2382 (2.1); 3.2123 (2.8); 3.1903 (1.0); 3.1687 (6.2); 3.0134 (0.8); 2.9895 (0.9); 2.6963 (1.3); 2.6781 (6.0); 2.6739 (9.7); 2.6691 (12.7); 2.6644 (10.0); 2.6599 (6.4); 2.6508 (1.4); 2.6441 (1.5); 2.5994 (2.0); 2.5954 (2.2); 2.5678 (1.8); 2.5553 (3.6); 2.5505 (4.0); 2.5462 (3.4); 2.5420 (2.1); 2.5226 (18.8); 2.5178 (26.4); 2.5092 (663.4); 2.5046 (1486.8); 2.5001 (2112.1); 2.4955 (1515.8); 2.4909 (706.4); 2.4550 (5.1); 2.4504 (5.3); 2.4458 (4.2); 2.4349 (1.7); 2.4188 (1.4); 2.4161 (1.4); 2.4064 (2.0); 2.3969 (1.3); 2.3570 (0.8); 2.3363 (4.0); 2.3315 (8.6); 2.3269 (12.4); 2.3223 (8.9); 2.3178 (4.3); 2.2569 (0.9); 2.2425 (1.1); 2.2194 (2.3); 2.2059 (1.9); 2.1976 (2.2); 2.1893 (1.7); 2.1785 (2.2); 2.1644 (2.3); 2.1520 (3.7); 2.1351 (3.8); 2.1170 (2.8); 2.0971 (1.4); 2.0712 (5.2); 1.2391 (1.6); 1.2162 (13.6); 1.1991 (13.5); 1.1741 (16.0); 1.1568 (15.6); 0.1460 (1.7); 0.0116 (2.7); 0.0082 (10.6); 0.0000 (384.6) I.1-561: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2620 (36.0); 7.1364 (0.7); 7.1176 (29.3); 7.0989 (1.5); 7.0942 (0.8); 7.0779 (0.7); 6.8360 (0.5); 6.8295 (0.6); 6.8272 (0.7); 6.8152 (0.8); 6.8071 (2.4); 6.7863 (1.5); 6.7842 (1.3); 6.7763 (0.7); 6.7604 (0.9); 6.7540 (0.6); 5.3835 (0.5); 5.2986 (1.5); 4.7020 (1.8); 4.6645 (2.0); 4.1351 (1.8); 4.0975 (1.6); 3.9384 (0.6); 3.9279 (0.8); 3.9177 (1.1); 3.9076 (0.8); 3.8972 (0.7); 3.4539 (0.8); 3.4362 (1.2); 3.4257 (0.6); 3.4207 (1.2); 3.4086 (1.1); 3.4034 (0.6); 3.3933 (1.2); 3.3761 (0.7); 2.7847 (1.4); 2.7673 (2.7); 2.7499 (1.3); 2.4974 (1.5); 2.4860 (1.3); 2.4731 (0.9); 2.4613 (1.5); 2.4499 (2.1); 2.4307 (0.7); 2.4188 (0.8); 2.4046 (1.0); 2.3946 (1.1); 2.3805 (1.1); 2.3518 (0.5); 2.3378 (0.6); 2.3245 (16.0); 2.2054 (0.8); 2.1922 (0.6); 2.1812 (0.7); 2.1728 (0.9); 2.1681 (0.6); 2.1533 (0.5); 2.1485 (0.7); 2.0804 (1.6); 2.0590 (1.6); 2.0442 (1.4); 2.0228 (1.4); 1.7479 (0.6); 1.7379 (0.6); 1.7253 (0.6); 1.7148 (0.5); -0.0002 (10.9) I.1-562: 1H-NMR (400.0 MHz, CDCl3): δ= 7.3829 (0.8); 7.3803 (1.0); 7.3782 (1.0); 7.3756 (0.9); 7.3632 (1.0); 7.3604 (1.1); 7.3584 (1.3); 7.3558 (1.1); 7.3038 (1.5); 7.2997 (2.5); 7.2955 (1.4); 7.2612 (38.6); 7.1921 (1.4); 7.1728 (2.9); 7.1533 (1.7); 7.1151 (28.1); 7.0899 (1.6); 7.0708 (1.0); 5.3541 (0.5); 5.2984 (1.8); 4.7062 (1.5); 4.6687 (1.7); 4.1309 (1.6); 4.0934 (1.5); 3.9385 (0.6); 3.9281 (0.8); 3.9179 (0.6); 3.4928 (0.6); 3.4752 (0.9); 3.4596 (0.8); 3.4428 (0.6); 3.4263 (0.7); 3.4113 (0.8); 3.3941 (0.6); 2.7567 (1.8); 2.7393 (3.4); 2.7220 (1.6); 2.5058 (0.9); 2.4942 (0.8); 2.4871 (0.7); 2.4692 (1.3); 2.4584 (1.0); 2.4441 (0.6); 2.4349 (0.6); 2.4206 (0.6); 2.4107 (0.7); 2.3965 (0.7); 2.3235 (16.0); 2.1805 (0.5); 2.0748 (0.8); 2.0534 (0.8); 2.0387 (0.7); 2.0174 (0.6); -0.0002 (12.7) I.1-565: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2621 (36.5); 7.1409 (0.6); 7.1188 (22.5); 6.2271 (0.6); 4.7750 (1.8); 4.7375 (2.0); 4.0818 (1.8); 4.0444 (1.6); 3.9702 (0.5); 3.9612 (0.8); 3.9511 (0.9); 3.9404 (0.8); 3.3028 (0.6); 3.2857 (1.0); 3.2706 (1.0); 3.2536 (0.6); 3.2473 (1.0); 3.2329 (1.0); 3.2163 (0.6); 2.5482 (1.1); 2.5359 (1.5); 2.5127 (2.1); 2.5004 (1.3); 2.4919 (1.0); 2.4700 (0.6); 2.4308 (0.7); 2.4182 (0.9); 2.4063 (1.0); 2.3936 (1.3); 2.3888 (2.5); 2.3718 (4.4); 2.3636 (1.0); 2.3546 (2.5); 2.3259 (1.8); 2.3190 (16.0); 2.2092 (0.7); 2.1846 (0.8); 2.1805 (1.6); 2.1770 (1.0); 2.1726 (0.6); 2.1598 (1.5); 2.1523 (0.8); 2.1449 (1.2); 2.1242 (1.1); 1.8348 (0.6); 1.8269 (0.7); 1.8177 (2.4); 1.8012 (3.1); 1.7940 (1.2); 1.7840 (2.4); 1.7674 (0.6); 1.4319 (0.6); 1.2216 (1.2); -0.0002 (10.7) I.1-569: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5189 (10.3); 7.3794 (6.3); 7.3746 (6.5); 7.3602 (7.2); 7.3554 (7.5); 7.3335 (1.2); 7.3088 (1.3); 7.2937 (2.1); 7.2898 (2.1); 7.2858 (2.5); 7.2600 (2050.6); 7.2533 (6.5); 7.2524 (5.5); 7.2516 (5.9); 7.2500 (2.9); 7.2492 (2.8); 7.2484 (2.1); 7.2477 (2.0); 7.2453 (1.5); 7.2445 (1.3); 7.2332 (1.5); 7.2317 (1.2); 7.2099 (3.8); 7.1729 (5.4); 7.1538 (14.4); 7.1347 (11.8); 7.1254 (8.6); 7.1206 (9.0); 7.1117 (2.5); 7.1063 (4.4); 7.0990 (3.6); 7.0872 (1.7); 7.0822 (2.4); 7.0746 (3.7); 7.0561 (11.8); 7.0495 (6.4); 7.0458 (6.9); 7.0430 (9.1); 7.0374 (3.0); 7.0317 (3.8); 6.9960 (10.6); 5.4251 (2.2); 4.8537 (3.7); 4.8112 (4.6); 4.2458 (5.6); 4.2078 (5.0); 3.9341 (1.8); 3.9228 (2.3); 3.9130 (2.5); 3.9032 (2.4); 3.8918 (1.9); 3.5566 (2.3); 3.5485 (2.0); 3.5387 (5.1); 3.5315 (4.9); 3.5236 (4.9); 3.5160 (5.1); 3.5059 (2.3); 3.4991 (2.5); 3.0103 (7.7); 2.9929 (16.0); 2.9755 (7.2); 2.6007 (3.8); 2.5901 (4.0); 2.5646 (4.6); 2.5537 (4.4); 2.5118 (1.2); 2.4887 (3.1); 2.4699 (2.5); 2.4454 (2.5); 2.4286 (2.9); 2.4141 (3.4); 2.4045 (4.0); 2.3901 (4.0); 2.3707 (1.2); 2.3616 (1.9); 2.3473 (2.1); 2.2673 (1.6); 2.2480 (2.3); 2.2346 (1.7); 2.2241 (1.9); 2.2153 (2.3); 2.2106 (1.7); 2.1967 (1.9); 2.1908 (2.0); 2.1720 (1.2); 2.1325 (5.0); 2.1099 (4.9); 2.0963 (4.3); 2.0737 (4.3); 1.8045 (1.8); 1.7949 (1.9); 1.7844 (2.0); 1.7692 (2.0); 1.7600 (1.9); 1.7505 (1.5); 1.5999 (9.2); 1.4632 (1.9); 0.1458 (2.2); 0.0110 (2.5); 0.0079 (19.2); 0.0062 (6.6); 0.0054 (7.6); 0.0046 (9.0); 0.0037 (12.3); - 0.0002 (674.6); -0.0028 (35.2); -0.0044 (13.0); -0.0052 (7.7); -0.0061 (5.8); -0.0069 (5.0); -0.0085 (19.7); -0.0108 (2.6); -0.0117 (2.2); -0.0124 (2.1); -0.0132 (1.4); -0.0141 (1.3); -0.0148 (1.6); -0.0172 (1.1); - 0.0196 (1.1); -0.0504 (1.7); -0.1495 (1.7) I.1-570: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5194 (0.5); 7.2606 (101.1); 7.1825 (0.8); 7.1751 (0.6); 7.1672 (0.8); 7.1599 (8.6); 7.1547 (5.8); 7.1377 (0.6); 7.1300 (0.8); 7.1163 (28.1); 6.9965 (0.5); 5.2827 (0.6); 4.7029 (1.8); 4.6654 (2.0); 4.1391 (1.8); 4.1016 (1.6); 3.9416 (0.6); 3.9316 (0.7); 3.9211 (1.1); 3.9105 (0.7); 3.9006 (0.7); 3.4977 (0.8); 3.4794 (1.3); 3.4641 (1.1); 3.4585 (0.6); 3.4462 (0.7); 3.4407 (1.1); 3.4259 (1.2); 3.4086 (0.7); 2.7889 (2.3); 2.7712 (4.6); 2.7536 (2.0); 2.4969 (1.3); 2.4855 (1.3); 2.4688 (0.9); 2.4608 (1.5); 2.4493 (2.2); 2.4264 (0.8); 2.4210 (0.9); 2.4066 (1.0); 2.3968 (1.2); 2.3825 (1.1); 2.3397 (0.5); 2.3237 (16.0); 2.1983 (0.7); 2.1851 (0.5); 2.1742 (0.7); 2.1657 (0.8); 2.1610 (0.6); 2.1415 (0.7); 2.0759 (1.6); 2.0547 (1.5); 2.0398 (1.4); 2.0186 (1.4); 1.7357 (0.5); 1.7252 (0.6); 1.7153 (0.6); 1.7025 (0.6); 1.6919 (0.5); 0.0080 (1.0); -0.0002 (34.0); -0.0085 (0.9) I.1-572: 1H-NMR (400.0 MHz, CDCl3): δ= 7.7562 (2.0); 7.6093 (4.5); 7.2618 (40.2); 7.1161 (25.1); 4.6782 (1.7); 4.6406 (2.0); 4.1609 (1.5); 4.1233 (1.3); 3.9619 (0.6); 3.9514 (0.7); 3.9412 (1.0); 3.9311 (0.7); 3.9206 (0.6); 3.5227 (0.8); 3.5042 (1.1); 3.4887 (1.0); 3.4705 (0.8); 3.4521 (0.9); 3.4370 (1.0); 3.4191 (0.7); 2.9325 (1.8); 2.9146 (3.7); 2.8967 (1.6); 2.5189 (1.2); 2.5075 (1.2); 2.4827 (1.6); 2.4713 (1.4); 2.4618 (0.8); 2.4402 (0.8); 2.4197 (1.2); 2.4055 (0.8); 2.3959 (0.9); 2.3816 (0.9); 2.3174 (16.0); 2.2195 (0.6); 2.1957 (0.6); 2.1871 (0.7); 2.1630 (0.6); 2.0839 (1.5); 2.0625 (1.4); 2.0477 (1.3); 2.0262 (1.3); 1.7243 (0.5); 1.7150 (0.5); 1.7012 (0.5); -0.0002 (8.8) I.1-573: 1H-NMR (400.0 MHz, CDCl3): δ= 7.7604 (6.9); 7.6337 (16.0); 7.5227 (0.6); 7.2637 (122.0); 7.2603 (2.2); 7.2595 (1.6); 7.2586 (1.3); 7.2578 (1.0); 7.2570 (0.8); 7.2562 (0.7); 7.2554 (0.6); 7.2546 (0.5); 7.1244 (0.9); 7.1151 (1.3); 7.1086 (1.3); 7.0998 (3.1); 7.0873 (2.4); 7.0849 (2.2); 7.0810 (2.5); 7.0748 (5.1); 7.0665 (1.6); 7.0647 (1.6); 7.0630 (1.8); 7.0560 (7.6); 7.0480 (9.9); 7.0452 (6.2); 7.0392 (8.2); 7.0322 (3.1); 7.0286 (4.3); 7.0174 (0.8); 7.0109 (0.5); 6.9996 (0.6); 5.6265 (1.9); 4.8452 (4.1); 4.8416 (4.0); 4.8065 (4.6); 4.8029 (4.5); 4.2410 (5.8); 4.2023 (5.2); 3.9567 (0.9); 3.9456 (1.9); 3.9347 (2.4); 3.9240 (2.7); 3.9146 (2.5); 3.9037 (2.0); 3.8927 (1.0); 3.6128 (0.6); 3.5949 (1.6); 3.5790 (2.7); 3.5607 (4.2); 3.5452 (3.6); 3.5313 (1.7); 3.5272 (1.9); 3.5133 (3.0); 3.4980 (3.6); 3.4808 (2.6); 3.4637 (1.3); 3.4466 (0.7); 2.9777 (4.6); 2.9583 (7.7); 2.9435 (3.5); 2.9401 (3.6); 2.6155 (4.2); 2.6046 (4.2); 2.5792 (4.8); 2.5684 (4.7); 2.5128 (0.8); 2.4935 (1.0); 2.4900 (1.0); 2.4699 (3.0); 2.4504 (2.8); 2.4469 (2.7); 2.4274 (2.8); 2.4222 (3.1); 2.4074 (3.4); 2.3981 (4.1); 2.3836 (4.1); 2.3793 (1.4); 2.3645 (1.0); 2.3551 (1.8); 2.3408 (1.7); 2.2809 (1.6); 2.2618 (2.6); 2.2573 (1.6); 2.2484 (2.0); 2.2428 (1.6); 2.2379 (2.2); 2.2294 (2.9); 2.2244 (1.8); 2.2190 (1.2); 2.2102 (1.7); 2.2051 (2.3); 2.1862 (1.2); 2.1495 (5.4); 2.1270 (5.3); 2.1132 (4.7); 2.0908 (4.6); 1.8044 (1.3); 1.7931 (1.5); 1.7903 (1.7); 1.7793 (1.9); 1.7699 (1.9); 1.7666 (1.6); 1.7604 (1.5); 1.7572 (1.9); 1.7461 (1.7); 1.7370 (1.3); 1.7339 (1.2); 1.7224 (1.1); 0.0080 (1.1); 0.0023 (1.5); -0.0002 (38.7); - 0.0050 (0.7); -0.0059 (0.6); -0.0067 (0.5); -0.0085 (1.2) I.1-594: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3935 (2.8); 8.3733 (3.0); 7.2803 (1.2); 7.2622 (3.4); 7.2500 (1.5); 7.2446 (4.4); 7.2262 (8.3); 7.2177 (15.8); 7.2091 (3.4); 7.1851 (2.7); 7.1581 (5.3); 7.1379 (9.8); 7.1042 (5.7); 7.0837 (7.2); 7.0634 (2.7); 4.6179 (1.8); 4.5803 (2.0); 4.4744 (0.8); 4.4607 (1.0); 4.4490 (1.0); 4.4208 (0.9); 3.9881 (1.9); 3.9499 (1.6); 3.8788 (1.7); 3.8411 (1.5); 3.6314 (9.1); 3.5654 (2.4); 3.1661 (2.4); 3.0799 (1.2); 3.0557 (1.5); 3.0465 (1.4); 2.8363 (1.8); 2.8101 (2.0); 2.8017 (1.5); 2.7767 (1.4); 2.6760 (1.4); 2.6713 (1.9); 2.6667 (1.3); 2.5983 (1.3); 2.5780 (3.8); 2.5589 (4.0); 2.5392 (1.7); 2.5248 (6.7); 2.5201 (9.1); 2.5114 (116.1); 2.5068 (251.5); 2.5022 (347.2); 2.4976 (240.9); 2.4931 (107.4); 2.4721 (1.7); 2.4611 (3.1); 2.3336 (1.4); 2.3291 (2.0); 2.3243 (1.5); 2.2986 (0.7); 2.2795 (0.8); 2.2578 (1.5); 2.2374 (1.8); 2.2140 (1.0); 2.1844 (1.3); 2.1714 (1.6); 2.1606 (1.7); 2.1472 (1.9); 2.1293 (0.9); 2.1159 (2.7); 2.1049 (1.8); 2.0935 (1.2); 2.0815 (1.8); 2.0748 (1.1); 2.0589 (1.0); 1.8439 (0.7); 1.8198 (0.6); 1.7689 (0.7); 1.7364 (0.8); 1.7125 (0.7); 1.6465 (0.7); 1.6367 (0.8); 1.3732 (1.0); 1.3552 (1.2); 1.3321 (0.6); 1.2368 (1.5); 1.1794 (6.8); 1.1761 (7.3); 1.1605 (14.4); 1.1571 (16.0); 1.1414 (6.5); 1.1381 (6.8); -0.0002 (6.9) I.2-1: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5740 (0.6); 8.5594 (1.2); 8.5448 (0.6); 7.3984 (0.5); 7.3921 (5.0); 7.3870 (1.7); 7.3759 (2.0); 7.3707 (7.3); 7.3645 (0.9); 7.2835 (0.8); 7.2774 (5.5); 7.2721 (1.6); 7.2609 (1.4); 7.2558 (3.8); 4.2738 (3.2); 4.2589 (3.1); 3.5265 (1.3); 3.5043 (2.2); 3.5025 (2.3); 3.4804 (2.0); 3.4091 (4.6); 3.3804 (2.1); 3.3655 (2.1); 3.3563 (1.4); 3.3414 (1.5); 3.1637 (0.6); 3.1600 (0.8); 3.1488 (0.6); 3.1446 (0.8); 3.1417 (0.9); 3.1378 (0.6); 3.1264 (0.8); 3.0189 (0.7); 2.9995 (0.8); 2.9857 (1.9); 2.9662 (1.9); 2.9467 (1.8); 2.9286 (1.8); 2.9134 (0.7); 2.8953 (0.7); 2.5236 (0.6); 2.5189 (0.8); 2.5103 (11.6); 2.5057 (25.6); 2.5011 (36.1); 2.4964 (24.8); 2.4919 (11.0); 2.4796 (0.6); 2.4608 (2.4); 2.4393 (3.5); 2.4217 (2.3); 2.3987 (0.6); 1.8499 (0.8); 1.8329 (1.0); 1.8158 (0.8); 0.8216 (10.5); 0.8057 (16.0); 0.7898 (10.2); -0.0002 (8.2) I.2-11: 1H-NMR (400.0 MHz, CDCl3): δ= 8.5586 (1.3); 8.5561 (1.5); 8.5543 (1.5); 8.5519 (1.3); 8.5462 (1.3); 8.5438 (1.6); 8.5420 (1.5); 8.5396 (1.3); 7.7246 (1.3); 7.7201 (1.3); 7.7054 (2.4); 7.7010 (2.4); 7.6862 (1.6); 7.6818 (1.5); 7.5194 (1.0); 7.4757 (0.6); 7.4692 (5.2); 7.4644 (1.7); 7.4529 (1.8); 7.4479 (6.1); 7.4415 (0.6); 7.2857 (2.3); 7.2742 (0.5); 7.2726 (0.7); 7.2661 (3.9); 7.2654 (4.0); 7.2645 (4.6); 7.2606 (162.9); 7.2564 (2.2); 7.2556 (1.5); 7.2547 (1.0); 7.2540 (0.8); 7.2531 (0.7); 7.2523 (0.7); 7.2515 (0.7); 7.2499 (1.0); 7.2485 (1.3); 7.2475 (1.3); 7.2460 (1.3); 7.2443 (1.1); 7.2421 (1.3); 7.2405 (1.1); 7.2396 (1.1); 7.2299 (1.1); 7.2270 (1.1); 7.2105 (1.4); 7.1814 (4.0); 7.1799 (4.4); 7.1595 (3.9); 7.1579 (3.4); 7.1064 (0.8); 6.9965 (0.9); 4.6177 (5.4); 4.6060 (5.3); 4.1966 (2.2); 4.1773 (2.4); 4.1724 (2.7); 4.1531 (2.9); 3.9960 (2.7); 3.9744 (3.2); 3.9718 (2.6); 3.9501 (2.2); 3.3318 (1.2); 3.3099 (1.4); 3.2895 (1.2); 3.2672 (0.5); 3.0280 (2.1); 3.0056 (1.7); 2.9857 (3.2); 2.9633 (3.0); 2.8681 (3.3); 2.8445 (3.0); 2.8257 (2.0); 2.8021 (1.9); 2.3262 (16.0); 1.6273 (3.2); 0.0080 (1.8); -0.0002 (70.3); -0.0085 (2.0) I.2-12: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4468 (0.5); 7.1785 (1.9); 7.1732 (0.6); 7.1620 (0.7); 7.1566 (2.3); 6.8903 (2.8); 6.8850 (0.8); 6.8738 (0.7); 6.8685 (2.4); 4.2122 (1.4); 4.1976 (1.3); 3.7255 (16.0); 3.5129 (0.6); 3.4906 (0.9); 3.4890 (1.0); 3.4669 (0.8); 3.3730 (0.8); 3.3579 (0.8); 3.3490 (0.6); 3.3339 (0.6); 2.9843 (0.8); 2.9649 (0.8); 2.9462 (0.8); 2.9281 (0.8); 2.5100 (3.8); 2.5054 (8.3); 2.5008 (11.6); 2.4962 (8.1); 2.4916 (3.6); 2.4447 (1.1); 2.4327 (1.1); 2.4222 (1.0); 2.4137 (1.1); 0.8219 (4.6); 0.8107 (4.8); 0.8053 (4.7); 0.7941 (4.5); -0.0002 (1.3) I.2-14: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5422 (0.9); 8.5280 (1.7); 8.5136 (0.9); 7.3424 (2.1); 7.3385 (1.1); 7.3298 (1.4); 7.3236 (4.5); 7.3215 (3.9); 7.3152 (1.0); 7.3058 (5.5); 7.2543 (7.0); 7.2464 (2.5); 7.2397 (4.5); 7.2348 (3.9); 7.2264 (1.1); 7.2228 (1.0); 4.2935 (3.8); 4.2902 (3.8); 4.2788 (3.8); 4.2756 (3.7); 3.8969 (0.9); 3.5315 (1.8); 3.5077 (3.4); 3.4855 (2.7); 3.3921 (2.4); 3.3771 (2.8); 3.3680 (1.8); 3.3530 (2.0); 3.1902 (0.5); 3.1750 (0.7); 3.1709 (1.0); 3.1683 (1.2); 3.1559 (1.0); 3.1528 (1.3); 3.1492 (1.5); 3.1340 (1.2); 3.1270 (0.7); 3.0232 (1.1); 3.0038 (1.1); 2.9900 (2.7); 2.9705 (2.8); 2.9502 (2.6); 2.9322 (2.7); 2.9170 (1.1); 2.8989 (1.1); 2.5231 (0.5); 2.5096 (11.2); 2.5052 (23.7); 2.5006 (31.7); 2.4961 (22.6); 2.4916 (10.5); 2.4626 (3.6); 2.4496 (4.0); 2.4402 (3.7); 2.4306 (3.6); 2.4081 (0.6); 1.8737 (0.6); 1.8561 (1.2); 1.8389 (1.6); 1.8218 (1.2); 1.8042 (0.7); 0.8246 (14.1); 0.8122 (16.0); 0.8080 (15.4); 0.7956 (13.8); -0.0002 (4.2) I.2-16: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5398 (0.9); 7.4562 (0.9); 7.4532 (1.7); 7.4496 (0.8); 7.4381 (1.3); 7.4358 (2.2); 7.4322 (1.3); 7.3400 (0.9); 7.3361 (2.3); 7.3339 (1.4); 7.3266 (5.8); 7.3232 (4.7); 7.3187 (2.6); 7.3081 (0.9); 7.3056 (0.5); 7.3007 (1.2); 7.2898 (1.0); 4.3623 (2.1); 4.3566 (2.0); 4.3479 (2.1); 4.3423 (2.1); 3.5477 (1.0); 3.5256 (1.7); 3.5238 (1.8); 3.5017 (1.6); 3.4045 (1.4); 3.3896 (1.7); 3.3803 (1.4); 3.3657 (7.2); 3.2169 (0.5); 3.2131 (0.6); 3.1979 (0.6); 3.1949 (0.8); 3.1797 (0.6); 3.0248 (0.6); 3.0054 (0.6); 2.9915 (1.5); 2.9721 (1.5); 2.9518 (1.4); 2.9338 (1.4); 2.9186 (0.6); 2.9005 (0.6); 2.5190 (0.8); 2.5101 (7.9); 2.5055 (17.6); 2.5009 (24.7); 2.4963 (17.4); 2.4917 (7.6); 2.4782 (1.9); 2.4588 (2.3); 2.4557 (2.2); 2.4406 (1.9); 1.8576 (0.6); 1.8406 (0.8); 1.8235 (0.6); 0.8252 (8.4); 0.8088 (16.0); 0.7924 (8.2); -0.0002 (6.1) I.2-17: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5855 (0.8); 8.5712 (1.5); 8.5569 (0.8); 7.6134 (4.8); 7.6081 (4.9); 7.4380 (2.2); 7.4327 (2.0); 7.4172 (3.5); 7.4119 (3.4); 7.3515 (4.3); 7.3306 (2.6); 4.3318 (2.7); 4.3272 (2.7); 4.3175 (2.7); 4.3129 (2.7); 3.9308 (0.6); 3.5405 (1.5); 3.5183 (2.4); 3.5165 (2.6); 3.4944 (2.2); 3.3917 (2.0); 3.3769 (2.2); 3.3675 (1.4); 3.3528 (1.7); 3.2104 (0.5); 3.2070 (0.7); 3.2029 (0.8); 3.1923 (0.7); 3.1874 (0.9); 3.1851 (1.1); 3.1806 (0.6); 3.1698 (0.8); 3.1656 (0.5); 3.1623 (0.5); 3.0208 (0.8); 3.0014 (0.9); 2.9876 (2.1); 2.9681 (2.2); 2.9479 (2.0); 2.9298 (2.1); 2.9147 (0.8); 2.8965 (0.8); 2.5198 (0.6); 2.5112 (8.4); 2.5066 (18.5); 2.5020 (25.9); 2.4974 (18.0); 2.4928 (8.4); 2.4748 (2.5); 2.4505 (3.9); 2.4313 (2.5); 2.4080 (0.7); 2.3898 (0.6); 1.8512 (0.9); 1.8341 (1.2); 1.8170 (0.9); 0.8223 (11.9); 0.8041 (16.0); 0.7871 (11.6); -0.0002 (6.3) I.2-21: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6901 (1.2); 8.6752 (2.2); 7.6547 (6.9); 7.6518 (7.8); 7.6467 (2.6); 7.6351 (4.3); 7.6326 (8.6); 7.6300 (6.8); 7.6243 (0.6); 7.5139 (1.5); 7.5101 (4.4); 7.5071 (3.8); 7.4908 (4.3); 7.4879 (6.5); 7.4841 (1.6); 7.4577 (0.6); 7.4439 (0.9); 7.4364 (1.0); 7.4230 (1.4); 7.4028 (16.0); 7.3932 (6.2); 7.3879 (2.0); 7.3835 (4.3); 7.3748 (7.7); 7.3718 (5.4); 7.3577 (2.2); 7.3530 (6.1); 7.1582 (1.7); 7.1554 (3.3); 7.1527 (1.8); 7.1371 (4.8); 7.1213 (1.3); 7.1185 (2.1); 7.1157 (1.0); 5.7549 (1.1); 4.3761 (7.1); 4.3618 (6.9); 4.0686 (2.6); 4.0471 (3.7); 4.0442 (4.3); 4.0228 (3.6); 3.9297 (3.5); 3.9149 (3.6); 3.9054 (2.6); 3.8906 (2.7); 3.8090 (1.3); 3.3719 (3.4); 3.3211 (379.4); 3.2709 (4.2); 3.2207 (0.8); 2.8176 (2.5); 2.7942 (2.4); 2.7753 (4.7); 2.7520 (4.1); 2.6957 (4.4); 2.6782 (5.0); 2.6748 (2.8); 2.6700 (3.4); 2.6655 (2.2); 2.6536 (2.3); 2.6359 (2.2); 2.5509 (1.9); 2.5463 (1.5); 2.5235 (9.6); 2.5189 (13.6); 2.5102 (177.2); 2.5056 (387.1); 2.5010 (542.7); 2.4963 (376.1); 2.4917 (164.1); 2.4601 (2.5); 2.4555 (4.2); 2.4509 (5.4); 2.4462 (4.0); 2.4417 (2.3); 2.3324 (2.6); 2.3277 (3.4); 2.3230 (2.6); 2.0731 (1.6); 1.4820 (1.2); 0.9264 (1.2); -0.0002 (11.5) I.2-22: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5203 (6.5); 7.4249 (5.5); 7.4043 (6.1); 7.3636 (4.9); 7.3575 (4.4); 7.3204 (2.0); 7.3107 (6.9); 7.3080 (7.3); 7.2949 (4.9); 7.2878 (4.5); 7.2615 (903.3); 7.2589 (209.3); 7.2517 (6.1); 7.2476 (3.2); 7.2468 (3.2); 7.2397 (2.0); 7.2365 (1.9); 7.2341 (1.3); 7.2112 (10.3); 7.1985 (1.0); 7.1621 (2.2); 7.1291 (2.2); 7.1238 (2.3); 7.1085 (1.8); 7.1034 (1.9); 6.9974 (5.0); 5.8413 (1.0); 4.4815 (0.8); 4.4663 (0.8); 4.4435 (2.4); 4.4284 (2.4); 4.4117 (2.4); 4.3971 (2.2); 4.3749 (0.8); 4.3597 (0.7); 3.7088 (1.8); 3.6916 (1.9); 3.6842 (2.2); 3.6673 (2.3); 3.5374 (2.2); 3.5157 (2.7); 3.5129 (2.6); 3.4914 (2.0); 3.1684 (0.9); 3.1494 (1.2); 3.1352 (2.1); 3.1152 (2.2); 3.0862 (2.6); 3.0676 (2.4); 3.0344 (1.3); 3.0201 (0.6); 2.7594 (0.9); 2.7388 (0.8); 2.7168 (2.5); 2.6967 (2.3); 2.6775 (2.4); 2.6534 (2.2); 2.6355 (0.8); 2.6119 (0.7); 2.0090 (0.9); 1.9492 (1.1); 1.9310 (1.7); 1.9131 (2.0); 1.8960 (1.7); 1.8790 (1.4); 1.6751 (1.4); 1.6184 (1.6); 1.6069 (4.4); 1.5604 (274.2); 1.5101 (4.0); 0.9150 (13.8); 0.9117 (16.0); 0.8983 (13.5); 0.8950 (15.2); 0.1464 (1.3); 0.0753 (0.6); 0.0466 (2.1); 0.0079 (10.7); -0.0002 (249.5); -0.0029 (57.5); -0.0085 (8.1); -0.0505 (2.6); -0.1496 (0.8) I.2-26: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5315 (4.1); 8.5239 (4.3); 8.5115 (4.4); 8.5032 (4.1); 8.2049 (11.4); 7.8558 (5.2); 7.8354 (6.2); 7.6521 (3.2); 7.6486 (3.2); 7.6319 (6.2); 7.6281 (6.3); 7.6124 (3.4); 7.5058 (7.9); 7.4865 (6.0); 7.4215 (0.7); 7.2692 (4.4); 7.2503 (13.0); 7.2341 (9.9); 7.2248 (15.6); 7.2223 (16.0); 7.2174 (14.2); 7.2119 (11.2); 7.2048 (6.2); 7.1998 (6.7); 7.1952 (6.0); 7.1818 (3.7); 7.1645 (1.2); 5.3366 (2.6); 5.3173 (7.5); 5.2976 (7.6); 5.2777 (2.5); 4.4095 (0.6); 4.1318 (3.0); 4.1077 (5.9); 4.1022 (3.4); 4.0861 (5.0); 4.0805 (5.1); 4.0779 (5.8); 4.0564 (4.6); 4.0299 (4.8); 4.0149 (5.1); 4.0055 (4.0); 4.0018 (5.4); 3.9905 (4.2); 3.9869 (5.5); 3.9774 (3.2); 3.9625 (3.2); 3.3290 (47.4); 3.2960 (13.3); 3.2788 (7.9); 3.2568 (3.7); 2.9805 (2.0); 2.9725 (2.3); 2.9584 (2.4); 2.9501 (2.5); 2.9411 (3.9); 2.9326 (4.2); 2.9189 (4.2); 2.9105 (3.9); 2.8628 (2.8); 2.8556 (3.2); 2.8349 (6.8); 2.8202 (8.2); 2.8147 (5.9); 2.8075 (3.0); 2.7972 (9.8); 2.7870 (12.5); 2.7681 (8.1); 2.7650 (7.7); 2.7553 (7.5); 2.7438 (3.0); 2.7372 (6.8); 2.7257 (2.3); 2.7128 (2.3); 2.6947 (2.1); 2.6740 (2.8); 2.6695 (3.8); 2.6649 (2.7); 2.6602 (1.3); 2.5943 (0.6); 2.5499 (2.0); 2.5316 (2.7); 2.5229 (11.4); 2.5182 (16.0); 2.5095 (203.3); 2.5050 (439.3); 2.5004 (611.4); 2.4958 (431.3); 2.4912 (195.0); 2.4757 (1.8); 2.4710 (1.1); 2.4563 (1.0); 2.4479 (1.6); 2.4366 (2.7); 2.4292 (3.5); 2.4212 (2.8); 2.4171 (3.5); 2.4092 (3.3); 2.4053 (3.1); 2.3981 (3.9); 2.3897 (2.5); 2.3783 (1.9); 2.3700 (1.2); 2.3365 (1.2); 2.3317 (2.6); 2.3272 (3.6); 2.3225 (2.5); 2.0721 (1.1); 1.8555 (1.3); 1.8493 (1.3); 1.8340 (3.0); 1.8275 (3.2); 1.8142 (3.2); 1.8075 (3.4); 1.7960 (3.1); 1.7828 (3.0); 1.7760 (2.9); 1.7611 (1.2); 1.7540 (1.4); 1.2457 (0.7); 0.9327 (0.9); 0.9145 (1.9); 0.8958 (1.0); 0.8583 (1.1); 0.0080 (4.0); -0.0002 (137.7); -0.0086 (4.0) I.2-31: 1H-NMR (400.0 MHz, CDCl3): δ= 8.3132 (7.0); 8.3004 (7.1); 8.1306 (16.0); 7.6652 (6.9); 7.5197 (0.8); 7.2713 (0.9); 7.2697 (1.1); 7.2690 (1.2); 7.2607 (149.2); 7.1730 (0.8); 7.1487 (4.3); 7.1454 (4.5); 7.1359 (4.2); 7.1326 (4.3); 6.9967 (0.8); 6.9093 (8.2); 6.9078 (8.1); 6.8382 (0.8); 6.1246 (1.9); 5.2987 (4.2); 4.5985 (0.5); 4.5833 (0.6); 4.5589 (5.9); 4.5515 (6.0); 4.5437 (5.9); 4.5362 (5.9); 4.5119 (0.6); 4.4965 (0.6); 4.2887 (4.1); 4.2710 (4.4); 4.2649 (5.2); 4.2472 (5.2); 4.0882 (4.8); 4.0668 (6.0); 4.0645 (5.1); 4.0430 (4.0); 3.3264 (0.9); 3.3053 (2.2); 3.2877 (2.3); 3.2847 (2.8); 3.2816 (2.7); 3.2640 (2.5); 3.2608 (1.6); 3.2429 (1.1); 3.0354 (2.8); 3.0146 (2.3); 2.9925 (7.5); 2.9837 (0.9); 2.9717 (6.9); 2.9629 (0.9); 2.9537 (7.6); 2.9299 (6.7); 2.9108 (2.7); 2.8870 (2.3); 1.5612 (5.6); 1.3227 (1.1); 1.2746 (1.5); 1.2561 (0.8); 0.0080 (1.6); -0.0002 (55.6); - 0.0085 (1.6) I.2-34: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4829 (2.2); 7.7137 (3.4); 7.7074 (4.6); 7.7011 (4.6); 7.6952 (5.8); 7.6902 (5.7); 7.6843 (5.4); 7.6778 (5.2); 7.6719 (4.6); 7.2432 (6.3); 7.2378 (7.7); 7.2314 (5.1); 7.2157 (16.0); 7.1986 (7.4); 7.1938 (6.4); 5.3158 (3.9); 5.2949 (3.4); 4.0287 (2.6); 4.0067 (2.4); 3.9981 (3.0); 3.9763 (2.8); 3.9553 (2.2); 3.9401 (2.4); 3.9304 (3.5); 3.9158 (3.8); 3.3156 (95.1); 3.2682 (3.3); 3.2491 (2.6); 2.9287 (2.2); 2.9160 (2.2); 2.9064 (2.0); 2.8330 (3.4); 2.8113 (2.4); 2.7927 (2.4); 2.7638 (4.1); 2.7406 (5.1); 2.7289 (3.4); 2.7205 (3.9); 2.7130 (3.4); 2.7067 (3.3); 2.6940 (3.4); 2.6697 (3.1); 2.5227 (9.0); 2.5093 (174.6); 2.5048 (377.9); 2.5002 (523.1); 2.4956 (367.1); 2.4910 (163.6); 2.4258 (2.3); 2.3271 (2.8); 1.8242 (2.2); 1.7921 (2.1); 0.0079 (3.2); -0.0002 (99.6); -0.0087 (2.6) I.2-35: 1H-NMR (400.0 MHz, CDCl3): δ= 7.4142 (0.7); 7.3996 (0.7); 7.3932 (0.5); 7.3784 (0.5); 7.2749 (1.8); 7.2719 (2.3); 7.2593 (88.1); 7.2423 (1.8); 7.2317 (0.9); 7.2200 (0.6); 6.9406 (0.5); 6.9353 (0.6); 6.9290 (0.8); 6.9232 (0.9); 6.9212 (1.0); 6.9141 (0.6); 6.9084 (1.3); 6.9020 (0.9); 6.8874 (0.6); 5.5358 (0.7); 5.5165 (0.7); 4.1157 (0.6); 4.0976 (0.6); 4.0918 (0.8); 4.0740 (0.8); 3.9712 (0.9); 3.9495 (1.1); 3.9260 (0.7); 3.2268 (0.6); 2.9800 (0.9); 2.9593 (0.7); 2.9375 (1.3); 2.9292 (0.8); 2.9169 (1.1); 2.9093 (0.6); 2.7970 (1.2); 2.7735 (1.1); 2.7545 (0.8); 2.7310 (0.7); 1.5383 (16.0); 0.0080 (1.0); -0.0002 (32.1); -0.0085 (1.0) I.2-36: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6951 (0.6); 8.3351 (1.2); 8.3303 (1.2); 7.7654 (0.8); 7.7591 (0.8); 7.7449 (1.0); 7.7386 (0.9); 7.5429 (2.9); 7.5371 (0.8); 7.5256 (0.9); 7.5198 (3.2); 7.5002 (1.6); 7.4797 (1.3); 7.4781 (1.3); 6.9434 (3.2); 6.9376 (0.8); 6.9262 (0.8); 6.9204 (2.8); 5.7553 (0.6); 4.3371 (1.9); 4.3225 (1.9); 3.9873 (0.6); 3.9633 (1.0); 3.9415 (0.8); 3.8657 (0.9); 3.8501 (0.9); 3.8414 (0.6); 3.8257 (0.7); 3.7390 (16.0); 3.7197 (0.6); 3.3184 (142.9); 3.2776 (0.6); 3.2684 (1.1); 2.7434 (0.5); 2.7012 (1.1); 2.6780 (1.2); 2.6747 (0.8); 2.6700 (0.8); 2.6652 (0.6); 2.6563 (1.2); 2.6378 (1.1); 2.5234 (2.1); 2.5187 (3.1); 2.5100 (44.5); 2.5055 (97.6); 2.5008 (137.3); 2.4962 (96.0); 2.4916 (42.5); 2.4603 (0.7); 2.4557 (1.1); 2.4510 (1.3); 2.4464 (0.9); 2.4420 (0.6); 2.3323 (0.6); 2.3277 (0.9); 2.3230 (0.6); 2.0733 (0.6); 0.0080 (0.6); -0.0002 (19.7); -0.0085 (0.6) I.2-37: 1H-NMR (400.0 MHz, CDCl3): δ= 7.3917 (1.9); 7.3831 (1.5); 7.3771 (1.9); 7.3685 (2.6); 7.3008 (0.6); 7.2965 (0.8); 7.2820 (0.9); 7.2801 (0.9); 7.2777 (1.2); 7.2759 (1.1); 7.2705 (0.6); 7.2604 (23.7); 7.2572 (2.9); 7.2514 (2.3); 7.2456 (2.0); 7.2417 (1.8); 7.2368 (3.5); 7.0017 (0.8); 6.9986 (1.0); 6.9827 (1.3); 6.9796 (1.4); 6.9636 (0.7); 6.9604 (0.8); 6.9501 (1.4); 6.9473 (1.2); 6.9294 (1.2); 6.9266 (1.0); 4.5805 (3.4); 4.5658 (3.3); 4.0044 (0.9); 3.9882 (1.0); 3.9798 (1.3); 3.9636 (1.4); 3.8920 (1.4); 3.8712 (1.5); 3.8673 (1.0); 3.8465 (1.0); 3.7551 (16.0); 3.2475 (0.7); 2.9062 (0.8); 2.8875 (0.7); 2.8638 (1.6); 2.8451 (1.4); 2.7970 (1.4); 2.7734 (1.3); 2.7546 (0.7); 2.7310 (0.6); -0.0002 (7.2) I.2-38: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5225 (3.6); 8.5149 (3.5); 8.5021 (3.6); 7.6485 (10.4); 7.6431 (10.3); 7.6376 (4.0); 7.5019 (2.7); 7.4965 (3.6); 7.4836 (4.6); 7.4811 (4.7); 7.4785 (5.3); 7.4758 (7.1); 7.4494 (5.9); 7.4439 (5.8); 7.4286 (12.0); 7.4244 (9.6); 7.4088 (3.7); 7.4031 (3.4); 7.2675 (3.7); 7.2428 (16.0); 7.2403 (15.4); 7.2207 (15.7); 7.2154 (11.6); 7.2103 (10.3); 7.2042 (8.4); 7.1820 (2.9); 7.1636 (1.2); 7.0576 (5.8); 7.0551 (5.3); 6.9692 (5.1); 6.9493 (4.9); 5.3329 (1.9); 5.3136 (5.7); 5.2933 (5.7); 5.2736 (1.9); 4.0763 (2.4); 4.0520 (4.6); 4.0466 (2.8); 4.0302 (4.0); 4.0227 (4.5); 4.0011 (3.4); 3.9717 (3.7); 3.9567 (4.0); 3.9448 (4.2); 3.9299 (4.3); 3.9201 (2.4); 3.9053 (2.4); 3.3645 (3.4); 3.3135 (510.2); 3.2739 (6.9); 3.2577 (4.1); 3.2361 (1.6); 2.9796 (1.7); 2.9712 (2.0); 2.9571 (2.0); 2.9489 (2.2); 2.9396 (3.3); 2.9311 (3.5); 2.9172 (3.4); 2.9092 (3.3); 2.8542 (2.6); 2.8335 (5.4); 2.8130 (4.4); 2.8062 (2.5); 2.7972 (7.1); 2.7832 (2.4); 2.7743 (6.4); 2.7633 (10.5); 2.7447 (5.9); 2.7410 (6.0); 2.7328 (5.8); 2.7205 (2.4); 2.7145 (5.5); 2.7022 (1.9); 2.6900 (2.0); 2.6738 (5.6); 2.6694 (7.3); 2.6647 (5.1); 2.5553 (3.2); 2.5506 (3.6); 2.5460 (2.8); 2.5341 (5.0); 2.5228 (21.3); 2.5180 (31.5); 2.5093 (390.1); 2.5048 (831.9); 2.5002 (1151.0); 2.4956 (811.4); 2.4911 (366.7); 2.4688 (1.5); 2.4638 (1.2); 2.4510 (2.8); 2.4459 (2.6); 2.4345 (1.8); 2.4266 (2.3); 2.4145 (2.4); 2.4026 (3.1); 2.3960 (3.3); 2.3879 (2.3); 2.3316 (4.9); 2.3270 (6.8); 2.3224 (4.9); 2.0717 (1.5); 1.8445 (1.0); 1.8287 (2.6); 1.8231 (2.6); 1.8089 (2.4); 1.8032 (2.9); 1.7976 (2.6); 1.7915 (2.3); 1.7775 (2.5); 1.7717 (2.4); 1.7559 (1.1); 1.7501 (1.1); 0.9216 (0.7); 0.8583 (0.6); 0.0080 (1.5); -0.0002 (52.2); -0.0086 (1.3) I.2-39: 1H-NMR (400.0 MHz, CDCl3): δ= 7.4202 (0.5); 7.4118 (0.9); 7.3972 (0.9); 7.3909 (0.7); 7.3761 (0.6); 7.2933 (0.7); 7.2770 (2.9); 7.2731 (2.2); 7.2682 (5.2); 7.2594 (85.0); 7.2476 (0.8); 6.9401 (0.6); 6.9373 (0.7); 6.9312 (0.7); 6.9251 (1.2); 6.9200 (1.1); 6.9180 (1.2); 6.9101 (0.7); 6.9043 (1.5); 6.9000 (0.9); 6.8985 (0.9); 6.8832 (0.7); 5.5354 (0.9); 5.5163 (0.8); 4.1043 (0.7); 4.0864 (0.8); 4.0804 (1.0); 4.0626 (1.0); 3.9497 (1.1); 3.9278 (1.4); 3.9045 (0.9); 3.2430 (0.6); 3.2250 (0.6); 3.2223 (0.8); 3.2196 (0.7); 3.2016 (0.6); 3.0060 (0.6); 2.9956 (1.7); 2.9840 (0.6); 2.9749 (1.3); 2.9532 (1.7); 2.9420 (0.5); 2.9326 (1.6); 2.9223 (1.0); 2.9022 (0.7); 2.8213 (1.6); 2.7976 (1.5); 2.7788 (1.1); 2.7552 (0.9); 2.6534 (0.5); 2.6427 (0.6); 2.6209 (0.6); 2.6103 (0.5); 1.8480 (0.5); 1.5409 (16.0); 0.0080 (1.0); -0.0002 (32.4); -0.0085 (0.9) I.2-40: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5157 (3.5); 8.5035 (3.4); 8.4954 (3.2); 7.9893 (8.8); 7.7752 (4.5); 7.7575 (5.2); 7.5542 (2.9); 7.5337 (5.6); 7.5112 (2.9); 7.3773 (1.5); 7.3516 (6.0); 7.3310 (4.9); 7.2693 (3.8); 7.2508 (8.6); 7.2343 (7.1); 7.2236 (16.0); 7.2115 (11.6); 7.2027 (8.3); 7.1993 (8.2); 7.1807 (7.1); 7.0456 (7.8); 7.0418 (7.5); 6.9061 (3.6); 6.9022 (3.6); 5.3368 (2.1); 5.3173 (5.9); 5.2975 (5.8); 5.2779 (1.8); 4.3426 (0.8); 4.3241 (1.4); 4.1056 (2.3); 4.0815 (4.8); 4.0757 (2.7); 4.0599 (4.1); 4.0518 (4.5); 4.0303 (3.7); 3.9989 (4.0); 3.9842 (4.0); 3.9724 (4.6); 3.9574 (4.4); 3.9481 (2.4); 3.9330 (2.5); 3.3159 (380.2); 3.2513 (3.2); 2.9802 (1.7); 2.9715 (1.8); 2.9589 (1.8); 2.9487 (2.0); 2.9399 (3.5); 2.9313 (3.7); 2.9184 (4.0); 2.9097 (3.7); 2.8907 (1.2); 2.8693 (1.2); 2.8547 (2.4); 2.8466 (2.2); 2.8336 (5.1); 2.8235 (1.9); 2.8132 (5.7); 2.8040 (5.9); 2.7945 (3.5); 2.7811 (5.8); 2.7733 (8.5); 2.7555 (5.6); 2.7481 (6.1); 2.7437 (6.8); 2.7309 (2.2); 2.7253 (5.6); 2.7128 (1.6); 2.7012 (1.8); 2.6783 (2.9); 2.6739 (6.0); 2.6693 (8.7); 2.6647 (6.1); 2.5539 (6.0); 2.5494 (11.1); 2.5449 (10.2); 2.5402 (7.2); 2.5227 (26.3); 2.5180 (36.9); 2.5093 (483.2); 2.5048 (1053.6); 2.5002 (1473.3); 2.4956 (1048.9); 2.4910 (480.8); 2.4571 (1.3); 2.4361 (2.3); 2.4279 (3.1); 2.4167 (3.1); 2.4048 (3.0); 2.3975 (3.4); 2.3899 (2.6); 2.3697 (1.9); 2.3316 (7.0); 2.3270 (9.1); 2.3224 (6.7); 2.3178 (3.1); 2.0719 (1.8); 1.8501 (1.3); 1.8297 (3.5); 1.8197 (1.4); 1.8080 (3.5); 1.7985 (3.4); 1.7764 (3.1); 1.7546 (1.3); 1.7053 (0.8); 1.6836 (1.0); 1.2478 (3.4); 0.9110 (1.6); 0.8907 (0.9); 0.8747 (1.7); 0.8584 (6.1); 0.8407 (2.4); 0.0080 (1.9); -0.0002 (64.3); -0.0086 (2.0) I.2-41: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7289 (7.2); 7.9794 (7.8); 7.9747 (7.8); 7.5284 (4.8); 7.5230 (9.4); 7.5186 (5.9); 7.4529 (3.3); 7.4505 (3.8); 7.4477 (3.0); 7.4452 (3.0); 7.4321 (5.5); 7.4298 (5.6); 7.4270 (5.5); 7.4246 (4.8); 7.3768 (7.7); 7.3563 (12.2); 7.3357 (5.2); 7.3108 (0.6); 7.2601 (369.0); 7.2104 (0.7); 7.1773 (2.6); 6.9962 (2.1); 6.9415 (3.6); 6.9376 (3.6); 6.9214 (3.3); 6.9174 (3.2); 6.7141 (7.8); 6.5296 (16.0); 6.3450 (8.1); 4.7741 (10.1); 4.7632 (10.0); 4.2299 (5.5); 4.2113 (5.6); 4.2057 (6.7); 4.1872 (7.0); 4.0528 (6.3); 4.0313 (7.7); 4.0288 (6.0); 4.0072 (5.2); 3.4180 (1.2); 3.3965 (3.0); 3.3756 (3.5); 3.3546 (3.1); 3.3331 (1.3); 3.0692 (5.1); 3.0477 (4.3); 3.0266 (8.4); 3.0050 (7.9); 2.9357 (8.5); 2.9121 (7.8); 2.8930 (4.7); 2.8693 (4.2); 2.1350 (0.5); 1.6131 (3.4); 1.3655 (0.8); 0.0694 (0.7); 0.0080 (4.0); -0.0002 (133.3); -0.0086 (3.8); -0.1494 (0.5) I.2-42: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7265 (9.9); 7.9820 (10.5); 7.9774 (10.9); 7.9060 (4.9); 7.8852 (5.8); 7.8496 (10.0); 7.5186 (8.5); 7.5004 (8.5); 7.4801 (5.6); 7.4299 (7.6); 7.4105 (4.6); 7.3094 (2.3); 7.2945 (0.6); 7.2906 (1.3); 7.2875 (1.8); 7.2597 (961.1); 7.2267 (1.0); 7.2201 (0.9); 7.1987 (2.2); 7.1836 (3.8); 7.1600 (1.3); 6.9957 (5.5); 4.7781 (14.4); 4.7672 (14.2); 4.2752 (7.5); 4.2570 (8.1); 4.2512 (10.0); 4.2330 (9.9); 4.0919 (9.3); 4.0705 (11.2); 4.0680 (8.9); 4.0465 (7.6); 3.4381 (1.6); 3.4167 (4.3); 3.3959 (5.0); 3.3934 (4.8); 3.3751 (4.4); 3.3537 (1.9); 3.0851 (7.0); 3.0638 (5.8); 3.0423 (12.3); 3.0210 (11.4); 2.9567 (12.4); 2.9331 (11.5); 2.9140 (6.5); 2.8903 (6.0); 2.1352 (0.6); 2.0049 (1.1); 1.5577 (16.0); 1.4330 (1.5); 1.4147 (2.6); 1.3966 (1.3); 0.1460 (1.2); 0.0691 (0.8); 0.0496 (0.7); 0.0079 (10.5); -0.0002 (354.1); -0.0085 (10.4); -0.1496 (1.3) I.2-43: 1H-NMR (400.0 MHz, CDCl3): δ= 7.6507 (2.5); 7.6306 (5.3); 7.6099 (3.1); 7.4101 (3.5); 7.3911 (6.8); 7.3719 (3.5); 7.2595 (15.1); 7.1975 (5.1); 7.1788 (6.8); 7.1605 (5.3); 7.1292 (1.9); 7.0741 (1.2); 7.0542 (0.8); 6.9731 (0.7); 6.9559 (0.8); 6.9404 (0.6); 5.9440 (0.5); 4.9827 (0.7); 4.6648 (1.0); 4.6387 (1.1); 4.6001 (0.6); 4.5834 (0.9); 4.5692 (1.0); 4.5573 (0.8); 4.5440 (0.8); 3.7431 (0.8); 3.7175 (1.4); 3.6883 (1.6); 3.6618 (1.1); 3.2461 (0.8); 3.2119 (1.5); 3.1861 (1.0); 3.1708 (1.2); 3.1445 (0.8); 2.8481 (1.9); 2.7953 (1.9); 2.7712 (5.4); 2.7555 (4.9); 2.7316 (1.3); 2.7140 (1.5); 2.6965 (3.6); 2.6585 (7.5); 2.1085 (1.2); 2.0838 (1.6); 2.0378 (1.4); 2.0170 (1.5); 2.0008 (1.6); 1.9585 (0.7); 1.8846 (0.6); 1.8592 (1.1); 1.8451 (1.1); 1.8313 (1.1); 1.8152 (1.1); 1.7879 (0.8); 1.7499 (0.5); 1.6540 (4.6); 1.6074 (16.0); 1.5919 (2.6); -0.0002 (16.8); -0.0085 (0.5) I.2-46: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5204 (3.5); 7.3764 (1.6); 7.3237 (4.0); 7.3116 (5.6); 7.2616 (452.1); 7.2084 (1.4); 7.1618 (0.9); 7.1485 (1.8); 7.1434 (1.8); 7.1298 (4.4); 7.1085 (3.9); 7.0871 (1.2); 6.9975 (2.6); 5.8317 (1.0); 4.4717 (0.8); 4.4569 (0.8); 4.4347 (2.5); 4.4198 (2.5); 4.4072 (2.4); 4.3925 (2.4); 4.3704 (0.7); 4.3542 (0.7); 3.7090 (1.8); 3.6923 (1.9); 3.6847 (2.2); 3.6675 (2.3); 3.5350 (2.3); 3.5121 (2.8); 3.4890 (1.8); 3.1677 (1.1); 3.1482 (1.2); 3.1343 (2.4); 3.1142 (2.5); 3.0967 (0.7); 3.0855 (2.5); 3.0674 (2.5); 3.0524 (2.3); 3.0341 (2.0); 3.0145 (0.6); 2.7574 (1.1); 2.7368 (1.0); 2.7151 (2.7); 2.6948 (2.5); 2.6732 (2.8); 2.6492 (2.4); 2.6315 (1.0); 2.6074 (0.9); 1.9651 (0.7); 1.9475 (1.1); 1.9303 (1.7); 1.9131 (1.9); 1.8959 (1.7); 1.8787 (1.2); 1.6118 (2.5); 1.5610 (189.7); 1.5084 (0.9); 0.9148 (13.8); 0.9114 (16.0); 0.8982 (13.3); 0.8948 (15.2); 0.1458 (1.0); 0.0495 (1.2); 0.0078 (6.2); -0.0002 (133.1); -0.0083 (5.0); -0.1497 (0.7) I.2-48: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6804 (1.2); 8.6657 (2.4); 8.6510 (1.2); 7.6570 (6.6); 7.6542 (8.1); 7.6490 (2.1); 7.6399 (2.4); 7.6374 (4.4); 7.6350 (9.2); 7.6324 (7.8); 7.6266 (0.9); 7.4068 (1.0); 7.4006 (9.5); 7.3955 (4.1); 7.3908 (6.9); 7.3846 (4.9); 7.3792 (16.0); 7.3725 (9.4); 7.3694 (6.4); 7.3641 (1.0); 7.3554 (2.2); 7.3507 (6.7); 7.3452 (0.8); 7.3128 (1.6); 7.3068 (11.4); 7.3014 (3.2); 7.2904 (2.6); 7.2851 (7.2); 7.2790 (0.8); 7.1571 (1.7); 7.1543 (3.4); 7.1515 (1.9); 7.1359 (5.4); 7.1202 (1.4); 7.1174 (2.5); 7.1146 (1.3); 4.3072 (7.8); 4.2924 (7.7); 4.0428 (2.7); 4.0213 (3.9); 4.0186 (4.6); 3.9971 (3.9); 3.9145 (3.9); 3.8991 (4.1); 3.8902 (2.8); 3.8749 (2.9); 3.3373 (0.9); 3.3195 (142.6); 3.3037 (1.4); 3.2980 (2.1); 3.2810 (1.4); 3.2776 (1.1); 3.2747 (1.0); 3.2696 (1.2); 3.2594 (0.8); 2.7896 (2.4); 2.7664 (2.3); 2.7473 (5.5); 2.7241 (5.0); 2.6947 (5.4); 2.6764 (5.2); 2.6699 (0.9); 2.6653 (0.6); 2.6525 (2.3); 2.6341 (2.2); 2.5234 (1.5); 2.5188 (2.2); 2.5100 (33.9); 2.5054 (74.9); 2.5008 (104.6); 2.4962 (72.9); 2.4916 (32.0); 2.4555 (0.6); 2.4510 (0.9); 2.4463 (0.7); 2.3277 (0.7); 0.0081 (1.3); -0.0002 (48.6); -0.0086 (1.4) I.2-49: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6500 (2.0); 8.6348 (3.7); 8.6205 (2.0); 7.6604 (11.0); 7.6575 (13.6); 7.6524 (3.7); 7.6432 (4.2); 7.6407 (7.7); 7.6383 (15.5); 7.6357 (13.2); 7.6300 (1.7); 7.3960 (1.6); 7.3910 (10.8); 7.3858 (3.4); 7.3780 (2.2); 7.3725 (13.8); 7.3696 (10.9); 7.3643 (2.0); 7.3553 (6.0); 7.3511 (14.1); 7.3455 (1.9); 7.3359 (9.0); 7.3335 (12.2); 7.3311 (9.0); 7.3207 (4.7); 7.3158 (13.7); 7.3141 (10.1); 7.2809 (15.4); 7.2801 (16.0); 7.2745 (3.6); 7.2696 (5.9); 7.2670 (7.2); 7.2647 (8.3); 7.2633 (9.7); 7.2545 (3.1); 7.2489 (6.3); 7.2427 (1.4); 7.2351 (1.4); 7.2313 (2.2); 7.2275 (1.1); 7.1566 (3.0); 7.1539 (5.7); 7.1511 (3.2); 7.1354 (9.0); 7.1197 (2.4); 7.1170 (4.2); 7.1142 (2.2); 4.3235 (13.7); 4.3088 (13.5); 4.0466 (4.6); 4.0251 (6.6); 4.0224 (7.9); 4.0010 (6.8); 3.9226 (6.8); 3.9072 (7.1); 3.8983 (4.9); 3.8830 (5.0); 3.7288 (1.0); 3.3436 (1.3); 3.3189 (235.3); 3.3099 (3.8); 3.3042 (4.0); 3.2875 (2.4); 3.2837 (1.9); 3.2686 (1.7); 3.2655 (1.4); 2.7910 (3.9); 2.7679 (3.6); 2.7488 (9.6); 2.7257 (8.8); 2.7013 (9.4); 2.6830 (8.9); 2.6744 (1.1); 2.6696 (1.4); 2.6650 (1.1); 2.6591 (3.9); 2.6407 (3.5); 2.5231 (2.7); 2.5184 (4.2); 2.5097 (64.8); 2.5051 (142.5); 2.5005 (198.5); 2.4959 (138.8); 2.4913 (61.9); 2.4591 (0.7); 2.4549 (1.1); 2.4502 (1.5); 2.4456 (1.3); 2.3320 (0.9); 2.3273 (1.3); 2.3227 (0.9); 2.0731 (0.5); 0.0080 (2.5); 0.0063 (0.9); -0.0002 (85.7); -0.0060 (1.0); -0.0068 (1.0); -0.0085 (2.6) I.2-50: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6437 (0.6); 7.5448 (2.9); 7.5391 (0.9); 7.5277 (0.8); 7.5218 (3.2); 7.3993 (2.3); 7.3942 (0.8); 7.3831 (1.0); 7.3779 (3.7); 7.3030 (2.7); 7.2977 (0.8); 7.2814 (1.8); 6.9447 (3.1); 6.9389 (0.9); 6.9274 (0.8); 6.9217 (2.9); 4.3038 (1.8); 4.2890 (1.8); 3.9913 (0.6); 3.9695 (0.9); 3.9672 (1.1); 3.9455 (0.8); 3.8699 (0.8); 3.8543 (0.9); 3.8457 (0.6); 3.8302 (0.7); 3.7400 (16.0); 3.3119 (17.0); 2.7039 (1.2); 2.6806 (1.1); 2.6610 (1.3); 2.6424 (1.1); 2.5229 (0.7); 2.5182 (1.0); 2.5095 (12.3); 2.5050 (26.7); 2.5003 (37.2); 2.4957 (25.9); 2.4911 (11.5); -0.0002 (5.0) I.2-56: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6925 (2.2); 8.6775 (4.2); 8.6639 (2.1); 7.6562 (10.8); 7.6533 (12.9); 7.6482 (3.5); 7.6366 (7.7); 7.6342 (14.6); 7.6315 (12.3); 7.6238 (12.7); 7.6187 (12.8); 7.4455 (5.3); 7.4403 (4.6); 7.4247 (10.8); 7.4194 (10.6); 7.3924 (14.1); 7.3903 (16.0); 7.3741 (13.7); 7.3708 (12.6); 7.3573 (3.8); 7.3525 (10.2); 7.1585 (2.9); 7.1557 (5.3); 7.1530 (2.9); 7.1373 (8.4); 7.1216 (2.2); 7.1188 (3.8); 7.1161 (1.9); 4.3612 (12.7); 4.3468 (12.4); 4.0558 (4.2); 4.0343 (6.0); 4.0316 (6.8); 4.0101 (6.0); 3.9225 (6.0); 3.9072 (6.3); 3.8981 (4.3); 3.8829 (4.6); 3.5625 (0.7); 3.5190 (1.0); 3.3778 (1.1); 3.3556 (2.2); 3.3392 (4.0); 3.3185 (567.2); 3.3007 (2.0); 3.2686 (4.7); 2.8035 (3.9); 2.7803 (3.6); 2.7613 (8.3); 2.7380 (7.4); 2.7019 (8.0); 2.6838 (7.6); 2.6746 (2.0); 2.6700 (2.6); 2.6653 (2.0); 2.6597 (4.1); 2.6415 (3.6); 2.5235 (6.3); 2.5188 (9.4); 2.5101 (134.3); 2.5055 (292.0); 2.5009 (405.2); 2.4963 (283.0); 2.4917 (125.6); 2.4601 (1.8); 2.4557 (3.0); 2.4508 (3.6); 2.4463 (2.4); 2.3323 (1.8); 2.3277 (2.4); 2.3231 (1.8); 2.0854 (7.5); 2.0735 (1.6); 1.2358 (1.8); 0.8905 (1.7); 0.8739 (1.8); 0.8523 (0.6); 0.8436 (0.8); 0.8245 (0.8); 0.1461 (0.5); 0.0079 (4.8); -0.0002 (173.4); -0.0068 (2.1); -0.0085 (5.4); -0.0502 (1.2) I.2-58: 1H-NMR (400.0 MHz, CDCl3): δ= 8.5551 (0.5); 8.5527 (0.6); 8.5509 (0.6); 8.5485 (0.6); 8.5428 (0.6); 8.5404 (0.6); 8.5386 (0.6); 8.5362 (0.5); 7.7139 (0.6); 7.7094 (0.6); 7.6947 (1.0); 7.6902 (1.0); 7.6755 (0.7); 7.6710 (0.7); 7.4853 (3.0); 7.4795 (0.9); 7.4681 (0.9); 7.4623 (3.3); 7.2762 (1.0); 7.2609 (28.2); 7.2568 (1.2); 7.2512 (0.6); 7.2387 (0.5); 7.2323 (0.5); 6.9123 (3.2); 6.9066 (0.9); 6.8951 (0.9); 6.8894 (2.9); 4.6119 (2.3); 4.6003 (2.2); 4.1822 (0.9); 4.1632 (0.9); 4.1581 (1.1); 4.1391 (1.1); 3.9757 (1.1); 3.9541 (1.3); 3.9516 (1.0); 3.9299 (0.9); 3.7980 (16.0); 3.3089 (0.6); 3.3068 (0.6); 3.2876 (0.5); 3.0161 (0.8); 2.9941 (0.7); 2.9738 (1.3); 2.9517 (1.2); 2.8613 (1.3); 2.8376 (1.2); 2.8189 (0.8); 2.7953 (0.7); -0.0002 (12.2) I.2-59: 1H-NMR (400.0 MHz, CDCl3): δ= 8.5583 (3.7); 8.5559 (4.3); 8.5540 (4.5); 8.5516 (3.9); 8.5460 (3.9); 8.5436 (4.5); 8.5417 (4.4); 8.5393 (3.8); 7.7219 (4.0); 7.7174 (4.0); 7.7027 (7.1); 7.6982 (7.1); 7.6835 (4.8); 7.6791 (4.6); 7.6043 (10.8); 7.6014 (13.0); 7.5962 (3.6); 7.5872 (4.1); 7.5848 (7.6); 7.5823 (14.8); 7.5796 (13.2); 7.5739 (1.6); 7.5199 (1.2); 7.3954 (1.7); 7.3904 (10.6); 7.3888 (4.5); 7.3852 (3.5); 7.3772 (2.2); 7.3718 (13.2); 7.3693 (9.8); 7.3638 (1.7); 7.3550 (4.0); 7.3522 (4.1); 7.3503 (10.4); 7.3449 (1.4); 7.2835 (6.9); 7.2610 (218.3); 7.2560 (5.1); 7.2520 (1.2); 7.2512 (1.1); 7.2504 (1.0); 7.2464 (3.9); 7.2449 (3.6); 7.2434 (3.6); 7.2416 (3.0); 7.2399 (3.8); 7.2384 (3.3); 7.2370 (3.2); 7.2275 (3.5); 7.2261 (3.0); 7.2247 (2.9); 7.2112 (1.7); 7.1815 (3.1); 7.1787 (5.8); 7.1758 (3.3); 7.1637 (3.4); 7.1602 (9.0); 7.1583 (4.1); 7.1565 (3.0); 7.1444 (2.8); 7.1416 (4.8); 7.1388 (3.0); 7.1217 (2.1); 6.9970 (1.2); 4.6189 (16.0); 4.6072 (15.9); 4.2258 (6.5); 4.2066 (6.9); 4.2016 (8.1); 4.1824 (8.4); 4.0255 (7.8); 4.0039 (9.2); 4.0013 (7.4); 3.9797 (6.6); 3.3625 (1.4); 3.3401 (3.4); 3.3176 (4.0); 3.2979 (3.6); 3.2759 (1.6); 3.0454 (6.3); 3.0230 (5.2); 3.0029 (9.9); 2.9805 (9.1); 2.8848 (9.8); 2.8612 (9.0); 2.8423 (6.0); 2.8188 (5.4); 1.6779 (4.1); 0.0080 (2.4); -0.0002 (92.6); - 0.0085 (2.7); -0.0499 (0.8) I.2-60: 1H-NMR (400.0 MHz, CDCl3): δ= 7.3113 (0.7); 7.3069 (0.9); 7.2924 (1.0); 7.2905 (1.1); 7.2881 (1.3); 7.2863 (1.3); 7.2718 (1.2); 7.2672 (2.6); 7.2601 (32.4); 7.2472 (1.7); 7.2431 (1.2); 7.1180 (1.3); 7.1122 (1.4); 7.1002 (1.1); 7.0969 (1.7); 7.0918 (0.5); 7.0796 (1.5); 7.0674 (1.0); 7.0657 (0.8); 7.0582 (0.6); 7.0469 (0.7); 7.0120 (1.0); 7.0089 (1.1); 6.9930 (1.4); 6.9899 (1.6); 6.9738 (0.8); 6.9707 (0.9); 6.9651 (1.5); 6.9623 (1.2); 6.9444 (1.3); 6.9415 (1.1); 4.5671 (2.2); 4.5523 (2.1); 3.9973 (1.0); 3.9819 (1.0); 3.9724 (1.5); 3.9570 (1.5); 3.8965 (1.5); 3.8761 (1.7); 3.8717 (1.1); 3.8512 (1.0); 3.7881 (16.0); 3.2466 (0.8); 2.8907 (0.6); 2.8728 (0.6); 2.8483 (1.9); 2.8304 (1.8); 2.8163 (1.9); 2.7929 (1.8); 2.7739 (0.6); 2.7505 (0.6); -0.0002 (12.7) I.2-61: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5492 (3.1); 7.5434 (1.1); 7.5373 (3.2); 7.5317 (1.8); 7.5262 (3.3); 7.5198 (1.2); 7.5143 (3.2); 7.2596 (103.2); 7.1450 (0.7); 7.1393 (1.4); 7.1345 (0.8); 7.1276 (0.7); 7.1207 (1.2); 7.1155 (2.9); 7.1013 (2.3); 7.0936 (2.0); 7.0825 (1.6); 7.0805 (1.5); 7.0775 (3.8); 7.0722 (1.8); 7.0658 (0.9); 7.0601 (1.6); 7.0569 (4.6); 7.0546 (3.8); 7.0453 (0.6); 7.0397 (1.1); 7.0339 (3.1); 6.9956 (0.6); 5.9914 (0.6); 4.5727 (3.1); 4.5578 (3.0); 4.1673 (1.7); 4.1489 (1.9); 4.1433 (2.2); 4.1249 (2.2); 3.9427 (2.2); 3.9211 (2.6); 3.9186 (2.1); 3.8971 (1.8); 3.1899 (1.0); 3.1715 (1.0); 3.1688 (1.2); 3.1663 (1.2); 3.1478 (1.1); 2.9551 (1.5); 2.9336 (1.2); 2.9127 (2.8); 2.8912 (2.5); 2.8344 (2.8); 2.8105 (2.5); 2.7920 (1.4); 2.7681 (1.2); 1.5434 (16.0); 0.0080 (1.1); -0.0002 (36.1); -0.0085 (1.1) I.2-62: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5551 (0.5); 7.5462 (4.4); 7.5404 (1.5); 7.5343 (4.5); 7.5287 (2.6); 7.5231 (4.8); 7.5170 (1.6); 7.5112 (4.6); 7.4093 (3.2); 7.4038 (1.5); 7.4015 (2.8); 7.3975 (3.8); 7.3960 (3.0); 7.3913 (1.6); 7.3858 (4.4); 7.3769 (0.7); 7.2910 (1.0); 7.2870 (0.6); 7.2798 (5.0); 7.2779 (5.0); 7.2727 (3.0); 7.2679 (4.1); 7.2661 (4.3); 7.2596 (114.1); 7.2557 (8.4); 7.0821 (0.6); 7.0732 (5.1); 7.0673 (1.7); 7.0615 (0.7); 7.0558 (1.8); 7.0526 (5.8); 7.0502 (5.0); 7.0469 (1.7); 7.0412 (0.6); 7.0354 (1.4); 7.0295 (4.4); 6.9956 (0.6); 6.0423 (0.9); 4.5866 (8.5); 4.5718 (8.2); 4.1655 (2.6); 4.1470 (2.7); 4.1414 (3.1); 4.1229 (3.2); 3.9350 (3.0); 3.9135 (3.7); 3.9110 (3.0); 3.8895 (2.6); 3.7847 (1.5); 3.2102 (0.6); 3.1885 (1.4); 3.1700 (1.4); 3.1675 (1.6); 3.1649 (1.6); 3.1464 (1.5); 3.1435 (0.9); 3.1249 (0.7); 2.9576 (2.3); 2.9360 (1.8); 2.9152 (4.0); 2.8936 (3.5); 2.8266 (4.0); 2.8028 (3.5); 2.7842 (2.2); 2.7604 (1.9); 1.5486 (16.0); 0.0079 (1.2); -0.0002 (41.1); -0.0085 (1.3) I.2-63: 1H-NMR (400.0 MHz, CDCl3): δ= 8.5469 (3.9); 8.5444 (4.5); 8.5427 (4.6); 8.5403 (4.0); 8.5346 (4.1); 8.5322 (4.5); 8.5304 (4.4); 8.5280 (3.8); 7.7052 (4.0); 7.7008 (4.0); 7.6860 (7.3); 7.6815 (7.3); 7.6668 (4.8); 7.6624 (4.6); 7.5227 (0.7); 7.2637 (133.3); 7.2439 (8.4); 7.2427 (8.6); 7.2303 (3.7); 7.2289 (3.4); 7.2276 (3.4); 7.2256 (2.8); 7.2239 (3.7); 7.2212 (2.9); 7.2115 (3.3); 7.2102 (3.0); 7.2088 (2.8); 7.0238 (2.2); 6.9997 (1.2); 4.5821 (16.0); 4.5704 (15.7); 4.5374 (1.0); 4.5167 (3.5); 4.4965 (4.7); 4.4765 (2.9); 4.4567 (0.7); 3.6664 (4.3); 3.6481 (4.8); 3.6422 (6.6); 3.6239 (7.0); 3.5586 (6.8); 3.5370 (8.2); 3.5347 (5.6); 3.5128 (5.0); 3.1933 (1.4); 3.1749 (1.8); 3.1719 (3.3); 3.1536 (3.2); 3.1508 (3.9); 3.1480 (3.7); 3.1297 (3.4); 3.1267 (2.1); 3.1084 (1.5); 2.7938 (4.7); 2.7726 (4.2); 2.7520 (9.3); 2.7308 (8.7); 2.6794 (9.8); 2.6554 (9.1); 2.6376 (4.9); 2.6136 (4.4); 2.1074 (1.4); 1.8792 (1.0); 1.8659 (2.1); 1.8619 (2.1); 1.8541 (3.6); 1.8503 (2.8); 1.8456 (2.9); 1.8429 (2.9); 1.8340 (4.2); 1.8228 (2.4); 1.8130 (1.6); 1.8084 (2.0); 1.7278 (0.8); 1.7169 (1.5); 1.7104 (2.1); 1.7041 (2.9); 1.6937 (4.3); 1.6898 (5.0); 1.6821 (4.5); 1.6734 (5.5); 1.6685 (4.7); 1.6522 (3.1); 1.6396 (3.1); 1.6301 (1.6); 1.6207 (2.7); 1.6148 (3.3); 1.6085 (3.1); 1.6061 (3.4); 1.6007 (3.8); 1.5866 (4.6); 1.5783 (5.5); 1.5731 (3.7); 1.5624 (2.5); 1.5521 (2.4); 1.5433 (1.7); 1.5343 (1.6); 1.5222 (1.9); 1.5095 (1.5); 1.5019 (1.8); 1.4912 (1.7); 1.4725 (1.4); 0.0080 (1.4); -0.0002 (51.4); -0.0085 (1.5) I.2-64: 1H-NMR (400.0 MHz, CDCl3): δ= 8.5566 (4.0); 8.5524 (4.7); 8.5499 (4.2); 8.5443 (4.3); 8.5419 (4.8); 8.5377 (4.1); 7.7210 (3.9); 7.7165 (3.9); 7.7018 (7.3); 7.6974 (7.0); 7.6826 (4.8); 7.6781 (4.6); 7.5810 (1.0); 7.5720 (10.6); 7.5663 (3.9); 7.5601 (11.2); 7.5545 (6.7); 7.5489 (12.2); 7.5428 (4.3); 7.5370 (11.8); 7.5281 (1.5); 7.5191 (1.9); 7.2796 (7.3); 7.2602 (304.7); 7.2461 (5.8); 7.2448 (5.4); 7.2434 (5.4); 7.2414 (4.7); 7.2396 (5.2); 7.2370 (4.5); 7.2273 (4.6); 7.1111 (2.3); 7.0899 (2.1); 7.0811 (12.8); 7.0752 (4.2); 7.0693 (2.1); 7.0637 (5.1); 7.0604 (14.4); 7.0579 (12.9); 7.0546 (4.6); 7.0489 (1.9); 7.0431 (4.1); 7.0372 (11.3); 7.0283 (1.3); 6.9962 (1.8); 4.6152 (16.0); 4.6036 (16.0); 4.2000 (6.3); 4.1813 (6.9); 4.1760 (7.8); 4.1573 (8.1); 3.9926 (7.6); 3.9710 (9.3); 3.9686 (7.4); 3.9470 (6.6); 3.3593 (1.4); 3.3375 (3.5); 3.3187 (3.6); 3.3165 (3.9); 3.3142 (3.9); 3.2954 (3.7); 3.2924 (2.3); 3.2737 (1.6); 3.0282 (5.7); 3.0064 (4.8); 2.9857 (9.5); 2.9638 (8.7); 2.8820 (9.5); 2.8583 (8.8); 2.8394 (5.6); 2.8158 (5.0); 1.6538 (2.2); 1.2553 (0.9); 0.0079 (4.0); -0.0002 (109.2); -0.0085 (3.6) I.2-65: 1H-NMR (600.1 MHz, CD3CN): δ= 8.5099 (4.8); 8.5088 (4.9); 8.5019 (5.0); 8.5008 (4.9); 7.7267 (3.6); 7.7237 (3.7); 7.7139 (6.9); 7.7109 (6.9); 7.7011 (4.1); 7.6981 (4.1); 7.2815 (7.2); 7.2684 (6.8); 7.2333 (3.7); 7.2324 (3.8); 7.2315 (3.6); 7.2252 (3.8); 7.2243 (4.0); 7.2234 (3.9); 7.2219 (3.2); 7.2208 (4.0); 7.2199 (3.9); 7.2190 (3.6); 7.2127 (3.6); 7.2118 (3.7); 7.2109 (3.4); 7.1179 (1.5); 4.5484 (0.9); 4.5338 (2.3); 4.5197 (4.1); 4.5061 (2.4); 4.5043 (2.4); 4.4904 (1.1); 4.4543 (16.0); 4.4447 (15.9); 3.6815 (5.3); 3.6657 (8.5); 3.6511 (7.3); 3.5582 (6.7); 3.5478 (7.1); 3.5422 (5.4); 3.5318 (5.5); 3.1796 (1.7); 3.1692 (1.9); 3.1668 (2.3); 3.1647 (3.0); 3.1564 (2.3); 3.1540 (3.3); 3.1521 (3.4); 3.1500 (2.5); 3.1414 (2.9); 3.1396 (2.4); 3.1372 (2.0); 3.1267 (1.6); 2.5327 (1.4); 2.5199 (1.7); 2.5049 (12.6); 2.4985 (13.0); 2.4922 (12.0); 2.4831 (12.1); 2.4707 (1.5); 2.4554 (1.7); 2.2529 (0.8); 2.2505 (0.6); 2.2474 (0.9); 2.2404 (0.7); 2.2365 (2.6); 2.2336 (2.6); 2.2311 (3.3); 2.2243 (1.7); 2.2198 (3.5); 2.2175 (4.6); 2.2145 (4.6); 2.2124 (3.9); 2.2080 (1.9); 2.2011 (3.5); 2.1981 (3.0); 2.1954 (2.9); 2.1845 (1.2); 2.1814 (0.8); 2.1790 (1.1); 2.1385 (85.9); 2.0632 (0.4); 2.0606 (0.4); 2.0572 (1.0); 2.0540 (1.2); 2.0499 (2.6); 2.0459 (3.4); 2.0441 (3.2); 2.0419 (2.1); 2.0382 (4.6); 2.0331 (5.2); 2.0313 (4.5); 2.0262 (5.2); 2.0206 (4.1); 2.0185 (3.4); 2.0138 (3.4); 2.0080 (1.8); 2.0058 (1.3); 2.0035 (1.0); 2.0011 (1.1); 1.9952 (0.4); 1.9633 (8.2); 1.9552 (8.9); 1.9511 (10.1); 1.9472 (58.1); 1.9432 (102.5); 1.9390 (148.1); 1.9349 (100.8); 1.9308 (50.4); 1.9220 (1.0); 1.8281 (0.6); 1.8240 (0.8); 1.8199 (0.6); 1.7218 (0.5); 1.7093 (0.7); 1.7040 (1.8); 1.6914 (3.2); 1.6868 (3.8); 1.6822 (2.2); 1.6805 (2.8); 1.6744 (5.8); 1.6694 (3.4); 1.6662 (4.2); 1.6646 (4.6); 1.6629 (4.0); 1.6608 (2.9); 1.6593 (2.9); 1.6575 (3.2); 1.6551 (1.4); 1.6532 (1.6); 1.6502 (2.2); 1.6486 (2.6); 1.6465 (2.3); 1.6445 (1.5); 1.6431 (1.3); 1.6370 (0.3); 1.6322 (0.4); 1.6307 (0.3); -0.0001 (10.2); -0.0057 (0.4) I.2-66: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6963 (1.2); 8.6821 (2.1); 8.6681 (1.0); 7.7120 (1.2); 7.7041 (10.6); 7.6985 (3.0); 7.6869 (3.6); 7.6813 (12.6); 7.6733 (1.1); 7.6591 (2.0); 7.6522 (3.7); 7.6452 (2.1); 7.5111 (2.2); 7.5087 (4.3); 7.5045 (2.8); 7.4907 (2.9); 7.4865 (6.1); 7.4842 (2.7); 7.4643 (2.8); 7.4599 (1.0); 7.4429 (5.4); 7.4400 (16.0); 7.4345 (3.5); 7.4228 (3.6); 7.4174 (12.2); 7.4091 (1.3); 7.4006 (14.9); 7.3965 (4.0); 7.3825 (3.7); 7.3760 (1.8); 7.3650 (2.1); 7.3585 (1.4); 7.3441 (2.8); 7.3376 (2.6); 7.3231 (0.9); 7.3165 (1.0); 4.3713 (6.6); 4.3571 (6.4); 4.2897 (0.5); 4.2746 (0.6); 4.0594 (2.2); 4.0379 (3.7); 4.0351 (3.8); 4.0137 (3.7); 3.9168 (2.9); 3.9020 (3.0); 3.8925 (2.1); 3.8778 (2.3); 3.8265 (6.8); 3.3225 (62.5); 2.8283 (2.2); 2.8050 (2.2); 2.7860 (3.8); 2.7625 (3.4); 2.6962 (3.7); 2.6789 (4.2); 2.6748 (2.1); 2.6701 (2.6); 2.6655 (1.8); 2.6538 (1.9); 2.6364 (1.9); 2.5508 (0.9); 2.5348 (1.3); 2.5237 (7.6); 2.5190 (10.5); 2.5103 (143.4); 2.5057 (315.4); 2.5010 (445.4); 2.4964 (310.1); 2.4918 (136.1); 2.4600 (2.6); 2.4556 (4.1); 2.4511 (5.1); 2.4465 (3.8); 2.4065 (0.7); 2.3324 (2.1); 2.3279 (2.8); 2.3232 (2.0); 2.0734 (1.1); 1.4995 (1.5); 1.4767 (3.0); 0.9406 (2.0); 0.9264 (2.9); 0.9232 (3.8); 0.9051 (1.3); 0.8826 (0.6); 0.8583 (0.8); -0.0002 (10.5) I.2-67: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7285 (1.5); 8.7136 (2.7); 8.6995 (1.4); 8.3359 (5.4); 8.3311 (5.1); 7.7665 (3.9); 7.7602 (3.7); 7.7459 (4.4); 7.7396 (4.2); 7.7120 (1.5); 7.7039 (13.0); 7.6984 (3.9); 7.6868 (4.3); 7.6812 (15.3); 7.6732 (1.3); 7.4994 (7.1); 7.4775 (5.9); 7.4437 (1.8); 7.4358 (16.0); 7.4303 (4.1); 7.4186 (3.8); 7.4131 (13.1); 7.4051 (1.0); 5.7554 (1.1); 4.3365 (8.3); 4.3220 (8.2); 4.0297 (2.6); 4.0054 (4.5); 3.9838 (3.7); 3.8975 (3.8); 3.8823 (4.1); 3.8732 (2.8); 3.8580 (2.8); 3.3701 (1.0); 3.3187 (399.0); 3.2906 (2.9); 3.2690 (4.0); 3.2517 (0.9); 3.2189 (0.5); 2.7965 (2.5); 2.7732 (2.3); 2.7540 (5.0); 2.7308 (4.7); 2.6924 (5.3); 2.6745 (6.8); 2.6699 (3.4); 2.6655 (2.2); 2.6500 (2.2); 2.6320 (2.4); 2.5556 (1.3); 2.5234 (8.8); 2.5187 (12.8); 2.5101 (164.1); 2.5055 (357.8); 2.5009 (501.3); 2.4963 (353.8); 2.4917 (160.4); 2.4556 (3.5); 2.4512 (3.8); 2.4011 (1.0); 2.3323 (2.4); 2.3277 (3.2); 2.3230 (2.3); 2.0735 (1.6); 0.0080 (2.5); -0.0002 (92.6); -0.0085 (3.0); -0.0499 (0.6) I.2-68: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5195 (1.6); 7.4057 (3.9); 7.3958 (1.5); 7.3915 (5.0); 7.3827 (8.0); 7.3706 (18.8); 7.3649 (20.2); 7.3470 (5.4); 7.3284 (16.9); 7.3071 (28.4); 7.2607 (270.8); 7.2485 (15.5); 7.2422 (13.8); 7.2271 (9.0); 7.2209 (8.2); 6.9966 (1.6); 6.9373 (3.3); 6.9346 (2.0); 6.9301 (5.2); 6.9276 (6.5); 6.9238 (6.7); 6.9178 (9.2); 6.9154 (5.3); 6.9102 (10.4); 6.9082 (10.8); 6.9028 (8.2); 6.8968 (13.2); 6.8904 (10.4); 6.8836 (2.1); 6.8762 (6.6); 6.8694 (4.0); 6.1072 (3.8); 4.5768 (1.2); 4.5618 (1.2); 4.5392 (15.9); 4.5337 (16.0); 4.5242 (15.6); 4.5186 (15.6); 4.4963 (1.1); 4.4811 (1.1); 4.0477 (5.9); 4.0296 (6.5); 4.0236 (9.3); 4.0056 (9.4); 3.9395 (10.3); 3.9180 (12.2); 3.8943 (7.2); 3.2999 (2.2); 3.2790 (5.3); 3.2609 (5.3); 3.2582 (6.8); 3.2555 (6.1); 3.2375 (5.6); 3.2167 (2.4); 2.9298 (8.6); 2.9092 (7.5); 2.8872 (15.3); 2.8666 (14.2); 2.8004 (15.0); 2.7768 (13.9); 2.7579 (8.1); 2.7343 (7.3); 1.5678 (4.4); 1.2577 (0.8); 0.0079 (3.2); -0.0002 (101.3); - 0.0085 (2.9) I.2-69: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7236 (2.9); 7.9669 (3.1); 7.9655 (3.2); 7.9620 (3.1); 7.5196 (1.4); 7.3110 (0.8); 7.2775 (0.6); 7.2767 (0.7); 7.2751 (0.8); 7.2744 (0.8); 7.2727 (1.0); 7.2720 (1.2); 7.2711 (1.2); 7.2687 (2.4); 7.2680 (2.5); 7.2672 (2.8); 7.2663 (3.3); 7.2655 (4.2); 7.2647 (5.2); 7.2607 (255.0); 7.2566 (2.5); 7.2557 (1.4); 7.2549 (1.1); 7.2541 (0.8); 7.2533 (0.5); 7.2105 (1.8); 7.0812 (0.9); 6.9967 (1.4); 4.7451 (4.0); 4.7344 (3.9); 3.7383 (1.9); 3.7211 (2.1); 3.7139 (2.6); 3.6966 (2.7); 3.5906 (2.7); 3.5689 (3.3); 3.5662 (2.4); 3.5444 (2.3); 3.2811 (0.5); 3.2602 (0.9); 3.2394 (1.4); 3.2187 (1.0); 3.2149 (0.7); 3.1977 (0.5); 3.1758 (0.8); 3.1564 (0.8); 3.1421 (2.5); 3.1226 (2.6); 3.1111 (2.4); 3.0928 (2.4); 3.0773 (0.8); 3.0588 (0.8); 2.8336 (1.1); 2.8137 (1.0); 2.7918 (2.6); 2.7716 (2.5); 2.7404 (2.5); 2.7160 (2.3); 2.6980 (1.0); 2.6737 (0.9); 2.1370 (0.6); 1.9670 (0.5); 1.9487 (1.0); 1.9318 (1.4); 1.9151 (1.1); 1.8961 (0.6); 1.5825 (3.0); 0.9278 (16.0); 0.9245 (16.0); 0.9111 (15.9); 0.9078 (15.6); 0.0079 (3.4); 0.0064 (0.9); 0.0055 (1.0); 0.0047 (1.3); -0.0002 (109.2); -0.0051 (1.4); -0.0059 (1.2); -0.0068 (1.0); -0.0085 (3.1); -0.0504 (0.8) I.2-70: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7233 (11.7); 8.7207 (11.6); 7.9672 (13.0); 7.9658 (13.2); 7.9623 (12.9); 7.9610 (12.2); 7.5198 (4.3); 7.3111 (2.0); 7.2834 (1.1); 7.2785 (1.8); 7.2746 (2.4); 7.2706 (4.1); 7.2610 (763.5); 7.2569 (5.6); 7.2560 (3.4); 7.2552 (2.2); 7.2544 (1.7); 7.2536 (1.2); 7.2527 (1.4); 7.2520 (1.3); 7.2504 (0.9); 7.2496 (0.8); 7.2488 (0.8); 7.2109 (6.9); 7.1610 (0.7); 7.0886 (4.1); 6.9969 (4.5); 4.7429 (15.6); 4.7318 (15.3); 4.6851 (0.6); 4.5543 (1.5); 4.5333 (5.4); 4.5131 (7.2); 4.4930 (4.4); 4.4733 (1.1); 3.6977 (6.5); 3.6799 (7.4); 3.6734 (10.0); 3.6556 (10.7); 3.5894 (10.2); 3.5680 (12.4); 3.5654 (8.2); 3.5437 (7.6); 3.2522 (2.1); 3.2314 (4.7); 3.2136 (4.5); 3.2105 (5.9); 3.2074 (5.3); 3.1895 (4.7); 3.1864 (3.1); 3.1685 (2.1); 2.8173 (6.3); 2.7966 (5.7); 2.7755 (15.2); 2.7548 (14.2); 2.7268 (16.0); 2.7028 (15.1); 2.6850 (6.6); 2.6611 (6.0); 2.1370 (0.8); 1.8691 (5.2); 1.8600 (4.6); 1.8490 (6.1); 1.8238 (3.1); 1.7157 (3.8); 1.7056 (5.6); 1.7012 (6.9); 1.6936 (5.1); 1.6857 (5.8); 1.6800 (4.4); 1.6638 (3.5); 1.6520 (5.2); 1.6277 (8.4); 1.6189 (9.8); 1.6129 (10.3); 1.6024 (9.4); 1.5915 (9.9); 1.5652 (4.2); 1.5377 (3.2); 1.5179 (2.9); 1.5070 (2.7); 1.4884 (2.1); 1.4376 (1.0); 1.4190 (1.7); 1.4006 (0.9); 1.2562 (0.6); 0.1461 (0.9); 0.0690 (2.7); 0.0499 (0.6); 0.0080 (8.8); -0.0002 (343.2); -0.0085 (9.8); -0.0503 (3.3); -0.1498 (0.9) I.2-71: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5189 (1.1); 7.4090 (1.8); 7.3943 (2.1); 7.3860 (3.3); 7.3712 (3.2); 7.3652 (2.2); 7.3503 (2.2); 7.3101 (0.5); 7.2928 (0.8); 7.2912 (0.8); 7.2888 (0.9); 7.2857 (1.1); 7.2832 (1.2); 7.2816 (1.4); 7.2808 (1.4); 7.2800 (1.5); 7.2792 (1.5); 7.2784 (1.6); 7.2776 (1.7); 7.2768 (1.8); 7.2761 (1.8); 7.2752 (1.9); 7.2745 (2.0); 7.2737 (2.1); 7.2729 (2.2); 7.2721 (2.3); 7.2713 (2.4); 7.2704 (2.7); 7.2697 (2.8); 7.2689 (3.0); 7.2681 (3.3); 7.2672 (3.7); 7.2601 (191.3); 7.2544 (3.2); 7.2535 (2.4); 7.2527 (1.9); 7.2519 (1.5); 7.2511 (1.1); 7.2503 (1.0); 7.2495 (0.8); 7.2487 (0.7); 7.2479 (0.6); 7.1588 (0.9); 7.1535 (1.0); 7.1394 (1.8); 7.1337 (3.4); 7.1288 (2.2); 7.1222 (2.1); 7.1152 (3.1); 7.1097 (6.6); 7.0955 (5.9); 7.0886 (5.1); 7.0776 (3.4); 7.0758 (2.9); 7.0677 (2.5); 7.0640 (1.4); 7.0583 (1.1); 7.0533 (1.3); 7.0482 (0.7); 7.0393 (0.5); 7.0362 (0.6); 6.9960 (1.1); 6.9381 (1.6); 6.9355 (1.1); 6.9311 (2.4); 6.9285 (3.0); 6.9245 (3.1); 6.9186 (4.0); 6.9162 (2.6); 6.9111 (4.5); 6.9091 (4.7); 6.9035 (3.5); 6.8974 (5.6); 6.8913 (4.4); 6.8845 (0.9); 6.8764 (2.6); 6.8702 (1.6); 5.9992 (1.7); 4.5669 (8.4); 4.5520 (8.0); 4.0427 (2.5); 4.0234 (2.9); 4.0185 (4.0); 4.0006 (3.9); 3.9342 (4.3); 3.9124 (5.2); 3.8889 (3.0); 3.2770 (1.0); 3.2562 (2.4); 3.2381 (2.4); 3.2354 (3.0); 3.2327 (2.6); 3.2147 (2.4); 3.1939 (1.0); 2.9285 (3.7); 2.9080 (3.2); 2.8860 (6.4); 2.8654 (5.9); 2.7943 (6.3); 2.7707 (5.8); 2.7518 (3.5); 2.7282 (3.1); 1.5464 (16.0); 1.2583 (0.5); 0.0144 (0.7); 0.0136 (0.8); 0.0080 (2.9); 0.0064 (1.8); -0.0002 (75.2); -0.0085 (2.4) I.2-72: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7179 (3.3); 8.7035 (5.9); 8.6903 (3.4); 7.6190 (12.0); 7.4690 (3.9); 7.4478 (10.2); 7.4344 (9.8); 7.4154 (16.0); 7.3944 (4.4); 7.3667 (2.2); 7.3474 (4.5); 7.3276 (4.9); 7.3218 (5.2); 7.3080 (3.3); 7.2312 (14.4); 7.2170 (2.8); 7.2058 (2.9); 7.1965 (5.8); 7.1855 (7.5); 7.1782 (9.3); 7.1704 (10.1); 7.0461 (6.8); 6.9611 (5.6); 6.9415 (5.5); 4.3919 (13.8); 4.3780 (14.1); 4.0521 (4.4); 4.0285 (8.4); 4.0061 (5.8); 3.9090 (5.9); 3.8939 (6.3); 3.8838 (5.8); 3.8697 (5.3); 3.3226 (25.2); 2.8171 (4.0); 2.7938 (3.8); 2.7746 (7.5); 2.7512 (6.9); 2.6931 (7.7); 2.6753 (9.2); 2.6510 (4.5); 2.6332 (4.3); 2.5043 (449.7); 2.5001 (613.5); 2.4958 (479.2); 2.3270 (3.8); 1.4336 (2.0); 1.1642 (0.6); 0.9077 (1.8); 0.8898 (2.4); 0.1458 (0.9); -0.0002 (190.4); -0.1496 (0.9) I.2-73: 1H-NMR (400.0 MHz, CDCl3): δ= 7.8781 (4.0); 7.8571 (4.6); 7.8297 (8.2); 7.5184 (5.0); 7.5098 (3.3); 7.4907 (7.0); 7.4700 (4.6); 7.4229 (9.6); 7.4035 (4.1); 7.3946 (10.8); 7.3884 (11.5); 7.3417 (10.4); 7.3204 (16.9); 7.2935 (4.6); 7.2726 (8.6); 7.2596 (873.2); 7.2412 (5.9); 7.2350 (5.1); 7.1899 (2.8); 7.1836 (2.6); 7.1694 (1.7); 7.1628 (1.6); 6.9956 (4.6); 6.0424 (2.3); 4.5950 (0.9); 4.5580 (11.2); 4.5432 (10.7); 4.5401 (10.6); 4.2300 (5.9); 4.2116 (6.3); 4.2060 (7.3); 4.1875 (7.4); 4.0165 (6.6); 3.9950 (8.4); 3.9925 (6.7); 3.9710 (5.8); 3.9238 (9.6); 3.2502 (1.3); 3.2287 (3.2); 3.2077 (4.0); 3.1866 (3.6); 3.1651 (1.4); 2.9974 (5.2); 2.9759 (4.0); 2.9547 (10.0); 2.9332 (8.8); 2.8842 (9.9); 2.8604 (8.7); 2.8415 (4.7); 2.8178 (4.3); 2.0453 (1.1); 1.5654 (16.0); 1.2837 (1.0); 1.2565 (2.0); 0.1458 (1.0); 0.0079 (10.1); -0.0002 (335.2); -0.0085 (9.6); -0.1495 (1.1) I.2-74: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7153 (3.8); 8.7013 (6.2); 8.6868 (3.4); 7.9615 (11.1); 7.7503 (6.2); 7.7295 (6.8); 7.5418 (5.7); 7.5221 (10.5); 7.5023 (5.6); 7.3732 (2.2); 7.3665 (2.8); 7.3469 (9.8); 7.3215 (8.8); 7.3077 (2.3); 7.2174 (2.4); 7.1978 (6.1); 7.1851 (10.3); 7.1810 (8.9); 7.1736 (14.0); 7.1617 (6.7); 7.1461 (2.0); 7.0339 (15.3); 6.8945 (7.6); 4.3958 (16.0); 4.3815 (15.7); 4.0807 (5.9); 4.0566 (10.0); 4.0351 (8.0); 3.9381 (8.2); 3.9231 (8.9); 3.9139 (6.4); 3.8990 (6.3); 3.3588 (6.3); 3.3075 (657.4); 3.2827 (2.6); 3.2582 (4.8); 2.8238 (5.9); 2.8005 (5.5); 2.7813 (11.2); 2.7581 (10.3); 2.7044 (11.7); 2.6868 (10.8); 2.6739 (6.8); 2.6692 (10.1); 2.6622 (8.3); 2.6444 (6.2); 2.5551 (13.6); 2.5505 (14.7); 2.5456 (14.4); 2.5227 (65.2); 2.5179 (83.1); 2.5093 (562.0); 2.5048 (1152.6); 2.5002 (1565.7); 2.4956 (1106.5); 2.4910 (506.6); 2.4688 (3.6); 2.4554 (7.4); 2.4507 (9.0); 2.4460 (6.2); 2.3997 (1.8); 2.3317 (6.8); 2.3270 (9.2); 2.3224 (6.6); 1.2339 (1.5); 0.1458 (2.2); 0.0498 (3.1); 0.0080 (24.0); -0.0002 (669.3); -0.0085 (22.5); -0.0326 (1.3); -0.0497 (4.0); -0.1495 (2.2) I.2-75: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5021 (0.8); 7.4967 (1.6); 7.4912 (0.9); 7.4202 (0.6); 7.4129 (1.4); 7.4057 (1.1); 7.4002 (1.9); 7.3967 (1.4); 7.3943 (1.7); 7.3918 (2.0); 7.3603 (1.3); 7.3400 (1.9); 7.3195 (0.8); 7.2839 (1.8); 7.2823 (1.8); 7.2769 (1.1); 7.2724 (1.5); 7.2705 (1.6); 7.2662 (1.6); 7.2595 (79.6); 6.9288 (0.6); 6.9088 (0.6); 6.7030 (1.3); 6.5184 (2.6); 6.3338 (1.3); 4.5912 (3.2); 4.5763 (3.1); 4.1732 (0.9); 4.1545 (0.9); 4.1490 (1.1); 4.1304 (1.1); 3.9622 (1.0); 3.9406 (1.3); 3.9382 (1.0); 3.9165 (0.9); 3.1872 (0.5); 3.1640 (0.6); 3.1451 (0.6); 2.9825 (0.9); 2.9607 (0.6); 2.9399 (1.5); 2.9181 (1.2); 2.8436 (1.4); 2.8199 (1.3); 2.8010 (0.8); 2.7773 (0.7); 1.5385 (16.0); 0.0080 (0.9); -0.0002 (27.6); -0.0085 (0.8) I.2-76: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3883 (1.5); 8.3768 (2.9); 8.3657 (1.5); 7.6210 (5.6); 7.6159 (3.5); 7.5178 (8.9); 7.5163 (9.0); 7.4970 (16.0); 7.4620 (1.1); 7.4562 (1.6); 7.4514 (1.2); 7.4394 (4.2); 7.4352 (7.4); 7.4307 (8.3); 7.4169 (5.0); 7.4128 (6.0); 7.4003 (6.9); 7.3922 (2.1); 7.3818 (5.4); 7.3786 (4.9); 7.3601 (4.0); 7.2318 (9.1); 7.0467 (4.6); 6.9590 (2.6); 6.9532 (1.8); 6.9405 (2.6); 5.7530 (1.8); 4.5530 (6.1); 4.5497 (6.2); 4.5414 (6.1); 4.5381 (6.1); 4.4836 (0.6); 4.4707 (0.6); 4.0187 (2.1); 3.9944 (3.9); 3.9729 (3.1); 3.8856 (3.2); 3.8713 (3.3); 3.8613 (2.4); 3.8469 (2.4); 3.3091 (134.7); 3.2587 (2.3); 3.2433 (1.3); 3.2356 (1.2); 3.2216 (0.8); 2.7826 (2.3); 2.7592 (2.2); 2.7401 (4.4); 2.7167 (4.0); 2.6739 (2.8); 2.6692 (4.2); 2.6645 (7.1); 2.6472 (4.3); 2.6219 (2.4); 2.6047 (2.5); 2.5454 (1.6); 2.5227 (10.8); 2.5180 (15.8); 2.5094 (211.5); 2.5048 (459.9); 2.5002 (640.4); 2.4956 (457.2); 2.4910 (210.2); 2.3316 (2.7); 2.3270 (3.7); 2.3224 (2.7); 2.3179 (1.3); 2.0721 (1.0); 1.3578 (6.4); 0.8659 (0.7); 0.1461 (1.3); 0.0080 (10.2); -0.0002 (344.1); -0.0085 (10.9); -0.1497 (1.3) I.2-77: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3899 (1.4); 8.3787 (2.7); 8.3676 (1.4); 7.9616 (4.2); 7.7397 (2.1); 7.7369 (2.0); 7.7216 (2.0); 7.7190 (2.6); 7.7162 (2.6); 7.5366 (3.1); 7.5161 (13.3); 7.4970 (16.0); 7.4805 (0.8); 7.4624 (1.4); 7.4591 (1.7); 7.4434 (1.3); 7.4381 (1.1); 7.4189 (1.7); 7.4004 (7.5); 7.3819 (5.1); 7.3787 (5.5); 7.3602 (3.8); 7.3421 (3.4); 7.3344 (1.4); 7.3225 (2.6); 7.3160 (1.2); 7.3126 (0.8); 7.2940 (0.5); 7.1743 (2.8); 7.0348 (6.0); 6.8953 (2.9); 4.5556 (7.8); 4.5439 (7.7); 4.2285 (0.5); 4.2090 (0.6); 4.1039 (5.4); 4.0482 (2.3); 4.0265 (3.5); 4.0242 (4.0); 4.0027 (3.1); 3.9130 (3.2); 3.8985 (3.3); 3.8888 (2.4); 3.8744 (2.5); 3.6012 (0.5); 3.4936 (0.7); 3.3127 (0.8); 3.2955 (1.2); 3.2906 (1.3); 3.2810 (1.2); 3.2745 (2.0); 3.2587 (1.3); 3.2533 (1.1); 3.2364 (0.7); 2.7891 (2.1); 2.7658 (2.0); 2.7467 (4.2); 2.7234 (3.8); 2.6776 (4.4); 2.6696 (1.3); 2.6604 (4.2); 2.6351 (2.0); 2.6179 (1.9); 2.5231 (2.7); 2.5184 (3.9); 2.5097 (53.4); 2.5051 (116.3); 2.5005 (163.1); 2.4959 (116.3); 2.4914 (53.3); 2.3320 (0.7); 2.3273 (1.0); 2.3227 (0.7); 1.4582 (0.9); 1.4226 (0.5); 0.9357 (0.5); 0.9192 (1.1); 0.9094 (0.8); 0.8887 (1.1); 0.8855 (1.0); 0.8705 (2.2); 0.8673 (2.2); 0.8524 (1.6); 0.8492 (1.7); 0.0080 (3.0); -0.0002 (98.2); -0.0085 (2.9) I.2-78: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5184 (0.7); 7.4085 (1.4); 7.3981 (1.7); 7.3935 (2.6); 7.3850 (2.3); 7.3824 (2.1); 7.3700 (1.0); 7.3637 (0.7); 7.3488 (0.6); 7.2881 (0.6); 7.2765 (2.6); 7.2695 (2.1); 7.2596 (129.6); 7.2531 (4.0); 6.9956 (0.7); 6.9256 (0.8); 6.9220 (0.8); 6.9156 (1.0); 6.9062 (1.3); 6.9009 (1.0); 6.8948 (1.5); 6.8882 (1.2); 6.8739 (0.8); 4.5857 (4.1); 4.5709 (4.0); 4.0456 (0.7); 4.0272 (0.8); 4.0220 (1.1); 4.0037 (1.1); 3.9303 (1.3); 3.9089 (1.5); 3.8850 (0.9); 3.2560 (0.6); 3.2351 (0.8); 3.2144 (0.7); 2.9371 (1.1); 2.9164 (0.9); 2.8946 (1.8); 2.8739 (1.7); 2.7921 (1.8); 2.7686 (1.6); 2.7496 (1.0); 2.7260 (0.9); 1.5369 (16.0); 0.0079 (1.5); - 0.0002 (45.8); -0.0084 (1.4) I.2-79: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5562 (1.4); 7.5473 (10.2); 7.5415 (3.9); 7.5354 (10.5); 7.5299 (6.3); 7.5243 (11.0); 7.5184 (5.4); 7.5124 (10.4); 7.5035 (1.1); 7.3655 (14.8); 7.3449 (25.1); 7.3084 (0.8); 7.2886 (1.4); 7.2597 (361.7); 7.2414 (10.0); 7.2228 (8.3); 7.2198 (7.1); 7.2012 (5.5); 7.0815 (1.4); 7.0726 (11.2); 7.0668 (3.7); 7.0609 (2.2); 7.0551 (5.0); 7.0520 (13.5); 7.0496 (11.6); 7.0462 (4.1); 7.0406 (1.7); 7.0347 (3.5); 7.0289 (9.8); 7.0201 (0.8); 6.9957 (1.9); 5.8324 (2.3); 4.8656 (0.6); 4.8524 (0.7); 4.8306 (11.8); 4.8272 (11.3); 4.8170 (11.2); 4.8135 (10.9); 4.7921 (0.6); 4.7783 (0.6); 4.6906 (0.7); 4.1869 (5.7); 4.1683 (6.3); 4.1628 (7.0); 4.1442 (6.9); 3.9275 (6.7); 3.9059 (8.4); 3.9036 (6.8); 3.8819 (5.9); 3.1923 (1.1); 3.1706 (3.2); 3.1519 (3.5); 3.1495 (3.9); 3.1469 (3.7); 3.1283 (3.6); 3.1067 (1.5); 2.9666 (5.4); 2.9449 (4.1); 2.9241 (8.7); 2.9024 (7.6); 2.8179 (8.4); 2.7940 (7.6); 2.7754 (4.9); 2.7516 (4.4); 2.6512 (0.8); 1.9903 (0.9); 1.5446 (16.0); 1.2559 (1.2); 1.1636 (0.7); 0.0079 (4.8); -0.0002 (129.2); -0.0085 (4.0) I.2-80: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5187 (0.8); 7.5073 (1.3); 7.5018 (2.6); 7.4965 (1.5); 7.4228 (0.9); 7.4202 (1.0); 7.4177 (0.8); 7.4150 (0.8); 7.4021 (1.7); 7.3995 (1.8); 7.3970 (1.7); 7.3943 (1.5); 7.3884 (2.7); 7.3821 (2.9); 7.3657 (2.2); 7.3454 (3.3); 7.3390 (2.7); 7.3249 (1.4); 7.3178 (4.4); 7.2598 (150.3); 7.2536 (3.1); 7.2382 (1.4); 7.2320 (1.3); 6.9958 (0.8); 6.9344 (1.0); 6.9310 (1.0); 6.9147 (0.9); 6.9110 (0.9); 6.7062 (2.4); 6.5217 (4.8); 6.3371 (2.5); 6.0477 (0.6); 4.5531 (2.6); 4.5494 (2.6); 4.5381 (2.5); 4.5343 (2.6); 4.1823 (1.5); 4.1637 (1.6); 4.1581 (1.9); 4.1395 (1.9); 3.9776 (1.8); 3.9560 (2.2); 3.9534 (1.7); 3.9319 (1.5); 3.2103 (0.8); 3.1892 (1.0); 3.1681 (0.9); 2.9825 (1.4); 2.9607 (1.1); 2.9399 (2.5); 2.9181 (2.3); 2.8615 (2.5); 2.8378 (2.2); 2.8190 (1.3); 2.7952 (1.1); 1.5440 (16.0); 0.0080 (1.6); -0.0002 (52.8); -0.0085 (1.4) I.2-81: 1H-NMR (400.0 MHz, CDCl3): δ= 7.4144 (0.7); 7.4091 (0.7); 7.3598 (0.6); 7.3390 (0.7); 7.2597 (66.6); 4.5411 (0.8); 4.5259 (0.8); 2.8763 (0.5); 1.5380 (16.0); 0.0079 (0.7); -0.0002 (23.2); -0.0085 (0.6) I.2-82: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6770 (2.8); 7.9630 (5.1); 7.7535 (2.8); 7.7358 (3.2); 7.5463 (2.8); 7.5264 (4.9); 7.5079 (7.4); 7.4879 (7.1); 7.4860 (7.4); 7.4014 (16.0); 7.3812 (4.5); 7.3747 (2.6); 7.3465 (3.6); 7.3274 (2.9); 7.1767 (3.4); 7.0370 (7.1); 6.8975 (3.5); 4.3778 (9.0); 4.3633 (8.8); 4.1085 (2.8); 4.0843 (4.6); 4.0630 (3.9); 3.9656 (3.7); 3.9510 (3.9); 3.9413 (2.8); 3.9268 (2.9); 3.4127 (0.9); 3.3904 (1.4); 3.3748 (2.2); 3.3602 (2.3); 3.3106 (277.9); 2.8517 (2.9); 2.8286 (2.8); 2.8094 (5.0); 2.7861 (4.6); 2.7215 (5.1); 2.7044 (4.7); 2.6790 (3.2); 2.6698 (2.0); 2.6619 (3.2); 2.5231 (6.0); 2.5184 (7.9); 2.5097 (117.9); 2.5052 (257.5); 2.5006 (358.3); 2.4959 (249.4); 2.4914 (110.0); 2.3273 (2.2); 1.2356 (1.9); -0.0002 (24.8) I.2-83: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7245 (8.8); 7.9774 (9.5); 7.9738 (9.6); 7.5796 (10.4); 7.5741 (4.2); 7.5677 (11.1); 7.5623 (6.9); 7.5566 (12.3); 7.5506 (4.6); 7.5447 (11.7); 7.5185 (4.5); 7.3104 (3.1); 7.2979 (3.5); 7.2597 (772.4); 7.1640 (3.8); 7.0913 (12.3); 7.0855 (4.3); 7.0706 (14.4); 7.0683 (13.4); 7.0533 (4.0); 7.0477 (11.4); 6.9956 (4.2); 4.7737 (12.1); 4.7625 (12.4); 4.2270 (6.0); 4.2086 (6.6); 4.2028 (7.7); 4.1845 (8.0); 4.0259 (7.5); 4.0044 (9.0); 4.0019 (7.6); 3.9804 (6.5); 3.4163 (1.5); 3.3949 (3.9); 3.3741 (4.4); 3.3533 (3.8); 3.3313 (1.6); 3.0471 (5.1); 3.0256 (4.7); 3.0046 (9.5); 2.9832 (8.7); 2.9231 (9.8); 2.8994 (9.2); 2.8806 (4.9); 2.8569 (4.3); 1.5508 (16.0); 1.4172 (1.4); 0.0080 (10.0); -0.0002 (272.0); -0.0084 (12.2) I.2-84: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6670 (6.0); 7.6848 (8.8); 7.6726 (9.9); 7.6624 (10.6); 7.6498 (9.4); 7.6200 (11.7); 7.6154 (11.5); 7.4427 (4.5); 7.4222 (9.3); 7.4176 (8.8); 7.3871 (12.7); 7.3663 (5.9); 7.2337 (9.2); 7.2116 (15.8); 7.1898 (7.8); 4.3586 (16.0); 4.3447 (15.5); 4.0406 (3.8); 4.0178 (7.9); 3.9949 (5.6); 3.9102 (5.4); 3.8949 (6.2); 3.8864 (4.4); 3.8705 (4.1); 3.3094 (372.2); 2.7966 (3.2); 2.7728 (3.2); 2.7541 (7.0); 2.7310 (6.4); 2.6919 (7.6); 2.6739 (9.8); 2.6490 (3.6); 2.6317 (3.4); 2.5004 (645.8); 2.3280 (3.9); -0.0002 (41.5) I.2-85: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6954 (4.1); 7.7513 (1.1); 7.6844 (6.0); 7.6615 (7.5); 7.6486 (6.2); 7.5072 (4.5); 7.4853 (6.2); 7.4563 (1.8); 7.3986 (16.0); 7.3806 (4.8); 7.3420 (3.1); 7.2340 (6.0); 7.2125 (9.9); 7.1903 (5.3); 4.3726 (10.6); 4.3586 (10.4); 4.2850 (2.0); 4.2690 (2.1); 4.0558 (2.5); 4.0310 (5.4); 4.0100 (3.6); 3.9167 (3.8); 3.9028 (4.2); 3.8791 (2.6); 3.3101 (294.1); 2.8094 (2.6); 2.7866 (2.8); 2.7667 (4.4); 2.7448 (4.5); 2.6857 (5.9); 2.6689 (9.1); 2.6434 (4.6); 2.6249 (5.1); 2.5005 (680.7); 2.3274 (4.4); 0.8529 (1.8); -0.0002 (43.1) I.2-86: 1H-NMR (400.0 MHz, CDCl3): δ= 7.3537 (2.7); 7.3526 (2.7); 7.3332 (4.7); 7.2937 (0.7); 7.2893 (0.8); 7.2749 (0.9); 7.2730 (0.9); 7.2705 (1.3); 7.2688 (1.4); 7.2604 (35.0); 7.2560 (1.8); 7.2502 (1.3); 7.2406 (1.6); 7.2365 (1.1); 7.2274 (1.9); 7.2088 (1.5); 7.2058 (1.4); 7.1872 (1.1); 6.9960 (1.0); 6.9928 (1.0); 6.9769 (1.3); 6.9738 (1.4); 6.9578 (0.7); 6.9546 (0.8); 6.9465 (1.3); 6.9437 (1.1); 6.9259 (1.2); 6.9232 (1.0); 4.8186 (2.7); 4.8050 (2.6); 4.0121 (1.0); 3.9948 (1.0); 3.9876 (1.4); 3.9703 (1.5); 3.8806 (1.4); 3.8594 (1.6); 3.8561 (1.2); 3.8349 (1.1); 3.7666 (16.0); 3.2246 (0.7); 3.2216 (0.6); 3.2043 (0.5); 2.9299 (1.0); 2.9099 (0.9); 2.8876 (1.6); 2.8677 (1.4); 2.7694 (1.6); 2.7458 (1.5); 2.7271 (1.0); 2.7035 (0.9); 1.5731 (0.5); -0.0002 (12.1) I.2-87: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5190 (1.1); 7.4036 (2.4); 7.3887 (2.7); 7.3806 (4.6); 7.3657 (5.2); 7.3598 (17.0); 7.3440 (5.0); 7.3394 (23.8); 7.3073 (0.8); 7.2885 (0.7); 7.2844 (0.6); 7.2602 (191.0); 7.2365 (10.7); 7.2179 (8.7); 7.2148 (7.8); 7.1962 (5.8); 6.9962 (1.1); 6.9323 (2.0); 6.9295 (1.4); 6.9253 (2.9); 6.9225 (3.5); 6.9168 (3.8); 6.9106 (5.5); 6.9052 (6.1); 6.9033 (6.0); 6.8956 (4.0); 6.8899 (7.9); 6.8852 (5.2); 6.8839 (5.5); 6.8785 (1.5); 6.8687 (3.8); 6.8622 (2.5); 5.8333 (2.6); 4.8222 (16.0); 4.8086 (15.5); 4.7866 (0.7); 4.7722 (0.5); 4.0547 (3.5); 4.0353 (4.1); 4.0308 (5.3); 4.0126 (5.3); 3.9183 (5.5); 3.8965 (7.2); 3.8730 (4.3); 3.2587 (1.2); 3.2376 (3.2); 3.2191 (3.4); 3.2166 (4.1); 3.2141 (3.7); 3.1958 (3.4); 3.1747 (1.5); 2.9435 (5.4); 2.9226 (4.6); 2.9009 (8.3); 2.8800 (7.6); 2.7736 (8.0); 2.7499 (7.5); 2.7310 (5.2); 2.7073 (4.6); 2.0419 (0.7); 1.5554 (2.4); 1.2579 (0.9); 0.0080 (2.4); -0.0002 (71.8); -0.0085 (3.0) I.2-88: 1H-NMR (400.0 MHz, CDCl3): δ= 7.7456 (0.9); 7.3973 (0.6); 7.3914 (0.5); 7.2854 (0.9); 7.2782 (0.6); 7.2743 (0.8); 7.2719 (0.8); 7.2680 (0.9); 7.2594 (69.6); 6.6341 (0.7); 4.5960 (1.4); 4.5812 (1.4); 3.9768 (0.6); 2.9520 (0.6); 2.9302 (0.6); 2.8574 (0.6); 2.8336 (0.5); 1.5343 (16.0); 0.0080 (0.8); -0.0002 (24.9); -0.0085 (0.7) I.2-89: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7265 (5.0); 8.7240 (4.9); 7.9801 (5.3); 7.9788 (5.5); 7.9752 (5.4); 7.9740 (5.0); 7.5877 (1.4); 7.5800 (13.4); 7.5745 (4.2); 7.5629 (4.7); 7.5573 (16.0); 7.5496 (1.7); 7.5205 (0.6); 7.3551 (2.0); 7.3475 (17.1); 7.3419 (4.7); 7.3303 (4.4); 7.3248 (13.5); 7.3171 (1.3); 7.2729 (0.8); 7.2713 (1.0); 7.2697 (1.2); 7.2689 (1.3); 7.2681 (1.5); 7.2616 (102.2); 7.2113 (1.0); 7.1808 (1.8); 6.9976 (0.6); 4.7709 (7.1); 4.7599 (6.9); 4.2214 (4.0); 4.2029 (4.2); 4.1973 (4.9); 4.1788 (5.1); 4.0277 (4.7); 4.0062 (5.8); 4.0036 (4.5); 3.9821 (4.0); 3.4170 (0.8); 3.3953 (2.2); 3.3767 (2.3); 3.3744 (2.5); 3.3720 (2.4); 3.3534 (2.3); 3.3504 (1.4); 3.3318 (0.9); 3.0540 (3.6); 3.0323 (3.0); 3.0113 (6.3); 2.9897 (5.9); 2.9253 (6.4); 2.9017 (5.9); 2.8827 (3.4); 2.8590 (3.1); 2.0448 (0.8); 1.5796 (5.8); 1.2591 (0.6); 0.0080 (1.4); -0.0002 (43.8); -0.0085 (1.3) I.2-90: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7297 (8.1); 8.7276 (9.7); 8.7250 (9.5); 7.9699 (10.6); 7.9685 (10.9); 7.9650 (10.5); 7.9636 (10.0); 7.5226 (1.0); 7.2781 (0.5); 7.2765 (0.6); 7.2757 (0.6); 7.2749 (0.7); 7.2741 (0.7); 7.2733 (0.9); 7.2725 (1.0); 7.2709 (1.6); 7.2701 (1.9); 7.2693 (2.1); 7.2685 (2.7); 7.2677 (3.2); 7.2637 (189.6); 7.2604 (3.8); 7.2595 (2.4); 7.2587 (1.5); 7.2579 (1.0); 7.2571 (0.7); 7.2562 (0.6); 7.2554 (0.6); 7.2547 (0.5); 7.2138 (1.4); 7.1117 (3.2); 6.9996 (1.1); 4.7481 (13.4); 4.7371 (13.2); 4.7042 (1.1); 4.6833 (3.1); 4.6604 (5.3); 4.6405 (2.9); 4.6167 (1.2); 3.7788 (4.2); 3.7605 (5.0); 3.7546 (10.0); 3.7363 (10.5); 3.7223 (10.3); 3.7009 (11.7); 3.6983 (6.0); 3.6766 (5.0); 3.2646 (1.8); 3.2461 (2.3); 3.2434 (4.2); 3.2407 (2.8); 3.2250 (4.0); 3.2222 (5.2); 3.2193 (4.8); 3.2010 (4.3); 3.1982 (2.8); 3.1797 (1.9); 2.8260 (5.9); 2.8049 (5.3); 2.7840 (12.2); 2.7629 (11.5); 2.7188 (13.0); 2.6947 (12.2); 2.6768 (6.2); 2.6527 (5.6); 2.2580 (0.6); 2.2341 (1.9); 2.2293 (2.6); 2.2082 (3.6); 2.2050 (6.2); 2.2021 (4.1); 2.1807 (7.4); 2.1734 (5.0); 2.1600 (6.6); 2.1562 (7.4); 2.1537 (9.2); 2.1462 (6.2); 2.1428 (5.2); 2.1396 (6.5); 2.1306 (5.7); 2.1264 (6.0); 2.1180 (2.6); 2.1140 (2.1); 2.1060 (1.2); 2.1016 (0.9); 1.7417 (2.0); 1.7359 (1.4); 1.7338 (1.4); 1.7246 (6.4); 1.7170 (3.9); 1.7124 (5.5); 1.7008 (10.1); 1.6922 (2.6); 1.6876 (6.0); 1.6769 (4.8); 1.6645 (1.4); 1.6621 (1.7); 1.6033 (16.0); 1.2560 (0.7); 0.0080 (2.4); 0.0065 (0.8); 0.0057 (0.9); 0.0049 (1.0); 0.0041 (1.2); 0.0024 (3.0); -0.0002 (81.4); -0.0058 (0.6); -0.0085 (2.1); -0.0500 (0.6) I.2-91: 1H-NMR (400.0 MHz, CDCl3): δ= 8.5555 (4.9); 8.5435 (4.9); 7.8965 (4.0); 7.8761 (4.5); 7.8442 (8.2); 7.7242 (3.2); 7.7198 (3.1); 7.7050 (6.3); 7.7007 (6.0); 7.6858 (3.8); 7.6814 (3.5); 7.5194 (0.9); 7.5081 (2.9); 7.4886 (6.4); 7.4682 (4.1); 7.4173 (5.9); 7.3978 (3.6); 7.2836 (7.0); 7.2606 (132.3); 7.2493 (5.0); 7.2428 (4.1); 7.2303 (3.3); 7.1492 (2.7); 6.9966 (0.7); 4.6194 (16.0); 4.6079 (15.6); 4.2470 (4.8); 4.2283 (5.7); 4.2230 (6.3); 4.2044 (6.2); 4.0562 (5.8); 4.0345 (8.0); 4.0107 (4.8); 3.3810 (1.1); 3.3592 (3.2); 3.3382 (4.0); 3.3174 (3.4); 3.2957 (1.3); 3.0652 (4.5); 3.0435 (3.8); 3.0224 (7.5); 3.0007 (6.8); 2.9155 (7.4); 2.8919 (6.8); 2.8726 (4.3); 2.8490 (3.9); 1.6454 (2.8); 1.2522 (1.6); -0.0002 (47.6); -0.0084 (2.0) I.2-92: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7249 (3.9); 8.7101 (6.5); 8.6975 (3.3); 8.1750 (12.6); 7.8313 (6.1); 7.8111 (7.0); 7.6398 (4.9); 7.6200 (9.7); 7.5998 (5.2); 7.4993 (8.4); 7.4799 (6.2); 7.3741 (2.0); 7.3675 (2.4); 7.3496 (4.7); 7.3354 (5.1); 7.3294 (3.9); 7.3226 (4.0); 7.3096 (2.1); 7.2177 (2.3); 7.1982 (6.2); 7.1860 (11.2); 7.1778 (10.1); 7.1713 (11.0); 4.3960 (16.0); 4.3817 (15.5); 4.1073 (5.6); 4.0831 (9.5); 4.0616 (8.1); 3.9666 (7.8); 3.9516 (8.4); 3.9421 (5.7); 3.9274 (6.0); 3.3645 (7.3); 3.3140 (679.5); 3.2647 (3.5); 2.8397 (5.5); 2.8165 (5.5); 2.7973 (10.3); 2.7741 (9.5); 2.7161 (10.3); 2.6985 (9.7); 2.6738 (11.4); 2.6698 (9.6); 2.6653 (6.9); 2.6561 (7.0); 2.5518 (9.6); 2.5470 (7.9); 2.5229 (55.5); 2.5096 (562.0); 2.5052 (1074.2); 2.5006 (1387.8); 2.4961 (970.0); 2.4917 (441.8); 2.4608 (8.4); 2.4003 (1.5); 2.3566 (1.9); 2.3320 (6.2); 2.3274 (8.1); 2.3230 (5.6); 2.0726 (1.2); -0.0002 (33.3) I.2-93: 1H-NMR (400.0 MHz, CDCl3): δ= 7.3630 (1.8); 7.3568 (1.9); 7.3193 (1.9); 7.3082 (0.7); 7.3039 (0.9); 7.2980 (3.1); 7.2894 (0.9); 7.2875 (0.9); 7.2850 (1.1); 7.2833 (1.1); 7.2686 (2.2); 7.2644 (2.8); 7.2604 (29.4); 7.2490 (1.7); 7.2448 (1.2); 7.2352 (1.6); 7.2289 (1.4); 7.2139 (1.0); 7.2077 (0.9); 7.0094 (0.9); 7.0063 (1.0); 6.9904 (1.4); 6.9873 (1.5); 6.9713 (0.7); 6.9681 (0.8); 6.9615 (1.4); 6.9587 (1.2); 6.9408 (1.2); 6.9380 (1.0); 4.5356 (3.2); 4.5205 (3.1); 4.0157 (0.9); 3.9995 (1.0); 3.9910 (1.4); 3.9748 (1.5); 3.9067 (1.4); 3.8860 (1.6); 3.8820 (1.1); 3.8613 (1.0); 3.7866 (16.0); 3.2663 (0.7); 2.9037 (0.7); 2.8850 (0.6); 2.8614 (1.8); 2.8427 (1.6); 2.8139 (1.7); 2.7904 (1.6); 2.7716 (0.7); 2.7480 (0.6); -0.0002 (10.5) I.2-94: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7615 (0.5); 8.7241 (11.8); 7.9738 (12.4); 7.9697 (12.6); 7.9421 (0.7); 7.8895 (0.5); 7.5192 (2.2); 7.4402 (3.3); 7.4316 (1.2); 7.4252 (4.5); 7.4170 (6.6); 7.4024 (6.4); 7.3961 (4.6); 7.3813 (4.5); 7.3113 (0.6); 7.2892 (0.8); 7.2604 (401.7); 7.2101 (0.7); 7.1587 (4.1); 6.9963 (2.1); 6.9491 (2.8); 6.9395 (6.5); 6.9371 (6.2); 6.9311 (5.2); 6.9271 (3.7); 6.9221 (8.8); 6.9202 (9.6); 6.9159 (7.0); 6.9103 (10.2); 6.9026 (6.8); 6.8956 (1.8); 6.8894 (5.7); 6.8827 (3.4); 5.2985 (0.7); 4.7703 (16.0); 4.7596 (15.7); 4.3860 (0.7); 4.2517 (1.3); 4.1133 (4.9); 4.0941 (5.6); 4.0893 (7.8); 4.0713 (8.0); 4.0138 (8.7); 3.9923 (10.5); 3.9686 (6.0); 3.6197 (0.6); 3.4830 (1.8); 3.4622 (4.7); 3.4414 (5.8); 3.4206 (4.8); 3.3997 (1.9); 3.0187 (7.3); 2.9979 (6.6); 2.9761 (12.9); 2.9553 (12.2); 2.8787 (12.8); 2.8552 (12.2); 2.8361 (7.3); 2.8126 (6.5); 2.1351 (1.0); 1.7417 (0.7); 1.4796 (0.8); 1.2449 (0.7); 0.0695 (0.5); 0.0080 (4.4); -0.0002 (146.2); -0.0085 (4.2); -0.1498 (0.6) I.2-95: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7259 (10.0); 7.9786 (10.9); 7.9751 (10.9); 7.7773 (14.9); 7.7748 (16.0); 7.7606 (6.6); 7.7579 (7.2); 7.7551 (5.6); 7.5190 (2.8); 7.4910 (3.5); 7.4714 (6.6); 7.4494 (4.4); 7.3264 (7.1); 7.3071 (5.9); 7.2602 (482.4); 7.1850 (4.5); 6.9961 (2.8); 6.7866 (6.1); 6.6456 (12.5); 6.5047 (6.2); 4.7768 (13.4); 4.7660 (13.6); 4.2703 (6.8); 4.2519 (7.7); 4.2461 (9.6); 4.2278 (9.0); 4.0887 (8.4); 4.0672 (10.4); 4.0646 (8.2); 4.0431 (7.0); 3.4327 (1.5); 3.4110 (4.1); 3.3901 (4.8); 3.3877 (4.7); 3.3694 (4.3); 3.3479 (1.9); 3.0935 (0.8); 3.0796 (6.4); 3.0582 (5.6); 3.0369 (11.0); 3.0155 (10.2); 2.9469 (11.0); 2.9234 (10.2); 2.9042 (6.0); 2.8806 (5.5); 1.6381 (2.8); 1.3637 (1.3); 0.0696 (1.0); 0.0080 (5.4); -0.0002 (171.9); -0.0085 (6.7); -0.1496 (0.7) I.2-96: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7150 (0.8); 8.7001 (1.6); 8.6854 (0.7); 8.3351 (2.9); 8.3303 (2.9); 8.3288 (2.7); 7.7657 (2.1); 7.7593 (2.1); 7.7451 (2.5); 7.7388 (2.4); 7.5289 (5.8); 7.5241 (1.9); 7.5124 (2.1); 7.5075 (6.7); 7.4993 (4.1); 7.4977 (3.9); 7.4787 (3.4); 7.4772 (3.3); 7.1799 (4.7); 7.1594 (4.2); 4.3366 (4.8); 4.3220 (4.7); 4.0046 (1.5); 3.9827 (2.3); 3.9802 (2.7); 3.9586 (2.1); 3.8763 (2.3); 3.8608 (2.4); 3.8519 (1.6); 3.8365 (1.7); 3.3701 (0.8); 3.3204 (93.2); 3.2801 (1.3); 3.2703 (1.1); 3.2635 (1.0); 2.7609 (1.3); 2.7377 (1.2); 2.7187 (3.1); 2.6954 (2.8); 2.6709 (3.7); 2.6653 (0.9); 2.6525 (2.8); 2.6288 (1.1); 2.6103 (1.2); 2.5552 (0.9); 2.5506 (1.2); 2.5456 (1.2); 2.5234 (3.9); 2.5188 (5.3); 2.5101 (56.0); 2.5055 (120.0); 2.5009 (166.7); 2.4962 (116.4); 2.4916 (51.5); 2.4552 (1.0); 2.4507 (1.5); 2.4459 (1.2); 2.4416 (0.7); 2.3323 (0.8); 2.3277 (1.1); 2.3230 (0.9); 2.2748 (16.0); 2.0734 (0.7); 0.1265 (1.3); 0.0081 (1.0); -0.0002 (34.2); -0.0086 (1.0) I.2-97: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7241 (7.8); 8.7215 (7.7); 7.9759 (8.5); 7.9745 (8.7); 7.9710 (8.6); 7.9697 (8.1); 7.6151 (1.9); 7.6134 (2.3); 7.6108 (11.9); 7.6079 (14.1); 7.6027 (3.7); 7.5937 (4.5); 7.5913 (8.1); 7.5888 (16.0); 7.5861 (13.9); 7.5804 (1.6); 7.5202 (0.9); 7.4045 (1.9); 7.3995 (11.2); 7.3978 (4.8); 7.3943 (3.7); 7.3863 (2.4); 7.3809 (14.2); 7.3783 (10.3); 7.3729 (1.7); 7.3641 (4.1); 7.3614 (4.4); 7.3594 (11.3); 7.3539 (1.4); 7.2733 (0.5); 7.2725 (0.6); 7.2717 (0.7); 7.2709 (0.8); 7.2701 (0.9); 7.2693 (1.0); 7.2685 (1.3); 7.2677 (1.6); 7.2669 (1.8); 7.2613 (162.9); 7.2571 (1.8); 7.2563 (1.2); 7.2555 (0.9); 7.2547 (0.6); 7.2538 (0.6); 7.2531 (0.6); 7.2112 (1.3); 7.1923 (5.4); 7.1895 (8.8); 7.1867 (6.1); 7.1745 (5.0); 7.1728 (5.2); 7.1710 (10.2); 7.1692 (4.8); 7.1673 (3.6); 7.1552 (2.7); 7.1524 (4.5); 7.1496 (2.3); 6.9972 (0.9); 4.7735 (11.1); 4.7625 (11.0); 4.2503 (6.7); 4.2315 (7.2); 4.2260 (8.5); 4.2073 (8.8); 4.0596 (8.2); 4.0381 (9.7); 4.0353 (7.6); 4.0139 (6.9); 3.4200 (1.4); 3.4011 (1.9); 3.3982 (3.6); 3.3793 (3.7); 3.3773 (4.0); 3.3750 (4.1); 3.3561 (3.8); 3.3533 (2.3); 3.3344 (1.6); 3.0629 (6.2); 3.0410 (5.3); 3.0204 (10.5); 2.9986 (9.8); 2.9248 (10.5); 2.9012 (9.9); 2.8823 (6.0); 2.8588 (5.4); 1.5844 (8.5); 0.0080 (2.0); 0.0056 (0.6); 0.0048 (0.8); -0.0002 (68.9); - 0.0085 (1.8) I.2-98: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7224 (1.4); 8.7200 (1.4); 7.9635 (1.5); 7.9596 (1.5); 7.3080 (2.2); 7.3035 (1.3); 7.2907 (1.9); 7.2882 (2.6); 7.2842 (1.5); 7.2728 (1.3); 7.2684 (0.9); 7.2604 (36.2); 7.2001 (0.5); 7.0163 (0.8); 7.0132 (1.0); 6.9969 (1.2); 6.9942 (1.8); 6.9755 (1.9); 6.9544 (1.2); 6.9511 (0.9); 4.7744 (2.0); 4.7631 (1.9); 4.0791 (0.9); 4.0612 (1.0); 4.0548 (1.5); 4.0368 (1.5); 3.9874 (1.5); 3.9662 (1.7); 3.9630 (1.1); 3.9419 (1.0); 3.8345 (16.0); 3.4461 (0.6); 3.4280 (0.6); 3.4254 (0.7); 3.4227 (0.6); 3.4047 (0.6); 3.0108 (1.0); 2.9903 (0.9); 2.9687 (1.6); 2.9481 (1.5); 2.8635 (1.6); 2.8400 (1.6); 2.8213 (1.0); 2.7978 (0.9); 1.5634 (6.0); - 0.0002 (13.4) I.2-99: 1H-NMR (400.0 MHz, CDCl3): δ= 8.3042 (3.7); 8.2988 (3.7); 7.6318 (2.8); 7.6254 (2.8); 7.6113 (3.1); 7.6050 (3.1); 7.5214 (0.6); 7.3220 (4.7); 7.3015 (4.3); 7.2625 (107.4); 7.2126 (0.8); 6.9985 (0.6); 6.0973 (1.0); 4.5131 (1.2); 4.4985 (1.1); 4.4903 (1.9); 4.4757 (3.7); 4.4699 (3.0); 4.4607 (3.6); 4.4479 (4.4); 4.4326 (3.5); 4.4099 (1.0); 4.3950 (1.0); 3.6439 (2.1); 3.6262 (2.3); 3.6196 (3.2); 3.6019 (3.2); 3.5262 (3.1); 3.5047 (3.8); 3.5021 (2.8); 3.4804 (2.4); 3.0792 (0.7); 3.0613 (0.9); 3.0581 (1.5); 3.0554 (1.1); 3.0404 (1.5); 3.0373 (2.0); 3.0342 (1.8); 3.0164 (1.6); 3.0132 (1.1); 2.9953 (0.7); 2.7072 (1.5); 2.6865 (1.4); 2.6657 (4.7); 2.6449 (4.4); 2.6322 (4.8); 2.6082 (4.3); 2.5906 (1.6); 2.5666 (1.4); 1.8484 (1.5); 1.8371 (1.6); 1.8189 (1.8); 1.7982 (1.0); 1.6958 (1.9); 1.6887 (2.0); 1.6812 (1.6); 1.6720 (1.9); 1.6492 (1.0); 1.6403 (1.3); 1.6283 (1.0); 1.6216 (1.8); 1.6173 (2.0); 1.6087 (2.0); 1.6013 (2.6); 1.5885 (16.0); 1.5727 (1.8); 1.5580 (1.3); 1.5487 (1.2); 1.5369 (1.0); 1.5279 (1.1); 1.5193 (1.0); 1.5071 (1.0); 1.4987 (1.1); 1.4887 (1.0); 1.4850 (0.9); 1.4782 (1.0); 1.4680 (0.9); 1.4491 (0.7); 0.0080 (1.2); -0.0002 (43.3); -0.0085 (1.5) I.2-100: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6849 (3.4); 7.6210 (13.3); 7.6160 (11.7); 7.5991 (6.6); 7.5932 (5.7); 7.5798 (4.3); 7.5408 (2.6); 7.4723 (4.5); 7.4496 (8.1); 7.4433 (5.6); 7.4381 (9.7); 7.4224 (9.9); 7.4182 (16.0); 7.3982 (3.9); 7.3920 (9.5); 7.3713 (4.2); 7.2331 (12.6); 7.0480 (6.3); 6.9663 (3.0); 6.9440 (3.3); 4.3593 (8.6); 4.3446 (8.1); 4.0656 (3.6); 4.0407 (5.4); 4.0196 (4.0); 3.9270 (3.6); 3.9125 (4.1); 3.9029 (3.0); 3.8874 (2.9); 3.8636 (8.2); 3.3802 (15.6); 2.8313 (2.4); 2.8082 (2.6); 2.7890 (5.4); 2.7656 (4.7); 2.7136 (4.9); 2.6962 (4.8); 2.6701 (4.8); 2.6537 (2.3); 2.5232 (8.4); 2.5184 (12.7); 2.5097 (204.1); 2.5051 (454.2); 2.5005 (639.7); 2.4959 (456.1); 2.4913 (207.7); 2.3271 (3.4); 1.4615 (3.0); 0.9137 (3.3); -0.0002 (70.9) I.2-101: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5223 (0.5); 7.4041 (0.8); 7.3936 (4.2); 7.3894 (3.7); 7.3885 (3.6); 7.3860 (4.6); 7.3840 (2.7); 7.3815 (6.1); 7.3787 (4.6); 7.3775 (4.8); 7.3745 (4.7); 7.3705 (6.2); 7.3660 (5.0); 7.3617 (1.2); 7.3565 (0.6); 7.3546 (0.7); 7.2755 (2.0); 7.2732 (1.8); 7.2715 (1.2); 7.2706 (1.4); 7.2698 (1.5); 7.2690 (1.7); 7.2682 (2.0); 7.2635 (96.3); 7.2609 (3.4); 7.2601 (2.4); 7.2591 (2.1); 7.2568 (6.9); 7.2549 (8.1); 7.2510 (6.6); 7.2487 (6.1); 7.2457 (0.9); 7.2412 (13.6); 7.2299 (0.8); 7.2135 (0.6); 6.0633 (1.5); 4.5529 (16.0); 4.5380 (15.5); 4.5085 (0.8); 4.4878 (2.9); 4.4675 (3.8); 4.4474 (2.3); 3.9589 (0.6); 3.6353 (3.4); 3.6174 (3.7); 3.6110 (4.8); 3.5931 (5.0); 3.5063 (5.0); 3.4848 (6.0); 3.4822 (4.3); 3.4605 (3.8); 3.0632 (1.1); 3.0452 (1.4); 3.0420 (2.4); 3.0392 (1.6); 3.0241 (2.3); 3.0210 (3.0); 3.0179 (2.7); 3.0027 (1.4); 3.0000 (2.5); 2.9968 (1.6); 2.9788 (1.2); 2.7195 (3.2); 2.6987 (2.8); 2.6779 (7.4); 2.6570 (6.8); 2.6233 (7.5); 2.5992 (6.9); 2.5817 (3.3); 2.5576 (2.9); 1.8575 (0.7); 1.8545 (0.8); 1.8385 (1.7); 1.8326 (2.3); 1.8293 (2.3); 1.8230 (2.0); 1.8180 (2.0); 1.8144 (2.2); 1.8092 (2.5); 1.8028 (1.9); 1.7994 (2.0); 1.7863 (1.3); 1.7835 (1.1); 1.7187 (0.6); 1.6992 (1.7); 1.6941 (1.9); 1.6829 (3.1); 1.6784 (3.6); 1.6707 (3.0); 1.6654 (2.7); 1.6608 (3.4); 1.6559 (2.6); 1.6468 (1.2); 1.6397 (1.8); 1.6283 (2.1); 1.6182 (1.4); 1.6098 (2.1); 1.6043 (2.7); 1.5954 (2.6); 1.5891 (2.9); 1.5852 (2.7); 1.5786 (2.3); 1.5755 (2.5); 1.5677 (3.1); 1.5624 (2.2); 1.5598 (2.1); 1.5511 (1.9); 1.5379 (1.6); 1.5286 (1.1); 1.5210 (1.5); 1.5151 (1.4); 1.5119 (1.3); 1.4999 (1.4); 1.4945 (1.5); 1.4813 (1.3); 1.4743 (1.4); 1.4629 (1.2); 1.4597 (1.1); 1.4441 (1.0); 0.0079 (1.0); 0.0021 (1.3); -0.0002 (38.2); -0.0028 (1.8); -0.0044 (0.7); -0.0053 (0.5); -0.0085 (1.2) I.2-102: 1H-NMR (400.0 MHz, CDCl3): δ= 8.5504 (4.5); 8.5480 (5.2); 8.5466 (5.2); 8.5442 (4.5); 8.5382 (4.6); 8.5359 (5.1); 7.7139 (3.7); 7.7095 (3.6); 7.6947 (7.0); 7.6903 (6.7); 7.6755 (4.3); 7.6711 (4.0); 7.4314 (2.3); 7.4223 (1.1); 7.4167 (3.2); 7.4083 (4.6); 7.3936 (4.5); 7.3876 (3.2); 7.3727 (2.9); 7.2742 (8.5); 7.2627 (74.1); 7.2546 (7.8); 7.2384 (4.0); 7.2371 (3.9); 7.2359 (3.8); 7.2320 (3.8); 7.2196 (3.4); 7.2184 (3.1); 7.1258 (2.8); 6.9380 (2.2); 6.9355 (1.5); 6.9309 (3.5); 6.9284 (4.6); 6.9255 (4.3); 6.9195 (4.5); 6.9160 (3.3); 6.9110 (6.5); 6.9090 (6.8); 6.9043 (5.3); 6.8986 (7.1); 6.8914 (5.3); 6.8844 (1.4); 6.8779 (3.6); 6.8712 (2.2); 4.6075 (16.0); 4.5958 (15.2); 4.0851 (3.4); 4.0653 (4.3); 4.0612 (5.5); 4.0427 (5.4); 3.9775 (5.9); 3.9555 (7.6); 3.9322 (4.1); 3.4254 (1.3); 3.4041 (3.4); 3.3832 (4.3); 3.3624 (3.4); 3.3411 (1.3); 2.9958 (5.1); 2.9746 (4.6); 2.9532 (8.1); 2.9321 (7.6); 2.8351 (8.0); 2.8116 (7.6); 2.7925 (4.9); 2.7690 (4.4); 1.7272 (0.7); 1.2562 (1.1); 0.0080 (1.6); -0.0002 (29.2); -0.0085 (0.9) I.2-103: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7336 (15.9); 8.7213 (16.0); 7.5214 (0.8); 7.2706 (1.3); 7.2689 (1.7); 7.2626 (151.3); 7.2584 (2.6); 7.2568 (1.1); 7.2559 (0.8); 7.2551 (0.8); 7.2543 (0.6); 7.2535 (0.6); 7.2527 (0.6); 7.2495 (4.5); 7.2479 (6.3); 7.2373 (2.1); 7.2355 (3.1); 7.2127 (1.2); 6.9985 (0.9); 6.8999 (1.0); 4.7451 (3.6); 4.7415 (3.6); 4.7336 (3.8); 4.7300 (3.7); 4.7012 (0.7); 4.6815 (1.4); 4.6576 (2.3); 4.6377 (1.2); 4.6138 (0.5); 3.7889 (2.0); 3.7705 (2.4); 3.7647 (3.9); 3.7501 (1.1); 3.7462 (4.2); 3.7160 (4.1); 3.6943 (4.7); 3.6701 (2.4); 3.2455 (0.7); 3.2241 (1.7); 3.2056 (1.7); 3.2029 (2.0); 3.2001 (1.9); 3.1816 (1.8); 3.1600 (0.8); 2.8395 (2.5); 2.8182 (2.2); 2.7975 (4.6); 2.7762 (4.3); 2.7125 (5.1); 2.6884 (4.9); 2.6706 (2.8); 2.6464 (2.5); 2.2335 (0.9); 2.2286 (1.2); 2.2243 (0.6); 2.2087 (1.6); 2.2043 (2.5); 2.2002 (1.5); 2.1947 (0.7); 2.1845 (1.6); 2.1798 (2.7); 2.1762 (2.7); 2.1682 (1.8); 2.1592 (1.8); 2.1551 (3.4); 2.1525 (3.5); 2.1484 (2.9); 2.1430 (2.5); 2.1378 (2.2); 2.1338 (2.8); 2.1279 (2.8); 2.1213 (2.8); 2.1133 (1.1); 2.1082 (1.0); 2.1012 (0.5); 2.0944 (0.9); 1.7356 (0.9); 1.7304 (0.6); 1.7283 (0.6); 1.7189 (2.7); 1.7108 (1.8); 1.7058 (2.4); 1.6949 (4.3); 1.6818 (2.6); 1.6709 (2.1); 1.6588 (0.7); 1.6555 (0.9); 1.5992 (2.3); 0.0080 (1.9); -0.0002 (66.4); -0.0085 (1.8) I.2-104: 1H-NMR (400.0 MHz, CDCl3): δ= 8.5582 (3.9); 8.5558 (4.6); 8.5541 (4.7); 8.5518 (4.1); 8.5459 (4.0); 8.5436 (4.6); 8.5419 (4.6); 8.5395 (3.7); 7.7685 (13.5); 7.7659 (14.2); 7.7494 (4.3); 7.7468 (5.0); 7.7440 (4.1); 7.7413 (2.8); 7.7223 (3.4); 7.7178 (3.4); 7.7031 (6.4); 7.6986 (6.3); 7.6839 (4.0); 7.6794 (3.8); 7.5193 (1.1); 7.4795 (3.0); 7.4774 (2.8); 7.4603 (5.6); 7.4582 (5.2); 7.4389 (3.0); 7.3164 (5.6); 7.3140 (4.5); 7.3100 (2.8); 7.2997 (4.1); 7.2972 (5.0); 7.2822 (8.2); 7.2750 (2.8); 7.2742 (2.7); 7.2734 (2.7); 7.2726 (2.8); 7.2717 (2.9); 7.2709 (3.1); 7.2701 (3.4); 7.2693 (3.7); 7.2603 (198.0); 7.2473 (4.0); 7.2460 (3.9); 7.2445 (3.8); 7.2427 (3.3); 7.2408 (3.8); 7.2284 (3.2); 7.2271 (3.1); 7.1351 (2.5); 6.9964 (1.1); 6.7791 (4.7); 6.6381 (9.5); 6.4972 (4.7); 4.6184 (16.0); 4.6068 (15.6); 4.2425 (5.5); 4.2237 (6.1); 4.2184 (7.0); 4.1997 (7.0); 4.0522 (6.6); 4.0306 (8.3); 4.0283 (6.9); 4.0066 (5.3); 3.3739 (1.3); 3.3521 (3.4); 3.3311 (4.0); 3.3291 (3.9); 3.3101 (3.5); 3.2883 (1.3); 3.0601 (5.3); 3.0382 (4.4); 3.0174 (8.5); 2.9955 (7.7); 2.9052 (8.4); 2.8816 (7.7); 2.8625 (5.0); 2.8389 (4.5); 1.6390 (3.5); 1.2552 (1.1); 0.0080 (2.7); -0.0002 (75.0); -0.0085 (2.5) I.2-105: 1H-NMR (400.0 MHz, CDCl3): δ= 8.5575 (4.7); 8.5470 (4.7); 7.7314 (3.3); 7.7269 (3.4); 7.7122 (6.4); 7.7078 (6.2); 7.6930 (3.9); 7.6885 (3.7); 7.5243 (5.7); 7.5186 (14.3); 7.5141 (5.5); 7.4434 (3.8); 7.4410 (4.4); 7.4382 (3.5); 7.4357 (3.4); 7.4227 (6.3); 7.4202 (6.5); 7.4174 (6.1); 7.4150 (5.0); 7.3671 (7.5); 7.3466 (11.6); 7.3261 (5.3); 7.3101 (1.8); 7.2874 (8.2); 7.2596 (1068.7); 7.2370 (3.6); 7.2305 (0.8); 7.2104 (2.1); 7.1285 (2.5); 6.9956 (5.9); 6.9306 (4.2); 6.9270 (3.9); 6.9103 (3.6); 6.9067 (3.6); 6.7088 (7.9); 6.5241 (15.9); 6.3395 (8.1); 4.6208 (16.0); 4.6092 (15.4); 4.2037 (5.2); 4.1849 (6.2); 4.1796 (7.1); 4.1608 (6.9); 4.0204 (6.6); 3.9987 (8.4); 3.9964 (6.6); 3.9747 (5.4); 3.3616 (1.2); 3.3399 (3.3); 3.3195 (3.9); 3.2976 (3.5); 3.2756 (1.2); 3.0509 (5.3); 3.0289 (4.3); 3.0082 (8.4); 2.9862 (7.8); 2.8973 (8.6); 2.8738 (7.8); 2.8546 (5.1); 2.8310 (4.5); 2.0051 (1.1); 1.5720 (14.7); 1.2560 (0.7); 0.1459 (1.2); 0.0079 (19.2); -0.0002 (403.6); -0.0085 (13.2); - 0.0315 (0.7); -0.0495 (0.9); -0.1497 (1.2) I.2-106: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7300 (15.7); 8.7178 (16.0); 7.5210 (0.7); 7.2621 (139.5); 7.2571 (6.4); 7.2446 (7.0); 7.2323 (3.4); 7.2120 (1.5); 6.9981 (0.8); 6.8853 (1.5); 4.7402 (5.4); 4.7354 (5.7); 4.7288 (5.7); 4.7243 (5.5); 4.5502 (0.6); 4.5298 (2.0); 4.5096 (2.8); 4.4893 (1.6); 3.7088 (2.6); 3.6908 (3.0); 3.6845 (3.9); 3.6665 (4.0); 3.5820 (3.8); 3.5603 (4.8); 3.5361 (3.0); 3.2347 (0.8); 3.2134 (1.9); 3.1953 (1.9); 3.1924 (2.4); 3.1894 (2.2); 3.1714 (2.0); 3.1501 (0.8); 2.8302 (2.6); 2.8092 (2.3); 2.7884 (5.4); 2.7675 (5.0); 2.7181 (5.6); 2.6940 (5.2); 2.6763 (2.8); 2.6522 (2.5); 1.8743 (1.5); 1.8632 (2.4); 1.8544 (2.0); 1.8476 (2.3); 1.8434 (2.5); 1.8322 (1.7); 1.8229 (1.2); 1.8181 (1.3); 1.7368 (0.5); 1.7019 (2.5); 1.6979 (2.8); 1.6907 (2.3); 1.6822 (2.5); 1.6601 (1.3); 1.6467 (1.5); 1.6217 (2.4); 1.6132 (2.4); 1.6043 (3.4); 1.5878 (8.1); 1.5665 (1.9); 1.5569 (1.6); 1.5493 (1.4); 1.5353 (1.4); 1.5159 (1.2); 1.5040 (1.1); 1.4855 (0.9); 1.2539 (0.5); 0.0080 (1.8); -0.0002 (60.9); -0.0085 (2.4); -0.0503 (0.7) I.2-107: 1H-NMR (400.0 MHz, CDCl3): δ= 8.7301 (9.9); 8.7178 (10.1); 7.2646 (48.3); 7.2603 (0.7); 7.2589 (1.2); 7.2572 (2.3); 7.2555 (1.2); 7.2467 (2.1); 7.2449 (4.1); 7.2432 (2.1); 7.2344 (1.0); 7.2326 (2.0); 7.2309 (1.0); 6.8970 (0.7); 4.7389 (3.8); 4.7272 (3.7); 3.7498 (1.8); 3.7322 (1.9); 3.7253 (2.3); 3.7077 (2.5); 3.5807 (2.5); 3.5589 (3.0); 3.5563 (2.2); 3.5344 (2.1); 3.2486 (0.6); 3.2452 (0.9); 3.2422 (0.7); 3.2276 (0.9); 3.2242 (1.3); 3.2209 (1.0); 3.2034 (0.9); 3.1998 (0.7); 3.1821 (0.5); 3.1725 (0.8); 3.1530 (0.8); 3.1388 (2.2); 3.1193 (2.3); 3.1046 (2.1); 3.0863 (2.1); 3.0708 (0.8); 3.0525 (0.8); 2.8474 (1.1); 2.8269 (1.0); 2.8055 (2.2); 2.7849 (2.0); 2.7299 (2.1); 2.7057 (1.9); 2.6879 (1.0); 2.6637 (1.0); 1.9644 (0.5); 1.9461 (0.9); 1.9291 (1.2); 1.9123 (1.0); 1.8935 (0.5); 1.6429 (0.5); 0.9224 (15.4); 0.9205 (16.0); 0.9058 (15.1); 0.9038 (15.6); 0.0080 (0.6); 0.0024 (0.6); 0.0016 (0.9); -0.0002 (22.6); -0.0085 (0.6) I.2-108: 1H-NMR (400.0 MHz, CDCl3): δ= 8.3161 (3.8); 8.3147 (3.9); 8.3099 (3.9); 8.3084 (3.8); 7.6341 (3.0); 7.6278 (2.9); 7.6136 (3.4); 7.6073 (3.4); 7.5199 (1.6); 7.3289 (5.0); 7.3275 (5.0); 7.3084 (4.4); 7.3069 (4.5); 7.2770 (0.6); 7.2722 (0.9); 7.2714 (1.0); 7.2706 (1.1); 7.2698 (1.2); 7.2674 (2.4); 7.2610 (301.4); 7.2569 (3.3); 7.2560 (2.3); 7.2552 (1.6); 7.2544 (1.2); 7.2536 (1.2); 7.2528 (1.1); 7.2520 (0.8); 7.2512 (0.7); 7.2504 (0.6); 7.2496 (0.6); 7.2488 (0.5); 7.2108 (2.0); 6.9970 (1.6); 5.9814 (1.1); 4.6512 (1.5); 4.6277 (2.2); 4.6074 (1.3); 4.5245 (1.0); 4.5095 (1.0); 4.4868 (3.5); 4.4716 (3.4); 4.4561 (3.4); 4.4412 (3.4); 4.4185 (1.1); 4.4035 (1.0); 3.7254 (1.9); 3.7071 (2.2); 3.7012 (3.9); 3.6829 (4.0); 3.6586 (4.0); 3.6371 (4.6); 3.6129 (2.2); 3.0840 (0.7); 3.0627 (1.7); 3.0444 (1.6); 3.0415 (2.1); 3.0386 (2.0); 3.0203 (1.8); 2.9990 (0.8); 2.7263 (2.1); 2.7052 (1.9); 2.6846 (5.2); 2.6634 (4.7); 2.6372 (5.4); 2.6131 (4.9); 2.5954 (2.2); 2.5713 (1.9); 2.2022 (0.9); 2.1782 (1.6); 2.1751 (2.0); 2.1516 (2.9); 2.1450 (3.6); 2.1409 (2.7); 2.1322 (2.6); 2.1236 (4.6); 2.1182 (3.2); 2.1119 (1.9); 2.1016 (2.0); 2.0967 (1.4); 1.7346 (0.9); 1.7273 (0.7); 1.7170 (2.5); 1.7105 (1.9); 1.7045 (2.1); 1.6937 (3.9); 1.6865 (1.3); 1.6809 (2.0); 1.6711 (1.8); 1.6551 (0.7); 1.5602 (16.0); 0.0080 (3.1); -0.0002 (129.7); -0.0085 (3.8); -0.0503 (0.8) I.2-109: 1H-NMR (400.0 MHz, CDCl3): δ= 8.5468 (2.0); 8.5362 (2.0); 7.7159 (1.4); 7.7115 (1.4); 7.6967 (2.7); 7.6923 (2.6); 7.6775 (1.7); 7.6731 (1.6); 7.5201 (0.7); 7.2723 (4.1); 7.2612 (131.9); 7.2532 (6.0); 7.2407 (2.4); 7.2344 (2.1); 7.2220 (1.6); 7.2116 (1.3); 7.0094 (1.0); 6.9972 (1.4); 4.5887 (6.8); 4.5770 (6.8); 3.7073 (1.9); 3.6895 (2.1); 3.6829 (2.7); 3.6652 (2.7); 3.5596 (2.6); 3.5378 (3.5); 3.5134 (2.2); 3.2235 (0.6); 3.2020 (1.2); 3.1813 (1.5); 3.1602 (2.0); 3.1395 (1.4); 3.1257 (2.8); 3.1061 (3.0); 3.0978 (2.8); 3.0794 (2.8); 3.0639 (0.9); 3.0455 (0.9); 2.8121 (1.3); 2.7916 (1.2); 2.7703 (2.7); 2.7496 (2.5); 2.6966 (2.6); 2.6724 (2.4); 2.6546 (1.3); 2.6306 (1.2); 1.9527 (0.6); 1.9352 (1.2); 1.9182 (1.5); 1.9012 (1.3); 1.8826 (0.6); 1.6314 (4.6); 0.9173 (16.0); 0.9133 (15.9); 0.9006 (16.0); 0.8966 (15.6); 0.0080 (1.9); -0.0002 (56.1); -0.0085 (2.5) I.2-110: 1H-NMR (400.0 MHz, CDCl3): δ= 7.2678 (0.6); 7.2670 (0.6); 7.2661 (0.8); 7.2654 (1.0); 7.2645 (1.3); 7.2606 (73.7); 7.2572 (1.1); 7.2564 (0.7); 7.2556 (0.5); 7.2107 (0.5); 1.5458 (16.0); 0.9110 (2.0); 0.9083 (2.0); 0.8944 (2.0); 0.8916 (2.0); 0.0080 (0.9); -0.0002 (32.0); -0.0085 (0.9) I.2-111: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7254 (2.6); 8.7110 (4.2); 8.6958 (2.3); 8.3387 (8.7); 8.3340 (8.6); 8.3324 (8.3); 7.7694 (6.4); 7.7631 (6.2); 7.7489 (7.4); 7.7425 (7.5); 7.6543 (12.0); 7.6514 (14.6); 7.6463 (3.8); 7.6346 (7.8); 7.6322 (16.0); 7.6296 (13.6); 7.5008 (11.6); 7.4991 (11.4); 7.4802 (9.8); 7.4786 (9.8); 7.3892 (11.8); 7.3840 (3.4); 7.3707 (14.4); 7.3677 (11.1); 7.3538 (4.0); 7.3491 (11.8); 7.1560 (3.1); 7.1532 (6.3); 7.1505 (3.5); 7.1348 (9.5); 7.1163 (4.6); 5.7555 (2.4); 4.3406 (14.4); 4.3259 (14.4); 4.2282 (0.9); 4.0387 (5.2); 4.0172 (6.8); 4.0144 (8.2); 3.9929 (7.1); 3.9106 (7.2); 3.8952 (7.4); 3.8864 (5.1); 3.8709 (5.4); 3.8258 (0.9); 3.3684 (2.6); 3.3184 (1093.9); 3.2981 (4.9); 3.2918 (4.8); 3.2684 (9.8); 3.2564 (2.3); 3.2186 (1.4); 2.7862 (4.4); 2.7629 (4.0); 2.7439 (9.8); 2.7206 (8.9); 2.6909 (9.5); 2.6725 (11.0); 2.6653 (4.6); 2.6607 (2.2); 2.6486 (3.9); 2.6303 (3.6); 2.5553 (1.6); 2.5507 (2.4); 2.5460 (2.1); 2.5234 (13.8); 2.5187 (20.2); 2.5100 (314.0); 2.5054 (701.2); 2.5008 (993.8); 2.4962 (697.4); 2.4916 (311.3); 2.4601 (4.0); 2.4555 (6.5); 2.4510 (8.2); 2.4463 (6.6); 2.4003 (1.7); 2.3369 (2.3); 2.3323 (4.6); 2.3276 (6.2); 2.3230 (4.8); 2.0733 (3.1); 0.0080 (5.8); 0.0048 (1.6); 0.0039 (2.3); 0.0023 (7.1); -0.0002 (206.0); -0.0051 (4.0); -0.0085 (6.4); -0.0501 (1.4) I.2-112: 1H-NMR (400.0 MHz, CDCl3): δ= 8.5527 (3.8); 8.5503 (4.3); 8.5484 (4.4); 8.5460 (4.0); 8.5405 (4.0); 8.5380 (4.4); 8.5362 (4.4); 8.5337 (3.8); 7.7130 (4.1); 7.7085 (4.2); 7.6938 (7.2); 7.6893 (7.2); 7.6746 (5.0); 7.6701 (4.8); 7.5218 (1.3); 7.3128 (0.6); 7.2813 (0.6); 7.2789 (0.7); 7.2781 (0.8); 7.2749 (2.6); 7.2733 (4.7); 7.2709 (8.1); 7.2694 (7.1); 7.2685 (6.9); 7.2670 (5.8); 7.2662 (6.5); 7.2629 (224.8); 7.2596 (4.5); 7.2587 (2.8); 7.2579 (2.1); 7.2571 (2.0); 7.2562 (2.1); 7.2554 (2.8); 7.2538 (4.6); 7.2506 (8.6); 7.2490 (7.5); 7.2476 (5.4); 7.2436 (0.8); 7.2428 (0.7); 7.2420 (0.7); 7.2380 (4.1); 7.2365 (3.4); 7.2351 (3.5); 7.2332 (3.0); 7.2315 (3.7); 7.2301 (3.5); 7.2286 (3.4); 7.2191 (3.4); 7.2178 (3.0); 7.2164 (2.9); 7.2131 (2.2); 7.0325 (2.1); 6.9988 (1.5); 4.6903 (0.8); 4.6697 (2.4); 4.6469 (4.1); 4.6271 (2.3); 4.6032 (1.1); 4.5903 (16.0); 4.5786 (15.8); 3.7467 (3.0); 3.7279 (3.8); 3.7226 (8.0); 3.7038 (8.4); 3.6947 (8.4); 3.6731 (9.4); 3.6490 (3.7); 3.2058 (1.5); 3.1842 (3.4); 3.1653 (3.3); 3.1628 (4.1); 3.1603 (3.9); 3.1414 (3.5); 3.1388 (2.2); 3.1198 (1.5); 2.8058 (5.1); 2.7843 (4.4); 2.7639 (9.1); 2.7423 (8.5); 2.6764 (9.6); 2.6524 (9.2); 2.6345 (5.4); 2.6104 (4.8); 2.2205 (1.5); 2.2157 (2.1); 2.1951 (2.5); 2.1914 (4.8); 2.1881 (3.0); 2.1823 (1.0); 2.1669 (5.7); 2.1643 (4.8); 2.1594 (4.0); 2.1465 (4.8); 2.1428 (5.3); 2.1399 (7.4); 2.1347 (4.9); 2.1328 (5.0); 2.1295 (3.9); 2.1261 (5.0); 2.1169 (4.6); 2.1128 (4.5); 2.1046 (2.0); 2.1005 (1.6); 2.0925 (0.9); 2.0825 (0.5); 1.7288 (1.6); 1.7231 (1.2); 1.7210 (1.2); 1.7115 (5.1); 1.7040 (3.3); 1.6987 (4.6); 1.6878 (8.3); 1.6745 (6.3); 1.6624 (11.2); 1.2553 (0.7); 0.0081 (2.6); 0.0066 (0.6); 0.0057 (0.6); 0.0049 (0.7); 0.0041 (0.9); 0.0024 (2.7); -0.0002 (98.1); -0.0085 (2.8); -0.0501 (0.9) I.2-114: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1118 (7.1); 8.0987 (7.1); 7.5182 (3.7); 7.2812 (8.8); 7.2593 (663.2); 7.2388 (8.2); 7.2332 (6.7); 7.2143 (0.9); 7.2078 (0.5); 6.9954 (3.6); 6.8651 (4.9); 6.8617 (4.9); 6.8520 (4.7); 6.8485 (4.6); 6.7227 (8.5); 6.6448 (1.7); 6.6391 (2.7); 6.6337 (1.4); 6.6229 (3.2); 6.6172 (5.3); 6.6116 (2.8); 6.6009 (1.8); 6.5952 (2.7); 6.5895 (1.3); 6.0172 (2.0); 4.7945 (5.3); 4.7732 (15.7); 4.7517 (16.0); 4.7303 (5.4); 4.5379 (1.1); 4.5236 (1.2); 4.4989 (5.9); 4.4854 (8.8); 4.4716 (5.6); 4.4468 (0.9); 4.4312 (0.8); 4.3331 (7.5); 4.3088 (7.7); 3.5797 (8.6); 3.5554 (8.0); 3.1429 (7.0); 3.1011 (8.1); 2.5660 (9.3); 2.5243 (7.9); 2.0432 (1.7); 1.5597 (41.8); 1.5332 (141.7); 1.3830 (0.9); 1.3652 (0.8); 1.3326 (0.6); 1.2840 (0.9); 1.2584 (2.0); 1.2404 (0.6); 0.1459 (1.0); 0.0079 (11.3); -0.0002 (260.6); -0.0084 (9.5); -0.1495 (0.9) I.2-115: 1H-NMR (400.0 MHz, CDCl3): δ= 8.4896 (2.3); 8.4769 (2.3); 7.2740 (1.7); 7.2683 (2.3); 7.2604 (37.2); 7.2506 (1.7); 7.2450 (1.4); 6.9965 (0.6); 6.9158 (1.7); 6.9031 (1.6); 6.6311 (0.5); 6.6149 (0.6); 6.6091 (1.1); 6.6034 (0.6); 6.5872 (0.5); 4.5301 (2.9); 4.5181 (2.9); 4.3199 (1.6); 4.2955 (1.6); 3.5827 (1.8); 3.5583 (1.7); 3.2043 (1.5); 3.1622 (1.7); 2.5869 (0.8); 2.5791 (16.0); 2.5363 (1.7); 2.0433 (1.6); 1.5856 (8.9); 1.2584 (1.0); 0.0078 (0.6); - 0.0002 (14.2); -0.0085 (0.5) I.2-118: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1116 (3.6); 8.0984 (3.6); 7.5186 (0.8); 7.3120 (0.9); 7.2596 (147.8); 7.2389 (4.1); 7.2334 (3.3); 7.2220 (0.6); 6.9956 (0.8); 6.7489 (2.3); 6.7388 (2.2); 6.6414 (1.0); 6.6358 (1.6); 6.6301 (1.0); 6.6196 (1.8); 6.6138 (2.9); 6.6081 (1.8); 6.5983 (4.7); 6.5921 (1.8); 6.5863 (0.8); 6.0297 (1.0); 4.4910 (0.6); 4.4657 (3.3); 4.4601 (3.3); 4.4511 (3.2); 4.4455 (3.0); 4.3339 (3.7); 4.3095 (3.9); 4.2696 (4.9); 4.2528 (9.7); 4.2359 (4.8); 3.5731 (4.1); 3.5488 (3.9); 3.1496 (3.5); 3.1077 (3.9); 2.5571 (4.4); 2.5153 (3.8); 1.8367 (0.8); 1.8183 (2.4); 1.8011 (4.7); 1.7827 (4.7); 1.7655 (2.6); 1.7473 (0.8); 1.5503 (19.9); 1.2564 (0.6); 1.0376 (8.2); 1.0191 (16.0); 1.0005 (7.2); 0.0079 (2.8); -0.0002 (55.5); -0.0084 (2.3) I.2-119: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1648 (3.8); 8.1509 (3.9); 7.6467 (3.6); 7.5874 (15.6); 7.5829 (16.0); 7.5180 (4.8); 7.4644 (8.0); 7.2941 (1.2); 7.2822 (5.1); 7.2592 (882.8); 7.2262 (1.6); 7.2088 (2.0); 7.1671 (4.4); 7.1626 (7.9); 7.1581 (4.0); 6.9952 (5.0); 6.9907 (2.9); 6.9775 (2.6); 6.7587 (4.8); 6.7570 (4.8); 6.0514 (1.1); 4.5269 (2.8); 4.5119 (3.0); 4.5065 (3.0); 4.4913 (2.9); 4.4655 (0.8); 4.3364 (4.0); 4.3120 (4.1); 3.5856 (4.6); 3.5610 (4.3); 3.1272 (4.0); 3.0853 (4.6); 2.5661 (5.0); 2.5242 (4.3); 2.1356 (1.0); 2.1005 (1.0); 2.0431 (1.8); 1.5592 (21.7); 1.5308 (184.7); 1.2585 (2.0); 1.2406 (0.8); 0.1463 (1.1); 0.0080 (12.4); -0.0002 (339.5); - 0.0085 (10.8); -0.1493 (1.0) I.2-120: 1H-NMR (400.6 MHz, CDCl3): δ= 8.4663 (4.9); 8.4538 (5.0); 7.5946 (12.2); 7.5901 (13.0); 7.5853 (0.8); 7.5199 (1.0); 7.2867 (0.6); 7.2822 (0.9); 7.2743 (1.4); 7.2614 (172.4); 7.1549 (3.4); 7.1505 (6.1); 7.1460 (2.9); 6.9978 (1.0); 6.9561 (0.9); 6.8842 (3.6); 6.8717 (3.5); 4.5259 (5.7); 4.5146 (5.6); 4.4708 (2.4); 4.4531 (7.7); 4.4354 (7.8); 4.4178 (2.4); 4.3269 (3.0); 4.3026 (3.2); 4.1308 (1.0); 4.1130 (1.0); 3.5827 (3.4); 3.5584 (3.3); 3.1913 (2.9); 3.1492 (3.3); 2.5751 (3.8); 2.5332 (3.4); 2.1346 (0.6); 2.1016 (2.0); 2.0454 (4.8); 1.5761 (19.3); 1.5688 (8.9); 1.5365 (1.2); 1.4766 (7.8); 1.4590 (16.0); 1.4413 (7.5); 1.3326 (1.4); 1.2843 (2.0); 1.2774 (1.8); 1.2595 (4.7); 1.2555 (3.5); 1.2417 (1.7); 0.8800 (0.7); 0.0079 (1.6); -0.0002 (49.6); -0.0085 (1.6) I.2-122: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1342 (1.2); 8.1328 (1.2); 8.1210 (1.2); 8.1196 (1.2); 7.2712 (0.6); 7.2601 (62.9); 7.2559 (1.9); 7.2542 (2.0); 7.2502 (0.7); 7.2405 (0.6); 7.2362 (1.4); 7.2305 (1.2); 6.7608 (0.8); 6.7571 (0.9); 6.7475 (0.8); 6.7439 (0.9); 6.6368 (0.5); 6.6206 (0.6); 6.6148 (1.1); 6.6091 (0.6); 6.5959 (1.3); 6.5939 (1.8); 6.5924 (1.8); 6.5904 (1.2); 5.2983 (2.2); 4.4685 (1.0); 4.4556 (1.3); 4.4426 (1.0); 4.3290 (1.3); 4.3046 (1.4); 3.9331 (16.0); 3.5700 (1.5); 3.5456 (1.4); 3.1425 (1.3); 3.1006 (1.4); 2.5533 (1.6); 2.5115 (1.4); 1.5476 (11.0); 1.2837 (0.6); 1.2558 (2.0); 0.0080 (0.7); -0.0002 (22.7); -0.0084 (0.7) I.2-123: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1381 (1.7); 8.1249 (1.8); 7.5877 (7.6); 7.5833 (7.7); 7.5184 (3.1); 7.2595 (579.1); 7.2272 (0.6); 7.1626 (1.9); 7.1580 (3.6); 7.1535 (1.8); 6.9955 (3.2); 6.7624 (1.1); 6.7497 (1.1); 6.5993 (2.0); 4.4706 (1.2); 4.4606 (1.5); 4.4459 (1.2); 4.3371 (1.7); 4.3128 (2.0); 3.9399 (16.0); 3.5735 (2.1); 3.5491 (2.0); 3.1354 (1.7); 3.0934 (2.0); 2.5497 (2.2); 2.5079 (2.0); 2.0434 (1.6); 1.5436 (16.9); 1.5361 (33.2); 1.2842 (0.7); 1.2763 (0.8); 1.2584 (2.4); 1.2390 (0.9); 0.1459 (0.7); 0.0080 (6.5); -0.0002 (218.1); -0.0085 (6.1); -0.1495 (0.7) I.2-124: 1H-NMR (400.6 MHz, CDCl3): δ= 8.4657 (5.4); 8.4532 (5.6); 7.5202 (0.9); 7.2689 (5.3); 7.2617 (169.9); 7.2496 (1.5); 7.2455 (3.1); 7.2399 (2.8); 7.2302 (0.6); 6.9981 (1.3); 6.9824 (0.9); 6.8873 (3.6); 6.8748 (3.5); 6.6372 (0.7); 6.6315 (1.2); 6.6257 (0.6); 6.6153 (1.4); 6.6096 (2.3); 6.6039 (1.2); 6.5934 (0.7); 6.5877 (1.2); 6.5819 (0.5); 4.5265 (5.8); 4.5142 (5.7); 4.4689 (2.3); 4.4512 (7.2); 4.4335 (7.4); 4.4158 (2.3); 4.3212 (3.0); 4.2969 (3.2); 4.2719 (0.5); 4.2470 (0.6); 3.6256 (0.6); 3.6006 (0.6); 3.5822 (3.5); 3.5579 (3.3); 3.2100 (0.6); 3.2001 (3.0); 3.1667 (0.7); 3.1580 (3.3); 2.6000 (0.7); 2.5839 (3.8); 2.5568 (0.6); 2.5418 (3.3); 2.1347 (1.5); 2.1031 (2.4); 1.5803 (17.6); 1.5593 (4.3); 1.5418 (1.2); 1.4741 (8.0); 1.4564 (16.0); 1.4388 (8.0); 1.4252 (1.0); 1.3324 (0.6); 1.2843 (0.8); 1.2554 (1.1); 0.0080 (1.7); -0.0002 (49.8); -0.0084 (1.6) I.2-125: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1135 (2.5); 8.1121 (2.6); 8.1004 (2.5); 8.0989 (2.5); 7.5181 (1.7); 7.2921 (1.0); 7.2739 (1.3); 7.2592 (317.9); 7.2393 (2.8); 7.2337 (2.4); 6.9952 (1.7); 6.7391 (1.7); 6.7354 (1.8); 6.7259 (1.6); 6.7222 (1.7); 6.6422 (0.6); 6.6364 (1.1); 6.6306 (0.6); 6.6202 (1.2); 6.6145 (2.1); 6.6088 (1.1); 6.5982 (0.6); 6.5925 (1.1); 6.5869 (0.6); 6.5755 (2.3); 6.5736 (3.1); 6.5718 (3.0); 6.5700 (2.3); 5.9659 (0.6); 4.4614 (2.1); 4.4542 (2.1); 4.4466 (2.1); 4.4395 (2.0); 4.3823 (2.2); 4.3647 (7.0); 4.3470 (7.3); 4.3323 (2.8); 4.3294 (2.7); 4.3080 (2.7); 3.5699 (2.9); 3.5455 (2.8); 3.1470 (2.5); 3.1052 (2.9); 2.5534 (3.2); 2.5114 (2.8); 2.0985 (0.5); 1.5480 (14.6); 1.5347 (37.5); 1.4025 (7.5); 1.3848 (16.0); 1.3672 (7.2); 1.2565 (0.6); 0.0079 (3.9); 0.0063 (1.5); 0.0054 (1.6); -0.0002 (119.3); -0.0068 (1.4); -0.0085 (3.5) I.2-126: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1155 (2.4); 8.1008 (2.5); 7.5892 (10.6); 7.5847 (11.1); 7.5180 (2.7); 7.2591 (510.6); 7.2509 (1.8); 7.2500 (1.5); 7.2493 (1.3); 7.2484 (1.3); 7.2476 (1.2); 7.2452 (0.8); 7.2436 (0.7); 7.2413 (0.6); 7.2341 (0.5); 7.1616 (2.9); 7.1570 (5.6); 7.1525 (2.7); 6.9952 (2.7); 6.7395 (1.6); 6.7358 (1.7); 6.7264 (1.5); 6.7227 (1.6); 6.5764 (2.3); 6.5746 (2.8); 6.5727 (2.8); 5.9585 (0.6); 4.4603 (1.9); 4.4532 (2.1); 4.4456 (2.0); 4.4385 (2.0); 4.3838 (2.0); 4.3661 (6.7); 4.3485 (6.8); 4.3389 (2.4); 4.3308 (2.2); 4.3145 (2.6); 3.5719 (2.8); 3.5478 (2.7); 3.1392 (2.4); 3.0972 (2.7); 2.5465 (3.1); 2.5045 (2.7); 2.0994 (0.6); 2.0428 (1.5); 1.5434 (14.3); 1.5330 (64.8); 1.4036 (7.6); 1.3860 (16.0); 1.3682 (7.2); 1.2761 (0.5); 1.2583 (1.3); 0.1460 (0.6); 0.0079 (5.7); 0.0062 (2.2); -0.0002 (186.9); -0.0060 (1.8); -0.0069 (1.5); -0.0085 (5.1); - 0.1497 (0.5) I.2-127: 1H-NMR (400.0 MHz, CDCl3): δ= 8.2233 (0.8); 8.2116 (0.8); 7.5974 (10.3); 7.5929 (10.8); 7.5191 (0.8); 7.2602 (137.9); 7.2098 (0.5); 7.1978 (0.5); 7.1573 (2.7); 7.1528 (4.8); 7.1483 (2.5); 6.9962 (0.8); 6.4868 (2.8); 6.4741 (2.8); 4.4197 (1.9); 4.4096 (2.5); 4.4011 (1.5); 4.3308 (2.6); 4.3065 (2.7); 4.1306 (0.6); 4.1128 (0.6); 3.5894 (3.2); 3.5650 (3.0); 3.1986 (2.4); 3.1564 (2.7); 3.0250 (7.9); 3.0127 (7.8); 2.5806 (3.6); 2.5384 (3.1); 2.1307 (0.9); 2.0985 (16.0); 2.0437 (3.0); 1.5864 (0.9); 1.5739 (13.8); 1.5468 (1.4); 1.3323 (1.1); 1.2842 (1.6); 1.2763 (1.2); 1.2584 (4.2); 1.2406 (1.1); 0.8800 (0.6); 0.0080 (1.6); -0.0002 (53.6); -0.0085 (1.9) I.2-129: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1052 (1.3); 8.1038 (1.3); 8.0921 (1.3); 8.0906 (1.3); 7.5182 (0.6); 7.2749 (0.5); 7.2685 (0.8); 7.2594 (105.3); 7.2442 (0.6); 7.2399 (1.4); 7.2343 (1.2); 6.9954 (0.6); 6.7095 (0.9); 6.7058 (1.0); 6.6964 (0.9); 6.6926 (0.9); 6.6359 (0.6); 6.6196 (0.6); 6.6140 (1.1); 6.6083 (0.5); 6.5920 (0.6); 6.5303 (1.2); 6.5285 (1.6); 6.5266 (1.6); 6.5248 (1.2); 5.3181 (1.0); 5.3026 (1.4); 5.2871 (1.0); 4.4478 (1.2); 4.4435 (1.2); 4.4331 (1.2); 4.4307 (1.1); 4.4288 (1.2); 4.3331 (1.4); 4.3086 (1.5); 3.5694 (1.6); 3.5450 (1.5); 3.1490 (1.3); 3.1071 (1.5); 2.5512 (1.7); 2.5094 (1.5); 1.5470 (8.2); 1.5397 (15.6); 1.3445 (16.0); 1.3356 (0.9); 1.3290 (15.9); 0.0080 (1.2); 0.0055 (0.5); -0.0002 (38.2); -0.0085 (1.0) I.2-130: 1H-NMR (400.0 MHz, CDCl3): δ= 8.2280 (0.9); 8.2149 (0.9); 7.5183 (1.4); 7.2834 (0.8); 7.2719 (3.8); 7.2661 (5.8); 7.2595 (247.0); 7.2536 (2.6); 7.2528 (2.6); 7.2503 (2.4); 7.2482 (3.6); 7.2426 (3.2); 7.2369 (0.8); 7.2313 (0.6); 7.2297 (0.5); 6.9955 (1.4); 6.6380 (0.7); 6.6323 (1.3); 6.6266 (0.6); 6.6160 (1.4); 6.6103 (2.5); 6.6046 (1.3); 6.5941 (0.8); 6.5884 (1.3); 6.5827 (0.6); 6.4843 (3.3); 6.4717 (3.3); 4.4205 (2.0); 4.4101 (2.6); 4.4021 (1.7); 4.3273 (3.0); 4.3030 (3.1); 4.1304 (0.6); 4.1126 (0.5); 3.5835 (3.7); 3.5592 (3.5); 3.2081 (2.7); 3.1660 (3.1); 3.0242 (11.6); 3.0116 (11.3); 2.5905 (0.7); 2.5855 (3.8); 2.5435 (3.3); 2.1938 (0.5); 2.1693 (0.5); 2.1312 (0.8); 2.0988 (16.0); 2.0430 (2.8); 1.5789 (15.9); 1.5531 (1.7); 1.3325 (1.2); 1.2842 (1.7); 1.2761 (1.0); 1.2582 (3.2); 1.2404 (0.9); 0.0079 (3.0); -0.0002 (99.8); -0.0060 (1.1); -0.0069 (0.9); -0.0085 (2.9) I.2-131: 1H-NMR (400.0 MHz, CDCl3): δ= 8.4817 (6.6); 8.4690 (6.8); 7.6056 (15.2); 7.6011 (16.0); 7.5186 (2.0); 7.3601 (0.8); 7.2918 (0.6); 7.2597 (357.0); 7.2547 (3.6); 7.2539 (2.5); 7.2531 (1.8); 7.2522 (1.5); 7.2514 (1.3); 7.2507 (1.1); 7.2498 (1.0); 7.2490 (0.8); 7.2483 (0.8); 7.2474 (0.7); 7.2467 (0.6); 7.1558 (4.0); 7.1513 (7.9); 7.1468 (3.9); 6.9957 (2.4); 6.9832 (0.9); 6.9065 (3.9); 6.8938 (3.9); 4.5245 (3.4); 4.5218 (3.4); 4.5124 (3.3); 4.5098 (3.4); 4.3262 (3.3); 4.3018 (3.5); 4.1304 (0.9); 4.1126 (1.0); 3.5856 (3.8); 3.5614 (3.7); 3.1984 (3.4); 3.1951 (3.2); 3.1766 (8.9); 3.1581 (10.7); 3.1398 (2.9); 2.5647 (4.2); 2.5226 (3.7); 2.0435 (4.6); 1.5788 (20.6); 1.4400 (9.8); 1.4216 (21.9); 1.4032 (9.6); 1.2765 (1.5); 1.2586 (3.3); 1.2407 (1.5); 0.0104 (0.6); 0.0095 (0.8); 0.0080 (4.2); 0.0065 (1.3); 0.0056 (1.4); 0.0048 (1.7); 0.0040 (2.3); 0.0031 (3.5); 0.0023 (5.6); -0.0002 (129.2); -0.0050 (1.9); -0.0058 (1.4); -0.0067 (1.2); -0.0085 (3.6); -0.0114 (0.6) I.2-132: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1258 (1.5); 8.1242 (1.5); 8.1130 (1.5); 8.1113 (1.6); 7.5869 (6.8); 7.5824 (7.0); 7.5184 (0.7); 7.2596 (129.4); 7.1584 (1.7); 7.1539 (3.3); 7.1494 (1.6); 6.9956 (0.7); 6.3929 (1.0); 6.3895 (1.2); 6.3800 (1.0); 6.3766 (1.1); 6.3315 (1.9); 6.3301 (1.9); 4.4007 (1.3); 4.3880 (1.7); 4.3754 (1.3); 4.3400 (1.8); 4.3158 (1.8); 3.6067 (0.9); 3.5890 (3.0); 3.5713 (3.2); 3.5653 (2.2); 3.5536 (1.0); 3.5409 (1.9); 3.1334 (1.7); 3.0914 (1.9); 3.0211 (16.0); 2.5352 (2.2); 2.4933 (1.9); 2.0767 (2.2); 2.0429 (1.6); 1.5276 (9.1); 1.2761 (0.6); 1.2582 (1.4); 1.2404 (0.5); 1.1661 (3.8); 1.1484 (8.6); 1.1307 (3.8); 0.0079 (1.4); -0.0002 (52.0); - 0.0085 (1.6) I.2-133: 1H-NMR (400.0 MHz, CDCl3): δ= 8.6204 (0.8); 8.6028 (15.9); 8.5901 (16.0); 7.5183 (7.1); 7.3601 (0.7); 7.3490 (0.7); 7.3220 (0.8); 7.3099 (2.5); 7.2909 (2.6); 7.2835 (3.4); 7.2721 (13.9); 7.2706 (12.4); 7.2659 (22.0); 7.2595 (1275.4); 7.2529 (11.4); 7.2512 (7.4); 7.2504 (7.7); 7.2487 (10.6); 7.2438 (15.8); 7.2369 (2.3); 7.2312 (11.2); 7.2249 (1.0); 7.2099 (1.7); 7.1598 (0.8); 6.9955 (6.9); 6.7503 (2.1); 6.6405 (1.8); 6.6348 (3.4); 6.6292 (1.8); 6.6186 (3.9); 6.6129 (6.9); 6.6072 (3.3); 6.5967 (2.1); 6.5910 (3.5); 6.5854 (1.6); 4.6415 (0.6); 4.5978 (9.4); 4.5950 (9.3); 4.5846 (9.0); 4.5818 (9.4); 4.3146 (8.9); 4.2901 (9.5); 4.1483 (0.7); 4.1304 (2.0); 4.1126 (1.8); 4.0949 (0.7); 3.5939 (10.4); 3.5695 (9.6); 3.1930 (8.6); 3.1508 (9.9); 2.5982 (11.2); 2.5561 (9.8); 2.1356 (0.6); 2.0434 (9.2); 1.5942 (48.4); 1.5343 (315.3); 1.4194 (1.4); 1.4020 (1.3); 1.3327 (1.2); 1.2842 (1.7); 1.2764 (3.0); 1.2585 (6.7); 1.2407 (2.7); 0.1460 (1.5); 0.0503 (0.9); 0.0080 (15.8); -0.0002 (525.0); -0.0085 (15.0); -0.0498 (0.8); -0.1496 (1.6) I.2-136: 1H-NMR (400.0 MHz, CDCl3): δ= 8.0843 (12.6); 8.0712 (12.8); 7.5183 (4.9); 7.2946 (1.1); 7.2869 (1.9); 7.2751 (4.8); 7.2594 (869.3); 7.2445 (6.4); 7.2404 (13.8); 7.2347 (11.6); 7.2289 (2.6); 7.2261 (2.9); 7.2233 (1.7); 7.2159 (1.2); 6.9954 (4.7); 6.6872 (8.2); 6.6834 (8.5); 6.6741 (8.1); 6.6703 (8.2); 6.6406 (2.7); 6.6349 (5.1); 6.6292 (2.5); 6.6187 (5.5); 6.6130 (9.9); 6.6073 (4.9); 6.5967 (3.1); 6.5910 (5.0); 6.5854 (2.4); 6.5019 (11.7); 6.5001 (14.8); 6.4983 (14.4); 5.9232 (3.1); 4.4479 (0.9); 4.4235 (11.5); 4.4190 (11.5); 4.4088 (11.4); 4.4044 (11.2); 4.3800 (0.7); 4.3656 (0.7); 4.3322 (12.8); 4.3078 (13.5); 3.5657 (14.6); 3.5413 (13.8); 3.1488 (12.3); 3.1070 (13.9); 2.5450 (16.0); 2.5031 (14.1); 2.0041 (0.7); 1.7324 (1.1); 1.5918 (3.8); 1.5765 (394.5); 1.5533 (12.8); 1.5410 (74.1); 1.5360 (212.7); 1.4173 (1.8); 1.3727 (0.9); 1.3552 (0.8); 1.2839 (1.6); 1.2632 (3.4); 0.8987 (1.7); 0.8819 (5.1); 0.8644 (2.1); 0.1457 (1.1); 0.0080 (11.2); -0.0002 (335.7); -0.0085 (9.8); -0.0335 (0.7); -0.1496 (1.0) I.2-137: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1245 (1.7); 8.1230 (1.6); 8.1117 (1.7); 8.1101 (1.6); 7.5185 (0.6); 7.2797 (0.6); 7.2724 (1.1); 7.2596 (116.4); 7.2514 (1.2); 7.2413 (0.8); 7.2373 (1.8); 7.2316 (1.6); 6.9956 (0.6); 6.6336 (0.7); 6.6174 (0.8); 6.6117 (1.4); 6.6060 (0.7); 6.5898 (0.7); 6.3935 (1.1); 6.3902 (1.2); 6.3806 (1.0); 6.3773 (1.1); 6.3330 (2.1); 4.4026 (1.4); 4.3899 (1.8); 4.3771 (1.3); 4.3356 (1.8); 4.3112 (1.9); 3.6070 (1.0); 3.5893 (3.1); 3.5716 (3.2); 3.5621 (2.2); 3.5539 (1.1); 3.5377 (1.9); 3.1412 (1.7); 3.0993 (2.0); 3.0351 (0.7); 3.0212 (16.0); 2.5413 (2.2); 2.4994 (1.9); 1.5519 (1.7); 1.5324 (10.1); 1.1657 (4.0); 1.1571 (0.6); 1.1480 (8.6); 1.1303 (3.8); 0.0080 (1.6); -0.0002 (45.7); -0.0085 (1.3) I.2-138: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1708 (6.2); 8.1693 (6.1); 8.1581 (6.3); 8.1565 (6.1); 7.5183 (3.8); 7.2985 (0.7); 7.2929 (1.3); 7.2794 (2.0); 7.2770 (2.9); 7.2755 (2.9); 7.2738 (3.4); 7.2722 (4.2); 7.2714 (4.7); 7.2691 (6.7); 7.2682 (7.0); 7.2674 (7.9); 7.2666 (8.9); 7.2594 (661.2); 7.2544 (9.0); 7.2536 (8.3); 7.2527 (9.4); 7.2505 (5.3); 7.2497 (4.0); 7.2488 (3.6); 7.2481 (3.5); 7.2465 (2.0); 7.2457 (1.5); 7.2449 (1.2); 7.2441 (1.3); 7.2433 (1.2); 7.2425 (1.1); 7.2409 (1.4); 7.2385 (2.9); 7.2345 (7.2); 7.2289 (6.2); 7.2233 (1.0); 7.2171 (1.0); 7.2098 (0.9); 6.9954 (3.6); 6.6436 (1.6); 6.6380 (2.8); 6.6322 (1.5); 6.6218 (3.1); 6.6160 (5.4); 6.6104 (2.6); 6.5998 (1.7); 6.5942 (2.7); 6.5884 (1.4); 6.5401 (4.1); 6.5368 (4.5); 6.5241 (4.5); 6.4974 (7.5); 5.9398 (1.6); 4.4177 (8.5); 4.4031 (8.2); 4.3318 (6.8); 4.3073 (7.1); 4.1479 (1.0); 4.1301 (2.8); 4.1122 (2.9); 4.0943 (1.0); 3.8264 (14.2); 3.8144 (16.0); 3.8018 (15.9); 3.5662 (7.9); 3.5418 (7.4); 3.5105 (15.9); 3.4978 (15.2); 3.4858 (13.0); 3.1259 (6.6); 3.0841 (7.5); 2.5532 (8.5); 2.5114 (7.3); 2.0861 (2.3); 2.0429 (13.5); 1.5573 (4.9); 1.5346 (38.4); 1.4291 (0.6); 1.4125 (0.6); 1.3492 (0.5); 1.3328 (0.6); 1.2839 (1.1); 1.2762 (4.2); 1.2584 (9.8); 1.2405 (4.1); 0.8804 (0.7); 0.1458 (0.7); 0.0079 (8.6); 0.0062 (4.0); -0.0002 (257.6); -0.0052 (3.1); -0.0060 (2.4); -0.0069 (2.3); -0.0085 (7.4); -0.0124 (0.8); -0.1496 (0.7) I.2-139: 1H-NMR (400.0 MHz, CDCl3): δ= 8.0854 (3.9); 8.0842 (3.9); 8.0724 (4.0); 8.0711 (4.0); 7.5897 (15.8); 7.5852 (16.0); 7.5183 (1.1); 7.2594 (195.3); 7.2496 (0.7); 7.2480 (0.5); 7.1593 (4.0); 7.1548 (7.4); 7.1502 (3.8); 6.9954 (1.1); 6.6871 (2.6); 6.6833 (2.7); 6.6741 (2.5); 6.6703 (2.6); 6.5021 (3.5); 6.5004 (4.6); 6.4985 (4.5); 6.4968 (3.5); 5.9252 (1.0); 4.4214 (3.4); 4.4165 (3.5); 4.4069 (3.4); 4.4020 (3.4); 4.3377 (4.0); 4.3133 (4.2); 4.1295 (0.6); 4.1117 (0.6); 3.5673 (4.6); 3.5429 (4.3); 3.1401 (3.9); 3.0982 (4.4); 2.5367 (5.0); 2.4948 (4.4); 2.0964 (0.7); 2.0424 (2.7); 1.5916 (0.8); 1.5768 (130.4); 1.5534 (0.9); 1.5361 (26.4); 1.3042 (1.1); 1.2841 (1.5); 1.2758 (2.8); 1.2649 (5.4); 1.2582 (4.2); 1.2402 (1.2); 0.8989 (2.9); 0.8819 (10.6); 0.8642 (3.9); 0.0692 (0.5); 0.0080 (2.2); -0.0002 (80.5); -0.0085 (2.4) I.2-140: 1H-NMR (400.0 MHz, CDCl3): δ= 8.4522 (12.8); 8.4397 (13.0); 7.5198 (1.0); 7.2872 (1.2); 7.2797 (2.0); 7.2679 (10.7); 7.2609 (179.8); 7.2446 (8.3); 7.2391 (6.9); 7.2335 (1.4); 7.2274 (1.2); 7.2202 (0.5); 6.9968 (1.2); 6.9322 (2.5); 6.8524 (9.4); 6.8399 (9.1); 6.6350 (1.6); 6.6293 (2.9); 6.6236 (1.6); 6.6131 (3.3); 6.6073 (5.7); 6.6017 (2.9); 6.5911 (1.8); 6.5854 (2.9); 6.5797 (1.4); 5.3166 (1.9); 5.3009 (5.4); 5.2987 (4.8); 5.2855 (6.6); 5.2700 (4.9); 5.2545 (2.0); 4.5147 (16.0); 4.5026 (15.8); 4.3190 (8.1); 4.2947 (8.6); 3.5772 (9.3); 3.5529 (8.8); 3.1987 (7.9); 3.1565 (8.9); 2.5752 (10.1); 2.5497 (1.0); 2.5332 (8.9); 2.2833 (0.6); 2.1941 (0.8); 2.1295 (3.7); 2.0988 (0.9); 1.5769 (46.6); 1.4381 (2.8); 1.4262 (39.2); 1.4108 (38.7); 1.3328 (1.9); 1.2842 (2.7); 1.2568 (5.4); 0.8966 (0.7); 0.8803 (1.8); 0.8628 (0.9); 0.0079 (2.2); -0.0002 (64.4); -0.0084 (2.5) I.2-141: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1581 (7.2); 8.1451 (7.3); 7.6430 (7.5); 7.5192 (1.0); 7.4607 (16.0); 7.2784 (8.4); 7.2734 (1.7); 7.2604 (179.0); 7.2545 (7.7); 7.2489 (7.7); 7.2449 (2.8); 7.2352 (3.1); 7.2310 (7.6); 7.2254 (6.4); 7.2196 (1.1); 7.2138 (1.0); 6.9963 (1.2); 6.9888 (5.1); 6.9869 (4.3); 6.9851 (5.1); 6.9757 (4.8); 6.9739 (4.1); 6.9721 (4.9); 6.7545 (7.1); 6.7527 (8.9); 6.7510 (8.7); 6.7492 (6.5); 6.6465 (1.8); 6.6408 (3.2); 6.6351 (1.6); 6.6246 (3.6); 6.6189 (6.3); 6.6132 (3.1); 6.6027 (1.9); 6.5970 (3.1); 6.5913 (1.5); 6.1294 (1.7); 4.5629 (1.1); 4.5477 (1.2); 4.5232 (5.4); 4.5079 (5.9); 4.5057 (5.6); 4.5036 (5.8); 4.4884 (5.3); 4.4637 (1.2); 4.4488 (1.1); 4.3260 (7.7); 4.3015 (8.2); 4.1279 (0.7); 4.1101 (0.7); 3.5829 (9.0); 3.5585 (8.5); 3.1317 (7.5); 3.0898 (8.6); 2.5680 (9.8); 2.5262 (8.4); 2.1312 (0.7); 2.0420 (3.4); 1.5614 (42.6); 1.5545 (28.0); 1.2817 (0.7); 1.2756 (1.2); 1.2577 (3.0); 1.2399 (1.1); 0.0079 (2.3); -0.0002 (67.0); -0.0085 (1.9) I.2-142: 1H-NMR (400.0 MHz, CDCl3): δ= 8.3342 (2.9); 8.3215 (2.9); 7.4361 (1.8); 7.4323 (3.2); 7.4276 (1.9); 7.2872 (2.9); 7.2628 (37.6); 7.1940 (3.5); 7.1924 (3.5); 7.1048 (2.0); 7.1031 (1.8); 7.1012 (1.9); 7.0920 (1.9); 7.0885 (1.8); 6.9815 (3.0); 6.3794 (0.8); 4.4895 (2.2); 4.4756 (3.7); 4.4614 (2.1); 4.3291 (3.1); 4.3044 (3.3); 4.1440 (0.9); 4.1262 (2.6); 4.1083 (2.7); 4.0904 (0.9); 3.5933 (3.6); 3.5686 (3.4); 3.0964 (2.9); 3.0547 (3.3); 2.9516 (0.9); 2.8673 (0.8); 2.5411 (3.7); 2.4994 (3.2); 2.3330 (16.0); 2.3320 (15.8); 2.0412 (12.3); 1.5458 (16.6); 1.2815 (0.5); 1.2752 (3.6); 1.2573 (8.0); 1.2395 (3.5); -0.0002 (13.4) I.2-143: 1H-NMR (400.0 MHz, CDCl3): δ= 8.4912 (2.5); 8.4784 (2.5); 7.6050 (5.7); 7.6004 (5.8); 7.5185 (0.8); 7.2597 (139.2); 7.2474 (0.6); 7.2096 (0.6); 7.1563 (1.4); 7.1517 (2.7); 7.1473 (1.4); 6.9957 (1.0); 6.9162 (1.7); 6.9034 (1.7); 4.5299 (2.0); 4.5176 (2.0); 4.3262 (1.5); 4.3019 (1.6); 4.1305 (0.8); 4.1126 (0.8); 3.5883 (1.8); 3.5640 (1.6); 3.1986 (1.5); 3.1565 (1.7); 2.5810 (16.0); 2.5707 (2.0); 2.5286 (1.7); 2.0435 (3.8); 1.5815 (8.6); 1.5563 (2.2); 1.2765 (1.1); 1.2586 (2.4); 1.2407 (1.1); 0.0080 (1.8); -0.0002 (55.4); -0.0085 (1.8) I.2-144: 1H-NMR (400.0 MHz, CDCl3): δ= 8.3258 (11.8); 8.3130 (12.0); 7.5643 (10.6); 7.5613 (14.0); 7.5565 (4.0); 7.5422 (16.0); 7.5401 (14.8); 7.5343 (1.8); 7.5214 (0.9); 7.3967 (2.1); 7.3919 (12.9); 7.3866 (4.1); 7.3785 (2.8); 7.3732 (17.0); 7.3709 (13.0); 7.3654 (2.1); 7.3564 (4.6); 7.3517 (12.6); 7.3463 (1.5); 7.2746 (0.5); 7.2738 (0.5); 7.2731 (0.6); 7.2723 (0.6); 7.2698 (1.1); 7.2624 (148.7); 7.2008 (4.9); 7.1979 (12.6); 7.1949 (16.5); 7.1927 (14.2); 7.1831 (4.3); 7.1795 (11.4); 7.1758 (3.8); 7.1637 (3.0); 7.1609 (5.3); 7.1581 (2.7); 7.1004 (7.8); 7.0986 (6.8); 7.0968 (7.4); 7.0876 (7.6); 7.0859 (6.5); 7.0840 (7.1); 6.9984 (0.9); 6.4489 (2.5); 5.2977 (3.6); 4.5194 (1.5); 4.5041 (1.5); 4.4797 (8.0); 4.4639 (14.8); 4.4483 (7.9); 4.4235 (1.5); 4.4087 (1.4); 4.3672 (12.7); 4.3423 (13.5); 3.6248 (15.0); 3.6000 (14.1); 3.0962 (11.7); 3.0546 (13.4); 2.5431 (14.9); 2.5016 (13.0); 2.3141 (0.7); 2.3059 (0.6); 2.2632 (1.5); 2.0409 (1.3); 1.6433 (10.2); 1.5486 (66.9); 1.3286 (1.1); 1.2812 (1.7); 1.2747 (0.6); 1.2569 (3.7); 1.2390 (0.5); 0.8799 (0.7); 0.0079 (1.6); 0.0063 (0.6); -0.0002 (53.1); -0.0085 (1.5) I.2-145: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1134 (3.0); 8.1119 (3.0); 8.1002 (3.0); 8.0988 (3.1); 7.5874 (12.6); 7.5829 (13.0); 7.5189 (0.8); 7.2601 (135.1); 7.1607 (3.2); 7.1561 (5.9); 7.1516 (3.0); 6.9961 (0.8); 6.7371 (2.1); 6.7333 (2.2); 6.7239 (2.0); 6.7201 (2.1); 6.5877 (2.9); 6.5860 (3.7); 6.5841 (3.6); 6.5823 (2.8); 5.9868 (0.8); 4.4587 (2.5); 4.4513 (2.6); 4.4440 (2.5); 4.4366 (2.5); 4.3387 (3.1); 4.3143 (3.3); 4.2620 (4.9); 4.2451 (10.4); 4.2282 (5.0); 3.5727 (3.6); 3.5484 (3.4); 3.1391 (3.1); 3.0972 (3.5); 2.5458 (4.0); 2.5039 (3.5); 2.1316 (0.9); 2.0955 (2.2); 2.0426 (2.2); 1.8337 (0.6); 1.8151 (2.1); 1.7981 (4.2); 1.7796 (4.4); 1.7625 (2.2); 1.7442 (0.6); 1.5432 (19.7); 1.4236 (0.5); 1.2760 (0.8); 1.2581 (2.1); 1.2402 (0.7); 1.0364 (7.8); 1.0179 (16.0); 0.9993 (7.0); 0.0080 (1.6); 0.0065 (0.6); 0.0055 (0.6); -0.0002 (50.7); -0.0066 (0.7); -0.0085 (1.5) I.2-146: 1H-NMR (400.0 MHz, CDCl3): δ= 8.0981 (3.9); 8.0968 (3.8); 8.0849 (3.9); 8.0836 (3.9); 7.5884 (15.6); 7.5838 (16.0); 7.5188 (1.1); 7.2599 (197.9); 7.1615 (4.0); 7.1570 (7.5); 7.1525 (3.8); 6.9959 (1.1); 6.7299 (2.6); 6.7262 (2.7); 6.7167 (2.5); 6.7130 (2.6); 6.5474 (3.6); 6.5457 (4.6); 6.5438 (4.5); 6.5421 (3.4); 5.9735 (1.0); 5.1931 (1.7); 5.1910 (1.1); 5.1757 (2.3); 5.1735 (2.3); 5.1582 (1.1); 5.1561 (1.7); 5.1539 (1.1); 4.4514 (3.2); 4.4444 (3.3); 4.4366 (3.2); 4.4296 (3.1); 4.3370 (4.0); 4.3126 (4.2); 4.1295 (0.7); 4.1117 (0.7); 3.5710 (4.6); 3.5467 (4.3); 3.1375 (3.9); 3.0956 (4.4); 2.5438 (5.0); 2.5019 (4.4); 2.4878 (0.9); 2.4811 (1.2); 2.4740 (0.9); 2.4703 (1.1); 2.4677 (1.3); 2.4638 (1.9); 2.4608 (1.7); 2.4572 (2.0); 2.4504 (2.0); 2.4436 (2.1); 2.4399 (1.8); 2.4370 (2.2); 2.4331 (1.4); 2.4306 (1.3); 2.4267 (1.0); 2.4195 (1.4); 2.4131 (1.0); 2.1731 (0.5); 2.1522 (1.0); 2.1475 (2.1); 2.1406 (1.4); 2.1325 (1.0); 2.1281 (2.1); 2.1234 (2.1); 2.1214 (2.1); 2.1167 (1.8); 2.1040 (1.5); 2.0968 (2.4); 2.0926 (1.0); 2.0794 (0.6); 2.0732 (0.6); 2.0427 (3.4); 1.8492 (0.9); 1.8460 (1.3); 1.8434 (1.0); 1.8393 (0.6); 1.8265 (0.7); 1.8242 (0.8); 1.8214 (1.3); 1.8188 (1.1); 1.7299 (0.5); 1.7097 (1.0); 1.7037 (0.8); 1.6894 (0.6); 1.6842 (1.9); 1.6790 (0.8); 1.6633 (0.8); 1.6588 (1.1); 1.6568 (1.5); 1.6370 (0.6); 1.6314 (0.7); 1.5420 (30.2); 1.2839 (0.5); 1.2760 (1.1); 1.2582 (2.8); 1.2403 (1.0); 0.0080 (2.6); -0.0002 (78.9); -0.0085 (2.4) I.2-147: 1H-NMR (400.0 MHz, CDCl3): δ= 8.4829 (10.6); 8.4702 (10.8); 7.5184 (4.5); 7.3099 (1.8); 7.2961 (1.2); 7.2767 (7.4); 7.2709 (10.2); 7.2596 (841.7); 7.2536 (10.2); 7.2489 (4.4); 7.2473 (6.3); 7.2417 (1.4); 7.2361 (0.9); 7.2282 (0.7); 7.2257 (0.8); 6.9956 (5.9); 6.9087 (6.6); 6.8959 (6.4); 6.6365 (1.5); 6.6309 (2.5); 6.6252 (1.3); 6.6147 (3.0); 6.6090 (5.0); 6.6032 (2.5); 6.5927 (1.4); 6.5870 (2.6); 6.5813 (1.2); 4.5256 (8.0); 4.5136 (8.0); 4.3192 (5.8); 4.2948 (6.3); 3.5805 (7.0); 3.5561 (6.4); 3.2054 (5.9); 3.1957 (4.8); 3.1772 (15.2); 3.1633 (7.2); 3.1588 (16.0); 3.1405 (4.9); 2.5717 (7.3); 2.5297 (6.5); 2.1011 (0.6); 2.0435 (1.0); 1.5835 (34.8); 1.5642 (10.6); 1.4396 (16.9); 1.4212 (35.9); 1.4028 (16.3); 1.3332 (0.6); 1.2843 (0.9); 1.2767 (0.8); 1.2585 (1.5); 0.1458 (0.9); 0.0079 (9.8); 0.0063 (3.7); 0.0054 (4.1); -0.0002 (313.2); -0.0060 (3.1); -0.0068 (2.5); - 0.0085 (8.9); -0.1496 (0.9) I.2-148: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1075 (1.3); 8.0944 (1.4); 7.5901 (6.2); 7.5856 (6.3); 7.5185 (0.7); 7.2596 (122.2); 7.2537 (0.8); 7.2529 (0.6); 7.1611 (1.5); 7.1566 (2.9); 7.1521 (1.4); 6.9956 (0.7); 6.7117 (0.9); 6.7081 (0.9); 6.6985 (0.8); 6.6949 (0.8); 6.5313 (1.6); 6.5295 (1.5); 5.3196 (1.0); 5.3041 (1.3); 5.2887 (1.0); 4.4476 (1.1); 4.4429 (1.1); 4.4331 (1.1); 4.4283 (1.1); 4.3398 (1.4); 4.3154 (1.5); 3.5717 (1.6); 3.5474 (1.5); 3.1417 (1.3); 3.0998 (1.5); 2.5446 (1.7); 2.5027 (1.5); 2.0427 (1.8); 1.5426 (14.6); 1.3463 (16.0); 1.3308 (15.9); 1.2760 (0.6); 1.2581 (1.4); 1.2403 (0.5); 0.0079 (1.4); 0.0054 (0.5); 0.0046 (0.6); -0.0002 (45.4); -0.0027 (2.4); -0.0052 (0.6); -0.0085 (1.3) I.2-149: 1H-NMR (400.0 MHz, CDCl3): δ= 8.4536 (7.5); 8.4411 (7.6); 7.5944 (15.8); 7.5899 (16.0); 7.5186 (1.6); 7.2930 (0.9); 7.2597 (286.6); 7.1540 (4.1); 7.1495 (7.6); 7.1450 (3.9); 6.9957 (1.9); 6.9158 (1.5); 6.8519 (5.4); 6.8395 (5.3); 5.3165 (1.1); 5.3010 (2.8); 5.2855 (3.9); 5.2700 (2.9); 5.2544 (1.1); 4.5137 (9.4); 4.5016 (9.1); 4.3235 (4.7); 4.2993 (4.9); 4.1303 (0.6); 4.1123 (0.6); 3.5778 (5.3); 3.5535 (5.0); 3.1889 (4.6); 3.1467 (5.1); 2.5679 (5.9); 2.5494 (0.6); 2.5258 (5.1); 2.2832 (0.9); 2.2604 (0.5); 2.1940 (0.9); 2.1336 (2.7); 2.1008 (1.2); 2.0432 (2.8); 1.5720 (25.5); 1.5434 (11.9); 1.4392 (2.0); 1.4283 (25.1); 1.4128 (24.7); 1.3328 (1.0); 1.2841 (1.8); 1.2763 (1.6); 1.2586 (6.9); 1.2407 (1.3); 0.8970 (1.0); 0.8804 (2.5); 0.8628 (1.2); 0.8311 (0.7); 0.0080 (3.7); -0.0002 (112.2); -0.0085 (3.6) I.2-150: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1318 (12.7); 8.1185 (12.7); 7.5181 (9.6); 7.2592 (1670.0); 7.2417 (16.3); 7.2361 (11.8); 7.2095 (2.1); 7.0964 (84.4); 7.0810 (51.0); 6.9952 (9.4); 6.8758 (8.9); 6.8592 (8.0); 6.7618 (14.9); 6.6444 (3.0); 6.6388 (4.7); 6.6228 (5.4); 6.6169 (8.9); 6.6116 (4.7); 6.5952 (4.8); 6.0423 (3.6); 4.5259 (9.9); 4.5124 (16.0); 4.4978 (9.0); 4.3344 (12.5); 4.3098 (13.0); 4.1306 (3.6); 4.1125 (3.3); 3.5821 (14.4); 3.5577 (12.9); 3.1378 (11.9); 3.0961 (13.4); 2.5712 (15.4); 2.5296 (13.1); 2.0433 (15.1); 2.0043 (2.0); 1.5579 (71.3); 1.5323 (327.0); 1.3330 (2.1); 1.2763 (4.7); 1.2585 (10.4); 1.2408 (4.2); 0.1463 (2.7); 0.0080 (31.6); -0.0002 (649.8); -0.0085 (27.5); -0.1497 (3.0) I.2-151: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1343 (3.4); 8.1212 (3.4); 7.5906 (15.5); 7.5861 (16.0); 7.5181 (3.7); 7.3496 (1.1); 7.3106 (0.8); 7.2938 (1.2); 7.2903 (0.7); 7.2871 (0.9); 7.2752 (1.9); 7.2744 (1.9); 7.2736 (2.1); 7.2728 (2.2); 7.2704 (3.0); 7.2687 (4.2); 7.2680 (4.7); 7.2672 (5.2); 7.2593 (645.7); 7.2527 (4.4); 7.2519 (3.3); 7.2510 (2.4); 7.2502 (1.9); 7.2494 (1.7); 7.2486 (1.7); 7.2478 (1.5); 7.2470 (1.2); 7.2462 (1.1); 7.2454 (0.8); 7.2446 (0.8); 7.2438 (0.7); 7.2430 (0.5); 7.2093 (3.5); 7.1632 (3.8); 7.1588 (7.8); 7.1542 (3.6); 7.1396 (1.0); 7.0979 (27.8); 7.0815 (14.0); 6.9952 (3.6); 6.8758 (2.1); 6.8625 (2.1); 6.7611 (4.0); 6.0465 (0.9); 4.5238 (2.2); 4.5106 (3.5); 4.4971 (2.2); 4.3402 (3.5); 4.3157 (3.8); 4.1482 (0.5); 4.1303 (1.6); 4.1125 (1.7); 4.0945 (0.5); 3.5848 (4.2); 3.5604 (3.9); 3.1284 (3.4); 3.0865 (3.7); 2.5649 (4.2); 2.5230 (3.6); 2.1350 (1.2); 2.0989 (1.5); 2.0431 (8.0); 1.5523 (25.0); 1.4392 (0.7); 1.4250 (0.7); 1.2840 (0.5); 1.2763 (2.4); 1.2584 (5.4); 1.2406 (2.3); 0.1571 (0.6); 0.1458 (0.7); 0.0159 (0.5); 0.0151 (0.5); 0.0135 (0.6); 0.0127 (0.7); 0.0119 (0.8); 0.0080 (7.9); 0.0064 (2.7); 0.0055 (3.0); 0.0047 (3.5); -0.0002 (250.2); -0.0067 (2.9); -0.0085 (7.4); -0.0501 (1.5); -0.1495 (0.8) I.2-152: 1H-NMR (400.0 MHz, CDCl3): δ= 7.7496 (12.3); 7.7037 (5.6); 7.4379 (0.5); 7.4205 (1.5); 7.4018 (1.3); 7.3809 (0.7); 7.3631 (0.7); 7.3020 (0.6); 7.2979 (0.6); 7.2895 (2.2); 7.2813 (1.6); 7.2749 (4.5); 7.2717 (4.7); 7.2598 (62.0); 7.1850 (4.2); 7.1654 (3.5); 7.1616 (2.7); 5.3602 (1.5); 5.3570 (1.6); 5.2846 (0.8); 4.8147 (1.7); 4.7782 (1.9); 4.6590 (0.6); 4.6172 (1.0); 4.5167 (1.1); 4.4751 (0.6); 4.3674 (2.6); 4.3534 (2.2); 4.3170 (1.8); 4.2413 (1.4); 3.4889 (0.8); 3.2271 (4.0); 3.1932 (1.9); 2.9746 (1.5); 2.9609 (9.4); 2.9515 (16.0); 2.9379 (0.9); 2.9253 (0.8); 2.7717 (0.5); 2.7655 (0.6); 2.7596 (0.6); 2.7535 (0.7); 2.7475 (0.6); 1.8688 (4.7); 1.8642 (6.5); 1.8590 (4.6); 1.7485 (2.5); 1.7439 (3.5); 1.7391 (2.4); 1.5557 (3.8); 1.2048 (6.5); 1.1866 (6.4); 1.1433 (3.3); 1.1251 (3.2); 0.0080 (0.8); -0.0002 (23.6); -0.0085 (0.7) I.2-153: 1H-NMR (400.0 MHz, CDCl3): δ= 7.7081 (0.6); 7.6862 (16.0); 7.2611 (75.9); 6.6132 (0.7); 5.3506 (1.9); 4.5333 (2.7); 4.4471 (1.6); 3.5554 (1.1); 3.5462 (1.3); 3.5380 (1.2); 3.5295 (1.2); 3.4893 (2.7); 3.0063 (4.9); 2.7471 (0.6); 1.8541 (6.2); 1.8497 (8.1); 1.8441 (5.9); 1.3093 (4.8); 1.2912 (9.9); 1.2730 (4.8); 1.1800 (5.6); 1.1618 (5.5); 0.0080 (0.8); -0.0002 (29.0); -0.0085 (0.9) I.2-154: 1H-NMR (400.0 MHz, CDCl3): δ= 8.0493 (0.5); 8.0281 (0.6); 7.6706 (0.5); 7.5454 (1.0); 7.5409 (1.0); 7.5199 (1.8); 7.5142 (8.6); 7.5098 (9.0); 7.4902 (0.7); 7.4352 (0.5); 7.4315 (0.6); 7.2611 (114.7); 7.1132 (1.2); 7.1087 (1.8); 7.1041 (2.0); 6.9971 (0.7); 6.2263 (3.6); 5.3427 (2.3); 4.5394 (3.1); 4.4511 (1.8); 3.5589 (1.4); 3.5439 (1.8); 3.5280 (1.6); 3.5103 (1.0); 3.4889 (3.8); 3.0062 (4.2); 2.7462 (0.8); 1.9322 (0.6); 1.9279 (0.8); 1.9224 (0.6); 1.8424 (7.4); 1.8370 (10.1); 1.8324 (7.9); 1.5646 (0.8); 1.3094 (7.7); 1.2912 (16.0); 1.2731 (8.0); 1.2585 (1.3); 1.2479 (0.9); 1.2250 (0.7); 1.2088 (1.0); 1.1820 (5.2); 1.1639 (5.2); 0.0080 (1.0); -0.0002 (44.7); - 0.0085 (1.7) I.2-155: 1H-NMR (400.0 MHz, CDCl3): δ= 8.2917 (1.6); 8.2791 (1.6); 7.6849 (16.0); 7.5189 (0.5); 7.2600 (94.6); 7.1345 (2.4); 7.0376 (1.4); 7.0342 (1.3); 7.0249 (1.4); 7.0214 (1.3); 6.9960 (0.5); 6.1709 (0.7); 5.3667 (1.5); 5.3636 (1.5); 4.5395 (2.4); 4.4676 (1.5); 4.4523 (1.5); 4.4414 (1.5); 4.4263 (1.5); 3.0025 (3.9); 2.9438 (1.2); 2.9315 (1.4); 2.7743 (0.5); 2.7683 (0.6); 2.7623 (0.6); 2.7561 (0.6); 1.8676 (4.9); 1.8633 (6.4); 1.8620 (6.4); 1.8576 (4.9); 1.5568 (3.7); 1.2023 (7.3); 1.1841 (7.2); 0.0080 (1.2); -0.0002 (37.2); -0.0085 (1.0) I.2-156: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1126 (3.6); 8.1111 (3.6); 8.0994 (3.7); 8.0980 (3.7); 7.5862 (16.0); 7.5817 (16.0); 7.5186 (1.2); 7.2727 (0.8); 7.2597 (218.9); 7.2101 (0.6); 7.1633 (4.0); 7.1588 (7.5); 7.1543 (3.8); 6.9957 (1.2); 6.8649 (2.5); 6.8613 (2.6); 6.8517 (2.4); 6.8481 (2.4); 6.7258 (3.4); 6.7241 (4.3); 6.7224 (4.3); 6.7206 (3.2); 6.0378 (0.9); 4.7958 (2.9); 4.7744 (9.3); 4.7530 (9.6); 4.7316 (3.2); 4.4954 (2.7); 4.4820 (3.9); 4.4686 (2.7); 4.3390 (3.8); 4.3146 (4.0); 4.1295 (1.0); 4.1117 (1.0); 3.5814 (4.4); 3.5571 (4.2); 3.1337 (3.6); 3.0918 (4.2); 2.5579 (4.7); 2.5161 (4.1); 2.0961 (0.6); 2.0427 (4.6); 1.5539 (25.0); 1.2760 (1.6); 1.2581 (3.6); 1.2403 (1.4); 0.8818 (0.6); 0.0079 (2.4); 0.0063 (0.8); 0.0054 (0.9); -0.0002 (82.2); -0.0068 (1.0); - 0.0085 (2.5) I.2-157: 1H-NMR (400.0 MHz, CDCl3): δ= 8.1716 (3.6); 8.1702 (3.6); 8.1589 (3.7); 8.1574 (3.6); 7.5832 (15.9); 7.5787 (16.0); 7.5186 (1.6); 7.2840 (0.6); 7.2597 (296.4); 7.2098 (0.6); 7.1627 (3.9); 7.1581 (7.4); 7.1536 (3.7); 6.9957 (1.6); 6.5399 (2.4); 6.5366 (2.8); 6.5271 (2.3); 6.5238 (2.7); 6.4966 (4.6); 5.9512 (1.0); 4.4158 (5.5); 4.4012 (5.4); 4.3369 (4.0); 4.3125 (4.2); 4.1300 (1.0); 4.1122 (1.0); 3.8271 (8.4); 3.8151 (9.7); 3.8025 (9.7); 3.5698 (4.7); 3.5455 (4.5); 3.5100 (9.3); 3.4974 (9.1); 3.4854 (7.9); 3.1183 (4.0); 3.0763 (4.6); 2.5478 (5.1); 2.5059 (4.4); 2.0736 (10.5); 2.0430 (4.8); 1.6917 (0.6); 1.5846 (0.6); 1.5298 (21.4); 1.4288 (0.6); 1.4125 (0.6); 1.3327 (0.7); 1.2840 (0.9); 1.2762 (1.6); 1.2583 (4.1); 1.2405 (1.5); 0.0080 (3.5); 0.0055 (1.4); - 0.0002 (116.3); -0.0067 (1.6); -0.0085 (3.6) I.2-158: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6611 (1.1); 8.6467 (2.2); 8.6331 (1.1); 7.7180 (1.0); 7.7100 (9.8); 7.7045 (3.0); 7.6929 (3.2); 7.6873 (11.7); 7.6793 (1.2); 7.4610 (2.8); 7.4578 (2.2); 7.4432 (5.5); 7.4382 (16.0); 7.4326 (4.8); 7.4209 (3.2); 7.4154 (11.0); 7.4108 (2.2); 7.3799 (1.0); 7.3741 (1.7); 7.3612 (3.6); 7.3567 (6.1); 7.3530 (3.9); 7.3481 (2.1); 7.3395 (6.1); 7.3353 (4.3); 7.3259 (4.6); 7.3219 (3.8); 7.3190 (3.4); 7.3077 (3.2); 7.3014 (2.5); 7.2962 (1.3); 7.2899 (1.9); 7.2838 (1.0); 7.2769 (1.0); 7.2713 (0.9); 6.6088 (0.9); 6.5930 (0.5); 4.3885 (7.4); 4.3741 (7.3); 4.3073 (3.0); 4.2921 (3.0); 4.0547 (2.0); 4.0331 (3.1); 4.0305 (3.5); 4.0090 (2.9); 3.9202 (2.9); 3.9052 (3.1); 3.8959 (2.1); 3.8808 (2.3); 3.3877 (0.5); 3.3653 (1.1); 3.3483 (1.7); 3.3321 (1.2); 3.3130 (31.9); 2.8194 (2.0); 2.7962 (1.9); 2.7770 (4.0); 2.7537 (3.7); 2.7133 (4.0); 2.6954 (3.7); 2.6708 (2.1); 2.6530 (1.8); 2.5232 (1.3); 2.5184 (1.9); 2.5098 (23.8); 2.5052 (51.3); 2.5006 (71.1); 2.4960 (49.8); 2.4915 (22.6); 2.0852 (1.0); 2.0726 (1.0); 0.0080 (0.7); -0.0002 (21.6); -0.0085 (0.7) I.2-159: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6886 (1.3); 8.6749 (2.7); 8.6609 (1.4); 7.7131 (1.2); 7.7050 (11.0); 7.6995 (3.5); 7.6878 (3.7); 7.6823 (13.4); 7.6743 (1.5); 7.6200 (8.0); 7.6149 (8.5); 7.4424 (4.0); 7.4379 (16.0); 7.4324 (4.2); 7.4215 (8.8); 7.4158 (14.9); 7.4073 (1.3); 7.3880 (7.8); 7.3673 (3.6); 4.3579 (7.8); 4.3436 (7.7); 4.0470 (2.3); 4.0253 (3.6); 4.0227 (3.9); 4.0012 (3.1); 3.9096 (3.2); 3.8944 (3.4); 3.8852 (2.5); 3.8703 (2.5); 3.3764 (0.6); 3.3549 (1.2); 3.3378 (2.2); 3.3150 (48.9); 2.8146 (2.2); 2.7914 (2.2); 2.7722 (4.4); 2.7489 (4.0); 2.7038 (4.4); 2.6859 (4.1); 2.6613 (2.3); 2.6435 (2.0); 2.5236 (2.4); 2.5102 (37.8); 2.5056 (80.0); 2.5010 (110.0); 2.4964 (76.6); 2.4918 (34.5); 2.3278 (0.6); 2.0855 (1.5); 2.0731 (4.0); -0.0002 (6.2) I.2-160: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6770 (1.3); 8.6624 (2.5); 8.6477 (1.3); 7.7140 (1.2); 7.7059 (12.4); 7.7004 (3.8); 7.6887 (3.9); 7.6831 (15.0); 7.6751 (1.6); 7.4439 (1.4); 7.4359 (16.0); 7.4304 (4.3); 7.4187 (4.0); 7.4132 (13.1); 7.4050 (2.2); 7.3985 (10.0); 7.3934 (3.6); 7.3823 (4.3); 7.3771 (16.0); 7.3709 (2.2); 7.3100 (1.7); 7.3039 (12.0); 7.2986 (3.4); 7.2874 (2.8); 7.2823 (7.7); 4.3030 (8.1); 4.2883 (8.1); 4.0343 (2.6); 4.0127 (3.8); 4.0102 (4.4); 3.9886 (3.6); 3.9012 (3.7); 3.8860 (3.9); 3.8770 (2.7); 3.8618 (2.8); 3.3356 (0.8); 3.3121 (54.3); 3.3026 (1.8); 3.2967 (2.2); 3.2803 (1.5); 3.2759 (1.2); 3.2574 (0.6); 2.8005 (2.5); 2.7773 (2.3); 2.7581 (5.2); 2.7348 (4.7); 2.6955 (5.1); 2.6775 (4.8); 2.6699 (0.8); 2.6531 (2.3); 2.6350 (2.3); 2.5233 (1.8); 2.5185 (2.6); 2.5099 (38.4); 2.5053 (84.1); 2.5007 (118.2); 2.4960 (82.7); 2.4914 (37.2); 2.3275 (0.7); 2.3229 (0.5); -0.0002 (7.1) I.2-161: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5536 (0.6); 7.7055 (2.8); 7.7000 (0.9); 7.6883 (0.9); 7.6827 (3.4); 7.4339 (3.5); 7.4283 (1.0); 7.4166 (0.9); 7.4112 (3.1); 7.2038 (2.1); 7.1985 (0.7); 7.1873 (0.7); 7.1819 (2.4); 6.8975 (3.0); 6.8921 (0.9); 6.8809 (0.8); 6.8757 (2.6); 4.2411 (1.9); 4.2266 (1.9); 4.0226 (0.6); 4.0009 (0.9); 3.9984 (1.0); 3.9769 (0.8); 3.8915 (0.8); 3.8763 (0.9); 3.8672 (0.6); 3.8521 (0.6); 3.7290 (16.0); 3.3144 (6.9); 2.7850 (0.5); 2.7426 (1.2); 2.7194 (1.1); 2.6863 (1.2); 2.6683 (1.1); 2.6439 (0.5); 2.5097 (5.2); 2.5052 (11.3); 2.5005 (15.7); 2.4959 (11.0); 2.4913 (5.0); -0.0002 (0.9) I.2-164: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6635 (0.8); 8.6483 (1.5); 8.6324 (0.8); 7.5306 (5.6); 7.5260 (1.9); 7.5142 (2.0); 7.5093 (6.6); 7.4047 (0.6); 7.3983 (5.8); 7.3932 (2.1); 7.3822 (2.5); 7.3769 (9.5); 7.3707 (1.3); 7.3029 (6.9); 7.2976 (2.0); 7.2864 (1.7); 7.2813 (4.5); 7.1809 (4.8); 7.1604 (4.3); 4.3031 (4.8); 4.2882 (4.8); 4.0084 (1.5); 3.9866 (2.3); 3.9841 (2.6); 3.9624 (2.1); 3.8801 (2.2); 3.8647 (2.3); 3.8558 (1.6); 3.8404 (1.7); 3.3118 (41.0); 3.2854 (1.2); 3.2678 (0.9); 2.7637 (1.3); 2.7405 (1.1); 2.7215 (3.0); 2.6982 (2.8); 2.6747 (3.3); 2.6563 (2.9); 2.6326 (1.2); 2.6141 (1.2); 2.5228 (1.5); 2.5182 (2.1); 2.5095 (28.3); 2.5049 (61.7); 2.5003 (86.1); 2.4957 (60.2); 2.4911 (27.0); 2.2757 (16.0); -0.0002 (5.4) I.2-166: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5395 (1.2); 7.5299 (4.3); 7.5084 (4.9); 7.2396 (4.6); 7.2207 (3.5); 7.2154 (2.8); 7.2082 (2.9); 7.1813 (3.7); 7.1609 (3.4); 4.2847 (3.7); 4.2704 (3.6); 4.0219 (1.2); 3.9979 (1.9); 3.9762 (1.6); 3.8806 (1.6); 3.8655 (1.7); 3.8563 (1.2); 3.8412 (1.2); 3.3287 (0.8); 3.3119 (44.2); 2.7763 (1.1); 2.7530 (1.0); 2.7342 (2.1); 2.7108 (2.0); 2.6662 (2.5); 2.6482 (2.0); 2.6241 (1.0); 2.6061 (1.1); 2.5095 (31.0); 2.5049 (65.5); 2.5003 (89.5); 2.4957 (62.7); 2.4912 (28.4); 2.3273 (0.5); 2.2755 (12.5); 2.2492 (16.0); -0.0002 (4.6) I.2-173: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5948 (0.5); 8.5812 (1.0); 8.5670 (0.5); 7.3452 (0.7); 7.3406 (0.8); 7.3194 (0.9); 7.3142 (0.8); 7.1915 (0.9); 7.1878 (1.0); 7.1790 (0.9); 7.1757 (1.1); 7.1711 (0.6); 7.1676 (0.7); 7.1587 (0.7); 7.1560 (0.8); 7.1433 (1.0); 7.1287 (1.2); 7.1255 (1.0); 7.1097 (0.5); 4.3616 (2.8); 4.3476 (2.9); 4.3009 (0.7); 4.2821 (1.0); 4.2627 (0.7); 3.5234 (1.2); 3.4999 (2.0); 3.4779 (1.6); 3.3445 (1.5); 3.3291 (1.7); 3.3207 (1.2); 3.3052 (1.3); 3.1411 (0.6); 3.1374 (0.6); 3.1257 (0.6); 3.1196 (0.9); 3.1153 (0.6); 3.1030 (0.6); 2.5106 (8.0); 2.5060 (18.0); 2.5014 (25.8); 2.4968 (18.6); 2.4922 (8.8); 2.4818 (1.3); 2.4585 (0.9); 2.4403 (2.6); 2.4170 (2.4); 2.4045 (2.6); 2.3858 (2.4); 2.3631 (0.9); 2.3444 (0.8); 2.0857 (16.0); 1.6807 (0.8); 1.6740 (1.0); 1.6566 (1.1); 1.6445 (1.6); 1.6353 (1.4); 1.6313 (1.4); 1.6264 (1.4); 1.6165 (0.9); 1.5357 (0.7); 1.5265 (1.1); 1.5171 (1.4); 1.5072 (2.0); 1.4920 (1.4); 1.4827 (1.1); 1.4706 (0.8); 1.4624 (0.6); -0.0002 (2.6) I.2-174: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4693 (0.5); 8.4557 (1.0); 8.4414 (0.5); 7.2354 (0.5); 7.2301 (0.6); 7.2162 (1.4); 7.2104 (4.6); 7.2042 (5.0); 7.2026 (5.7); 7.1817 (0.8); 4.2616 (1.7); 4.2498 (2.2); 4.2368 (1.7); 3.5437 (1.3); 3.5216 (2.2); 3.5197 (2.4); 3.4976 (3.2); 3.4791 (3.8); 3.3850 (1.6); 3.3704 (1.8); 3.3610 (1.2); 3.3463 (1.4); 3.1946 (0.5); 3.1899 (0.6); 3.1799 (0.5); 3.1727 (0.8); 3.1575 (0.6); 3.0298 (0.7); 3.0104 (0.8); 2.9967 (1.5); 2.9771 (1.6); 2.9430 (1.4); 2.9250 (1.5); 2.9097 (0.7); 2.8917 (0.7); 2.5234 (0.7); 2.5188 (1.0); 2.5101 (19.3); 2.5055 (42.6); 2.5009 (60.1); 2.4962 (42.1); 2.4916 (18.7); 2.4699 (2.0); 2.4466 (2.0); 2.4390 (2.1); 2.4211 (1.9); 2.3976 (0.7); 2.3797 (0.5); 2.2372 (16.0); 1.8551 (0.7); 1.8377 (0.9); 1.8200 (0.7); 0.8239 (9.1); 0.8070 (10.7); 0.8051 (11.2); 0.7883 (9.0); 0.0080 (0.7); -0.0002 (29.8); -0.0085 (0.9) I.2-175: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5627 (1.6); 8.5479 (3.0); 8.5337 (1.6); 7.3064 (5.6); 7.3009 (2.3); 7.2925 (6.4); 7.2843 (8.1); 7.2761 (2.8); 7.2704 (7.6); 7.2629 (0.8); 7.1794 (1.2); 7.1720 (10.2); 7.1665 (2.8); 7.1555 (3.0); 7.1496 (16.0); 7.1438 (3.0); 7.1328 (2.5); 7.1273 (7.3); 7.1198 (0.7); 4.4869 (0.7); 4.4667 (1.7); 4.4430 (3.4); 4.4231 (1.9); 4.3992 (0.8); 4.2738 (9.8); 4.2590 (9.7); 3.6510 (3.6); 3.6277 (6.3); 3.6051 (4.8); 3.4492 (4.6); 3.4331 (5.2); 3.4253 (3.8); 3.4093 (4.2); 3.3493 (29.5); 3.1617 (1.0); 3.1456 (1.3); 3.1395 (2.2); 3.1231 (2.3); 3.1197 (2.7); 3.1032 (2.3); 3.0972 (1.4); 3.0810 (1.0); 2.6744 (0.9); 2.6699 (1.3); 2.6653 (0.9); 2.5233 (4.0); 2.5186 (5.7); 2.5100 (74.4); 2.5054 (161.6); 2.5008 (225.3); 2.4961 (155.9); 2.4916 (68.6); 2.4622 (2.0); 2.4555 (1.4); 2.4507 (1.8); 2.4435 (9.4); 2.4284 (9.2); 2.4206 (8.8); 2.4085 (8.5); 2.3868 (1.8); 2.3669 (1.4); 2.3322 (1.2); 2.3276 (1.5); 2.3229 (1.1); 2.2239 (0.5); 2.1994 (1.7); 2.1949 (1.6); 2.1809 (2.2); 2.1751 (3.1); 2.1706 (3.2); 2.1637 (1.3); 2.1560 (2.9); 2.1517 (3.7); 2.1462 (3.0); 2.1320 (1.8); 2.1276 (2.7); 2.1031 (0.8); 2.0033 (1.4); 1.9926 (2.2); 1.9876 (2.4); 1.9805 (2.8); 1.9754 (3.1); 1.9687 (3.4); 1.9600 (3.2); 1.9488 (2.2); 1.9439 (2.0); 1.9328 (1.2); 1.6546 (1.2); 1.6484 (1.0); 1.6384 (3.5); 1.6295 (2.6); 1.6249 (3.4); 1.6140 (6.5); 1.6007 (3.7); 1.5894 (2.9); 1.5748 (1.1); 0.0080 (2.8); 0.0063 (1.0); 0.0055 (1.1); 0.0046 (1.3); -0.0002 (90.0); -0.0052 (1.2); -0.0060 (0.9); -0.0068 (0.8); - 0.0085 (2.6) I.2-176: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5589 (1.6); 8.5446 (3.0); 8.5302 (1.6); 7.3547 (0.6); 7.3500 (2.5); 7.3475 (4.8); 7.3440 (1.6); 7.3356 (2.7); 7.3338 (2.4); 7.3289 (8.3); 7.3264 (10.1); 7.3185 (2.2); 7.3110 (11.8); 7.3064 (2.2); 7.2621 (14.4); 7.2607 (16.0); 7.2532 (3.2); 7.2492 (2.5); 7.2438 (11.0); 7.2399 (6.3); 7.2381 (5.8); 7.2329 (0.9); 7.2298 (1.4); 7.2261 (2.0); 7.2226 (0.9); 4.4902 (0.7); 4.4703 (1.8); 4.4666 (1.8); 4.4466 (3.5); 4.4266 (2.0); 4.4226 (1.9); 4.4027 (0.9); 4.2970 (10.9); 4.2822 (10.8); 4.2586 (0.6); 4.2436 (0.7); 4.2321 (0.6); 4.1315 (1.0); 3.6588 (3.8); 3.6353 (6.5); 3.6129 (5.1); 3.4603 (4.7); 3.4442 (5.2); 3.4364 (3.8); 3.4204 (4.2); 3.1753 (1.0); 3.1592 (1.3); 3.1533 (2.4); 3.1389 (2.2); 3.1369 (2.5); 3.1331 (2.9); 3.1168 (2.5); 3.1108 (1.4); 3.0947 (1.0); 2.5233 (0.7); 2.5186 (1.2); 2.5099 (18.7); 2.5053 (41.2); 2.5007 (57.6); 2.4961 (40.3); 2.4915 (19.1); 2.4685 (1.3); 2.4496 (9.6); 2.4381 (9.3); 2.4269 (9.0); 2.4180 (8.9); 2.3964 (1.5); 2.3764 (1.1); 2.2277 (0.5); 2.2102 (0.8); 2.2031 (1.6); 2.1987 (1.5); 2.1925 (0.8); 2.1854 (2.2); 2.1813 (2.4); 2.1785 (2.8); 2.1743 (3.2); 2.1679 (1.4); 2.1610 (2.9); 2.1570 (3.4); 2.1545 (2.7); 2.1500 (3.0); 2.1434 (1.1); 2.1370 (1.8); 2.1327 (2.6); 2.1257 (1.2); 2.1082 (0.8); 2.0054 (1.3); 1.9947 (2.2); 1.9891 (2.2); 1.9864 (2.2); 1.9823 (2.6); 1.9765 (3.4); 1.9710 (3.5); 1.9652 (3.1); 1.9615 (3.2); 1.9571 (2.7); 1.9511 (2.3); 1.9461 (2.0); 1.9415 (1.4); 1.9351 (1.0); 1.6554 (1.2); 1.6481 (0.9); 1.6393 (3.6); 1.6303 (2.7); 1.6261 (3.5); 1.6150 (6.6); 1.6017 (3.6); 1.5904 (3.0); 1.5788 (0.9); 1.5756 (1.0); -0.0002 (5.8) I.2-177: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4635 (0.5); 7.1850 (2.0); 7.1797 (0.6); 7.1685 (0.7); 7.1631 (2.3); 6.8958 (2.9); 6.8904 (0.8); 6.8792 (0.8); 6.8739 (2.5); 4.4424 (0.6); 4.2182 (1.9); 4.2036 (1.9); 3.7275 (16.0); 3.6413 (0.6); 3.6181 (1.0); 3.5955 (0.8); 3.4417 (0.7); 3.4256 (0.8); 3.4179 (0.6); 3.4018 (0.6); 2.5101 (2.8); 2.5055 (6.2); 2.5008 (8.6); 2.4962 (6.0); 2.4916 (2.6); 2.4318 (1.5); 2.4219 (1.5); 2.4092 (1.4); 2.4017 (1.4); 2.1529 (0.6); 1.9734 (0.6); 1.9692 (0.5); 1.9581 (0.5); 1.6373 (0.6); 1.6239 (0.5); 1.6129 (1.0); 1.5995 (0.6); -0.0002 (1.0) I.2-178: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5905 (1.3); 8.5758 (2.6); 8.5611 (1.3); 7.4038 (1.2); 7.3974 (10.8); 7.3924 (3.6); 7.3812 (4.4); 7.3760 (16.0); 7.3698 (1.9); 7.2901 (1.7); 7.2840 (12.3); 7.2787 (3.4); 7.2675 (3.0); 7.2624 (8.3); 7.2562 (0.8); 4.4878 (0.5); 4.4679 (1.4); 4.4644 (1.4); 4.4441 (2.7); 4.4241 (1.5); 4.4201 (1.4); 4.4004 (0.6); 4.2803 (8.6); 4.2655 (8.5); 3.6543 (4.7); 3.6311 (7.0); 3.6085 (4.8); 3.4516 (3.7); 3.4356 (4.0); 3.4277 (3.0); 3.4117 (3.2); 3.1695 (0.8); 3.1533 (1.0); 3.1494 (1.6); 3.1473 (1.7); 3.1335 (1.6); 3.1307 (1.8); 3.1276 (2.2); 3.1112 (1.8); 3.1050 (1.1); 3.0889 (0.8); 2.5240 (0.7); 2.5194 (1.0); 2.5107 (13.8); 2.5061 (30.2); 2.5014 (42.1); 2.4968 (29.4); 2.4922 (13.3); 2.4672 (1.2); 2.4485 (7.0); 2.4308 (7.1); 2.4256 (6.6); 2.4111 (6.4); 2.3891 (1.5); 2.3694 (1.2); 2.2002 (1.3); 2.1961 (1.2); 2.1886 (0.6); 2.1805 (1.7); 2.1759 (2.5); 2.1716 (2.4); 2.1643 (1.0); 2.1564 (2.2); 2.1524 (3.0); 2.1474 (2.3); 2.1401 (0.8); 2.1323 (1.4); 2.1282 (2.1); 2.1037 (0.6); 2.0035 (1.0); 1.9925 (1.8); 1.9883 (1.8); 1.9805 (2.2); 1.9766 (2.6); 1.9721 (2.3); 1.9686 (2.6); 1.9644 (2.2); 1.9606 (2.5); 1.9573 (2.4); 1.9522 (1.6); 1.9486 (1.7); 1.9446 (1.6); 1.9327 (1.0); 1.9291 (0.7); 1.6551 (0.9); 1.6477 (0.7); 1.6389 (2.8); 1.6300 (2.1); 1.6256 (2.6); 1.6146 (5.1); 1.6012 (2.8); 1.5899 (2.3); 1.5753 (0.8); -0.0002 (4.7) I.2-179: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5694 (1.4); 8.5553 (2.7); 8.5414 (1.4); 7.4597 (2.8); 7.4568 (5.0); 7.4536 (2.6); 7.4412 (3.7); 7.4389 (7.0); 7.4357 (3.9); 7.3465 (3.4); 7.3428 (7.5); 7.3410 (4.3); 7.3328 (16.0); 7.3301 (13.6); 7.3224 (6.4); 7.3117 (3.1); 7.3096 (1.7); 7.3039 (3.3); 7.2989 (1.2); 7.2929 (2.9); 7.2809 (1.1); 4.4916 (0.6); 4.4720 (1.4); 4.4482 (2.8); 4.4283 (1.5); 4.4243 (1.5); 4.4042 (0.8); 4.3638 (10.2); 4.3493 (10.1); 3.6733 (3.1); 3.6499 (5.3); 3.6275 (4.2); 3.5015 (3.6); 3.4738 (5.4); 3.4579 (5.0); 3.4499 (3.7); 3.4340 (3.8); 3.2194 (0.9); 3.2036 (1.0); 3.1974 (1.7); 3.1839 (1.6); 3.1809 (1.9); 3.1779 (2.2); 3.1616 (1.8); 3.1553 (1.2); 3.1393 (0.8); 2.6744 (0.6); 2.6699 (0.9); 2.6652 (0.6); 2.5234 (1.9); 2.5187 (2.7); 2.5100 (45.9); 2.5054 (102.4); 2.5007 (143.4); 2.4961 (99.2); 2.4915 (43.7); 2.4845 (2.9); 2.4656 (7.6); 2.4557 (1.1); 2.4468 (8.1); 2.4426 (7.4); 2.4273 (6.9); 2.4052 (1.7); 2.3856 (1.3); 2.3322 (0.6); 2.3276 (0.9); 2.3230 (0.7); 2.2073 (1.4); 2.2032 (1.2); 2.1826 (3.0); 2.1789 (2.7); 2.1717 (1.0); 2.1618 (2.4); 2.1583 (3.5); 2.1545 (2.7); 2.1377 (1.4); 2.1339 (2.4); 2.1094 (0.7); 2.0060 (1.0); 1.9950 (2.0); 1.9906 (1.8); 1.9802 (2.8); 1.9750 (2.9); 1.9711 (2.3); 1.9677 (2.1); 1.9647 (2.5); 1.9606 (2.8); 1.9558 (1.8); 1.9504 (1.8); 1.9476 (1.6); 1.9358 (0.9); 1.6578 (1.0); 1.6526 (0.7); 1.6420 (2.9); 1.6327 (2.3); 1.6290 (2.9); 1.6177 (5.3); 1.6044 (2.8); 1.5931 (2.5); 1.5782 (0.9); 0.0080 (1.7); -0.0002 (61.3); -0.0052 (0.6); -0.0085 (1.7) I.2-180: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5511 (0.8); 8.5366 (1.5); 8.5221 (0.8); 7.3014 (3.0); 7.2959 (1.2); 7.2875 (3.1); 7.2793 (4.4); 7.2711 (1.4); 7.2654 (3.7); 7.2578 (0.5); 7.1740 (0.6); 7.1667 (4.9); 7.1611 (1.3); 7.1501 (1.5); 7.1442 (7.7); 7.1384 (1.5); 7.1274 (1.2); 7.1220 (3.6); 4.2699 (4.2); 4.2551 (4.1); 4.0348 (0.7); 3.5247 (1.8); 3.5025 (2.8); 3.5008 (3.1); 3.4787 (2.6); 3.3816 (2.4); 3.3666 (2.7); 3.3574 (1.8); 3.3425 (2.1); 3.3236 (40.5); 3.1784 (0.5); 3.1634 (0.6); 3.1596 (0.9); 3.1562 (1.0); 3.1446 (0.9); 3.1409 (1.1); 3.1376 (1.3); 3.1341 (0.8); 3.1223 (1.1); 3.1191 (0.7); 3.1151 (0.6); 3.0197 (1.0); 3.0003 (1.0); 2.9865 (2.5); 2.9670 (2.6); 2.9474 (2.4); 2.9293 (2.5); 2.9141 (1.0); 2.8960 (1.0); 2.5194 (0.5); 2.5107 (7.7); 2.5061 (17.0); 2.5015 (24.0); 2.4969 (16.7); 2.4923 (7.4); 2.4770 (0.6); 2.4582 (3.2); 2.4517 (0.5); 2.4417 (3.5); 2.4355 (3.2); 2.4229 (3.2); 2.4002 (0.6); 2.3814 (0.5); 1.8688 (0.6); 1.8511 (1.1); 1.8341 (1.4); 1.8170 (1.1); 1.7989 (0.6); 0.8219 (14.1); 0.8084 (16.0); 0.8053 (15.6); 0.7918 (13.8); -0.0002 (2.8) I.2-181: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5982 (2.4); 8.5838 (4.7); 8.5695 (2.4); 7.6185 (15.5); 7.6133 (16.0); 7.4450 (7.3); 7.4396 (6.6); 7.4242 (11.4); 7.4188 (11.0); 7.3573 (13.6); 7.3364 (8.5); 4.4885 (0.9); 4.4689 (2.3); 4.4653 (2.2); 4.4451 (4.4); 4.4251 (2.5); 4.4213 (2.4); 4.4014 (1.0); 4.3339 (14.7); 4.3196 (14.5); 3.6656 (4.8); 3.6421 (8.2); 3.6197 (6.4); 3.4628 (20.1); 3.4473 (14.3); 3.4391 (8.6); 3.4232 (6.8); 3.2100 (1.4); 3.1939 (1.7); 3.1905 (2.4); 3.1877 (2.6); 3.1746 (2.4); 3.1710 (3.0); 3.1686 (3.4); 3.1521 (2.7); 3.1457 (1.8); 3.1297 (1.2); 2.6750 (0.7); 2.6703 (1.0); 2.6658 (0.7); 2.5239 (2.4); 2.5192 (3.4); 2.5105 (50.4); 2.5059 (111.8); 2.5013 (155.8); 2.4966 (108.2); 2.4920 (47.2); 2.4807 (3.2); 2.4621 (11.2); 2.4561 (1.6); 2.4514 (1.8); 2.4466 (1.7); 2.4383 (17.8); 2.4185 (10.3); 2.3962 (2.9); 2.3768 (2.5); 2.3327 (0.7); 2.3281 (1.0); 2.3234 (0.7); 2.2276 (0.7); 2.2027 (2.3); 2.1991 (2.0); 2.1887 (1.4); 2.1781 (4.8); 2.1746 (4.2); 2.1646 (1.6); 2.1568 (3.9); 2.1535 (5.6); 2.1501 (4.4); 2.1431 (1.4); 2.1325 (2.3); 2.1290 (3.7); 2.1045 (1.0); 2.0856 (2.9); 2.0049 (1.4); 1.9928 (3.2); 1.9886 (2.8); 1.9795 (4.1); 1.9738 (4.5); 1.9675 (3.5); 1.9631 (3.8); 1.9598 (4.1); 1.9546 (2.7); 1.9483 (3.0); 1.9347 (1.3); 1.6572 (1.6); 1.6518 (1.2); 1.6411 (4.5); 1.6320 (3.5); 1.6279 (4.5); 1.6168 (8.3); 1.6034 (4.6); 1.5922 (3.8); 1.5774 (1.3); -0.0002 (17.0) I.2-182: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4837 (0.6); 8.4697 (1.1); 8.4562 (0.6); 7.2339 (0.8); 7.2145 (7.1); 7.2070 (3.5); 7.2056 (3.2); 7.1863 (0.6); 4.4657 (0.6); 4.4451 (1.1); 4.4255 (0.6); 4.2630 (2.2); 4.2586 (2.1); 4.2488 (2.2); 4.2443 (2.1); 3.6694 (1.2); 3.6461 (2.0); 3.6237 (1.6); 3.4568 (1.5); 3.4412 (1.6); 3.4327 (1.1); 3.4172 (1.3); 3.3201 (159.6); 3.2704 (1.1); 3.1744 (0.6); 3.1624 (0.6); 3.1563 (0.8); 3.1399 (0.6); 2.6700 (0.5); 2.5235 (1.3); 2.5188 (1.9); 2.5101 (29.1); 2.5055 (63.8); 2.5009 (89.5); 2.4963 (62.3); 2.4917 (27.5); 2.4765 (1.1); 2.4581 (2.9); 2.4514 (0.8); 2.4468 (0.6); 2.4348 (2.4); 2.4257 (2.5); 2.4067 (2.4); 2.3841 (0.8); 2.3651 (0.7); 2.3277 (0.6); 2.2412 (16.0); 2.2042 (0.6); 2.1995 (0.5); 2.1793 (1.2); 2.1754 (1.2); 2.1552 (1.2); 2.1512 (1.6); 2.1311 (0.6); 2.1269 (1.0); 1.9964 (0.7); 1.9843 (0.9); 1.9793 (1.0); 1.9731 (1.1); 1.9672 (1.0); 1.9640 (1.0); 1.9529 (0.7); 1.9481 (0.7); 1.6411 (1.1); 1.6279 (1.1); 1.6167 (2.1); 1.6033 (1.2); 1.5921 (1.0); -0.0002 (1.8) I.3-1: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2398 (5.1); 8.5853 (1.3); 8.1448 (5.0); 8.1417 (5.3); 8.0266 (2.0); 8.0181 (2.2); 8.0111 (3.3); 8.0064 (2.0); 8.0028 (2.2); 7.9969 (2.0); 7.6993 (1.5); 7.6781 (1.9); 7.6664 (7.3); 7.6605 (7.4); 7.6103 (10.0); 7.6081 (9.9); 7.6020 (4.7); 7.5986 (4.7); 7.5948 (5.4); 7.5749 (0.8); 7.4210 (4.5); 7.4149 (4.2); 7.3993 (3.8); 7.3933 (3.6); 4.9844 (1.0); 4.2768 (2.4); 4.2596 (2.6); 4.2506 (3.0); 4.2336 (2.4); 4.0559 (1.2); 4.0381 (3.5); 4.0204 (3.5); 4.0025 (1.2); 3.8234 (1.8); 3.8151 (1.9); 3.7968 (1.6); 3.7893 (1.7); 3.3652 (0.6); 3.3083 (239.8); 3.2782 (1.0); 3.2631 (0.7); 3.2571 (1.0); 3.0835 (2.4); 3.0629 (2.7); 3.0401 (3.0); 3.0195 (2.7); 2.6738 (1.9); 2.6694 (2.7); 2.6649 (1.9); 2.6000 (2.2); 2.5920 (2.5); 2.5227 (16.1); 2.5179 (21.3); 2.5094 (159.3); 2.5049 (328.5); 2.5003 (452.2); 2.4957 (325.7); 2.4912 (153.7); 2.3939 (0.8); 2.3317 (2.2); 2.3271 (2.8); 2.3227 (2.2); 2.0723 (0.6); 1.9877 (16.0); 1.2459 (1.5); 1.1923 (4.3); 1.1745 (8.5); 1.1567 (4.2); 0.8752 (0.8); 0.8583 (2.2); 0.8406 (0.8); -0.0002 (13.6) I.3-2: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7226 (1.7); 8.7072 (1.6); 7.6936 (4.6); 7.6878 (1.6); 7.6813 (5.1); 7.6759 (2.5); 7.6704 (5.3); 7.6639 (1.8); 7.6581 (5.2); 7.4779 (5.2); 7.4715 (5.7); 7.4582 (5.4); 7.4368 (8.4); 7.3655 (4.6); 7.3590 (4.0); 7.3441 (2.9); 7.3376 (2.6); 7.2416 (5.2); 7.2357 (1.4); 7.2197 (7.1); 7.2026 (1.4); 7.1969 (4.6); 4.4172 (1.1); 4.1515 (2.3); 4.1346 (2.4); 4.1259 (2.9); 4.1093 (2.2); 3.6352 (2.2); 3.6275 (2.3); 3.6105 (16.0); 3.6023 (2.7); 3.3447 (0.6); 3.3128 (133.3); 3.3104 (175.4); 2.9460 (2.1); 2.9257 (2.4); 2.9032 (2.7); 2.8830 (2.4); 2.6741 (2.1); 2.6695 (2.8); 2.6648 (2.0); 2.5505 (0.9); 2.5230 (6.9); 2.5182 (10.4); 2.5096 (156.4); 2.5050 (344.5); 2.5004 (484.3); 2.4957 (340.7); 2.4912 (153.8); 2.4250 (2.3); 2.4160 (2.5); 2.3821 (2.0); 2.3734 (2.1); 2.3319 (2.1); 2.3272 (2.9); 2.3225 (2.1); 2.0726 (0.8); 0.0080 (1.8); -0.0002 (66.3); -0.0086 (1.8) I.3-3: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7233 (2.0); 8.7066 (1.9); 7.5361 (0.6); 7.5296 (0.7); 7.5031 (0.9); 7.4910 (4.1); 7.4853 (4.7); 7.4756 (6.5); 7.4691 (8.6); 7.4608 (9.6); 7.4541 (1.6); 7.4485 (1.0); 7.4396 (9.9); 7.4281 (0.6); 7.3900 (0.5); 7.3835 (0.5); 7.3667 (5.2); 7.3602 (4.6); 7.3453 (3.3); 7.3388 (3.0); 7.0378 (0.8); 7.0320 (1.3); 7.0264 (0.8); 7.0149 (1.7); 7.0091 (2.7); 7.0033 (1.3); 6.9914 (1.0); 6.9860 (1.4); 5.7539 (1.0); 4.4504 (0.5); 4.4424 (0.8); 4.4334 (1.2); 4.4231 (1.1); 4.4152 (1.2); 4.4065 (0.9); 4.3979 (0.6); 4.1424 (2.3); 4.1256 (2.5); 4.1162 (3.0); 4.0994 (2.3); 3.7247 (2.0); 3.6659 (2.3); 3.6587 (2.2); 3.6398 (2.1); 3.6326 (2.1); 3.6048 (16.0); 3.3125 (42.0); 3.0086 (2.4); 2.9883 (2.6); 2.9654 (3.0); 2.9452 (2.6); 2.6744 (0.9); 2.6698 (1.2); 2.6651 (0.9); 2.5232 (3.9); 2.5185 (5.7); 2.5098 (73.6); 2.5053 (158.5); 2.5006 (221.2); 2.4960 (154.1); 2.4914 (68.4); 2.4631 (2.7); 2.4546 (2.8); 2.4199 (2.1); 2.4115 (2.1); 2.3321 (1.0); 2.3275 (1.3); 2.3228 (0.9); -0.0002 (7.0) I.3-5: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7291 (2.1); 8.7132 (2.1); 7.8955 (4.5); 7.8897 (1.9); 7.8785 (3.0); 7.8726 (15.0); 7.8532 (14.5); 7.8473 (2.9); 7.8360 (1.7); 7.8303 (4.2); 7.4737 (5.8); 7.4673 (6.3); 7.4557 (5.9); 7.4343 (9.1); 7.3638 (4.7); 7.3572 (4.4); 7.3424 (3.1); 7.3358 (3.0); 5.7522 (5.5); 4.4386 (1.2); 4.1940 (2.3); 4.1771 (2.3); 4.1679 (2.8); 4.1514 (2.4); 4.0380 (0.5); 4.0205 (0.6); 3.7054 (2.2); 3.6980 (2.2); 3.6790 (2.0); 3.6720 (1.9); 3.6040 (16.0); 3.3057 (50.4); 3.0175 (2.3); 2.9972 (2.5); 2.9742 (2.9); 2.9542 (2.6); 2.6737 (1.4); 2.6692 (2.0); 2.6645 (1.3); 2.5226 (5.3); 2.5178 (7.7); 2.5092 (117.0); 2.5047 (250.0); 2.5001 (344.6); 2.4955 (241.8); 2.4910 (109.1); 2.4743 (2.9); 2.4399 (2.3); 2.4308 (2.0); 2.3317 (1.5); 2.3269 (2.0); 2.0101 (0.6); 1.9876 (2.3); 1.3457 (0.6); 1.3342 (0.8); 1.2392 (0.5); 1.1924 (0.6); 1.1746 (1.2); 1.1568 (0.6); 0.8882 (0.6); 0.8714 (0.7); 0.1460 (0.7); 0.0080 (5.0); -0.0002 (171.6); -0.0085 (5.3); -0.1494 (0.6) I.3-6: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7226 (1.5); 8.7061 (1.5); 7.5379 (6.0); 7.5331 (1.9); 7.5214 (2.1); 7.5166 (6.7); 7.4888 (0.5); 7.4788 (4.1); 7.4723 (4.6); 7.4581 (4.4); 7.4367 (6.8); 7.3657 (3.9); 7.3592 (3.4); 7.3443 (2.4); 7.3378 (2.2); 7.1893 (4.7); 7.1689 (4.2); 5.7549 (0.6); 4.4242 (0.7); 4.4154 (0.8); 4.4073 (0.8); 4.3958 (0.8); 4.3872 (0.7); 4.1268 (1.8); 4.1101 (2.0); 4.1012 (2.3); 4.0845 (1.7); 3.7234 (0.7); 3.6190 (2.2); 3.6105 (12.5); 3.5935 (1.6); 3.5861 (1.5); 3.3694 (1.4); 3.3543 (0.6); 3.3517 (0.8); 3.3197 (533.8); 3.2703 (4.1); 2.9331 (1.7); 2.9128 (2.0); 2.8904 (2.1); 2.8700 (1.9); 2.6746 (1.0); 2.6701 (1.5); 2.6654 (1.1); 2.5341 (0.6); 2.5236 (3.5); 2.5189 (5.0); 2.5102 (79.8); 2.5056 (177.0); 2.5010 (249.4); 2.4963 (173.3); 2.4917 (76.1); 2.4604 (1.1); 2.4559 (1.9); 2.4512 (2.6); 2.4466 (1.9); 2.4128 (1.9); 2.4037 (2.0); 2.3702 (1.6); 2.3611 (1.6); 2.3324 (1.2); 2.3278 (1.7); 2.3231 (1.1); 2.2790 (16.0); 2.0731 (1.4); -0.0002 (2.3) I.3-7: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7216 (0.9); 8.7053 (0.9); 7.5552 (3.4); 7.5496 (1.1); 7.5379 (1.2); 7.5324 (3.6); 7.4811 (2.1); 7.4747 (2.3); 7.4598 (2.0); 7.4384 (3.0); 7.3669 (1.6); 7.3605 (1.4); 7.3455 (1.0); 7.3390 (0.9); 6.9537 (3.7); 6.9481 (1.0); 6.9363 (1.1); 6.9309 (3.3); 4.1174 (0.9); 4.1006 (0.9); 4.0919 (1.1); 4.0752 (0.8); 3.7425 (16.0); 3.6139 (5.9); 3.6014 (1.0); 3.5936 (0.9); 3.5756 (0.8); 3.5682 (0.8); 3.3183 (33.3); 2.9147 (0.8); 2.8944 (0.9); 2.8722 (1.0); 2.8518 (0.9); 2.5234 (1.5); 2.5101 (14.9); 2.5056 (29.8); 2.5011 (39.8); 2.4966 (28.0); 2.4921 (13.0); 2.3980 (1.0); 2.3890 (0.9); 2.3555 (0.8); 2.3464 (0.8); 0.0080 (0.6); -0.0002 (15.0); -0.0084 (0.6) I.3-8: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7062 (2.0); 8.6897 (2.0); 7.7218 (0.9); 7.7137 (9.0); 7.7083 (2.7); 7.6966 (2.9); 7.6910 (10.8); 7.6830 (1.1); 7.4538 (1.2); 7.4458 (11.4); 7.4403 (3.0); 7.4286 (2.9); 7.4232 (9.6); 7.4174 (2.9); 7.4109 (1.5); 7.4058 (2.6); 7.4019 (2.2); 7.3943 (3.6); 7.3855 (0.5); 7.3652 (1.9); 7.3577 (1.6); 7.3540 (2.6); 7.3482 (1.6); 7.3420 (3.2); 7.2948 (1.2); 7.2905 (0.8); 7.2834 (6.7); 7.2823 (6.3); 7.2764 (3.9); 7.2720 (4.2); 7.2702 (4.4); 7.2659 (3.1); 7.2595 (5.1); 7.2475 (0.6); 4.4429 (0.8); 4.4338 (1.0); 4.4263 (1.0); 4.4230 (1.0); 4.4151 (1.0); 4.4064 (0.8); 4.1509 (2.2); 4.1340 (2.3); 4.1252 (2.7); 4.1085 (2.1); 3.6492 (2.0); 3.6416 (2.0); 3.6236 (1.9); 3.6161 (1.9); 3.5883 (16.0); 3.3209 (108.5); 3.2705 (1.0); 2.9626 (2.2); 2.9423 (2.3); 2.9197 (2.7); 2.8994 (2.4); 2.5237 (1.0); 2.5190 (1.5); 2.5102 (20.8); 2.5057 (45.7); 2.5011 (64.0); 2.4965 (45.0); 2.4919 (20.3); 2.4600 (0.5); 2.4554 (0.7); 2.4508 (1.0); 2.4458 (2.7); 2.4366 (2.3); 2.4028 (2.0); 2.3938 (2.0); -0.0002 (4.4) I.3-9: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7283 (2.2); 8.7122 (2.1); 7.7201 (1.1); 7.7120 (10.2); 7.7064 (3.1); 7.6948 (3.3); 7.6892 (12.3); 7.6812 (1.1); 7.4769 (5.7); 7.4706 (6.0); 7.4583 (6.3); 7.4537 (1.4); 7.4458 (13.0); 7.4401 (3.9); 7.4370 (9.7); 7.4285 (3.0); 7.4230 (10.5); 7.4150 (0.8); 7.3660 (5.2); 7.3595 (4.6); 7.3446 (3.3); 7.3381 (3.0); 4.4280 (1.0); 4.4199 (1.0); 4.4084 (1.0); 4.3998 (0.8); 4.1497 (2.3); 4.1329 (2.5); 4.1240 (2.9); 4.1073 (2.1); 3.6427 (2.2); 3.6354 (2.1); 3.6166 (2.6); 3.6078 (16.0); 3.3682 (0.8); 3.3510 (0.7); 3.3184 (408.3); 3.2683 (3.6); 2.9644 (2.4); 2.9441 (2.5); 2.9215 (2.9); 2.9012 (2.5); 2.6748 (1.0); 2.6700 (1.5); 2.6654 (1.0); 2.5236 (3.5); 2.5189 (5.0); 2.5102 (75.1); 2.5056 (166.7); 2.5010 (234.6); 2.4963 (162.9); 2.4917 (71.5); 2.4604 (1.1); 2.4556 (1.8); 2.4510 (2.4); 2.4464 (1.9); 2.4374 (2.7); 2.4285 (2.4); 2.3945 (2.1); 2.3856 (2.0); 2.3325 (1.1); 2.3278 (1.5); 2.3231 (1.0); 2.0735 (1.0); 1.9884 (2.1); 1.1923 (0.6); 1.1745 (1.4); 1.1566 (0.7); 0.0081 (1.5); 0.0041 (0.6); 0.0024 (1.6); -0.0002 (53.7); -0.0085 (1.6); -0.0502 (0.6) I.3-10: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.7826 (0.6); 7.7758 (0.7); 7.5032 (1.5); 7.4688 (5.6); 7.4626 (6.1); 7.4576 (6.3); 7.4363 (7.9); 7.4199 (0.6); 7.4054 (0.7); 7.3573 (4.5); 7.3507 (3.8); 7.3358 (3.1); 7.3293 (3.1); 7.3084 (0.7); 7.2734 (0.6); 7.2542 (2.0); 7.2361 (0.5); 7.0150 (1.6); 5.7538 (2.1); 4.5594 (1.1); 4.0380 (1.3); 4.0202 (1.2); 3.5680 (16.0); 3.3107 (324.8); 3.2608 (1.9); 3.1912 (0.6); 2.6741 (1.9); 2.6695 (2.7); 2.6648 (1.9); 2.5230 (6.7); 2.5183 (9.7); 2.5096 (147.3); 2.5050 (326.1); 2.5004 (460.0); 2.4957 (319.1); 2.4911 (140.6); 2.4595 (2.2); 2.4550 (3.2); 2.4504 (3.9); 2.4459 (2.7); 2.4007 (0.7); 2.3806 (1.0); 2.3319 (2.1); 2.3272 (2.9); 2.3225 (2.0); 2.0725 (0.8); 1.9878 (5.3); 1.2354 (1.0); 1.1923 (2.0); 1.1745 (3.6); 1.1567 (1.9); 0.1459 (0.8); 0.0080 (7.6); 0.0064 (1.2); 0.0055 (1.3); 0.0047 (1.7); 0.0038 (2.8); 0.0022 (9.2); -0.0002 (295.3); -0.0043 (6.6); -0.0052 (4.9); -0.0060 (4.1); -0.0068 (3.6); -0.0085 (9.4); -0.0107 (2.2); -0.0115 (1.9); - 0.0123 (1.7); -0.0132 (1.5); -0.0140 (1.4); -0.0148 (1.4); -0.0163 (1.2); -0.0171 (1.2); -0.0187 (1.0); - 0.0219 (0.9); -0.0322 (0.6); -0.0502 (1.9); -0.1200 (0.6); -0.1498 (0.9) I.3-11: 1H-NMR (400.0 MHz, d6-DMSO): δ= 16.1969 (1.7); 7.8949 (1.9); 7.5380 (4.4); 7.5344 (6.1); 7.5205 (5.2); 7.5186 (5.4); 7.5160 (6.7); 7.4871 (3.5); 7.4809 (3.5); 7.4700 (3.8); 7.4641 (5.0); 7.4570 (4.3); 7.4236 (3.7); 7.4097 (5.2); 7.4007 (5.0); 7.3854 (6.2); 7.3797 (6.5); 7.3668 (8.6); 7.3604 (7.8); 7.3577 (7.4); 7.3537 (5.1); 7.3483 (16.0); 7.3442 (9.3); 7.3397 (6.5); 7.3358 (8.7); 7.3305 (10.9); 7.3270 (11.5); 7.3225 (6.6); 7.3095 (6.0); 7.2986 (10.3); 7.2933 (10.4); 7.2896 (7.7); 7.2830 (9.2); 7.2756 (12.0); 7.2709 (5.4); 7.2627 (5.1); 7.2574 (9.6); 7.2528 (7.0); 7.2440 (5.8); 7.2401 (7.0); 7.2376 (6.5); 7.2344 (3.7); 7.2254 (4.7); 7.2200 (3.6); 7.2070 (1.8); 5.3133 (7.8); 4.1001 (3.0); 4.0566 (6.5); 4.0037 (6.4); 3.9598 (2.6); 3.7650 (13.2); 3.4143 (2.1); 3.4036 (4.3); 3.3954 (4.5); 3.3781 (4.9); 3.3669 (11.2); 3.3501 (3.2); 3.3459 (4.1); 3.3406 (17.1); 3.3128 (2813.9); 3.2941 (8.0); 3.2807 (4.9); 3.2783 (9.4); 3.2634 (15.8); 3.2220 (2.2); 3.2133 (2.5); 3.1936 (5.0); 2.6742 (8.2); 2.6695 (10.9); 2.6649 (7.7); 2.5231 (32.0); 2.5184 (45.3); 2.5097 (606.0); 2.5051 (1326.1); 2.5005 (1862.2); 2.4959 (1286.0); 2.4913 (559.9); 2.4656 (4.5); 2.4601 (6.9); 2.4552 (9.9); 2.4507 (11.9); 2.4461 (8.3); 2.4048 (2.8); 2.3320 (8.0); 2.3273 (11.8); 2.3226 (7.6); 2.0722 (2.2); 1.2361 (1.7); 1.1744 (5.2); 1.1566 (10.6); 1.1388 (4.7); 1.0458 (4.9); 1.0283 (10.2); 1.0106 (4.4); -0.0002 (37.3) I.3-12: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2219 (6.0); 8.7998 (3.0); 8.7831 (3.1); 7.9455 (2.4); 7.6726 (11.5); 7.6698 (14.3); 7.6506 (16.0); 7.6481 (13.5); 7.6242 (4.5); 7.6212 (5.2); 7.6021 (5.8); 7.5995 (5.1); 7.5333 (11.0); 7.5117 (13.1); 7.4156 (4.8); 7.4074 (11.7); 7.4023 (4.5); 7.3972 (6.3); 7.3942 (5.9); 7.3889 (15.5); 7.3754 (4.8); 7.3721 (4.2); 7.3672 (11.9); 7.2928 (3.9); 7.2777 (3.3); 7.1904 (2.3); 7.1679 (6.8); 7.1494 (10.1); 7.1309 (4.5); 4.9216 (1.9); 4.8666 (1.7); 4.2616 (4.6); 4.2454 (5.4); 4.2356 (6.1); 4.2269 (2.8); 4.2195 (5.0); 4.2118 (2.3); 4.2004 (2.7); 4.1851 (2.6); 4.0002 (1.8); 3.9717 (1.4); 3.7942 (3.6); 3.7751 (3.3); 3.3090 (478.0); 3.2581 (2.1); 3.1898 (1.4); 3.0822 (2.3); 3.0642 (4.8); 3.0455 (4.2); 3.0395 (3.4); 3.0219 (6.6); 3.0027 (4.3); 2.7615 (1.7); 2.7536 (1.5); 2.6740 (5.4); 2.6695 (7.6); 2.6648 (5.6); 2.5634 (2.7); 2.5228 (21.4); 2.5182 (29.7); 2.5095 (441.1); 2.5049 (976.2); 2.5003 (1372.0); 2.4957 (956.4); 2.4911 (431.7); 2.4542 (2.7); 2.4496 (3.8); 2.4453 (3.7); 2.3318 (6.1); 2.3271 (8.6); 2.3225 (6.2); 1.9878 (1.8); 0.0080 (5.9); -0.0002 (224.2); -0.0085 (6.7) I.3-15: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6226 (0.9); 8.6066 (0.9); 7.4931 (2.0); 7.4874 (2.2); 7.4676 (2.3); 7.4620 (1.8); 7.1686 (0.9); 7.1542 (1.8); 7.1479 (1.7); 7.1341 (1.4); 7.1289 (2.5); 7.1258 (2.4); 7.1180 (4.3); 7.1122 (3.2); 7.1025 (2.1); 7.0949 (1.9); 7.0879 (0.5); 7.0301 (0.7); 7.0125 (0.8); 7.0069 (1.3); 7.0012 (0.7); 6.9840 (0.7); 4.4297 (0.6); 4.4212 (0.6); 4.4113 (0.6); 4.4021 (0.5); 4.1361 (1.2); 4.1191 (1.3); 4.1100 (1.6); 4.0930 (1.2); 3.6489 (1.2); 3.6414 (1.1); 3.6232 (1.1); 3.6157 (1.0); 3.4362 (9.1); 3.3120 (63.5); 2.9956 (1.3); 2.9752 (1.3); 2.9525 (1.5); 2.9321 (1.4); 2.6741 (0.7); 2.6696 (1.0); 2.6649 (0.7); 2.5230 (3.2); 2.5182 (4.8); 2.5096 (58.8); 2.5051 (125.0); 2.5005 (172.4); 2.4959 (120.9); 2.4913 (53.9); 2.4567 (1.4); 2.4477 (1.3); 2.4135 (1.1); 2.4043 (1.1); 2.3319 (0.7); 2.3273 (1.0); 2.3226 (0.7); 2.2340 (16.0); -0.0002 (7.1) I.3-16: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5176 (1.2); 7.3267 (0.9); 7.3227 (1.0); 7.3077 (1.9); 7.3034 (2.5); 7.2886 (2.2); 7.2840 (2.4); 7.2755 (2.6); 7.2588 (208.4); 7.2418 (3.4); 7.2370 (5.9); 7.2185 (1.9); 7.2117 (1.3); 7.2034 (0.8); 7.1959 (0.8); 7.1821 (2.2); 7.1759 (1.5); 7.1721 (1.6); 7.1656 (1.0); 7.1566 (1.7); 7.1526 (2.2); 7.1475 (1.4); 7.1332 (0.8); 7.1273 (1.0); 7.1207 (1.4); 7.1172 (1.0); 7.1002 (0.9); 7.0967 (0.8); 6.9948 (1.2); 5.5897 (0.6); 4.6966 (0.5); 4.6896 (0.7); 4.6805 (0.8); 4.6713 (0.7); 4.1086 (1.2); 4.0911 (1.2); 4.0822 (1.4); 4.0653 (1.3); 3.6136 (10.6); 3.5852 (1.3); 3.5763 (1.3); 3.5590 (1.2); 3.5503 (1.1); 2.9212 (1.6); 2.9013 (1.8); 2.8777 (1.9); 2.8578 (1.9); 2.3252 (1.6); 2.3146 (1.6); 2.2846 (16.0); 2.2718 (1.4); 1.5295 (26.4); 1.2593 (0.7); 0.0079 (3.0); -0.0002 (84.0); -0.0085 (2.7) I.3-17: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5997 (1.4); 8.5826 (1.3); 7.8956 (3.2); 7.8899 (1.3); 7.8727 (9.8); 7.8497 (9.7); 7.8440 (1.9); 7.8325 (1.3); 7.8269 (3.0); 7.0134 (2.2); 6.9945 (3.3); 6.9509 (3.4); 6.9260 (2.2); 6.9067 (1.4); 5.7520 (3.1); 4.4371 (0.9); 4.1848 (1.6); 4.1680 (1.7); 4.1590 (1.9); 4.1425 (1.5); 3.6887 (1.5); 3.6811 (1.5); 3.6628 (1.3); 3.6555 (1.4); 3.3863 (11.0); 3.3036 (52.8); 3.0049 (1.6); 2.9847 (1.7); 2.9618 (1.9); 2.9416 (1.8); 2.6737 (1.3); 2.6688 (1.8); 2.6643 (1.3); 2.5224 (5.2); 2.5177 (7.4); 2.5090 (109.2); 2.5045 (231.4); 2.4999 (315.5); 2.4953 (220.4); 2.4908 (98.6); 2.4757 (2.4); 2.4667 (1.6); 2.4497 (0.6); 2.4328 (1.3); 2.4227 (1.4); 2.3313 (1.4); 2.3267 (1.9); 2.3224 (1.3); 2.1937 (15.6); 2.1699 (16.0); 0.1460 (0.6); 0.0080 (4.7); -0.0002 (153.6); -0.0085 (4.7); -0.1498 (0.7) I.3-20: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6993 (1.5); 8.6829 (1.4); 7.5397 (5.7); 7.5349 (1.8); 7.5233 (2.1); 7.5184 (6.6); 7.4174 (2.0); 7.4107 (1.1); 7.4056 (2.1); 7.4017 (1.7); 7.3942 (2.7); 7.3654 (1.4); 7.3577 (1.2); 7.3539 (2.0); 7.3480 (1.3); 7.3418 (2.5); 7.2943 (1.1); 7.2829 (5.4); 7.2816 (4.8); 7.2760 (3.1); 7.2714 (3.3); 7.2697 (3.4); 7.2654 (2.5); 7.2591 (3.8); 7.1897 (4.7); 7.1693 (4.2); 5.7550 (1.5); 4.4295 (0.7); 4.4211 (0.8); 4.4100 (0.8); 4.4023 (0.8); 4.1276 (1.8); 4.1108 (2.0); 4.1020 (2.3); 4.0853 (1.7); 3.6258 (1.7); 3.6179 (1.7); 3.5998 (1.9); 3.5901 (13.1); 3.3523 (0.6); 3.3197 (510.1); 3.2856 (0.9); 3.2701 (5.6); 2.9309 (1.7); 2.9105 (1.8); 2.8882 (2.2); 2.8678 (1.9); 2.6746 (1.0); 2.6700 (1.4); 2.6652 (1.0); 2.5235 (3.0); 2.5188 (4.4); 2.5101 (73.5); 2.5055 (163.0); 2.5009 (229.4); 2.4963 (160.8); 2.4917 (71.5); 2.4608 (1.7); 2.4560 (2.5); 2.4514 (3.0); 2.4469 (2.0); 2.4208 (1.9); 2.4115 (2.0); 2.3779 (1.6); 2.3687 (1.7); 2.3323 (1.1); 2.3276 (1.5); 2.3231 (1.0); 2.2797 (16.0); 2.0731 (1.0); 1.9882 (1.2); 1.1744 (0.7); -0.0002 (2.2) I.3-21: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5651 (2.4); 8.5488 (2.3); 7.4722 (6.8); 7.4661 (14.2); 7.4449 (11.1); 7.3701 (6.2); 7.3636 (5.4); 7.3488 (3.9); 7.3422 (3.6); 7.2551 (0.8); 7.2526 (0.7); 5.7541 (16.0); 4.5627 (0.6); 4.5107 (1.2); 4.4902 (2.3); 4.4701 (1.4); 4.4665 (1.3); 4.4466 (0.5); 4.3077 (0.6); 4.2990 (0.9); 4.2906 (1.2); 4.2812 (1.3); 4.2711 (1.2); 4.2629 (0.9); 4.2541 (0.6); 4.0384 (1.4); 4.0206 (1.4); 3.6977 (3.0); 3.6806 (3.2); 3.6723 (3.6); 3.6553 (3.0); 3.5947 (15.3); 3.3157 (59.2); 3.2474 (3.0); 3.2389 (3.0); 3.2220 (2.8); 3.2135 (2.7); 2.6485 (3.0); 2.6277 (3.4); 2.6063 (4.0); 2.5855 (3.5); 2.5238 (0.7); 2.5192 (1.1); 2.5105 (15.5); 2.5058 (34.1); 2.5012 (47.7); 2.4966 (33.2); 2.4920 (14.6); 2.1914 (0.5); 2.1803 (3.5); 2.1701 (4.9); 2.1422 (3.4); 2.1382 (5.3); 2.1278 (3.3); 2.1183 (2.5); 2.1142 (2.2); 2.0938 (0.8); 2.0895 (0.7); 2.0216 (0.6); 2.0188 (0.6); 2.0083 (1.3); 2.0063 (1.4); 1.9997 (1.6); 1.9962 (1.4); 1.9883 (8.8); 1.9809 (2.1); 1.9738 (1.9); 1.9706 (1.6); 1.9679 (1.7); 1.9626 (1.5); 1.9554 (1.6); 1.9368 (0.7); 1.6611 (0.8); 1.6521 (0.6); 1.6444 (2.4); 1.6362 (1.7); 1.6304 (2.1); 1.6198 (4.3); 1.6064 (2.5); 1.5952 (2.0); 1.5812 (0.8); 1.1927 (1.9); 1.1749 (4.0); 1.1571 (1.9); 0.0080 (1.0); -0.0002 (37.6); -0.0086 (1.0) I.3-22: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6320 (0.9); 8.6150 (0.9); 7.6627 (2.8); 7.6598 (3.4); 7.6548 (0.9); 7.6406 (3.9); 7.6381 (3.3); 7.3951 (2.7); 7.3898 (0.9); 7.3766 (3.6); 7.3736 (2.8); 7.3597 (1.0); 7.3549 (2.8); 7.1715 (1.0); 7.1575 (2.8); 7.1500 (1.7); 7.1394 (3.1); 7.1311 (1.5); 7.1258 (2.6); 7.1232 (2.9); 7.1149 (4.3); 7.1091 (3.4); 7.0994 (2.2); 7.0919 (2.0); 7.0853 (0.6); 4.4234 (0.6); 4.4155 (0.6); 4.4046 (0.6); 4.3957 (0.5); 4.1549 (1.5); 4.1380 (1.5); 4.1292 (1.8); 4.1125 (1.4); 3.6362 (1.2); 3.6284 (1.2); 3.6108 (1.2); 3.6029 (1.2); 3.4434 (9.1); 3.3116 (40.7); 2.9446 (1.4); 2.9243 (1.4); 2.9019 (1.7); 2.8816 (1.5); 2.6692 (0.7); 2.5227 (2.0); 2.5180 (2.8); 2.5094 (37.9); 2.5048 (81.5); 2.5002 (113.2); 2.4956 (79.1); 2.4910 (35.5); 2.4265 (1.3); 2.4174 (1.3); 2.3839 (1.2); 2.3745 (1.1); 2.3271 (0.6); 2.2346 (16.0); -0.0002 (16.3) I.3-23: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5308 (1.5); 8.5151 (1.5); 7.4204 (2.4); 7.4145 (1.4); 7.4077 (2.7); 7.4043 (2.2); 7.3973 (3.3); 7.3886 (0.5); 7.3544 (1.6); 7.3478 (1.5); 7.3444 (2.1); 7.3429 (1.5); 7.3372 (1.7); 7.3316 (3.1); 7.2981 (1.4); 7.2920 (0.6); 7.2863 (6.4); 7.2838 (5.4); 7.2798 (4.0); 7.2732 (6.2); 7.2671 (2.9); 7.2627 (3.5); 7.2607 (3.3); 7.2487 (0.6); 4.2971 (0.6); 4.2897 (0.9); 4.2800 (1.0); 4.2707 (0.9); 4.2640 (0.6); 3.6085 (2.6); 3.5912 (2.7); 3.5829 (3.3); 3.5704 (10.0); 3.3135 (202.8); 3.2638 (1.2); 3.1601 (2.4); 3.1511 (2.4); 3.1346 (2.2); 3.1257 (2.2); 3.0381 (1.0); 3.0189 (1.1); 3.0049 (2.6); 2.9860 (2.7); 2.9661 (2.4); 2.9478 (2.5); 2.9329 (1.0); 2.9147 (1.0); 2.6743 (0.6); 2.6697 (0.8); 2.6650 (0.6); 2.6498 (1.6); 2.6288 (1.7); 2.6076 (2.1); 2.5868 (1.9); 2.5231 (2.0); 2.5184 (2.8); 2.5097 (40.4); 2.5051 (89.6); 2.5005 (126.3); 2.4959 (87.2); 2.4913 (38.1); 2.4550 (0.6); 2.4505 (0.9); 2.4458 (0.6); 2.3319 (0.5); 2.3273 (0.8); 2.3226 (0.6); 2.2163 (2.1); 2.2057 (2.1); 2.1742 (1.8); 2.1636 (1.7); 1.8591 (0.6); 1.8412 (1.2); 1.8244 (1.6); 1.8076 (1.3); 1.7901 (0.6); 0.8324 (15.6); 0.8247 (16.0); 0.8158 (15.5); 0.8081 (15.2); -0.0002 (3.0) I.3-24: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5915 (1.3); 8.5754 (1.3); 7.5039 (0.6); 7.4922 (2.8); 7.4865 (3.2); 7.4667 (3.2); 7.4611 (2.6); 7.0346 (0.6); 7.0287 (1.0); 7.0175 (2.4); 7.0117 (1.4); 7.0057 (2.2); 6.9990 (4.0); 6.9887 (0.7); 6.9827 (1.1); 6.9771 (0.5); 6.9555 (3.3); 6.9293 (2.1); 6.9108 (1.3); 5.7537 (0.6); 4.4321 (0.6); 4.4235 (0.8); 4.4155 (0.8); 4.4044 (0.8); 4.3956 (0.7); 4.1318 (1.8); 4.1150 (1.8); 4.1057 (2.2); 4.0890 (1.7); 3.6498 (1.6); 3.6421 (1.6); 3.6236 (1.5); 3.6163 (1.4); 3.3868 (11.2); 3.3110 (50.7); 2.9957 (1.8); 2.9754 (1.9); 2.9525 (2.2); 2.9322 (1.9); 2.6741 (0.6); 2.6695 (0.8); 2.6649 (0.6); 2.5230 (2.6); 2.5183 (3.8); 2.5096 (46.4); 2.5050 (99.6); 2.5004 (137.5); 2.4958 (95.7); 2.4912 (42.4); 2.4565 (1.9); 2.4476 (1.8); 2.4134 (1.5); 2.4045 (1.5); 2.3318 (0.7); 2.3272 (0.8); 2.3226 (0.6); 2.2013 (15.5); 2.1761 (16.0); -0.0002 (6.2) I.3-25: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5923 (1.3); 8.5774 (1.3); 7.6929 (3.8); 7.6871 (1.3); 7.6806 (4.0); 7.6752 (2.0); 7.6697 (4.3); 7.6633 (1.3); 7.6574 (4.0); 7.2376 (4.2); 7.2318 (1.2); 7.2201 (1.4); 7.2156 (5.7); 7.2104 (1.3); 7.1987 (1.1); 7.1929 (3.7); 7.0151 (2.2); 6.9961 (3.3); 6.9578 (3.3); 6.9272 (2.0); 6.9085 (1.3); 5.7536 (1.0); 4.4229 (0.7); 4.4140 (0.8); 4.4056 (0.8); 4.3946 (0.8); 4.3864 (0.7); 4.1421 (1.9); 4.1254 (2.0); 4.1166 (2.4); 4.1000 (1.9); 3.6188 (1.7); 3.6112 (1.7); 3.5935 (1.5); 3.5858 (1.5); 3.3921 (11.3); 3.3102 (103.6); 3.0898 (0.6); 2.9339 (1.8); 2.9137 (2.0); 2.8911 (2.2); 2.8709 (2.0); 2.6740 (1.0); 2.6694 (1.4); 2.6647 (1.0); 2.5229 (3.7); 2.5182 (5.5); 2.5095 (80.6); 2.5049 (175.8); 2.5003 (246.2); 2.4957 (173.4); 2.4910 (77.6); 2.4183 (1.9); 2.4089 (1.9); 2.3756 (1.6); 2.3664 (1.5); 2.3317 (1.1); 2.3270 (1.5); 2.3225 (1.0); 2.2650 (0.5); 2.1986 (15.5); 2.1754 (16.0); 0.0080 (1.1); -0.0002 (36.0); -0.0085 (0.9) I.3-26: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6014 (1.3); 8.5859 (1.3); 7.6619 (4.0); 7.6591 (4.9); 7.6540 (1.3); 7.6399 (5.5); 7.6374 (4.6); 7.3945 (4.0); 7.3893 (1.2); 7.3760 (5.0); 7.3730 (3.9); 7.3590 (1.3); 7.3543 (3.9); 7.1595 (1.2); 7.1567 (2.0); 7.1541 (1.1); 7.1383 (3.3); 7.1226 (0.9); 7.1199 (1.4); 7.0144 (2.2); 6.9952 (3.4); 6.9593 (3.2); 6.9263 (2.1); 6.9070 (1.4); 5.7535 (1.2); 4.4255 (0.7); 4.4168 (0.8); 4.4093 (0.9); 4.3988 (0.9); 4.3899 (0.7); 4.1514 (2.0); 4.1347 (2.0); 4.1258 (2.5); 4.1091 (1.9); 3.6379 (1.7); 3.6302 (1.7); 3.6122 (1.6); 3.6048 (1.5); 3.3938 (11.4); 3.3112 (73.0); 3.3103 (66.3); 2.9440 (1.9); 2.9238 (2.0); 2.9013 (2.4); 2.8810 (2.1); 2.6739 (0.8); 2.6693 (1.1); 2.6646 (0.8); 2.5227 (3.2); 2.5180 (4.5); 2.5094 (61.1); 2.5048 (131.8); 2.5002 (183.1); 2.4956 (126.9); 2.4910 (56.1); 2.4269 (1.8); 2.4178 (1.7); 2.3844 (1.6); 2.3752 (1.6); 2.3316 (0.9); 2.3270 (1.0); 2.3223 (0.7); 2.1965 (15.6); 2.1762 (16.0); 0.0080 (0.5); -0.0002 (19.0); -0.0085 (0.6) I.3-27: 1H-NMR (400.0 MHz, CDCl3): δ= 7.4922 (2.9); 7.4865 (1.0); 7.4804 (3.0); 7.4748 (1.8); 7.4692 (3.2); 7.4631 (1.0); 7.4573 (3.2); 7.2599 (44.0); 7.2513 (0.6); 7.2423 (0.7); 7.2389 (1.6); 7.2277 (2.5); 7.2232 (3.6); 7.2187 (3.7); 7.2018 (1.9); 7.1957 (1.3); 7.1854 (0.7); 7.1798 (0.9); 7.1762 (0.6); 7.1714 (1.4); 7.1680 (2.2); 7.1551 (0.5); 7.1511 (0.8); 7.0636 (3.4); 7.0578 (1.0); 7.0462 (1.2); 7.0431 (3.8); 7.0407 (3.3); 7.0374 (1.1); 7.0258 (1.0); 7.0201 (2.9); 5.6218 (0.6); 5.6064 (0.6); 4.6364 (0.7); 4.6322 (0.5); 4.6271 (0.8); 4.6222 (0.5); 4.6177 (0.6); 4.1642 (1.9); 4.1472 (1.9); 4.1382 (2.2); 4.1213 (1.9); 3.6182 (1.7); 3.6083 (1.9); 3.5988 (11.0); 3.5925 (2.0); 3.5826 (1.5); 2.9540 (1.7); 2.9331 (1.7); 2.9104 (2.0); 2.8896 (1.9); 2.6082 (1.0); 2.3496 (1.6); 2.3376 (1.6); 2.3061 (1.4); 2.2941 (1.5); 2.2682 (16.0); 1.5644 (6.0); 0.0080 (0.5); -0.0002 (16.4); -0.0085 (0.5) I.3-28: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5180 (0.8); 7.3285 (1.0); 7.3245 (1.4); 7.3098 (2.2); 7.3052 (3.0); 7.2900 (2.2); 7.2856 (2.5); 7.2770 (1.7); 7.2705 (2.4); 7.2591 (129.0); 7.2504 (2.2); 7.2459 (1.3); 7.2378 (1.2); 7.2333 (0.9); 7.1764 (1.5); 7.1728 (1.9); 7.1575 (2.1); 7.1536 (3.1); 7.1485 (1.9); 7.1383 (1.0); 7.1343 (1.2); 7.1284 (1.5); 7.1216 (3.1); 7.1188 (3.0); 7.1011 (4.6); 7.0598 (2.2); 7.0401 (1.2); 6.9951 (1.0); 6.9859 (3.2); 5.6369 (0.9); 5.6196 (0.8); 4.6970 (0.7); 4.6897 (0.9); 4.6803 (1.0); 4.6720 (0.9); 4.6628 (0.7); 4.1062 (1.6); 4.0902 (1.6); 4.0799 (1.8); 4.0652 (1.6); 3.5918 (1.8); 3.5828 (1.9); 3.5671 (14.0); 3.5569 (1.8); 2.9204 (2.2); 2.9004 (2.3); 2.8769 (2.6); 2.8571 (2.4); 2.3305 (3.0); 2.3233 (15.8); 2.2873 (1.8); 2.2771 (1.8); 2.2274 (16.0); 1.5369 (8.9); 1.2586 (1.0); 0.0080 (1.9); -0.0002 (53.9); -0.0085 (1.8) I.3-29: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5421 (1.2); 8.5264 (1.2); 7.4666 (4.1); 7.4625 (5.5); 7.4603 (4.9); 7.4413 (6.5); 7.3672 (3.5); 7.3607 (3.0); 7.3458 (2.2); 7.3393 (2.0); 5.7527 (0.6); 4.2858 (0.5); 4.2785 (0.8); 4.2689 (0.8); 4.2587 (0.8); 4.2492 (0.5); 4.1922 (0.6); 4.1753 (1.5); 4.1583 (2.1); 4.1414 (1.5); 4.1244 (0.6); 3.5909 (9.5); 3.5557 (1.9); 3.5388 (2.0); 3.5304 (2.3); 3.5135 (2.0); 3.3055 (21.0); 3.0869 (1.9); 3.0782 (1.9); 3.0616 (1.7); 3.0529 (1.7); 2.6694 (0.6); 2.6249 (1.9); 2.6040 (2.1); 2.5828 (2.5); 2.5621 (2.2); 2.5228 (1.9); 2.5181 (2.7); 2.5094 (35.9); 2.5049 (77.7); 2.5002 (108.3); 2.4956 (75.4); 2.4911 (34.1); 2.3270 (0.6); 2.1750 (2.1); 2.1645 (2.0); 2.1330 (1.7); 2.1225 (1.7); 1.0628 (12.1); 1.0454 (16.0); 1.0268 (11.7); 0.0080 (1.8); -0.0002 (63.1); -0.0085 (1.9) I.3-30: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5935 (1.5); 8.5783 (1.5); 8.1378 (3.2); 8.1348 (3.4); 8.0274 (1.3); 8.0213 (1.3); 8.0121 (2.0); 8.0038 (1.5); 7.9980 (1.2); 7.6036 (6.2); 7.6016 (5.9); 7.5954 (2.8); 7.5919 (2.8); 7.5876 (3.4); 7.0164 (2.3); 6.9976 (3.4); 6.9563 (3.4); 6.9280 (2.2); 6.9093 (1.4); 5.7530 (5.6); 4.4386 (1.0); 4.1782 (1.6); 4.1615 (1.6); 4.1523 (2.0); 4.1356 (1.6); 3.6829 (1.6); 3.6750 (1.7); 3.6569 (1.5); 3.6495 (1.4); 3.4284 (0.9); 3.3904 (11.5); 3.3082 (241.4); 3.2579 (1.0); 2.9852 (1.6); 2.9651 (1.8); 2.9423 (2.0); 2.9221 (1.8); 2.6737 (2.4); 2.6693 (3.2); 2.6647 (2.5); 2.6202 (1.6); 2.5226 (18.7); 2.5179 (22.7); 2.5092 (177.7); 2.5047 (368.5); 2.5001 (509.9); 2.4956 (368.9); 2.4911 (175.8); 2.4637 (2.4); 2.4542 (2.9); 2.4491 (2.2); 2.4445 (2.4); 2.4208 (1.8); 2.4116 (1.8); 2.3316 (2.3); 2.3270 (3.0); 2.3223 (2.3); 2.1974 (15.8); 2.1765 (16.0); 1.9877 (0.7); 1.2415 (1.3); 0.8547 (0.7); -0.0002 (18.4) I.3-31: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7210 (0.9); 8.7046 (0.8); 7.5549 (3.3); 7.5493 (1.0); 7.5377 (1.2); 7.5321 (3.6); 7.4809 (2.0); 7.4744 (2.2); 7.4597 (1.9); 7.4383 (3.0); 7.3668 (1.6); 7.3603 (1.4); 7.3454 (1.0); 7.3389 (0.9); 6.9535 (3.6); 6.9479 (1.0); 6.9362 (1.0); 6.9307 (3.2); 4.1172 (0.8); 4.1004 (0.9); 4.0916 (1.0); 4.0750 (0.8); 3.7424 (16.0); 3.6137 (5.5); 3.6011 (1.0); 3.5933 (0.9); 3.5754 (0.8); 3.5679 (0.8); 3.3172 (54.3); 2.9145 (0.8); 2.8941 (0.8); 2.8719 (1.0); 2.8515 (0.9); 2.5472 (0.5); 2.5232 (1.8); 2.5100 (18.9); 2.5055 (38.1); 2.5010 (51.1); 2.4964 (35.8); 2.4919 (16.4); 2.4559 (0.6); 2.4514 (0.6); 2.3978 (0.9); 2.3887 (0.9); 2.3553 (0.8); 2.3462 (0.8); 1.9884 (0.5); 0.0080 (0.7); -0.0002 (19.4); -0.0086 (0.8) I.3-32: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4034 (1.2); 8.3877 (1.1); 7.0188 (2.2); 6.9998 (3.3); 6.9604 (3.3); 6.9321 (2.1); 6.9128 (1.3); 5.7520 (1.4); 4.2761 (0.6); 4.2688 (0.8); 4.2592 (1.0); 4.2493 (0.8); 4.2423 (0.6); 4.1875 (0.6); 4.1705 (1.6); 4.1536 (2.2); 4.1366 (1.6); 4.1196 (0.6); 3.5464 (2.0); 3.5295 (2.2); 3.5212 (2.4); 3.5043 (2.1); 3.4169 (0.7); 3.3798 (5.3); 3.3702 (5.4); 3.3332 (0.8); 3.3053 (27.6); 3.0572 (2.0); 3.0483 (2.0); 3.0320 (1.8); 3.0231 (1.8); 2.6117 (2.1); 2.5909 (2.2); 2.5698 (2.7); 2.5490 (2.3); 2.5223 (1.4); 2.5176 (1.9); 2.5090 (28.1); 2.5044 (62.0); 2.4998 (87.1); 2.4952 (61.0); 2.4906 (27.8); 2.4500 (0.5); 2.3265 (0.5); 2.2221 (15.4); 2.1819 (16.0); 2.1693 (2.5); 2.1585 (2.3); 2.1274 (1.8); 2.1166 (1.9); 1.0487 (12.9); 1.0393 (13.0); 1.0318 (13.3); 1.0224 (12.7); -0.0002 (13.2) I.3-33: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4331 (0.8); 8.4172 (0.8); 7.1643 (0.8); 7.1510 (1.8); 7.1424 (2.0); 7.1342 (1.3); 7.1283 (2.7); 7.1259 (2.4); 7.1180 (4.5); 7.1128 (3.3); 7.1036 (2.1); 7.0971 (1.2); 7.0947 (1.0); 7.0913 (0.6); 4.2730 (0.6); 4.2633 (0.7); 4.2534 (0.6); 4.1701 (1.1); 4.1531 (1.5); 4.1361 (1.1); 3.5496 (1.4); 3.5326 (1.5); 3.5244 (1.7); 3.5074 (1.5); 3.4270 (4.3); 3.4194 (4.4); 3.3065 (35.2); 3.0606 (1.4); 3.0515 (1.4); 3.0354 (1.3); 3.0264 (1.3); 2.6123 (1.4); 2.5914 (1.5); 2.5703 (1.9); 2.5495 (1.5); 2.5225 (1.1); 2.5178 (1.6); 2.5091 (23.8); 2.5045 (51.4); 2.4999 (71.8); 2.4953 (50.5); 2.4907 (22.9); 2.2377 (16.0); 2.1693 (1.6); 2.1583 (1.6); 2.1274 (1.3); 2.1164 (1.3); 1.0500 (9.0); 1.0396 (9.2); 1.0331 (9.4); 1.0227 (8.8) I.3-34: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.5210 (11.0); 7.4573 (15.5); 7.4291 (11.2); 7.4162 (9.6); 7.3973 (8.9); 5.3584 (9.7); 5.3277 (7.9); 4.0832 (10.1); 3.4321 (8.6); 3.3112 (4874.4); 3.2610 (55.6); 3.2210 (8.2); 2.6695 (32.5); 2.5094 (2043.6); 2.5050 (3959.1); 2.5005 (5216.0); 2.4959 (3820.1); 2.4915 (1932.9); 2.4552 (70.8); 2.4505 (77.9); 2.4458 (57.7); 2.4099 (21.6); 2.3272 (35.9); 1.0554 (7.3); 0.8201 (11.8); 0.8035 (16.0); 0.7754 (12.8); 0.6877 (11.8); 0.6713 (10.2); 0.0079 (36.9); -0.0002 (893.7); -0.0504 (14.4) I.3-35: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5374 (1.8); 8.5211 (1.8); 7.4252 (2.6); 7.4197 (1.6); 7.4145 (1.5); 7.4119 (2.4); 7.4088 (2.3); 7.4021 (3.6); 7.3932 (0.6); 7.3603 (1.8); 7.3535 (1.5); 7.3504 (2.1); 7.3478 (1.6); 7.3425 (1.9); 7.3371 (3.4); 7.3089 (0.5); 7.3027 (1.5); 7.2957 (0.6); 7.2905 (6.3); 7.2874 (5.6); 7.2843 (4.3); 7.2771 (8.5); 7.2703 (3.2); 7.2671 (3.6); 7.2641 (3.2); 7.2520 (0.7); 5.7538 (1.1); 4.5330 (0.7); 4.5144 (1.0); 4.4909 (1.9); 4.4708 (1.1); 4.4673 (1.0); 4.3030 (0.7); 4.2950 (1.0); 4.2855 (1.1); 4.2757 (1.0); 4.2678 (0.7); 4.0559 (1.0); 4.0381 (3.1); 4.0203 (3.1); 4.0025 (1.0); 3.6988 (2.4); 3.6816 (2.6); 3.6735 (3.0); 3.6563 (2.5); 3.6166 (0.8); 3.5780 (8.1); 3.5706 (8.2); 3.5320 (0.8); 3.3154 (55.5); 3.2555 (2.5); 3.2468 (2.5); 3.2301 (2.2); 3.2215 (2.2); 2.6448 (2.5); 2.6239 (2.8); 2.6025 (3.3); 2.5817 (2.9); 2.5231 (0.7); 2.5184 (1.0); 2.5097 (12.8); 2.5051 (28.0); 2.5005 (39.1); 2.4959 (27.1); 2.4913 (11.9); 2.1953 (0.6); 2.1880 (3.0); 2.1775 (3.1); 2.1705 (1.9); 2.1457 (5.1); 2.1354 (2.7); 2.1269 (1.0); 2.1195 (2.4); 2.0951 (0.8); 2.0193 (0.5); 2.0168 (0.5); 2.0063 (1.0); 2.0040 (1.1); 1.9990 (1.4); 1.9879 (16.0); 1.9837 (1.7); 1.9786 (1.7); 1.9727 (1.6); 1.9694 (1.4); 1.9662 (1.4); 1.9625 (1.2); 1.9586 (1.1); 1.9541 (1.2); 1.9463 (0.6); 1.9364 (0.6); 1.6607 (0.7); 1.6442 (2.0); 1.6358 (1.4); 1.6306 (1.8); 1.6198 (3.6); 1.6064 (2.0); 1.5952 (1.6); 1.5808 (0.6); 1.1922 (4.5); 1.1744 (8.9); 1.1566 (4.4); 0.0079 (0.8); -0.0002 (25.7); -0.0027 (1.1); -0.0085 (0.7) I.3-36: 1H-NMR (400.0 MHz, d6-DMSO): δ= 15.5677 (2.2); 15.5575 (1.9); 8.9875 (0.7); 8.9712 (0.6); 8.9426 (0.6); 8.9267 (0.6); 7.5529 (1.2); 7.5496 (1.4); 7.5343 (1.5); 7.5330 (1.6); 7.5306 (1.8); 7.4965 (0.8); 7.4905 (1.3); 7.4846 (1.3); 7.4802 (1.0); 7.4775 (0.8); 7.4738 (1.4); 7.4672 (1.1); 7.4565 (0.8); 7.4496 (0.6); 7.4446 (1.1); 7.4378 (1.5); 7.4320 (2.2); 7.4244 (1.4); 7.4217 (1.8); 7.4141 (2.0); 7.4085 (1.9); 7.3978 (0.8); 7.3946 (0.9); 7.3919 (0.9); 7.3890 (1.1); 7.3860 (0.8); 7.3832 (0.8); 7.3794 (0.7); 7.3772 (0.9); 7.3714 (1.2); 7.3645 (3.4); 7.3613 (2.7); 7.3589 (2.2); 7.3534 (2.6); 7.3512 (3.6); 7.3470 (3.0); 7.3411 (3.6); 7.3373 (3.2); 7.3316 (1.9); 7.3228 (0.9); 7.3180 (0.8); 7.3093 (1.9); 7.3030 (2.2); 7.3002 (2.5); 7.2941 (3.1); 7.2860 (4.4); 7.2797 (3.9); 7.2763 (2.6); 7.2697 (2.4); 7.2617 (1.0); 7.2572 (2.6); 7.2527 (2.1); 7.2464 (1.9); 7.2398 (2.3); 7.2341 (1.0); 7.2282 (1.4); 7.2224 (1.0); 7.2100 (0.5); 7.2043 (0.7); 7.1828 (0.6); 7.1743 (0.6); 7.1548 (0.5); 5.7541 (3.4); 5.2951 (2.9); 5.2706 (2.6); 4.4848 (0.6); 4.4563 (0.7); 4.4393 (0.6); 4.3554 (0.5); 4.3476 (0.5); 4.0915 (1.1); 4.0559 (1.2); 4.0480 (2.3); 4.0381 (3.4); 4.0203 (3.4); 4.0025 (1.1); 3.9833 (3.4); 3.9397 (1.6); 3.7665 (0.6); 3.7496 (0.6); 3.7408 (0.8); 3.7240 (0.6); 3.7167 (0.6); 3.7070 (0.6); 3.6966 (0.8); 3.6916 (1.0); 3.6810 (0.9); 3.6757 (0.7); 3.6651 (0.6); 3.3649 (1.2); 3.3584 (1.6); 3.3416 (2.4); 3.3324 (0.9); 3.3238 (1.2); 3.3133 (122.9); 3.2632 (1.0); 3.2494 (0.6); 3.2421 (0.5); 3.2162 (0.5); 3.1871 (0.6); 3.1728 (0.7); 3.1628 (0.6); 3.1575 (0.5); 3.1493 (0.7); 2.6974 (0.6); 2.6817 (0.7); 2.6769 (0.8); 2.6696 (0.7); 2.6649 (0.5); 2.6609 (0.9); 2.6550 (0.7); 2.6393 (0.8); 2.6346 (0.7); 2.6186 (0.7); 2.5231 (1.8); 2.5184 (2.8); 2.5097 (33.9); 2.5051 (74.6); 2.5005 (104.4); 2.4959 (73.1); 2.4913 (32.3); 2.4766 (1.0); 2.4710 (0.7); 2.4515 (1.6); 2.4456 (0.9); 2.4288 (0.7); 2.3273 (0.7); 2.3226 (0.5); 2.3153 (0.7); 2.2997 (0.7); 2.2855 (0.6); 2.2730 (0.5); 2.2688 (0.6); 2.1867 (1.2); 2.1777 (0.8); 2.1616 (1.3); 2.1443 (1.4); 2.1366 (1.8); 2.1131 (1.5); 2.1035 (1.0); 2.0921 (0.7); 2.0709 (1.0); 2.0613 (0.9); 1.9879 (16.0); 1.9685 (0.9); 1.9535 (1.0); 1.9379 (1.1); 1.9292 (0.9); 1.9106 (0.7); 1.6416 (0.6); 1.6257 (1.0); 1.6176 (1.5); 1.6090 (1.4); 1.6005 (1.6); 1.5947 (1.6); 1.5851 (1.4); 1.5609 (0.5); 1.2357 (0.6); 1.1922 (4.7); 1.1745 (9.6); 1.1567 (4.7); 0.0080 (2.0); 0.0063 (0.6); 0.0054 (0.6); 0.0046 (0.8); -0.0002 (70.4); -0.0052 (0.9); -0.0060 (0.7); -0.0068 (0.6); -0.0085 (2.0) I.3-37: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.5319 (6.8); 7.5109 (8.2); 7.4195 (8.0); 7.3799 (15.1); 7.3588 (16.0); 7.1665 (7.6); 7.1444 (5.5); 3.6619 (9.0); 3.3128 (232.5); 2.6695 (5.7); 2.5093 (399.5); 2.5048 (844.3); 2.5002 (1177.8); 2.4955 (845.7); 2.4910 (391.1); 2.4501 (5.9); 2.3270 (6.2); 0.0079 (12.6); -0.0002 (396.5); -0.0085 (14.3) I.4-11: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0560 (3.6); 8.0504 (3.6); 7.7346 (9.3); 7.7290 (2.3); 7.7174 (2.2); 7.7118 (8.1); 7.7037 (0.7); 7.4571 (0.8); 7.4491 (8.4); 7.4436 (2.2); 7.4319 (2.0); 7.4264 (7.1); 7.4183 (0.6); 7.3082 (1.8); 7.2917 (1.8); 7.1445 (2.4); 7.1430 (2.3); 7.1242 (2.7); 7.1227 (2.7); 6.9179 (2.4); 6.9121 (2.3); 6.8977 (2.0); 6.8920 (2.0); 4.4047 (0.5); 4.3974 (0.7); 4.3884 (0.8); 4.3795 (0.7); 4.3720 (0.6); 4.1695 (1.6); 4.1535 (1.6); 4.1440 (2.0); 4.1281 (1.5); 3.6956 (1.4); 3.6872 (1.3); 3.6701 (1.3); 3.6621 (1.2); 3.3655 (0.6); 3.3152 (123.1); 3.0031 (1.6); 2.9837 (1.7); 2.9606 (2.0); 2.9412 (1.7); 2.5236 (1.3); 2.5189 (1.8); 2.5102 (24.7); 2.5056 (53.8); 2.5010 (75.4); 2.4964 (52.3); 2.4918 (22.8); 2.4449 (1.6); 2.4348 (1.5); 2.4024 (1.4); 2.3924 (1.3); 2.1383 (16.0); 2.0728 (0.8); 0.0080 (1.2); -0.0002 (42.8); -0.0085 (1.2) I.4-12: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9179 (0.8); 8.5518 (4.1); 7.6652 (5.1); 7.6457 (6.3); 7.4692 (1.0); 7.4565 (1.1); 7.4462 (1.2); 7.4342 (1.1); 7.4105 (3.6); 7.3943 (6.0); 7.3887 (5.0); 7.3757 (9.6); 7.3545 (3.7); 7.1548 (2.0); 7.1364 (3.4); 7.1179 (1.9); 7.1095 (1.9); 7.0868 (1.3); 7.0779 (3.9); 7.0559 (6.9); 7.0337 (3.3); 6.8158 (2.2); 6.7993 (2.4); 4.3877 (1.3); 4.3789 (1.2); 4.1531 (2.0); 4.1362 (2.1); 4.1276 (2.4); 4.1111 (2.0); 3.6928 (2.0); 3.6833 (2.0); 3.6674 (1.9); 3.6579 (2.4); 3.3175 (18.7); 3.0806 (3.0); 3.0625 (3.0); 2.9439 (1.8); 2.9239 (2.0); 2.9014 (2.3); 2.8819 (2.1); 2.5059 (44.0); 2.5016 (56.3); 2.4977 (40.0); 2.4714 (3.0); 2.4599 (2.7); 2.4286 (1.9); 2.4174 (1.8); 2.0730 (1.6); 1.2056 (7.9); 1.1873 (16.0); 1.1692 (7.7); -0.0002 (2.4) I.4-21: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1638 (4.0); 8.1600 (3.9); 8.1430 (4.3); 8.1391 (4.0); 7.9748 (6.0); 7.7398 (1.5); 7.7317 (11.6); 7.7261 (3.4); 7.7144 (3.9); 7.7089 (13.3); 7.7010 (1.1); 7.6234 (2.9); 7.6075 (2.8); 7.4580 (1.7); 7.4500 (14.2); 7.4445 (3.8); 7.4328 (3.5); 7.4273 (11.5); 7.4192 (1.2); 7.4089 (4.2); 7.4053 (4.5); 7.3890 (4.8); 7.3852 (4.6); 7.2660 (2.1); 7.2622 (2.0); 7.2445 (3.3); 7.2266 (2.2); 7.2230 (2.0); 6.9840 (3.3); 6.9800 (3.0); 6.9655 (3.5); 6.9616 (3.3); 6.9456 (2.6); 6.9416 (2.3); 4.4015 (1.4); 4.3923 (1.5); 4.1720 (2.6); 4.1560 (2.8); 4.1465 (3.4); 4.1306 (2.5); 4.0559 (0.9); 4.0381 (2.4); 4.0204 (2.2); 4.0024 (0.8); 3.6926 (2.3); 3.6854 (2.3); 3.6677 (2.3); 3.6594 (2.2); 3.3751 (3.5); 3.3275 (386.4); 3.2762 (5.1); 3.2238 (0.6); 3.1127 (0.9); 3.1008 (1.0); 3.0944 (1.0); 3.0825 (1.0); 3.0040 (2.7); 2.9848 (3.0); 2.9615 (3.4); 2.9420 (3.0); 2.6745 (2.5); 2.6699 (3.4); 2.6652 (2.4); 2.5465 (3.6); 2.5234 (9.1); 2.5187 (13.2); 2.5100 (188.1); 2.5054 (411.0); 2.5008 (576.8); 2.4961 (404.4); 2.4915 (180.2); 2.4599 (2.7); 2.4553 (5.1); 2.4505 (7.5); 2.4460 (6.3); 2.4357 (3.9); 2.4259 (3.0); 2.3928 (2.8); 2.3832 (2.6); 2.3323 (2.6); 2.3275 (3.4); 2.3229 (2.5); 2.0725 (11.7); 1.9880 (10.9); 1.9081 (16.0); 1.1956 (1.8); 1.1923 (3.4); 1.1773 (4.0); 1.1746 (6.8); 1.1568 (3.4); 0.1463 (0.7); 0.0080 (6.5); 0.0056 (1.5); -0.0002 (237.8); -0.0085 (7.6); -0.0504 (2.2); -0.1496 (0.8) I.4-29: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1683 (2.5); 8.1645 (2.6); 8.1475 (2.8); 8.1436 (2.6); 7.9763 (3.8); 7.6271 (1.9); 7.6108 (1.9); 7.5661 (0.7); 7.5594 (5.8); 7.5546 (1.8); 7.5429 (1.9); 7.5380 (6.6); 7.5315 (0.6); 7.4074 (2.9); 7.4038 (2.9); 7.3874 (3.2); 7.3837 (3.0); 7.2646 (1.3); 7.2609 (1.2); 7.2460 (1.8); 7.2431 (2.2); 7.2254 (1.5); 7.2216 (1.4); 7.1965 (4.4); 7.1951 (4.8); 7.1747 (4.3); 7.1732 (3.7); 6.9813 (2.0); 6.9774 (2.1); 6.9629 (2.2); 6.9614 (2.2); 6.9590 (2.2); 6.9575 (2.2); 6.9430 (1.8); 6.9390 (1.6); 4.3940 (0.6); 4.3859 (0.8); 4.3777 (0.9); 4.3679 (0.8); 4.3603 (0.6); 4.1538 (1.9); 4.1379 (1.9); 4.1281 (2.3); 4.1124 (1.7); 3.6603 (1.6); 3.6524 (1.5); 3.6347 (1.5); 3.6268 (1.4); 3.3799 (0.8); 3.3311 (66.4); 3.2805 (1.2); 3.1108 (0.5); 3.0987 (0.5); 3.0925 (0.6); 3.0806 (0.6); 2.9767 (1.8); 2.9575 (1.9); 2.9344 (2.2); 2.9152 (1.9); 2.6746 (0.6); 2.6700 (0.8); 2.6653 (0.6); 2.5556 (0.8); 2.5513 (1.0); 2.5466 (0.8); 2.5235 (2.2); 2.5188 (3.1); 2.5101 (43.8); 2.5055 (96.0); 2.5009 (135.3); 2.4963 (93.9); 2.4917 (41.2); 2.4600 (0.8); 2.4556 (1.4); 2.4510 (1.8); 2.4464 (1.3); 2.4004 (1.9); 2.3908 (1.8); 2.3579 (1.5); 2.3484 (1.5); 2.3324 (0.7); 2.3277 (0.9); 2.3230 (0.7); 2.2801 (16.0); 1.9880 (0.6); 1.9084 (13.6); 1.1964 (1.0); 1.1782 (2.1); 1.1747 (0.6); 1.1600 (1.0); 0.0080 (0.7); -0.0002 (25.0); -0.0085 (0.7) I.4-30: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1120 (0.5); 8.1067 (0.5); 8.0643 (3.5); 8.0586 (3.4); 7.8610 (3.5); 7.7410 (0.6); 7.7200 (0.5); 7.7172 (0.6); 7.6915 (3.5); 7.6886 (4.4); 7.6835 (1.1); 7.6695 (4.8); 7.6669 (4.0); 7.4094 (0.7); 7.4008 (3.4); 7.3956 (1.1); 7.3877 (1.2); 7.3823 (4.4); 7.3794 (3.4); 7.3692 (0.7); 7.3654 (1.2); 7.3606 (3.4); 7.2282 (1.7); 7.2114 (1.6); 7.1599 (4.2); 7.1577 (3.2); 7.1415 (4.2); 7.1394 (4.2); 7.1259 (0.9); 7.1232 (1.5); 7.1205 (0.8); 6.9293 (2.3); 6.9235 (2.3); 6.9092 (2.0); 6.9033 (2.2); 4.1188 (1.1); 4.1005 (2.5); 4.0854 (1.5); 4.0784 (2.3); 4.0570 (1.1); 4.0396 (0.9); 3.6095 (1.2); 3.5947 (1.8); 3.5881 (1.7); 3.5727 (0.8); 3.3109 (107.6); 3.2608 (0.8); 2.6740 (0.7); 2.6695 (1.0); 2.6650 (0.8); 2.6230 (1.2); 2.6048 (1.6); 2.5852 (1.2); 2.5230 (2.4); 2.5184 (3.5); 2.5097 (54.9); 2.5051 (120.8); 2.5004 (168.9); 2.4958 (117.7); 2.4912 (52.0); 2.4596 (0.9); 2.4552 (1.4); 2.4505 (1.6); 2.4459 (1.1); 2.4412 (0.5); 2.3318 (0.8); 2.3272 (1.1); 2.3226 (0.8); 2.2544 (0.7); 2.1705 (16.0); 2.1289 (2.4); 1.2301 (11.3); 1.2122 (11.0); 1.1729 (0.8); 1.1195 (1.5); 1.1012 (1.5); 0.0081 (2.0); -0.0002 (75.4); -0.0086 (2.2); -0.0502 (0.6) I.4-39: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0631 (3.6); 8.0574 (3.6); 7.7333 (3.5); 7.5685 (0.7); 7.5619 (5.3); 7.5571 (1.6); 7.5455 (1.8); 7.5405 (6.0); 7.5340 (0.6); 7.3153 (1.7); 7.2989 (1.8); 7.1957 (4.0); 7.1942 (4.3); 7.1738 (3.9); 7.1722 (3.4); 7.1425 (2.4); 7.1409 (2.3); 7.1222 (2.7); 7.1207 (2.7); 6.9140 (2.4); 6.9084 (2.4); 6.8941 (2.0); 6.8883 (2.0); 4.3888 (0.5); 4.3813 (0.8); 4.3721 (0.8); 4.3633 (0.8); 4.3556 (0.6); 4.1511 (1.7); 4.1352 (1.7); 4.1255 (2.1); 4.1097 (1.6); 3.6624 (1.4); 3.6543 (1.4); 3.6369 (1.3); 3.6289 (1.2); 3.3411 (0.5); 3.3131 (184.7); 3.2805 (0.7); 3.2634 (1.5); 2.9757 (1.6); 2.9564 (1.8); 2.9334 (2.0); 2.9141 (1.8); 2.6743 (0.6); 2.6697 (0.8); 2.6650 (0.5); 2.5232 (2.4); 2.5185 (3.6); 2.5098 (43.9); 2.5052 (95.3); 2.5006 (133.6); 2.4959 (92.4); 2.4913 (40.4); 2.4690 (0.8); 2.4595 (0.7); 2.4553 (1.0); 2.4508 (1.2); 2.4460 (0.9); 2.4082 (1.5); 2.3986 (1.6); 2.3660 (1.3); 2.3562 (1.3); 2.3320 (0.6); 2.3274 (0.9); 2.3226 (0.6); 2.2797 (14.5); 2.2540 (0.6); 2.1379 (16.0); 2.0725 (0.5); 1.1764 (0.6); 0.0080 (2.2); -0.0002 (82.8); -0.0086 (2.4); -0.0500 (0.6) I.4-42: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4569 (1.8); 8.0140 (1.1); 8.0059 (1.1); 7.9978 (1.1); 7.9896 (1.1); 7.9857 (1.1); 7.9775 (1.0); 7.9694 (1.0); 7.9613 (0.9); 7.7290 (0.8); 7.7209 (7.3); 7.7154 (2.1); 7.7038 (2.4); 7.6982 (8.6); 7.6902 (0.7); 7.4555 (1.0); 7.4475 (9.0); 7.4419 (2.3); 7.4303 (2.2); 7.4248 (7.6); 7.4167 (0.6); 7.3144 (1.8); 7.2977 (1.8); 7.2589 (1.0); 7.2460 (1.2); 7.2363 (1.2); 7.2314 (1.1); 7.2233 (1.2); 7.2184 (1.2); 7.2088 (1.1); 7.1957 (1.1); 6.7789 (0.7); 6.7701 (1.1); 6.7616 (0.8); 6.7592 (0.9); 6.7564 (0.8); 6.7499 (1.3); 6.7417 (0.7); 6.7366 (0.6); 6.7279 (0.9); 4.4168 (0.6); 4.4091 (0.8); 4.4004 (0.9); 4.3914 (0.8); 4.3838 (0.6); 4.1648 (1.8); 4.1484 (1.9); 4.1393 (2.2); 4.1231 (1.7); 4.0560 (0.5); 4.0383 (1.6); 4.0205 (1.6); 4.0027 (0.6); 3.6915 (1.7); 3.6827 (1.7); 3.6662 (1.7); 3.6573 (1.7); 3.5502 (1.3); 2.9905 (1.8); 2.9711 (1.9); 2.9481 (2.2); 2.9285 (2.0); 2.6747 (0.6); 2.6700 (0.8); 2.6654 (0.6); 2.5235 (2.5); 2.5188 (3.7); 2.5101 (48.2); 2.5055 (104.2); 2.5009 (144.6); 2.4963 (100.0); 2.4917 (43.8); 2.4554 (0.6); 2.4508 (0.9); 2.4444 (2.0); 2.4336 (1.7); 2.4019 (1.5); 2.3913 (1.4); 2.3323 (0.7); 2.3276 (0.9); 2.3231 (0.7); 1.9881 (7.4); 1.9084 (16.0); 1.1984 (0.7); 1.1925 (2.2); 1.1802 (1.5); 1.1747 (4.4); 1.1621 (0.7); 1.1569 (2.1); 0.0080 (1.3); -0.0002 (46.8); -0.0086 (1.4) I.4-43: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4499 (1.7); 8.0179 (1.0); 8.0096 (1.0); 8.0016 (1.1); 7.9936 (1.0); 7.9893 (1.1); 7.9813 (1.0); 7.9731 (1.0); 7.9650 (1.0); 7.5471 (5.6); 7.5423 (1.6); 7.5307 (1.9); 7.5258 (6.4); 7.5191 (0.6); 7.3115 (1.7); 7.2949 (1.9); 7.2575 (1.0); 7.2445 (1.2); 7.2348 (1.2); 7.2300 (1.2); 7.2218 (1.2); 7.2170 (1.2); 7.2072 (1.2); 7.1940 (5.2); 7.1925 (4.9); 7.1720 (4.1); 7.1704 (3.6); 6.7761 (0.7); 6.7673 (1.0); 6.7564 (0.8); 6.7471 (1.3); 6.7389 (0.7); 6.7248 (0.9); 4.3928 (0.8); 4.3840 (0.9); 4.3756 (0.8); 4.1458 (1.8); 4.1297 (1.8); 4.1203 (2.3); 4.1040 (1.6); 3.6578 (1.5); 3.6492 (1.5); 3.6326 (1.5); 3.6242 (1.4); 3.3706 (26.6); 3.1089 (1.4); 3.0969 (1.4); 3.0906 (1.4); 3.0787 (1.4); 2.9634 (1.7); 2.9439 (1.9); 2.9211 (2.1); 2.9016 (1.9); 2.6744 (1.1); 2.6697 (1.6); 2.6651 (1.2); 2.5504 (0.7); 2.5457 (0.6); 2.5232 (4.0); 2.5185 (5.8); 2.5098 (87.0); 2.5052 (191.8); 2.5006 (268.7); 2.4960 (186.7); 2.4914 (81.8); 2.4597 (0.8); 2.4548 (1.2); 2.4503 (1.6); 2.4458 (1.4); 2.4073 (1.9); 2.3968 (1.8); 2.3649 (1.6); 2.3544 (1.5); 2.3367 (0.6); 2.3321 (1.3); 2.3274 (1.8); 2.3227 (1.3); 2.3180 (0.6); 2.2791 (15.3); 2.0725 (1.0); 1.9879 (1.1); 1.9081 (16.0); 1.1976 (2.6); 1.1794 (5.6); 1.1745 (0.9); 1.1611 (2.6); -0.0002 (16.0); -0.0085 (0.5) I.4-44: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2290 (3.8); 8.2230 (3.6); 8.1023 (1.9); 8.0982 (1.9); 8.0816 (3.4); 8.0774 (3.4); 8.0609 (1.9); 8.0568 (1.7); 7.9072 (6.2); 7.9016 (2.4); 7.8900 (3.9); 7.8843 (15.9); 7.8797 (2.7); 7.8619 (3.0); 7.8573 (16.0); 7.8515 (3.2); 7.8401 (2.3); 7.8345 (6.2); 7.7652 (0.9); 7.7428 (0.7); 7.2088 (3.2); 7.1988 (2.9); 7.1950 (3.8); 7.1785 (2.5); 7.1748 (2.5); 7.1698 (2.1); 7.1661 (2.2); 7.1492 (2.3); 7.1457 (2.5); 7.1038 (1.7); 7.0845 (3.3); 7.0648 (1.9); 6.9714 (1.5); 6.9672 (1.6); 6.9586 (1.5); 6.9542 (2.0); 6.9483 (1.7); 6.9399 (1.7); 6.9355 (1.7); 6.9281 (0.9); 6.9196 (0.9); 6.9155 (0.8); 5.7537 (4.6); 4.4263 (1.4); 4.4176 (1.5); 4.4092 (1.5); 4.4009 (1.1); 4.2050 (2.7); 4.1886 (2.9); 4.1793 (3.4); 4.1630 (2.6); 3.7511 (2.3); 3.7418 (2.4); 3.7256 (2.2); 3.7162 (2.1); 3.3647 (3.3); 3.3492 (2.3); 3.3150 (562.8); 3.2845 (1.6); 3.2648 (4.7); 3.2162 (0.5); 3.0336 (2.7); 3.0140 (3.0); 2.9908 (3.5); 2.9712 (3.0); 2.6746 (1.5); 2.6699 (2.1); 2.6654 (1.4); 2.5552 (1.7); 2.5508 (2.5); 2.5462 (2.4); 2.5348 (1.6); 2.5300 (1.1); 2.5235 (4.6); 2.5188 (7.1); 2.5101 (108.1); 2.5055 (236.0); 2.5009 (331.8); 2.4963 (231.6); 2.4917 (104.9); 2.4696 (2.0); 2.4566 (4.0); 2.4509 (4.1); 2.4468 (5.1); 2.3324 (1.4); 2.3277 (2.1); 2.3232 (1.5); 2.0727 (0.6); 1.1744 (1.0); 0.8584 (0.7); 0.0080 (1.7); -0.0002 (63.7); -0.0086 (2.0) I.4-45: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9073 (1.0); 7.9012 (1.1); 7.8840 (5.2); 7.8781 (6.1); 7.8736 (6.6); 7.8714 (5.6); 7.8505 (1.1); 7.8477 (0.7); 7.7149 (0.9); 7.7107 (1.3); 7.7039 (1.3); 7.6947 (1.1); 7.6907 (1.9); 7.6888 (1.1); 7.6852 (1.2); 7.5954 (0.8); 7.5907 (1.0); 7.5773 (1.9); 7.5722 (2.0); 7.5592 (1.6); 7.5525 (2.2); 7.5479 (0.8); 7.5409 (1.3); 7.5365 (1.5); 7.5330 (1.2); 7.5290 (1.4); 7.5224 (0.6); 7.5181 (0.6); 7.5147 (0.8); 7.5107 (0.7); 7.4980 (1.6); 7.4953 (1.6); 7.4914 (1.6); 7.4795 (1.0); 7.4763 (0.9); 5.7537 (16.0); 5.0869 (0.5); 5.0680 (0.8); 4.4238 (0.6); 4.4181 (0.6); 4.4038 (0.7); 4.3966 (1.1); 4.3903 (0.9); 4.3760 (0.6); 4.3693 (0.6); 4.1949 (0.6); 4.1894 (0.6); 4.1677 (0.5); 4.1614 (0.5); 4.0773 (0.6); 4.0717 (0.6); 4.0493 (0.6); 4.0436 (0.5); 3.3349 (25.3); 3.2438 (0.7); 3.2262 (0.6); 3.2191 (0.7); 3.1987 (0.9); 3.1812 (0.9); 3.1743 (0.7); 3.1569 (0.7); 3.0161 (0.8); 3.0094 (0.8); 2.9709 (0.6); 2.9641 (0.6); 2.9022 (0.7); 2.8956 (0.7); 2.8574 (0.6); 2.8507 (0.6); 2.6741 (1.1); 2.6695 (1.5); 2.6649 (1.1); 2.5229 (3.6); 2.5182 (5.4); 2.5096 (82.9); 2.5050 (183.7); 2.5003 (258.5); 2.4957 (178.9); 2.4911 (78.6); 2.4677 (1.0); 2.4553 (1.5); 2.4505 (1.8); 2.4459 (1.3); 2.3365 (0.5); 2.3317 (1.1); 2.3271 (1.5); 2.3225 (1.1); 2.0725 (0.5); 0.0080 (3.4); -0.0002 (129.6); -0.0085 (4.1); -0.0501 (2.0); -0.0641 (2.9) I.4-46: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3583 (2.8); 8.3522 (2.8); 8.2506 (1.7); 8.2440 (1.7); 8.1648 (0.9); 8.1607 (0.9); 8.1440 (1.7); 8.1399 (1.8); 8.1287 (1.5); 8.1241 (2.0); 8.1192 (1.1); 8.1080 (2.8); 8.1039 (2.8); 8.0872 (1.5); 8.0831 (1.4); 7.7290 (3.0); 7.7233 (1.2); 7.7157 (6.6); 7.7111 (2.6); 7.7057 (4.2); 7.7032 (5.6); 7.6977 (3.2); 7.6926 (6.9); 7.6857 (1.8); 7.6799 (5.1); 7.2526 (3.5); 7.2468 (1.2); 7.2409 (5.7); 7.2351 (2.6); 7.2307 (4.9); 7.2236 (2.2); 7.2190 (7.7); 7.2139 (3.6); 7.2114 (2.6); 7.2080 (3.8); 7.2020 (1.8); 7.1960 (6.5); 7.1913 (2.8); 7.1858 (1.9); 7.1821 (1.8); 7.1753 (1.3); 7.1716 (1.4); 7.1655 (2.6); 7.1620 (2.7); 7.1459 (1.3); 7.1424 (1.3); 7.1181 (1.8); 7.1086 (2.2); 7.1038 (3.0); 7.0979 (3.3); 7.0899 (4.4); 7.0733 (1.8); 7.0629 (1.1); 6.9800 (1.2); 6.9757 (1.3); 6.9672 (1.3); 6.9627 (1.6); 6.9552 (1.5); 6.9486 (1.6); 6.9441 (1.5); 6.9413 (1.8); 6.9367 (1.7); 6.9290 (1.2); 6.9228 (1.1); 6.9182 (0.9); 6.9108 (0.5); 5.7544 (13.2); 4.5110 (0.8); 4.4971 (0.8); 4.1218 (1.4); 4.1081 (1.7); 4.0959 (2.0); 4.0911 (1.5); 4.0820 (2.1); 4.0790 (2.6); 4.0719 (3.9); 4.0650 (1.8); 4.0599 (3.4); 4.0485 (1.1); 4.0415 (1.0); 4.0392 (1.0); 4.0212 (0.7); 3.6255 (1.6); 3.6206 (1.6); 3.6058 (0.9); 3.5996 (1.6); 3.5947 (1.7); 3.5800 (2.8); 3.5743 (2.8); 3.5484 (0.7); 3.3698 (0.6); 3.3199 (102.6); 3.2698 (1.2); 2.9679 (1.5); 2.9501 (2.1); 2.9323 (1.5); 2.6081 (1.5); 2.5899 (2.0); 2.5702 (1.5); 2.5528 (0.8); 2.5248 (0.9); 2.5202 (1.4); 2.5115 (20.4); 2.5069 (44.8); 2.5023 (62.8); 2.4977 (44.0); 2.4931 (19.7); 2.4567 (0.6); 2.4522 (0.8); 2.4476 (0.6); 1.9889 (3.0); 1.2466 (0.6); 1.2186 (16.0); 1.2007 (15.7); 1.1932 (1.6); 1.1753 (1.9); 1.1575 (0.9); 1.1092 (9.0); 1.0909 (8.9); 0.8581 (1.1); - 0.0002 (11.1) I.4-47: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.3011 (0.8); 8.3178 (7.6); 8.3114 (7.8); 8.2233 (1.6); 8.2171 (1.3); 8.1356 (5.6); 7.8979 (3.7); 7.8928 (7.0); 7.8875 (3.6); 7.7586 (2.5); 7.7422 (2.6); 7.5776 (2.2); 7.5567 (2.7); 7.5535 (2.7); 7.5321 (1.3); 7.5107 (1.4); 7.4517 (8.3); 7.4340 (4.2); 7.4302 (9.3); 7.4137 (6.4); 7.3932 (3.5); 7.2236 (2.7); 7.2214 (3.0); 7.2185 (2.7); 7.2013 (2.3); 7.1985 (2.5); 7.1561 (0.8); 7.1414 (0.8); 7.1348 (0.9); 7.0394 (5.5); 7.0330 (5.3); 7.0180 (4.7); 7.0115 (4.9); 5.2979 (3.1); 4.3844 (1.3); 4.1862 (2.4); 4.1701 (2.1); 4.1605 (2.6); 4.1447 (2.1); 3.7295 (1.9); 3.7203 (1.9); 3.7035 (2.0); 3.6955 (1.9); 3.4103 (0.9); 3.3915 (1.2); 3.3734 (3.4); 3.3609 (3.1); 3.3553 (4.0); 3.3460 (3.3); 3.3116 (1178.7); 3.2632 (1.3); 3.0939 (3.3); 3.0773 (3.0); 3.0265 (2.1); 3.0073 (2.3); 2.9838 (2.8); 2.9647 (2.3); 2.6743 (2.8); 2.6698 (3.9); 2.6651 (2.6); 2.5231 (11.9); 2.5184 (17.2); 2.5098 (231.5); 2.5052 (496.6); 2.5006 (688.5); 2.4960 (477.6); 2.4914 (212.7); 2.4522 (2.3); 2.4432 (2.3); 2.4098 (1.7); 2.4008 (2.0); 2.3320 (2.9); 2.3274 (3.8); 2.3227 (2.8); 1.2499 (2.4); 1.2319 (4.8); 1.2136 (2.4); 1.1965 (8.1); 1.1783 (16.0); 1.1601 (7.8); -0.0002 (3.2) I.4-48: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3213 (4.4); 8.3149 (4.2); 8.1320 (3.7); 7.7528 (1.8); 7.7361 (1.8); 7.5585 (4.9); 7.5371 (5.5); 7.5109 (0.6); 7.4494 (4.7); 7.4280 (5.0); 7.1955 (4.4); 7.1749 (4.0); 7.0358 (3.2); 7.0294 (3.0); 7.0144 (2.8); 7.0079 (2.7); 4.3756 (1.0); 4.1577 (1.6); 4.1422 (1.7); 4.1321 (2.0); 4.1163 (1.6); 3.6689 (1.6); 3.6610 (1.5); 3.6430 (1.4); 3.6347 (1.4); 3.5060 (1.0); 3.3641 (1.2); 3.3084 (380.4); 3.2744 (3.7); 3.2605 (3.6); 2.9854 (1.9); 2.9659 (1.8); 2.9427 (2.0); 2.9232 (1.9); 2.6739 (2.4); 2.6693 (3.1); 2.6648 (2.4); 2.5094 (170.5); 2.5049 (329.8); 2.5003 (436.0); 2.4957 (306.6); 2.4912 (145.4); 2.4027 (5.7); 2.3933 (5.3); 2.3601 (4.4); 2.3511 (4.2); 2.3318 (4.6); 2.3271 (5.2); 2.3224 (4.3); 2.2803 (16.0); 2.0720 (0.9); 1.2984 (0.7); 1.2585 (1.0); 1.2361 (1.6); 1.1722 (0.7); 0.0080 (1.5); -0.0002 (34.6); -0.0086 (1.4) I.4-49: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5807 (1.7); 7.5611 (2.3); 7.5184 (3.4); 7.4208 (2.1); 7.4121 (1.2); 7.4023 (2.6); 7.3917 (1.6); 7.3807 (1.8); 7.3241 (1.8); 7.3035 (1.4); 7.2931 (1.0); 7.2875 (1.3); 7.2828 (1.2); 7.2812 (1.2); 7.2804 (1.2); 7.2788 (1.3); 7.2772 (1.7); 7.2756 (2.1); 7.2748 (2.2); 7.2740 (2.4); 7.2732 (2.7); 7.2724 (3.1); 7.2716 (3.4); 7.2709 (3.6); 7.2700 (3.9); 7.2692 (4.3); 7.2685 (5.0); 7.2677 (5.5); 7.2669 (6.2); 7.2661 (7.3); 7.2652 (8.6); 7.2644 (10.9); 7.2636 (13.9); 7.2628 (19.1); 7.2595 (583.5); 7.2555 (7.5); 7.2547 (5.0); 7.2538 (3.8); 7.2530 (3.0); 7.2522 (2.4); 7.2514 (2.1); 7.2506 (1.5); 7.2498 (1.3); 7.2491 (1.0); 7.2482 (0.8); 7.2474 (0.8); 7.2458 (0.7); 7.2450 (0.6); 7.2275 (1.4); 7.2218 (2.3); 7.2164 (2.2); 7.2095 (6.7); 7.1902 (0.6); 6.9955 (3.4); 5.1885 (0.6); 4.2691 (1.1); 4.2483 (0.9); 4.2267 (0.8); 4.2116 (0.6); 4.2015 (0.8); 4.1863 (0.9); 3.2349 (0.6); 3.2174 (0.6); 3.1844 (0.6); 3.1667 (0.6); 3.1063 (0.7); 3.0990 (0.7); 3.0832 (0.7); 3.0752 (0.7); 3.0322 (0.5); 2.1890 (10.0); 2.0439 (1.2); 1.5361 (16.0); 1.2588 (1.2); 0.8819 (1.7); 0.8639 (0.7); 0.1460 (0.6); 0.0112 (1.3); 0.0104 (1.5); 0.0080 (8.1); 0.0064 (3.1); 0.0056 (3.3); 0.0048 (4.2); 0.0039 (5.1); -0.0002 (244.4); -0.0042 (5.1); -0.0050 (3.3); -0.0059 (2.7); -0.0067 (2.3); - 0.0084 (6.9); -0.0146 (0.6); -0.0501 (2.3); -0.1494 (0.7) I.4-50: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.0282 (1.6); 9.0245 (1.7); 9.0172 (1.7); 8.6478 (0.9); 8.6273 (0.9); 8.0848 (1.6); 8.0626 (5.2); 8.0570 (3.9); 7.9759 (3.3); 7.8752 (1.4); 7.8577 (1.8); 7.7680 (1.6); 7.7480 (2.6); 7.7292 (1.7); 7.7128 (0.9); 7.6308 (0.8); 7.6143 (0.8); 7.1592 (2.4); 7.1389 (2.8); 6.9222 (2.2); 6.9166 (2.2); 6.9020 (1.9); 6.8964 (1.9); 5.7546 (0.6); 4.5690 (0.8); 4.3533 (1.6); 4.3365 (1.7); 4.3290 (2.0); 4.3122 (1.6); 3.8559 (2.9); 3.8449 (3.1); 3.8316 (3.4); 3.8206 (3.7); 3.7582 (4.9); 3.0082 (1.4); 2.9882 (1.6); 2.9660 (1.8); 2.9462 (1.6); 2.6710 (0.6); 2.5242 (2.0); 2.5109 (37.9); 2.5064 (80.4); 2.5018 (111.1); 2.4972 (82.2); 2.4927 (39.8); 2.4558 (2.3); 2.4473 (1.3); 2.4425 (1.9); 2.3334 (0.5); 2.3285 (0.7); 2.3239 (0.5); 2.1988 (16.0); 1.9092 (3.2); 1.2078 (0.6); 1.1897 (1.3); 1.1714 (0.6); -0.0002 (1.0) I.4-51: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1600 (1.6); 8.1578 (2.8); 8.1547 (2.9); 8.1527 (2.3); 8.1512 (2.3); 8.0530 (4.5); 8.0474 (4.3); 8.0432 (1.4); 8.0381 (1.4); 8.0363 (1.4); 8.0335 (1.1); 8.0288 (1.4); 8.0229 (1.3); 7.7626 (3.6); 7.6171 (0.5); 7.6105 (6.0); 7.6084 (5.0); 7.6014 (2.7); 7.5980 (3.0); 7.5960 (3.3); 7.5945 (3.0); 7.3303 (1.7); 7.3141 (1.7); 7.1467 (2.3); 7.1453 (2.3); 7.1264 (2.7); 7.1250 (2.7); 6.9209 (2.3); 6.9152 (2.3); 6.9008 (2.0); 6.8950 (1.9); 4.4267 (0.5); 4.4190 (0.7); 4.4100 (0.8); 4.4008 (0.7); 4.3937 (0.6); 4.2053 (1.5); 4.1891 (1.5); 4.1796 (1.9); 4.1636 (1.4); 3.7622 (1.4); 3.7534 (1.3); 3.7365 (1.2); 3.7280 (1.2); 3.3638 (65.6); 3.3134 (1.1); 3.0354 (1.5); 3.0159 (1.6); 2.9927 (1.9); 2.9731 (1.7); 2.6704 (0.6); 2.5239 (1.2); 2.5192 (1.8); 2.5105 (31.4); 2.5059 (69.2); 2.5013 (97.4); 2.4967 (67.9); 2.4921 (30.0); 2.4754 (1.7); 2.4555 (0.8); 2.4509 (1.2); 2.4428 (1.7); 2.4326 (1.4); 2.3281 (0.6); 2.1423 (16.0); 2.0729 (1.7); 1.1795 (0.7); 0.0080 (1.0); -0.0002 (34.5); -0.0086 (1.0) I.4-52: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0481 (3.5); 8.0424 (3.5); 7.9171 (3.8); 7.9117 (1.6); 7.8999 (2.0); 7.8942 (8.7); 7.8894 (1.5); 7.8655 (1.5); 7.8606 (8.7); 7.8549 (1.8); 7.8432 (1.4); 7.8378 (3.8); 7.7401 (3.6); 7.3094 (1.8); 7.2930 (1.7); 7.1448 (2.4); 7.1434 (2.3); 7.1246 (2.8); 7.1231 (2.8); 6.9202 (2.3); 6.9146 (2.3); 6.9002 (1.9); 6.8945 (1.9); 4.4279 (0.5); 4.4197 (0.7); 4.4113 (0.9); 4.4034 (0.8); 4.3948 (0.6); 4.2122 (1.5); 4.1960 (1.5); 4.1865 (1.9); 4.1704 (1.4); 3.7614 (1.3); 3.7531 (1.3); 3.7357 (1.2); 3.7272 (1.1); 3.3114 (70.1); 3.0520 (1.4); 3.0325 (1.6); 3.0092 (1.8); 2.9897 (1.6); 2.6698 (0.6); 2.5234 (1.4); 2.5186 (2.2); 2.5100 (34.3); 2.5054 (75.7); 2.5008 (106.7); 2.4961 (74.4); 2.4915 (34.3); 2.4593 (1.6); 2.4497 (1.8); 2.3275 (0.6); 2.1362 (16.0); 2.0728 (1.2); 0.0080 (1.4); 0.0048 (0.5); -0.0002 (48.5); -0.0085 (1.4) I.4-53: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.0202 (1.2); 9.0163 (1.3); 9.0094 (1.2); 9.0055 (1.2); 8.6258 (0.7); 8.6071 (0.6); 8.3850 (1.6); 8.3792 (1.5); 8.1303 (0.8); 8.1262 (0.9); 8.1095 (1.6); 8.1054 (1.6); 8.0888 (1.0); 8.0846 (0.9); 8.0729 (1.2); 8.0545 (1.3); 7.8544 (1.0); 7.8380 (1.4); 7.7594 (1.3); 7.7396 (1.7); 7.7297 (0.8); 7.7200 (1.4); 7.7087 (0.7); 7.6980 (0.6); 7.3997 (0.8); 7.3839 (0.7); 7.2175 (1.0); 7.2139 (1.0); 7.1970 (1.1); 7.1934 (1.1); 7.1881 (0.9); 7.1846 (1.0); 7.1678 (1.1); 7.1642 (1.2); 7.1105 (0.8); 7.0915 (1.4); 7.0718 (0.8); 6.9765 (0.7); 6.9723 (0.7); 6.9638 (0.8); 6.9594 (0.9); 6.9537 (0.7); 6.9451 (0.8); 6.9407 (0.8); 5.7549 (16.0); 4.5910 (0.6); 4.5751 (0.6); 4.3492 (1.4); 4.3323 (1.4); 4.3248 (1.8); 4.3079 (1.3); 3.8451 (3.9); 3.8339 (4.2); 3.8207 (4.3); 3.8098 (4.1); 3.1073 (0.8); 3.0952 (0.8); 3.0890 (2.6); 3.0769 (2.6); 3.0707 (2.6); 3.0587 (2.6); 3.0526 (0.9); 3.0405 (0.8); 2.9979 (1.3); 2.9780 (1.4); 2.9559 (1.6); 2.9361 (1.4); 2.6708 (0.7); 2.5518 (0.7); 2.5243 (1.6); 2.5196 (2.5); 2.5110 (37.4); 2.5064 (82.4); 2.5017 (116.7); 2.4971 (81.8); 2.4925 (36.4); 2.4708 (1.8); 2.4610 (0.6); 2.4562 (1.0); 2.4517 (1.2); 2.4472 (1.1); 2.4422 (1.5); 2.4288 (1.1); 2.3285 (0.7); 2.3239 (0.5); 2.0734 (9.7); 1.2073 (5.0); 1.1891 (10.8); 1.1708 (5.0); 0.0081 (1.8); 0.0049 (0.5); -0.0002 (68.8); -0.0086 (2.0) I.4-54: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9897 (1.1); 8.9856 (1.2); 8.9791 (1.2); 8.9749 (1.1); 8.5619 (0.6); 8.5423 (0.6); 8.1743 (1.6); 8.1705 (1.6); 8.1535 (1.7); 8.1497 (1.6); 8.0996 (2.4); 8.0434 (1.0); 8.0264 (1.1); 7.8288 (1.0); 7.8106 (1.3); 7.7618 (0.9); 7.7443 (0.9); 7.7331 (1.3); 7.7130 (1.6); 7.6941 (0.9); 7.6866 (0.8); 7.6757 (0.7); 7.6657 (0.7); 7.6547 (0.7); 7.4276 (1.8); 7.4240 (1.8); 7.4075 (1.9); 7.4039 (1.9); 7.2715 (0.8); 7.2679 (0.8); 7.2529 (1.1); 7.2501 (1.3); 7.2323 (0.9); 7.2286 (0.9); 7.1928 (0.8); 7.1891 (0.9); 7.1730 (0.9); 7.1692 (0.9); 7.0446 (0.5); 7.0246 (0.7); 7.0208 (0.6); 7.0064 (0.7); 7.0027 (0.6); 6.9924 (1.2); 6.9884 (1.3); 6.9739 (1.4); 6.9724 (1.4); 6.9700 (1.3); 6.9684 (1.4); 6.9540 (1.1); 6.9500 (1.1); 6.8197 (0.8); 6.8158 (0.8); 6.7998 (0.6); 6.7956 (0.7); 6.5557 (0.6); 4.5556 (0.5); 4.3635 (1.2); 4.3468 (1.2); 4.3390 (1.5); 4.3223 (1.1); 4.0560 (0.8); 4.0381 (2.4); 4.0203 (2.4); 4.0025 (0.9); 3.8530 (1.5); 3.8424 (1.5); 3.8286 (1.6); 3.8177 (1.6); 3.6332 (6.3); 3.0977 (0.9); 3.0857 (0.9); 3.0795 (0.9); 3.0675 (0.8); 3.0101 (1.1); 2.9903 (1.2); 2.9682 (1.4); 2.9483 (1.2); 2.6748 (1.0); 2.6702 (1.5); 2.6654 (1.0); 2.5513 (1.6); 2.5468 (1.4); 2.5236 (3.9); 2.5189 (5.6); 2.5103 (80.4); 2.5056 (176.6); 2.5010 (248.4); 2.4964 (172.6); 2.4918 (76.0); 2.4722 (1.9); 2.4597 (2.3); 2.4557 (2.6); 2.4510 (3.4); 2.4464 (2.6); 2.4416 (1.4); 2.4303 (1.2); 2.4171 (1.0); 2.4008 (0.6); 2.3324 (1.2); 2.3278 (1.6); 2.3232 (1.1); 2.0728 (1.4); 1.9880 (10.9); 1.9084 (16.0); 1.2028 (1.6); 1.1923 (3.2); 1.1846 (3.4); 1.1745 (6.7); 1.1663 (1.7); 1.1567 (3.2); 0.0080 (3.4); 0.0063 (0.8); 0.0055 (0.8); 0.0046 (1.0); 0.0038 (1.4); -0.0002 (127.5); -0.0027 (5.9); -0.0043 (2.5); - 0.0052 (1.8); -0.0060 (1.5); -0.0068 (1.3); -0.0085 (3.9); -0.0502 (1.2) I.4-55: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.0260 (2.1); 8.1623 (10.4); 8.1585 (10.7); 8.1415 (11.6); 8.1377 (10.9); 8.0802 (1.7); 8.0760 (1.6); 8.0591 (1.6); 8.0554 (1.7); 7.9792 (16.0); 7.6227 (7.6); 7.6061 (7.6); 7.5301 (1.4); 7.5229 (2.3); 7.5115 (11.7); 7.5057 (13.1); 7.4859 (13.6); 7.4803 (11.6); 7.4687 (1.9); 7.4617 (2.8); 7.4580 (2.1); 7.4113 (11.7); 7.4077 (12.4); 7.3913 (12.7); 7.3876 (12.8); 7.3271 (0.8); 7.3050 (1.3); 7.2881 (0.9); 7.2690 (5.2); 7.2653 (5.1); 7.2503 (7.1); 7.2474 (8.7); 7.2298 (5.8); 7.2260 (5.4); 7.1767 (0.7); 7.1733 (0.8); 7.1570 (0.8); 7.1536 (0.7); 7.0849 (1.3); 7.0809 (1.3); 7.0609 (1.5); 7.0463 (1.2); 7.0419 (3.2); 7.0358 (4.6); 7.0298 (2.6); 7.0184 (5.5); 7.0126 (9.3); 7.0069 (4.8); 6.9953 (3.1); 6.9875 (10.2); 6.9835 (11.0); 6.9689 (9.2); 6.9674 (8.8); 6.9650 (9.0); 6.9635 (8.9); 6.9490 (7.3); 6.9450 (6.9); 6.7932 (0.8); 6.7895 (0.8); 6.7692 (0.8); 6.5454 (0.6); 6.5257 (0.6); 5.7538 (1.6); 4.4262 (1.4); 4.4172 (2.4); 4.4102 (3.3); 4.4012 (3.7); 4.3921 (3.5); 4.3841 (2.6); 4.3747 (1.6); 4.3662 (0.9); 4.1614 (7.0); 4.1452 (7.3); 4.1354 (8.8); 4.1194 (6.7); 3.7257 (6.2); 3.7173 (6.0); 3.6998 (5.7); 3.6915 (5.5); 3.3963 (3.1); 3.3480 (256.4); 3.2975 (4.3); 3.1280 (0.9); 3.1159 (0.9); 3.1098 (2.6); 3.0978 (2.4); 3.0916 (2.6); 3.0795 (2.5); 3.0613 (0.9); 3.0443 (7.2); 3.0247 (7.9); 3.0014 (9.1); 2.9820 (8.0); 2.6749 (2.2); 2.6702 (3.3); 2.6657 (2.2); 2.5513 (3.2); 2.5237 (7.1); 2.5190 (10.2); 2.5104 (165.9); 2.5058 (365.7); 2.5011 (514.8); 2.4965 (359.2); 2.4919 (158.6); 2.4769 (9.0); 2.4671 (8.5); 2.4558 (5.2); 2.4512 (6.5); 2.4468 (4.9); 2.4341 (6.7); 2.4241 (6.5); 2.3326 (2.5); 2.3280 (3.2); 2.3233 (2.3); 2.0729 (0.7); 1.9881 (0.9); 1.9086 (0.8); 1.1975 (4.9); 1.1794 (10.4); 1.1612 (4.9); 0.8583 (0.7); 0.8339 (0.5); 0.0080 (2.7); -0.0002 (91.5); -0.0085 (2.6); -0.0501 (0.6) I.4-56: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9698 (2.1); 8.9657 (2.3); 8.9594 (2.2); 8.9550 (2.1); 8.5855 (1.8); 8.5146 (1.2); 8.4958 (1.3); 8.0356 (1.0); 8.0255 (2.2); 8.0214 (2.3); 8.0113 (1.2); 8.0048 (2.4); 8.0012 (2.3); 7.9909 (1.0); 7.9828 (0.9); 7.7965 (1.6); 7.7932 (1.7); 7.7782 (2.5); 7.7748 (2.3); 7.7108 (2.4); 7.6911 (2.8); 7.6720 (1.6); 7.6553 (1.6); 7.6447 (1.5); 7.6344 (1.5); 7.6235 (1.4); 7.4327 (1.7); 7.4154 (1.6); 7.2782 (1.0); 7.2652 (1.1); 7.2556 (1.1); 7.2507 (1.1); 7.2424 (1.1); 7.2377 (1.0); 7.2281 (1.1); 7.2149 (1.0); 6.7850 (0.7); 6.7763 (0.9); 6.7652 (0.9); 6.7558 (1.2); 6.7479 (0.7); 6.7336 (0.9); 4.5550 (0.9); 4.3655 (1.8); 4.3488 (1.8); 4.3408 (2.4); 4.3242 (1.7); 4.0561 (0.7); 4.0381 (2.0); 4.0204 (2.0); 4.0026 (0.8); 3.8438 (2.2); 3.8328 (2.4); 3.8187 (2.4); 3.8082 (2.5); 3.7188 (2.9); 3.1033 (0.8); 3.0913 (0.7); 3.0852 (0.7); 3.0731 (0.8); 3.0016 (1.7); 2.9818 (1.8); 2.9595 (2.1); 2.9397 (1.9); 2.6744 (1.4); 2.6697 (1.9); 2.6651 (1.4); 2.5233 (4.7); 2.5186 (7.0); 2.5099 (109.9); 2.5053 (240.8); 2.5007 (337.6); 2.4961 (235.8); 2.4915 (104.4); 2.4651 (2.5); 2.4512 (3.2); 2.4460 (1.9); 2.4228 (1.7); 2.4105 (2.0); 2.3322 (1.6); 2.3274 (2.1); 2.3230 (1.5); 1.9879 (8.7); 1.9083 (16.0); 1.2000 (1.4); 1.1923 (2.5); 1.1819 (3.0); 1.1746 (5.2); 1.1638 (1.4); 1.1568 (2.5); 0.0080 (2.6); -0.0002 (100.8); -0.0085 (3.0); -0.0501 (0.6) I.4-57: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4557 (3.2); 8.0108 (1.9); 8.0028 (1.9); 7.9946 (1.8); 7.9865 (1.9); 7.9827 (2.0); 7.9745 (1.8); 7.9663 (1.8); 7.9582 (1.7); 7.5018 (5.0); 7.4961 (5.6); 7.4763 (5.6); 7.4707 (4.5); 7.2935 (3.4); 7.2766 (3.4); 7.2617 (1.9); 7.2488 (2.0); 7.2392 (2.0); 7.2342 (2.0); 7.2260 (2.1); 7.2212 (2.0); 7.2115 (1.9); 7.1986 (1.8); 7.0404 (1.2); 7.0348 (2.0); 7.0290 (1.0); 7.0174 (2.3); 7.0116 (3.9); 7.0058 (1.8); 6.9943 (1.3); 6.9884 (1.9); 6.7832 (1.2); 6.7741 (1.9); 6.7633 (1.6); 6.7541 (2.2); 6.7459 (1.4); 6.7320 (1.6); 6.7232 (0.8); 4.4072 (1.8); 4.3980 (1.6); 4.1563 (3.0); 4.1397 (3.2); 4.1305 (3.8); 4.1139 (2.9); 4.0560 (0.8); 4.0382 (2.2); 4.0204 (2.2); 4.0026 (0.6); 3.7204 (2.7); 3.7116 (2.7); 3.6949 (2.5); 3.6858 (2.4); 3.3177 (146.9); 3.2677 (1.2); 3.1139 (0.6); 3.0958 (0.6); 3.0840 (0.6); 3.0295 (3.2); 3.0098 (3.4); 2.9867 (3.8); 2.9670 (3.4); 2.6742 (2.1); 2.6695 (3.0); 2.6649 (2.1); 2.5230 (8.3); 2.5183 (12.4); 2.5097 (167.0); 2.5051 (361.6); 2.5005 (501.6); 2.4958 (348.5); 2.4912 (154.8); 2.4760 (4.8); 2.4554 (2.9); 2.4507 (3.7); 2.4442 (4.0); 2.4329 (2.8); 2.4006 (0.7); 2.3319 (2.3); 2.3272 (3.2); 2.3227 (2.2); 2.0724 (1.3); 1.9878 (10.2); 1.9079 (16.0); 1.2342 (0.6); 1.1924 (3.0); 1.1746 (6.4); 1.1568 (3.1); 0.0080 (3.9); -0.0002 (141.5); - 0.0085 (4.4); -0.0499 (0.8) I.4-58: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5964 (1.2); 8.4671 (0.8); 8.0371 (0.5); 8.0289 (1.1); 8.0208 (1.3); 8.0127 (0.9); 8.0045 (0.8); 8.0004 (1.2); 7.9923 (1.0); 7.9842 (0.7); 7.9760 (0.6); 7.7237 (1.7); 7.7177 (0.7); 7.7118 (3.2); 7.7064 (1.4); 7.7004 (4.5); 7.6945 (1.7); 7.6893 (3.7); 7.6831 (0.8); 7.6772 (2.6); 7.2741 (0.7); 7.2611 (1.0); 7.2524 (2.6); 7.2465 (1.6); 7.2419 (3.6); 7.2296 (3.1); 7.2201 (6.2); 7.2145 (2.2); 7.2078 (2.7); 7.1971 (3.4); 6.7891 (0.5); 6.7802 (0.7); 6.7670 (0.7); 6.7584 (1.2); 6.7499 (0.8); 6.7383 (1.1); 6.7301 (0.7); 4.1225 (0.7); 4.1089 (0.8); 4.0964 (1.3); 4.0825 (1.7); 4.0747 (2.0); 4.0624 (1.8); 4.0523 (0.6); 4.0442 (0.5); 3.6294 (0.8); 3.6247 (0.8); 3.6032 (0.8); 3.5987 (0.8); 3.5818 (1.4); 3.5760 (1.4); 3.3223 (86.8); 3.2727 (0.7); 3.1267 (0.8); 3.1146 (0.8); 3.1085 (2.5); 3.0964 (2.5); 3.0902 (2.6); 3.0782 (2.5); 3.0720 (0.8); 3.0600 (0.7); 2.9770 (0.8); 2.9590 (1.0); 2.9412 (0.8); 2.6745 (0.9); 2.6699 (1.3); 2.6653 (1.0); 2.6096 (0.8); 2.5912 (1.0); 2.5719 (0.7); 2.5344 (0.6); 2.5297 (0.6); 2.5234 (3.0); 2.5187 (4.6); 2.5100 (72.6); 2.5054 (160.5); 2.5008 (225.5); 2.4962 (156.9); 2.4916 (68.9); 2.4695 (0.7); 2.4602 (0.6); 2.4554 (1.1); 2.4508 (1.5); 2.4463 (1.1); 2.3322 (1.0); 2.3276 (1.4); 2.3230 (1.0); 2.0727 (0.8); 1.9083 (16.0); 1.2153 (8.4); 1.1976 (12.2); 1.1799 (10.4); 1.1617 (4.7); 1.1027 (4.6); 1.0844 (4.6); -0.0002 (12.7) I.4-59: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.6164 (1.1); 7.6119 (1.1); 7.6035 (1.4); 7.5985 (2.1); 7.5937 (1.5); 7.5908 (1.5); 7.5855 (1.8); 7.5807 (1.7); 7.5774 (2.0); 7.5725 (1.4); 7.5644 (1.4); 7.5597 (1.3); 7.5218 (1.6); 7.5176 (2.0); 7.5018 (4.9); 7.4982 (5.3); 7.4805 (4.1); 7.4773 (4.0); 7.4728 (2.4); 7.4652 (2.9); 7.4607 (2.5); 7.4549 (1.7); 7.4517 (1.7); 7.4472 (2.5); 7.4424 (2.4); 7.4136 (3.1); 7.4103 (2.9); 7.3950 (2.9); 7.3754 (1.6); 7.3720 (1.6); 7.3654 (1.0); 7.3624 (1.5); 7.3581 (1.4); 7.3524 (1.1); 7.3424 (3.5); 7.3380 (2.7); 7.3316 (1.9); 7.3272 (1.7); 7.3220 (1.0); 7.3160 (2.2); 7.3118 (2.8); 7.2955 (1.2); 7.2906 (0.8); 7.2846 (2.6); 7.2792 (1.5); 7.2675 (2.5); 7.2650 (2.2); 7.2624 (1.9); 7.2480 (2.0); 7.2428 (1.2); 5.7537 (16.0); 5.1190 (0.9); 5.0977 (1.3); 5.0739 (0.9); 4.2810 (1.3); 4.2553 (1.9); 4.2344 (1.5); 4.0036 (1.8); 3.9958 (1.7); 3.9773 (1.5); 3.9699 (1.4); 3.3785 (8.6); 3.0723 (1.8); 3.0477 (2.1); 3.0280 (2.9); 3.0034 (2.4); 2.8529 (2.0); 2.8439 (1.9); 2.8085 (1.3); 2.7998 (1.4); 2.6739 (1.2); 2.6693 (1.8); 2.6645 (1.4); 2.6602 (0.6); 2.5501 (0.5); 2.5228 (3.9); 2.5181 (5.7); 2.5094 (102.3); 2.5048 (227.3); 2.5002 (322.9); 2.4955 (224.9); 2.4909 (99.5); 2.4651 (1.2); 2.4595 (1.3); 2.4548 (1.7); 2.4502 (2.1); 2.4455 (1.6); 2.4003 (0.6); 2.3363 (0.9); 2.3315 (1.5); 2.3269 (2.1); 2.3223 (1.5); 0.1460 (0.5); 0.0081 (5.1); 0.0041 (0.9); -0.0002 (221.5); -0.0086 (6.8); -0.0300 (0.6); -0.0501 (1.0); -0.1496 (0.6) I.4-60: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.7261 (1.8); 7.7220 (2.9); 7.7188 (2.6); 7.7086 (1.9); 7.7055 (2.5); 7.7034 (3.8); 7.7004 (2.3); 7.6166 (1.0); 7.6066 (1.6); 7.6024 (1.7); 7.5897 (3.0); 7.5830 (3.4); 7.5714 (3.8); 7.5650 (3.3); 7.5539 (3.2); 7.5520 (3.4); 7.5499 (3.7); 7.5478 (3.5); 7.5361 (2.7); 7.5342 (2.9); 7.5291 (6.1); 7.5241 (3.9); 7.5136 (2.7); 7.5101 (3.5); 7.5044 (2.0); 7.4941 (2.4); 7.4903 (1.9); 7.4745 (1.0); 7.4704 (1.2); 7.3644 (1.4); 7.3438 (4.5); 7.3388 (3.2); 7.3311 (1.6); 7.3168 (2.3); 7.3126 (2.9); 7.2958 (1.2); 7.2863 (1.6); 7.2826 (1.9); 7.2660 (2.4); 7.2496 (1.1); 7.2464 (1.2); 5.7537 (16.0); 5.1308 (0.9); 5.1094 (1.3); 5.0853 (1.0); 4.2966 (1.5); 4.2711 (2.0); 4.2500 (1.6); 4.0603 (1.4); 4.0525 (1.2); 4.0337 (1.1); 4.0259 (1.1); 3.9648 (1.3); 3.9572 (1.3); 3.9387 (1.1); 3.9309 (1.1); 3.3105 (122.6); 3.2604 (0.8); 3.0927 (1.9); 3.0823 (1.8); 3.0681 (1.8); 3.0577 (1.6); 3.0484 (1.8); 3.0377 (1.9); 3.0238 (1.4); 3.0131 (1.5); 2.9080 (1.5); 2.8994 (1.6); 2.8639 (1.0); 2.8550 (1.0); 2.8177 (1.5); 2.8089 (1.4); 2.7736 (1.0); 2.7645 (1.2); 2.6739 (2.0); 2.6693 (2.7); 2.6646 (1.9); 2.5228 (7.2); 2.5181 (10.4); 2.5094 (150.0); 2.5048 (327.1); 2.5002 (459.8); 2.4955 (318.0); 2.4909 (138.3); 2.4549 (2.0); 2.4503 (2.6); 2.4456 (1.8); 2.4005 (0.7); 2.3317 (2.0); 2.3270 (2.8); 2.3223 (2.0); 1.2338 (0.7); 1.1872 (2.8); 1.1692 (5.2); 1.1513 (2.7); 0.1464 (0.6); 0.0081 (6.3); - 0.0002 (244.3); -0.0086 (7.1); -0.0500 (1.2); -0.1499 (0.8) I.4-61: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.7245 (2.7); 7.7208 (2.6); 7.7137 (1.2); 7.7100 (1.7); 7.7064 (3.7); 7.7036 (3.0); 7.7017 (2.4); 7.6969 (1.0); 7.6945 (1.6); 7.6920 (1.0); 7.6826 (2.4); 7.6797 (3.2); 7.6752 (3.0); 7.6724 (3.3); 7.6675 (2.2); 7.6605 (3.6); 7.6579 (3.6); 7.6532 (4.0); 7.6505 (4.3); 7.6282 (2.0); 7.6254 (1.7); 7.6168 (1.0); 7.6082 (1.9); 7.5997 (1.2); 7.5939 (2.2); 7.5916 (2.0); 7.5848 (3.6); 7.5810 (1.4); 7.5762 (2.4); 7.5710 (3.0); 7.5656 (3.8); 7.5577 (3.9); 7.5555 (4.0); 7.5535 (4.2); 7.5519 (4.6); 7.5486 (3.4); 7.5468 (3.1); 7.5413 (4.5); 7.5381 (3.7); 7.5276 (1.3); 7.5239 (2.6); 7.5209 (3.2); 7.5109 (2.0); 7.5085 (1.8); 7.5050 (1.0); 7.4991 (0.6); 7.4238 (2.6); 7.4216 (2.9); 7.4112 (1.6); 7.4052 (3.9); 7.4028 (4.7); 7.3929 (1.6); 7.3890 (1.7); 7.3837 (3.8); 7.3814 (2.7); 7.3713 (1.5); 7.3660 (1.9); 7.3445 (1.5); 7.1991 (0.6); 7.1877 (1.6); 7.1855 (1.6); 7.1692 (2.6); 7.1673 (2.7); 7.1507 (1.2); 7.1484 (1.2); 7.1391 (0.8); 7.1208 (1.4); 7.1023 (0.7); 5.7536 (16.0); 5.1207 (0.6); 5.1001 (0.9); 5.0807 (0.6); 4.7360 (0.7); 4.7195 (1.9); 4.7014 (1.7); 4.6804 (1.0); 4.3925 (0.5); 4.3736 (0.6); 4.3633 (1.0); 4.3522 (0.6); 4.3453 (0.5); 4.2238 (0.9); 4.1980 (1.6); 4.1924 (1.9); 4.1838 (1.8); 4.1765 (1.4); 4.1719 (1.8); 4.1666 (1.8); 4.1045 (1.2); 4.0890 (1.2); 4.0790 (0.8); 4.0634 (0.8); 4.0123 (1.3); 3.9841 (1.1); 3.3096 (79.7); 3.2600 (0.7); 3.2391 (1.0); 3.2330 (1.3); 3.2149 (2.1); 3.1970 (1.5); 3.1743 (1.3); 3.1560 (2.0); 3.1378 (1.3); 3.1008 (0.7); 3.0824 (0.6); 2.6739 (1.2); 2.6692 (1.6); 2.6645 (1.1); 2.5227 (3.8); 2.5180 (5.6); 2.5093 (83.8); 2.5048 (183.4); 2.5001 (258.6); 2.4955 (178.7); 2.4909 (77.9); 2.4669 (0.8); 2.4550 (1.3); 2.4505 (1.6); 2.4460 (1.2); 2.3363 (0.6); 2.3317 (1.1); 2.3269 (1.7); 2.3223 (1.1); 2.0953 (0.6); 1.2985 (12.8); 1.2803 (12.4); 1.2348 (0.5); 1.1916 (1.8); 1.1735 (3.5); 1.1554 (1.7); 1.1081 (3.6); 1.0928 (3.5); 1.0897 (4.0); 1.0745 (2.9); 0.0081 (4.7); 0.0057 (1.3); 0.0049 (1.5); 0.0040 (2.0); -0.0002 (169.9); -0.0057 (1.7); -0.0066 (1.4); -0.0086 (4.7); - 0.0495 (0.7) I.4-62: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.7424 (0.5); 7.7161 (0.5); 7.7081 (4.8); 7.7025 (1.4); 7.6909 (1.6); 7.6852 (6.0); 7.6773 (0.6); 7.6060 (0.5); 7.6013 (0.6); 7.5931 (0.6); 7.5880 (1.0); 7.5850 (0.7); 7.5831 (0.8); 7.5803 (0.7); 7.5752 (0.7); 7.5702 (0.8); 7.5669 (1.0); 7.5620 (0.7); 7.5542 (0.6); 7.5492 (0.6); 7.5212 (0.7); 7.4985 (0.8); 7.4878 (1.0); 7.4846 (1.2); 7.4718 (0.9); 7.4638 (7.3); 7.4584 (2.7); 7.4466 (1.8); 7.4412 (7.0); 7.4332 (0.6); 7.4241 (1.2); 7.4191 (1.0); 7.3991 (1.6); 7.3958 (1.4); 7.3809 (1.3); 7.3779 (1.3); 7.3612 (0.6); 7.3577 (0.6); 5.7537 (16.0); 5.0406 (0.6); 5.0374 (0.6); 4.3596 (0.9); 4.3390 (1.1); 4.3322 (1.3); 4.3117 (1.0); 4.0592 (0.8); 4.0528 (0.8); 4.0316 (0.7); 4.0256 (0.7); 3.4163 (2.1); 3.1549 (0.9); 3.1302 (1.1); 3.1102 (1.4); 3.0855 (1.2); 2.9000 (1.0); 2.8925 (0.9); 2.8554 (0.7); 2.8482 (0.7); 2.6693 (0.6); 2.5228 (1.3); 2.5181 (2.0); 2.5094 (28.9); 2.5048 (63.4); 2.5002 (89.4); 2.4956 (61.6); 2.4910 (26.7); 2.4502 (0.5); 2.3270 (0.5); 1.1777 (0.7); 0.0080 (1.5); -0.0002 (61.9); -0.0060 (0.5); -0.0085 (1.8) I.4-63: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1391 (8.0); 8.1359 (9.6); 8.1327 (8.3); 8.1305 (5.8); 8.0396 (2.3); 8.0340 (2.3); 8.0282 (3.2); 8.0220 (3.3); 8.0158 (3.2); 8.0138 (3.8); 8.0100 (3.2); 8.0017 (2.6); 7.9960 (2.3); 7.9865 (0.5); 7.7700 (0.6); 7.7187 (3.6); 7.7146 (5.1); 7.7112 (3.8); 7.7068 (5.4); 7.7002 (4.1); 7.6987 (4.4); 7.6947 (5.3); 7.6916 (4.3); 7.6881 (4.7); 7.6457 (1.0); 7.6265 (16.0); 7.6244 (14.6); 7.6216 (6.7); 7.6172 (7.4); 7.6143 (13.7); 7.6122 (14.7); 7.5984 (3.9); 7.5933 (5.3); 7.5800 (9.4); 7.5750 (8.7); 7.5613 (8.1); 7.5555 (9.6); 7.5522 (3.6); 7.5438 (5.5); 7.5395 (6.5); 7.5374 (5.4); 7.5333 (5.7); 7.5254 (3.1); 7.5211 (2.7); 7.5190 (3.5); 7.5150 (2.9); 7.5027 (10.7); 7.4982 (8.2); 7.4965 (8.0); 7.4840 (5.7); 7.4785 (4.2); 5.7537 (8.8); 5.0951 (1.5); 5.0896 (1.6); 5.0706 (3.0); 5.0504 (1.8); 4.4234 (2.1); 4.4154 (2.2); 4.4034 (2.6); 4.3953 (5.1); 4.3876 (3.2); 4.3757 (2.4); 4.3674 (2.3); 4.1889 (2.5); 4.1829 (2.6); 4.1613 (2.2); 4.1553 (2.0); 4.0692 (2.4); 4.0634 (2.4); 4.0413 (2.2); 4.0356 (2.1); 3.3107 (139.9); 3.2614 (0.9); 3.2255 (2.2); 3.2073 (2.2); 3.2010 (2.7); 3.1808 (3.8); 3.1624 (3.5); 3.1562 (2.9); 3.1383 (2.8); 3.1144 (0.9); 3.1025 (1.0); 3.0959 (0.8); 3.0845 (0.9); 3.0027 (3.0); 2.9956 (2.9); 2.9579 (2.0); 2.9510 (2.1); 2.8910 (2.8); 2.8842 (2.8); 2.8463 (2.2); 2.8395 (2.2); 2.6740 (2.0); 2.6694 (2.8); 2.6648 (2.0); 2.6601 (0.9); 2.5504 (0.6); 2.5229 (6.2); 2.5182 (9.4); 2.5095 (153.5); 2.5049 (338.6); 2.5003 (478.6); 2.4957 (332.0); 2.4910 (145.7); 2.4552 (2.6); 2.4504 (3.1); 2.4459 (2.2); 2.3317 (2.2); 2.3271 (3.0); 2.3224 (2.1); 2.0725 (1.1); 1.2346 (0.7); 1.1939 (2.6); 1.1757 (5.2); 1.1575 (2.4); 0.1460 (0.8); 0.0126 (0.6); 0.0119 (0.8); 0.0110 (1.0); 0.0103 (1.1); 0.0080 (9.1); 0.0063 (2.5); 0.0055 (2.7); 0.0047 (3.2); 0.0039 (4.1); 0.0022 (11.8); -0.0002 (312.7); -0.0027 (14.3); -0.0035 (9.1); -0.0043 (5.2); -0.0052 (3.7); -0.0060 (3.0); -0.0068 (2.7); -0.0085 (9.0); -0.0107 (1.4); -0.0115 (1.3); -0.0124 (1.1); -0.0132 (1.0); -0.0139 (1.0); -0.0148 (0.9); -0.0155 (0.8); -0.0164 (0.8); -0.0171 (0.6); -0.0179 (0.6); -0.0187 (0.7); -0.0203 (0.6); -0.0211 (0.5); -0.0330 (0.7); - 0.0500 (1.1); -0.1496 (0.9) I.4-64: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.7639 (2.7); 8.5660 (1.5); 7.6080 (2.4); 7.6033 (2.9); 7.5951 (2.7); 7.5899 (5.7); 7.5851 (4.0); 7.5823 (3.7); 7.5773 (3.4); 7.5722 (4.1); 7.5689 (6.1); 7.5640 (3.8); 7.5563 (3.4); 7.5513 (3.4); 7.4964 (2.7); 7.4898 (7.7); 7.4850 (12.4); 7.4791 (12.4); 7.4687 (5.9); 7.4642 (11.2); 7.4595 (16.0); 7.4537 (13.5); 7.4429 (6.6); 7.4390 (9.5); 7.4341 (6.9); 7.4211 (7.1); 7.4158 (6.0); 7.4007 (10.1); 7.3975 (8.7); 7.3827 (7.9); 7.3795 (7.8); 7.3629 (3.7); 7.3594 (3.6); 7.0539 (2.4); 7.0482 (4.2); 7.0425 (2.1); 7.0308 (5.2); 7.0251 (8.3); 7.0193 (3.9); 7.0079 (2.5); 7.0019 (4.1); 6.9961 (1.9); 5.7537 (3.1); 5.0613 (2.9); 5.0550 (2.1); 5.0409 (4.3); 5.0372 (4.1); 5.0226 (2.1); 5.0165 (2.9); 4.3656 (5.6); 4.3452 (6.5); 4.3376 (7.7); 4.3175 (5.9); 4.0760 (5.0); 4.0708 (4.9); 4.0480 (4.3); 3.3160 (188.2); 3.2660 (1.8); 3.2178 (5.6); 3.1931 (6.5); 3.1727 (8.0); 3.1481 (6.7); 2.9215 (5.4); 2.9150 (5.4); 2.8764 (4.2); 2.8699 (4.1); 2.6740 (3.5); 2.6694 (5.0); 2.6647 (3.4); 2.6602 (1.6); 2.5229 (12.2); 2.5182 (18.1); 2.5095 (260.3); 2.5049 (570.0); 2.5003 (804.0); 2.4956 (554.9); 2.4910 (247.1); 2.4549 (4.4); 2.4502 (5.6); 2.4458 (4.2); 2.3318 (3.6); 2.3271 (4.8); 2.3224 (3.5); 2.0724 (1.8); 1.1762 (1.0); 0.1458 (1.3); 0.0126 (1.0); 0.0118 (1.1); 0.0080 (15.7); 0.0063 (4.1); 0.0055 (4.4); 0.0046 (5.5); 0.0038 (7.4); 0.0022 (21.1); -0.0002 (556.5); -0.0028 (22.8); -0.0035 (14.4); -0.0044 (8.4); -0.0052 (6.3); -0.0060 (5.2); -0.0068 (4.5); -0.0085 (15.9); -0.0108 (2.4); -0.0116 (2.1); -0.0124 (1.9); -0.0132 (1.6); -0.0140 (1.5); -0.0148 (1.4); -0.0156 (1.2); -0.0164 (0.9); -0.0172 (1.0); -0.0180 (0.9); -0.0188 (0.9); -0.0291 (0.9); -0.0503 (2.7); -0.1495 (1.5) I.4-65: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0516 (3.6); 8.0459 (3.6); 7.7469 (3.5); 7.5139 (2.5); 7.5082 (2.8); 7.4884 (2.9); 7.4827 (2.4); 7.3064 (1.8); 7.2899 (1.8); 7.1473 (2.3); 7.1458 (2.3); 7.1270 (2.7); 7.1256 (2.7); 7.0415 (0.6); 7.0357 (1.0); 7.0183 (1.2); 7.0126 (2.1); 7.0068 (1.0); 6.9951 (0.7); 6.9894 (1.1); 6.9218 (2.4); 6.9161 (2.3); 6.9016 (2.0); 6.8960 (1.9); 4.4119 (0.5); 4.4041 (0.7); 4.3948 (0.8); 4.3862 (0.8); 4.3782 (0.6); 4.1589 (1.5); 4.1426 (1.6); 4.1330 (1.9); 4.1168 (1.4); 3.7256 (1.3); 3.7171 (1.3); 3.6998 (1.2); 3.6915 (1.2); 3.3159 (263.8); 3.2654 (1.6); 3.0415 (1.5); 3.0219 (1.7); 2.9987 (1.9); 2.9792 (1.7); 2.6746 (0.6); 2.6700 (0.9); 2.6655 (0.6); 2.5235 (1.7); 2.5188 (2.6); 2.5101 (47.1); 2.5055 (104.4); 2.5009 (147.8); 2.4963 (103.2); 2.4916 (45.6); 2.4755 (2.0); 2.4553 (0.8); 2.4506 (1.1); 2.4425 (1.6); 2.4325 (1.4); 2.3323 (0.7); 2.3277 (0.9); 2.3230 (0.7); 2.1402 (16.0); 2.0727 (0.6); 1.1771 (0.8); 0.0081 (1.5); -0.0002 (53.9); -0.0085 (1.5) I.4-66: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1051 (2.4); 8.0995 (2.4); 8.0591 (3.6); 8.0535 (3.4); 7.8691 (3.6); 7.7495 (2.8); 7.7436 (3.2); 7.7373 (2.9); 7.7317 (1.6); 7.7263 (2.8); 7.7216 (3.7); 7.7141 (2.9); 7.7093 (3.6); 7.7041 (1.8); 7.6984 (3.7); 7.6918 (1.1); 7.6860 (3.5); 7.2549 (2.7); 7.2489 (1.1); 7.2431 (4.2); 7.2372 (2.3); 7.2318 (5.2); 7.2273 (3.4); 7.2213 (6.2); 7.2158 (3.3); 7.2102 (3.7); 7.2044 (2.2); 7.1984 (3.9); 7.1592 (2.4); 7.1375 (4.3); 7.1173 (1.9); 6.9292 (2.4); 6.9236 (2.3); 6.9090 (2.1); 6.9039 (2.6); 6.8997 (1.7); 6.8850 (1.4); 6.8795 (1.4); 4.5174 (0.6); 4.5035 (0.7); 4.1284 (1.0); 4.1149 (1.2); 4.1025 (2.2); 4.0888 (1.3); 4.0841 (2.7); 4.0674 (2.6); 4.0554 (1.2); 4.0380 (0.8); 3.6312 (1.2); 3.6268 (1.1); 3.6007 (1.5); 3.5861 (1.7); 3.5797 (1.8); 3.3113 (250.1); 3.2811 (0.5); 3.2785 (0.7); 3.2618 (1.6); 3.1107 (1.6); 3.0988 (1.7); 3.0925 (1.7); 3.0804 (1.6); 3.0623 (0.5); 2.9801 (1.2); 2.9624 (1.6); 2.9445 (1.1); 2.6743 (1.3); 2.6696 (1.8); 2.6650 (1.3); 2.6165 (1.0); 2.5986 (1.3); 2.5786 (1.1); 2.5231 (3.8); 2.5184 (5.8); 2.5098 (97.6); 2.5052 (215.8); 2.5005 (302.6); 2.4959 (211.6); 2.4913 (94.1); 2.4552 (2.0); 2.4507 (2.4); 2.4461 (1.8); 2.4004 (0.5); 2.3319 (1.4); 2.3273 (1.9); 2.3227 (1.3); 2.2555 (1.6); 2.1703 (16.0); 2.1319 (11.1); 2.0725 (2.5); 1.2243 (11.0); 1.2065 (10.8); 1.1964 (4.3); 1.1782 (8.6); 1.1600 (4.0); 1.1140 (6.9); 1.0957 (6.8); 0.0080 (3.1); 0.0055 (0.8); -0.0002 (116.9); -0.0068 (1.3); -0.0085 (3.5); -0.0499 (0.7) I.4-67: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2529 (0.5); 8.1767 (2.9); 8.1726 (3.1); 8.1588 (4.3); 8.1562 (5.3); 8.1520 (3.6); 7.7285 (1.9); 7.7122 (1.9); 7.5637 (0.6); 7.5573 (5.8); 7.5525 (1.8); 7.5409 (1.9); 7.5360 (6.6); 7.5295 (0.7); 7.3449 (0.8); 7.3416 (1.0); 7.3310 (1.4); 7.2920 (2.0); 7.2717 (4.8); 7.2512 (3.7); 7.2244 (4.6); 7.2203 (5.3); 7.2043 (3.1); 7.2002 (3.0); 7.1950 (4.8); 7.1746 (4.3); 7.0247 (0.6); 7.0045 (1.1); 6.9845 (0.9); 6.7524 (0.7); 6.7488 (1.2); 6.7350 (1.3); 6.7315 (1.4); 6.7281 (1.0); 6.7155 (1.1); 6.7119 (0.8); 5.6679 (0.7); 4.3999 (0.6); 4.3922 (0.8); 4.3832 (0.9); 4.3744 (0.8); 4.3658 (0.6); 4.1569 (1.8); 4.1410 (1.9); 4.1312 (2.2); 4.1154 (1.7); 3.6661 (1.6); 3.6581 (1.5); 3.6404 (1.4); 3.6325 (1.4); 3.3147 (96.5); 3.0905 (0.9); 3.0730 (0.9); 2.9805 (1.7); 2.9612 (1.9); 2.9382 (2.1); 2.9188 (1.9); 2.5241 (1.0); 2.5194 (1.5); 2.5108 (19.9); 2.5062 (42.7); 2.5016 (59.1); 2.4970 (40.8); 2.4924 (18.0); 2.4086 (1.6); 2.3989 (1.5); 2.3662 (1.4); 2.3567 (1.4); 2.2805 (16.0); 1.2332 (0.6); 1.2011 (3.3); 1.1829 (6.9); 1.1646 (3.3) I.4-68: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.0261 (0.6); 8.2185 (2.1); 8.2119 (2.0); 8.1713 (0.7); 8.1147 (1.1); 8.1104 (1.1); 8.0939 (2.2); 8.0897 (2.1); 8.0732 (1.2); 8.0690 (1.1); 7.5484 (5.6); 7.5435 (1.8); 7.5318 (2.0); 7.5270 (6.4); 7.2352 (0.5); 7.2151 (0.7); 7.2017 (2.2); 7.1930 (6.0); 7.1764 (3.0); 7.1714 (4.9); 7.1641 (2.0); 7.1471 (1.9); 7.1435 (2.0); 7.1018 (1.0); 7.0828 (1.9); 7.0634 (1.1); 6.9661 (0.9); 6.9617 (0.9); 6.9531 (1.0); 6.9488 (1.2); 6.9414 (0.9); 6.9303 (1.0); 6.9227 (0.6); 6.9142 (0.5); 6.9098 (0.5); 4.3963 (0.6); 4.3884 (0.9); 4.3790 (0.9); 4.3706 (0.9); 4.1415 (1.8); 4.1253 (1.9); 4.1161 (2.2); 4.0999 (1.8); 3.6542 (1.6); 3.6456 (1.6); 3.6287 (1.4); 3.6202 (1.4); 3.3111 (267.5); 3.2612 (0.7); 2.9559 (1.8); 2.9364 (2.0); 2.9137 (2.2); 2.8942 (1.9); 2.6744 (0.7); 2.6697 (1.0); 2.6652 (0.8); 2.5230 (3.1); 2.5183 (4.7); 2.5097 (60.6); 2.5051 (130.2); 2.5005 (180.0); 2.4959 (124.1); 2.4913 (54.8); 2.4062 (1.7); 2.3958 (1.7); 2.3641 (1.5); 2.3534 (1.4); 2.3320 (0.8); 2.3274 (1.1); 2.3227 (0.7); 2.2791 (16.0); 1.9876 (0.8); 1.1922 (1.0); 1.1744 (2.0); 1.1564 (0.9); -0.0002 (1.1) I.4-69: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5179 (3.2); 7.4518 (5.0); 7.4306 (5.7); 7.3244 (0.6); 7.3123 (0.6); 7.2590 (577.6); 7.2324 (0.8); 7.2168 (1.0); 7.2100 (1.5); 7.1960 (2.0); 7.1709 (4.6); 7.1504 (3.8); 6.9950 (3.3); 6.9848 (3.5); 6.9650 (4.4); 6.9444 (2.3); 5.9592 (1.7); 5.1915 (1.0); 4.6158 (0.9); 4.2085 (2.0); 4.1928 (1.9); 4.1820 (2.4); 4.1663 (2.2); 3.8132 (1.9); 3.8054 (1.7); 3.7870 (1.6); 3.7790 (1.4); 3.0463 (1.7); 3.0264 (1.9); 3.0030 (2.2); 2.9828 (2.0); 2.4950 (1.6); 2.4852 (1.6); 2.4517 (1.4); 2.4421 (1.4); 2.3208 (16.0); 1.5350 (211.8); 1.4859 (0.6); 1.4214 (1.0); 1.4032 (1.8); 1.3849 (0.8); 0.1459 (0.8); 0.0079 (8.3); -0.0002 (221.0); -0.0085 (6.8); -0.1496 (0.8) I.4-70: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8196 (1.9); 7.8016 (2.1); 7.6177 (3.3); 7.5239 (0.5); 7.5123 (2.5); 7.5065 (2.8); 7.4867 (2.9); 7.4811 (2.4); 7.1358 (1.8); 7.1246 (2.1); 7.1193 (1.9); 7.1078 (2.6); 7.0904 (1.7); 7.0708 (1.0); 7.0386 (0.6); 7.0328 (1.0); 7.0271 (0.5); 7.0154 (1.2); 7.0096 (2.0); 7.0038 (1.0); 6.9923 (0.6); 6.9864 (1.0); 6.9016 (1.3); 6.8986 (1.3); 6.8831 (2.2); 6.8801 (2.1); 6.8645 (0.9); 6.8615 (0.9); 4.4116 (0.6); 4.4039 (0.8); 4.3948 (0.8); 4.3856 (0.8); 4.3782 (0.6); 4.1520 (1.5); 4.1356 (1.6); 4.1262 (1.9); 4.1099 (1.5); 3.7125 (1.4); 3.7040 (1.4); 3.6868 (1.2); 3.6783 (1.2); 3.3136 (102.1); 3.2631 (0.8); 3.0262 (1.6); 3.0065 (1.7); 2.9834 (2.0); 2.9638 (1.7); 2.6697 (0.7); 2.6650 (0.5); 2.5232 (1.6); 2.5185 (2.5); 2.5098 (41.2); 2.5052 (90.7); 2.5006 (127.1); 2.4960 (89.5); 2.4914 (40.2); 2.4751 (2.0); 2.4551 (1.0); 2.4505 (1.3); 2.4427 (1.7); 2.4323 (1.4); 2.3320 (0.6); 2.3274 (0.8); 2.3227 (0.6); 2.1611 (16.0); 1.1949 (0.8); 1.1766 (1.6); 1.1586 (0.8); 0.0080 (1.7); -0.0002 (62.2); -0.0068 (0.8); -0.0085 (2.0) I.4-71: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1645 (8.0); 8.1606 (8.2); 8.1436 (8.9); 8.1397 (8.6); 8.0370 (12.3); 7.6441 (6.1); 7.6280 (5.9); 7.5028 (3.2); 7.4985 (3.8); 7.4830 (6.9); 7.4789 (7.2); 7.4634 (4.1); 7.4592 (4.3); 7.4188 (9.1); 7.4152 (9.4); 7.3988 (10.1); 7.3951 (10.0); 7.3739 (1.0); 7.3645 (1.7); 7.3573 (3.6); 7.3530 (3.6); 7.3470 (2.7); 7.3402 (10.7); 7.3370 (6.7); 7.3344 (7.3); 7.3264 (5.0); 7.3221 (4.4); 7.3127 (5.3); 7.3084 (7.1); 7.2920 (2.6); 7.2874 (1.8); 7.2742 (6.3); 7.2682 (7.5); 7.2645 (4.5); 7.2571 (6.5); 7.2548 (5.9); 7.2500 (8.7); 7.2476 (8.3); 7.2378 (5.3); 7.2323 (3.6); 7.2291 (4.6); 7.2253 (4.2); 6.9886 (6.6); 6.9846 (6.8); 6.9701 (7.0); 6.9686 (6.8); 6.9662 (6.9); 6.9646 (6.8); 6.9501 (5.6); 6.9462 (5.4); 4.4508 (2.0); 4.4436 (2.7); 4.4349 (3.2); 4.4254 (2.7); 4.4188 (2.2); 4.1185 (4.5); 4.1024 (4.5); 4.0947 (5.4); 4.0788 (4.5); 4.0559 (1.2); 4.0381 (3.0); 4.0204 (3.1); 4.0025 (1.1); 3.6109 (5.0); 3.6021 (4.9); 3.5862 (4.7); 3.5772 (4.6); 3.3980 (0.7); 3.3658 (2.5); 3.3165 (697.7); 3.2857 (1.5); 3.2663 (6.6); 3.2159 (1.0); 3.1128 (1.8); 3.1008 (1.9); 3.0946 (2.1); 3.0825 (1.9); 3.0644 (0.6); 2.9360 (6.1); 2.9164 (6.7); 2.8935 (7.6); 2.8740 (6.6); 2.6745 (2.7); 2.6699 (3.8); 2.6652 (2.7); 2.5886 (0.7); 2.5444 (3.6); 2.5234 (10.0); 2.5187 (13.8); 2.5100 (198.0); 2.5054 (436.7); 2.5008 (616.8); 2.4962 (434.7); 2.4916 (196.9); 2.4557 (5.1); 2.4511 (7.1); 2.4465 (5.8); 2.3704 (5.8); 2.3597 (5.7); 2.3277 (8.6); 2.3230 (3.6); 2.3176 (5.8); 2.0727 (2.4); 1.9880 (14.6); 1.9083 (16.0); 1.1954 (3.7); 1.1923 (4.8); 1.1772 (7.7); 1.1746 (9.5); 1.1589 (3.8); 1.1568 (5.1); 0.1462 (0.8); 0.0080 (7.5); 0.0064 (2.0); 0.0055 (2.2); 0.0047 (2.8); -0.0002 (258.2); -0.0067 (4.0); -0.0085 (8.2); - 0.0499 (1.8); -0.1498 (0.8) I.4-72: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1972 (3.7); 8.1933 (3.7); 8.1763 (4.0); 8.1724 (3.9); 8.1675 (2.9); 8.1637 (3.1); 8.1467 (3.2); 8.1429 (3.2); 8.0904 (4.7); 8.0344 (5.4); 7.7455 (5.4); 7.7396 (1.8); 7.7332 (6.0); 7.7276 (3.1); 7.7222 (6.3); 7.7180 (5.0); 7.7099 (6.2); 7.7057 (5.0); 7.7004 (2.6); 7.6948 (5.0); 7.6883 (1.5); 7.6824 (4.7); 7.5243 (2.0); 7.5083 (2.0); 7.4937 (2.8); 7.4725 (2.7); 7.4238 (3.5); 7.4202 (3.5); 7.4034 (4.7); 7.4019 (5.2); 7.3986 (5.4); 7.3819 (4.5); 7.3783 (4.7); 7.2733 (1.7); 7.2698 (1.7); 7.2638 (2.4); 7.2598 (2.5); 7.2559 (7.7); 7.2505 (3.8); 7.2431 (8.3); 7.2387 (4.5); 7.2343 (10.1); 7.2211 (8.3); 7.2171 (2.7); 7.2113 (6.0); 7.2042 (1.6); 7.1984 (4.5); 6.9962 (2.5); 6.9922 (2.7); 6.9777 (2.9); 6.9762 (2.8); 6.9737 (5.4); 6.9696 (3.5); 6.9578 (2.6); 6.9551 (3.7); 6.9537 (5.1); 6.9512 (3.3); 6.9497 (3.4); 6.9352 (2.7); 6.9312 (2.6); 5.7535 (1.3); 4.5401 (0.7); 4.5238 (1.4); 4.5096 (1.5); 4.4924 (0.7); 4.1283 (2.4); 4.1147 (2.7); 4.1071 (1.6); 4.1024 (3.3); 4.0888 (5.6); 4.0770 (1.9); 4.0710 (3.2); 4.0563 (1.9); 4.0383 (2.7); 4.0205 (2.2); 4.0026 (0.7); 3.6300 (2.7); 3.6255 (2.8); 3.6040 (2.7); 3.5994 (3.0); 3.5836 (2.4); 3.5772 (2.4); 3.5646 (0.7); 3.4000 (0.8); 3.3657 (2.5); 3.3510 (1.1); 3.3486 (1.4); 3.3169 (717.5); 3.2888 (1.3); 3.2835 (1.0); 3.2667 (5.7); 3.2553 (0.9); 3.2164 (1.0); 3.1983 (0.6); 2.9942 (0.7); 2.9760 (2.7); 2.9581 (3.6); 2.9404 (2.6); 2.9226 (0.6); 2.6747 (1.4); 2.6702 (2.0); 2.6655 (1.5); 2.6028 (1.5); 2.5847 (2.1); 2.5649 (1.4); 2.5505 (1.8); 2.5236 (5.8); 2.5190 (8.2); 2.5103 (108.8); 2.5057 (238.6); 2.5010 (336.1); 2.4964 (232.6); 2.4918 (101.4); 2.4557 (2.6); 2.4511 (3.1); 2.4464 (2.2); 2.4006 (0.7); 2.3325 (1.6); 2.3278 (2.1); 2.3232 (1.5); 1.9881 (10.2); 1.9085 (2.2); 1.2267 (14.8); 1.2088 (14.3); 1.1925 (3.4); 1.1746 (6.5); 1.1569 (3.1); 1.1133 (16.0); 1.0950 (15.8); 0.8755 (0.6); 0.8583 (2.7); 0.8406 (0.8); -0.0002 (19.2); -0.0085 (0.6) I.4-73: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2316 (10.1); 8.2259 (10.1); 8.1741 (0.6); 8.1068 (5.1); 8.1026 (5.5); 8.0860 (10.6); 8.0819 (10.7); 8.0653 (6.0); 8.0613 (5.6); 7.5221 (1.4); 7.5151 (2.5); 7.5035 (13.5); 7.4978 (15.6); 7.4780 (16.0); 7.4723 (13.4); 7.4669 (3.0); 7.4606 (2.5); 7.4535 (1.5); 7.2010 (8.3); 7.1973 (14.2); 7.1805 (15.0); 7.1776 (13.6); 7.1720 (7.3); 7.1684 (7.2); 7.1516 (7.1); 7.1480 (7.8); 7.1029 (4.6); 7.0869 (9.3); 7.0669 (5.8); 7.0381 (3.3); 7.0323 (5.6); 7.0266 (2.9); 7.0150 (6.4); 7.0092 (10.9); 7.0034 (5.5); 6.9918 (3.6); 6.9860 (5.7); 6.9804 (2.8); 6.9726 (4.7); 6.9683 (4.8); 6.9598 (5.0); 6.9554 (6.1); 6.9481 (4.9); 6.9410 (5.3); 6.9367 (5.3); 6.9293 (3.1); 6.9208 (3.0); 6.9165 (2.9); 4.4292 (1.6); 4.4198 (2.8); 4.4121 (4.1); 4.4030 (4.6); 4.3942 (4.2); 4.3863 (3.0); 4.3765 (2.1); 4.1531 (8.5); 4.1366 (8.9); 4.1274 (10.8); 4.1109 (8.3); 4.0383 (1.4); 4.0205 (1.3); 3.7144 (7.5); 3.7054 (7.5); 3.6887 (7.0); 3.6797 (6.8); 3.3623 (3.4); 3.3462 (0.8); 3.3403 (0.7); 3.3121 (330.1); 3.2858 (1.9); 3.2791 (0.8); 3.2624 (5.7); 3.2130 (0.6); 3.1941 (0.7); 3.0230 (8.8); 3.0032 (9.4); 2.9802 (10.9); 2.9605 (9.8); 2.6746 (2.0); 2.6700 (2.9); 2.6653 (2.1); 2.5557 (3.3); 2.5510 (4.9); 2.5464 (3.4); 2.5289 (0.8); 2.5236 (6.1); 2.5188 (9.0); 2.5101 (156.2); 2.5055 (346.7); 2.5009 (491.5); 2.4963 (348.4); 2.4917 (160.0); 2.4746 (14.2); 2.4603 (5.2); 2.4558 (7.9); 2.4512 (10.0); 2.4464 (8.3); 2.4423 (11.1); 2.4317 (8.6); 2.4010 (1.6); 2.3818 (1.5); 2.3324 (2.4); 2.3277 (3.3); 2.3230 (2.4); 2.0730 (2.1); 1.9881 (6.4); 1.9085 (6.7); 1.2333 (0.8); 1.1925 (2.0); 1.1748 (4.0); 1.1569 (2.1); 0.1460 (0.8); 0.0499 (2.2); 0.0081 (7.6); -0.0002 (282.6); -0.0086 (9.1); -0.0500 (4.0); -0.1198 (0.6); -0.1495 (0.8) I.4-74: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1649 (2.9); 8.1611 (3.2); 8.1571 (2.1); 8.1547 (3.7); 8.1517 (3.7); 8.1496 (3.0); 8.1481 (3.1); 8.1462 (2.8); 8.1442 (3.5); 8.1403 (3.1); 8.0510 (1.7); 8.0451 (1.6); 8.0416 (1.7); 8.0366 (1.8); 8.0347 (1.8); 8.0319 (1.6); 8.0273 (1.9); 8.0214 (1.8); 7.9901 (4.4); 7.6480 (2.0); 7.6316 (2.0); 7.6213 (0.8); 7.6180 (0.7); 7.6113 (7.8); 7.6092 (6.2); 7.6021 (3.6); 7.5988 (3.9); 7.5968 (4.2); 7.5952 (3.9); 7.4108 (3.2); 7.4073 (3.4); 7.3908 (3.5); 7.3871 (3.5); 7.2686 (1.4); 7.2649 (1.4); 7.2500 (1.9); 7.2471 (2.4); 7.2443 (1.6); 7.2294 (1.6); 7.2256 (1.5); 6.9866 (2.4); 6.9827 (2.5); 6.9682 (2.5); 6.9667 (2.4); 6.9643 (2.5); 6.9627 (2.5); 6.9482 (2.0); 6.9442 (2.0); 4.4328 (0.6); 4.4249 (0.9); 4.4162 (1.0); 4.4070 (0.9); 4.3993 (0.7); 4.2080 (1.9); 4.1919 (2.0); 4.1823 (2.4); 4.1663 (1.8); 4.0562 (1.1); 4.0384 (3.3); 4.0206 (3.4); 4.0028 (1.1); 3.7616 (1.7); 3.7533 (1.7); 3.7361 (1.6); 3.7277 (1.6); 3.4674 (4.6); 3.1187 (0.5); 3.1067 (0.6); 3.1004 (1.7); 3.0884 (1.7); 3.0822 (1.7); 3.0702 (1.8); 3.0641 (0.6); 3.0520 (0.6); 3.0376 (2.0); 3.0181 (2.2); 2.9949 (2.4); 2.9754 (2.1); 2.6706 (0.6); 2.5516 (0.6); 2.5469 (0.5); 2.5241 (1.4); 2.5194 (2.1); 2.5107 (33.0); 2.5061 (73.2); 2.5015 (103.9); 2.4969 (72.4); 2.4923 (32.0); 2.4773 (2.4); 2.4671 (2.1); 2.4608 (0.8); 2.4560 (1.0); 2.4515 (1.4); 2.4468 (1.1); 2.4345 (1.7); 2.4245 (1.7); 2.3283 (0.7); 1.9883 (16.0); 1.9090 (10.5); 1.2022 (3.2); 1.1926 (5.0); 1.1841 (7.0); 1.1748 (9.8); 1.1658 (3.2); 1.1570 (4.6); 0.0080 (1.4); 0.0038 (0.6); -0.0002 (48.0); -0.0052 (0.6); -0.0060 (0.5); -0.0085 (1.4) I.4-75: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2925 (10.6); 8.2865 (10.4); 8.1686 (1.2); 8.1208 (5.6); 8.1167 (5.6); 8.1001 (11.2); 8.0959 (11.0); 8.0795 (6.3); 8.0751 (5.6); 7.4949 (5.3); 7.4913 (6.0); 7.4755 (11.0); 7.4715 (11.5); 7.4560 (6.4); 7.4517 (6.7); 7.3772 (1.9); 7.3730 (1.6); 7.3636 (2.5); 7.3595 (3.6); 7.3564 (5.9); 7.3522 (5.9); 7.3463 (3.9); 7.3388 (16.0); 7.3331 (11.2); 7.3256 (7.8); 7.3213 (7.1); 7.3179 (3.7); 7.3111 (8.7); 7.3069 (10.9); 7.2905 (4.0); 7.2860 (3.0); 7.2724 (9.8); 7.2681 (6.1); 7.2554 (10.2); 7.2530 (8.7); 7.2500 (8.3); 7.2359 (9.0); 7.2305 (5.8); 7.2211 (10.1); 7.2092 (9.5); 7.2054 (15.3); 7.1889 (7.5); 7.1853 (7.7); 7.1801 (6.5); 7.1765 (6.8); 7.1596 (7.4); 7.1561 (7.8); 7.1062 (4.8); 7.0872 (9.6); 7.0673 (5.9); 6.9720 (4.7); 6.9677 (5.0); 6.9592 (4.9); 6.9548 (6.1); 6.9475 (4.9); 6.9404 (5.3); 6.9362 (5.3); 6.9286 (2.8); 6.9201 (2.8); 6.9157 (2.6); 5.7537 (1.3); 4.4477 (4.2); 4.4392 (4.7); 4.4303 (4.5); 4.4230 (3.0); 4.1054 (7.4); 4.0894 (7.5); 4.0807 (8.6); 4.0656 (7.5); 4.0382 (1.4); 4.0203 (1.2); 3.6048 (8.0); 3.5956 (7.8); 3.5800 (7.7); 3.5711 (7.4); 3.3767 (1.4); 3.3658 (8.7); 3.3640 (6.3); 3.3156 (1864.4); 3.2914 (3.7); 3.2830 (3.2); 3.2656 (21.3); 3.2509 (1.9); 3.2333 (3.6); 3.2251 (2.2); 3.2157 (3.2); 2.9178 (9.9); 2.8982 (10.6); 2.8753 (12.4); 2.8558 (10.9); 2.6746 (4.8); 2.6699 (6.5); 2.6654 (4.9); 2.5503 (5.7); 2.5234 (15.7); 2.5187 (22.8); 2.5100 (355.8); 2.5054 (783.2); 2.5008 (1104.3); 2.4962 (771.9); 2.4916 (341.8); 2.4559 (11.2); 2.4513 (14.2); 2.4468 (11.0); 2.4007 (2.6); 2.3727 (10.0); 2.3617 (9.8); 2.3301 (10.7); 2.3230 (6.5); 2.3189 (10.2); 2.0726 (4.7); 1.9880 (5.5); 1.9082 (6.0); 1.1923 (1.7); 1.1746 (3.2); 1.1567 (1.5); 0.0080 (5.1); -0.0002 (188.5); -0.0085 (5.6); -0.0497 (1.4) I.4-76: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.3569 (3.4); 8.2478 (1.3); 8.1606 (0.7); 8.1447 (1.3); 8.1289 (1.7); 8.1244 (2.0); 8.1080 (3.0); 8.1042 (2.8); 8.0874 (1.6); 8.0834 (1.4); 7.6953 (2.9); 7.6835 (5.6); 7.6807 (7.4); 7.6760 (4.8); 7.6616 (6.9); 7.4066 (2.3); 7.3981 (5.0); 7.3848 (3.6); 7.3795 (7.0); 7.3664 (2.4); 7.3580 (4.6); 7.2145 (1.8); 7.2108 (1.8); 7.1903 (2.7); 7.1851 (2.0); 7.1818 (2.0); 7.1611 (4.6); 7.1403 (6.5); 7.1218 (3.9); 7.1128 (3.8); 7.0924 (3.7); 7.0731 (2.0); 7.0611 (0.8); 6.9791 (1.1); 6.9748 (1.2); 6.9662 (1.4); 6.9614 (1.8); 6.9472 (1.9); 6.9272 (1.3); 5.7540 (4.4); 4.5110 (0.7); 4.1309 (1.1); 4.1172 (1.2); 4.1043 (2.3); 4.0856 (4.2); 4.0722 (4.4); 4.0645 (2.8); 4.0465 (1.3); 3.6279 (1.2); 3.6125 (1.2); 3.6016 (1.6); 3.5863 (3.0); 3.5803 (2.8); 3.5546 (0.8); 3.3650 (4.2); 3.3159 (320.3); 3.2651 (4.2); 3.2154 (0.9); 3.1133 (0.9); 3.1011 (1.0); 3.0953 (0.9); 3.0832 (0.9); 2.9755 (1.0); 2.9579 (1.4); 2.9397 (1.0); 2.6743 (1.4); 2.6700 (1.8); 2.6653 (1.4); 2.6302 (0.8); 2.6122 (1.8); 2.5930 (2.7); 2.5746 (2.4); 2.5554 (3.0); 2.5509 (3.9); 2.5462 (3.8); 2.5231 (8.7); 2.5098 (106.4); 2.5054 (213.7); 2.5008 (286.1); 2.4963 (202.7); 2.4918 (93.6); 2.4551 (3.1); 2.4507 (4.2); 2.4462 (3.4); 2.4009 (0.8); 2.3324 (1.4); 2.3275 (1.7); 2.3232 (1.2); 1.2217 (16.0); 1.2039 (15.8); 1.1952 (2.7); 1.1769 (4.0); 1.1587 (1.9); 1.1121 (6.1); 1.0938 (6.0); 0.0501 (0.6); 0.0079 (4.0); - 0.0002 (100.1); -0.0085 (4.0); -0.0501 (1.2) I.4-77: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1545 (2.8); 8.1509 (2.8); 8.1336 (3.0); 8.1300 (2.8); 7.9750 (4.7); 7.4699 (2.0); 7.4535 (2.0); 7.4090 (2.9); 7.4055 (3.0); 7.3890 (3.1); 7.3855 (3.1); 7.2610 (1.5); 7.2575 (1.4); 7.2398 (2.7); 7.2218 (1.6); 7.2184 (1.4); 6.9795 (1.8); 6.9758 (1.8); 6.9603 (2.6); 6.9568 (2.6); 6.9411 (1.5); 6.9374 (1.4); 4.3754 (1.2); 4.3559 (1.7); 4.3359 (1.1); 4.2484 (1.2); 4.2404 (1.3); 4.2315 (1.2); 3.6412 (2.7); 3.6250 (3.0); 3.6159 (3.4); 3.5997 (3.2); 3.5124 (4.0); 3.1408 (2.2); 3.1323 (2.2); 3.1154 (2.1); 3.1069 (2.2); 3.1006 (1.0); 3.0883 (0.9); 3.0821 (0.9); 3.0697 (0.8); 2.6850 (2.0); 2.6653 (2.5); 2.6432 (2.4); 2.6234 (2.2); 2.5517 (1.0); 2.5102 (33.8); 2.5059 (68.0); 2.5015 (91.7); 2.4970 (67.7); 2.4930 (33.9); 2.4519 (1.7); 2.3284 (0.6); 2.1329 (2.2); 2.1226 (2.3); 2.0911 (2.0); 2.0809 (2.0); 1.9882 (1.1); 1.9087 (16.0); 1.7200 (1.4); 1.6930 (1.6); 1.6719 (1.4); 1.6424 (2.5); 1.6289 (1.7); 1.5292 (3.3); 1.5131 (4.1); 1.2022 (1.4); 1.1840 (2.9); 1.1747 (0.8); 1.1658 (1.4); -0.0002 (10.7) I.4-78: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2465 (0.7); 8.2403 (0.7); 8.1511 (0.6); 8.1487 (1.1); 8.1457 (1.1); 8.1437 (0.9); 8.1422 (0.9); 8.1405 (0.7); 8.0922 (0.8); 8.0881 (0.8); 8.0421 (0.5); 8.0329 (0.5); 8.0275 (0.6); 8.0260 (0.6); 8.0184 (0.6); 8.0125 (0.5); 7.6082 (2.4); 7.6060 (2.0); 7.5992 (1.1); 7.5959 (1.2); 7.5936 (1.2); 7.5921 (1.2); 7.2279 (0.7); 7.2111 (0.7); 7.1773 (0.5); 7.1482 (0.6); 7.0876 (0.6); 4.1998 (0.6); 4.1834 (0.6); 4.1743 (0.7); 4.1580 (0.6); 3.7542 (0.5); 3.7450 (0.5); 3.3200 (14.1); 3.0193 (0.6); 2.9996 (0.7); 2.9766 (0.8); 2.9570 (0.7); 2.5119 (3.3); 2.5074 (7.2); 2.5027 (10.1); 2.4981 (7.0); 2.4935 (3.1); 2.4861 (0.7); 2.4750 (0.6); 2.4433 (0.5); 2.0743 (16.0); 1.1829 (1.0); -0.0002 (6.2) I.4-79: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1588 (4.0); 8.1549 (4.0); 8.1379 (4.3); 8.1340 (4.0); 7.9766 (6.2); 7.9149 (6.8); 7.9093 (2.5); 7.8977 (3.6); 7.8920 (16.0); 7.8871 (2.5); 7.8661 (2.9); 7.8613 (15.7); 7.8556 (3.1); 7.8439 (2.4); 7.8384 (6.4); 7.7740 (0.6); 7.6311 (2.8); 7.6142 (2.8); 7.4089 (4.5); 7.4054 (4.8); 7.3889 (5.2); 7.3852 (4.8); 7.2665 (2.1); 7.2632 (1.9); 7.2452 (3.4); 7.2274 (2.4); 7.2237 (2.2); 6.9859 (3.2); 6.9819 (3.3); 6.9674 (3.6); 6.9660 (3.5); 6.9636 (3.4); 6.9620 (3.5); 6.9474 (2.8); 6.9435 (2.6); 4.4245 (1.3); 4.4155 (1.6); 4.4090 (1.4); 4.2145 (2.5); 4.1985 (2.6); 4.1888 (3.2); 4.1729 (2.5); 4.0382 (0.6); 4.0202 (0.7); 3.7600 (2.2); 3.7517 (2.2); 3.7346 (2.1); 3.7261 (2.1); 3.3682 (3.0); 3.3517 (2.0); 3.3196 (489.3); 3.2819 (1.1); 3.2697 (5.3); 3.2375 (0.9); 3.2189 (0.8); 3.1288 (1.0); 3.1164 (1.1); 3.1103 (3.4); 3.0983 (3.4); 3.0920 (3.4); 3.0801 (3.3); 3.0745 (1.1); 3.0619 (1.1); 3.0537 (2.7); 3.0344 (2.9); 3.0109 (3.3); 2.9915 (2.9); 2.6744 (2.2); 2.6698 (3.0); 2.6651 (2.1); 2.5511 (3.1); 2.5462 (3.1); 2.5233 (8.8); 2.5186 (12.3); 2.5099 (163.7); 2.5053 (357.2); 2.5007 (503.5); 2.4961 (351.7); 2.4915 (157.0); 2.4600 (3.1); 2.4556 (5.1); 2.4510 (8.7); 2.4464 (5.7); 2.4414 (4.6); 2.4012 (1.2); 2.3321 (2.3); 2.3275 (3.1); 2.3228 (2.3); 2.0727 (3.8); 1.9879 (3.3); 1.9082 (1.7); 1.1968 (6.3); 1.1923 (1.5); 1.1786 (13.2); 1.1746 (2.9); 1.1604 (6.2); 0.1458 (0.6); 0.0499 (0.5); 0.0080 (6.4); 0.0055 (1.8); -0.0002 (227.1); -0.0085 (7.0); -0.0499 (2.5); -0.1499 (0.8) I.4-80: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1794 (0.5); 8.1723 (1.8); 8.1684 (1.9); 8.1514 (2.0); 8.1476 (1.9); 8.0939 (2.9); 8.0433 (0.6); 7.7165 (0.6); 7.7137 (0.8); 7.6943 (1.1); 7.6917 (1.3); 7.6884 (2.9); 7.6855 (3.6); 7.6804 (0.9); 7.6687 (1.9); 7.6663 (3.9); 7.6638 (3.3); 7.5425 (1.2); 7.5259 (1.3); 7.4237 (2.1); 7.4201 (2.2); 7.4102 (0.8); 7.4036 (2.8); 7.4003 (5.1); 7.3956 (1.4); 7.3918 (1.0); 7.3879 (1.0); 7.3821 (3.6); 7.3793 (3.3); 7.3701 (0.8); 7.3652 (1.0); 7.3605 (2.8); 7.2739 (1.0); 7.2701 (1.0); 7.2553 (1.3); 7.2524 (1.6); 7.2347 (1.1); 7.2310 (1.0); 7.1632 (1.0); 7.1605 (1.8); 7.1578 (1.1); 7.1421 (2.8); 7.1264 (0.8); 7.1236 (1.3); 7.1209 (0.7); 6.9957 (1.5); 6.9917 (1.6); 6.9772 (1.6); 6.9758 (1.6); 6.9733 (1.6); 6.9718 (1.8); 6.9573 (1.3); 6.9533 (1.5); 4.1237 (1.1); 4.1052 (1.9); 4.0886 (1.3); 4.0831 (1.6); 4.0787 (1.0); 4.0587 (1.0); 4.0412 (0.7); 3.6078 (1.2); 3.5922 (1.5); 3.5855 (1.4); 3.5699 (0.8); 3.3536 (13.4); 3.1092 (0.6); 3.0972 (0.5); 3.0909 (0.6); 3.0789 (0.6); 2.6701 (0.5); 2.6096 (1.1); 2.5916 (1.4); 2.5718 (1.0); 2.5520 (0.6); 2.5236 (1.2); 2.5189 (1.8); 2.5102 (26.2); 2.5056 (57.2); 2.5010 (80.1); 2.4964 (55.8); 2.4918 (24.7); 2.4557 (0.8); 2.4512 (1.1); 2.4466 (0.8); 1.9881 (0.9); 1.9086 (16.0); 1.2325 (9.3); 1.2146 (9.0); 1.1968 (1.1); 1.1786 (2.2); 1.1746 (0.7); 1.1604 (1.0); 1.1192 (1.8); 1.1009 (1.8); -0.0002 (15.7) I.4-81: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5863 (1.4); 8.4650 (0.6); 8.0326 (1.1); 8.0245 (1.2); 8.0165 (0.9); 8.0084 (0.9); 8.0042 (1.2); 7.9961 (1.0); 7.9880 (0.8); 7.9800 (0.7); 7.6946 (1.3); 7.6918 (1.6); 7.6828 (3.0); 7.6799 (3.8); 7.6749 (1.8); 7.6727 (1.9); 7.6700 (1.6); 7.6608 (4.1); 7.6582 (3.3); 7.4069 (1.3); 7.3993 (3.0); 7.3941 (1.2); 7.3883 (1.8); 7.3856 (1.8); 7.3808 (3.8); 7.3779 (2.9); 7.3718 (0.7); 7.3666 (1.4); 7.3639 (1.1); 7.3591 (2.8); 7.2746 (0.8); 7.2616 (0.9); 7.2522 (1.1); 7.2471 (1.0); 7.2391 (1.1); 7.2340 (1.0); 7.2244 (1.4); 7.2122 (1.9); 7.1989 (1.8); 7.1629 (1.2); 7.1602 (2.0); 7.1575 (1.1); 7.1417 (3.3); 7.1259 (0.9); 7.1232 (1.4); 6.7894 (0.5); 6.7806 (0.8); 6.7697 (0.7); 6.7664 (0.7); 6.7604 (1.1); 6.7470 (0.7); 6.7380 (1.0); 4.1333 (0.6); 4.1199 (0.6); 4.1078 (1.0); 4.0904 (2.5); 4.0776 (2.1); 4.0707 (1.4); 4.0559 (0.7); 4.0382 (0.9); 4.0204 (0.9); 3.6386 (0.6); 3.6335 (0.6); 3.6164 (0.7); 3.6125 (0.7); 3.6073 (0.7); 3.5904 (1.6); 3.5843 (1.6); 3.3252 (43.8); 3.2422 (0.8); 2.9866 (0.6); 2.9688 (0.8); 2.9512 (0.6); 2.6746 (0.7); 2.6699 (1.0); 2.6653 (0.7); 2.6171 (0.9); 2.5975 (1.2); 2.5791 (0.9); 2.5233 (2.6); 2.5186 (4.0); 2.5100 (53.9); 2.5054 (116.1); 2.5008 (160.7); 2.4961 (111.9); 2.4915 (49.6); 2.4553 (0.8); 2.4507 (1.0); 2.4459 (0.7); 2.3322 (0.7); 2.3275 (1.0); 2.3229 (0.7); 2.0727 (0.6); 1.9880 (4.0); 1.9083 (16.0); 1.2210 (9.4); 1.2032 (9.2); 1.1924 (1.3); 1.1746 (2.3); 1.1568 (1.1); 1.1081 (3.5); 1.0898 (3.4); -0.0002 (10.2) I.4-82: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4655 (1.6); 8.3876 (1.3); 7.8586 (1.8); 7.8535 (3.4); 7.8484 (1.8); 7.5226 (12.2); 7.5092 (1.9); 7.5024 (16.0); 7.4575 (2.0); 7.4375 (3.0); 7.4170 (1.5); 7.3212 (3.9); 7.3010 (4.3); 7.2807 (2.7); 7.2570 (1.2); 7.2547 (1.4); 7.2520 (1.3); 7.2495 (1.3); 7.2373 (1.1); 7.2349 (1.1); 7.2322 (1.1); 7.2298 (1.0); 5.3101 (5.7); 4.2554 (1.0); 4.2380 (1.3); 4.2273 (1.2); 4.2101 (1.3); 4.0629 (0.5); 4.0442 (0.8); 3.8252 (1.1); 3.8197 (1.0); 3.7971 (1.0); 3.7914 (1.0); 3.3950 (1.5); 3.3767 (5.0); 3.3586 (5.3); 3.3405 (2.1); 3.3148 (180.7); 3.2644 (0.7); 3.0969 (0.8); 3.0780 (3.0); 3.0603 (2.6); 3.0423 (0.8); 3.0325 (1.4); 3.0120 (1.3); 2.6698 (0.5); 2.6072 (1.1); 2.6000 (1.1); 2.5625 (0.9); 2.5557 (1.0); 2.5233 (1.7); 2.5186 (2.3); 2.5100 (34.2); 2.5054 (74.2); 2.5008 (104.1); 2.4962 (73.6); 2.4916 (33.7); 2.3276 (0.6); 1.2509 (4.2); 1.2328 (9.0); 1.2146 (4.3); 1.2091 (3.9); 1.1908 (7.4); 1.1726 (3.4) I.4-83: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0365 (2.6); 8.0309 (2.6); 7.7443 (2.4); 7.1955 (1.0); 7.1793 (1.0); 7.1444 (1.7); 7.1430 (1.6); 7.1242 (2.0); 7.1227 (2.0); 6.9131 (1.7); 6.9075 (1.7); 6.8932 (1.5); 6.8873 (1.4); 4.2384 (0.6); 4.2293 (0.5); 3.6544 (1.4); 3.6382 (1.6); 3.6289 (1.7); 3.6126 (1.5); 3.4839 (2.2); 3.1887 (1.2); 3.1797 (1.2); 3.1631 (1.2); 3.1543 (1.1); 3.0119 (2.7); 2.9936 (2.9); 2.7097 (1.0); 2.6898 (1.1); 2.6681 (1.4); 2.6481 (1.1); 2.5235 (1.0); 2.5188 (1.5); 2.5101 (24.6); 2.5055 (54.4); 2.5009 (77.1); 2.4962 (53.7); 2.4916 (23.7); 2.4510 (0.6); 2.1581 (1.2); 2.1427 (11.8); 2.1165 (1.0); 2.1057 (1.0); 1.9879 (0.6); 1.9083 (16.0); 1.8717 (0.7); 1.8549 (0.9); 1.8381 (0.7); 1.1992 (0.5); 1.1810 (1.1); 1.1628 (0.5); 0.8500 (8.4); 0.8340 (13.0); 0.8181 (8.2); 0.0081 (1.5); 0.0040 (0.6); 0.0024 (1.9); -0.0002 (56.1); -0.0050 (0.8); -0.0058 (0.7); -0.0066 (0.6); -0.0085 (1.6) I.4-84: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4504 (2.0); 8.0164 (1.2); 8.0083 (1.2); 8.0001 (1.2); 7.9921 (1.2); 7.9880 (1.2); 7.9801 (1.0); 7.9716 (1.2); 7.9637 (1.0); 7.2598 (1.3); 7.2468 (1.3); 7.2372 (1.4); 7.2322 (1.4); 7.2242 (1.4); 7.2192 (1.4); 7.2095 (1.3); 7.1966 (1.2); 7.1501 (1.9); 7.1331 (1.8); 6.7718 (0.8); 6.7630 (1.2); 6.7544 (0.9); 6.7519 (1.0); 6.7492 (0.8); 6.7428 (1.5); 6.7346 (0.9); 6.7293 (0.7); 6.7206 (1.0); 6.7121 (0.6); 4.3677 (1.0); 4.3488 (1.5); 4.3282 (0.9); 4.2592 (0.7); 4.2513 (1.0); 4.2427 (1.1); 4.2335 (0.9); 4.2259 (0.7); 3.6398 (2.1); 3.6234 (2.3); 3.6142 (2.6); 3.5981 (2.3); 3.4492 (10.8); 3.1318 (2.0); 3.1233 (2.3); 3.1058 (3.4); 3.0976 (2.0); 3.0936 (2.0); 3.0873 (1.9); 3.0754 (1.8); 3.0692 (0.6); 3.0571 (0.5); 2.6752 (2.9); 2.6699 (1.6); 2.6652 (1.0); 2.6558 (2.4); 2.6338 (2.8); 2.6141 (2.6); 2.5233 (3.4); 2.5187 (5.3); 2.5100 (80.0); 2.5054 (174.8); 2.5008 (243.6); 2.4961 (169.2); 2.4915 (74.7); 2.4555 (1.1); 2.4509 (1.4); 2.4462 (1.0); 2.3322 (1.0); 2.3276 (1.5); 2.3230 (1.0); 2.1319 (2.1); 2.1213 (2.1); 2.0901 (1.9); 2.0796 (1.9); 2.0727 (0.6); 1.9081 (16.0); 1.7032 (1.1); 1.6874 (1.3); 1.6546 (1.6); 1.6418 (1.8); 1.5291 (2.3); 1.5183 (2.6); 1.5121 (2.8); 1.4884 (1.5); 1.4695 (0.9); 1.1994 (3.5); 1.1812 (7.5); 1.1629 (3.5); -0.0002 (14.5) I.4-85: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2277 (2.5); 8.2219 (2.4); 8.1207 (1.4); 8.1165 (1.5); 8.1000 (2.8); 8.0958 (2.8); 8.0792 (1.6); 8.0750 (1.5); 7.1997 (1.6); 7.1961 (1.7); 7.1793 (1.9); 7.1757 (2.0); 7.1704 (1.6); 7.1668 (1.8); 7.1500 (1.9); 7.1465 (2.1); 7.1009 (1.2); 7.0793 (2.6); 7.0701 (1.9); 7.0623 (2.1); 7.0531 (1.9); 6.9628 (1.2); 6.9585 (1.3); 6.9500 (1.3); 6.9456 (1.6); 6.9442 (1.5); 6.9425 (1.3); 6.9382 (1.3); 6.9312 (1.4); 6.9270 (1.3); 6.9254 (1.3); 6.9195 (0.8); 6.9110 (0.8); 6.9067 (0.8); 4.5204 (1.0); 4.5004 (1.8); 4.4799 (1.0); 4.2656 (0.7); 4.2581 (1.0); 4.2489 (1.1); 4.2397 (1.0); 4.2319 (0.7); 4.0381 (0.7); 4.0203 (0.7); 3.7354 (2.6); 3.7189 (2.8); 3.7101 (3.2); 3.6936 (2.8); 3.5543 (3.9); 3.2685 (2.4); 3.2591 (2.4); 3.2431 (2.2); 3.2340 (2.1); 3.1184 (0.8); 3.1061 (0.8); 3.1001 (2.7); 3.0881 (2.7); 3.0819 (2.8); 3.0699 (2.7); 3.0636 (0.9); 3.0517 (0.9); 2.6757 (3.1); 2.6699 (1.2); 2.6652 (0.8); 2.6559 (3.0); 2.6339 (3.5); 2.6141 (3.0); 2.5234 (2.3); 2.5187 (3.5); 2.5100 (55.2); 2.5054 (122.4); 2.5008 (172.0); 2.4961 (118.7); 2.4915 (52.0); 2.4563 (0.8); 2.4517 (0.8); 2.3323 (0.7); 2.3275 (1.0); 2.3229 (0.7); 2.1958 (1.0); 2.1895 (1.2); 2.1807 (0.8); 2.1710 (2.0); 2.1650 (1.7); 2.1568 (1.0); 2.1462 (4.2); 2.1349 (3.1); 2.1222 (0.6); 2.1124 (0.6); 2.1040 (2.2); 2.0929 (2.2); 2.0727 (0.7); 2.0329 (0.5); 2.0156 (1.4); 2.0100 (1.1); 1.9996 (1.8); 1.9945 (1.5); 1.9878 (4.6); 1.9804 (1.4); 1.9716 (1.2); 1.9082 (16.0); 1.6679 (0.7); 1.6521 (2.0); 1.6431 (1.5); 1.6387 (1.9); 1.6276 (3.5); 1.6143 (2.0); 1.6030 (1.6); 1.5879 (0.6); 1.2019 (5.3); 1.1923 (1.2); 1.1837 (11.2); 1.1746 (2.3); 1.1654 (5.1); 1.1567 (1.1); 0.0079 (3.3); 0.0063 (0.9); 0.0055 (1.0); 0.0047 (1.2); 0.0038 (1.6); 0.0022 (4.6); -0.0002 (123.2); -0.0027 (5.5); -0.0044 (2.1); -0.0052 (1.5); -0.0060 (1.3); -0.0068 (1.1); -0.0085 (3.6); -0.0108 (0.6); -0.0116 (0.6) I.4-86: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4560 (1.8); 8.0198 (1.2); 8.0116 (1.2); 8.0033 (1.2); 7.9953 (1.2); 7.9913 (1.2); 7.9831 (1.1); 7.9749 (1.1); 7.9668 (1.0); 7.2604 (1.2); 7.2473 (1.3); 7.2377 (1.4); 7.2328 (1.3); 7.2247 (1.3); 7.2196 (1.3); 7.2101 (1.3); 7.1970 (1.2); 7.1475 (1.8); 7.1308 (1.7); 6.7720 (0.8); 6.7632 (1.2); 6.7547 (0.9); 6.7522 (0.9); 6.7495 (0.8); 6.7430 (1.4); 6.7348 (0.9); 6.7297 (0.8); 6.7208 (1.0); 6.7122 (0.5); 4.2610 (0.7); 4.2528 (1.0); 4.2436 (1.1); 4.2356 (0.9); 4.2269 (0.7); 4.2056 (0.7); 4.1886 (1.7); 4.1716 (2.3); 4.1546 (1.7); 4.1379 (0.6); 3.6049 (2.4); 3.5885 (2.6); 3.5794 (2.9); 3.5631 (2.6); 3.4651 (8.7); 3.1229 (0.6); 3.1117 (2.4); 3.1042 (3.2); 3.0926 (2.0); 3.0864 (3.8); 3.0776 (2.0); 3.0744 (2.2); 3.0682 (0.7); 3.0562 (0.6); 2.6746 (1.0); 2.6675 (2.7); 2.6478 (2.4); 2.6258 (2.8); 2.6061 (2.4); 2.5234 (2.7); 2.5187 (3.9); 2.5100 (72.7); 2.5054 (162.8); 2.5008 (230.4); 2.4962 (161.8); 2.4916 (72.4); 2.4557 (1.6); 2.4510 (1.9); 2.4464 (1.4); 2.4178 (0.6); 2.3323 (1.0); 2.3276 (1.5); 2.3229 (1.1); 2.1265 (2.2); 2.1158 (2.2); 2.0849 (1.9); 2.0738 (1.9); 1.9082 (16.0); 1.1998 (3.6); 1.1816 (7.6); 1.1633 (3.5); 1.0859 (13.4); 1.0689 (14.2); 1.0650 (14.6); 1.0480 (13.5); -0.0002 (15.6) I.4-87: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8227 (1.7); 7.8025 (2.0); 7.6052 (2.6); 7.1238 (1.5); 7.1054 (2.4); 7.0862 (1.6); 7.0670 (0.9); 7.0028 (1.0); 6.9861 (0.9); 6.8941 (1.2); 6.8911 (1.2); 6.8756 (2.0); 6.8727 (2.0); 6.8572 (0.9); 6.8541 (0.8); 4.5295 (0.6); 4.5054 (1.1); 4.4818 (0.6); 4.2432 (0.7); 4.0380 (0.5); 4.0202 (0.5); 3.7326 (1.6); 3.7161 (1.7); 3.7074 (1.9); 3.6909 (1.6); 3.5247 (3.0); 3.2714 (1.5); 3.2621 (1.5); 3.2462 (1.4); 3.2370 (1.4); 3.1217 (0.5); 3.1096 (0.6); 3.1034 (1.8); 3.0914 (1.9); 3.0852 (1.9); 3.0731 (1.9); 3.0670 (0.6); 3.0549 (0.6); 2.6755 (2.0); 2.6694 (1.0); 2.6647 (0.7); 2.6556 (1.9); 2.6337 (2.2); 2.6137 (1.9); 2.5230 (2.3); 2.5182 (3.4); 2.5096 (49.4); 2.5050 (108.6); 2.5003 (152.4); 2.4957 (105.1); 2.4911 (46.1); 2.4594 (0.5); 2.4547 (1.0); 2.4501 (1.4); 2.4455 (1.0); 2.3318 (0.7); 2.3271 (0.9); 2.3224 (0.8); 2.2665 (2.1); 2.1964 (0.8); 2.1915 (0.8); 2.1648 (16.0); 2.1535 (2.2); 2.1477 (1.6); 2.1425 (2.5); 2.1117 (1.6); 2.1005 (1.5); 2.0174 (0.8); 2.0010 (1.2); 1.9960 (1.0); 1.9877 (3.4); 1.9727 (0.8); 1.9079 (7.6); 1.6534 (1.3); 1.6403 (1.2); 1.6290 (2.3); 1.6159 (1.2); 1.6045 (1.0); 1.1998 (3.6); 1.1922 (0.9); 1.1816 (7.6); 1.1744 (1.7); 1.1633 (3.5); 1.1566 (0.8); 1.1047 (0.7); 0.0080 (2.7); -0.0002 (103.8); -0.0086 (2.9); -0.0504 (0.8) I.4-88: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.3388 (0.6); 8.4265 (4.7); 8.0060 (2.6); 7.9981 (2.4); 7.9897 (2.5); 7.9816 (2.7); 7.9698 (2.3); 7.9612 (2.2); 7.9535 (1.8); 7.2577 (2.3); 7.2446 (2.6); 7.2352 (2.8); 7.2299 (2.6); 7.2224 (2.8); 7.2173 (2.5); 7.2076 (2.4); 7.1946 (2.3); 7.1317 (4.5); 7.1150 (4.1); 6.7699 (1.6); 6.7614 (2.5); 6.7506 (2.2); 6.7409 (3.4); 6.7325 (1.8); 6.7188 (2.1); 6.7101 (0.9); 4.2132 (2.4); 4.2039 (2.4); 4.1955 (2.3); 3.5808 (4.4); 3.5641 (4.5); 3.5557 (5.1); 3.5391 (4.4); 3.3110 (75.4); 3.0629 (4.5); 3.0538 (4.2); 3.0380 (3.9); 3.0287 (3.9); 2.6704 (6.5); 2.6506 (5.9); 2.6299 (5.5); 2.6094 (4.6); 2.5563 (3.6); 2.5516 (3.7); 2.5094 (165.2); 2.5051 (313.8); 2.5007 (409.5); 2.4962 (288.6); 2.4918 (134.0); 2.3277 (2.5); 2.1286 (3.8); 2.1168 (3.8); 2.0862 (3.4); 2.0751 (3.3); 1.9881 (1.3); 1.9077 (16.0); 1.2373 (0.6); 1.1749 (0.8); 1.0474 (5.1); 0.7053 (0.7); 0.6917 (1.7); 0.6756 (3.7); 0.6633 (14.9); 0.6470 (13.1); 0.6280 (5.9); 0.6184 (2.2); 0.6032 (1.7); 0.5925 (1.1); 0.0079 (3.5); -0.0002 (77.4); -0.0084 (3.9) I.4-89: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4503 (1.4); 8.0212 (0.9); 8.0130 (0.9); 8.0048 (0.8); 7.9968 (0.8); 7.9927 (0.8); 7.9846 (0.8); 7.9764 (0.8); 7.9683 (0.7); 7.2606 (0.9); 7.2475 (0.9); 7.2378 (1.0); 7.2329 (1.0); 7.2249 (1.0); 7.2199 (0.9); 7.2103 (0.9); 7.1973 (0.9); 7.1627 (1.3); 7.1464 (1.2); 6.7742 (0.6); 6.7652 (0.8); 6.7568 (0.7); 6.7544 (0.7); 6.7516 (0.6); 6.7452 (1.0); 6.7370 (0.6); 6.7319 (0.5); 6.7227 (0.7); 4.5222 (0.6); 4.4990 (1.1); 4.4786 (0.6); 4.2621 (0.7); 4.2536 (0.8); 4.2447 (0.7); 3.7394 (1.5); 3.7228 (1.6); 3.7139 (1.8); 3.6975 (1.6); 3.4546 (5.8); 3.2719 (1.5); 3.2628 (1.5); 3.2466 (1.4); 3.2376 (1.3); 3.1058 (0.6); 3.0938 (0.7); 3.0875 (0.6); 3.0756 (0.7); 2.6838 (1.6); 2.6747 (0.6); 2.6699 (0.9); 2.6641 (2.0); 2.6419 (2.0); 2.6221 (1.7); 2.5347 (0.5); 2.5235 (1.7); 2.5188 (2.6); 2.5101 (45.4); 2.5055 (101.1); 2.5009 (142.8); 2.4963 (100.1); 2.4916 (44.6); 2.4741 (0.8); 2.4695 (0.7); 2.4601 (0.5); 2.4555 (0.8); 2.4509 (1.1); 2.4465 (0.8); 2.3323 (0.6); 2.3277 (0.9); 2.3230 (0.6); 2.1965 (0.6); 2.1894 (0.7); 2.1715 (1.2); 2.1647 (1.1); 2.1469 (2.6); 2.1361 (2.2); 2.1048 (1.4); 2.0938 (1.4); 2.0727 (0.6); 2.0153 (0.8); 2.0044 (1.0); 1.9995 (1.1); 1.9879 (1.0); 1.9802 (0.9); 1.9699 (0.7); 1.9082 (16.0); 1.6522 (1.2); 1.6388 (1.2); 1.6277 (2.2); 1.6144 (1.2); 1.6031 (1.0); 1.1993 (1.2); 1.1811 (2.6); 1.1629 (1.2); -0.0002 (8.9) I.4-90: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2307 (2.2); 8.2245 (2.2); 8.1107 (1.3); 8.1065 (1.3); 8.0900 (2.5); 8.0858 (2.4); 8.0692 (1.3); 8.0650 (1.3); 7.1987 (1.4); 7.1951 (1.5); 7.1784 (1.8); 7.1747 (1.8); 7.1694 (1.4); 7.1658 (1.5); 7.1490 (1.8); 7.1454 (1.9); 7.0982 (1.1); 7.0789 (2.3); 7.0652 (1.9); 7.0599 (1.9); 7.0490 (1.8); 6.9614 (1.2); 6.9571 (1.1); 6.9485 (1.2); 6.9441 (1.4); 6.9384 (1.1); 6.9298 (1.2); 6.9256 (1.2); 6.9180 (0.7); 6.9095 (0.7); 6.9053 (0.6); 5.7538 (0.5); 4.2644 (0.7); 4.2569 (0.9); 4.2482 (1.0); 4.2383 (0.9); 4.2316 (0.6); 3.6503 (2.4); 3.6337 (2.5); 3.6247 (2.9); 3.6082 (2.5); 3.4413 (10.6); 3.1802 (2.2); 3.1710 (2.2); 3.1547 (2.0); 3.1456 (2.0); 3.1213 (0.8); 3.1093 (0.9); 3.1030 (2.8); 3.0910 (2.8); 3.0848 (2.8); 3.0728 (2.8); 3.0666 (0.9); 3.0545 (0.8); 3.0474 (0.7); 3.0286 (0.7); 3.0143 (2.8); 2.9962 (4.9); 2.9787 (2.8); 2.9640 (0.7); 2.9454 (0.7); 2.6954 (1.7); 2.6751 (2.3); 2.6698 (1.2); 2.6651 (0.8); 2.6537 (2.1); 2.6337 (1.9); 2.5233 (2.5); 2.5185 (3.7); 2.5099 (58.2); 2.5053 (128.9); 2.5006 (181.2); 2.4960 (125.4); 2.4914 (55.4); 2.4689 (0.8); 2.4599 (0.9); 2.4553 (1.3); 2.4506 (1.6); 2.4460 (1.1); 2.4416 (0.6); 2.3321 (0.8); 2.3275 (1.1); 2.3230 (0.8); 2.1505 (2.0); 2.1396 (2.0); 2.1089 (1.7); 2.0979 (1.7); 2.0726 (1.2); 1.9879 (0.7); 1.9081 (7.4); 1.8854 (0.6); 1.8676 (1.2); 1.8509 (1.6); 1.8341 (1.3); 1.8173 (0.6); 1.2005 (5.5); 1.1822 (11.6); 1.1746 (0.7); 1.1640 (5.3); 0.8483 (14.8); 0.8354 (16.0); 0.8317 (15.8); 0.8188 (14.4); 0.0081 (3.5); 0.0057 (1.0); 0.0049 (1.2); 0.0041 (1.5); -0.0002 (127.2); -0.0057 (1.2); -0.0065 (1.0); -0.0086 (3.5); -0.0503 (1.0) I.4-91: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8069 (1.8); 7.8043 (1.8); 7.7866 (1.9); 7.7840 (1.9); 7.6131 (2.7); 7.1228 (1.6); 7.1028 (2.4); 7.0830 (1.6); 7.0637 (1.0); 7.0184 (1.0); 7.0029 (0.9); 6.8931 (1.2); 6.8900 (1.2); 6.8746 (2.0); 6.8716 (2.0); 6.8563 (0.9); 6.8529 (0.8); 4.2350 (0.7); 3.6422 (2.5); 3.6258 (3.0); 3.6168 (3.5); 3.6005 (3.9); 3.1868 (1.6); 3.1778 (1.6); 3.1615 (1.5); 3.1525 (1.5); 3.1182 (0.7); 3.1062 (0.8); 3.1000 (2.4); 3.0880 (2.4); 3.0818 (2.4); 3.0698 (2.4); 3.0636 (0.8); 3.0513 (0.9); 3.0159 (2.2); 3.0041 (2.3); 2.9971 (2.4); 2.9856 (2.2); 2.6922 (1.3); 2.6724 (1.6); 2.6650 (0.6); 2.6505 (1.5); 2.6305 (1.4); 2.5231 (2.2); 2.5183 (3.3); 2.5097 (43.9); 2.5051 (94.3); 2.5005 (130.8); 2.4959 (90.9); 2.4913 (40.2); 2.4553 (0.9); 2.4507 (1.2); 2.4461 (0.8); 2.3319 (0.6); 2.3273 (0.8); 2.3226 (0.6); 2.2676 (1.6); 2.1618 (16.0); 2.1492 (1.8); 2.1184 (1.2); 2.1072 (1.3); 1.9877 (0.7); 1.9080 (5.8); 1.8708 (0.9); 1.8539 (1.2); 1.8370 (0.9); 1.2015 (4.8); 1.1833 (10.1); 1.1745 (0.6); 1.1651 (4.7); 0.8504 (10.5); 0.8359 (12.8); 0.8340 (12.6); 0.8196 (10.1); 0.0080 (2.3); -0.0002 (80.5); -0.0086 (2.5); -0.0500 (0.8) I.4-92: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4647 (1.2); 8.0111 (0.7); 8.0029 (0.7); 7.9946 (0.7); 7.9867 (0.7); 7.9825 (0.7); 7.9745 (0.7); 7.9663 (0.7); 7.9582 (0.6); 7.2594 (0.7); 7.2464 (0.8); 7.2367 (0.8); 7.2318 (0.8); 7.2237 (0.8); 7.2187 (0.8); 7.2092 (0.8); 7.1961 (0.8); 7.1771 (1.0); 7.1603 (1.0); 6.7634 (0.8); 6.7549 (0.6); 6.7524 (0.6); 6.7498 (0.5); 6.7433 (0.9); 6.7351 (0.5); 6.7213 (0.6); 4.2621 (0.6); 4.2528 (0.6); 4.2440 (0.6); 3.6861 (0.7); 3.6563 (1.8); 3.6397 (2.1); 3.6306 (2.4); 3.6141 (2.4); 3.5499 (2.8); 3.1802 (1.3); 3.1714 (1.3); 3.1547 (1.2); 3.1457 (1.1); 3.1015 (1.0); 3.0895 (1.1); 3.0833 (1.0); 3.0713 (1.1); 3.0127 (1.7); 2.9980 (1.9); 2.9940 (2.0); 2.9796 (1.6); 2.7044 (1.0); 2.6844 (1.0); 2.6747 (0.6); 2.6700 (0.8); 2.6627 (1.3); 2.6427 (1.1); 2.5235 (2.2); 2.5188 (3.2); 2.5102 (40.0); 2.5055 (86.6); 2.5009 (120.3); 2.4963 (83.6); 2.4917 (36.8); 2.4557 (0.7); 2.4510 (0.8); 2.4464 (0.6); 2.3324 (0.5); 2.3277 (0.8); 2.3231 (0.5); 2.1517 (1.1); 2.1407 (1.1); 2.1096 (1.0); 2.0988 (1.0); 1.9082 (16.0); 1.8669 (0.7); 1.8502 (0.9); 1.8332 (0.7); 1.2015 (2.0); 1.1833 (4.3); 1.1650 (2.0); 0.8473 (8.3); 0.8345 (9.0); 0.8307 (8.9); 0.8179 (8.1); -0.0002 (7.4) I.4-93: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1641 (9.2); 8.1603 (9.7); 8.1432 (10.3); 8.1394 (9.9); 7.9649 (13.6); 7.4631 (6.6); 7.4466 (6.7); 7.4106 (10.7); 7.4069 (11.1); 7.3905 (11.8); 7.3869 (11.9); 7.2651 (4.7); 7.2614 (4.6); 7.2465 (6.2); 7.2436 (8.0); 7.2410 (5.4); 7.2259 (5.2); 7.2222 (4.8); 6.9818 (7.6); 6.9779 (8.1); 6.9634 (8.3); 6.9619 (8.3); 6.9595 (8.2); 6.9579 (8.5); 6.9434 (6.6); 6.9395 (6.4); 5.7536 (16.0); 4.5492 (1.1); 4.5262 (2.8); 4.5058 (5.3); 4.4858 (3.0); 4.4822 (2.9); 4.4618 (1.2); 4.2883 (0.7); 4.2788 (1.4); 4.2695 (2.2); 4.2618 (3.1); 4.2528 (3.7); 4.2437 (3.2); 4.2362 (2.3); 4.2269 (1.4); 4.2169 (0.8); 4.0562 (0.6); 4.0384 (2.0); 4.0206 (2.0); 4.0028 (0.6); 3.7414 (6.8); 3.7250 (7.2); 3.7160 (8.3); 3.6997 (6.9); 3.3682 (1.9); 3.3490 (0.7); 3.3185 (408.9); 3.2914 (1.4); 3.2802 (7.0); 3.2713 (7.1); 3.2547 (6.2); 3.2461 (6.1); 3.2360 (0.9); 3.2189 (0.6); 2.6957 (7.3); 2.6758 (8.6); 2.6707 (1.6); 2.6658 (1.0); 2.6538 (9.1); 2.6340 (8.0); 2.5512 (1.2); 2.5240 (3.1); 2.5193 (4.7); 2.5106 (67.1); 2.5060 (147.5); 2.5014 (208.0); 2.4968 (145.4); 2.4922 (64.7); 2.4689 (1.1); 2.4561 (1.2); 2.4515 (1.5); 2.3329 (0.9); 2.3282 (1.3); 2.3235 (0.9); 2.2290 (0.9); 2.2166 (1.1); 2.2036 (2.7); 2.1907 (3.1); 2.1762 (4.8); 2.1716 (3.3); 2.1633 (4.7); 2.1518 (4.6); 2.1433 (9.5); 2.1389 (5.2); 2.1330 (8.3); 2.1144 (1.5); 2.1015 (6.4); 2.0910 (6.4); 2.0496 (0.6); 2.0375 (1.6); 2.0243 (2.8); 2.0197 (3.9); 2.0066 (5.0); 2.0039 (4.6); 1.9989 (4.6); 1.9943 (4.6); 1.9882 (13.1); 1.9789 (3.1); 1.9745 (3.6); 1.9672 (1.8); 1.9568 (1.5); 1.9447 (0.5); 1.9088 (6.3); 1.6701 (1.9); 1.6629 (1.5); 1.6538 (5.6); 1.6451 (4.2); 1.6406 (5.4); 1.6295 (10.2); 1.6162 (5.8); 1.6050 (4.7); 1.5902 (1.7); 1.1925 (2.8); 1.1748 (5.6); 1.1570 (2.7); -0.0002 (10.5) I.4-94: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1470 (6.1); 8.1431 (6.0); 8.1261 (6.5); 8.1223 (5.9); 7.9495 (7.8); 7.4468 (4.1); 7.4303 (4.0); 7.4074 (6.8); 7.4039 (7.0); 7.3874 (7.3); 7.3838 (7.1); 7.2578 (3.1); 7.2542 (2.9); 7.2391 (4.2); 7.2363 (4.8); 7.2187 (3.4); 7.2150 (2.8); 6.9775 (4.9); 6.9736 (5.2); 6.9591 (5.4); 6.9575 (5.2); 6.9551 (5.2); 6.9536 (5.0); 6.9391 (4.3); 6.9352 (4.0); 4.2254 (1.0); 4.2159 (1.5); 4.2087 (2.1); 4.1996 (2.4); 4.1901 (2.1); 4.1829 (1.5); 4.1738 (0.9); 4.1630 (0.5); 4.0559 (0.9); 4.0382 (2.7); 4.0204 (2.7); 4.0027 (1.0); 3.5827 (5.4); 3.5663 (6.0); 3.5576 (6.7); 3.5412 (5.6); 3.3648 (2.5); 3.3152 (512.3); 3.2659 (5.7); 3.2156 (0.6); 3.0683 (4.4); 3.0593 (4.4); 3.0433 (4.2); 3.0345 (4.1); 2.6909 (1.2); 2.6801 (5.5); 2.6749 (3.5); 2.6700 (3.3); 2.6614 (8.1); 2.6506 (2.2); 2.6457 (2.1); 2.6397 (4.2); 2.6198 (3.6); 2.5465 (2.3); 2.5235 (6.8); 2.5188 (9.6); 2.5101 (131.8); 2.5055 (288.8); 2.5009 (406.7); 2.4963 (284.0); 2.4916 (126.0); 2.4558 (3.8); 2.4512 (5.2); 2.4466 (4.2); 2.4004 (0.9); 2.3324 (1.9); 2.3276 (2.5); 2.3231 (1.9); 2.3183 (1.0); 2.1439 (0.7); 2.1280 (3.7); 2.1171 (3.8); 2.0860 (3.3); 2.0753 (3.2); 1.9880 (13.1); 1.8872 (1.4); 1.1924 (3.8); 1.1745 (7.9); 1.1567 (3.7); 0.8290 (0.7); 0.7098 (0.6); 0.6965 (1.8); 0.6939 (1.8); 0.6834 (1.4); 0.6781 (3.6); 0.6756 (3.5); 0.6666 (16.0); 0.6617 (5.8); 0.6561 (3.7); 0.6520 (8.8); 0.6480 (11.5); 0.6429 (5.3); 0.6412 (5.7); 0.6375 (3.6); 0.6333 (6.3); 0.6198 (1.9); 0.6144 (1.4); 0.6096 (1.9); 0.5971 (1.1); 0.0081 (2.0); -0.0002 (72.5); -0.0086 (2.2) I.4-95: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1478 (1.9); 8.1439 (1.9); 8.1269 (2.1); 8.1231 (2.0); 7.9804 (2.6); 7.4952 (1.0); 7.4793 (1.0); 7.4085 (2.2); 7.4049 (2.2); 7.3884 (2.4); 7.3848 (2.3); 7.2608 (1.0); 7.2571 (0.9); 7.2421 (1.3); 7.2392 (1.6); 7.2365 (1.0); 7.2216 (1.0); 7.2179 (1.0); 6.9795 (1.6); 6.9755 (1.7); 6.9610 (1.7); 6.9595 (1.6); 6.9571 (1.6); 6.9555 (1.7); 6.9411 (1.4); 6.9371 (1.3); 4.2551 (0.6); 4.2461 (0.6); 4.2372 (0.6); 3.6607 (0.7); 3.6574 (1.8); 3.6411 (1.9); 3.6318 (2.2); 3.6155 (2.0); 3.5289 (1.4); 3.1897 (1.4); 3.1809 (1.4); 3.1641 (1.3); 3.1554 (1.3); 3.0976 (0.8); 3.0855 (0.8); 3.0794 (0.8); 3.0673 (0.8); 3.0167 (2.1); 3.0098 (2.1); 2.9980 (2.2); 2.9912 (2.1); 2.7123 (1.1); 2.6924 (1.2); 2.6706 (1.6); 2.6506 (1.2); 2.5242 (0.7); 2.5195 (1.0); 2.5109 (15.1); 2.5062 (33.3); 2.5016 (47.0); 2.4970 (32.7); 2.4924 (14.3); 2.4518 (0.6); 2.1515 (1.2); 2.1409 (1.2); 2.1097 (1.1); 2.0992 (1.1); 1.9882 (0.5); 1.9089 (16.0); 1.8710 (0.8); 1.8542 (1.0); 1.8374 (0.8); 1.2035 (1.5); 1.1853 (3.2); 1.1670 (1.5); 0.8504 (9.5); 0.8344 (14.2); 0.8185 (9.2); -0.0002 (10.6) I.4-96: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1578 (3.1); 8.1540 (3.1); 8.1370 (3.4); 8.1331 (3.2); 7.9652 (4.2); 7.4415 (2.1); 7.4250 (2.1); 7.4095 (3.6); 7.4060 (3.7); 7.3895 (3.9); 7.3858 (3.8); 7.2622 (1.5); 7.2585 (1.5); 7.2436 (2.0); 7.2407 (2.6); 7.2380 (1.7); 7.2230 (1.7); 7.2193 (1.5); 6.9800 (2.6); 6.9760 (2.8); 6.9615 (2.9); 6.9600 (2.7); 6.9576 (2.7); 6.9560 (2.8); 6.9416 (2.3); 6.9376 (2.2); 4.2589 (0.8); 4.2512 (1.0); 4.2423 (1.2); 4.2332 (1.0); 4.2258 (0.8); 4.2119 (0.8); 4.1949 (1.8); 4.1779 (2.6); 4.1609 (1.9); 4.1440 (0.8); 3.6055 (2.4); 3.5893 (2.6); 3.5801 (2.9); 3.5639 (2.5); 3.3721 (0.7); 3.3146 (157.1); 3.2646 (1.2); 3.1200 (2.3); 3.1113 (2.3); 3.0946 (2.1); 3.0859 (2.0); 2.6771 (2.7); 2.6700 (0.7); 2.6654 (0.5); 2.6573 (2.9); 2.6355 (3.3); 2.6157 (2.9); 2.5235 (1.7); 2.5188 (2.4); 2.5101 (32.6); 2.5055 (71.6); 2.5009 (100.6); 2.4963 (70.3); 2.4917 (31.1); 2.4557 (0.8); 2.4509 (0.9); 2.4464 (0.7); 2.3277 (0.6); 2.1269 (2.4); 2.1164 (2.4); 2.0853 (2.1); 2.0747 (2.1); 2.0405 (1.0); 1.9880 (0.6); 1.0904 (15.5); 1.0734 (15.8); 1.0669 (16.0); 1.0499 (15.3); 1.0265 (0.5); 0.8728 (0.9); 0.0080 (1.0); -0.0002 (41.1); -0.0086 (1.2) I.4-97: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.1907 (4.0); 8.1849 (3.8); 8.1064 (2.2); 8.1021 (2.3); 8.0856 (4.5); 8.0814 (4.3); 8.0648 (2.4); 8.0606 (2.2); 7.1981 (2.6); 7.1945 (2.6); 7.1777 (3.0); 7.1740 (3.1); 7.1687 (2.5); 7.1651 (2.7); 7.1483 (2.9); 7.1447 (3.1); 7.0957 (1.9); 7.0765 (3.9); 7.0567 (2.4); 7.0145 (3.5); 6.9974 (3.5); 6.9598 (2.0); 6.9555 (2.0); 6.9470 (2.1); 6.9426 (2.6); 6.9368 (2.0); 6.9283 (2.2); 6.9240 (2.2); 6.9224 (2.0); 6.9165 (1.2); 6.9080 (1.2); 6.9037 (1.1); 5.7539 (1.9); 4.2264 (0.8); 4.2206 (1.1); 4.2170 (1.2); 4.2095 (1.8); 4.2003 (2.0); 4.1911 (1.8); 4.1838 (1.2); 4.1799 (1.1); 4.1738 (0.8); 3.5764 (4.9); 3.5598 (5.2); 3.5514 (5.9); 3.5349 (5.0); 3.3642 (1.8); 3.3429 (0.7); 3.3144 (321.0); 3.2841 (0.7); 3.2811 (0.6); 3.2640 (3.0); 3.0599 (4.0); 3.0505 (4.0); 3.0349 (3.8); 3.0257 (3.7); 2.6792 (1.4); 2.6746 (1.3); 2.6697 (2.4); 2.6647 (5.9); 2.6503 (3.1); 2.6457 (4.1); 2.6391 (1.9); 2.6339 (1.7); 2.6233 (4.7); 2.6037 (3.4); 2.5507 (1.7); 2.5466 (1.6); 2.5235 (3.9); 2.5188 (5.6); 2.5101 (74.6); 2.5055 (162.6); 2.5009 (228.6); 2.4962 (159.1); 2.4916 (70.1); 2.4553 (2.1); 2.4507 (2.9); 2.4462 (2.3); 2.3323 (1.0); 2.3277 (1.5); 2.3231 (1.0); 2.1268 (3.4); 2.1155 (3.4); 2.0849 (2.9); 2.0736 (3.1); 1.9880 (0.8); 1.2359 (1.3); 0.7053 (0.5); 0.6917 (1.5); 0.6874 (1.6); 0.6754 (3.7); 0.6681 (3.9); 0.6636 (16.0); 0.6594 (7.1); 0.6505 (6.0); 0.6471 (12.7); 0.6381 (3.1); 0.6363 (3.2); 0.6325 (4.4); 0.6298 (4.3); 0.6264 (4.6); 0.6177 (1.7); 0.6111 (1.4); 0.6028 (1.6); 0.5915 (0.9); 0.0080 (3.2); -0.0002 (110.7); -0.0085 (3.3); -0.0503 (0.9) I.4-98: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2191 (2.2); 8.2131 (2.2); 8.1217 (1.3); 8.1175 (1.4); 8.1010 (2.6); 8.0968 (2.6); 8.0802 (1.4); 8.0760 (1.3); 7.2006 (1.5); 7.1970 (1.5); 7.1802 (1.7); 7.1766 (1.8); 7.1713 (1.5); 7.1677 (1.6); 7.1509 (1.7); 7.1473 (1.8); 7.0999 (1.1); 7.0799 (2.1); 7.0609 (1.3); 7.0233 (2.0); 7.0064 (2.0); 6.9614 (1.2); 6.9571 (1.3); 6.9486 (1.2); 6.9442 (1.5); 6.9428 (1.4); 6.9411 (1.2); 6.9384 (1.2); 6.9368 (1.2); 6.9299 (1.2); 6.9283 (1.1); 6.9256 (1.2); 6.9239 (1.2); 6.9181 (0.7); 6.9095 (0.7); 6.9053 (0.7); 4.2570 (0.7); 4.2491 (1.0); 4.2404 (1.2); 4.2317 (1.0); 4.2238 (0.8); 4.2076 (0.8); 4.1907 (1.9); 4.1737 (2.6); 4.1567 (1.9); 4.1398 (0.7); 3.6006 (2.4); 3.5842 (2.5); 3.5752 (2.9); 3.5588 (2.5); 3.3648 (0.7); 3.3156 (151.5); 3.2656 (1.8); 3.1097 (2.2); 3.1006 (2.2); 3.0843 (2.0); 3.0753 (2.0); 2.6701 (0.6); 2.6654 (0.5); 2.6605 (2.8); 2.6408 (2.9); 2.6189 (3.3); 2.5992 (2.9); 2.5508 (0.6); 2.5236 (1.3); 2.5189 (2.0); 2.5102 (29.8); 2.5056 (66.2); 2.5010 (93.9); 2.4964 (65.2); 2.4917 (28.7); 2.4602 (0.5); 2.4554 (0.9); 2.4508 (1.2); 2.4462 (0.9); 2.3278 (0.6); 2.1253 (2.4); 2.1144 (2.4); 2.0837 (2.1); 2.0728 (3.1); 1.0866 (15.2); 1.0696 (15.9); 1.0651 (16.0); 1.0481 (15.0); 0.0080 (0.5); -0.0002 (20.3); -0.0086 (0.5) I.4-99: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2084 (11.7); 8.1129 (5.4); 8.0922 (10.7); 8.0716 (6.1); 7.1959 (6.0); 7.1753 (7.3); 7.1665 (6.8); 7.1461 (8.0); 7.0969 (5.8); 7.0768 (11.1); 7.0574 (7.0); 7.0288 (10.0); 7.0125 (10.5); 6.9565 (4.2); 6.9419 (6.8); 6.9247 (6.0); 6.9087 (3.2); 5.7526 (1.5); 4.3694 (5.0); 4.3502 (7.2); 4.3303 (4.8); 4.2550 (3.8); 4.2463 (4.9); 4.2382 (5.8); 4.2290 (5.2); 3.6346 (8.3); 3.6181 (8.9); 3.6092 (10.3); 3.5930 (8.9); 3.4094 (1.5); 3.3604 (2.4); 3.3076 (733.5); 3.2745 (10.7); 3.2585 (12.7); 3.2479 (2.6); 3.1296 (9.2); 3.1205 (10.3); 3.1040 (10.4); 3.0955 (11.0); 2.6680 (16.5); 2.6479 (9.5); 2.6259 (11.0); 2.6062 (12.0); 2.5625 (3.8); 2.5571 (4.0); 2.5225 (16.2); 2.5046 (1164.6); 2.5001 (1638.1); 2.4956 (1234.1); 2.4913 (632.8); 2.4593 (36.5); 2.4546 (35.2); 2.4500 (32.8); 2.4454 (23.4); 2.4407 (14.8); 2.3269 (9.9); 2.1300 (9.6); 2.1191 (9.8); 2.0879 (8.5); 2.0775 (8.4); 1.7158 (6.4); 1.6871 (7.1); 1.6421 (10.5); 1.5291 (12.6); 1.5121 (16.0); 1.4890 (8.8); 1.4701 (5.4); 1.1941 (4.6); 1.1760 (9.2); 1.1584 (5.2); 0.0080 (3.6); -0.0002 (115.3); -0.0084 (6.1); -0.0504 (2.1) I.4-100: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4615 (1.4); 8.1425 (2.6); 8.1394 (2.5); 8.1359 (1.9); 8.0429 (1.2); 8.0370 (1.1); 8.0341 (1.2); 8.0276 (1.8); 8.0231 (1.1); 8.0192 (1.4); 8.0134 (1.6); 8.0069 (0.9); 7.9985 (0.8); 7.9904 (0.8); 7.9865 (0.8); 7.9784 (0.7); 7.9702 (0.8); 7.9622 (0.7); 7.6201 (0.5); 7.6096 (5.5); 7.6072 (4.8); 7.6010 (2.4); 7.5976 (2.4); 7.5945 (2.6); 7.5930 (2.5); 7.3042 (1.5); 7.2877 (1.5); 7.2617 (0.8); 7.2488 (0.9); 7.2391 (0.9); 7.2343 (0.8); 7.2259 (0.8); 7.2213 (0.8); 7.2117 (0.9); 7.1986 (0.9); 6.7825 (0.6); 6.7735 (0.8); 6.7628 (0.7); 6.7534 (1.0); 6.7452 (0.6); 6.7312 (0.7); 4.4320 (0.6); 4.4226 (0.7); 4.4135 (0.7); 4.2015 (1.3); 4.1850 (1.3); 4.1759 (1.6); 4.1596 (1.2); 3.7580 (1.2); 3.7489 (1.2); 3.7325 (1.1); 3.7234 (1.0); 3.3138 (57.1); 3.1130 (0.5); 3.1011 (0.5); 3.0949 (0.5); 3.0829 (0.5); 3.0247 (1.3); 3.0049 (1.4); 2.9819 (1.6); 2.9622 (1.4); 2.6742 (0.9); 2.6696 (1.2); 2.6649 (0.9); 2.5232 (2.1); 2.5185 (3.4); 2.5098 (64.7); 2.5052 (144.2); 2.5005 (203.5); 2.4959 (142.6); 2.4913 (63.4); 2.4721 (2.3); 2.4550 (1.0); 2.4505 (1.3); 2.4460 (1.0); 2.4409 (1.5); 2.4296 (1.2); 2.3319 (1.0); 2.3274 (1.3); 2.3228 (0.9); 1.9879 (2.1); 1.9081 (16.0); 1.1957 (1.1); 1.1924 (0.7); 1.1775 (2.3); 1.1746 (1.6); 1.1592 (1.1); 1.1568 (0.8); 0.0080 (1.7); -0.0002 (72.3); -0.0085 (2.2) I.4-101: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5243 (2.0); 8.0219 (1.2); 8.0138 (1.2); 8.0058 (1.1); 7.9975 (1.2); 7.9937 (1.2); 7.9855 (1.0); 7.9774 (1.1); 7.9692 (1.1); 7.4948 (1.1); 7.4909 (1.2); 7.4753 (2.3); 7.4713 (2.4); 7.4555 (1.4); 7.4515 (1.4); 7.3648 (0.5); 7.3606 (0.7); 7.3575 (1.2); 7.3533 (1.2); 7.3393 (3.4); 7.3328 (4.2); 7.3266 (2.1); 7.3222 (2.1); 7.3172 (2.6); 7.3119 (2.5); 7.3075 (2.4); 7.2909 (1.0); 7.2865 (0.7); 7.2728 (2.1); 7.2689 (2.1); 7.2559 (3.1); 7.2536 (2.0); 7.2507 (1.8); 7.2468 (2.2); 7.2417 (1.4); 7.2363 (2.0); 7.2336 (1.5); 7.2310 (1.5); 7.2289 (1.4); 7.2191 (1.2); 7.2060 (1.2); 6.7822 (0.7); 6.7733 (1.2); 6.7647 (0.8); 6.7623 (1.0); 6.7597 (0.8); 6.7531 (1.4); 6.7450 (0.8); 6.7399 (0.8); 6.7310 (1.0); 6.7224 (0.5); 4.4598 (0.6); 4.4529 (0.9); 4.4433 (1.0); 4.4347 (0.9); 4.4269 (0.6); 4.1121 (1.6); 4.0961 (1.6); 4.0874 (1.8); 4.0720 (1.6); 4.0383 (0.8); 4.0204 (0.7); 3.6057 (1.8); 3.5965 (1.8); 3.5812 (1.8); 3.5717 (1.8); 3.4742 (3.0); 2.9263 (2.0); 2.9068 (2.2); 2.8838 (2.5); 2.8643 (2.2); 2.6744 (0.7); 2.6698 (1.0); 2.6652 (0.8); 2.5232 (2.2); 2.5186 (3.4); 2.5099 (57.4); 2.5053 (126.8); 2.5007 (178.0); 2.4960 (125.1); 2.4914 (55.9); 2.4603 (1.1); 2.4556 (1.4); 2.4511 (1.6); 2.4464 (1.1); 2.3740 (2.0); 2.3628 (2.0); 2.3318 (2.4); 2.3275 (1.4); 2.3205 (2.0); 1.9879 (3.3); 1.9083 (16.0); 1.1974 (0.6); 1.1924 (1.0); 1.1792 (1.4); 1.1747 (2.1); 1.1609 (0.6); 1.1568 (1.0); 0.0080 (1.4); -0.0002 (53.1); -0.0085 (1.6) I.4-102: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8201 (1.9); 7.7998 (2.0); 7.6822 (3.2); 7.5008 (0.9); 7.4968 (1.0); 7.4813 (1.9); 7.4772 (2.0); 7.4618 (1.1); 7.4575 (1.2); 7.3579 (0.6); 7.3551 (1.0); 7.3508 (1.1); 7.3448 (0.7); 7.3384 (3.1); 7.3348 (2.0); 7.3329 (2.1); 7.3242 (1.4); 7.3198 (1.3); 7.3112 (1.5); 7.3069 (1.9); 7.2905 (0.7); 7.2720 (1.7); 7.2676 (1.0); 7.2658 (1.0); 7.2551 (1.8); 7.2525 (1.5); 7.2498 (1.3); 7.2456 (0.8); 7.2357 (1.4); 7.2301 (0.9); 7.1734 (1.7); 7.1571 (1.7); 7.1330 (1.6); 7.1128 (2.0); 7.0904 (1.6); 7.0712 (1.0); 6.9034 (1.3); 6.9003 (1.3); 6.8849 (2.2); 6.8818 (2.1); 6.8664 (1.0); 6.8634 (0.9); 5.7544 (1.8); 4.4375 (0.7); 4.4284 (0.8); 4.4199 (0.8); 4.4126 (0.5); 4.0998 (1.3); 4.0835 (1.3); 4.0762 (1.5); 4.0600 (1.3); 3.6126 (1.4); 3.6031 (1.4); 3.5881 (1.3); 3.5786 (1.3); 3.3220 (4.6); 3.1236 (0.8); 3.1116 (0.8); 3.1054 (2.4); 3.0934 (2.5); 3.0871 (2.5); 3.0752 (2.5); 3.0690 (0.8); 3.0570 (0.8); 2.9144 (1.7); 2.8947 (1.9); 2.8721 (2.2); 2.8523 (1.9); 2.6698 (0.6); 2.5233 (1.4); 2.5186 (2.0); 2.5099 (32.6); 2.5053 (72.1); 2.5006 (101.1); 2.4960 (70.5); 2.4914 (31.2); 2.4552 (0.8); 2.4506 (1.0); 2.4460 (0.7); 2.3845 (1.6); 2.3731 (1.6); 2.3420 (1.5); 2.3309 (1.7); 2.3229 (0.6); 2.1822 (16.0); 1.9083 (5.5); 1.1987 (5.4); 1.1805 (11.4); 1.1622 (5.2); 0.0080 (1.5); 0.0048 (0.6); 0.0039 (0.8); -0.0002 (50.9); -0.0050 (0.7); -0.0059 (0.6); -0.0085 (1.4) I.4-103: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8273 (1.9); 7.8249 (1.9); 7.8069 (2.1); 7.7411 (0.6); 7.7331 (6.3); 7.7276 (1.8); 7.7159 (2.0); 7.7104 (7.5); 7.7024 (0.7); 7.6111 (3.4); 7.4556 (0.8); 7.4476 (7.7); 7.4420 (2.0); 7.4303 (1.9); 7.4249 (6.6); 7.4168 (0.6); 7.1415 (1.8); 7.1247 (3.2); 7.1049 (2.6); 7.0880 (1.7); 7.0685 (1.0); 6.8978 (1.3); 6.8949 (1.3); 6.8793 (2.1); 6.8763 (2.1); 6.8608 (1.0); 6.8578 (0.9); 4.4030 (0.5); 4.3956 (0.8); 4.3865 (0.9); 4.3779 (0.8); 4.3699 (0.6); 4.1608 (1.5); 4.1447 (1.6); 4.1355 (1.9); 4.1194 (1.5); 3.6857 (1.4); 3.6772 (1.4); 3.6604 (1.3); 3.6521 (1.2); 3.3170 (62.7); 3.2672 (0.5); 2.9877 (1.5); 2.9682 (1.7); 2.9452 (1.9); 2.9257 (1.7); 2.5233 (0.8); 2.5186 (1.2); 2.5099 (22.9); 2.5054 (50.2); 2.5007 (70.2); 2.4961 (49.5); 2.4916 (22.4); 2.4554 (0.6); 2.4508 (0.8); 2.4460 (1.9); 2.4355 (1.5); 2.4032 (1.3); 2.3930 (1.3); 2.1594 (16.0); 1.1956 (0.7); 1.1775 (1.5); 1.1591 (0.7); 0.0080 (0.7); -0.0002 (26.6); -0.0085 (0.8) I.4-104: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0595 (3.6); 8.0537 (3.6); 7.7377 (3.5); 7.7185 (3.4); 7.7126 (1.1); 7.7062 (3.6); 7.7007 (1.8); 7.6952 (3.8); 7.6888 (1.1); 7.6829 (3.5); 7.3152 (1.8); 7.2990 (1.8); 7.2463 (4.0); 7.2404 (1.0); 7.2289 (1.2); 7.2246 (5.1); 7.2190 (1.1); 7.2074 (1.0); 7.2016 (3.5); 7.1449 (2.3); 7.1434 (2.2); 7.1246 (2.7); 7.1231 (2.7); 6.9170 (2.4); 6.9114 (2.3); 6.8969 (2.0); 6.8913 (2.0); 4.4009 (0.5); 4.3930 (0.7); 4.3843 (0.8); 4.3756 (0.8); 4.3682 (0.6); 4.1717 (1.7); 4.1557 (1.7); 4.1463 (2.1); 4.1304 (1.6); 3.6867 (1.4); 3.6783 (1.4); 3.6613 (1.3); 3.6530 (1.2); 3.3134 (195.8); 3.2634 (1.2); 2.9871 (1.6); 2.9677 (1.7); 2.9447 (2.0); 2.9253 (1.8); 2.6745 (0.6); 2.6698 (0.9); 2.6651 (0.6); 2.5233 (1.7); 2.5186 (2.6); 2.5099 (47.1); 2.5053 (104.7); 2.5007 (147.1); 2.4961 (102.6); 2.4915 (45.4); 2.4553 (1.0); 2.4508 (1.2); 2.4461 (0.9); 2.4278 (1.6); 2.4178 (1.6); 2.3855 (1.3); 2.3755 (1.3); 2.3321 (0.7); 2.3275 (0.9); 2.3228 (0.6); 2.1405 (16.0); 0.0080 (1.1); -0.0002 (39.8); -0.0085 (1.1) I.4-105: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0479 (3.6); 8.0422 (3.5); 7.8026 (3.5); 7.5001 (0.9); 7.4966 (1.0); 7.4811 (1.9); 7.4770 (1.9); 7.4614 (1.1); 7.4572 (1.2); 7.3570 (1.0); 7.3528 (1.0); 7.3468 (0.8); 7.3402 (3.3); 7.3345 (3.6); 7.3262 (1.7); 7.3218 (1.8); 7.3183 (2.2); 7.3131 (1.9); 7.3086 (2.0); 7.2922 (0.7); 7.2738 (1.7); 7.2693 (0.9); 7.2568 (1.7); 7.2541 (1.4); 7.2375 (1.3); 7.2320 (0.8); 7.1552 (2.4); 7.1348 (2.7); 7.1334 (2.7); 6.9239 (2.3); 6.9182 (2.3); 6.9037 (2.0); 6.8981 (1.9); 4.4467 (0.5); 4.4398 (0.8); 4.4306 (0.8); 4.4216 (0.8); 4.4145 (0.6); 4.1148 (1.2); 4.0989 (1.3); 4.0903 (1.5); 4.0742 (1.2); 3.6149 (1.4); 3.6055 (1.4); 3.5902 (1.3); 3.5811 (1.2); 3.3201 (234.8); 3.2700 (1.1); 2.9326 (1.6); 2.9129 (1.8); 2.8901 (2.1); 2.8705 (1.8); 2.6747 (0.6); 2.6700 (0.8); 2.6654 (0.6); 2.5235 (1.8); 2.5188 (2.7); 2.5101 (42.9); 2.5055 (94.2); 2.5009 (131.9); 2.4963 (91.6); 2.4917 (40.1); 2.4557 (0.7); 2.4512 (0.8); 2.4467 (0.5); 2.3829 (1.6); 2.3719 (1.6); 2.3405 (1.4); 2.3292 (1.7); 2.3231 (0.7); 2.1625 (16.0); 2.0726 (1.6); 1.1772 (0.8); 0.0080 (1.0); -0.0002 (42.0); -0.0085 (1.2) I.4-106: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4555 (1.5); 8.0082 (0.8); 7.9998 (0.8); 7.9916 (0.8); 7.9836 (0.9); 7.9797 (0.9); 7.9715 (0.8); 7.9636 (0.8); 7.9553 (0.8); 7.9054 (2.8); 7.8997 (1.1); 7.8883 (1.9); 7.8825 (7.8); 7.8780 (1.5); 7.8629 (1.5); 7.8585 (8.0); 7.8526 (1.6); 7.8412 (1.0); 7.8356 (2.8); 7.3073 (1.5); 7.2904 (1.6); 7.2592 (0.9); 7.2463 (0.9); 7.2365 (0.9); 7.2318 (0.9); 7.2235 (0.9); 7.2187 (0.9); 7.2091 (0.9); 7.1960 (0.9); 6.7815 (0.5); 6.7726 (0.8); 6.7617 (0.7); 6.7526 (1.1); 6.7445 (0.6); 6.7302 (0.7); 4.4234 (0.7); 4.4147 (0.7); 4.2087 (1.3); 4.1923 (1.3); 4.1830 (1.7); 4.1666 (1.2); 4.0381 (1.2); 4.0204 (1.2); 3.7565 (1.2); 3.7477 (1.2); 3.7309 (1.1); 3.7220 (1.0); 3.3336 (39.2); 3.0399 (1.3); 3.0204 (1.4); 2.9972 (1.6); 2.9776 (1.4); 2.6742 (0.9); 2.6697 (1.3); 2.6651 (0.9); 2.5231 (3.8); 2.5184 (5.9); 2.5098 (74.2); 2.5052 (160.2); 2.5006 (222.2); 2.4960 (154.5); 2.4914 (69.9); 2.4596 (1.8); 2.4501 (2.0); 2.3321 (1.1); 2.3274 (1.3); 2.3228 (1.0); 2.0726 (0.8); 1.9879 (5.6); 1.9080 (16.0); 1.1956 (0.6); 1.1924 (1.6); 1.1776 (1.5); 1.1746 (3.3); 1.1568 (1.6); 0.0080 (1.8); -0.0002 (59.8); -0.0085 (1.8) I.4-107: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.9138 (0.9); 7.7011 (0.9); 7.6888 (1.0); 7.6779 (1.0); 7.6656 (1.0); 7.2384 (1.2); 7.2165 (1.5); 7.1938 (1.0); 7.1151 (1.0); 7.0952 (1.3); 7.0748 (1.0); 7.0592 (0.5); 5.3093 (1.2); 4.1096 (0.6); 3.3770 (1.0); 3.3588 (1.1); 3.3405 (0.5); 3.3153 (78.0); 3.0986 (0.9); 3.0804 (2.8); 3.0621 (2.8); 3.0440 (1.0); 2.8783 (0.6); 2.5236 (0.6); 2.5188 (0.9); 2.5102 (13.2); 2.5056 (29.0); 2.5010 (40.8); 2.4964 (28.9); 2.4918 (13.1); 2.4759 (0.6); 1.2514 (0.9); 1.2333 (1.8); 1.2150 (1.1); 1.2084 (7.7); 1.1902 (16.0); 1.1720 (7.3) I.4-108: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0482 (3.6); 8.0425 (3.5); 7.7415 (3.2); 7.1805 (1.3); 7.1643 (1.3); 7.1441 (2.4); 7.1426 (2.3); 7.1238 (2.7); 7.1223 (2.6); 6.9123 (2.4); 6.9067 (2.2); 6.8922 (1.9); 6.8865 (1.9); 4.3738 (0.8); 4.3548 (1.2); 4.3348 (0.7); 4.2503 (0.5); 4.2424 (0.7); 4.2338 (0.8); 4.2252 (0.7); 4.0560 (0.6); 4.0382 (1.7); 4.0204 (1.8); 4.0026 (0.6); 3.6382 (1.7); 3.6220 (1.8); 3.6129 (2.0); 3.5968 (1.8); 3.4792 (3.2); 3.1401 (1.6); 3.1314 (1.5); 3.1149 (1.4); 3.1060 (1.7); 2.6823 (1.7); 2.6701 (0.5); 2.6625 (2.0); 2.6406 (2.2); 2.6208 (1.9); 2.5236 (1.3); 2.5188 (1.9); 2.5102 (25.0); 2.5056 (54.3); 2.5010 (76.2); 2.4963 (52.7); 2.4917 (23.0); 2.4510 (0.5); 2.1450 (16.0); 2.1303 (1.8); 2.0991 (1.5); 2.0886 (1.5); 1.9880 (8.2); 1.9084 (6.3); 1.7189 (0.9); 1.7106 (0.9); 1.7066 (0.9); 1.7015 (0.8); 1.6907 (1.0); 1.6719 (0.8); 1.6506 (1.2); 1.6427 (1.5); 1.6287 (1.0); 1.5473 (0.9); 1.5406 (1.2); 1.5298 (1.8); 1.5194 (2.2); 1.5146 (2.4); 1.4912 (1.2); 1.4724 (0.7); 1.1993 (0.6); 1.1924 (2.5); 1.1811 (1.3); 1.1746 (5.0); 1.1629 (0.6); 1.1569 (2.4); 0.0081 (1.6); - 0.0002 (57.4); -0.0086 (1.6) I.4-109: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.5431 (4.5); 7.4852 (3.1); 7.4629 (3.7); 7.4183 (6.8); 7.3961 (9.0); 7.3355 (3.5); 7.3130 (2.7); 7.2706 (9.0); 7.2488 (6.4); 6.6210 (2.7); 6.6023 (2.6); 3.6159 (2.4); 3.3066 (157.2); 3.1717 (2.4); 2.9945 (4.1); 2.9821 (4.2); 2.6694 (4.3); 2.6379 (2.4); 2.6169 (2.5); 2.5962 (2.7); 2.5093 (240.8); 2.5049 (488.2); 2.5004 (646.4); 2.4960 (461.7); 2.4918 (227.0); 2.3278 (3.5); 2.2025 (2.4); 1.1762 (2.5); 0.8441 (13.1); 0.8304 (16.0); 0.8145 (12.6); 0.0008 (104.7); -0.0002 (141.1) I.4-110: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.8350 (0.5); 8.5445 (6.6); 7.4856 (1.0); 7.4632 (1.4); 7.4317 (1.0); 7.4239 (11.7); 7.4185 (3.7); 7.4069 (4.1); 7.4015 (16.0); 7.3938 (1.7); 7.3353 (1.4); 7.3131 (1.0); 7.2803 (1.6); 7.2725 (15.7); 7.2672 (4.2); 7.2555 (3.5); 7.2503 (11.7); 7.2424 (1.1); 6.6189 (3.4); 6.6020 (3.5); 5.7531 (0.5); 4.5364 (0.6); 4.5135 (1.5); 4.4929 (2.7); 4.4730 (1.6); 4.4493 (0.6); 4.2754 (0.7); 4.2704 (0.9); 4.2651 (0.9); 4.2581 (1.6); 4.2487 (1.5); 4.2402 (1.6); 4.2328 (0.9); 4.2279 (1.0); 4.2224 (0.7); 3.7248 (3.4); 3.7077 (3.5); 3.6997 (4.0); 3.6827 (3.4); 3.3085 (65.1); 3.2638 (3.5); 3.2537 (3.4); 3.2388 (3.0); 3.2287 (3.0); 2.6742 (0.8); 2.6696 (1.1); 2.6649 (0.8); 2.6426 (3.5); 2.6223 (3.8); 2.6007 (4.5); 2.5804 (4.1); 2.5230 (3.3); 2.5183 (4.8); 2.5096 (62.4); 2.5051 (133.0); 2.5005 (183.5); 2.4959 (127.9); 2.4914 (57.6); 2.3319 (0.8); 2.3273 (1.1); 2.3227 (0.8); 2.2116 (0.7); 2.1936 (4.6); 2.1865 (3.0); 2.1817 (4.6); 2.1619 (4.3); 2.1518 (4.2); 2.1393 (5.4); 2.1128 (1.0); 2.0195 (1.0); 2.0076 (2.1); 1.9945 (2.6); 1.9885 (2.9); 1.9825 (2.2); 1.9747 (2.6); 1.9694 (1.7); 1.9629 (1.9); 1.9492 (0.8); 1.6619 (1.0); 1.6553 (0.8); 1.6460 (2.9); 1.6368 (2.2); 1.6327 (2.7); 1.6216 (5.2); 1.6082 (2.8); 1.5969 (2.3); 1.5821 (0.8); 0.0080 (3.4); -0.0002 (100.2); -0.0086 (2.7) I.4-111: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0566 (3.2); 8.0509 (3.2); 7.7183 (3.0); 7.1515 (1.6); 7.1461 (2.6); 7.1445 (2.4); 7.1349 (1.6); 7.1258 (2.6); 7.1242 (2.5); 6.9153 (2.1); 6.9096 (2.1); 6.8953 (1.8); 6.8895 (1.8); 5.7535 (3.4); 4.5290 (0.6); 4.5055 (1.2); 4.4854 (0.6); 4.2643 (0.5); 4.2567 (0.7); 4.2477 (0.8); 4.2387 (0.7); 3.7415 (1.5); 3.7251 (1.6); 3.7162 (1.8); 3.6998 (1.5); 3.3155 (73.7); 3.2787 (1.5); 3.2698 (1.5); 3.2534 (1.4); 3.2446 (1.3); 2.6924 (1.6); 2.6725 (1.9); 2.6505 (2.0); 2.6306 (1.8); 2.5236 (1.0); 2.5189 (1.3); 2.5102 (15.9); 2.5056 (34.3); 2.5010 (47.8); 2.4963 (33.1); 2.4917 (14.4); 2.2024 (0.7); 2.1997 (0.7); 2.1928 (0.8); 2.1750 (1.4); 2.1684 (1.2); 2.1654 (1.1); 2.1525 (2.8); 2.1434 (16.0); 2.1109 (1.4); 2.1001 (1.4); 2.0178 (0.9); 2.0074 (1.0); 2.0024 (1.2); 1.9921 (1.0); 1.9880 (2.3); 1.9830 (1.0); 1.9745 (0.8); 1.9084 (1.1); 1.6543 (1.2); 1.6453 (1.0); 1.6411 (1.2); 1.6299 (2.2); 1.6166 (1.2); 1.6053 (1.0); 1.1747 (0.8); 0.0081 (0.6); -0.0002 (21.8); -0.0086 (0.6) I.4-112: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0339 (3.4); 8.0282 (3.2); 7.7662 (2.7); 7.2047 (1.4); 7.1880 (1.3); 7.1409 (2.2); 7.1394 (2.1); 7.1206 (2.6); 7.1191 (2.5); 6.9094 (2.2); 6.9039 (2.1); 6.8894 (1.8); 6.8837 (1.8); 5.7542 (5.0); 4.2098 (0.5); 4.2024 (0.7); 4.1933 (0.8); 4.1842 (0.7); 3.5755 (1.9); 3.5590 (2.0); 3.5505 (2.3); 3.5340 (1.9); 3.3137 (41.8); 3.0715 (1.6); 3.0624 (1.6); 3.0465 (1.5); 3.0374 (1.4); 2.6751 (2.0); 2.6698 (1.1); 2.6654 (1.8); 2.6550 (1.9); 2.6490 (0.7); 2.6344 (1.6); 2.6131 (1.3); 2.5234 (1.3); 2.5187 (1.8); 2.5100 (31.4); 2.5054 (69.6); 2.5007 (97.8); 2.4961 (68.3); 2.4915 (30.1); 2.4554 (0.8); 2.4507 (0.9); 2.4461 (0.6); 2.3276 (0.6); 2.1439 (16.0); 2.1299 (1.5); 2.0989 (1.3); 2.0881 (1.3); 1.8026 (0.5); 1.2339 (0.5); 0.6924 (0.8); 0.6740 (1.5); 0.6726 (1.3); 0.6643 (5.0); 0.6579 (2.3); 0.6524 (2.6); 0.6498 (2.2); 0.6461 (3.9); 0.6447 (3.5); 0.6397 (2.9); 0.6340 (2.0); 0.6192 (0.5); 0.6094 (0.6); 0.0080 (1.4); 0.0040 (0.5); -0.0002 (51.5); -0.0050 (0.8); -0.0058 (0.6); -0.0066 (0.6); -0.0085 (1.5) I.4-113: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.0480 (3.5); 8.0423 (3.4); 7.7135 (3.1); 7.1457 (2.5); 7.1442 (2.4); 7.1357 (1.7); 7.1254 (3.1); 7.1239 (3.2); 6.9144 (2.3); 6.9088 (2.2); 6.8943 (1.9); 6.8886 (1.9); 4.2509 (0.5); 4.2433 (0.8); 4.2343 (0.9); 4.2255 (0.8); 4.2177 (0.6); 4.2115 (0.7); 4.1945 (1.4); 4.1775 (1.9); 4.1606 (1.4); 4.1435 (0.5); 3.6037 (1.7); 3.5875 (1.8); 3.5784 (2.1); 3.5622 (1.8); 3.3137 (135.0); 3.2637 (0.9); 3.1190 (1.6); 3.1100 (1.6); 3.0937 (1.5); 3.0848 (1.5); 2.6751 (2.1); 2.6700 (0.6); 2.6553 (2.0); 2.6335 (2.3); 2.6137 (2.0); 2.5233 (1.3); 2.5186 (1.8); 2.5100 (27.0); 2.5054 (59.2); 2.5008 (82.7); 2.4961 (57.5); 2.4915 (25.6); 2.4508 (0.6); 2.3275 (0.5); 2.2530 (0.8); 2.1429 (16.0); 2.1362 (2.6); 2.1251 (1.8); 2.0943 (1.6); 2.0835 (1.6); 1.0880 (11.0); 1.0710 (12.4); 1.0681 (12.5); 1.0510 (10.9); -0.0002 (0.9) I.4-114: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.2242 (3.7); 8.2178 (3.6); 8.1096 (1.9); 8.1055 (2.0); 8.0890 (3.9); 8.0848 (3.7); 8.0683 (2.1); 8.0641 (2.0); 7.7308 (1.5); 7.7227 (13.1); 7.7172 (3.7); 7.7055 (4.3); 7.7000 (15.2); 7.6920 (1.3); 7.4543 (1.8); 7.4463 (16.0); 7.4408 (4.1); 7.4292 (3.9); 7.4237 (13.2); 7.4157 (1.0); 7.1991 (5.0); 7.1953 (3.3); 7.1836 (3.7); 7.1786 (3.3); 7.1748 (2.9); 7.1697 (2.2); 7.1660 (2.2); 7.1493 (2.6); 7.1456 (2.6); 7.1033 (1.7); 7.0845 (3.4); 7.0642 (2.0); 6.9689 (1.5); 6.9646 (1.7); 6.9561 (1.8); 6.9515 (2.2); 6.9457 (1.8); 6.9371 (1.8); 6.9329 (1.8); 6.9256 (0.9); 6.9171 (0.8); 6.9128 (0.8); 4.4108 (1.1); 4.4042 (1.6); 4.3944 (1.8); 4.3854 (1.5); 4.3783 (1.1); 4.1604 (3.2); 4.1441 (3.2); 4.1351 (4.1); 4.1189 (2.9); 4.0381 (1.0); 4.0201 (0.9); 3.6860 (2.7); 3.6770 (2.8); 3.6606 (2.6); 3.6518 (2.5); 3.4317 (0.6); 3.3951 (0.6); 3.3619 (4.1); 3.3482 (0.7); 3.3445 (1.2); 3.3116 (309.1); 3.2842 (1.3); 3.2622 (4.4); 3.2113 (0.6); 2.9836 (3.2); 2.9641 (3.4); 2.9411 (3.8); 2.9216 (3.4); 2.6741 (1.5); 2.6696 (2.3); 2.6650 (1.6); 2.5553 (3.1); 2.5507 (4.4); 2.5461 (3.2); 2.5231 (5.3); 2.5184 (7.7); 2.5098 (128.3); 2.5052 (283.5); 2.5006 (400.5); 2.4959 (283.8); 2.4913 (129.9); 2.4601 (3.2); 2.4554 (5.1); 2.4508 (6.6); 2.4461 (5.3); 2.4419 (5.7); 2.4313 (4.1); 2.4000 (3.7); 2.3890 (3.1); 2.3321 (2.0); 2.3274 (2.5); 2.3226 (1.9); 2.0726 (2.8); 1.9879 (4.5); 1.1923 (1.3); 1.1745 (2.6); 1.1567 (1.4); 0.0499 (1.6); 0.0080 (4.6); -0.0002 (196.3); -0.0085 (7.0); -0.0500 (2.5); - 0.1497 (0.6) I.4-115: 1H-NMR (400.0 MHz, CDCl3): δ= 8.2947 (2.1); 8.2889 (2.2); 8.2818 (0.8); 8.2758 (0.7); 7.5497 (1.3); 7.5442 (1.2); 7.5384 (1.5); 7.5269 (1.7); 7.5179 (2.6); 7.3557 (0.6); 7.3125 (0.9); 7.2979 (1.1); 7.2882 (1.0); 7.2591 (305.6); 7.2292 (2.6); 7.2081 (0.7); 7.1360 (0.6); 7.1144 (0.6); 7.1082 (0.6); 7.0602 (1.8); 7.0393 (2.6); 7.0175 (1.8); 6.9951 (2.7); 6.9607 (1.3); 6.9547 (1.2); 6.9392 (1.1); 6.9332 (1.1); 5.7406 (0.6); 4.6191 (0.5); 4.2260 (0.6); 4.2104 (0.7); 4.1990 (0.8); 4.1837 (2.4); 3.8671 (0.8); 3.8417 (0.7); 3.0938 (1.0); 3.0749 (0.9); 3.0512 (0.8); 3.0320 (0.7); 2.5295 (0.7); 2.4864 (0.6); 1.5391 (34.9); 1.4150 (1.2); 1.3965 (2.0); 1.3783 (1.1); 1.3321 (11.9); 1.2831 (16.0); 1.2552 (16.0); 0.8800 (2.1); 0.8620 (1.3); 0.0688 (3.2); 0.0079 (4.1); -0.0002 (126.2); -0.0085 (5.3); -0.1498 (0.5) I.4-116: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.7619 (2.7); 9.2140 (8.5); 8.3127 (0.3); 8.2370 (3.1); 8.2229 (3.2); 8.1260 (8.6); 8.1118 (8.9); 7.6984 (6.6); 7.6861 (7.2); 7.6809 (4.5); 7.6755 (7.9); 7.6633 (7.4); 7.6523 (4.2); 7.6479 (4.0); 7.6018 (9.9); 7.5975 (10.4); 7.3798 (1.9); 7.3753 (1.9); 7.3658 (1.9); 7.3613 (1.9); 7.2686 (5.1); 7.2641 (5.3); 7.2543 (5.3); 7.2498 (5.7); 7.2397 (7.3); 7.2175 (12.4); 7.1954 (10.8); 7.1797 (4.7); 6.0235 (0.5); 6.0143 (0.4); 5.8449 (0.3); 5.8353 (0.4); 4.5961 (0.3); 4.4274 (1.5); 4.4194 (2.1); 4.4105 (2.3); 4.4015 (2.2); 4.3939 (1.6); 4.3735 (0.5); 4.1597 (3.5); 4.1428 (3.7); 4.1344 (4.4); 4.1175 (3.4); 3.9020 (16.0); 3.7017 (3.7); 3.6924 (3.8); 3.6763 (3.4); 3.6672 (3.4); 3.5087 (1.0); 3.4789 (0.6); 3.4661 (0.7); 3.4579 (0.8); 3.3481 (424.6); 3.2684 (2.3); 3.2523 (1.1); 3.2322 (0.5); 3.2202 (0.5); 3.1702 (11.1); 2.9536 (3.2); 2.9334 (3.4); 2.9110 (4.0); 2.8909 (3.9); 2.6730 (1.3); 2.5435 (1.9); 2.5085 (185.1); 2.5043 (242.2); 2.5000 (182.9); 2.4811 (6.9); 2.4490 (3.5); 2.4379 (3.4); 2.3355 (1.0); 2.3310 (1.3); 1.2347 (1.8); 0.0076 (0.9); -0.0002 (26.0); -0.0081 (1.2) I.4-117: 1H-NMR (400.0 MHz, d6-DMSO): δ= 7.8771 (1.3); 7.8722 (2.4); 7.8677 (2.1); 7.8523 (1.2); 3.3116 (8.3); 3.0960 (1.9); 3.0778 (6.1); 3.0595 (6.2); 3.0414 (2.1); 2.5232 (1.2); 2.5185 (1.8); 2.5100 (17.2); 2.5055 (34.2); 2.5009 (45.7); 2.4964 (32.1); 2.4919 (14.7); 1.2090 (7.7); 1.1908 (16.0); 1.1725 (7.4); 0.0080 (0.8); -0.0002 (18.9); -0.0085 (0.6) I.4-118: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6630 (7.7); 7.4744 (0.8); 7.4654 (8.6); 7.4597 (2.9); 7.4530 (9.2); 7.4479 (4.8); 7.4425 (10.2); 7.4359 (3.2); 7.4301 (9.6); 7.4211 (0.9); 7.1426 (0.9); 7.1336 (9.8); 7.1279 (2.8); 7.1208 (1.3); 7.1163 (3.1); 7.1115 (16.0); 7.1062 (3.2); 7.1017 (1.1); 7.0947 (2.7); 7.0890 (8.6); 7.0799 (0.7); 3.3080 (83.7); 2.6741 (0.9); 2.6695 (1.2); 2.6649 (0.8); 2.5342 (0.7); 2.5229 (3.5); 2.5182 (4.9); 2.5096 (65.7); 2.5050 (141.4); 2.5004 (195.6); 2.4958 (137.9); 2.4913 (62.2); 2.3318 (0.8); 2.3272 (1.2); 2.3226 (0.8); 0.0080 (2.1); - 0.0002 (68.1); -0.0085 (1.9) I.4-119: 1H-NMR (400.0 MHz, d6-DMSO): δ= 11.5869 (4.7); 7.9095 (6.9); 7.8879 (8.1); 7.8622 (7.1); 7.8463 (16.0); 7.8394 (14.5); 7.8267 (14.5); 7.8198 (14.7); 7.8032 (5.5); 7.7327 (6.4); 7.7140 (6.7); 7.6778 (3.9); 7.6609 (6.2); 7.6397 (5.8); 7.6196 (3.0); 7.3531 (3.3); 7.3338 (4.6); 7.1686 (3.2); 4.1729 (3.0); 3.6547 (3.4); 3.5116 (4.3); 3.3121 (1279.9); 2.8937 (3.0); 2.6740 (19.0); 2.6693 (25.2); 2.6648 (18.9); 2.5227 (80.7); 2.5177 (130.0); 2.5093 (1577.5); 2.5048 (3217.1); 2.5003 (4312.8); 2.4958 (3095.8); 2.4914 (1524.0); 2.3317 (20.8); 2.3270 (26.0); 2.3228 (19.2); 2.0720 (6.8); 1.0215 (4.7); 1.0059 (4.8); 0.1463 (2.9); 0.0079 (25.3); -0.0002 (735.5); -0.0085 (35.4); -0.1493 (3.1) I.4-120: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7114 (16.0); 8.6185 (4.5); 8.1851 (1.8); 8.1670 (2.2); 8.1445 (1.7); 8.1239 (2.5); 8.0587 (6.8); 8.0412 (7.0); 8.0291 (1.7); 8.0099 (2.4); 7.9963 (6.8); 7.8263 (9.7); 7.8059 (11.6); 7.7105 (9.3); 7.6905 (10.0); 7.6604 (5.4); 7.6408 (9.1); 7.6210 (4.5); 7.4474 (0.7); 7.3399 (6.1); 7.3209 (10.2); 7.3014 (4.8); 7.2288 (0.8); 4.2601 (1.8); 4.2424 (5.5); 4.2246 (5.9); 4.2030 (5.7); 4.1852 (5.6); 4.1674 (1.7); 3.3099 (326.0); 3.1150 (1.0); 3.0974 (1.1); 3.0848 (1.1); 2.6740 (4.1); 2.6695 (5.3); 2.6651 (3.8); 2.5093 (371.9); 2.5049 (688.9); 2.5004 (878.4); 2.4959 (608.1); 2.4914 (272.6); 2.4621 (1.2); 2.3316 (3.9); 2.3271 (4.9); 2.3226 (3.6); 2.0722 (0.9); 1.2840 (6.1); 1.2663 (12.8); 1.2487 (11.9); 1.2311 (13.2); 1.2134 (5.8); 1.1948 (2.1); 1.1767 (4.1); 1.1586 (1.9); 1.0226 (0.8); 0.1463 (1.0); 0.0077 (13.5); -0.0002 (249.3); -0.0083 (8.9); - 0.1491 (1.0) I.4-121: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9959 (8.6); 8.9918 (9.3); 8.9853 (9.3); 8.9811 (8.9); 8.5644 (16.0); 8.5528 (7.5); 8.5490 (7.2); 8.5319 (7.2); 8.5282 (6.8); 8.0947 (9.4); 8.0735 (10.3); 8.0422 (7.9); 8.0390 (8.3); 8.0217 (9.2); 8.0186 (9.1); 7.8235 (7.5); 7.8201 (7.9); 7.8050 (11.3); 7.8017 (10.3); 7.7294 (11.7); 7.7192 (14.3); 7.7151 (12.9); 7.7097 (16.0); 7.6997 (12.2); 7.6957 (11.0); 7.6906 (8.1); 7.6795 (8.1); 7.6687 (7.9); 7.6587 (7.6); 7.6480 (7.5); 7.6207 (4.9); 7.6169 (4.7); 7.5989 (8.4); 7.5809 (4.9); 7.5770 (4.5); 7.1464 (6.1); 7.1445 (5.9); 7.1274 (10.4); 7.1085 (5.4); 7.1066 (5.0); 4.6119 (0.6); 4.5949 (1.9); 4.5828 (3.4); 4.5722 (2.9); 4.5658 (3.4); 4.5532 (2.0); 4.5364 (0.7); 4.3659 (6.3); 4.3491 (6.3); 4.3413 (7.7); 4.3246 (5.8); 3.8771 (6.4); 3.8666 (6.3); 3.8525 (5.9); 3.8421 (5.6); 3.0141 (5.7); 2.9942 (6.2); 2.9719 (7.2); 2.9521 (6.3); 2.6770 (0.7); 2.6724 (1.0); 2.6682 (0.7); 2.5516 (1.2); 2.5256 (5.0); 2.5122 (59.7); 2.5078 (121.2); 2.5035 (162.6); 2.4990 (115.8); 2.4945 (59.0); 2.4633 (5.3); 2.4508 (5.4); 2.3348 (0.8); 2.3303 (1.0); 2.3258 (0.7); 0.0079 (2.1); -0.0002 (46.8); -0.0081 (1.7) I.4-122: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7168 (2.3); 8.0175 (6.3); 7.9967 (7.0); 7.8315 (1.5); 7.8109 (1.8); 7.7402 (11.0); 7.7198 (9.0); 7.7135 (5.0); 7.7075 (10.7); 7.7023 (6.4); 7.6971 (10.0); 7.6896 (6.1); 7.6850 (9.8); 7.6758 (1.8); 7.6601 (1.8); 7.6271 (12.2); 7.6099 (12.2); 7.5802 (6.4); 7.5607 (3.6); 7.3400 (0.9); 7.3211 (1.5); 7.3020 (0.8); 7.2570 (1.3); 7.2485 (8.8); 7.2433 (3.1); 7.2265 (16.0); 7.2163 (5.6); 7.2095 (4.4); 7.2041 (9.6); 7.1974 (7.4); 7.1785 (3.6); 4.4231 (0.6); 4.4141 (1.2); 4.4057 (2.1); 4.3975 (2.9); 4.3887 (3.2); 4.3802 (3.0); 4.3720 (2.3); 4.3634 (1.4); 4.3543 (0.8); 4.1761 (4.5); 4.1600 (4.6); 4.1508 (5.5); 4.1348 (4.4); 3.6888 (4.7); 3.6806 (4.5); 3.6634 (4.4); 3.6553 (4.2); 3.3164 (21.1); 2.9885 (4.2); 2.9692 (4.4); 2.9461 (5.2); 2.9268 (4.8); 2.5576 (0.6); 2.5533 (0.6); 2.5072 (55.5); 2.5031 (69.5); 2.4991 (50.2); 2.4316 (5.3); 2.4217 (5.1); 2.3891 (4.4); 2.3793 (4.3); 2.3302 (0.5); 1.2357 (2.0); -0.0002 (16.0); -0.0084 (0.8) I.4-123: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.3106 (10.7); 8.9537 (7.0); 8.9495 (7.4); 8.9434 (7.6); 8.9391 (7.1); 8.4679 (6.5); 8.4636 (6.5); 8.4471 (7.1); 8.4429 (6.7); 8.2376 (0.8); 8.2236 (0.7); 8.1388 (11.6); 8.1246 (12.3); 8.0003 (6.2); 7.9970 (6.4); 7.9800 (7.4); 7.9766 (7.2); 7.7694 (5.6); 7.7659 (5.7); 7.7509 (9.1); 7.7475 (7.9); 7.6851 (7.8); 7.6659 (9.8); 7.6464 (5.7); 7.6246 (16.0); 7.6225 (15.0); 7.6128 (7.3); 7.6025 (6.7); 7.5920 (6.5); 7.2977 (7.0); 7.2930 (6.6); 7.2835 (7.0); 7.2789 (6.5); 7.2516 (5.9); 7.2344 (6.0); 4.5778 (2.7); 4.5599 (2.9); 4.5477 (1.8); 4.5297 (0.7); 4.3478 (4.8); 4.3306 (5.0); 4.3231 (6.0); 4.3062 (4.7); 4.1007 (1.1); 4.0878 (3.3); 4.0747 (3.4); 4.0619 (1.2); 3.8783 (4.8); 3.8675 (4.8); 3.8536 (4.6); 3.8428 (4.5); 3.3119 (162.2); 3.2801 (1.4); 3.1769 (13.4); 3.1758 (16.7); 3.1638 (13.2); 3.1627 (16.2); 3.0884 (1.0); 2.9716 (4.3); 2.9516 (4.6); 2.9294 (5.5); 2.9096 (5.0); 2.6749 (1.7); 2.6704 (2.2); 2.6660 (1.6); 2.5526 (1.5); 2.5391 (6.0); 2.5250 (10.1); 2.5101 (137.4); 2.5058 (272.4); 2.5013 (357.5); 2.4970 (259.2); 2.4929 (127.5); 2.3328 (1.7); 2.3282 (2.2); 2.3239 (1.6); 2.0730 (2.1); 1.1888 (1.7); 1.1710 (2.9); 1.1533 (1.7); 0.0009 (40.6); -0.0002 (52.5); -0.0085 (2.1) I.4-124: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.7151 (2.2); 8.0209 (6.7); 8.0001 (7.4); 7.8299 (1.4); 7.8095 (1.8); 7.7370 (11.1); 7.7073 (1.7); 7.6882 (12.5); 7.6854 (15.3); 7.6805 (4.5); 7.6661 (16.0); 7.6637 (14.9); 7.6581 (3.0); 7.6369 (7.3); 7.6237 (9.7); 7.6048 (7.4); 7.5785 (5.9); 7.5591 (3.2); 7.4114 (1.6); 7.4065 (10.8); 7.4014 (3.7); 7.3932 (2.2); 7.3879 (14.5); 7.3852 (12.7); 7.3710 (3.9); 7.3664 (11.3); 7.3610 (1.6); 7.3500 (0.5); 7.3392 (1.0); 7.3200 (1.5); 7.3009 (0.7); 7.2139 (3.9); 7.1948 (6.7); 7.1757 (3.4); 7.1679 (3.3); 7.1653 (5.8); 7.1627 (3.6); 7.1468 (9.3); 7.1310 (2.4); 7.1284 (4.1); 7.1258 (2.4); 4.4236 (0.6); 4.4144 (1.2); 4.4061 (2.0); 4.3980 (2.8); 4.3892 (3.1); 4.3805 (2.9); 4.3724 (2.2); 4.3637 (1.4); 4.3547 (0.7); 4.1867 (5.9); 4.1708 (5.8); 4.1611 (7.2); 4.1453 (5.6); 3.6984 (5.1); 3.6904 (5.1); 3.6728 (4.7); 3.6649 (4.6); 3.3133 (24.2); 2.9985 (5.6); 2.9792 (6.0); 2.9561 (6.9); 2.9368 (6.2); 2.6708 (0.5); 2.5242 (1.4); 2.5195 (2.2); 2.5107 (28.2); 2.5062 (61.6); 2.5017 (86.2); 2.4971 (62.0); 2.4926 (28.9); 2.4350 (5.4); 2.4253 (5.4); 2.3926 (4.6); 2.3830 (4.6); 2.3284 (0.5); 1.2350 (2.2); 0.0080 (1.3); -0.0002 (43.3); -0.0085 (1.4) I.4-125: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6605 (7.9); 8.4457 (4.0); 7.6992 (3.7); 7.6868 (4.0); 7.6816 (2.4); 7.6762 (4.4); 7.6638 (4.1); 7.4649 (8.3); 7.4525 (9.1); 7.4474 (5.0); 7.4421 (9.8); 7.4351 (3.3); 7.4297 (9.3); 7.4058 (3.7); 7.3934 (4.0); 7.3882 (2.1); 7.3829 (4.3); 7.3706 (4.1); 7.2359 (4.3); 7.2137 (6.4); 7.1913 (3.8); 7.1336 (9.5); 7.1278 (2.9); 7.1114 (16.0); 7.0947 (2.6); 7.0890 (8.5); 7.0786 (4.3); 7.0563 (6.8); 7.0338 (3.3); 6.7281 (2.2); 6.7111 (2.2); 4.3855 (1.2); 4.1411 (2.1); 4.1243 (2.0); 4.1163 (2.6); 4.0994 (2.0); 3.6781 (2.1); 3.6682 (2.0); 3.6528 (1.8); 3.6434 (1.7); 3.3574 (2.2); 3.3397 (2.3); 3.3072 (558.8); 3.2575 (1.0); 3.1746 (0.9); 3.1615 (0.9); 2.9329 (2.0); 2.9130 (2.1); 2.8906 (2.5); 2.8709 (2.3); 2.6738 (6.6); 2.6693 (9.1); 2.6647 (6.6); 2.5551 (3.9); 2.5513 (4.5); 2.5228 (26.7); 2.5180 (37.0); 2.5093 (512.2); 2.5048 (1095.1); 2.5002 (1516.1); 2.4957 (1073.3); 2.4911 (493.7); 2.4527 (3.1); 2.4214 (1.9); 2.4103 (2.0); 2.3317 (6.4); 2.3270 (9.2); 2.3225 (6.5); 2.3180 (3.2); 2.0719 (1.3); 0.1462 (2.8); 0.0505 (1.2); 0.0331 (1.6); 0.0079 (21.2); - 0.0002 (689.6); -0.0085 (20.9); -0.1494 (2.6) I.4-126: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.9561 (8.6); 8.9518 (9.3); 8.9457 (9.4); 8.9413 (9.1); 8.6487 (1.6); 8.5274 (11.2); 8.4636 (7.3); 8.4593 (7.5); 8.4427 (8.0); 8.4384 (7.6); 7.9966 (6.8); 7.9930 (7.5); 7.9761 (8.0); 7.9725 (8.1); 7.7685 (7.0); 7.7649 (7.6); 7.7501 (11.3); 7.7464 (10.2); 7.6837 (10.3); 7.6635 (10.7); 7.6449 (6.6); 7.6192 (8.5); 7.6088 (8.3); 7.5985 (8.1); 7.5880 (8.1); 7.4611 (2.0); 7.4582 (2.5); 7.4533 (0.8); 7.4394 (3.2); 7.4367 (2.8); 7.4231 (10.5); 7.4202 (13.2); 7.4153 (4.0); 7.4060 (4.4); 7.4013 (16.0); 7.3987 (13.9); 7.3934 (1.9); 7.2956 (2.2); 7.2905 (0.7); 7.2771 (2.7); 7.2745 (2.2); 7.2603 (1.0); 7.2555 (3.4); 7.2503 (11.7); 7.2454 (3.5); 7.2318 (14.2); 7.2292 (11.8); 7.2151 (3.6); 7.2105 (10.3); 7.2054 (1.3); 6.9855 (0.6); 6.9827 (1.0); 6.9798 (0.6); 6.9643 (1.8); 6.9487 (0.5); 6.9459 (0.9); 6.9431 (0.5); 6.9306 (3.0); 6.9278 (5.6); 6.9249 (3.2); 6.9118 (4.5); 6.9094 (9.4); 6.9071 (4.7); 6.8939 (2.5); 6.8910 (4.5); 6.8882 (2.4); 6.8165 (6.0); 6.7992 (6.1); 4.5954 (0.5); 4.5823 (1.1); 4.5783 (1.4); 4.5714 (1.4); 4.5654 (2.8); 4.5589 (2.1); 4.5543 (2.1); 4.5480 (2.9); 4.5350 (1.6); 4.5307 (1.3); 4.5178 (0.7); 4.3426 (6.0); 4.3257 (6.2); 4.3181 (7.6); 4.3013 (5.6); 3.8545 (5.5); 3.8436 (5.4); 3.8300 (5.1); 3.8191 (4.9); 3.3147 (45.9); 2.9632 (5.4); 2.9433 (6.0); 2.9212 (6.9); 2.9014 (6.0); 2.6706 (0.7); 2.5241 (1.9); 2.5194 (2.9); 2.5107 (38.1); 2.5061 (83.8); 2.5016 (119.0); 2.4969 (82.4); 2.4923 (39.1); 2.4609 (4.8); 2.4479 (4.7); 2.3329 (0.5); 2.3284 (0.7); 2.3237 (0.5); 1.2338 (1.3); 0.0080 (1.0); -0.0002 (35.3); -0.0085 (1.1) I.4-127: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1886 (4.7); 8.6684 (1.3); 8.6553 (1.3); 8.2365 (1.1); 8.2224 (1.1); 8.1255 (6.0); 8.1113 (6.2); 7.8990 (4.3); 7.8935 (1.8); 7.8820 (2.7); 7.8763 (13.0); 7.8525 (13.3); 7.8468 (2.8); 7.8352 (2.0); 7.8299 (4.2); 7.6955 (1.2); 7.6918 (1.4); 7.6534 (1.2); 7.6488 (1.2); 7.5981 (5.9); 7.5935 (6.1); 7.5862 (1.0); 7.5772 (0.9); 7.5728 (0.9); 7.3840 (0.8); 7.3792 (0.7); 7.3699 (0.7); 7.3651 (0.7); 7.2689 (3.6); 7.2641 (3.4); 7.2546 (3.4); 7.2498 (3.4); 7.1902 (2.5); 7.1736 (2.5); 4.4450 (1.1); 4.4361 (1.2); 4.4265 (1.1); 4.4195 (0.8); 4.2048 (2.1); 4.1878 (2.2); 4.1792 (2.6); 4.1622 (2.0); 3.7694 (2.0); 3.7600 (2.0); 3.7439 (1.8); 3.7342 (1.8); 3.7199 (0.8); 3.3613 (0.6); 3.3567 (0.6); 3.3435 (0.6); 3.3088 (186.4); 3.0206 (2.1); 3.0003 (2.3); 2.9776 (2.6); 2.9573 (2.3); 2.6743 (1.5); 2.6696 (2.1); 2.6651 (1.5); 2.5584 (2.3); 2.5472 (3.1); 2.5230 (5.8); 2.5182 (8.9); 2.5096 (118.7); 2.5051 (255.8); 2.5006 (354.0); 2.4960 (250.7); 2.4915 (115.2); 2.4406 (0.6); 2.3320 (1.6); 2.3274 (2.1); 2.3228 (1.5); 2.1959 (0.5); 2.1774 (1.1); 2.1588 (0.6); 1.2358 (16.0); 1.0906 (0.7); 0.8701 (0.6); 0.8623 (0.6); 0.8539 (2.1); 0.8363 (0.9); 0.0080 (1.3); -0.0002 (43.8); -0.0085 (1.4) I.4-127: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.8930 (0.7); 9.2858 (3.8); 8.6685 (0.9); 8.6549 (1.0); 8.2350 (1.2); 8.2209 (1.2); 8.1246 (5.1); 8.1104 (5.5); 7.8990 (3.7); 7.8819 (2.2); 7.8763 (11.0); 7.8516 (10.9); 7.8294 (3.6); 7.7046 (1.0); 7.7003 (1.1); 7.6466 (1.1); 7.6419 (1.2); 7.5976 (5.2); 7.5930 (5.6); 7.5819 (0.8); 7.5776 (0.7); 7.3735 (0.7); 7.3689 (0.7); 7.3596 (0.6); 7.3547 (0.7); 7.2698 (3.1); 7.2650 (3.0); 7.2555 (3.1); 7.2507 (3.2); 7.2409 (2.1); 7.2245 (2.1); 4.4350 (1.1); 4.2057 (1.9); 4.1886 (1.9); 4.1800 (2.3); 4.1632 (1.7); 4.0387 (0.8); 4.0210 (0.9); 3.7700 (1.8); 3.7604 (1.7); 3.7442 (1.6); 3.7349 (1.5); 3.3464 (3.2); 3.1215 (1.1); 3.1092 (1.2); 3.1032 (3.5); 3.0912 (3.4); 3.0850 (3.6); 3.0730 (3.5); 3.0670 (1.2); 3.0548 (1.1); 3.0210 (1.8); 3.0007 (2.0); 2.9780 (2.3); 2.9576 (2.1); 2.6707 (0.6); 2.5573 (2.3); 2.5465 (3.0); 2.5241 (2.2); 2.5106 (39.6); 2.5061 (84.0); 2.5016 (116.1); 2.4970 (80.7); 2.4925 (36.2); 2.3287 (0.6); 1.9882 (3.5); 1.9091 (11.3); 1.2352 (4.4); 1.2025 (7.7); 1.1930 (1.5); 1.1843 (16.0); 1.1751 (2.4); 1.1661 (7.5); 1.1573 (1.1); 0.8533 (0.7); 0.0081 (1.3); -0.0002 (39.9); -0.0085 (1.1) I.4-128: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6633 (7.3); 8.4637 (5.8); 7.8999 (5.6); 7.8770 (16.0); 7.8492 (15.7); 7.8264 (6.1); 7.4652 (7.9); 7.4530 (8.6); 7.4476 (4.8); 7.4424 (10.0); 7.4301 (9.2); 7.4047 (5.2); 7.3925 (5.6); 7.3817 (6.8); 7.3694 (6.1); 7.1336 (9.4); 7.1114 (15.6); 7.0890 (8.4); 7.0781 (6.9); 7.0558 (10.2); 7.0336 (5.5); 6.7475 (3.1); 6.7308 (3.4); 4.1880 (2.8); 4.1706 (3.0); 4.1620 (3.4); 4.1451 (3.2); 3.7455 (3.0); 3.7206 (2.3); 3.7097 (2.3); 3.3080 (256.1); 3.0014 (2.7); 2.9816 (2.9); 2.9587 (3.5); 2.9387 (3.1); 2.6691 (3.5); 2.5555 (2.2); 2.5337 (3.6); 2.5228 (10.4); 2.5183 (11.7); 2.5095 (205.2); 2.5049 (458.1); 2.5003 (647.4); 2.4957 (459.1); 2.4912 (211.7); 2.4505 (3.0); 2.3273 (3.6); 0.0081 (5.0); -0.0002 (169.5); -0.0086 (5.0) I.4-129: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4363 (6.3); 8.0675 (4.1); 8.0461 (4.3); 7.9110 (5.7); 7.8939 (3.3); 7.8882 (16.0); 7.8611 (15.9); 7.8554 (3.4); 7.8438 (2.3); 7.8384 (5.8); 7.7013 (3.7); 7.6978 (3.9); 7.6821 (3.9); 7.6781 (4.3); 7.6252 (3.2); 7.6091 (5.0); 7.5915 (3.6); 7.5734 (2.1); 7.5694 (1.9); 7.1401 (2.9); 7.1374 (2.8); 7.1187 (4.6); 7.1020 (2.5); 7.0993 (2.4); 4.4259 (1.6); 4.2188 (2.7); 4.2023 (2.8); 4.1929 (3.2); 4.1768 (2.4); 3.7790 (2.4); 3.7709 (2.4); 3.7541 (2.2); 3.7460 (2.2); 3.3107 (160.2); 3.0529 (2.6); 3.0333 (2.9); 3.0101 (3.1); 2.9902 (2.9); 2.6698 (1.4); 2.5400 (4.9); 2.5236 (4.7); 2.5100 (83.8); 2.5054 (182.6); 2.5008 (255.0); 2.4962 (180.0); 2.4917 (81.2); 2.4734 (2.8); 2.3274 (1.5); 2.0725 (2.0); 0.0081 (1.6); -0.0002 (58.8); - 0.0085 (1.6) I.4-130: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4283 (12.0); 8.0794 (8.4); 8.0584 (8.9); 7.7119 (8.3); 7.6992 (15.5); 7.6890 (10.2); 7.6771 (16.0); 7.6252 (6.2); 7.6088 (9.4); 7.5908 (6.8); 7.5697 (3.7); 7.2468 (8.6); 7.2239 (15.0); 7.2025 (7.9); 7.1348 (5.1); 7.1148 (7.9); 7.0959 (4.2); 4.4066 (3.7); 4.1760 (4.2); 4.1605 (4.9); 4.1501 (5.6); 4.1342 (4.3); 3.7042 (5.3); 3.6791 (5.1); 3.3115 (355.7); 2.9868 (4.3); 2.9669 (5.0); 2.9441 (5.2); 2.9239 (5.0); 2.6700 (3.6); 2.5003 (611.3); 2.4519 (7.0); 2.4423 (6.4); 2.4098 (4.6); 2.3991 (4.7); 2.3278 (3.6); -0.0002 (72.8) I.4-131: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1892 (10.8); 8.1259 (13.9); 8.1117 (14.4); 7.6675 (11.4); 7.6647 (14.5); 7.6455 (16.0); 7.6431 (14.0); 7.6057 (14.5); 7.6012 (14.7); 7.3962 (10.9); 7.3911 (3.7); 7.3775 (14.9); 7.3607 (4.0); 7.3561 (10.8); 7.2716 (8.8); 7.2668 (8.5); 7.2574 (8.4); 7.2526 (8.3); 7.2038 (5.6); 7.1869 (5.6); 7.1580 (5.7); 7.1395 (9.4); 7.1210 (4.1); 4.4338 (1.9); 4.4261 (2.6); 4.4169 (3.1); 4.4080 (2.8); 4.4004 (2.0); 4.3805 (0.7); 4.1715 (5.7); 4.1546 (5.8); 4.1460 (7.0); 4.1292 (5.5); 3.7176 (5.4); 3.7083 (5.3); 3.6922 (4.9); 3.6830 (4.7); 2.9624 (5.5); 2.9422 (5.9); 2.9198 (7.0); 2.8998 (6.3); 2.6716 (0.7); 2.5248 (1.9); 2.5115 (40.1); 2.5070 (87.8); 2.5025 (127.2); 2.4979 (88.3); 2.4933 (44.2); 2.4604 (4.7); 2.4492 (4.9); 2.3297 (0.7); - 0.0002 (9.4) I.4-132: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.4251 (10.2); 8.0863 (6.5); 8.0656 (7.1); 7.6996 (5.8); 7.6959 (6.6); 7.6810 (14.9); 7.6786 (16.0); 7.6769 (14.2); 7.6593 (14.1); 7.6568 (12.0); 7.6511 (1.8); 7.6366 (5.1); 7.6201 (5.2); 7.6122 (4.2); 7.6081 (3.7); 7.5934 (4.4); 7.5901 (5.9); 7.5869 (3.8); 7.5722 (3.6); 7.5682 (3.3); 7.4097 (1.4); 7.4048 (9.7); 7.3996 (3.0); 7.3916 (1.9); 7.3862 (12.8); 7.3833 (10.4); 7.3693 (3.4); 7.3646 (9.8); 7.3592 (1.3); 7.1667 (2.7); 7.1640 (5.0); 7.1614 (2.8); 7.1456 (8.3); 7.1350 (5.0); 7.1323 (5.3); 7.1300 (2.8); 7.1272 (4.0); 7.1245 (2.3); 7.1160 (7.7); 7.1135 (7.6); 7.0970 (4.4); 7.0943 (4.3); 4.4368 (0.5); 4.4270 (1.0); 4.4187 (1.7); 4.4105 (2.3); 4.4019 (2.6); 4.3927 (2.4); 4.3849 (1.8); 4.3760 (1.1); 4.3666 (0.6); 4.1888 (5.1); 4.1728 (5.1); 4.1633 (6.2); 4.1473 (4.8); 3.7169 (4.4); 3.7089 (4.3); 3.6914 (4.0); 3.6834 (3.9); 3.3624 (2.1); 3.3437 (0.6); 3.3119 (343.1); 3.2885 (0.6); 3.2633 (1.4); 2.9976 (4.9); 2.9781 (5.2); 2.9551 (6.0); 2.9357 (5.4); 2.6744 (1.2); 2.6698 (1.7); 2.6652 (1.2); 2.5601 (0.8); 2.5553 (1.2); 2.5507 (1.5); 2.5460 (0.9); 2.5232 (4.7); 2.5186 (6.8); 2.5099 (97.0); 2.5053 (211.0); 2.5007 (294.3); 2.4961 (207.3); 2.4916 (94.6); 2.4591 (5.3); 2.4492 (4.6); 2.4166 (3.8); 2.4068 (4.0); 2.3321 (1.2); 2.3275 (1.7); 2.3228 (1.2); 2.0723 (1.0); 1.9879 (0.8); 1.2352 (0.8); 1.1746 (0.5); 0.0080 (1.6); -0.0002 (53.5); -0.0085 (1.5) I.4-133: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6353 (1.2); 8.3708 (2.4); 7.4613 (1.6); 7.4585 (1.8); 7.4537 (0.6); 7.4396 (2.1); 7.4370 (1.9); 7.3892 (2.4); 7.3864 (3.1); 7.3816 (0.9); 7.3676 (3.8); 7.3650 (3.3); 7.2949 (1.6); 7.2764 (2.0); 7.2741 (1.6); 7.2597 (0.5); 7.2552 (1.4); 7.2365 (2.7); 7.2315 (0.9); 7.2179 (3.5); 7.2156 (2.8); 7.2103 (0.7); 7.2012 (0.9); 7.1967 (2.3); 6.9821 (0.7); 6.9637 (1.2); 6.9615 (0.6); 6.9453 (0.6); 6.9191 (0.7); 6.9163 (1.3); 6.9135 (0.9); 6.8980 (2.2); 6.8956 (1.1); 6.8824 (0.6); 6.8796 (1.0); 6.8768 (0.5); 6.5411 (1.3); 6.5241 (1.3); 4.2503 (0.7); 4.2416 (0.6); 4.2327 (0.7); 4.1903 (1.1); 4.1733 (1.5); 4.1564 (1.1); 3.5918 (1.4); 3.5749 (1.5); 3.5667 (1.7); 3.5499 (1.5); 3.3282 (0.6); 3.3213 (6.2); 3.1112 (1.4); 3.1012 (1.4); 3.0861 (1.3); 3.0762 (1.3); 2.6329 (1.5); 2.6127 (1.6); 2.5913 (1.8); 2.5711 (1.7); 2.5104 (3.8); 2.5059 (8.2); 2.5013 (11.4); 2.4967 (8.0); 2.4922 (3.7); 2.1717 (1.5); 2.1596 (1.5); 2.1301 (1.3); 2.1180 (1.3); 1.2347 (0.7); 1.1018 (0.5); 1.0805 (9.0); 1.0641 (16.0); 1.0476 (8.7) I.4-134: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6754 (7.9); 7.4657 (8.3); 7.4600 (2.9); 7.4533 (8.8); 7.4481 (4.8); 7.4428 (9.8); 7.4361 (3.2); 7.4305 (9.2); 7.4218 (0.9); 7.1424 (1.0); 7.1335 (9.5); 7.1279 (2.8); 7.1114 (16.0); 7.0946 (2.5); 7.0890 (8.3); 7.0546 (0.6); 3.3091 (56.3); 2.6693 (0.9); 2.5232 (2.4); 2.5184 (3.6); 2.5096 (55.4); 2.5051 (120.2); 2.5005 (167.8); 2.4960 (118.8); 2.4915 (54.5); 2.3275 (0.9); 1.2354 (4.0); 1.0762 (1.0); 1.0600 (1.4); 1.0446 (0.9); 0.0080 (1.3); -0.0002 (43.8); -0.0086 (1.4) I.4-135: 1H-NMR (400.0 MHz, CDCl3): δ= 8.3320 (3.6); 8.3300 (3.7); 8.3212 (0.6); 8.3098 (3.8); 8.3073 (3.5); 7.7105 (3.8); 7.5480 (1.4); 7.5441 (2.2); 7.5349 (3.7); 7.5305 (5.1); 7.5257 (4.5); 7.5217 (1.6); 7.5155 (4.0); 7.5113 (4.7); 7.5071 (2.8); 7.5031 (1.0); 7.2620 (36.2); 7.1388 (1.6); 7.1229 (1.6); 7.0512 (2.4); 7.0488 (2.4); 7.0323 (3.7); 7.0298 (4.1); 7.0132 (2.1); 7.0107 (2.0); 4.5123 (0.6); 4.4950 (1.4); 4.4816 (1.4); 4.4642 (0.6); 4.4315 (0.7); 4.4145 (1.8); 4.3976 (2.5); 4.3807 (1.8); 4.3637 (0.7); 3.6972 (2.2); 3.6835 (2.3); 3.6702 (2.8); 3.6565 (2.5); 3.4070 (2.6); 3.4029 (2.5); 3.3801 (2.2); 3.3760 (2.1); 2.9208 (2.1); 2.9022 (2.2); 2.8782 (2.6); 2.8597 (2.3); 2.2891 (2.2); 2.2838 (2.2); 2.2466 (2.0); 2.2413 (1.9); 1.1669 (15.6); 1.1579 (15.9); 1.1500 (16.0); 1.1409 (15.1); -0.0002 (13.8) I.4-136: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1709 (0.9); 8.7109 (16.0); 7.8263 (9.3); 7.8057 (11.6); 7.7288 (0.8); 7.7102 (9.3); 7.7073 (9.7); 7.6904 (9.7); 7.6874 (10.3); 7.6601 (5.2); 7.6408 (8.7); 7.6214 (4.4); 7.5493 (0.5); 7.5052 (0.7); 7.4853 (0.6); 7.4551 (0.6); 7.3395 (6.2); 7.3205 (9.9); 7.3014 (4.7); 4.2794 (2.8); 3.3410 (0.5); 3.3075 (184.8); 3.1624 (0.5); 2.6787 (0.8); 2.6741 (1.7); 2.6695 (2.4); 2.6649 (1.7); 2.6602 (0.8); 2.6198 (0.6); 2.5635 (0.5); 2.5365 (1.5); 2.5318 (1.9); 2.5229 (7.8); 2.5182 (10.7); 2.5095 (126.4); 2.5050 (271.8); 2.5004 (378.3); 2.4957 (264.2); 2.4912 (117.7); 2.4498 (0.7); 2.4450 (0.6); 2.3365 (0.7); 2.3319 (1.5); 2.3272 (2.2); 2.3226 (1.5); 2.3180 (0.7); 2.0721 (0.9); 1.2357 (2.0); 1.0202 (0.5); 0.0080 (2.8); -0.0002 (92.7); - 0.0085 (2.6) I.4-137: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1350 (0.7); 9.1302 (0.7); 8.8737 (0.6); 8.8588 (0.6); 7.7353 (0.5); 7.7283 (0.5); 7.7203 (0.5); 7.7132 (0.5); 7.6996 (0.7); 7.6872 (0.8); 7.6787 (1.7); 7.6664 (1.8); 7.6558 (1.7); 7.6436 (1.6); 7.2727 (1.7); 7.2506 (2.7); 7.2392 (1.0); 7.2337 (0.7); 7.2282 (1.6); 7.2171 (1.3); 7.1945 (0.7); 4.2182 (0.5); 4.2079 (0.5); 4.1909 (0.5); 3.7757 (0.6); 3.7474 (0.6); 3.3101 (36.0); 3.1047 (1.9); 3.0865 (6.2); 3.0683 (6.4); 3.0501 (2.1); 3.0229 (0.6); 2.9990 (0.7); 2.9782 (0.6); 2.6742 (0.7); 2.6697 (1.0); 2.6650 (0.7); 2.5605 (0.7); 2.5537 (0.8); 2.5230 (2.9); 2.5182 (4.6); 2.5096 (59.4); 2.5051 (125.4); 2.5005 (172.3); 2.4960 (121.2); 2.4915 (55.0); 2.4450 (0.6); 2.3320 (0.8); 2.3274 (1.0); 2.3227 (0.8); 2.0725 (0.6); 1.2035 (7.7); 1.1853 (16.0); 1.1671 (7.4); 0.0080 (2.3); -0.0002 (67.2); -0.0086 (1.8) I.4-138: 1H-NMR (400.0 MHz, d6-DMSO): δ= 3.3134 (3.7); 3.0912 (0.8); 3.0735 (2.4); 3.0642 (2.8); 3.0557 (2.6); 3.0462 (2.7); 3.0282 (0.9); 2.5057 (15.3); 2.5013 (20.4); 2.4969 (15.2); 1.2141 (7.9); 1.1959 (16.0); 1.1777 (7.6); -0.0002 (5.5) I.4-139: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.3080 (2.9); 8.3646 (0.7); 8.3487 (0.7); 7.6715 (2.2); 7.6518 (2.6); 7.6447 (1.4); 7.6235 (1.1); 7.5008 (2.8); 7.4959 (1.3); 7.4796 (5.4); 7.4748 (1.2); 7.4664 (2.0); 7.4611 (5.2); 7.4557 (0.9); 7.4031 (2.4); 7.3926 (6.4); 7.3894 (8.4); 7.3839 (5.4); 7.3734 (4.6); 7.3707 (5.7); 7.3683 (5.4); 7.3632 (3.4); 7.3524 (2.5); 7.3495 (2.6); 7.3312 (3.5); 7.3158 (1.0); 7.3130 (1.4); 7.2283 (0.8); 7.2098 (1.2); 7.1914 (0.7); 7.1798 (1.0); 7.1735 (5.0); 7.1677 (2.4); 7.1611 (2.0); 7.1550 (5.7); 7.1515 (7.5); 7.1460 (3.1); 7.1401 (3.8); 7.1339 (6.2); 7.1271 (2.0); 7.1205 (1.8); 6.8720 (1.4); 6.7752 (2.5); 6.7728 (2.3); 6.7589 (9.7); 6.7578 (10.0); 6.7434 (3.2); 6.7381 (12.8); 6.7306 (0.8); 6.6296 (0.6); 4.1846 (0.6); 4.1674 (0.6); 4.1591 (0.7); 4.1419 (0.5); 3.7724 (0.8); 3.7639 (0.8); 3.7469 (0.7); 3.7382 (0.6); 3.3160 (2.2); 2.9689 (0.6); 2.9483 (0.6); 2.9259 (0.7); 2.9057 (0.7); 2.7984 (0.7); 2.7926 (0.6); 2.7796 (0.7); 2.5644 (0.7); 2.5540 (0.8); 2.5217 (2.2); 2.5087 (18.2); 2.5044 (35.2); 2.5000 (47.4); 2.4955 (34.3); 2.4910 (16.7); 2.3321 (0.5); 2.3227 (0.6); 2.1837 (2.2); 1.3572 (16.0); 1.0835 (1.5); 1.0655 (3.0); 1.0475 (1.4); 0.0079 (0.9); -0.0002 (19.6); -0.0084 (0.9) I.4-140: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2974 (0.6); 9.1280 (0.7); 9.1209 (0.7); 8.8690 (0.7); 8.8546 (0.7); 7.7300 (0.5); 7.7226 (0.6); 7.7147 (0.5); 7.7076 (0.5); 3.3106 (22.5); 3.1012 (1.3); 3.0848 (3.0); 3.0668 (3.0); 3.0491 (1.1); 2.6697 (0.5); 2.6247 (0.5); 2.5830 (0.6); 2.5097 (28.6); 2.5052 (59.6); 2.5007 (81.0); 2.4962 (57.0); 2.4917 (26.3); 1.2054 (7.7); 1.1872 (16.0); 1.1690 (7.4); 1.0809 (2.5); 1.0641 (4.8); 1.0473 (2.5); 0.0079 (1.1); -0.0002 (32.5); -0.0087 (1.1) I.4-141: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6358 (5.4); 8.4050 (6.1); 7.7035 (5.8); 7.6980 (2.1); 7.6911 (6.0); 7.6857 (3.4); 7.6804 (6.6); 7.6738 (2.2); 7.6680 (6.3); 7.4787 (0.7); 7.4585 (6.5); 7.4557 (8.0); 7.4368 (9.4); 7.4344 (8.4); 7.3925 (5.6); 7.3897 (7.2); 7.3709 (8.8); 7.3684 (7.9); 7.2947 (6.7); 7.2761 (8.8); 7.2550 (6.0); 7.2373 (12.3); 7.2322 (3.8); 7.2156 (16.0); 7.1978 (7.0); 7.1928 (6.8); 6.9821 (3.1); 6.9637 (5.3); 6.9453 (2.4); 6.9199 (2.8); 6.9015 (4.9); 6.8831 (2.2); 6.7300 (3.3); 6.7135 (3.3); 4.4004 (1.6); 4.3915 (1.7); 4.1479 (3.1); 4.1311 (3.2); 4.1227 (3.7); 4.1060 (3.1); 3.6820 (3.0); 3.6727 (2.8); 3.6570 (2.7); 3.6476 (2.6); 3.3453 (1.1); 3.3275 (1.4); 3.3122 (35.1); 2.9412 (3.1); 2.9214 (3.1); 2.8987 (3.6); 2.8789 (3.4); 2.6696 (0.8); 2.5095 (47.3); 2.5050 (100.9); 2.5005 (139.8); 2.4959 (100.0); 2.4914 (46.6); 2.4631 (3.2); 2.4517 (3.2); 2.4208 (2.6); 2.4090 (2.6); 2.3272 (0.9); 1.2353 (6.3); 1.1008 (1.2); 1.0831 (2.7); 1.0654 (1.3); 0.8538 (0.6); 0.0080 (1.4); -0.0002 (38.9); -0.0085 (1.3) I.5-1: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2201 (6.9); 8.7836 (3.8); 7.9418 (2.9); 7.6727 (11.5); 7.6698 (14.2); 7.6507 (16.0); 7.6482 (13.6); 7.6213 (2.5); 7.6022 (2.5); 7.5340 (13.3); 7.5124 (15.7); 7.4075 (11.8); 7.3889 (15.2); 7.3674 (11.3); 7.2935 (4.5); 7.2780 (3.8); 7.1680 (6.1); 7.1495 (9.8); 7.1311 (4.3); 4.9235 (2.1); 4.2620 (5.2); 4.2456 (6.0); 4.2360 (6.5); 4.2193 (5.6); 3.7946 (3.6); 3.7753 (3.3); 3.3103 (443.5); 3.0661 (4.6); 3.0463 (4.9); 3.0231 (6.2); 3.0030 (5.0); 2.6741 (4.9); 2.6694 (7.5); 2.6650 (5.2); 2.5532 (4.5); 2.5229 (19.8); 2.5182 (30.2); 2.5096 (409.3); 2.5050 (881.5); 2.5004 (1225.5); 2.4958 (857.8); 2.4912 (387.8); 2.4511 (1.9); 2.3316 (5.3); 2.3273 (7.2); 2.3226 (5.0); 0.0079 (5.2); -0.0002 (164.3); -0.0087 (4.8) I.5-2: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2290 (4.3); 8.7822 (2.0); 8.7658 (2.0); 7.9321 (1.5); 7.7130 (0.6); 7.7039 (6.5); 7.6980 (2.2); 7.6915 (6.9); 7.6861 (3.5); 7.6806 (7.3); 7.6742 (2.3); 7.6683 (6.9); 7.6591 (0.6); 7.5355 (9.1); 7.5140 (10.9); 7.3027 (2.8); 7.2964 (2.7); 7.2811 (2.3); 7.2748 (2.3); 7.2590 (0.8); 7.2498 (7.4); 7.2440 (2.2); 7.2375 (1.0); 7.2323 (2.5); 7.2279 (10.2); 7.2226 (2.4); 7.2177 (0.9); 7.2110 (2.0); 7.2052 (6.5); 7.1960 (0.5); 5.7536 (10.4); 4.9251 (0.9); 4.2515 (3.0); 4.2350 (3.4); 4.2256 (3.8); 4.2091 (3.0); 4.0559 (1.0); 4.0382 (3.2); 4.0204 (3.2); 4.0026 (1.1); 3.7848 (2.0); 3.7771 (2.0); 3.7589 (1.8); 3.7514 (1.8); 3.3104 (106.0); 3.0552 (2.7); 3.0349 (3.0); 3.0121 (3.4); 2.9920 (3.0); 2.6742 (1.1); 2.6697 (1.5); 2.6650 (1.1); 2.6604 (0.5); 2.5541 (1.6); 2.5452 (1.9); 2.5231 (4.3); 2.5184 (6.6); 2.5098 (84.5); 2.5052 (181.9); 2.5006 (253.4); 2.4959 (175.6); 2.4914 (78.1); 2.4503 (0.6); 2.3367 (0.5); 2.3321 (1.1); 2.3273 (1.5); 2.3227 (1.1); 1.9880 (16.0); 1.2409 (0.5); 1.1923 (4.4); 1.1746 (8.7); 1.1568 (4.2); 0.8583 (0.9); 0.0081 (0.9); -0.0002 (30.6); -0.0086 (0.8) I.5-3: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2489 (6.6); 8.7537 (3.2); 8.7375 (3.0); 7.9037 (2.7); 7.5385 (13.3); 7.5170 (16.0); 7.4953 (6.6); 7.4896 (7.6); 7.4699 (7.5); 7.4644 (6.2); 7.3093 (4.4); 7.3026 (4.1); 7.2876 (4.0); 7.2810 (3.4); 7.0421 (2.5); 7.0246 (2.8); 7.0190 (4.6); 6.9962 (2.8); 4.9496 (1.7); 4.2414 (3.9); 4.2243 (4.3); 4.2149 (4.7); 4.1979 (4.3); 4.0383 (1.8); 4.0202 (1.8); 3.8064 (2.9); 3.7735 (2.8); 3.3594 (1.8); 3.3083 (609.9); 3.2576 (2.8); 3.1119 (4.0); 3.0915 (4.1); 3.0682 (4.4); 3.0481 (4.4); 2.6740 (6.0); 2.6693 (8.4); 2.6647 (6.0); 2.5986 (3.3); 2.5561 (4.0); 2.5228 (28.8); 2.5181 (42.2); 2.5095 (496.7); 2.5049 (1056.8); 2.5003 (1452.4); 2.4957 (1002.6); 2.4910 (442.6); 2.4548 (3.1); 2.4500 (4.2); 2.3317 (5.9); 2.3270 (8.5); 2.3225 (5.9); 2.0721 (2.0); 1.9877 (8.7); 1.2459 (2.4); 1.1922 (2.4); 1.1745 (4.8); 1.1567 (2.3); 0.8584 (4.1); 0.8410 (1.4); -0.0002 (50.0) I.5-5: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2424 (3.5); 8.5766 (0.9); 7.6962 (1.0); 7.6688 (5.8); 7.6628 (5.7); 7.5022 (0.6); 7.4906 (2.9); 7.4849 (3.4); 7.4653 (3.5); 7.4597 (2.9); 7.4218 (3.4); 7.4157 (3.2); 7.4002 (3.0); 7.3941 (2.9); 7.0442 (0.6); 7.0389 (1.0); 7.0212 (1.2); 7.0154 (2.1); 7.0099 (1.0); 6.9981 (0.7); 6.9924 (1.1); 4.9746 (0.6); 4.2310 (1.7); 4.2136 (1.9); 4.2046 (2.2); 4.1873 (1.7); 4.0558 (1.0); 4.0380 (3.3); 4.0203 (3.3); 4.0024 (1.2); 3.7829 (1.2); 3.7749 (1.2); 3.7565 (1.1); 3.7490 (1.0); 3.3114 (79.6); 3.0911 (1.8); 3.0704 (2.0); 3.0476 (2.3); 3.0270 (2.0); 2.6743 (0.9); 2.6696 (1.3); 2.6651 (1.0); 2.5937 (1.1); 2.5847 (1.1); 2.5497 (1.5); 2.5401 (1.6); 2.5231 (4.2); 2.5185 (5.8); 2.5098 (75.4); 2.5052 (163.5); 2.5006 (227.6); 2.4959 (159.4); 2.4913 (71.0); 2.3319 (1.0); 2.3273 (1.3); 2.3227 (1.0); 1.9880 (16.0); 1.2462 (1.2); 1.1923 (4.4); 1.1745 (9.1); 1.1567 (4.5); 0.8754 (0.6); 0.8583 (2.4); 0.8407 (0.8); -0.0002 (8.6) I.5-6: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1549 (3.1); 8.3213 (0.6); 8.1436 (3.0); 8.1406 (3.2); 8.0287 (1.3); 8.0228 (1.3); 8.0199 (1.3); 8.0134 (2.0); 8.0090 (1.2); 8.0050 (1.4); 7.9992 (1.3); 7.6172 (0.7); 7.6140 (0.8); 7.6067 (6.1); 7.6045 (5.7); 7.5981 (2.8); 7.5948 (2.9); 7.5916 (3.3); 7.4133 (2.2); 7.2706 (2.0); 7.2499 (3.8); 7.2121 (2.7); 7.2066 (2.5); 7.1917 (1.3); 7.1862 (1.3); 5.7532 (12.9); 5.0027 (0.5); 4.2658 (1.4); 4.2485 (1.6); 4.2399 (1.8); 4.2227 (1.4); 4.0558 (0.6); 4.0381 (1.9); 4.0203 (1.9); 4.0025 (0.6); 3.8159 (1.1); 3.8072 (1.2); 3.7900 (1.1); 3.7813 (1.0); 3.3103 (74.5); 3.0631 (1.4); 3.0422 (1.6); 3.0197 (1.9); 2.9989 (1.7); 2.6740 (0.6); 2.6695 (0.9); 2.6648 (0.6); 2.6076 (1.2); 2.5972 (1.3); 2.5635 (1.5); 2.5528 (1.6); 2.5475 (1.3); 2.5228 (5.5); 2.5182 (6.9); 2.5095 (52.0); 2.5050 (107.5); 2.5004 (147.1); 2.4958 (103.8); 2.4912 (47.7); 2.4557 (0.9); 2.4511 (1.0); 2.4464 (0.8); 2.3318 (0.7); 2.3272 (0.9); 2.3226 (0.7); 2.1454 (16.0); 1.9878 (8.7); 1.2420 (1.9); 1.1923 (2.4); 1.1745 (4.7); 1.1567 (2.3); 0.8752 (0.7); 0.8583 (2.3); 0.8406 (1.0); -0.0002 (6.2) I.5-7: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1215 (2.8); 8.3354 (0.6); 7.6978 (3.5); 7.6919 (1.2); 7.6855 (3.8); 7.6800 (1.9); 7.6745 (4.1); 7.6681 (1.2); 7.6622 (3.8); 7.4298 (1.7); 7.2670 (2.0); 7.2460 (4.0); 7.2422 (4.4); 7.2362 (1.2); 7.2297 (0.6); 7.2246 (1.4); 7.2202 (5.4); 7.2148 (1.4); 7.2075 (2.8); 7.2023 (3.1); 7.1974 (3.8); 7.1873 (1.5); 7.1815 (1.3); 5.7533 (3.6); 4.2276 (1.5); 4.2104 (1.8); 4.2020 (2.0); 4.1848 (1.6); 3.7605 (1.1); 3.7521 (1.2); 3.7350 (1.0); 3.7265 (1.0); 3.3098 (40.4); 3.0132 (1.5); 2.9924 (1.7); 2.9702 (2.0); 2.9494 (1.8); 2.6694 (0.6); 2.5599 (0.9); 2.5494 (1.0); 2.5229 (2.1); 2.5181 (3.4); 2.5095 (34.5); 2.5050 (73.6); 2.5003 (102.0); 2.4957 (70.9); 2.4911 (31.3); 2.3272 (0.6); 2.1432 (16.0); -0.0002 (13.0) I.5-8: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2171 (3.0); 8.6059 (0.8); 8.5923 (0.8); 7.7078 (0.9); 7.6986 (4.4); 7.6928 (1.9); 7.6863 (4.3); 7.6809 (2.2); 7.6754 (4.3); 7.6689 (1.7); 7.6636 (7.8); 7.6580 (4.8); 7.4179 (3.1); 7.4118 (2.9); 7.3963 (2.7); 7.3902 (2.6); 7.2456 (4.2); 7.2398 (1.2); 7.2332 (0.6); 7.2281 (1.4); 7.2236 (5.9); 7.2183 (1.3); 7.2067 (1.1); 7.2009 (3.7); 5.7539 (16.0); 4.9410 (0.5); 4.2389 (1.7); 4.2219 (1.9); 4.2131 (2.2); 4.1962 (1.7); 4.0561 (0.7); 4.0382 (2.1); 4.0204 (2.2); 4.0026 (0.7); 3.7667 (1.1); 3.7586 (1.1); 3.7408 (1.0); 3.7333 (1.0); 3.3122 (36.2); 3.0340 (1.6); 3.0135 (1.8); 2.9910 (2.1); 2.9706 (1.8); 2.6698 (0.6); 2.5532 (0.9); 2.5440 (1.0); 2.5233 (1.7); 2.5186 (2.6); 2.5099 (32.0); 2.5054 (68.2); 2.5007 (94.9); 2.4961 (65.7); 2.4916 (29.2); 2.3275 (0.6); 1.9881 (10.4); 1.2965 (0.6); 1.2791 (1.5); 1.2667 (1.8); 1.2581 (2.5); 1.2475 (7.1); 1.1924 (3.0); 1.1746 (6.0); 1.1568 (2.9); 0.8752 (3.6); 0.8583 (14.1); 0.8407 (4.8); -0.0002 (13.6) I.5-9: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1522 (2.7); 8.3087 (0.6); 7.5024 (0.5); 7.4907 (2.6); 7.4850 (3.0); 7.4653 (3.1); 7.4597 (2.5); 7.4113 (2.1); 7.4069 (2.2); 7.2714 (2.0); 7.2506 (3.8); 7.2134 (2.8); 7.2079 (2.5); 7.1929 (1.4); 7.1874 (1.3); 7.0382 (0.5); 7.0325 (0.8); 7.0152 (1.0); 7.0095 (1.6); 7.0037 (0.9); 6.9921 (0.6); 6.9863 (0.8); 4.2207 (1.4); 4.2031 (1.6); 4.1945 (1.8); 4.1770 (1.5); 3.7728 (1.1); 3.7641 (1.1); 3.7465 (1.0); 3.7382 (1.0); 3.3102 (45.2); 3.3091 (44.5); 3.0703 (1.5); 3.0492 (1.7); 3.0268 (2.0); 3.0058 (1.7); 2.6742 (0.6); 2.6694 (0.8); 2.6648 (0.6); 2.5986 (1.0); 2.5884 (1.0); 2.5556 (0.9); 2.5441 (0.8); 2.5229 (2.9); 2.5182 (4.1); 2.5096 (50.3); 2.5050 (108.1); 2.5004 (150.2); 2.4958 (104.8); 2.4912 (46.7); 2.3318 (0.6); 2.3272 (0.9); 2.3226 (0.6); 2.1440 (16.0); -0.0002 (6.5) I.5-11: 1H-NMR (400.0 MHz, CDCl3): δ= 7.6625 (6.0); 7.6076 (4.2); 7.5716 (2.4); 7.5487 (2.3); 7.5381 (2.0); 7.5180 (16.0); 7.4941 (15.0); 7.4346 (2.4); 7.4098 (5.9); 7.3897 (6.6); 7.3683 (4.3); 7.3627 (3.6); 7.3459 (4.0); 7.3192 (15.9); 7.2968 (13.7); 7.2903 (5.5); 7.2832 (4.2); 7.2801 (4.6); 7.2793 (4.4); 7.2784 (4.6); 7.2769 (4.4); 7.2761 (4.7); 7.2753 (5.0); 7.2745 (5.3); 7.2737 (5.5); 7.2729 (5.9); 7.2720 (6.5); 7.2713 (7.2); 7.2704 (7.9); 7.2680 (14.4); 7.2593 (1102.6); 7.2495 (11.3); 7.2487 (11.0); 7.2479 (10.4); 7.2471 (9.8); 7.2463 (9.7); 7.2455 (9.5); 7.2439 (9.3); 7.2335 (10.7); 7.2257 (10.4); 7.2093 (16.7); 7.1171 (1.4); 7.0607 (1.0); 6.9953 (6.8); 6.4725 (2.2); 5.1541 (2.4); 4.2952 (2.9); 4.2799 (3.3); 4.2674 (3.8); 4.2523 (3.7); 4.1625 (0.8); 4.1470 (1.1); 4.1367 (1.1); 4.1296 (1.8); 4.1119 (1.7); 3.9511 (3.9); 3.9243 (3.9); 3.1435 (3.2); 3.1230 (3.2); 3.0993 (3.9); 3.0784 (3.9); 2.9881 (0.8); 2.9694 (0.9); 2.5423 (2.9); 2.4923 (2.5); 2.0427 (6.9); 2.0037 (0.9); 1.5534 (46.1); 1.2758 (3.4); 1.2579 (6.1); 1.2400 (2.7); 0.8989 (1.6); 0.8820 (5.0); 0.8644 (2.0); 0.4368 (1.2); 0.3305 (1.0); 0.2373 (1.6); 0.1568 (2.7); 0.1464 (1.6); 0.1263 (0.9); 0.0501 (1.8); 0.0080 (15.0); -0.0002 (436.7); -0.0085 (16.3); -0.0499 (5.4); -0.1494 (1.8) I.5-12: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1137 (2.2); 8.3451 (0.6); 7.6662 (3.8); 7.6633 (4.7); 7.6442 (5.2); 7.6416 (4.4); 7.4426 (1.7); 7.4005 (3.6); 7.3954 (1.3); 7.3820 (4.6); 7.3791 (3.7); 7.3604 (3.7); 7.2651 (1.9); 7.2444 (3.4); 7.2046 (2.4); 7.1989 (2.2); 7.1841 (1.3); 7.1785 (1.2); 7.1612 (1.9); 7.1585 (1.1); 7.1427 (3.1); 7.1243 (1.4); 5.7538 (0.8); 4.9559 (0.5); 4.2378 (1.6); 4.2208 (1.8); 4.2121 (2.0); 4.1951 (1.6); 3.7789 (1.2); 3.7701 (1.1); 3.7525 (1.1); 3.7442 (1.0); 3.3107 (103.6); 3.0234 (1.6); 3.0029 (1.8); 2.9805 (2.0); 2.9600 (1.8); 2.6740 (1.2); 2.6694 (1.7); 2.6648 (1.2); 2.5695 (1.1); 2.5604 (1.0); 2.5229 (5.2); 2.5181 (7.4); 2.5095 (96.8); 2.5049 (212.2); 2.5003 (297.5); 2.4957 (208.0); 2.4911 (93.4); 2.3317 (1.2); 2.3271 (1.7); 2.3225 (1.3); 2.1432 (16.0); 1.9878 (1.5); 1.1743 (0.8); 0.0079 (1.2); -0.0002 (43.5); -0.0086 (1.4) I.5-13: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2085 (4.3); 8.6230 (1.5); 7.7032 (1.7); 7.6669 (8.9); 7.6640 (11.9); 7.6622 (11.5); 7.6554 (7.5); 7.6450 (11.3); 7.6424 (9.4); 7.4151 (5.1); 7.4089 (5.6); 7.4034 (8.6); 7.3981 (2.9); 7.3934 (5.0); 7.3850 (11.0); 7.3633 (8.1); 7.1642 (4.1); 7.1458 (6.6); 7.1274 (3.0); 5.7538 (16.0); 4.9260 (1.2); 4.2481 (3.3); 4.2313 (3.7); 4.2220 (4.2); 4.2055 (3.5); 3.7765 (2.2); 3.7581 (2.1); 3.7501 (2.1); 3.3114 (268.8); 3.3101 (264.4); 3.2586 (1.0); 3.0436 (2.9); 3.0233 (3.2); 3.0006 (3.8); 2.9801 (3.4); 2.6742 (3.2); 2.6695 (4.4); 2.6648 (3.3); 2.5630 (2.1); 2.5229 (12.3); 2.5182 (18.3); 2.5095 (265.4); 2.5049 (583.8); 2.5003 (820.6); 2.4957 (575.5); 2.4911 (260.0); 2.4495 (2.6); 2.3318 (3.3); 2.3271 (4.9); 2.3226 (3.5); 1.2494 (0.9); 0.8583 (1.3); 0.0080 (3.0); -0.0002 (114.0); -0.0085 (3.5) I.5-14: 1H-NMR (400.0 MHz, CDCl3): δ= 7.5220 (10.8); 7.5175 (15.6); 7.5030 (5.7); 7.4816 (7.0); 7.3587 (3.2); 7.3410 (8.3); 7.3356 (6.6); 7.3200 (7.7); 7.2591 (1451.9); 7.1844 (3.5); 7.1653 (7.7); 7.1452 (3.5); 6.9951 (8.2); 6.3306 (2.3); 4.2424 (2.9); 4.2272 (2.9); 4.2153 (3.5); 4.2006 (3.0); 4.1304 (3.1); 4.1123 (3.9); 3.8812 (3.4); 3.8526 (2.9); 3.0851 (3.2); 3.0657 (3.5); 3.0403 (3.7); 3.0220 (3.5); 2.5152 (2.9); 2.4643 (2.8); 2.0434 (16.0); 1.5284 (77.9); 1.2764 (5.9); 1.2586 (10.0); 1.2406 (4.6); 0.8821 (4.9); 0.0080 (23.0); -0.0002 (598.4); -0.0085 (19.7) I.5-15: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2028 (2.2); 8.5827 (0.9); 8.5660 (0.9); 7.9203 (0.6); 7.5360 (3.9); 7.5144 (4.6); 7.3008 (1.2); 7.2945 (1.2); 7.2792 (1.0); 7.2729 (1.0); 5.7519 (0.8); 4.1900 (1.1); 4.1730 (1.5); 4.1560 (1.1); 3.6776 (1.1); 3.6607 (1.2); 3.6519 (1.3); 3.6351 (1.2); 3.3063 (39.3); 3.2269 (1.0); 3.2180 (1.0); 3.2013 (0.9); 3.1924 (0.9); 2.7346 (1.3); 2.7140 (1.4); 2.6925 (1.7); 2.6718 (1.6); 2.5228 (1.1); 2.5181 (1.5); 2.5095 (21.8); 2.5049 (47.6); 2.5003 (66.8); 2.4957 (46.9); 2.4911 (21.4); 2.2794 (0.5); 2.2699 (0.5); 1.0861 (8.6); 1.0695 (16.0); 1.0530 (8.5); -0.0002 (2.1) I.5-16: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2522 (3.0); 8.8288 (1.7); 8.8118 (1.7); 7.9403 (0.8); 7.5499 (5.8); 7.5451 (1.9); 7.5349 (6.4); 7.5286 (6.8); 7.5134 (6.2); 7.3008 (1.4); 7.2948 (1.4); 7.2795 (1.2); 7.2732 (1.1); 7.1991 (4.8); 7.1786 (4.4); 5.7574 (0.6); 4.9022 (0.6); 4.2285 (1.6); 4.2120 (1.9); 4.2024 (2.1); 4.1860 (1.7); 3.7603 (1.1); 3.7406 (1.0); 3.4059 (132.8); 3.3562 (2.0); 3.1222 (0.6); 3.1100 (0.6); 3.1038 (1.9); 3.0918 (1.9); 3.0856 (2.0); 3.0736 (1.9); 3.0675 (0.6); 3.0554 (0.6); 3.0438 (1.5); 3.0236 (1.6); 3.0009 (1.9); 2.9807 (1.6); 2.6754 (0.8); 2.6709 (1.2); 2.6664 (0.9); 2.5244 (3.6); 2.5197 (4.7); 2.5110 (54.4); 2.5064 (119.3); 2.5018 (166.6); 2.4972 (116.8); 2.4926 (51.7); 2.4566 (1.5); 2.4519 (1.9); 2.4474 (1.3); 2.3332 (0.9); 2.3286 (1.3); 2.3239 (0.9); 2.2813 (16.0); 2.0744 (0.6); 1.1987 (3.6); 1.1805 (7.6); 1.1622 (3.5); -0.0002 (0.9) I.5-17: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1984 (4.4); 8.6297 (1.7); 8.6137 (1.7); 7.9274 (0.8); 7.5352 (6.9); 7.5136 (8.1); 7.3007 (1.7); 7.2945 (1.7); 7.2790 (1.4); 7.2727 (1.4); 5.7537 (3.2); 4.7744 (0.7); 4.0380 (0.8); 4.0202 (0.8); 3.7237 (2.1); 3.7069 (2.3); 3.6977 (2.6); 3.6810 (2.2); 3.3103 (117.3); 3.2980 (2.1); 3.2806 (1.5); 3.2720 (1.5); 3.2602 (1.0); 3.0166 (2.8); 3.0064 (2.9); 2.9980 (3.2); 2.9878 (2.9); 2.9733 (0.5); 2.7735 (1.5); 2.7530 (1.7); 2.7313 (2.0); 2.7108 (1.8); 2.6740 (0.8); 2.6695 (1.2); 2.6649 (0.8); 2.5230 (2.7); 2.5183 (3.9); 2.5096 (60.5); 2.5050 (134.8); 2.5003 (190.2); 2.4957 (131.7); 2.4911 (58.0); 2.4550 (1.4); 2.4504 (1.7); 2.4458 (1.1); 2.3318 (0.9); 2.3272 (1.2); 2.3225 (0.9); 2.2985 (0.8); 2.2483 (0.7); 1.9878 (3.8); 1.8830 (0.6); 1.8648 (1.2); 1.8479 (1.6); 1.8313 (1.3); 1.8139 (0.6); 1.1922 (1.1); 1.1745 (2.3); 1.1567 (1.2); 0.8583 (0.8); 0.8450 (15.0); 0.8344 (16.0); 0.8284 (15.5); 0.8178 (14.9); 0.0079 (3.6); 0.0063 (0.8); 0.0054 (1.0); 0.0046 (1.2); 0.0037 (1.7); 0.0021 (5.2); -0.0002 (132.1); -0.0028 (5.9); -0.0044 (2.0); -0.0052 (1.5); - 0.0061 (1.2); -0.0069 (1.1); -0.0085 (3.8); -0.0108 (0.6); -0.0116 (0.5); -0.0503 (0.9) I.5-18: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2304 (1.6); 8.7993 (0.8); 8.7828 (0.8); 7.5665 (3.0); 7.5608 (1.0); 7.5492 (1.2); 7.5436 (3.4); 7.5357 (2.3); 7.5142 (2.5); 7.3011 (0.7); 7.2953 (0.7); 7.2797 (0.6); 7.2733 (0.6); 6.9614 (3.3); 6.9558 (1.0); 6.9385 (3.0); 4.2184 (0.7); 4.2018 (0.8); 4.1924 (1.0); 4.1759 (0.8); 3.7437 (16.0); 3.7220 (0.6); 3.3168 (106.8); 3.2668 (0.9); 3.0996 (0.5); 3.0940 (0.5); 3.0817 (0.5); 3.0241 (0.7); 3.0038 (0.7); 2.9811 (0.8); 2.9615 (0.7); 2.6745 (0.6); 2.6696 (0.7); 2.6652 (0.6); 2.5232 (3.6); 2.5097 (44.3); 2.5052 (90.4); 2.5007 (122.9); 2.4961 (87.1); 2.4916 (40.2); 2.4553 (1.1); 2.4507 (1.4); 2.4461 (1.1); 2.3276 (0.8); 1.1947 (1.2); 1.1765 (2.3); 1.1583 (1.1); 0.0080 (1.7); -0.0002 (58.1); -0.0085 (2.3); -0.0501 (0.5) I.5-19: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2094 (10.0); 8.6074 (3.8); 8.5906 (3.7); 7.9225 (1.9); 7.7580 (2.2); 7.7517 (2.3); 7.6757 (2.3); 7.6539 (2.9); 7.5590 (0.6); 7.5362 (13.5); 7.5147 (16.0); 7.4912 (2.1); 7.4850 (2.0); 7.4694 (1.6); 7.4632 (1.6); 7.3013 (3.9); 7.2950 (3.8); 7.2798 (3.2); 7.2734 (3.1); 5.7529 (1.5); 4.7815 (1.4); 4.3877 (0.6); 4.3687 (2.4); 4.3495 (3.5); 4.3296 (2.1); 4.3101 (0.6); 3.7125 (3.8); 3.6956 (4.2); 3.6867 (4.7); 3.6699 (4.0); 3.3510 (0.8); 3.3169 (349.3); 3.2666 (2.8); 3.2566 (3.4); 3.2482 (3.4); 3.2310 (2.9); 3.2226 (3.2); 3.1985 (0.6); 3.1123 (0.7); 3.1007 (0.8); 3.0943 (0.7); 3.0824 (0.8); 2.7464 (4.1); 2.7258 (4.6); 2.7042 (5.4); 2.6836 (4.8); 2.6751 (0.9); 2.6704 (0.9); 2.6657 (0.7); 2.5238 (2.5); 2.5191 (3.7); 2.5105 (45.5); 2.5059 (98.1); 2.5013 (137.1); 2.4967 (97.4); 2.4921 (45.3); 2.4559 (1.0); 2.4512 (1.2); 2.4468 (1.0); 2.4057 (0.5); 2.3326 (0.7); 2.3280 (1.0); 2.3234 (0.7); 2.2739 (1.8); 2.2314 (1.6); 1.7437 (1.3); 1.7205 (2.6); 1.7082 (3.3); 1.6898 (3.1); 1.6717 (2.5); 1.6567 (3.6); 1.6500 (3.8); 1.6434 (4.6); 1.6305 (3.1); 1.6088 (1.3); 1.5493 (3.2); 1.5428 (3.8); 1.5314 (6.0); 1.5154 (7.5); 1.4944 (3.7); 1.4755 (2.3); 1.1961 (2.0); 1.1779 (4.0); 1.1597 (1.9); -0.0002 (1.1) I.5-20: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2442 (4.1); 8.7625 (1.9); 8.7464 (1.9); 7.9027 (6.0); 7.8968 (3.2); 7.8857 (3.6); 7.8798 (16.0); 7.8606 (15.8); 7.8546 (2.8); 7.8433 (1.9); 7.8377 (4.4); 7.5340 (7.6); 7.5123 (9.1); 7.3059 (2.6); 7.2996 (2.5); 7.2848 (2.1); 7.2781 (2.1); 5.7512 (6.7); 4.9566 (0.9); 4.2936 (2.2); 4.2769 (2.6); 4.2674 (2.8); 4.2508 (2.2); 4.0563 (0.6); 4.0384 (1.6); 4.0205 (1.6); 4.0027 (0.5); 3.8516 (1.8); 3.8443 (1.8); 3.8261 (1.6); 3.8185 (1.6); 3.3561 (0.6); 3.3375 (0.8); 3.3023 (299.6); 3.2732 (1.0); 3.1225 (2.3); 3.1023 (2.5); 3.0791 (2.8); 3.0588 (2.4); 2.6736 (2.6); 2.6689 (3.7); 2.6643 (2.7); 2.6597 (1.3); 2.6106 (1.6); 2.5659 (1.2); 2.5329 (2.2); 2.5225 (11.2); 2.5177 (16.2); 2.5091 (211.3); 2.5045 (452.6); 2.4999 (627.8); 2.4953 (436.1); 2.4907 (195.0); 2.4686 (1.7); 2.4639 (1.2); 2.4593 (0.8); 2.3313 (2.7); 2.3267 (3.7); 2.3220 (2.6); 2.0713 (0.5); 1.9873 (7.7); 1.1924 (2.0); 1.1746 (4.1); 1.1568 (2.0); -0.0002 (15.7) I.5-22: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2370 (5.5); 8.5857 (1.4); 7.8976 (4.5); 7.8917 (2.1); 7.8806 (3.3); 7.8747 (16.0); 7.8562 (15.9); 7.8504 (3.2); 7.8389 (1.9); 7.8334 (4.4); 7.6934 (1.5); 7.6628 (7.8); 7.6568 (7.7); 7.4178 (4.5); 7.4117 (4.2); 7.3962 (3.8); 7.3902 (3.8); 4.9713 (1.0); 4.2826 (2.2); 4.2655 (2.7); 4.2566 (3.0); 4.2395 (2.3); 4.0558 (0.7); 4.0382 (2.4); 4.0204 (2.5); 4.0027 (0.8); 3.8291 (1.7); 3.8215 (1.9); 3.8033 (1.7); 3.3050 (249.4); 3.2566 (0.7); 3.1025 (2.3); 3.0818 (2.7); 3.0589 (3.0); 3.0384 (2.7); 2.6738 (2.2); 2.6691 (3.2); 2.6646 (2.3); 2.6135 (1.6); 2.6033 (1.6); 2.5603 (1.9); 2.5225 (9.7); 2.5178 (14.7); 2.5092 (180.8); 2.5046 (386.7); 2.5000 (533.6); 2.4955 (379.6); 2.4909 (174.7); 2.4468 (0.8); 2.3314 (2.3); 2.3267 (3.2); 2.3222 (2.3); 2.0718 (0.7); 1.9875 (11.1); 1.2485 (1.1); 1.1923 (3.2); 1.1745 (6.6); 1.1567 (3.1); 0.8750 (0.5); 0.8584 (1.7); 0.8411 (0.6); -0.0002 (15.5) I.5-23: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1369 (16.0); 8.3689 (4.4); 8.3520 (4.4); 7.6901 (2.8); 7.6716 (3.0); 7.6550 (3.3); 7.6507 (2.6); 7.6472 (2.4); 7.6386 (2.3); 7.6371 (2.5); 7.6316 (2.9); 7.5820 (0.5); 7.5703 (2.5); 7.5648 (2.2); 7.5633 (1.9); 7.5547 (2.1); 7.5512 (2.2); 7.5465 (3.0); 7.5359 (0.5); 7.5005 (11.9); 7.4968 (12.1); 7.4806 (14.4); 7.4769 (14.4); 7.4465 (1.1); 7.4414 (1.6); 7.4374 (0.9); 7.4277 (4.4); 7.4227 (4.8); 7.4190 (4.4); 7.4113 (8.1); 7.4038 (3.3); 7.4003 (4.1); 7.3951 (3.2); 7.3815 (1.2); 7.3763 (0.8); 7.3395 (5.7); 7.3357 (6.1); 7.3208 (10.5); 7.3170 (10.0); 7.3011 (8.3); 7.2972 (7.6); 7.2482 (6.0); 7.2441 (6.1); 7.2287 (7.8); 7.2249 (7.7); 7.2097 (3.7); 7.2057 (3.5); 5.7526 (3.2); 4.7941 (2.2); 4.5737 (1.2); 4.5560 (1.2); 4.3870 (1.0); 4.3677 (4.1); 4.3486 (6.1); 4.3287 (3.5); 4.3092 (1.0); 4.1252 (0.6); 4.1075 (0.6); 3.7028 (6.3); 3.6856 (7.1); 3.6773 (7.9); 3.6602 (6.8); 3.3460 (0.6); 3.3171 (495.1); 3.2939 (1.2); 3.2853 (1.3); 3.2811 (0.7); 3.2669 (3.7); 3.2505 (5.6); 3.2412 (5.7); 3.2263 (5.5); 3.2161 (5.3); 3.1980 (1.0); 2.7249 (8.3); 2.7042 (9.3); 2.6828 (11.0); 2.6748 (1.2); 2.6700 (1.5); 2.6621 (9.8); 2.5235 (2.8); 2.5188 (4.0); 2.5102 (60.0); 2.5056 (132.8); 2.5009 (187.4); 2.4963 (130.3); 2.4917 (57.7); 2.4554 (1.4); 2.4508 (1.6); 2.4462 (1.3); 2.4417 (0.8); 2.4104 (0.6); 2.4058 (0.6); 2.3368 (0.5); 2.3324 (1.0); 2.3277 (1.4); 2.3232 (1.0); 2.2900 (3.1); 2.2803 (3.2); 2.2484 (2.6); 2.2379 (2.6); 1.7391 (2.1); 1.7276 (3.3); 1.7199 (4.4); 1.7052 (5.4); 1.6978 (5.0); 1.6881 (4.8); 1.6825 (4.9); 1.6694 (4.2); 1.6551 (5.9); 1.6487 (6.2); 1.6424 (7.4); 1.6273 (5.0); 1.6072 (2.0); 1.5699 (2.1); 1.5477 (5.0); 1.5386 (6.0); 1.5300 (9.3); 1.5167 (11.5); 1.5128 (12.3); 1.4926 (5.5); 1.4734 (3.5); 1.3402 (1.4); 1.3225 (3.0); 1.3048 (1.4); 1.2509 (0.7); 1.2331 (1.6); 1.2154 (0.7); 1.1943 (0.7); 1.1761 (1.3); 1.1578 (0.8); 1.1544 (1.6); 1.1367 (3.2); 1.1190 (1.4); -0.0002 (1.8) I.5-24: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.3900 (4.8); 9.3774 (1.9); 8.5873 (1.1); 8.0105 (0.6); 7.8894 (2.9); 7.8832 (3.2); 7.5575 (8.0); 7.5359 (10.0); 7.5301 (5.0); 7.5146 (1.6); 7.5085 (6.6); 7.5031 (4.0); 7.4973 (4.7); 7.4778 (4.3); 7.4721 (3.4); 7.3331 (2.4); 7.3268 (2.4); 7.3116 (2.2); 7.3053 (2.2); 7.3019 (2.6); 7.2954 (2.3); 7.2803 (2.2); 7.2738 (1.9); 7.0451 (0.9); 7.0394 (1.5); 7.0220 (1.8); 7.0163 (2.9); 7.0105 (1.4); 6.9932 (1.5); 4.7183 (0.7); 4.2475 (2.0); 4.2287 (2.2); 4.2224 (2.3); 4.2036 (1.9); 4.0558 (0.6); 4.0381 (1.8); 4.0203 (1.9); 4.0025 (0.7); 3.6492 (2.2); 3.6332 (2.2); 3.6240 (2.0); 3.6083 (1.9); 3.3608 (0.6); 3.3104 (278.1); 3.2603 (1.9); 2.8269 (0.9); 2.8103 (1.3); 2.7918 (0.9); 2.6742 (1.9); 2.6696 (2.6); 2.6648 (1.8); 2.5510 (0.6); 2.5230 (6.8); 2.5184 (9.3); 2.5097 (138.6); 2.5051 (308.8); 2.5004 (435.4); 2.4958 (303.0); 2.4912 (134.8); 2.4664 (1.4); 2.4596 (1.9); 2.4551 (2.7); 2.4505 (3.3); 2.4457 (2.5); 2.4004 (0.8); 2.3319 (2.0); 2.3273 (2.7); 2.3225 (2.0); 1.9879 (8.9); 1.2524 (16.0); 1.2344 (15.7); 1.1961 (1.2); 1.1923 (3.1); 1.1745 (5.5); 1.1567 (2.7); 1.1432 (1.7); 1.1246 (1.8); 0.8752 (0.9); 0.8584 (4.0); 0.8407 (1.4); 0.1458 (0.7); 0.0080 (6.4); 0.0055 (1.3); 0.0047 (1.6); -0.0002 (240.1); -0.0051 (3.8); -0.0059 (3.2); -0.0068 (2.8); -0.0085 (7.4); -0.0503 (1.7); -0.1495 (0.8) I.5-25: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1671 (3.1); 8.5717 (1.1); 8.5560 (1.1); 7.7082 (0.7); 7.6890 (0.7); 7.5567 (0.6); 7.5532 (1.1); 7.5470 (5.8); 7.5423 (1.8); 7.5304 (2.0); 7.5257 (6.5); 7.5194 (0.8); 7.4982 (2.6); 7.4946 (2.6); 7.4783 (3.1); 7.4746 (3.0); 7.4284 (0.7); 7.4233 (0.7); 7.4197 (0.7); 7.4121 (1.2); 7.4010 (0.6); 7.3390 (1.2); 7.3352 (1.2); 7.3202 (2.2); 7.3165 (2.1); 7.3005 (1.7); 7.2967 (1.6); 7.2461 (1.3); 7.2420 (1.3); 7.2265 (1.7); 7.2228 (1.7); 7.2075 (1.0); 7.2036 (1.3); 7.1958 (4.8); 7.1754 (4.3); 5.7553 (0.5); 4.9352 (0.5); 4.2175 (1.6); 4.2006 (1.9); 4.1916 (2.1); 4.1748 (1.7); 3.7571 (1.1); 3.7491 (1.1); 3.7314 (1.0); 3.7236 (1.0); 3.3676 (0.6); 3.3175 (134.2); 3.2672 (0.9); 3.0224 (1.6); 3.0019 (1.8); 2.9795 (2.1); 2.9591 (1.8); 2.6698 (0.6); 2.5460 (1.1); 2.5365 (0.9); 2.5233 (1.7); 2.5186 (2.4); 2.5099 (36.2); 2.5053 (80.0); 2.5007 (112.5); 2.4961 (78.5); 2.4915 (35.0); 2.4552 (0.7); 2.4506 (1.0); 2.4459 (0.7); 2.3321 (0.6); 2.3275 (0.7); 2.3228 (0.5); 2.2802 (16.0); 1.9882 (1.0); 1.1921 (0.9); 1.1743 (1.7); 1.1564 (0.8); 1.1359 (0.5); 0.0080 (1.8); 0.0046 (0.6); -0.0002 (72.0); -0.0052 (1.2); -0.0060 (0.9); -0.0069 (0.8); -0.0085 (2.2); -0.0503 (0.6) I.5-26: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1835 (4.9); 8.5556 (1.5); 8.5392 (1.5); 7.7276 (1.2); 7.7196 (11.4); 7.7141 (3.6); 7.7024 (4.3); 7.6968 (14.8); 7.6888 (2.3); 7.6769 (1.2); 7.6550 (0.8); 7.6508 (0.7); 7.6472 (0.7); 7.6387 (0.6); 7.6371 (0.6); 7.6312 (0.7); 7.5701 (0.6); 7.5547 (0.5); 7.5511 (0.6); 7.5467 (0.7); 7.5461 (0.7); 7.5005 (4.0); 7.4968 (4.1); 7.4806 (4.9); 7.4769 (4.8); 7.4584 (1.4); 7.4503 (14.3); 7.4448 (3.9); 7.4413 (0.9); 7.4395 (0.8); 7.4331 (3.5); 7.4276 (13.4); 7.4225 (1.6); 7.4190 (1.7); 7.4112 (1.9); 7.4036 (0.8); 7.4002 (1.1); 7.3949 (0.8); 7.3421 (1.9); 7.3383 (2.0); 7.3234 (3.6); 7.3196 (3.4); 7.3037 (2.8); 7.2998 (2.6); 7.2505 (2.1); 7.2465 (2.2); 7.2310 (2.7); 7.2272 (2.7); 7.2121 (1.3); 7.2081 (1.2); 5.7551 (12.8); 4.9594 (0.8); 4.2406 (2.5); 4.2236 (2.9); 4.2147 (3.2); 4.1978 (2.6); 4.0561 (1.1); 4.0382 (3.4); 4.0204 (3.4); 4.0026 (1.1); 3.7806 (1.8); 3.7725 (1.8); 3.7548 (1.6); 3.7467 (1.6); 3.3222 (83.2); 3.2723 (0.7); 3.0531 (2.6); 3.0326 (2.9); 3.0100 (3.3); 2.9895 (2.9); 2.5752 (1.4); 2.5653 (1.4); 2.5319 (1.3); 2.5239 (1.8); 2.5195 (1.9); 2.5107 (15.5); 2.5061 (34.2); 2.5015 (48.1); 2.4968 (33.6); 2.4923 (14.9); 1.9887 (16.0); 1.3235 (0.8); 1.1925 (4.8); 1.1747 (9.4); 1.1569 (4.7); 1.1368 (0.9); -0.0002 (4.6) I.5-27: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1289 (4.4); 8.4001 (1.4); 8.3830 (1.4); 7.6788 (0.9); 7.4988 (3.1); 7.4951 (3.2); 7.4789 (3.7); 7.4752 (3.7); 7.3385 (1.5); 7.3348 (1.6); 7.3197 (2.9); 7.3160 (2.8); 7.3001 (2.1); 7.2963 (1.9); 7.2461 (1.6); 7.2421 (1.7); 7.2266 (2.2); 7.2230 (2.2); 7.2076 (1.0); 7.2038 (1.0); 5.7534 (3.5); 4.7886 (0.8); 3.7134 (2.0); 3.6964 (2.2); 3.6877 (2.5); 3.6707 (2.2); 3.3122 (146.8); 3.2927 (2.7); 3.2757 (1.9); 3.2666 (1.7); 3.2615 (1.6); 3.0494 (0.7); 3.0307 (0.8); 3.0161 (3.0); 2.9979 (5.4); 2.9801 (2.9); 2.9652 (0.8); 2.9468 (0.7); 2.7508 (1.7); 2.7300 (1.9); 2.7086 (2.3); 2.6879 (2.1); 2.6741 (0.6); 2.6696 (0.8); 2.6646 (0.5); 2.5229 (2.4); 2.5182 (3.5); 2.5096 (41.6); 2.5050 (89.9); 2.5004 (125.6); 2.4959 (90.5); 2.4913 (43.4); 2.4590 (0.8); 2.4544 (1.1); 2.4499 (1.3); 2.4453 (1.0); 2.3319 (0.7); 2.3273 (0.9); 2.3224 (0.7); 2.3089 (1.0); 2.2999 (1.0); 2.2651 (0.8); 2.2564 (0.8); 1.8798 (0.7); 1.8621 (1.3); 1.8453 (1.8); 1.8284 (1.4); 1.8113 (0.7); 0.8430 (15.0); 0.8345 (16.0); 0.8264 (15.6); 0.8179 (15.3); 0.0080 (0.6); -0.0002 (21.1); - 0.0085 (0.8) I.5-28: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.0832 (2.5); 8.1155 (0.6); 7.4065 (1.5); 7.2678 (1.8); 7.2471 (3.4); 7.2077 (2.4); 7.2022 (2.3); 7.1870 (1.1); 7.1819 (1.2); 4.1997 (0.5); 4.1824 (1.4); 4.1655 (1.9); 4.1487 (1.4); 3.6560 (1.2); 3.6384 (1.3); 3.6304 (1.4); 3.6130 (1.3); 3.3365 (1.0); 3.3047 (224.7); 3.2026 (1.4); 3.1928 (1.6); 3.1775 (1.3); 3.1674 (1.2); 2.6863 (1.6); 2.6737 (1.7); 2.6690 (2.5); 2.6649 (3.0); 2.6443 (2.0); 2.6233 (1.6); 2.5225 (6.6); 2.5178 (9.0); 2.5092 (128.3); 2.5046 (280.3); 2.5000 (393.6); 2.4953 (276.4); 2.4908 (125.8); 2.4495 (0.6); 2.3866 (0.6); 2.3360 (0.8); 2.3314 (1.8); 2.3267 (2.4); 2.3222 (1.7); 2.2962 (1.0); 2.2840 (0.9); 2.2539 (1.0); 2.2423 (0.8); 2.1401 (16.0); 1.0737 (10.5); 1.0650 (11.0); 1.0568 (10.8); 1.0481 (11.0); - 0.0002 (1.5) I.5-29: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1654 (1.2); 7.5638 (2.8); 7.5581 (0.9); 7.5466 (0.9); 7.5408 (3.1); 7.5004 (1.0); 7.4966 (1.0); 7.4804 (1.2); 7.4767 (1.2); 7.3218 (0.8); 7.3180 (0.8); 7.3021 (0.7); 7.2982 (0.6); 7.2475 (0.5); 7.2434 (0.5); 7.2276 (0.7); 6.9592 (3.1); 6.9535 (0.9); 6.9420 (0.9); 6.9363 (2.8); 4.2074 (0.6); 4.1905 (0.8); 4.1815 (0.8); 4.1648 (0.7); 3.7431 (16.0); 3.3666 (0.5); 3.3166 (111.2); 3.2665 (1.1); 3.0034 (0.6); 2.9829 (0.7); 2.9604 (0.8); 2.9401 (0.7); 2.6698 (0.7); 2.5232 (4.2); 2.5186 (5.6); 2.5099 (37.4); 2.5053 (77.6); 2.5007 (106.7); 2.4961 (74.8); 2.4915 (33.5); 2.4600 (0.7); 2.4552 (1.0); 2.4506 (1.3); 2.4460 (0.9); 2.3275 (0.7); 1.1756 (0.8); 0.0080 (2.2); 0.0064 (0.8); 0.0056 (0.8); 0.0048 (0.9); 0.0039 (1.1); -0.0002 (65.4); -0.0058 (1.3); -0.0067 (1.1); -0.0085 (2.2); -0.0503 (0.7) I.5-31: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1527 (16.0); 8.3945 (4.1); 8.3779 (4.0); 7.6905 (2.7); 7.6739 (2.9); 7.6563 (2.1); 7.6520 (1.6); 7.6485 (1.4); 7.6399 (1.2); 7.6384 (1.3); 7.6326 (1.5); 7.5892 (0.6); 7.5828 (0.6); 7.5798 (0.6); 7.5771 (0.7); 7.5715 (1.6); 7.5660 (1.5); 7.5561 (1.1); 7.5526 (1.2); 7.5478 (1.5); 7.5371 (0.6); 7.5180 (0.5); 7.5018 (11.4); 7.4981 (11.8); 7.4819 (13.8); 7.4781 (13.9); 7.4617 (0.6); 7.4551 (0.7); 7.4495 (0.9); 7.4468 (0.8); 7.4418 (0.8); 7.4376 (1.4); 7.4280 (2.3); 7.4231 (3.0); 7.4195 (2.4); 7.4118 (4.0); 7.4069 (0.7); 7.4042 (1.6); 7.4008 (2.4); 7.3956 (1.4); 7.3820 (0.6); 7.3769 (0.5); 7.3414 (5.5); 7.3376 (5.9); 7.3226 (10.1); 7.3188 (9.6); 7.3030 (7.9); 7.2991 (7.3); 7.2495 (5.7); 7.2455 (5.8); 7.2300 (7.4); 7.2262 (7.4); 7.2111 (3.5); 7.2071 (3.3); 4.8127 (2.1); 4.5910 (0.7); 4.5733 (2.3); 4.5556 (2.4); 4.5434 (1.3); 4.5380 (0.9); 4.5204 (3.4); 4.5002 (6.5); 4.4799 (3.6); 4.4765 (3.7); 4.4563 (1.8); 4.1662 (0.5); 4.1247 (0.6); 4.1070 (0.6); 3.8105 (6.0); 3.7932 (6.6); 3.7850 (7.5); 3.7677 (6.5); 3.3716 (5.7); 3.3614 (5.7); 3.3452 (5.2); 3.3359 (5.5); 3.3222 (407.6); 3.2903 (0.7); 3.2879 (0.8); 3.2724 (3.7); 3.2226 (0.6); 3.1752 (2.1); 3.1622 (2.1); 3.1105 (0.6); 3.0983 (0.7); 3.0809 (0.6); 2.7356 (7.9); 2.7147 (8.8); 2.6933 (10.4); 2.6724 (9.6); 2.5237 (1.4); 2.5190 (2.0); 2.5102 (50.6); 2.5057 (116.5); 2.5010 (166.9); 2.4964 (118.3); 2.4918 (54.0); 2.4560 (1.7); 2.4512 (2.0); 2.4468 (1.6); 2.4062 (0.6); 2.3324 (1.0); 2.3279 (1.3); 2.3232 (1.0); 2.3186 (0.7); 2.2975 (3.2); 2.2870 (3.2); 2.2553 (2.6); 2.2449 (2.7); 2.2166 (1.6); 2.1915 (5.4); 2.1667 (9.5); 2.1634 (7.3); 2.1422 (7.6); 2.1390 (6.4); 2.1176 (2.5); 2.0732 (0.5); 2.0400 (0.6); 2.0272 (2.1); 2.0133 (4.7); 2.0048 (4.5); 2.0010 (6.4); 1.9959 (6.3); 1.9854 (6.2); 1.9805 (6.2); 1.9704 (4.2); 1.9572 (2.0); 1.9539 (2.0); 1.6691 (2.4); 1.6543 (6.5); 1.6417 (7.1); 1.6299 (12.1); 1.6157 (6.1); 1.6053 (5.7); 1.5951 (1.7); 1.5898 (2.1); 1.3404 (2.5); 1.3227 (5.5); 1.3050 (2.5); 1.2506 (0.8); 1.2329 (1.8); 1.2150 (0.8); 1.1942 (2.1); 1.1761 (4.3); 1.1578 (2.2); 1.1538 (3.2); 1.1360 (6.0); 1.1183 (2.7); -0.0002 (3.6) I.5-32: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1471 (2.6); 8.3182 (0.6); 7.8979 (2.9); 7.8924 (1.2); 7.8808 (1.9); 7.8750 (9.6); 7.8532 (9.3); 7.8475 (2.0); 7.8361 (1.2); 7.8304 (2.9); 7.4074 (2.1); 7.2666 (1.9); 7.2459 (3.8); 7.2090 (2.6); 7.2034 (2.4); 7.1883 (1.3); 7.1829 (1.3); 4.9908 (0.6); 4.2733 (1.3); 4.2561 (1.6); 4.2472 (1.7); 4.2299 (1.4); 4.0561 (1.0); 4.0383 (3.0); 4.0205 (3.1); 4.0028 (1.0); 3.8198 (1.2); 3.8115 (1.1); 3.7945 (1.0); 3.7859 (1.0); 3.3033 (56.2); 3.0832 (1.4); 3.0624 (1.6); 3.0398 (1.9); 3.0188 (1.6); 2.6737 (1.1); 2.6689 (1.4); 2.6644 (1.0); 2.6182 (1.1); 2.6082 (1.2); 2.5735 (1.0); 2.5639 (1.0); 2.5225 (4.0); 2.5178 (5.7); 2.5091 (81.5); 2.5046 (174.7); 2.5000 (242.2); 2.4954 (169.3); 2.4909 (76.2); 2.3313 (0.9); 2.3267 (1.4); 2.3223 (1.0); 2.1390 (16.0); 1.9875 (14.2); 1.2471 (1.2); 1.1923 (3.6); 1.1745 (7.3); 1.1568 (3.5); 0.8754 (0.6); 0.8584 (1.9); 0.8406 (0.6); 0.0080 (3.0); -0.0002 (96.4); -0.0085 (2.7) I.5-33: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.1803 (3.6); 8.4015 (1.0); 8.3892 (0.9); 7.7070 (0.8); 7.6865 (0.9); 7.6625 (6.1); 7.6565 (6.3); 7.4150 (4.1); 7.4089 (3.9); 7.3933 (3.5); 7.3872 (3.4); 5.7522 (1.2); 4.7987 (0.6); 4.2024 (0.7); 4.1856 (1.8); 4.1687 (2.6); 4.1517 (1.9); 4.1349 (0.7); 3.6664 (1.7); 3.6491 (1.8); 3.6408 (2.0); 3.6237 (1.8); 3.3053 (46.1); 3.2091 (1.5); 3.1995 (1.5); 3.1835 (1.4); 3.1741 (1.4); 2.7097 (2.2); 2.6888 (2.4); 2.6738 (0.6); 2.6676 (3.2); 2.6468 (2.5); 2.5227 (1.9); 2.5180 (2.7); 2.5094 (42.3); 2.5048 (93.1); 2.5002 (131.3); 2.4955 (92.3); 2.4909 (42.1); 2.4685 (0.6); 2.4637 (0.6); 2.4595 (0.6); 2.4554 (0.6); 2.4508 (0.7); 2.3316 (0.6); 2.3269 (0.8); 2.3224 (0.6); 2.2827 (0.9); 2.2715 (0.9); 2.2396 (0.8); 2.2299 (0.7); 1.0787 (14.4); 1.0655 (15.9); 1.0618 (16.0); 1.0486 (14.4); 0.0080 (2.2); -0.0002 (78.0); -0.0085 (2.5) Gegenstand der vorliegenden Erfindung ist die Verwendung mindestens eines Pyrrolidinons der allgemeinen Formel (I), in Kombination mit weiteren agrochemischen Wirkstoffen wie beispielsweise Fungizide, Insektizide, Herbizide, Pflanzenwachstumsregulatoren oder Safener, zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren, bevorzugt Trockenstress, sowie zur Stärkung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags. Weiterer Gegenstand der vorliegenden Erfindung ist eine Sprühlösung zur Behandlung von Pflanzen, enthaltend eine zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksame Menge von mindestens einer Verbindung, ausgewählt aus der Gruppe, bestehend aus mindestens einem der erfindungsgemäß substituierten Pyrrolidinone, der allgemeinen Formel (I). Zu den dabei relativierbaren abiotischen Stressbedingungen können zum Beispiel Hitze, Dürre, Kälte- und Trockenstress (Stress verursacht durch Trockenheit und/oder Wassermangel), osmotischer Stress, Staunässe, erhöhter Bodensalzgehalt, erhöhtes Ausgesetztsein an Mineralien, Ozonbedingungen, Starklichtbedingungen, beschränkte Verfügbarkeit von Stickstoffnährstoffen, beschränkte Verfügbarkeit von Phosphornährstoffen zählen. In einer Ausführungsform kann beispielsweise vorgesehen sein, dass eine oder mehrere der erfindungsgemäß zu verwendenden Verbindungen, d. h. die entsprechenden erfindungsgemäß substituierten Pyrrolidinone der allgemeinen Formel (I), durch eine Sprühapplikation auf entsprechend zu behandelnde Pflanzen oder Pflanzenteile aufgebracht werden. Die Verwendung der Verbindungen der allgemeinen Formel (I) oder deren Salze erfolgt vorzugsweise mit einer Dosierung zwischen 0,00005 und 3 kg/ha, besonders bevorzugt zwischen 0,0001 und 2 kg/ha, insbesondere bevorzugt zwischen 0,0005 und 1 kg/ha, im Speziellen bevorzugt zwischen 0,001 und 0,25 kg/ha. Unter der Bezeichnung Resistenz bzw. Widerstandsfähigkeit gegenüber abiotischem Stress werden im Rahmen der vorliegenden Erfindung verschiedenartige Vorteile für Pflanzen verstanden. Solche vorteilhaften Eigenschaften äußern sich beispielsweise in den nachfolgend genannten verbesserten Pflanzencharakteristika: verbessertes Wurzelwachstum hinsichtlich Oberfläche und Tiefe, vermehrte Ausläuferbildung oder Bestockung, stärkere und produktivere Ausläufer und Bestockungstriebe, Verbesserung des Sprosswachstums, erhöhte Standfestigkeit, vergrößerte Sprossbasisdurchmesser, vergrößerte Blattfläche, höhere Erträge an Nähr- und Inhaltsstoffen, wie z.B. Kohlenhydrate, Fette, Öle, Proteine, Vitamine, Mineralstoffe, ätherische Öle, Farbstoffe, Fasern, bessere Faserqualität, früheres Blühen, gesteigerte Blütenanzahl, reduzierter Gehalt an toxischen Produkten wie Mycotoxine, reduzierter Gehalt an Rückständen oder unvorteilhaften Bestandteilen jeglicher Art oder bessere Verdaulichkeit, verbesserte Lagerstabilität des Erntegutes, verbesserter Toleranz gegenüber unvorteilhaften Temperaturen, verbesserter Toleranz gegenüber Dürre und Trockenheit, wie auch Sauerstoffmangel durch Wasserüberschuss, verbesserte Toleranz gegenüber erhöhten Salzgehalten in Böden und Wasser, gesteigerte Toleranz gegenüber Ozonstress, verbesserte Verträglichkeit gegenüber Herbiziden und anderen Pflanzenbehandlungsmitteln, verbesserte Wasseraufnahme und Photosyntheseleistung, vorteilhafte Pflanzeneigenschaften, wie beispielsweise Beschleunigung der Reifung, gleichmäßigere Abreife, größere Anziehungskraft für Nützlinge, verbesserte Bestäubung oder andere Vorteile, die einem Fachmann durchaus bekannt sind. Insbesondere zeigt die Verwendung einer oder mehrerer erfindungsgemäßen Verbindungen der allgemeinen Formel (I) in der Sprühapplikation auf Pflanzen und Pflanzenteilen die beschriebenen Vorteile. Die kombinierte Verwendung von erfindungsgemäßen N-Sulfonyl-N‘-aryldiaminoalkanen und N-Sulfonyl-N‘-heteroaryldiaminoalkanen der allgemeinen Formel (I) mit gentechnisch veränderten Sorten in Bezug auf erhöhte abiotische Stresstoleranz ist darüber hinaus ebenfalls möglich. Die weiter oben genannten verschiedenartigen Vorteile für Pflanzen lassen sich bekannterweise partiell zusammenfassen und mit allgemein gültigen Begriffen belegen. Soche Begriffe sind beispielsweise die nachfolgend aufgeführten Bezeichnungen: phytotonischer Effekt, Widerstandsfähigkeit gegenüber Stressfaktoren, weniger Pflanzenstress, Pflanzengesundheit, gesunde Pflanzen, Pflanzenfitness, („Plant Fitness“), „Plant Wellness“, „Plant Concept“, „Vigor Effect“, „Stress Shield“, Schutzschild, „Crop Health“, „Crop Health Properties“, „Crop Health Products“, „Crop Health Management“, „Crop Health Therapy“, „Plant Health“, Plant Health Properties“, Plant Health Products“, „Plant Health Management“, „Plant Health Therapy“, Grünungseffekt („Greening Effect“ oder „Re-greening Effect“), „Freshness“ oder andere Begriffe, die einem Fachmann durchaus bekannt sind. Im Rahmen der vorliegenden Erfindung wird unter einem guten Effekt auf die Widerstandsfähigkeit gegenüber abiotischem Stress nicht beschränkend • mindestens ein um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % verbessertes Auflaufen, • mindestens einen im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % gesteigerten Ertrag, • mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % verbesserte Wurzelentwicklung, • mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % ansteigende Sprossgröße, • mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % vergrößerte Blattfläche, • mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % verbesserte Photosyntheseleistung und/oder • mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % verbesserte Blütenausbildung verstanden, wobei die Effekte einzeln oder aber in beliebiger Kombination von zwei oder mehreren Effekten auftreten können. Weiterer Gegenstand der vorliegenden Erfindung ist eine Sprühlösung zur Behandlung von Pflanzen, enthaltend eine zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksame Menge von mindestens einer Verbindung aus der Gruppe der erfindungsgemäß substituierten Pyrrolidinone der allgemeinen Formel (I). Die Sprühlösung kann andere übliche Bestandteile aufweisen, wie Lösungsmittel, Formulierhilfsstoffe, insbesondere Wasser, enthalten. Weitere Bestandteile können unter anderem agrochemische Wirkstoffe sein, welche unten noch weiter beschrieben werden. Weiterer Gegenstand der vorliegenden Erfindung ist die Verwendung von entsprechenden Sprühlösungen zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren. Die nachfolgenden Ausführungen gelten sowohl für die Verwendung einer oder mehrerer erfindungsgemäßer Verbindungen der allgemeinen Formel (I) an sich als auch für die entsprechenden Sprühlösungen. Es wurde darüber hinausgefunden, dass die Anwendung einer oder mehrerer erfindungsgemäßer Verbindungen der allgemeinen Formel (I) in Kombination mit mindestens einem Düngemittel wie weiter unten tehend definiert auf Pflanzen oder in deren Umgebung möglich ist. Düngemittel, die erfindungsgemäß zusammen mit den oben näher erläuterten erfindungsgemäßen Verbindungen der allgemeinen Formel (I) verwendet werden können, sind im Allgemeinen organische und anorganische Stickstoff-haltige Verbindungen wie beispielsweise Harnstoffe, Harnstoff- Formaldehyd-Kondensationsprodukte, Aminosäuren, Ammoniumsalze und -nitrate, Kaliumsalze (bevorzugt Chloride, Sulfate, Nitrate), Phosphorsäuresalze und/oder Salze von Phosphoriger Säure (bevorzugt Kaliumsalze und Ammoniumsalze). Insbesondere zu nennen sind in diesem Zusammenhang die NPK-Dünger, d.h. Düngemittel, die Stickstoff, Phosphor und Kalium enthalten, Kalkammonsalpeter, d.h. Düngemittel, die noch Calcium enthalten, Ammonsulfatsalpeter (Allgemeine Formel (NH4)2SO4 NH4NO3), Ammonphosphat und Ammonsulfat. Diese Düngemittel sind dem Fachmann allgemein bekannt, siehe auch beispielsweise Ullmann's Encyclopedia of Industrial Chemistry, 5. Edition, Vol. A 10, Seiten 323 bis 431, Verlagsgesellschaft, Weinheim, 1987. Die Düngemittel können auch Salze aus Mikronährstoffen (bevorzugt Calcium, Schwefel, Bor, Mangan, Magnesium, Eisen, Bor, Kupfer, Zink, Molybdän und Kobalt) und Phytohormonen (z. B. Vitamin B1 und Indol-(III)essigsäure) oder Gemische davon enthalten. Erfindungsgemäß eingesetzte Düngemittel können auch weitere Salze wie Monoammoniumphosphat (MAP), Diammoniumphosphat (DAP), Kaliumsulfat, Kaliumchlorid, Magnesiumsulfat enthalten. Geeignete Mengen für die sekundären Nährstoffe oder Spurenelemente sind Mengen von 0,5 bis 5 Gew.-%, bezogen auf das gesamte Düngemittel. Weitere mögliche Inhaltsstoffe sind Pflanzenschutzmittel, Insektizide, Fungizide, Safener oder Wachstumsregulatoren oder Gemische davon. Hierzu folgen weiter unten weitergehende Ausführungen. Die Düngemittel können beispielsweise in Form von Pulvern, Granulaten, Prills oder Kompaktaten eingesetzt werden. Die Düngemittel können jedoch auch in flüssiger Form, gelöst in einem wässrigen Medium, eingesetzt werden. In diesem Fall kann auch verdünnter wässriger Ammoniak als Stickstoffdüngemittel eingesetzt werden. Weitere mögliche Inhaltsstoffe für Düngemittel sind beispielsweise in Ullmann's Encyclopedia of Industrial Chemistry, 5. Auflage, 1987, Band A 10, Seiten 363 bis 401, DE-A 4128828, DE-A 1905834 und DE-A 19631764 beschrieben. Die allgemeine Zusammensetzung der Düngemittel, bei welchen es sich im Rahmen der vorliegenden Erfindung um Einzelnährstoff- und/oder Mehrnährstoffdünger handeln kann, beispielsweise aus Stickstoff, Kalium oder Phosphor, kann innerhalb eines breiten Bereichs variieren. Im Allgemeinen ist ein Gehalt von 1 bis 30 Gew.-% Stickstoff (bevorzugt 5 bis 20 Gew.-%), von 1 bis 20 Gew.-% Kalium (bevorzugt 3 bis 15 Gew.-%) und ein Gehalt von 1 bis 20 Gew.-% Phosphor (bevorzugt 3 bis 10 Gew.-%) vorteilhaft. Der Gehalt von Mikroelementen ist üblicherweise im ppm-Bereich, bevorzugt im Bereich von von 1 bis 1000 ppm. Im Rahmen der vorliegenden Erfindung können das Düngemittel sowie eine oder mehrere erfindungsgemäße Verbindungen der allgemeinen Formel (I) zeitgleich verabreicht werden. Es ist jedoch auch möglich, zunächst das Düngemittel und dann eine oder mehrere erfindungsgemäße Verbindungen der allgemeinen Formel (I) oder zunächst eine oder mehrere Verbindungen der allgemeinen Formel (I) und dann das Düngemittel anzuwenden. Bei nicht zeitgleicher Anwendung einer oder mehrerer Verbindungen der allgemeinen Formel (I) und des Düngemittels erfolgt im Rahmen der vorliegenden Erfindung jedoch die Anwendung in funktionellem Zusammenhang, insbesondere innerhalb eines Zeitraums von im Allgemeinen 24 Stunden, bevorzugt 18 Stunden, besonders bevorzugt 12 Stunden, speziell 6 Stunden, noch spezieller 4 Stunden, noch weiter spezieller innerhalb 2 Stunden. In ganz besonderen Ausführungsformen der vorliegenden Erfindung erfolgt die Anwendung einer oder mehrerer erfindungsgemäßer Verbindungen der Formel (I) und des Düngemittels in einem zeitlichen Rahmen von weniger als 1 Stunden, vorzugsweise weniger als 30 Minuten, besonders bevorzugt weniger als 15 Minuten. Bevorzugt ist die Verwendung von erfindungsgemäßen Verbindungen der allgemeinen Formel (I) auf Pflanzen aus der Gruppe der Nutzpflanzen, Zierpflanzen, Rasenarten, allgemein genutzte Bäume, die in öffentlichen und privaten Bereichen als Zierpflanzen Verwendungen finden, und Forstbestand. Der Forstbestand umfasst Bäume für die Herstellung von Holz, Zellstoff, Papier und Produkten die aus Teilen der Bäume hergestellt werden. Der Begriff Nutzpflanzen, wie hier verwendet, bezeichnet Kulturpflanzen, die als Pflanzen für die Gewinnung von Nahrungsmitteln, Futtermitteln, Treibstoffe oder für technische Zwecke eingesetzt werden. Zu den Nutzpflanzen zählen z. B. folgende Pflanzenarten: Triticale, Durum (Hartweizen), Turf, Reben, Getreide, beispielsweise Weizen, Gerste, Roggen, Hafer, Reis, Mais und Hirse; Rüben, beispielsweise Zuckerrüben und Futterrüben; Früchte, beispielsweise Kernobst, Steinobst und Beerenobst, beispielsweise Äpfel, Birnen, Pflaumen, Pfirsiche, Mandeln, Kirschen und Beeren, z. B. Erdbeeren, Himbeeren, Brombeeren; Hülsenfrüchte, beispielsweise Bohnen, Linsen, Erbsen und Sojabohnen; Ölkulturen, beispielsweise Raps, Senf, Mohn, Oliven, Sonnenblumen, Kokos, Castorölpflanzen, Kakaobohnen und Erdnüsse; Gurkengewächse, beispielsweise Kürbis, Gurken und Melonen; Fasergewächse, beispielsweise Baumwolle, Flachs, Hanf und Jute; Citrusfrüchte, beispielsweise Orangen, Zitronen, Pampelmusen und Mandarinen; Gemüsesorten, beispielsweise Spinat, (Kopf)-Salat, Spargel, Kohlarten, Möhren, Zwiebeln, Tomaten, Kartoffeln und Paprika; Lorbeergewächse, beispielsweise Avocado, Cinnamomum, Kampfer, oder ebenso Pflanzen wie Tabak, Nüsse, Kaffee, Aubergine, Zuckerrohr, Tee, Pfeffer, Weinreben, Hopfen, Bananen, Naturkautschukgewächse sowie Zierpflanzen, beispielsweise Blumen, Sträucher, Laubbäume und Nadelbäume wie Koniferen. Diese Aufzählung stellt keine Limitierung dar. Als besonders geeignete Zielkulturen für die Anwendung des erfindungsgemäßen Verfahrens sind folgende Pflanzen anzusehen: Hafer, Roggen, Triticale, Durum, Baumwolle, Aubergine, Turf, Kernobst, Steinobst, Beerenobst, Mais, Weizen, Gerste, Gurke, Tabak, Reben, Reis, Getreide, Birne, Pfeffer, Bohnen, Sojabohnen, Raps, Tomate, Paprika, Melonen, Kohl, Kartoffel und Apfel. Als Bäume, die entsprechend dem erfindungsgemäßen Verfahren verbessert werden können, seien beispielhaft genannt: Abies sp., Eucalyptus sp., Picea sp., Pinus sp., Aesculus sp., Platanus sp., Tilia sp., Acer sp., Tsuga sp., Fraxinus sp., Sorbus sp., Betula sp., Crataegus sp., Ulmus sp., Quercus sp., Fagus sp., Salix sp., Populus sp.. Als bevorzugte Bäume, die entsprechend dem erfindungsgemäßen Verfahren verbessert werden können, können genannt werden: Aus der Baumart Aesculus: A. hippocastanum, A. pariflora, A. carnea; aus der Baumart Platanus: P. aceriflora, P. occidentalis, P. racemosa; aus der Baumart Picea: P. abies; aus der Baumart Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. elliottii, P. montecola, P. albicaulis, P. resinosa, P. palustris, P. taeda, P. flexilis, P. jeffregi, P. baksiana, P. strobes; aus der Baumart Eucalyptus: E. grandis, E. globulus, E. camadentis, E. nitens, E. obliqua, E. regnans, E. pilularus. Als besonders bevorzugte Bäume, die entsprechend dem erfindungsgemäßen Verfahren verbessert werden können, können genannt werden: Aus der Baumart Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. strobes; aus der Baumart Eucalyptus: E. grandis, E. globulus und E. camadentis. Als besonders bevorzugte Bäume, die entsprechend dem erfindungsgemäßen Verfahren verbessert werden können, können genannt werden: Rosskastanie, Platanengewächs, Linde und Ahornbaum. Die vorliegende Erfindung kann auch an beliebigen Rasenarten („turfgrasses“) durchgeführt werden, einschließlich „cool season turfgrasses“ und „warm season turfgrasses“. Beispiele für Rasenarten für die kalte Jahreszeit sind Blaugräser („blue grasses“; Poa spp.), wie „Kentucky bluegrass“ (Poa pratensis L.), „rough bluegrass“ (Poa trivialis L.), „Canada bluegrass“ (Poa compressa L.), „annual bluegrass“ (Poa annua L.), „upland bluegrass“ (Poa glaucantha Gaudin), „wood bluegrass“ (Poa nemoralis L.) und „bulbous bluegrass“ (Poa bulbosa L.); Straussgräser („Bentgrass“, Agrostis spp.), wie „creeping bentgrass“ (Agrostis palustris Huds.), „colonial bentgrass“ (Agrostis tenuis Sibth.), „velvet bentgrass“ (Agrostis canina L.), „South German Mixed Bentgrass“ (Agrostis spp. einschließlich Agrostis tenius Sibth., Agrostis canina L., und Agrostis palustris Huds.), und „redtop“ (Agrostis alba L.); Schwingel („Fescues“, Festucu spp.), wie „red fescue“ (Festuca rubra L. spp. rubra), „creeping fescue“ (Festuca rubra L.), „chewings fescue“ (Festuca rubra commutata Gaud.), „sheep fescue“ (Festuca ovina L.), „hard fescue“ (Festuca longifolia Thuill.), „hair fescue“ (Festucu capillata Lam.), „tall fescue“ (Festuca arundinacea Schreb.) und „meadow fescue“ (Festuca elanor L.); Lolch („ryegrasses“, Lolium spp.), wie „annual ryegrass“ (Lolium multiflorum Lam.), „perennial ryegrass“ (Lolium perenne L.) und „italian ryegrass“ (Lolium multiflorum Lam.); und Weizengräser (“wheatgrasses”, Agropyron spp..), wie “fairway wheatgrass” (Agropyron cristatum (L.) Gaertn.), „crested wheatgrass“ (Agropyron desertorum (Fisch.) Schult.) und “western wheatgrass” (Agropyron smithii Rydb.). Beispiele für weitere “cool season turfgrasses” sind “beachgrass” (Ammophila breviligulata Fern.), “smooth bromegrass” (Bromus inermis Leyss.), Schilf (“cattails”) wie “Timothy” (Phleum pratense L.), “sand cattail” (Phleum subulatum L.), “orchardgrass” (Dactylis glomerata L.), “weeping alkaligrass” (Puccinellia distans (L.) Parl.) und “crested dog’s-tail” (Cynosurus cristatus L.). Beispiele für “warm season turfgrasses” sind „Bermudagrass“ (Cynodon spp. L. C. Rich), “zoysiagrass” (Zoysia spp. Willd.), „St. Augustine grass“ (Stenotaphrum secundatum Walt Kuntze), „centipedegrass“ (Eremochloa ophiuroides Munro Hack.), „carpetgrass“ (Axonopus affinis Chase), „Bahia grass“ (Paspalum notatum Flugge), „Kikuyugrass“ (Pennisetum clandestinum Hochst. ex Chiov.), „buffalo grass“ (Buchloe dactyloids (Nutt.) Engelm.), “Blue gramma” (Bouteloua gracilis (H.B.K.) Lag. ex Griffiths), „seashore paspalum“ (Paspalum vaginatum Swartz) und „sideoats grama“ (Bouteloua curtipendula (Michx. Torr.). “Cool season turfgrasses” sind für die erfindungsgemäße Verwendung im Allgemeinen bevorzugt. Besonders bevorzugt sind Blaugras, Straussgras und „redtop“, Schwingel und Lolch. Straussgras ist insbesondere bevorzugt. Besonders bevorzugt werden mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) Pflanzen der jeweils handelsüblichen oder in Gebrauch befindlichen Pflanzensorten behandelt. Unter Pflanzensorten versteht man Pflanzen mit neuen Eigenschaften ("Traits"), die sowohl durch konven- tionelle Züchtung, durch Mutagenese oder mit Hilfe rekombinanter DNA-Techniken, gezüchtet worden sind. Kulturpflanzen können demnach Pflanzen sein, die durch konventionelle Züchtungs- und Optimierungsmethoden oder durch biotechnologische und gentechnologische Methoden oder Kombinationen dieser Methoden erhalten werden können, einschließlich der transgenen Pflanzen und einschließlich der durch Sortenschutzrechte schützbaren oder nicht schützbaren Pflanzensorten. Das erfindungsgemäße Behandlungsverfahren kann somit auch für die Behandlung von genetisch modifizierten Organismen (GMOs), z. B. Pflanzen oder Samen, verwendet werden. Genetisch modifizierte Pflanzen (oder transgene Pflanzen) sind Pflanzen, bei denen ein heterologes Gen stabil in das Genom integriert worden ist. Der Begriff "heterologes Gen" bedeutet im Wesentlichen ein Gen, das außerhalb der Pflanze bereitgestellt oder assembliert wird und das bei Einführung in das Zellkerngenom, das Chloroplastengenom oder das Hypochondriengenom der transformierten Pflanze dadurch neue oder verbesserte agronomische oder sonstige Eigenschaften verleiht, dass es ein interessierendes Protein oder Polypeptid exprimiert oder dass es ein anderes Gen, das in der Pflanze vorliegt bzw. andere Gene, die in der Pflanze vorliegen, herunterreguliert oder abschaltet (zum Beispiel mittels Antisense-Technologie, Co-suppressionstechnologie oder RNAi-Technologie [RNA Interference]). Ein heterologes Gen, das im Genom vorliegt, wird ebenfalls als Transgen bezeichnet. Ein Transgen, das durch sein spezifisches Vorliegen im Pflanzengenom definiert ist, wird als Transformations- bzw. transgenes Event bezeichnet. Zu Pflanzen und Pflanzensorten, die vorzugsweise mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden, zählen alle Pflanzen, die über Erbgut verfügen, das diesen Pflanzen besonders vorteilhafte, nützliche Merkmale verleiht (egal, ob dies durch Züchtung und/oder Biotechnologie erzielt wurde). Pflanzen und Pflanzensorten, die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind solche Pflanzen, die gegen einen oder mehrere abiotische Stressfaktoren resistent sind. Zu den abiotischen Stressbedingungen können zum Beispiel Hitze, Dürre, Kälte- und Trockenstress,, osmotischer Stress, Staunässe, erhöhter Bodensalzgehalt, erhöhtes Ausgesetztsein an Mineralien, Ozonbedingungen, Starklichtbedingungen, beschränkte Verfügbarkeit von Stickstoffnährstoffen, beschränkte Verfügbarkeit von Phosphornährstoffen oder Vermeidung von Schatten zählen. Pflanzen und Pflanzensorten, die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind solche Pflanzen, die durch erhöhte Ertragseigenschaften gekennzeichnet sind. Ein erhöhter Ertrag kann bei diesen Pflanzen z. B. auf verbesserter Pflanzenphysiologie, verbessertem Pflanzenwuchs und verbesserter Pflanzenentwicklung, wie Wasserverwertungseffizienz, Wasserhalteeffizienz, verbesserter Stickstoffverwertung, erhöhter Kohlenstoffassimilation, verbesserter Photosynthese, verstärkter Keimkraft und beschleunigter Abreife beruhen. Der Ertrag kann weiterhin durch eine verbesserte Pflanzenarchitektur (unter Stress- und nicht- Stress-Bedingungen) beeinflusst werden, darunter frühe Blüte, Kontrolle der Blüte für die Produktion von Hybridsaatgut, Keimpflanzenwüchsigkeit, Pflanzengröße, Internodienzahl und -abstand, Wurzelwachstum, Samengröße, Fruchtgröße, Schotengröße, Schoten- oder Ährenzahl, Anzahl der Samen pro Schote oder Ähre, Samenmasse, verstärkte Samenfüllung, verringerter Samenausfall, verringertes Schotenplatzen sowie Standfestigkeit. Zu weiteren Ertragsmerkmalen zählen Samenzusammensetzung wie Kohlenhydratgehalt, Proteingehalt, Ölgehalt und Ölzusammensetzung, Nährwert, Verringerung der nährwidrigen Verbindungen, verbesserte Verarbeitbarkeit und verbesserte Lagerfähigkeit. Pflanzen, die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind Hybridpflanzen, die bereits die Eigenschaften der Heterosis bzw. des Hybrideffekts exprimieren, was im allgemeinen zu höherem Ertrag, höherer Wüchsigkeit, besserer Gesundheit und besserer Resistenz gegen biotische und abiotische Stressfaktoren führt. Solche Pflanzen werden typischerweise dadurch erzeugt, dass man eine ingezüchtete pollensterile Elternlinie (den weiblichen Kreuzungspartner) mit einer anderen ingezüchteten pollenfertilen Elternlinie (dem männlichen Kreuzungspartner) kreuzt. Das Hybridsaatgut wird typischerweise von den pollensterilen Pflanzen geerntet und an Vermehrer verkauft. Pollensterile Pflanzen können manchmal (z. B. beim Mais) durch Entfahnen (d. h. mechanischem Entfernen der männlichen Geschlechtsorgane bzw. der männlichen Blüten), produziert werden; es ist jedoch üblicher, dass die Pollensterilität auf genetischen Determinanten im Pflanzengenom beruht. In diesem Fall, insbesondere dann, wenn es sich bei dem gewünschten Produkt, da man von den Hybridpflanzen ernten will, um die Samen handelt, ist es üblicherweise günstig, sicherzustellen, dass die Pollenfertilität in Hybridpflanzen, die die für die Pollensterilität verantwortlichen genetischen Determinanten enthalten, völlig restoriert wird. Dies kann erreicht werden, indem sichergestellt wird, dass die männlichen Kreuzungspartner entsprechende Fertilitätsrestorergene besitzen, die in der Lage sind, die Pollenfertilität in Hybridpflanzen, die die genetischen Determinanten, die für die Pollensterilität verantwortlich sind, enthalten, zu restorieren. Genetische Determinanten für Pollensterilität können im Cytoplasma lokalisiert sein. Beispiele für cytoplasmatische Pollensterilität (CMS) wurden zum Beispiel für Brassica-Arten beschrieben (WO92/005251, WO95/009910, WO98/27806, WO2005/002324, WO2006/021972 und US6,229,072). Genetische Determinanten für Pollensterilität können jedoch auch im Zellkerngenom lokalisiert sein. Pollensterile Pflanzen können auch mit Methoden der pflanzlichen Biotechnologie, wie Gentechnik, erhalten werden. Ein besonders günstiges Mittel zur Erzeugung von pollensterilen Pflanzen ist in WO 89/10396 beschrieben, wobei zum Beispiel eine Ribonuklease wie eine Barnase selektiv in den Tapetumzellen in den Staubblättern exprimiert wird. Die Fertilität kann dann durch Expression eines Ribonukleasehemmers wie Barstar in den Tapetumzellen restoriert werden (z. B. WO91/002069). Pflanzen oder Pflanzensorten (die mit Methoden der Pflanzenbiotechnologie, wie der Gentechnik, erhalten werden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind herbizidtolerante Pflanzen, d. h. Pflanzen, die gegenüber einem oder mehreren vorgegebenen Herbiziden tolerant gemacht worden sind. Solche Pflanzen können entweder durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solch eine Herbizidtoleranz verleiht, erhalten werden. Herbizidtolerante Pflanzen sind zum Beispiel glyphosatetolerante Pflanzen, d. h. Pflanzen, die gegenüber dem Herbizid Glyphosate oder dessen Salzen tolerant gemacht worden sind. So können zum Beispiel glyphosatetolerante Pflanzen durch Transformation der Pflanze mit einem Gen, das für das Enzym 5-Enolpyruvylshikimat-3-phosphatsynthase (EPSPS) kodiert, erhalten werden. Beispiele für solche EPSPS-Gene sind das AroA-Gen (Mutante CT7) des Bakterium Salmonella typhimurium (Comai et al., Science (1983), 221, 370-371), das CP4-Gen des Bakteriums Agrobacterium sp. (Barry et al., Curr. Topics Plant Physiol. (1992), 7, 139-145), die Gene, die für eine EPSPS aus der Petunie (Shah et al., Science (1986), 233, 478-481), für eine EPSPS aus der Tomate (Gasser et al., J. Biol. Chem. (1988), 263, 4280-4289) oder für eine EPSPS aus Eleusine (WO2001/66704) kodieren. Es kann sich auch um eine mutierte EPSPS handeln, wie sie zum Beispiel in EP-A 0837944, WO2000/066746, WO2000/066747 oder WO2002/026995 beschrieben ist. Glyphosatetolerante Pflanzen können auch dadurch erhalten werden, dass man ein Gen exprimiert, das für ein Glyphosate-Oxidoreduktase-Enzym, wie es in US5,776,760 und US5,463,175 beschrieben ist, kodiert. Glyphosatetolerante Pflanzen können auch dadurch erhalten werden, dass man ein Gen exprimiert, das für ein Glyphosate-acetyltransferase- Enzym, wie es in z. B. WO2002/036782, WO2003/092360, WO2005/012515 und WO2007/024782 beschrieben ist, kodiert. Glyphosatetolerante Pflanzen können auch dadurch erhalten werden, dass man Pflanzen, die natürlich vorkommende Mutationen der oben erwähnten Gene, wie sie zum Beispiel in WO01/024615 oder WO2003/013226 beschrieben sind, enthalten, selektiert. Sonstige herbizidresistente Pflanzen sind zum Beispiel Pflanzen, die gegenüber Herbiziden, die das Enzym Glutaminsynthase hemmen, wie Bialaphos, Phosphinotricin oder Glufosinate, tolerant gemacht worden sind. Solche Pflanzen können dadurch erhalten werden, dass man ein Enzym exprimiert, das das Herbizid oder eine Mutante des Enzyms Glutaminsynthase, das gegenüber Hemmung resistent ist, entgiftet. Solch ein wirksames entgiftendes Enzym ist zum Beispiel ein Enzym, das für ein Phosphinotricin-acetyltransferase kodiert (wie zum Beispiel das bar- oder pat-Protein aus Streptomyces- Arten). Pflanzen, die eine exogene Phosphinotricin-acetyltransferase exprimieren, sind zum Beispiel in US5,561,236; US5,648,477; US5,646,024; US5,273,894; US5,637,489; US5,276,268; US5,739,082; US5,908,810 und US7,112,665 beschrieben. Weitere herbizidtolerante Pflanzen sind auch Pflanzen, die gegenüber den Herbiziden, die das Enzym Hydroxyphenylpyruvatdioxygenase (HPPD) hemmen, tolerant gemacht worden sind. Bei den Hydroxyphenylpyruvatdioxygenasen handelt es sich um Enzyme, die die Reaktion, in der para- Hydroxyphenylpyruvat (HPP) zu Homogentisat umgesetzt wird, katalysieren. Pflanzen, die gegenüber HPPD-Hemmern tolerant sind, können mit einem Gen, das für ein natürlich vorkommendes resistentes HPPD-Enzym kodiert, oder einem Gen, das für ein mutiertes HPPD-Enzym gemäß WO96/038567, WO99/024585 und WO99/024586 kodiert, transformiert werden. Eine Toleranz gegenüber HPPD- Hemmern kann auch dadurch erzielt werden, dass man Pflanzen mit Genen transformiert, die für gewisse Enzyme kodieren, die die Bildung von Homogentisat trotz Hemmung des nativen HPPD- Enzyms durch den HPPD-Hemmer ermöglichen. Solche Pflanzen und Gene sind in WO99/034008 und WO2002/36787 beschrieben. Die Toleranz von Pflanzen gegenüber HPPD-Hemmern kann auch dadurch verbessert werden, dass man Pflanzen zusätzlich zu einem Gen, das für ein HPPD-tolerantes Enzym kodiert, mit einem Gen transformiert, das für ein Prephenatdehydrogenase-Enzym kodiert, wie dies in WO2004/024928 beschrieben ist. Weitere herbizidresistente Pflanzen sind Pflanzen, die gegenüber Acetolactatsynthase (ALS)-Hemmern tolerant gemacht worden sind. Zu bekannten ALS-Hemmern zählen zum Beispiel Sulfonylharnstoff, Imidazolinon, Triazolopyrimidine, Pyrimidinyloxy(thio)benzoate und/oder Sulfonylaminocarbonyl- triazolinon-Herbizide. Es ist bekannt, dass verschiedene Mutationen im Enzym ALS (auch als Acetohydroxysäure-Synthase, AHAS, bekannt) eine Toleranz gegenüber unterschiedlichen Herbiziden bzw. Gruppen von Herbiziden verleihen, wie dies zum Beispiel bei Tranel und Wright, Weed Science (2002), 50, 700-712, jedoch auch in US5,605,011, US5,378,824, US5,141,870 und US5,013,659, beschrieben ist. Die Herstellung von sulfonylharnstofftoleranten Pflanzen und imidazolinontoleranten Pflanzen ist in US5,605,011; US5,013,659; US5,141,870; US5,767,361; US5,731,180; US5,304,732; US4,761,373; US5,331,107; US5,928,937; und US5,378,824; sowie in der internationalen Veröffentlichung WO96/033270 beschrieben. Weitere imidazolinontolerante Pflanzen sind auch in z. B. WO2004/040012, WO2004/106529, WO2005/020673, WO2005/093093, WO2006/007373, WO2006/015376, WO2006/024351 und WO2006/060634 beschrieben. Weitere sulfonylharnstoff- und imidazolinontolerante Pflanzen sind auch in z.B. WO2007/024782 beschrieben. Weitere Pflanzen, die gegenüber ALS-Inhibitoren, insbesondere gegenüber Imidazolinonen, Sulfonylharnstoffen und/oder Sulfamoylcarbonyltriazolinonen tolerant sind, können durch induzierte Mutagenese, Selektion in Zellkulturen in Gegenwart des Herbizids oder durch Mutationszüchtung erhalten werden, wie dies zum Beispiel für die Sojabohne in US5,084,082, für Reis in WO97/41218, für die Zuckerrübe in US5,773,702 und WO99/057965, für Salat in US5,198,599 oder für die Sonnenblume in WO2001/065922 beschrieben ist. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind insektenresistente transgene Pflanzen, d.h. Pflanzen, die gegen Befall mit gewissen Zielinsekten resistent gemacht wurden. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solch eine Insektenresistenz verleiht, erhalten werden. Der Begriff "insektenresistente transgene Pflanze" umfasst im vorliegenden Zusammenhang jegliche Pflanze, die mindestens ein Transgen enthält, das eine Kodiersequenz umfasst, die für folgendes kodiert: 1) ein insektizides Kristallprotein aus Bacillus thuringiensis oder einen insektiziden Teil davon, wie die insektiziden Kristallproteine, die von Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, zusammengestellt wurden, von Crickmore et al. (2005) in der Bacillus thuringiensis-Toxinnomenklatur aktualisiert (online bei: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), oder insektizide Teile davon, z.B. Proteine der Cry-Proteinklassen Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry3Ae oder Cry3Bb oder insektizide Teile davon; oder 2) ein Kristallprotein aus Bacillus thuringiensis oder einen Teil davon, der in Gegenwart eines zweiten, anderen Kristallproteins als Bacillus thuringiensis oder eines Teils davon insektizid wirkt, wie das binäre Toxin, das aus den Kristallproteinen Cy34 und Cy35 besteht (Moellenbeck et al., Nat. Biotechnol. (2001), 19, 668-72; Schnepf et al., Applied Environm. Microb. (2006), 71, 1765-1774); oder 3) ein insektizides Hybridprotein, das Teile von zwei unterschiedlichen insektiziden Kristallproteinen aus Bacillus thuringiensis umfasst, wie zum Beispiel ein Hybrid aus den Proteinen von 1) oben oder ein Hybrid aus den Proteinen von 2) oben, z. B. das Protein Cry1A.105, das von dem Mais- Event MON98034 produziert wird (WO2007/027777); oder 4) ein Protein gemäß einem der Punkte 1) bis 3) oben, in dem einige, insbesondere 1 bis 10, Aminosäuren durch eine andere Aminosäure ersetzt wurden, um eine höhere insektizide Wirksamkeit gegenüber einer Zielinsektenart zu erzielen und/oder um das Spektrum der entsprechenden Zielinsektenarten zu erweitern und/oder wegen Veränderungen, die in die Kodier- DNA während der Klonierung oder Transformation induziert wurden, wie das Protein Cry3Bb1 in Mais-Events MON863 oder MON88017 oder das Protein Cry3A im Mais-Event MIR 604; oder 5) ein insektizides sezerniertes Protein aus Bacillus thuringiensis oder Bacillus cereus oder einen insektiziden Teil davon, wie die vegetativ wirkenden insektentoxischen Proteine (vegetative insecticidal proteins, VIP), die unter folgendem Link angeführt sind, z. B. Proteine der Proteinklasse VIP3Aa: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/vip.html oder 6) ein sezerniertes Protein aus Bacillus thuringiensis oder Bacillus cereus, das in Gegenwart eines zweiten sezernierten Proteins aus Bacillus thuringiensis oder B. cereus insektizid wirkt, wie das binäre Toxin, das aus den Proteinen VIP1A und VIP2A besteht (WO94/21795); oder 7) ein insektizides Hybridprotein, das Teile von verschiedenen sezernierten Proteinen von Bacillus thuringiensis oder Bacillus cereus umfasst, wie ein Hybrid der Proteine von 1) oder ein Hybrid der Proteine von 2) oben; oder 8) ein Protein gemäß einem der Punkte 1) bis 3) oben, in dem einige, insbesondere 1 bis 10, Aminosäuren durch eine andere Aminosäure ersetzt wurden, um eine höhere insektizide Wirksamkeit gegenüber einer Zielinsektenart zu erzielen und/oder um das Spektrum der entsprechenden Zielinsektenarten zu erweitern und/oder wegen Veränderungen, die in die Kodier- DNA während der Klonierung oder Transformation induziert wurden (wobei die Kodierung für ein insektizides Protein erhalten bleibt), wie das Protein VIP3Aa im Baumwoll-Event COT 102. Natürlich zählt zu den insektenresistenten transgenen Pflanzen im vorliegenden Zusammenhang auch jegliche Pflanze, die eine Kombination von Genen umfasst, die für die Proteine von einer der oben genannten Klassen 1 bis 8 kodieren. In einer Ausführungsform enthält eine insektenresistente Pflanze mehr als ein Transgen, das für ein Protein nach einer der oben genannten 1 bis 8 kodiert, um das Spektrum der entsprechenden Zielinsektenarten zu erweitern oder um die Entwicklung einer Resistenz der Insekten gegen die Pflanzen dadurch hinauszuzögern, dass man verschiedene Proteine einsetzt, die für dieselbe Zielinsektenart insektizid sind, jedoch eine unterschiedliche Wirkungsweise, wie Bindung an unterschiedliche Rezeptorbindungsstellen im Insekt, aufweisen. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind gegenüber abiotischen Stressfaktoren tolerant. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solch eine Stressresistenz verleiht, erhalten werden. Zu besonders nützlichen Pflanzen mit Stresstoleranz zählen folgende: a. Pflanzen, die ein Transgen enthalten, das die Expression und/oder Aktivität des Gens für die Poly(ADP-ribose)polymerase (PARP) in den Pflanzenzellen oder Pflanzen zu reduzieren vermag, wie dies in WO2000/004173 oder EP04077984.5 oder EP06009836.5 beschrieben ist. b. Pflanzen, die ein stresstoleranzförderndes Transgen enthalten, das die Expression und/oder Aktivität der für PARG kodierenden Gene der Pflanzen oder Pflanzenzellen zu reduzieren vermag, wie dies z.B. in WO2004/090140 beschrieben ist; c. Pflanzen, die ein stresstoleranzförderndes Transgen enthalten, das für ein in Pflanzen funktionelles Enzym des Nicotinamidadenindinukleotid-Salvage-Biosynthesewegs kodiert, darunter Nicotinamidase, Nicotinatphosphoribosyltransferase, Nicotinsäuremononukleotid-adenyltransferase, Nicotinamidadenindinukleotidsynthetase oder Nicotinamidphosphoribosyl-transferase, wie dies z. B. in EP04077624.7 oder WO2006/133827 oder PCT/EP07/002433 beschrieben ist. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, weisen eine veränderte Menge, Qualität und/oder Lagerfähigkeit des Ernteprodukts und/oder veränderte Eigenschaften von bestimmten Bestandteilen des Ernteprodukts auf, wie zum Beispiel: 1) Transgene Pflanzen, die eine modifizierte Stärke synthetisieren, die bezüglich ihrer chemisch- physikalischen Eigenschaften, insbesondere des Amylosegehalts oder des Amylose/Amylopektin- Verhältnisses, des Verzweigungsgrads, der durchschnittlichen Kettenlänge, der Verteilung der Seitenketten, des Viskositätsverhaltens, der Gelfestigkeit, der Stärkekorngröße und/oder Stärkekornmorphologie im Vergleich mit der synthetisierten Stärke in Wildtyppflanzenzellen oder - pflanzen verändert ist, so dass sich diese modifizierte Stärke besser für bestimmte Anwendungen eignet. Diese transgenen Pflanzen, die eine modifizierte Stärke synthetisieren, sind zum Beispiel in EP0571427, WO95/004826, EP0719338, WO96/15248, WO96/19581, WO96/27674, WO97/11188, WO 97/26362, WO97/32985, WO97/42328, WO97/44472, WO97/45545, WO98/27212, WO98/40503, WO99/58688, WO99/58690, WO99/58654, WO2000/008184, WO2000/008185, WO2000/28052, WO2000/77229, WO2001/12782, WO2001/12826, WO2002/101059, WO2003/071860, WO2004/056999, WO2005/030942, WO2005/030941, WO2005/095632, WO2005/095617, WO2005/095619, WO2005/095618, WO2005/123927, WO2006/018319, WO2006/103107, WO2006/108702, WO2007/009823, WO2000/22140, WO2006/063862, WO2006/072603, WO2002/034923, EP06090134.5, EP06090228.5, EP06090227.7, EP07090007.1, EP07090009.7, WO2001/14569, WO2002/79410, WO2003/33540, WO2004/078983, WO2001/19975, WO95/26407, WO96/34968, WO98/20145, WO99/12950, WO99/66050, WO99/53072, US6,734,341, WO2000/11192, WO98/22604, WO98/32326, WO2001/98509, WO2001/98509, WO2005/002359, US5,824,790, US6,013,861, WO94/004693, WO94/009144, WO94/11520, WO95/35026 bzw. WO97/20936 beschrieben. 2) Transgene Pflanzen, die Nichtstärkekohlenhydratpolymere synthetisieren, oder Nichtstärkekohlenhydratpolymere, deren Eigenschaften im Vergleich zu Wildtyppflanzen ohne genetische Modifikation verändert sind. Beispiele sind Pflanzen, die Polyfructose, insbesondere des Inulin- und Levantyps, produzieren, wie dies in EP0663956, WO96/001904, WO96/021023, WO98/039460 und WO99/024593 beschrieben ist, Pflanzen, die alpha-1,4-Glucane produzieren, wie dies in WO95/031553, US2002/031826, US6,284,479, US5,712,107, WO97/047806, WO97/047807, WO97/047808 und WO2000/14249 beschrieben ist, Pflanzen, die alpha-1,6-verzweigte alpha-1,4- Glucane produzieren, wie dies in WO2000/73422 beschrieben ist, und Pflanzen, die Alternan produzieren, wie dies in WO2000/047727, EP06077301.7, US5,908,975 und EP0728213 beschrieben ist. 3) Transgene Pflanzen, die Hyaluronan produzieren, wie dies zum Beispiel in WO06/032538, WO2007/039314, WO2007/039315, WO2007/039316, JP2006/304779 und WO2005/012529 beschrieben ist. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind Pflanzen wie Baumwollpflanzen mit veränderten Fasereigenschaften. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solche veränderten Fasereigenschaften verleiht, erhalten werden; dazu zählen: a) Pflanzen wie Baumwollpflanzen, die eine veränderte Form von Cellulosesynthasegenen enthalten, wie dies in WO98/000549 beschrieben ist, b) Pflanzen wie Baumwollpflanzen, die eine veränderte Form von rsw2- oder rsw3-homologen Nukleinsäuren enthalten, wie dies in WO2004/053219 beschrieben ist; c) Pflanzen wie Baumwollpflanzen mit einer erhöhten Expression der Saccharosephosphatsynthase, wie dies in WO2001/017333 beschrieben ist; d) Pflanzen wie Baumwollpflanzen mit einer erhöhten Expression der Saccharosesynthase, wie dies in WO2002/45485 beschrieben ist; e) Pflanzen wie Baumwollpflanzen bei denen der Zeitpunkt der Durchlasssteuerung der Plasmodesmen an der Basis der Faserzelle verändert ist, z. B. durch Herunterregulieren der faserselektiven β-1,3-Glucanase, wie dies in WO2005/017157 beschrieben ist; f) Pflanzen wie Baumwollpflanzen mit Fasern mit veränderter Reaktivität, z. B. durch Expression des N-Acetylglucosamintransferasegens, darunter auch nodC, und von Chitinsynthasegenen, wie dies in WO2006/136351 beschrieben ist. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind Pflanzen wie Raps oder verwandte Brassica-Pflanzen mit veränderten Eigenschaften der Ölzusammensetzung. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solche veränderten Öleigenschaften verleiht, erhalten werden; dazu zählen: a) Pflanzen wie Rapspflanzen, die Öl mit einem hohen Ölsäuregehalt produzieren, wie dies zum Beispiel in US5,969,169, US5,840,946 oder US6,323,392 oder US6,063, 947 beschrieben ist; b) Pflanzen wie Rapspflanzen, die Öl mit einem niedrigen Linolensäuregehalt produzieren, wie dies in US6,270828, US6,169,190 oder US5,965,755 beschrieben ist. c) Pflanzen wie Rapspflanzen, die Öl mit einem niedrigen gesättigten Fettsäuregehalt produzieren, wie dies z. B. in US5,434,283 beschrieben ist. Besonders nützliche transgene Pflanzen, die mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind Pflanzen, die Transformations-Events, oder eine Kombination von Transformations-Events, enthalten und die zum Beispiel in den Dateien von verschiedenen nationalen oder regionalen Behörden angeführt sind. Besonders nützliche transgene Pflanzen, die mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind beispielhaft Pflanzen mit einem oder mehreren Genen, die für ein oder mehrere Toxine kodieren, sind die transgenen Pflanzen, die unter den folgenden Handelsbezeichnungen angeboten werden: YIELD GARD ^ (zum Beispiel Mais, Baumwolle, Sojabohnen), KnockOut ^ (zum Beispiel Mais), BiteGard ^ (zum Beispiel Mais), BT-Xtra ^ (zum Beispiel Mais), StarLink ^ (zum Beispiel Mais), Bollgard ^ (Baumwolle), Nucotn ^ (Baumwolle), Nucotn 33B ^ (Baumwolle), NatureGard ^ (zum Beispiel Mais), Protecta ^ und NewLeaf ^ (Kartoffel). Herbizidtolerante Pflanzen, die zu erwähnen sind, sind zum Beispiel Maissorten, Baumwollsorten und Sojabohnensorten, die unter den folgenden Handelsbezeichnungen angeboten werden: Roundup Ready ^ (Glyphosatetoleranz, zum Beispiel Mais, Baumwolle, Sojabohne), Liberty Link ^ (Phosphinotricintoleranz, zum Beispiel Raps), IMI ^ (Imidazolinontoleranz) und SCS ^ (Sylfonylharnstofftoleranz), zum Beispiel Mais. Zu den herbizidresistenten Pflanzen (traditionell auf Herbizidtoleranz gezüchtete Pflanzen), die zu erwähnen sind, zählen die unter der Bezeichnung Clearfield ^ angebotenen Sorten (zum Beispiel Mais). Die erfindungsgemäß zu verwendenden Verbindungen der Formel (I) können in übliche Formulierungen überführt werden, wie Lösungen, Emulsionen, Spritzpulver, wasser- und ölbasierte Suspensionen, Pulver, Stäubemittel, Pasten, lösliche Pulver, lösliche Granulate, Streugranulate, Suspensions- Emulsions-Konzentrate, Wirkstoff-imprägnierte Naturstoffe, Wirkstoff-imprägnierte synthetische Stoffe, Düngemittel sowie Feinstverkapselungen in polymeren Stoffen. Im Rahmen der vorliegenden Erfindung ist es insbesondere bevorzugt, wenn die Verbindungen der allgemeinen Formel (I) in der Form einer Sprühformulieruing verwendet werden. Die vorliegende Erfindung betrifft daher darüber hinaus auch eine Sprühformulierung zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischem Stress. Im Folgenden wird eine Sprühformulierung näher beschrieben: Die Formulierungen zur Sprühapplikation werden in bekannter Weise hergestellt, z.B. durch Ver- mischen der zu verwendenden erfindungsgemäßen Verbindungen der allgmeinen Formel (I) mit Streckmitteln, also flüssigen Lösungsmitteln und/oder festen Trägerstoffen, gegebenenfalls unter Verwendung von oberflächenaktiven Mitteln, also Emulgiermitteln und/oder Dispergiermitteln und/oder schaumerzeugenden Mitteln. Weitere übliche Zusatzstoffe, wie zum Beispiel übliche Streckmittel sowie Lösungs- oder Verdünnungsmittel, Farbstoffe, Netzmittel, Dispergiermittel, Emulgatoren, Entschäumer, Konservierungsmittel, sekundäre Verdickungsmittel, Kleber, Gibberelline und auch Wasser, können gegebenenfalls auch verwendet werden. Die Herstellung der Formulierungen erfolgt entweder in geeigneten Anlagen oder auch vor oder während der Anwendung. Als Hilfsstoffe können solche Stoffe Verwendung finden, die geeignet sind, dem Mittel selbst oder und/oder davon abgeleitete Zubereitungen (z.B. Spritzbrühen) besondere Eigenschaften zu verleihen, wie bestimmte technische Eigenschaften und/oder auch besondere biologische Eigenschaften. Als typische Hilfsmittel kommen in Frage: Streckmittel, Lösemittel und Trägerstoffe. Als Streckmittel eignen sich z.B. Wasser, polare und unpolare organische chemische Flüssigkeiten z.B. aus den Klassen der aromatischen und nicht-aromatischen Kohlenwasserstoffe (wie Paraffine, Alkylbenzole, Alkylnaphthaline, Chlorbenzole), der Alkohole und Polyole (die ggf. auch substituiert, verethert und/oder verestert sein können), der Ketone (wie Aceton, Cyclohexanon), Ester (auch Fette und Öle) und (Poly-)Ether, der einfachen und substituierten Amine, Amide, Lactame (wie N- Alkylpyrrolidone) und Lactone, der Sulfone und Sulfoxide (wie Dimethylsysulfoxid). Im Falle der Benutzung von Wasser als Streckmittel können z.B. auch organische Lösemittel als Hilfslösungsmittel verwendet werden. Als flüssige Lösemittel kommen im wesentlichen in Frage: Aromaten, wie Xylol, Toluol, oder Alkylnaphthaline, chlorierte Aromaten und chlorierte aliphatische Kohlenwasserstoffe, wie Chlorbenzole, Chlorethylene oder Methylenchlorid, aliphatische Kohlen- wasserstoffe, wie Cyclohexan oder Paraffine, z.B. Erdölfraktionen, mineralische und pflanzliche Öle, Alkohole, wie Butanol oder Glykol sowie deren Ether und Ester, Ketone wie Aceton, Methylethylketon, Methylisobutylketon oder Cyclohexanon, stark polare Lösungsmittel, wie Dimethylsulfoxid, sowie Wasser. Es können Farbstoffe wie anorganische Pigmente, z.B. Eisenoxid, Titanoxid, Ferrocyanblau und organische Farbstoffe, wie Alizarin-, Azo- und Metallphthalocyaninfarbstoffe und Spurennährstoffe wie Salze von Eisen, Mangan, Bor, Kupfer, Kobalt, Molybdän und Zink verwendet werden. Als Netzmittel, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen alle zur Formulierung von agrochemischen Wirkstoffen üblichen, die Benetzung fördernden Stoffe in Frage. Vorzugsweise verwendbar sind Alkylnaphthalin-Sulfonate, wie Diisopropyl- oder Diisobutylnaphthalin-Sulfonate. Als Dispergiermittel und/oder Emulgatoren, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen alle zur Formulierung von agrochemischen Wirkstoffen üblichen nichtionischen, anionischen und kationischen Dispergiermittel in Betracht. Vorzugsweise verwendbar sind nichtionische oder anionische Dispergiermittel oder Gemische von nichtionischen oder anionischen Dispergiermitteln. Als geeignete nichtionische Dispergiermittel sind insbesondere Ethylenoxid- Propylenoxid-Blockpolymere, Alkylphenolpolyglykolether sowie Tristryrylphenolpolyglykolether und deren phosphatierte oder sulfatierte Derivate zu nennen. Geeignete anionische Dispergiermittel sind insbesondere Ligninsulfonate, Polyacrylsäuresalze und Arylsulfonat-Formaldehydkondensate. Als Entschäumer können in den erfindungsgemäß verwendbaren Formulierungen alle zur Formulierung von agrochemischen Wirkstoffen üblichen schaumhemmenden Stoffe enthalten sein. Vorzugsweise verwendbar sind Silikonentschäumer und Magnesiumstearat. Als Konservierungsmittel können in den erfindungsgemäß verwendbaren Formulierungen alle für derartige Zwecke in agrochemischen Mitteln einsetzbaren Stoffe vorhanden sein. Beispielhaft genannt seien Dichlorphen und Benzylalkoholhemiformal. Als sekundäre Verdickungsmittel, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen alle für derartige Zwecke in agrochemischen Mitteln einsetzbaren Stoffe in Frage. Vorzugsweise in Betracht kommen Cellulosederivate, Acrylsäurederivate, Xanthan, modifizierte Tone und hochdisperse Kieselsäure. Als Kleber, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen alle üblichen in Beizmitteln einsetzbaren Bindemittel in Frage. Vorzugsweise genannt seien Polyvinylpyrrolidon, Polyvinylacetat, Polyvinylalkohol und Tylose. Als Gibberelline, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen vorzugsweise die Gibberelline A1, A3 (= Gibberellinsäure), A4 und A7 infrage, besonders bevorzugt verwendet man die Gibberellinsäure. Die Gibberelline sind bekannt (vgl. R. Wegler „Chemie der Pflanzenschutz- und Schädlingsbekämpfungsmittel“, Bd.2, Springer Verlag, 1970, S.401-412). Weitere Additive können Duftstoffe, mineralische oder vegetabilische gegebenenfalls modifizierte Öle, Wachse und Nährstoffe (auch Spurennährstoffe), wie Salze von Eisen, Mangan, Bor, Kupfer, Kobalt, Molybdän und Zink sein. Weiterhin enthalten sein können Stabilisatoren wie Kältestabilisatoren, Oxidationsschutzmittel, Lichtschutzmittel oder andere die chemische und / oder physikalische Stabilität verbessernde Mittel. Die Formulierungen enthalten im Allgemeinen zwischen 0,01 und 98 Gew.-%, vorzugsweise zwischen 0,5 und 90 GEw. %, der Verbindung der allgemeinen Formel (I). Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) können in handelsüblichen Formulierungen sowie in den aus diesen Formulierungen bereiteten Anwendungsformen in Mischung mit anderen Wirkstoffen wie Insektiziden, Lockstoffen, Sterilantien, Bakteriziden, Akariziden, Nematiziden, Fungiziden, wachstumsregulierenden Stoffen, Herbiziden, Safenern, Düngemitteln oder Semiochemicals vorliegen. Ferner lässt sich die beschriebene positive Wirkung der Verbindungen der Formel (I) auf die pflanzeneigenen Abwehrkräfte durch eine zusätzliche Behandlung mit insektziden, fungiziden oder bakteriziden Wirkstoffen unterstützen. Bevorzugte Zeitpunkte für die Applikation der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) oder deren Salze zur Steigerung der Resistenz gegenüber abiotischem Stress sind Boden-, Stamm- und/oder Blattbehandlungen mit den zugelassenen Aufwandmengen. Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) oder deren Salze können im Allgemeinen darüber hinaus in ihren handelsüblichen Formulierungen sowie in den aus diesen Formulierungen bereiteten Anwendungsformen in Mischungen mit anderen Wirkstoffen, wie Insektiziden, Lockstoffen, Sterilantien, Akariziden, Nematiziden, Fungiziden, Bakteriziden, wachstumsregulierenden Stoffen, die Pflanzenreife beeinflussenden Stoffen, Safenern oder Herbiziden vorliegen. Die Wirkstoffe der allgemeinen Formel (I) können im Allgemeinen darüber hinaus in ihren handelsüblichen Formulierungen sowie in den aus diesen Formulierungen bereiteten Anwendungsformen in Mischungen mit anderen Wirkstoffen, wie Insektiziden, Lockstoffen, Sterilantien, Akariziden, Nematiziden, Fungiziden, Bakteriziden, wachstumsregulierenden Stoffen, die Pflanzenreife beeinflussenden Stoffen, Safenern oder Herbiziden vorliegen. Besonders günstige Mischpartner sind beispielsweise die nachfolgend gruppenweise genannten Wirkstoffe der verschiedenen Klassen, ohne dass durch deren Reihenfolge eine Präferenz gesetzt wird: Fungizide: F1) Inhibitoren der Nucleinsäure Synthese, z. B. Benalaxyl, Benalaxyl-M, Bupirimat, Chiralaxyl, Clozylacon, Dimethirimol, Ethirimol, Furalaxyl, Hymexazol, Metalaxyl, Metalaxyl-M, Ofurace, Oxadixyl, Oxolinsäure; F2) Inhibitoren der Mitose und Zellteilung, z. B. Benomyl, Carbendazim, Diethofencarb, Fuberidazole, Fluopicolid, Pencycuron, Thiabendazol, Thiophanat-methyl, Zoxamid und Chlor-7-(4-methylpiperidin- 1-yl)-6-(2,4,6- Trifluorphenyl [1,2,4]triazolo[1,5-a]pyrimidin; F3) Inhibitoren der Atmungskette Komplex I / II, z. B. Diflumetorim, Bixafen, Boscalid, Carboxin, Diflumethorim Fenfuram, Fluopyram, Flutolanil, Furametpyr, Mepronil, Oxycarboxin, Penflufen, Penthiopyrad, Thifluzamid, N-[2-(1,3-Dimethylbutyl)phenyl]-5-fluor-1,3-dimethyl-1H-pyrazol-4- carboxamid, Isopyrazam, Sedaxan, 3-(Difluormethyl)-1-methyl-N-(3',4',5'-trifluorbiphenyl-2-yl)-1H- pyrazol-4-carboxamid, 3-(Difluormethyl)-1-methyl-N-[2-(1,1,2,2-tetrafluorethoxy)phenyl]-1H-pyrazol- 4-carboxamid, 3-(Difluormethyl)-N-[4-fluor-2-(1,1,2,3,3,3-hexafluorpropoxy)phenyl]-1-methyl-1H- pyrazol-4-carboxamid, N-[1-(2,4-Dichlorphenyl)-1-methoxypropan-2-yl]-3-(difluormethyl)-1-methyl- 1H-pyrazol-4-carboxamid und entsprechende Salze; F4) Inhibitoren der Atmungskette Komplex III, z. B.Amisulbrom, Azoxystrobin, Cyazofamid, Dimoxystrobin, Enestrobin, Famoxadon, Fenamidon, Fluoxastrobin, Kresoximmethyl, Metominostrobin, Orysastrobin, Pyraclostrobin, Pyribencarb, Picoxystrobin, Trifloxystrobin, (2E)-2-(2- {[6-(3-Chlor-2-methylphenoxy)-5-fluorpyrimidin-4-yl]oxy}phenyl)-2-(methoxyimino)-N- methylethanamid, (2E)-2-(Ethoxyimino)-N-methyl-2-(2-{[({(1E)-1-[3-(trifluormethyl)- phenyl]ethyliden}amino)oxy]methyl}phenyl)ethanamid und entsprechende Salze, (2E)-2- (Methoxyimino)-N-methyl-2-{2-[(E)-({1-[3-(trifluormethyl)phenyl]ethoxy}- imino)methyl]phenyl}ethanamid, (2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-Fluor-2-phenylethenyl]- oxy}phenyl)ethyliden]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylethanamid, (2E)-2-{2- [({[(2E,3E)-4-(2,6-Dichlorphenyl)but-3-en-2-yliden]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N- methylethanamid, 2-Chlor-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)pyridin-3-carboxamid, 5- Methoxy-2-methyl-4-(2-{[({(1E)-1-[3-(trifluormethyl)phenyl]ethyliden}amino)oxy]methyl}phenyl)- 2,4-dihydro-3H-1,2,4-triazol-3-on, 2-Methyl-{2-[({cyclopropyl[(4-methoxyphenyl)- imino]methyl}sulfanyl)methyl]phenyl}-3-methoxyacrylat, N-(3-Ethyl-3,5,5-trimethylcyclohexyl)-3- (formylamino)-2-hydroxybenzamid und entsprechende Salze; F5) Entkoppler, z. B. Dinocap, Fluazinam; F6) Inhibitoren der ATP Produktion, z. B. Fentinacetat, Fentinchlorid, Fentinhydroxid, Silthiofam F7) Inhibitoren der Aminosäure- und Proteinbiosynthese, z.B. Andoprim, Blasticidin-S, Cyprodinil, Kasugamycin, Kasugamycinhydrochlorid Hydrat, Mepanipyrim, Pyrimethanil F8) Inhibitoren der Signal-Transduktion, z. B. Fenpiclonil, Fludioxonil, Quinoxyfen F9) Inhibitoren der Fett- und Membran Synthese, z. B. Chlozolinat, Iprodion, Procymidon, Vinclozolin, Ampropylfos, Kalium-Ampropylfos, Edifenphos, Iprobenfos (IBP), Isoprothiolan, Pyrazophos, Tolclofos-methyl, Biphenyl, Iodocarb, Propamocarb, Propamocarb hydrochlorid F10) Inhibitoren der Ergosterol Biosynthese, z. B. Fenhexamid, Azaconazol, Bitertanol, Bromuconazol, Diclobutrazol, Difenoconazol, Diniconazol, Diniconazol-M, Etaconazol, Fenbuconazol, Fluquinconazol, Flusilazol, Flutriafol, Furconazol, Furconazol-cis, Hexaconazol, Imibenconazol, Ipconazol, Metconazol, Myclobutanil, Paclobutrazol, Penconazol, Propiconazol, Prothioconazol, Simeconazol, Spiroxamin, Tebuconazol, Triadimefon, Triadimenol, Triticonazol, Uniconazol, Voriconazol, Imazalil, Imazalilsulfat, Oxpoconazol, Fenarimol, Flurprimidol, Nuarimol, Pyrifenox, Triforin, Pefurazoat, Prochloraz, Triflumizol, Viniconazol, Aldimorph, Dodemorph, Dodemorphacetat, Fenpropimorph, Tridemorph, Fenpropidin, Naftifin, Pyributicarb, Terbinafin, 1-(4-Chlorphenyl)-2-(1H- 1,2,4-triazol-1-yl)cycloheptanol, Methyl-1-(2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-1H-imidazol-5- carboxylat, N'-{5-(Difluormethyl)-2-methyl-4-[3-(trimethyl-silyl)propoxy]phenyl}-N-ethyl-N- methylimidoformamid, N-Ethyl-N-methyl-N'-{2-methyl-5-(trifluormethyl)-4-[3- (trimethylsilyl)propoxy]phenyl}imidoformamid und O-{1-[(4-Methoxy-phenoxy)methyl]-2,2- dimethylpropyl}-1H-imidazol-1-carbothioat; F11) Inhibitoren der Zellwand Synthese, z. B. Benthiavalicarb, Bialaphos, Dimethomorph, Flumorph, Iprovalicarb, Polyoxins, Polyoxorim, Validamycin A F12) Inhibitoren der Melanin Biosynthese, z. B. Capropamid, Diclocymet, Fenoxanil, Phtalid, Pyroquilon, Tricyclazol F13) Resistenzinduktion, z. B. Acibenzolar-S-methyl, Probenazol, Tiadinil F14) Multisite, z. B. Captafol, Captan, Chlorthalonil, Kupfersalze wie: Kupferhydroxid, Kupfernaphthenat, Kupferoxychlorid, Kupfersulfat, Kupferoxid, Oxin-Kupfer und Bordeaux Mischung, Dichlofluanid, Dithianon, Dodin, Dodin freie Base, Ferbam, Folpet, Fluorfolpet, Guazatin, Guazatinacetat, Iminoctadin, Iminoctadinalbesilat, Iminoctadintriacetat, Mankupfer, Mancozeb, Maneb, Metiram, Metiram Zink, Propineb, Schwefel und Schwefelpräparate enthaltend Calciumpolysulphid, Thiram, Tolylfluanid, Zineb, Ziram F15) Unbekannter Mechanismus, z. B. Amibromdol, Benthiazol, Bethoxazin, Capsimycin, Carvon, Chinomethionat, Chlorpicrin, Cufraneb, Cyflufenamid, Cymoxanil, Dazomet, Debacarb, Diclomezine, Dichlorphen, Dicloran, Difenzoquat, Difenzoquat Methylsulphat, Diphenylamin, Ethaboxam, Ferimzon, flumetover, Flusulfamid, Fluopicolid, Fluorimid, Fosatyl-Al, Hexachlorbenzol, 8-Hydroxy- chinolinsulfat, Iprodione, Irumamycin, Isotianil, Methasulphocarb, Metrafenon, Methyl Isothiocyanat, Mildiomycin, Natamycin, Nickel dimethyldithiocarbamat, Nitrothal-isopropyl, Octhilinon, Oxamocarb, Oxyfenthiin, Pentachlorphenol und Salze, 2-Phenylphenol und Salze, Piperalin, Propanosin –Natrium, Proquinazid, Pyrrolnitrin, Quintozen, Tecloftalam, Tecnazen, Triazoxid, Trichlamid, Zarilamid und 2,3,5,6-Tetrachlor-4-(methylsulfonyl)-pyridin, N-(4-Chlor-2-nitrophenyl)-N-ethyl-4-methyl- benzenesulfonamid, 2-Amino-4-methyl-N-phenyl-5-thiazolecarboxamid, 2-Chlor-N-(2,3-dihydro-1,1,3- trimethyl-1H-inden-4-yl)-3-pyridincarboxamid, 3-[5-(4-Chlorphenyl)-2,3-dimethylisoxazolidin-3- yl]pyridin, cis-1-(4-Chlorphenyl)-2-(1H-1,2,4-triazol-1-yl)-cycloheptanol, 2,4-Dihydro-5-methoxy-2- methyl-4-[[[[1-[3-(trifluormethyl)-phenyl]-ethyliden]-amino]-oxy]-methyl]-phenyl]-3H-1,2,3-triazol-3- on (185336-79-2), Methyl 1-(2,3-dihydro-2,2-dimethyl-1H-inden-1-yl)-1H-imidazole-5-carboxylat, 3,4,5-Trichlor-2,6-pyridindicarbonitril, Methyl 2-[[[cyclopropyl[(4-methoxyphenyl) imino]methyl]thio]methyl]-.alpha.-(methoxymethylen)- benzacetat, 4-Chlor-alpha-propinyloxy-N-[2-[3- methoxy-4-(2-propinyloxy)phenyl]ethyl]-benzacetamide, (2S)-N-[2-[4-[[3-(4-chlorphenyl)-2- propinyl]oxy]-3-methoxyphenyl]ethyl]-3-methyl-2-[(methylsulfonyl)amino]-butanamid, 5-Chlor-7-(4- methylpiperidin-1-yl)-6-(2,4,6-trifluorphenyl)[1,2,4]triazolo[1,5-a]pyrimidin, 5-Chlor-6-(2,4,6- trifluorphenyl)-N-[(1R)-1,2,2-trimethylpropyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amin, 5-Chlor-N-[(1R)- 1,2-dimethylpropyl]-6-(2,4,6-trifluorphenyl) [1,2,4]triazolo[1,5-a]pyrimidin-7-amine, N-[1-(5-Brom-3- chlorpyridin-2-yl)ethyl]-2,4-dichlornicotinamid, N-(5-Brom-3-chlorpyridin-2-yl)methyl-2,4-dichlor- nicotinamid, 2-Butoxy-6-iod-3-propyl-benzopyranon-4-on, N-{(Z)-[(cyclopropylmethoxy) imino][6- (difluormethoxy)-2,3-difluorphenyl]methyl}-2-benzacetamid, N-(3-Ethyl-3,5,5-trimethyl-cyclohexyl)-3- formylamino-2-hydroxy-benzamid, 2-[[[[1-[3(1Fluor-2-phenylethyl)oxy] phenyl] ethyliden]amino]oxy]methyl]-alpha-(methoxyimino)-N-methyl-alphaE-benzacetamid, N-{2-[3-Chlor-5- (trifluormethyl)pyridin-2-yl]ethyl}-2-(trifluormethyl)benzamid, N-(3',4'-dichlor-5-fluorbiphenyl-2-yl)-3- (difluormethyl)-1-methyl-1H-pyrazol-4-carboxamid, N-(6-Methoxy-3-pyridinyl)-cyclopropan carboxamid, 1-[(4-Methoxyphenoxy)methyl]-2,2-dimethylpropyl-1H-imidazol-1- carbonsäure, O-[1-[(4- Methoxyphenoxy)methyl]-2,2-dimethylpropyl]-1H-imidazol- 1- carbothioic acid, 2-(2-{[6-(3-Chlor-2- methylphenoxy)-5-fluorpyrimidin-4-yl]oxy}phenyl)-2-(methoxyimino)-N-methylacetamid Bakterizide: Bronopol, Dichlorphen, Nitrapyrin, Nickel-Dimethyldithiocarbamat, Kasugamycin, Octhilinon, Furancarbonsäure, Oxytetracyclin, Probenazol, Streptomycin, Tecloftalam, Kupfersulfat und andere Kupfer-Zubereitungen. Insektizide / Akarizide / Nematizide: Die hier mit ihrem „common name“ genannten Wirkstoffe sind bekannt und beispielsweise im Pestizidhandbuch („The Pesticide Manual“ 14th Ed., British Crop Protection Council 2006) beschrieben oder im Internet recherchierbar (z.B. http://www.alanwood.net/pesticides). (1) Acetylcholinesterase (AChE) Inhibitoren, wie beispielsweise Carbamate, z.B. Alanycarb, Aldicarb, Bendiocarb, Benfuracarb, Butocarboxim, Butoxycarboxim, Carbaryl, Carbofuran, Carbosulfan, Ethiofencarb, Fenobucarb, Formetanate, Furathiocarb, Isoprocarb, Methiocarb, Methomyl, Metolcarb, Oxamyl, Pirimicarb, Propoxur, Thiodicarb, Thiofanox, Triazamate, Trimethacarb, XMC und Xylylcarb oder organophosphate, z.B. Acephate, Azamethiphos, Azinphos-ethyl, Azinphos-methyl, Cadusafos, Chlorethoxyfos, Chlorfenvinphos, Chlormephos, Chlorpyrifos, Chlorpyrifos-methyl, Coumaphos, Cyanophos, Demeton-S-methyl, Diazinon, Dichlorvos/DDVP, Dicrotophos, Dimethoate, Dimethylvinphos, Disulfoton, EPN, Ethion, Ethoprophos, Famphur, Fenamiphos, Fenitrothion, Fenthion, Fosthiazate, Heptenophos, Imicyafos, Isofenphos, Isopropyl O-(methoxyaminothio- phosphoryl) salicylat, Isoxathion, Malathion, Mecarbam, Methamidophos, Methidathion, Mevinphos, Monocrotophos, Naled, Omethoate, Oxydemeton-methyl, Parathion, Parathion-methyl, Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidon, Phoxim, Pirimiphos-methyl, Profenofos, Propetamphos, Prothiofos, Pyraclofos, Pyridaphenthion, Quinalphos, Sulfotep, Tebupirimfos, Temephos, Terbufos, Tetrachlorvinphos, Thiometon, Triazophos, Triclorfon und Vamidothion. (2) GABA-gesteuerte Chlorid-Kanal-Antagonisten, wie beispielsweise Cyclodien-organochlorine, z.B. Chlordane und Endosulfan oder Phenylpyrazole (Fiprole), z.B. Ethiprole und Fipronil. (3) Natrium-Kanal-Modulatoren / Spannungsabhängige Natrium-Kanal-Blocker, wie beispielsweise Pyrethroide, z.B. Acrinathrin, Allethrin, d-cis-trans Allethrin, d-trans Allethrin, Bifenthrin, Bioallethrin, Bioallethrin S-cyclopentenyl Isomer, Bioresmethrin, Cycloprothrin, Cyfluthrin, beta-Cyfluthrin, Cyhalothrin, lambda-Cyhalothrin, gamma-Cyhalothrin, Cypermethrin, alpha-Cypermethrin, beta- Cypermethrin, theta-Cypermethrin, zeta-Cypermethrin, Cyphenothrin [(1R)-trans-Isomere], Deltamethrin, Empenthrin [(EZ)-(1R)-Isomere), Esfenvalerate, Etofenprox, Fenpropathrin, Fenvalerate, Flucythrinate, Flumethrin, tau-Fluvalinate, Halfenprox, Imiprothrin, Kadethrin, Momfluorthrin, Permethrin, Phenothrin [(1R)-trans-Isomer), Prallethrin, Pyrethrine (pyrethrum), Resmethrin, Silafluofen, Tefluthrin, Tetramethrin, Tetramethrin [(1R)- Isomere)], Tralomethrin und Transfluthrin oder DDT oder Methoxychlor. (4) Nikotinerge Acetylcholin-Rezeptor (nAChR) Agonisten, wie beispielsweise Neonikotinoide, z.B. Acetamiprid, Clothianidin, Dinotefuran, Imidacloprid, Nitenpyram, Thiacloprid und Thiamethoxam oder Nikotin oder Sulfoxaflor oder Flupyradifurone. (5) Nikotinerge Acetylcholin-Rezeptor (nAChR) allosterische Aktivatoren, wie beispielsweise Spinosine, z.B. Spinetoram und Spinosad. (6) Chlorid-Kanal-Aktivatoren, wie beispielsweise Avermectine/Milbemycine, z.B. Abamectin, Emamectin-benzoat, Lepimectin und Milbemectin. (7) Juvenilhormon-Imitatoren, wie beispielsweise Juvenilhormon-Analoge, z.B. Hydroprene, Kinoprene und Methoprene oder Fenoxycarb oder Pyriproxyfen. (8) Wirkstoffe mit unbekannten oder nicht spezifischen Wirkmechanismen, wie beispielsweise Alkylhalide, z.B. Methylbromid und andere Alkylhalide; oderChlorpicrin oder Sulfurylfluorid oder Borax oder Brechweinstein. (9) Selektive Fraßhemmer, z.B. Pymetrozine oder Flonicamid. (10) Milbenwachstumsinhibitoren, z.B. Clofentezine, Hexythiazox und Diflovidazin oder Etoxazole. (11) Mikrobielle Disruptoren der Insektendarmmembran, z.B. Bacillus thuringiensis Subspezies israelensis, Bacillus sphaericus, Bacillus thuringiensis Subspezies aizawai, Bacillus thuringiensis Subspezies kurstaki, Bacillus thuringiensis Subspezies tenebrionis und BT Pflanzenproteine: Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, Cry34/35Ab1. (12) Inhibitoren der oxidativen Phosphorylierung, ATP-Disruptoren, wie beispielsweise Diafenthiuron oder organozinnverbindungen, z.B. Azocyclotin, Cyhexatin und Fenbutatin-oxid oder Propargite oder Tetradifon. (13) Entkoppler der oxidativen Phoshorylierung durch Unterbrechung des H-Protongradienten, wie beispielsweise Chlorfenapyr, DNOC und Sulfluramid. (14) Nikotinerge Acetylcholin-Rezeptor-Antagonisten, wie beispielsweise Bensultap, Cartap- hydrochlorid, Thiocyclam und Thiosultap-Natrium. (15) Inhibitoren der Chitinbiosynthese, Typ 0, wie beispielsweise Bistrifluron, Chlorfluazuron, Diflubenzuron, Flucycloxuron, Flufenoxuron, Hexaflumuron, Lufenuron, Novaluron, Noviflumuron, Teflubenzuron und Triflumuron. (16) Inhibitoren der Chitinbiosynthese, Typ 1, wie beispielsweise Buprofezin. (17) Häutungsstörende Wirkstoffe, Dipteran, wie beispielsweise Cyromazine. (18) Ecdyson-Rezeptor Agonisten, wie beispielsweise Chromafenozide, Halofenozide, Methoxyfenozide und Tebufenozide. (19) Oktopaminerge Agonisten, wie beispielsweise Amitraz. (20) Komplex-III-Elektronentransportinhibitoren, wie beispielsweise Hydramethylnon oder Acequinocyl oder Fluacrypyrim. (21) Komplex-I-Elektronentransportinhibitoren, beispielsweise METI-Akarizide, z.B. Fenazaquin, Fenpyroximate, Pyrimidifen, Pyridaben, Tebufenpyrad und Tolfenpyrad oder Rotenone (Derris). (22) Spannungsabhängige Natriumkanal-Blocker, z.B. Indoxacarb oder Metaflumizone. (23) Inhibitoren der Acetyl-CoA-Carboxylase, wie beispielsweise Tetron- und Tetramsäurederivate, z.B. Spirobudiclofen, Spirodiclofen, Spiromesifen und Spirotetramat. (24) Komplex-IV-Elektronentransportinhibitoren, wie beispielsweise Phosphine, z.B. Aluminiumphosphid, Calciumphosphid, Phosphin und Zinkphosphid oder Cyanid. (25) Komplex-II-Elektronentransportinhibitoren, wie beispielsweise Cyenopyrafen und Cyflumetofen. (28) Ryanodinrezeptor-Effektoren, wie beispielsweise Diamide, z.B. Chlorantraniliprole, Cyantraniliprole, Flubendiamide und Tetrachlorantraniliprole. Weitere Wirkstoffe mit unbekanntem oder nicht eindeutigem Wirkmechanismus, wie beispielsweise Afidopyropen, Afoxolaner, Azadirachtin, Benclothiaz, Benzoximate, Bifenazate, Broflanilide, Bromopropylate, Chinomethionat, Cryolite, Cyclaniliprole, Cycloxaprid, Cyhalodiamide Dicloromezotiaz, Dicofol, Diflovidazin, Flometoquin, Fluazaindolizine, Fluensulfone, Flufenerim, Flufenoxystrobin, Flufiprole, Fluhexafon, Fluopyram, Fluralaner, Fluxametamide, Fufenozide, Guadipyr, Heptafluthrin, Imidaclothiz, Iprodione, Lotilaner, Meperfluthrin, Paichongding, Pyflubumide, Pyridalyl, Pyrifluquinazon, Pyriminostrobin, Sarolaner, Tetramethylfluthrin, Tetraniliprole, Tetrachlorantraniliprole, Tioxazafen, Thiofluoximate, Triflumezopyrim und Iodmethane; des weiteren Präparate auf Basis von Bacillus firmus (I-1582, BioNeem, Votivo) , sowie folgende bekannte wirksame Verbindungen: 1-{2-Fluor-4-methyl-5-[(2,2,2-trifluorethyl)sulfinyl]phenyl}-3-(trifluormethyl)-1H- 1,2,4-triazol-5-amin (bekannt aus WO2006/043635), {1'-[(2E)-3-(4-Chlorphenyl)prop-2-en-1-yl]-5- fluorspiro[indol-3,4'-piperidin]-1(2H)-yl}(2-chlorpyridin-4-yl)methanon (bekannt aus WO2003/106457), 2-Chlor-N-[2-{1-[(2E)-3-(4-chlorphenyl)prop-2-en-1-yl]piperidin-4-yl}-4- (trifluormethyl)phenyl]isonicotinamid (bekannt aus WO2006/003494), 3-(2,5-Dimethylphenyl)-4- hydroxy-8-methoxy-1,8-diazaspiro[4.5]dec-3-en-2-on (bekannt aus WO2009/049851), 3-(2,5- Dimethylphenyl)-8-methoxy-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl-ethylcarbonat (bekannt aus WO2009/049851), 4-(But-2-in-1-yloxy)-6-(3,5-dimethylpiperidin-1-yl)-5-fluorpyrimidin (bekannt aus WO2004/099160), 4-(But-2-in-1-yloxy)-6-(3-chlorphenyl)pyrimidin (bekannt aus WO2003/076415), PF1364 (CAS-Reg.No.1204776-60-2), Methyl-2-[2-({[3-brom-1-(3-chlorpyridin-2-yl)-1H-pyrazol-5- yl]carbonyl}amino)-5-chlor-3-methylbenzoyl]-2-methylhydrazincarboxylat (bekannt aus WO2005/085216), Methyl-2-[2-({[3-brom-1-(3-chlorpyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)-5- cyan-3-methylbenzoyl]-2-ethylhydrazincarboxylat (bekannt aus WO2005/085216), Methyl-2-[2-({[3- brom-1-(3-chlorpyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)-5-cyan-3-methylbenzoyl]-2- methylhydrazincarboxylat (bekannt aus WO2005/085216), Methyl-2-[3,5-dibrom-2-({[3-brom-1-(3- chlorpyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)benzoyl]-2-ethylhydrazincarboxylat (bekannt aus WO2005/085216), N-[2-(5-Amino-1,3,4-thiadiazol-2-yl)-4-chlor-6-methylphenyl]-3-brom-1-(3- chlorpyridin-2-yl)-1H-pyrazol-5-carboxamid (bekannt aus CN102057925), 4-[5-(3,5-Dichlorphenyl)-5- (trifluormethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methyl-N-(1-oxidothietan-3-yl)benzamid (bekannt aus WO2009/080250), N-[(2E)-1-[(6-Chlorpyridin-3-yl)methyl]pyridin-2(1H)-yliden]-2,2,2- trifluoracetamid (bekannt aus WO2012/029672), 1-[(2-Chlor-1,3-thiazol-5-yl)methyl]-4-oxo-3-phenyl- 4H-pyrido[1,2-a]pyrimidin-1-ium-2-olat (bekannt aus WO2009/099929), 1-[(6-Chlorpyridin-3- yl)methyl]-4-oxo-3-phenyl-4H-pyrido[1,2-a]pyrimidin-1-ium-2-olat (bekannt aus WO2009/099929), 4- (3-{2,6-Dichlor-4-[(3,3-dichlorprop-2-en-1-yl)oxy]phenoxy}propoxy)-2-methoxy-6- (trifluormethyl)pyrimidin (bekannt aus CN101337940), N-[2-(tert-Butylcarbamoyl)-4-chlor-6- methylphenyl]-1-(3-chlorpyridin-2-yl)-3-(fluormethoxy)-1H-pyrazol-5-carboxamid (bekannt aus WO2008/134969), Butyl-[2-(2,4-dichlorphenyl)-3-oxo-4-oxaspiro[4.5]dec-1-en-1-yl]-carbonat (bekannt aus CN 102060818), 3E)-3-[1-[(6-Chlor-3-pyridyl)methyl]-2-pyridyliden]-1,1,1-trifluor-propan-2-on (bekannt aus WO2013/144213), N-(Methylsulfonyl)-6-[2-(pyridin-3-yl)-1,3-thiazol-5-yl]pyridin-2- carboxamid (bekannt aus WO2012/000896), N-[3-(Benzylcarbamoyl)-4-chlorphenyl]-1-methyl-3- (pentafluorethyl)-4-(trifluormethyl)-1H-pyrazol-5-carboxamid (bekannt aus WO2010/051926), 5-Brom- 4-chlor-N-[4-chlor-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chlor-2-pyridyl)pyrazole-3-carboxamid (bekannt aus CN103232431), Tioxazafen, 4-[5-(3,5-Dichlorphenyl)-4,5-dihydro-5-(trifluormethyl)-3- isoxazolyl]-2-methyl-N-(cis-1-oxido-3-thietanyl)-benzamid, 4-[5-(3,5-Dichlorphenyl)-4,5-dihydro-5- (trifluormethyl)-3-isoxazolyl]-2-methyl-N-(trans-1-oxido-3-thietanyl)-benzamid und 4-[(5S)-5-(3,5- Dichlorphenyl)-4,5-dihydro-5-(trifluormethyl)-3-isoxazolyl]-2-methyl-N-(cis-1-oxido-3-thietanyl) benzamid (bekannt aus WO 2013050317 A1), N-[3-Chlor-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3- [(3,3,3-trifluorpropyl)sulfinyl]-propanamid, (+)-N-[3-Chlor-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl- 3-[(3,3,3-trifluorpropyl)sulfinyl]-propanamid und (-)-N-[3-Chlor-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N- ethyl-3-[(3,3,3-trifluorpropyl)sulfinyl]-propanamid (bekannt aus WO 2013162715 A2, WO 2013162716 A2, US 20140213448 A1), 5-[[(2E)-3-Chlor-2-propen-1-yl]amino]-1-[2,6-dichlor-4- (trifluormethyl)phenyl]-4-[(trifluormethyl)sulfinyl]-1H-pyrazol-3-carbonitril (bekannt aus CN 101337937 A), 3-Brom-N-[4-chlor-2-methyl-6-[(methylamino)thioxomethyl]phenyl]-1-(3-chlor-2- pyridinyl)-1H-pyrazol-5-carboxamid, (Liudaibenjiaxuanan, bekannt aus CN 103109816 A); N-[4- Chlor-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chlor-2-pyridinyl)-3- (fluormethoxy)-1H-pyrazol-5-carboxamid (bekannt aus WO 2012034403 A1), N-[2-(5-Amino-1,3,4- thiadiazol-2-yl)-4-chlor-6-methylphenyl]-3-brom-1-(3-chlor-2-pyridinyl)-1H-pyrazol-5-carboxamid (bekannt aus WO 2011085575 A1), 4-[3-[2,6-Dichlor-4-[(3,3-dichlor-2-propen-1-yl)oxy]phenoxy] propoxy]-2-methoxy-6-(trifluormethyl)-pyrimidin (bekannt aus CN 101337940 A); (2E)- und 2(Z)-2-[2- (4-Cyanophenyl)-1-[3-(trifluormethyl)phenyl]ethylidene]-N-[4-(difluormethoxy)phenyl]-hydrazine- carboxamid (bekannt aus CN 101715774 A); 3-(2,2-Dichlorethenyl)-2,2-dimethyl-4-(1H-benzimidazol- 2-yl)phenyl-cyclopropan-carbonsäureester (bekannt aus CN 103524422 A); (4aS)-7-Chlor-2,5-dihydro- 2-[[(methoxycarbonyl)[4-[(trifluormethyl)thio]phenyl]amino]carbonyl]-indeno[1,2-e][1,3,4]oxadiazine- 4a(3H)-carbosäuremethylester (bekannt aus CN 102391261 A). Safener sind vorzugsweise ausgewählt aus der Gruppe bestehend aus: S1) Verbindungen der Formel (S1),
Figure imgf000422_0001
wobei die Symbole und Indizes folgende Bedeutungen haben: nA ist eine natürliche Zahl von 0 bis 5, vorzugsweise 0 bis 3; RA1 ist Halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, Nitro oder (C1-C4)-Haloalkyl; -
Figure imgf000422_0002
WA ist ein unsubstituierter oder substituierter divalenter heterocyclischer Rest aus der Gruppe der teilungesättigten oder aromatischen Fünfring-Heterocyclen mit 1 bis 3 Heteroringatomen aus der Gruppe N und O, wobei mindestens ein N-Atom und höchstens ein O-Atom im Ring enthalten ist, vorzugsweise ein Rest aus der Gruppe (WA1) bis (WA4), mA ist 0 oder 1; RA2 ist ORA3, SRA3 oder NRA3RA4 oder ein gesättigter oder ungesättigter 3- bis 7-gliedriger Heterocyclus mit mindestens einem N-Atom und bis zu 3 Heteroatomen, vorzugsweise aus der Gruppe O und S, der über das N-Atom mit der Carbonylgruppe in (S1) verbunden ist und unsubstituiert oder durch Reste aus der Gruppe (C1-C4)-Alkyl, (C1-C4)-Alkoxy oder gegebenenfalls substituiertes Phenyl substituiert ist, vorzugsweise ein Rest der Formel ORA3, NHRA4 oder N(CH3)2, insbesondere der Formel OR A 3; RA 3 ist Wasserstoff oder ein unsubstituierter oder substituierter aliphatischer Kohlenwasserstoffrest, vorzugsweise mit insgesamt 1 bis 18 C-Atomen; RA 4 ist Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Alkoxy oder substituiertes oder unsubstituiertes Phenyl; RA 5 ist H, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C1-C4)-Alkoxy(C1-C8)-Alkyl, Cyano oder COORA 9, worin RA 9 Wasserstoff, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C1-C4)-Alkoxy-(C1-C4)-alkyl, (C1-C6)-Hydroxyalkyl, (C3-C12)-Cycloalkyl oder Tri-(C1-C4)-alkyl-silyl ist; RA 6, RA 7, RA 8 sind gleich oder verschieden Wasserstoff, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C3-C12)-Cycloalkyl oder substituiertes oder unsubstituiertes Phenyl; vorzugsweise: a) Verbindungen vom Typ der Dichlorphenylpyrazolin-3-carbonsäure (S1a), vorzugsweise Verbindungen wie 1-(2,4-Dichlorphenyl)-5-(ethoxycarbonyl)-5-methyl- 2-pyrazolin-3-carbonsäure, 1-(2,4-Dichlorphenyl)-5-(ethoxycarbonyl)-5-methyl-2-pyrazolin-3-carbonsäureethylester (S1-1) ("Mefenpyr-diethyl"), und verwandte Verbindungen, wie sie in der WO-A-91/07874 beschrieben sind; b) Derivate der Dichlorphenylpyrazolcarbonsäure (S1b), vorzugsweise Verbindungen wie 1-(2,4-Dichlorphenyl)-5-methyl-pyrazol-3-carbonsäureethylester (S1-2), 1-(2,4-Di- chlorphenyl)-5-isopropyl-pyrazol-3-carbonsäureethylester (S1-3), 1-(2,4-Dichlor- phenyl)-5-(1,1-dimethyl-ethyl)pyrazol-3-carbonsäureethyl-ester (S1-4) und verwandte Verbindungen, wie sie in EP-A-333131 und EP-A-269806 beschrieben sind; c) Derivate der 1,5-Diphenylpyrazol-3-carbonsäure (S1c), vorzugsweise Verbindungen wie 1-(2,4-Dichlorphenyl)-5-phenylpyrazol-3-carbonsäureethylester (S1-5), 1-(2-Chlorphenyl)-5-phenylpyrazol-3-carbonsäuremethylester (S1-6) und verwandte Verbindungen wie sie beispielsweise in der EP-A-268554 beschrieben sind; d) Verbindungen vom Typ der Triazolcarbonsäuren (S1d), vorzugsweise Verbindungen wie Fenchlorazol(-ethylester), d.h.1-(2,4-Dichlorphenyl)-5-trichlormethyl-(1H)-1,2,4-triazol-3-carbonsäure- ethylester (S1-7), und verwandte Verbindungen wie sie in EP-A-174562 und EP-A-346620 beschrieben sind; e) Verbindungen vom Typ der 5-Benzyl- oder 5-Phenyl-2-isoxazolin-3- carbonsäure oder der 5,5- Diphenyl-2-isoxazolin-3-carbonsäure (S1e), vorzugsweise Verbindungen wie 5-(2,4-Dichlorbenzyl)-2-isoxazolin-3-carbonsäureethylester (S1-8) oder 5-Phenyl-2-isoxazolin-3- carbonsäureethylester (S1-9) und verwandte Verbindungen, wie sie in WO-A-91/08202 beschrieben sind, bzw.5,5-Diphenyl-2-isoxazolin-3-carbonsäure (S1-10) oder 5,5-Diphenyl-2-isoxazolin-3- carbonsäureethylester (S1-11) ("Isoxadifen-ethyl") oder -n-propylester (S1-12) oder der 5-(4-Fluorphenyl)-5-phenyl-2-isoxazolin-3-carbonsäureethylester (S1-13), wie sie in der Patentanmeldung WO-A-95/07897 beschrieben sind. S2) Chinolinderivate der Formel (S2),
Figure imgf000423_0001
wobei die Symbole und Indizes folgende Bedeutungen haben: RB1 ist Halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, Nitro oder (C1-C4)-Haloalkyl; nB ist eine natürliche Zahl von 0 bis 5, vorzugsweise 0 bis 3; RB2 ist ORB3, SRB3 oder NRB3RB4 oder ein gesättigter oder ungesättigter 3- bis 7-gliedriger Heterocyclus mit mindestens einem N-Atom und bis zu 3 Heteroatomen, vorzugsweise aus der Gruppe O und S, der über das N-Atom mit der Carbonylgruppe in (S2) verbunden ist und unsubstituiert oder durch Reste aus der Gruppe (C1-C4)-Alkyl, (C1-C4)-Alkoxy oder gegebenenfalls substituiertes Phenyl substituiert ist, vorzugsweise ein Rest der Formel ORB 3, NHRB 4 oder N(CH3)2, insbesondere der Formel ORB 3; RB 3 ist Wasserstoff oder ein unsubstituierter oder substituierter aliphatischer Kohlenwasserstoffrest, vorzugsweise mit insgesamt 1 bis 18 C-Atomen; RB4 ist Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Alkoxy oder substituiertes oder unsubstituiertes Phenyl; TB ist eine (C1 oder C2)-Alkandiylkette, die unsubstituiert oder mit einem oder zwei (C1-C4)- Alkylresten oder mit [(C1-C3)-Alkoxy]-carbonyl substituiert ist; vorzugsweise: a) Verbindungen vom Typ der 8-Chinolinoxyessigsäure (S2a), vorzugsweise (5-Chlor-8-chinolinoxy)essigsäure-(1-methylhexyl)ester ("Cloquintocet-mexyl") (S2-1), (5-Chlor-8- chinolinoxy)essigsäure-(1,3-dimethyl-but-1-yl)ester (S2-2), (5-Chlor-8-chinolinoxy)essigsäure-4-allyloxy-butylester (S2-3), (5-Chlor-8-chinolin-oxy)essigsäure-1- allyloxy-prop-2-ylester (S2-4), (5-Chlor-8-chinolinoxy)essigsäure-ethylester (S2-5), (5-Chlor-8- chinolinoxy)essigsäuremethylester (S2-6), (5-Chlor-8-chinolinoxy)essigsäureallylester (S2-7), (5-Chlor- 8-chinolinoxy)essigsäure-2-(2-propyliden-iminoxy)-1-ethylester (S2-8), (5-Chlor-8- chinolinoxy)essigsäure-2-oxo-prop-1-ylester (S2-9) und verwandte Verbindungen, wie sie in EP-A-86750, EP-A-94349 und EP-A-191736 oder EP-A-0492366 beschrieben sind, sowie (5-Chlor- 8-chinolinoxy)essigsäure (S2-10), deren Hydrate und Salze, beispielsweise deren Lithium-, Natrium- Kalium-, Kalzium-, Magnesium-, Aluminium-, Eisen-, Ammonium-, quartäre Ammonium-, Sulfonium-, oder Phosphoniumsalze wie sie in der WO-A-2002/34048 beschrieben sind; b) Verbindungen vom Typ der (5-Chlor-8-chinolinoxy)malonsäure (S2b), vorzugsweise Verbindungen wie (5-Chlor-8-chinolinoxy)malonsäurediethylester, (5-Chlor- 8-chinolinoxy)malonsäurediallylester, (5-Chlor-8-chinolinoxy)malonsäure-methyl-ethylester und verwandte Verbindungen, wie sie in EP-A-0582198 beschrieben sind. S3) Verbindungen der Formel (S3)
Figure imgf000424_0001
wobei die Symbole und Indizes folgende Bedeutungen haben: RC 1 ist (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C2-C4)-Alkenyl, (C2-C4)-Haloalkenyl, (C3-C7)-Cycloalkyl, vorzugsweise Dichlormethyl; RC 2, RC 3 sind gleich oder verschieden Wasserstoff, (C1-C4)-Alkyl, (C2-C4)-Alkenyl, (C2-C4)-Alkinyl, (C1-C4)-Haloalkyl, (C2-C4)-Haloalkenyl, (C1-C4)-Alkylcarbamoyl-(C1-C4)-alkyl, (C2- C4)-Alkenylcarbamoyl-(C1-C4)-alkyl, (C1-C4)-Alkoxy-(C1-C4)-alkyl, Dioxolanyl-(C1-C4)-alkyl, Thiazolyl, Furyl, Furylalkyl, Thienyl, Piperidyl, substituiertes oder unsubstituiertes Phenyl, oder RC 2 und RC 3 bilden zusammen einen substituierten oder unsubstituierten heterocyclischen Ring, vorzugsweise einen Oxazolidin-, Thiazolidin-, Piperidin-, Morpholin-, Hexahydropyrimidin- oder Benzoxazinring; vorzugsweise: Wirkstoffe vom Typ der Dichloracetamide, die häufig als Vorauflaufsafener (bodenwirksame Safener) angewendet werden, wie z. B. "Dichlormid" (N,N-Diallyl-2,2-dichloracetamid) (S3-1), "R-29148" (3-Dichloracetyl-2,2,5- trimethyl-1,3-oxazolidin) der Firma Stauffer (S3-2), "R-28725" (3-Dichloracetyl-2,2,-dimethyl- 1,3-oxazolidin) der Firma Stauffer (S3-3), "Benoxacor" (4-Dichloracetyl-3,4-dihydro-3-methyl- 2H-1,4-benzoxazin) (S3-4), "PPG-1292" (N-Allyl-N-[(1,3-dioxolan-2-yl)-methyl]- dichloracetamid) der Firma PPG Industries (S3-5), "DKA-24" (N-Allyl-N- [(allylaminocarbonyl)methyl]-dichloracetamid) der Firma Sagro-Chem (S3-6), "AD-67" oder "MON 4660" (3-Dichloracetyl-1-oxa-3-aza-spiro[4,5]decan) der Firma Nitrokemia bzw. Monsanto (S3-7), "TI-35" (1-Dichloracetyl-azepan) der Firma TRI-Chemical RT (S3-8), "Diclonon" (Dicyclonon) oder "BAS145138" oder "LAB145138" (S3-9) ((RS)-1-Dichloracetyl- 3,3,8a-trimethylperhydropyrrolo[1,2-a]pyrimidin-6-on) der Firma BASF, "Furilazol" oder "MON 13900" ((RS)-3-Dichloracetyl-5-(2-furyl)-2,2-dimethyloxazolidin) (S3-10); sowie dessen (R)-Isomer (S3-11). S4) N-Acylsulfonamide der Formel (S4) und ihre Salze,
Figure imgf000425_0001
worin die Symbole und Indizes folgende Bedeutungen haben: XD ist CH oder N; RD1 ist CO-NRD5RD6 oder NHCO-RD7; RD2 ist Halogen, (C1-C4)-Haloalkyl, (C1-C4)-Haloalkoxy, Nitro, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, (C1-C4)-Alkylsulfonyl, (C1-C4)-Alkoxycarbonyl oder (C1-C4)-Alkylcarbonyl; RD 3 ist Wasserstoff, (C1-C4)-Alkyl, (C2-C4)-Alkenyl oder (C2-C4)-Alkinyl; RD 4 ist Halogen, Nitro, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Haloalkoxy, (C3-C6)-Cycloalkyl, Phenyl, (C1-C4)-Alkoxy, Cyano, (C1-C4)-Alkylthio, (C1-C4)-Alkylsulfinyl, (C1-C4)- Alkylsulfonyl, (C1-C4)-Alkoxycarbonyl oder (C1-C4)-Alkylcarbonyl; RD 5 ist Wasserstoff, (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C5-C6)-Cycloalkenyl, Phenyl oder 3- bis 6-gliedriges Heterocyclyl enthaltend vD Heteroatome aus der Gruppe Stickstoff, Sauerstoff und Schwefel, wobei die sieben letztgenannten Reste durch vD Substituenten aus der Gruppe Halogen, (C1-C6)-Alkoxy, (C1-C6)-Haloalkoxy, (C1-C2)- Alkylsulfinyl, (C1-C2)-Alkylsulfonyl, (C3-C6)-Cycloalkyl, (C1-C4)-Alkoxycarbonyl, (C1-C4)- Alkylcarbonyl und Phenyl und im Falle cyclischer Reste auch (C1-C4)-Alkyl und (C1-C4)- Haloalkyl substituiert sind; RD6 ist Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl oder (C2-C6)-Alkinyl, wobei die drei letztgenannten Reste durch vD Reste aus der Gruppe Halogen, Hydroxy, (C1-C4)-Alkyl, (C1-C4)- Alkoxy und (C1-C4)-Alkylthio substituiert sind, oder RD5 und RD6 gemeinsam mit dem dem sie tragenden Stickstoffatom einen Pyrrolidinyl- oder Piperidinyl- Rest bilden; RD7 ist Wasserstoff, (C1-C4)-Alkylamino, Di-(C1-C4)-alkylamino, (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, wobei die 2 letztgenannten Reste durch vD Substituenten aus der Gruppe Halogen, (C1-C4)- Alkoxy, (C1-C6)-Haloalkoxy und (C1-C4)-Alkylthio und im Falle cyclischer Reste auch (C1-C4)- Alkyl und (C1-C4)-Haloalkyl substituiert sind; nD ist 0, 1 oder 2; mD ist 1 oder 2; vD ist 0, 1, 2 oder 3; davon bevorzugt sind Verbindungen vom Typ der N-Acylsulfonamide, z.B. der nachfolgenden Formel (S4a), die z. B. bekannt sind aus WO-A-97/45016
Figure imgf000426_0001
worin RD7 (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, wobei die 2 letztgenannten Reste durch vD Substituenten aus der Gruppe Halogen, (C1-C4)-Alkoxy, (C1-C6)-Haloalkoxy und (C1-C4)-Alkylthio und im Falle cyclischer Reste auch (C1-C4)-Alkyl und (C1-C4)-Haloalkyl substituiert sind; RD4 Halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, CF3; mD 1 oder 2; vD ist 0, 1, 2 oder 3 bedeutet; sowie Acylsulfamoylbenzoesäureamide, z.B. der nachfolgenden Formel (S4b), die z.B. bekannt sind aus WO-A-99/16744,
Figure imgf000427_0001
z.B. solche worin RD 5 = Cyclopropyl und (RD 4) = 2-OMe ist ("Cyprosulfamide", S4-1), RD 5 = Cyclopropyl und (RD 4) = 5-Cl-2-OMe ist (S4-2), RD 5 = Ethyl und (RD 4) = 2-OMe ist (S4-3), RD 5 = Isopropyl und (RD 4) = 5-Cl-2-OMe ist (S4-4) und RD 5 = Isopropyl und (RD 4) = 2-OMe ist (S4-5). sowie Verbindungen vom Typ der N-Acylsulfamoylphenylharnstoffe der Formel (S4c), die z.B. bekannt sind aus der EP-A-365484,
Figure imgf000427_0002
worin RD 8 und RD 9 unabhängig voneinander Wasserstoff, (C1-C8)-Alkyl, (C3-C8)-Cycloalkyl, (C3-C6)-Alkenyl, (C3-C6)-Alkinyl, RD 4 Halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, CF3 mD 1 oder 2 bedeutet; beispielsweise 1-[4-(N-2-Methoxybenzoylsulfamoyl)phenyl]-3-methylharnstoff, 1-[4-(N-2-Methoxybenzoylsulfamoyl)phenyl]-3,3-dimethylharnstoff, 1-[4-(N-4,5-Dimethylbenzoylsulfamoyl)phenyl]-3-methylharnstoff. S5) Wirkstoffe aus der Klasse der Hydroxyaromaten und der aromatisch-aliphatischen Carbonsäurederivate (S5), z.B.3,4,5-Triacetoxybenzoesäureethylester, 3,5-Di-methoxy-4- hydroxybenzoesäure, 3,5-Dihydroxybenzoesäure, 4-Hydroxysalicylsäure, 4-Fluorsalicyclsäure, 2- Hydroxyzimtsäure, 2,4-Dichlorzimtsäure, wie sie in der WO-A-2004/084631, WO-A-2005/015994, WO-A-2005/016001 beschrieben sind. S6) Wirkstoffe aus der Klasse der 1,2-Dihydrochinoxalin-2-one (S6), z.B. 1-Methyl-3-(2-thienyl)-1,2-dihydrochinoxalin-2-on, 1-Methyl-3-(2-thienyl)-1,2-dihydrochinoxalin-2- thion, 1-(2-Aminoethyl)-3-(2-thienyl)-1,2-dihydro-chinoxalin-2-on-hydrochlorid, 1-(2- Methylsulfonylaminoethyl)-3-(2-thienyl)-1,2-dihydrochinoxa-lin-2-on, wie sie in der WO-A- 2005/112630 beschrieben sind. S7) Verbindungen der Formel (S7), wie sie in der WO-A-1998/38856 beschrieben sind
Figure imgf000428_0001
worin die Symbole und Indizes folgende Bedeutungen haben: RE 1, RE 2 sind unabhängig voneinander Halogen, (C1-C4)-Alkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkyl, (C1-C4)-Alkylamino, Di-(C1-C4)-Alkylamino, Nitro; AE ist COORE3 oder COSRE4 RE3, RE4 sind unabhängig voneinander Wasserstoff, (C1-C4)-Alkyl, (C2-C6)-Alkenyl, (C2-C4)-Alkinyl, Cyanoalkyl, (C1-C4)-Haloalkyl, Phenyl, Nitrophenyl, Benzyl, Halobenzyl, Pyridinylalkyl und Alkylammonium, nE1 ist 0 oder 1 nE2, nE3 sind unabhängig voneinander 0, 1 oder 2, vorzugsweise Diphenylmethoxyessigsäure, Diphenylmethoxyessigsäureethylester, Diphenyl- methoxyessigsäuremethylester (CAS-Reg.Nr.41858-19-9) (S7-1). S8) Verbindungen der Formel (S8),wie sie in der WO-A-98/27049 beschrieben sind Worin
Figure imgf000428_0002
XF CH oder N, nF für den Fall, dass XF=N ist, eine ganze Zahl von 0 bis 4 und für den Fall, dass XF=CH ist, eine ganze Zahl von 0 bis 5 , RF 1 Halogen, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy, Nitro, (C1-C4)-Alkylthio, (C1-C4)-Alkylsulfonyl, (C1-C4)-Alkoxycarbonyl, ggf. substituiertes. Phenyl, ggf. substituiertes Phenoxy, RF2 Wasserstoff oder (C1-C4)-Alkyl RF3 Wasserstoff, (C1-C8)-Alkyl, (C2-C4)-Alkenyl, (C2-C4)-Alkinyl, oder Aryl, wobei jeder der vorgenannten C-haltigen Reste unsubstituiert oder durch einen oder mehrere, vorzugsweise bis zu drei gleiche oder verschiedene Reste aus der Gruppe, bestehend aus Halogen und Alkoxy substituiert ist; bedeuten, oder deren Salze, vorzugsweise Verbindungen worin XF CH, nF eine ganze Zahl von 0 bis 2, RF1 Halogen, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy, RF2 Wasserstoff oder (C1-C4)-Alkyl, RF3 Wasserstoff, (C1-C8)-Alkyl, (C2-C4)-Alkenyl, (C2-C4)-Alkinyl, oder Aryl, wobei jeder der vorgenannten C-haltigen Reste unsubstituiert oder durch einen oder mehrere, vorzugsweise bis zu drei gleiche oder verschiedene Reste aus der Gruppe, bestehend aus Halogen und Alkoxy substituiert ist, bedeuten, oder deren Salze. S9) Wirkstoffe aus der Klasse der 3-(5-Tetrazolylcarbonyl)-2-chinolone (S9), z.B. 1,2-Dihydro-4-hydroxy-1-ethyl-3-(5-tetrazolylcarbonyl)-2-chinolon (CAS-Reg.Nr.219479-18-2), 1,2-Dihydro-4-hydroxy-1-methyl-3-(5-tetrazolyl-carbonyl)-2-chinolon (CAS-Reg.Nr.95855-00-8), wie sie in der WO-A-1999/000020 beschrieben sind. S10) Verbindungen der Formeln (S10a) oder (S10b) wie sie in der WO-A-2007/023719 und WO-A-2007/023764 beschrieben sind
Figure imgf000430_0001
worin RG 1 Halogen, (C1-C4)-Alkyl, Methoxy, Nitro, Cyano, CF3, OCF3 YG, ZG unabhängig voneinander O oder S, nG eine ganze Zahl von 0 bis 4, RG 2 (C1-C16)-Alkyl, (C2-C6)-Alkenyl, (C3-C6)-Cycloalkyl, Aryl; Benzyl, Halogenbenzyl, RG 3 Wasserstoff oder (C1-C6)-Alkyl bedeutet. S11) Wirkstoffe vom Typ der Oxyimino-Verbindungen (S11), die als Saatbeizmittel bekannt sind, wie z. B. "Oxabetrinil" ((Z)-1,3-Dioxolan-2-ylmethoxyimino(phenyl)acetonitril) (S11-1), das als Saatbeiz-Safener für Hirse gegen Schäden von Metolachlor bekannt ist, "Fluxofenim" (1-(4- Chlorphenyl)-2,2,2-trifluor-1-ethanon-O-(1,3-dioxolan-2-ylmethyl)-oxim) (S11-2), das als Saatbeiz- Safener für Hirse gegen Schäden von Metolachlor bekannt ist, und "Cyometrinil" oder "CGA-43089" ((Z)-Cyanomethoxyimino(phenyl)acetonitril) (S11-3), das als Saatbeiz-Safener für Hirse gegen Schäden von Metolachlor bekannt ist. S12) Wirkstoffe aus der Klasse der Isothiochromanone (S12), wie z.B. Methyl-[(3-oxo-1H-2- benzothiopyran-4(3H)-yliden)methoxy]acetat (CAS-Reg.Nr.205121-04-6) (S12-1) und verwandte Verbindungen aus WO-A-1998/13361. S13) Eine oder mehrere Verbindungen aus Gruppe (S13): "Naphthalic anhydrid" (1,8-Naphthalindicarbonsäureanhydrid) (S13-1), das als Saatbeiz-Safener für Mais gegen Schäden von Thiocarbamatherbiziden bekannt ist, "Fenclorim" (4,6-Dichlor-2-phenylpyrimidin) (S13-2), das als Safener für Pretilachlor in gesätem Reis bekannt ist, "Flurazole" (Benzyl-2-chlor-4-trifluormethyl-1,3- thiazol-5-carboxylat) (S13-3), das als Saatbeiz-Safener für Hirse gegen Schäden von Alachlor und Metolachlor bekannt ist, "CL 304415" (CAS-Reg.Nr.31541-57-8) (4-Carboxy-3,4-dihydro-2H-1- benzopyran-4-essigsäure) (S13-4) der Firma American Cyanamid, das als Safener für Mais gegen Schäden von Imidazolinonen bekannt ist, "MG 191" (CAS-Reg.Nr.96420-72-3) (2-Dichlormethyl-2- methyl-1,3-dioxolan) (S13-5) der Firma Nitrokemia, das als Safener für Mais bekannt ist, "MG-838" (CAS-Reg.Nr.133993-74-5) (2-propenyl 1-oxa-4-azaspiro[4.5]decan-4-carbodithioat) (S13-6) der Firma Nitrokemia, "Disulfoton" (O,O-Diethyl S-2-ethylthioethyl phosphordithioat) (S13-7), "Dietholate" (O,O-Diethyl-O-phenylphosphorothioat) (S13-8), "Mephenate" (4-Chlorphenyl- methylcarbamat) (S13-9). S14) Wirkstoffe, die neben einer herbiziden Wirkung gegen Schadpflanzen auch Safenerwirkung an Kulturpflanzen wie Reis aufweisen, wie z. B. "Dimepiperate" oder "MY-93" (S-1-Methyl-1-phenylethyl-piperidin-1-carbothioat), das als Safener für Reis gegen Schäden des Herbizids Molinate bekannt ist, "Daimuron" oder "SK 23" (1-(1-Methyl-1- phenylethyl)-3-p-tolyl-harnstoff), das als Safener für Reis gegen Schäden des Herbizids Imazosulfuron bekannt ist, "Cumyluron" = "JC-940" (3-(2-Chlorphenylmethyl)-1-(1-methyl-1-phenyl-ethyl)harnstoff, siehe JP-A-60087254), das als Safener für Reis gegen Schäden einiger Herbizide bekannt ist, "Methoxyphenon" oder "NK 049" (3,3'-Dimethyl-4-methoxy-benzophenon), das als Safener für Reis gegen Schäden einiger Herbizide bekannt ist, "CSB" (1-Brom-4-(chlormethylsulfonyl)benzol) von Kumiai, (CAS-Reg.Nr.54091-06-4), das als Safener gegen Schäden einiger Herbizide in Reis bekannt ist. S15) Verbindungen der Formel (S15) oder deren Tautomere wie sie in der WO-A-2008/131861 und WO-A-2008/131860 beschrieben sind worin
Figure imgf000431_0001
RH 1 einen (C1-C6)-Haloalkylrest bedeutet und RH 2 Wasserstoff oder Halogen bedeutet und RH 3, RH 4 unabhängig voneinander Wasserstoff, (C1-C16)-Alkyl, (C2-C16)-Alkenyl oder (C2-C16)-Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy, (C1-C4)-Alkylthio, (C1-C4)-Alkylamino, Di[(C1-C4)-alkyl]-amino, [(C1-C4)-Alkoxy]-carbonyl, [(C1-C4)- Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, oder (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, oder (C4-C6)-Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6- gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, wobei jeder der letztgenannten 4 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)- Haloalkoxy, (C1-C4)-Alkylthio, (C1-C4)-Alkylamino, Di[(C1-C4)-alkyl]-amino, [(C1-C4)Alkoxy]- carbonyl, [(C1-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet oder RH3 (C1-C4)-Alkoxy, (C2-C4)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C4)-Haloalkoxy bedeutet und RH4 Wasserstoff oder (C1-C4)-Alkyl bedeutet oder RH3 und RH4 zusammen mit dem direkt gebundenen N-Atom einen vier- bis achtgliedrigen heterocyclischen Ring, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (C1-C4)-Alkyl, (C1-C4)-Haloalkyl, (C1-C4)-Alkoxy, (C1-C4)-Haloalkoxy und (C1-C4)-Alkylthio substituiert ist, bedeutet. S16) Wirkstoffe, die vorrangig als Herbizide eingesetzt werden, jedoch auch Safenerwirkung auf Kulturpflanzen aufweisen, z.B. (2,4-Dichlorphenoxy)essigsäure (2,4-D), (4-Chlorphenoxy)essigsäure, (R,S)-2-(4-Chlor-o-tolyloxy)propionsäure (Mecoprop), 4-(2,4-Dichlorphenoxy)buttersäure (2,4-DB), (4- Chlor-o-tolyloxy)-essigsäure (MCPA), 4-(4-Chlor-o-tolyloxy)buttersäure, 4-(4-Chlorphenoxy)- buttersäure, 3,6-Dichlor-2-methoxybenzoesäure (Dicamba), 1-(Ethoxycarbonyl)ethyl-3,6-dichlor-2- methoxybenzoat (Lactidichlor-ethyl). Pflanzenreife beeinflussende Stoffe: Als Kombinationspartner für die Verbindungen der allgemeinen Formel (I) in Mischungsformulierungen oder im Tank-Mix sind beispielsweise bekannte Wirkstoffe, die auf einer Inhibition von beispielsweise 1-Aminocyclopropan-1-carboxylatsynthase, 1-aminocyclopropane-1-carboxylatoxidase und den Ethylenrezeptoren, z. B. ETR1, ETR2, ERS1, ERS2 oder EIN4, beruhen, einsetzbar, wie sie z. B. in Biotechn. Adv.2006, 24, 357-367; Bot. Bull. Acad. Sin.199, 40, 1-7 oder Plant Growth Reg.1993, 13, 41-46 und dort zitierter Literatur beschrieben sind. Als bekannte die Pflanzenreife beeinflussende Stoffe, die mit den Verbindungen der allgemeinen Formel (I) kombiniert werden können, sind z.B. folgende Wirkstoffe zu nennen (die Verbindungen sind entweder mit dem "common name" nach der International Organization for Standardization (ISO) oder mit dem chemischen Namen oder mit der Codenummer bezeichnet) und umfassen stets sämtliche Anwendungsformen wie Säuren, Salze, Ester und Isomere wie Stereoisomere und optische Isomere. Dabei sind beispielhaft eine und zum Teil auch mehrere Anwendungsformen genannt: Rhizobitoxin, 2-Amino-ethoxy-vinylglycin (AVG), Methoxyvinylglycin (MVG), Vinylglycin, Aminooxyessigsäure, Sinefungin, S-Adenosylhomocystein, 2-Keto-4-Methylthiobutyrat, (Isopropyliden)-aminooxyessigsäure-2-(methoxy)-2-oxoethylester, (Isopropyliden)- aminooxyessigsäure-2-(hexyloxy)-2-oxoethylester, (Cyclohexyliden)-aminooxyessigsäure-2- (isopropyloxy)-2-oxoethylester, Putrescin, Spermidin, Spermin, 1,8-Diamino-4-aminoethyloctan, L- Canalin, Daminozid, 1-Aminocyclopropyl-1-carbonsäure-methylester, N-Methyl-1-aminocyclopropyl-1- carbonsäure, 1-Aminocyclopropyl-1-carbonsäureamid, Substituierte 1-Aminocyclopropyl-1- carbonsäurederivate wie sie in DE3335514, EP30287, DE2906507 oder US5123951 beschrieben werden, 1-Aminocyclopropyl-1-hydroxamsäure, 1-Methylcyclopropen, 3-Methylcyclopropen, 1- Ethylcyclopropen, 1-n-Propylcyclopropen, 1-Cyclopropenyl-Methanol, Carvon, Eugenol, Natriumcycloprop-1-en-1-ylacetat, Natriumcycloprop-2-en-1-ylacetat, Natrium-3-(cycloprop-2-en-1- yl)propanoat, Natrium-3-(cycloprop-1-en-1-yl)propanoat, Jasmonsäure, Jasmonsäuremethylester, Jasmonsäureethylester, Prohydrojasmon, 2-Fluor-N-(3-methoxyphenyl)-9H-purin-6-amin. Pflanzengesundheit und Keimung beeinflussende Stoffe: Als Kombinationspartner für die Verbindungen der allgemeinen Formel (I) in Mischungsformulierungen oder im Tank-Mix sind beispielsweise bekannte Wirkstoffe, die die Pflanzengesundheit oder die Keimung beeinflussen, einsetzbar (die Verbindungen sind entweder mit dem "common name" nach der International Organization for Standardization (ISO) oder mit dem chemischen Namen oder mit der Codenummer bezeichnet und umfassen stets sämtliche Anwendungsformen wie Säuren, Salze, Ester und Isomere wie Stereoisomere und optische Isomere): Sarcosin, Phenylalanin, Tryptophan, N'-Methyl-1- phenyl-1-N,N-diethylaminomethanesulfonamid, Apio-galacturonane wie sie in WO2010017956 beschrieben werden, 4-Oxo-4-[(2-phenylethyl)amino]butansäure, 4-{[2-(1H-Indol-3-yl)ethyl]amino}-4- oxobutansäure, 4-[(3-Methylpyridin-2-yl)amino]-4-oxobutansäure, Allantoin, 5-Aminolevulinsäure, (2S,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-chromen-3,5,7-triol und strukturell verwandte Catechine wie sie in WO2010122956 beschrieben werden, 2-Hydroxy-4-(methylsulfanyl)butansäure, (3Ε,3αR,8βS)-3-({[(2R)-4-Methyl-5-oxo-2,5-dihydrofuran-2-yl]oxy}methylen)-3,3α,4,8β-tetrahydro- 2H-indeno[1,2-b]furan-2-on und analoge Lactone wie sie in EP2248421 beschrieben werden, Abscisinsäure, (2Z,4E)-5-[6-Ethinyl-1-hydroxy-2,6-dimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta- 2,4-diensäure, Methyl-(2Z,4E)-5-[6-ethinyl-1-hydroxy-2,6-dimethyl-4-oxocyclohex-2-en-1-yl]-3- methylpenta-2,4-dienoat, 4-Phenylbuttersäure, Natrium-4-phenylbutanoat, Kalium-4-phenylbutanoat. Herbizide oder Pflanzenwachstumsregulatoren: Als Kombinationspartner für die Verbindungen der allgemeinen Formel (I) in Mischungsformulierungen oder im Tank-Mix sind beispielsweise bekannte Wirkstoffe, die auf einer Inhibition von beispielsweise Acetolactat-Synthase, Acetyl-CoA-Carboxylase, Cellulose-Synthase, Enolpyruvylshikimat-3-phosphat- Synthase, Glutamin-Synthetase, p-Hydroxyphenylpyruvat-Dioxygenase, Phytoendesaturase, Photosystem I, Photosystem II, Protoporphyrinogen-Oxidase beruhen oder als Pflanzenwuchsregulatoren wirken, einsetzbar, wie sie z.B. aus Weed Research 26 (1986) 441-445 oder "The Pesticide Manual", 14th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2006 und dort zitierter Literatur beschrieben sind. Als bekannte Herbizide oder Pflanzenwachstumsregulatoren, die mit Verbindungen der allgemeinen Formel (I) kombiniert werden können, sind z.B. folgende Wirkstoffe zu nennen (die Verbindungen sind entweder mit dem "common name" nach der International Organization for Standardization (ISO) oder mit dem chemischen Namen oder mit der Codenummer bezeichnet) und umfassen stets sämtliche Anwendungsformen wie Säuren, Salze, Ester und Isomere wie Stereoisomere und optische Isomere. Dabei sind beispielhaft eine und zum Teil auch mehrere Anwendungsformen genannt: Acetochlor, Acifluorfen, Acifluorfen-methyl, Acifluorfen-Natrium, Aclonifen, Alachlor, Allidochlor, Alloxydim, Alloxydim-Natrium, Ametryn, Amicarbazon, Amidochlor, Amidosulfuron, 4-Amino-3- chlor-6-(4-chlor-2-fluor-3-methylphenyl)-5-fluorpyridine-2-carbonsäure, Aminocyclopyrachlor, Aminocyclopyrachlor-potassium, Aminocyclopyrachlor-methyl, Aminopyralid, Aminopyralid- dimethylammonium, Aminopyralid-tripromine, Amitrole, Ammoniumsulfamate, Anilofos, Asulam, Asulam-Kalium, Asulam-Natrium, Atrazin, Azafenidin, Azimsulfuron, Beflubutamid, (S)-(-)- Beflubutamid, Beflubutamid-M, Benazolin, Benazolin-ethyl, Benazolin-dimethylammonium, Benazolin-Klaium, Benfluralin, Benfuresate, Bensulfuron, Bensulfuron-methyl, Bensulid, Bentazon, Bentazon-Natrium, Benzobicyclon, Benzofenap, Bicyclopyrone, Bifenox, Bilanafos, Bilanafos-Natium, Bipyrazone, Bispyribac, Bispyribac-Natium, Bixlozon, Bromacil, Bromacil-lithium, Bromacil-Natrium, Bromobutid, Bromofenoxim, Bromoxynil, Bromoxynilbutyrat, Bromoxynil-Kalium, Bromoxynil- heptanoat und Bromoxynil-octanoat, Busoxinon, Butachlor, Butafenacil, Butamifos, Butenachlor, Butralin, Butroxydim, Butylat, Cafenstrol, Cambendichlor, Carbetamide, Carfentrazon, Carfentrazon- Ethyl, Chloramben, Chloramben-ammonium, Chloramben-diolamin, Chlroamben-methyl, Chloramben- methylammonium, Chloramben-Natium, Chlorbromuron, Chlorfenac, Chlorfenac-ammonium, Chlorfenac-Natium, Chlorfenprop, Chlorfenprop-methyl, Chlorflurenol, Chlorflurenol-methyl, Chloridazon, Chlorimuron, Chlorimuron-ethyl, Chlorphthalim, Chlortoluron, Chlorosulfuron, Chlorthal, Chlorthal-dimethyl, Chlorthal-monomethyl, Cinidon, Cinidon-ethyl, Cinmethylin, exo-(+)-Cinmethylin, i.e. (1R,2S,4S)-4-isopropyl-1-methyl-2-[(2-methylbenzyl)oxy]-7-oxabicyclo[2.2.1]heptan, exo-(-)- Cinmethylin, i.e. (1R,2S,4S)-4-isopropyl-1-methyl-2-[(2-methylbenzyl)oxy]-7-oxabicyclo[2.2.1]heptan, Cinosulfuron, Clacyfos, Clethodim, Clodinafop, Clodinafop-ethyl, Clodinafop-propargyl, Clomazon, Clomeprop, Clopyralid, Clopyralid-methyl, Clopyralid-olamin, Clopyralid-Kalium, Clopyralid- tripomin, Cloransulam, Cloransulam-methyl, Cumyluron, Cyanamide, Cyanazine, Cycloat, Cyclopyranil, Cyclopyrimorat, Cyclosulfamuron, Cycloxydim, Cyhalofop, Cyhalofop-butyl, Cyprazin, 2,4-D (sowie die Ammonium, Butotyl, Butyl, Cholin, Diethylammonium, Dimethylammonium, Diolamin, Doboxyl, Dodecylammonium, Etexyl, Ethyl, 2-Ethylhexyl, Heptylammonium, Isobutyl, Isooctyl, Isopropyl, Isopropylammonium, Lithium, Meptyl, Methyl, Kalium, Tetradecylammonium, Triethylammonium, Triisopropanolammonium, Tripromin and Trolamin Salze davon), 2,4-DB, 2,4-DB- butyl, 2,4-DB-Dimethylammonium, 2,4-DB-isooctyl, 2,4-DB-Kalium und 2,4-DB-Natrium, Daimuron (Dymron), Dalapon, Dalapon-Calcium, Dalapon-Magnesium, Dalapon-Natium, Dazomet, Dazomet- Natrium, n-Decanol, 7-Deoxy-D-sedoheptulose, Desmedipham, Detosyl-pyrazolat (DTP), Dicamba und seine Salze (z.B. Dicamba-biproamine, Dicamba-N,N-Bis(3-aminopropyl)methylamine, Dicamba- butotyl, Dicamba-choline, Dicamba-Diglycolamine, Dicamba-Dimethylammonium, Dicamba- Diethanolaminemmonium, Dicamba-Diethylammonium, Dicamba-isopropylammonium, Dicamba- methyl, Dicamba-monoethanolamin, Dicamba-olamin, Dicamba-Kalium, Dicamba-Natium, Dicamba- Triethanolamin), Dichlobenil, 2-(2,4-Dichlorbenzyl)-4,4-dimethyl-1,2-oxazolidin-3-on, 2-(2,5- Dichlorbenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, Dichlorprop, Dichlorprop-butotyl, Dichlorprop- Dimethylammonium, Dichhlorprop-etexyl, Dichlorprop-ethylammonium, Dichlorprop-isoctyl, Dichlorprop-methyl, Dichlorprop-Kalium, Dichlorprop-Natrium, Dichlorprop-P, Dichlorprop-P- Dimethylammonium, Dichlorprop-P-etexyl, Dichlorprop-P-potassium, Dichlorprop-Natrium, Diclofop, Diclofop-methyl, Diclofop-P, Diclofop-P-methyl, Diclosulam, Difenzoquat, Difenzoquat-metilsulfate, Diflufenican, Diflufenzopyr, Diflufenzopyr-Natrium, Dimefuron, Dimepiperate, Dimesulfazet, Dimethachlor, Dimethametryn, Dimethenamid, Dimethenamid-P, Dimetrasulfuron, Dinitramine, Dinoterb, Dinoterb-Acetate, Diphenamid, Diquat, Diquat-Dibromid, Diquat-Dichloride, Dithiopyr, Diuron, DNOC, DNOC-Ammonium, DNOC-Kalium, DNOC-Natrium, Endothal, Endothal- Diammonium, Endothal-Dikalium, Endothal-Dinatrium, Epyrifenacil (S-3100), EPTC, Esprocarb, Ethalfluralin, Ethametsulfuron, Ethametsulfuron-Methyl, Ethiozin, Ethofumesate, Ethoxyfen, Ethoxyfen-Ethyl, Ethoxysulfuron, Etobenzanid, F-5231, i.e. N-[2-Chlor-4-fluor-5-[4-(3-fluorpropyl)- 4,5-dihydro-5-oxo-1H-tetrazol-1-yl]-phenyl]-ethansulfonamid, F-7967, i.e.3-[7-Chlor-5-fluor-2- (trifluormethyl)-1H-benzimidazol-4-yl]-1-methyl-6-(trifluormethyl)pyrimidin-2,4(1H,3H)-dion, Fenoxaprop, Fenoxaprop-P, Fenoxaprop-Ethyl, Fenoxaprop-P-Ethyl, Fenoxasulfone, Fenpyrazone, Fenquinotrione, Fentrazamid, Flamprop, Flamprop-Isoproyl, Flamprop-Methyl, Flamprop-M-Isopropyl, Flamprop-M-Methyl, Flazasulfuron, Florasulam, Florpyrauxifen, Florpyrauxifen-benzyl, Fluazifop, Fluazifop-Butyl, Fluazifop-Methyl, Fluazifop-P, Fluazifop-P-Butyl, Flucarbazone, Flucarbazone- sodium, Flucetosulfuron, Fluchloralin, Flufenacet, Flufenpyr, Flufenpyr-Ethyl, Flumetsulam, Flumiclorac, Flumiclorac-Pentyl, Flumioxazin, Fluometuron, Flurenol, Flurenol-Butyl, - Dimethylammonium und -Methyl, Fluorglycofen, Fluorglycofen-Ethyl, Flupropanat, Flupropanat- Natrium, Flupyrsulfuron, Flupyrsulfuron-Methyl, Flupyrsulfuron-Methyl-Natrium, Fluridon, Flurochloridon, Fluroxypyr, Fluroxypyr-Butometyl, Fluroxypyr-Meptyl, Flurtamon, Fluthiacet, Fluthiacet-Methyl, Fomesafen, Fomesafen-Natrium, Foramsulfuron, Foramsulfuron-Natrium, Fosamine, Fosamine-Ammonium, Glufosinat, Glufosinat-Ammonium, Glufosinat-Natrium, L-Glufosinat- Ammonium, L-Glufosinat-Natrium, Glufosinat-P-Natrium, Glufosinat-P-Ammonium, Glyphosat, Glyphosat-Ammonium, Glyphosat-Isopropylammonium, Glyphosat-Diammonium, Glyphosat- Dimethylammonium, Glyphosat-Kalium, Glyphosat-Natrium, Glyphosat-Sesquinatrium und Glyphosat- Trimesium, H-9201, i.e. O-(2,4-Dimethyl-6-nitrophenyl)-O-ethyl-isopropylphosphoramidothioat, Halauxifen, Halauxifen-methyl, Halosafen, Halosulfuron, Halosulfuron-Methyl, Haloxyfop, Haloxyfop- P, Haloxyfop-Ethoxyethyl, Haloxyfop-P-Ethoxyethyl, Haloxyfop-Methyl, Haloxyfop-P-Methyl, Haloxifop-Natrium, Hexazinon, HNPC-A8169, i.e. Prop-2-yn-1-yl (2S)-2-{3-[(5-tert-butylpyridin-2- yl)oxy]phenoxy}propanoat, HW-02, i.e.1-(Dimethoxyphosphoryl)-ethyl-(2,4-dichlorphenoxy)acetat, Hydantocidin, Imazamethabenz, Imazamethabenz-Methyl, Imazamox, Imazamox-Ammonium, Imazapic, Imazapic-Ammonium, Imazapyr, Imazapyr-Isopropylammonium, Imazaquin, Imazaquin- Ammonium, Imazaquin-Methyl, Imazethapyr, Imazethapyr-Ammonium, Imazosulfuron, Indanofan, Indaziflam, Iodosulfuron, Iodosulfuron-Methyl, Iodosulfuron-Methyl-Natrium, Ioxynil, Ioxynil- Lithium, -Octanoat, -Kalium und Natrium, Ipfencarbazon, Isoproturon, Isouron, Isoxaben, Isoxaflutole, Karbutilat, KUH-043, i.e.3-({[5-(Difluormethyl)-1-methyl-3-(trifluormethyl)-1H-pyrazol-4- yl]methyl}sulfonyl)-5,5-dimethyl-4,5-dihydro-1,2-oxazol, Ketospiradox, Ketospiradox-Kalium, Lactofen, Lenacil, Linuron, MCPA, MCPA-Butotyl, -Butyl, -Dimethylammonium, -Diolamin, -2- Ethylhexyl, -Ethyl, -Isobutyl, Isoctyl, -Isopropyl, -Isopropylammonium, -Methyl, Olamin, -Kalium, – Natrium und -Trolamin, MCPB, MCPB-Methyl, -Ethyl und -Natrium, Mecoprop, Mecoprop-Butotyl, Mecoprop- dimethylammonium, Mecoprop-Diolamin, Mecoprop-Etexyl, Mecoprop-Ethadyl, Mecoprop-Isoctyl, Mecoprop-Methyl, Mecoprop-Kalium, Mecoprop-Natrium, und Mecoprop- Trolamin, Mecoprop-P, Mecoprop-P-Butotyl, -Dimethylammonium, -2-Ethylhexyl und -Kalium, Mefenacet, Mefluidid, Mefluidid-Diolamin, Mefluidid-Kalium, Mesosulfuron, Mesosulfuron-Methyl, Mesosulfuron-Natrium, Mesotrion, Methabenzthiazuron, Metam, Metamifop, Metamitron, Metazachlor, Metazosulfuron, Methabenzthiazuron, Methiopyrsulfuron, Methiozolin, Methyl isothiocyanat, Metobromuron, Metolachlor, S-Metolachlor, Metosulam, Metoxuron, Metribuzin, Metsulfuron, Metsulfuron-Methyl, Molinat, Monolinuron, Monosulfuron, Monosulfuron-Methyl, MT- 5950, i.e. N-[3-Chlor-4-(1-methylethyl)-phenyl]-2-methylpentanamid, NGGC-011, Napropamid, NC- 310, i.e.4-(2,4-Dichlorbenzoyl)-1-methyl-5-benzyloxypyrazol, NC-656, i.e. 3- [(Isopropylsulfonyl)methyl]-N-(5-methyl-1,3,4-oxadiazol-2-yl)-5-(trifluormethyl)[1,2,4]triazolo-[4,3- a]pyridin-8-carboxamid, Neburon, Nicosulfuron, Nonansäure (Pelargonsäure), Norflurazon, Ölsäure (Fettsäuren), Orbencarb, Orthosulfamuron, Oryzalin, Oxadiargyl, Oxadiazon, Oxasulfuron, Oxaziclomefone, Oxyfluorfen, Paraquat, Paraquat-dichlorid, Paraquat-Dimethylsulfat, Pebulat, Pendimethalin, Penoxsulam, Pentachlorphenol, Pentoxazon, Pethoxamid, Petroleumöl, Phenmedipham, Phenmedipham-Ethyl, Picloram, Picloram-dimethylammonium, Picloram-Etexyl, Picloram-Isoctyl, Picloram-Methyl, Picloram-Olamin, Picloram-Kalium, Picloram-Triethylammonium, Picloram- Tripromin, Picloram-Trolamin, Picolinafen, Pinoxaden, Piperophos, Pretilachlor, Primisulfuron, Primisulfuron-Methyl, Prodiamine, Profoxydim, Prometon, Prometryn, Propachlor, Propanil, Propaquizafop, Propazine, Propham, Propisochlor, Propoxycarbazone, Propoxycarbazone-Natrium, Propyrisulfuron, Propyzamid, Prosulfocarb, Prosulfuron, Pyraclonil, Pyraflufen, Pyraflufen-Ethyl, Pyrasulfotol, Pyrazolynat (Pyrazolat), Pyrazosulfuron, Pyrazosulfuron-Ethyl, Pyrazoxyfen, Pyribambenz, Pyribambenz-Isopropyl, Pyribambenz-Propyl, Pyribenzoxim, Pyributicarb, Pyridafol, Pyridat, Pyriftalid, Pyriminobac, Pyriminobac-Methyl, Pyrimisulfan, Pyrithiobac, Pyrithiobac-Natrium, Pyroxasulfon, Pyroxsulam, Quinclorac, Quinclorac-Dimethylammonium, Quinclorac-Methyl, Quinmerac, Quinoclamin, Quizalofop, Quizalofop-Ethyl, Quizalofop-P, Quizalofop-P-Ethyl, Quizalofop-P-Tefuryl, QYM201, i.e.1-{2-Chlor-3-[(3-cyclopropyl-5-hydroxy-1-methyl-1H-pyrazol-4- yl)carbonyl]-6-(trifluormethyl)phe-nyl}piperidin-2-on, Rimsulfuron, Saflufenacil, Sethoxydim, Siduron, Simazine, Simetryn, SL-261, Sulcotrione, Sulfentrazone, Sulfometuron, Sulfometuron-Methyl, Sulfosulfuron, , SYP-249, i.e.1-Ethoxy-3-methyl-1-oxobut-3-en-2-yl-5-[2-chlor-4- (trifluormethyl)phenoxy]-2-nitrobenzoat, SYP-300, i.e.1-[7-Fluor-3-oxo-4-(prop-2-in-1-yl)-3,4- dihydro-2H-1,4-benzoxazin-6-yl]-3-propyl-2-thioxoimidazolidin-4,5-dion, 2,3,6-TBA, TCA (Trichloressigsäure) und seine Salze, z.B. TCA-ammonium, TCA-Calcium, TCA-Ethyl, TCA- Magnesium, TCA-Natrium, Tebuthiuron, Tefuryltrione, Tembotrion, Tepraloxydim, Terbacil, Terbucarb, Terbumeton, Terbuthylazine, Terbutryn, Tetflupyrolimet, Thaxtomin, Thenylchlor, Thiazopyr, Thiencarbazone, Thiencarbazon-Methyl, Thifensulfuron, Thifensulfuron-Methyl, Thiobencarb, Tiafenacil, Tolpyralat, Topramezon, Tralkoxydim, Triafamon, Tri-allat, Triasulfuron, Triaziflam, Tribenuron, Tribenuron-Methyl, Triclopyr, Triclopyr-Butotyl, Triclopyr-Cholin, Triclopyr- Ethyl, Triclopyr-Triethylammonium, Trietazine, Trifloxysulfuron, Trifloxysulfuron-Natrium, Trifludimoxazin, Trifluralin, Triflusulfuron, Triflusulfuron-Methyl, Tritosulfuron, Harnstoffsulfat, Vernolat, XDE-848, ZJ-0862, i.e.3,4-Dichlor-N-{2-[(4,6-dimethoxypyrimidin-2-yl)oxy]benzyl}anilin, 3-(2-Chlor-4-fluor-5-(3-methyl-2,6-dioxo-4-trifluormethyl-3,6-dihydropyrimidin-1(2H)-yl)phenyl)-5- methyl-4,5-dihydroisoxazole-5-carbonsäureethylester, Ethyl-[(3-{2-chlor-4-fluor-5-[3-methyl-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}pyridin-2-yl)oxy]acetat, 3-Chlor-2- [3-(difluormethyl)isoxazolyl-5-yl]phenyl-5-chlorpyrimidin-2-ylether, 2-(3,4-Dimethoxyphenyl)-4-[(2- hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-6-methylpyridazine-3(2H)-on, 2-({2-[(2- Methoxyethoxy)methyl]-6-methylpyridin-3-yl}carbonyl)cyclohexane-1,3-dion, (5-Hydroxy-1-methyl- 1H-pyrazol-4-yl)(3,3,4-trimethyl-1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl)methanon, 1-Methyl-4- [(3,3,4-trimethyl-1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl)carbonyl]-1H-pyrazol-5-yl propan-1- sulfonat, 4-{2-Chlor-3-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4-(methylsulfonyl)benzoyl}-1-methyl- 1H-pyrazol-5-yl-1,3-dimethyl-1H-pyrazole-4-carboxylat; Cyanomethyl-4-amino-3-chlor-5-fluor-6-(7- fluor-1H-indol-6-yl)pyridine-2-carboxylat, Prop-2-yn-1-yl 4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol- 6-yl)pyridine-2-carboxylat, Methyl-4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridine-2- carboxylat, 4-Amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridine-2-carbonsäure, Benzyl-4-amino- 3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridine-2-carboxylat, Ethyl-4-amino-3-chlor-5-fluor-6-(7- fluor-1H-indol-6-yl)pyridine-2-carboxylat, Methyl-4-amino-3-chlor-5-fluor-6-(7-fluor-1-isobutyryl-1H- indol-6-yl)pyridine-2-carboxylat, Methyl 6-(1-acetyl-7-fluor-1H-indol-6-yl)-4-amino-3-chlor-5- fluorpyridine-2-carboxylat, Methyl-4-amino-3-chlor-6-[1-(2,2-dimethylpropanoyl)-7-fluor-1H-indol-6- yl]-5-fluorpyridine-2-carboxylat, Methyl-4-amino-3-chlor-5-fluor-6-[7-fluor-1-(methoxyacetyl)-1H- indol-6-yl]pyridine-2-carboxylat, Kalium 4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridine-2- carboxylat, Natrium-4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridine-2-carboxylat, Butyl-4- amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridine-2-carboxylat, 4-Hydroxy-1-methyl-3-[4- (trifluormethyl)pyridin-2-yl]imidazolidin-2-one, 3-(5-tert-butyl-1,2-oxazol-3-yl)-4-hydroxy-1- methylimidazolidin-2-on, 3-[5-Chlor-4-(trifluormethyl)pyridin-2-yl]-4-hydroxy-1-methylimidazolidin- 2-on, 4-Hydroxy-1-methoxy-5-methyl-3-[4-(trifluormethyl)pyridin-2-yl]imidazolidin-2-on, 6-[(2- Hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-1,5-dimethyl-3-(2-methylphenyl)chinazolin-2,4(1H,3H)- dion, 3-(2,6-Dimethylphenyl)-6-[(2-hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-1-methylchinazolin- 2,4(1H,3H)-dion, 2-[2-chlor-4-(methylsulfonyl)-3-(morpholin-4-ylmethyl)benzoyl]-3-hydroxycyclohex- 2-en-1-on, 1-(2-carboxyethyl)-4-(pyrimidin-2-yl)pyridazin-1-iumsalz (mit passenden Anionen wie z.B Chlorid, Acetat oder Trifluoracetat), 1-(2-carboxyethyl)-4-(pyridazin-3-yl)pyridazin-1-iumsalz (mit passenden Anionen wie z.B. Chlorid, Acetat oder Trifluoracetat), 4-(Pyrimidin-2-yl)-1-(2- sulfoethyl)pyridazin-1-ium salz iumsalz (mit passenden Anionen wie z.B Chlorid, Acetat oder Trifluoracetat), 4-(Pyridazin-3-yl)-1-(2-sulfoethyl)pyridazin-1-ium salz iumsalz (mit passenden Anionen wie z.B Chlorid, Acetat oder Trifluoracetat). Die Erfindung soll durch die nachfolgenden biologischen Beispiele veranschaulicht werden, ohne sie jedoch darauf einzuschränken. In vivo-Analysen – Teil A Samen von mono- bzw. dikotylen Kulturpflanzen wurden in Holzfaser- oder Plastiktöpfen in sandigem Lehmboden ausgesät, mit Erde oder Sand abgedeckt und im Gewächshaus unter guten Wachstumsbedingungen angezogen. Die Behandlung der Versuchspflanzen erfolgte im frühen Laubblattstadium (BBCH10 – BBCH13). Zur Gewährleistung einer uniformen Wasserversorgung vor Stressbeginn wurden die bepflanzten Töpfe vor Substanzapplikation durch Anstaubewässerung mit Wasser versorgt. Die in Form von benetzbaren Pulvern (WP) formulierten erfindungsgemäßen Verbindungen wurden als wässrige Suspension mit einer Wasseraufwandmenge von umgerechnet 600 l/ha unter Zusatz von 0,2% Netzmittel (z.B. Agrotin) auf die grünen Pflanzenteile gesprüht. Unmittelbar nach Substanzapplikation erfolgte die Stressbehandlung der Pflanzen. Die Holzfasertöpfe wurden dazu in Plastikeinsätze transferiert, um anschließendes, zu schnelles Abtrocknen zu verhindern. Der Trockenstress wurde durch langsames Abtrocknen unter folgenden Bedingungen induziert: „Tag“: 14 Stunden beleuchtet bei ~ 26-30°C „Nacht“: 10 Stunden ohne Beleuchtung bei ~ 18-20°C. Die Dauer der jeweiligen Stressphasen richtete sich hauptsächlich nach dem Zustand der gestressten Kontrollpflanzen. Sie wurde (durch Wiederbewässerung und Transfer in ein Gewächshaus mit guten Wachstumsbedingungen) beendet, sobald irreversible Schäden an den gestressten Kontrollpflanzen zu beobachten waren. Nach Beendigung der Stressphase folgte eine ca.4-7 tägige Erholungsphase, während der die Pflanzen abermals unter guten Wachstumsbedingungen im Gewächshaus gehalten wurden. Die Dauer der Erholungsphase richtete sich hauptsächlich danach, wann die Versuchspflanzen einen Zustand erreicht hatten, der eine visuelle Bonitur potenzieller Effekte ermöglichte, und ist daher variabel. Wenn dieser Zeitpunkt erreicht war, wurden die Schadintensitäten visuell im Vergleich zu unbehandelten, ungestressten Kontrollen gleichen Alters bonitiert. Die Erfassung der Schadintensität erfolgte zunächst in Prozent. Aus diesen Werten wurde sodann der Wirkungsgrad der Testverbindungen nachfolgender Formel ermittelt:
Figure imgf000439_0001
WG: Wirkungsgrad (Efficacy) SIs: Schadintensität der gestressten Kontrollpflanzen SIt: Schadintensität der mit Testverbindung behandelten, gestressten Pflanzen Bei den in untenstehenden Tabellen A-1 bis A-3 angegebenen Werten handelt es sich um Mittelwerte aus mindestens einem Versuch mit mindestens zwei Replikaten, wobei die Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) unter Trockenstress auf verschiedene Kulturpflanzen dargestellt sind. Tabelle A-1
Figure imgf000440_0001
Figure imgf000153_0001
Spectroscopic data of selected examples in the table: The spectroscopic data of selected examples in the table listed below were obtained either via classical NMR interpretation and/or via1H NMR peak list method evaluated. a) Classic interpretation: Example No. I.4-3:1H NMR (400 MHz, d6-DMSO) δ ppm 8.17 (d, 1H), 8.09 (br. s, 1H, NH), 7.64 (d, 1H), 7.58 (d, 1H), 7.46-7.34 (m , 4H), 7.26 (m, 1H), 6.98 (m, 1H), 4.49-4.44 (m, 1H), 4.05-4.00 (m, 1H), 3.59-3.53 (dd, 1H), 2.94-2.87 (dd , 1H), 2.37-2.31 (dd, 1H). Example No. I.4-4:1H NMR (400 MHz, d6-DMSO) δ ppm 8.50 (br. s, 1H, NH), 7.55 (d, 2H), 7.43 (d, 2H), 7.28 (d, 2H), 7.19 (d, 2H ), 6.81 (br. d, 1H, NH), 4.42-4.36 (m, 1H), 4.14-4.08 (m, 1H), 3.69-3.63 (dd, 1H), 2.94-2.87 (dd, 1H), 2.47 -2.40 (dd, 1H), 2.28 (s, 3H). Example No. I.4-15:1H NMR (400 MHz, i.e6-DMSO) δ ppm 8.81 (s, 1H), 8.42 (br. m, 1H, NH), 7.95 (m, 1H), 7.57 (d, 2H), 7.39 (d, 1H), 7.00 (br. d, 1H, NH), 6.96 (d, 2H), 4.42-4.38 (m, 1H), 4.14-4.08 (m, 1H), 3.75 (s, 3H), 3.67-3.63 (dd, 1H), 2.93-2.86 ( dd, 1H), 2.47-2.41 (dd, 1H). Example No. I.4-16:1H NMR (400 MHz, i.e6-DMSO) δ ppm 8.89 (s, 1H), 8.42 (br. m, 1H, NH), 7.96 (m, 1H), 7.58 (m, 1H), 7.46-7.39 (m, 4H), 7.00 (br. d, 1H, NH), 4.51-4.45 (m, 1H), 4.02-3.97 (m, 1H), 3.59-3.54 (dd, 1H), 2.89-2.81 (dd, 1H), 2.46-2.39 (dd, 1H ). Example No. I.4-17:1H NMR (400 MHz, d6-DMSO) δ ppm 8.62 (br. s, 1H, NH), 7.89 (s, 1H), 7.54 (d, 1H), 7.45-7.35 (m, 3H), 7.29 (d , 2H), 6.80 (br. d, 1H, NH), 4.51-4.45 (m, 1H), 4.02-3.97 (m, 1H), 3.59-3.54 (dd, 1H), 2.85-2.81 (dd, 1H) , 2.44-2.37 (dd, 1H). Example No. I.4-18:1H NMR (400 MHz, d6-DMSO) δ ppm 8.69 (br. s, 1H, NH), 7.59 (d, 1H), 7.49-7.34 (m, 5H), 7.28 (d, 2H), 7.22 (d , 1H), 6.82 (br. d, 1H, NH), 4.43-4.38 (m, 1H), 4.18-4.14 (m, 1H), 3.72-3.68 (dd, 1H), 2.96-2.91 (dd, 1H) , 2.46 (dd, 1H). Example No. I.4-19:1H NMR (400 MHz, d6-DMSO) δ ppm 8.18 (m, 1H), 8.00 (br. s, 1H, NH), 7.91 (s, 1H), 7.65 (d, 1H), 7.57 (d, 1H ), 7.48-7.39 (m, 2H), 7.30-7.22 (m, 2H), 6.99-6.96 (m, 1H), 4.43-4.38 (m, 1H), 4.19-4.14 (m, 1H), 3.73-3.69 (dd, 1H), 3.03-2.96 (dd, 1H), 2.46-2.40 (dd, 1H). Example No. I.4-20:1H NMR (400 MHz, d6-DMSO) δ ppm 8.18 (d, 1H), 8.00 (br. s, 1H, NH), 7.72 (d, 2H), 7.67 (d, 1H), 7.48-7.42 (m , 3H), 7.22 (m, 1H), 6.99-6.96 (m, 1H), 4.43-4.37 (m, 1H), 4.18-4.13 (m, 1H), 3.70-3.66 (dd, 1H), 3.03-2.95 (dd, 1H), 2.47-2.39 (dd, 1H). Example No. I.4-27:1H NMR (400 MHz, i.e6-DMSO) δ ppm 9.26 (br. s, 1H, NH), 8.92 (br. m, 1H), 7.73 (d, 2H), 7.57 (m, 1H), 7.46 (d, 2H), 7.12 (d, 1H), 6.81 (d, 1H), 4.51-4.41 (m, 1H), 4.19-4.14 (m, 1H), 3.75-3.70 (dd, 1H), 3.02-2.94 (dd, 1H), 2.47 (m, 1H), 2.33 (s, 3H). Example No. I.4-31:1H NMR (400 MHz, i.e6-DMSO) δ ppm 8.82 (s, 1H), 8.42 (d, 1H), 7.95-7.91 (m, 1H), 7.71 (d, 2H), 7.45 (d, 2H), 7.38 (d, 1H), 7.03 (m, 1H), 4.45-4.38 (m, 1H), 4.16-4.11 (m, 1H), 3.71-3.66 (dd, 1H), 2.97-2.90 (dd, 1H), 2.49-2.45 (dd, 1H) . Example No. I.4-32:1H NMR (400 MHz, i.e6-DMSO) δ ppm 8.89 (s, 1H), 8.43 (d, 1H), 7.97-7.93 (m, 1H), 7.59 (d, 1H), 7.46-7.38 (m, 4H), 7.01 (m, 1H) , 4.52-4.45 (m, 1H), 4.02-3.97 (m, 1H), 3.59-3.54 (dd, 1H), 2.89-2.82 (dd, 1H), 2.45-2.38 (dd, 1H). Example No. I.4-34:1H NMR (400 MHz, d6-DMSO) δ ppm 9.26 (s, 1H), 8.93 (br. m, 1H), 7.68-7.65 (m, 2H), 7.58 (m, 1H), 7.40-7.34 (m , 2H), 7.17-7.10 (m, 2H), 6.80 (d, 1H), 4.52-4.45 (m, 1H), 4.21-4.16 (m, 1H), 3.76-3.72 (dd, 1H), 3.01-2.94 (dd, 1H), 2.49-2.43 (m, 1H), 2.32 (s, 3H). Example No. I.4-37:1H NMR (400 MHz, d6-DMSO) δ ppm 9.35 (s, 1H), 8.84 (br. m, 1H), 7.63-7.59 (m, 1H), 7.50 (d, 2H), 7.20-7.13 (m , 3H), 6.84 (d, 1H), 4.48-4.43 (m, 1H), 4.18-4.13 (m, 1H), 3.72-3.68 (dd, 1H), 2.98-2.92 (dd, 1H), 2.49-2.43 (m, 1H), 2.35 (s, 3H), 2.28 (s, 3H). Example No. I.4-38:1H NMR (400 MHz, d6-DMSO) δ ppm 8.59 (br. s, 1H, NH), 7.55 (d, 2H), 7.42 (d, 2H), 7.29 (d, 2H), 6.96 (d, 2H ), 6.81 (br. d, 1H, NH), 4.40-4.37 (m, 1H), 4.14-4.08 (m, 1H), 3.75 (s, 3H), 3.65-3.61 (dd, 1H), 2.92-2.85 (dd, 1H), 2.45-2.39 (dd, 1H). Example No. I.4-41:1H NMR (400 MHz, d6-DMSO) δ ppm 8.18 (d, 1H), 8.00 (br. s, 1H, NH), 7.64 (d, 1H), 7.58 (d, 2H), 7.42 (d, 1H ), 7.25 (m, 1H), 6.99-6.90 (m, 3H), 4.40-4.37 (m, 1H), 4.17-4.11 (m, 1H), 3.75 (s, 3H), 3.65-3.61 (dd, 1H ), 2.97-2.90 (dd, 1H), 2.39-2.34 (dd, 1H). b)1H NMR peak list method: Each signal peak is at1H NMR peak listing method first the δ value in ppm and then the signal intensity in round brackets. The δ value - signal intensity number pairs of different signal peaks are listed separated by semicolons. The peak list of an example therefore has the form: δ1 (intensity1); δ2 (intensity2);……..; δi (intensityi);……; δn (intensitiesn) The intensity of sharp signals correlates with the height of the signals in a printed example of an NMR spectrum in cm and shows the true ratios of the signal intensities. For broad signals, multiple peaks or the center of the signal and their relative intensity compared to the most intense signal in the spectrum can be shown. To calibrate the chemical shift of1H-NMR spectra use tetramethylsilane and/or solvent chemical shift, especially in the case of spectra measured in DMSO. The tetramethylsilane peak can therefore appear in NMR peak lists, but it does not have to. The lists of1H NMR peaks are similar to classic 1H NMR plots and thus usually include all peaks listed in a classic NMR interpretation. In addition, like classical 1H-NMR printouts, they can show signals from solvents, signals from stereoisomers of the target compounds, which are also the subject of the invention, and/or peaks from impurities. When reporting compound signals in the delta region of solvents and/or water, our lists of 1H NMR peaks are the usual solvent peaks, for example peaks from DMSO in DMSO-D6 and the peak of water, which usually have high intensity on average. The peaks of stereoisomers of the target compounds and/or peaks of impurities usually have on average a lower intensity than the peaks of the target compounds (e.g. with a purity of >90%). Such stereoisomers and/or impurities can be typical of the particular production process. Their peaks can thus help identify the reproduction of our manufacturing process using “by-product fingerprints”. An expert who calculates the peaks of the target compounds with known methods (MestreC, ACD simulation, but also with empirically evaluated expected values) can isolate the peaks of the target compounds as required, with additional intensity filters being used if necessary. This isolation would be similar to the peak picking involved in classical 1H NMR interpretation. More details about1H NMR peak lists can be found in Research Disclosure Database Number 564025. I.1-001:1H NMR (400.0MHz, d6-DMSO): δ= 7.5273 (2.0); 7.5223 (2.0); 7.5084 (3.3); 7.5029 (3.8); 7.4915 (2.3); 7.4850 (2.1); 7.2549 (0.9); 7.2500 (1.3); 7.2354 (3.2); 7.2306 (2.6); 7.2210 (4.2); 7.2169 (11.7); 7.1976 (6.6); 7.1784 (1.9); 4.7268 (3.0); 4.6869 (3.5); 4.2494 (3.9); 4.2092 (3.3); 3.7943 (0.8); 3.7839 (1.2); 3.7730 (1.8); 3.7635 (2.0); 3.7532 (1.8); 3.7426 (1.4); 3.7323 (0.5); 3.3770 (8.7); 3.1663 (3.3); 2.7741 (0.6); 2.7116 (3.2); 2.7014 (3.2); 2.6717 (4.3); 2.6615 (4.0); 2.5239 (2.2); 2.5192 (3.2); 2.5105 (50.3); 2.5059 (111.3); 2.5013 (155.7); 2.4967 (108.8); 2.4921 (48.1); 2.4468 (1.3); 2.4301 (1.1); 2.4057 (6.4); 2.3889 (2.1); 2.3835 (5.6); 2.3658 (4.0); 2.3517 (0.7); 2.3437 (3.4); 2.3328 (0.7); 2.3280 (1.0); 2.3234 (0.7); 2.2930 (1.5); 2.2801 (1.6); 2.2685 (2.8); 2.2557 (2.7); 2.2269 (3.6); 2.2171 (2.2); 2.2045 (1.4); 2.1993 (1.2); 2.1869 (1.8); 2.1803 (0.9); 2.1746 (0.7); 2.1677 (1.2); 2.1620 (1.0); 2.1432 (0.6); 1.7575 (1.7); 1.7466 (1.7); 1.7357 (1.9); 1.7284 (1.0); 1.7228 (1.0); 1.7180 (1.1); 1.7039 (1.1); 1.6914 (0.8); 1.6346 (0.6); 1.6181 (0.8); 1.6008 (0.6); 1.4445 (0.9); 1.4247 (1.2); 1.4052 (1.2); 1.3877 (0.7); 0.8894 (16.0); 0.8729 (15.3); -0.0002 (15.0). I.1-002:1H NMR (400.1 MHz, d6-DMSO): δ= 12.5234 (0.5); 12.4463 (0.6); 12.4011 (0.6); 12.3590 (0.6); 12.3360 (0.6); 12.3258 (0.6); 12.2780 (0.7); 12.1966 (0.5); 12.1506 (0.6); 12.1440 (0.7); 12.0718 (0.6); 11.9413 (0.6); 7.8181 (1.0); 7.3820 (2.6); 7.3781 (2.8); 7.3614 (5.7); 7.3576 (6.4); 7.3516 (3.8); 7.3354 (6.3); 7.3318 (5.8); 7.3157 (3.7); 7.3111 (3.4); 7.2096 (2.9); 7.2057 (3.4); 7.1967 (3.7); 7.1897 (6.5); 7.1858 (6.7); 7.1770 (6.4); 7.1734 (7.0); 7.1693 (4.9); 7.1654 (4.3); 7.1564 (3.9); 7.1531 (4.1); 7.1289 (0.6); 7.0951 (6.4); 7.0791 (8.9); 7.0600 (4.8); 7.0447 (0.9); 4.7423 (9.6); 4.7028 (11.4); 4.6780 (0.5); 4.2544 (12.5); 4.2148 (10.8); 3.8881 (0.5); 3.7898 (2.2); 3.7796 (4.0); 3.7687 (5.6); 3.7581 (6.4); 3.7484 (5.9); 3.7379 (4.7); 3.7278 (2.4); 3.6940 (0.7); 3.6517 (0.6); 3.6114 (0.7); 3.5977 (3.7); 3.5672 (0.9); 3.5600 (1.0); 3.5540 (1.1); 3.5249 (1.3); 3.5026 (1.4); 3.3613 (79.3); 3.1682 (10.0); 3.1265 (0.8); 3.1082 (0.8); 3.0944 (0.8); 3.0342 (0.6); 2.9971 (0.6); 2.7039 (9.7); 2.6935 (9.8); 2.6743 (4.0); 2.6698 (5.5); 2.6642 (14.6); 2.6538 (12.4); 2.5566 (2.4); 2.5520 (2.6); 2.5472 (1.4); 2.5398 (2.5); 2.5232 (7.9); 2.5185 (11.8); 2.5099 (249.1); 2.5053 (560.3); 2.5007 (795.0); 2.4961 (586.7); 2.4916 (296.0); 2.4499 (7.0); 2.4287 (5.2); 2.4192 (4.3); 2.4042 (10.1); 2.4007 (16.0); 2.3876 (7.2); 2.3788 (15.7); 2.3724 (4.6); 2.3609 (12.0); 2.3520 (2.9); 2.3388 (11.3); 2.3323 (4.7); 2.3274 (5.6); 2.3232 (4.1); 2.3185 (2.5); 2.2891 (5.3); 2.2761 (5.7); 2.2646 (8.5); 2.2516 (9.1); 2.2366 (1.7); 2.2205 (8.2); 2.2116 (6.6); 2.2067 (5.9); 2.1966 (5.3); 2.1914 (4.4); 2.1859 (3.1); 2.1791 (6.2); 2.1721 (3.4); 2.1663 (2.6); 2.1594 (4.1); 2.1537 (3.7); 2.1346 (2.1); 2.0720 (4.0); 1.8683 (0.7); 1.7841 (1.0); 1.7612 (2.6); 1.7562 (5.6); 1.7451 (5.6); 1.7328 (6.1); 1.7268 (3.6); 1.7212 (3.5); 1.7149 (4.2); 1.7023 (3.7); 1.6901 (2.5); 1.2552 (0.6); 0.9771 (0.6); 0.0082 (3.3) I.1-003:1H NMR (400.0MHz, d6-DMSO): δ= 12.3726 (10.8); 7.3860 (2.9); 7.3820 (3.1); 7.3656 (6.0); 7.3615 (6.6); 7.3554 (3.4); 7.3458 (4.3); 7.3395 (6.5); 7.3354 (5.7); 7.3193 (3.6); 7.3153 (3.4); 7.2112 (4.0); 7.2073 (4.3); 7.1985 (4.1); 7.1946 (4.9); 7.1913 (7.5); 7.1875 (8.0); 7.1785 (7.3); 7.1750 (8.2); 7.1710 (5.1); 7.1670 (5.0); 7.1582 (4.3); 7.1545 (4.7); 7.0958 (7.8); 7.0799 (10.5); 7.0765 (9.7); 7.0604 (5.4); 4.7435 (12.3); 4.7039 (14.3); 4.2546 (16.0); 4.2150 (13.8); 3.7886 (2.6); 3.7781 (4.9); 3.7672 (6.9); 3.7572 (7.4); 3.7472 (6.8); 3.7367 (5.4); 3.7261 (2.2); 3.3520 (1.4); 3.3265 (262.8); 3.2764 (1.3); 2.7083 (13.1); 2.6981 (13.3); 2.6756 (1.7); 2.6684 (17.1); 2.6582 (16.1); 2.5414 (0.6); 2.5246 (2.6); 2.5199 (4.1); 2.5112 (54.6); 2.5066 (116.9); 2.5020 (160.6); 2.4974 (109.1); 2.4928 (47.5); 2.4478 (3.6); 2.4304 (4.2); 2.4210 (2.6); 2.4064 (10.6); 2.4021 (19.0); 2.3892 (7.7); 2.3801 (19.3); 2.3723 (3.8); 2.3622 (14.6); 2.3508 (1.9); 2.3402 (14.1); 2.3289 (1.6); 2.3242 (1.1); 2.3197 (0.6); 2.2899 (6.2); 2.2770 (6.9); 2.2655 (11.3); 2.2526 (11.0); 2.2374 (1.1); 2.2241 (9.0); 2.2209 (9.6); 2.2188 (9.2); 2.2129 (6.6); 2.2103 (6.2); 2.2069 (6.6); 2.1965 (5.9); 2.1909 (4.6); 2.1858 (2.6); 2.1787 (7.2); 2.1721 (3.7); 2.1665 (2.6); 2.1594 (4.7); 2.1533 (4.2); 2.1350 (2.4); 2.0748 (0.8); 1.7822 (1.1); 1.7601 (3.1); 1.7543 (7.0); 1.7431 (7.2); 1.7355 (4.6); 1.7301 (7.2); 1.7250 (4.2); 1.7194 (4.0); 1.7136 (5.0); 1.7005 (4.4); 1.6878 (2.9); 0.0080 (1.6); 0.0063 (0.5); 0.0055 (0.6); 0.0047 (0.7); 0.0039 (0.8); 0.0022 (2.2); -0.0002 (53.4); -0.0051 (1.0); -0.0059 (0.7); -0.0068 (0.6); -0.0085 (1.6) I.1-004:1H NMR (400.1 MHz, d6-DMSO): δ= 11.1978 (0.8); 7.3828 (0.5); 7.3780 (0.4); 7.3621 (1.2); 7.3577 (1.1); 7.3414 (1.2); 7.3370 (1.3); 7.3163 (0.7); 7.2178 (0.3); 7.2142 (0.4); 7.2056 (0.7); 7.1942 (1.1); 7.1858 (1.4); 7.1774 (1.2); 7.1738 (1.3); 7.1653 (0.9); 7.1532 (0.6); 7.0797 (1.4); 7.0636 (0.7); 4.7699 (1.0); 4.7432 (1.3); 4.7300 (1.2); 4.7031 (1.4); 4.3015 (1.2); 4.2554 (1.8); 4.2153 (1.4); 3.9266 (0.4); 3.9162 (0.5); 3.9053 (0.6); 3.8949 (0.6); 3.8846 (0.4); 3.8383 (16.0); 3.7797 (0.5); 3.7701 (0.8); 3.7600 (0.9); 3.7491 (0.8); 3.7392 (0.6); 3.3704 (18.0); 3.1686 (1.1); 2.9541 (0.6); 2.9442 (0.6); 2.9160 (0.8); 2.9060 (0.7); 2.7041 (1.2); 2.6938 (1.2); 2.6747 (0.5); 2.6699 (0.7); 2.6645 (1.8); 2.6540 (1.6); 2.6354 (0.7); 2.6128 (0.7); 2.5970 (0.6); 2.5747 (0.7); 2.5616 (0.6); 2.5576 (0.6); 2.5530 (0.4); 2.5234 (1.0); 2.5185 (1.7); 2.5101 (31.6); 2.5055 (68.7); 2.5009 (96.0); 2.4964 (70.2); 2.4919 (35.2); 2.4548 (1.0); 2.4497 (1.2); 2.4457 (1.3); 2.4315 (1.2); 2.4141 (1.1); 2.4060 (1.6); 2.4012 (2.0); 2.3887 (1.1); 2.3792 (2.0); 2.3736 (0.7); 2.3611 (1.5); 2.3509 (0.4); 2.3391 (1.4); 2.3328 (1.0); 2.3277 (0.8); 2.3201 (0.7); 2.3085 (0.8); 2.2962 (0.8); 2.2898 (0.8); 2.2765 (0.7); 2.2649 (1.4); 2.2520 (1.3); 2.2481 (1.0); 2.2352 (0.6); 2.2206 (1.3); 2.2119 (1.1); 2.1969 (1.0); 2.1918 (0.9); 2.1788 (0.8); 2.1723 (0.6); 2.1664 (0.4); 2.1604 (0.5); 2.1544 (0.5); 1.8706 (0.4); 1.8587 (0.5); 1.8479 (0.5); 1.8428 (0.5); 1.8363 (0.4); 1.8293 (0.4); 1.8166 (0.3); 1.7621 (0.3); 1.7568 (0.7); 1.7458 (0.7); 1.7329 (0.8); 1.7275 (0.5); 1.7218 (0.4); 1.7157 (0.5); 1.7030 (0.5); 0.0082 (0.5); 0.0000 (17.0) I.1-005:1H NMR (400.1 MHz, d6-DMSO): δ= 8.1838 (0.6); 8.1628 (0.7); 8.1443 (0.5); 8.1236 (0.5); 8.1049 (1.0); 8.0829 (1.1); 7.3769 (0.6); 7.3571 (1.3); 7.3337 (1.3); 7.3113 (0.7); 7.2067 (0.6); 7.1868 (1.4); 7.1742 (1.4); 7.1538 (0.7); 7.0893 (1.0); 7.0733 (1.6); 7.0571 (0.8); 4.7542 (1.4); 4.7372 (0.6); 4.7145 (1.6); 4.6965 (0.8); 4.3978 (1.0); 4.3862 (1.0); 4.3755 (1.0); 4.3640 (1.0); 4.2659 (1.2); 4.2543 (0.9); 4.2457 (0.8); 4.2265 (1.1); 4.2195 (1.0); 4.2050 (1.3); 4.1985 (0.8); 4.1836 (0.6); 4.1675 (0.5); 4.1527 (0.6); 4.1467 (0.5); 4.1318 (0.5); 3.8003 (0.4); 3.7906 (0.7); 3.7806 (1.1); 3.7709 (1.4); 3.7608 (1.2); 3.7502 (0.8); 3.7389 (0.4); 3.3617 (31.2); 3.1683 (2.1); 2.6743 (0.6); 2.6696 (0.8); 2.6650 (0.6); 2.6604 (0.4); 2.6315 (0.4); 2.6210 (0.5); 2.5958 (1.0); 2.5849 (1.4); 2.5742 (0.6); 2.5613 (1.1); 2.5507 (1.4); 2.5399 (1.2); 2.5232 (1.7); 2.5184 (2.7); 2.5098 (44.8); 2.5052 (98.6); 2.5006 (137.4); 2.4960 (99.7); 2.4914 (46.7); 2.4071 (0.5); 2.3998 (1.2); 2.3833 (0.8); 2.3784 (1.3); 2.3657 (2.0); 2.3447 (1.9); 2.3359 (1.4); 2.3322 (1.2); 2.3275 (1.3); 2.3229 (1.5); 2.3150 (1.1); 2.2934 (0.6); 2.2869 (0.5); 2.2786 (1.0); 2.2627 (1.1); 2.2540 (1.1); 2.2509 (1.1); 2.2412 (0.9); 2.2212 (0.5); 2.2096 (0.6); 2.1994 (0.5); 2.1249 (0.4); 2.1047 (0.9); 2.0927 (0.7); 2.0808 (0.9); 2.0723 (1.5); 2.0616 (0.5); 2.0524 (0.8); 2.0491 (0.9); 2.0295 (0.4); 1.8690 (0.6); 1.8571 (0.6); 1.8515 (0.7); 1.8399 (0.6); 1.8335 (0.5); 1.8224 (0.5); 1.8029 (0.6); 1.7945 (0.9); 1.7803 (1.0); 1.7709 (1.1); 1.7607 (1.1); 1.7533 (0.9); 1.7431 (0.8); 1.7294 (0.5); 1.3818 (0.5); 1.3644 (0.4); 1.3582 (0.3); 1.2949 (0.4); 1.2771 (0.6); 1.2600 (0.8); 1.2428 (0.9); 1.2249 (0.7); 1.2073 (0.4); 1.1887 (0.5); 1.1760 (0.5); 1.1694 (0.5); 1.1588 (0.8); 1.1540 (0.6); 1.1408 (0.9); 1.1354 (0.6); 1.1233 (0.7); 1.1066 (0.6); 1.0887 (0.4); 0.8483 (13.7); 0.8336 (16.0); 0.8313 (15.8); 0.8153 (4.9); 0.0082 (0.9) I.1-006:1H NMR (400.0MHz, d6-DMSO): δ= 7.3863 (1.5); 7.3823 (1.6); 7.3659 (3.0); 7.3617 (3.4); 7.3556 (1.7); 7.3461 (2.1); 7.3399 (3.3); 7.3357 (2.8); 7.3196 (1.8); 7.3156 (1.7); 7.2075 (1.8); 7.2037 (1.9); 7.1949 (1.9); 7.1911 (2.2); 7.1877 (3.4); 7.1840 (3.6); 7.1750 (3.4); 7.1715 (3.8); 7.1673 (2.3); 7.1635 (2.3); 7.1546 (2.0); 7.1512 (2.2); 7.1089 (3.6); 7.0930 (4.6); 7.0736 (2.3); 4.7514 (5.2); 4.7118 (6.0); 4.2748 (6.7); 4.2351 (5.7); 3.8544 (1.1); 3.8441 (2.1); 3.8339 (3.4); 3.8239 (4.0); 3.8138 (3.4); 3.8037 (2.6); 3.7930 (0.9); 3.4628 (15.4); 3.1689 (0.6); 2.8932 (5.3); 2.8829 (5.5); 2.8533 (7.2); 2.8431 (6.8); 2.6710 (0.5); 2.6664 (0.5); 2.6456 (7.4); 2.6245 (7.2); 2.6058 (5.8); 2.5847 (5.6); 2.5245 (1.2); 2.5197 (1.8); 2.5111 (30.4); 2.5065 (66.8); 2.5019 (93.7); 2.4972 (65.1); 2.4926 (28.7); 2.4590 (1.8); 2.4470 (4.5); 2.4406 (6.1); 2.4313 (9.6); 2.4180 (8.0); 2.4005 (3.4); 2.3949 (2.9); 2.3797 (1.5); 2.3648 (1.0); 2.3287 (0.6); 2.3004 (2.5); 2.2881 (2.8); 2.2758 (5.6); 2.2699 (7.5); 2.2637 (7.0); 2.2547 (10.3); 2.2383 (10.3); 2.2353 (10.2); 2.2289 (3.2); 2.2250 (4.9); 2.2156 (2.7); 2.2096 (2.1); 2.2045 (1.1); 2.1975 (3.3); 2.1912 (1.4); 2.1851 (1.1); 2.1782 (2.0); 2.1725 (1.8); 2.1537 (1.0); 2.0740 (3.4); 1.8160 (0.8); 1.7919 (3.1); 1.7803 (2.4); 1.7703 (2.8); 1.7626 (1.8); 1.7576 (1.8); 1.7535 (1.8); 1.7489 (2.0); 1.7381 (2.0); 1.7263 (1.3); 1.6501 (4.9); 1.5712 (13.8); 1.5641 (16.0); 1.5558 (11.3); -0.0002 (7.0) I.1-009:1H NMR (400.1 MHz, d6-DMSO): δ= 7.3860 (0.3); 7.3818 (0.4); 7.3654 (0.8); 7.3615 (0.8); 7.3556 (0.4); 7.3456 (0.5); 7.3395 (0.8); 7.3356 (0.7); 7.3192 (0.4); 7.3153 (0.4); 7.2123 (0.4); 7.2086 (0.4); 7.1996 (0.5); 7.1957 (0.6); 7.1924 (0.8); 7.1888 (0.9); 7.1796 (0.8); 7.1764 (0.9); 7.1723 (0.6); 7.1684 (0.6); 7.1595 (0.5); 7.1559 (0.5); 7.0953 (0.9); 7.0793 (1.2); 7.0764 (1.1); 7.0600 (0.6); 4.7406 (1.3); 4.7009 (1.6); 4.3621 (2.5); 4.3560 (0.6); 4.3474 (5.0); 4.3389 (0.7); 4.3328 (2.8); 4.2515 (1.7); 4.2119 (1.5); 3.8177 (0.5); 3.8073 (0.8); 3.7971 (0.9); 3.7872 (0.9); 3.7768 (0.6); 3.4789 (2.0); 3.4645 (3.4); 3.4499 (1.9); 3.3678 (10.0); 3.1687 (0.4); 2.9991 (16.0); 2.8276 (1.2); 2.8176 (1.2); 2.7875 (1.6); 2.7774 (1.5); 2.5588 (1.6); 2.5370 (1.6); 2.5186 (1.8); 2.5099 (10.4); 2.5053 (23.0); 2.5007 (32.8); 2.4962 (24.9); 2.4916 (11.6); 2.4522 (0.4); 2.4349 (0.5); 2.4113 (1.0); 2.3936 (0.8); 2.3878 (0.7); 2.3809 (0.3); 2.3722 (0.4); 2.2921 (0.6); 2.2798 (0.6); 2.2677 (1.1); 2.2554 (1.1); 2.2263 (1.8); 2.2161 (1.1); 2.2060 (0.6); 2.2003 (0.5); 2.1878 (0.8); 2.1817 (0.4); 2.1686 (0.5); 2.1629 (0.5); 1.7810 (0.7); 1.7697 (0.6); 1.7594 (0.8); 1.7516 (0.4); 1.7467 (0.4); 1.7421 (0.4); 1.7380 (0.5); 1.7269 (0.5); 0.0000 (9.4) I.1-011:1H NMR (400.1 MHz, i.e6-DMSO): δ= 19.7585 (0.3); 12.9496 (0.4); 12.6612 (0.4); 12.5714 (0.8); 12.5551 (0.6); 12.5285 (0.4); 8.1442 (0.6); 8.1255 (0.6); 8.1082 (0.4); 8.0797 (0.4); 8.0598 (1.4); 8.0365 (1.4); 7.9568 (0.6); 7.4617 (0.3); 7.3773 (0.7); 7.3549 (1.6); 7.3320 (1.6); 7.3094 (0.8); 7.2253 (0.4); 7.1847 (1.5); 7.1715 (1.6); 7.1543 (0.9); 7.0750 (1.9); 4.7539 (0.8); 4.7385 (1.7); 4.7121 (0.7); 4.6979 (1.9); 4.3971 (0.4); 4.3747 (0.4); 4.3452 (1.2); 4.3342 (1.3); 4.3244 (1.2); 4.3128 (1.1); 4.2488 (2.0); 4.2092 (2.0); 4.1683 (0.5); 4.1504 (0.6); 4.1304 (0.4); 4.0761 (0.6); 3.9659 (0.5); 3.9032 (0.3); 3.7811 (1.3); 3.7684 (1.7); 3.6533 (0.3); 3.6104 (0.4); 3.5831 (0.4); 3.5679 (0.5); 3.5390 (0.5); 3.5012 (0.6); 3.4888 (0.7); 3.4613 (0.8); 3.4216 (1.2); 3.3747 (2.8); 3.3178 (191.6); 3.2190 (1.5); 3.1907 (0.9); 3.1759 (2.8); 3.1633 (2.9); 3.1011 (0.3); 3.0923 (0.3); 3.0484 (0.3); 2.9989 (0.4); 2.8911 (4.6); 2.8794 (0.5); 2.8416 (0.4); 2.8290 (0.4); 2.7752 (0.4); 2.7315 (4.7); 2.6721 (3.3); 2.6460 (1.8); 2.6206 (2.3); 2.6130 (2.3); 2.5645 (2.6); 2.5030 (519.5); 2.3986 (2.3); 2.3764 (1.8); 2.3346 (4.2); 2.3020 (1.4); 2.2788 (1.8); 2.2605 (1.4); 2.2543 (1.4); 2.2229 (0.8); 2.1244 (0.5); 2.1025 (0.9); 2.0801 (1.2); 2.0721 (2.0); 2.0494 (1.0); 2.0274 (0.5); 1.8307 (1.2); 1.8156 (1.2); 1.7988 (1.3); 1.7776 (1.1); 1.7098 (0.3); 1.3822 (0.4); 1.3629 (0.4); 1.3493 (0.3); 1.2934 (0.5); 1.2783 (0.8); 1.2600 (0.9); 1.2433 (1.2); 1.2245 (0.8); 1.2092 (0.5); 1.1876 (0.4); 1.1534 (0.8); 1.1343 (1.1); 1.1167 (1.0); 1.0996 (0.8); 1.0820 (0.5); 0.8481 (12.7); 0.8318 (16.0); 0.8156 (4.6); 0.7823 (0.5); 0.1461 (0.5); 0.0081 (4.3); 0.0000 (107.5) I.1-012:1H NMR (400.1 MHz, CDCl3): δ= 7.2629 (13.1); 7.2610 (25.7); 7.1145 (0.4); 7.1026 (0.7); 7.0933 (0.4); 7.0853 (0.7); 7.0780 (0.8); 7.0739 (0.4); 7.0679 (0.4); 7.0594 (2.7); 7.0527 (1.5); 7.0491 (2.4); 7.0407 (0.9); 7.0354 (0.8); 4.8904 (1.0); 4.8871 (1.0); 4.8516 (1.2); 4.8483 (1.1); 4.2618 (1.5); 4.2230 (1.4); 3.9047 (0.5); 3.8944 (0.6); 3.8841 (0.8); 3.8736 (0.7); 3.8632 (0.5); 3.6680 (16.0); 2.7366 (1.0); 2.7264 (1.0); 2.6978 (1.3); 2.6875 (1.2); 2.5364 (0.3); 2.5119 (0.8); 2.4935 (0.7); 2.4877 (0.6); 2.4697 (0.6); 2.4376 (1.8); 2.4238 (0.8); 2.4152 (1.9); 2.3990 (1.8); 2.3765 (1.0); 2.3709 (0.5); 2.3570 (0.5); 2.3170 (0.4); 2.2989 (0.6); 2.2847 (0.4); 2.2793 (0.4); 2.2746 (0.4); 2.2664 (0.6); 2.2602 (0.4); 2.2466 (0.4); 2.2420 (0.4); 1.8760 (0.3); 1.8646 (0.5); 1.8519 (0.6); 1.8432 (0.5); 1.8407 (0.5); 1.8382 (0.4); 1.8320 (0.5); 1.8295 (0.4); 1.8268 (0.4); 1.8194 (0.5); 1.8080 (0.4); 1.5711 (5.5); 0.0019 (4.0) I.1-014:1H NMR (400.0 MHz, i.e6-DMSO): δ= 12.3682 (1.9); 7.3838 (3.5); 7.3798 (3.8); 7.3634 (7.2); 7.3593 (8.0); 7.3532 (4.1); 7.3437 (5.1); 7.3373 (7.7); 7.3332 (6.6); 7.3173 (4.4); 7.3133 (4.1); 7.2101 (4.5); 7.2062 (4.6); 7.1974 (4.6); 7.1935 (5.5); 7.1902 (8.2); 7.1864 (8.7); 7.1776 (7.9); 7.1739 (9.0); 7.1699 (5.4); 7.1659 (5.4); 7.1572 (4.6); 7.1536 (4.9); 7.0954 (8.4); 7.0793 (11.4); 7.0598 (5.7); 4.7429 (12.5); 4.7028 (14.4); 4.2543 (16.0); 4.2147 (14.0); 3.7888 (2.8); 3.7783 (5.0); 3.7671 (7.2); 3.7574 (7.7); 3.7472 (7.1); 3.7368 (5.5); 3.7262 (2.2); 3.3181 (83.5); 2.7049 (13.3); 2.6947 (13.5); 2.6746 (2.9); 2.6702 (4.7); 2.6651 (18.9); 2.6548 (16.1); 2.5405 (1.3); 2.5238 (9.2); 2.5190 (13.3); 2.5104 (196.8); 2.5058 (432.4); 2.5012 (604.9); 2.4966 (419.9); 2.4920 (185.2); 2.4464 (4.5); 2.4293 (4.4); 2.4193 (2.7); 2.4049 (10.6); 2.3995 (19.2); 2.3879 (7.9); 2.3775 (18.6); 2.3652 (4.6); 2.3597 (14.8); 2.3500 (2.2); 2.3376 (15.2); 2.3280 (3.7); 2.3233 (2.9); 2.2890 (6.6); 2.2760 (7.2); 2.2645 (11.7); 2.2516 (11.2); 2.2231 (9.7); 2.2201 (9.8); 2.2117 (6.8); 2.2061 (6.5); 2.1959 (6.1); 2.1902 (4.8); 2.1780 (7.5); 2.1716 (3.8); 2.1655 (2.7); 2.1587 (5.0); 2.1525 (4.2); 2.1339 (2.4); 2.0734 (1.2); 1.7825 (1.1); 1.7604 (3.2); 1.7549 (7.3); 1.7435 (7.2); 1.7304 (7.2); 1.7256 (4.2); 1.7199 (4.1); 1.7142 (4.8); 1.7011 (4.4); 1.6885 (2.8); 0.1457 (0.9); 0.0080 (9.3); -0.0002 (333.6); -0.0060 (3.4); -0.0085 (9.7); -0.0338 (0.9); -0.1498 (0.9) I.1-015:1H NMR (400.1 MHz, d6-DMSO): δ= 7.3621 (0.5); 7.3583 (0.6); 7.3425 (0.3); 7.3368 (0.6); 7.3325 (0.5); 7.1893 (0.6); 7.1858 (0.6); 7.1765 (0.6); 7.1734 (0.6); 7.1655 (0.4); 7.1532 (0.3); 7.0942 (0.6); 7.0781 (0.8); 7.0590 (0.4); 4.7306 (1.0); 4.6908 (1.1); 4.2636 (1.2); 4.2238 (1.0); 4.1134 (1.6); 4.1039 (1.7); 4.1016 (1.6); 4.0901 (1.9); 3.8187 (0.4); 3.8087 (0.6); 3.7985 (0.7); 3.7884 (0.6); 3.7783 (0.4); 3.5540 (0.3); 3.5057 (2.6); 3.4861 (3.3); 3.4809 (1.6); 3.4743 (2.9); 3.4628 (2.4); 3.2326 (16.0); 2.7929 (0.8); 2.7823 (0.8); 2.7530 (1.1); 2.7425 (1.1); 2.5512 (0.9); 2.5304 (1.2); 2.5235 (0.4); 2.5101 (7.8); 2.5055 (15.5); 2.5010 (21.5); 2.4965 (15.7); 2.4919 (8.0); 2.4384 (0.4); 2.4144 (0.7); 2.3970 (0.6); 2.3908 (0.5); 2.2923 (0.4); 2.2796 (0.4); 2.2678 (0.7); 2.2551 (0.8); 2.2254 (0.9); 2.2155 (0.7); 2.2116 (0.5); 2.2013 (0.4); 2.1957 (0.3); 2.1831 (0.5); 2.1583 (0.3); 1.7654 (0.5); 1.7542 (0.5); 1.7423 (0.6); 1.7247 (0.3); 1.7112 (0.4); 0.0007 (2.6); 0.0000 (2.7) I.1-016:1H NMR (400.1 MHz, d6-DMSO): δ= 8.1813 (0.9); 8.1602 (0.9); 8.1024 (1.2); 8.0802 (1.2); 7.3760 (0.5); 7.3547 (1.2); 7.3328 (1.2); 7.3097 (0.6); 7.2067 (0.6); 7.1869 (1.3); 7.1744 (1.3); 7.1667 (0.8); 7.1541 (0.7); 7.0897 (1.0); 7.0739 (1.6); 7.0585 (0.8); 4.7547 (1.7); 4.7150 (2.0); 4.3988 (1.1); 4.3873 (1.2); 4.3766 (1.1); 4.3651 (1.2); 4.2672 (1.4); 4.2557 (1.1); 4.2276 (1.3); 4.2211 (1.3); 4.2168 (1.1); 4.2064 (1.2); 4.2000 (1.0); 4.1852 (0.9); 3.8011 (0.8); 3.7919 (1.1); 3.7826 (1.5); 3.7725 (1.8); 3.7626 (1.7); 3.7523 (1.4); 3.7412 (1.0); 2.5966 (0.9); 2.5858 (1.4); 2.5752 (0.7); 2.5624 (1.1); 2.5514 (1.9); 2.5408 (1.0); 2.5237 (0.4); 2.5190 (0.6); 2.5103 (12.4); 2.5058 (27.8); 2.5012 (39.6); 2.4966 (28.8); 2.4920 (13.8); 2.4567 (0.3); 2.4078 (0.6); 2.4012 (1.2); 2.3845 (0.9); 2.3799 (1.3); 2.3668 (2.2); 2.3461 (2.2); 2.3374 (1.0); 2.3236 (1.2); 2.3161 (0.8); 2.2785 (0.7); 2.2759 (0.7); 2.2656 (0.8); 2.2631 (0.8); 2.2546 (1.0); 2.2515 (0.9); 2.2415 (1.0); 2.2386 (1.0); 2.2241 (0.5); 2.2213 (0.4); 2.2128 (0.6); 2.2098 (0.5); 2.1999 (0.6); 2.1260 (0.4); 2.1058 (0.8); 2.0942 (0.6); 2.0849 (0.7); 2.0823 (0.7); 2.0745 (1.0); 2.0722 (1.1); 2.0625 (0.4); 2.0538 (0.8); 1.8697 (0.6); 1.8581 (0.6); 1.8523 (0.6); 1.8407 (0.6); 1.8353 (0.4); 1.8232 (0.4); 1.8097 (0.4); 1.8056 (0.5); 1.7966 (0.8); 1.7862 (0.8); 1.7827 (0.9); 1.7729 (1.1); 1.7633 (1.1); 1.7552 (1.0); 1.7517 (0.9); 1.7445 (0.8); 1.7408 (0.8); 1.7295 (0.5); 1.3826 (0.4); 1.3785 (0.4); 1.3672 (0.4); 1.3594 (0.4); 1.3490 (0.3); 1.2969 (0.3); 1.2789 (0.6); 1.2620 (0.7); 1.2446 (0.8); 1.2266 (0.6); 1.2107 (0.4); 1.1928 (0.4); 1.1893 (0.4); 1.1774 (0.4); 1.1705 (0.5); 1.1596 (0.8); 1.1416 (1.0); 1.1238 (0.8); 1.1074 (0.6); 1.0894 (0.4); 0.8493 (11.9); 0.8343 (16.0); 0.8161 (4.9) I.1-017:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.3831 (2.0); 7.3792 (2.1); 7.3627 (4.0); 7.3586 (4.4); 7.3526 (2.3); 7.3429 (2.8); 7.3368 (4.3); 7.3325 (3.7); 7.3164 (2.3); 7.3124 (2.1); 7.2081 (2.6); 7.2041 (2.7); 7.1954 (2.6); 7.1914 (3.1); 7.1882 (4.6); 7.1844 (4.9); 7.1755 (4.5); 7.1719 (5.0); 7.1678 (3.0); 7.1638 (2.9); 7.1551 (2.5); 7.1514 (2.9); 7.0874 (4.7); 7.0715 (6.3); 7.0680 (5.7); 7.0520 (3.2); 6.1735 (0.9); 5.0416 (1.8); 5.0346 (3.7); 5.0254 (4.3); 5.0185 (5.9); 5.0117 (3.6); 5.0032 (3.4); 4.7163 (7.1); 4.6765 (8.3); 4.2594 (9.4); 4.2195 (8.0); 3.8187 (1.7); 3.8077 (3.2); 3.7985 (4.4); 3.7878 (6.2); 3.7778 (4.0); 3.7679 (3.4); 3.7570 (1.4); 3.5345 (16.0); 3.1684 (3.0); 2.7094 (7.7); 2.6986 (7.9); 2.6699 (12.2); 2.6591 (10.5); 2.6003 (0.5); 2.5956 (0.5); 2.5612 (0.8); 2.5567 (1.2); 2.5521 (1.3); 2.5474 (0.6); 2.5237 (2.5); 2.5189 (3.8); 2.5103 (67.7); 2.5057 (147.2); 2.5010 (206.5); 2.4964 (148.4); 2.4918 (69.8); 2.4738 (11.6); 2.4544 (6.4); 2.4344 (9.9); 2.4166 (2.2); 2.4078 (1.4); 2.3927 (5.3); 2.3751 (4.3); 2.3691 (3.8); 2.3532 (2.6); 2.3370 (0.6); 2.3325 (1.5); 2.3279 (1.4); 2.3232 (1.0); 2.2980 (3.9); 2.2846 (4.5); 2.2735 (6.8); 2.2602 (6.8); 2.2442 (0.7); 2.2320 (4.4); 2.2239 (6.7); 2.2200 (3.4); 2.2109 (2.9); 2.2080 (3.6); 2.1973 (3.5); 2.1914 (2.7); 2.1866 (1.6); 2.1834 (1.9); 2.1796 (3.9); 2.1728 (2.2); 2.1669 (1.6); 2.1598 (2.7); 2.1533 (2.4); 2.1353 (1.5); 2.0727 (1.1); 1.8271 (0.8); 1.8115 (2.1); 1.8020 (3.0); 1.7880 (5.5); 1.7768 (5.5); 1.7727 (5.8); 1.7651 (5.0); 1.7568 (7.5); 1.7451 (6.3); 1.7380 (3.6); 1.7340 (4.1); 1.7323 (4.1); 1.7287 (3.8); 1.7209 (2.7); 1.7144 (3.9); 1.7025 (2.6); 1.6892 (1.7); 1.6451 (0.6); 1.6320 (1.0); 1.6262 (1.4); 1.6152 (2.6); 1.6037 (4.2); 1.5947 (6.5); 1.5857 (4.9); 1.5832 (4.9); 1.5796 (4.5); 1.5732 (5.5); 1.5667 (4.3); 1.5637 (5.0); 1.5548 (7.4); 1.5442 (12.8); 1.5355 (8.9); 1.5300 (10.2); 1.5219 (9.2); 1.5174 (10.4); 1.5125 (9.2); 1.5072 (7.5); 1.5010 (5.7); 1.4967 (4.2); 1.4877 (2.7); 1.1950 (0.5); 1.1769 (1.1); 1.1586 (0.5); 0.0080 (1.4); -0.0002 (55.1); - 0.0085 (1.7) I.1-020:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.3835 (0.9); 7.3794 (0.9); 7.3630 (1.8); 7.3589 (2.0); 7.3529 (1.0); 7.3432 (1.2); 7.3370 (2.0); 7.3328 (1.7); 7.3168 (1.1); 7.3128 (1.0); 7.2114 (1.1); 7.2074 (1.2); 7.1987 (1.1); 7.1948 (1.3); 7.1915 (2.1); 7.1877 (2.2); 7.1788 (2.0); 7.1752 (2.2); 7.1711 (1.4); 7.1672 (1.4); 7.1584 (1.2); 7.1547 (1.3); 7.0971 (2.1); 7.0812 (2.8); 7.0777 (2.6); 7.0617 (1.5); 4.7325 (3.2); 4.6928 (3.8); 4.2733 (4.2); 4.2335 (3.6); 3.8378 (1.0); 3.8304 (15.1); 3.8123 (16.0); 3.7975 (2.0); 3.7873 (1.6); 3.7765 (0.6); 3.3106 (98.6); 3.2828 (0.6); 2.7797 (3.3); 2.7690 (3.3); 2.7400 (4.6); 2.7293 (4.4); 2.6700 (0.6); 2.5511 (0.6); 2.5454 (4.9); 2.5247 (5.3); 2.5189 (2.0); 2.5102 (31.1); 2.5056 (70.4); 2.5010 (92.7); 2.4963 (64.7); 2.4917 (29.4); 2.4852 (4.8); 2.4754 (0.5); 2.4569 (1.3); 2.4391 (0.9); 2.4295 (0.5); 2.4157 (2.4); 2.3983 (1.8); 2.3922 (1.6); 2.3836 (0.7); 2.3765 (0.8); 2.3278 (0.6); 2.2981 (1.7); 2.2853 (1.8); 2.2736 (3.0); 2.2609 (2.9); 2.2316 (3.5); 2.2219 (2.6); 2.2181 (1.9); 2.2084 (1.6); 2.2027 (1.3); 2.1976 (0.6); 2.1908 (1.9); 2.1838 (1.0); 2.1781 (0.7); 2.1712 (1.2); 2.1648 (1.0); 2.1466 (0.6); 2.0725 (0.6); 1.7778 (0.8); 1.7739 (1.9); 1.7628 (1.8); 1.7552 (1.2); 1.7513 (2.0); 1.7446 (1.1); 1.7391 (1.1); 1.7341 (1.2); 1.7314 (1.1); 1.7200 (1.2); 1.7075 (0.8); 1.0693 (0.6); 1.0629 (0.8); 1.0509 (1.6); 1.0494 (1.5); 1.0428 (1.4); 1.0391 (1.1); 1.0310 (3.0); 1.0229 (1.1); 1.0190 (1.5); 1.0126 (1.5); 1.0110 (1.8); 0.9991 (1.0); 0.9927 (0.7); 0.5139 (2.1); 0.5032 (6.3); 0.4987 (7.1); 0.4939 (2.8); 0.4881 (3.0); 0.4828 (7.2); 0.4785 (6.0); 0.4681 (2.6); 0.2467 (2.6); 0.2362 (7.3); 0.2322 (6.8); 0.2244 (6.2); 0.2205 (7.8); 0.2097 (1.8); -0.0002 (9.9) I.1-021:1H NMR (400.0MHz, d6-DMSO): δ= 7.3662 (0.7); 7.3621 (0.8); 7.3404 (0.8); 7.3360 (0.7); 7.1942 (0.5); 7.1909 (0.8); 7.1872 (0.8); 7.1782 (0.8); 7.1747 (0.9); 7.1706 (0.5); 7.1667 (0.5); 7.0968 (0.8); 7.0808 (1.1); 7.0775 (1.0); 7.0613 (0.6); 5.9130 (0.5); 5.8992 (1.1); 5.8866 (0.7); 5.8730 (1.3); 5.8700 (0.7); 5.8593 (0.6); 5.8561 (1.4); 5.8434 (0.8); 5.8427 (0.8); 5.8299 (1.4); 5.8162 (0.6); 5.3003 (0.7); 5.2962 (2.1); 5.2921 (2.2); 5.2880 (0.8); 5.2572 (0.6); 5.2531 (1.8); 5.2490 (1.9); 5.2449 (0.7); 5.2206 (0.8); 5.2172 (1.9); 5.2133 (1.8); 5.2099 (0.7); 5.1944 (0.7); 5.1910 (1.7); 5.1871 (1.7); 5.1837 (0.6); 4.7275 (1.2); 4.6877 (1.5); 4.5180 (2.3); 4.5143 (4.0); 4.5107 (2.4); 4.5042 (2.3); 4.5006 (3.9); 4.4969 (2.3); 4.2703 (1.6); 4.2305 (1.4); 3.8294 (0.5); 3.8192 (0.8); 3.8091 (1.0); 3.7991 (0.8); 3.7888 (0.6); 3.4612 (16.0); 2.8291 (1.3); 2.8185 (1.3); 2.7890 (1.7); 2.7784 (1.6); 2.5812 (1.8); 2.5602 (1.8); 2.5411 (1.4); 2.5202 (1.8); 2.5122 (10.8); 2.5077 (23.1); 2.5030 (31.8); 2.4984 (22.5); 2.4939 (10.3); 2.4157 (1.0); 2.3981 (0.8); 2.3922 (0.7); 2.2979 (0.6); 2.2852 (0.7); 2.2734 (1.2); 2.2607 (1.1); 2.2302 (1.1); 2.2277 (1.0); 2.2207 (0.8); 2.2161 (0.7); 2.2060 (0.6); 2.1881 (0.8); 1.7633 (0.7); 1.7522 (0.7); 1.7396 (0.8); -0.0002 (3.0) I.1-022:1H NMR (400.1 MHz, d6-DMSO): δ= 12.4106 (0.4); 12.3700 (0.4); 12.3632 (0.5); 12.3444 (0.5); 12.3338 (0.5); 12.3240 (0.5); 7.3860 (4.9); 7.3663 (13.8); 7.3481 (16.0); 7.3415 (7.3); 7.3370 (13.8); 7.3328 (10.6); 7.3217 (2.6); 7.3166 (5.1); 7.3129 (3.4); 7.2944 (15.5); 7.2037 (10.0); 7.1858 (8.1); 4.6615 (9.8); 4.6225 (11.4); 4.1613 (11.3); 4.1223 (9.8); 3.7632 (1.6); 3.7525 (3.3); 3.7417 (4.7); 3.7323 (4.8); 3.7212 (4.6); 3.7107 (3.7); 3.7001 (1.9); 3.4494 (1.5); 3.1704 (0.4); 2.7033 (7.3); 2.6934 (7.5); 2.6636 (9.3); 2.6536 (8.9); 2.5235 (0.6); 2.5101 (23.3); 2.5056 (51.5); 2.5011 (73.1); 2.4965 (53.5); 2.4920 (26.0); 2.4604 (0.4); 2.4502 (2.4); 2.4416 (0.7); 2.4324 (2.6); 2.4253 (2.6); 2.4084 (5.8); 2.3907 (4.5); 2.3846 (4.2); 2.3676 (4.0); 2.3419 (9.4); 2.3329 (1.0); 2.3193 (9.3); 2.3108 (4.5); 2.3022 (8.3); 2.2970 (5.3); 2.2864 (6.6); 2.2796 (8.3); 2.2725 (6.7); 2.2559 (1.7); 2.2447 (3.7); 2.2317 (4.1); 2.2152 (2.8); 2.1969 (3.5); 2.1911 (1.8); 2.1845 (3.1); 2.1790 (2.7); 2.1723 (2.6); 2.1661 (4.1); 2.1603 (2.6); 2.1547 (1.8); 2.1471 (2.7); 2.1412 (2.8); 2.1228 (1.6); 2.0720 (2.4); 1.7470 (2.0); 1.7350 (3.3); 1.7235 (4.1); 1.7160 (2.6); 1.7124 (3.3); 1.7041 (3.8); 1.6991 (2.6); 1.6919 (3.8); 1.6805 (2.5); 1.6672 (1.7) I.1-023:1H NMR (400.1 MHz, CDCl3): δ= 7.5210 (0.4); 7.3865 (5.6); 7.3669 (8.7); 7.3136 (4.4); 7.2954 (8.2); 7.2754 (4.8); 7.2620 (76.5); 7.2333 (3.1); 7.2148 (4.0); 7.1968 (1.3); 7.1220 (0.5); 7.1099 (1.0); 7.0976 (1.9); 7.0867 (1.3); 7.0799 (1.9); 7.0718 (2.2); 7.0511 (5.0); 7.0477 (5.1); 7.0383 (6.7); 7.0281 (3.3); 7.0099 (0.4); 6.9980 (0.5); 4.8708 (3.2); 4.8318 (3.5); 4.2556 (5.6); 4.2388 (16.0); 4.2218 (6.2); 4.2007 (3.9); 3.8722 (0.6); 3.8621 (1.2); 3.8512 (1.9); 3.8409 (2.3); 3.8306 (2.0); 3.8198 (1.4); 3.8096 (0.7); 3.1305 (6.0); 3.1136 (12.0); 3.0967 (5.8); 2.6841 (2.6); 2.6742 (2.7); 2.6453 (3.3); 2.6353 (3.4); 2.5356 (0.7); 2.5178 (0.9); 2.5119 (0.9); 2.4930 (2.2); 2.4744 (1.9); 2.4692 (2.0); 2.4509 (1.8); 2.4237 (1.7); 2.4092 (1.9); 2.3992 (2.4); 2.3848 (2.6); 2.3779 (4.0); 2.3667 (1.0); 2.3558 (4.4); 2.3390 (3.1); 2.3168 (2.6); 2.2951 (1.0); 2.2760 (1.5); 2.2716 (1.0); 2.2628 (1.2); 2.2577 (1.1); 2.2517 (1.2); 2.2433 (1.7); 2.2387 (1.2); 2.2333 (0.8); 2.2246 (1.0); 2.2189 (1.3); 2.2002 (0.6); 1.8500 (0.8); 1.8371 (1.3); 1.8255 (1.5); 1.8155 (1.5); 1.8043 (1.4); 1.7931 (1.4); 1.7810 (1.0); 1.7679 (0.7); 1.5958 (37.9); 1.2550 (0.5) I.1-024:1H NMR (400.0MHz, d6-DMSO): δ= 7.3813 (0.9); 7.3773 (1.0); 7.3609 (1.9); 7.3568 (2.1); 7.3507 (1.1); 7.3411 (1.3); 7.3351 (2.1); 7.3307 (1.8); 7.3147 (1.1); 7.3106 (1.1); 7.2095 (1.2); 7.2055 (1.3); 7.1968 (1.2); 7.1929 (1.4); 7.1896 (2.2); 7.1858 (2.4); 7.1769 (2.2); 7.1733 (2.4); 7.1693 (1.5); 7.1653 (1.5); 7.1565 (1.3); 7.1529 (1.4); 7.0992 (2.2); 7.0834 (2.9); 7.0798 (2.7); 7.0639 (1.5); 4.7341 (3.2); 4.6941 (3.9); 4.6676 (15.7); 4.6668 (15.5); 4.6615 (15.9); 4.6606 (15.6); 4.2611 (4.4); 4.2213 (3.8); 4.0208 (1.0); 4.0031 (1.0); 3.8310 (0.9); 3.8206 (1.6); 3.8102 (2.4); 3.8001 (2.7); 3.7900 (2.4); 3.7797 (1.9); 3.7694 (1.0); 3.6357 (7.1); 3.5480 (7.2); 3.5418 (16.0); 3.5357 (6.8); 3.1674 (2.2); 2.8446 (3.4); 2.8344 (3.4); 2.8044 (4.6); 2.7942 (4.3); 2.6744 (0.7); 2.6698 (1.0); 2.6651 (0.8); 2.5908 (4.9); 2.5695 (4.8); 2.5507 (4.1); 2.5458 (0.6); 2.5400 (0.8); 2.5293 (4.0); 2.5233 (2.6); 2.5186 (3.5); 2.5099 (49.2); 2.5053 (105.4); 2.5007 (146.4); 2.4960 (102.8); 2.4915 (46.3); 2.4757 (0.6); 2.4646 (1.1); 2.4477 (1.1); 2.4385 (0.7); 2.4236 (2.5); 2.4059 (2.2); 2.4007 (2.0); 2.3922 (0.8); 2.3846 (1.0); 2.3692 (0.6); 2.3322 (0.8); 2.3275 (1.0); 2.3228 (0.7); 2.2919 (1.7); 2.2796 (1.8); 2.2673 (3.1); 2.2551 (3.1); 2.2259 (4.6); 2.2167 (2.7); 2.2137 (2.3); 2.2040 (1.8); 2.1980 (1.4); 2.1929 (0.8); 2.1859 (2.2); 2.1794 (1.1); 2.1734 (0.8); 2.1665 (1.4); 2.1606 (1.3); 2.1419 (0.8); 2.0720 (1.0); 1.7875 (0.5); 1.7619 (2.0); 1.7506 (1.6); 1.7399 (2.3); 1.7326 (1.2); 1.7276 (1.2); 1.7229 (1.2); 1.7186 (1.3); 1.7081 (1.3); 1.6960 (0.9); 1.1543 (1.3); 1.1365 (2.6); 1.1187 (1.2); 0.0080 (0.6); - 0.0002 (22.9); -0.0085 (0.6) I.1-025:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.3828 (2.8); 7.3788 (3.0); 7.3623 (5.7); 7.3582 (6.3); 7.3522 (3.3); 7.3425 (4.0); 7.3363 (6.2); 7.3321 (5.4); 7.3160 (3.4); 7.3121 (3.3); 7.2091 (3.6); 7.2051 (3.8); 7.1964 (3.8); 7.1924 (4.4); 7.1892 (6.6); 7.1854 (7.0); 7.1765 (6.5); 7.1729 (7.2); 7.1689 (4.4); 7.1649 (4.2); 7.1561 (3.7); 7.1524 (4.0); 7.0886 (6.8); 7.0727 (9.1); 7.0692 (8.3); 7.0531 (4.7); 4.8884 (2.2); 4.8863 (2.3); 4.8687 (8.7); 4.8510 (12.0); 4.8490 (12.2); 4.8313 (8.8); 4.8137 (2.3); 4.8114 (2.2); 4.7146 (10.2); 4.6748 (12.1); 4.2630 (13.4); 4.2231 (11.4); 3.8305 (0.9); 3.8233 (2.4); 3.8124 (5.2); 3.8029 (6.4); 3.7924 (8.6); 3.7825 (5.8); 3.7724 (4.7); 3.7616 (1.9); 3.3641 (1.6); 3.3429 (0.8); 3.3388 (1.2); 3.3339 (2.4); 3.3147 (672.4); 3.2910 (17.4); 3.2631 (0.7); 3.1761 (0.6); 3.1629 (0.6); 2.7359 (10.9); 2.7251 (11.0); 2.6960 (15.2); 2.6852 (14.5); 2.6749 (1.3); 2.6703 (1.5); 2.6657 (1.0); 2.5459 (0.8); 2.5405 (1.1); 2.5238 (3.8); 2.5191 (5.7); 2.5105 (82.5); 2.5058 (163.7); 2.5012 (225.8); 2.4966 (159.3); 2.4919 (85.2); 2.4797 (1.4); 2.4720 (11.9); 2.4516 (11.4); 2.4408 (3.1); 2.4316 (0.9); 2.4234 (3.5); 2.4141 (2.2); 2.3997 (7.8); 2.3821 (6.1); 2.3762 (5.5); 2.3650 (2.5); 2.3600 (2.9); 2.3435 (1.2); 2.3374 (0.6); 2.3326 (1.2); 2.3280 (1.8); 2.3234 (1.1); 2.3188 (0.5); 2.2958 (5.5); 2.2827 (6.1); 2.2712 (9.9); 2.2630 (5.6); 2.2582 (11.2); 2.2486 (4.3); 2.2450 (5.7); 2.2428 (7.6); 2.2385 (9.3); 2.2365 (9.1); 2.2323 (11.8); 2.2301 (13.6); 2.2255 (15.7); 2.2185 (15.1); 2.2145 (13.2); 2.2125 (16.0); 2.2081 (9.3); 2.2059 (8.0); 2.2024 (9.7); 2.1947 (8.7); 2.1880 (8.2); 2.1847 (6.8); 2.1781 (3.3); 2.1721 (2.3); 2.1651 (4.1); 2.1588 (3.5); 2.1405 (2.1); 2.0724 (0.7); 1.9896 (0.6); 1.9858 (2.2); 1.9800 (1.4); 1.9770 (2.7); 1.9700 (2.1); 1.9663 (3.1); 1.9608 (6.7); 1.9572 (4.7); 1.9551 (5.1); 1.9522 (7.9); 1.9452 (5.4); 1.9413 (6.6); 1.9359 (8.2); 1.9327 (9.2); 1.9302 (8.0); 1.9272 (8.3); 1.9214 (5.6); 1.9171 (5.3); 1.9106 (7.0); 1.9079 (6.8); 1.9058 (5.4); 1.9022 (5.4); 1.8967 (3.1); 1.8931 (2.2); 1.8859 (3.3); 1.8806 (1.1); 1.8773 (2.3); 1.8733 (0.6); 1.7838 (1.0); 1.7620 (2.9); 1.7562 (7.6); 1.7515 (3.9); 1.7492 (3.8); 1.7450 (7.9); 1.7374 (4.3); 1.7315 (9.9); 1.7269 (8.7); 1.7246 (9.8); 1.7219 (7.6); 1.7178 (5.8); 1.7155 (6.7); 1.7092 (2.9); 1.7067 (5.1); 1.7023 (7.0); 1.7000 (10.3); 1.6976 (7.2); 1.6932 (4.5); 1.6905 (4.8); 1.6821 (1.6); 1.6797 (1.6); 1.6753 (2.5); 1.6729 (2.5); 1.6685 (1.3); 1.6661 (1.2); 1.6268 (3.0); 1.6068 (5.3); 1.6018 (5.8); 1.5866 (3.4); 1.5816 (11.1); 1.5766 (4.0); 1.5749 (5.1); 1.5615 (5.5); 1.5597 (3.6); 1.5564 (6.0); 1.5547 (8.5); 1.5497 (2.4); 1.5362 (2.9); 1.5345 (3.9); 1.5295 (3.2); 1.5093 (1.5); 0.0079 (0.6); -0.0002 (19.9); -0.0085 (0.5) I.1-026:1H NMR (400.0MHz, d6-DMSO): δ= 7.3625 (1.0); 7.3584 (1.1); 7.3524 (0.6); 7.3427 (0.7); 7.3365 (1.0); 7.3324 (0.9); 7.3162 (0.6); 7.3123 (0.6); 7.2101 (0.6); 7.2061 (0.6); 7.1974 (0.6); 7.1934 (0.7); 7.1901 (1.1); 7.1863 (1.2); 7.1775 (1.1); 7.1738 (1.2); 7.1698 (0.8); 7.1658 (0.7); 7.1570 (0.6); 7.1533 (0.7); 7.0898 (1.1); 7.0739 (1.6); 7.0704 (1.4); 7.0544 (0.8); 4.8813 (0.9); 4.8657 (2.5); 4.8500 (3.5); 4.8344 (2.6); 4.8187 (1.0); 4.7207 (1.7); 4.6810 (2.0); 4.2640 (2.3); 4.2241 (1.9); 3.8189 (0.8); 3.8094 (1.1); 3.7989 (1.5); 3.7888 (1.0); 3.7789 (0.8); 3.4236 (20.1); 3.1686 (1.0); 2.7196 (2.0); 2.7088 (2.0); 2.6801 (2.8); 2.6749 (0.5); 2.6694 (2.8); 2.5237 (0.7); 2.5190 (1.1); 2.5104 (19.1); 2.5058 (41.5); 2.5012 (57.3); 2.4965 (40.0); 2.4919 (18.4); 2.4689 (2.9); 2.4498 (2.1); 2.4294 (2.1); 2.4242 (0.7); 2.4000 (1.4); 2.3821 (1.0); 2.3762 (0.9); 2.3599 (0.5); 2.2992 (1.0); 2.2859 (1.1); 2.2746 (1.7); 2.2615 (1.6); 2.2332 (1.2); 2.2292 (1.3); 2.2270 (1.3); 2.2216 (0.9); 2.2179 (0.8); 2.2145 (1.0); 2.2042 (0.9); 2.1984 (0.7); 2.1866 (1.0); 2.1797 (0.6); 2.1669 (0.7); 2.1603 (0.6); 1.7586 (1.1); 1.7473 (1.1); 1.7400 (0.6); 1.7339 (1.0); 1.7292 (0.6); 1.7233 (0.6); 1.7173 (0.8); 1.7047 (0.6); 1.1496 (16.0); 1.1465 (15.9); 1.1340 (15.8); 1.1309 (15.9); -0.0002 (1.0) I.1-027:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.3813 (1.0); 7.3609 (2.1); 7.3383 (2.1); 7.3352 (2.0); 7.3147 (1.1); 7.2100 (1.1); 7.2064 (1.2); 7.1973 (1.2); 7.1898 (2.2); 7.1866 (2.3); 7.1770 (2.1); 7.1740 (2.4); 7.1661 (1.3); 7.1570 (1.1); 7.1536 (1.3); 7.0890 (2.3); 7.0730 (3.1); 7.0537 (1.5); 5.7926 (0.9); 5.7759 (1.9); 5.7670 (0.9); 5.7592 (0.9); 5.7501 (2.8); 5.7330 (2.8); 5.7239 (1.0); 5.7161 (1.0); 5.7072 (2.2); 5.6904 (1.0); 5.1063 (1.3); 5.1023 (3.2); 5.0974 (3.7); 5.0935 (1.5); 5.0632 (1.2); 5.0593 (2.9); 5.0543 (3.6); 5.0500 (4.2); 5.0470 (2.2); 5.0448 (2.8); 5.0418 (1.3); 5.0273 (1.4); 5.0242 (3.1); 5.0213 (2.0); 5.0192 (2.6); 5.0161 (1.1); 4.8686 (1.1); 4.8508 (1.5); 4.8488 (1.5); 4.8311 (1.1); 4.7250 (2.4); 4.7144 (1.3); 4.6854 (2.8); 4.6742 (1.6); 4.2566 (3.5); 4.2167 (3.0); 4.0464 (5.8); 4.0299 (13.0); 4.0134 (6.4); 3.8183 (0.8); 3.8119 (1.0); 3.8074 (1.4); 3.7976 (2.0); 3.7919 (1.8); 3.7874 (2.5); 3.7818 (1.5); 3.7774 (1.9); 3.7721 (1.3); 3.7673 (1.5); 3.7609 (0.8); 3.7568 (0.8); 3.5904 (16.0); 3.1680 (2.5); 2.7609 (2.4); 2.7502 (2.5); 2.7355 (1.3); 2.7245 (1.7); 2.7211 (3.5); 2.7105 (3.3); 2.6956 (2.0); 2.6848 (1.8); 2.6746 (0.7); 2.6700 (1.0); 2.6653 (0.8); 2.6000 (0.5); 2.5234 (2.1); 2.5206 (4.7); 2.5102 (54.9); 2.5056 (118.5); 2.5009 (165.6); 2.4963 (114.3); 2.4917 (53.2); 2.4810 (3.6); 2.4718 (1.4); 2.4601 (2.8); 2.4549 (1.3); 2.4507 (3.1); 2.4455 (2.5); 2.4415 (2.1); 2.4249 (1.4); 2.4164 (1.1); 2.4074 (0.8); 2.4011 (2.6); 2.3834 (2.0); 2.3790 (1.9); 2.3612 (1.2); 2.3324 (0.8); 2.3277 (1.0); 2.3230 (0.8); 2.3140 (1.2); 2.3105 (1.9); 2.3071 (1.2); 2.2974 (3.8); 2.2939 (7.0); 2.2906 (4.0); 2.2807 (4.9); 2.2774 (6.1); 2.2739 (3.8); 2.2686 (3.0); 2.2640 (1.8); 2.2606 (2.6); 2.2561 (3.7); 2.2428 (1.1); 2.2385 (1.3); 2.2365 (1.2); 2.2322 (1.5); 2.2267 (3.2); 2.2189 (3.7); 2.2152 (2.7); 2.2124 (2.4); 2.2076 (2.1); 2.1941 (2.1); 2.1878 (2.0); 2.1830 (1.4); 2.1758 (1.7); 2.1691 (1.0); 2.1642 (1.0); 2.1562 (1.2); 2.1499 (1.0); 2.1316 (0.6); 2.0721 (1.2); 1.9607 (0.8); 1.9549 (0.6); 1.9521 (1.0); 1.9451 (0.7); 1.9412 (0.8); 1.9358 (1.0); 1.9325 (1.1); 1.9301 (1.0); 1.9271 (1.0); 1.9213 (0.7); 1.9170 (0.7); 1.9104 (0.9); 1.9077 (0.8); 1.9021 (0.7); 1.7623 (1.0); 1.7553 (2.1); 1.7492 (0.7); 1.7437 (2.2); 1.7315 (2.4); 1.7270 (2.0); 1.7248 (2.1); 1.7200 (1.5); 1.7131 (1.7); 1.7067 (0.8); 1.7001 (2.2); 1.6932 (0.7); 1.6882 (0.9); 1.6067 (0.7); 1.6017 (0.7); 1.5815 (1.4); 1.5748 (0.6); 1.5614 (0.7); 1.5546 (1.1); 1.5345 (0.5); 0.0080 (0.6); 0.0023 (0.7); -0.0002 (20.5); -0.0085 (0.6) I.1-028:1H NMR (400.1 MHz, CDCl3): δ= 7.5188 (1.2); 7.3157 (1.4); 7.3097 (10.2); 7.3076 (4.4); 7.3043 (3.9); 7.2974 (2.1); 7.2913 (14.0); 7.2879 (13.8); 7.2820 (2.6); 7.2781 (1.3); 7.2745 (5.0); 7.2715 (6.0); 7.2694 (14.2); 7.2668 (3.9); 7.2659 (4.2); 7.2600 (208.0); 7.2535 (3.8); 7.2526 (3.2); 7.2510 (2.2); 7.2501 (1.9); 7.2493 (1.7); 7.2485 (1.5); 7.2476 (1.3); 7.2468 (1.3); 7.2461 (1.1); 7.2452 (1.0); 7.2444 (0.9); 7.2436 (0.9); 7.2428 (0.8); 7.2420 (0.7); 7.2411 (0.7); 7.2403 (0.7); 7.2395 (0.6); 7.2387 (0.5); 7.2379 (0.4); 7.2370 (0.4); 7.2362 (0.4); 7.2354 (0.4); 7.2338 (0.3); 7.1133 (1.1); 7.1030 (1.4); 7.0982 (1.9); 7.0957 (1.3); 7.0882 (3.6); 7.0783 (2.6); 7.0703 (4.1); 7.0641 (4.0); 7.0590 (4.0); 7.0472 (15.9); 7.0374 (15.1); 7.0324 (4.4); 7.0289 (5.9); 7.0220 (4.1); 7.0132 (0.6); 7.0025 (0.8); 6.9951 (3.3); 6.9925 (5.8); 6.9898 (3.5); 6.9762 (4.2); 6.9741 (9.8); 6.9720 (4.8); 6.9583 (2.5); 6.9556 (4.6); 6.9530 (2.7); 6.9098 (2.0); 6.9079 (2.4); 6.9044 (12.8); 6.9017 (16.0); 6.8997 (8.1); 6.8964 (4.4); 6.8874 (4.3); 6.8850 (7.2); 6.8824 (13.8); 6.8799 (11.8); 6.8735 (1.5); 4.8834 (4.9); 4.8796 (5.0); 4.8446 (5.6); 4.8407 (5.7); 4.4396 (9.1); 4.4333 (4.3); 4.4286 (10.7); 4.4247 (8.2); 4.4219 (4.6); 4.4161 (13.5); 4.2610 (8.0); 4.2221 (7.2); 4.1668 (14.2); 4.1617 (4.4); 4.1577 (8.4); 4.1548 (13.8); 4.1490 (4.2); 4.1434 (11.6); 3.9179 (1.2); 3.9070 (2.3); 3.8965 (3.4); 3.8861 (3.9); 3.8759 (3.4); 3.8655 (2.5); 3.8548 (1.3); 3.6679 (9.8); 3.4895 (0.4); 2.7731 (5.7); 2.7630 (5.8); 2.7342 (7.5); 2.7241 (7.3); 2.6981 (0.7); 2.6876 (0.7); 2.5477 (1.2); 2.5460 (1.2); 2.5299 (1.6); 2.5281 (1.6); 2.5234 (1.5); 2.5215 (1.5); 2.5048 (3.7); 2.4853 (3.6); 2.4802 (10.6); 2.4583 (8.3); 2.4412 (6.4); 2.4225 (4.3); 2.4194 (6.8); 2.4144 (1.9); 2.4082 (4.0); 2.3980 (5.6); 2.3837 (5.1); 2.3799 (2.2); 2.3759 (1.0); 2.3712 (0.5); 2.3656 (1.5); 2.3551 (2.8); 2.3412 (2.8); 2.3045 (2.2); 2.2850 (2.7); 2.2801 (1.7); 2.2723 (2.6); 2.2671 (2.2); 2.2605 (2.1); 2.2542 (3.0); 2.2526 (2.8); 2.2477 (2.1); 2.2427 (1.5); 2.2344 (2.1); 2.2279 (2.1); 2.2099 (1.4); 2.1326 (1.7); 2.0912 (2.6); 2.0041 (1.3); 1.8820 (1.8); 1.8707 (2.0); 1.8684 (2.3); 1.8575 (2.9); 1.8496 (2.3); 1.8469 (2.4); 1.8440 (2.2); 1.8380 (2.2); 1.8359 (2.4); 1.8326 (2.1); 1.8246 (2.5); 1.8140 (1.7); 1.8113 (1.6); 1.7997 (1.4); 1.5592 (12.2); 1.4369 (0.9); 1.4227 (0.9); 1.2845 (0.6); 1.2554 (2.0); 0.8800 (0.4); 0.8456 (0.4); 0.8358 (0.5); 0.0081 (1.1); 0.0061 (0.6); 0.0000 (36.6) I.1-029:1H NMR (400.0MHz, d6-DMSO): δ= 7.3630 (0.9); 7.3589 (1.0); 7.3528 (0.5); 7.3432 (0.6); 7.3370 (1.0); 7.3328 (0.9); 7.3168 (0.5); 7.3127 (0.5); 7.2091 (0.6); 7.2051 (0.6); 7.1964 (0.6); 7.1924 (0.7); 7.1892 (1.1); 7.1854 (1.1); 7.1765 (1.0); 7.1729 (1.2); 7.1688 (0.7); 7.1648 (0.7); 7.1561 (0.6); 7.1524 (0.6); 7.0919 (1.0); 7.0756 (1.4); 7.0566 (0.7); 4.8077 (0.5); 4.8010 (0.7); 4.7920 (0.8); 4.7897 (0.7); 4.7870 (0.7); 4.7846 (0.8); 4.7780 (0.7); 4.7757 (0.7); 4.7690 (0.5); 4.7311 (1.6); 4.6913 (1.9); 4.2601 (1.6); 4.2202 (1.3); 3.8119 (0.7); 3.8021 (1.0); 3.7918 (1.3); 3.7818 (1.0); 3.7717 (0.7); 3.4307 (10.7); 3.1680 (0.7); 2.7543 (1.0); 2.7474 (1.0); 2.7437 (1.1); 2.7369 (1.0); 2.7149 (1.3); 2.7080 (1.4); 2.7043 (1.3); 2.6976 (1.2); 2.5500 (0.6); 2.5454 (0.6); 2.5403 (0.6); 2.5236 (0.9); 2.5188 (1.2); 2.5102 (17.0); 2.5056 (36.3); 2.5010 (50.3); 2.4963 (35.4); 2.4918 (16.7); 2.4781 (1.4); 2.4717 (1.2); 2.4594 (0.8); 2.4533 (0.6); 2.4388 (1.3); 2.4322 (1.2); 2.4222 (0.5); 2.4061 (0.7); 2.3989 (0.6); 2.3815 (0.9); 2.3010 (0.6); 2.2881 (0.7); 2.2775 (1.0); 2.2761 (1.0); 2.2632 (1.2); 2.2347 (0.7); 2.2280 (1.4); 2.2153 (0.6); 2.2124 (0.8); 2.2018 (0.8); 2.1961 (0.6); 2.1838 (0.8); 2.1644 (0.6); 2.1581 (0.5); 1.7478 (0.7); 1.7456 (0.6); 1.7339 (0.8); 1.7233 (0.6); 1.7176 (0.8); 1.7034 (0.7); 1.4766 (0.6); 1.4665 (0.5); 1.4625 (0.8); 1.4575 (0.9); 1.4531 (0.8); 1.4480 (0.8); 1.4433 (1.1); 1.4389 (1.0); 1.4347 (0.9); 1.4307 (0.8); 1.4246 (1.1); 1.4203 (1.0); 1.4169 (0.6); 1.4118 (0.9); 1.4089 (0.9); 1.4049 (0.7); 1.3954 (0.7); 1.3912 (0.8); 1.2861 (0.6); 1.2757 (0.6); 1.2723 (0.7); 1.2675 (0.7); 1.2639 (0.9); 1.2574 (0.9); 1.2537 (0.9); 1.2489 (0.9); 1.2456 (0.9); 1.2395 (1.1); 1.2351 (0.8); 1.2309 (1.0); 1.2218 (1.0); 1.2133 (0.7); 1.2056 (0.5); 1.1247 (8.4); 1.1178 (8.5); 1.1091 (8.4); 1.1021 (8.4); 0.8641 (7.1); 0.8458 (16.0); 0.8275 (5.8); -0.0002 (12.0) I.1-031:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.3833 (0.6); 7.3793 (0.6); 7.3629 (1.2); 7.3588 (1.4); 7.3527 (0.7); 7.3431 (0.9); 7.3370 (1.3); 7.3327 (1.2); 7.3166 (0.7); 7.3126 (0.7); 7.2098 (0.8); 7.2059 (0.8); 7.1972 (0.8); 7.1932 (0.9); 7.1899 (1.4); 7.1862 (1.5); 7.1773 (1.4); 7.1736 (1.5); 7.1696 (0.9); 7.1656 (0.9); 7.1569 (0.8); 7.1532 (0.9); 7.0943 (1.3); 7.0781 (1.8); 7.0598 (0.9); 4.7399 (1.6); 4.7332 (2.7); 4.7247 (2.0); 4.7173 (1.9); 4.7090 (1.9); 4.7014 (2.3); 4.6935 (3.0); 4.6861 (1.1); 4.2622 (2.8); 4.2224 (2.4); 3.8145 (0.9); 3.8046 (1.4); 3.7943 (1.7); 3.7843 (1.3); 3.7741 (1.0); 3.4668 (16.0); 3.1680 (1.2); 2.7597 (1.3); 2.7546 (1.4); 2.7492 (1.4); 2.7442 (1.3); 2.7203 (1.8); 2.7154 (1.8); 2.7098 (1.8); 2.7049 (1.7); 2.5235 (1.2); 2.5188 (1.7); 2.5102 (28.0); 2.5056 (61.7); 2.5010 (84.6); 2.4963 (57.8); 2.4917 (26.1); 2.4843 (2.6); 2.4798 (2.1); 2.4657 (1.5); 2.4613 (1.4); 2.4449 (1.5); 2.4404 (1.7); 2.4231 (0.6); 2.4066 (0.9); 2.3999 (0.9); 2.3890 (0.7); 2.3825 (1.2); 2.3766 (0.7); 2.3656 (0.6); 2.3278 (0.6); 2.3000 (0.8); 2.2868 (0.9); 2.2775 (1.3); 2.2753 (1.3); 2.2623 (1.5); 2.2338 (1.0); 2.2292 (1.7); 2.2177 (1.0); 2.2144 (1.1); 2.2039 (1.1); 2.1982 (0.8); 2.1865 (1.2); 2.1794 (0.7); 2.1667 (0.8); 2.1601 (0.7); 2.0722 (0.5); 1.7639 (0.7); 1.7531 (1.2); 1.7420 (1.2); 1.7348 (0.8); 1.7288 (0.9); 1.7232 (0.8); 1.7112 (0.8); 1.6975 (0.6); 1.5145 (1.1); 1.4958 (4.0); 1.4799 (4.5); 1.4773 (4.7); 1.4614 (4.4); 1.4429 (1.4); 1.1223 (12.5); 1.1159 (12.5); 1.1066 (12.4); 1.1002 (12.4); 0.8300 (5.2); 0.8261 (5.2); 0.8115 (11.2); 0.8076 (11.2); 0.7927 (4.8); 0.7889 (4.7); -0.0002 (15.5) I.1-032:1H NMR (400.1 MHz, CDCl3): δ= 7.2680 (0.4); 7.2603 (39.0); 7.0907 (0.4); 7.0728 (0.5); 7.0665 (0.5); 7.0597 (0.6); 7.0495 (1.9); 7.0401 (1.8); 7.0350 (0.6); 7.0316 (0.6); 7.0245 (0.4); 6.8313 (16.0); 4.8857 (0.6); 4.8816 (0.6); 4.8469 (0.7); 4.8429 (0.6); 4.4111 (1.0); 4.3996 (1.1); 4.3963 (0.8); 4.3876 (1.4); 4.2610 (1.0); 4.2222 (0.9); 4.1134 (1.5); 4.1081 (0.4); 4.1043 (0.9); 4.1015 (1.4); 4.0958 (0.4); 4.0900 (1.2); 3.8992 (0.4); 3.8890 (0.4); 3.8787 (0.4); 3.7686 (12.8); 3.6680 (2.6); 2.7755 (0.6); 2.7654 (0.6); 2.7366 (0.9); 2.7264 (0.9); 2.5062 (0.4); 2.4847 (1.1); 2.4629 (1.1); 2.4458 (0.7); 2.4240 (1.1); 2.4143 (0.4); 2.4098 (0.4); 2.3995 (0.7); 2.3852 (0.6); 2.3567 (0.4); 2.2548 (0.3); 1.8604 (0.4); 1.5522 (4.2) I.1-034:1H NMR (400.1 MHz, CDCl3): δ= 7.9307 (12.0); 7.9106 (13.3); 7.9065 (7.9); 7.7014 (2.1); 7.6982 (2.3); 7.6848 (4.4); 7.6802 (6.4); 7.6747 (1.8); 7.6642 (4.7); 7.6610 (4.7); 7.6578 (2.1); 7.6051 (9.0); 7.6002 (3.2); 7.5875 (11.4); 7.5846 (11.3); 7.5701 (4.4); 7.5664 (5.0); 7.5194 (1.0); 7.3621 (0.5); 7.3183 (0.7); 7.2675 (73.0); 7.2657 (73.4); 7.2606 (172.6); 7.2381 (0.6); 7.2185 (0.6); 7.1331 (1.1); 7.1262 (1.1); 7.1152 (3.0); 7.1090 (2.9); 7.0960 (4.3); 7.0900 (3.3); 7.0840 (3.7); 7.0784 (3.4); 7.0729 (3.1); 7.0658 (5.5); 7.0595 (7.1); 7.0479 (11.7); 7.0394 (9.2); 7.0351 (7.8); 7.0161 (1.3); 6.9966 (1.0); 4.8916 (1.1); 4.8402 (5.6); 4.8014 (6.3); 4.4350 (8.1); 4.4201 (16.0); 4.4050 (8.5); 4.2634 (1.3); 4.2238 (1.2); 4.1828 (6.4); 4.1441 (5.7); 3.8839 (0.9); 3.8741 (0.6); 3.8633 (0.4); 3.8159 (1.0); 3.8053 (1.9); 3.7944 (3.0); 3.7845 (3.4); 3.7739 (2.9); 3.7632 (2.0); 3.7530 (1.0); 3.6747 (5.3); 3.6682 (11.4); 3.4911 (0.6); 3.4383 (9.0); 3.4238 (15.1); 3.4084 (8.1); 2.7371 (0.8); 2.7271 (0.8); 2.6983 (1.0); 2.6883 (0.9); 2.5468 (3.9); 2.5370 (4.0); 2.5127 (4.2); 2.5074 (5.4); 2.4974 (6.1); 2.4704 (3.8); 2.4512 (4.1); 2.4462 (3.1); 2.4369 (1.8); 2.4278 (3.3); 2.4151 (4.2); 2.4002 (4.5); 2.3908 (3.6); 2.3764 (4.9); 2.3577 (1.4); 2.3480 (1.7); 2.3337 (1.6); 2.3168 (0.4); 2.2990 (0.6); 2.2761 (1.7); 2.2475 (6.5); 2.2384 (2.4); 2.2318 (4.7); 2.2255 (7.8); 2.2196 (2.3); 2.2078 (5.4); 2.2011 (2.2); 2.1861 (4.3); 2.1339 (1.2); 2.1014 (1.6); 2.0945 (3.8); 2.0048 (1.0); 1.8647 (0.5); 1.8514 (0.5); 1.8429 (0.6); 1.8325 (0.6); 1.8194 (0.4); 1.8083 (0.3); 1.7845 (1.3); 1.7731 (1.9); 1.7603 (2.4); 1.7517 (2.5); 1.7405 (2.4); 1.7280 (1.9); 1.7163 (1.6); 1.7021 (1.0); 1.6582 (0.3); 1.5562 (20.6); 1.4778 (0.4); 1.4380 (0.7); 1.4236 (0.9); 1.3335 (0.9); 1.3206 (0.6); 1.3094 (0.8); 1.2847 (1.6); 1.2607 (3.9); 1.1827 (0.4); 1.0873 (0.3); 1.0523 (0.4); 0.9215 (0.3); 0.8948 (0.7); 0.8820 (1.2); 0.8531 (2.0); 0.8367 (2.2); 0.0154 (0.4); 0.0069 (12.3); 0.0051 (12.5); 0.0000 (29.8) I.1-035:1H NMR (400.1 MHz, CDCl3): δ= 7.5192 (0.9); 7.2837 (0.4); 7.2828 (0.4); 7.2820 (0.4); 7.2812 (0.4); 7.2804 (0.5); 7.2797 (0.4); 7.2771 (0.7); 7.2763 (0.7); 7.2755 (0.8); 7.2747 (0.9); 7.2730 (1.2); 7.2722 (1.4); 7.2605 (167.0); 7.2517 (16.6); 7.2460 (5.3); 7.2402 (1.2); 7.2347 (5.7); 7.2290 (17.3); 7.2205 (1.7); 7.2102 (1.3); 7.1613 (0.3); 7.1173 (0.7); 7.1074 (0.7); 7.1024 (1.4); 7.0923 (2.2); 7.0825 (1.5); 7.0744 (2.7); 7.0681 (2.5); 7.0624 (2.1); 7.0594 (2.0); 7.0520 (9.4); 7.0507 (8.9); 7.0420 (9.5); 7.0369 (3.0); 7.0336 (3.7); 7.0265 (2.6); 7.0176 (0.4); 7.0071 (0.4); 6.9965 (0.9); 6.8412 (1.8); 6.8326 (16.0); 6.8269 (4.7); 6.8156 (4.9); 6.8099 (14.2); 6.8013 (1.3); 4.8846 (3.2); 4.8806 (3.0); 4.8458 (3.6); 4.8418 (3.4); 4.4266 (6.6); 4.4206 (3.1); 4.4151 (7.4); 4.4118 (5.0); 4.4085 (3.1); 4.4031 (8.3); 4.2569 (4.6); 4.2181 (4.2); 4.1316 (8.6); 4.1263 (3.1); 4.1227 (5.5); 4.1197 (8.2); 4.1138 (2.8); 4.1082 (7.0); 3.9164 (0.8); 3.9057 (1.5); 3.8954 (2.2); 3.8850 (2.7); 3.8747 (2.2); 3.8643 (1.6); 3.8538 (0.8); 3.6681 (7.0); 2.7712 (3.5); 2.7611 (3.5); 2.7323 (4.7); 2.7221 (4.5); 2.6982 (0.5); 2.6879 (0.5); 2.5475 (0.7); 2.5295 (1.0); 2.5276 (1.0); 2.5232 (0.9); 2.5211 (0.8); 2.5047 (2.4); 2.4927 (5.4); 2.4866 (2.3); 2.4804 (2.0); 2.4787 (2.0); 2.4712 (5.1); 2.4624 (2.0); 2.4537 (4.0); 2.4364 (1.1); 2.4322 (4.0); 2.4259 (2.4); 2.4116 (2.6); 2.4013 (3.3); 2.3871 (3.2); 2.3831 (1.3); 2.3759 (0.7); 2.3690 (1.0); 2.3584 (1.8); 2.3445 (1.7); 2.3043 (1.3); 2.2848 (1.8); 2.2798 (1.2); 2.2720 (1.7); 2.2667 (1.5); 2.2602 (1.4); 2.2539 (1.8); 2.2522 (1.8); 2.2474 (1.5); 2.2423 (1.0); 2.2340 (1.4); 2.2293 (1.2); 2.2276 (1.3); 2.2094 (0.8); 2.1335 (1.4); 2.0926 (1.2); 2.0047 (1.0); 1.8813 (1.1); 1.8701 (1.3); 1.8676 (1.4); 1.8569 (1.8); 1.8490 (1.4); 1.8462 (1.6); 1.8433 (1.5); 1.8375 (1.5); 1.8350 (1.5); 1.8319 (1.4); 1.8238 (1.6); 1.8134 (1.1); 1.8106 (1.0); 1.7990 (0.9); 1.5557 (14.2); 1.4376 (0.7); 1.4234 (0.7); 1.2846 (0.4); 1.2552 (1.1); 0.8362 (0.3); 0.8313 (0.3); 0.0082 (1.0) I.1-036:1H NMR (400.1 MHz, CDCl3): δ= 7.2694 (0.4); 7.2686 (0.4); 7.2600 (56.2); 7.1138 (0.4); 7.0988 (0.9); 7.0919 (3.4); 7.0903 (4.1); 7.0890 (3.6); 7.0757 (1.6); 7.0702 (5.4); 7.0687 (4.6); 7.0644 (2.0); 7.0590 (1.6); 7.0468 (5.0); 7.0369 (4.6); 7.0323 (1.5); 7.0286 (1.8); 7.0218 (1.3); 6.9961 (0.4); 6.8046 (0.6); 6.7972 (5.5); 6.7920 (1.9); 6.7809 (1.6); 6.7757 (4.9); 6.7684 (0.6); 4.8815 (1.4); 4.8778 (1.5); 4.8428 (1.6); 4.8390 (1.7); 4.4208 (2.8); 4.4145 (1.3); 4.4093 (3.2); 4.4061 (2.4); 4.4035 (1.5); 4.3974 (3.9); 4.2584 (2.3); 4.2196 (2.1); 4.1333 (3.9); 4.1280 (1.4); 4.1242 (2.4); 4.1213 (3.9); 4.1157 (1.4); 4.1098 (3.3); 3.9158 (0.4); 3.9050 (0.7); 3.8946 (1.0); 3.8841 (1.2); 3.8738 (1.1); 3.8633 (0.8); 3.8527 (0.4); 3.6678 (2.8); 2.7717 (1.6); 2.7616 (1.7); 2.7328 (2.1); 2.7227 (2.1); 2.5438 (0.4); 2.5262 (0.5); 2.5212 (0.4); 2.5191 (0.4); 2.5015 (1.1); 2.4828 (1.0); 2.4766 (3.1); 2.4593 (1.0); 2.4547 (2.3); 2.4377 (2.0); 2.4196 (1.2); 2.4158 (2.0); 2.4053 (1.2); 2.3951 (1.6); 2.3808 (1.5); 2.3769 (0.7); 2.3628 (0.5); 2.3523 (0.8); 2.3383 (0.9); 2.3013 (0.7); 2.2848 (16.0); 2.2690 (1.0); 2.2640 (0.8); 2.2574 (0.7); 2.2494 (0.9); 2.2444 (0.6); 2.2395 (0.5); 2.2312 (0.6); 2.2247 (0.6); 2.2066 (0.4); 2.1320 (0.4); 2.0040 (0.4); 1.8792 (0.5); 1.8678 (0.6); 1.8654 (0.7); 1.8546 (0.8); 1.8467 (0.6); 1.8440 (0.7); 1.8412 (0.7); 1.8354 (0.6); 1.8330 (0.7); 1.8297 (0.6); 1.8217 (0.7); 1.8112 (0.5); 1.8084 (0.5); 1.7969 (0.4); 1.5619 (6.3); 1.2553 (0.5) I.1-038:1H NMR (400.0MHz, d6-DMSO): δ= 7.3803 (0.5); 7.3639 (1.0); 7.3598 (1.1); 7.3537 (0.6); 7.3440 (0.7); 7.3380 (1.1); 7.3336 (1.0); 7.3176 (0.6); 7.3136 (0.6); 7.2100 (0.6); 7.2061 (0.7); 7.1973 (0.6); 7.1935 (0.8); 7.1902 (1.2); 7.1864 (1.3); 7.1775 (1.2); 7.1739 (1.3); 7.1698 (0.8); 7.1659 (0.8); 7.1571 (0.7); 7.1534 (0.8); 7.0994 (1.2); 7.0832 (1.6); 7.0639 (0.8); 4.7475 (1.3); 4.7079 (1.5); 4.6399 (1.2); 4.6290 (1.3); 4.6253 (1.5); 4.6144 (1.4); 4.6133 (1.4); 4.6096 (1.3); 4.5988 (1.2); 4.2576 (2.2); 4.2179 (1.9); 3.8070 (0.8); 3.7968 (1.2); 3.7868 (1.4); 3.7766 (1.1); 3.7664 (0.8); 3.4183 (25.7); 3.1677 (1.0); 2.7849 (1.0); 2.7745 (1.1); 2.7689 (1.1); 2.7587 (1.1); 2.7456 (1.4); 2.7352 (1.4); 2.7298 (1.4); 2.7197 (1.3); 2.6699 (0.6); 2.5233 (1.1); 2.5186 (1.7); 2.5100 (30.5); 2.5054 (66.0); 2.5007 (92.6); 2.4961 (65.3); 2.4915 (30.8); 2.4810 (2.2); 2.4741 (1.6); 2.4629 (1.4); 2.4530 (1.6); 2.4417 (1.4); 2.4248 (0.6); 2.4107 (0.8); 2.4001 (0.8); 2.3929 (0.6); 2.3841 (0.8); 2.3758 (0.6); 2.3275 (0.6); 2.3028 (0.6); 2.2999 (0.6); 2.2890 (0.7); 2.2866 (0.7); 2.2783 (1.0); 2.2751 (1.0); 2.2645 (1.1); 2.2620 (1.2); 2.2367 (0.7); 2.2337 (0.7); 2.2269 (1.7); 2.2135 (0.8); 2.2107 (0.9); 2.1999 (0.9); 2.1942 (0.7); 2.1859 (0.5); 2.1823 (1.0); 2.1754 (0.6); 2.1625 (0.7); 2.1562 (0.6); 1.7676 (0.5); 1.7565 (0.8); 1.7484 (0.8); 1.7373 (1.0); 1.7298 (0.6); 1.7254 (1.3); 1.7227 (1.5); 1.7123 (0.8); 1.7056 (2.1); 1.6912 (1.8); 1.6886 (1.4); 1.6741 (1.2); 1.0775 (10.2); 1.0693 (10.3); 1.0616 (10.3); 1.0533 (10.1); 0.8384 (8.8); 0.8341 (16.0); 0.8316 (10.6); 0.8214 (8.8); 0.8171 (15.3); 0.8146 (10.4); 0.0079 (0.6); 0.0021 (0.8); -0.0002 (21.6); -0.0027 (1.2); -0.0085 (0.7) I.1-039:1H NMR (400.0MHz, d6-DMSO): δ= 8.9822 (0.9); 8.9751 (2.5); 8.9723 (2.4); 8.5699 (1.0); 8.5500 (1.0); 7.3976 (2.7); 7.3588 (0.8); 7.3362 (0.8); 7.1830 (0.8); 7.1703 (0.9); 7.0676 (0.7); 7.0480 (1.1); 7.0319 (0.6); 4.7177 (1.0); 4.6788 (1.3); 4.6586 (0.6); 4.6454 (0.6); 4.6384 (0.6); 4.1850 (1.2); 4.1450 (1.0); 3.7248 (0.7); 3.7144 (0.8); 3.7040 (0.7); 3.6433 (16.0); 3.6323 (5.2); 3.4005 (43.8); 3.1683 (1.9); 3.1533 (0.7); 3.1285 (0.9); 3.1152 (0.9); 3.0044 (0.9); 2.9808 (0.9); 2.9666 (0.7); 2.9433 (0.6); 2.6701 (0.7); 2.6654 (0.5); 2.5634 (0.8); 2.5523 (0.8); 2.5278 (1.3); 2.5236 (1.7); 2.5187 (2.7); 2.5102 (38.1); 2.5056 (83.0); 2.5010 (116.5); 2.4964 (81.0); 2.4918 (36.4); 2.3371 (0.6); 2.3326 (0.7); 2.3278 (0.8); 2.3231 (0.6); 2.3166 (0.8); 2.2955 (1.0); 2.2733 (0.7); 2.2567 (0.8); 2.2417 (1.4); 2.2323 (1.0); 2.2193 (1.7); 2.2058 (1.0); 2.2009 (0.7); 2.1845 (0.8); 2.0105 (0.5); 1.9785 (0.5); -0.0002 (1.4) I.1-040:1H NMR (400.1 MHz, CDCl3): δ= 7.5939 (0.3); 7.5408 (0.4); 7.5191 (1.0); 7.3295 (0.7); 7.3245 (5.0); 7.3186 (2.4); 7.3138 (0.4); 7.3083 (3.6); 7.3021 (16.0); 7.2973 (3.2); 7.2914 (0.7); 7.2869 (3.2); 7.2816 (16.7); 7.2759 (3.9); 7.2727 (1.0); 7.2719 (1.0); 7.2711 (1.0); 7.2703 (0.9); 7.2694 (1.0); 7.2686 (1.1); 7.2654 (4.2); 7.2645 (4.0); 7.2604 (153.4); 7.2553 (3.7); 7.2545 (3.1); 7.2537 (2.3); 7.2528 (1.9); 7.2520 (1.7); 7.2512 (1.5); 7.2504 (1.3); 7.2495 (1.1); 7.2487 (1.0); 7.2479 (0.8); 7.2471 (0.8); 7.2463 (0.7); 7.2454 (0.6); 7.2446 (0.6); 7.2438 (0.5); 7.2430 (0.5); 7.2422 (0.4); 7.2414 (0.4); 7.2405 (0.4); 7.2397 (0.4); 7.2389 (0.3); 7.2381 (0.3); 7.1274 (0.5); 7.1146 (1.2); 7.1098 (0.6); 7.1025 (2.2); 7.0917 (1.1); 7.0845 (1.9); 7.0777 (2.3); 7.0738 (1.2); 7.0673 (1.2); 7.0588 (7.1); 7.0524 (3.9); 7.0471 (6.2); 7.0399 (2.4); 7.0347 (2.8); 7.0275 (0.5); 6.9964 (0.8); 4.8845 (2.5); 4.8805 (2.5); 4.8457 (2.8); 4.8417 (2.7); 4.2610 (0.4); 4.2428 (3.8); 4.2360 (6.6); 4.2190 (13.7); 4.2022 (8.9); 3.8803 (0.6); 3.8696 (1.1); 3.8591 (1.7); 3.8489 (1.9); 3.8383 (1.6); 3.8279 (1.2); 3.8174 (0.6); 3.6680 (4.6); 3.1049 (6.9); 3.0880 (14.1); 3.0710 (6.5); 2.7004 (2.8); 2.6903 (2.8); 2.6615 (3.6); 2.6513 (3.4); 2.5420 (0.6); 2.5239 (0.7); 2.5193 (0.7); 2.4997 (1.8); 2.4809 (1.5); 2.4765 (1.4); 2.4576 (1.5); 2.4367 (0.6); 2.4311 (1.8); 2.4241 (0.4); 2.4165 (2.2); 2.4065 (2.7); 2.4019 (4.1); 2.3922 (2.6); 2.3882 (1.1); 2.3802 (3.8); 2.3739 (1.0); 2.3631 (4.0); 2.3495 (1.4); 2.3412 (2.9); 2.3002 (1.1); 2.2809 (1.3); 2.2760 (0.8); 2.2678 (1.2); 2.2625 (1.0); 2.2564 (1.0); 2.2482 (1.4); 2.2432 (1.1); 2.2381 (0.7); 2.2298 (1.0); 2.2237 (1.1); 2.2052 (0.6); 2.0945 (2.9); 2.0048 (0.9); 1.8549 (0.9); 1.8435 (1.0); 1.8410 (1.2); 1.8301 (1.4); 1.8222 (1.0); 1.8197 (1.2); 1.8170 (1.1); 1.8109 (1.0); 1.8083 (1.1); 1.8054 (1.0); 1.7971 (1.2); 1.7870 (0.8); 1.7842 (0.7); 1.7725 (0.7); 1.5518 (8.7); 1.2555 (1.0); 0.0083 (0.8); 0.0059 (0.4); 0.0051 (0.4); 0.0043 (0.6); 0.0034 (0.8); 0.0025 (1.4) I.1-041:1H NMR (400.1 MHz, d6-DMSO): δ= 16.4145 (0.6); 16.2990 (0.6); 16.2499 (0.6); 13.9263 (0.6); 12.3927 (0.6); 12.3615 (0.9); 12.3469 (1.7); 12.3246 (9.3); 12.2694 (0.6); 8.0558 (0.6); 7.6338 (1.2); 7.4203 (6.3); 7.3990 (13.3); 7.3933 (7.1); 7.3779 (8.1); 7.3720 (13.5); 7.3508 (7.1); 7.3073 (5.7); 7.3022 (6.1); 7.2877 (6.1); 7.2824 (6.9); 7.2732 (6.5); 7.2589 (5.6); 7.2535 (5.9); 7.1008 (6.3); 7.0960 (6.2); 7.0915 (6.5); 7.0862 (6.5); 7.0800 (5.9); 4.6385 (0.6); 4.6242 (12.7); 4.5855 (14.4); 4.2602 (0.6); 4.2387 (0.8); 4.2237 (0.6); 4.1570 (16.0); 4.1184 (13.8); 3.7772 (8.5); 3.7675 (2.8); 3.7564 (4.8); 3.7457 (7.3); 3.7356 (7.4); 3.7256 (6.9); 3.7149 (5.5); 3.7041 (2.4); 3.6002 (0.6); 3.5093 (1.4); 3.4927 (1.0); 3.4465 (2.0); 3.4404 (2.0); 3.4278 (1.9); 3.4105 (2.2); 3.3184 (45.5); 3.1684 (1.6); 3.1444 (0.9); 3.1291 (0.7); 3.1143 (0.7); 3.0862 (7.0); 3.0544 (0.6); 3.0413 (0.6); 2.6916 (11.1); 2.6815 (11.6); 2.6745 (2.3); 2.6695 (2.5); 2.6647 (1.9); 2.6518 (14.1); 2.6417 (13.3); 2.6128 (0.6); 2.5984 (0.7); 2.5785 (0.7); 2.5577 (0.6); 2.5097 (120.2); 2.5051 (262.8); 2.5006 (368.2); 2.4960 (264.0); 2.4915 (123.8); 2.4397 (3.2); 2.4224 (4.0); 2.4159 (3.6); 2.3985 (9.0); 2.3805 (7.2); 2.3741 (6.4); 2.3577 (6.2); 2.3456 (14.0); 2.3323 (2.4); 2.3233 (15.1); 2.3055 (15.7); 2.2906 (7.3); 2.2833 (13.9); 2.2663 (9.6); 2.2499 (2.0); 2.2385 (5.7); 2.2258 (6.2); 2.2160 (4.3); 2.1980 (5.4); 2.1922 (2.6); 2.1861 (4.9); 2.1808 (4.0); 2.1731 (3.6); 2.1689 (5.8); 2.1621 (3.7); 2.1566 (2.4); 2.1491 (4.0); 2.1440 (3.9); 2.1246 (2.2); 2.0715 (1.5); 1.7418 (3.1); 1.7305 (5.2); 1.7191 (6.1); 1.7084 (5.0); 1.7004 (5.9); 1.6947 (3.8); 1.6878 (5.5); 1.6764 (4.0); 1.6623 (2.6); 1.3037 (0.6); 1.2668 (0.7); 1.2345 (3.6); 1.1852 (0.7); 1.1780 (0.7); 1.1595 (0.8); 1.1415 (0.6); 1.1247 (0.7); 0.8675 (0.9); 0.8546 (0.8); 0.8281 (0.7); 0.8099 (0.7); 0.0081 (3.1) I.1-042:1H NMR (400.1 MHz, CDCl3): δ= 8.0105 (0.4); 7.9829 (0.5); 7.9140 (0.4); 7.7961 (0.4); 7.6100 (0.4); 7.5591 (0.4); 7.5306 (0.5); 7.5191 (0.9); 7.4864 (0.6); 7.4556 (0.4); 7.4145 (0.9); 7.3816 (8.9); 7.3636 (12.6); 7.3494 (1.2); 7.3163 (6.0); 7.2981 (12.8); 7.2795 (7.3); 7.2602 (120.3); 7.2396 (1.4); 7.2365 (1.1); 7.2227 (1.9); 7.2103 (0.8); 7.2065 (0.7); 7.2036 (1.1); 7.2001 (0.6); 7.1777 (2.6); 7.1529 (0.4); 7.1455 (1.4); 7.1288 (1.3); 7.1087 (4.8); 7.0835 (3.8); 7.0627 (2.6); 7.0478 (3.3); 7.0266 (1.6); 6.9965 (0.6); 6.9481 (3.0); 6.6665 (0.3); 4.7604 (5.3); 4.7221 (5.7); 4.2513 (7.6); 4.2344 (14.9); 4.2176 (6.9); 4.1329 (0.4); 4.0809 (6.3); 4.0427 (5.4); 3.8732 (1.1); 3.8612 (2.0); 3.8514 (2.7); 3.8409 (3.7); 3.8307 (2.6); 3.8205 (1.8); 3.8093 (0.6); 3.4900 (0.4); 3.1239 (8.7); 3.1071 (16.0); 3.0905 (6.8); 3.0246 (0.4); 2.5803 (3.6); 2.5691 (3.4); 2.5412 (4.8); 2.5302 (5.3); 2.5105 (2.9); 2.4917 (2.7); 2.4684 (2.3); 2.4458 (2.2); 2.4314 (2.5); 2.4214 (3.1); 2.4069 (3.3); 2.3882 (0.8); 2.3785 (1.3); 2.3640 (1.4); 2.3304 (4.5); 2.3094 (4.4); 2.2913 (3.6); 2.2705 (4.4); 2.2627 (1.5); 2.2520 (1.6); 2.2432 (2.1); 2.2192 (1.5); 2.1988 (0.6); 2.0040 (0.5); 1.8394 (1.2); 1.8275 (1.9); 1.8147 (2.0); 1.8036 (2.1); 1.7917 (2.0); 1.7826 (1.7); 1.7707 (1.2); 1.7566 (0.7); 1.6507 (0.6); 1.5618 (20.4); 1.4781 (0.6); 1.4433 (0.4); 1.2579 (0.4); 0.0886 (0.3); 0.0000 (19.6) I.1-044:1H NMR (400.1 MHz, d6-DMSO): δ= 18.4071 (0.6); 14.1020 (0.4); 12.3265 (5.4); 10.2103 (0.4); 8.6838 (0.4); 8.6715 (0.5); 7.6579 (2.6); 7.4492 (0.7); 7.4449 (0.7); 7.4205 (5.8); 7.3994 (12.0); 7.3937 (6.4); 7.3782 (7.0); 7.3724 (11.9); 7.3512 (6.6); 7.3071 (5.4); 7.3023 (5.7); 7.2879 (5.6); 7.2789 (6.6); 7.2735 (5.7); 7.2586 (5.4); 7.2534 (5.3); 7.1306 (0.5); 7.1017 (6.0); 7.0913 (6.1); 7.0864 (6.5); 7.0814 (5.6); 5.0716 (0.5); 4.6239 (12.5); 4.5851 (14.8); 4.2367 (0.6); 4.2230 (0.8); 4.2075 (0.5); 4.1572 (16.0); 4.1179 (13.8); 4.0888 (0.5); 4.0408 (0.4); 3.9751 (0.5); 3.9466 (0.7); 3.9267 (0.5); 3.8852 (0.4); 3.8613 (0.5); 3.8302 (0.5); 3.8102 (0.5); 3.7760 (14.1); 3.7667 (3.1); 3.7567 (5.0); 3.7460 (7.3); 3.7355 (7.6); 3.7251 (6.9); 3.7151 (5.3); 3.7043 (2.7); 3.6830 (0.7); 3.6480 (0.7); 3.6187 (0.8); 3.5891 (0.9); 3.5436 (1.1); 3.5103 (2.8); 3.4910 (2.7); 3.4693 (2.4); 3.3132 (248.5); 3.1696 (3.7); 3.1241 (0.9); 3.0929 (11.2); 3.0592 (0.7); 3.0500 (0.6); 3.0368 (0.6); 3.0291 (0.6); 3.0023 (0.6); 2.9993 (0.6); 2.9374 (0.5); 2.9081 (0.6); 2.8777 (0.6); 2.8287 (0.5); 2.8087 (0.4); 2.6914 (10.5); 2.6812 (11.0); 2.6742 (4.4); 2.6694 (5.8); 2.6650 (4.5); 2.6516 (13.1); 2.6415 (12.4); 2.6234 (0.7); 2.6006 (1.2); 2.5679 (0.6); 2.5546 (3.7); 2.5498 (5.6); 2.5456 (4.7); 2.5227 (10.4); 2.5092 (317.6); 2.5048 (667.4); 2.5004 (914.8); 2.4960 (655.6); 2.4917 (310.5); 2.4571 (3.3); 2.4470 (1.0); 2.4399 (1.9); 2.4225 (3.5); 2.4149 (3.2); 2.3983 (8.4); 2.3810 (6.5); 2.3751 (6.0); 2.3578 (5.9); 2.3454 (12.8); 2.3231 (16.2); 2.3052 (14.9); 2.2904 (6.5); 2.2829 (12.6); 2.2659 (8.8); 2.2494 (1.8); 2.2386 (5.1); 2.2259 (5.8); 2.2166 (4.1); 2.1984 (5.0); 2.1862 (4.5); 2.1801 (3.7); 2.1681 (5.7); 2.1625 (3.6); 2.1568 (2.4); 2.1487 (3.5); 2.1423 (3.8); 2.1249 (2.0); 2.0714 (3.1); 1.7589 (0.5); 1.7421 (2.6); 1.7307 (5.0); 1.7186 (5.9); 1.7075 (5.0); 1.6999 (5.6); 1.6944 (3.7); 1.6874 (5.3); 1.6754 (3.7); 1.6630 (2.4); 1.5083 (0.5); 1.3602 (0.6); 1.3432 (0.5); 1.2361 (6.2); 1.1965 (0.8); 1.1755 (0.7); 1.1588 (0.7); 1.1415 (0.7); 1.0849 (0.5); 0.9120 (0.7); 0.8950 (0.5); 0.8681 (0.7); 0.8532 (1.1); 0.8360 (0.9); 0.8148 (0.6); 0.1469 (1.0); 0.0498 (1.2); 0.0081 (6.4); 0.0006 (191.7); 0.0000 (199.1) I.1-046:1H NMR (400.0 MHz, i.e6-DMSO): δ= 12.7567 (0.8); 8.3619 (3.9); 8.3516 (3.1); 8.3412 (3.9); 8.3310 (2.9); 7.3727 (1.3); 7.3473 (3.1); 7.3267 (3.3); 7.3062 (1.8); 7.2825 (3.5); 7.2643 (9.7); 7.2466 (14.1); 7.2294 (8.3); 7.2177 (14.3); 7.2114 (12.4); 7.2047 (9.5); 7.2001 (9.4); 7.1862 (8.9); 7.1690 (4.5); 7.0540 (2.1); 7.0381 (4.4); 7.0187 (3.5); 7.0020 (1.2); 4.6968 (3.4); 4.6775 (2.5); 4.6566 (3.8); 4.6384 (2.9); 4.4900 (1.5); 4.4786 (1.5); 4.4653 (2.2); 4.4546 (2.5); 4.4442 (2.5); 4.4331 (2.2); 4.4229 (1.5); 4.3971 (1.0); 4.1805 (4.0); 4.1404 (3.6); 4.1247 (2.8); 4.0835 (2.5); 3.9638 (2.9); 3.6687 (2.2); 3.6574 (2.8); 3.6472 (2.9); 3.6368 (2.6); 3.6242 (2.3); 3.6140 (1.9); 3.6026 (1.6); 3.4414 (69.2); 3.1663 (16.0); 3.0935 (2.3); 3.0824 (2.9); 3.0744 (1.9); 3.0592 (3.0); 3.0482 (3.4); 3.0402 (2.2); 2.8384 (3.1); 2.8128 (3.2); 2.8038 (2.9); 2.7783 (2.5); 2.6990 (1.6); 2.6790 (2.2); 2.6745 (4.8); 2.6699 (6.7); 2.6653 (4.8); 2.5568 (1.6); 2.5522 (1.6); 2.5471 (1.3); 2.5401 (3.9); 2.5363 (4.6); 2.5233 (18.8); 2.5186 (27.7); 2.5100 (388.7); 2.5054 (843.8); 2.5008 (1175.8); 2.4962 (827.4); 2.4916 (375.5); 2.4669 (3.8); 2.4568 (5.0); 2.4521 (3.3); 2.4468 (1.7); 2.3812 (1.3); 2.3369 (2.9); 2.3322 (5.5); 2.3276 (7.5); 2.3229 (5.4); 2.3181 (2.8); 2.2913 (2.0); 2.2695 (3.3); 2.2476 (4.0); 2.2270 (3.8); 2.1974 (2.3); 2.1880 (4.2); 2.1728 (5.5); 2.1654 (5.0); 2.1529 (4.8); 2.1377 (3.5); 2.1316 (3.5); 2.1158 (3.3); 2.0732 (1.8); 1.9407 (1.1); 1.9087 (1.3); 1.8851 (1.6); 1.8636 (1.8); 1.8513 (1.3); 1.8393 (1.6); 1.8316 (1.9); 1.8073 (1.7); 1.7879 (0.8); 1.6787 (1.0); 1.6661 (1.3); 1.6558 (1.3); 1.6449 (1.3); 1.4707 (1.2); 1.4600 (1.8); 1.4491 (1.6); 1.4377 (1.6); 1.4273 (1.6); 1.0281 (2.0); 0.1460 (1.2); 0.0080 (9.4); -0.0002 (340.8); -0.0086 (10.2); -0.1495 (1.0) I.1-047:1H NMR (400.1 MHz, CDCl3): δ= 7.3933 (0.3); 7.3855 (3.3); 7.3800 (1.1); 7.3688 (1.1); 7.3633 (3.7); 7.3555 (0.4); 7.2679 (0.3); 7.2670 (0.4); 7.2662 (0.6); 7.2653 (0.7); 7.2609 (28.8); 7.2514 (0.3); 7.0961 (0.6); 7.0857 (0.4); 7.0783 (0.6); 7.0712 (0.6); 7.0672 (0.5); 7.0599 (0.5); 7.0523 (2.3); 7.0459 (1.2); 7.0418 (2.1); 7.0339 (1.0); 7.0282 (0.8); 6.8670 (0.4); 6.8593 (3.4); 6.8538 (1.1); 6.8426 (1.0); 6.8372 (3.2); 6.8294 (0.4); 4.8816 (0.7); 4.8778 (0.8); 4.8429 (0.8); 4.8390 (0.8); 4.2401 (1.1); 4.1991 (2.5); 4.1820 (4.0); 4.1651 (2.0); 3.8721 (0.4); 3.8614 (1.0); 3.8513 (0.6); 3.8408 (0.5); 3.8303 (0.4); 3.7955 (16.0); 3.6680 (1.6); 3.0034 (2.0); 2.9865 (4.2); 2.9695 (1.9); 2.7015 (0.9); 2.6915 (0.9); 2.6627 (1.1); 2.6527 (1.0); 2.5003 (0.6); 2.4818 (0.5); 2.4773 (0.4); 2.4583 (0.5); 2.4281 (0.5); 2.4140 (0.7); 2.4036 (0.8); 2.3964 (1.3); 2.3893 (0.8); 2.3853 (0.4); 2.3744 (1.2); 2.3605 (0.5); 2.3576 (1.0); 2.3467 (0.4); 2.3356 (0.9); 2.3009 (0.3); 2.2817 (0.4); 2.2685 (0.4); 2.2633 (0.3); 2.2572 (0.3); 2.2491 (0.4); 2.2440 (0.3); 2.2245 (0.3); 2.0923 (1.1); 1.8509 (0.4); 1.8486 (0.4); 1.8377 (0.5); 1.8295 (0.4); 1.8272 (0.4); 1.8244 (0.3); 1.8184 (0.4); 1.8160 (0.4); 1.8047 (0.4); 1.5634 (1.2) I.1-048:1H NMR (400.1 MHz, CDCl3): δ= 7.5187 (0.4); 7.3014 (4.4); 7.2812 (5.5); 7.2755 (1.2); 7.2616 (58.1); 7.2599 (62.6); 7.2091 (0.8); 7.1221 (4.6); 7.1012 (3.6); 7.0874 (0.7); 7.0797 (1.1); 7.0721 (1.1); 7.0618 (0.7); 7.0518 (3.7); 7.0417 (3.7); 7.0332 (1.3); 7.0290 (1.3); 6.9961 (0.4); 4.8778 (1.6); 4.8392 (1.7); 4.2391 (2.4); 4.2249 (3.1); 4.2078 (6.4); 4.2007 (2.3); 4.1912 (3.2); 3.8783 (0.3); 3.8682 (0.7); 3.8574 (1.0); 3.8470 (1.2); 3.8366 (1.0); 3.8264 (0.7); 3.8157 (0.3); 3.0740 (3.2); 3.0570 (6.3); 3.0402 (3.0); 2.6982 (1.4); 2.6883 (1.4); 2.6594 (1.8); 2.6494 (1.7); 2.5387 (0.4); 2.5206 (0.5); 2.5144 (0.5); 2.4960 (1.2); 2.4776 (1.1); 2.4718 (0.9); 2.4537 (1.0); 2.4246 (1.2); 2.4106 (1.0); 2.4005 (1.2); 2.3869 (3.0); 2.3661 (2.0); 2.3580 (0.8); 2.3483 (1.6); 2.3439 (0.8); 2.3216 (16.0); 2.2966 (0.5); 2.2778 (0.7); 2.2710 (0.4); 2.2637 (0.6); 2.2589 (0.5); 2.2534 (0.6); 2.2451 (0.9); 2.2393 (0.5); 2.2346 (0.4); 2.2253 (0.5); 2.2207 (0.6); 2.2015 (0.3); 2.0046 (0.5); 1.8555 (0.4); 1.8434 (0.7); 1.8311 (0.8); 1.8218 (0.7); 1.8103 (0.7); 1.8081 (0.7); 1.7985 (0.7); 1.7868 (0.5); 1.5476 (23.8); 0.0018 (5.3) I.1-049:1H NMR (400.0MHz, CDCl3): δ= 7.3483 (0.5); 7.3441 (0.6); 7.3275 (0.9); 7.3107 (0.6); 7.3065 (0.6); 7.2649 (8.0); 7.1927 (1.0); 7.1766 (0.6); 7.1726 (0.5); 7.0784 (0.9); 7.0759 (0.9); 7.0586 (1.3); 7.0562 (1.4); 7.0391 (0.6); 7.0365 (0.6); 5.3007 (1.1); 4.8692 (0.9); 4.8324 (1.0); 4.2589 (1.3); 4.2200 (1.2); 3.9037 (0.6); 3.8933 (0.8); 3.8830 (0.6); 3.6676 (16.0); 2.7314 (0.9); 2.7210 (1.0); 2.6924 (1.2); 2.6821 (1.2); 2.5138 (0.7); 2.4948 (0.6); 2.4901 (0.5); 2.4717 (0.6); 2.4429 (1.9); 2.4281 (0.8); 2.4214 (1.4); 2.4182 (1.1); 2.4040 (1.9); 2.3825 (1.0); 2.3751 (0.5); 2.3613 (0.5); 2.3035 (0.5); 2.2714 (0.6); 1.8554 (0.5); 1.2611 (0.5); 1.2544 (1.0); - 0.0002 (4.9) I.1-050:1H NMR (400.1 MHz, d6-DMSO): δ= 8.1400 (0.8); 8.1190 (0.8); 8.0535 (1.4); 8.0319 (1.4); 7.3771 (0.6); 7.3733 (0.6); 7.3525 (1.3); 7.3310 (1.4); 7.3106 (0.6); 7.2016 (0.7); 7.1828 (1.3); 7.1700 (1.4); 7.1502 (0.7); 7.0904 (1.0); 7.0715 (1.6); 7.0562 (0.8); 4.7376 (1.8); 4.6973 (2.0); 4.3465 (1.3); 4.3350 (1.4); 4.3245 (1.3); 4.3131 (1.4); 4.2479 (2.1); 4.2079 (1.8); 4.1679 (0.8); 4.1530 (0.8); 4.1472 (0.8); 4.1323 (0.8); 3.8020 (0.4); 3.7918 (0.8); 3.7808 (1.2); 3.7701 (1.5); 3.7599 (1.2); 3.7496 (0.9); 3.7390 (0.5); 3.4708 (0.3); 3.3853 (16.0); 2.6741 (0.6); 2.6692 (0.8); 2.6647 (0.6); 2.6570 (1.1); 2.6460 (1.0); 2.6312 (0.6); 2.6224 (1.5); 2.6114 (1.2); 2.5966 (0.8); 2.5856 (0.8); 2.5397 (0.5); 2.5227 (1.2); 2.5094 (40.5); 2.5048 (89.4); 2.5002 (126.9); 2.4956 (92.5); 2.4910 (44.2); 2.4498 (0.4); 2.4187 (0.4); 2.3957 (0.8); 2.3768 (1.2); 2.3545 (1.4); 2.3357 (2.2); 2.3274 (1.2); 2.3227 (0.9); 2.3138 (1.7); 2.3016 (1.2); 2.2936 (0.9); 2.2880 (1.1); 2.2792 (1.6); 2.2762 (1.4); 2.2636 (1.4); 2.2511 (1.3); 2.2332 (0.6); 2.2213 (0.7); 2.2094 (0.7); 2.1245 (0.5); 2.1047 (1.0); 2.0928 (0.8); 2.0808 (1.0); 2.0716 (1.7); 2.0616 (0.5); 2.0490 (1.0); 2.0296 (0.4); 1.8788 (0.4); 1.8617 (0.7); 1.8494 (0.8); 1.8438 (1.1); 1.8318 (1.3); 1.8205 (0.9); 1.8113 (1.0); 1.8023 (0.9); 1.7986 (0.9); 1.7889 (0.9); 1.7774 (0.8); 1.7721 (0.6); 1.7661 (0.6); 1.7481 (0.5); 1.3824 (0.4); 1.3717 (0.3); 1.3636 (0.3); 1.2960 (0.4); 1.2781 (0.7); 1.2615 (1.0); 1.2441 (1.0); 1.2260 (0.8); 1.2077 (0.5); 1.1896 (0.4); 1.1729 (0.5); 1.1669 (0.4); 1.1535 (0.8); 1.1347 (1.2); 1.1170 (0.9); 1.1004 (0.7); 1.0826 (0.4); 0.8484 (13.8); 0.8314 (15.4); 0.8156 (4.2); 0.0082 (0.4) I.1-051:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1339 (4.0); 7.1115 (12.4); 7.0979 (8.4); 7.0901 (4.2); 7.0778 (1.9); 6.9528 (3.6); 6.9418 (3.6); 6.9356 (1.7); 6.9298 (2.7); 6.9188 (2.6); 4.6503 (2.0); 4.6119 (2.2); 4.3157 (1.3); 4.3053 (3.3); 4.2946 (3.4); 4.2844 (1.5); 4.1260 (3.2); 4.1147 (4.8); 4.1036 (2.4); 4.0517 (2.2); 4.0133 (1.9); 3.7274 (0.7); 3.7168 (1.1); 3.7059 (1.2); 3.6958 (1.0); 3.6853 (0.7); 3.3469 (2.4); 3.3223 (495.0); 3.2912 (0.8); 3.1675 (0.9); 2.7817 (1.4); 2.7713 (1.4); 2.7416 (1.8); 2.7315 (1.6); 2.6704 (1.0); 2.5403 (0.7); 2.5102 (64.0); 2.5058 (132.9); 2.5013 (180.1); 2.4968 (126.4); 2.4925 (58.1); 2.4797 (2.7); 2.4579 (2.0); 2.4400 (1.6); 2.4180 (1.8); 2.3913 (1.3); 2.3728 (1.0); 2.3496 (0.8); 2.3280 (1.1); 2.2634 (16.0); 2.2501 (1.4); 2.2363 (1.3); 2.2080 (0.7); 2.1952 (0.8); 2.1376 (0.7); 2.1251 (0.6); 2.1125 (0.6); 2.1062 (0.9); 2.0874 (0.6); 2.0730 (0.8); 1.7173 (0.6); 1.7051 (0.8); 1.6944 (0.7); 1.6846 (0.7); 1.6733 (0.7); 1.6603 (0.6); -0.0002 (5.3) I.1-052:1H NMR (400.0MHz, d6-DMSO): δ= 7.2642 (2.9); 7.2466 (4.4); 7.2114 (4.8); 3.3179 (1950.0); 3.2683 (4.4); 3.1666 (16.0); 2.6747 (5.7); 2.6699 (8.5); 2.6652 (5.5); 2.5402 (3.9); 2.5234 (18.8); 2.5186 (28.8); 2.5100 (477.4); 2.5054 (1050.3); 2.5008 (1468.1); 2.4962 (1027.3); 2.4916 (461.4); 2.4560 (4.0); 2.3323 (6.1); 2.3276 (8.3); 2.3228 (6.3); 2.1528 (2.0); 2.0729 (2.6); -0.0002 (69.2) I.1-053:1H NMR (400.0MHz, d6-DMSO): δ= 7.8999 (0.8); 7.8930 (6.8); 7.8879 (1.9); 7.8758 (2.0); 7.8706 (7.1); 7.8636 (0.6); 7.1256 (1.8); 7.1052 (7.8); 7.0929 (8.4); 7.0720 (1.8); 7.0253 (0.8); 7.0183 (6.7); 7.0131 (1.8); 7.0011 (1.8); 6.9959 (6.3); 6.9888 (0.5); 4.6458 (1.9); 4.6073 (2.2); 4.3537 (1.1); 4.3430 (2.7); 4.3337 (2.9); 4.3241 (1.6); 4.2367 (3.0); 4.2256 (3.7); 4.2150 (1.8); 4.0487 (2.2); 4.0106 (2.0); 3.7270 (0.7); 3.7165 (1.0); 3.7061 (1.2); 3.6959 (1.0); 3.6856 (0.8); 3.3211 (219.8); 3.2724 (0.8); 3.1693 (2.0); 2.7811 (1.4); 2.7710 (1.5); 2.7413 (1.8); 2.7311 (1.7); 2.6746 (0.7); 2.6699 (0.9); 2.6653 (0.7); 2.5400 (0.5); 2.5233 (2.6); 2.5186 (3.7); 2.5100 (54.7); 2.5054 (118.2); 2.5008 (164.3); 2.4962 (113.4); 2.4916 (50.6); 2.4808 (2.5); 2.4591 (2.1); 2.4411 (1.7); 2.4267 (0.6); 2.4193 (1.7); 2.4087 (0.6); 2.4025 (0.6); 2.3854 (1.1); 2.3670 (0.9); 2.3612 (0.8); 2.3437 (0.8); 2.3322 (0.7); 2.3275 (1.0); 2.3230 (0.7); 2.2596 (16.0); 2.2448 (1.4); 2.2310 (1.3); 2.2143 (0.5); 2.2028 (0.8); 2.1899 (0.8); 2.1344 (0.7); 2.1221 (0.6); 2.1163 (0.5); 2.1094 (0.6); 2.1027 (0.8); 2.0840 (0.5); 2.0780 (0.6); 2.0707 (0.7); 1.7152 (0.6); 1.7036 (0.8); 1.6928 (0.7); 1.6832 (0.7); 1.6718 (0.8); -0.0002 (0.8) I.1-055:1H NMR (400.1 MHz, CDCl3): δ= 7.5192 (0.4); 7.3112 (0.8); 7.2604 (80.4); 7.2118 (0.7); 7.1461 (0.5); 7.1254 (1.1); 7.1215 (0.9); 7.1152 (0.6); 7.1094 (0.6); 7.1050 (0.9); 7.1004 (1.4); 7.0894 (0.8); 7.0803 (1.1); 7.0684 (0.6); 7.0636 (0.6); 6.9966 (1.1); 6.9877 (0.6); 6.9766 (0.6); 6.9738 (0.6); 4.7296 (0.4); 4.6329 (1.3); 4.5946 (1.6); 4.2674 (1.6); 4.2290 (1.3); 4.1073 (0.4); 4.0753 (0.6); 4.0667 (0.8); 4.0555 (1.1); 4.0451 (0.7); 4.0359 (0.6); 3.6587 (3.7); 3.1766 (15.7); 3.1143 (16.0); 2.9657 (1.0); 2.9540 (1.1); 2.9497 (3.7); 2.9235 (1.3); 2.9122 (1.2); 2.8491 (1.8); 2.8357 (1.7); 2.6744 (1.3); 2.6544 (1.2); 2.6324 (1.0); 2.6124 (1.0); 2.5892 (0.6); 2.5776 (0.4); 2.5707 (0.4); 2.5473 (0.9); 2.5276 (1.0); 2.5048 (0.8); 2.4772 (0.6); 2.4635 (0.7); 2.4530 (0.9); 2.4396 (0.9); 2.4344 (0.5); 2.4202 (0.4); 2.4101 (0.5); 2.3973 (0.5); 2.3901 (0.5); 2.3721 (0.5); 2.3536 (0.7); 2.3408 (0.4); 2.3344 (0.4); 2.3300 (0.7); 2.3214 (0.7); 2.3167 (0.4); 2.3011 (0.4); 2.2967 (0.6); 2.0045 (0.4); 1.8379 (0.4); 1.8257 (0.6); 1.8145 (0.7); 1.8047 (0.6); 1.7925 (0.6); 1.7816 (0.6); 1.7700 (0.4); 1.6010 (0.6); 1.5499 (63.7); 1.5012 (0.6); 0.0000 (11.2) I.1-056:1H NMR (400.1 MHz, d6-DMSO): δ= 10.8047 (0.8); 7.3597 (0.5); 7.3554 (0.6); 7.3494 (0.4); 7.3393 (0.4); 7.3335 (0.6); 7.3292 (0.6); 7.3132 (0.3); 7.3092 (0.3); 7.1925 (0.6); 7.1891 (0.6); 7.1797 (0.6); 7.1764 (0.6); 7.1722 (0.5); 7.1684 (0.4); 7.1594 (0.4); 7.1559 (0.4); 7.0987 (0.6); 7.0825 (0.8); 7.0637 (0.4); 4.7545 (0.9); 4.7142 (1.0); 4.3051 (1.1); 4.2654 (1.0); 3.9296 (0.4); 3.9189 (0.5); 3.9091 (0.6); 3.8992 (0.5); 3.8886 (0.4); 3.3273 (29.0); 3.1686 (0.6); 2.9026 (0.6); 2.8921 (0.6); 2.8652 (0.7); 2.8547 (0.7); 2.6067 (0.7); 2.5852 (0.7); 2.5689 (0.6); 2.5472 (0.8); 2.5401 (0.4); 2.5233 (0.8); 2.5185 (1.2); 2.5100 (17.2); 2.5055 (37.2); 2.5008 (51.8); 2.4963 (37.8); 2.4918 (18.8); 2.4465 (0.5); 2.4223 (0.7); 2.4041 (0.6); 2.3994 (0.6); 2.3825 (0.4); 2.3321 (0.6); 2.3280 (0.4); 2.3190 (0.6); 2.3079 (0.8); 2.2951 (0.8); 2.2687 (16.0); 2.2564 (1.1); 2.2398 (0.6); 2.2279 (0.5); 2.2214 (0.4); 2.2093 (0.6); 2.1898 (0.4); 2.1847 (0.4); 1.8520 (0.4); 1.8404 (0.5); 1.8300 (0.4); 1.8225 (0.5); 1.8096 (0.4); 1.1588 (0.4) I.1-057:1H NMR (400.0MHz, d6-DMSO): δ= 7.3344 (5.4); 7.3292 (1.8); 7.3174 (1.8); 7.3120 (6.2); 7.3031 (0.6); 7.1299 (1.9); 7.1094 (7.6); 7.0967 (8.1); 7.0761 (1.9); 6.9719 (0.6); 6.9632 (6.0); 6.9580 (1.9); 6.9462 (1.7); 6.9408 (5.4); 4.6497 (2.0); 4.6116 (2.3); 4.3234 (1.2); 4.3131 (3.2); 4.3032 (3.2); 4.2938 (1.6); 4.1501 (3.1); 4.1388 (4.5); 4.1278 (2.4); 4.0492 (2.3); 4.0111 (2.1); 3.7237 (0.7); 3.7131 (1.1); 3.7028 (1.2); 3.6927 (1.1); 3.6822 (0.8); 3.4331 (6.7); 2.7809 (1.3); 2.7708 (1.3); 2.7411 (1.7); 2.7310 (1.6); 2.5061 (18.9); 2.5018 (25.9); 2.4975 (19.1); 2.4782 (1.8); 2.4564 (1.7); 2.4384 (1.4); 2.4310 (0.5); 2.4166 (1.6); 2.4065 (0.6); 2.3887 (1.2); 2.3706 (0.9); 2.3651 (0.9); 2.3471 (0.8); 2.2631 (16.0); 2.2485 (1.3); 2.2345 (1.2); 2.2066 (0.7); 2.1932 (0.7); 2.1336 (0.7); 2.1208 (0.6); 2.1151 (0.5); 2.1087 (0.6); 2.1022 (0.9); 2.0831 (0.5); 2.0774 (0.6); 1.7120 (0.7); 1.7004 (0.8); 1.6892 (0.7); 1.6801 (0.7); 1.6686 (0.7); 1.6564 (0.5) I.1-058:1H NMR (400.1 MHz, i.e6-DMSO): δ= 7.5589 (2.7); 7.5544 (3.4); 7.5384 (4.3); 7.5334 (4.0); 7.3988 (4.8); 7.3785 (4.1); 7.3562 (1.0); 7.3360 (1.1); 7.3116 (0.8); 7.2081 (0.6); 7.1879 (1.1); 7.1764 (1.1); 7.1545 (0.6); 7.0864 (0.7); 7.0631 (1.2); 7.0577 (0.8); 4.7215 (0.8); 4.7116 (1.0); 4.6810 (1.0); 4.6709 (1.0); 4.3054 (0.3); 4.2746 (1.5); 4.2625 (2.1); 4.2557 (2.8); 4.2503 (1.9); 4.2446 (1.7); 4.2315 (1.8); 4.2204 (0.6); 4.1930 (1.3); 4.0877 (0.6); 4.0744 (0.6); 3.7487 (0.9); 3.7366 (0.9); 3.7194 (0.6); 3.4608 (0.9); 3.4103 (1.4); 3.3630 (9.7); 3.3123 (1240.8); 3.2884 (22.2); 3.2619 (8.4); 3.2432 (0.9); 3.2298 (1.2); 3.2139 (2.2); 3.2093 (0.6); 3.1956 (1.2); 3.1910 (0.9); 3.1753 (2.9); 3.1622 (2.3); 3.0761 (0.7); 3.0673 (1.2); 3.0544 (0.7); 3.0481 (0.8); 3.0412 (0.6); 3.0327 (0.8); 3.0134 (0.5); 2.9124 (0.4); 2.6973 (0.8); 2.6875 (1.4); 2.6787 (1.6); 2.6741 (2.1); 2.6697 (2.8); 2.6647 (2.1); 2.6574 (1.4); 2.6477 (2.0); 2.6375 (1.0); 2.5989 (0.7); 2.5948 (0.8); 2.5600 (2.4); 2.5558 (3.2); 2.5513 (3.4); 2.5466 (1.5); 2.5228 (4.0); 2.5182 (6.8); 2.5096 (153.0); 2.5051 (339.6); 2.5005 (481.2); 2.4959 (349.1); 2.4913 (165.5); 2.4592 (1.8); 2.4545 (2.7); 2.4501 (4.0); 2.4458 (3.5); 2.4410 (2.4); 2.4320 (2.1); 2.4201 (1.6); 2.4119 (2.1); 2.3986 (1.3); 2.3920 (1.4); 2.3793 (1.2); 2.3643 (16.0); 2.3492 (1.3); 2.3364 (1.1); 2.3320 (2.1); 2.3273 (2.9); 2.3229 (2.1); 2.2906 (0.8); 2.2778 (0.9); 2.2662 (1.3); 2.2536 (1.4); 2.2246 (0.9); 2.2136 (1.2); 2.1977 (0.7); 2.1852 (0.7); 2.1599 (0.8); 2.1408 (0.7); 2.1175 (0.4); 2.0722 (2.2); 1.7320 (0.6); 1.7230 (0.6); 1.7119 (0.8); 1.7010 (0.8); 1.6928 (0.8); 1.6804 (0.6); 1.6692 (0.6); 0.1456 (0.4); 0.0505 (0.8); 0.0080 (2.6); 0.0000 (84.3) I.1-060:1H NMR (400.1 MHz, CDCl3): δ= 7.5205 (0.8); 7.5184 (1.0); 7.3836 (4.8); 7.3802 (6.7); 7.3780 (7.9); 7.3728 (3.4); 7.3647 (6.2); 7.3626 (9.5); 7.3602 (12.8); 7.3158 (3.9); 7.3137 (6.6); 7.3115 (5.7); 7.3064 (3.9); 7.3038 (3.6); 7.2954 (11.8); 7.2935 (11.2); 7.2898 (7.2); 7.2847 (5.3); 7.2726 (17.3); 7.2687 (14.4); 7.2679 (14.2); 7.2617 (127.9); 7.2596 (163.4); 7.2520 (4.3); 7.2374 (4.0); 7.2350 (4.6); 7.2317 (2.6); 7.2225 (2.2); 7.2181 (5.5); 7.2014 (1.6); 7.1987 (1.6); 7.1957 (0.7); 6.9979 (5.7); 6.9803 (6.2); 6.9662 (3.2); 6.9599 (3.8); 6.9357 (3.6); 6.9308 (3.4); 6.9066 (3.3); 4.8227 (5.4); 4.7839 (6.0); 4.2467 (0.8); 4.2355 (7.4); 4.2185 (15.0); 4.2017 (7.6); 4.1191 (5.9); 4.0805 (5.4); 3.8792 (1.0); 3.8677 (2.0); 3.8583 (2.8); 3.8475 (3.6); 3.8370 (2.7); 3.8267 (1.9); 3.8156 (0.9); 3.1215 (1.1); 3.1097 (8.5); 3.0929 (16.0); 3.0761 (7.5); 2.5906 (3.5); 2.5797 (3.2); 2.5516 (4.9); 2.5411 (5.3); 2.5171 (3.0); 2.4986 (2.8); 2.4934 (2.6); 2.4747 (2.6); 2.4569 (2.3); 2.4421 (2.7); 2.4326 (3.1); 2.4179 (3.1); 2.3993 (1.0); 2.3896 (1.4); 2.3751 (1.3); 2.3281 (4.4); 2.3068 (4.4); 2.2966 (1.6); 2.2891 (3.6); 2.2781 (2.4); 2.2677 (4.0); 2.2581 (1.6); 2.2539 (1.8); 2.2455 (2.3); 2.2343 (1.1); 2.2256 (1.4); 2.2214 (1.7); 2.2014 (0.8); 1.8383 (1.2); 1.8264 (1.8); 1.8142 (2.1); 1.8051 (2.1); 1.8026 (2.0); 1.7933 (1.9); 1.7908 (2.0); 1.7814 (1.7); 1.7696 (1.3); 1.7558 (0.8); 1.5457 (59.1); 0.1465 (0.3); 0.0128 (4.6); 0.0081 (5.4); 0.0022 (47.7) I.1-063:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.6522 (1.8); 7.3660 (0.5); 7.3440 (0.5); 7.1951 (0.6); 7.1916 (0.6); 7.1822 (0.5); 7.1791 (0.6); 7.0874 (0.6); 7.0714 (0.8); 4.7420 (0.8); 4.7023 (1.0); 4.2438 (1.1); 4.2040 (0.9); 3.7934 (0.6); 3.7833 (0.7); 3.7732 (0.6); 3.5596 (16.0); 2.5201 (0.8); 2.5114 (10.1); 2.5068 (20.3); 2.5023 (28.0); 2.4977 (19.8); 2.4932 (8.8); 2.4767 (1.0); 2.4654 (0.7); 2.3728 (0.6); 2.3527 (0.6); 2.3297 (0.6); 2.2782 (0.5); 2.2670 (0.6); 2.2542 (0.6); 2.1999 (0.9); 2.1782 (0.8); 2.1650 (0.8); 2.1431 (0.9); 1.3492 (1.4); 1.3385 (1.4); 1.3292 (1.3); 1.1744 (0.7); 0.9786 (0.7); 0.9733 (1.3); 0.9694 (1.8); 0.9612 (1.6); 0.9516 (0.5); -0.0002 (5.4) I.1-066:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.3541 (0.8); 7.3510 (1.4); 7.3471 (0.6); 7.3382 (0.9); 7.3338 (3.7); 7.3302 (2.0); 7.3185 (1.3); 7.3151 (3.2); 7.3133 (2.2); 7.3100 (0.6); 7.2830 (0.6); 7.2794 (1.4); 7.2759 (1.0); 7.2612 (1.7); 7.2430 (0.6); 7.2260 (2.6); 7.2223 (3.2); 7.2170 (0.7); 7.2054 (2.3); 4.6882 (1.6); 4.6495 (1.8); 4.1239 (1.8); 4.0852 (1.6); 4.0367 (1.4); 4.0194 (4.2); 4.0189 (4.3); 4.0015 (4.6); 3.9837 (1.7); 3.9423 (1.5); 3.7579 (0.6); 3.7473 (0.9); 3.7372 (1.0); 3.7271 (0.9); 3.7166 (0.6); 3.4648 (0.5); 3.4473 (1.6); 3.4298 (1.6); 3.4123 (0.5); 2.7387 (1.3); 2.7283 (1.3); 2.6990 (1.7); 2.6887 (1.6); 2.5192 (0.6); 2.5105 (8.6); 2.5059 (18.5); 2.5013 (25.8); 2.4967 (18.0); 2.4921 (8.0); 2.4473 (2.1); 2.4307 (0.5); 2.4256 (2.2); 2.4076 (2.3); 2.3859 (1.9); 2.3662 (0.6); 2.3064 (0.7); 2.2926 (0.8); 2.2819 (1.1); 2.2682 (1.1); 2.2648 (0.5); 2.2401 (0.7); 2.2269 (0.7); 2.1761 (0.6); 2.1641 (0.6); 2.1460 (0.7); 1.7250 (0.5); 1.7140 (0.8); 1.7032 (0.5); 1.6936 (0.6); 1.6821 (0.7); 1.1488 (7.2); 1.1311 (16.0); 1.1133 (7.1); 1.0727 (1.6); 1.0552 (3.3); 1.0377 (1.6); - 0.0002 (2.3) I.1-067:1H NMR (400.0 MHz, d6-DMSO): δ= 7.9605 (3.6); 7.3729 (1.6); 7.3521 (3.5); 7.3305 (3.5); 7.3096 (1.9); 7.2064 (2.1); 7.2023 (2.2); 7.1936 (2.1); 7.1865 (3.8); 7.1826 (3.9); 7.1737 (3.7); 7.1701 (4.0); 7.1661 (2.5); 7.1620 (2.3); 7.1533 (2.1); 7.1495 (2.2); 7.0734 (3.7); 7.0576 (5.1); 7.0381 (2.7); 4.7356 (6.1); 4.6957 (7.1); 4.6274 (1.2); 4.2328 (7.4); 4.1925 (6.3); 3.8088 (1.2); 3.7985 (2.3); 3.7883 (3.5); 3.7780 (4.3); 3.7677 (3.6); 3.7572 (2.5); 3.7464 (1.3); 3.3775 (6.7); 3.3624 (14.5); 3.3474 (8.9); 3.3072 (176.5); 3.2559 (1.6); 3.1685 (0.8); 3.1067 (6.0); 3.0920 (16.0); 3.0774 (14.8); 3.0624 (4.8); 2.6739 (2.1); 2.6692 (3.0); 2.6646 (2.1); 2.5395 (2.4); 2.5229 (11.1); 2.5180 (10.8); 2.5094 (174.1); 2.5048 (381.4); 2.5001 (535.0); 2.4955 (370.0); 2.4909 (167.8); 2.4771 (8.4); 2.4502 (2.1); 2.4038 (1.4); 2.3992 (0.5); 2.3855 (2.4); 2.3620 (4.6); 2.3424 (4.2); 2.3316 (2.6); 2.3269 (3.6); 2.3193 (4.0); 2.2776 (3.3); 2.2645 (4.2); 2.2535 (5.2); 2.2406 (4.9); 2.2358 (2.3); 2.2229 (2.1); 2.2124 (8.5); 2.1989 (3.3); 2.1911 (6.4); 2.1779 (5.5); 2.1564 (5.3); 2.1397 (1.9); 2.1202 (3.2); 2.1158 (2.0); 2.1082 (2.3); 2.1010 (2.0); 2.0963 (2.8); 2.0887 (3.9); 2.0770 (1.5); 2.0689 (2.3); 2.0646 (3.0); 2.0451 (1.3); 1.7806 (1.6); 1.7684 (2.2); 1.7572 (3.2); 1.7474 (2.7); 1.7351 (2.7); 1.7253 (2.8); 1.7145 (1.8); 1.7019 (1.2); 0.0080 (1.6); -0.0002 (56.0); -0.0086 (1.8) I.1-069:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1539 (8.0); 7.1387 (6.8); 3.3493 (12.3); 3.3156 (1369.1); 2.6743 (9.8); 2.6696 (14.6); 2.6651 (9.8); 2.5680 (6.2); 2.5390 (19.6); 2.5342 (27.3); 2.5295 (24.1); 2.5233 (41.0); 2.5184 (58.1); 2.5098 (820.2); 2.5053 (1776.1); 2.5007 (2460.2); 2.4961 (1716.3); 2.4915 (763.2); 2.4506 (5.4); 2.3322 (10.2); 2.3275 (14.2); 2.3229 (10.0); 2.0733 (4.4); 1.1833 (8.0); 1.1644 (16.0); 1.1457 (6.6); 0.8936 (8.6); 0.8775 (7.7); 0.8290 (8.3); 0.8125 (7.9); 0.0081 (9.8); -0.0002 (271.7); -0.0086 (6.8) I.1-070:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.9991 (2.5); 8.6323 (0.9); 8.6127 (0.9); 7.4148 (2.3); 7.3595 (0.7); 7.3369 (0.7); 7.1847 (0.7); 7.1725 (0.8); 7.0691 (0.7); 7.0525 (1.0); 4.7152 (1.0); 4.6759 (1.2); 4.6198 (0.5); 4.6103 (0.6); 4.6002 (0.6); 4.5906 (0.5); 4.1730 (1.2); 4.1329 (1.1); 3.7207 (0.6); 3.7100 (0.7); 3.6996 (0.6); 3.6313 (16.0); 3.3542 (134.1); 3.1857 (2.8); 3.1678 (3.3); 3.1510 (0.8); 3.1263 (1.0); 3.1128 (0.9); 3.0374 (1.0); 3.0141 (1.0); 3.0000 (0.7); 2.9763 (0.6); 2.6749 (0.6); 2.6703 (0.8); 2.6656 (0.6); 2.5407 (1.0); 2.5318 (1.2); 2.5238 (2.1); 2.5191 (3.0); 2.5104 (49.9); 2.5058 (108.6); 2.5012 (151.6); 2.4966 (106.3); 2.4920 (47.2); 2.3326 (0.7); 2.3279 (1.1); 2.3232 (1.3); 2.3027 (0.9); 2.2802 (0.7); 2.2720 (1.0); 2.2594 (0.6); 2.2499 (1.1); 2.2362 (1.3); 2.2226 (0.9); 2.2156 (1.0); 2.0292 (0.6); 1.7013 (0.5); 1.6913 (0.5); 0.0080 (0.5); -0.0002 (16.5) I.1-073:1H NMR (400.1 MHz, CDCl3): δ= 17.2398 (0.3); 15.8901 (0.6); 13.9985 (0.3); 7.5185 (3.1); 7.3594 (0.5); 7.3160 (2.6); 7.2977 (5.6); 7.2797 (7.0); 7.2756 (5.4); 7.2598 (550.1); 7.2109 (1.1); 7.1584 (0.4); 7.1530 (0.3); 7.0340 (9.7); 7.0150 (8.7); 6.9950 (4.6); 6.9872 (4.8); 6.9689 (16.0); 6.9464 (13.2); 6.7610 (0.3); 5.5547 (0.4); 5.5395 (0.4); 5.5336 (0.4); 5.5086 (0.7); 5.4873 (1.0); 5.4517 (2.3); 5.4223 (1.6); 5.3933 (1.1); 5.3354 (2.2); 4.8824 (0.4); 4.7450 (11.0); 4.7067 (12.8); 4.2529 (12.2); 4.2145 (10.7); 4.1782 (0.6); 4.1329 (0.3); 4.0453 (2.0); 4.0335 (3.8); 4.0246 (4.4); 4.0132 (7.2); 4.0017 (4.6); 3.9934 (4.1); 3.9814 (2.0); 3.5288 (1.0); 3.4919 (1.4); 2.6255 (0.4); 2.5928 (1.7); 2.5696 (10.0); 2.5575 (8.2); 2.5500 (6.7); 2.5320 (14.2); 2.5201 (10.5); 2.5071 (5.2); 2.4921 (4.9); 2.4776 (5.5); 2.4678 (6.6); 2.4537 (6.9); 2.4350 (1.9); 2.4249 (3.1); 2.4109 (3.4); 2.3933 (0.4); 2.3869 (0.4); 2.3709 (0.4); 2.3588 (2.7); 2.3394 (4.4); 2.3261 (3.2); 2.3205 (2.9); 2.3155 (3.6); 2.3069 (4.9); 2.3020 (3.3); 2.2970 (2.2); 2.2879 (2.9); 2.2830 (4.1); 2.2637 (2.0); 2.2485 (0.4); 2.2262 (9.5); 2.2053 (9.4); 2.1888 (7.9); 2.1678 (7.8); 2.0838 (0.6); 2.0236 (0.9); 2.0138 (1.0); 2.0047 (1.2); 1.8513 (15.7); 1.8395 (14.3); 1.8270 (12.0); 1.8174 (10.1); 1.8042 (8.3); 1.7941 (6.6); 1.7831 (5.3); 1.7694 (3.8); 1.7045 (0.9); 1.6337 (0.5); 1.6220 (0.5); 1.5953 (0.5); 1.5880 (0.4); 1.5504 (0.4); 1.2244 (0.3); 0.9752 (0.3); 0.8624 (0.3); 0.8237 (0.3); 0.1455 (1.0); 0.0999 (0.4); 0.0082 (6.5); 0.0000 (199.3) I.1-074:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.3499 (4.6); 7.3263 (3.6); 7.2640 (9.4); 7.2465 (15.0); 7.2290 (11.4); 7.2168 (13.4); 7.2108 (16.0); 7.1858 (10.8); 7.0363 (4.8); 7.0215 (5.0); 4.6966 (3.6); 4.6769 (3.8); 4.6572 (4.0); 4.6371 (4.5); 4.1809 (3.8); 4.1394 (4.0); 4.1246 (4.5); 4.0843 (3.8); 3.6475 (3.2); 3.3671 (5.4); 3.3151 (6348.8); 3.2642 (17.1); 3.2158 (5.8); 3.1660 (9.5); 3.0520 (4.0); 2.8323 (3.3); 2.8073 (3.9); 2.6744 (25.2); 2.6697 (35.0); 2.6652 (25.8); 2.6607 (11.2); 2.5400 (23.0); 2.5232 (95.7); 2.5185 (141.3); 2.5098 (1948.2); 2.5053 (4233.3); 2.5007 (5926.9); 2.4960 (4148.6); 2.4915 (1849.1); 2.4552 (12.4); 2.4502 (15.1); 2.4457 (12.4); 2.4059 (5.9); 2.3368 (11.6); 2.3321 (24.8); 2.3275 (34.9); 2.3228 (25.0); 2.3185 (12.0); 2.2696 (4.0); 2.2469 (4.7); 2.2272 (4.7); 2.1878 (5.4); 2.1724 (6.5); 2.1649 (6.7); 2.1537 (6.4); 2.0730 (8.0); 0.0080 (20.9); -0.0002 (707.7); -0.0085 (19.0) I.1-075:1H NMR (400.1 MHz, CDCl3): δ= 10.3385 (0.3); 10.3199 (0.4); 7.5193 (1.3); 7.3089 (0.8); 7.2605 (246.9); 7.2126 (0.7); 7.1463 (2.1); 7.1417 (2.4); 7.1220 (7.3); 7.1076 (5.8); 7.1027 (9.1); 7.0973 (6.6); 7.0850 (8.0); 7.0764 (9.5); 7.0680 (9.5); 7.0562 (11.3); 7.0474 (6.5); 7.0363 (6.7); 7.0249 (8.1); 7.0092 (8.8); 6.9966 (4.3); 6.9921 (4.0); 6.7516 (0.5); 5.2983 (4.6); 4.9233 (0.5); 4.8772 (10.9); 4.8384 (12.5); 4.7961 (0.9); 4.3589 (0.4); 4.3341 (1.0); 4.2956 (1.0); 4.2232 (14.4); 4.2064 (1.3); 4.1846 (13.2); 4.1353 (0.9); 4.1194 (0.8); 4.0975 (0.8); 4.0467 (1.3); 4.0344 (1.4); 4.0260 (1.4); 4.0151 (1.4); 3.9968 (3.2); 3.9869 (5.4); 3.9768 (7.7); 3.9668 (9.7); 3.9566 (8.1); 3.9465 (5.9); 3.9367 (3.6); 3.9159 (1.7); 3.9051 (1.7); 3.8947 (1.8); 3.8870 (1.7); 3.8757 (1.7); 3.8439 (1.6); 3.8166 (1.5); 3.8102 (1.5); 3.7902 (1.5); 3.7877 (1.4); 3.7380 (1.3); 3.7195 (1.4); 3.6994 (1.5); 3.6715 (1.5); 3.6530 (1.3); 3.6347 (1.0); 3.6173 (0.8); 3.6084 (0.9); 3.5958 (0.8); 3.5761 (0.8); 3.5599 (0.8); 3.5008 (1.7); 3.4986 (1.7); 3.4934 (2.5); 3.4103 (0.5); 3.3407 (0.9); 3.3205 (0.9); 3.3031 (1.3); 3.2851 (1.9); 3.2672 (2.2); 3.2433 (1.6); 3.1611 (0.3); 3.1358 (1.1); 3.1129 (2.4); 3.1073 (2.3); 3.0368 (0.6); 3.0262 (0.6); 2.9948 (0.6); 2.9840 (0.6); 2.8921 (9.3); 2.8814 (12.8); 2.8768 (13.6); 2.8678 (13.0); 2.8518 (16.0); 2.8415 (12.0); 2.7276 (0.4); 2.7179 (0.8); 2.6992 (0.6); 2.6872 (0.8); 2.6773 (1.1); 2.6563 (11.2); 2.6360 (10.9); 2.6157 (8.6); 2.5955 (10.2); 2.5740 (4.2); 2.5532 (7.4); 2.5315 (8.1); 2.5098 (5.6); 2.4834 (5.0); 2.4711 (6.2); 2.4588 (7.7); 2.4467 (8.0); 2.4406 (3.6); 2.4280 (2.6); 2.4154 (4.0); 2.4036 (4.2); 2.3615 (3.1); 2.3414 (5.3); 2.3288 (3.9); 2.3172 (4.6); 2.3087 (6.2); 2.2971 (2.6); 2.2842 (4.8); 2.2637 (2.0); 2.1833 (0.3); 2.1053 (0.6); 2.0883 (1.7); 2.0689 (2.2); 2.0523 (1.9); 2.0358 (1.0); 2.0077 (1.2); 1.9291 (2.6); 1.9180 (4.4); 1.9066 (4.6); 1.8957 (5.8); 1.8845 (6.1); 1.8739 (4.1); 1.8616 (3.3); 1.8508 (2.2); 1.8346 (0.5); 1.8211 (0.4); 1.8151 (0.4); 1.8012 (0.3); 1.7888 (0.3); 1.3069 (0.6); 1.2888 (1.1); 1.2698 (0.9); 1.2520 (2.9); 1.2339 (4.4); 1.2167 (2.2); 1.1938 (2.2); 1.1757 (4.4); 1.1635 (0.4); 1.1574 (2.0); 1.1493 (0.5); 0.0082 (1.4) I.1-076:1H NMR (400.1 MHz, CDCl3): δ= 7.3161 (0.4); 7.2997 (1.0); 7.2835 (1.1); 7.2606 (55.8); 7.0377 (1.2); 7.0187 (1.1); 6.9961 (0.5); 6.9904 (0.7); 6.9835 (0.7); 6.9635 (2.2); 6.9414 (1.8); 4.8362 (0.4); 4.7974 (0.5); 4.6048 (1.3); 4.5660 (1.9); 4.4097 (1.7); 4.3712 (1.2); 4.1380 (0.5); 4.1015 (0.8); 4.0939 (0.6); 4.0823 (1.1); 4.0708 (0.6); 4.0627 (0.6); 3.6477 (4.5); 3.1311 (15.8); 3.0571 (16.0); 2.9488 (2.6); 2.9164 (0.9); 2.9048 (1.0); 2.8739 (1.3); 2.8621 (1.3); 2.8483 (1.3); 2.8349 (1.3); 2.6712 (1.3); 2.6516 (1.3); 2.6411 (0.3); 2.6290 (1.2); 2.6089 (1.0); 2.6024 (0.5); 2.5905 (0.5); 2.5819 (0.3); 2.5636 (0.9); 2.5449 (0.7); 2.5397 (0.7); 2.5219 (0.7); 2.4921 (0.7); 2.4779 (0.7); 2.4683 (1.0); 2.4541 (1.1); 2.4455 (0.3); 2.4308 (0.3); 2.4253 (0.5); 2.4118 (0.6); 2.3878 (0.8); 2.3697 (0.6); 2.3658 (0.6); 2.3563 (0.4); 2.3474 (0.6); 2.3375 (0.6); 2.3325 (0.4); 2.3271 (0.5); 2.3180 (0.4); 2.3131 (0.4); 2.0039 (0.4); 1.8359 (0.3); 1.8234 (0.5); 1.8116 (0.6); 1.8031 (0.5); 1.7909 (0.5); 1.7793 (0.5); 1.7677 (0.4); 1.5562 (47.4) I.1-078:1H NMR (400.1 MHz, i.e6-DMSO): δ= 7.8196 (0.5); 7.8124 (3.8); 7.8072 (1.1); 7.7951 (1.2); 7.7900 (4.2); 7.7827 (0.4); 7.3591 (0.5); 7.3374 (0.6); 7.3173 (0.4); 7.1875 (0.6); 7.1706 (0.9); 7.1641 (4.3); 7.1589 (1.2); 7.1470 (1.1); 7.1417 (3.7); 7.1341 (0.3); 7.0421 (0.6); 7.0285 (0.8); 7.0072 (0.4); 4.6716 (0.8); 4.6322 (1.1); 4.2422 (1.3); 4.2277 (2.7); 4.2137 (1.5); 4.1731 (1.2); 4.1319 (1.0); 4.0736 (0.3); 3.8581 (0.4); 3.8474 (16.0); 3.6939 (0.3); 3.6832 (0.4); 3.6731 (0.6); 3.6627 (0.8); 3.6537 (0.7); 3.6411 (0.5); 3.6304 (1.3); 3.6176 (1.9); 3.6135 (2.0); 3.6027 (0.9); 3.3624 (2.6); 3.3115 (801.9); 3.2877 (13.5); 3.2626 (2.3); 3.2118 (0.4); 3.1752 (1.4); 3.1621 (1.4); 2.6786 (0.7); 2.6741 (1.2); 2.6696 (1.8); 2.6649 (1.3); 2.6606 (0.7); 2.5622 (1.1); 2.5518 (1.9); 2.5399 (1.4); 2.5230 (4.1); 2.5183 (5.3); 2.5097 (103.1); 2.5051 (228.6); 2.5005 (323.1); 2.4959 (232.4); 2.4913 (109.4); 2.3902 (0.4); 2.3715 (0.4); 2.3480 (0.6); 2.3318 (1.5); 2.3275 (2.4); 2.3228 (1.8); 2.3055 (0.6); 2.2704 (1.1); 2.2652 (0.6); 2.2496 (1.2); 2.2410 (0.8); 2.2300 (1.2); 2.2096 (0.9); 2.1987 (0.4); 2.1859 (0.4); 2.1609 (0.4); 2.1419 (0.4); 2.1291 (0.3); 2.1172 (0.4); 2.1106 (0.5); 2.0911 (0.4); 2.0857 (0.4); 2.0720 (1.1); 1.6402 (0.4); 1.6295 (0.5); 1.6173 (0.5); 1.6068 (0.4); 1.5968 (0.4); 1.5839 (0.3); 0.0081 (1.8) I.1-080:1H NMR (400.0MHz, d6-DMSO): δ= 7.1482 (1.1); 7.1276 (7.2); 7.1217 (6.5); 7.1159 (2.8); 7.1094 (1.1); 7.1003 (1.0); 4.6978 (1.1); 4.6803 (0.6); 4.6602 (1.1); 4.6404 (0.6); 4.0401 (1.0); 4.0332 (0.6); 4.0025 (1.0); 3.9937 (0.7); 3.7296 (0.5); 3.7193 (0.6); 3.7089 (0.6); 3.6982 (0.6); 3.5533 (0.5); 3.4387 (11.3); 3.1677 (16.0); 2.8641 (0.6); 2.8542 (0.6); 2.8246 (0.9); 2.8148 (1.0); 2.6792 (0.6); 2.6699 (0.6); 2.6492 (0.6); 2.6394 (0.6); 2.5641 (1.0); 2.5423 (1.2); 2.5236 (1.8); 2.5187 (2.2); 2.5101 (33.5); 2.5055 (72.8); 2.5009 (101.7); 2.4962 (70.1); 2.4916 (30.6); 2.4217 (1.3); 2.4043 (0.8); 2.3737 (0.8); 2.3596 (0.7); 2.3430 (0.6); 2.3324 (0.6); 2.3277 (0.7); 2.3230 (0.6); 2.2759 (12.8); 2.2644 (1.8); 2.2545 (1.8); 2.2380 (1.5); 2.2100 (0.6); 2.1434 (0.6); 2.1311 (0.5); 2.1249 (0.6); 2.1188 (0.5); 2.1135 (0.6); 2.0994 (0.9); 2.0835 (0.6); 1.6971 (0.6); 1.6515 (0.8); 1.5603 (2.3); 1.5530 (1.9); -0.0002 (8.5) I.1-082:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4699 (1.6); 8.4559 (3.0); 8.4411 (1.6); 7.3769 (1.1); 7.3560 (2.4); 7.3303 (4.7); 7.3282 (4.6); 7.3131 (6.4); 7.3089 (11.2); 7.2963 (3.3); 7.2916 (8.8); 7.2494 (3.7); 7.2465 (3.9); 7.2324 (16.0); 7.2124 (9.7); 7.1939 (1.4); 7.1867 (2.5); 7.1831 (2.6); 7.1706 (2.6); 7.1625 (1.5); 7.1536 (1.3); 7.1502 (1.4); 7.0799 (2.5); 7.0635 (3.4); 7.0444 (1.8); 4.7432 (3.9); 4.7038 (4.6); 4.2954 (1.0); 4.2805 (1.0); 4.2579 (4.8); 4.2411 (12.0); 4.2261 (5.0); 4.2003 (4.7); 4.1884 (1.1); 3.8472 (0.8); 3.8358 (1.6); 3.8257 (2.3); 3.8153 (2.8); 3.8055 (2.3); 3.7948 (1.7); 3.7840 (0.8); 3.3773 (0.6); 3.3248 (216.2); 3.2761 (1.0); 2.6743 (0.6); 2.6697 (0.9); 2.6650 (0.6); 2.6087 (3.2); 2.5975 (3.2); 2.5736 (3.9); 2.5624 (3.9); 2.5230 (2.3); 2.5097 (54.9); 2.5052 (116.5); 2.5006 (160.4); 2.4960 (112.7); 2.4915 (51.7); 2.4555 (0.8); 2.4024 (0.9); 2.3790 (1.3); 2.3597 (2.8); 2.3372 (2.8); 2.3275 (1.2); 2.3181 (2.5); 2.2862 (5.6); 2.2739 (2.7); 2.2637 (6.6); 2.2505 (6.1); 2.2292 (3.6); 2.2213 (1.8); 2.2085 (1.7); 2.1620 (1.2); 2.1429 (2.0); 2.1305 (1.4); 2.1235 (1.3); 2.1190 (1.7); 2.1114 (2.4); 2.0996 (0.9); 2.0918 (1.4); 2.0874 (1.8); 2.0675 (0.7); 1.7986 (1.0); 1.7867 (1.5); 1.7753 (2.0); 1.7652 (1.8); 1.7543 (1.7); 1.7436 (1.9); 1.7326 (1.1); 1.7199 (0.8); -0.0002 (13.6) I.1-083:1H NMR (400.0MHz, d6-DMSO): δ= 7.2319 (0.8); 7.2130 (1.8); 7.1942 (1.2); 7.0829 (1.0); 7.0641 (0.8); 7.0176 (1.8); 6.9881 (0.8); 4.6556 (1.2); 4.6173 (1.3); 4.0613 (1.2); 4.0234 (1.1); 3.7337 (0.7); 3.7231 (0.7); 3.7128 (0.6); 3.7021 (0.5); 3.5530 (16.0); 3.3290 (35.8); 2.7590 (0.8); 2.7487 (0.8); 2.7191 (1.1); 2.7088 (1.0); 2.6709 (0.7); 2.5460 (0.5); 2.5410 (0.6); 2.5242 (1.0); 2.5195 (2.0); 2.5108 (38.5); 2.5063 (84.9); 2.5017 (118.5); 2.4971 (84.1); 2.4926 (38.4); 2.4609 (1.2); 2.4479 (0.5); 2.4391 (1.2); 2.4214 (1.0); 2.4059 (0.8); 2.3993 (1.0); 2.3877 (0.5); 2.3329 (0.6); 2.3285 (0.8); 2.3020 (0.6); 2.2844 (9.6); 2.2641 (0.8); 2.2358 (0.5); 2.1325 (0.6); 1.7011 (0.6); 0.0080 (0.6); -0.0002 (21.7); -0.0085 (0.7) I.1-084:1H NMR (400.0MHz, CDCl3): δ= 7.2602 (57.9); 7.2110 (1.0); 7.1922 (2.4); 7.1734 (1.5); 7.1096 (25.3); 7.0586 (1.3); 7.0396 (1.0); 6.9693 (2.0); 6.9526 (1.2); 6.9326 (1.0); 5.2824 (0.6); 4.7082 (1.7); 4.6707 (2.0); 4.1098 (1.8); 4.0722 (1.6); 3.9416 (0.6); 3.9310 (0.7); 3.9209 (1.0); 3.9109 (0.7); 3.9003 (0.7); 3.5034 (0.8); 3.4857 (1.2); 3.4706 (1.1); 3.4649 (0.6); 3.4532 (0.6); 3.4474 (1.1); 3.4328 (1.2); 3.4156 (0.7); 2.7431 (1.9); 2.7257 (3.8); 2.7084 (1.8); 2.4892 (1.2); 2.4778 (1.3); 2.4616 (0.9); 2.4533 (1.4); 2.4418 (2.1); 2.4192 (0.8); 2.4118 (0.9); 2.3974 (1.0); 2.3876 (1.1); 2.3734 (1.2); 2.3448 (0.6); 2.3267 (12.5); 2.3213 (16.0); 2.1998 (0.7); 2.1866 (0.5); 2.1758 (0.6); 2.1673 (0.9); 2.1625 (0.6); 2.1430 (0.6); 2.0473 (1.5); 2.0259 (1.5); 2.0113 (1.3); 1.9899 (1.3); 1.7553 (0.5); 1.7442 (0.5); 1.7413 (0.6); 1.7306 (0.6); 1.7210 (0.6); 1.7177 (0.5); 1.7082 (0.6); 1.6974 (0.5); -0.0002 (15.0) I.1-085:1H NMR (400.0MHz, d6-DMSO): δ= 7.9206 (0.9); 7.3532 (0.9); 7.3373 (0.6); 7.3318 (0.9); 7.2077 (0.5); 7.2037 (0.6); 7.1949 (0.5); 7.1910 (0.6); 7.1878 (1.0); 7.1840 (1.0); 7.1751 (0.9); 7.1714 (1.0); 7.1675 (0.6); 7.1635 (0.6); 7.1546 (0.5); 7.1509 (0.6); 7.0766 (1.0); 7.0606 (1.3); 7.0574 (1.2); 7.0412 (0.7); 4.7386 (1.5); 4.6988 (1.7); 4.2400 (1.9); 4.2006 (1.6); 3.8045 (0.6); 3.7941 (0.8); 3.7838 (1.1); 3.7737 (0.8); 3.7633 (0.6); 3.3076 (49.6); 2.8956 (0.6); 2.8783 (1.6); 2.8613 (1.7); 2.8458 (1.5); 2.8284 (1.5); 2.8120 (1.4); 2.7942 (0.6); 2.5308 (1.4); 2.5229 (1.3); 2.5185 (2.5); 2.5096 (26.9); 2.5050 (59.5); 2.5004 (84.1); 2.4958 (59.9); 2.4912 (26.4); 2.3598 (1.1); 2.3406 (1.0); 2.3368 (1.1); 2.3272 (0.6); 2.3179 (1.0); 2.2882 (0.9); 2.2746 (1.1); 2.2641 (1.3); 2.2507 (1.3); 2.2465 (0.6); 2.2217 (2.1); 2.2090 (0.8); 2.1999 (1.6); 2.1867 (1.3); 2.1652 (1.3); 2.1271 (0.8); 2.1149 (0.6); 2.1032 (0.7); 2.0956 (0.9); 2.0910 (0.6); 2.0762 (0.5); 2.0714 (0.9); 1.7676 (0.6); 1.7566 (0.8); 1.7468 (0.6); 1.7355 (0.6); 1.7249 (0.7); 1.6672 (0.6); 1.6504 (1.2); 1.6336 (1.5); 1.6169 (1.2); 1.6000 (0.6); 0.8217 (16.0); 0.8049 (15.4); -0.0002 (8.6) I.1-086:1H NMR (400.1 MHz, i.e6-DMSO): δ= 7.3971 (7.6); 7.3790 (5.0); 7.3751 (4.6); 7.3584 (7.2); 7.3546 (7.8); 7.3484 (4.0); 7.3385 (4.9); 7.3330 (7.7); 7.3287 (6.4); 7.3122 (4.0); 7.3085 (3.7); 7.2099 (4.0); 7.2061 (4.0); 7.1972 (4.2); 7.1900 (7.8); 7.1864 (7.8); 7.1772 (7.6); 7.1739 (8.0); 7.1699 (4.9); 7.1660 (4.5); 7.1569 (4.1); 7.1536 (4.2); 7.0848 (7.8); 7.0687 (10.9); 7.0494 (5.5); 6.9468 (0.5); 6.8974 (7.5); 4.7474 (12.7); 4.7078 (14.6); 4.2404 (16.0); 4.2179 (0.4); 4.2007 (13.8); 3.8023 (2.5); 3.7915 (5.5); 3.7808 (7.4); 3.7706 (8.6); 3.7605 (7.5); 3.7498 (5.8); 3.7391 (2.8); 3.5598 (0.4); 3.5114 (0.4); 3.4589 (1.4); 3.4218 (1.6); 3.4080 (5.7); 3.3602 (1264.3); 3.3020 (0.4); 3.2922 (1.0); 3.2634 (1.2); 3.2470 (0.4); 3.2326 (0.3); 3.2116 (0.4); 3.1693 (2.2); 2.6794 (1.1); 2.6752 (2.3); 2.6707 (3.2); 2.6662 (2.4); 2.6618 (1.1); 2.6048 (0.4); 2.6001 (0.4); 2.5501 (1.4); 2.5455 (1.8); 2.5410 (2.0); 2.5240 (8.5); 2.5192 (12.0); 2.5106 (195.3); 2.5062 (398.9); 2.5016 (545.9); 2.4971 (389.8); 2.4926 (178.1); 2.4744 (16.3); 2.4633 (14.3); 2.4284 (0.4); 2.4105 (3.2); 2.3914 (4.0); 2.3876 (3.9); 2.3686 (9.0); 2.3494 (8.2); 2.3458 (7.5); 2.3379 (2.0); 2.3327 (3.4); 2.3274 (9.0); 2.3030 (0.4); 2.2872 (6.5); 2.2738 (7.6); 2.2631 (9.8); 2.2498 (9.8); 2.2321 (3.1); 2.2212 (5.4); 2.2083 (5.6); 2.1802 (12.7); 2.1658 (4.5); 2.1579 (12.8); 2.1452 (14.5); 2.1345 (5.2); 2.1227 (15.3); 2.1154 (8.3); 2.1107 (4.6); 2.1037 (2.8); 2.0958 (4.4); 2.0912 (5.6); 2.0716 (3.2); 1.7780 (3.3); 1.7662 (4.8); 1.7548 (6.8); 1.7444 (5.6); 1.7339 (5.5); 1.7231 (5.9); 1.7121 (3.8); 1.6993 (2.6) I.1-087:1H NMR (400.0MHz, d6-DMSO): δ= 9.5856 (2.2); 8.3724 (6.0); 7.3845 (3.1); 7.3633 (6.6); 7.3372 (6.3); 7.3175 (3.3); 7.2148 (3.8); 7.1953 (6.8); 7.1823 (6.8); 7.1618 (3.8); 7.0942 (2.6); 7.0802 (7.6); 7.0643 (7.4); 7.0453 (3.5); 4.7768 (3.5); 4.7369 (11.2); 4.6970 (8.8); 4.2390 (10.4); 4.1995 (9.5); 3.8528 (16.0); 3.8078 (14.7); 3.7971 (15.2); 3.7870 (15.8); 3.7764 (13.9); 3.1683 (6.6); 2.8096 (2.7); 2.7991 (2.9); 2.7719 (3.7); 2.7612 (3.8); 2.6747 (4.4); 2.6701 (6.0); 2.6658 (4.1); 2.5791 (115.5); 2.5404 (41.5); 2.5236 (16.2); 2.5189 (24.6); 2.5102 (357.0); 2.5057 (776.9); 2.5010 (1082.2); 2.4964 (752.8); 2.4919 (337.9); 2.4648 (7.9); 2.4539 (9.2); 2.4293 (9.1); 2.4186 (8.3); 2.4028 (6.4); 2.3865 (8.1); 2.3655 (14.1); 2.3543 (29.4); 2.3323 (7.1); 2.3276 (10.4); 2.2978 (4.6); 2.2845 (5.8); 2.2734 (8.1); 2.2606 (7.2); 2.2490 (3.8); 2.2318 (4.8); 2.2194 (4.2); 2.1713 (3.4); 2.1577 (7.3); 2.1368 (9.1); 2.1223 (9.1); 2.1010 (7.9); 2.0731 (2.6); 1.7782 (2.2); 1.7661 (2.9); 1.7541 (4.5); 1.7418 (4.2); 1.7222 (4.4); 0.0081 (7.5); -0.0002 (245.9); -0.0086 (6.7) I.1-088:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.9528 (0.9); 7.1430 (1.8); 7.1228 (7.4); 7.1092 (8.3); 7.0886 (2.1); 4.6659 (1.9); 4.6279 (2.2); 4.0115 (2.2); 3.9736 (2.0); 3.7157 (0.7); 3.7046 (0.9); 3.6942 (1.0); 3.6841 (0.9); 3.6731 (0.8); 3.3815 (4.2); 3.3663 (9.3); 3.3512 (8.0); 3.1683 (0.8); 3.1147 (0.8); 3.1083 (0.9); 3.1001 (2.2); 3.0932 (2.0); 3.0857 (2.1); 3.0786 (1.9); 3.0711 (0.8); 3.0631 (0.8); 2.6691 (0.5); 2.5226 (0.9); 2.5178 (1.4); 2.5092 (31.9); 2.5046 (68.2); 2.5000 (97.1); 2.4954 (68.6); 2.4908 (31.4); 2.4749 (2.3); 2.4637 (2.0); 2.4507 (0.7); 2.3641 (0.6); 2.3458 (1.1); 2.3268 (1.6); 2.3225 (1.3); 2.3036 (0.9); 2.2756 (16.0); 2.2597 (1.1); 2.2462 (1.2); 2.2355 (1.3); 2.2220 (1.3); 2.2044 (0.6); 2.1936 (0.7); 2.1803 (0.7); 2.1403 (1.7); 2.1176 (1.7); 2.1058 (1.4); 2.0832 (1.4); 2.0710 (0.6); 2.0421 (0.8); 2.0295 (0.6); 2.0179 (0.7); 2.0102 (0.9); 1.9909 (0.5); 1.9860 (0.8); 1.7164 (0.6); 1.7056 (0.8); 1.6956 (0.7); 1.6844 (0.7); 1.6737 (0.7); 0.0080 (0.8); -0.0002 (29.7); -0.0085 (0.9) I.1-089:1H NMR (400.0MHz, d6-DMSO): δ= 9.8770 (6.5); 7.8843 (0.6); 7.8775 (4.7); 7.8727 (1.6); 7.8557 (5.1); 7.8490 (0.6); 7.2984 (1.2); 7.2768 (1.3); 7.1347 (4.9); 7.1289 (2.8); 7.1128 (6.2); 7.1065 (8.3); 7.0941 (8.0); 7.0734 (1.8); 6.9279 (1.4); 6.9062 (1.3); 5.3173 (1.5); 4.6472 (2.2); 4.6090 (2.4); 4.3686 (0.8); 4.3583 (2.3); 4.3489 (2.8); 4.3399 (1.9); 4.3303 (0.6); 4.3198 (0.9); 4.3090 (1.0); 4.2860 (2.5); 4.2755 (3.1); 4.2653 (1.4); 4.1537 (0.7); 4.1427 (1.1); 4.1315 (0.6); 4.0484 (2.3); 4.0106 (2.0); 3.7273 (0.7); 3.7165 (1.1); 3.7066 (1.3); 3.6956 (1.1); 3.6853 (0.8); 3.3234 (251.7); 3.2069 (12.7); 3.1674 (6.2); 2.7875 (1.2); 2.7773 (1.2); 2.7477 (1.5); 2.7375 (1.5); 2.6704 (0.7); 2.6662 (0.5); 2.5102 (44.1); 2.5058 (92.5); 2.5013 (126.9); 2.4968 (90.5); 2.4924 (42.3); 2.4664 (1.7); 2.4557 (0.7); 2.4483 (1.3); 2.4376 (0.6); 2.4268 (1.6); 2.4108 (0.7); 2.3863 (1.2); 2.3686 (1.0); 2.3452 (0.8); 2.3281 (0.8); 2.2594 (16.0); 2.2459 (1.4); 2.2321 (1.3); 2.2150 (0.5); 2.2041 (0.8); 2.1909 (0.8); 2.1358 (0.7); 2.1230 (0.6); 2.1038 (0.9); 2.0796 (0.7); 1.7160 (0.7); 1.7043 (0.9); 1.6935 (0.8); 1.6837 (0.8); 1.6725 (0.8); 1.6602 (0.6); -0.0002 (5.5) I.1-090:1H NMR (400.0MHz, d6-DMSO): δ= 8.2264 (1.5); 8.1026 (5.0); 7.3780 (2.4); 7.3742 (2.4); 7.3577 (5.2); 7.3535 (5.7); 7.3321 (5.7); 7.3114 (2.9); 7.3077 (2.9); 7.2081 (3.3); 7.2041 (3.5); 7.1952 (3.4); 7.1882 (6.2); 7.1842 (6.4); 7.1755 (5.8); 7.1718 (6.5); 7.1677 (3.9); 7.1638 (3.8); 7.1551 (3.2); 7.1511 (3.4); 7.0772 (6.1); 7.0611 (8.3); 7.0419 (4.3); 5.8065 (3.2); 5.7932 (7.2); 5.7804 (5.9); 5.7675 (8.2); 5.7635 (4.0); 5.7543 (3.9); 5.7502 (8.7); 5.7373 (6.9); 5.7245 (8.7); 5.7112 (3.8); 5.1305 (4.3); 5.1261 (13.8); 5.1217 (14.7); 5.1173 (4.9); 5.0875 (4.0); 5.0831 (12.3); 5.0786 (12.9); 5.0742 (4.5); 5.0607 (5.2); 5.0567 (14.4); 5.0525 (13.4); 5.0485 (4.6); 5.0350 (4.8); 5.0310 (13.4); 5.0269 (12.8); 5.0229 (4.2); 4.7416 (9.7); 4.7019 (11.2); 4.2382 (12.1); 4.1985 (10.5); 3.8243 (2.0); 3.8132 (4.1); 3.8028 (5.8); 3.7926 (7.3); 3.7824 (5.8); 3.7722 (4.3); 3.7611 (2.0); 3.7060 (0.8); 3.6836 (3.4); 3.6792 (8.0); 3.6746 (9.0); 3.6698 (10.4); 3.6654 (16.0); 3.6609 (15.9); 3.6563 (10.8); 3.6517 (9.9); 3.6472 (8.5); 3.6428 (3.4); 3.6205 (0.9); 3.4150 (2.1); 3.3183 (241.7); 3.1678 (2.0); 2.6739 (2.0); 2.6694 (2.8); 2.6647 (2.1); 2.5597 (8.6); 2.5482 (8.7); 2.5244 (13.4); 2.5180 (10.9); 2.5095 (164.1); 2.5049 (354.0); 2.5003 (494.5); 2.4957 (343.6); 2.4911 (154.5); 2.4061 (2.6); 2.3871 (3.2); 2.3646 (7.2); 2.3449 (6.4); 2.3316 (2.7); 2.3269 (4.0); 2.3223 (7.4); 2.2878 (5.6); 2.2745 (6.7); 2.2637 (8.3); 2.2504 (9.2); 2.2462 (14.5); 2.2327 (3.4); 2.2246 (11.8); 2.2110 (10.6); 2.1896 (8.9); 2.1552 (3.0); 2.1359 (5.4); 2.1313 (2.9); 2.1237 (3.9); 2.1166 (3.1); 2.1119 (4.4); 2.1043 (6.1); 2.0999 (3.6); 2.0926 (2.4); 2.0849 (3.5); 2.0804 (4.6); 2.0712 (1.4); 2.0607 (2.1); 1.7829 (2.5); 1.7705 (3.8); 1.7596 (5.1); 1.7495 (4.3); 1.7386 (4.1); 1.7279 (4.5); 1.7165 (2.8); 1.7041 (2.0); 0.0080 (4.8); -0.0002 (171.8); -0.0085 (4.9); -0.1496 (0.6) I.1-091:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0877 (0.8); 7.4625 (3.8); 7.1364 (1.6); 7.1164 (4.3); 7.0942 (4.7); 7.0738 (1.6); 4.6580 (1.2); 4.6198 (1.4); 4.0077 (3.4); 3.9948 (3.4); 3.9802 (5.1); 3.9622 (4.0); 3.9437 (1.8); 3.7060 (0.6); 3.6959 (0.7); 3.6856 (0.6); 3.4138 (12.6); 2.5224 (1.0); 2.5177 (1.5); 2.5091 (23.8); 2.5045 (52.1); 2.4999 (71.8); 2.4953 (50.3); 2.4908 (22.8); 2.4700 (1.2); 2.4589 (1.1); 2.3271 (1.0); 2.3085 (0.7); 2.2854 (0.7); 2.2734 (10.3); 2.2553 (0.6); 2.2418 (0.7); 2.2312 (0.8); 2.2177 (0.8); 2.1694 (0.9); 2.1419 (1.0); 2.1196 (1.0); 2.1074 (0.9); 2.0851 (0.9); 2.0646 (16.0); 2.0405 (0.5); 2.0088 (0.6); 1.6987 (0.5); 1.3094 (4.5); 1.2913 (9.8); 1.2731 (4.4); 0.0080 (0.7); -0.0002 (22.1); -0.0085 (0.6) I.1-092:1H NMR (400.1 MHz, d6-DMSO): δ= 18.0164 (1.4); 13.3388 (1.8); 13.3093 (1.5); 7.8999 (16.0); 7.8951 (13.8); 7.8905 (8.8); 7.8828 (8.6); 7.7086 (4.5); 7.6871 (5.7); 7.6099 (1.4); 7.5926 (1.7); 7.5876 (1.9); 7.5620 (6.7); 7.5419 (10.4); 7.5217 (4.5); 7.3354 (1.4); 7.1419 (1.9); 7.1186 (1.5); 4.2575 (1.3); 4.2364 (1.7); 4.2203 (1.3); 4.0887 (1.6); 3.8133 (7.7); 3.5541 (9.2); 3.5127 (1.4); 3.4113 (2.2); 3.3672 (6.0); 3.3127 (3071.8); 3.2892 (66.0); 3.2581 (7.5); 3.2125 (2.2); 3.1757 (5.8); 3.1626 (6.1); 2.7009 (1.6); 2.6743 (7.0); 2.6700 (10.2); 2.6656 (7.9); 2.5995 (1.6); 2.5653 (2.4); 2.5232 (16.2); 2.5184 (27.4); 2.5100 (581.6); 2.5055 (1273.4); 2.5010 (1795.9); 2.4965 (1309.0); 2.4919 (630.4); 2.4379 (6.1); 2.4325 (5.1); 2.4073 (3.1); 2.3922 (2.7); 2.3518 (1.6); 2.3320 (8.0); 2.3279 (10.8); 2.3233 (7.8); 2.2795 (1.4); 2.2680 (1.7); 2.0730 (6.6); 0.0077 (3.3) I.1-093:1H NMR (400.0MHz, d6-DMSO): δ= 12.6303 (1.0); 8.2012 (1.0); 8.1780 (1.1); 8.1230 (1.4); 8.0991 (1.2); 7.2096 (7.8); 7.1772 (1.5); 7.1585 (2.3); 7.1247 (3.5); 7.1063 (1.5); 4.7672 (2.4); 4.7291 (2.7); 4.3938 (1.0); 4.3727 (0.9); 4.3050 (0.5); 4.2252 (0.7); 4.2095 (1.0); 4.1892 (0.7); 4.0958 (1.7); 4.0562 (1.6); 3.6843 (1.5); 3.3181 (22.0); 2.6699 (0.7); 2.6273 (1.9); 2.6092 (4.5); 2.5904 (4.5); 2.5710 (2.0); 2.5395 (3.4); 2.5039 (105.7); 2.5005 (106.7); 2.3994 (1.7); 2.3775 (3.1); 2.3554 (2.2); 2.3213 (1.1); 2.2741 (1.2); 2.2475 (1.4); 2.2170 (0.8); 2.0651 (1.0); 2.0343 (1.3); 2.0102 (1.1); 1.8554 (1.0); 1.7756 (1.8); 1.3771 (0.6); 1.2714 (0.7); 1.2563 (1.0); 1.2385 (1.5); 1.1748 (1.3); 1.1561 (2.1); 1.1403 (6.2); 1.1217 (10.5); 1.1030 (5.2); 0.8480 (12.1); 0.8308 (16.0); 0.8139 (4.4); -0.0002 (1.3) I.1-094:1H NMR (400.1 MHz, i.e6-DMSO): δ= 7.1497 (0.9); 7.1292 (5.7); 7.1211 (6.3); 7.1142 (1.7); 7.1099 (1.4); 7.1001 (1.1); 4.6731 (1.3); 4.6352 (1.4); 4.0500 (1.5); 4.0118 (1.3); 3.8004 (0.4); 3.7903 (0.5); 3.7782 (0.6); 3.7680 (0.5); 3.7581 (0.4); 3.5537 (1.0); 3.3067 (99.6); 3.2991 (22.8); 3.2827 (8.7); 3.1157 (16.0); 3.0904 (0.8); 3.0816 (0.8); 3.0472 (1.0); 3.0383 (1.0); 2.8596 (1.2); 2.7968 (1.1); 2.7738 (1.0); 2.7535 (0.9); 2.7306 (0.8); 2.6741 (0.5); 2.6696 (0.7); 2.6650 (0.6); 2.6594 (2.0); 2.5736 (0.7); 2.5230 (1.7); 2.5184 (2.4); 2.5096 (37.7); 2.5051 (83.8); 2.5006 (118.0); 2.4960 (87.2); 2.4916 (42.7); 2.4704 (0.8); 2.4488 (0.6); 2.4442 (0.6); 2.4260 (0.8); 2.4041 (0.7); 2.3841 (0.5); 2.3365 (0.3); 2.3319 (0.6); 2.3274 (0.9); 2.3229 (0.6); 2.2752 (12.0); 2.2631 (0.9); 2.2497 (0.8); 2.2381 (0.8); 2.2331 (0.4); 2.2081 (0.5); 2.1972 (0.6); 2.1764 (0.3); 2.1573 (0.5); 2.1452 (0.4); 2.1380 (0.3); 2.1325 (0.4); 2.1257 (0.6); 2.1012 (0.4); 1.7143 (0.5); 1.7036 (0.4); 1.6922 (0.6); 1.6825 (0.6); 1.6723 (0.4); 1.6596 (0.4); 0.0000 (1.0) I.1-095:1H NMR (400.0 MHz, CDCl3): δ= 7.5205 (0.6); 7.3304 (3.0); 7.3275 (5.3); 7.3236 (2.3); 7.3144 (3.3); 7.3101 (14.1); 7.3066 (7.6); 7.2947 (4.5); 7.2913 (11.2); 7.2616 (106.7); 7.2527 (5.8); 7.2493 (3.7); 7.2398 (1.9); 7.2343 (6.8); 7.2282 (1.6); 7.2193 (1.2); 7.2160 (2.1); 7.2119 (1.2); 7.1788 (9.8); 7.1750 (12.6); 7.1580 (9.3); 7.1173 (1.0); 7.1073 (1.5); 7.1021 (1.3); 7.0926 (3.5); 7.0801 (2.3); 7.0768 (2.4); 7.0740 (2.7); 7.0672 (3.0); 7.0646 (2.9); 7.0595 (1.6); 7.0496 (3.7); 7.0450 (7.6); 7.0380 (9.4); 7.0350 (6.1); 7.0294 (10.4); 7.0193 (4.9); 7.0085 (0.8); 7.0021 (0.7); 6.9976 (0.6); 5.4089 (2.2); 4.8403 (4.6); 4.8368 (4.5); 4.8016 (5.2); 4.7980 (5.1); 4.2210 (6.7); 4.1822 (6.0); 3.9311 (1.1); 3.9200 (2.3); 3.9090 (2.8); 3.8985 (3.2); 3.8890 (2.8); 3.8781 (2.3); 3.8670 (1.1); 3.5569 (0.9); 3.5405 (2.8); 3.5231 (5.7); 3.5112 (6.2); 3.5083 (6.2); 3.4964 (5.7); 3.4911 (3.1); 3.4795 (2.8); 3.4626 (0.9); 2.8151 (8.1); 2.7978 (16.0); 2.7805 (7.4); 2.5736 (4.6); 2.5627 (4.6); 2.5376 (5.4); 2.5267 (5.2); 2.5042 (1.0); 2.4846 (1.3); 2.4811 (1.2); 2.4610 (3.5); 2.4416 (3.2); 2.4380 (3.0); 2.4187 (3.0); 2.4067 (3.4); 2.3920 (3.8); 2.3826 (4.6); 2.3681 (4.6); 2.3640 (1.7); 2.3492 (1.2); 2.3397 (2.0); 2.3253 (2.0); 2.2579 (1.7); 2.2389 (2.8); 2.2341 (1.6); 2.2253 (2.0); 2.2198 (1.7); 2.2149 (2.3); 2.2063 (3.1); 2.2013 (1.8); 2.1960 (1.2); 2.1871 (1.8); 2.1821 (2.4); 2.1631 (1.2); 2.1082 (5.8); 2.0858 (5.7); 2.0722 (5.1); 2.0498 (4.9); 1.8087 (1.5); 1.7974 (1.7); 1.7946 (1.9); 1.7838 (2.2); 1.7741 (2.1); 1.7709 (1.8); 1.7647 (1.7); 1.7614 (2.1); 1.7504 (1.8); 1.7411 (1.5); 1.7381 (1.3); 1.7265 (1.2); 1.6036 (6.9); 0.0079 (1.1); -0.0002 (33.8); -0.0085 (0.9) I.1-096:1H NMR (400.0MHz, d6-DMSO): δ= 7.1263 (1.9); 7.1059 (7.1); 7.0921 (7.6); 7.0715 (1.9); 6.9333 (3.9); 6.9103 (1.7); 6.7949 (3.1); 6.7748 (2.3); 4.6540 (1.9); 4.6160 (2.2); 4.3312 (1.2); 4.3206 (3.2); 4.3099 (3.2); 4.2999 (1.4); 4.0953 (2.9); 4.0839 (4.4); 4.0725 (2.3); 4.0428 (2.2); 4.0046 (1.9); 3.7191 (0.6); 3.7086 (1.0); 3.6982 (1.1); 3.6877 (1.0); 3.6772 (0.7); 3.3256 (163.1); 2.7850 (1.3); 2.7750 (1.3); 2.7453 (1.7); 2.7354 (1.6); 2.6703 (0.6); 2.5099 (34.5); 2.5056 (71.2); 2.5012 (96.6); 2.4967 (68.4); 2.4924 (31.6); 2.4628 (1.9); 2.4407 (1.7); 2.4233 (1.8); 2.4011 (1.8); 2.3819 (1.1); 2.3638 (0.9); 2.3583 (0.8); 2.3402 (0.8); 2.3279 (0.6); 2.2630 (15.3); 2.2426 (1.2); 2.2288 (1.2); 2.2117 (0.6); 2.1905 (15.6); 2.1248 (0.7); 2.1121 (0.6); 2.1001 (0.6); 2.0940 (0.8); 2.0737 (0.8); 2.0685 (0.8); 2.0560 (16.0); 1.7078 (0.6); 1.6962 (0.8); 1.6853 (0.7); 1.6756 (0.7); 1.6641 (0.7); -0.0002 (6.5) I.1-097:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.2750 (2.0); 8.2700 (2.5); 7.6771 (1.2); 7.6708 (1.4); 7.6565 (1.6); 7.6502 (1.8); 7.5218 (0.7); 7.5013 (0.6); 7.4833 (2.4); 7.4628 (2.0); 7.3544 (0.7); 7.3334 (0.8); 7.3127 (0.5); 7.1858 (0.7); 7.1728 (0.8); 7.1560 (0.5); 7.0954 (0.7); 7.0792 (0.9); 4.7492 (1.0); 4.7097 (1.2); 4.5538 (1.6); 4.5216 (0.6); 4.4838 (2.3); 4.4599 (2.4); 4.4220 (0.7); 4.2795 (1.2); 4.2402 (1.1); 3.8949 (0.6); 3.8855 (0.7); 3.8733 (0.6); 3.8641 (0.6); 3.5216 (4.3); 3.1666 (0.6); 2.8917 (16.0); 2.8742 (0.8); 2.8433 (1.0); 2.8333 (1.0); 2.7526 (3.9); 2.6704 (0.6); 2.5962 (1.0); 2.5741 (1.0); 2.5552 (0.8); 2.5329 (0.8); 2.5238 (1.3); 2.5192 (1.9); 2.5105 (33.8); 2.5059 (74.9); 2.5013 (105.5); 2.4967 (74.0); 2.4921 (33.0); 2.4549 (0.5); 2.4312 (0.8); 2.4139 (0.7); 2.3281 (0.7); 2.3236 (0.6); 2.2685 (0.5); 2.2555 (0.9); 2.2437 (0.9); 2.2162 (1.4); 2.2074 (1.0); 2.1996 (0.9); 2.1813 (0.9); 1.7027 (0.6); 0.0080 (1.3); -0.0002 (48.4); -0.0085 (1.4) I.1-098:1H NMR (400.0MHz, d6-DMSO): δ= 8.2967 (0.6); 8.2773 (0.6); 7.1459 (0.6); 7.1252 (3.8); 7.1179 (3.5); 7.1133 (1.3); 7.0967 (0.6); 4.6628 (0.8); 4.6247 (0.8); 4.0256 (0.8); 3.9880 (0.6); 3.5388 (0.8); 2.5351 (0.5); 2.5107 (4.7); 2.5061 (10.3); 2.5015 (14.4); 2.4969 (10.1); 2.4923 (4.9); 2.4796 (0.5); 2.4719 (0.8); 2.4522 (0.7); 2.2762 (6.9); 2.0270 (16.0) I.1-099:1H NMR (400.0MHz, d6-DMSO): δ= 7.9665 (0.6); 7.9501 (0.6); 7.3617 (0.6); 7.3579 (0.7); 7.3359 (0.7); 7.3317 (0.6); 7.1908 (0.7); 7.1872 (0.7); 7.1781 (0.7); 7.1747 (0.7); 7.0763 (0.5); 7.0600 (0.8); 4.7313 (0.7); 4.6909 (0.8); 4.2301 (1.4); 4.1901 (1.2); 4.0786 (0.6); 4.0619 (0.7); 4.0456 (0.6); 3.7653 (0.6); 3.7550 (0.5); 3.5995 (1.3); 3.5639 (16.0); 3.5626 (15.0); 2.5196 (0.6); 2.5109 (9.7); 2.5064 (21.4); 2.5017 (29.9); 2.4971 (20.7); 2.4925 (9.2); 2.4816 (1.0); 2.4754 (0.7); 2.4707 (0.7); 2.4644 (1.2); 2.4478 (1.0); 2.4432 (1.3); 2.4361 (0.8); 2.4272 (1.8); 2.4104 (1.0); 2.3955 (1.2); 2.3923 (1.3); 2.3784 (1.3); 2.3749 (1.4); 2.3544 (1.0); 2.3406 (0.5); 2.3369 (0.9); 2.3316 (0.7); 2.2648 (0.8); 2.2541 (0.6); 2.1673 (0.6); 2.1502 (0.7); 2.1460 (0.7); 2.1326 (0.8); 2.1287 (0.7); 2.1153 (0.9); 2.1114 (1.0); 2.0938 (0.8); 2.0804 (0.5); 1.7412 (0.5); 1.7306 (0.6); 1.0617 (6.8); 1.0450 (6.7); -0.0002 (6.2) I.1-100:1H NMR (400.0MHz, d6-DMSO): δ= 7.9170 (0.8); 7.1447 (1.4); 7.1243 (6.4); 7.1124 (7.1); 7.0916 (1.5); 4.6721 (1.7); 4.6341 (1.8); 4.0192 (1.8); 3.9813 (1.7); 3.7170 (0.6); 3.7060 (0.8); 3.6954 (0.9); 3.6855 (0.8); 3.6746 (0.7); 3.5626 (4.8); 2.9018 (0.5); 2.8848 (1.3); 2.8679 (1.4); 2.8524 (1.1); 2.8481 (1.0); 2.8331 (1.3); 2.8166 (1.2); 2.5204 (1.3); 2.5100 (9.1); 2.5054 (17.6); 2.5008 (24.4); 2.4962 (17.1); 2.4917 (7.9); 2.4869 (1.9); 2.4754 (1.4); 2.3460 (0.9); 2.3274 (0.9); 2.3232 (0.9); 2.3040 (0.7); 2.2756 (13.3); 2.2559 (1.0); 2.2457 (1.1); 2.2317 (1.0); 2.2038 (0.6); 2.1900 (0.5); 2.1466 (1.3); 2.1239 (1.3); 2.1123 (1.2); 2.0896 (1.1); 2.0461 (0.6); 2.0219 (0.6); 2.0145 (0.7); 1.9902 (0.6); 1.7078 (0.6); 1.6973 (0.6); 1.6865 (0.6); 1.6729 (0.7); 1.6555 (1.1); 1.6388 (1.3); 1.6220 (1.0); 1.6052 (0.5); 0.8248 (16.0); 0.8081 (15.4) I.1-101:1H NMR (400.1 MHz, CDCl3): δ= 7.3082 (0.4); 7.2935 (0.7); 7.2896 (0.9); 7.2866 (0.7); 7.2832 (0.3); 7.2743 (1.2); 7.2719 (1.1); 7.2701 (1.0); 7.2694 (1.0); 7.2652 (9.4); 7.2636 (9.2); 7.2612 (38.5); 7.2569 (1.0); 7.2560 (0.9); 7.2551 (0.9); 7.2535 (0.7); 7.2528 (0.7); 7.0240 (1.2); 7.0043 (1.1); 6.9972 (0.4); 6.9799 (0.4); 6.9760 (0.6); 6.9575 (2.0); 6.9546 (1.8); 6.9348 (1.5); 5.9943 (0.5); 4.7366 (1.3); 4.6981 (1.5); 4.2094 (1.4); 4.1709 (1.2); 4.0121 (0.5); 4.0037 (0.6); 4.0002 (0.4); 3.9920 (0.9); 3.9834 (0.5); 3.9801 (0.5); 3.9718 (0.5); 3.7384 (0.4); 3.7006 (16.0); 3.6478 (2.1); 3.5074 (0.3); 3.5032 (0.5); 3.4884 (1.2); 3.4736 (1.6); 3.4708 (1.4); 3.4579 (1.0); 3.4558 (1.2); 3.4410 (0.5); 2.5367 (0.4); 2.5336 (0.4); 2.5191 (2.0); 2.5146 (1.2); 2.5053 (3.1); 2.5032 (2.9); 2.4898 (3.0); 2.4699 (0.9); 2.4655 (1.2); 2.4537 (1.6); 2.4398 (0.7); 2.4302 (1.0); 2.4157 (0.9); 2.4118 (0.4); 2.3874 (0.6); 2.3730 (0.4); 2.2989 (0.4); 2.2797 (0.6); 2.2749 (0.4); 2.2663 (0.5); 2.2605 (0.4); 2.2556 (0.5); 2.2473 (0.7); 2.2422 (0.4); 2.2279 (0.4); 2.2231 (0.5); 2.1428 (1.1); 2.1222 (1.1); 2.1063 (1.0); 2.0857 (0.9); 2.0430 (1.1); 1.8157 (0.3); 1.8044 (0.4); 1.8014 (0.4); 1.7920 (0.5); 1.7828 (0.5); 1.7808 (0.5); 1.7777 (0.4); 1.7715 (0.4); 1.7687 (0.5); 1.7664 (0.4); 1.7595 (0.4); 1.7573 (0.4); 1.7481 (0.4); 1.5714 (7.4); 1.2763 (0.3); 1.2585 (0.8); 1.2406 (0.3); 0.0082 (0.5); 0.0040 (3.4); 0.0026 (3.5) I.1-102:1H NMR (400.6 MHz, d6-DMSO): δ= 7.3795 (5.3); 7.3676 (1.7); 7.3605 (14.0); 7.3496 (2.0); 7.3425 (15.5); 7.3414 (16.0); 7.3348 (8.3); 7.3305 (13.4); 7.3259 (10.3); 7.3149 (3.2); 7.3097 (5.0); 7.3059 (3.3); 7.2841 (10.2); 7.2800 (14.6); 7.2018 (6.5); 7.1979 (10.2); 7.1839 (5.1); 7.1799 (7.9); 7.1763 (4.2); 5.6573 (2.8); 4.6623 (0.6); 4.6264 (9.3); 4.5875 (10.5); 4.1509 (10.5); 4.1119 (9.0); 3.7883 (1.7); 3.7772 (3.5); 3.7662 (4.5); 3.7574 (4.6); 3.7550 (4.7); 3.7463 (4.4); 3.7353 (3.5); 3.7244 (1.7); 3.1845 (0.8); 3.1677 (0.9); 2.7072 (0.5); 2.6761 (0.8); 2.6716 (1.1); 2.6670 (1.3); 2.6533 (6.7); 2.6425 (6.8); 2.6152 (8.2); 2.6044 (7.8); 2.5252 (4.0); 2.5205 (5.7); 2.5119 (47.2); 2.5074 (96.1); 2.5028 (130.0); 2.4982 (89.2); 2.4936 (39.4); 2.4240 (1.9); 2.4055 (2.5); 2.4002 (2.4); 2.3821 (5.4); 2.3638 (4.4); 2.3586 (4.0); 2.3406 (4.2); 2.3299 (1.1); 2.3253 (0.8); 2.3201 (0.8); 2.3023 (0.7); 2.2891 (4.0); 2.2752 (4.9); 2.2649 (6.0); 2.2510 (6.3); 2.2426 (8.1); 2.2338 (2.9); 2.2201 (8.2); 2.2096 (4.4); 2.2045 (6.8); 2.1820 (6.4); 2.1672 (2.5); 2.1485 (3.5); 2.1432 (2.3); 2.1357 (2.9); 2.1299 (2.5); 2.1240 (3.0); 2.1171 (4.0); 2.1116 (2.6); 2.1058 (1.8); 2.0981 (2.5); 2.0926 (2.9); 2.0859 (0.8); 2.0740 (2.0); 1.7250 (2.1); 1.7120 (3.0); 1.7010 (4.0); 1.6903 (3.3); 1.6802 (3.2); 1.6768 (2.6); 1.6691 (3.4); 1.6583 (2.2); 1.6447 (1.5); 0.0080 (1.3); -0.0002 (40.5); -0.0085 (1.2) I.1-103:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.9518 (0.5); 7.9324 (0.5); 7.1448 (1.3); 7.1245 (4.8); 7.1104 (4.2); 7.0898 (1.2); 4.6514 (0.9); 4.6133 (1.0); 4.0834 (0.6); 4.0658 (0.7); 4.0476 (0.6); 4.0150 (1.0); 3.9773 (0.9); 3.7087 (1.1); 3.7025 (1.1); 3.6979 (1.2); 3.6890 (1.2); 3.6788 (1.0); 3.6717 (0.8); 3.6606 (0.6); 3.5587 (16.0); 2.5104 (6.4); 2.5058 (14.0); 2.5012 (19.6); 2.4966 (13.6); 2.4920 (6.0); 2.4826 (0.5); 2.4651 (0.6); 2.4604 (0.9); 2.4575 (0.7); 2.4448 (1.5); 2.4371 (0.6); 2.4270 (1.5); 2.4230 (1.6); 2.4116 (0.7); 2.4057 (1.0); 2.3974 (1.1); 2.3934 (1.0); 2.3804 (1.2); 2.3763 (1.1); 2.3594 (0.7); 2.3558 (0.5); 2.3422 (0.8); 2.3390 (0.6); 2.3165 (0.6); 2.2756 (10.3); 2.2476 (0.6); 2.2387 (0.5); 2.2251 (0.6); 2.0862 (0.6); 2.0645 (1.0); 2.0517 (0.7); 2.0422 (0.6); 2.0304 (1.1); 2.0074 (0.8); 1.0636 (3.9); 1.0607 (4.6); 1.0468 (4.0); 1.0439 (4.5); -0.0002 (5.4) I.1-104:1H NMR (400.1 MHz, CDCl3): δ= 7.5231 (0.6); 7.5199 (0.6); 7.2643 (96.1); 7.2611 (98.2); 7.1288 (0.4); 7.1156 (0.9); 7.1039 (1.4); 7.0955 (1.2); 7.0877 (1.6); 7.0791 (1.8); 7.0607 (6.4); 7.0531 (6.2); 7.0415 (2.5); 7.0002 (0.5); 6.9972 (0.6); 4.9006 (2.7); 4.8619 (3.0); 4.7252 (0.9); 4.7167 (1.0); 4.6977 (1.8); 4.6892 (2.0); 4.6711 (1.0); 4.6622 (1.0); 4.2537 (3.3); 4.2144 (3.0); 3.9096 (0.5); 3.8986 (0.9); 3.8881 (1.4); 3.8769 (1.7); 3.8671 (1.6); 3.8576 (1.1); 3.8466 (0.6); 2.7503 (1.7); 2.7432 (1.8); 2.7407 (1.7); 2.7121 (2.1); 2.7048 (2.1); 2.6878 (0.4); 2.5606 (0.6); 2.5439 (0.8); 2.5186 (1.9); 2.4974 (1.7); 2.4771 (1.5); 2.4433 (1.1); 2.4280 (1.4); 2.4189 (1.6); 2.4037 (2.3); 2.3879 (2.5); 2.3852 (2.6); 2.3792 (1.4); 2.3642 (2.9); 2.3495 (1.8); 2.3468 (1.8); 2.3268 (1.6); 2.3240 (1.6); 2.3076 (0.6); 2.2900 (1.0); 2.2826 (0.7); 2.2738 (1.2); 2.2693 (1.0); 2.2657 (1.0); 2.2573 (1.4); 2.2496 (1.0); 2.2362 (1.0); 2.2335 (1.0); 2.2159 (0.5); 1.9461 (1.5); 1.9169 (1.6); 1.8478 (0.7); 1.8366 (1.2); 1.8243 (1.5); 1.8123 (2.0); 1.8040 (2.1); 1.7920 (2.4); 1.7792 (1.7); 1.6939 (3.0); 1.6616 (3.0); 1.5546 (28.1); 1.5526 (28.0); 1.5217 (0.5); 1.4822 (1.1); 1.4749 (1.1); 1.4678 (1.1); 1.3812 (0.9); 1.3515 (1.8); 1.3233 (1.1); 1.0874 (0.6); 1.0567 (1.5); 1.0302 (1.7); 1.0226 (1.4); 0.9976 (0.8); 0.9920 (0.7); 0.9810 (1.0); 0.9683 (0.6); 0.9510 (2.6); 0.9106 (14.7); 0.9022 (16.0); 0.8970 (15.2); 0.8944 (14.7); 0.8872 (12.8); 0.8848 (13.2); 0.8449 (1.4); 0.8152 (0.5); 0.7507 (12.5); 0.7333 (12.2); 0.0032 (42.7) I.1-105:1H NMR (400.0MHz, d6-DMSO): δ= 12.3773 (1.5); 7.3837 (3.2); 7.3797 (3.5); 7.3633 (6.9); 7.3591 (7.6); 7.3531 (4.0); 7.3434 (4.9); 7.3372 (7.6); 7.3332 (6.5); 7.3171 (4.0); 7.3130 (3.9); 7.2100 (4.2); 7.2060 (4.4); 7.1973 (4.4); 7.1933 (5.3); 7.1901 (8.0); 7.1863 (8.4); 7.1773 (7.7); 7.1738 (8.5); 7.1698 (5.2); 7.1658 (5.1); 7.1570 (4.5); 7.1533 (4.8); 7.0952 (8.3); 7.0792 (11.0); 7.0598 (5.5); 4.7425 (12.4); 4.7031 (14.4); 4.2541 (16.0); 4.2145 (13.8); 3.7884 (2.7); 3.7780 (5.1); 3.7672 (7.1); 3.7579 (7.7); 3.7473 (6.9); 3.7367 (5.4); 3.7262 (2.2); 3.6385 (0.9); 3.3168 (89.6); 3.1651 (0.6); 2.7041 (12.6); 2.6939 (12.6); 2.6793 (1.6); 2.6747 (3.0); 2.6701 (4.8); 2.6644 (17.6); 2.6541 (15.4); 2.5618 (1.4); 2.5573 (1.7); 2.5528 (1.2); 2.5403 (1.6); 2.5236 (9.4); 2.5189 (14.8); 2.5102 (203.5); 2.5056 (437.7); 2.5010 (608.9); 2.4964 (428.8); 2.4919 (192.2); 2.4614 (2.0); 2.4563 (2.4); 2.4518 (2.2); 2.4469 (3.4); 2.4290 (4.0); 2.4192 (2.3); 2.4052 (10.4); 2.3986 (17.6); 2.3877 (7.9); 2.3805 (8.1); 2.3766 (17.3); 2.3650 (4.4); 2.3588 (13.7); 2.3498 (2.1); 2.3368 (14.3); 2.3279 (4.2); 2.3232 (2.8); 2.2887 (6.0); 2.2757 (6.7); 2.2642 (11.0); 2.2513 (10.8); 2.2363 (1.0); 2.2229 (9.2); 2.2199 (9.6); 2.2115 (6.8); 2.2059 (6.6); 2.1956 (5.9); 2.1900 (4.7); 2.1777 (7.1); 2.1712 (3.6); 2.1656 (2.7); 2.1584 (4.6); 2.1524 (4.1); 2.1340 (2.4); 2.0733 (1.0); 1.7823 (1.1); 1.7603 (3.1); 1.7547 (6.9); 1.7436 (7.0); 1.7307 (7.3); 1.7255 (4.2); 1.7198 (3.9); 1.7140 (4.9); 1.7008 (4.4); 1.6883 (2.8); 0.1461 (1.0); 0.0512 (0.6); 0.0080 (9.4); 0.0062 (3.6); -0.0002 (315.7); -0.0060 (4.4); -0.0069 (3.9); -0.0085 (9.8); - 0.0500 (1.2); -0.1495 (1.0) I.1-106:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4043 (1.2); 7.1443 (1.7); 7.1240 (7.7); 7.1120 (8.4); 7.0913 (1.8); 4.6741 (2.0); 4.6359 (2.2); 3.9988 (2.2); 3.9607 (2.0); 3.8465 (1.8); 3.8401 (2.1); 3.8362 (2.2); 3.8326 (2.4); 3.8300 (2.4); 3.8266 (2.2); 3.8227 (2.1); 3.8163 (1.8); 3.7181 (0.7); 3.7071 (1.0); 3.6970 (1.1); 3.6871 (0.9); 3.6760 (0.7); 3.3125 (77.6); 3.2621 (0.6); 3.1680 (0.8); 3.1079 (1.6); 3.1016 (3.0); 3.0958 (1.4); 2.6694 (0.7); 2.5298 (1.6); 2.5228 (1.8); 2.5182 (3.7); 2.5095 (40.9); 2.5049 (87.8); 2.5003 (121.6); 2.4957 (86.2); 2.4912 (38.5); 2.4505 (0.6); 2.3737 (0.6); 2.3517 (1.2); 2.3318 (1.6); 2.3274 (1.5); 2.3093 (0.9); 2.2763 (16.0); 2.2649 (1.2); 2.2512 (1.2); 2.2402 (1.3); 2.2270 (1.3); 2.2093 (0.6); 2.1985 (0.7); 2.1853 (0.7); 2.1613 (1.7); 2.1392 (1.7); 2.1264 (1.5); 2.1042 (1.4); 2.0717 (0.9); 2.0514 (0.8); 2.0389 (0.6); 2.0272 (0.8); 2.0196 (1.0); 1.9956 (0.8); 1.6979 (0.6); 1.6869 (0.9); 1.6767 (0.7); 1.6645 (0.7); 1.6550 (0.7); 0.0080 (0.8); - 0.0002 (27.1); -0.0086 (0.8) I.1-107:1H NMR (400.0MHz, d6-DMSO): δ= 7.4636 (0.6); 7.4548 (5.6); 7.4497 (1.8); 7.4378 (1.8); 7.4324 (6.3); 7.4238 (0.6); 7.1292 (2.0); 7.1086 (7.5); 7.0949 (8.0); 7.0744 (2.0); 6.9234 (0.7); 6.9147 (6.0); 6.9094 (1.9); 6.8976 (1.8); 6.8923 (5.7); 4.6476 (2.0); 4.6095 (2.3); 4.3213 (1.2); 4.3111 (3.2); 4.3015 (3.1); 4.2919 (1.6); 4.1467 (3.1); 4.1354 (4.5); 4.1244 (2.4); 4.0468 (2.3); 4.0085 (2.1); 3.7205 (0.7); 3.7102 (1.1); 3.6996 (1.2); 3.6895 (1.0); 3.6791 (0.8); 3.3486 (75.3); 2.7789 (1.3); 2.7688 (1.3); 2.7391 (1.7); 2.7290 (1.6); 2.5055 (56.9); 2.5011 (78.0); 2.4967 (56.5); 2.4758 (2.0); 2.4540 (1.8); 2.4360 (1.5); 2.4141 (1.7); 2.4048 (0.6); 2.3871 (1.2); 2.3691 (0.9); 2.3631 (0.9); 2.3455 (0.8); 2.2632 (16.0); 2.2471 (1.3); 2.2332 (1.2); 2.2053 (0.7); 2.1920 (0.7); 2.1307 (0.7); 2.1182 (0.6); 2.1123 (0.5); 2.1056 (0.6); 2.0995 (0.9); 2.0744 (0.6); 1.7090 (0.7); 1.6975 (0.8); 1.6869 (0.7); 1.6768 (0.7); 1.6654 (0.7); 1.6532 (0.5); -0.0002 (3.4) I.1-108:1H NMR (400.1 MHz, d6-DMSO): δ= 19.7654 (0.7); 19.7059 (0.7); 17.6711 (0.8); 17.1313 (0.7); 14.0023 (0.7); 12.6881 (0.7); 11.6932 (0.8); 8.3710 (7.3); 8.3494 (7.0); 7.4486 (0.7); 7.3835 (2.1); 7.3638 (4.8); 7.3410 (4.7); 7.3190 (2.7); 7.2892 (0.8); 7.2104 (2.6); 7.1910 (5.5); 7.1789 (6.0); 7.1607 (5.7); 7.1546 (6.4); 7.1441 (8.4); 7.1390 (12.3); 7.1300 (12.0); 7.1250 (11.6); 7.1018 (15.0); 7.0957 (16.0); 7.0781 (12.2); 7.0590 (3.6); 6.6020 (0.7); 4.9535 (3.4); 4.9384 (4.4); 4.7582 (7.4); 4.7184 (8.7); 4.2744 (4.6); 4.2540 (5.1); 4.2354 (4.1); 4.2140 (4.2); 3.8711 (1.9); 3.8605 (2.8); 3.8499 (3.7); 3.8371 (3.8); 3.8264 (3.4); 3.8173 (3.0); 3.8057 (1.6); 3.5814 (0.7); 3.5223 (0.7); 3.4939 (0.8); 3.4290 (1.7); 3.3282 (392.0); 3.2339 (1.8); 3.2191 (1.6); 3.1935 (1.2); 3.1687 (10.9); 2.8908 (2.3); 2.7728 (1.8); 2.7438 (3.8); 2.7307 (7.0); 2.7181 (6.0); 2.7034 (6.3); 2.6704 (6.4); 2.6468 (1.5); 2.6102 (0.9); 2.5963 (1.2); 2.5828 (3.6); 2.5732 (5.3); 2.5653 (5.2); 2.5497 (7.2); 2.5408 (10.4); 2.5061 (759.5); 2.5017 (1025.9); 2.4973 (785.6); 2.4215 (3.1); 2.3994 (3.1); 2.3813 (3.8); 2.3736 (4.1); 2.3555 (4.9); 2.3290 (7.1); 2.3245 (5.5); 2.3106 (2.9); 2.2989 (3.8); 2.2867 (5.8); 2.2815 (5.9); 2.2704 (6.1); 2.2609 (6.3); 2.2476 (7.6); 2.2348 (5.5); 2.2263 (4.3); 2.2145 (4.0); 2.1923 (2.1); 2.1687 (2.4); 2.1575 (3.1); 2.1395 (3.1); 2.1243 (2.4); 2.1006 (1.8); 2.0718 (3.2); 2.0201 (0.7); 1.9080 (0.7); 1.8353 (8.2); 1.8253 (9.3); 1.8157 (9.2); 1.7441 (1.9); 1.7206 (3.0); 1.7063 (4.1); 1.6799 (3.3); 1.6650 (3.2); 1.6491 (3.1); 1.6271 (3.9); 1.6062 (2.9); 0.1451 (0.8); 0.0082 (5.3) I.1-109:1H NMR (400.1 MHz, CDCl3): δ= 7.2620 (55.2); 7.2122 (0.6); 7.1295 (0.4); 7.1162 (0.8); 7.1047 (1.5); 7.0951 (0.9); 7.0869 (1.6); 7.0803 (1.6); 7.0760 (1.1); 7.0621 (6.5); 7.0523 (6.0); 7.0443 (2.1); 7.0383 (1.7); 4.9128 (1.9); 4.9094 (2.0); 4.9008 (0.5); 4.8741 (2.2); 4.8705 (2.2); 4.8622 (0.6); 4.8585 (0.5); 4.7174 (1.0); 4.7065 (1.0); 4.6968 (0.5); 4.6902 (2.0); 4.6793 (2.0); 4.6630 (1.1); 4.6520 (1.0); 4.2507 (0.7); 4.2430 (3.0); 4.2042 (2.7); 3.8924 (0.5); 3.8821 (0.9); 3.8716 (1.3); 3.8612 (1.4); 3.8499 (1.2); 3.8395 (0.9); 3.8293 (0.5); 2.7500 (0.4); 2.7401 (0.5); 2.7321 (2.0); 2.7227 (2.0); 2.7117 (0.5); 2.7016 (0.6); 2.6944 (2.6); 2.6850 (2.5); 2.5609 (0.6); 2.5425 (0.7); 2.5367 (0.7); 2.5180 (1.8); 2.4996 (1.4); 2.4940 (1.4); 2.4757 (1.4); 2.4378 (1.2); 2.4237 (1.4); 2.4183 (0.6); 2.4132 (1.7); 2.4018 (3.3); 2.3845 (0.8); 2.3794 (2.9); 2.3702 (1.1); 2.3642 (2.4); 2.3564 (1.0); 2.3465 (0.6); 2.3416 (2.1); 2.3239 (0.4); 2.2938 (0.7); 2.2746 (1.2); 2.2696 (0.7); 2.2614 (0.9); 2.2557 (0.8); 2.2499 (0.9); 2.2421 (1.2); 2.2368 (0.9); 2.2311 (0.6); 2.2229 (0.7); 2.2173 (0.9); 2.1985 (0.5); 1.9647 (0.5); 1.9530 (1.1); 1.9456 (0.9); 1.9349 (0.7); 1.9301 (0.8); 1.9228 (1.2); 1.9005 (0.7); 1.8872 (0.8); 1.8759 (1.2); 1.8655 (0.9); 1.8538 (0.9); 1.8431 (1.1); 1.8324 (0.8); 1.8240 (0.6); 1.8182 (0.9); 1.8073 (1.0); 1.8005 (1.1); 1.7896 (1.4); 1.7831 (1.3); 1.7722 (1.0); 1.7653 (1.0); 1.7547 (0.4); 1.7484 (0.4); 1.6921 (2.3); 1.6850 (1.9); 1.6660 (2.3); 1.6597 (2.4); 1.6516 (1.6); 1.6446 (0.6); 1.5676 (16.8); 1.5181 (0.4); 1.5113 (0.4); 1.5033 (0.5); 1.4953 (0.6); 1.4896 (0.7); 1.4816 (0.8); 1.4737 (0.8); 1.4654 (0.9); 1.4572 (0.7); 1.4510 (0.6); 1.4438 (0.6); 1.4357 (0.5); 1.3961 (0.5); 1.3883 (0.8); 1.3810 (0.6); 1.3583 (1.4); 1.3384 (0.6); 1.3303 (1.0); 1.3228 (0.7); 1.0850 (0.6); 1.0596 (1.1); 1.0531 (1.3); 1.0284 (1.6); 1.0206 (1.2); 0.9958 (1.6); 0.9893 (0.6); 0.9785 (0.3); 0.9657 (2.4); 0.9488 (0.6); 0.9376 (2.2); 0.9101 (16.0); 0.8988 (15.3); 0.8938 (15.8); 0.8814 (14.5); 0.8607 (0.4); 0.8484 (1.1); 0.8441 (1.1); 0.8186 (0.4); 0.7478 (13.9); 0.7304 (13.5); 0.0082 (0.7); 0.0000 (23.9) I.1-111:1H NMR (400.0MHz, d6-DMSO): δ= 7.9089 (0.8); 7.1441 (1.6); 7.1238 (6.1); 7.1098 (6.6); 7.0892 (1.6); 4.6676 (1.6); 4.6296 (1.8); 4.0134 (1.9); 3.9756 (1.6); 3.7175 (0.6); 3.7065 (0.8); 3.6961 (0.9); 3.6863 (0.8); 3.6753 (0.6); 3.4499 (16.0); 3.0047 (0.7); 2.9942 (0.8); 2.9870 (1.5); 2.9768 (1.5); 2.9727 (1.5); 2.9628 (1.4); 2.9551 (0.7); 2.9455 (0.7); 2.5231 (0.7); 2.5184 (1.0); 2.5098 (15.6); 2.5052 (33.6); 2.5006 (47.3); 2.4960 (32.7); 2.4915 (14.9); 2.4650 (1.4); 2.4539 (1.4); 2.3429 (0.9); 2.3233 (1.0); 2.3010 (0.8); 2.2756 (13.0); 2.2670 (1.2); 2.2529 (1.0); 2.2425 (1.1); 2.2287 (1.0); 2.2007 (0.6); 2.1870 (0.5); 2.1187 (1.4); 2.0962 (1.3); 2.0843 (1.2); 2.0618 (1.2); 2.0463 (0.6); 2.0222 (0.6); 2.0147 (0.8); 1.9905 (0.6); 1.6966 (0.7); 1.6865 (0.6); 1.6748 (0.5); 1.6646 (0.6); 1.4013 (1.5); 1.3832 (3.0); 1.3651 (3.3); 1.3471 (1.7); 0.8387 (5.4); 0.8203 (11.1); 0.8017 (4.7) I.1-112:1H NMR (400.0 MHz, i.e6-DMSO): δ= 10.8315 (1.3); 8.3271 (0.8); 8.3077 (1.5); 8.2885 (0.9); 7.5321 (0.9); 7.5210 (1.0); 7.5131 (1.0); 7.5019 (1.1); 7.3409 (0.9); 7.3286 (2.6); 7.3084 (3.1); 7.1670 (0.7); 7.1516 (0.8); 7.1346 (0.8); 7.1158 (2.7); 7.0659 (0.7); 7.0628 (0.7); 7.0482 (1.5); 7.0334 (1.2); 7.0303 (1.0); 7.0253 (0.8); 6.9860 (1.3); 6.9836 (1.4); 6.9666 (2.0); 6.9495 (1.6); 6.9326 (0.6); 6.9300 (0.6); 4.7106 (0.6); 4.6801 (0.8); 4.6716 (0.8); 4.6404 (0.8); 4.5032 (0.7); 4.4909 (0.7); 4.4827 (0.8); 4.4703 (0.7); 4.1974 (0.8); 4.1574 (0.7); 4.1352 (0.9); 4.0958 (0.8); 3.6900 (0.5); 3.6808 (0.7); 3.6703 (0.8); 3.6601 (0.8); 3.6508 (0.6); 3.4760 (16.0); 3.1850 (0.6); 3.1738 (0.6); 3.1679 (0.7); 3.1491 (0.9); 3.1384 (0.8); 3.0043 (1.1); 2.9815 (1.1); 2.9679 (0.8); 2.9455 (0.8); 2.6701 (0.6); 2.5341 (0.7); 2.5237 (1.5); 2.5189 (2.5); 2.5103 (33.0); 2.5057 (71.6); 2.5011 (99.7); 2.4965 (69.4); 2.4919 (31.1); 2.4730 (0.8); 2.3278 (0.6); 2.2630 (0.6); 2.2436 (0.9); 2.2244 (0.5); 2.2103 (0.7); 2.1970 (0.7); 2.1878 (1.3); 2.1754 (1.9); 2.1636 (1.4); 2.1518 (1.3); 2.1406 (0.6); 2.0727 (0.5); -0.0002 (5.4) I.1-113:1H NMR (400.0MHz, d6-DMSO): δ= 16.6531 (1.0); 16.4917 (1.2); 10.8380 (7.6); 8.3084 (7.5); 8.2888 (7.4); 7.5218 (8.8); 7.5025 (9.6); 7.3612 (2.6); 7.3371 (5.5); 7.3285 (13.2); 7.3083 (15.1); 7.2952 (2.2); 7.1709 (3.0); 7.1473 (4.9); 7.1350 (5.2); 7.1264 (3.7); 7.1167 (16.0); 7.1112 (12.4); 7.0658 (5.2); 7.0456 (9.4); 7.0281 (6.7); 7.0010 (4.2); 6.9845 (6.2); 6.9696 (9.2); 6.9671 (10.0); 6.9498 (11.2); 6.9324 (5.1); 6.9301 (4.5); 4.6804 (6.9); 4.6414 (7.6); 4.5027 (2.9); 4.4907 (3.8); 4.4816 (4.3); 4.4703 (4.2); 4.4612 (3.1); 4.4480 (2.3); 4.1353 (7.8); 4.0954 (7.4); 3.6820 (3.4); 3.6711 (4.3); 3.6609 (4.4); 3.6489 (3.8); 3.6396 (3.4); 3.4468 (130.7); 3.4028 (10.7); 3.3984 (10.2); 3.3937 (10.1); 3.3891 (9.3); 3.3843 (7.9); 3.3794 (5.9); 3.3739 (4.2); 3.3683 (3.6); 3.3634 (3.4); 3.3583 (3.8); 3.3542 (3.6); 3.3498 (3.4); 3.3244 (4.1); 3.3127 (2.1); 3.3078 (1.2); 3.3004 (1.2); 3.2956 (2.7); 3.2906 (3.3); 3.2855 (2.8); 3.2799 (2.2); 3.2338 (2.1); 3.2291 (2.1); 3.2236 (2.1); 3.2187 (2.8); 3.2143 (4.8); 3.2076 (3.4); 3.1850 (4.2); 3.1722 (5.5); 3.1678 (7.6); 3.1475 (6.0); 3.1365 (5.6); 3.1015 (1.3); 3.0458 (1.3); 3.0411 (1.4); 3.0048 (5.7); 2.9815 (5.6); 2.9676 (5.3); 2.9456 (4.1); 2.6705 (3.7); 2.6655 (2.5); 2.6364 (1.1); 2.5478 (1.9); 2.5103 (226.6); 2.5058 (476.1); 2.5012 (643.3); 2.4966 (445.4); 2.4920 (197.1); 2.4729 (9.5); 2.4609 (5.4); 2.4563 (7.0); 2.4518 (7.8); 2.4470 (5.2); 2.4426 (2.8); 2.4060 (1.9); 2.3817 (1.7); 2.3280 (3.9); 2.3233 (3.0); 2.3039 (2.5); 2.2817 (3.4); 2.2621 (4.9); 2.2411 (5.5); 2.2188 (4.4); 2.2100 (6.2); 2.1877 (9.8); 2.1757 (9.4); 2.1639 (5.8); 2.1523 (8.2); 2.1326 (2.3); 2.1217 (3.2); 2.1100 (2.3); 2.0729 (2.2); 2.0162 (1.3); 1.9686 (1.5); 1.9483 (3.3); 1.9348 (2.8); 1.9243 (2.8); 1.9158 (4.2); 1.8909 (3.6); 1.8859 (2.2); 1.8811 (1.8); 1.8721 (2.0); 1.8575 (1.2); 1.8273 (1.2); 1.8158 (1.2); 1.7611 (2.1); 1.7379 (1.4); 1.7304 (1.3); 1.7086 (3.0); 1.7038 (3.0); 1.6981 (3.3); 1.6875 (1.9); 1.6635 (5.3); 1.6538 (2.8); 1.6417 (2.7); 1.6305 (2.2); 1.6066 (2.5); 1.6019 (2.6); 1.5973 (2.6); 1.4791 (1.1); -0.0002 (19.8) I.1-114:1H NMR (400.0 MHz, i.e6-DMSO): δ= 11.8093 (5.6); 7.5295 (2.0); 7.5212 (2.0); 7.5135 (3.2); 7.5050 (2.9); 7.5030 (3.0); 7.4960 (1.7); 7.4873 (2.2); 7.2311 (1.2); 7.2266 (1.1); 7.2153 (11.8); 7.2119 (6.5); 7.2060 (5.7); 7.1994 (7.2); 7.1964 (10.7); 7.1857 (0.6); 7.1800 (0.7); 7.0726 (2.1); 6.9448 (2.0); 4.7058 (3.8); 4.6662 (4.4); 4.2413 (4.7); 4.2012 (4.0); 3.9643 (4.0); 3.8630 (0.7); 3.8528 (1.5); 3.8422 (2.1); 3.8322 (2.4); 3.8220 (2.0); 3.8116 (1.5); 3.8020 (0.7); 3.3888 (70.2); 3.2101 (64.7); 3.1681 (16.0); 2.7502 (3.2); 2.7397 (3.2); 2.7120 (4.0); 2.7015 (3.8); 2.6788 (0.8); 2.6742 (1.6); 2.6695 (2.4); 2.6650 (1.6); 2.6602 (0.8); 2.5554 (0.5); 2.5507 (0.8); 2.5460 (0.8); 2.5398 (1.5); 2.5231 (6.2); 2.5183 (9.1); 2.5097 (130.5); 2.5052 (276.0); 2.5005 (376.9); 2.4959 (262.8); 2.4913 (118.3); 2.4408 (4.5); 2.4188 (4.7); 2.4022 (4.7); 2.3807 (5.7); 2.3597 (1.6); 2.3365 (0.9); 2.3319 (1.7); 2.3273 (2.3); 2.3227 (1.6); 2.3180 (0.8); 2.3083 (1.7); 2.2960 (2.0); 2.2842 (2.9); 2.2721 (2.8); 2.2553 (0.6); 2.2426 (1.9); 2.2319 (3.0); 2.2145 (2.2); 2.2028 (1.5); 2.1956 (1.2); 2.1904 (1.2); 2.1836 (2.3); 2.1715 (0.7); 2.1638 (1.3); 2.1593 (1.5); 2.1400 (0.6); 2.0719 (1.0); 1.7926 (0.8); 1.7841 (1.7); 1.7728 (1.6); 1.7622 (1.8); 1.7544 (1.9); 1.7423 (1.4); 1.7295 (1.2); 1.7181 (0.8); 0.0120 (0.6); 0.0080 (1.3); -0.0002 (46.8); -0.0085 (1.3) I.1-115:1H NMR (400.1 MHz, d6-DMSO): δ= 12.3254 (1.7); 7.2129 (1.0); 7.2059 (1.9); 7.1962 (12.0); 7.1791 (12.6); 7.1742 (12.5); 7.1639 (3.2); 7.1573 (11.6); 7.1476 (2.0); 7.1404 (1.0); 4.5857 (8.6); 4.5461 (10.4); 4.2417 (0.3); 4.1978 (11.6); 4.1583 (9.7); 3.9660 (0.8); 3.8065 (1.9); 3.7955 (3.4); 3.7847 (5.0); 3.7753 (5.5); 3.7649 (5.0); 3.7544 (3.9); 3.7433 (1.8); 3.5809 (0.4); 3.5573 (0.5); 3.3351 (12.0); 3.1710 (16.0); 2.6799 (8.9); 2.6695 (9.2); 2.6399 (11.2); 2.6295 (10.9); 2.5248 (0.8); 2.5201 (1.2); 2.5114 (25.4); 2.5068 (56.9); 2.5022 (80.2); 2.4976 (57.3); 2.4930 (26.5); 2.4431 (2.2); 2.4260 (2.7); 2.4174 (2.3); 2.4018 (6.5); 2.3845 (5.3); 2.3778 (5.2); 2.3714 (12.2); 2.3625 (4.5); 2.3496 (11.3); 2.3315 (9.8); 2.3254 (5.4); 2.3098 (12.1); 2.3011 (7.8); 2.2871 (7.6); 2.2706 (0.9); 2.2597 (4.4); 2.2474 (7.5); 2.2323 (3.4); 2.2301 (4.0); 2.2230 (1.5); 2.2189 (3.8); 2.2134 (3.0); 2.2086 (2.1); 2.2057 (2.5); 2.2015 (4.4); 2.1947 (2.8); 2.1893 (1.9); 2.1820 (3.1); 2.1754 (2.8); 2.1577 (1.7); 1.7551 (2.2); 1.7447 (4.1); 1.7332 (4.5); 1.7267 (2.9); 1.7223 (3.7); 1.7154 (4.8); 1.7084 (2.8); 1.7022 (4.3); 1.6907 (2.9); 1.6769 (1.9); 0.0082 (0.5); 0.0000 (16.4) I.1-116:1H NMR (400.0MHz, d6-DMSO): δ= 7.1474 (1.7); 7.1294 (2.0); 7.1162 (6.1); 7.1099 (8.8); 7.0968 (11.4); 7.0768 (1.8); 6.8372 (5.8); 6.8156 (4.9); 4.6496 (2.1); 4.6111 (2.2); 4.3323 (0.5); 4.3134 (1.3); 4.3022 (3.4); 4.2907 (3.8); 4.2803 (1.4); 4.1070 (3.1); 4.0961 (5.0); 4.0844 (2.4); 4.0504 (2.4); 4.0124 (2.0); 3.7272 (0.7); 3.7168 (1.1); 3.7061 (1.2); 3.6952 (1.1); 3.6844 (0.7); 3.3485 (2.7); 3.3230 (697.4); 3.2993 (40.8); 3.2006 (0.8); 3.1749 (0.5); 2.7825 (1.3); 2.7724 (1.4); 2.7426 (1.7); 2.7324 (1.8); 2.6703 (1.4); 2.5566 (1.4); 2.5376 (4.8); 2.5100 (89.9); 2.5057 (185.1); 2.5012 (250.3); 2.4968 (175.9); 2.4755 (2.2); 2.4535 (2.0); 2.4353 (1.9); 2.4140 (2.0); 2.3891 (1.4); 2.3718 (1.1); 2.3482 (1.0); 2.3280 (1.6); 2.2817 (1.3); 2.2633 (16.0); 2.2460 (1.3); 2.2318 (1.3); 2.2146 (0.5); 2.2041 (0.8); 2.1906 (0.8); 2.1522 (0.6); 2.1325 (0.7); 2.1206 (0.7); 2.1023 (1.0); 2.0732 (0.8); 1.7145 (0.7); 1.7035 (0.8); 1.6922 (0.8); 1.6714 (0.8); 1.6600 (0.5); 1.1683 (0.8); 1.1563 (6.1); 1.1373 (13.1); 1.1183 (5.9); -0.0002 (13.3) I.1-117:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.3045 (2.6); 7.2993 (1.0); 7.2858 (4.0); 7.2829 (3.9); 7.2644 (3.3); 7.1313 (1.9); 7.1106 (7.7); 7.0983 (8.2); 7.0777 (1.8); 6.9612 (1.5); 6.9429 (2.7); 6.9279 (4.8); 6.9085 (4.1); 4.6502 (2.0); 4.6120 (2.2); 4.3313 (1.3); 4.3203 (3.7); 4.3089 (4.0); 4.2986 (1.5); 4.1439 (3.3); 4.1326 (5.3); 4.1211 (2.4); 4.0531 (2.3); 4.0150 (2.0); 3.7295 (0.7); 3.7186 (1.1); 3.7083 (1.2); 3.6983 (1.1); 3.6875 (0.7); 3.3626 (76.8); 2.7840 (1.3); 2.7738 (1.4); 2.7443 (1.8); 2.7340 (1.7); 2.5234 (1.1); 2.5100 (25.0); 2.5056 (52.1); 2.5011 (71.0); 2.4967 (50.4); 2.4923 (23.2); 2.4805 (2.2); 2.4587 (1.8); 2.4407 (1.5); 2.4330 (0.6); 2.4189 (1.7); 2.4072 (0.8); 2.3908 (1.2); 2.3728 (0.9); 2.3669 (0.8); 2.3493 (0.8); 2.2632 (16.0); 2.2475 (1.3); 2.2337 (1.2); 2.2056 (0.8); 2.1925 (0.8); 2.1371 (0.7); 2.1243 (0.6); 2.1188 (0.5); 2.1124 (0.6); 2.1056 (0.9); 2.0863 (0.5); 2.0810 (0.6); 1.7191 (0.7); 1.7073 (0.9); 1.6964 (0.7); 1.6871 (0.7); 1.6754 (0.8); 1.6635 (0.5) I.1-118:1H NMR (400.0MHz, d6-DMSO): δ= 7.3718 (1.6); 7.3679 (1.7); 7.3514 (3.5); 7.3476 (3.8); 7.3415 (2.0); 7.3316 (2.4); 7.3257 (3.9); 7.3050 (2.0); 7.3016 (1.9); 7.2046 (2.2); 7.2008 (2.3); 7.1919 (2.3); 7.1848 (4.1); 7.1810 (4.3); 7.1721 (4.0); 7.1685 (4.3); 7.1645 (2.6); 7.1605 (2.5); 7.1516 (2.2); 7.1482 (2.3); 7.0849 (4.2); 7.0690 (5.7); 7.0496 (2.8); 4.7002 (6.5); 4.6608 (7.8); 4.2973 (8.4); 4.2575 (7.0); 3.9112 (1.3); 3.8999 (2.5); 3.8912 (3.3); 3.8802 (4.7); 3.8711 (2.9); 3.8606 (2.5); 3.8492 (1.1); 3.4027 (98.0); 3.3419 (2.7); 3.3248 (4.7); 3.3164 (3.7); 3.3078 (3.4); 3.2998 (6.0); 3.2827 (3.4); 3.2515 (1.1); 3.2345 (2.0); 3.2221 (4.4); 3.2047 (13.6); 3.1875 (16.0); 3.1778 (3.8); 3.1703 (7.4); 3.1613 (5.2); 3.1444 (2.8); 2.6709 (5.0); 2.6594 (4.5); 2.6309 (5.8); 2.6190 (5.5); 2.5234 (3.1); 2.5187 (4.6); 2.5101 (70.3); 2.5055 (151.7); 2.5009 (210.5); 2.4963 (146.2); 2.4917 (65.3); 2.4619 (2.2); 2.4441 (2.5); 2.4354 (1.9); 2.4204 (5.1); 2.4040 (8.7); 2.3975 (4.0); 2.3841 (7.5); 2.3642 (4.8); 2.3438 (4.6); 2.3323 (1.0); 2.3277 (1.4); 2.3231 (1.0); 2.2797 (3.1); 2.2669 (3.4); 2.2555 (5.3); 2.2426 (5.3); 2.2269 (0.7); 2.2142 (4.1); 2.2071 (6.0); 2.1924 (3.2); 2.1811 (2.8); 2.1753 (2.3); 2.1629 (4.0); 2.1571 (1.9); 2.1511 (1.3); 2.1438 (2.3); 2.1385 (2.4); 2.1193 (1.2); 2.0717 (0.9); 1.8589 (0.6); 1.8458 (1.3); 1.8289 (3.7); 1.8174 (4.6); 1.8111 (5.8); 1.8009 (6.6); 1.7936 (4.8); 1.7848 (5.2); 1.7766 (2.6); 1.7690 (2.6); 1.7617 (1.4); 1.7479 (2.8); 1.7383 (2.7); 1.7319 (5.9); 1.7209 (8.6); 1.7177 (7.8); 1.7097 (5.3); 1.7003 (8.8); 1.6915 (4.0); 1.6861 (5.8); 1.6796 (3.4); 1.6677 (3.1); 1.6548 (2.0); -0.0002 (1.6) I.1-119:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1315 (1.8); 7.1110 (7.6); 7.0986 (8.1); 7.0865 (4.2); 7.0655 (4.5); 6.8231 (0.8); 6.8158 (5.6); 6.7945 (4.7); 4.6509 (2.0); 4.6127 (2.2); 4.3104 (1.2); 4.2996 (3.4); 4.2883 (3.6); 4.2781 (1.4); 4.0993 (3.1); 4.0881 (4.9); 4.0765 (2.4); 4.0507 (2.3); 4.0125 (2.0); 3.7260 (0.7); 3.7156 (1.0); 3.7052 (1.2); 3.6949 (1.1); 3.6847 (0.8); 3.5245 (4.6); 2.7822 (1.3); 2.7720 (1.3); 2.7424 (1.7); 2.7323 (1.6); 2.5101 (9.4); 2.5059 (19.2); 2.5015 (25.7); 2.4971 (18.2); 2.4759 (1.8); 2.4541 (1.7); 2.4361 (1.5); 2.4143 (1.8); 2.4077 (0.6); 2.3898 (1.1); 2.3718 (0.9); 2.3660 (0.8); 2.3482 (0.8); 2.2648 (15.6); 2.2463 (1.3); 2.2245 (16.0); 2.2046 (0.8); 2.1913 (0.8); 2.1336 (0.7); 2.1208 (0.6); 2.1150 (0.5); 2.1086 (0.6); 2.1024 (0.9); 2.0965 (0.5); 2.0829 (0.5); 2.0774 (0.6); 1.7149 (0.6); 1.7030 (0.8); 1.6919 (0.7); 1.6830 (0.7); 1.6711 (0.7); - 0.0002 (0.6) I.1-120:1H NMR (400.1 MHz, d6-DMSO): δ= 11.7028 (3.9); 7.3857 (0.5); 7.3819 (0.6); 7.3615 (1.4); 7.3394 (1.4); 7.3190 (0.7); 7.3154 (0.7); 7.2125 (0.6); 7.2092 (0.7); 7.1926 (1.4); 7.1892 (1.5); 7.1770 (1.5); 7.1690 (0.9); 7.1595 (0.8); 7.1564 (0.8); 7.0754 (1.4); 7.0590 (2.0); 7.0403 (1.0); 4.7263 (2.3); 4.6864 (2.7); 4.2446 (2.8); 4.2045 (2.4); 3.8459 (0.4); 3.8360 (0.9); 3.8252 (1.3); 3.8151 (1.5); 3.8046 (1.3); 3.7948 (1.0); 3.7849 (0.5); 3.3584 (3.1); 3.3400 (10.5); 3.3219 (14.3); 3.3036 (4.2); 3.1691 (10.1); 2.7798 (1.8); 2.7697 (1.8); 2.7415 (2.2); 2.7313 (2.2); 2.5231 (0.4); 2.5098 (14.4); 2.5054 (31.9); 2.5009 (45.4); 2.4964 (33.9); 2.4919 (16.8); 2.4584 (2.4); 2.4364 (2.4); 2.4203 (2.4); 2.3983 (3.2); 2.3797 (1.5); 2.3584 (1.1); 2.3278 (0.3); 2.3045 (1.0); 2.2919 (1.2); 2.2802 (1.6); 2.2677 (1.6); 2.2511 (0.4); 2.2385 (1.0); 2.2276 (1.2); 2.2229 (1.0); 2.2046 (1.2); 2.1928 (0.8); 2.1857 (0.7); 2.1805 (0.8); 2.1736 (1.3); 2.1616 (0.5); 2.1539 (0.8); 2.1495 (0.9); 2.1299 (0.4); 1.7782 (0.5); 1.7684 (1.0); 1.7570 (1.0); 1.7463 (1.1); 1.7383 (1.2); 1.7259 (0.9); 1.7143 (0.7); 1.7023 (0.4); 1.2086 (7.2); 1.1903 (16.0); 1.1719 (7.1); 0.0083 (0.3) I.1-121:1H NMR (400.0MHz, d6-DMSO): δ= 12.5493 (1.1); 8.2765 (1.5); 8.2561 (1.6); 7.1739 (2.6); 7.1532 (7.5); 7.1340 (6.9); 7.1133 (2.1); 4.6775 (1.7); 4.6395 (1.9); 4.2451 (0.6); 4.2300 (0.8); 4.2106 (0.9); 4.0522 (1.8); 4.0139 (1.8); 3.7059 (1.1); 3.6965 (0.9); 3.6864 (0.7); 3.3642 (0.7); 3.3248 (153.5); 3.2909 (1.5); 3.1858 (1.3); 3.1672 (2.3); 2.8282 (0.6); 2.7570 (1.3); 2.6744 (2.9); 2.6697 (4.0); 2.6652 (2.9); 2.6057 (1.6); 2.5869 (4.0); 2.5680 (4.3); 2.5490 (1.5); 2.5231 (9.7); 2.5185 (15.2); 2.5098 (232.1); 2.5052 (507.3); 2.5006 (711.3); 2.4960 (503.2); 2.4915 (227.5); 2.4716 (5.0); 2.4670 (5.4); 2.4624 (4.1); 2.3708 (0.9); 2.3495 (1.3); 2.3320 (3.8); 2.3275 (5.2); 2.3229 (3.5); 2.3067 (1.1); 2.2713 (1.0); 2.2568 (1.1); 2.2464 (1.2); 2.2280 (1.9); 2.2053 (1.8); 2.1938 (1.5); 2.1716 (1.2); 2.0733 (1.1); 2.0078 (0.8); 1.9830 (0.7); 1.7128 (0.8); 1.6020 (0.8); 1.5881 (0.7); 1.5121 (1.2); 1.5000 (1.6); 1.4868 (1.8); 1.4655 (1.0); 1.1933 (0.9); 1.1841 (7.1); 1.1753 (1.9); 1.1652 (16.0); 1.1462 (6.9); 1.0966 (0.6); 1.0782 (1.0); 1.0601 (0.5); 0.9820 (0.6); 0.8917 (8.1); 0.8753 (7.9); 0.8255 (8.0); 0.8093 (7.7); 0.1462 (1.0); 0.0080 (9.7); -0.0002 (346.4); -0.0086 (10.6); -0.0338 (2.0); -0.1494 (1.2) I.1-122:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.3683 (0.6); 7.3479 (1.4); 7.3258 (1.4); 7.3056 (0.6); 7.2030 (0.8); 7.1872 (1.5); 7.1832 (1.5); 7.1708 (1.6); 7.1626 (1.0); 7.1503 (0.9); 7.0857 (1.6); 7.0696 (2.1); 7.0501 (1.0); 4.7345 (2.2); 4.6951 (2.5); 4.6192 (0.6); 4.2853 (2.8); 4.2456 (2.4); 3.9014 (0.8); 3.8920 (1.2); 3.8815 (1.6); 3.8720 (1.2); 3.8615 (0.9); 3.3604 (1.6); 3.3239 (383.6); 3.2732 (0.9); 3.2547 (0.6); 3.2178 (4.1); 3.2098 (3.5); 3.2035 (3.9); 3.1999 (4.0); 3.1922 (3.5); 3.1784 (1.6); 3.1682 (1.7); 3.1587 (0.6); 2.7281 (1.8); 2.7166 (1.8); 2.6989 (2.8); 2.6881 (2.5); 2.6742 (3.8); 2.6694 (4.3); 2.6648 (3.0); 2.6603 (1.3); 2.5368 (1.7); 2.5229 (10.8); 2.5182 (16.4); 2.5095 (227.4); 2.5050 (496.0); 2.5003 (692.8); 2.4957 (481.1); 2.4911 (214.4); 2.4666 (2.4); 2.4506 (3.4); 2.4299 (2.8); 2.4254 (1.8); 2.4105 (2.4); 2.3898 (2.6); 2.3364 (1.5); 2.3318 (3.1); 2.3271 (4.3); 2.3225 (3.0); 2.3178 (1.4); 2.2761 (1.2); 2.2633 (1.2); 2.2517 (2.0); 2.2390 (1.8); 2.2106 (1.5); 2.2040 (2.1); 2.1897 (1.2); 2.1780 (1.0); 2.1723 (0.9); 2.1597 (1.4); 2.1401 (0.8); 2.1351 (0.9); 2.0722 (1.1); 1.6868 (1.2); 1.6756 (1.2); 1.6644 (1.0); 1.6460 (0.9); 1.6328 (0.8); 1.6204 (0.5); 1.1575 (0.8); 1.0315 (6.0); 1.0138 (14.6); 0.9960 (6.0); 0.9754 (7.1); 0.9577 (16.0); 0.9400 (6.9); 0.8308 (0.5); 0.0080 (5.1); -0.0002 (202.4); -0.0085 (6.1); -0.1497 (0.7) I.1-123:1H NMR (400.0MHz, d6-DMSO): δ= 7.3884 (4.8); 7.3795 (0.7); 7.3690 (14.0); 7.3502 (16.0); 7.3445 (8.1); 7.3401 (14.3); 7.3356 (10.6); 7.3245 (2.9); 7.3195 (4.9); 7.3157 (3.1); 7.2916 (10.7); 7.2875 (15.5); 7.2014 (6.8); 7.1976 (12.0); 7.1943 (12.2); 7.1838 (5.6); 7.1798 (8.5); 7.0624 (13.2); 6.9306 (6.7); 4.6605 (0.5); 4.6209 (10.1); 4.5816 (11.3); 4.1542 (11.4); 4.1281 (1.0); 4.1150 (10.0); 3.8273 (2.4); 3.8168 (4.3); 3.8062 (5.6); 3.7952 (6.2); 3.7854 (5.8); 3.7750 (4.8); 3.7646 (3.1); 3.7503 (1.7); 3.7394 (1.7); 3.7280 (1.7); 3.7191 (1.7); 3.7084 (1.7); 3.5969 (1.8); 3.1681 (1.1); 2.8244 (5.8); 2.8141 (6.1); 2.7849 (7.3); 2.7747 (7.2); 2.6746 (0.8); 2.6700 (1.1); 2.6651 (1.1); 2.5235 (0.7); 2.5187 (1.9); 2.5101 (61.4); 2.5055 (134.0); 2.5009 (188.0); 2.4963 (138.2); 2.4918 (67.5); 2.4570 (9.2); 2.4481 (3.3); 2.4345 (7.3); 2.4237 (3.7); 2.4176 (6.6); 2.4056 (6.2); 2.3952 (6.9); 2.3872 (5.9); 2.3827 (5.2); 2.3639 (4.5); 2.3411 (0.9); 2.3372 (0.8); 2.3323 (1.2); 2.3277 (1.5); 2.3230 (1.4); 2.3159 (4.1); 2.3024 (4.9); 2.2916 (6.1); 2.2783 (6.3); 2.2610 (2.2); 2.2496 (3.6); 2.2368 (3.7); 2.2035 (2.4); 2.1845 (3.8); 2.1795 (2.3); 2.1720 (3.1); 2.1656 (2.8); 2.1601 (3.3); 2.1531 (4.5); 2.1479 (3.0); 2.1414 (2.1); 2.1336 (2.8); 2.1286 (3.3); 2.1167 (0.7); 2.1094 (1.6); 2.0720 (0.7); 1.7414 (1.8); 1.7293 (3.0); 1.7180 (4.0); 1.7075 (3.6); 1.6974 (3.7); 1.6862 (3.8); 1.6751 (2.5); 1.6621 (1.7); 1.1797 (0.7); -0.0002 (5.8) I.1-124:1H NMR (400.0MHz, d6-DMSO): δ= 7.1459 (1.6); 7.1259 (4.8); 7.1077 (5.4); 7.1023 (1.1); 7.0871 (1.6); 4.6490 (1.4); 4.6108 (1.6); 4.0551 (1.6); 4.0387 (1.3); 4.0209 (4.3); 4.0039 (4.3); 3.9860 (1.4); 3.7248 (0.6); 3.7143 (0.8); 3.7042 (0.9); 3.6939 (0.8); 3.6834 (0.6); 3.3154 (45.4); 3.1852 (2.3); 2.7296 (1.2); 2.7194 (1.2); 2.6900 (1.6); 2.6797 (1.6); 2.5233 (1.3); 2.5186 (1.8); 2.5100 (22.8); 2.5054 (49.3); 2.5007 (68.3); 2.4961 (47.2); 2.4915 (20.7); 2.4263 (1.8); 2.4045 (1.7); 2.3940 (0.9); 2.3867 (1.4); 2.3751 (0.7); 2.3699 (0.7); 2.3649 (1.4); 2.3520 (0.6); 2.2875 (0.9); 2.2760 (11.4); 2.2631 (1.2); 2.2493 (1.0); 2.2212 (0.6); 2.2078 (0.6); 2.1496 (0.5); 2.1194 (0.6); 1.6969 (0.7); 1.6763 (0.5); 1.6649 (0.6); 1.1525 (7.1); 1.1347 (16.0); 1.1169 (7.0); -0.0002 (2.4) I.1-125:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.5747 (4.1); 7.5683 (4.3); 7.3791 (2.0); 7.3727 (1.8); 7.3569 (2.5); 7.3504 (2.4); 7.1933 (4.2); 7.1711 (3.2); 7.1252 (2.0); 7.1047 (7.4); 7.0904 (7.9); 7.0699 (2.0); 4.6527 (2.0); 4.6146 (2.3); 4.3580 (1.1); 4.3477 (2.9); 4.3382 (3.2); 4.3291 (1.7); 4.2560 (3.3); 4.2452 (3.8); 4.2342 (1.8); 4.0414 (2.3); 4.0033 (2.0); 3.7206 (0.7); 3.7099 (1.0); 3.6993 (1.2); 3.6890 (1.0); 3.6787 (0.7); 3.3295 (328.1); 3.2978 (0.6); 3.1673 (0.5); 2.7824 (1.3); 2.7724 (1.3); 2.7427 (1.7); 2.7327 (1.6); 2.6703 (0.8); 2.5099 (51.5); 2.5056 (105.7); 2.5012 (142.7); 2.4968 (101.0); 2.4926 (46.9); 2.4634 (2.0); 2.4412 (1.8); 2.4236 (1.8); 2.4017 (1.8); 2.3805 (1.2); 2.3628 (1.0); 2.3388 (1.0); 2.3328 (0.8); 2.3284 (0.9); 2.2613 (16.0); 2.2417 (1.3); 2.2279 (1.2); 2.1998 (0.7); 2.1866 (0.8); 2.1284 (0.8); 2.1158 (0.6); 2.1040 (0.6); 2.0975 (0.9); 2.0729 (0.9); 1.7164 (0.6); 1.7040 (0.8); 1.6929 (0.8); 1.6840 (0.7); 1.6721 (0.7); 1.6610 (0.5); -0.0002 (1.4) I.1-126:1H NMR (400.0MHz, d6-DMSO): δ= 7.2940 (1.2); 7.2719 (1.4); 7.1073 (1.8); 7.0975 (1.9); 6.8472 (1.3); 6.8251 (1.2); 4.3066 (0.7); 4.2947 (0.8); 4.1145 (0.6); 4.1033 (1.1); 4.0515 (0.5); 3.5111 (1.0); 2.5103 (2.3); 2.5059 (4.9); 2.5014 (6.6); 2.4969 (4.7); 2.4925 (2.2); 2.2609 (3.5); 1.2449 (16.0) I.1-127:1H NMR (400.1 MHz, d6-DMSO): δ= 7.3803 (2.0); 7.3765 (2.2); 7.3596 (4.3); 7.3560 (4.9); 7.3503 (2.7); 7.3400 (3.0); 7.3340 (4.9); 7.3303 (4.4); 7.3136 (2.5); 7.3101 (2.5); 7.2090 (2.5); 7.2052 (2.9); 7.1946 (9.0); 7.1894 (5.9); 7.1856 (5.6); 7.1761 (4.8); 7.1729 (5.4); 7.1690 (3.6); 7.1650 (3.2); 7.1559 (2.6); 7.1526 (2.8); 7.0723 (5.4); 7.0629 (16.0); 7.0566 (8.2); 7.0369 (3.8); 6.9312 (7.1); 4.7048 (8.2); 4.6648 (9.6); 4.4857 (0.3); 4.4346 (0.3); 4.3883 (0.3); 4.3790 (0.3); 4.3558 (0.3); 4.3214 (0.4); 4.3090 (0.4); 4.2590 (10.2); 4.2189 (8.7); 4.1710 (0.4); 4.1520 (0.4); 4.1467 (0.4); 4.1134 (0.4); 4.0808 (0.4); 4.0718 (0.4); 4.0420 (0.4); 4.0184 (0.4); 3.9887 (0.4); 3.9614 (0.3); 3.9413 (0.3); 3.9202 (0.4); 3.8772 (0.4); 3.8585 (1.8); 3.8483 (3.3); 3.8376 (4.6); 3.8273 (5.2); 3.8171 (4.5); 3.8069 (3.6); 3.7970 (1.7); 3.1694 (0.5); 2.8330 (6.0); 2.8230 (6.2); 2.7935 (7.6); 2.7835 (7.5); 2.6743 (0.7); 2.6696 (0.9); 2.6650 (0.7); 2.5567 (0.6); 2.5522 (0.9); 2.5495 (1.0); 2.5448 (0.8); 2.5230 (2.3); 2.5166 (9.3); 2.5098 (43.7); 2.5053 (97.0); 2.5007 (138.0); 2.4960 (106.3); 2.4916 (51.6); 2.4774 (7.1); 2.4552 (6.4); 2.4478 (2.8); 2.4286 (2.4); 2.4214 (2.2); 2.4054 (5.5); 2.3868 (4.7); 2.3829 (4.6); 2.3655 (3.1); 2.3433 (0.5); 2.3369 (0.4); 2.3322 (0.6); 2.3275 (1.0); 2.3228 (0.8); 2.3018 (3.4); 2.2894 (3.9); 2.2775 (5.8); 2.2651 (5.9); 2.2490 (0.8); 2.2359 (3.9); 2.2272 (6.8); 2.2110 (4.0); 2.1993 (3.1); 2.1927 (2.6); 2.1865 (2.3); 2.1805 (4.6); 2.1754 (2.5); 2.1684 (1.6); 2.1609 (2.6); 2.1561 (3.0); 2.1368 (1.3); 2.0710 (1.2); 1.7703 (1.8); 1.7623 (3.6); 1.7509 (3.5); 1.7401 (3.9); 1.7332 (3.8); 1.7281 (2.6); 1.7207 (3.0); 1.7080 (2.7); 1.6961 (1.5); 0.0082 (0.9) I.1-128:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1469 (2.1); 7.1261 (7.1); 7.1102 (7.6); 7.0899 (2.2); 4.6575 (2.0); 4.6196 (2.3); 4.1138 (1.7); 4.1029 (4.5); 4.0911 (4.6); 4.0808 (1.7); 4.0566 (2.4); 4.0190 (2.0); 3.7240 (0.9); 3.7131 (1.1); 3.7018 (1.2); 3.6920 (1.1); 3.6827 (0.9); 3.4783 (4.2); 3.4669 (6.9); 3.4550 (4.8); 3.4196 (41.7); 3.2278 (28.7); 2.7612 (1.3); 2.7512 (1.4); 2.7216 (1.8); 2.7114 (1.8); 2.6696 (0.6); 2.5100 (29.7); 2.5056 (61.9); 2.5012 (84.2); 2.4967 (59.5); 2.4924 (27.3); 2.4547 (1.9); 2.4326 (2.1); 2.4152 (1.6); 2.4037 (1.4); 2.3933 (1.7); 2.3859 (1.1); 2.3623 (0.8); 2.2763 (16.0); 2.2615 (1.3); 2.2479 (1.3); 2.2316 (0.6); 2.2195 (0.7); 2.2060 (0.8); 2.1495 (0.8); 2.1168 (1.0); 2.0926 (0.8); 2.0728 (0.7); 1.7116 (0.6); 1.7008 (1.0); 1.6805 (0.8); 1.6687 (0.8); 1.6583 (0.6); -0.0002 (1.6) I.1-129:1H NMR (400.0MHz, d6-DMSO): δ= 7.3751 (16.0); 7.1396 (1.2); 7.1196 (2.9); 7.0922 (3.1); 7.0721 (1.3); 4.6374 (0.9); 4.5992 (1.0); 4.1524 (1.2); 4.1363 (2.7); 4.1203 (1.3); 4.0416 (1.1); 4.0032 (0.9); 3.6729 (0.6); 3.4076 (8.0); 3.2032 (1.3); 3.1872 (2.7); 3.1710 (1.2); 2.7032 (0.6); 2.6930 (0.6); 2.6635 (0.8); 2.6533 (0.8); 2.5068 (9.7); 2.5024 (13.1); 2.4981 (9.3); 2.3815 (1.2); 2.3602 (1.2); 2.3420 (0.8); 2.3203 (0.7); 2.2714 (7.2); 2.2547 (0.6); 2.2406 (0.6) I.1-130:1H NMR (400.0MHz, d6-DMSO): δ= 10.6935 (0.5); 7.8181 (3.9); 7.3656 (0.9); 7.3437 (0.8); 7.1954 (0.9); 7.1826 (0.9); 7.1068 (0.8); 7.0899 (1.1); 7.0717 (0.6); 4.7752 (1.1); 4.7356 (1.3); 4.2913 (1.5); 4.2517 (1.4); 3.9036 (0.6); 3.8934 (0.8); 3.8842 (0.8); 3.8722 (0.7); 3.8621 (0.6); 3.5968 (16.0); 3.3206 (69.7); 3.1858 (0.9); 3.1343 (0.7); 3.1224 (0.8); 3.1161 (2.4); 3.1041 (2.2); 3.0979 (2.2); 3.0860 (2.2); 3.0798 (0.7); 3.0679 (0.7); 2.8861 (0.6); 2.8763 (0.6); 2.8491 (0.8); 2.8389 (0.7); 2.7694 (0.8); 2.7609 (0.8); 2.6746 (0.9); 2.6699 (1.2); 2.6653 (0.8); 2.5504 (1.4); 2.5459 (1.0); 2.5402 (1.3); 2.5234 (4.2); 2.5186 (6.2); 2.5100 (67.6); 2.5054 (143.4); 2.5008 (197.1); 2.4962 (137.3); 2.4916 (61.3); 2.4690 (0.6); 2.4264 (1.0); 2.4082 (0.8); 2.4040 (0.8); 2.3869 (0.7); 2.3369 (0.5); 2.3322 (1.0); 2.3276 (1.8); 2.3231 (1.0); 2.3150 (0.7); 2.3031 (1.0); 2.2904 (1.0); 2.2615 (0.7); 2.2508 (1.1); 2.2339 (0.8); 2.2219 (0.6); 2.2154 (0.5); 2.2034 (0.8); 2.1783 (0.6); 1.8628 (0.5); 1.8517 (0.6); 1.8405 (0.6); 1.8332 (0.6); 1.8209 (0.5); 1.1937 (5.4); 1.1755 (11.2); 1.1572 (5.2); 0.0079 (1.6); -0.0002 (51.9); -0.0086 (1.5) I.1-131:1H NMR (400.1 MHz, i.e6-DMSO): δ= 12.3518 (0.4); 12.3435 (0.4); 12.3082 (0.4); 12.2984 (0.3); 7.4050 (1.1); 7.3986 (11.0); 7.3938 (3.9); 7.3825 (4.3); 7.3775 (16.0); 7.3713 (2.1); 7.2635 (12.0); 7.2423 (9.1); 4.6561 (4.4); 4.6174 (5.0); 4.1363 (4.8); 4.0974 (4.3); 3.7350 (0.7); 3.7243 (1.4); 3.7134 (2.0); 3.7023 (2.1); 3.6927 (2.0); 3.6825 (1.6); 3.6723 (0.8); 3.3610 (29.7); 3.1686 (3.1); 2.6860 (3.4); 2.6761 (3.7); 2.6690 (1.5); 2.6643 (1.0); 2.6594 (0.6); 2.6463 (4.1); 2.6364 (4.0); 2.5487 (0.9); 2.5441 (1.2); 2.5394 (1.8); 2.5224 (2.7); 2.5091 (70.4); 2.5045 (154.6); 2.4999 (218.8); 2.4953 (158.4); 2.4907 (75.2); 2.4564 (1.0); 2.4517 (0.4); 2.4417 (0.4); 2.4243 (1.1); 2.4169 (1.1); 2.4000 (2.4); 2.3825 (1.9); 2.3764 (1.8); 2.3591 (1.7); 2.3358 (0.6); 2.3313 (1.2); 2.3258 (5.1); 2.3176 (0.9); 2.3030 (4.1); 2.2923 (2.0); 2.2861 (3.8); 2.2786 (2.2); 2.2678 (3.0); 2.2634 (3.9); 2.2540 (2.9); 2.2374 (0.8); 2.2262 (1.7); 2.2133 (1.8); 2.1972 (1.2); 2.1789 (1.5); 2.1730 (0.8); 2.1668 (1.4); 2.1614 (1.1); 2.1541 (1.1); 2.1487 (1.8); 2.1424 (1.2); 2.1369 (0.9); 2.1295 (1.2); 2.1233 (1.2); 2.1047 (0.7); 2.0709 (0.7); 1.7362 (0.9); 1.7240 (1.4); 1.7128 (1.8); 1.7015 (1.4); 1.6936 (1.6); 1.6883 (1.2); 1.6813 (1.7); 1.6702 (1.1); 1.6561 (0.7); 0.0082 (0.7); 0.0000 (23.2) I.1-132:1H NMR (400.1 MHz, i.e6-DMSO): δ= 11.6290 (3.4); 7.3855 (0.4); 7.3818 (0.5); 7.3649 (1.0); 7.3611 (1.1); 7.3553 (0.6); 7.3452 (0.7); 7.3391 (1.1); 7.3353 (1.0); 7.3189 (0.6); 7.3151 (0.5); 7.2120 (0.6); 7.2081 (0.6); 7.1992 (0.6); 7.1954 (0.8); 7.1920 (1.1); 7.1884 (1.2); 7.1792 (1.1); 7.1760 (1.2); 7.1720 (0.8); 7.1679 (0.8); 7.1589 (0.6); 7.1554 (0.7); 7.0760 (1.1); 7.0599 (1.6); 7.0569 (1.5); 7.0406 (0.8); 4.7255 (1.8); 4.6858 (2.1); 4.2447 (2.2); 4.2045 (1.9); 3.8415 (0.4); 3.8311 (0.7); 3.8205 (1.0); 3.8099 (1.1); 3.7996 (1.0); 3.7898 (0.8); 3.7800 (0.4); 3.5958 (0.7); 3.5787 (1.8); 3.5615 (2.6); 3.5443 (1.9); 3.5271 (0.7); 3.3514 (45.5); 3.1684 (5.7); 2.7907 (1.5); 2.7807 (1.5); 2.7524 (1.8); 2.7424 (1.8); 2.6742 (0.5); 2.6696 (0.7); 2.6650 (0.5); 2.5446 (0.4); 2.5400 (0.9); 2.5231 (1.6); 2.5184 (2.5); 2.5098 (38.6); 2.5052 (84.3); 2.5006 (118.7); 2.4960 (86.2); 2.4914 (41.1); 2.4656 (2.4); 2.4433 (2.0); 2.4272 (1.7); 2.4157 (0.7); 2.4051 (1.7); 2.3988 (1.4); 2.3796 (1.2); 2.3763 (1.1); 2.3578 (0.9); 2.3320 (0.5); 2.3274 (0.8); 2.3228 (0.6); 2.3040 (0.8); 2.2916 (1.0); 2.2798 (1.4); 2.2673 (1.4); 2.2380 (0.8); 2.2271 (1.0); 2.2219 (0.8); 2.2039 (0.9); 2.1978 (0.4); 2.1922 (0.7); 2.1850 (0.6); 2.1795 (0.6); 2.1730 (1.1); 2.1684 (0.6); 2.1608 (0.4); 2.1534 (0.6); 2.1488 (0.7); 2.0721 (0.7); 1.7729 (0.4); 1.7633 (0.8); 1.7520 (0.8); 1.7415 (0.9); 1.7332 (1.0); 1.7292 (0.6); 1.7213 (0.7); 1.7092 (0.6); 1.6974 (0.4); 1.2611 (15.5); 1.2593 (16.0); 1.2439 (15.5); 1.2422 (16.0); 0.0083 (0.5) I.1-133:1H NMR (400.1 MHz, d6-DMSO): δ= 7.5844 (6.7); 7.5807 (7.4); 7.5644 (8.5); 7.5607 (8.7); 7.3707 (8.1); 7.3511 (16.0); 7.3313 (9.2); 7.2291 (7.7); 7.2273 (7.2); 7.2256 (8.2); 7.2098 (6.2); 7.2062 (6.2); 4.7040 (7.5); 4.6628 (9.2); 4.3067 (8.8); 4.2654 (7.4); 3.8384 (1.3); 3.8279 (2.5); 3.8173 (3.6); 3.8074 (4.1); 3.7979 (3.6); 3.7874 (2.9); 3.7769 (1.3); 3.7634 (0.4); 3.7424 (0.4); 3.5954 (1.0); 3.5574 (0.8); 3.5198 (0.6); 2.6743 (5.6); 2.6637 (5.7); 2.6344 (7.3); 2.6237 (7.2); 2.5507 (0.3); 2.5460 (0.3); 2.5407 (0.4); 2.5238 (0.7); 2.5191 (1.1); 2.5105 (21.2); 2.5059 (47.2); 2.5013 (67.0); 2.4966 (48.9); 2.4921 (23.6); 2.4808 (2.8); 2.4628 (2.5); 2.4516 (1.0); 2.4492 (1.0); 2.4391 (5.0); 2.4324 (8.3); 2.4224 (3.8); 2.4161 (4.4); 2.4109 (8.2); 2.3925 (6.3); 2.3709 (5.8); 2.3322 (2.8); 2.3198 (2.7); 2.3078 (5.0); 2.2958 (5.1); 2.2740 (3.6); 2.2701 (5.7); 2.2636 (4.9); 2.2613 (4.7); 2.2579 (3.9); 2.2525 (2.6); 2.2470 (1.5); 2.2402 (3.6); 2.2334 (1.5); 2.2280 (1.2); 2.2212 (2.2); 2.2155 (1.9); 2.1969 (1.0); 2.0720 (14.2); 1.8181 (0.9); 1.8127 (0.6); 1.7960 (1.8); 1.7906 (2.2); 1.7841 (3.3); 1.7768 (2.3); 1.7735 (3.0); 1.7668 (2.0); 1.7613 (2.8); 1.7541 (2.1); 1.7424 (2.4); 1.7305 (1.3); 0.0000 (8.9) I.1-134:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.1491 (1.0); 8.1259 (0.9); 8.0619 (1.0); 8.0387 (1.0); 7.2207 (2.8); 7.2080 (7.7); 7.1973 (1.0); 7.1550 (2.3); 7.1410 (3.2); 7.1365 (4.8); 4.7742 (1.6); 4.7675 (1.8); 4.7354 (1.8); 4.7284 (2.0); 4.3341 (1.0); 4.3225 (1.2); 4.3122 (1.2); 4.3007 (1.1); 4.1557 (0.8); 4.1407 (0.9); 4.1197 (0.7); 4.0955 (0.7); 4.0630 (2.0); 4.0249 (1.6); 3.6475 (1.1); 3.3868 (1.0); 3.3332 (112.0); 3.2832 (1.8); 3.1655 (2.6); 2.6744 (1.6); 2.6698 (2.5); 2.6652 (1.8); 2.6255 (1.9); 2.6091 (4.5); 2.5905 (5.3); 2.5715 (2.6); 2.5617 (2.4); 2.5567 (2.4); 2.5519 (1.7); 2.5233 (4.7); 2.5186 (7.5); 2.5099 (139.3); 2.5053 (308.9); 2.5007 (435.6); 2.4960 (304.6); 2.4915 (135.2); 2.4549 (4.4); 2.4504 (6.4); 2.4458 (5.2); 2.3856 (1.6); 2.3320 (2.1); 2.3275 (2.6); 2.3228 (2.2); 2.3120 (1.7); 2.2777 (2.2); 2.2539 (1.5); 2.2202 (0.8); 2.0730 (0.8); 2.0333 (0.9); 2.0050 (1.1); 1.9821 (1.0); 1.8305 (1.6); 1.2443 (0.9); 1.1439 (6.3); 1.1403 (4.4); 1.1253 (13.2); 1.1215 (8.8); 1.1063 (6.2); 1.1026 (4.3); 0.8546 (7.6); 0.8475 (11.5); 0.8375 (10.4); 0.8294 (16.0); 0.8106 (4.0); 0.0506 (1.1); 0.0079 (5.7); -0.0002 (207.1); -0.0085 (6.1); -0.0506 (2.2) I.1-135:1H NMR (400.0MHz, d6-DMSO): δ= 8.6528 (0.6); 8.6380 (1.2); 8.6238 (0.6); 8.5781 (1.1); 8.5760 (1.3); 8.5739 (1.3); 8.5718 (1.2); 8.5654 (1.2); 8.5634 (1.3); 8.5613 (1.3); 8.5591 (1.1); 7.9472 (0.5); 7.9318 (1.0); 7.9285 (1.0); 7.9123 (0.6); 7.9089 (0.6); 7.4323 (0.8); 7.4190 (0.9); 7.3988 (1.8); 7.3775 (1.6); 7.3603 (0.7); 7.3563 (0.8); 7.3501 (0.4); 7.3407 (0.5); 7.3344 (0.8); 7.3305 (0.7); 7.3142 (0.4); 7.3104 (0.4); 7.2071 (0.4); 7.2031 (0.5); 7.1942 (0.4); 7.1903 (0.6); 7.1873 (0.8); 7.1833 (0.9); 7.1745 (0.8); 7.1708 (0.9); 7.1668 (0.6); 7.1629 (0.6); 7.1541 (0.5); 7.1504 (0.5); 7.0785 (0.8); 7.0628 (1.1); 7.0593 (1.1); 7.0432 (0.6); 4.7472 (1.3); 4.7077 (1.5); 4.3997 (2.5); 4.3840 (2.4); 4.2485 (1.6); 4.2086 (1.4); 3.8481 (0.4); 3.8371 (0.6); 3.8266 (0.9); 3.8166 (1.1); 3.8067 (0.9); 3.7961 (0.7); 3.7848 (0.5); 3.7295 (0.4); 3.5405 (16.0); 3.1687 (4.8); 2.6757 (0.4); 2.6710 (0.5); 2.6664 (0.4); 2.6508 (1.1); 2.6396 (1.1); 2.6155 (1.4); 2.6042 (1.3); 2.5413 (0.4); 2.5244 (0.8); 2.5198 (1.2); 2.5111 (26.6); 2.5065 (60.5); 2.5019 (86.4); 2.4973 (61.2); 2.4926 (27.2); 2.4625 (0.4); 2.4577 (0.4); 2.4533 (0.4); 2.4114 (0.4); 2.3924 (0.5); 2.3886 (0.5); 2.3693 (1.0); 2.3449 (2.1); 2.3332 (0.6); 2.3282 (1.2); 2.3234 (1.9); 2.3094 (1.3); 2.2913 (0.9); 2.2878 (1.4); 2.2783 (0.9); 2.2674 (1.1); 2.2542 (1.1); 2.2498 (0.5); 2.2366 (0.4); 2.2255 (0.6); 2.2125 (0.6); 2.1656 (0.4); 2.1464 (0.7); 2.1419 (0.4); 2.1341 (0.5); 2.1270 (0.4); 2.1222 (0.6); 2.1148 (0.9); 2.1101 (0.5); 2.0954 (0.5); 2.0907 (0.6); 2.0735 (4.4); 1.8185 (0.4); 1.8059 (0.5); 1.7951 (0.7); 1.7847 (0.6); 1.7737 (0.6); 1.7634 (0.7); 1.7529 (0.4) I.1-136:1H NMR (400.1 MHz, d6-DMSO): δ= 7.4210 (6.6); 7.3999 (16.0); 7.3939 (12.1); 7.3788 (12.0); 7.3729 (15.2); 7.3517 (7.3); 7.3017 (5.6); 7.2966 (5.8); 7.2821 (5.9); 7.2767 (6.8); 7.2729 (6.5); 7.2675 (6.0); 7.2530 (5.6); 7.2479 (5.6); 7.1011 (5.8); 7.0947 (5.9); 7.0902 (6.2); 7.0849 (6.1); 7.0798 (5.4); 7.0738 (5.2); 7.0693 (5.1); 6.8936 (7.3); 4.6306 (12.5); 4.5918 (14.5); 4.1363 (15.9); 4.0974 (13.7); 3.7886 (2.3); 3.7773 (5.2); 3.7663 (6.5); 3.7571 (7.5); 3.7465 (6.8); 3.7355 (5.5); 3.7242 (2.6); 3.3864 (1.7); 3.3774 (0.8); 3.3371 (642.8); 3.2858 (0.5); 3.2699 (0.4); 3.1703 (0.7); 2.6803 (0.4); 2.6757 (0.9); 2.6711 (1.3); 2.6666 (1.0); 2.6619 (0.4); 2.5558 (0.3); 2.5513 (0.5); 2.5467 (0.5); 2.5415 (0.5); 2.5247 (3.1); 2.5199 (4.4); 2.5112 (76.3); 2.5067 (164.1); 2.5021 (231.1); 2.4976 (158.5); 2.4930 (75.4); 2.4664 (12.9); 2.4552 (12.2); 2.4024 (2.5); 2.3841 (3.3); 2.3791 (3.1); 2.3606 (8.3); 2.3421 (7.4); 2.3373 (7.2); 2.3291 (2.1); 2.3191 (7.0); 2.2992 (6.4); 2.2846 (7.7); 2.2752 (9.1); 2.2608 (9.4); 2.2429 (2.9); 2.2333 (4.4); 2.2191 (4.3); 2.1494 (3.2); 2.1300 (6.9); 2.1253 (14.6); 2.1178 (5.0); 2.1116 (4.4); 2.1027 (13.5); 2.0897 (11.6); 2.0800 (4.5); 2.0747 (5.5); 2.0717 (4.2); 2.0675 (9.9); 2.0562 (2.5); 1.7439 (3.0); 1.7301 (4.2); 1.7193 (5.0); 1.7118 (4.1); 1.7088 (4.7); 1.6980 (4.6); 1.6948 (3.8); 1.6870 (4.3); 1.6769 (3.4); 1.6627 (2.4) I.1-137:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.0177 (7.8); 9.0141 (8.9); 9.0070 (8.2); 9.0031 (8.7); 8.6645 (5.0); 8.6437 (5.5); 8.5983 (3.3); 8.5842 (6.2); 8.0113 (8.1); 7.9896 (10.5); 7.8133 (7.6); 7.7952 (9.4); 7.7741 (7.4); 7.6981 (5.9); 7.6869 (6.0); 7.6764 (5.6); 7.6656 (6.3); 7.5930 (9.0); 7.5756 (7.9); 7.3724 (2.3); 7.3522 (5.1); 7.3304 (4.8); 7.3059 (2.5); 7.1919 (2.8); 7.1723 (5.6); 7.1595 (5.2); 7.1428 (2.7); 7.0663 (4.3); 7.0513 (6.0); 7.0321 (3.8); 4.8225 (2.4); 4.8076 (2.5); 4.7849 (6.2); 4.7704 (6.5); 4.7398 (6.6); 4.7247 (8.7); 4.7017 (3.8); 4.6810 (7.9); 4.2205 (8.8); 4.1807 (7.9); 3.8393 (12.3); 3.8284 (14.2); 3.8170 (15.8); 3.8076 (16.0); 3.7981 (15.4); 3.2169 (2.0); 3.1660 (14.6); 2.7573 (2.0); 2.6750 (3.6); 2.6701 (5.2); 2.6655 (4.4); 2.6221 (5.0); 2.6112 (5.4); 2.5870 (6.2); 2.5760 (6.7); 2.5566 (2.5); 2.5237 (8.2); 2.5190 (14.1); 2.5103 (317.8); 2.5057 (712.5); 2.5011 (1013.9); 2.4965 (712.6); 2.4919 (319.1); 2.4557 (7.8); 2.4510 (10.0); 2.4464 (7.4); 2.4012 (2.7); 2.3753 (2.6); 2.3564 (3.2); 2.3325 (9.5); 2.3280 (7.1); 2.3232 (5.2); 2.3131 (5.7); 2.2975 (8.2); 2.2895 (5.6); 2.2755 (8.6); 2.2698 (5.8); 2.2624 (7.9); 2.2561 (6.1); 2.2455 (7.9); 2.2407 (7.7); 2.2324 (6.4); 2.2146 (3.2); 2.2038 (3.8); 2.1908 (3.9); 2.1485 (2.5); 2.1291 (3.9); 2.1050 (3.2); 2.0978 (4.9); 2.0734 (6.6); 2.0544 (1.7); 1.7691 (1.9); 1.7562 (3.2); 1.7457 (4.0); 1.7322 (3.6); 1.7138 (3.4); 1.7026 (2.6); 0.0505 (2.3); 0.0080 (18.1); 0.0063 (5.3); 0.0055 (5.9); 0.0047 (7.1); 0.0038 (9.5); -0.0002 (601.3); - 0.0027 (33.5); -0.0051 (8.4); -0.0060 (5.9); -0.0068 (5.3); -0.0085 (17.3); -0.0504 (4.4) I.1-139:1H NMR (400.0 MHz, d6-DMSO): δ= 7.4300 (2.3); 7.4261 (2.5); 7.4103 (2.6); 7.4063 (2.6); 7.3109 (1.0); 7.3070 (1.1); 7.2901 (2.0); 7.2717 (1.6); 7.2677 (1.4); 7.1583 (2.5); 7.1551 (2.6); 7.1375 (2.0); 7.1342 (2.0); 7.1266 (2.0); 7.1059 (7.5); 7.0927 (8.0); 7.0721 (2.0); 6.9891 (1.5); 6.9857 (1.5); 6.9698 (2.2); 6.9667 (2.2); 6.9509 (1.2); 6.9475 (1.1); 4.6533 (2.0); 4.6148 (2.2); 4.3963 (0.8); 4.3654 (1.2); 4.3547 (3.2); 4.3445 (3.3); 4.3350 (1.6); 4.2451 (3.3); 4.2340 (4.5); 4.2227 (2.2); 4.0468 (2.3); 4.0084 (2.0); 3.7270 (0.7); 3.7164 (1.0); 3.7062 (1.1); 3.6960 (1.0); 3.6853 (0.7); 3.3456 (0.8); 3.3231 (348.6); 3.2993 (19.9); 3.2734 (1.4); 2.7850 (1.4); 2.7751 (1.4); 2.7455 (1.8); 2.7354 (1.7); 2.6704 (0.7); 2.5237 (1.7); 2.5102 (43.8); 2.5057 (93.7); 2.5012 (129.4); 2.4967 (92.7); 2.4923 (43.5); 2.4651 (2.1); 2.4429 (2.0); 2.4254 (1.9); 2.4035 (1.9); 2.3813 (1.2); 2.3636 (1.0); 2.3397 (0.9); 2.3326 (0.7); 2.3280 (0.8); 2.2609 (16.0); 2.2412 (1.4); 2.2275 (1.2); 2.1994 (0.8); 2.1859 (0.8); 2.1525 (0.5); 2.1335 (0.8); 2.1205 (0.6); 2.1143 (0.6); 2.1087 (0.6); 2.1023 (1.0); 2.0777 (0.6); 1.7226 (0.7); 1.7116 (0.8); 1.7016 (0.7); 1.6915 (0.7); 1.6799 (0.8); 1.6684 (0.5); -0.0002 (7.5) I.1-140:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1469 (1.2); 7.1265 (4.1); 7.1094 (4.4); 7.0890 (1.3); 4.6566 (1.2); 4.6183 (1.3); 4.1470 (1.3); 4.1310 (2.8); 4.1146 (1.5); 4.0634 (1.4); 4.0255 (1.3); 3.7225 (0.6); 3.7121 (0.7); 3.7018 (0.6); 3.3629 (60.9); 2.7634 (0.8); 2.7533 (0.8); 2.7238 (1.1); 2.7137 (1.0); 2.6616 (2.2); 2.6450 (4.4); 2.6284 (2.0); 2.5098 (16.5); 2.5056 (34.2); 2.5012 (46.7); 2.4968 (33.3); 2.4926 (15.6); 2.4501 (1.2); 2.4280 (1.3); 2.4104 (0.9); 2.4026 (0.7); 2.3882 (1.0); 2.3788 (0.6); 2.2905 (0.6); 2.2762 (9.8); 2.2664 (1.0); 2.2524 (0.7); 2.1279 (0.5); 2.0600 (16.0); 1.7180 (0.5) I.1-142:1H NMR (400.0MHz, d6-DMSO): δ= 7.1471 (2.0); 7.1270 (5.9); 7.1079 (6.5); 7.0874 (2.0); 4.6492 (1.8); 4.6111 (2.0); 4.0552 (2.0); 4.0382 (1.5); 4.0203 (5.5); 4.0029 (5.1); 3.9851 (1.7); 3.7231 (0.7); 3.7126 (1.0); 3.7022 (1.1); 3.6920 (1.0); 3.6815 (0.7); 3.4004 (1.7); 3.3681 (218.9); 3.1673 (0.6); 2.7323 (1.4); 2.7221 (1.4); 2.6927 (1.8); 2.6824 (1.8); 2.6759 (0.6); 2.6714 (0.8); 2.6667 (0.6); 2.5416 (0.7); 2.5248 (2.2); 2.5201 (3.2); 2.5114 (48.6); 2.5069 (103.0); 2.5023 (138.9); 2.4977 (96.6); 2.4931 (43.3); 2.4272 (2.0); 2.4199 (0.5); 2.4121 (0.5); 2.4053 (2.0); 2.3952 (1.2); 2.3876 (1.6); 2.3766 (0.8); 2.3710 (0.8); 2.3657 (1.6); 2.3532 (0.8); 2.3336 (0.6); 2.3291 (0.8); 2.3244 (0.6); 2.2887 (1.0); 2.2761 (14.5); 2.2643 (1.5); 2.2504 (1.2); 2.2224 (0.7); 2.2090 (0.8); 2.1501 (0.7); 2.1371 (0.6); 2.1313 (0.5); 2.1247 (0.5); 2.1185 (0.8); 2.1126 (0.5); 2.0993 (0.5); 2.0934 (0.5); 2.0752 (0.6); 1.7062 (0.6); 1.6952 (0.8); 1.6843 (0.6); 1.6745 (0.6); 1.6632 (0.7); 1.1521 (7.4); 1.1343 (16.0); 1.1165 (7.2); -0.0002 (8.8) I.1-143:1H NMR (400.0MHz, d6-DMSO): δ= 7.9947 (5.4); 7.9910 (5.3); 7.9734 (5.5); 7.9223 (2.0); 7.9024 (1.8); 7.7391 (2.6); 7.7241 (5.3); 7.7203 (5.7); 7.7078 (16.0); 7.7041 (13.2); 7.6893 (2.8); 7.6077 (3.8); 7.6024 (3.7); 7.5912 (3.7); 7.5880 (4.5); 7.5819 (3.7); 7.5722 (3.0); 7.5664 (2.4); 7.1599 (8.3); 7.1402 (11.6); 7.0972 (2.2); 7.0588 (12.5); 7.0388 (8.4); 4.5621 (4.4); 4.5244 (5.0); 4.2770 (5.7); 4.2642 (8.9); 4.2494 (6.7); 4.1467 (2.3); 3.9598 (5.2); 3.9205 (4.7); 3.8923 (6.1); 3.8768 (7.6); 3.8646 (4.6); 3.4881 (3.7); 3.4761 (5.0); 3.4642 (4.4); 3.4459 (3.7); 3.4324 (3.6); 3.3759 (2.2); 3.3502 (7.2); 3.3230 (3678.0); 3.2991 (180.8); 3.1748 (3.0); 3.1617 (2.9); 2.6749 (4.5); 2.6703 (6.3); 2.6658 (4.6); 2.5404 (3.8); 2.5236 (17.3); 2.5103 (395.8); 2.5057 (840.7); 2.5012 (1154.2); 2.4966 (811.6); 2.4922 (370.4); 2.3538 (4.1); 2.3432 (5.1); 2.3281 (8.0); 2.3234 (7.7); 2.3136 (4.9); 2.3031 (6.7); 2.2918 (34.9); 2.2653 (4.5); 2.2560 (2.6); 2.2406 (3.0); 2.2310 (3.2); 2.2168 (3.3); 2.1888 (1.9); 2.0729 (3.6); 2.0529 (2.2); 2.0205 (2.3); 1.9737 (4.2); 1.9517 (3.8); 1.9338 (3.4); 1.9117 (3.7); 1.5148 (1.8); -0.0002 (34.6) I.1-144:1H NMR (400.0 MHz, i.e6-DMSO): δ= 10.4881 (1.2); 8.1118 (0.9); 8.1095 (1.0); 8.0910 (1.0); 8.0887 (1.0); 7.8875 (1.0); 7.8838 (1.1); 7.8676 (1.1); 7.8640 (1.1); 7.6073 (0.6); 7.6032 (0.6); 7.5888 (0.7); 7.5852 (0.8); 7.5825 (0.6); 7.5681 (0.6); 7.5640 (0.6); 7.2204 (0.8); 7.2174 (0.8); 7.2019 (1.0); 7.2006 (1.0); 7.1991 (1.0); 7.1977 (1.0); 7.1823 (0.8); 7.1793 (0.8); 7.0880 (0.6); 4.7547 (0.7); 4.7150 (0.8); 4.3180 (0.9); 4.2781 (0.8); 3.9160 (0.5); 3.8292 (16.0); 3.3433 (14.2); 2.8442 (0.6); 2.8322 (0.6); 2.8069 (0.8); 2.7949 (0.7); 2.5970 (0.8); 2.5768 (0.7); 2.5596 (0.5); 2.5395 (0.7); 2.5240 (0.6); 2.5193 (0.8); 2.5106 (10.6); 2.5060 (22.8); 2.5014 (31.7); 2.4968 (22.1); 2.4922 (9.7); 2.4418 (0.7); 2.2978 (0.6); 2.2851 (0.6); 2.2484 (0.6); -0.0002 (2.8) I.1-145:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0020 (8.6); 7.9840 (6.4); 7.9805 (16.0); 7.7422 (5.7); 7.7370 (5.2); 7.7209 (4.6); 7.7157 (4.9); 7.1689 (5.4); 7.1495 (8.4); 7.0802 (9.1); 7.0603 (6.0); 4.6046 (3.1); 4.5662 (3.5); 4.2941 (4.0); 4.2801 (6.9); 4.2665 (4.6); 3.9841 (3.6); 3.9457 (3.2); 3.9084 (3.6); 3.8978 (4.5); 3.8929 (5.2); 3.8845 (2.5); 3.5524 (1.8); 3.5418 (1.8); 3.3331 (327.8); 3.1846 (2.2); 2.6856 (1.6); 2.5808 (1.5); 2.5390 (3.6); 2.5256 (88.4); 2.5211 (193.0); 2.5164 (270.1); 2.5118 (187.0); 2.5072 (84.0); 2.4548 (2.4); 2.4435 (2.6); 2.4138 (2.7); 2.4037 (3.1); 2.3574 (2.2); 2.3389 (2.8); 2.3014 (24.0); 2.2819 (2.2); 2.2672 (1.9); 2.2569 (2.3); 2.2425 (2.1); 2.0661 (2.9); 2.0457 (3.0); 2.0273 (3.0); 2.0062 (2.0); 1.5494 (1.5); 0.0156 (2.3) I.1-146:1H NMR (400.0MHz, CDCl3): δ= 7.5215 (0.9); 7.3826 (14.6); 7.3724 (0.5); 7.3621 (16.5); 7.2626 (183.5); 7.2570 (12.6); 7.1286 (1.1); 7.1191 (1.6); 7.1130 (1.6); 7.1039 (3.7); 7.0913 (2.6); 7.0888 (2.5); 7.0852 (2.9); 7.0772 (3.8); 7.0703 (1.8); 7.0651 (2.0); 7.0609 (4.2); 7.0573 (7.8); 7.0498 (11.2); 7.0472 (6.9); 7.0411 (10.1); 7.0338 (4.0); 7.0306 (6.0); 7.0272 (7.6); 7.0219 (7.4); 7.0127 (1.0); 7.0067 (6.4); 7.0015 (6.1); 5.4813 (2.4); 5.2999 (8.8); 4.8500 (4.8); 4.8464 (4.7); 4.8114 (5.4); 4.8076 (5.2); 4.2343 (7.0); 4.1957 (6.2); 3.9418 (1.1); 3.9306 (2.3); 3.9198 (2.9); 3.9095 (3.3); 3.8996 (2.9); 3.8888 (2.4); 3.8779 (1.1); 3.5433 (0.6); 3.5256 (1.3); 3.5092 (2.9); 3.4914 (5.9); 3.4761 (6.0); 3.4736 (6.2); 3.4715 (5.8); 3.4563 (5.8); 3.4390 (3.0); 3.4219 (1.3); 3.4049 (0.6); 2.7820 (8.4); 2.7644 (16.0); 2.7470 (7.1); 2.5969 (5.0); 2.5860 (5.0); 2.5607 (5.7); 2.5498 (5.6); 2.5240 (1.0); 2.5039 (1.3); 2.5005 (1.2); 2.4805 (3.6); 2.4609 (3.3); 2.4574 (3.1); 2.4380 (3.1); 2.4276 (3.6); 2.4129 (4.2); 2.4035 (5.0); 2.3890 (5.0); 2.3847 (1.8); 2.3701 (1.4); 2.3605 (2.3); 2.3462 (2.2); 2.2757 (2.0); 2.2565 (3.1); 2.2518 (1.9); 2.2430 (2.4); 2.2375 (2.0); 2.2325 (2.6); 2.2240 (3.3); 2.2190 (2.2); 2.2136 (1.5); 2.2048 (2.1); 2.1997 (2.6); 2.1808 (1.4); 2.1412 (6.3); 2.1189 (6.2); 2.1050 (5.4); 2.0827 (5.3); 1.8164 (1.6); 1.8051 (1.8); 1.8023 (2.0); 1.7913 (2.3); 1.7818 (2.2); 1.7785 (1.9); 1.7724 (1.8); 1.7692 (2.2); 1.7580 (2.0); 1.7488 (1.5); 1.7457 (1.4); 1.7342 (1.2); 0.0080 (1.5); -0.0002 (51.8); -0.0085 (1.4) I.1-147:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1493 (1.8); 7.1289 (7.4); 7.1156 (8.2); 7.0949 (1.9); 4.6625 (5.2); 4.6584 (7.2); 4.6566 (7.6); 4.6527 (5.5); 4.6189 (2.4); 4.0542 (2.3); 4.0160 (2.0); 3.7227 (0.7); 3.7121 (1.0); 3.7017 (1.2); 3.6913 (1.0); 3.6808 (0.8); 3.5666 (2.3); 3.5605 (5.0); 3.5544 (2.3); 3.3988 (0.8); 3.3677 (137.6); 2.8045 (1.5); 2.7943 (1.5); 2.7645 (1.9); 2.7543 (1.9); 2.6716 (0.5); 2.5249 (1.0); 2.5202 (1.6); 2.5116 (30.6); 2.5071 (65.4); 2.5025 (89.4); 2.4980 (63.0); 2.4934 (29.0); 2.4784 (2.6); 2.4695 (0.6); 2.4603 (2.0); 2.4384 (2.2); 2.4154 (1.2); 2.3971 (1.0); 2.3919 (0.9); 2.3735 (0.8); 2.3293 (0.6); 2.2868 (1.2); 2.2779 (16.0); 2.2625 (1.4); 2.2493 (1.4); 2.2325 (0.5); 2.2208 (0.8); 2.2079 (0.9); 2.1667 (0.6); 2.1478 (0.8); 2.1350 (0.7); 2.1288 (0.6); 2.1227 (0.6); 2.1165 (1.0); 2.1108 (0.6); 2.0969 (0.6); 2.0914 (0.7); 2.0721 (0.5); 1.7081 (0.7); 1.6967 (0.9); 1.6857 (0.8); 1.6764 (0.8); 1.6648 (0.8); 1.6536 (0.5); -0.0002 (3.3) I.1-148:1H NMR (400.1 MHz, i.e6-DMSO): δ= 12.5995 (0.3); 12.5697 (0.4); 12.5511 (0.5); 12.5463 (0.4); 12.5223 (0.5); 12.4648 (0.4); 12.4379 (0.4); 7.3853 (1.4); 7.3652 (3.4); 7.3414 (3.4); 7.3197 (1.9); 7.2747 (0.7); 7.2564 (0.8); 7.2304 (1.0); 7.2122 (2.2); 7.1924 (3.7); 7.1797 (4.0); 7.1592 (2.1); 7.0754 (3.3); 7.0579 (5.0); 7.0392 (2.5); 4.7722 (3.3); 4.7485 (10.2); 4.7243 (16.0); 4.7001 (4.0); 4.6850 (6.7); 4.2406 (6.5); 4.2007 (5.7); 3.8510 (1.0); 3.8408 (2.0); 3.8308 (2.8); 3.8203 (3.4); 3.8107 (2.9); 3.7991 (2.2); 3.7910 (1.1); 3.5879 (0.4); 3.5774 (0.3); 3.5542 (0.6); 3.5450 (0.4); 3.3775 (42.3); 3.3101 (2.3); 3.2937 (1.6); 3.2848 (1.2); 3.2669 (1.0); 3.2543 (0.8); 3.2122 (0.5); 3.1963 (0.4); 3.1810 (0.4); 3.1719 (6.6); 3.1700 (6.3); 3.1686 (7.7); 2.8345 (0.5); 2.8151 (1.0); 2.8059 (3.6); 2.7964 (4.0); 2.7670 (4.4); 2.7575 (4.2); 2.6696 (1.4); 2.5478 (1.2); 2.5400 (0.7); 2.5040 (226.0); 2.5006 (244.5); 2.4646 (5.8); 2.4479 (5.0); 2.4250 (5.2); 2.4019 (3.8); 2.3827 (3.7); 2.3620 (2.5); 2.3271 (1.7); 2.3079 (2.2); 2.2959 (2.4); 2.2843 (3.2); 2.2715 (3.5); 2.2556 (0.8); 2.2421 (2.2); 2.2305 (3.1); 2.2099 (2.5); 2.1972 (2.0); 2.1779 (2.8); 2.1658 (1.2); 2.1571 (2.0); 2.1347 (0.8); 2.0751 (1.1); 2.0718 (1.2); 1.7679 (1.2); 1.7588 (2.3); 1.7472 (2.3); 1.7371 (2.7); 1.7282 (2.6); 1.7162 (2.1); 1.7045 (1.7); 1.6931 (1.0); 1.3458 (0.3); 1.3280 (0.6); 1.3112 (0.4); 1.2354 (0.3); 0.0082 (1.1); 0.0033 (24.6); 0.0013 (23.4) I.1-149:1H NMR (400.0MHz, d6-DMSO): δ= 8.4636 (0.7); 8.4502 (1.2); 8.4356 (0.6); 7.3295 (1.5); 7.3140 (2.3); 7.3103 (3.7); 7.2986 (1.2); 7.2932 (3.6); 7.2466 (1.7); 7.2332 (6.2); 7.2133 (4.0); 7.1397 (2.1); 7.1196 (7.0); 7.1023 (7.7); 7.0817 (2.3); 4.6713 (2.0); 4.6331 (2.2); 4.2544 (2.2); 4.2455 (2.5); 4.2400 (2.5); 4.2311 (2.3); 4.0080 (2.3); 3.9700 (2.0); 3.7475 (0.7); 3.7366 (1.0); 3.7260 (1.0); 3.7162 (1.0); 3.7055 (0.7); 3.3162 (153.6); 3.2651 (0.6); 3.1682 (0.6); 2.6741 (0.5); 2.6695 (0.7); 2.6646 (0.5); 2.5909 (1.3); 2.5799 (1.3); 2.5561 (1.6); 2.5451 (1.5); 2.5228 (1.8); 2.5180 (2.6); 2.5094 (45.4); 2.5049 (98.1); 2.5003 (136.7); 2.4957 (96.1); 2.4912 (43.6); 2.3661 (0.6); 2.3467 (1.2); 2.3272 (1.8); 2.3049 (1.0); 2.2744 (16.0); 2.2577 (1.2); 2.2475 (1.3); 2.2337 (1.3); 2.2158 (0.7); 2.2098 (1.8); 2.1873 (1.7); 2.1750 (1.5); 2.1524 (1.4); 2.0640 (0.8); 2.0519 (0.6); 2.0404 (0.7); 2.0328 (0.9); 2.0085 (0.8); 1.7348 (0.6); 1.7242 (0.9); 1.7134 (0.7); 1.7020 (0.7); 1.6923 (0.7); -0.0002 (0.5) I.1-150:1H NMR (400.1 MHz, i.e6-DMSO): δ= 11.4828 (0.9); 7.1786 (0.3); 7.0645 (0.4); 4.7372 (0.5); 4.6976 (0.6); 4.2484 (0.6); 4.2087 (0.5); 3.4007 (1.3); 2.7735 (16.0); 2.7376 (0.4); 2.7275 (0.4); 2.6998 (0.5); 2.6897 (0.5); 2.5098 (2.3); 2.5053 (5.1); 2.5007 (7.2); 2.4961 (5.3); 2.4916 (2.5); 2.4232 (0.5); 2.4012 (0.5); 2.3973 (0.4); 2.3857 (0.4); 2.3769 (0.3); 2.3637 (0.4); 2.2811 (0.4); 2.2687 (0.4) I.1-151:1H NMR (400.1 MHz, CDCl3): δ= 7.2638 (13.5); 7.0981 (0.6); 7.0862 (0.4); 7.0826 (0.4); 7.0795 (0.5); 7.0757 (0.6); 7.0731 (0.6); 7.0631 (0.4); 7.0566 (1.8); 7.0497 (1.8); 7.0462 (1.2); 7.0411 (1.9); 7.0329 (0.7); 7.0303 (0.7); 6.1081 (0.4); 4.8632 (0.9); 4.8597 (0.9); 4.8244 (1.0); 4.8208 (1.0); 4.2666 (1.3); 4.2278 (1.1); 3.9706 (0.4); 3.9601 (0.5); 3.9499 (0.7); 3.9398 (0.5); 3.9292 (0.4); 3.7080 (16.0); 3.5190 (0.5); 3.5143 (0.5); 3.5102 (0.3); 3.5019 (1.2); 3.4994 (1.1); 3.4947 (0.5); 3.4892 (1.2); 3.4862 (1.3); 3.4782 (0.3); 3.4741 (0.5); 3.4697 (0.5); 2.6137 (0.9); 2.6027 (0.9); 2.5775 (1.1); 2.5664 (1.1); 2.5387 (2.0); 2.5306 (0.8); 2.5240 (2.2); 2.5179 (0.5); 2.5091 (2.4); 2.4888 (0.6); 2.4845 (0.5); 2.4657 (0.6); 2.4400 (0.6); 2.4254 (0.7); 2.4157 (0.8); 2.4013 (0.9); 2.3972 (0.4); 2.3728 (0.4); 2.3586 (0.5); 2.3027 (0.4); 2.2838 (0.7); 2.2787 (0.5); 2.2703 (0.6); 2.2650 (0.6); 2.2595 (0.6); 2.2513 (0.8); 2.2461 (0.6); 2.2409 (0.4); 2.2323 (0.5); 2.2269 (0.6); 2.2081 (0.3); 2.1913 (1.2); 2.1695 (1.1); 2.1551 (1.0); 2.1332 (1.0); 1.8559 (0.3); 1.8536 (0.4); 1.8427 (0.4); 1.8326 (0.4); 1.8297 (0.4); 1.8234 (0.3); 1.8207 (0.4); 1.8184 (0.3); 1.8097 (0.4) I.1-152:1H NMR (400.1 MHz, CDCl3): δ= 7.3818 (1.8); 7.3778 (2.9); 7.3735 (0.8); 7.3587 (4.4); 7.3528 (0.6); 7.3104 (2.3); 7.3056 (0.7); 7.2922 (4.4); 7.2721 (2.5); 7.2594 (42.6); 7.2336 (1.6); 7.2203 (0.6); 7.2153 (2.2); 7.2103 (0.4); 7.1967 (0.6); 7.1313 (1.0); 7.1101 (8.8); 7.1047 (9.6); 7.0894 (0.6); 7.0836 (1.1); 4.8593 (2.1); 4.8215 (2.3); 4.2300 (3.0); 4.2131 (6.4); 4.1961 (3.3); 4.0170 (2.2); 3.9791 (2.0); 3.8450 (0.4); 3.8342 (0.7); 3.8238 (1.0); 3.8131 (1.2); 3.8027 (1.0); 3.7922 (0.8); 3.7818 (0.4); 3.1055 (3.4); 3.0885 (6.6); 3.0716 (3.2); 2.6202 (1.4); 2.6099 (1.4); 2.5814 (1.8); 2.5712 (1.8); 2.5398 (0.3); 2.5212 (0.4); 2.5158 (0.4); 2.4970 (1.1); 2.4784 (1.0); 2.4733 (0.9); 2.4546 (0.9); 2.4314 (0.9); 2.4171 (1.0); 2.4070 (1.2); 2.3927 (1.2); 2.3747 (0.4); 2.3642 (0.6); 2.3500 (0.6); 2.3250 (16.0); 2.3149 (2.1); 2.2927 (1.8); 2.2761 (1.4); 2.2540 (1.4); 2.2483 (0.5); 2.2288 (0.8); 2.2242 (0.4); 2.2154 (0.5); 2.2096 (0.5); 2.2045 (0.6); 2.1962 (0.9); 2.1914 (0.5); 2.1854 (0.3); 2.1770 (0.5); 2.1717 (0.7); 2.1526 (0.3); 1.8112 (0.4); 1.7981 (0.6); 1.7865 (0.8); 1.7768 (0.7); 1.7632 (0.6); 1.7538 (0.7); 1.7423 (0.4); 1.7290 (0.3); 1.5523 (12.1); 0.0080 (0.5); 0.0006 (15.6); 0.0000 (15.6) I.1-153:1H NMR (400.0 MHz, CDCl3): δ= 7.2618 (32.7); 7.1138 (28.9); 6.7447 (3.0); 6.7251 (3.8); 6.6371 (2.7); 6.6333 (3.1); 6.5946 (1.9); 6.5903 (1.6); 6.5749 (1.5); 6.5706 (1.3); 5.9355 (2.7); 5.9320 (8.8); 5.9298 (9.0); 5.9262 (2.7); 5.3317 (0.6); 5.2982 (3.2); 4.7148 (1.8); 4.6773 (2.0); 4.1062 (1.8); 4.0686 (1.6); 3.9451 (0.6); 3.9348 (0.7); 3.9246 (1.1); 3.9143 (0.7); 3.9040 (0.6); 3.4499 (0.7); 3.4324 (1.2); 3.4174 (1.2); 3.4029 (1.2); 3.3883 (1.2); 3.3711 (0.7); 2.6922 (2.0); 2.6749 (4.1); 2.6576 (1.8); 2.4941 (1.4); 2.4827 (1.2); 2.4683 (0.9); 2.4582 (1.4); 2.4466 (2.1); 2.4260 (0.7); 2.4149 (0.8); 2.4006 (1.0); 2.3907 (1.1); 2.3766 (1.1); 2.3480 (0.6); 2.3338 (0.7); 2.3228 (16.0); 2.2088 (0.7); 2.1956 (0.5); 2.1847 (0.7); 2.1763 (0.8); 2.1715 (0.5); 2.1569 (0.5); 2.1520 (0.7); 2.0677 (1.5); 2.0464 (1.5); 2.0317 (1.3); 2.0104 (1.3); 1.7419 (0.6); 1.7320 (0.6); 1.7192 (0.6); 1.7087 (0.5); -0.0002 (9.8) I.1-154:1H NMR (400.1 MHz, i.e6-DMSO): δ= 12.3544 (0.4); 12.3433 (0.5); 12.3055 (0.6); 12.2962 (0.7); 12.2442 (0.9); 12.2247 (0.9); 12.2081 (0.8); 12.1752 (0.7); 12.1614 (0.5); 12.1562 (0.5); 12.1320 (0.4); 12.1302 (0.4); 12.1145 (0.4); 6.8506 (0.7); 6.8417 (0.7); 6.8341 (3.0); 6.8258 (0.7); 6.8173 (0.9); 6.8114 (0.8); 6.8023 (0.7); 6.7951 (2.7); 6.7786 (0.8); 5.7931 (4.3); 5.7540 (4.1); 5.6421 (0.4); 5.6308 (0.7); 5.6202 (0.3); 5.5905 (0.8); 5.5851 (0.8); 5.5812 (1.3); 5.5770 (0.8); 5.5716 (0.9); 5.5676 (0.5); 4.8167 (1.1); 4.8029 (1.4); 4.7982 (3.0); 4.7845 (3.2); 4.7803 (3.2); 4.7667 (3.1); 4.7620 (1.6); 4.7481 (1.2); 3.5778 (1.6); 3.4591 (0.3); 3.4076 (1.8); 3.3979 (0.7); 3.3589 (1.9); 3.3063 (431.0); 3.2145 (0.8); 3.2110 (0.8); 3.1747 (0.6); 3.1631 (0.7); 3.0280 (1.6); 3.0152 (1.6); 3.0018 (3.3); 2.9976 (2.1); 2.9924 (2.2); 2.9882 (3.3); 2.7250 (1.0); 2.7135 (2.1); 2.6998 (2.4); 2.6727 (9.1); 2.6693 (3.7); 2.6644 (2.4); 2.6590 (8.2); 2.6466 (8.4); 2.6279 (7.9); 2.6056 (2.4); 2.5870 (2.5); 2.5793 (1.0); 2.5564 (2.5); 2.5510 (0.9); 2.5461 (0.5); 2.5355 (4.2); 2.5226 (4.2); 2.5177 (6.5); 2.5092 (141.5); 2.5046 (308.9); 2.5001 (435.5); 2.4955 (310.0); 2.4909 (145.8); 2.4756 (7.2); 2.4678 (2.0); 2.4547 (1.3); 2.4493 (0.8); 2.4444 (1.5); 2.4319 (1.2); 2.3913 (13.1); 2.3849 (16.0); 2.3511 (1.7); 2.3386 (1.7); 2.3318 (2.5); 2.3272 (3.7); 2.3215 (3.4); 2.3106 (1.5); 2.3072 (2.0); 2.3023 (2.0); 2.2972 (2.1); 2.2897 (2.0); 2.2840 (1.4); 2.2795 (1.5); 2.2667 (1.3); 2.0846 (0.3); 2.0710 (1.5); 1.9211 (1.4); 1.9021 (1.6); 1.8980 (2.9); 1.8897 (1.3); 1.8791 (2.8); 1.8751 (1.5); 1.8709 (1.5); 1.8666 (2.3); 1.8562 (1.2); 1.8477 (2.4); 1.8437 (1.2); 1.8248 (1.1); 1.5443 (0.6); 0.0119 (0.6); 0.0082 (2.1) I.1-155:1H NMR (400.0MHz, d6-DMSO): δ= 8.2423 (0.5); 8.2285 (1.0); 8.2147 (0.5); 7.5641 (4.0); 7.3560 (0.8); 7.3402 (0.5); 7.3342 (0.8); 7.2872 (4.2); 7.2857 (4.3); 7.1856 (0.8); 7.1818 (0.8); 7.1727 (0.8); 7.1693 (0.8); 7.1654 (0.5); 7.0713 (0.8); 7.0553 (1.0); 7.0357 (0.5); 4.7306 (1.2); 4.6903 (1.4); 4.2163 (1.5); 4.1770 (1.3); 4.0842 (1.9); 4.0659 (7.0); 4.0568 (2.2); 4.0479 (7.0); 4.0437 (2.2); 4.0297 (1.9); 3.8004 (0.7); 3.7902 (0.9); 3.7804 (0.8); 3.7697 (0.5); 3.4701 (11.9); 3.1681 (0.6); 2.5323 (1.1); 2.5207 (1.6); 2.5104 (17.6); 2.5059 (39.0); 2.5012 (54.9); 2.4966 (39.0); 2.4920 (17.1); 2.3446 (0.9); 2.3235 (1.0); 2.3028 (0.7); 2.2754 (0.7); 2.2623 (0.8); 2.2514 (1.0); 2.2384 (1.0); 2.2176 (1.4); 2.2096 (0.6); 2.1961 (1.7); 2.1827 (1.1); 2.1611 (1.1); 2.1234 (0.6); 2.0995 (0.6); 2.0919 (0.8); 2.0732 (0.5); 2.0679 (0.6); 1.7485 (0.6); 1.7384 (0.6); 1.7274 (0.6); 1.7169 (0.6); 1.3358 (7.1); 1.3177 (16.0); 1.2995 (7.0); -0.0002 (2.5) I.1-156:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1470 (2.1); 7.1269 (6.1); 7.1058 (6.7); 7.0854 (2.3); 5.7717 (0.9); 5.7628 (0.5); 5.7458 (1.4); 5.7288 (1.5); 5.7197 (0.6); 5.7119 (0.5); 5.7030 (1.1); 5.6863 (0.5); 5.1026 (0.6); 5.0986 (1.6); 5.0941 (1.8); 5.0901 (0.8); 5.0595 (0.6); 5.0554 (1.5); 5.0510 (2.4); 5.0483 (2.2); 5.0437 (1.5); 5.0256 (0.7); 5.0227 (1.6); 5.0202 (1.2); 5.0180 (1.3); 5.0150 (0.6); 4.6553 (1.8); 4.6171 (2.1); 4.0484 (2.3); 4.0433 (3.2); 4.0266 (6.2); 4.0102 (5.0); 3.7143 (0.7); 3.7038 (1.0); 3.6934 (1.1); 3.6831 (1.0); 3.6727 (0.8); 3.4887 (14.9); 2.7377 (1.4); 2.7276 (1.4); 2.6982 (1.8); 2.6881 (1.7); 2.5203 (0.6); 2.5116 (11.0); 2.5072 (23.2); 2.5026 (31.5); 2.4981 (22.2); 2.4936 (10.2); 2.4285 (2.0); 2.4163 (0.6); 2.4067 (1.9); 2.3893 (1.9); 2.3743 (0.9); 2.3673 (2.1); 2.3509 (0.8); 2.3079 (0.7); 2.3047 (1.1); 2.3014 (0.7); 2.2913 (2.0); 2.2879 (3.7); 2.2849 (2.9); 2.2759 (16.0); 2.2617 (1.6); 2.2549 (1.3); 2.2510 (1.0); 2.2478 (1.4); 2.2308 (0.6); 2.2197 (0.8); 2.2063 (0.8); 2.1414 (0.7); 2.1288 (0.6); 2.1229 (0.5); 2.1166 (0.6); 2.1103 (0.8); 2.1044 (0.5); 2.0909 (0.5); 2.0852 (0.6); 1.7031 (0.6); 1.6917 (0.8); 1.6807 (0.7); 1.6712 (0.7); 1.6674 (0.5); 1.6598 (0.8); -0.0002 (2.7) I.1-157:1H NMR (400.0MHz, d6-DMSO): δ= 9.0051 (2.4); 8.6554 (0.8); 8.6356 (0.8); 7.4178 (2.3); 7.1407 (1.9); 7.1208 (4.2); 7.0920 (4.5); 7.0717 (1.9); 4.6444 (1.2); 4.6060 (1.7); 4.5919 (0.6); 4.5822 (0.5); 3.9486 (1.3); 3.9107 (1.2); 3.6437 (0.7); 3.6273 (16.0); 3.6125 (0.6); 3.4337 (16.8); 3.1854 (0.5); 3.1677 (2.3); 3.1520 (0.6); 3.1280 (1.0); 3.1148 (0.9); 3.0484 (0.9); 3.0244 (0.9); 3.0107 (0.6); 2.9871 (0.6); 2.6697 (0.5); 2.5185 (2.2); 2.5098 (30.0); 2.5053 (63.5); 2.5006 (88.5); 2.4960 (61.1); 2.4914 (27.4); 2.4766 (1.2); 2.3368 (0.5); 2.3274 (0.6); 2.3180 (0.9); 2.2959 (0.8); 2.2752 (11.0); 2.2456 (0.6); 2.2325 (0.6); 2.2217 (0.8); 2.2071 (1.3); 2.1838 (1.0); 2.1719 (0.8); 2.1666 (0.6); 2.1494 (0.7); 1.9521 (0.6); 0.0080 (0.6); -0.0002 (19.6); -0.0086 (0.6) I.1-158:1H NMR (400.0MHz, d6-DMSO): δ= 7.2324 (0.9); 7.2136 (2.2); 7.1949 (1.4); 7.0826 (1.2); 7.0636 (0.9); 7.0296 (2.0); 7.0167 (1.2); 6.9969 (1.0); 4.6859 (1.3); 4.6476 (1.5); 4.0476 (1.5); 4.0093 (1.4); 3.9639 (0.8); 3.7124 (0.6); 3.7022 (0.8); 3.6927 (0.8); 3.6894 (0.8); 3.6798 (0.8); 3.6698 (0.7); 3.5535 (0.6); 3.1693 (16.0); 2.6925 (1.1); 2.6829 (1.1); 2.6529 (1.3); 2.6433 (1.3); 2.5107 (3.4); 2.5061 (7.3); 2.5015 (10.1); 2.4969 (7.0); 2.4923 (3.1); 2.4031 (0.8); 2.3848 (0.6); 2.3798 (0.6); 2.3616 (0.6); 2.3214 (1.5); 2.2981 (2.1); 2.2857 (11.3); 2.2733 (1.1); 2.2589 (1.9); 2.2315 (0.6); 2.2183 (0.6); 2.1654 (0.5); 2.1344 (0.6); 1.7095 (0.6); 1.6777 (0.6); - 0.0002 (2.4) I.1-159:1H NMR (400.1 MHz, d6-DMSO): δ= 7.4065 (2.2); 7.3908 (3.0); 7.3865 (4.4); 7.3713 (4.6); 7.3672 (3.6); 7.3515 (3.1); 7.2071 (4.4); 7.1160 (2.1); 7.1099 (2.5); 7.0934 (3.8); 7.0883 (4.5); 7.0755 (16.0); 7.0681 (3.1); 7.0571 (9.2); 7.0314 (3.3); 7.0273 (3.8); 6.9439 (4.6); 4.6331 (5.9); 4.5938 (6.9); 4.1675 (6.9); 4.1283 (5.9); 3.8352 (0.9); 3.8247 (2.0); 3.8141 (2.8); 3.8038 (3.2); 3.7935 (2.9); 3.7831 (2.2); 3.7726 (1.1); 2.8262 (3.7); 2.8159 (3.8); 2.7867 (4.6); 2.7764 (4.6); 2.6698 (0.3); 2.5232 (0.4); 2.5185 (0.7); 2.5098 (18.0); 2.5053 (40.8); 2.5007 (58.1); 2.4961 (43.1); 2.4917 (21.1); 2.4749 (5.0); 2.4526 (4.9); 2.4353 (4.1); 2.4248 (1.8); 2.4131 (4.0); 2.4067 (3.8); 2.3880 (2.9); 2.3836 (2.8); 2.3650 (2.5); 2.3322 (0.3); 2.3276 (0.5); 2.3189 (2.3); 2.3055 (2.6); 2.2946 (3.5); 2.2813 (3.5); 2.2641 (1.1); 2.2528 (2.0); 2.2401 (2.2); 2.2128 (1.4); 2.1940 (2.2); 2.1891 (1.3); 2.1815 (1.7); 2.1751 (1.5); 2.1698 (1.8); 2.1626 (2.6); 2.1577 (1.7); 2.1510 (1.1); 2.1431 (1.6); 2.1383 (1.9); 2.1191 (0.9); 2.0710 (0.7); 1.7437 (1.1); 1.7320 (1.8); 1.7205 (2.4); 1.7097 (2.1); 1.7003 (2.2); 1.6888 (2.2); 1.6774 (1.5); 1.6647 (1.0); 0.0082 (0.4) I.1-160:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.9248 (0.5); 7.9177 (4.2); 7.9129 (1.3); 7.9005 (1.3); 7.8955 (4.4); 7.1255 (1.3); 7.1049 (5.4); 7.0924 (5.8); 7.0718 (1.4); 7.0558 (0.5); 7.0487 (4.2); 7.0438 (1.3); 7.0314 (1.2); 7.0265 (4.0); 4.6448 (1.4); 4.6067 (1.6); 4.3549 (0.8); 4.3446 (2.0); 4.3352 (2.1); 4.3260 (1.1); 4.2461 (2.2); 4.2353 (2.8); 4.2243 (1.4); 4.0467 (1.6); 4.0083 (1.4); 3.8143 (16.0); 3.7137 (0.7); 3.7034 (0.8); 3.6930 (0.7); 3.6829 (0.5); 3.3260 (190.0); 2.7839 (0.9); 2.7738 (1.0); 2.7442 (1.2); 2.7340 (1.2); 2.5102 (25.0); 2.5058 (52.5); 2.5013 (71.9); 2.4968 (51.1); 2.4925 (23.7); 2.4832 (1.9); 2.4612 (1.3); 2.4432 (1.1); 2.4213 (1.1); 2.3840 (0.8); 2.3665 (0.6); 2.3611 (0.6); 2.3431 (0.6); 2.2587 (11.3); 2.2440 (0.9); 2.2302 (0.9); 2.2023 (0.5); 2.1889 (0.5); 2.1325 (0.5); 2.1013 (0.6); 1.7010 (0.6); 1.6900 (0.5); 1.6808 (0.5); 1.6689 (0.5); -0.0002 (1.7) I.1-161:1H NMR (400.1 MHz, d6-DMSO): δ= 11.7696 (3.0); 7.3869 (0.4); 7.3831 (0.4); 7.3665 (0.8); 7.3625 (0.9); 7.3565 (0.5); 7.3468 (0.6); 7.3406 (0.9); 7.3365 (0.8); 7.3202 (0.5); 7.3164 (0.5); 7.2145 (0.5); 7.2108 (0.6); 7.2017 (0.5); 7.1979 (0.7); 7.1945 (1.0); 7.1910 (1.0); 7.1818 (0.9); 7.1785 (1.0); 7.1745 (0.6); 7.1705 (0.6); 7.1615 (0.6); 7.1581 (0.6); 7.0835 (1.0); 7.0674 (1.3); 7.0643 (1.3); 7.0480 (0.7); 4.7358 (1.5); 4.6962 (1.8); 4.2472 (1.9); 4.2073 (1.6); 3.8457 (0.6); 3.8353 (0.9); 3.8250 (1.0); 3.8148 (0.9); 3.8047 (0.6); 3.3984 (16.0); 3.3400 (0.4); 3.1687 (6.8); 2.9508 (0.4); 2.9367 (1.0); 2.9344 (0.8); 2.9261 (0.6); 2.9187 (1.7); 2.9129 (0.6); 2.9067 (0.7); 2.9026 (1.0); 2.8996 (0.6); 2.8871 (0.5); 2.7563 (1.3); 2.7458 (1.3); 2.7184 (1.6); 2.7080 (1.6); 2.6698 (0.4); 2.5401 (0.5); 2.5233 (0.8); 2.5185 (1.2); 2.5099 (19.4); 2.5053 (42.5); 2.5007 (59.8); 2.4961 (43.2); 2.4915 (20.3); 2.4465 (1.9); 2.4249 (2.1); 2.4087 (1.6); 2.4033 (1.2); 2.3866 (1.9); 2.3627 (0.7); 2.3277 (0.4); 2.3030 (0.7); 2.2908 (0.8); 2.2788 (1.2); 2.2667 (1.2); 2.2616 (0.5); 2.2371 (0.8); 2.2252 (1.0); 2.2067 (0.8); 2.1950 (0.6); 2.1877 (0.5); 2.1825 (0.5); 2.1758 (1.0); 2.1712 (0.5); 2.1560 (0.5); 2.1516 (0.6); 2.0721 (0.4); 1.7893 (0.4); 1.7803 (0.7); 1.7687 (0.7); 1.7587 (0.8); 1.7504 (0.8); 1.7467 (0.5); 1.7388 (0.6); 1.7259 (0.5); 1.0795 (0.9); 1.0683 (8.4); 1.0642 (3.5); 1.0541 (3.5); 1.0497 (4.4); 1.0447 (2.3) I.1-162:1H NMR (400.0 MHz, i.e6-DMSO): δ= 11.8115 (2.9); 7.0842 (0.8); 7.0665 (1.7); 7.0473 (1.1); 6.9675 (1.1); 6.9643 (1.2); 6.9471 (1.8); 6.9303 (0.8); 6.9271 (0.8); 4.6937 (1.8); 4.6542 (2.1); 4.1785 (2.3); 4.1391 (2.0); 3.9644 (0.9); 3.8139 (0.8); 3.8034 (1.1); 3.7929 (1.3); 3.7827 (1.1); 3.7725 (0.8); 3.4807 (16.0); 3.2125 (36.5); 3.1689 (6.1); 2.7366 (1.7); 2.7262 (1.8); 2.6983 (2.2); 2.6879 (2.0); 2.5236 (1.2); 2.5189 (1.6); 2.5103 (22.0); 2.5057 (46.8); 2.5010 (64.2); 2.4964 (44.9); 2.4918 (20.1); 2.4242 (2.3); 2.4022 (2.7); 2.3858 (3.0); 2.3640 (2.8); 2.3434 (1.0); 2.2892 (1.0); 2.2767 (1.3); 2.2622 (10.2); 2.2575 (10.0); 2.2232 (0.9); 2.2118 (1.0); 2.1982 (0.7); 2.1795 (1.0); 2.1676 (0.7); 2.1603 (0.6); 2.1554 (0.7); 2.1482 (1.2); 2.1435 (0.6); 2.1284 (0.6); 2.1239 (0.8); 1.7645 (0.8); 1.7533 (0.9); 1.7430 (0.9); 1.7336 (1.0); 1.7222 (0.8); 1.7105 (0.6); -0.0002 (8.7) I.1-163:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.5739 (0.6); 7.5701 (0.6); 7.5538 (0.7); 7.5501 (0.6); 7.3639 (0.7); 7.3443 (1.3); 7.3245 (0.8); 7.2132 (0.6); 7.2095 (0.6); 4.6726 (0.6); 4.6315 (0.7); 4.2824 (0.7); 4.2412 (0.5); 3.5781 (16.0); 3.1684 (0.7); 2.5307 (0.6); 2.5233 (0.8); 2.5186 (1.2); 2.5100 (16.6); 2.5054 (35.6); 2.5008 (48.4); 2.4961 (33.4); 2.4915 (15.0); 2.2233 (0.8); 2.2011 (0.5); 2.1868 (0.5); -0.0002 (3.0) I.1-164:1H NMR (400.1 MHz, d6-DMSO): δ= 11.4616 (1.0); 7.4066 (0.5); 7.3796 (0.5); 4.6068 (0.5); 4.5678 (0.6); 4.1463 (0.7); 4.1072 (0.6); 3.7859 (0.3); 3.4370 (1.1); 2.7761 (16.0); 2.7187 (0.4); 2.7082 (0.4); 2.6809 (0.5); 2.6704 (0.5); 2.5102 (2.0); 2.5057 (4.4); 2.5011 (6.2); 2.4965 (4.6); 2.4921 (2.2); 2.3880 (0.4); 2.3638 (0.7); 2.3416 (0.5); 2.3259 (0.4); 2.3035 (0.5); 2.2907 (0.4); 2.2770 (0.4) I.1-166:1H NMR (400.0MHz, d6-DMSO): δ= 11.8114 (5.2); 7.3902 (2.4); 7.3711 (6.4); 7.3531 (7.1); 7.3520 (7.4); 7.3458 (3.5); 7.3416 (6.2); 7.3369 (5.0); 7.3259 (1.3); 7.3207 (2.2); 7.3169 (1.5); 7.2910 (4.4); 7.2868 (6.8); 7.2833 (3.8); 7.2019 (2.7); 7.1980 (4.8); 7.1943 (2.6); 7.1840 (2.2); 7.1799 (3.8); 7.1762 (2.1); 4.6368 (4.2); 4.5976 (4.9); 4.1406 (4.8); 4.1013 (4.2); 3.9643 (0.8); 3.8345 (0.7); 3.8238 (1.5); 3.8131 (2.1); 3.8027 (2.4); 3.7929 (2.1); 3.7823 (1.6); 3.7718 (0.7); 3.3904 (46.2); 3.3395 (0.8); 3.2658 (0.6); 3.2163 (64.1); 3.1683 (16.0); 3.1657 (0.5); 2.7425 (3.1); 2.7317 (3.2); 2.7042 (3.8); 2.6934 (3.6); 2.6743 (0.8); 2.6696 (1.1); 2.6650 (0.8); 2.5546 (0.6); 2.5500 (1.1); 2.5453 (1.1); 2.5399 (1.3); 2.5337 (0.8); 2.5288 (1.0); 2.5232 (2.7); 2.5184 (3.8); 2.5098 (58.7); 2.5052 (126.6); 2.5005 (175.4); 2.4959 (123.5); 2.4913 (55.9); 2.4398 (1.1); 2.4217 (1.2); 2.4174 (1.2); 2.3985 (2.7); 2.3911 (4.1); 2.3797 (2.3); 2.3755 (2.3); 2.3692 (4.1); 2.3529 (3.8); 2.3310 (3.7); 2.3275 (1.7); 2.3195 (2.0); 2.3063 (2.2); 2.2954 (2.8); 2.2822 (2.7); 2.2779 (1.2); 2.2646 (0.9); 2.2535 (1.5); 2.2407 (1.5); 2.2020 (1.1); 2.1829 (1.7); 2.1781 (1.0); 2.1704 (1.3); 2.1637 (1.1); 2.1587 (1.4); 2.1512 (2.0); 2.1464 (1.2); 2.1397 (0.8); 2.1318 (1.2); 2.1270 (1.4); 2.1076 (0.7); 2.0718 (0.6); 1.7645 (0.9); 1.7521 (1.3); 1.7412 (1.8); 1.7308 (1.5); 1.7202 (1.5); 1.7093 (1.7); 1.6984 (1.0); 1.6855 (0.7); 0.0080 (1.0); 0.0039 (0.5); -0.0002 (33.7); -0.0085 (0.9) I.1-167:1H NMR (400.1 MHz, CDCl3): δ= 7.5256 (1.1); 7.5194 (1.5); 7.3143 (2.5); 7.3089 (3.2); 7.2934 (6.3); 7.2902 (6.1); 7.2867 (6.1); 7.2669 (203.6); 7.2605 (281.8); 7.1667 (0.4); 7.1020 (0.4); 7.0381 (9.3); 7.0190 (8.2); 7.0029 (1.8); 6.9965 (2.7); 6.9796 (8.3); 6.9684 (11.6); 6.9638 (13.0); 6.9452 (11.2); 6.9238 (0.7); 5.5276 (1.0); 5.4726 (0.3); 5.4107 (4.8); 4.8360 (0.7); 4.7972 (0.7); 4.6733 (8.2); 4.6348 (9.8); 4.4463 (0.4); 4.3584 (1.6); 4.3209 (1.4); 4.2687 (9.5); 4.2308 (7.9); 4.1390 (0.8); 4.1009 (1.4); 4.0830 (0.7); 4.0731 (0.6); 4.0535 (1.6); 4.0396 (3.8); 4.0336 (4.0); 4.0266 (4.6); 4.0212 (5.6); 4.0142 (3.7); 4.0086 (4.2); 4.0018 (2.7); 3.9895 (1.4); 3.9167 (0.3); 3.9098 (0.4); 3.8912 (0.5); 3.8801 (0.4); 3.8699 (0.4); 3.8075 (0.6); 3.6642 (0.4); 3.6540 (4.5); 3.6479 (6.4); 3.4915 (0.3); 2.7359 (0.7); 2.7231 (0.8); 2.6940 (1.1); 2.6812 (1.9); 2.6695 (3.0); 2.6626 (4.3); 2.6533 (5.5); 2.6454 (5.3); 2.6362 (4.1); 2.6183 (0.8); 2.6022 (0.6); 2.5912 (0.8); 2.5660 (0.6); 2.5518 (1.6); 2.5331 (2.9); 2.5092 (5.2); 2.4905 (7.0); 2.4676 (4.8); 2.4604 (3.7); 2.4543 (5.9); 2.4456 (9.3); 2.4370 (7.9); 2.4322 (9.8); 2.4216 (4.8); 2.4157 (9.1); 2.4090 (8.1); 2.4016 (6.2); 2.3960 (7.9); 2.3879 (4.0); 2.3787 (2.3); 2.3733 (3.1); 2.3668 (1.5); 2.3612 (1.3); 2.3486 (1.8); 2.3336 (1.4); 2.3222 (2.4); 2.3172 (2.7); 2.2982 (4.4); 2.2933 (2.3); 2.2846 (3.6); 2.2795 (3.5); 2.2735 (3.5); 2.2659 (4.9); 2.2609 (3.0); 2.2466 (3.9); 2.2419 (3.0); 2.2223 (1.4); 2.1081 (4.6); 2.1027 (6.3); 2.0884 (4.7); 2.0828 (6.3); 2.0715 (4.1); 2.0660 (5.3); 2.0516 (3.8); 2.0462 (5.0); 2.0043 (0.3); 1.9404 (0.6); 1.8544 (0.4); 1.8152 (2.2); 1.8045 (3.2); 1.7956 (3.0); 1.7912 (3.8); 1.7830 (4.4); 1.7773 (3.7); 1.7716 (4.1); 1.7595 (2.8); 1.7482 (2.6); 1.7393 (1.4); 1.7337 (1.6); 1.5655 (56.0); 1.5603 (72.9); 1.2583 (0.7); 0.9113 (0.6); 0.8952 (0.6); 0.8835 (0.7); 0.7904 (2.6); 0.7843 (4.3); 0.7725 (12.4); 0.7681 (12.4); 0.7559 (14.5); 0.7453 (5.5); 0.7376 (4.7); 0.7202 (1.3); 0.7139 (1.1); 0.7071 (1.0); 0.6818 (0.5); 0.6642 (0.8); 0.6565 (0.7); 0.5201 (0.8); 0.4989 (1.4); 0.4940 (1.2); 0.4878 (1.2); 0.4680 (0.6); 0.4569 (3.0); 0.4389 (16.0); 0.4355 (16.0); 0.4292 (15.1); 0.4131 (3.8); 0.4028 (1.1); 0.1458 (0.4); 0.0144 (1.8); 0.0063 (68.5); 0.0000 (97.2) I.1-168:1H NMR (400.0MHz, d6-DMSO): δ= 3.3340 (1.0); 3.1172 (1.3); 3.0788 (1.8); 3.0606 (5.7); 3.0423 (5.9); 3.0242 (1.8); 2.9097 (1.5); 2.6735 (1.5); 2.5250 (0.6); 2.5204 (0.8); 2.5117 (7.4); 2.5071 (15.4); 2.5026 (20.8); 2.4980 (14.4); 2.4934 (6.2); 1.2051 (7.6); 1.1869 (16.0); 1.1687 (7.3); 0.9789 (0.8); -0.0002 (5.5) I.1-169:1H NMR (400.0MHz, d6-DMSO): δ= 12.5442 (1.2); 8.2871 (1.5); 8.2668 (1.6); 7.2211 (2.1); 7.2072 (7.0); 7.1951 (1.8); 7.1769 (1.3); 7.1695 (1.3); 7.1583 (2.0); 7.1510 (1.9); 7.1369 (1.4); 7.1168 (2.4); 7.0962 (1.2); 4.7616 (2.3); 4.7224 (2.5); 4.3034 (1.0); 4.2520 (0.8); 4.2361 (1.0); 4.0907 (2.1); 4.0511 (1.9); 3.6863 (1.1); 3.3130 (142.7); 2.6743 (2.4); 2.6697 (2.9); 2.6653 (2.1); 2.6251 (1.6); 2.6087 (3.7); 2.5897 (3.9); 2.5722 (1.8); 2.5400 (3.0); 2.5232 (8.3); 2.5185 (12.1); 2.5098 (184.3); 2.5053 (404.0); 2.5007 (565.0); 2.4960 (393.6); 2.4915 (174.3); 2.4089 (1.1); 2.3875 (1.0); 2.3683 (1.4); 2.3321 (2.5); 2.3275 (3.3); 2.3226 (2.2); 2.2909 (1.8); 2.2690 (1.8); 2.2571 (2.0); 2.2345 (1.4); 2.0851 (1.0); 2.0731 (1.2); 2.0421 (0.9); 2.0123 (0.9); 1.7541 (1.0); 1.6073 (0.9); 1.5010 (2.1); 1.4874 (2.4); 1.4656 (1.4); 1.1746 (1.4); 1.1557 (3.0); 1.1419 (7.1); 1.1231 (16.0); 1.1042 (6.9); 0.8911 (9.6); 0.8747 (9.5); 0.8230 (9.9); 0.8068 (9.5); 0.0080 (6.4); -0.0002 (256.0); -0.0086 (7.9); -0.1496 (0.9) I.1-170:1H NMR (400.0 MHz, i.e6-DMSO): δ= 6.9334 (0.9); 6.9132 (3.3); 6.8971 (3.6); 6.8918 (0.7); 6.8766 (1.0); 4.4483 (0.9); 4.4101 (1.0); 3.8478 (1.1); 3.8096 (0.9); 3.6126 (1.7); 3.6080 (1.8); 3.5942 (1.8); 3.5899 (1.8); 3.5044 (0.5); 3.4941 (0.6); 3.4839 (0.5); 3.2408 (8.9); 2.5391 (0.7); 2.5288 (0.7); 2.4996 (0.9); 2.4893 (0.9); 2.2962 (5.6); 2.2917 (11.8); 2.2871 (16.0); 2.2825 (11.2); 2.2780 (5.1); 2.2355 (1.0); 2.2138 (1.1); 2.1960 (0.8); 2.1915 (0.6); 2.1742 (1.1); 2.0607 (7.5); 2.0522 (0.9); 2.0383 (0.6); 0.8135 (0.6); 0.2847 (1.4); 0.2801 (1.5); 0.2754 (0.6); 0.2697 (0.6); 0.2644 (1.5); 0.2600 (1.4); 0.2497 (0.5); 0.0261 (0.6); 0.0155 (1.6); 0.0116 (1.5); 0.0038 (1.4); -0.0002 (1.7); -0.2157 (1.5) I.1-171:1H NMR (400.0MHz, d6-DMSO): δ= 11.8025 (3.0); 7.4101 (0.8); 7.4037 (7.4); 7.3987 (2.3); 7.3875 (2.7); 7.3824 (10.0); 7.3761 (1.1); 7.2665 (1.0); 7.2603 (7.5); 7.2552 (2.2); 7.2438 (1.9); 7.2389 (5.5); 7.2325 (0.6); 4.6235 (2.5); 4.5845 (2.9); 4.1260 (2.8); 4.0871 (2.4); 3.8018 (0.9); 3.7912 (1.2); 3.7810 (1.4); 3.7710 (1.2); 3.7605 (0.9); 3.4435 (9.0); 3.3856 (0.7); 3.2134 (36.0); 3.1682 (16.0); 2.7214 (1.8); 2.7104 (1.8); 2.6830 (2.2); 2.6721 (2.3); 2.6651 (0.5); 2.5398 (0.5); 2.5341 (0.6); 2.5297 (0.8); 2.5232 (1.6); 2.5184 (2.1); 2.5098 (32.4); 2.5052 (69.0); 2.5006 (94.5); 2.4959 (65.7); 2.4913 (29.5); 2.4142 (0.6); 2.4095 (0.6); 2.3909 (1.5); 2.3773 (2.4); 2.3725 (1.5); 2.3683 (1.2); 2.3556 (2.3); 2.3492 (1.2); 2.3391 (1.9); 2.3321 (0.6); 2.3273 (0.7); 2.3225 (0.6); 2.3174 (1.9); 2.3021 (1.0); 2.2889 (1.2); 2.2779 (1.6); 2.2647 (1.5); 2.2604 (0.7); 2.2474 (0.5); 2.2360 (0.9); 2.2233 (0.9); 2.1854 (0.6); 2.1663 (1.0); 2.1615 (0.5); 2.1539 (0.8); 2.1472 (0.6); 2.1421 (0.8); 2.1347 (1.2); 2.1298 (0.7); 2.1152 (0.7); 2.1104 (0.8); 1.7521 (0.5); 1.7399 (0.8); 1.7289 (1.0); 1.7184 (0.9); 1.7080 (0.9); 1.6970 (1.0); 1.6861 (0.6); -0.0002 (9.2) I.1-174:1H NMR (400.1 MHz, d6-DMSO): δ= 11.8034 (1.4); 7.4084 (0.5); 7.3928 (0.6); 7.3885 (1.0); 7.3733 (1.0); 7.3691 (0.8); 7.3535 (0.7); 7.1181 (0.4); 7.1114 (0.5); 7.0958 (0.8); 7.0901 (0.9); 7.0767 (1.6); 7.0562 (1.7); 7.0300 (0.7); 7.0254 (0.8); 4.6518 (1.3); 4.6125 (1.5); 4.1514 (1.5); 4.1122 (1.3); 3.8286 (0.4); 3.8182 (0.6); 3.8077 (0.8); 3.7975 (0.6); 3.7875 (0.5); 3.3880 (0.4); 3.3380 (84.3); 3.2887 (0.5); 3.2119 (16.0); 2.7363 (0.9); 2.7254 (0.9); 2.6980 (1.1); 2.6871 (1.1); 2.5240 (0.5); 2.5192 (0.6); 2.5106 (12.5); 2.5060 (27.9); 2.5015 (39.4); 2.4969 (28.4); 2.4923 (13.3); 2.4215 (0.4); 2.4175 (0.4); 2.3961 (1.4); 2.3743 (1.5); 2.3575 (1.5); 2.3358 (1.0); 2.3284 (0.3); 2.3216 (0.6); 2.3082 (0.6); 2.2973 (0.8); 2.2842 (0.8); 2.2555 (0.4); 2.2427 (0.4); 2.2093 (0.3); 2.1904 (0.5); 2.1781 (0.4); 2.1712 (0.3); 2.1663 (0.4); 2.1589 (0.6); 2.1539 (0.4); 2.1395 (0.4); 2.1347 (0.4); 1.7537 (0.4); 1.7424 (0.5); 1.7323 (0.5); 1.7218 (0.5); 1.7107 (0.5) I.1-175:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.7756 (2.3); 7.4771 (3.8); 7.4546 (3.9); 7.1315 (1.7); 7.1110 (6.6); 7.0979 (7.0); 7.0772 (1.6); 6.8600 (4.4); 6.8375 (4.1); 4.6493 (1.7); 4.6110 (1.9); 4.3084 (1.0); 4.2978 (2.6); 4.2867 (2.8); 4.2767 (1.2); 4.0989 (2.3); 4.0877 (3.7); 4.0763 (1.8); 4.0517 (2.0); 4.0137 (1.8); 3.7263 (0.6); 3.7162 (0.9); 3.7055 (1.1); 3.6957 (1.0); 3.6852 (0.7); 3.3670 (112.0); 3.1677 (0.8); 2.7819 (1.1); 2.7718 (1.2); 2.7422 (1.5); 2.7321 (1.4); 2.5100 (32.8); 2.5058 (67.4); 2.5014 (91.0); 2.4969 (64.3); 2.4764 (1.7); 2.4544 (1.5); 2.4364 (1.4); 2.4147 (1.7); 2.3910 (1.1); 2.3726 (0.8); 2.3674 (0.8); 2.3494 (0.7); 2.3284 (0.6); 2.2644 (13.8); 2.2481 (1.1); 2.2345 (1.1); 2.2062 (0.6); 2.1933 (0.7); 2.1556 (0.5); 2.1369 (0.6); 2.1241 (0.5); 2.1058 (0.8); 2.0812 (0.5); 1.9988 (16.0); 1.7158 (0.5); 1.7042 (0.7); 1.6934 (0.6); 1.6839 (0.7); 1.6723 (0.6); - 0.0002 (2.1) I.1-177:1H NMR (400.0MHz, d6-DMSO): δ= 8.6552 (3.3); 8.6402 (6.1); 8.6239 (3.2); 7.3799 (2.4); 7.3761 (2.5); 7.3557 (5.5); 7.3340 (5.4); 7.3132 (2.9); 7.3094 (2.8); 7.2088 (3.2); 7.2047 (3.4); 7.1959 (3.3); 7.1887 (5.8); 7.1849 (6.2); 7.1761 (5.7); 7.1724 (6.2); 7.1685 (4.0); 7.1644 (3.7); 7.1556 (3.2); 7.1518 (3.4); 7.0798 (5.6); 7.0637 (7.7); 7.0444 (4.1); 4.7384 (8.9); 4.6989 (10.4); 4.2375 (11.5); 4.1977 (9.9); 3.9285 (2.6); 3.9067 (7.8); 3.9038 (7.8); 3.8879 (8.0); 3.8821 (8.2); 3.8790 (7.8); 3.8660 (7.6); 3.8631 (7.8); 3.8575 (3.4); 3.8383 (3.1); 3.8231 (4.0); 3.8123 (5.5); 3.8022 (6.9); 3.7921 (5.5); 3.7816 (3.9); 3.7713 (1.9); 3.3577 (1.2); 3.3081 (337.7); 3.2588 (2.5); 3.1685 (0.8); 2.6741 (2.9); 2.6693 (4.1); 2.6647 (2.8); 2.6377 (8.4); 2.6265 (8.6); 2.6022 (10.6); 2.5910 (10.0); 2.5502 (1.9); 2.5395 (2.6); 2.5228 (9.6); 2.5181 (13.9); 2.5095 (229.2); 2.5049 (503.0); 2.5002 (704.9); 2.4956 (486.0); 2.4910 (215.3); 2.4552 (3.4); 2.4504 (4.5); 2.4458 (3.2); 2.4106 (2.3); 2.3909 (3.2); 2.3686 (6.6); 2.3490 (6.2); 2.3315 (4.3); 2.3248 (15.4); 2.3027 (10.6); 2.2892 (11.2); 2.2776 (6.7); 2.2669 (16.0); 2.2535 (7.9); 2.2359 (2.9); 2.2248 (4.3); 2.2119 (4.1); 2.1591 (2.8); 2.1397 (4.8); 2.1352 (2.9); 2.1273 (3.5); 2.1203 (3.0); 2.1157 (4.2); 2.1080 (5.7); 2.1036 (3.3); 2.0966 (2.1); 2.0884 (3.2); 2.0839 (4.3); 2.0644 (2.0); 1.7623 (2.3); 1.7499 (3.5); 1.7388 (4.7); 1.7282 (4.0); 1.7174 (4.0); 1.7071 (4.0); 1.6961 (2.6); 1.6834 (1.7); 0.0081 (1.7); -0.0002 (63.7); -0.0085 (1.7) I.1-178:1H NMR (400.0MHz, d6-DMSO): δ= 8.0421 (3.8); 7.3784 (1.6); 7.3745 (1.7); 7.3583 (3.3); 7.3541 (3.6); 7.3481 (1.9); 7.3382 (2.2); 7.3319 (3.5); 7.3119 (1.9); 7.3081 (1.9); 7.2073 (2.1); 7.2033 (2.2); 7.1945 (2.1); 7.1875 (3.8); 7.1837 (4.0); 7.1747 (3.7); 7.1710 (4.1); 7.1672 (2.5); 7.1630 (2.4); 7.1543 (2.1); 7.1505 (2.3); 7.1265 (0.6); 7.1158 (0.8); 7.0740 (3.9); 7.0580 (5.2); 7.0385 (2.8); 4.7382 (6.0); 4.6989 (6.8); 4.2292 (7.5); 4.1894 (6.5); 3.8099 (1.2); 3.7986 (2.3); 3.7885 (3.6); 3.7783 (4.6); 3.7680 (3.6); 3.7582 (2.4); 3.7472 (1.3); 3.3987 (1.0); 3.3669 (1.3); 3.3169 (338.3); 3.3009 (29.3); 3.2875 (18.9); 3.2756 (1.7); 3.2691 (2.6); 3.2657 (2.4); 3.2524 (0.6); 3.2252 (183.9); 3.1996 (6.6); 3.1858 (16.0); 3.1718 (13.6); 3.1572 (4.0); 3.0471 (1.0); 2.6743 (1.6); 2.6696 (2.5); 2.6651 (1.6); 2.5505 (0.9); 2.5400 (1.5); 2.5231 (10.3); 2.5185 (8.7); 2.5098 (139.7); 2.5052 (300.9); 2.5006 (423.9); 2.4960 (294.5); 2.4914 (131.5); 2.4765 (8.2); 2.4558 (2.3); 2.4513 (2.8); 2.4467 (2.0); 2.4045 (1.7); 2.3815 (2.1); 2.3618 (4.4); 2.3420 (4.1); 2.3320 (2.2); 2.3274 (2.9); 2.3191 (3.9); 2.2787 (4.3); 2.2658 (4.3); 2.2547 (5.3); 2.2417 (5.2); 2.2371 (2.4); 2.2242 (8.8); 2.2128 (3.2); 2.2029 (7.6); 2.1894 (5.9); 2.1682 (5.6); 2.1407 (2.0); 2.1212 (3.3); 2.1168 (2.0); 2.1091 (2.3); 2.1019 (2.0); 2.0973 (2.9); 2.0896 (4.0); 2.0851 (2.4); 2.0775 (1.4); 2.0700 (2.2); 2.0654 (3.0); 2.0458 (1.3); 1.7752 (1.6); 1.7628 (2.4); 1.7520 (3.3); 1.7417 (2.8); 1.7308 (2.7); 1.7204 (3.0); 1.7095 (1.8); 1.6966 (1.3); 0.0080 (0.8); -0.0002 (33.1); -0.0086 (0.9) I.1-179:1H NMR (400.1 MHz, i.e6-DMSO): δ= 6.8483 (0.6); 6.8401 (0.6); 6.8321 (2.3); 6.8242 (0.7); 6.8158 (0.7); 6.8096 (0.7); 6.7932 (2.1); 6.7868 (0.7); 6.7766 (0.7); 5.7925 (3.6); 5.7539 (3.4); 5.6221 (0.3); 5.5896 (0.8); 5.5842 (1.0); 5.5797 (1.4); 5.5763 (1.0); 5.5704 (0.9); 3.4324 (0.8); 3.3076 (12.1); 3.1691 (1.1); 2.9993 (3.5); 2.9952 (2.6); 2.9898 (3.0); 2.9861 (3.3); 2.6740 (0.7); 2.6695 (0.9); 2.6653 (0.8); 2.6481 (0.4); 2.6405 (0.4); 2.6223 (0.4); 2.6060 (0.8); 2.6017 (0.7); 2.5578 (0.3); 2.5532 (0.3); 2.5332 (0.3); 2.5228 (1.8); 2.5094 (52.8); 2.5050 (109.3); 2.5006 (147.2); 2.4962 (105.1); 2.4919 (49.5); 2.4583 (0.4); 2.4536 (0.4); 2.4489 (0.3); 2.3902 (11.6); 2.3836 (16.0); 2.3321 (0.7); 2.3275 (0.9); 2.3227 (0.7); 2.3187 (0.4); 0.0081 (0.8); 0.0010 (20.4); 0.0000 (20.9) I.1-180:1H NMR (400.0MHz, d6-DMSO): δ= 8.4095 (4.9); 7.3744 (2.0); 7.3575 (4.0); 7.3538 (4.5); 7.3317 (4.4); 7.3112 (2.4); 7.2076 (2.6); 7.2037 (2.6); 7.1949 (2.6); 7.1877 (4.6); 7.1840 (5.0); 7.1750 (4.5); 7.1715 (4.9); 7.1673 (3.0); 7.1634 (2.9); 7.1546 (2.7); 7.1510 (2.8); 7.0804 (4.6); 7.0644 (6.4); 7.0449 (3.4); 4.7434 (7.4); 4.7041 (8.4); 4.2213 (9.2); 4.1818 (8.0); 3.8383 (15.1); 3.8320 (15.9); 3.8243 (16.0); 3.8181 (14.8); 3.8006 (3.0); 3.7903 (4.6); 3.7802 (5.6); 3.7698 (4.5); 3.7597 (3.0); 3.7490 (1.6); 3.4184 (0.8); 3.3165 (259.7); 3.2688 (2.2); 3.2161 (0.6); 3.1685 (3.5); 3.0919 (11.4); 2.6741 (1.9); 2.6695 (2.8); 2.6646 (2.0); 2.5476 (7.1); 2.5361 (7.4); 2.5229 (6.9); 2.5182 (10.8); 2.5096 (165.2); 2.5050 (354.4); 2.5003 (499.5); 2.4957 (342.2); 2.4911 (152.5); 2.4552 (2.5); 2.4508 (3.1); 2.4091 (2.2); 2.3865 (2.6); 2.3663 (5.4); 2.3464 (5.1); 2.3364 (1.6); 2.3319 (2.5); 2.3229 (5.6); 2.2790 (4.1); 2.2663 (5.0); 2.2549 (6.4); 2.2422 (6.4); 2.2353 (9.2); 2.2246 (2.7); 2.2135 (11.0); 2.2003 (10.0); 2.1786 (6.6); 2.1487 (2.4); 2.1292 (4.1); 2.1171 (2.9); 2.1098 (2.4); 2.1053 (3.4); 2.0977 (4.7); 2.0932 (2.7); 2.0856 (1.7); 2.0778 (2.7); 2.0735 (3.8); 2.0536 (1.5); 1.7651 (1.9); 1.7534 (2.9); 1.7422 (3.6); 1.7318 (3.5); 1.7206 (3.3); 1.7104 (3.3); 1.6990 (2.2); 1.6872 (1.5); 0.0080 (1.3); -0.0002 (45.0); -0.0085 (1.4) I.1-181:1H NMR (400.0MHz, d6-DMSO): δ= 8.3390 (0.7); 8.3253 (1.3); 8.3110 (0.7); 7.3583 (1.0); 7.3357 (1.0); 7.3156 (0.6); 7.2061 (1.8); 7.2014 (2.0); 7.1897 (5.0); 7.1870 (7.1); 7.1838 (4.8); 7.1730 (4.4); 7.1703 (4.5); 7.1599 (2.7); 7.1546 (2.2); 7.1451 (1.2); 7.1393 (1.2); 7.1345 (0.7); 7.1204 (0.6); 7.0765 (1.1); 7.0602 (1.5); 7.0410 (0.7); 4.7418 (1.4); 4.7013 (1.7); 4.2623 (2.5); 4.2542 (2.6); 4.2485 (2.7); 4.2401 (3.8); 4.2002 (1.6); 3.8266 (0.6); 3.8162 (0.8); 3.8060 (1.0); 3.7960 (0.9); 3.7857 (0.6); 3.3424 (236.4); 3.2908 (1.6); 3.1672 (2.3); 3.1529 (2.5); 2.6746 (1.3); 2.6700 (1.8); 2.6654 (1.3); 2.6229 (1.4); 2.6038 (5.3); 2.5907 (1.6); 2.5851 (5.0); 2.5665 (2.8); 2.5549 (0.9); 2.5495 (0.7); 2.5448 (1.0); 2.5402 (2.2); 2.5233 (5.0); 2.5187 (7.7); 2.5100 (103.3); 2.5055 (221.3); 2.5008 (305.4); 2.4962 (213.2); 2.4916 (94.7); 2.4596 (0.6); 2.4548 (1.0); 2.4501 (1.6); 2.4456 (1.4); 2.4018 (0.6); 2.3829 (0.7); 2.3599 (1.2); 2.3369 (1.7); 2.3324 (1.8); 2.3277 (2.1); 2.3229 (1.6); 2.3183 (1.5); 2.2834 (1.9); 2.2749 (1.6); 2.2617 (2.0); 2.2488 (2.0); 2.2265 (1.5); 2.2090 (0.7); 2.1616 (0.5); 2.1422 (0.8); 2.1300 (0.6); 2.1180 (0.7); 2.1106 (1.0); 2.0866 (0.8); 2.0730 (1.0); 1.7871 (0.6); 1.7766 (0.8); 1.7663 (0.7); 1.7550 (0.7); 1.7449 (0.8); 1.2098 (1.5); 1.1936 (1.5); 1.1566 (7.0); 1.1378 (16.0); 1.1189 (6.8); 0.0080 (1.2); -0.0002 (41.8); -0.0085 (1.2) I.1-182:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0946 (0.7); 7.4655 (3.6); 7.3567 (0.5); 7.3529 (0.6); 7.3307 (0.6); 7.1828 (0.6); 7.1790 (0.7); 7.1698 (0.6); 7.1665 (0.7); 7.0682 (0.6); 7.0520 (0.8); 4.7284 (0.9); 4.6890 (1.1); 4.2126 (1.2); 4.1730 (1.0); 4.0086 (1.9); 4.0026 (1.9); 3.9997 (2.2); 3.9958 (1.9); 3.9903 (2.0); 3.9815 (3.9); 3.9633 (4.0); 3.9452 (1.3); 3.7911 (0.6); 3.7811 (0.7); 3.7711 (0.6); 3.4698 (8.3); 2.5229 (1.4); 2.5185 (1.2); 2.5098 (16.8); 2.5052 (35.8); 2.5006 (50.3); 2.4960 (34.8); 2.4913 (15.5); 2.4763 (1.0); 2.3411 (0.7); 2.3224 (0.8); 2.2987 (0.5); 2.2722 (0.5); 2.2592 (0.6); 2.2482 (0.8); 2.2352 (0.8); 2.2118 (1.1); 2.2064 (0.5); 2.1902 (1.1); 2.1771 (0.9); 2.1694 (1.1); 2.1554 (0.8); 2.1195 (0.5); 2.0880 (0.6); 2.0638 (16.0); 1.7505 (0.5); 1.3113 (5.1); 1.2932 (11.7); 1.2750 (5.0); 1.2495 (0.7); -0.0002 (3.5) I.1-183:1H NMR (400.0MHz, d6-DMSO): δ= 8.5312 (1.1); 8.5178 (0.6); 8.2879 (3.0); 8.2828 (3.0); 7.7049 (2.0); 7.6986 (1.9); 7.6844 (2.4); 7.6781 (2.3); 7.4784 (3.8); 7.4579 (3.2); 7.1343 (2.5); 7.1143 (6.6); 7.0907 (7.4); 7.0704 (2.6); 4.6568 (2.0); 4.6187 (2.2); 4.2673 (2.3); 4.2588 (2.6); 4.2526 (2.5); 4.2446 (2.3); 3.9968 (2.2); 3.9588 (2.0); 3.7359 (0.7); 3.7251 (0.9); 3.7145 (1.1); 3.7048 (0.9); 3.6940 (0.7); 3.3460 (56.6); 3.1687 (0.6); 2.5892 (1.4); 2.5783 (1.4); 2.5542 (1.8); 2.5431 (1.6); 2.5232 (1.2); 2.5184 (1.8); 2.5098 (29.4); 2.5052 (63.4); 2.5006 (88.2); 2.4960 (61.4); 2.4914 (27.5); 2.3611 (0.5); 2.3374 (1.3); 2.3274 (0.6); 2.3185 (1.2); 2.2959 (1.0); 2.2728 (16.0); 2.2545 (1.2); 2.2444 (1.4); 2.2305 (1.4); 2.2126 (0.6); 2.2031 (2.1); 2.1886 (0.7); 2.1810 (1.6); 2.1685 (1.4); 2.1460 (1.3); 2.0716 (0.7); 2.0529 (0.7); 2.0405 (0.6); 2.0288 (0.7); 2.0214 (0.9); 1.9971 (0.7); 1.7027 (0.6); 1.6915 (0.8); 1.6813 (0.7); 1.6697 (0.6); 1.6594 (0.7); -0.0002 (0.6) I.1-184:1H NMR (400.6 MHz, i.e6-DMSO): δ= 7.5903 (6.8); 7.5867 (7.3); 7.5704 (8.7); 7.5667 (8.3); 7.3737 (8.6); 7.3541 (16.0); 7.3343 (9.2); 7.1940 (7.4); 7.1904 (7.7); 7.1746 (6.4); 7.1710 (6.2); 7.1587 (3.7); 7.0268 (7.6); 6.8950 (3.8); 4.6609 (6.9); 4.6192 (8.3); 4.2949 (8.1); 4.2532 (6.6); 3.8920 (1.6); 3.8824 (2.6); 3.8725 (3.4); 3.8630 (3.8); 3.8506 (3.4); 3.8410 (3.0); 3.4559 (5.6); 3.1673 (3.0); 2.7995 (4.0); 2.7899 (4.0); 2.7603 (5.0); 2.7507 (4.8); 2.6749 (1.5); 2.6703 (2.0); 2.6656 (1.6); 2.5238 (8.8); 2.5106 (101.5); 2.5060 (207.0); 2.5015 (282.6); 2.4969 (195.7); 2.4923 (88.3); 2.4775 (6.0); 2.4615 (3.1); 2.4547 (4.7); 2.4389 (4.6); 2.4209 (3.6); 2.4159 (3.5); 2.4014 (1.5); 2.3879 (1.4); 2.3391 (2.8); 2.3330 (2.1); 2.3282 (4.0); 2.3152 (4.7); 2.3037 (4.8); 2.2748 (5.9); 2.2692 (4.3); 2.2621 (3.0); 2.2560 (2.2); 2.2440 (3.5); 2.2314 (1.2); 2.2247 (2.0); 2.2196 (1.9); 2.2002 (1.0); 2.0857 (2.0); 2.0736 (3.2); 1.8267 (0.9); 1.8019 (2.3); 1.7934 (2.4); 1.7837 (2.8); 1.7765 (1.9); 1.7712 (2.0); 1.7632 (1.8); 1.7521 (2.0); 1.7408 (1.2); 1.3240 (0.5); 0.0080 (1.2); -0.0002 (31.2); -0.0085 (0.8) I.1-185:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1473 (2.1); 7.1271 (6.6); 7.1088 (7.4); 7.0883 (2.3); 4.8808 (0.7); 4.8652 (2.0); 4.8495 (2.7); 4.8339 (2.0); 4.8182 (0.8); 4.6551 (1.9); 4.6168 (2.2); 4.0517 (2.2); 4.0134 (2.0); 3.7185 (0.7); 3.7081 (1.1); 3.6976 (1.2); 3.6875 (1.1); 3.6770 (0.8); 3.4114 (1.0); 3.3756 (116.5); 2.7000 (1.6); 2.6899 (1.7); 2.6713 (0.5); 2.6609 (2.2); 2.6507 (2.0); 2.5248 (0.8); 2.5200 (1.4); 2.5114 (28.3); 2.5069 (61.2); 2.5023 (83.4); 2.4977 (58.8); 2.4931 (26.8); 2.3906 (3.2); 2.3689 (2.6); 2.3514 (2.1); 2.3296 (2.1); 2.3246 (0.5); 2.2909 (0.9); 2.2756 (16.0); 2.2665 (1.8); 2.2523 (1.4); 2.2245 (0.7); 2.2109 (0.8); 2.1694 (0.5); 2.1501 (0.7); 2.1378 (0.6); 2.1320 (0.5); 2.1254 (0.6); 2.1197 (0.8); 2.1134 (0.6); 2.1001 (0.6); 2.0938 (0.6); 2.0753 (0.5); 1.7055 (0.6); 1.6943 (0.9); 1.6869 (0.5); 1.6834 (0.6); 1.6739 (0.7); 1.6697 (0.5); 1.6623 (0.8); 1.1504 (12.6); 1.1453 (12.8); 1.1347 (12.6); 1.1297 (12.7); -0.0002 (9.1) I.1-186:1H NMR (400.0 MHz, d6-DMSO): δ= 7.1468 (2.2); 7.1268 (6.2); 7.1053 (5.9); 7.0849 (2.0); 5.7713 (0.8); 5.7455 (1.2); 5.7284 (1.2); 5.7026 (0.9); 5.1026 (0.5); 5.0986 (1.3); 5.0938 (1.6); 5.0899 (0.6); 5.0555 (1.2); 5.0508 (2.0); 5.0482 (1.7); 5.0434 (1.2); 5.0257 (0.6); 5.0226 (1.3); 5.0178 (1.1); 4.6542 (1.6); 4.6159 (1.8); 4.0472 (2.3); 4.0431 (2.8); 4.0262 (5.1); 4.0096 (4.4); 3.7129 (0.6); 3.7023 (0.9); 3.6916 (1.0); 3.6815 (0.9); 3.6713 (0.6); 3.3891 (1.6); 3.3796 (1.2); 3.3722 (2.2); 3.3389 (363.2); 3.3104 (1.4); 3.3017 (1.1); 3.1667 (0.8); 2.7378 (1.2); 2.7278 (1.2); 2.6983 (1.5); 2.6882 (1.4); 2.6760 (1.2); 2.6712 (1.4); 2.6667 (1.2); 2.5568 (0.8); 2.5521 (0.8); 2.5471 (0.7); 2.5415 (1.2); 2.5363 (1.0); 2.5318 (1.2); 2.5245 (3.7); 2.5199 (5.4); 2.5112 (74.0); 2.5067 (155.1); 2.5021 (211.4); 2.4975 (150.0); 2.4930 (67.8); 2.4282 (1.8); 2.4166 (0.9); 2.4063 (1.7); 2.3889 (1.9); 2.3743 (1.0); 2.3669 (1.9); 2.3501 (0.8); 2.3380 (0.5); 2.3335 (1.0); 2.3289 (1.4); 2.3244 (1.0); 2.3197 (0.5); 2.3043 (1.0); 2.2911 (1.8); 2.2876 (3.2); 2.2845 (2.7); 2.2757 (16.0); 2.2612 (1.6); 2.2546 (1.1); 2.2473 (1.4); 2.2304 (0.7); 2.2192 (0.9); 2.2058 (1.0); 2.1411 (0.6); 2.1283 (0.6); 2.1223 (0.6); 2.1160 (0.7); 2.1099 (0.8); 2.1039 (0.5); 2.0904 (0.6); 2.0755 (0.5); 1.7149 (0.5); 1.7022 (0.7); 1.6907 (0.9); 1.6796 (0.7); 1.6702 (0.7); 1.6588 (0.8); 0.0080 (0.8); -0.0002 (28.0); -0.0085 (0.8) I.1-188:1H NMR (400.0MHz, d6-DMSO): δ= 7.8853 (0.8); 7.3594 (0.6); 7.3554 (0.7); 7.3334 (0.7); 7.3295 (0.6); 7.1881 (0.7); 7.1844 (0.8); 7.1754 (0.7); 7.1718 (0.8); 7.0705 (0.7); 7.0543 (1.0); 7.0511 (0.9); 7.0350 (0.5); 4.7320 (1.1); 4.6922 (1.3); 4.2348 (1.4); 4.1951 (1.2); 3.7968 (0.6); 3.7865 (0.9); 3.7764 (0.6); 3.0530 (0.5); 3.0460 (0.5); 3.0348 (1.3); 3.0277 (1.1); 3.0208 (1.2); 3.0140 (1.3); 3.0022 (0.6); 2.9960 (0.6); 2.5117 (5.5); 2.5072 (12.1); 2.5025 (17.0); 2.4979 (12.6); 2.4933 (5.4); 2.4853 (1.1); 2.4623 (1.2); 2.4504 (1.2); 2.3572 (0.8); 2.3381 (0.8); 2.3344 (0.8); 2.3152 (0.6); 2.2891 (0.6); 2.2755 (0.8); 2.2651 (1.0); 2.2516 (0.9); 2.1893 (1.2); 2.1682 (1.2); 2.1545 (1.1); 2.1334 (1.1); 2.1259 (0.6); 2.1019 (0.5); 2.0944 (0.7); 2.0703 (0.5); 1.7397 (0.6); 1.7293 (0.5); 1.7078 (0.6); 1.5512 (0.8); 1.5344 (1.1); 1.5176 (1.0); 1.5009 (0.5); 1.2729 (1.4); 1.2550 (3.4); 1.2372 (3.3); 1.2193 (1.1); 0.8541 (16.0); 0.8375 (15.3); -0.0002 (1.9) I.1-189:1H NMR (400.0 MHz, CDCl3): δ= 7.5560 (5.9); 7.5530 (6.1); 7.5360 (6.4); 7.5330 (6.6); 7.5212 (0.8); 7.2782 (2.7); 7.2751 (2.8); 7.2623 (132.8); 7.2565 (6.9); 7.2413 (5.8); 7.2381 (5.7); 7.2110 (6.1); 7.2064 (7.5); 7.1920 (3.7); 7.1873 (3.4); 7.1267 (4.2); 7.1219 (4.0); 7.1087 (5.2); 7.1068 (5.2); 7.1038 (4.8); 7.1021 (4.9); 7.0948 (3.4); 7.0887 (3.5); 7.0838 (4.3); 7.0789 (2.3); 7.0762 (2.5); 7.0693 (4.4); 7.0624 (1.3); 7.0578 (1.8); 7.0500 (8.0); 7.0431 (7.7); 7.0397 (5.8); 7.0348 (10.0); 7.0264 (4.3); 7.0241 (3.8); 7.0140 (0.8); 7.0073 (0.7); 6.9982 (0.7); 5.5102 (2.0); 5.2991 (0.7); 4.8492 (3.9); 4.8456 (3.9); 4.8104 (4.5); 4.8068 (4.4); 4.2368 (5.8); 4.1981 (5.1); 3.9487 (0.9); 3.9377 (2.0); 3.9267 (2.4); 3.9177 (2.5); 3.9154 (2.6); 3.9065 (2.4); 3.8955 (2.1); 3.8846 (1.0); 3.5526 (2.5); 3.5480 (2.4); 3.5348 (6.3); 3.5309 (5.6); 3.5199 (5.5); 3.5160 (6.9); 3.5024 (2.7); 3.4989 (2.8); 2.9729 (8.0); 2.9556 (16.0); 2.9382 (7.2); 2.6001 (4.1); 2.5894 (4.1); 2.5640 (4.7); 2.5532 (4.6); 2.5196 (0.9); 2.5010 (1.2); 2.4977 (1.1); 2.4771 (3.0); 2.4580 (2.7); 2.4547 (2.5); 2.4347 (2.5); 2.4174 (3.0); 2.4029 (3.6); 2.3933 (4.2); 2.3789 (4.2); 2.3746 (1.5); 2.3601 (1.3); 2.3503 (2.0); 2.3361 (1.9); 2.2634 (1.6); 2.2443 (2.5); 2.2394 (1.5); 2.2307 (2.0); 2.2252 (1.6); 2.2201 (2.1); 2.2116 (2.8); 2.2065 (1.8); 2.2012 (1.2); 2.1925 (1.7); 2.1873 (2.2); 2.1683 (1.2); 2.1321 (5.4); 2.1094 (5.3); 2.0959 (4.8); 2.0733 (4.7); 1.8186 (1.4); 1.8074 (1.5); 1.8046 (1.7); 1.7940 (2.1); 1.7840 (1.9); 1.7808 (1.6); 1.7746 (1.5); 1.7714 (1.9); 1.7605 (1.7); 1.7510 (1.3); 1.7480 (1.2); 1.7366 (1.1); 0.0080 (1.1); -0.0002 (37.7); -0.0085 (1.1) I.1-190:1H NMR (400.0MHz, d6-DMSO): δ= 7.9148 (1.0); 7.3566 (1.0); 7.3527 (1.0); 7.3467 (0.5); 7.3368 (0.6); 7.3309 (1.0); 7.3267 (0.9); 7.3105 (0.5); 7.2075 (0.6); 7.2034 (0.6); 7.1947 (0.6); 7.1875 (1.1); 7.1837 (1.1); 7.1747 (1.0); 7.1712 (1.1); 7.1673 (0.7); 7.1632 (0.6); 7.1543 (0.6); 7.1508 (0.6); 7.0711 (1.1); 7.0549 (1.5); 7.0358 (0.7); 4.7323 (1.7); 4.6926 (2.0); 4.2338 (2.2); 4.1940 (1.8); 3.8082 (0.7); 3.7979 (1.0); 3.7878 (1.3); 3.7775 (1.0); 3.7674 (0.7); 3.3174 (82.7); 3.0622 (0.8); 3.0441 (2.6); 3.0303 (2.8); 3.0261 (2.9); 3.0123 (2.7); 3.0082 (1.1); 2.9943 (0.9); 2.5233 (1.0); 2.5186 (1.5); 2.5100 (21.1); 2.5054 (45.2); 2.5008 (62.5); 2.4962 (43.6); 2.4916 (19.9); 2.4772 (1.5); 2.4541 (1.7); 2.4421 (1.9); 2.3815 (0.6); 2.3587 (1.2); 2.3368 (1.2); 2.3167 (1.0); 2.2855 (1.0); 2.2719 (1.2); 2.2614 (1.4); 2.2480 (1.4); 2.2439 (0.6); 2.2195 (0.8); 2.2063 (0.8); 2.1793 (2.0); 2.1581 (1.9); 2.1488 (0.7); 2.1444 (1.7); 2.1295 (1.0); 2.1234 (1.8); 2.1173 (0.7); 2.1102 (0.6); 2.1056 (0.8); 2.0980 (1.1); 2.0934 (0.6); 2.0785 (0.6); 2.0739 (0.8); 1.7541 (0.7); 1.7434 (1.0); 1.7333 (0.8); 1.7221 (0.8); 1.7116 (0.8); 1.7010 (0.5); 0.9946 (7.5); 0.9765 (16.0); 0.9584 (7.2); -0.0002 (1.1) I.1-191:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.2662 (0.8); 8.2461 (1.8); 8.2265 (1.0); 7.1440 (1.6); 7.1235 (8.3); 7.1152 (6.2); 7.0936 (1.2); 4.6607 (2.0); 4.6225 (2.2); 4.1993 (0.7); 4.1839 (0.7); 4.0557 (1.0); 4.0208 (1.5); 3.9834 (1.2); 3.6889 (1.0); 3.6794 (0.9); 3.3724 (1.0); 3.3540 (2.0); 3.3215 (663.9); 3.2731 (2.3); 3.1674 (0.9); 2.6746 (1.5); 2.6700 (2.2); 2.6653 (1.6); 2.5608 (1.2); 2.5234 (5.3); 2.5185 (7.8); 2.5100 (134.1); 2.5055 (291.3); 2.5009 (405.4); 2.4963 (285.9); 2.4918 (130.2); 2.4520 (1.4); 2.3736 (0.7); 2.3276 (3.0); 2.3232 (2.2); 2.2760 (16.0); 2.2554 (1.0); 2.2453 (1.1); 2.2310 (1.0); 2.2145 (1.1); 2.1920 (1.0); 2.1757 (0.9); 2.1517 (0.9); 2.1172 (0.8); 1.9985 (0.8); 1.5816 (0.7); 1.5101 (1.3); 1.4974 (1.8); 1.4862 (2.1); 1.4760 (1.3); 1.4628 (1.2); 0.8930 (6.6); 0.8769 (6.3); 0.8283 (5.7); 0.8250 (5.3); 0.8119 (5.8); -0.0002 (14.5) I.1-193:1H NMR (400.0MHz, CDCl3): δ= 7.2624 (10.9); 7.0456 (0.6); 7.0382 (0.8); 7.0354 (0.5); 7.0294 (0.8); 6.3377 (0.8); 6.3324 (0.9); 6.3197 (2.4); 6.3142 (1.3); 5.2992 (0.7); 4.2308 (0.5); 3.7742 (16.0); 2.7484 (0.6); 2.7313 (1.3); 2.7141 (0.6); - 0.0002 (3.1) I.1-194:1H NMR (400.0MHz, d6-DMSO): δ= 7.4139 (3.9); 7.3961 (10.3); 7.3770 (8.5); 7.3537 (3.3); 7.3337 (6.0); 7.3118 (4.7); 7.2911 (2.0); 7.2186 (11.3); 7.2152 (15.4); 7.1973 (11.5); 7.1268 (2.8); 7.1124 (2.7); 6.9103 (2.5); 4.5334 (2.0); 4.4962 (2.4); 4.1167 (2.4); 4.0751 (2.0); 3.8125 (2.4); 3.3769 (0.8); 3.3285 (209.0); 3.2797 (1.4); 3.2234 (0.6); 3.1689 (2.0); 3.1051 (16.0); 2.6747 (1.1); 2.6701 (1.5); 2.6654 (1.0); 2.6609 (0.6); 2.5401 (0.6); 2.5234 (3.4); 2.5187 (5.2); 2.5101 (89.3); 2.5055 (193.0); 2.5009 (268.9); 2.4963 (187.8); 2.4917 (84.6); 2.4517 (1.4); 2.4294 (1.8); 2.3901 (2.2); 2.3323 (1.4); 2.3277 (1.9); 2.3231 (1.4); 2.2402 (4.0); 2.2191 (4.6); 2.2051 (4.1); 2.1778 (3.2); 2.1425 (2.4); 2.1222 (1.9); 2.1008 (1.9); 2.0718 (2.4); 1.6628 (2.0); -0.0002 (1.3) I.1-195:1H NMR (400.0MHz, d6-DMSO): δ= 7.8098 (0.8); 7.7906 (0.8); 7.1441 (1.9); 7.1238 (7.4); 7.1094 (8.2); 7.0888 (2.0); 4.6573 (2.0); 4.6194 (2.2); 4.0180 (2.3); 3.9800 (2.0); 3.8206 (0.8); 3.8040 (1.2); 3.7853 (1.2); 3.7689 (0.8); 3.7185 (0.7); 3.7080 (0.9); 3.6973 (1.1); 3.6877 (1.0); 3.6766 (0.7); 3.3845 (24.5); 3.1681 (1.1); 2.6694 (0.7); 2.5229 (1.6); 2.5181 (2.4); 2.5094 (39.5); 2.5049 (85.3); 2.5003 (119.0); 2.4957 (83.1); 2.4911 (37.4); 2.4575 (1.7); 2.4461 (1.8); 2.4232 (1.9); 2.4119 (1.8); 2.3640 (0.5); 2.3411 (1.2); 2.3316 (0.6); 2.3224 (1.5); 2.2995 (1.0); 2.2757 (16.0); 2.2657 (1.4); 2.2517 (1.2); 2.2414 (1.3); 2.2276 (1.3); 2.2100 (0.6); 2.1995 (0.7); 2.1859 (0.6); 2.0826 (1.7); 2.0717 (0.7); 2.0603 (1.8); 2.0483 (1.6); 2.0310 (0.8); 2.0258 (1.8); 2.0198 (0.8); 2.0122 (0.9); 2.0075 (0.6); 1.9929 (0.6); 1.9879 (0.7); 1.7033 (0.6); 1.6917 (0.8); 1.6813 (0.7); 1.6702 (0.7); 1.6598 (0.7); 1.0273 (12.2); 1.0228 (12.3); 1.0109 (12.2); 1.0064 (12.1); 0.0080 (1.0); -0.0002 (33.6); -0.0085 (1.0) I.1-196:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.0772 (0.5); 4.7265 (0.6); 4.6868 (0.7); 4.2454 (0.7); 4.2058 (0.6); 3.3204 (27.1); 3.2966 (1.1); 2.6575 (14.5); 2.5190 (0.6); 2.5104 (9.0); 2.5058 (19.2); 2.5012 (26.3); 2.4965 (18.2); 2.4919 (8.1); 2.3812 (0.7); 2.3693 (0.8); 2.3500 (0.5); 2.3462 (0.8); 2.3341 (1.0); 2.3279 (0.5); 2.2205 (0.5); 1.9824 (0.8); 1.9602 (0.8); 1.9475 (0.7); 1.9252 (0.7); 1.7644 (0.5); 1.7551 (15.5); 1.7540 (16.0); 1.5963 (4.6); -0.0002 (1.0) I.1-197:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5561 (2.6); 8.5420 (4.8); 8.5278 (2.5); 8.2898 (11.9); 8.2884 (12.6); 8.2836 (12.5); 8.2821 (12.1); 7.7063 (8.7); 7.7000 (8.5); 7.6858 (10.7); 7.6795 (10.3); 7.4756 (15.5); 7.4552 (12.9); 7.3763 (1.7); 7.3727 (1.8); 7.3523 (4.0); 7.3361 (2.5); 7.3303 (4.0); 7.3098 (2.2); 7.3058 (2.0); 7.2025 (2.3); 7.1985 (2.4); 7.1896 (2.4); 7.1859 (2.9); 7.1824 (4.2); 7.1788 (4.6); 7.1698 (4.1); 7.1662 (4.6); 7.1622 (2.9); 7.1582 (2.8); 7.1493 (2.3); 7.1457 (2.5); 7.0695 (4.3); 7.0535 (5.9); 7.0501 (5.6); 7.0340 (3.1); 4.7262 (6.7); 4.6866 (7.8); 4.3084 (1.5); 4.2934 (1.5); 4.2700 (8.9); 4.2560 (16.0); 4.2423 (9.1); 4.2239 (8.6); 4.2042 (1.7); 4.1842 (7.3); 3.8354 (1.3); 3.8244 (2.8); 3.8139 (4.0); 3.8037 (4.7); 3.7936 (4.0); 3.7831 (2.9); 3.7724 (1.5); 3.3271 (164.8); 3.2779 (1.3); 3.1689 (0.7); 2.6747 (1.3); 2.6699 (1.8); 2.6654 (1.3); 2.6073 (5.9); 2.5962 (6.0); 2.5719 (7.1); 2.5608 (7.0); 2.5403 (1.1); 2.5235 (4.1); 2.5188 (6.0); 2.5102 (102.8); 2.5056 (226.1); 2.5009 (318.5); 2.4963 (221.4); 2.4917 (98.4); 2.4557 (1.5); 2.4513 (1.9); 2.4469 (1.5); 2.3916 (1.5); 2.3725 (2.0); 2.3684 (2.0); 2.3494 (4.9); 2.3276 (5.9); 2.3072 (4.0); 2.2818 (9.3); 2.2697 (5.1); 2.2594 (12.5); 2.2459 (11.4); 2.2243 (6.1); 2.2172 (3.2); 2.2041 (3.0); 2.1497 (2.0); 2.1303 (3.5); 2.1259 (2.0); 2.1181 (2.6); 2.1110 (2.1); 2.1064 (3.0); 2.0989 (4.1); 2.0942 (2.5); 2.0872 (1.6); 2.0794 (2.4); 2.0748 (3.1); 2.0628 (0.7); 2.0556 (1.3); 1.7673 (1.7); 1.7546 (2.5); 1.7435 (3.5); 1.7332 (2.9); 1.7224 (2.8); 1.7118 (3.1); 1.7011 (1.9); 1.6876 (1.3); 0.0080 (1.1); -0.0002 (35.2); -0.0085 (0.9) I.1-198:1H NMR (400.1 MHz, CDCl3): δ= 7.2684 (2.9); 7.2646 (15.8); 7.2627 (16.8); 7.2550 (1.2); 7.1357 (0.6); 7.1152 (1.4); 7.1057 (0.9); 7.1001 (0.9); 7.0941 (1.2); 7.0895 (1.7); 7.0803 (1.2); 7.0710 (1.2); 7.0595 (0.7); 7.0547 (0.7); 6.9907 (0.9); 6.9853 (1.0); 6.9804 (0.9); 6.9701 (0.7); 6.9646 (0.7); 6.0680 (0.8); 4.6967 (1.7); 4.6585 (2.0); 4.1544 (2.0); 4.1161 (1.8); 4.0200 (0.6); 4.0120 (0.8); 4.0004 (1.2); 3.9884 (0.8); 3.9807 (0.7); 3.9689 (0.3); 3.7045 (16.0); 3.5159 (0.6); 3.5021 (1.7); 3.4875 (2.7); 3.4794 (1.1); 3.4731 (1.7); 3.4595 (0.7); 2.5553 (0.4); 2.5299 (2.7); 2.5127 (3.8); 2.5004 (2.6); 2.4912 (2.4); 2.4779 (1.4); 2.4700 (1.1); 2.4542 (1.6); 2.4487 (1.2); 2.4414 (1.6); 2.4347 (1.0); 2.4248 (1.0); 2.4106 (1.1); 2.3917 (0.3); 2.3818 (0.5); 2.3679 (0.5); 2.2943 (0.4); 2.2751 (0.7); 2.2616 (0.6); 2.2552 (0.5); 2.2511 (0.6); 2.2427 (0.9); 2.2323 (0.4); 2.2227 (0.5); 2.2188 (0.6); 2.1624 (1.4); 2.1426 (1.4); 2.1259 (1.2); 2.1060 (1.1); 1.9301 (1.0); 1.8053 (0.4); 1.7932 (0.6); 1.7813 (0.8); 1.7719 (0.8); 1.7602 (0.7); 1.7581 (0.7); 1.7487 (0.6); 1.7372 (0.5); 0.0057 (0.7); 0.0019 (4.1) I.1-199:1H NMR (400.0 MHz, CDCl3): δ= 7.5218 (1.1); 7.2628 (208.2); 7.1612 (2.9); 7.1452 (3.6); 7.1407 (6.8); 7.1249 (8.2); 7.1195 (4.4); 7.1147 (2.7); 7.1111 (2.1); 7.1077 (1.9); 7.1010 (6.4); 7.0917 (2.5); 7.0886 (3.3); 7.0846 (3.8); 7.0821 (4.2); 7.0752 (6.9); 7.0686 (2.1); 7.0636 (3.0); 7.0558 (13.8); 7.0491 (12.1); 7.0455 (9.5); 7.0410 (17.0); 7.0324 (7.1); 7.0303 (6.2); 7.0206 (1.2); 7.0134 (1.0); 6.9988 (1.2); 6.8491 (3.0); 6.8467 (2.8); 6.8426 (3.6); 6.8403 (3.9); 6.8283 (4.8); 6.8266 (4.6); 6.8199 (8.8); 6.8162 (5.9); 6.8080 (3.3); 6.7994 (4.8); 6.7938 (6.2); 6.7916 (6.3); 6.7884 (3.5); 6.7851 (4.2); 6.7693 (5.1); 6.7629 (3.8); 5.5040 (3.2); 5.2997 (3.6); 4.8528 (6.6); 4.8491 (6.6); 4.8141 (7.5); 4.8104 (7.4); 4.2353 (9.8); 4.1966 (8.8); 3.9365 (1.6); 3.9254 (3.3); 3.9145 (4.1); 3.9036 (4.3); 3.8943 (4.1); 3.8834 (3.4); 3.8725 (1.6); 3.5086 (0.8); 3.4922 (3.7); 3.4841 (3.4); 3.4747 (8.1); 3.4674 (8.1); 3.4594 (7.8); 3.4518 (8.5); 3.4421 (3.6); 3.4350 (3.9); 3.4174 (0.9); 2.8232 (8.3); 2.8060 (16.0); 2.7888 (7.5); 2.5970 (6.9); 2.5862 (6.9); 2.5608 (8.1); 2.5500 (7.9); 2.5223 (1.4); 2.5037 (1.9); 2.5002 (1.8); 2.4800 (5.0); 2.4607 (4.5); 2.4573 (4.3); 2.4374 (4.2); 2.4229 (5.0); 2.4084 (5.8); 2.3988 (6.9); 2.3844 (6.9); 2.3801 (2.5); 2.3655 (2.0); 2.3558 (3.1); 2.3415 (3.1); 2.2723 (2.7); 2.2531 (4.2); 2.2484 (2.4); 2.2396 (3.2); 2.2341 (2.7); 2.2290 (3.5); 2.2206 (4.7); 2.2155 (2.9); 2.2102 (2.0); 2.2014 (2.8); 2.1962 (3.7); 2.1773 (2.1); 2.1379 (9.3); 2.1154 (9.0); 2.1017 (8.0); 2.0792 (7.9); 1.8279 (2.3); 1.8166 (2.5); 1.8139 (2.9); 1.8031 (3.4); 1.7933 (3.2); 1.7900 (2.7); 1.7839 (2.5); 1.7807 (3.1); 1.7697 (2.8); 1.7603 (2.2); 1.7572 (2.0); 1.7458 (1.8); 0.0079 (1.8); -0.0002 (56.9); -0.0085 (1.6) I.1-200:1H NMR (400.0MHz, d6-DMSO): δ= 7.1451 (2.0); 7.1250 (6.6); 7.1072 (7.4); 7.1019 (1.5); 7.0867 (2.2); 5.0355 (0.8); 5.0258 (1.0); 5.0192 (1.4); 5.0125 (0.7); 5.0043 (0.8); 4.6507 (1.9); 4.6125 (2.1); 4.0474 (2.2); 4.0092 (1.9); 3.7079 (0.7); 3.6975 (1.1); 3.6872 (1.2); 3.6770 (1.1); 3.6667 (0.7); 3.4267 (17.1); 2.6885 (1.6); 2.6784 (1.7); 2.6493 (2.1); 2.6392 (2.0); 2.5250 (0.6); 2.5202 (0.9); 2.5115 (13.2); 2.5070 (27.9); 2.5024 (37.6); 2.4978 (26.1); 2.4932 (11.7); 2.4055 (0.6); 2.4009 (2.6); 2.3797 (2.6); 2.3618 (2.2); 2.3403 (2.5); 2.2886 (1.0); 2.2749 (16.0); 2.2641 (1.6); 2.2499 (1.3); 2.2221 (0.8); 2.2084 (0.8); 2.1425 (0.6); 2.1304 (0.6); 2.1245 (0.5); 2.1177 (0.6); 2.1125 (0.8); 2.1058 (0.6); 2.0926 (0.6); 2.0861 (0.6); 1.8005 (0.6); 1.7951 (0.6); 1.7864 (1.2); 1.7684 (1.2); 1.7622 (0.8); 1.7564 (0.9); 1.7495 (0.6); 1.7177 (0.5); 1.7044 (0.6); 1.6932 (0.9); 1.6859 (0.6); 1.6823 (0.7); 1.6725 (0.7); 1.6685 (0.5); 1.6611 (0.8); 1.6502 (0.6); 1.6153 (0.6); 1.6025 (1.0); 1.5966 (1.2); 1.5887 (1.0); 1.5839 (1.1); 1.5733 (1.4); 1.5608 (1.5); 1.5521 (2.0); 1.5463 (2.3); 1.5415 (2.6); 1.5359 (1.9); 1.5315 (1.9); 1.5266 (2.1); 1.5182 (2.3); 1.5145 (2.3); 1.5066 (1.6); 1.4979 (1.1); -0.0002 (3.5) I.1-202:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.8495 (5.3); 7.3770 (3.1); 7.3732 (3.1); 7.3525 (7.5); 7.3309 (7.4); 7.3104 (4.0); 7.3064 (3.8); 7.2066 (4.2); 7.2027 (4.3); 7.1938 (4.3); 7.1866 (7.9); 7.1829 (8.2); 7.1738 (7.6); 7.1702 (8.5); 7.1664 (5.2); 7.1623 (4.8); 7.1535 (4.4); 7.1498 (4.7); 7.0695 (7.8); 7.0534 (10.9); 7.0342 (5.8); 4.7323 (12.7); 4.6930 (14.7); 4.2237 (16.0); 4.1841 (13.9); 3.8104 (2.6); 3.7998 (5.3); 3.7890 (7.3); 3.7790 (9.9); 3.7690 (7.4); 3.7586 (5.8); 3.7477 (2.6); 3.3210 (402.5); 3.1678 (1.1); 2.6741 (2.5); 2.6695 (3.6); 2.6650 (2.4); 2.5411 (80.2); 2.5296 (86.2); 2.5231 (10.4); 2.5183 (12.4); 2.5096 (208.9); 2.5051 (453.5); 2.5005 (641.2); 2.4959 (442.0); 2.4913 (200.8); 2.4649 (13.8); 2.4531 (13.1); 2.3966 (3.4); 2.3776 (4.3); 2.3549 (9.9); 2.3359 (9.2); 2.3320 (10.4); 2.3226 (3.3); 2.3128 (7.4); 2.2815 (7.5); 2.2680 (9.1); 2.2574 (11.2); 2.2441 (10.8); 2.2263 (3.7); 2.2154 (5.8); 2.2024 (5.9); 2.1860 (13.8); 2.1647 (13.5); 2.1509 (11.6); 2.1454 (5.0); 2.1294 (12.4); 2.1138 (5.2); 2.1067 (4.3); 2.1022 (5.9); 2.0945 (8.4); 2.0899 (4.9); 2.0828 (3.0); 2.0750 (4.7); 2.0705 (6.4); 2.0509 (2.8); 1.7555 (3.4); 1.7428 (5.0); 1.7320 (6.9); 1.7215 (5.5); 1.7108 (5.5); 1.7002 (6.1); 1.6896 (3.8); 1.6764 (2.6); 0.0080 (3.7); -0.0002 (124.4); -0.0086 (3.4) I.1-203:1H NMR (400.0MHz, d6-DMSO): δ= 7.1470 (1.8); 7.1266 (7.0); 7.1130 (7.8); 7.1073 (1.4); 7.0923 (1.9); 5.9126 (0.6); 5.8987 (1.2); 5.8860 (0.8); 5.8726 (1.4); 5.8695 (0.7); 5.8587 (0.7); 5.8557 (1.5); 5.8429 (0.9); 5.8295 (1.5); 5.8157 (0.7); 5.2970 (0.8); 5.2930 (2.3); 5.2888 (2.4); 5.2847 (0.8); 5.2539 (0.7); 5.2498 (2.0); 5.2457 (2.1); 5.2416 (0.7); 5.2203 (0.9); 5.2169 (2.2); 5.2131 (2.0); 5.2097 (0.8); 5.1941 (0.8); 5.1908 (2.0); 5.1869 (1.8); 5.1835 (0.7); 4.6592 (1.9); 4.6210 (2.2); 4.5164 (2.5); 4.5129 (4.3); 4.5093 (2.5); 4.5026 (2.4); 4.4991 (4.1); 4.4956 (2.3); 4.0594 (2.2); 4.0213 (2.0); 3.7317 (0.8); 3.7212 (1.1); 3.7107 (1.2); 3.7003 (1.1); 3.6899 (0.8); 3.5667 (6.1); 2.7983 (1.5); 2.7882 (1.5); 2.7584 (1.9); 2.7484 (1.8); 2.5204 (0.6); 2.5118 (7.8); 2.5073 (16.4); 2.5027 (22.1); 2.4981 (15.3); 2.4935 (6.9); 2.4862 (2.2); 2.4641 (2.0); 2.4463 (2.0); 2.4242 (1.9); 2.4040 (1.1); 2.3859 (0.8); 2.3804 (0.8); 2.3623 (0.8); 2.2892 (1.0); 2.2753 (16.0); 2.2648 (1.6); 2.2511 (1.2); 2.2229 (0.8); 2.2097 (0.8); 2.1511 (0.7); 2.1386 (0.6); 2.1326 (0.5); 2.1262 (0.6); 2.1201 (0.8); 2.1142 (0.6); 2.1006 (0.5); 2.0948 (0.6); 1.7136 (0.6); 1.7024 (0.9); 1.6944 (0.6); 1.6914 (0.7); 1.6820 (0.7); 1.6782 (0.5); 1.6705 (0.8); -0.0002 (3.3) I.1-204:1H NMR (400.0MHz, d6-DMSO): δ= 7.6224 (0.5); 7.6098 (4.0); 7.6044 (4.2); 7.4073 (1.9); 7.4018 (1.8); 7.3864 (2.4); 7.3810 (2.4); 7.2661 (3.0); 7.2453 (2.3); 4.6184 (1.7); 4.5776 (2.0); 4.2290 (1.9); 4.1881 (1.6); 4.0262 (0.5); 3.9644 (0.8); 3.8024 (0.9); 3.7917 (1.5); 3.7799 (2.2); 3.7387 (16.0); 3.1685 (10.4); 2.6701 (0.5); 2.5404 (1.4); 2.5304 (1.5); 2.5236 (1.6); 2.5189 (2.3); 2.5102 (30.2); 2.5056 (64.5); 2.5010 (89.1); 2.4963 (62.4); 2.4918 (28.7); 2.3915 (0.9); 2.3730 (0.8); 2.3693 (0.7); 2.3509 (0.6); 2.3278 (0.6); 2.2839 (0.6); 2.2709 (0.7); 2.2597 (1.0); 2.2468 (1.1); 2.2233 (1.4); 2.2184 (0.8); 2.2068 (0.8); 2.2005 (1.5); 2.1858 (1.7); 2.1737 (0.5); 2.1671 (0.5); 2.1628 (1.4); 2.1551 (0.8); 1.7764 (0.6); 1.7651 (0.7); 1.7545 (0.6); 1.7467 (0.7); 1.7343 (0.6); -0.0002 (9.3) I.1-205:1H NMR (400.0 MHz, i.e6-DMSO): δ= 11.7795 (1.4); 7.5926 (1.1); 7.5890 (1.1); 7.5726 (1.3); 7.5689 (1.2); 7.3775 (1.3); 7.3579 (2.5); 7.3381 (1.4); 7.1927 (1.1); 7.1892 (1.1); 7.1733 (1.0); 7.1697 (0.9); 4.6722 (1.1); 4.6304 (1.3); 4.2906 (1.2); 4.2489 (1.0); 3.8733 (0.6); 3.8627 (0.5); 3.3634 (36.0); 3.1854 (16.0); 3.1683 (5.1); 2.7287 (0.7); 2.7183 (0.7); 2.6905 (1.0); 2.6799 (1.0); 2.6697 (0.5); 2.5232 (1.1); 2.5184 (1.7); 2.5099 (27.0); 2.5053 (57.5); 2.5006 (78.5); 2.4960 (54.6); 2.4914 (24.6); 2.4601 (1.0); 2.4382 (1.2); 2.4219 (0.9); 2.4152 (0.7); 2.4002 (0.8); 2.3326 (0.6); 2.3274 (0.6); 2.3220 (0.9); 2.3100 (0.7); 2.2818 (1.0); 2.2727 (0.7); 2.2457 (0.6); - 0.0002 (3.3) I.1-206:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1480 (1.1); 7.1418 (1.1); 7.1276 (4.4); 7.1151 (4.6); 7.0944 (1.0); 7.0860 (1.6); 7.0660 (0.8); 4.7054 (1.0); 4.6673 (1.2); 4.1760 (2.2); 4.0472 (1.2); 4.0338 (6.3); 4.0087 (1.0); 3.9820 (0.5); 3.7219 (0.6); 3.7106 (0.6); 3.7008 (0.5); 3.6718 (7.4); 3.6171 (16.0); 3.3633 (0.9); 3.3152 (206.8); 3.2658 (1.7); 3.1682 (0.8); 2.9415 (15.3); 2.8031 (0.6); 2.7936 (0.7); 2.7656 (5.4); 2.7534 (0.8); 2.6743 (1.0); 2.6695 (1.6); 2.6649 (1.2); 2.6601 (0.6); 2.5500 (0.6); 2.5453 (0.5); 2.5398 (0.8); 2.5230 (3.1); 2.5183 (4.8); 2.5096 (86.8); 2.5050 (193.2); 2.5004 (272.7); 2.4958 (189.3); 2.4912 (84.6); 2.4671 (1.1); 2.4606 (1.6); 2.4552 (1.5); 2.4505 (1.8); 2.4455 (1.7); 2.4208 (0.9); 2.3967 (0.6); 2.3318 (1.4); 2.3273 (1.7); 2.3226 (1.2); 2.3177 (0.7); 2.2750 (10.6); 2.2587 (0.6); 2.2461 (0.6); 2.2346 (0.7); 2.2221 (0.7); 2.0716 (1.1); -0.0002 (16.0) I.1-207:1H NMR (400.1 MHz, d6-DMSO): δ= 8.2967 (1.1); 8.2902 (1.2); 8.2747 (1.2); 8.2688 (1.2); 7.3913 (0.4); 7.3861 (0.3); 7.3703 (1.0); 7.3654 (0.9); 7.3499 (1.0); 7.3453 (1.1); 7.3297 (0.4); 7.3246 (0.6); 7.2223 (0.6); 7.2025 (1.2); 7.1900 (1.3); 7.1862 (1.1); 7.1821 (0.9); 7.1697 (0.8); 7.1151 (0.8); 7.1036 (1.1); 7.0988 (1.2); 7.0946 (1.2); 7.0785 (2.0); 7.0588 (2.4); 6.9965 (2.2); 6.9775 (1.5); 6.8658 (1.9); 6.8477 (2.0); 4.8415 (0.8); 4.8195 (1.7); 4.7935 (2.4); 4.7526 (2.1); 4.2962 (1.2); 4.2812 (1.3); 4.2566 (1.1); 4.2410 (1.1); 3.8952 (0.4); 3.8852 (0.7); 3.8750 (1.0); 3.8654 (1.1); 3.8546 (1.0); 3.8454 (0.8); 3.8351 (0.5); 3.3681 (1.0); 3.3188 (110.0); 3.1684 (1.5); 2.9753 (1.1); 2.9560 (1.2); 2.9370 (1.4); 2.9174 (1.3); 2.6740 (0.5); 2.6695 (0.7); 2.6620 (1.0); 2.6512 (0.8); 2.6402 (0.8); 2.6285 (1.6); 2.6172 (1.0); 2.6057 (1.0); 2.5945 (0.9); 2.5547 (0.6); 2.5502 (0.9); 2.5456 (0.8); 2.5397 (0.9); 2.5229 (1.6); 2.5182 (2.3); 2.5097 (37.1); 2.5051 (81.0); 2.5005 (113.2); 2.4960 (84.2); 2.4915 (43.1); 2.4527 (1.1); 2.4481 (0.7); 2.4388 (0.9); 2.4158 (1.5); 2.4095 (1.6); 2.3970 (1.4); 2.3908 (1.1); 2.3778 (1.6); 2.3548 (0.8); 2.3446 (1.2); 2.3360 (0.9); 2.3322 (0.9); 2.3270 (1.2); 2.3229 (2.4); 2.3166 (1.6); 2.3103 (2.0); 2.2985 (1.9); 2.2942 (1.6); 2.2885 (1.4); 2.2823 (1.6); 2.2691 (0.9); 2.2521 (16.0); 2.2295 (1.0); 2.2180 (0.7); 2.2065 (0.8); 2.1985 (0.7); 2.1891 (1.0); 2.1742 (1.2); 2.1657 (1.1); 2.1543 (1.4); 2.1331 (1.1); 2.1139 (0.5); 2.0718 (0.4); 1.9069 (0.4); 1.8954 (0.5); 1.8766 (0.6); 1.8659 (0.7); 1.8553 (0.7); 1.8445 (0.6); 1.8241 (0.4); 1.1273 (6.0); 1.1215 (6.2); 1.1106 (6.2); 1.1048 (6.0) I.1-210:1H NMR (400.1 MHz, i.e6-DMSO): δ= 7.4204 (3.6); 7.3992 (7.5); 7.3934 (4.3); 7.3780 (4.5); 7.3722 (7.7); 7.3510 (3.9); 7.2972 (3.4); 7.2920 (3.6); 7.2775 (3.6); 7.2719 (4.3); 7.2684 (4.3); 7.2629 (3.9); 7.2485 (3.4); 7.2435 (3.6); 7.2038 (6.0); 7.0960 (3.9); 7.0902 (4.1); 7.0853 (4.2); 7.0721 (16.0); 6.9406 (6.4); 4.5633 (7.8); 4.5240 (9.6); 4.3451 (0.3); 4.1739 (9.8); 4.1513 (0.4); 4.1347 (8.2); 3.8432 (1.4); 3.8321 (2.9); 3.8214 (4.3); 3.8111 (5.1); 3.8011 (4.5); 3.7907 (3.3); 3.7800 (1.7); 2.8080 (5.0); 2.7975 (5.3); 2.7682 (6.5); 2.7578 (6.5); 2.6695 (0.5); 2.5100 (31.3); 2.5057 (73.6); 2.5011 (108.0); 2.4966 (82.5); 2.4922 (42.2); 2.4658 (7.5); 2.4437 (7.2); 2.4259 (6.3); 2.4167 (3.0); 2.4040 (6.2); 2.3988 (6.3); 2.3801 (4.6); 2.3753 (4.4); 2.3570 (4.0); 2.3326 (0.7); 2.3283 (0.8); 2.3105 (3.3); 2.2970 (3.8); 2.2863 (5.1); 2.2727 (5.3); 2.2558 (1.5); 2.2445 (3.0); 2.2318 (3.3); 2.2103 (2.2); 2.1922 (3.2); 2.1795 (2.6); 2.1734 (2.5); 2.1677 (2.6); 2.1608 (4.0); 2.1493 (1.8); 2.1414 (2.4); 2.1364 (2.8); 2.1174 (1.3); 2.0715 (1.2); 1.7357 (1.5); 1.7241 (2.8); 1.7127 (3.4); 1.7016 (3.3); 1.6924 (3.4); 1.6809 (3.2); 1.6694 (2.3); 1.6566 (1.6); 0.0084 (0.4); 0.0000 (21.2) I.1-211:1H NMR (400.0MHz, CDCl3): δ= 7.2626 (43.0); 7.0969 (1.1); 7.0845 (0.7); 7.0813 (0.7); 7.0783 (0.8); 7.0703 (1.2); 7.0583 (0.6); 7.0541 (1.3); 7.0505 (2.4); 7.0434 (2.9); 7.0403 (1.9); 7.0349 (3.1); 7.0245 (1.4); 6.7513 (3.3); 6.7316 (4.4); 6.6546 (3.1); 6.6508 (3.6); 6.6154 (2.2); 6.6111 (1.9); 6.5958 (1.7); 6.5914 (1.5); 5.9379 (2.2); 5.9339 (16.0); 5.9301 (2.2); 5.4159 (0.7); 5.2995 (3.0); 4.8498 (1.4); 4.8463 (1.3); 4.8111 (1.5); 4.8074 (1.5); 4.2272 (2.0); 4.1885 (1.7); 3.9359 (0.7); 3.9249 (0.8); 3.9146 (0.9); 3.9049 (0.8); 3.8940 (0.7); 3.4826 (0.8); 3.4654 (1.8); 3.4502 (2.8); 3.4350 (1.7); 3.4183 (0.8); 2.7252 (2.4); 2.7080 (4.8); 2.6908 (2.2); 2.5840 (1.4); 2.5730 (1.4); 2.5479 (1.6); 2.5369 (1.6); 2.4781 (1.0); 2.4589 (0.9); 2.4554 (0.8); 2.4358 (0.8); 2.4218 (1.0); 2.4072 (1.2); 2.3977 (1.4); 2.3833 (1.4); 2.3790 (0.5); 2.3547 (0.6); 2.3405 (0.6); 2.2785 (0.6); 2.2594 (0.8); 2.2546 (0.5); 2.2459 (0.6); 2.2404 (0.5); 2.2353 (0.7); 2.2269 (0.9); 2.2219 (0.6); 2.2077 (0.6); 2.2026 (0.7); 2.1274 (1.8); 2.1051 (1.8); 2.0913 (1.6); 2.0691 (1.5); 1.8164 (0.6); 1.8055 (0.7); 1.7958 (0.6); 1.7926 (0.5); 1.7865 (0.5); 1.7834 (0.6); 1.7723 (0.6); -0.0002 (12.1) I.1-212:1H NMR (400.0MHz, d6-DMSO): δ= 7.1480 (2.0); 7.1277 (7.2); 7.1122 (7.9); 7.1068 (1.5); 7.0916 (2.1); 4.7365 (0.6); 4.7280 (0.6); 4.7208 (1.3); 4.7124 (1.2); 4.7051 (1.3); 4.6967 (1.2); 4.6894 (0.7); 4.6810 (0.6); 4.6688 (1.5); 4.6307 (1.7); 4.0492 (2.3); 4.0111 (2.0); 3.7159 (0.7); 3.7054 (1.0); 3.6952 (1.1); 3.6846 (1.0); 3.6741 (0.7); 3.4042 (86.0); 3.3688 (1.4); 2.7392 (0.9); 2.7321 (1.0); 2.7295 (1.1); 2.7224 (0.9); 2.7002 (1.2); 2.6931 (1.3); 2.6904 (1.3); 2.6835 (1.1); 2.6716 (0.5); 2.5250 (1.4); 2.5203 (1.9); 2.5116 (27.8); 2.5071 (59.4); 2.5025 (81.5); 2.4979 (57.9); 2.4933 (26.4); 2.4090 (1.5); 2.4030 (1.4); 2.3947 (0.9); 2.3870 (1.3); 2.3807 (1.5); 2.3701 (1.6); 2.3641 (1.2); 2.3482 (1.2); 2.3418 (1.0); 2.3292 (0.5); 2.2920 (0.7); 2.2750 (16.0); 2.2533 (1.1); 2.2277 (0.6); 2.2254 (0.5); 2.2137 (0.6); 2.1683 (0.5); 2.1490 (0.7); 2.1367 (0.6); 2.1310 (0.5); 2.1242 (0.6); 2.1175 (0.8); 2.1123 (0.6); 2.0990 (0.5); 2.0928 (0.6); 1.7130 (0.5); 1.7000 (0.8); 1.6887 (0.8); 1.6787 (0.6); 1.6681 (0.8); 1.6565 (0.6); 1.4960 (1.3); 1.4889 (1.8); 1.4796 (1.7); 1.4770 (1.7); 1.4730 (2.0); 1.4703 (2.0); 1.4612 (1.7); 1.4544 (1.9); 1.4427 (0.6); 1.4361 (0.6); 1.1209 (8.4); 1.1172 (7.9); 1.1052 (8.4); 1.1015 (7.8); 0.8241 (5.4); 0.8056 (11.0); 0.7869 (4.8); -0.0002 (9.1) I.1-213:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.7544 (1.1); 7.7339 (1.2); 7.3757 (0.5); 7.3553 (1.2); 7.3338 (1.2); 7.3127 (0.6); 7.2094 (0.6); 7.2062 (0.6); 7.1895 (1.2); 7.1857 (1.2); 7.1735 (1.3); 7.1655 (0.7); 7.1533 (0.7); 7.0772 (1.2); 7.0611 (1.7); 7.0419 (0.9); 4.7378 (1.9); 4.6981 (2.2); 4.2415 (2.3); 4.2015 (1.9); 3.8041 (0.8); 3.7940 (1.1); 3.7838 (1.4); 3.7734 (1.1); 3.7636 (0.8); 3.6535 (0.6); 3.6441 (0.8); 3.6371 (0.8); 3.6238 (0.9); 3.6075 (0.7); 3.3135 (89.5); 3.2626 (0.7); 2.6698 (0.7); 2.5232 (1.8); 2.5185 (2.5); 2.5099 (41.1); 2.5053 (91.2); 2.5007 (127.6); 2.4960 (88.7); 2.4915 (40.6); 2.4804 (1.6); 2.4699 (1.5); 2.4579 (2.5); 2.4509 (1.2); 2.4461 (1.9); 2.4012 (0.5); 2.3799 (0.6); 2.3589 (1.4); 2.3365 (1.5); 2.3274 (0.9); 2.3227 (0.7); 2.3174 (1.3); 2.2917 (0.7); 2.2866 (0.7); 2.2784 (0.8); 2.2733 (0.9); 2.2679 (1.0); 2.2626 (1.0); 2.2544 (1.0); 2.2495 (1.2); 2.2259 (0.5); 2.2206 (0.6); 2.2126 (0.5); 2.1874 (1.3); 2.1837 (1.4); 2.1660 (1.4); 2.1624 (1.4); 2.1530 (1.2); 2.1491 (1.2); 2.1315 (1.2); 2.1274 (1.7); 2.1138 (0.7); 2.1020 (0.9); 2.0945 (1.2); 2.0707 (0.9); 1.7666 (0.5); 1.7585 (0.7); 1.7534 (0.7); 1.7453 (0.8); 1.7270 (0.7); 1.7217 (0.6); 1.3839 (0.8); 1.3651 (2.8); 1.3583 (1.2); 1.3467 (3.4); 1.3400 (1.8); 1.3299 (2.6); 1.3218 (1.3); 1.3116 (0.8); 0.9915 (16.0); 0.9749 (15.7); 0.8150 (4.3); 0.8118 (4.5); 0.7966 (9.0); 0.7934 (9.5); 0.7779 (3.8); 0.7747 (3.8); -0.0002 (12.0) I.1-215:1H NMR (400.1 MHz, d6-DMSO): δ= 11.7858 (1.4); 7.4255 (0.6); 7.4043 (1.2); 7.3985 (0.6); 7.3832 (0.7); 7.3773 (1.2); 7.3562 (0.6); 7.2958 (0.5); 7.2907 (0.5); 7.2762 (0.5); 7.2708 (0.6); 7.2670 (0.6); 7.2616 (0.6); 7.2471 (0.5); 7.2420 (0.5); 7.0958 (0.6); 7.0915 (0.6); 7.0861 (0.6); 7.0807 (0.6); 7.0752 (0.5); 7.0700 (0.5); 7.0647 (0.5); 4.5877 (1.2); 4.5485 (1.4); 4.1494 (1.5); 4.1102 (1.2); 3.8330 (0.5); 3.8226 (0.6); 3.8123 (0.8); 3.8023 (0.6); 3.7919 (0.5); 3.3743 (0.8); 3.3232 (238.2); 3.2740 (1.2); 3.2174 (16.0); 2.7224 (0.9); 2.7114 (0.9); 2.6839 (1.2); 2.6729 (1.3); 2.6661 (0.4); 2.5238 (1.0); 2.5191 (1.4); 2.5104 (23.6); 2.5059 (51.0); 2.5014 (70.2); 2.4968 (49.8); 2.4924 (23.3); 2.4522 (0.3); 2.4134 (0.4); 2.4084 (0.4); 2.3899 (0.9); 2.3843 (1.2); 2.3714 (0.8); 2.3627 (1.3); 2.3462 (1.3); 2.3328 (0.4); 2.3240 (1.2); 2.3136 (0.6); 2.2999 (0.6); 2.2894 (0.8); 2.2759 (0.8); 2.2476 (0.4); 2.2347 (0.5); 2.2070 (0.3); 2.1883 (0.5); 2.1759 (0.4); 2.1693 (0.3); 2.1642 (0.4); 2.1569 (0.6); 2.1521 (0.4); 2.1374 (0.4); 2.1327 (0.4); 1.7440 (0.4); 1.7323 (0.5); 1.7216 (0.5); 1.7121 (0.5); 1.7006 (0.5); 1.6894 (0.3) I.1-216:1H NMR (400.0 MHz, i.e6-DMSO): δ= 10.8459 (3.1); 8.3318 (2.1); 8.3199 (2.3); 8.3119 (2.4); 8.3003 (2.0); 7.5429 (4.2); 7.5234 (4.5); 7.3425 (4.4); 7.3242 (4.7); 7.3223 (5.1); 7.1327 (8.3); 7.1148 (6.8); 7.0912 (8.1); 7.0857 (5.9); 7.0798 (6.5); 7.0708 (5.3); 7.0681 (5.4); 7.0475 (2.8); 7.0446 (2.2); 7.0064 (5.3); 6.9972 (3.9); 6.9945 (3.2); 6.9865 (4.0); 6.9797 (4.2); 6.9774 (4.5); 6.9599 (2.1); 6.9573 (1.6); 4.6282 (2.0); 4.5910 (2.6); 4.5590 (2.0); 4.5299 (0.7); 4.5176 (0.9); 4.5069 (1.6); 4.4945 (1.7); 4.4866 (1.6); 4.4742 (1.6); 4.4633 (0.8); 4.4511 (0.6); 4.0140 (2.3); 3.9760 (2.1); 3.8852 (2.2); 3.8468 (2.1); 3.6247 (2.2); 3.6155 (2.6); 3.6061 (2.6); 3.4574 (1.8); 3.3587 (85.4); 3.1993 (1.8); 3.1872 (1.9); 3.1628 (2.5); 3.1513 (2.2); 3.0152 (1.7); 3.0083 (1.8); 2.9923 (1.8); 2.9850 (2.0); 2.9716 (1.5); 2.9560 (1.4); 2.9487 (1.4); 2.6821 (1.3); 2.6777 (1.2); 2.6125 (1.2); 2.5696 (1.3); 2.5653 (1.3); 2.5607 (1.2); 2.5218 (28.5); 2.5176 (57.4); 2.5131 (77.1); 2.5087 (60.2); 2.4910 (2.6); 2.4852 (2.5); 2.4729 (2.3); 2.4679 (2.6); 2.4569 (2.1); 2.3444 (0.8); 2.3398 (0.9); 2.3355 (0.8); 2.3233 (0.8); 2.3017 (1.5); 2.2754 (16.0); 2.2670 (14.9); 2.2391 (2.2); 2.2173 (1.2); 2.2049 (1.0); 2.1911 (1.3); 2.1863 (1.4); 2.1809 (1.5); 2.1631 (2.8); 2.1484 (1.8); 2.1386 (2.7); 2.1301 (2.0); 2.1154 (1.9); 2.1066 (2.1); 2.0968 (1.2); 2.0809 (1.3); 1.9159 (0.7); 1.9036 (0.6); 1.8926 (0.8); 1.8842 (0.9); 1.8604 (0.8); 1.7975 (0.7); 1.7855 (0.6); 1.7741 (0.8); 1.7661 (0.9); 1.7548 (0.5); 1.7423 (0.8); 1.6739 (0.6); 1.6635 (0.8); 1.6528 (0.8); 1.6410 (0.8); 1.6316 (0.6); 1.4291 (0.6); 1.4184 (0.8); 1.4079 (0.8); 1.3959 (0.8); 1.3863 (0.7) I.1-217:1H NMR (400.0MHz, d6-DMSO): δ= 7.2307 (0.7); 7.2119 (1.7); 7.1932 (1.1); 7.0820 (0.9); 7.0633 (0.7); 7.0176 (1.5); 6.9864 (0.7); 4.6545 (1.1); 4.6165 (1.2); 4.0623 (1.2); 4.0238 (1.0); 3.7354 (0.6); 3.7251 (0.6); 3.7148 (0.6); 3.5531 (16.0); 3.3851 (15.2); 3.1671 (0.5); 2.7551 (0.8); 2.7448 (0.9); 2.7152 (1.1); 2.7049 (1.0); 2.6787 (0.6); 2.6742 (1.2); 2.6697 (1.7); 2.6651 (1.2); 2.5554 (0.6); 2.5506 (0.8); 2.5459 (0.6); 2.5404 (0.6); 2.5231 (4.7); 2.5184 (7.2); 2.5098 (95.0); 2.5052 (203.8); 2.5006 (283.6); 2.4960 (198.0); 2.4914 (87.9); 2.4599 (1.4); 2.4380 (1.2); 2.4202 (1.1); 2.4050 (0.7); 2.3981 (1.1); 2.3855 (0.5); 2.3625 (0.6); 2.3367 (0.6); 2.3320 (1.3); 2.3274 (1.8); 2.3227 (1.3); 2.3009 (0.6); 2.2845 (8.5); 2.2769 (1.2); 2.2633 (0.8); 2.1330 (0.5); 1.7031 (0.5); 0.0080 (4.1); -0.0002 (142.6); -0.0086 (4.3) I.1-218:1H NMR (400.0MHz, d6-DMSO): δ= 7.3802 (0.8); 7.3589 (1.0); 7.2565 (0.8); 7.2352 (0.6); 3.5497 (0.5); 3.4606 (16.0); 3.1678 (0.7); 2.5230 (1.1); 2.5182 (1.5); 2.5096 (21.0); 2.5050 (44.9); 2.5003 (61.6); 2.4957 (42.8); 2.4911 (19.2); 2.0719 (0.5); -0.0002 (6.9) I.1-220:1H NMR (400.0MHz, d6-DMSO): δ= 8.2646 (2.0); 8.2447 (2.0); 7.2287 (1.8); 7.2244 (2.1); 7.2142 (4.7); 7.2107 (6.7); 7.1978 (1.0); 7.1749 (1.1); 7.1689 (1.0); 7.1561 (2.2); 7.1491 (2.0); 7.1421 (1.5); 7.1350 (2.1); 7.1305 (2.8); 7.1274 (3.0); 7.1096 (1.1); 4.7649 (2.4); 4.7258 (2.7); 4.1878 (0.7); 4.1726 (0.9); 4.1677 (1.0); 4.1525 (1.2); 4.1456 (0.8); 4.1303 (0.8); 4.0616 (2.3); 4.0225 (2.1); 3.6751 (0.7); 3.6538 (1.2); 3.6323 (0.8); 3.6231 (0.6); 3.4737 (3.5); 3.1671 (4.5); 2.6753 (0.8); 2.6707 (1.1); 2.6661 (0.8); 2.6280 (1.0); 2.6094 (3.0); 2.6053 (3.0); 2.5904 (3.0); 2.5865 (3.1); 2.5729 (1.9); 2.5680 (1.8); 2.5641 (1.8); 2.5409 (0.8); 2.5282 (1.1); 2.5241 (2.4); 2.5195 (4.0); 2.5107 (60.6); 2.5062 (132.6); 2.5016 (185.3); 2.4970 (131.7); 2.4925 (59.6); 2.4777 (2.1); 2.4730 (2.5); 2.4684 (2.6); 2.4637 (1.8); 2.4519 (1.2); 2.4471 (0.8); 2.4158 (1.0); 2.3957 (0.9); 2.3739 (1.6); 2.3507 (0.8); 2.3330 (0.8); 2.3284 (1.2); 2.3238 (0.8); 2.2908 (0.9); 2.2807 (1.0); 2.2669 (1.2); 2.2565 (1.3); 2.2493 (0.8); 2.2380 (2.1); 2.2249 (0.8); 2.2142 (2.1); 2.2035 (1.4); 2.1796 (1.3); 2.0753 (0.6); 2.0400 (0.7); 2.0312 (0.6); 2.0189 (0.8); 2.0082 (1.0); 1.9876 (0.9); 1.8408 (0.7); 1.8325 (0.6); 1.8276 (0.6); 1.8185 (1.0); 1.8087 (1.0); 1.8000 (0.5); 1.7867 (0.5); 1.6149 (0.6); 1.5949 (0.8); 1.5788 (0.8); 1.5626 (0.6); 1.5055 (1.5); 1.4974 (1.8); 1.4929 (1.5); 1.4825 (2.8); 1.4752 (1.4); 1.4690 (1.4); 1.4610 (1.3); 1.1430 (7.0); 1.1242 (16.0); 1.1053 (6.9); 0.8940 (10.2); 0.8777 (9.9); 0.8258 (10.3); 0.8096 (10.1); 0.0080 (0.7); -0.0002 (24.4); -0.0086 (0.8) I.1-222:1H NMR (400.0MHz, d6-DMSO): δ= 7.8299 (5.8); 7.2391 (0.9); 7.2204 (2.2); 7.2016 (1.4); 7.0863 (1.5); 7.0669 (1.2); 7.0496 (2.0); 7.0377 (1.4); 7.0169 (1.4); 4.7144 (1.2); 4.6758 (1.3); 4.0840 (1.4); 4.0455 (1.3); 3.8412 (0.6); 3.8307 (0.7); 3.8190 (0.8); 3.8091 (0.7); 3.7989 (0.6); 3.5921 (16.0); 2.8641 (0.5); 2.8543 (0.5); 2.8273 (0.7); 2.8175 (0.6); 2.7662 (2.0); 2.7539 (2.0); 2.5236 (0.5); 2.5189 (0.9); 2.5102 (17.6); 2.5057 (38.7); 2.5011 (54.4); 2.4965 (39.0); 2.4919 (18.3); 2.4683 (1.0); 2.4647 (1.0); 2.4512 (0.5); 2.4433 (1.0); 2.4210 (0.9); 2.4020 (0.8); 2.3978 (0.8); 2.3790 (0.7); 2.3325 (0.8); 2.3280 (0.5); 2.3190 (0.8); 2.3082 (0.9); 2.2875 (12.1); 2.2664 (0.6); 2.2534 (0.6); 2.1821 (0.6); 2.1580 (0.6); 2.1509 (0.7); 2.1458 (0.5); 2.1264 (0.6); 2.0732 (1.3); 1.8203 (0.6); 1.8104 (0.5); 1.7996 (0.6); 1.7887 (0.6); 1.7778 (0.5); 1.0710 (0.8); 1.0530 (1.7); 1.0350 (0.7); 0.0080 (0.5); -0.0002 (17.6); -0.0085 (0.6) I.1-225:1H NMR (400.0MHz, d6-DMSO): δ= 10.7955 (4.3); 8.0700 (2.2); 8.0560 (4.4); 8.0419 (2.1); 7.5174 (6.1); 7.4975 (6.5); 7.3808 (1.2); 7.3768 (1.3); 7.3603 (2.6); 7.3563 (2.9); 7.3502 (1.7); 7.3358 (10.9); 7.3338 (8.2); 7.3179 (6.5); 7.3157 (10.7); 7.3135 (7.3); 7.2085 (1.5); 7.2046 (1.7); 7.1958 (1.7); 7.1918 (2.0); 7.1885 (2.9); 7.1849 (3.1); 7.1757 (2.8); 7.1724 (3.2); 7.1683 (2.0); 7.1644 (1.9); 7.1555 (1.6); 7.1519 (1.7); 7.1238 (9.0); 7.1181 (8.7); 7.0747 (5.0); 7.0718 (6.0); 7.0571 (7.9); 7.0545 (11.1); 7.0519 (7.4); 7.0371 (6.2); 7.0343 (6.2); 6.9827 (5.5); 6.9800 (5.8); 6.9651 (5.0); 6.9628 (8.4); 6.9604 (6.2); 6.9455 (3.9); 6.9429 (3.7); 4.7400 (4.5); 4.7002 (5.2); 4.2323 (5.6); 4.1926 (4.9); 3.8159 (0.9); 3.8051 (1.8); 3.7946 (2.6); 3.7845 (3.3); 3.7745 (2.6); 3.7641 (1.8); 3.7534 (0.9); 3.4882 (16.0); 3.3360 (2.3); 3.3204 (5.3); 3.3028 (5.5); 3.2865 (2.8); 3.1700 (0.5); 2.8030 (5.9); 2.7837 (8.9); 2.7663 (5.1); 2.6704 (0.5); 2.5405 (0.6); 2.5190 (5.3); 2.5104 (30.4); 2.5059 (66.3); 2.5012 (90.3); 2.4966 (62.8); 2.4920 (28.2); 2.4843 (5.1); 2.4726 (4.3); 2.3874 (1.0); 2.3675 (1.5); 2.3644 (1.5); 2.3450 (3.2); 2.3256 (3.2); 2.3028 (2.5); 2.2718 (2.4); 2.2584 (2.9); 2.2477 (3.6); 2.2344 (3.5); 2.2166 (1.4); 2.2058 (2.1); 2.1980 (4.8); 2.1928 (2.4); 2.1765 (4.4); 2.1631 (3.8); 2.1416 (3.7); 2.1179 (1.2); 2.0984 (2.2); 2.0941 (1.4); 2.0862 (1.7); 2.0791 (1.5); 2.0744 (2.2); 2.0668 (2.7); 2.0623 (1.7); 2.0551 (1.0); 2.0472 (1.5); 2.0428 (2.1); 2.0232 (0.9); 1.7426 (1.2); 1.7299 (1.7); 1.7191 (2.4); 1.7089 (2.1); 1.6975 (2.1); 1.6872 (2.1); 1.6767 (1.2); 1.6636 (0.9); -0.0002 (8.2) I.1-226:1H NMR (400.1 MHz, i.e6-DMSO): δ= 12.3354 (1.1); 7.6245 (15.2); 7.6192 (16.0); 7.4172 (6.9); 7.4119 (6.6); 7.3964 (9.3); 7.3911 (9.1); 7.2838 (13.5); 7.2629 (10.0); 4.6530 (8.3); 4.6123 (10.0); 4.2473 (9.3); 4.2065 (7.8); 3.8069 (1.2); 3.7965 (2.4); 3.7861 (3.7); 3.7762 (4.2); 3.7658 (3.8); 3.7554 (3.0); 3.7449 (1.1); 3.3368 (8.3); 2.6737 (0.3); 2.6690 (0.4); 2.6569 (5.2); 2.6465 (5.3); 2.6170 (7.0); 2.6067 (6.7); 2.5393 (0.4); 2.5224 (0.9); 2.5091 (19.8); 2.5047 (41.9); 2.5002 (58.2); 2.4957 (42.5); 2.4912 (20.6); 2.4688 (1.8); 2.4512 (1.9); 2.4410 (1.2); 2.4276 (4.6); 2.4115 (9.9); 2.4046 (3.8); 2.3899 (8.3); 2.3719 (5.8); 2.3500 (5.3); 2.3315 (0.4); 2.3270 (0.5); 2.3135 (2.5); 2.3011 (2.6); 2.2891 (4.5); 2.2768 (4.7); 2.2486 (8.4); 2.2391 (5.2); 2.2303 (2.8); 2.2247 (2.2); 2.2194 (1.2); 2.2123 (3.6); 2.2063 (1.6); 2.2003 (1.1); 2.1931 (2.0); 2.1876 (2.0); 2.1688 (1.0); 1.8062 (0.9); 1.7824 (3.3); 1.7715 (2.9); 1.7611 (3.2); 1.7536 (2.0); 1.7482 (2.0); 1.7447 (2.0); 1.7403 (2.2); 1.7290 (2.2); 1.7171 (1.2); 1.3514 (0.4); 1.2279 (0.4) I.1-227:1H NMR (400.0MHz, d6-DMSO): δ= 7.1473 (2.0); 7.1271 (7.0); 7.1106 (7.6); 7.0901 (2.1); 4.7989 (0.7); 4.7851 (0.9); 4.7719 (0.7); 4.7664 (0.5); 4.6675 (1.9); 4.6293 (2.1); 4.0466 (1.9); 4.0084 (1.7); 3.7115 (0.6); 3.7012 (0.8); 3.6906 (1.0); 3.6801 (0.8); 3.6698 (0.6); 3.3933 (63.2); 2.7348 (0.8); 2.7251 (1.6); 2.7156 (0.8); 2.6957 (1.1); 2.6861 (1.9); 2.6766 (1.2); 2.5251 (0.8); 2.5204 (1.1); 2.5117 (18.1); 2.5072 (38.7); 2.5026 (53.0); 2.4980 (37.8); 2.4935 (17.4); 2.4002 (1.2); 2.3932 (1.8); 2.3782 (1.5); 2.3712 (1.9); 2.3614 (1.0); 2.3541 (1.4); 2.3393 (1.0); 2.3320 (1.0); 2.2918 (0.7); 2.2757 (16.0); 2.2531 (1.1); 2.2277 (0.5); 2.2134 (0.5); 2.1460 (0.6); 2.1216 (0.5); 2.1144 (0.8); 2.0898 (0.5); 1.6948 (0.5); 1.6787 (0.6); 1.6710 (0.5); 1.6631 (0.6); 1.4761 (0.5); 1.4681 (0.5); 1.4584 (0.8); 1.4519 (0.7); 1.4436 (1.2); 1.4374 (0.6); 1.4340 (0.6); 1.4257 (1.1); 1.4192 (1.0); 1.4141 (0.6); 1.4109 (0.7); 1.4056 (1.0); 1.3918 (0.7); 1.3899 (0.7); 1.2766 (0.7); 1.2560 (1.2); 1.2377 (1.4); 1.2315 (0.7); 1.2208 (1.0); 1.2135 (0.7); 1.2040 (0.5); 1.1968 (0.6); 1.1231 (7.7); 1.1206 (7.7); 1.1075 (7.7); 1.1049 (7.6); 0.8620 (4.9); 0.8433 (9.4); 0.8253 (4.1); -0.0002 (9.6) I.1-228:1H NMR (400.0 MHz, d6-DMSO): δ= 7.1395 (2.1); 7.1193 (7.0); 7.1024 (7.8); 7.0819 (2.2); 4.6163 (2.0); 4.5785 (2.3); 4.0917 (2.2); 4.0538 (2.0); 3.7972 (0.7); 3.7867 (0.9); 3.7765 (1.1); 3.7666 (0.9); 3.7561 (0.7); 3.4312 (20.4); 3.3139 (0.6); 3.2974 (1.1); 3.2890 (0.9); 3.2801 (0.8); 3.2724 (1.6); 3.2551 (0.9); 3.2260 (1.8); 3.2092 (3.4); 3.1923 (1.7); 3.1714 (0.8); 3.1687 (0.9); 3.1548 (1.4); 3.1467 (0.6); 3.1381 (0.9); 3.1296 (1.0); 3.1129 (0.6); 2.6413 (1.1); 2.6305 (1.1); 2.6012 (1.4); 2.5904 (1.3); 2.5234 (0.7); 2.5186 (0.9); 2.5099 (18.2); 2.5054 (40.5); 2.5008 (57.2); 2.4962 (40.4); 2.4916 (18.5); 2.4228 (0.6); 2.4181 (0.6); 2.3998 (1.2); 2.3810 (0.9); 2.3766 (0.8); 2.3582 (0.8); 2.3278 (1.7); 2.3061 (1.4); 2.2879 (1.3); 2.2729 (16.0); 2.2498 (1.0); 2.2390 (1.3); 2.2254 (1.3); 2.2084 (0.5); 2.1973 (0.8); 2.1842 (0.8); 2.1235 (0.8); 2.1110 (0.6); 2.1050 (0.5); 2.0993 (0.6); 2.0922 (0.9); 2.0869 (0.5); 2.0719 (0.8); 2.0676 (0.7); 1.8212 (0.8); 1.8102 (1.2); 1.8047 (1.4); 1.7943 (1.6); 1.7868 (1.2); 1.7785 (1.3); 1.7627 (0.7); 1.7448 (1.1); 1.7287 (2.7); 1.7123 (2.9); 1.6953 (1.5); 1.6830 (0.6); 1.6716 (0.7); 1.6600 (0.8); 1.6484 (0.7); 1.6398 (0.7); 1.6281 (0.7); 1.6162 (0.5) I.1-230:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.9121 (1.0); 7.3525 (1.0); 7.3309 (1.0); 7.3270 (0.9); 7.3107 (0.5); 7.3069 (0.5); 7.2071 (0.6); 7.2031 (0.6); 7.1945 (0.6); 7.1904 (0.7); 7.1872 (1.1); 7.1833 (1.2); 7.1744 (1.0); 7.1708 (1.2); 7.1668 (0.7); 7.1627 (0.7); 7.1540 (0.6); 7.1503 (0.6); 7.0730 (1.1); 7.0570 (1.5); 7.0376 (0.8); 4.7349 (1.7); 4.6950 (2.0); 4.2353 (2.1); 4.1954 (1.8); 3.8054 (0.7); 3.7953 (0.9); 3.7849 (1.3); 3.7747 (1.0); 3.7645 (0.7); 3.3070 (72.1); 3.2566 (0.6); 3.1685 (0.5); 2.9992 (1.0); 2.9817 (2.1); 2.9677 (2.2); 2.9560 (2.0); 2.9386 (1.0); 2.6695 (0.6); 2.5229 (1.7); 2.5182 (2.4); 2.5095 (38.6); 2.5050 (84.7); 2.5003 (118.4); 2.4957 (83.3); 2.4911 (36.6); 2.4723 (2.1); 2.4604 (2.2); 2.4552 (0.8); 2.4505 (0.9); 2.4459 (0.6); 2.3803 (0.6); 2.3578 (1.2); 2.3361 (1.3); 2.3271 (0.8); 2.3224 (0.6); 2.3161 (1.1); 2.2858 (1.0); 2.2723 (1.2); 2.2617 (1.5); 2.2483 (1.5); 2.2305 (0.5); 2.2198 (0.8); 2.2066 (0.8); 2.1970 (1.9); 2.1758 (1.8); 2.1622 (1.6); 2.1465 (0.7); 2.1409 (1.6); 2.1272 (1.0); 2.1227 (0.6); 2.1149 (0.7); 2.1079 (0.6); 2.1032 (0.8); 2.0956 (1.1); 2.0910 (0.7); 2.0763 (0.6); 2.0714 (1.3); 1.7588 (0.7); 1.7478 (0.9); 1.7378 (0.7); 1.7268 (0.7); 1.7160 (0.8); 1.3962 (2.0); 1.3781 (4.1); 1.3600 (4.5); 1.3420 (2.4); 1.3239 (0.5); 0.8362 (7.6); 0.8178 (16.0); 0.7991 (6.7); -0.0002 (9.2) I.1-231:1H NMR (400.1 MHz, d6-DMSO): δ= 7.1977 (1.4); 7.1491 (1.9); 7.1288 (7.5); 7.1153 (8.3); 7.0946 (2.1); 7.0660 (3.0); 6.9343 (1.6); 4.6390 (2.1); 4.6008 (2.3); 4.0280 (2.4); 3.9898 (2.2); 3.7637 (0.4); 3.7536 (0.8); 3.7429 (1.0); 3.7320 (1.2); 3.7218 (1.1); 3.7115 (0.8); 3.7012 (0.4); 2.8114 (1.3); 2.8013 (1.4); 2.7721 (1.6); 2.7620 (1.6); 2.5181 (0.4); 2.5094 (9.3); 2.5049 (21.4); 2.5002 (30.9); 2.4956 (23.0); 2.4911 (11.3); 2.4443 (1.5); 2.4312 (0.6); 2.4219 (1.6); 2.4053 (1.7); 2.3885 (1.3); 2.3828 (1.5); 2.3697 (1.0); 2.3662 (1.0); 2.3466 (0.8); 2.2778 (16.0); 2.2615 (1.4); 2.2484 (1.2); 2.2444 (0.7); 2.2311 (0.5); 2.2195 (0.7); 2.2068 (0.7); 2.1524 (0.4); 2.1330 (0.8); 2.1285 (0.5); 2.1204 (0.6); 2.1138 (0.6); 2.1087 (0.7); 2.1013 (0.9); 2.0966 (0.6); 2.0897 (0.4); 2.0817 (0.5); 2.0769 (0.7); 1.7193 (0.4); 1.7072 (0.6); 1.6960 (0.8); 1.6855 (0.8); 1.6748 (0.8); 1.6641 (0.8); 1.6527 (0.5); 1.6404 (0.3) I.1-233:1H NMR (400.1 MHz, d6-DMSO): δ= 11.5146 (0.9); 7.3755 (0.8); 7.3571 (1.0); 7.3503 (0.4); 7.3458 (0.8); 7.3416 (0.6); 7.2944 (0.9); 7.2018 (0.6); 7.1838 (0.5); 4.6606 (0.6); 4.6216 (0.6); 4.1332 (0.6); 4.0941 (0.6); 3.3344 (37.3); 2.7738 (16.0); 2.7385 (0.4); 2.7282 (0.4); 2.7009 (0.5); 2.6906 (0.4); 2.5113 (4.0); 2.5068 (8.8); 2.5023 (12.3); 2.4977 (8.9); 2.4932 (4.2); 2.3972 (0.3); 2.3782 (0.3); 2.3718 (0.6); 2.3492 (0.5); 2.3339 (0.4); 2.3111 (0.5); 2.2985 (0.4); 2.2851 (0.3) I.1-235:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.7425 (0.7); 7.7236 (0.7); 7.1456 (1.4); 7.1251 (6.3); 7.1136 (7.1); 7.1077 (1.1); 7.0928 (1.5); 4.6667 (0.9); 4.6611 (0.9); 4.6289 (1.0); 4.6232 (1.0); 4.0300 (1.0); 4.0218 (1.0); 3.9919 (0.9); 3.9835 (0.9); 3.7081 (0.6); 3.6967 (0.7); 3.6855 (0.6); 3.6743 (0.6); 3.6475 (0.5); 3.6401 (0.5); 3.6309 (0.6); 3.6274 (0.6); 3.4529 (16.0); 2.5233 (0.6); 2.5186 (0.8); 2.5100 (13.0); 2.5054 (28.1); 2.5008 (39.0); 2.4962 (27.1); 2.4916 (12.3); 2.4821 (1.4); 2.4707 (0.7); 2.4593 (0.8); 2.4480 (1.4); 2.4367 (0.7); 2.3447 (0.9); 2.3264 (0.9); 2.3228 (0.9); 2.3026 (0.7); 2.2760 (13.0); 2.2588 (0.6); 2.2531 (0.6); 2.2488 (0.6); 2.2428 (0.6); 2.2347 (0.6); 2.2293 (0.6); 2.1058 (1.2); 2.0832 (1.2); 2.0716 (1.1); 2.0491 (1.1); 2.0120 (0.6); 1.3693 (1.4); 1.3583 (0.8); 1.3510 (2.1); 1.3401 (1.1); 1.3334 (1.6); 1.3219 (0.7); 0.9965 (5.6); 0.9935 (5.7); 0.9799 (5.6); 0.9770 (5.6); 0.8170 (2.6); 0.8128 (2.6); 0.7986 (5.4); 0.7944 (5.4); 0.7799 (2.3); 0.7758 (2.2) I.1-237:1H NMR (400.0MHz, CDCl3): δ= 7.2613 (34.4); 7.2290 (0.9); 7.2241 (0.6); 7.2157 (0.6); 7.2136 (0.6); 7.2087 (1.0); 7.2038 (0.6); 7.1954 (0.5); 7.1906 (0.6); 7.1692 (0.5); 7.1648 (0.6); 7.1505 (1.3); 7.1460 (1.3); 7.1316 (1.1); 7.1271 (0.9); 7.1122 (27.7); 7.0931 (1.8); 7.0900 (1.9); 7.0745 (1.8); 7.0715 (2.0); 7.0559 (0.7); 7.0529 (0.8); 7.0469 (1.0); 7.0442 (0.9); 7.0264 (0.8); 7.0220 (1.2); 7.0188 (1.0); 7.0010 (0.8); 6.9979 (0.8); 5.3879 (0.6); 5.2980 (0.5); 4.7028 (1.8); 4.6652 (2.0); 4.1193 (1.8); 4.0817 (1.6); 3.9358 (0.6); 3.9252 (0.8); 3.9150 (1.0); 3.9050 (0.8); 3.8944 (0.7); 3.5006 (0.8); 3.4833 (1.2); 3.4676 (1.1); 3.4609 (0.5); 3.4505 (0.6); 3.4438 (1.0); 3.4287 (1.1); 3.4116 (0.7); 2.8288 (1.5); 2.8117 (3.0); 2.7946 (1.4); 2.4989 (1.3); 2.4876 (1.5); 2.4693 (1.0); 2.4629 (1.5); 2.4514 (2.2); 2.4276 (0.8); 2.4127 (0.9); 2.3984 (1.0); 2.3884 (1.2); 2.3743 (1.2); 2.3700 (0.5); 2.3456 (0.6); 2.3315 (0.7); 2.3216 (16.0); 2.1912 (0.7); 2.1779 (0.5); 2.1670 (0.7); 2.1587 (0.8); 2.1538 (0.5); 2.1342 (0.7); 2.0678 (1.5); 2.0462 (1.5); 2.0317 (1.3); 2.0101 (1.3); 1.7343 (0.6); 1.7243 (0.6); 1.7115 (0.6); 1.7010 (0.5); -0.0002 (10.3) I.1-238:1H NMR (400.0 MHz, CDCl3): δ= 7.5217 (1.2); 7.2627 (223.6); 7.2269 (2.2); 7.2106 (4.4); 7.2059 (3.8); 7.1942 (2.5); 7.1896 (8.4); 7.1850 (3.1); 7.1733 (3.8); 7.1687 (5.2); 7.1524 (2.5); 7.1168 (1.4); 7.1063 (2.2); 7.1022 (1.8); 7.0921 (5.0); 7.0800 (3.3); 7.0762 (3.6); 7.0735 (4.0); 7.0675 (7.0); 7.0601 (2.2); 7.0558 (3.2); 7.0486 (14.2); 7.0419 (12.2); 7.0380 (9.2); 7.0334 (16.0); 7.0250 (6.8); 7.0226 (5.7); 7.0129 (1.2); 7.0059 (1.1); 6.9987 (1.2); 6.9030 (1.2); 6.8986 (1.6); 6.8870 (10.5); 6.8780 (1.9); 6.8674 (14.1); 6.8566 (2.0); 6.8472 (9.2); 6.8352 (1.3); 6.8316 (1.0); 5.5095 (2.9); 5.2996 (0.8); 4.8468 (6.2); 4.8432 (6.2); 4.8080 (7.0); 4.8044 (7.0); 4.2270 (9.2); 4.1882 (8.1); 3.9262 (1.5); 3.9153 (3.1); 3.9041 (3.6); 3.8956 (3.8); 3.8926 (3.8); 3.8840 (3.6); 3.8727 (3.2); 3.8619 (1.5); 3.5525 (0.6); 3.5360 (1.6); 3.5189 (3.4); 3.5022 (7.1); 3.4859 (8.0); 3.4828 (8.0); 3.4669 (7.5); 3.4505 (3.3); 3.4330 (1.7); 3.4173 (0.6); 2.9016 (7.7); 2.8853 (14.6); 2.8689 (6.8); 2.5965 (6.4); 2.5860 (6.4); 2.5603 (7.4); 2.5498 (7.3); 2.5154 (1.3); 2.4954 (1.8); 2.4919 (1.7); 2.4716 (4.7); 2.4523 (4.2); 2.4490 (4.0); 2.4301 (3.9); 2.4118 (4.6); 2.3972 (5.4); 2.3876 (6.3); 2.3732 (6.4); 2.3689 (2.5); 2.3543 (2.0); 2.3446 (2.9); 2.3303 (2.9); 2.2516 (2.4); 2.2325 (3.8); 2.2276 (2.3); 2.2187 (2.9); 2.2135 (2.4); 2.2083 (3.2); 2.1998 (4.3); 2.1946 (2.8); 2.1895 (1.9); 2.1806 (2.6); 2.1754 (3.5); 2.1564 (1.8); 2.1158 (8.4); 2.0927 (8.3); 2.0797 (7.5); 2.0566 (7.4); 1.9860 (0.6); 1.8107 (2.2); 1.7994 (2.4); 1.7966 (2.8); 1.7858 (3.2); 1.7761 (3.1); 1.7728 (2.6); 1.7666 (2.5); 1.7632 (3.1); 1.7524 (2.8); 1.7429 (2.1); 1.7399 (1.9); 1.7284 (1.8); 0.0079 (1.8); -0.0002 (67.7); -0.0085 (2.2) I.1-240:1H NMR (400.0 MHz, CDCl3): δ= 7.2606 (70.3); 7.2152 (1.3); 7.1965 (3.2); 7.1777 (2.0); 7.1054 (0.6); 7.0917 (1.2); 7.0797 (0.7); 7.0733 (1.0); 7.0648 (1.9); 7.0596 (2.2); 7.0490 (1.5); 7.0456 (3.6); 7.0392 (3.8); 7.0357 (2.7); 7.0311 (4.0); 7.0222 (1.6); 6.9966 (0.6); 6.9864 (2.8); 6.9702 (1.7); 6.9512 (1.4); 5.3741 (0.8); 4.8420 (1.5); 4.8385 (1.6); 4.8033 (1.7); 4.7997 (1.7); 4.2253 (2.2); 4.1866 (2.0); 3.9306 (0.8); 3.9197 (0.9); 3.9091 (1.0); 3.8997 (0.9); 3.8887 (0.8); 3.5295 (0.9); 3.5123 (2.1); 3.4970 (3.3); 3.4817 (2.0); 3.4650 (1.0); 2.7739 (2.6); 2.7567 (5.3); 2.7395 (2.4); 2.5772 (1.6); 2.5663 (1.5); 2.5412 (1.8); 2.5303 (1.8); 2.4668 (1.2); 2.4475 (1.0); 2.4439 (1.0); 2.4244 (1.0); 2.4139 (1.2); 2.3992 (1.3); 2.3899 (1.6); 2.3754 (1.6); 2.3712 (0.6); 2.3469 (0.7); 2.3276 (16.0); 2.2669 (0.6); 2.2478 (1.0); 2.2431 (0.6); 2.2343 (0.7); 2.2288 (0.6); 2.2238 (0.8); 2.2152 (1.0); 2.2103 (0.6); 2.1961 (0.6); 2.1910 (0.8); 2.1057 (2.0); 2.0833 (1.9); 2.0697 (1.7); 2.0473 (1.7); 1.8160 (0.5); 1.8046 (0.6); 1.8019 (0.7); 1.7908 (0.8); 1.7813 (0.7); 1.7780 (0.6); 1.7719 (0.6); 1.7687 (0.7); 1.7576 (0.6); 1.7484 (0.5); 1.6474 (0.8); 0.0080 (0.6); -0.0002 (18.1) I.1-241:1H NMR (400.0MHz, d6-DMSO): δ= 12.4940 (0.7); 8.2483 (1.5); 8.2290 (1.4); 7.1444 (1.4); 7.1238 (8.8); 7.1155 (9.5); 7.0943 (1.6); 4.6609 (1.9); 4.6224 (2.1); 4.1992 (0.6); 4.1848 (0.9); 4.1788 (0.8); 4.1652 (0.9); 4.1417 (0.6); 4.0209 (2.0); 3.9830 (1.7); 3.9090 (0.9); 3.6991 (0.7); 3.6883 (0.8); 3.6756 (0.9); 3.6657 (0.8); 3.6555 (0.6); 3.3532 (0.5); 3.3164 (53.5); 3.1634 (1.0); 2.6744 (1.3); 2.6698 (1.9); 2.6650 (1.4); 2.5717 (1.4); 2.5634 (1.4); 2.5445 (1.7); 2.5398 (3.0); 2.5302 (0.8); 2.5232 (3.4); 2.5185 (5.8); 2.5098 (100.7); 2.5053 (223.1); 2.5006 (314.6); 2.4960 (219.7); 2.4914 (98.4); 2.4731 (2.3); 2.4685 (1.6); 2.3743 (0.6); 2.3542 (1.0); 2.3321 (2.2); 2.3275 (2.1); 2.3229 (1.5); 2.3114 (0.9); 2.2760 (16.0); 2.2567 (1.1); 2.2461 (1.2); 2.2328 (1.1); 2.2151 (0.6); 2.2040 (0.6); 2.1911 (0.6); 2.1751 (1.4); 2.1517 (1.4); 2.1409 (1.2); 2.1175 (1.3); 2.0732 (0.9); 2.0226 (0.7); 1.9989 (0.7); 1.9910 (0.9); 1.9662 (0.7); 1.7716 (0.5); 1.7611 (0.9); 1.7515 (0.7); 1.7388 (0.7); 1.7288 (0.6); 1.5957 (0.7); 1.5803 (0.6); 1.5107 (1.3); 1.4987 (2.0); 1.4846 (1.9); 1.4751 (1.4); 1.4624 (1.1); 0.8937 (9.3); 0.8773 (8.9); 0.8285 (9.1); 0.8123 (9.0); 0.0081 (3.5); -0.0002 (129.9); -0.0085 (3.5); -0.0330 (0.6) I.1-242:1H NMR (400.1 MHz, i.e6-DMSO): δ= 11.4782 (1.1); 7.3908 (0.5); 7.3752 (0.5); 7.3557 (0.4); 7.0906 (0.5); 7.0813 (0.8); 7.0606 (1.0); 7.0303 (0.5); 4.6714 (0.7); 4.6321 (0.8); 4.1460 (0.8); 4.1067 (0.7); 3.7890 (0.3); 3.7780 (0.4); 3.7682 (0.3); 3.3164 (8.6); 2.7726 (16.0); 2.7288 (0.5); 2.7184 (0.5); 2.6912 (0.5); 2.6808 (0.5); 2.5089 (5.5); 2.5046 (11.8); 2.5001 (16.5); 2.4957 (12.6); 2.3955 (0.4); 2.3744 (0.9); 2.3524 (0.8); 2.3368 (0.5); 2.3222 (0.4); 2.3146 (0.5); 2.3089 (0.4); 2.2979 (0.4); 2.2843 (0.4); 2.0709 (0.8); 0.0000 (2.7) I.1-243:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.9112 (1.8); 8.8898 (1.9); 7.3503 (1.2); 7.3480 (2.0); 7.3436 (1.9); 7.3412 (2.2); 7.3375 (1.4); 7.3298 (3.8); 7.3273 (5.4); 7.3230 (3.7); 7.3206 (4.5); 7.3112 (5.2); 7.3045 (4.5); 7.2638 (9.0); 7.2540 (8.7); 7.2458 (6.3); 7.2360 (5.9); 7.2274 (1.4); 7.2238 (0.6); 7.2206 (0.6); 7.2170 (0.9); 7.1155 (2.5); 7.0956 (6.7); 7.0737 (7.6); 7.0532 (2.7); 6.1145 (2.3); 6.0931 (2.3); 4.6523 (1.9); 4.6143 (2.1); 3.9910 (2.2); 3.9531 (2.0); 3.7351 (0.7); 3.7243 (0.9); 3.7140 (1.1); 3.7041 (0.9); 3.6934 (0.7); 3.3257 (17.3); 2.6441 (1.3); 2.6330 (1.3); 2.6095 (1.6); 2.5983 (1.5); 2.5088 (6.6); 2.5042 (14.3); 2.4996 (20.0); 2.4950 (14.0); 2.4904 (6.2); 2.3525 (0.5); 2.3332 (1.2); 2.3216 (1.8); 2.3146 (1.1); 2.3105 (1.1); 2.2994 (1.7); 2.2870 (1.6); 2.2620 (16.0); 2.2437 (1.2); 2.2333 (1.2); 2.2196 (1.2); 2.2159 (0.7); 2.2019 (0.6); 2.1915 (0.6); 2.1779 (0.6); 2.0712 (8.4); 2.0254 (0.7); 2.0209 (0.5); 2.0129 (0.6); 2.0062 (0.5); 2.0012 (0.7); 1.9938 (0.9); 1.9890 (0.6); 1.9743 (0.5); 1.9696 (0.7); 1.7253 (0.6); 1.7146 (0.8); 1.7042 (0.7); 1.6930 (0.7); 1.6826 (0.7); -0.0002 (2.4) I.1-244:1H NMR (400.0MHz, d6-DMSO): δ= 7.4244 (0.9); 7.4068 (2.3); 7.3879 (2.0); 7.3624 (0.8); 7.3457 (0.7); 7.1934 (3.6); 7.1896 (5.3); 7.1844 (1.2); 7.1722 (3.6); 7.0930 (2.1); 7.0743 (2.6); 6.9680 (1.6); 6.9504 (1.3); 4.4167 (0.6); 4.3796 (0.6); 3.9338 (0.7); 3.8984 (0.6); 3.7518 (0.8); 3.7417 (0.7); 3.3198 (103.0); 3.1682 (0.5); 3.1079 (4.8); 2.6697 (0.6); 2.5231 (1.2); 2.5184 (1.8); 2.5098 (33.4); 2.5052 (72.9); 2.5006 (102.3); 2.4960 (71.7); 2.4914 (32.4); 2.4499 (0.6); 2.4391 (0.6); 2.4036 (0.6); 2.3273 (0.6); 2.2819 (16.0); 2.1961 (1.2); 2.1814 (0.9); 2.1029 (0.6); 2.0827 (0.6); 2.0719 (0.9); 2.0505 (0.5); -0.0002 (0.6) I.1-246:1H NMR (400.1 MHz, CDCl3): δ= 7.5201 (0.5); 7.5182 (0.5); 7.2613 (82.2); 7.2593 (80.8); 7.1275 (0.4); 7.1150 (0.9); 7.1029 (1.6); 7.0924 (1.1); 7.0849 (1.7); 7.0782 (1.7); 7.0692 (1.0); 7.0590 (6.4); 7.0487 (6.1); 7.0412 (2.1); 7.0363 (2.0); 6.9974 (0.5); 6.9955 (0.4); 4.8980 (2.5); 4.8595 (2.8); 4.7241 (1.1); 4.7131 (1.2); 4.6968 (2.2); 4.6859 (2.3); 4.6695 (1.2); 4.6584 (1.1); 4.2514 (3.7); 4.2126 (3.3); 3.9077 (0.5); 3.8965 (1.0); 3.8858 (1.5); 3.8754 (1.6); 3.8648 (1.5); 3.8541 (1.1); 3.8429 (0.6); 2.7495 (2.2); 2.7398 (2.2); 2.7112 (2.7); 2.7015 (2.7); 2.5585 (0.6); 2.5411 (0.8); 2.5341 (0.7); 2.5159 (1.9); 2.4981 (1.6); 2.4915 (1.5); 2.4741 (1.6); 2.4425 (1.3); 2.4272 (1.5); 2.4181 (1.9); 2.4021 (2.0); 2.3846 (3.2); 2.3752 (1.1); 2.3608 (3.5); 2.3463 (2.3); 2.3235 (2.2); 2.3064 (0.8); 2.2875 (1.2); 2.2730 (0.9); 2.2631 (0.9); 2.2549 (1.4); 2.2497 (0.9); 2.2355 (0.8); 2.2304 (1.0); 2.2121 (0.5); 1.9448 (1.3); 1.9154 (1.4); 1.8476 (0.7); 1.8342 (1.1); 1.8219 (1.5); 1.8098 (2.0); 1.8019 (2.0); 1.7911 (2.1); 1.7865 (1.9); 1.7754 (1.6); 1.7675 (1.2); 1.7571 (0.5); 1.7505 (0.5); 1.6912 (2.6); 1.6831 (2.1); 1.6643 (2.6); 1.6578 (2.6); 1.6497 (1.8); 1.6427 (0.7); 1.5553 (22.8); 1.5209 (0.3); 1.5111 (0.5); 1.5035 (0.5); 1.4900 (0.8); 1.4812 (0.9); 1.4736 (0.9); 1.4656 (1.0); 1.4578 (0.8); 1.4521 (0.7); 1.4440 (0.6); 1.4360 (0.5); 1.4274 (0.3); 1.3865 (0.6); 1.3789 (0.9); 1.3719 (0.6); 1.3496 (1.6); 1.3283 (0.7); 1.3210 (1.1); 1.3135 (0.6); 1.0953 (0.4); 1.0847 (0.6); 1.0590 (1.2); 1.0531 (1.3); 1.0281 (1.6); 1.0203 (1.3); 0.9964 (0.6); 0.9885 (0.6); 0.9779 (1.2); 0.9484 (2.9); 0.9192 (3.1); 0.9095 (15.0); 0.9013 (16.0); 0.8933 (15.0); 0.8839 (14.6); 0.8685 (1.8); 0.8448 (1.2); 0.8137 (0.5); 0.7498 (14.3); 0.7324 (14.0); 0.0061 (1.3) I.1-247:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5979 (0.5); 8.5851 (0.7); 8.5706 (8.8); 8.5685 (10.2); 8.5664 (10.6); 8.5642 (9.4); 8.5582 (9.3); 8.5560 (10.7); 8.5540 (10.4); 8.5517 (9.2); 7.8983 (6.0); 7.8939 (6.1); 7.8790 (11.7); 7.8746 (11.8); 7.8597 (6.9); 7.8553 (6.8); 7.4494 (0.6); 7.4385 (0.5); 7.3955 (7.4); 7.3829 (7.9); 7.3792 (7.0); 7.3767 (7.0); 7.3632 (13.9); 7.3610 (14.2); 7.3411 (12.3); 7.3229 (0.5); 4.7555 (13.4); 4.7150 (16.0); 4.4884 (0.6); 4.4732 (0.6); 4.4305 (1.2); 4.4222 (1.6); 4.4075 (1.1); 4.3904 (1.2); 4.3759 (1.2); 4.3253 (15.0); 4.2848 (13.0); 4.2337 (1.3); 4.1082 (1.6); 3.9353 (1.1); 3.9247 (1.1); 3.9144 (1.0); 3.8991 (2.8); 3.8885 (4.2); 3.8770 (5.9); 3.8692 (5.7); 3.8665 (5.8); 3.8579 (5.8); 3.8471 (4.6); 3.8360 (2.3); 3.1686 (0.7); 2.9967 (0.5); 2.7230 (9.6); 2.7129 (9.9); 2.6832 (12.2); 2.6731 (12.2); 2.5249 (1.3); 2.5201 (2.1); 2.5115 (41.0); 2.5069 (90.2); 2.5023 (127.1); 2.4977 (90.3); 2.4931 (41.2); 2.4617 (0.7); 2.4570 (1.1); 2.4518 (3.2); 2.4434 (1.1); 2.4352 (3.4); 2.4210 (1.5); 2.4104 (7.8); 2.3918 (16.2); 2.3870 (7.2); 2.3744 (3.4); 2.3693 (12.7); 2.3599 (2.8); 2.3521 (11.3); 2.3295 (11.0); 2.3199 (0.9); 2.3110 (4.8); 2.2974 (4.6); 2.2867 (9.4); 2.2734 (9.2); 2.2471 (12.7); 2.2396 (6.9); 2.2379 (6.8); 2.2331 (5.6); 2.2290 (4.2); 2.2234 (2.1); 2.2170 (4.9); 2.2149 (4.6); 2.2088 (2.4); 2.2046 (2.0); 2.1978 (3.6); 2.1927 (2.5); 2.1905 (2.7); 2.1734 (1.9); 1.7883 (1.5); 1.7830 (0.9); 1.7647 (3.3); 1.7614 (3.9); 1.7534 (5.7); 1.7475 (3.5); 1.7422 (4.2); 1.7358 (3.0); 1.7284 (4.2); 1.7237 (4.0); 1.7112 (3.7); 1.6980 (2.2); 0.0080 (0.5); -0.0002 (18.6); -0.0086 (0.6) I.1-248:1H NMR (400.0MHz, CDCl3): δ= 7.5212 (1.0); 7.3558 (5.6); 7.3360 (11.8); 7.3162 (7.9); 7.2729 (0.6); 7.2721 (0.7); 7.2713 (0.7); 7.2705 (0.8); 7.2697 (0.9); 7.2680 (1.4); 7.2622 (188.6); 7.1213 (6.8); 7.1103 (5.7); 7.1037 (9.1); 7.0965 (5.2); 7.0869 (5.2); 7.0840 (5.7); 7.0807 (4.5); 7.0779 (3.6); 7.0703 (4.9); 7.0640 (1.6); 7.0588 (2.0); 7.0535 (4.5); 7.0509 (9.6); 7.0440 (9.0); 7.0406 (7.1); 7.0359 (12.4); 7.0273 (6.4); 7.0248 (7.3); 7.0171 (7.6); 6.9982 (1.1); 5.4464 (2.4); 4.8443 (4.8); 4.8407 (4.8); 4.8056 (5.4); 4.8019 (5.4); 4.2387 (6.9); 4.1999 (6.2); 3.9469 (1.1); 3.9358 (2.3); 3.9250 (2.9); 3.9148 (3.2); 3.9049 (2.9); 3.8939 (2.4); 3.8829 (1.2); 3.5743 (0.6); 3.5566 (1.4); 3.5403 (3.0); 3.5226 (5.6); 3.5175 (2.6); 3.5074 (5.4); 3.5049 (4.1); 3.5002 (5.3); 3.4898 (2.9); 3.4851 (5.5); 3.4680 (3.0); 3.4510 (1.3); 3.4338 (0.6); 2.8432 (8.2); 2.8258 (16.0); 2.8083 (7.3); 2.5915 (4.9); 2.5806 (4.9); 2.5553 (5.7); 2.5444 (5.6); 2.5163 (1.0); 2.4963 (1.3); 2.4931 (1.2); 2.4734 (3.5); 2.4534 (3.2); 2.4500 (3.1); 2.4304 (3.1); 2.4201 (3.6); 2.4053 (4.2); 2.3960 (5.0); 2.3814 (5.0); 2.3773 (1.8); 2.3625 (1.4); 2.3530 (2.2); 2.3386 (2.1); 2.2718 (1.9); 2.2527 (2.9); 2.2480 (1.8); 2.2392 (2.3); 2.2338 (1.8); 2.2287 (2.4); 2.2203 (3.2); 2.2152 (2.1); 2.2098 (1.4); 2.2011 (2.0); 2.1959 (2.5); 2.1769 (1.3); 2.1280 (6.3); 2.1056 (6.2); 2.0918 (5.6); 2.0695 (5.6); 2.0061 (0.6); 1.8106 (1.6); 1.7992 (1.8); 1.7964 (2.1); 1.7852 (2.2); 1.7758 (2.2); 1.7727 (1.9); 1.7665 (1.9); 1.7633 (2.3); 1.7543 (1.7); 1.7520 (2.0); 1.7430 (1.6); 1.7399 (1.5); 1.7283 (1.3); 0.0080 (1.6); 0.0048 (0.6); -0.0002 (55.5); -0.0085 (1.6) I.1-250:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.9170 (2.3); 7.9128 (14.2); 7.9084 (4.8); 7.8964 (5.1); 7.8919 (16.0); 7.8877 (2.7); 7.8806 (0.7); 7.3502 (12.4); 7.3293 (11.6); 4.7296 (4.9); 4.6899 (5.6); 4.2365 (5.5); 4.1969 (4.8); 3.7626 (1.0); 3.7519 (1.7); 3.7410 (2.4); 3.7321 (2.4); 3.7207 (2.4); 3.7101 (1.9); 3.6995 (1.0); 2.6818 (3.6); 2.6718 (4.1); 2.6420 (4.6); 2.6321 (4.2); 2.5252 (0.7); 2.5204 (1.1); 2.5118 (17.4); 2.5072 (37.1); 2.5026 (51.4); 2.4979 (36.8); 2.4934 (17.1); 2.4640 (1.2); 2.4461 (1.1); 2.4394 (1.2); 2.4224 (2.8); 2.4047 (2.2); 2.3988 (2.0); 2.3817 (1.8); 2.3410 (4.7); 2.3293 (0.7); 2.3185 (5.4); 2.3068 (2.4); 2.3012 (4.4); 2.2965 (3.3); 2.2822 (3.5); 2.2787 (5.2); 2.2659 (0.8); 2.2547 (1.8); 2.2418 (2.0); 2.2269 (1.3); 2.2086 (1.7); 2.2028 (0.9); 2.1963 (1.5); 2.1909 (1.3); 2.1840 (1.3); 2.1784 (2.0); 2.1722 (1.3); 2.1666 (0.9); 2.1591 (1.3); 2.1536 (1.3); 2.1348 (0.7); 1.7550 (0.9); 1.7431 (1.5); 1.7317 (1.9); 1.7240 (1.4); 1.7208 (1.6); 1.7124 (1.8); 1.7072 (1.3); 1.7001 (1.8); 1.6888 (1.2); 1.6754 (0.8); 0.0081 (0.6); -0.0002 (19.7); -0.0085 (0.6) I.1-251:1H NMR (400.0MHz, CDCl3): δ= 7.3710 (3.4); 7.3505 (3.7); 7.2618 (34.8); 7.2403 (2.7); 7.2351 (2.8); 7.1164 (29.3); 7.0003 (1.6); 6.9951 (1.6); 6.9798 (1.4); 6.9746 (1.4); 5.3852 (0.6); 5.2987 (1.1); 4.6996 (1.8); 4.6620 (2.0); 4.1348 (1.8); 4.0973 (1.6); 3.9439 (0.6); 3.9336 (0.7); 3.9233 (1.1); 3.9130 (0.7); 3.9028 (0.6); 3.4661 (0.8); 3.4481 (1.2); 3.4326 (1.2); 3.4301 (1.0); 3.4147 (1.1); 3.4120 (1.1); 3.3970 (1.2); 3.3796 (0.7); 2.7421 (2.0); 2.7246 (4.0); 2.7070 (1.8); 2.4998 (1.2); 2.4884 (1.3); 2.4713 (0.9); 2.4637 (1.5); 2.4521 (2.2); 2.4288 (0.8); 2.4238 (0.9); 2.4093 (1.0); 2.3996 (1.1); 2.3854 (1.1); 2.3426 (0.5); 2.3240 (16.0); 2.2123 (0.7); 2.1991 (0.5); 2.1882 (0.6); 2.1798 (0.8); 2.1555 (0.6); 2.0796 (1.5); 2.0583 (1.4); 2.0435 (1.3); 2.0222 (1.2); 1.7360 (0.6); 1.7264 (0.6); 1.7132 (0.6); -0.0002 (9.8) I.1-252:1H NMR (400.1 MHz, CDCl3): δ= 7.5196 (1.8); 7.3109 (0.6); 7.3086 (0.5); 7.2977 (0.3); 7.2609 (311.4); 7.1347 (4.1); 7.1305 (1.7); 7.1139 (12.8); 7.1002 (4.9); 7.0936 (11.6); 7.0888 (11.5); 7.0682 (9.4); 7.0044 (4.8); 6.9971 (6.7); 6.9888 (4.4); 6.9829 (3.6); 6.9780 (3.6); 6.9726 (3.2); 5.6899 (0.8); 5.5264 (0.3); 5.4750 (3.9); 5.2984 (0.9); 4.6505 (9.3); 4.6123 (11.0); 4.2807 (1.6); 4.2426 (1.4); 4.1944 (10.8); 4.1564 (9.2); 4.1306 (0.4); 4.1182 (0.6); 4.1105 (0.7); 4.0992 (1.0); 4.0912 (0.5); 4.0872 (0.6); 4.0789 (0.7); 4.0664 (2.1); 4.0543 (2.9); 4.0470 (4.1); 4.0416 (2.8); 4.0352 (5.5); 4.0274 (2.8); 4.0222 (4.3); 4.0158 (3.1); 4.0028 (2.0); 3.2425 (0.5); 2.7307 (0.9); 2.7182 (1.0); 2.7021 (1.1); 2.6921 (3.2); 2.6843 (4.9); 2.6754 (6.7); 2.6666 (6.3); 2.6573 (4.7); 2.6488 (2.7); 2.6396 (1.1); 2.5670 (0.4); 2.5610 (0.4); 2.5479 (1.8); 2.5357 (0.4); 2.5243 (2.8); 2.5049 (6.2); 2.4836 (7.2); 2.4624 (6.6); 2.4490 (5.2); 2.4432 (2.6); 2.4346 (12.4); 2.4248 (7.9); 2.4209 (8.7); 2.4110 (7.3); 2.4061 (3.2); 2.3975 (9.7); 2.3923 (3.3); 2.3837 (11.2); 2.3682 (3.5); 2.3515 (0.6); 2.3402 (0.6); 2.3321 (0.7); 2.3210 (0.4); 2.3103 (3.0); 2.2910 (4.7); 2.2868 (2.4); 2.2779 (3.1); 2.2715 (2.6); 2.2671 (3.6); 2.2585 (5.1); 2.2539 (2.9); 2.2477 (1.9); 2.2388 (2.8); 2.2345 (3.9); 2.2150 (1.8); 2.1191 (8.9); 2.0999 (8.8); 2.0823 (7.3); 2.0631 (7.1); 2.0333 (0.4); 2.0046 (0.5); 1.9698 (0.7); 1.8775 (3.4); 1.8753 (3.4); 1.8124 (1.5); 1.7996 (1.6); 1.7929 (3.2); 1.7811 (4.0); 1.7690 (4.9); 1.7596 (4.4); 1.7460 (4.4); 1.7366 (3.7); 1.7257 (2.7); 1.7119 (2.0); 1.6951 (0.4); 0.8312 (0.3); 0.8257 (0.4); 0.8142 (0.6); 0.8049 (4.7); 0.7875 (16.0); 0.7738 (14.1); 0.7698 (12.7); 0.7664 (7.1); 0.7569 (5.4); 0.7361 (0.8); 0.7286 (0.5); 0.7162 (0.6); 0.5645 (0.4); 0.5540 (0.5); 0.5379 (0.6); 0.5274 (1.0); 0.5150 (1.2); 0.5045 (0.7); 0.4729 (5.4); 0.4629 (11.4); 0.4596 (12.5); 0.4564 (12.9); 0.4538 (12.2); 0.4500 (12.7); 0.4470 (12.0); 0.4332 (4.6); 0.4162 (0.4); 0.1464 (0.5); 0.0081 (3.5); 0.0000 (117.6) I.1-254:1H NMR (400.1 MHz, d6-DMSO): δ= 8.3599 (0.7); 8.3510 (1.1); 8.3400 (0.8); 8.3308 (1.0); 7.3878 (0.5); 7.3840 (0.5); 7.3672 (1.0); 7.3634 (1.1); 7.3575 (0.6); 7.3475 (0.7); 7.3415 (1.1); 7.3376 (1.0); 7.3211 (0.6); 7.3175 (0.6); 7.2526 (1.0); 7.2343 (2.3); 7.2285 (1.4); 7.2226 (1.4); 7.2170 (1.2); 7.2117 (1.6); 7.2056 (2.4); 7.2000 (1.8); 7.1931 (2.8); 7.1880 (2.4); 7.1833 (1.8); 7.1749 (2.7); 7.1713 (2.5); 7.1583 (1.7); 7.1537 (2.6); 7.1360 (1.3); 7.1226 (0.5); 7.1182 (0.4); 7.0947 (1.1); 7.0786 (1.5); 7.0595 (0.8); 5.2670 (0.8); 5.2492 (1.4); 5.2304 (1.2); 5.2116 (0.4); 4.7613 (1.8); 4.7216 (2.0); 4.2776 (1.4); 4.2673 (0.9); 4.2377 (1.2); 4.2275 (0.8); 3.8763 (0.5); 3.8657 (0.8); 3.8552 (1.1); 3.8451 (1.2); 3.8351 (0.9); 3.8246 (0.6); 3.4148 (16.0); 3.1685 (0.7); 2.9503 (0.3); 2.9406 (0.4); 2.9292 (0.4); 2.9193 (0.5); 2.9115 (0.7); 2.9017 (0.8); 2.8896 (0.7); 2.8799 (0.7); 2.8251 (0.6); 2.8045 (1.3); 2.7841 (1.0); 2.7746 (0.8); 2.7649 (0.7); 2.7449 (0.4); 2.6693 (0.4); 2.5985 (0.9); 2.5873 (1.0); 2.5823 (0.7); 2.5708 (0.7); 2.5639 (1.2); 2.5526 (1.3); 2.5480 (1.0); 2.5397 (0.7); 2.5363 (0.8); 2.5228 (0.8); 2.5180 (1.3); 2.5094 (22.6); 2.5049 (50.1); 2.5003 (70.6); 2.4957 (51.3); 2.4911 (24.5); 2.4246 (0.4); 2.4011 (0.9); 2.3913 (0.6); 2.3818 (1.8); 2.3702 (1.2); 2.3603 (1.8); 2.3502 (1.2); 2.3402 (1.6); 2.3310 (0.7); 2.3274 (0.8); 2.3180 (0.7); 2.3055 (0.8); 2.2929 (1.2); 2.2816 (1.3); 2.2765 (1.2); 2.2694 (2.0); 2.2548 (1.0); 2.2483 (1.4); 2.2406 (1.2); 2.2352 (1.2); 2.2274 (0.7); 2.2204 (0.9); 2.2136 (1.1); 2.2014 (0.4); 2.1911 (0.5); 2.1777 (0.4); 2.1716 (0.8); 2.1601 (0.6); 2.1483 (0.7); 2.1411 (0.7); 2.1366 (0.5); 2.1291 (0.3); 2.1217 (0.4); 2.1171 (0.5); 1.8401 (0.4); 1.8346 (0.4); 1.8282 (0.5); 1.8239 (0.5); 1.8169 (0.8); 1.8045 (0.8); 1.7970 (0.6); 1.7930 (0.7); 1.7857 (0.6); 1.7749 (0.4); 1.7659 (0.6); 1.7445 (1.2); 1.7343 (0.6); 1.7243 (1.1); 1.7131 (1.1); 1.7043 (0.5); 1.6928 (1.0); 1.6728 (0.3); 0.0082 (0.6) I.1-255:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.9634 (3.8); 8.9592 (4.2); 8.9523 (4.1); 8.9481 (4.0); 8.6792 (1.2); 8.6644 (2.4); 8.6498 (1.2); 8.5056 (2.4); 8.4860 (2.5); 8.0392 (4.6); 8.0175 (5.3); 7.8521 (4.7); 7.8490 (4.9); 7.7265 (3.7); 7.7217 (3.4); 7.7047 (3.2); 7.6998 (3.0); 7.6571 (3.4); 7.6460 (3.4); 7.6363 (3.3); 7.6253 (3.3); 7.3786 (0.7); 7.3747 (0.8); 7.3581 (1.6); 7.3542 (1.7); 7.3480 (0.9); 7.3384 (1.2); 7.3324 (1.7); 7.3280 (1.4); 7.3119 (0.9); 7.3079 (0.9); 7.2057 (0.9); 7.2018 (1.0); 7.1929 (1.0); 7.1891 (1.2); 7.1857 (1.8); 7.1821 (1.9); 7.1730 (1.7); 7.1696 (2.0); 7.1655 (1.2); 7.1615 (1.2); 7.1526 (1.0); 7.1491 (1.0); 7.0861 (1.9); 7.0701 (2.5); 7.0668 (2.4); 7.0507 (1.3); 4.7617 (2.8); 4.7221 (3.2); 4.5217 (0.8); 4.5074 (0.8); 4.4832 (2.8); 4.4686 (2.9); 4.4590 (2.8); 4.4447 (2.9); 4.4201 (0.9); 4.4059 (0.9); 4.2547 (3.8); 4.2150 (3.4); 4.0404 (0.8); 3.8749 (1.0); 3.8643 (1.6); 3.8539 (2.1); 3.8437 (2.4); 3.8337 (2.0); 3.8234 (1.5); 3.8128 (0.9); 3.1679 (16.0); 3.1127 (0.8); 3.1007 (0.7); 3.0945 (0.8); 3.0825 (0.7); 2.7669 (1.3); 2.7553 (1.0); 2.6714 (0.6); 2.6668 (0.5); 2.6546 (2.2); 2.6435 (2.3); 2.6194 (2.8); 2.6083 (2.6); 2.5249 (1.0); 2.5202 (1.7); 2.5115 (31.3); 2.5069 (69.6); 2.5023 (97.9); 2.4977 (69.2); 2.4931 (31.2); 2.4155 (0.7); 2.3963 (1.0); 2.3919 (1.0); 2.3733 (1.9); 2.3547 (4.6); 2.3332 (4.3); 2.3245 (1.0); 2.3196 (2.7); 2.2979 (3.7); 2.2841 (1.9); 2.2733 (2.4); 2.2601 (2.3); 2.2558 (1.1); 2.2426 (0.9); 2.2314 (1.3); 2.2187 (1.3); 2.1855 (0.9); 2.1663 (1.4); 2.1617 (0.8); 2.1543 (1.1); 2.1472 (0.9); 2.1423 (1.2); 2.1351 (1.7); 2.1304 (1.0); 2.1232 (0.6); 2.1155 (1.0); 2.1108 (1.2); 2.0915 (0.6); 2.0746 (0.5); 1.8426 (0.8); 1.8305 (1.2); 1.8194 (1.6); 1.8091 (1.3); 1.7988 (1.3); 1.7879 (1.4); 1.7771 (0.9); 1.7642 (0.6); 1.1974 (1.6); 1.1792 (3.6); 1.1609 (1.6); 1.0511 (1.1); 1.0332 (0.5); 0.0080 (1.5); 0.0048 (0.5); 0.0040 (0.7); 0.0023 (2.0); -0.0002 (51.2); -0.0058 (0.6); - 0.0067 (0.5); -0.0085 (1.4) I.1-257:1H NMR (400.0MHz, d6-DMSO): δ= 8.2693 (1.6); 8.2496 (1.7); 7.7032 (0.5); 7.1433 (1.9); 7.1230 (8.1); 7.1112 (8.9); 7.0901 (1.8); 4.6608 (1.9); 4.6227 (2.1); 4.2432 (0.6); 4.2291 (0.9); 4.2196 (0.9); 4.2081 (1.0); 4.1854 (0.7); 4.0554 (2.2); 4.0176 (2.0); 3.7197 (0.7); 3.7093 (0.9); 3.6991 (1.1); 3.6890 (0.9); 3.6789 (0.7); 3.3480 (7.8); 3.1638 (0.5); 2.6744 (0.6); 2.6698 (0.9); 2.6652 (0.7); 2.5383 (0.8); 2.5336 (1.4); 2.5277 (2.5); 2.5234 (3.1); 2.5185 (4.0); 2.5099 (51.7); 2.5053 (112.9); 2.5007 (157.3); 2.4961 (109.6); 2.4915 (48.8); 2.4823 (1.8); 2.4607 (0.6); 2.4565 (0.7); 2.3472 (1.1); 2.3276 (1.8); 2.3051 (1.0); 2.2759 (16.0); 2.2542 (1.0); 2.2440 (1.1); 2.2302 (1.2); 2.2151 (1.7); 2.2019 (0.7); 2.1933 (1.7); 2.1811 (1.4); 2.1591 (1.2); 2.0320 (0.6); 2.0194 (0.6); 2.0081 (0.7); 2.0009 (0.9); 1.9759 (0.6); 1.7176 (0.6); 1.7057 (0.8); 1.6956 (0.7); 1.6840 (0.7); 1.6736 (0.7); 1.6001 (0.7); 1.5867 (0.8); 1.5106 (1.4); 1.4990 (1.9); 1.4854 (2.0); 1.4740 (1.3); 1.4632 (1.1); 0.8911 (9.8); 0.8748 (9.4); 0.8248 (9.9); 0.8086 (9.7); 0.0080 (1.7); 0.0048 (0.7); -0.0002 (54.7); -0.0085 (1.4) I.1-260:1H NMR (400.0MHz, d6-DMSO): δ= 8.6537 (0.6); 8.6390 (1.2); 8.6231 (0.6); 7.1471 (1.9); 7.1268 (7.1); 7.1127 (7.8); 7.0919 (1.9); 4.6712 (1.9); 4.6334 (2.1); 4.0155 (2.2); 3.9776 (1.9); 3.9324 (0.6); 3.9164 (0.7); 3.9077 (1.9); 3.8917 (1.8); 3.8830 (2.0); 3.8670 (1.9); 3.8583 (0.7); 3.8421 (0.6); 3.7341 (0.7); 3.7233 (0.9); 3.7124 (1.0); 3.7025 (0.9); 3.6916 (0.7); 3.3165 (134.4); 2.6698 (0.6); 2.6187 (1.4); 2.6077 (1.4); 2.5835 (1.6); 2.5727 (1.6); 2.5232 (1.5); 2.5185 (2.2); 2.5098 (35.4); 2.5052 (77.1); 2.5006 (107.8); 2.4960 (75.4); 2.4914 (33.8); 2.3548 (1.1); 2.3321 (1.3); 2.3277 (0.9); 2.3229 (0.6); 2.3128 (0.8); 2.2765 (16.0); 2.2627 (1.2); 2.2521 (1.4); 2.2460 (1.9); 2.2385 (1.3); 2.2232 (1.8); 2.2106 (2.0); 2.1966 (0.7); 2.1880 (1.4); 2.0577 (0.7); 2.0452 (0.6); 2.0337 (0.7); 2.0259 (0.9); 2.0212 (0.6); 2.0069 (0.5); 2.0019 (0.7); 1.6941 (0.6); 1.6833 (0.8); 1.6731 (0.7); 1.6616 (0.6); 1.6512 (0.7) I.1-261:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.2012 (2.2); 9.1931 (2.2); 8.3078 (0.5); 6.9931 (1.3); 6.9901 (1.4); 6.9720 (1.6); 6.9690 (1.4); 6.6578 (1.5); 6.6497 (1.5); 6.6446 (0.5); 6.6415 (0.5); 6.6365 (1.4); 6.6284 (1.4); 3.3219 (22.1); 3.2981 (0.5); 2.8333 (0.6); 2.8182 (0.5); 2.5193 (0.5); 2.5108 (5.1); 2.5062 (10.9); 2.5016 (15.3); 2.4970 (10.7); 2.4924 (4.9); 2.2171 (0.8); 2.1965 (0.7); 2.1831 (0.6); 2.0857 (2.9); 1.3266 (16.0); 1.3198 (15.8) I.1-262:1H NMR (400.0MHz, CDCl3): δ= 7.3405 (0.8); 7.3196 (1.0); 7.2610 (7.5); 7.1102 (0.9); 7.0893 (0.8); 7.0301 (0.6); 2.7640 (0.8); 1.3063 (16.0); -0.0002 (2.0) I.1-264:1H NMR (400.1 MHz, CDCl3): δ= 7.5180 (3.6); 7.3597 (0.5); 7.3096 (1.7); 7.3000 (0.5); 7.2886 (0.7); 7.2764 (1.1); 7.2593 (651.7); 7.1600 (0.9); 7.1551 (1.3); 7.1337 (9.7); 7.1290 (9.5); 7.1071 (1.1); 6.9954 (3.7); 5.2199 (0.9); 4.7489 (2.0); 4.7116 (2.4); 4.1742 (2.3); 4.1362 (2.0); 3.9797 (0.4); 3.9674 (0.8); 3.9567 (1.0); 3.9463 (1.2); 3.9367 (1.0); 3.9258 (0.8); 3.9148 (0.4); 3.6476 (0.4); 3.2344 (1.9); 2.5848 (1.7); 2.5737 (1.7); 2.5597 (0.5); 2.5480 (2.1); 2.5367 (2.4); 2.5158 (1.1); 2.4937 (0.9); 2.4732 (0.8); 2.4482 (1.0); 2.4336 (1.1); 2.4239 (1.3); 2.4098 (1.4); 2.3913 (0.4); 2.3810 (0.7); 2.3673 (0.8); 2.3356 (1.1); 2.3273 (16.0); 2.3043 (0.7); 2.2851 (1.0); 2.2806 (0.6); 2.2720 (0.6); 2.2662 (0.6); 2.2611 (0.7); 2.2528 (1.0); 2.2481 (0.6); 2.2424 (0.4); 2.2333 (0.6); 2.2285 (0.9); 2.2092 (0.4); 2.1851 (2.0); 2.1633 (2.0); 2.1482 (1.6); 2.1264 (1.7); 2.0039 (0.3); 1.8399 (0.5); 1.8265 (0.6); 1.8154 (0.8); 1.8052 (0.7); 1.8024 (0.7); 1.7931 (0.7); 1.7825 (0.7); 1.7719 (0.5); 1.7586 (0.4); 1.5393 (82.4); 1.4789 (0.4); 1.4609 (0.3); 1.4511 (0.3); 1.4276 (0.3); 1.4147 (0.4); 1.3335 (0.3); 1.2943 (0.4); 1.2849 (0.4); 1.2563 (1.2); 0.8344 (0.4); 0.8281 (0.4); 0.1462 (1.0); 0.0503 (0.5); 0.0081 (7.3); 0.0056 (2.4) I.1-265:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4139 (0.6); 8.3944 (0.7); 8.3892 (0.7); 8.3698 (0.6); 7.2063 (2.3); 7.1858 (4.4); 7.1433 (2.4); 7.1366 (2.5); 7.1226 (1.4); 7.1161 (1.3); 4.6958 (0.8); 4.6888 (0.8); 4.6576 (0.8); 4.6505 (0.8); 4.0206 (0.8); 4.0082 (0.8); 3.9825 (0.7); 3.9702 (0.7); 3.6079 (10.5); 3.6001 (10.4); 3.4905 (1.5); 2.8776 (0.8); 2.8602 (1.2); 2.8430 (0.9); 2.5648 (0.9); 2.5539 (0.9); 2.5312 (0.7); 2.5190 (1.2); 2.5101 (10.5); 2.5055 (22.5); 2.5009 (31.0); 2.4964 (21.7); 2.4918 (9.7); 2.3278 (0.6); 2.2528 (0.6); 2.2455 (0.7); 2.2389 (0.6); 2.2242 (0.7); 2.2106 (1.0); 2.1896 (0.6); 2.1862 (0.6); 2.0730 (0.9); 2.0203 (0.5); 1.5694 (0.5); 1.5361 (0.8); 1.5237 (0.5); 1.5112 (0.8); 1.4972 (1.1); 1.4838 (0.9); 1.4740 (0.6); 1.4616 (0.8); 1.1946 (16.0); 1.1773 (15.7); 0.8925 (4.5); 0.8780 (4.3); 0.8763 (4.3); 0.8308 (3.8); 0.8273 (4.0); 0.8146 (3.8); 0.8111 (3.7); - 0.0002 (10.9) I.1-266:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.6309 (6.1); 7.6256 (6.0); 7.4198 (2.8); 7.4144 (2.5); 7.3990 (3.4); 7.3936 (3.2); 7.2576 (4.1); 7.2367 (3.2); 4.6502 (2.0); 4.6093 (2.2); 4.2466 (2.5); 4.2057 (2.1); 3.9215 (0.8); 3.9106 (1.1); 3.9011 (1.3); 3.8909 (1.1); 3.8811 (0.9); 3.6266 (0.6); 3.6079 (1.2); 3.5902 (2.0); 3.5752 (2.1); 3.5575 (1.1); 3.5386 (0.6); 3.5206 (0.5); 3.3973 (85.9); 3.3434 (2.0); 3.2955 (1.1); 3.2378 (1.1); 3.2247 (1.1); 3.1676 (3.9); 3.1536 (2.2); 3.1397 (2.4); 3.1357 (2.4); 3.1218 (2.2); 3.1098 (1.3); 3.0466 (1.2); 3.0334 (1.8); 3.0214 (1.7); 3.0087 (1.8); 2.9945 (1.4); 2.9813 (0.9); 2.9495 (1.1); 2.9396 (1.1); 2.7673 (16.0); 2.7553 (14.9); 2.7390 (0.9); 2.7318 (0.7); 2.7162 (0.8); 2.6968 (0.7); 2.6897 (1.2); 2.6789 (0.9); 2.6745 (1.8); 2.6699 (2.0); 2.6652 (1.3); 2.5885 (0.6); 2.5490 (1.9); 2.5445 (2.7); 2.5400 (3.2); 2.5232 (6.3); 2.5186 (8.6); 2.5100 (101.4); 2.5053 (213.2); 2.5007 (293.0); 2.4961 (204.9); 2.4915 (90.3); 2.4497 (1.2); 2.4453 (2.5); 2.4407 (1.7); 2.4276 (1.2); 2.4095 (0.5); 2.4051 (1.2); 2.4003 (1.7); 2.3957 (1.6); 2.3915 (1.1); 2.3322 (1.8); 2.3275 (2.2); 2.3230 (2.1); 2.3183 (0.9); 2.3108 (1.4); 2.2995 (1.4); 2.2718 (1.9); 2.2628 (1.5); 2.2548 (0.8); 2.2485 (0.6); 2.2361 (1.0); 2.2120 (0.6); 2.0721 (1.7); 1.8409 (0.6); 1.8230 (1.4); 1.8037 (1.8); 1.7861 (1.9); 1.7666 (1.3); 1.7465 (0.6); 1.7347 (0.6); 1.0565 (7.1); 1.0385 (16.0); 1.0205 (6.8); 0.0489 (0.6); 0.0080 (2.7); -0.0002 (92.8); -0.0085 (2.5); -0.0505 (0.6) I.1-267:1H NMR (400.0MHz, d6-DMSO): δ= 8.3372 (0.6); 8.3233 (1.2); 8.3097 (0.6); 7.2057 (1.3); 7.2010 (1.5); 7.1902 (4.8); 7.1871 (5.4); 7.1837 (4.2); 7.1775 (3.2); 7.1744 (3.1); 7.1624 (2.5); 7.1573 (1.9); 7.1476 (1.2); 7.1413 (2.3); 7.1393 (2.2); 7.1372 (1.8); 7.1191 (6.2); 7.1019 (6.9); 7.0966 (1.5); 7.0813 (2.0); 4.6721 (1.7); 4.6342 (1.8); 4.2618 (4.2); 4.2479 (4.2); 4.0068 (1.9); 3.9689 (1.7); 3.7397 (0.6); 3.7288 (0.8); 3.7175 (0.9); 3.7083 (0.8); 3.6974 (0.7); 3.4652 (7.2); 3.1679 (0.8); 3.1523 (1.0); 2.6258 (1.4); 2.6069 (4.5); 2.5880 (5.1); 2.5743 (1.4); 2.5693 (1.7); 2.5505 (1.5); 2.5398 (1.5); 2.5232 (0.6); 2.5185 (0.8); 2.5098 (13.5); 2.5052 (29.7); 2.5006 (41.5); 2.4960 (29.2); 2.4914 (13.1); 2.3461 (1.0); 2.3273 (1.2); 2.3232 (1.0); 2.3040 (0.8); 2.2739 (13.9); 2.2577 (1.2); 2.2472 (1.2); 2.2336 (1.3); 2.2127 (1.6); 2.2054 (0.7); 2.1901 (1.7); 2.1779 (1.3); 2.1552 (1.2); 2.0624 (0.7); 2.0499 (0.5); 2.0383 (0.6); 2.0309 (0.8); 2.0260 (0.6); 2.0066 (0.6); 1.7386 (0.5); 1.7279 (0.8); 1.7175 (0.6); 1.7064 (0.6); 1.6959 (0.7); 1.1565 (6.9); 1.1377 (16.0); 1.1188 (6.8); - 0.0002 (8.2) I.1-268:1H NMR (400.0MHz, d6-DMSO): δ= 9.2274 (0.5); 8.9569 (1.1); 7.3921 (0.6); 7.3724 (1.2); 7.3495 (1.2); 7.3252 (0.7); 7.2149 (0.6); 7.1946 (1.3); 7.1825 (1.4); 7.1645 (0.7); 7.0621 (1.1); 7.0468 (1.6); 7.0274 (0.8); 4.6753 (1.0); 4.6347 (1.2); 4.2501 (2.1); 4.2095 (1.9); 3.8530 (1.2); 3.5683 (4.2); 3.2012 (0.8); 3.1826 (2.3); 3.1666 (3.8); 3.1511 (2.4); 3.0606 (2.8); 2.9520 (9.6); 2.7495 (16.0); 2.7376 (14.6); 2.6877 (1.5); 2.6794 (1.7); 2.6700 (1.6); 2.6654 (1.1); 2.5235 (3.9); 2.5188 (5.7); 2.5101 (84.2); 2.5056 (183.0); 2.5010 (256.0); 2.4963 (179.1); 2.4918 (79.4); 2.4501 (0.8); 2.4270 (0.8); 2.4065 (1.5); 2.3836 (2.0); 2.3654 (1.8); 2.3424 (1.5); 2.3279 (1.6); 2.3003 (0.9); 2.2874 (1.1); 2.2760 (1.4); 2.2631 (1.4); 2.2338 (0.9); 2.2225 (0.9); 2.1583 (1.0); 2.0733 (0.7); 1.8751 (1.6); 1.8569 (2.0); 1.8374 (1.7); 1.8215 (1.2); 1.8104 (1.1); 1.7909 (1.0); 1.7796 (0.8); 1.0969 (5.9); 1.0787 (12.4); 1.0605 (5.5); 0.0081 (1.7); -0.0002 (57.4); -0.0086 (1.5) I.1-269:1H NMR (400.1 MHz, i.e6-DMSO): δ= 11.5018 (1.1); 7.4091 (1.5); 7.4045 (0.5); 7.3930 (0.6); 7.3882 (2.2); 7.2648 (1.7); 7.2438 (1.3); 4.6430 (0.6); 4.6040 (0.7); 4.1229 (0.7); 4.0840 (0.6); 3.7497 (0.3); 3.3748 (11.4); 3.1681 (1.3); 2.7710 (16.0); 2.7166 (0.4); 2.7062 (0.4); 2.6791 (0.5); 2.6687 (0.5); 2.5110 (4.2); 2.5066 (9.2); 2.5021 (13.0); 2.4976 (9.5); 2.4931 (4.5); 2.3897 (0.3); 2.3552 (0.5); 2.3330 (0.5); 2.3177 (0.4); 2.2953 (0.4); 2.2917 (0.4); 2.2806 (0.4); 2.2670 (0.3) I.1-270:1H NMR (400.1 MHz, CDCl3): δ= 7.5235 (0.5); 7.5202 (0.6); 7.3105 (0.4); 7.2647 (84.8); 7.2614 (108.9); 7.1263 (0.9); 7.1132 (1.9); 7.1012 (3.7); 7.0931 (2.9); 7.0767 (5.6); 7.0705 (4.3); 7.0592 (16.0); 7.0489 (13.5); 7.0393 (4.9); 7.0199 (0.4); 7.0008 (0.4); 6.9974 (0.6); 5.7716 (0.7); 5.5327 (3.5); 5.3018 (1.7); 5.2985 (2.2); 4.8712 (1.1); 4.8405 (6.8); 4.8017 (7.5); 4.3545 (1.4); 4.3160 (1.2); 4.2790 (8.2); 4.2402 (7.1); 4.0405 (0.3); 4.0285 (0.5); 4.0196 (0.6); 4.0102 (0.5); 3.9891 (1.3); 3.9777 (2.3); 3.9687 (3.2); 3.9579 (4.3); 3.9472 (3.3); 3.9367 (2.4); 3.9262 (1.1); 3.2418 (0.4); 2.8976 (0.7); 2.8883 (0.7); 2.8575 (0.9); 2.8482 (0.9); 2.7045 (0.7); 2.6967 (1.7); 2.6870 (3.0); 2.6788 (4.0); 2.6695 (4.1); 2.6606 (3.0); 2.6519 (1.8); 2.6429 (0.7); 2.5719 (4.5); 2.5606 (4.5); 2.5494 (1.6); 2.5351 (6.1); 2.5250 (6.5); 2.5064 (5.2); 2.4855 (4.6); 2.4642 (4.9); 2.4425 (3.7); 2.4283 (3.5); 2.4186 (4.0); 2.4040 (5.1); 2.3880 (1.5); 2.3755 (2.4); 2.3617 (2.4); 2.3254 (1.8); 2.3064 (3.0); 2.2926 (2.3); 2.2867 (2.3); 2.2830 (2.2); 2.2739 (3.4); 2.2687 (2.0); 2.2535 (2.5); 2.2309 (1.3); 2.1439 (6.2); 2.1221 (6.5); 2.1076 (6.1); 2.0859 (5.9); 1.8772 (1.5); 1.8662 (2.6); 1.8537 (2.7); 1.8431 (3.0); 1.8325 (3.2); 1.8213 (2.7); 1.8098 (2.5); 1.7957 (1.4); 1.7767 (0.4); 0.8358 (0.3); 0.8164 (1.1); 0.7959 (3.3); 0.7818 (11.2); 0.7786 (10.4); 0.7671 (9.8); 0.7644 (11.0); 0.7609 (8.0); 0.7496 (3.0); 0.7236 (0.3); 0.5735 (0.3); 0.5480 (2.1); 0.5215 (0.5); 0.5116 (0.5); 0.4807 (2.9); 0.4665 (10.5); 0.4620 (9.6); 0.4574 (9.6); 0.4428 (2.5); 0.0117 (0.9); 0.0034 (31.3); 0.0000 (41.4) I.1-271:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.3435 (2.0); 8.3224 (2.0); 7.2816 (0.8); 7.2632 (2.1); 7.2436 (3.1); 7.2403 (2.8); 7.2362 (2.8); 7.2216 (8.3); 7.2155 (8.5); 7.1993 (4.2); 7.1865 (1.6); 7.1818 (1.9); 7.1656 (0.8); 7.1268 (4.0); 7.1071 (7.9); 7.0806 (3.2); 7.0564 (6.0); 7.0363 (3.2); 4.5971 (2.0); 4.5591 (2.4); 4.4465 (0.9); 4.4347 (0.9); 4.4207 (1.0); 4.4143 (1.0); 4.4008 (0.7); 4.3886 (0.6); 3.9902 (1.0); 3.9532 (0.9); 3.8746 (1.9); 3.8365 (1.8); 3.5636 (1.1); 3.5520 (1.1); 3.5320 (0.6); 3.3360 (242.8); 3.1673 (0.7); 3.0881 (1.2); 3.0764 (1.2); 3.0535 (1.6); 3.0416 (1.4); 2.8338 (1.4); 2.8078 (1.4); 2.7993 (1.4); 2.7738 (1.0); 2.6746 (1.1); 2.6700 (1.6); 2.6655 (1.1); 2.5403 (1.5); 2.5234 (4.1); 2.5187 (6.4); 2.5101 (94.9); 2.5055 (203.7); 2.5009 (281.8); 2.4964 (196.3); 2.4918 (88.0); 2.4786 (2.8); 2.4680 (1.8); 2.4556 (1.1); 2.4444 (1.6); 2.4344 (1.3); 2.3323 (1.2); 2.3278 (1.5); 2.3232 (1.1); 2.2707 (16.0); 2.2521 (1.4); 2.2312 (1.6); 2.2100 (1.1); 2.1844 (1.1); 2.1715 (1.3); 2.1606 (1.4); 2.1473 (1.4); 2.1240 (1.4); 2.1011 (1.6); 2.0903 (1.5); 2.0672 (1.3); 2.0588 (0.8); 2.0365 (0.6); 1.8766 (0.7); 1.8522 (0.7); 1.8441 (0.8); 1.8198 (0.7); 1.6454 (0.6); 1.6341 (0.8); 1.6124 (0.8); 1.6027 (0.7); -0.0002 (6.5) I.1-272:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.3528 (2.1); 8.3320 (2.2); 7.2819 (1.4); 7.2636 (3.2); 7.2612 (3.2); 7.2511 (1.5); 7.2441 (4.1); 7.2411 (3.4); 7.2368 (2.6); 7.2213 (7.7); 7.2166 (8.9); 7.1999 (5.0); 7.1866 (2.5); 7.1824 (2.1); 7.1695 (1.1); 7.1661 (1.0); 7.1271 (4.1); 7.1072 (8.2); 7.0803 (5.0); 7.0561 (4.8); 7.0357 (2.5); 4.5973 (2.2); 4.5593 (2.5); 4.4706 (0.6); 4.4572 (0.8); 4.4450 (1.0); 4.4330 (0.8); 4.4241 (1.0); 4.4120 (0.7); 4.3986 (0.6); 3.9909 (1.7); 3.9528 (1.6); 3.8720 (1.7); 3.8340 (1.7); 3.6006 (1.5); 3.5897 (1.7); 3.5799 (2.0); 3.5700 (2.1); 3.5596 (2.1); 3.5498 (2.0); 3.5411 (1.9); 3.5300 (1.7); 3.3683 (99.8); 3.1676 (0.9); 3.0881 (1.5); 3.0770 (1.6); 3.0535 (1.9); 3.0428 (1.8); 2.8321 (1.9); 2.8265 (2.0); 2.7990 (2.4); 2.7921 (2.0); 2.7721 (1.8); 2.7665 (1.9); 2.6751 (2.0); 2.6707 (2.2); 2.6661 (2.1); 2.6047 (1.7); 2.5523 (2.1); 2.5408 (2.4); 2.5240 (4.5); 2.5193 (5.9); 2.5105 (48.9); 2.5061 (105.5); 2.5016 (148.6); 2.4971 (117.4); 2.4929 (62.4); 2.4790 (4.2); 2.4681 (2.3); 2.4543 (2.8); 2.4443 (2.9); 2.4341 (1.7); 2.3329 (1.0); 2.3284 (1.3); 2.3238 (1.1); 2.2921 (0.9); 2.2676 (16.0); 2.2507 (1.9); 2.2302 (1.9); 2.2088 (1.2); 2.1841 (1.3); 2.1706 (1.4); 2.1603 (1.6); 2.1463 (1.5); 2.1228 (1.3); 2.1002 (1.4); 2.0895 (1.6); 2.0738 (0.7); 2.0666 (1.5); 2.0573 (1.1); 2.0347 (0.9); 1.8716 (0.5); 1.8511 (0.6); 1.8424 (0.7); 1.8191 (0.6); 1.7616 (0.5); 1.7376 (0.6); 1.7295 (0.6); 1.7054 (0.6); 1.6330 (0.6); 1.6228 (0.6); 1.6110 (0.6); 1.3789 (0.6); 1.3669 (0.6); 1.3562 (0.6); 1.3466 (0.5); -0.0002 (10.1) I.1-273:1H NMR (400.0MHz, d6-DMSO): δ= 7.1483 (1.9); 7.1279 (7.7); 7.1155 (8.4); 7.1097 (1.4); 7.0947 (1.8); 4.6871 (1.1); 4.6812 (1.1); 4.6494 (1.3); 4.6431 (1.3); 4.6360 (1.1); 4.6211 (2.0); 4.6055 (2.0); 4.5908 (1.0); 4.0424 (2.2); 4.0043 (2.0); 3.7107 (0.6); 3.7002 (1.0); 3.6898 (1.0); 3.6793 (1.0); 3.6687 (0.7); 3.4052 (2.2); 3.3714 (124.8); 3.3330 (1.0); 2.7638 (0.8); 2.7541 (0.9); 2.7429 (0.8); 2.7334 (0.8); 2.7247 (1.1); 2.7151 (1.0); 2.7042 (1.0); 2.6947 (1.0); 2.6714 (0.5); 2.5412 (0.8); 2.5364 (1.2); 2.5320 (1.3); 2.5248 (1.8); 2.5200 (2.5); 2.5114 (32.7); 2.5069 (68.3); 2.5023 (91.6); 2.4977 (63.3); 2.4931 (28.1); 2.4211 (1.3); 2.4160 (0.7); 2.4080 (1.4); 2.3988 (1.7); 2.3923 (0.8); 2.3854 (1.3); 2.3823 (1.4); 2.3740 (1.0); 2.3689 (1.4); 2.3601 (1.1); 2.3467 (1.0); 2.3291 (0.6); 2.2947 (0.6); 2.2914 (0.7); 2.2745 (16.0); 2.2532 (1.0); 2.2143 (0.5); 2.1448 (0.7); 2.1324 (0.6); 2.1266 (0.5); 2.1198 (0.6); 2.1143 (0.8); 2.1078 (0.6); 2.0947 (0.5); 2.0882 (0.6); 1.7223 (0.5); 1.7145 (0.8); 1.7051 (1.2); 1.6969 (1.2); 1.6911 (1.2); 1.6828 (1.4); 1.6730 (1.1); 1.6654 (0.8); 1.6624 (0.8); 1.6580 (0.6); 1.6499 (0.5); 1.0743 (8.5); 1.0722 (8.4); 1.0583 (8.5); 1.0563 (8.2); 0.8325 (12.6); 0.8288 (13.0); 0.8154 (12.2); 0.8118 (12.5); 0.0080 (0.9); -0.0002 (29.8); -0.0085 (0.8) I.1-274:1H NMR (400.1 MHz, CDCl3): δ= 7.5186 (0.3); 7.2713 (4.3); 7.2617 (44.5); 7.2599 (59.8); 7.1445 (0.3); 7.1231 (16.0); 5.9312 (0.6); 4.7441 (1.5); 4.7064 (1.7); 4.1310 (1.7); 4.0934 (1.5); 3.9549 (0.6); 3.9453 (0.7); 3.9345 (1.0); 3.9243 (0.7); 3.9138 (0.5); 3.7114 (1.2); 3.7003 (14.3); 3.4938 (0.5); 3.4793 (1.6); 3.4639 (2.2); 3.4485 (1.5); 3.4334 (0.5); 2.5368 (0.4); 2.5269 (1.3); 2.5152 (3.2); 2.5005 (3.6); 2.4920 (2.1); 2.4855 (2.2); 2.4794 (1.4); 2.4520 (0.6); 2.4262 (0.6); 2.4121 (0.7); 2.4017 (0.8); 2.3878 (0.8); 2.3593 (0.4); 2.3447 (0.5); 2.3270 (11.7); 2.2294 (0.6); 2.2160 (0.4); 2.2054 (0.5); 2.1971 (0.6); 2.1773 (0.4); 2.1727 (0.5); 2.1089 (1.1); 2.0874 (1.1); 2.0726 (0.9); 2.0513 (0.9); 1.7948 (0.5); 1.7828 (0.6); 1.7734 (0.6); 1.7596 (0.5); 1.7502 (0.5); 1.7390 (0.3); 1.5615 (2.1); 1.5526 (19.2); 1.5505 (24.4); 0.0102 (2.0); 0.0081 (2.1); 0.0019 (18.8); 0.0000 (25.6) I.1-275:1H NMR (400.0MHz, d6-DMSO): δ= 7.6323 (15.5); 7.6269 (16.0); 7.4182 (7.1); 7.4128 (6.6); 7.3974 (8.9); 7.3920 (8.5); 7.2503 (10.9); 7.2294 (8.6); 7.1902 (4.7); 7.0585 (10.3); 6.9268 (5.3); 4.6082 (6.2); 4.5669 (7.6); 4.2451 (7.3); 4.2038 (6.1); 3.8757 (1.4); 3.8659 (2.2); 3.8559 (2.9); 3.8460 (3.2); 3.8343 (3.0); 3.8243 (2.5); 3.8145 (1.3); 3.1693 (1.0); 2.7965 (3.6); 2.7869 (3.8); 2.7570 (4.8); 2.7473 (4.5); 2.6704 (0.6); 2.5280 (4.8); 2.5241 (2.3); 2.5192 (2.3); 2.5105 (34.0); 2.5059 (76.5); 2.5013 (100.6); 2.4966 (70.6); 2.4920 (33.0); 2.4661 (4.1); 2.4595 (0.8); 2.4530 (1.5); 2.4506 (1.4); 2.4447 (1.3); 2.4374 (1.1); 2.4292 (3.5); 2.4110 (2.9); 2.4067 (2.6); 2.3981 (1.1); 2.3897 (1.4); 2.3760 (0.9); 2.3326 (0.8); 2.3273 (2.4); 2.3150 (2.2); 2.3028 (3.7); 2.2909 (3.6); 2.2615 (5.5); 2.2518 (3.7); 2.2409 (2.1); 2.2344 (1.6); 2.2224 (2.9); 2.2169 (1.4); 2.2102 (1.0); 2.2029 (1.6); 2.1980 (1.7); 2.1787 (0.8); 2.0854 (1.1); 2.0721 (1.2); 1.8182 (0.6); 1.7942 (2.4); 1.7829 (1.8); 1.7725 (2.9); 1.7647 (1.5); 1.7605 (1.5); 1.7555 (1.6); 1.7511 (1.6); 1.7405 (1.6); 1.7290 (1.0); -0.0002 (17.4); -0.0085 (0.6) I.1-276:1H NMR (400.0MHz, d6-DMSO): δ= 12.7513 (0.8); 8.3582 (1.4); 8.3380 (1.7); 8.3201 (0.5); 7.2799 (1.5); 7.2617 (3.3); 7.2591 (2.6); 7.2494 (1.4); 7.2441 (4.1); 7.2321 (1.2); 7.2146 (6.6); 7.2063 (5.1); 7.1980 (7.6); 7.1944 (7.8); 7.1855 (2.9); 7.1678 (1.0); 7.1598 (1.3); 7.1537 (1.0); 7.1409 (2.0); 7.1343 (1.5); 7.1258 (1.0); 7.1194 (0.9); 7.0800 (2.7); 7.0610 (1.7); 4.7136 (2.0); 4.6747 (2.1); 4.4937 (0.5); 4.4813 (0.7); 4.4684 (0.9); 4.4606 (0.8); 4.4475 (0.7); 4.4355 (0.7); 4.0224 (1.7); 3.9826 (1.8); 3.9401 (0.6); 3.5620 (0.9); 3.3136 (215.0); 3.2630 (0.6); 3.1651 (0.6); 3.0917 (0.9); 3.0792 (1.2); 3.0564 (1.2); 3.0445 (1.3); 2.8333 (1.3); 2.8081 (1.4); 2.7992 (1.2); 2.7737 (1.1); 2.6788 (0.7); 2.6743 (1.6); 2.6697 (2.3); 2.6651 (1.6); 2.6605 (0.8); 2.5958 (1.0); 2.5829 (2.3); 2.5785 (2.4); 2.5639 (2.3); 2.5400 (1.1); 2.5232 (5.2); 2.5185 (8.0); 2.5098 (132.6); 2.5052 (291.5); 2.5006 (408.6); 2.4960 (288.1); 2.4914 (129.1); 2.4737 (2.5); 2.4499 (3.2); 2.4403 (2.2); 2.4002 (0.6); 2.3366 (1.2); 2.3321 (1.9); 2.3275 (2.7); 2.3228 (1.9); 2.2943 (1.0); 2.2715 (1.4); 2.2492 (0.8); 2.2006 (1.0); 2.1899 (1.1); 2.1760 (1.2); 2.1615 (2.1); 2.1478 (0.8); 2.1386 (1.5); 2.1266 (1.7); 2.1042 (1.0); 2.0730 (0.6); 1.8077 (0.6); 1.7850 (0.7); 1.7736 (0.7); 1.7530 (0.6); 1.4179 (0.7); 1.4088 (0.8); 1.1223 (7.0); 1.1035 (16.0); 1.0847 (6.8); 0.1462 (0.6); 0.0080 (5.8); 0.0063 (1.9); 0.0054 (2.3); - 0.0002 (189.8); -0.0060 (1.8); -0.0068 (1.5); -0.0085 (5.3); -0.0506 (0.8); -0.1496 (0.6) I.1-277:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1453 (0.7); 7.1245 (3.7); 7.1170 (2.6); 7.1122 (2.3); 7.0962 (0.5); 4.6622 (0.8); 4.6239 (0.8); 4.0234 (0.8); 3.3765 (0.7); 3.3272 (115.7); 3.1665 (0.6); 2.6745 (0.6); 2.6699 (0.9); 2.6653 (0.6); 2.5549 (0.5); 2.5503 (0.7); 2.5454 (0.9); 2.5402 (0.8); 2.5342 (0.8); 2.5234 (2.5); 2.5187 (3.5); 2.5100 (47.9); 2.5054 (103.6); 2.5008 (145.0); 2.4962 (101.4); 2.4916 (45.3); 2.4715 (0.9); 2.4629 (0.6); 2.3323 (0.9); 2.3276 (1.1); 2.3229 (0.7); 2.2761 (7.4); 2.0270 (16.0); -0.0002 (14.6) I.1-278:1H NMR (400.0MHz, d6-DMSO): δ= 12.7174 (1.1); 8.3395 (1.6); 8.3182 (1.5); 7.2541 (1.2); 7.2372 (2.9); 7.2324 (2.4); 7.2198 (7.2); 7.2061 (9.6); 7.2019 (7.3); 7.1945 (3.4); 7.1911 (3.3); 7.1858 (2.8); 7.1659 (1.3); 7.1464 (1.8); 7.1405 (1.7); 7.1311 (1.0); 7.1248 (1.1); 7.0804 (2.5); 7.0625 (1.7); 4.7166 (2.1); 4.6783 (2.2); 4.4073 (0.9); 4.3741 (0.6); 3.9794 (2.0); 3.9397 (1.8); 3.5354 (1.1); 3.3636 (1.2); 3.3131 (528.4); 3.2523 (0.6); 3.1666 (1.2); 3.0775 (1.0); 3.0665 (1.0); 3.0429 (1.4); 3.0312 (1.1); 2.8299 (1.3); 2.8050 (1.3); 2.7963 (1.2); 2.7714 (1.1); 2.6789 (1.7); 2.6743 (3.5); 2.6697 (5.0); 2.6650 (3.5); 2.6605 (1.6); 2.5918 (1.2); 2.5747 (2.8); 2.5640 (1.3); 2.5527 (3.5); 2.5400 (4.9); 2.5232 (13.4); 2.5185 (19.6); 2.5098 (276.2); 2.5052 (600.5); 2.5006 (843.5); 2.4960 (590.3); 2.4914 (260.2); 2.4472 (1.6); 2.4368 (1.6); 2.3981 (0.6); 2.3366 (1.6); 2.3320 (3.4); 2.3275 (5.0); 2.3228 (3.7); 2.3001 (0.9); 2.2799 (0.8); 2.2584 (1.3); 2.2345 (0.7); 2.2018 (0.8); 2.1909 (1.2); 2.1847 (1.5); 2.1769 (1.1); 2.1609 (1.8); 2.1501 (1.5); 2.1265 (1.6); 2.0730 (2.0); 1.8728 (0.8); 1.8530 (0.7); 1.6909 (0.9); 1.1217 (6.9); 1.1030 (16.0); 1.0841 (6.7); 0.1458 (1.1); 0.0080 (10.9); 0.0062 (3.0); 0.0054 (3.4); -0.0002 (419.6); -0.0060 (4.4); -0.0069 (3.8); -0.0085 (12.4); -0.0156 (1.2); -0.0204 (0.7); -0.1496 (1.2) I.1-280:1H NMR (400.1 MHz, d6-DMSO): δ= 17.6767 (1.3); 16.6147 (1.9); 16.6008 (1.6); 12.3224 (2.0); 12.2518 (1.4); 11.4451 (1.3); 8.2865 (1.2); 7.3927 (2.5); 7.3808 (5.4); 7.3686 (5.8); 7.3604 (7.0); 7.3461 (6.6); 7.2003 (1.5); 7.1932 (6.2); 7.1709 (12.2); 7.1666 (5.1); 7.1493 (6.2); 7.1445 (5.4); 7.1211 (2.5); 5.1036 (2.0); 5.0764 (3.5); 5.0688 (1.7); 5.0583 (3.4); 5.0413 (1.9); 5.0377 (1.2); 3.9960 (1.2); 3.9788 (1.4); 3.9719 (1.3); 3.6203 (2.0); 3.6157 (1.6); 3.5967 (2.3); 3.5775 (1.5); 3.3804 (3.1); 3.3307 (519.4); 3.2798 (2.6); 3.1668 (4.0); 2.6750 (6.0); 2.6712 (7.1); 2.6660 (5.7); 2.6381 (2.6); 2.6295 (2.8); 2.5980 (3.4); 2.5900 (3.2); 2.5604 (2.9); 2.5562 (5.1); 2.5514 (6.5); 2.5470 (4.3); 2.5242 (17.1); 2.5194 (25.7); 2.5107 (465.4); 2.5062 (1018.1); 2.5017 (1408.0); 2.4971 (1005.3); 2.4927 (461.8); 2.4571 (6.7); 2.4516 (5.8); 2.4472 (4.1); 2.4169 (4.9); 2.3987 (4.5); 2.3825 (1.7); 2.3738 (4.0); 2.3590 (3.7); 2.3380 (8.9); 2.3336 (8.1); 2.3283 (7.7); 2.3242 (5.9); 2.1939 (2.0); 2.1842 (2.2); 2.1703 (4.4); 2.1603 (3.7); 2.1437 (3.0); 2.1286 (3.9); 2.1201 (4.1); 2.1032 (1.3); 2.0854 (1.4); 2.0753 (3.4); 2.0644 (1.8); 2.0545 (2.8); 2.0297 (3.2); 2.0131 (2.4); 1.9892 (1.6); 1.6894 (1.4); 1.6579 (2.6); 1.6513 (2.6); 1.6275 (1.6); 1.5830 (6.7); 1.5652 (6.7); 1.5353 (16.0); 1.5172 (15.6); 1.3476 (1.2); 0.3393 (1.2); 0.1463 (1.7); 0.0084 (8.3) I.1-282:1H NMR (400.1 MHz, i.e6-DMSO): δ= 19.9309 (0.5); 16.9434 (0.6); 16.3191 (0.5); 16.2540 (0.7); 15.0797 (0.6); 12.5949 (0.6); 11.9690 (1.2); 11.9603 (1.3); 11.9296 (0.6); 11.1973 (0.6); 9.2239 (0.5); 8.2723 (1.9); 8.2527 (2.0); 7.3711 (1.6); 7.3506 (3.2); 7.3354 (3.7); 7.3312 (2.6); 7.3153 (2.2); 7.1370 (4.0); 7.1186 (5.2); 7.0899 (2.3); 7.0506 (1.7); 7.0458 (1.4); 7.0288 (2.8); 7.0086 (1.5); 7.0022 (1.4); 4.9424 (0.6); 4.9261 (1.8); 4.9076 (2.6); 4.8897 (2.0); 4.7848 (0.5); 4.7193 (3.3); 4.7055 (3.3); 3.8206 (0.9); 3.8076 (1.4); 3.7859 (1.6); 3.7793 (1.4); 3.5764 (0.6); 3.3556 (1.5); 3.3444 (1.0); 3.3060 (784.9); 3.1750 (0.8); 3.1626 (0.8); 2.6739 (1.9); 2.6689 (2.0); 2.6645 (1.7); 2.5536 (0.6); 2.5230 (3.5); 2.5180 (4.8); 2.5093 (131.4); 2.5047 (290.5); 2.5002 (407.7); 2.4956 (290.0); 2.4910 (133.9); 2.4196 (0.6); 2.4013 (0.6); 2.3432 (1.3); 2.3314 (2.7); 2.3273 (2.8); 2.3217 (2.4); 2.3055 (2.6); 2.2969 (3.0); 2.2930 (2.8); 2.2838 (2.4); 2.2675 (1.0); 2.2553 (3.5); 2.2351 (4.5); 2.2219 (2.2); 2.1980 (2.8); 2.1802 (1.4); 2.1723 (2.0); 2.1639 (1.3); 2.1565 (1.6); 2.1516 (1.2); 2.1353 (1.2); 2.1194 (0.8); 2.1115 (0.5); 2.0709 (1.2); 1.6935 (1.0); 1.6590 (1.4); 1.6431 (1.7); 1.6338 (1.4); 1.6246 (1.1); 1.6088 (0.9); 1.5736 (0.8); 1.5506 (1.4); 1.5356 (1.7); 1.5156 (1.6); 1.5031 (0.9); 1.4952 (0.9); 1.4791 (0.7); 1.3276 (15.8); 1.3101 (16.0); 1.2351 (0.6); 0.1467 (0.6); 0.0078 (2.1) I.1-283:1H NMR (400.0MHz, d6-DMSO): δ= 7.1442 (2.1); 7.1238 (7.3); 7.1119 (3.4); 7.1044 (4.1); 7.0852 (1.7); 7.0616 (0.8); 4.7118 (0.6); 4.6744 (0.7); 4.6221 (0.6); 4.5910 (0.7); 4.5177 (0.6); 4.4877 (0.7); 4.1884 (0.9); 4.0780 (0.8); 4.0405 (0.7); 3.9924 (0.7); 3.7313 (0.8); 3.6440 (0.8); 3.6195 (0.7); 3.4882 (1.4); 3.3733 (218.5); 3.1679 (2.5); 2.7418 (0.8); 2.6750 (1.6); 2.6702 (2.3); 2.6656 (1.8); 2.5405 (0.8); 2.5236 (5.2); 2.5189 (7.5); 2.5103 (118.5); 2.5057 (260.9); 2.5011 (365.3); 2.4965 (254.0); 2.4919 (113.7); 2.4559 (1.6); 2.4511 (2.0); 2.4465 (1.5); 2.3859 (1.0); 2.3473 (1.0); 2.3325 (1.9); 2.3279 (2.6); 2.3233 (2.0); 2.2749 (16.0); 2.2381 (1.4); 2.0727 (2.1); 1.9136 (1.6); 1.8673 (1.4); 1.8488 (1.7); 1.6495 (0.8); 1.0627 (0.6); -0.0002 (14.8) I.1-284:1H NMR (400.0 MHz, i.e6-DMSO): δ= 12.2226 (1.3); 8.4673 (1.8); 8.4522 (3.3); 8.4376 (1.8); 7.9438 (1.0); 7.9228 (1.2); 7.8145 (1.5); 7.7926 (15.1); 7.7881 (5.3); 7.7761 (5.5); 7.7715 (16.0); 7.6553 (1.0); 7.6339 (0.9); 7.4330 (13.6); 7.4118 (12.3); 5.6780 (0.8); 5.6629 (1.4); 5.6391 (2.7); 5.6242 (9.3); 5.6211 (5.0); 5.6158 (3.3); 5.6104 (4.8); 5.6074 (9.7); 5.5926 (3.3); 5.5853 (1.4); 5.5813 (1.9); 5.5772 (1.2); 5.5714 (1.3); 5.5688 (1.8); 5.5540 (0.9); 4.7066 (0.5); 4.6662 (0.6); 4.3367 (11.4); 4.3216 (11.2); 4.2817 (0.6); 4.2423 (0.6); 4.1569 (0.5); 4.1437 (0.5); 3.3412 (37.7); 3.0073 (10.6); 3.0045 (9.4); 2.9997 (5.5); 2.9940 (14.2); 2.9505 (11.6); 2.9368 (9.4); 2.6751 (0.8); 2.6703 (1.2); 2.6387 (0.5); 2.6287 (0.6); 2.5237 (3.7); 2.5188 (5.6); 2.5103 (57.2); 2.5058 (118.6); 2.5012 (161.2); 2.4966 (114.3); 2.4921 (52.3); 2.4672 (0.8); 2.4613 (0.9); 2.4177 (0.6); 2.3938 (0.6); 2.3492 (0.7); 2.3373 (0.7); 2.3326 (1.0); 2.3277 (1.4); 2.3233 (1.0); 2.3092 (0.7); 2.2961 (0.5); 2.2870 (0.6); 2.2825 (0.5); -0.0002 (6.6) I.1-285:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.8174 (0.6); 7.7987 (0.5); 7.3539 (0.6); 7.3317 (0.6); 7.1883 (0.6); 7.1846 (0.7); 7.1722 (0.7); 7.0709 (0.6); 7.0548 (0.9); 4.7290 (1.0); 4.6893 (1.2); 4.2374 (1.3); 4.1974 (1.1); 3.8137 (0.6); 3.8078 (0.5); 3.7974 (1.3); 3.7873 (0.9); 3.7785 (1.2); 3.7669 (0.6); 3.7624 (0.6); 3.3212 (46.0); 2.5232 (0.5); 2.5185 (0.8); 2.5098 (16.1); 2.5053 (35.6); 2.5007 (49.9); 2.4961 (35.5); 2.4916 (16.4); 2.4664 (1.1); 2.4543 (1.1); 2.4317 (1.2); 2.4197 (1.1); 2.3571 (0.8); 2.3372 (0.8); 2.3149 (0.6); 2.2867 (0.6); 2.2733 (0.7); 2.2628 (0.8); 2.2493 (0.8); 2.1643 (1.2); 2.1435 (1.3); 2.1295 (1.1); 2.1086 (1.2); 2.1026 (0.5); 2.0950 (0.7); 2.0710 (0.5); 1.7451 (0.5); 1.0207 (16.0); 1.0042 (15.9); -0.0002 (11.0) I.1-286:1H NMR (400.0MHz, d6-DMSO): δ= 7.3796 (0.9); 7.3589 (2.2); 7.3373 (2.2); 7.3163 (1.1); 7.2081 (1.1); 7.1992 (1.0); 7.1918 (2.0); 7.1883 (2.2); 7.1759 (2.2); 7.1718 (1.7); 7.1679 (1.6); 7.1555 (1.2); 7.0969 (1.2); 7.0810 (2.2); 7.0612 (1.6); 7.0452 (0.7); 5.0694 (1.0); 5.0605 (1.9); 5.0476 (1.1); 4.7892 (1.5); 4.7757 (1.2); 4.7526 (3.0); 4.7392 (1.2); 4.7151 (2.0); 4.3019 (0.7); 4.2884 (1.6); 4.2643 (2.0); 4.2487 (1.4); 4.2375 (1.0); 4.2240 (1.7); 4.1958 (0.9); 4.1811 (0.7); 4.1674 (1.5); 4.1500 (2.2); 4.1354 (1.5); 4.1327 (2.0); 4.1301 (2.4); 4.1230 (2.0); 4.1177 (1.6); 4.1123 (4.3); 4.1099 (3.6); 4.1052 (5.6); 4.0945 (3.7); 4.0921 (3.4); 4.0874 (5.6); 4.0766 (1.2); 4.0697 (1.8); 3.8576 (0.9); 3.8485 (1.0); 3.8383 (0.9); 3.8264 (0.9); 3.8153 (0.9); 3.8046 (0.9); 3.7932 (0.9); 3.7838 (1.2); 3.7744 (1.0); 3.7392 (1.0); 3.7061 (0.6); 3.3521 (0.9); 3.3172 (207.4); 3.2934 (5.9); 3.0627 (0.5); 3.0443 (0.6); 3.0371 (0.8); 3.0305 (0.8); 3.0197 (0.9); 3.0124 (0.9); 2.9876 (0.6); 2.9416 (6.9); 2.8973 (1.1); 2.8866 (0.9); 2.8652 (0.6); 2.8568 (1.4); 2.8461 (1.1); 2.8392 (0.9); 2.8289 (0.9); 2.7991 (1.1); 2.7894 (1.0); 2.6748 (0.8); 2.6701 (1.2); 2.6655 (0.9); 2.5986 (1.2); 2.5908 (1.5); 2.5766 (1.8); 2.5588 (1.2); 2.5451 (0.8); 2.5404 (1.4); 2.5361 (1.3); 2.5236 (2.0); 2.5189 (3.7); 2.5102 (68.7); 2.5056 (152.9); 2.5010 (215.3); 2.4964 (151.0); 2.4918 (68.4); 2.4813 (3.5); 2.4730 (2.5); 2.4684 (2.0); 2.4633 (1.6); 2.4509 (0.7); 2.4409 (1.8); 2.4314 (1.4); 2.4183 (1.3); 2.4001 (2.0); 2.3778 (1.2); 2.3572 (0.8); 2.3374 (1.0); 2.3325 (1.3); 2.3278 (1.5); 2.3231 (1.3); 2.3188 (1.1); 2.3012 (0.7); 2.2777 (1.3); 2.2696 (0.9); 2.2652 (1.1); 2.2574 (1.0); 2.2533 (1.7); 2.2450 (1.4); 2.2412 (1.8); 2.2333 (1.3); 2.2119 (1.6); 2.2046 (1.9); 2.1925 (1.5); 2.1798 (0.8); 2.1708 (1.4); 2.1606 (1.4); 2.1471 (1.5); 2.1402 (1.6); 2.1158 (1.4); 2.0963 (1.5); 2.0734 (1.0); 2.0620 (1.3); 1.7125 (0.6); 1.7002 (0.6); 1.6875 (1.1); 1.6820 (1.0); 1.6576 (1.7); 1.6468 (2.1); 1.6148 (2.6); 1.6051 (2.5); 1.5825 (1.9); 1.5442 (0.8); 1.5292 (0.9); 1.5100 (1.1); 1.5010 (0.8); 1.4936 (0.8); 1.4776 (0.7); 1.4685 (0.5); 1.3801 (0.5); 1.3479 (0.6); 1.2847 (0.5); 1.2518 (0.9); 1.2432 (1.4); 1.2254 (2.3); 1.2148 (4.8); 1.2076 (1.8); 1.1970 (9.6); 1.1944 (8.8); 1.1889 (4.5); 1.1821 (8.5); 1.1793 (6.2); 1.1766 (16.0); 1.1712 (7.7); 1.1644 (15.5); 1.1588 (7.6); 1.1534 (3.7); 1.1466 (6.8); -0.0002 (2.2) I.1-287:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1873 (0.5); 7.1808 (2.0); 7.1728 (7.6); 7.1681 (4.3); 7.1632 (1.2); 7.1559 (1.7); 7.1506 (0.7); 7.1436 (1.2); 7.1094 (1.5); 7.0968 (1.2); 7.0909 (0.6); 4.7105 (1.7); 4.6711 (2.0); 4.0769 (1.8); 4.0375 (1.6); 3.9636 (1.1); 3.6728 (0.7); 3.6629 (0.7); 3.6590 (0.6); 3.6528 (0.8); 3.6496 (0.9); 3.6437 (0.6); 3.6394 (0.8); 3.6297 (0.8); 3.5374 (1.7); 3.5051 (1.3); 3.1673 (9.4); 2.6773 (1.2); 2.6681 (1.3); 2.6377 (1.5); 2.6284 (1.5); 2.5233 (0.5); 2.5186 (0.8); 2.5100 (11.6); 2.5054 (25.4); 2.5008 (35.5); 2.4962 (24.9); 2.4916 (11.3); 2.4555 (0.6); 2.4514 (0.7); 2.4318 (0.9); 2.4113 (0.9); 2.3898 (0.6); 2.3573 (1.7); 2.3339 (1.7); 2.3178 (1.5); 2.3049 (0.7); 2.2941 (1.9); 2.2803 (1.1); 2.2687 (1.0); 2.2387 (0.8); 2.2242 (16.0); 2.2087 (0.6); 2.1895 (0.8); 2.1777 (0.6); 2.1650 (0.5); 2.1579 (0.8); 2.1334 (0.6); 1.7506 (0.6); 1.7289 (0.7); 1.7194 (0.7); -0.0002 (8.4) I.1-288:1H NMR (400.0MHz, d6-DMSO): δ= 12.4475 (0.8); 8.1332 (1.0); 8.1120 (1.3); 8.0881 (0.9); 7.2016 (1.9); 7.1811 (3.9); 7.1444 (3.4); 7.1241 (1.7); 4.6852 (1.0); 4.6455 (1.1); 4.3392 (0.6); 4.3224 (0.6); 4.1931 (0.6); 3.9904 (1.2); 3.9516 (1.0); 3.6687 (0.5); 3.3215 (161.4); 3.1672 (7.5); 2.8755 (0.7); 2.8584 (1.0); 2.8416 (0.8); 2.6789 (1.3); 2.6743 (3.0); 2.6697 (4.2); 2.6651 (2.8); 2.6604 (1.2); 2.5232 (12.6); 2.5184 (18.3); 2.5098 (240.9); 2.5052 (517.3); 2.5006 (719.5); 2.4960 (504.1); 2.4914 (224.8); 2.4655 (0.7); 2.4499 (1.4); 2.4454 (1.4); 2.3367 (1.8); 2.3319 (3.3); 2.3274 (4.6); 2.3227 (3.8); 2.2996 (0.7); 2.2370 (0.7); 2.2235 (0.7); 2.1886 (0.9); 2.1640 (0.7); 2.1545 (0.7); 2.1305 (0.6); 2.0731 (4.5); 1.9650 (0.6); 1.7248 (0.5); 1.5995 (0.8); 1.5825 (0.8); 1.5650 (0.9); 1.5311 (0.7); 1.5017 (0.9); 1.4885 (0.9); 1.4658 (0.8); 1.4320 (1.3); 1.4141 (1.4); 1.1936 (16.0); 1.1763 (15.8); 0.8866 (5.4); 0.8798 (5.2); 0.8704 (5.8); 0.8632 (5.7); 0.8467 (1.3); 0.8333 (4.8); 0.8173 (8.7); 0.8015 (4.7); 0.7796 (1.0); 0.1460 (0.8); 0.0080 (7.6); -0.0002 (278.8); -0.0085 (8.7); -0.1497 (1.0) I.1-290:1H NMR (400.0MHz, d6-DMSO): δ= 7.4076 (1.4); 7.4012 (11.5); 7.3965 (4.0); 7.3850 (4.6); 7.3801 (16.0); 7.3739 (2.1); 7.2602 (12.3); 7.2390 (9.2); 7.2038 (3.0); 7.0722 (6.5); 6.9405 (3.3); 4.6044 (4.3); 4.5654 (5.0); 4.1446 (5.0); 4.1056 (4.4); 3.8098 (1.1); 3.7993 (1.8); 3.7887 (2.4); 3.7782 (2.7); 3.7682 (2.5); 3.7577 (2.0); 3.7474 (1.2); 3.7311 (0.6); 3.7202 (0.6); 3.6832 (0.5); 3.5964 (0.7); 3.5503 (2.5); 3.1697 (0.5); 2.8085 (2.6); 2.7981 (2.7); 2.7689 (3.3); 2.7586 (3.2); 2.5240 (0.5); 2.5192 (0.9); 2.5106 (19.6); 2.5061 (42.3); 2.5015 (58.4); 2.4969 (42.5); 2.4923 (20.8); 2.4670 (0.7); 2.4529 (3.8); 2.4474 (1.3); 2.4426 (1.4); 2.4309 (3.3); 2.4239 (1.7); 2.4136 (3.1); 2.4001 (2.6); 2.3914 (2.8); 2.3818 (2.4); 2.3771 (2.1); 2.3585 (1.9); 2.3281 (0.5); 2.3008 (1.6); 2.2875 (2.0); 2.2765 (2.5); 2.2632 (2.6); 2.2461 (0.9); 2.2346 (1.5); 2.2219 (1.6); 2.1901 (1.0); 2.1712 (1.6); 2.1664 (1.0); 2.1587 (1.3); 2.1523 (1.2); 2.1469 (1.4); 2.1398 (1.9); 2.1347 (1.2); 2.1282 (0.9); 2.1204 (1.2); 2.1153 (1.4); 2.0962 (0.7); 1.7316 (0.8); 1.7197 (1.3); 1.7084 (1.7); 1.6978 (1.6); 1.6880 (1.6); 1.6766 (1.6); 1.6652 (1.1); 1.6525 (0.7); -0.0002 (18.5); -0.0085 (0.8) I.1-291:1H NMR (400.1 MHz, CDCl3): δ= 7.2620 (21.2); 7.2599 (23.3); 7.1516 (0.6); 7.1301 (2.8); 7.1098 (6.7); 7.0917 (2.5); 7.0840 (6.6); 7.0640 (2.6); 5.2993 (2.5); 5.2973 (2.7); 4.8264 (2.0); 4.7888 (2.2); 4.6068 (0.3); 4.0072 (2.2); 3.9694 (2.1); 3.9557 (0.7); 3.9460 (1.1); 3.9360 (1.2); 3.9259 (1.1); 3.9161 (0.7); 3.9060 (0.4); 3.2797 (0.4); 3.2626 (0.3); 2.8558 (0.6); 2.8306 (0.6); 2.8164 (2.0); 2.7968 (1.2); 2.7856 (1.2); 2.7567 (1.5); 2.7458 (1.5); 2.5760 (1.8); 2.5564 (2.1); 2.5353 (2.0); 2.5154 (1.9); 2.4901 (0.9); 2.4784 (0.9); 2.4667 (1.1); 2.4542 (1.2); 2.4421 (1.2); 2.4234 (0.4); 2.4107 (0.6); 2.3988 (0.5); 2.3339 (1.2); 2.3176 (16.0); 2.2898 (0.6); 2.2680 (0.8); 2.2564 (0.6); 2.2454 (0.8); 2.2353 (0.9); 2.2245 (0.4); 2.2121 (0.8); 1.8761 (0.4); 1.8654 (0.7); 1.8539 (0.7); 1.8426 (0.9); 1.8322 (0.9); 1.8212 (0.6); 1.8095 (0.6); 1.7988 (0.4); 1.2594 (0.3); 1.1924 (0.5); 1.1730 (0.9); 1.1553 (0.4); 0.0020 (5.5) I.1-292:1H NMR (400.0MHz, d6-DMSO): δ= 7.8237 (3.9); 7.3694 (0.8); 7.3653 (0.8); 7.3494 (0.6); 7.3435 (0.8); 7.1987 (0.8); 7.1952 (0.9); 7.1862 (0.8); 7.1829 (0.9); 7.1787 (0.6); 7.1749 (0.6); 7.1069 (0.7); 7.0906 (1.0); 7.0716 (0.6); 4.7754 (1.1); 4.7358 (1.3); 4.2921 (1.6); 4.2524 (1.5); 4.0350 (0.7); 3.9146 (0.6); 3.9045 (0.9); 3.8936 (1.1); 3.8843 (1.2); 3.8731 (1.0); 3.8630 (0.8); 3.5986 (16.0); 3.1667 (0.7); 2.8870 (0.6); 2.8770 (0.6); 2.8495 (0.7); 2.8398 (0.7); 2.7718 (0.5); 2.5541 (0.8); 2.5310 (1.0); 2.5236 (1.6); 2.5188 (2.6); 2.5102 (27.6); 2.5057 (58.6); 2.5011 (81.0); 2.4965 (57.0); 2.4919 (25.9); 2.4689 (0.6); 2.4270 (1.0); 2.4082 (0.9); 2.4043 (0.8); 2.3867 (0.6); 2.3279 (1.1); 2.3151 (0.7); 2.3035 (1.0); 2.2909 (1.0); 2.2618 (0.7); 2.2515 (1.1); 2.2347 (0.7); 2.2227 (0.6); 2.2038 (0.8); 2.1793 (0.5); 1.8635 (0.5); 1.8521 (0.6); 1.8414 (0.6); 1.8340 (0.6); 0.0080 (1.1); -0.0002 (35.3); -0.0085 (1.0) I.1-293:1H NMR (400.0MHz, d6-DMSO): δ= 12.4987 (1.2); 8.2519 (1.7); 8.2321 (1.6); 7.2274 (1.6); 7.2231 (2.1); 7.2129 (4.3); 7.2094 (6.0); 7.1972 (0.8); 7.1738 (1.0); 7.1677 (0.9); 7.1550 (2.0); 7.1479 (2.0); 7.1411 (1.3); 7.1268 (2.7); 7.1091 (0.9); 4.7638 (2.3); 4.7248 (2.5); 4.1909 (0.6); 4.1707 (1.0); 4.1548 (1.1); 4.1333 (0.7); 4.0633 (2.1); 4.0242 (1.9); 3.6789 (0.6); 3.6562 (1.0); 3.6338 (0.6); 3.3120 (147.6); 2.6790 (0.7); 2.6744 (1.4); 2.6697 (2.0); 2.6651 (1.5); 2.6605 (0.6); 2.6292 (1.0); 2.6104 (2.8); 2.6062 (2.7); 2.5916 (2.7); 2.5877 (2.8); 2.5717 (2.1); 2.5616 (1.4); 2.5489 (0.8); 2.5399 (2.5); 2.5378 (2.4); 2.5233 (6.1); 2.5185 (8.6); 2.5098 (112.3); 2.5053 (243.0); 2.5006 (338.8); 2.4960 (236.7); 2.4914 (104.2); 2.4700 (0.7); 2.4504 (0.6); 2.4458 (0.6); 2.4376 (0.7); 2.4145 (1.0); 2.3955 (0.9); 2.3732 (1.4); 2.3509 (0.8); 2.3369 (0.7); 2.3321 (1.4); 2.3274 (2.0); 2.3228 (1.4); 2.3181 (0.7); 2.2897 (0.8); 2.2796 (1.0); 2.2655 (1.2); 2.2553 (1.1); 2.2480 (0.8); 2.2383 (1.9); 2.2237 (0.7); 2.2148 (1.9); 2.2045 (1.4); 2.1808 (1.2); 2.0731 (0.6); 2.0430 (0.7); 2.0316 (0.6); 2.0203 (0.7); 2.0094 (0.9); 1.9888 (0.8); 1.8419 (0.6); 1.8329 (0.5); 1.8195 (0.9); 1.8097 (0.9); 1.6112 (0.6); 1.5952 (0.8); 1.5795 (0.7); 1.5058 (1.5); 1.4987 (1.6); 1.4929 (1.3); 1.4833 (2.7); 1.4693 (1.2); 1.4621 (1.2); 1.1437 (6.9); 1.1250 (16.0); 1.1061 (6.6); 0.8940 (9.8); 0.8776 (9.5); 0.8266 (9.9); 0.8104 (9.7); 0.1459 (0.5); 0.0118 (0.5); 0.0080 (5.2); 0.0063 (1.5); 0.0055 (1.8); 0.0047 (2.1); -0.0002 (181.9); -0.0051 (2.5); -0.0060 (1.9); -0.0068 (1.7); -0.0085 (5.3); -0.0107 (1.0); -0.0115 (0.8); -0.0140 (0.5); -0.1497 (0.6) I.1-294:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.3499 (1.7); 8.3286 (1.7); 7.2815 (1.7); 7.2634 (4.1); 7.2607 (3.0); 7.2509 (1.5); 7.2457 (4.9); 7.2175 (6.6); 7.2003 (3.8); 7.1866 (2.4); 7.1691 (0.9); 7.1272 (3.2); 7.1072 (7.0); 7.0806 (7.1); 7.0600 (3.1); 7.0365 (0.5); 4.6001 (1.9); 4.5618 (2.3); 4.4842 (0.6); 4.4731 (0.8); 4.4594 (1.1); 4.4517 (0.9); 4.4383 (0.8); 4.4276 (0.8); 3.9908 (2.2); 3.9529 (1.9); 3.5914 (1.0); 3.5805 (1.0); 3.3813 (10.8); 3.1637 (1.8); 3.0918 (1.1); 3.0791 (1.2); 3.0563 (1.4); 3.0453 (1.3); 2.8284 (1.4); 2.8027 (1.5); 2.7936 (1.2); 2.7679 (1.0); 2.6744 (1.2); 2.6697 (1.6); 2.6651 (1.2); 2.5378 (1.3); 2.5333 (2.5); 2.5232 (5.3); 2.5185 (6.9); 2.5098 (94.1); 2.5052 (204.3); 2.5006 (283.4); 2.4960 (195.9); 2.4914 (86.0); 2.4658 (0.8); 2.4563 (1.7); 2.4443 (1.7); 2.3320 (1.2); 2.3274 (1.5); 2.3227 (1.1); 2.2670 (16.0); 2.2497 (1.2); 2.2304 (1.2); 2.2072 (0.9); 2.1834 (1.1); 2.1701 (1.2); 2.1595 (1.3); 2.1455 (1.2); 2.1284 (0.7); 2.1177 (0.7); 2.0931 (1.6); 2.0699 (1.4); 2.0585 (1.3); 2.0361 (1.2); 1.7645 (0.7); 1.7403 (0.8); 1.7322 (0.9); 1.7085 (0.8); 1.3834 (0.8); 1.3738 (0.7); 1.3506 (0.6); 0.0328 (0.6); 0.0080 (2.8); 0.0055 (1.2); 0.0047 (1.3); 0.0023 (4.2); - 0.0002 (91.0); -0.0027 (4.6); -0.0052 (1.0); -0.0068 (0.7); -0.0085 (2.4) I.1-295:1H NMR (400.0MHz, d6-DMSO): δ= 11.8188 (0.8); 7.1858 (5.3); 7.1754 (8.0); 7.1478 (1.2); 7.0934 (1.2); 7.0862 (0.9); 7.0722 (0.9); 4.7125 (1.1); 4.6892 (0.8); 4.6726 (1.0); 4.6494 (0.9); 4.0782 (1.2); 4.0550 (1.5); 4.0385 (1.4); 4.0151 (1.5); 3.8680 (2.2); 3.7796 (2.2); 3.7433 (2.0); 3.7328 (2.0); 3.6115 (1.0); 3.5938 (1.2); 3.5682 (1.1); 3.5501 (0.9); 3.4235 (0.5); 3.2303 (3.3); 3.1896 (10.3); 3.1783 (2.4); 3.1672 (2.2); 3.1479 (1.5); 3.1299 (1.3); 3.1086 (1.3); 3.0868 (1.1); 3.0423 (0.9); 3.0278 (1.7); 3.0034 (1.0); 2.9899 (0.8); 2.9558 (0.8); 2.7659 (6.0); 2.7539 (5.7); 2.7268 (0.7); 2.7164 (0.7); 2.6886 (0.9); 2.6786 (1.0); 2.6745 (1.3); 2.6699 (1.6); 2.6653 (1.1); 2.5233 (2.9); 2.5186 (4.7); 2.5099 (77.6); 2.5053 (170.7); 2.5007 (240.2); 2.4961 (170.6); 2.4916 (78.3); 2.4508 (1.4); 2.4461 (1.4); 2.4274 (1.5); 2.4050 (1.3); 2.3956 (1.1); 2.3894 (1.1); 2.3673 (0.9); 2.3321 (1.6); 2.3274 (2.2); 2.3231 (2.0); 2.3125 (1.4); 2.2994 (1.6); 2.2886 (1.4); 2.2474 (3.0); 2.2305 (16.0); 2.1951 (0.9); 2.1837 (0.8); 2.1710 (0.9); 2.1499 (0.6); 2.0731 (0.5); 1.8163 (0.7); 1.7968 (0.9); 1.7775 (0.8); 1.7607 (0.8); 1.7509 (0.7); 1.7372 (0.7); 1.7283 (0.6); 1.7065 (0.5); 1.1869 (1.4); 1.1756 (1.5); 1.1325 (0.7); 1.0641 (2.4); 1.0461 (5.3); 1.0281 (2.4); 0.0080 (1.2); -0.0002 (43.6); -0.0085 (1.4) I.1-296:1H NMR (400.0 MHz, CDCl3): δ= 7.5204 (1.0); 7.2615 (178.9); 7.2514 (2.9); 7.2467 (2.4); 7.2382 (1.8); 7.2328 (4.2); 7.2278 (3.5); 7.2130 (4.7); 7.2081 (3.1); 7.1994 (2.4); 7.1946 (3.0); 7.1900 (3.0); 7.1854 (2.8); 7.1710 (6.9); 7.1665 (6.2); 7.1522 (4.7); 7.1476 (3.8); 7.1180 (1.4); 7.1022 (7.5); 7.0995 (8.0); 7.0932 (5.0); 7.0837 (10.5); 7.0810 (11.6); 7.0677 (6.4); 7.0622 (5.3); 7.0490 (15.2); 7.0426 (11.4); 7.0384 (8.2); 7.0337 (16.0); 7.0254 (10.9); 7.0148 (1.5); 7.0062 (4.7); 6.9976 (1.3); 5.4657 (3.0); 4.8462 (6.0); 4.8429 (6.1); 4.8075 (6.8); 4.8041 (6.9); 4.2303 (8.8); 4.1916 (7.7); 3.9338 (1.4); 3.9230 (2.9); 3.9120 (3.7); 3.9016 (4.0); 3.8918 (3.6); 3.8809 (3.0); 3.8699 (1.4); 3.5661 (0.5); 3.5490 (1.3); 3.5326 (3.5); 3.5156 (8.7); 3.4996 (12.2); 3.4835 (9.0); 3.4671 (3.5); 3.4499 (1.4); 3.4337 (0.5); 2.8632 (8.2); 2.8462 (15.7); 2.8292 (7.4); 2.5900 (5.8); 2.5792 (5.8); 2.5539 (6.8); 2.5431 (6.7); 2.5146 (1.3); 2.4955 (1.7); 2.4910 (1.6); 2.4715 (4.6); 2.4524 (4.0); 2.4483 (4.0); 2.4292 (3.9); 2.4132 (4.1); 2.3986 (4.6); 2.3890 (5.5); 2.3746 (5.6); 2.3559 (1.6); 2.3460 (2.5); 2.3318 (2.5); 2.2578 (2.1); 2.2386 (3.4); 2.2340 (1.9); 2.2250 (2.5); 2.2196 (2.1); 2.2146 (2.8); 2.2060 (3.9); 2.2010 (2.3); 2.1957 (1.6); 2.1867 (2.2); 2.1818 (3.0); 2.1626 (1.4); 2.1191 (7.2); 2.0965 (7.1); 2.0831 (6.3); 2.0604 (6.2); 1.8139 (2.2); 1.7998 (2.7); 1.7893 (3.4); 1.7796 (3.3); 1.7662 (3.4); 1.7560 (3.2); 1.7460 (2.8); 1.7317 (2.7); 0.0078 (1.5); -0.0002 (46.8); -0.0084 (1.6) I.1-298:1H NMR (400.0MHz, d6-DMSO): δ= 7.3558 (0.8); 7.3347 (0.8); 7.1868 (0.8); 7.1740 (0.8); 7.1701 (0.7); 7.1663 (0.5); 7.0966 (0.6); 7.0806 (0.8); 4.7607 (0.9); 4.7213 (1.0); 4.7000 (0.5); 4.2677 (1.1); 4.2286 (1.0); 4.2047 (2.5); 4.1741 (0.5); 4.0381 (3.8); 4.0344 (3.7); 3.8308 (0.6); 3.8210 (0.7); 3.8112 (0.7); 3.8017 (0.6); 3.6734 (7.7); 3.6200 (16.0); 3.4115 (14.4); 3.1660 (1.4); 2.9682 (14.8); 2.8500 (0.6); 2.8396 (0.6); 2.8092 (0.9); 2.7991 (0.8); 2.7689 (5.6); 2.6743 (1.0); 2.6699 (1.2); 2.6652 (0.8); 2.5695 (1.0); 2.5554 (0.6); 2.5507 (0.8); 2.5469 (1.2); 2.5401 (0.8); 2.5286 (1.8); 2.5233 (3.2); 2.5186 (4.7); 2.5099 (61.2); 2.5053 (131.9); 2.5007 (182.5); 2.4961 (127.8); 2.4916 (57.4); 2.4327 (0.7); 2.4087 (0.8); 2.3961 (0.5); 2.3322 (0.9); 2.3275 (1.2); 2.3229 (0.8); 2.2562 (0.5); 2.2432 (0.8); 2.2316 (0.8); 2.2019 (0.6); 2.1948 (1.2); 2.1792 (0.6); 2.1479 (0.7); 0.0080 (2.4); -0.0002 (81.5); -0.0085 (2.4) I.1-299:1H NMR (400.1 MHz, d6-DMSO): δ= 7.6319 (0.3); 3.3264 (16.0); 2.7602 (3.9); 2.5096 (2.8); 2.5051 (6.0); 2.5005 (8.5); 2.4959 (6.2); 2.4913 (3.0) I.1-301:1H NMR (400.0MHz, CDCl3): δ= 7.2611 (68.1); 7.2065 (0.8); 7.2018 (0.7); 7.1855 (1.6); 7.1809 (0.6); 7.1692 (0.7); 7.1646 (1.0); 7.1483 (0.5); 7.1125 (25.7); 6.8810 (2.0); 6.8614 (2.6); 6.8413 (1.7); 5.3513 (0.6); 4.6990 (1.8); 4.6615 (2.1); 4.1199 (1.9); 4.0824 (1.6); 3.9310 (0.7); 3.9202 (0.8); 3.9098 (1.0); 3.9001 (0.8); 3.8893 (0.7); 3.4923 (0.8); 3.4757 (1.2); 3.4592 (1.1); 3.4222 (1.0); 3.4067 (1.1); 3.3899 (0.7); 2.8688 (1.2); 2.8545 (2.2); 2.8521 (2.2); 2.8380 (1.0); 2.8353 (1.0); 2.5024 (1.3); 2.4912 (1.5); 2.4724 (1.0); 2.4662 (1.5); 2.4548 (2.1); 2.4305 (0.7); 2.4127 (0.9); 2.3984 (1.0); 2.3884 (1.1); 2.3743 (1.2); 2.3456 (0.6); 2.3314 (0.7); 2.3213 (16.0); 2.1863 (0.7); 2.1730 (0.5); 2.1621 (0.7); 2.1537 (0.8); 2.1488 (0.5); 2.1342 (0.5); 2.1293 (0.7); 2.0619 (1.6); 2.0400 (1.6); 2.0257 (1.4); 2.0038 (1.4); 1.7392 (0.5); 1.7286 (0.7); 1.7188 (0.6); 1.7057 (0.6); 1.6954 (0.6); -0.0002 (18.6); -0.0085 (0.6) I.1-302:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0108 (1.0); 8.0010 (1.0); 7.2249 (1.5); 7.2213 (1.7); 7.2130 (2.7); 7.2099 (4.1); 7.2070 (6.2); 7.1946 (0.7); 7.1765 (1.1); 7.1697 (1.0); 7.1576 (1.6); 7.1503 (1.6); 7.1432 (0.9); 7.1359 (1.0); 7.1000 (2.3); 7.0819 (1.4); 4.7470 (2.1); 4.7078 (2.4); 4.0548 (2.1); 4.0155 (1.9); 3.7070 (0.6); 3.6971 (0.9); 3.6863 (1.1); 3.6757 (0.9); 3.6658 (0.5); 3.5009 (5.9); 2.6237 (0.9); 2.6046 (3.0); 2.5942 (1.0); 2.5859 (3.7); 2.5762 (1.5); 2.5665 (2.2); 2.5483 (0.9); 2.5457 (0.7); 2.5402 (0.7); 2.5234 (1.0); 2.5187 (1.5); 2.5100 (23.2); 2.5055 (50.9); 2.5008 (71.4); 2.4962 (49.7); 2.4916 (22.1); 2.4379 (1.3); 2.4269 (1.3); 2.4029 (1.6); 2.3916 (1.9); 2.3685 (0.9); 2.3473 (1.4); 2.3243 (0.9); 2.2847 (0.8); 2.2734 (1.0); 2.2603 (1.2); 2.2493 (1.2); 2.2426 (0.6); 2.2316 (0.6); 2.2183 (0.6); 2.2074 (0.6); 2.1282 (1.7); 2.1060 (1.8); 2.0932 (1.5); 2.0819 (0.8); 2.0710 (1.9); 2.0584 (0.7); 2.0498 (0.9); 2.0264 (0.7); 1.7374 (0.6); 1.7285 (0.5); 1.7247 (0.5); 1.7158 (0.9); 1.7052 (0.9); 1.1446 (6.8); 1.1259 (16.0); 1.1070 (6.7); 0.6058 (0.9); 0.5936 (2.7); 0.5883 (3.6); 0.5759 (3.4); 0.5704 (3.0); 0.5584 (1.2); 0.3497 (1.3); 0.3397 (3.2); 0.3334 (2.8); 0.3284 (2.7); 0.3234 (2.8); 0.3115 (1.1); -0.0002 (5.5) I.1-303:1H NMR (400.0MHz, d6-DMSO): δ= 11.8166 (10.6); 8.0474 (2.6); 7.3838 (2.8); 7.3668 (5.4); 7.3424 (5.8); 7.3215 (3.5); 7.2101 (3.3); 7.1938 (5.9); 7.1782 (5.8); 7.1616 (3.6); 7.0731 (5.9); 7.0571 (7.6); 7.0409 (5.2); 7.0210 (2.4); 4.7204 (8.1); 4.6804 (9.2); 4.2464 (9.6); 4.2071 (8.5); 3.8462 (3.6); 3.8357 (4.9); 3.8259 (5.5); 3.8153 (4.6); 3.4014 (5.1); 3.3446 (566.1); 3.2334 (18.4); 3.2120 (111.6); 3.1658 (16.0); 2.7482 (7.1); 2.7376 (6.2); 2.7098 (7.4); 2.6993 (7.2); 2.6744 (15.0); 2.6698 (20.9); 2.6651 (14.7); 2.5623 (7.1); 2.5573 (5.4); 2.5232 (52.8); 2.5185 (81.7); 2.5098 (1173.9); 2.5053 (2552.9); 2.5007 (3561.7); 2.4961 (2494.2); 2.4915 (1123.6); 2.4606 (20.4); 2.4561 (23.2); 2.4514 (20.1); 2.4467 (9.1); 2.4375 (5.1); 2.4156 (10.0); 2.3988 (13.9); 2.3777 (12.1); 2.3564 (6.2); 2.3368 (8.4); 2.3322 (16.6); 2.3274 (22.3); 2.3229 (16.4); 2.3184 (8.5); 2.3038 (6.0); 2.2920 (5.8); 2.2800 (7.4); 2.2676 (7.2); 2.2381 (4.8); 2.2236 (5.9); 2.2047 (6.5); 2.1934 (4.4); 2.1741 (5.6); 2.1503 (4.3); 2.0732 (6.3); 1.7786 (3.5); 1.7677 (3.7); 1.7488 (4.5); 1.7241 (2.8); 1.1327 (2.5); 0.1461 (5.4); 0.0080 (44.0); -0.0002 (1593.3); -0.0086 (48.3); -0.0496 (8.1); -0.1495 (5.3) I.1-304:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.3794 (0.9); 7.3592 (1.9); 7.3374 (2.0); 7.3160 (0.9); 7.2080 (1.0); 7.1881 (2.0); 7.1756 (1.9); 7.1557 (1.0); 7.0970 (1.2); 7.0810 (1.8); 7.0623 (1.4); 5.0609 (1.7); 4.7885 (1.4); 4.7758 (1.1); 4.7522 (2.6); 4.7150 (1.7); 4.2886 (1.4); 4.2643 (1.8); 4.2493 (1.2); 4.2381 (0.8); 4.2230 (1.5); 4.1983 (0.7); 4.1804 (0.7); 4.1671 (1.3); 4.1498 (1.8); 4.1302 (2.2); 4.1228 (1.7); 4.1122 (3.7); 4.1050 (4.8); 4.0945 (3.2); 4.0873 (4.6); 4.0764 (1.0); 4.0694 (1.4); 3.8482 (1.0); 3.8147 (0.8); 3.7834 (1.1); 3.7395 (1.0); 3.7053 (0.6); 3.4581 (16.0); 3.1667 (1.2); 3.0383 (0.8); 3.0128 (0.8); 2.8972 (1.1); 2.8862 (0.8); 2.8567 (1.3); 2.8465 (1.0); 2.8293 (0.8); 2.7991 (1.0); 2.7893 (1.0); 2.6745 (1.0); 2.6700 (1.4); 2.6655 (0.9); 2.5981 (1.2); 2.5913 (1.4); 2.5760 (1.5); 2.5590 (0.6); 2.5368 (2.0); 2.5235 (4.2); 2.5188 (6.2); 2.5101 (83.2); 2.5056 (178.8); 2.5010 (248.2); 2.4963 (172.2); 2.4918 (75.6); 2.4622 (0.9); 2.4403 (1.3); 2.4001 (1.6); 2.3780 (1.0); 2.3324 (1.3); 2.3278 (1.6); 2.3231 (1.2); 2.3015 (0.5); 2.2781 (1.0); 2.2648 (1.0); 2.2531 (1.4); 2.2410 (1.4); 2.2043 (1.7); 2.1921 (1.4); 2.1708 (1.2); 2.1402 (1.3); 2.1158 (1.1); 2.0962 (1.2); 2.0608 (1.1); 1.6470 (1.9); 1.6141 (2.2); 1.5103 (0.8); 1.3485 (0.5); 1.2147 (4.0); 1.1970 (7.8); 1.1943 (7.2); 1.1888 (3.8); 1.1820 (6.9); 1.1765 (12.8); 1.1711 (6.1); 1.1643 (11.9); 1.1588 (5.9); 1.1534 (2.9); 1.1466 (5.2); 0.0080 (1.4); -0.0002 (47.2); -0.0086 (1.2) I.1-305:1H NMR (400.0 MHz, i.e6-DMSO): δ= 10.4725 (1.2); 8.1108 (0.9); 8.1085 (1.0); 8.0899 (1.0); 8.0876 (1.0); 7.8869 (1.0); 7.8834 (1.1); 7.8670 (1.1); 7.8635 (1.1); 7.6090 (0.6); 7.6048 (0.6); 7.5905 (0.7); 7.5868 (0.8); 7.5842 (0.6); 7.5698 (0.6); 7.5657 (0.6); 7.2211 (0.8); 7.2181 (0.8); 7.2026 (1.0); 7.2013 (1.0); 7.1997 (1.0); 7.1985 (1.0); 7.1830 (0.8); 7.1800 (0.7); 7.1015 (7.5); 4.6827 (0.9); 4.6446 (1.0); 4.1027 (1.0); 4.0647 (0.9); 3.8249 (16.0); 3.8111 (0.5); 3.6473 (1.5); 2.8263 (0.6); 2.8150 (0.6); 2.7893 (0.8); 2.7780 (0.7); 2.5236 (0.6); 2.5189 (1.0); 2.5102 (14.4); 2.5056 (31.1); 2.5010 (43.5); 2.4964 (30.6); 2.4918 (14.3); 2.4767 (0.9); 2.4556 (0.7); 2.4254 (0.5); 2.2801 (0.6); 2.2667 (0.6); 2.2496 (8.1); 2.0732 (0.6); -0.0002 (5.1) I.1-306:1H NMR (400.0MHz, d6-DMSO): δ= 9.9796 (1.2); 7.5544 (1.5); 7.5515 (1.9); 7.5468 (0.6); 7.5327 (2.1); 7.5301 (1.9); 7.3081 (1.7); 7.3032 (0.6); 7.2895 (2.2); 7.2871 (1.9); 7.2728 (0.6); 7.2683 (1.7); 7.1246 (16.0); 7.0552 (0.8); 7.0368 (1.3); 7.0183 (0.6); 4.6938 (1.0); 4.6558 (1.1); 4.0696 (1.1); 4.0316 (1.0); 3.8135 (0.6); 3.3228 (17.6); 2.7593 (0.7); 2.7482 (0.7); 2.7233 (0.9); 2.7122 (0.8); 2.5102 (6.6); 2.5056 (14.3); 2.5010 (20.0); 2.4963 (14.0); 2.4917 (6.2); 2.3892 (1.0); 2.3728 (0.6); 2.3671 (1.1); 2.3527 (0.9); 2.3309 (0.7); 2.2918 (0.6); 2.2811 (1.0); 2.2731 (9.7); 2.0730 (0.9); -0.0002 (2.5) I.1-307:1H NMR (400.0MHz, d6-DMSO): δ= 8.2756 (1.9); 8.2707 (1.9); 8.2395 (0.6); 8.2338 (0.6); 7.6813 (1.2); 7.6750 (1.2); 7.6607 (1.5); 7.6545 (1.5); 7.5234 (0.8); 7.5038 (0.6); 7.4882 (2.4); 7.4869 (2.4); 7.4678 (2.0); 7.4664 (2.0); 7.1415 (1.2); 7.1212 (5.0); 7.1093 (5.6); 7.0886 (1.3); 7.0765 (1.2); 7.0414 (1.3); 7.0215 (0.6); 4.6772 (1.2); 4.6390 (1.7); 4.5249 (0.9); 4.5167 (0.8); 4.5074 (0.8); 4.4873 (2.3); 4.4519 (2.3); 4.4140 (0.8); 4.0595 (1.4); 4.0219 (1.6); 3.7925 (0.6); 3.7800 (0.7); 3.7701 (0.6); 3.7602 (0.6); 3.5480 (2.4); 2.8634 (16.0); 2.8351 (0.8); 2.8254 (0.8); 2.7940 (1.0); 2.7847 (0.9); 2.7549 (4.1); 2.5238 (1.0); 2.5191 (1.6); 2.5104 (22.7); 2.5058 (49.6); 2.5012 (69.8); 2.4966 (48.8); 2.4920 (22.6); 2.4744 (1.0); 2.4513 (1.1); 2.4294 (0.6); 2.4121 (0.7); 2.3939 (0.6); 2.3704 (0.6); 2.3282 (0.5); 2.2740 (10.3); 2.2594 (3.3); 2.2411 (1.0); 2.2285 (0.8); 2.1995 (0.5); 2.1876 (0.6); 2.1350 (0.6); 2.1229 (0.5); 2.1154 (0.6); 2.1037 (0.7); 1.6496 (0.5); 1.6416 (0.6); 1.6306 (0.5); 0.0080 (1.0); -0.0002 (33.4); -0.0085 (1.0) I.1-308:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.9138 (2.4); 8.8925 (2.4); 7.3672 (0.6); 7.3634 (0.7); 7.3441 (4.2); 7.3408 (4.6); 7.3370 (2.2); 7.3280 (5.4); 7.3254 (7.4); 7.3225 (8.7); 7.3199 (7.9); 7.3063 (6.4); 7.3041 (7.4); 7.2603 (3.8); 7.2533 (16.0); 7.2451 (5.4); 7.2348 (9.3); 7.2312 (7.2); 7.2263 (2.0); 7.2221 (1.2); 7.2180 (1.2); 7.2146 (0.6); 7.1875 (0.7); 7.1838 (0.8); 7.1749 (0.7); 7.1711 (0.9); 7.1676 (1.3); 7.1641 (1.4); 7.1548 (1.3); 7.1516 (1.4); 7.1476 (0.9); 7.1435 (0.9); 7.1346 (0.8); 7.1312 (0.8); 7.0655 (1.4); 7.0495 (1.9); 7.0301 (1.0); 6.1065 (3.0); 6.0853 (2.9); 4.7258 (2.1); 4.6859 (2.4); 4.2210 (2.6); 4.1813 (2.3); 3.8224 (0.8); 3.8119 (1.2); 3.8016 (1.5); 3.7917 (1.2); 3.7812 (0.9); 3.4995 (3.8); 3.1668 (1.2); 2.6716 (1.9); 2.6607 (1.9); 2.6369 (2.1); 2.6258 (1.9); 2.5232 (1.7); 2.5185 (2.5); 2.5099 (32.0); 2.5053 (69.1); 2.5007 (95.9); 2.4961 (67.1); 2.4915 (30.0); 2.3845 (2.3); 2.3627 (2.7); 2.3497 (1.8); 2.3391 (1.6); 2.3277 (2.4); 2.3187 (1.7); 2.2968 (1.2); 2.2678 (1.1); 2.2547 (1.3); 2.2438 (1.6); 2.2308 (1.6); 2.2130 (0.6); 2.2018 (0.8); 2.1891 (0.8); 2.1245 (0.6); 2.1049 (1.0); 2.0929 (0.8); 2.0854 (0.7); 2.0811 (0.9); 2.0732 (1.4); 2.0537 (0.7); 2.0494 (1.0); 1.7912 (0.5); 1.7789 (0.8); 1.7680 (1.1); 1.7579 (1.0); 1.7465 (1.0); 1.7364 (1.0); 1.7254 (0.6); 0.0080 (1.2); -0.0002 (40.1); -0.0086 (1.1) I.1-309:1H NMR (400.1 MHz, CDCl3): δ= 7.5185 (0.4); 7.2603 (76.8); 7.2598 (81.3); 7.2462 (0.4); 7.1586 (1.4); 7.1440 (1.3); 7.1378 (8.3); 7.1285 (8.4); 7.1076 (1.5); 6.9958 (0.4); 5.3280 (0.8); 4.6982 (0.3); 4.6600 (2.1); 4.6224 (2.4); 4.2056 (2.3); 4.1934 (0.3); 4.1680 (2.0); 4.1308 (0.5); 4.1130 (0.5); 3.9876 (0.4); 3.9764 (0.7); 3.9673 (0.9); 3.9562 (1.5); 3.9450 (0.9); 3.9360 (0.8); 3.9246 (0.4); 2.6555 (0.5); 2.6475 (0.9); 2.6381 (1.2); 2.6297 (1.3); 2.6206 (1.0); 2.6121 (0.6); 2.5317 (0.4); 2.5128 (0.5); 2.4894 (1.2); 2.4681 (2.4); 2.4561 (1.5); 2.4469 (1.1); 2.4319 (1.8); 2.4202 (2.2); 2.4100 (1.1); 2.3996 (1.4); 2.3859 (1.3); 2.3812 (0.8); 2.3674 (0.5); 2.3569 (0.9); 2.3431 (0.8); 2.3295 (16.0); 2.3186 (2.4); 2.2677 (0.6); 2.2482 (0.9); 2.2436 (0.5); 2.2352 (0.6); 2.2288 (0.5); 2.2242 (0.7); 2.2158 (1.0); 2.2111 (0.6); 2.2049 (0.4); 2.1961 (0.5); 2.1915 (0.8); 2.1719 (0.4); 2.0805 (1.8); 2.0601 (1.8); 2.0435 (3.3); 2.0240 (1.5); 1.8274 (0.4); 1.8143 (0.6); 1.8034 (0.8); 1.7937 (0.8); 1.7807 (0.8); 1.7706 (0.8); 1.7600 (0.6); 1.7467 (0.4); 1.5517 (10.0); 1.2764 (0.6); 1.2585 (1.3); 1.2411 (0.6); 0.7667 (1.0); 0.7584 (1.0); 0.7508 (2.8); 0.7365 (2.2); 0.7334 (2.4); 0.7279 (1.1); 0.7214 (1.1); 0.4283 (0.9); 0.4240 (1.1); 0.4175 (2.8); 0.4087 (2.7); 0.4040 (2.0); 0.3944 (0.8); 0.0083 (0.9); 0.0000 (35.8) I.1-310:1H NMR (400.1 MHz, i.e6-DMSO): δ= 12.2691 (1.0); 7.4362 (1.3); 7.4309 (1.4); 7.4221 (1.6); 7.4168 (1.5); 7.4112 (1.6); 7.4007 (6.2); 7.3952 (3.4); 7.3811 (6.4); 7.3742 (5.7); 7.3609 (3.1); 7.3549 (4.2); 7.3439 (1.8); 7.3338 (2.0); 7.1955 (1.6); 7.1903 (1.8); 7.1799 (3.1); 7.1745 (3.0); 7.1690 (3.0); 7.1638 (2.9); 7.1534 (1.5); 7.1480 (1.3); 5.0782 (0.8); 5.0605 (2.6); 5.0424 (2.7); 5.0249 (0.9); 5.0067 (0.8); 4.9887 (2.5); 4.9708 (2.6); 4.9530 (0.8); 4.0291 (0.5); 4.0203 (1.1); 4.0107 (1.3); 4.0049 (1.3); 4.0004 (1.6); 3.9970 (1.6); 3.9917 (1.3); 3.9869 (1.4); 3.9770 (1.3); 3.9679 (0.6); 3.7143 (0.6); 3.7056 (1.1); 3.6945 (1.1); 3.6898 (1.2); 3.6856 (1.5); 3.6815 (1.6); 3.6707 (1.2); 3.6618 (1.2); 3.6539 (0.6); 3.5507 (0.7); 3.4161 (0.4); 3.3841 (0.4); 3.3736 (0.4); 3.3191 (65.5); 3.2699 (1.2); 3.1688 (1.1); 2.6791 (0.4); 2.6747 (0.8); 2.6700 (1.1); 2.6655 (0.9); 2.6573 (2.3); 2.6485 (2.3); 2.6174 (3.1); 2.6085 (3.1); 2.5986 (0.8); 2.5940 (0.6); 2.5735 (0.4); 2.5235 (2.5); 2.5188 (3.7); 2.5100 (56.5); 2.5056 (123.5); 2.5010 (173.8); 2.4964 (128.1); 2.4919 (62.3); 2.4753 (3.6); 2.4520 (5.0); 2.4474 (2.8); 2.4308 (4.0); 2.4196 (4.7); 2.4110 (2.9); 2.3953 (3.8); 2.3797 (2.6); 2.3555 (2.6); 2.3371 (0.5); 2.3325 (0.9); 2.3279 (1.2); 2.3233 (0.9); 2.2678 (2.3); 2.2587 (2.4); 2.2276 (4.0); 2.2186 (4.1); 2.2108 (1.3); 2.2025 (2.0); 2.1971 (1.6); 2.1928 (2.1); 2.1858 (5.4); 2.1781 (5.0); 2.1684 (4.0); 2.1614 (2.9); 2.1528 (4.3); 2.1399 (5.2); 2.1307 (3.1); 2.1161 (4.8); 2.1001 (2.9); 2.0935 (1.1); 2.0890 (1.1); 2.0823 (1.8); 2.0763 (2.9); 2.0593 (1.2); 2.0377 (0.5); 1.7216 (0.9); 1.7121 (1.4); 1.7055 (2.4); 1.6973 (1.2); 1.6897 (2.7); 1.6839 (3.8); 1.6683 (1.8); 1.6603 (1.6); 1.6523 (1.8); 1.6426 (0.9); 1.5865 (16.0); 1.5684 (16.0); 1.5436 (14.8); 1.5256 (14.7) I.1-312:1H NMR (400.0MHz, d6-DMSO): δ= 7.1436 (2.3); 7.1242 (7.0); 7.1038 (5.4); 7.0830 (2.3); 3.3907 (1.1); 3.3314 (1260.6); 3.2803 (4.0); 3.1676 (4.2); 2.7554 (2.3); 2.6746 (3.3); 2.6700 (4.8); 2.6655 (3.4); 2.5235 (9.0); 2.5188 (14.0); 2.5102 (259.8); 2.5056 (572.3); 2.5010 (802.6); 2.4965 (566.1); 2.4919 (258.8); 2.4550 (3.3); 2.4499 (3.4); 2.4128 (2.4); 2.3325 (3.9); 2.3278 (5.7); 2.3232 (4.2); 2.2749 (16.0); 2.0728 (3.5); 1.8865 (2.1); 1.6493 (1.2); 1.0877 (1.2); 1.0692 (2.2); 1.0514 (1.4); -0.0002 (9.4) I.1-314:1H NMR (400.0MHz, d6-DMSO): δ= 10.6278 (0.8); 8.0424 (0.7); 7.2236 (1.9); 7.2226 (2.0); 7.2018 (2.1); 7.2007 (2.2); 7.1386 (1.1); 7.1185 (3.2); 7.0998 (3.6); 7.0794 (2.5); 7.0741 (1.5); 6.9990 (1.6); 6.9929 (1.6); 6.7205 (1.2); 6.7145 (1.1); 6.6988 (1.0); 6.6928 (1.0); 4.6611 (0.9); 4.6233 (1.0); 4.0014 (1.0); 3.9635 (0.9); 3.7458 (16.0); 3.4762 (7.2); 3.3174 (0.9); 3.3023 (1.0); 3.2841 (0.5); 2.7724 (0.9); 2.7542 (1.5); 2.7359 (0.8); 2.5188 (0.5); 2.5101 (9.0); 2.5055 (19.8); 2.5009 (27.4); 2.4963 (19.5); 2.4917 (8.4); 2.4727 (0.7); 2.4616 (0.7); 2.3265 (0.6); 2.2735 (7.2); 2.2362 (0.5); 2.2260 (0.6); 2.2122 (0.6); 2.1202 (0.7); 2.0976 (0.7); 2.0856 (0.6); 2.0727 (0.7); 2.0629 (0.6); -0.0002 (1.2) I.1-318:1H NMR (400.1 MHz, d6-DMSO): δ= 11.4836 (1.4); 7.2489 (0.3); 7.2321 (0.3); 7.1991 (0.4); 7.1792 (0.4); 7.1314 (4.1); 7.1202 (4.3); 4.6747 (1.0); 4.6373 (1.2); 4.6032 (0.4); 4.4149 (0.3); 4.3513 (0.3); 4.3082 (0.3); 4.2870 (0.4); 4.2644 (0.4); 4.2499 (0.4); 4.2284 (0.4); 4.2148 (0.4); 4.1761 (0.4); 4.1732 (0.4); 4.1404 (0.5); 4.1281 (0.4); 4.1103 (0.4); 4.0872 (0.5); 4.0828 (0.5); 4.0689 (0.5); 4.0539 (0.5); 4.0104 (1.4); 3.9748 (1.3); 3.9426 (0.6); 3.9256 (0.6); 3.9098 (0.6); 3.8889 (0.6); 3.8618 (0.6); 3.8241 (0.6); 3.7866 (0.7); 3.7538 (0.8); 3.7078 (1.5); 3.6998 (1.4); 3.6480 (0.9); 3.5854 (1.0); 3.5828 (1.0); 3.5663 (1.0); 3.5352 (1.1); 3.4436 (1.3); 3.3391 (18.2); 3.2785 (1.2); 3.2364 (0.9); 3.2182 (0.9); 3.1982 (0.8); 3.1902 (0.9); 3.1703 (0.9); 3.1399 (0.9); 3.1315 (0.9); 3.0964 (1.0); 3.0809 (1.1); 3.0708 (1.0); 3.0671 (1.0); 3.0547 (1.0); 3.0504 (1.0); 3.0119 (1.2); 2.9768 (1.2); 2.9718 (1.2); 2.9397 (1.4); 2.8992 (1.5); 2.8906 (1.5); 2.8650 (1.7); 2.7710 (16.0); 2.7032 (2.7); 2.6750 (3.0); 2.5785 (3.0); 2.4997 (46.7); 2.4063 (1.3); 2.3781 (1.5); 2.3578 (2.0); 2.3354 (2.0); 2.2779 (6.6); 2.2245 (0.7); 2.1373 (0.4); 2.1212 (0.7); 2.0937 (0.8); 2.0686 (0.7); 1.7201 (0.7); 1.7097 (0.8); 1.6700 (0.5); 0.0274 (0.5) I.1-319:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4865 (0.9); 8.4679 (1.5); 8.4490 (1.0); 7.2890 (0.8); 7.2703 (2.0); 7.2675 (1.9); 7.2530 (3.2); 7.2392 (0.6); 7.2327 (2.2); 7.2307 (2.3); 7.2142 (2.2); 7.2114 (2.3); 7.2006 (4.5); 7.1840 (2.3); 7.1713 (1.5); 7.1624 (4.6); 7.1581 (7.1); 7.1434 (1.3); 7.1320 (0.9); 7.1273 (0.8); 7.0623 (1.8); 7.0475 (1.4); 4.6617 (1.7); 4.6221 (1.9); 4.5089 (0.5); 4.4563 (0.6); 4.4479 (0.5); 4.4368 (0.5); 3.9971 (1.1); 3.9741 (1.1); 3.9585 (1.0); 3.9348 (1.0); 3.5991 (15.8); 3.5939 (16.0); 3.5716 (0.8); 3.5483 (0.7); 3.4108 (8.0); 3.0655 (0.5); 3.0520 (1.0); 3.0389 (0.6); 3.0311 (0.8); 3.0179 (1.4); 3.0047 (0.7); 2.8671 (1.1); 2.8429 (1.2); 2.8333 (0.9); 2.8092 (0.8); 2.6741 (0.6); 2.6695 (0.9); 2.6649 (0.6); 2.5229 (2.3); 2.5183 (3.6); 2.5096 (51.8); 2.5050 (112.3); 2.5004 (155.8); 2.4958 (109.0); 2.4912 (49.4); 2.4732 (1.4); 2.4682 (1.4); 2.4576 (1.2); 2.4495 (1.3); 2.4396 (0.9); 2.3319 (0.8); 2.3272 (1.0); 2.3227 (0.7); 2.3122 (0.8); 2.2914 (1.0); 2.2704 (1.5); 2.2482 (0.9); 2.2233 (0.8); 2.2051 (11.5); 2.2020 (12.2); 2.1699 (1.3); 2.1597 (1.1); 2.1432 (1.0); 2.1358 (0.9); 2.1087 (0.6); 2.0851 (1.1); 0.0080 (2.4); -0.0002 (80.7); -0.0086 (2.3) I.1-320:1H NMR (400.0MHz, d6-DMSO): δ= 8.5024 (0.6); 8.4876 (0.7); 8.4829 (0.7); 8.4684 (0.6); 7.2706 (1.0); 7.2683 (1.0); 7.2532 (1.5); 7.2375 (0.7); 7.2336 (0.8); 7.2203 (1.9); 7.2149 (1.8); 7.2064 (3.0); 7.1934 (3.2); 7.1742 (2.9); 7.1069 (1.8); 7.0949 (1.8); 7.0868 (1.2); 7.0746 (1.2); 4.6414 (0.6); 4.6272 (0.6); 4.6031 (0.7); 4.5893 (0.6); 3.9586 (0.6); 3.9204 (0.6); 3.8827 (0.6); 3.8447 (0.6); 3.6013 (16.0); 3.4826 (1.8); 3.0304 (0.6); 3.0182 (0.5); 2.8693 (1.0); 2.8566 (0.6); 2.8445 (0.7); 2.8389 (0.8); 2.8347 (0.9); 2.5310 (0.5); 2.5186 (1.1); 2.5097 (13.6); 2.5052 (29.1); 2.5006 (40.4); 2.4960 (28.9); 2.4914 (13.0); 2.4738 (0.6); 2.1868 (0.6); 2.1760 (0.6); 2.1626 (0.6); 2.1304 (0.9); 2.1202 (0.6); 2.0960 (0.6); 1.1912 (8.7); 1.1874 (9.0); 1.1739 (8.7); 1.1701 (8.8); -0.0002 (14.5) I.1-321:1H NMR (400.0MHz, d6-DMSO): δ= 9.7394 (0.5); 8.3515 (1.0); 7.1505 (2.5); 7.1299 (8.7); 7.1152 (11.1); 7.0945 (2.8); 4.7081 (0.9); 4.6707 (1.1); 4.6600 (2.0); 4.6217 (2.3); 4.3155 (0.8); 4.0303 (2.4); 4.0107 (1.1); 3.9921 (2.1); 3.9724 (1.0); 3.7278 (0.9); 3.7170 (1.1); 3.7073 (1.4); 3.6967 (1.2); 3.6857 (0.9); 3.1685 (0.9); 2.7695 (0.5); 2.7586 (0.5); 2.7316 (0.6); 2.7215 (0.6); 2.6700 (0.5); 2.6119 (27.4); 2.5646 (4.4); 2.5237 (1.2); 2.5190 (2.0); 2.5103 (35.9); 2.5057 (79.5); 2.5011 (111.6); 2.4965 (78.9); 2.4919 (36.1); 2.4654 (1.6); 2.4550 (1.8); 2.4305 (1.8); 2.4195 (1.7); 2.3993 (1.3); 2.3756 (1.9); 2.3650 (6.9); 2.3385 (2.0); 2.3277 (1.0); 2.3234 (1.0); 2.3154 (1.0); 2.2780 (16.0); 2.2608 (1.6); 2.2469 (1.4); 2.2274 (0.9); 2.2191 (0.8); 2.2054 (0.7); 2.0976 (0.6); 2.0879 (1.6); 2.0788 (1.0); 2.0731 (1.0); 2.0657 (2.2); 2.0531 (2.1); 2.0469 (1.3); 2.0301 (1.7); 1.7149 (0.6); 1.7045 (0.8); 1.6860 (0.8); 1.6726 (0.8); 1.6623 (0.7); -0.0002 (18.9); -0.0086 (0.6) I.1-322:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.9181 (1.7); 8.8964 (1.7); 7.3487 (1.8); 7.3424 (2.0); 7.3386 (1.4); 7.3280 (4.7); 7.3217 (4.1); 7.3120 (4.8); 7.3055 (4.1); 7.2645 (7.8); 7.2549 (8.1); 7.2467 (5.6); 7.2367 (5.3); 7.2281 (1.2); 7.2183 (0.8); 7.1463 (2.7); 7.1260 (6.3); 7.0943 (6.3); 7.0738 (2.8); 6.1132 (2.1); 6.0923 (2.0); 4.6655 (1.8); 4.6278 (2.0); 3.9849 (2.0); 3.9465 (1.7); 3.7375 (0.6); 3.7268 (0.8); 3.7161 (0.9); 3.7070 (0.9); 3.6959 (0.6); 3.3526 (1.0); 3.3183 (139.8); 3.1677 (0.8); 2.6742 (0.8); 2.6696 (1.1); 2.6651 (0.8); 2.6565 (1.2); 2.6451 (1.1); 2.6217 (1.3); 2.6104 (1.3); 2.5934 (1.2); 2.5739 (3.6); 2.5550 (4.0); 2.5355 (2.1); 2.5231 (1.8); 2.5184 (3.2); 2.5098 (61.4); 2.5052 (135.6); 2.5006 (189.8); 2.4960 (133.7); 2.4914 (60.6); 2.3531 (0.6); 2.3312 (2.2); 2.3228 (1.1); 2.3082 (2.0); 2.2952 (1.5); 2.2734 (1.2); 2.2602 (0.8); 2.2463 (1.0); 2.2358 (1.0); 2.2225 (1.0); 2.1941 (0.6); 2.0730 (0.8); 2.0326 (0.6); 2.0074 (0.6); 2.0004 (0.9); 1.9760 (0.7); 1.7313 (0.6); 1.7185 (0.7); 1.7077 (0.7); 1.6859 (0.6); 1.1728 (7.0); 1.1538 (16.0); 1.1348 (6.8); -0.0002 (15.8) I.1-323:1H NMR (400.0MHz, d6-DMSO): δ= 7.1791 (3.6); 7.1587 (10.4); 7.1375 (7.8); 7.1219 (3.0); 7.1173 (3.2); 7.0997 (1.9); 7.0790 (0.8); 5.0635 (1.3); 5.0563 (1.3); 5.0497 (1.3); 4.7506 (1.3); 4.7120 (2.2); 4.6985 (1.2); 4.6727 (0.8); 4.6601 (1.6); 4.3056 (0.5); 4.2712 (0.5); 4.1686 (1.1); 4.1510 (1.8); 4.1334 (1.4); 4.1255 (1.4); 4.1142 (1.6); 4.1083 (2.8); 4.1058 (2.7); 4.0963 (4.3); 4.0905 (3.6); 4.0882 (3.5); 4.0785 (4.2); 4.0729 (1.0); 4.0608 (1.5); 4.0506 (2.3); 4.0099 (1.6); 3.9699 (0.7); 3.9627 (0.6); 3.7635 (0.6); 3.7524 (0.8); 3.7433 (1.1); 3.7330 (1.2); 3.7217 (1.3); 3.7101 (1.5); 3.7005 (1.4); 3.6909 (1.2); 3.6657 (1.4); 3.5718 (5.9); 3.1659 (2.5); 3.0075 (0.6); 2.9870 (0.5); 2.9621 (0.6); 2.9552 (0.6); 2.8547 (1.0); 2.8448 (0.7); 2.8146 (1.1); 2.8041 (1.1); 2.7924 (0.7); 2.7627 (0.8); 2.7534 (0.8); 2.6790 (0.5); 2.6743 (1.1); 2.6697 (1.6); 2.6651 (1.1); 2.6604 (0.5); 2.6033 (2.0); 2.5843 (6.3); 2.5654 (6.2); 2.5456 (3.0); 2.5401 (1.6); 2.5358 (0.7); 2.5231 (3.7); 2.5185 (6.3); 2.5098 (90.4); 2.5052 (196.0); 2.5006 (275.0); 2.4960 (194.0); 2.4914 (87.1); 2.4766 (2.7); 2.4725 (2.5); 2.4678 (2.0); 2.4632 (1.1); 2.4590 (0.8); 2.4359 (1.1); 2.4137 (1.8); 2.3909 (2.2); 2.3735 (1.7); 2.3514 (1.2); 2.3368 (0.9); 2.3320 (1.3); 2.3274 (1.7); 2.3227 (1.3); 2.3181 (0.9); 2.2693 (1.3); 2.2565 (1.3); 2.2450 (1.9); 2.2318 (1.7); 2.2147 (0.8); 2.2034 (1.1); 2.1907 (1.0); 2.1214 (1.2); 2.1028 (1.3); 2.0843 (2.0); 2.0730 (2.1); 2.0473 (1.4); 1.9086 (1.0); 1.6587 (0.6); 1.6380 (1.6); 1.6276 (1.8); 1.6166 (1.9); 1.6060 (1.8); 1.5962 (1.9); 1.5855 (1.8); 1.5654 (1.5); 1.5330 (1.3); 1.5094 (0.6); 1.4999 (0.7); 1.4869 (0.8); 1.2173 (3.4); 1.1995 (6.1); 1.1900 (6.0); 1.1817 (7.3); 1.1777 (7.5); 1.1722 (15.2); 1.1643 (10.1); 1.1589 (13.6); 1.1572 (13.9); 1.1543 (16.0); 1.1458 (4.7); 1.1397 (6.4); 1.1381 (6.7); 0.0080 (3.4); -0.0002 (123.4); -0.0085 (3.7); -0.0333 (0.8) I.1-324:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.2668 (1.7); 8.2466 (1.8); 7.1437 (1.8); 7.1231 (8.0); 7.1112 (8.3); 7.0904 (1.8); 4.6609 (1.9); 4.6225 (2.0); 4.2420 (0.6); 4.2272 (0.8); 4.2193 (0.8); 4.2073 (1.0); 4.1841 (0.7); 4.0555 (2.0); 4.0174 (1.8); 3.7200 (0.6); 3.7097 (0.9); 3.6991 (1.1); 3.6887 (0.9); 3.6786 (0.7); 3.3760 (0.8); 3.3562 (1.6); 3.3244 (311.6); 3.2739 (2.1); 3.1676 (0.8); 2.6746 (1.0); 2.6701 (1.3); 2.6655 (0.9); 2.5236 (3.9); 2.5188 (5.2); 2.5102 (79.8); 2.5056 (175.6); 2.5010 (245.7); 2.4963 (171.1); 2.4918 (77.6); 2.4551 (1.6); 2.4505 (1.8); 2.4460 (1.4); 2.3660 (0.6); 2.3472 (1.2); 2.3278 (2.4); 2.3232 (1.8); 2.3061 (0.9); 2.2760 (16.0); 2.2546 (1.1); 2.2440 (1.2); 2.2299 (1.2); 2.2149 (1.6); 2.2016 (0.7); 2.1935 (1.5); 2.1812 (1.2); 2.1592 (1.1); 2.0729 (0.8); 2.0329 (0.6); 2.0203 (0.6); 2.0079 (0.7); 2.0006 (0.9); 1.9763 (0.7); 1.7170 (0.6); 1.7064 (0.7); 1.6954 (0.7); 1.6746 (0.6); 1.6014 (0.7); 1.5845 (0.7); 1.5699 (0.5); 1.5099 (1.4); 1.4991 (1.7); 1.4849 (2.2); 1.4739 (1.3); 1.4629 (1.2); 0.8910 (9.1); 0.8746 (8.8); 0.8248 (9.0); 0.8085 (8.8); 0.0080 (1.0); -0.0002 (34.1); -0.0085 (1.0) I.1-325:1H NMR (400.0MHz, d6-DMSO): δ= 7.4143 (3.5); 7.3966 (9.3); 7.3773 (7.7); 7.3360 (5.4); 7.3149 (4.4); 7.2941 (1.8); 7.2198 (10.3); 7.2165 (13.7); 7.1984 (10.2); 7.1280 (2.6); 7.1130 (2.5); 6.9106 (2.5); 4.5335 (2.1); 4.4938 (2.4); 4.1158 (2.5); 4.0738 (2.0); 3.8120 (2.3); 3.3795 (69.8); 3.1666 (4.9); 3.1037 (16.0); 2.6746 (1.9); 2.6700 (2.6); 2.6654 (1.8); 2.5546 (0.8); 2.5500 (1.0); 2.5404 (1.4); 2.5370 (0.7); 2.5234 (7.1); 2.5187 (11.0); 2.5101 (146.5); 2.5055 (316.7); 2.5009 (439.2); 2.4963 (307.5); 2.4917 (137.4); 2.4728 (2.3); 2.4679 (2.2); 2.4499 (0.8); 2.4273 (1.8); 2.3851 (2.0); 2.3808 (2.1); 2.3370 (1.2); 2.3323 (2.2); 2.3278 (2.8); 2.3231 (2.1); 2.2394 (3.8); 2.2185 (4.4); 2.2055 (3.8); 2.1769 (3.0); 2.1419 (2.2); 2.1213 (1.7); 2.0992 (1.8); 2.0733 (2.9); 2.0365 (1.2); 1.6575 (1.8); 0.0080 (3.2); -0.0002 (105.9); -0.0085 (3.0) I.1-326:1H NMR (400.0MHz, d6-DMSO): δ= 8.0055 (5.1); 7.9960 (5.0); 7.3809 (2.0); 7.3771 (2.1); 7.3604 (4.2); 7.3565 (4.6); 7.3505 (2.3); 7.3407 (3.0); 7.3347 (4.5); 7.3306 (3.9); 7.3141 (2.4); 7.3103 (2.3); 7.2073 (2.5); 7.2034 (2.7); 7.1945 (2.8); 7.1906 (3.4); 7.1874 (4.7); 7.1836 (5.0); 7.1746 (4.6); 7.1710 (5.1); 7.1672 (3.0); 7.1630 (2.9); 7.1542 (2.4); 7.1506 (2.6); 7.0670 (4.7); 7.0509 (6.4); 7.0315 (3.4); 4.7189 (7.5); 4.6791 (8.7); 4.2216 (9.4); 4.1817 (8.0); 3.8117 (1.5); 3.8006 (3.1); 3.7903 (4.2); 3.7802 (5.8); 3.7701 (4.3); 3.7599 (3.1); 3.7488 (1.6); 3.4239 (15.9); 3.1669 (0.9); 2.6750 (0.9); 2.6703 (1.2); 2.6658 (0.8); 2.6005 (1.0); 2.5906 (2.8); 2.5809 (4.0); 2.5724 (6.2); 2.5626 (6.6); 2.5539 (4.0); 2.5444 (3.2); 2.5342 (1.8); 2.5238 (4.0); 2.5191 (5.6); 2.5104 (75.1); 2.5059 (162.0); 2.5012 (225.4); 2.4967 (158.0); 2.4921 (71.3); 2.4711 (0.7); 2.4571 (7.3); 2.4453 (7.2); 2.4220 (8.3); 2.4102 (7.9); 2.3899 (1.8); 2.3703 (2.4); 2.3673 (2.3); 2.3478 (5.5); 2.3281 (6.5); 2.3056 (4.4); 2.2827 (4.4); 2.2692 (5.3); 2.2587 (6.5); 2.2453 (6.2); 2.2411 (2.6); 2.2274 (2.1); 2.2168 (3.3); 2.2037 (3.2); 2.1445 (8.8); 2.1296 (4.7); 2.1234 (9.5); 2.1175 (3.8); 2.1095 (9.2); 2.0982 (5.1); 2.0936 (3.5); 2.0881 (7.9); 2.0787 (2.9); 2.0741 (3.9); 2.0548 (1.5); 1.7474 (2.1); 1.7347 (3.0); 1.7240 (4.2); 1.7138 (3.4); 1.7025 (3.4); 1.6921 (3.8); 1.6816 (2.2); 1.6684 (1.6); 0.6075 (5.0); 0.5954 (12.4); 0.5904 (16.0); 0.5782 (15.3); 0.5725 (13.3); 0.5608 (5.8); 0.5390 (0.7); 0.5209 (0.6); 0.3885 (0.6); 0.3789 (0.6); 0.3484 (5.5); 0.3373 (14.4); 0.3313 (12.8); 0.3272 (12.7); 0.3217 (12.6); 0.3107 (4.2); 0.0080 (2.9); -0.0002 (93.3); -0.0085 (2.8) I.1-327:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.9099 (0.9); 7.1438 (2.0); 7.1236 (7.3); 7.1086 (8.0); 7.1031 (1.5); 7.0880 (2.1); 4.6644 (2.0); 4.6265 (2.2); 4.0109 (2.3); 3.9730 (2.0); 3.7199 (0.7); 3.7088 (1.0); 3.6984 (1.1); 3.6888 (0.9); 3.6778 (0.8); 3.3241 (48.4); 3.0688 (0.8); 3.0549 (1.1); 3.0507 (2.7); 3.0369 (2.9); 3.0326 (2.9); 3.0189 (2.8); 3.0147 (1.1); 3.0008 (0.9); 2.5229 (1.0); 2.5182 (1.4); 2.5095 (20.8); 2.5050 (45.0); 2.5003 (62.6); 2.4957 (43.2); 2.4911 (19.3); 2.4834 (1.9); 2.4719 (1.6); 2.4486 (1.8); 2.4374 (1.7); 2.3424 (1.2); 2.3227 (1.2); 2.3001 (0.9); 2.2758 (16.0); 2.2651 (1.3); 2.2512 (1.2); 2.2408 (1.4); 2.2271 (1.4); 2.2093 (0.6); 2.1989 (0.7); 2.1853 (0.7); 2.0985 (1.8); 2.0761 (1.8); 2.0711 (0.6); 2.0640 (1.6); 2.0488 (0.9); 2.0416 (1.6); 2.0363 (0.7); 2.0298 (0.5); 2.0247 (0.7); 2.0172 (1.0); 2.0123 (0.6); 1.9979 (0.6); 1.9930 (0.8); 1.7022 (0.6); 1.6913 (0.8); 1.6807 (0.7); 1.6695 (0.6); 1.6592 (0.7); 1.0000 (7.3); 0.9820 (15.7); 0.9639 (7.0) I.1-328:1H NMR (400.1 MHz, d6-DMSO): δ= 7.8524 (0.8); 7.8419 (0.8); 7.6457 (2.1); 7.1439 (1.9); 7.1233 (6.7); 7.1069 (7.3); 7.0864 (2.1); 7.0155 (5.2); 4.6677 (1.9); 4.6298 (2.1); 4.0010 (2.2); 3.9631 (2.0); 3.7275 (0.4); 3.7167 (0.8); 3.7057 (1.0); 3.6953 (1.2); 3.6855 (1.1); 3.6746 (0.9); 3.6638 (0.6); 3.3479 (3.8); 3.1713 (0.6); 2.5497 (9.8); 2.5382 (9.9); 2.5243 (0.5); 2.5189 (0.6); 2.5105 (8.4); 2.5061 (18.0); 2.5016 (25.5); 2.4971 (19.8); 2.4926 (9.5); 2.4857 (2.1); 2.4616 (1.7); 2.4506 (1.5); 2.3831 (0.4); 2.3644 (0.6); 2.3599 (0.5); 2.3411 (1.1); 2.3227 (1.0); 2.3186 (1.0); 2.2991 (0.9); 2.2756 (16.0); 2.2639 (1.5); 2.2564 (0.5); 2.2498 (1.2); 2.2396 (1.4); 2.2258 (1.3); 2.2080 (0.5); 2.1976 (0.7); 2.1840 (0.6); 2.1117 (1.6); 2.0892 (1.6); 2.0768 (1.4); 2.0690 (0.7); 2.0543 (1.4); 2.0495 (0.9); 2.0449 (0.5); 2.0367 (0.6); 2.0301 (0.5); 2.0252 (0.7); 2.0176 (0.9); 2.0129 (0.6); 2.0062 (0.4); 1.9982 (0.5); 1.9934 (0.7); 1.9742 (0.3); 1.9095 (0.4); 1.7078 (0.4); 1.6946 (0.6); 1.6837 (0.9); 1.6736 (0.7); 1.6620 (0.7); 1.6517 (0.8); 1.6409 (0.5); 1.6276 (0.3) I.1-329:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.6096 (3.8); 8.6453 (3.5); 8.6295 (4.5); 8.6128 (0.8); 8.2597 (1.8); 8.2360 (2.5); 8.2172 (2.0); 7.8831 (1.4); 7.8676 (2.4); 7.8325 (2.7); 7.8125 (2.7); 7.7945 (1.4); 7.1251 (4.2); 7.1192 (2.4); 7.1111 (2.4); 7.1050 (6.7); 7.0816 (7.4); 7.0611 (2.7); 4.8193 (0.6); 4.8045 (0.7); 4.7811 (1.6); 4.7666 (1.6); 4.7442 (1.6); 4.7305 (1.7); 4.7062 (0.7); 4.6924 (0.7); 4.6421 (2.3); 4.6257 (0.5); 4.6041 (2.5); 4.2998 (0.5); 4.1116 (0.6); 4.0739 (0.6); 4.0490 (0.5); 3.9870 (2.4); 3.9490 (2.1); 3.7538 (0.8); 3.7428 (1.0); 3.7318 (1.1); 3.7223 (1.0); 3.7116 (0.8); 3.5971 (0.5); 3.5798 (0.6); 3.1667 (2.7); 2.7678 (3.4); 2.7580 (2.9); 2.6705 (0.7); 2.6088 (1.2); 2.5982 (1.2); 2.5739 (1.4); 2.5632 (1.4); 2.5240 (1.3); 2.5193 (1.9); 2.5107 (33.4); 2.5060 (74.0); 2.5014 (103.9); 2.4968 (73.2); 2.4922 (32.8); 2.3375 (0.7); 2.3330 (0.6); 2.3283 (0.7); 2.3236 (0.7); 2.3184 (1.3); 2.2988 (1.1); 2.2947 (1.2); 2.2687 (16.0); 2.2552 (1.3); 2.2410 (1.5); 2.2367 (2.0); 2.2311 (1.6); 2.2143 (2.3); 2.2017 (1.6); 2.1890 (0.8); 2.1793 (1.6); 2.0736 (0.9); 2.0532 (0.8); 2.0488 (0.5); 2.0406 (0.6); 2.0339 (0.5); 2.0289 (0.7); 2.0217 (0.9); 2.0168 (0.6); 2.0021 (0.6); 1.9973 (0.7); 1.7126 (0.7); 1.7018 (1.0); 1.6913 (0.9); 1.6803 (0.9); 1.6696 (0.9); 1.6595 (0.6); 1.0699 (0.7); 1.0520 (1.6); 1.0339 (0.7); 1.0267 (0.6); 1.0093 (1.4); 0.9916 (0.6); 0.0080 (2.0); 0.0064 (0.6); 0.0056 (0.7); 0.0048 (0.8); 0.0039 (1.0); 0.0022 (2.8); -0.0002 (67.1); -0.0051 (0.9); -0.0059 (0.7); -0.0067 (0.6); -0.0085 (1.9) I.1-330:1H NMR (400.0MHz, d6-DMSO): δ= 7.9359 (3.3); 7.9214 (6.3); 7.9072 (3.3); 7.3843 (1.9); 7.3803 (2.1); 7.3636 (4.3); 7.3596 (4.6); 7.3538 (2.4); 7.3438 (3.0); 7.3377 (4.6); 7.3337 (4.0); 7.3175 (2.4); 7.3137 (2.3); 7.2093 (2.5); 7.2054 (2.6); 7.1966 (2.6); 7.1925 (3.3); 7.1890 (4.7); 7.1856 (5.0); 7.1765 (4.6); 7.1731 (5.1); 7.1691 (3.1); 7.1651 (3.0); 7.1562 (2.5); 7.1527 (2.7); 7.0727 (4.8); 7.0566 (6.5); 7.0372 (3.5); 4.7347 (7.5); 4.6948 (8.7); 4.2353 (9.3); 4.1954 (8.1); 3.8113 (3.1); 3.8002 (4.9); 3.7899 (6.5); 3.7798 (8.0); 3.7699 (6.8); 3.7596 (5.6); 3.7485 (3.8); 2.9174 (1.2); 2.9024 (1.8); 2.8849 (6.1); 2.8674 (11.6); 2.8523 (12.0); 2.8353 (5.9); 2.8174 (1.8); 2.8025 (1.3); 2.6770 (0.7); 2.6721 (1.0); 2.6674 (0.8); 2.5221 (7.9); 2.5121 (64.4); 2.5076 (133.3); 2.5030 (184.6); 2.4984 (130.0); 2.4938 (58.7); 2.4883 (11.4); 2.4762 (8.2); 2.4566 (0.9); 2.4004 (2.1); 2.3810 (2.4); 2.3585 (5.3); 2.3390 (5.4); 2.3355 (5.2); 2.3250 (1.4); 2.3162 (4.2); 2.2899 (4.0); 2.2764 (4.9); 2.2659 (6.0); 2.2525 (5.9); 2.2346 (2.2); 2.2240 (3.2); 2.2117 (9.7); 2.1907 (7.7); 2.1773 (6.5); 2.1559 (6.4); 2.1440 (2.2); 2.1245 (3.8); 2.1124 (2.8); 2.1052 (2.4); 2.1006 (3.5); 2.0931 (4.5); 2.0886 (2.9); 2.0813 (1.7); 2.0734 (2.7); 2.0689 (3.5); 2.0496 (1.5); 1.7686 (2.0); 1.7558 (2.8); 1.7451 (4.0); 1.7346 (3.4); 1.7237 (3.4); 1.7132 (3.6); 1.7027 (2.3); 1.6895 (2.0); 1.6558 (5.3); 1.6330 (16.0); 1.6060 (11.1); 1.3506 (1.7); 1.3411 (2.0); 1.3313 (2.5); 1.3235 (3.0); 1.3154 (2.6); 1.3045 (2.2); 1.2963 (2.0); 1.2783 (0.9); 1.1972 (1.3); 1.1666 (4.1); 1.1350 (8.7); 1.1196 (6.6); 1.1091 (6.2); 1.0787 (1.7); 1.0489 (0.6); 0.8691 (2.7); 0.8415 (5.9); 0.8164 (4.9); 0.7889 (1.7); 0.7801 (1.8); 0.0080 (1.0); -0.0002 (37.0); -0.0086 (1.1) I.1-331:1H NMR (400.0MHz, d6-DMSO): δ= 12.7492 (0.6); 8.4977 (1.2); 8.4764 (1.2); 8.3071 (1.5); 8.2884 (1.6); 8.1752 (1.6); 8.1533 (2.0); 8.1346 (1.2); 7.2623 (1.5); 7.2450 (4.7); 7.2410 (5.0); 7.2324 (12.1); 7.2264 (9.4); 7.2210 (8.2); 7.2057 (8.6); 7.1919 (7.2); 7.1725 (5.5); 7.1592 (8.4); 7.1560 (8.7); 7.1484 (5.0); 7.1410 (6.9); 7.1378 (6.5); 7.1300 (3.6); 7.1220 (1.7); 7.1108 (1.6); 7.0980 (3.0); 7.0813 (2.1); 7.0357 (2.3); 7.0206 (1.9); 4.6177 (3.0); 4.5783 (3.1); 4.5388 (0.8); 4.5212 (0.7); 4.4587 (0.9); 4.4466 (1.0); 4.4386 (1.1); 4.4270 (1.0); 4.4056 (0.6); 3.9611 (1.3); 3.9337 (1.8); 3.9225 (1.2); 3.8931 (1.5); 3.5973 (0.6); 3.5532 (3.0); 3.5374 (2.2); 3.3639 (85.4); 3.1673 (4.3); 3.0967 (1.3); 3.0759 (1.5); 3.0538 (1.3); 3.0408 (1.2); 2.9863 (0.9); 2.9620 (1.1); 2.9513 (1.0); 2.9423 (1.2); 2.9202 (1.2); 2.9079 (0.8); 2.8854 (0.8); 2.8490 (0.8); 2.8242 (0.8); 2.7906 (0.6); 2.6743 (4.1); 2.6696 (6.2); 2.6651 (5.0); 2.6605 (2.5); 2.6316 (1.3); 2.6052 (1.2); 2.5498 (2.2); 2.5451 (2.9); 2.5399 (3.6); 2.5350 (2.8); 2.5300 (2.5); 2.5231 (13.3); 2.5184 (21.2); 2.5097 (309.4); 2.5052 (669.1); 2.5006 (935.7); 2.4960 (657.9); 2.4914 (295.3); 2.4634 (1.8); 2.4587 (0.8); 2.4495 (0.9); 2.4450 (1.0); 2.4182 (2.3); 2.4077 (2.2); 2.3841 (2.9); 2.3742 (2.4); 2.3566 (1.3); 2.3367 (2.2); 2.3320 (4.3); 2.3273 (5.8); 2.3227 (4.3); 2.3183 (2.1); 2.2839 (1.6); 2.2598 (1.3); 2.2396 (1.1); 2.2193 (2.8); 2.1922 (16.0); 2.1831 (12.6); 2.1592 (1.4); 2.1370 (1.7); 2.1230 (1.4); 2.1119 (1.4); 2.0946 (1.6); 2.0857 (1.9); 2.0730 (2.3); 2.0618 (1.8); 2.0522 (1.4); 2.0284 (1.2); 1.7478 (0.9); 1.7244 (0.7); 1.6381 (0.6); 1.5491 (0.8); 1.2439 (0.7); 0.1462 (1.2); 0.0080 (10.5); -0.0002 (385.4); -0.0086 (11.6); -0.0332 (1.4); - 0.1497 (1.2) I.1-332:1H NMR (400.0MHz, CDCl3): δ= 7.2619 (25.2); 7.1191 (2.5); 7.1134 (29.1); 7.1062 (2.2); 7.0978 (2.6); 7.0901 (1.0); 7.0844 (2.3); 7.0030 (2.8); 6.9976 (0.9); 6.9866 (0.8); 6.9813 (4.7); 6.9758 (0.8); 6.9649 (0.7); 6.9596 (1.9); 5.3536 (0.6); 5.2980 (1.0); 4.7087 (1.8); 4.6712 (2.0); 4.1166 (1.8); 4.0791 (1.6); 3.9393 (0.6); 3.9292 (0.7); 3.9188 (1.1); 3.9084 (0.7); 3.8983 (0.6); 3.4713 (0.8); 3.4532 (1.3); 3.4427 (0.6); 3.4381 (1.2); 3.4253 (1.2); 3.4205 (0.6); 3.4105 (1.2); 3.3930 (0.7); 2.7523 (1.8); 2.7346 (3.6); 2.7170 (1.7); 2.4898 (1.4); 2.4784 (1.3); 2.4642 (0.9); 2.4539 (1.5); 2.4423 (2.2); 2.4216 (0.8); 2.4144 (0.9); 2.4001 (1.0); 2.3902 (1.1); 2.3761 (1.2); 2.3474 (0.6); 2.3330 (0.8); 2.3241 (16.0); 2.2019 (0.7); 2.1888 (0.5); 2.1779 (0.6); 2.1694 (0.8); 2.1647 (0.6); 2.1452 (0.7); 2.0716 (1.5); 2.0504 (1.5); 2.0356 (1.3); 2.0144 (1.3); 1.7359 (0.6); 1.7263 (0.6); 1.7130 (0.6); 1.7029 (0.5); -0.0002 (7.5) I.1-333:1H NMR (400.0MHz, d6-DMSO): δ= 8.9199 (1.7); 8.8986 (1.8); 7.3478 (2.0); 7.3425 (2.3); 7.3380 (1.4); 7.3269 (5.3); 7.3245 (4.2); 7.3216 (4.5); 7.3112 (5.0); 7.3055 (4.7); 7.2640 (8.3); 7.2544 (8.8); 7.2461 (5.9); 7.2363 (5.6); 7.2276 (1.3); 7.2219 (0.7); 7.2181 (0.9); 7.2054 (1.3); 7.1865 (3.1); 7.1677 (2.0); 7.0643 (1.8); 7.0454 (1.4); 6.9735 (3.2); 6.9508 (1.4); 6.1123 (2.2); 6.0911 (2.2); 4.6660 (1.9); 4.6276 (2.1); 3.9922 (2.1); 3.9538 (1.9); 3.7536 (0.6); 3.7431 (0.9); 3.7328 (1.0); 3.7227 (0.9); 3.7117 (0.6); 3.3152 (48.3); 2.6741 (0.6); 2.6694 (0.8); 2.6649 (0.6); 2.6531 (1.2); 2.6421 (1.2); 2.6185 (1.5); 2.6075 (1.4); 2.5308 (0.6); 2.5229 (2.3); 2.5182 (3.4); 2.5095 (46.1); 2.5050 (99.7); 2.5004 (139.2); 2.4958 (97.8); 2.4912 (43.8); 2.4673 (0.5); 2.3609 (0.5); 2.3416 (1.2); 2.3322 (2.1); 2.3272 (1.3); 2.3225 (1.7); 2.3104 (1.6); 2.2982 (2.0); 2.2754 (2.3); 2.2649 (16.0); 2.2509 (1.3); 2.2373 (1.2); 2.2089 (0.6); 2.1957 (0.6); 2.0729 (0.8); 2.0470 (0.7); 2.0346 (0.5); 2.0230 (0.7); 2.0152 (0.9); 1.9913 (0.7); 1.7403 (0.6); 1.7296 (0.8); 1.7196 (0.7); 1.7079 (0.7); 1.6978 (0.7); 0.0080 (1.9); -0.0002 (62.8); -0.0085 (1.8) I.1-334:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.4143 (3.5); 7.3966 (9.3); 7.3774 (7.7); 7.3357 (5.3); 7.3144 (4.4); 7.2936 (1.8); 7.2198 (10.2); 7.2166 (13.7); 7.1986 (10.3); 7.1265 (2.6); 7.1137 (2.5); 6.9103 (2.5); 4.5349 (2.1); 4.4944 (2.4); 4.1148 (2.5); 4.0751 (2.1); 3.8108 (2.4); 3.5617 (9.8); 3.1666 (2.1); 3.1039 (16.0); 2.6794 (0.6); 2.6747 (1.3); 2.6701 (1.8); 2.6655 (1.3); 2.6609 (0.6); 2.5512 (0.6); 2.5404 (1.0); 2.5236 (4.8); 2.5189 (7.4); 2.5102 (101.8); 2.5057 (220.3); 2.5011 (306.7); 2.4965 (214.8); 2.4919 (96.8); 2.4243 (1.8); 2.3894 (2.1); 2.3372 (0.9); 2.3325 (1.6); 2.3279 (2.1); 2.3233 (1.6); 2.2399 (3.8); 2.2185 (4.4); 2.2049 (3.8); 2.1774 (2.9); 2.1419 (2.2); 2.1229 (1.7); 2.0992 (1.8); 2.0735 (2.1); 2.0586 (1.4); 2.0369 (1.2); 1.6579 (1.8); 0.0080 (4.3); - 0.0002 (139.5); -0.0086 (4.0) I.1-337:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.3557 (0.7); 7.3346 (0.8); 7.2064 (0.5); 7.1867 (0.9); 7.1741 (0.8); 7.1701 (0.6); 7.0964 (0.6); 7.0807 (0.8); 4.7602 (0.8); 4.7216 (1.0); 4.7007 (0.5); 4.2677 (1.1); 4.2288 (1.0); 4.2046 (2.5); 4.0381 (3.8); 4.0344 (3.7); 3.8314 (0.6); 3.8214 (0.7); 3.8116 (0.7); 3.8014 (0.6); 3.6734 (7.6); 3.6199 (16.0); 3.3789 (32.3); 3.1663 (1.6); 2.9682 (14.8); 2.8497 (0.6); 2.8394 (0.6); 2.8092 (0.9); 2.7989 (0.8); 2.7689 (5.6); 2.6791 (0.5); 2.6744 (1.0); 2.6699 (1.3); 2.6652 (0.9); 2.5693 (1.0); 2.5469 (1.5); 2.5401 (1.2); 2.5344 (0.9); 2.5290 (1.4); 2.5233 (3.0); 2.5186 (4.7); 2.5099 (69.4); 2.5054 (150.9); 2.5007 (209.7); 2.4961 (147.6); 2.4916 (66.4); 2.4326 (0.6); 2.4082 (0.8); 2.3322 (1.0); 2.3275 (1.3); 2.3230 (1.0); 2.2558 (0.5); 2.2431 (0.8); 2.2318 (0.7); 2.2018 (0.6); 2.1947 (1.2); 2.1795 (0.6); 2.1478 (0.7); 1.6716 (0.5); 0.0080 (1.5); -0.0002 (51.2); -0.0086 (1.5) I.1-338:1H NMR (400.0 MHz, d6-DMSO): δ= 7.4209 (1.1); 7.4031 (2.7); 7.3842 (2.3); 7.3583 (0.9); 7.3409 (0.8); 7.1848 (3.9); 7.1811 (5.5); 7.1761 (1.5); 7.1636 (4.0); 7.1541 (0.6); 7.1296 (2.6); 7.1104 (3.1); 6.9988 (2.0); 6.9811 (1.5); 4.4267 (0.7); 4.3888 (0.8); 3.9487 (1.2); 3.9107 (1.2); 3.7862 (0.8); 3.7760 (1.0); 3.7662 (1.1); 3.7563 (0.9); 3.7463 (0.7); 3.1663 (0.7); 3.1072 (5.9); 2.6107 (1.5); 2.5917 (4.9); 2.5727 (5.0); 2.5537 (1.8); 2.5442 (0.5); 2.5384 (0.6); 2.5336 (0.8); 2.5235 (1.4); 2.5188 (2.0); 2.5101 (23.7); 2.5056 (50.5); 2.5010 (70.0); 2.4964 (48.9); 2.4918 (21.6); 2.4392 (0.6); 2.4104 (0.6); 2.4055 (0.7); 2.4008 (0.7); 2.2136 (1.2); 2.1996 (1.3); 2.1852 (1.0); 2.1063 (0.6); 2.0858 (0.6); 2.0734 (0.9); 2.0546 (0.6); 2.0031 (0.5); 1.6010 (0.5); 1.1927 (7.3); 1.1737 (16.0); 1.1547 (7.1); 0.0080 (1.2); -0.0002 (39.8); -0.0085 (1.1) I.1-339:1H NMR (400.0MHz, d6-DMSO): δ= 8.0320 (1.0); 7.1438 (1.9); 7.1236 (7.4); 7.1095 (8.2); 7.0889 (2.0); 4.6690 (2.0); 4.6312 (2.2); 4.0083 (2.2); 3.9701 (2.0); 3.7116 (0.6); 3.7010 (0.9); 3.6907 (1.1); 3.6806 (0.9); 3.6696 (0.7); 3.3116 (121.2); 3.2917 (5.4); 3.2606 (0.5); 3.2248 (38.3); 3.2048 (1.3); 3.2020 (1.3); 3.1916 (2.6); 3.1879 (2.5); 3.1782 (2.3); 3.1731 (1.9); 3.1682 (1.2); 3.1646 (0.9); 3.1585 (0.8); 2.6741 (0.6); 2.6695 (0.8); 2.6648 (0.6); 2.5230 (1.8); 2.5183 (2.6); 2.5096 (47.1); 2.5050 (101.4); 2.5004 (141.9); 2.4958 (100.0); 2.4912 (44.6); 2.4735 (2.2); 2.4623 (1.8); 2.3656 (0.6); 2.3461 (1.2); 2.3272 (1.8); 2.3229 (1.5); 2.3040 (0.9); 2.2758 (16.0); 2.2604 (1.0); 2.2470 (1.2); 2.2363 (1.3); 2.2228 (1.3); 2.2053 (0.6); 2.1944 (0.7); 2.1810 (0.7); 2.1501 (1.7); 2.1278 (1.7); 2.1156 (1.6); 2.0933 (1.4); 2.0716 (0.7); 2.0403 (0.8); 2.0277 (0.6); 2.0207 (0.5); 2.0160 (0.7); 2.0088 (0.9); 1.9843 (0.8); 1.7100 (0.6); 1.6993 (0.8); 1.6882 (0.7); 1.6765 (0.7); 1.6671 (0.7); -0.0002 (0.6) I.1-340:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.3790 (1.0); 7.3587 (2.4); 7.3373 (2.4); 7.3133 (1.2); 7.2083 (1.2); 7.1881 (2.4); 7.1758 (2.3); 7.1555 (1.2); 7.0974 (1.4); 7.0810 (2.4); 7.0613 (1.8); 5.0604 (2.1); 4.7896 (1.6); 4.7776 (1.3); 4.7532 (3.2); 4.7154 (2.2); 4.2889 (1.8); 4.2645 (2.1); 4.2490 (1.5); 4.2378 (1.1); 4.2237 (1.8); 4.1984 (0.9); 4.1817 (0.8); 4.1674 (1.5); 4.1501 (2.4); 4.1302 (2.6); 4.1231 (2.2); 4.1178 (1.8); 4.1124 (4.6); 4.1100 (4.0); 4.1052 (5.8); 4.0945 (3.8); 4.0922 (3.6); 4.0875 (5.7); 4.0766 (1.2); 4.0698 (1.8); 3.8478 (1.2); 3.8370 (1.0); 3.8262 (1.0); 3.8149 (1.0); 3.8028 (1.0); 3.7943 (1.0); 3.7835 (1.2); 3.7373 (1.3); 3.7079 (0.8); 3.5386 (9.0); 3.1670 (1.4); 3.0621 (0.6); 3.0306 (0.9); 3.0202 (1.0); 3.0122 (1.0); 2.9884 (0.5); 2.8968 (1.2); 2.8868 (1.0); 2.8572 (1.5); 2.8464 (1.2); 2.8397 (1.0); 2.8291 (0.9); 2.7991 (1.2); 2.7893 (1.1); 2.6749 (0.8); 2.6704 (1.1); 2.6658 (0.8); 2.5986 (1.3); 2.5909 (1.7); 2.5767 (1.9); 2.5589 (0.8); 2.5367 (1.6); 2.5237 (3.4); 2.5190 (5.0); 2.5103 (68.7); 2.5057 (148.7); 2.5011 (207.4); 2.4965 (144.5); 2.4919 (63.9); 2.4622 (1.5); 2.4540 (0.5); 2.4408 (1.9); 2.4316 (1.4); 2.4177 (1.5); 2.4002 (2.0); 2.3780 (1.4); 2.3326 (1.3); 2.3280 (1.4); 2.3234 (1.3); 2.3013 (0.7); 2.2778 (1.3); 2.2653 (1.3); 2.2533 (1.8); 2.2411 (1.8); 2.2331 (1.4); 2.2120 (1.7); 2.2045 (2.0); 2.1926 (1.7); 2.1706 (1.6); 2.1607 (1.5); 2.1408 (1.6); 2.1173 (1.4); 2.0967 (1.5); 2.0629 (1.4); 1.7127 (0.6); 1.6878 (1.3); 1.6471 (2.3); 1.6150 (2.7); 1.5438 (0.9); 1.5288 (0.9); 1.5101 (0.9); 1.4921 (0.9); 1.3803 (0.5); 1.3487 (0.7); 1.2852 (0.6); 1.2149 (5.0); 1.1971 (9.6); 1.1945 (9.0); 1.1891 (4.7); 1.1822 (8.6); 1.1794 (6.6); 1.1767 (16.0); 1.1713 (7.6); 1.1645 (15.0); 1.1589 (7.6); 1.1536 (3.6); 1.1467 (6.5); 0.0080 (2.5); -0.0002 (80.2); -0.0086 (2.3) I.1-341:1H NMR (400.0MHz, d6-DMSO): δ= 7.1804 (1.6); 7.1723 (5.2); 7.1678 (5.4); 7.1622 (2.6); 7.1547 (1.7); 7.1427 (1.2); 7.1037 (1.2); 7.0901 (1.0); 4.6999 (0.6); 4.6894 (1.2); 4.6610 (0.6); 4.6496 (1.3); 4.0858 (1.2); 4.0455 (1.1); 3.7002 (0.5); 3.6882 (0.7); 3.6777 (0.6); 3.6680 (0.6); 3.5945 (0.7); 3.5374 (16.0); 3.4021 (20.2); 3.2054 (0.8); 3.1879 (1.0); 3.1670 (1.0); 2.7499 (0.8); 2.7401 (0.8); 2.7259 (0.5); 2.7103 (1.0); 2.7005 (1.0); 2.6791 (0.7); 2.6744 (1.1); 2.6697 (1.5); 2.6651 (1.1); 2.5544 (0.5); 2.5498 (1.2); 2.5453 (1.6); 2.5400 (1.9); 2.5353 (1.4); 2.5301 (1.0); 2.5232 (4.0); 2.5185 (6.3); 2.5098 (83.7); 2.5052 (180.3); 2.5006 (251.0); 2.4960 (176.6); 2.4915 (80.0); 2.4703 (1.8); 2.4531 (0.7); 2.4445 (0.6); 2.4306 (1.6); 2.4137 (0.8); 2.3903 (0.8); 2.3761 (0.6); 2.3322 (1.5); 2.3275 (1.6); 2.3228 (1.2); 2.3088 (0.6); 2.2974 (0.6); 2.2843 (1.0); 2.2727 (1.0); 2.2670 (0.6); 2.2599 (0.7); 2.2469 (0.9); 2.2427 (0.9); 2.2317 (2.6); 2.2193 (13.2); 2.1913 (0.6); 2.1599 (0.8); 2.1353 (0.5); 1.7192 (0.5); 1.7097 (0.5); 1.0178 (0.7); 0.9998 (1.7); 0.9819 (0.7); 0.9667 (0.8); 0.9491 (1.9); 0.9313 (0.9); 0.8833 (1.3); 0.8739 (1.1); 0.8669 (1.4); 0.8577 (0.9); 0.8342 (0.9); 0.8281 (1.0); 0.8181 (1.4); 0.8079 (1.0); 0.8022 (0.8); 0.7919 (0.7); 0.0080 (1.3); -0.0002 (47.9); -0.0085 (1.4) I.1-342:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0995 (1.0); 7.1450 (1.8); 7.1247 (7.6); 7.1120 (8.4); 7.0913 (1.8); 5.8113 (0.5); 5.7980 (1.2); 5.7852 (1.0); 5.7723 (1.3); 5.7683 (0.7); 5.7590 (0.6); 5.7550 (1.4); 5.7421 (1.1); 5.7293 (1.4); 5.7160 (0.6); 5.1332 (0.7); 5.1288 (2.2); 5.1244 (2.3); 5.1199 (0.8); 5.0902 (0.6); 5.0857 (1.9); 5.0813 (2.0); 5.0770 (0.7); 5.0631 (0.8); 5.0591 (2.3); 5.0549 (2.1); 5.0509 (0.7); 5.0374 (0.8); 5.0334 (2.1); 5.0292 (2.0); 5.0253 (0.7); 4.6760 (2.0); 4.6379 (2.2); 4.0133 (2.3); 3.9753 (2.0); 3.7254 (0.7); 3.7144 (1.0); 3.7041 (1.0); 3.6938 (1.0); 3.6831 (2.2); 3.6697 (2.9); 3.6560 (1.5); 3.6532 (1.4); 3.3111 (79.1); 3.1683 (0.6); 2.6693 (0.5); 2.5493 (1.5); 2.5383 (1.7); 2.5227 (1.4); 2.5094 (30.7); 2.5048 (67.2); 2.5003 (92.4); 2.4957 (64.5); 2.4911 (29.2); 2.3492 (1.2); 2.3310 (1.3); 2.3270 (1.5); 2.3071 (0.9); 2.2760 (16.0); 2.2557 (1.2); 2.2454 (1.3); 2.2316 (1.3); 2.2140 (0.6); 2.2035 (0.7); 2.1899 (0.7); 2.1715 (1.8); 2.1489 (1.7); 2.1368 (1.5); 2.1141 (1.5); 2.0712 (0.6); 2.0561 (0.8); 2.0435 (0.6); 2.0319 (0.7); 2.0243 (0.9); 2.0194 (0.6); 2.0050 (0.6); 2.0002 (0.8); 1.7207 (0.6); 1.7097 (0.8); 1.6997 (0.7); 1.6879 (0.6); 1.6774 (0.7) I.1-346:1H NMR (400.0 MHz, CDCl3): δ= 7.5510 (1.7); 7.5480 (1.8); 7.5311 (1.9); 7.5280 (2.0); 7.2656 (1.2); 7.2618 (31.4); 7.2470 (1.8); 7.2439 (1.8); 7.2287 (1.6); 7.2255 (1.6); 7.1880 (1.7); 7.1837 (2.1); 7.1689 (1.1); 7.1647 (1.1); 7.1214 (1.6); 7.1130 (27.4); 7.1032 (1.6); 7.1016 (1.6); 7.0986 (1.4); 7.0970 (1.4); 7.0906 (0.6); 7.0834 (0.9); 7.0787 (0.8); 5.4350 (0.6); 5.2975 (2.6); 4.7045 (1.8); 4.6670 (2.0); 4.1255 (1.8); 4.0880 (1.6); 3.9441 (0.6); 3.9335 (0.8); 3.9234 (1.0); 3.9134 (0.8); 3.9027 (0.7); 3.5134 (0.8); 3.4957 (1.8); 3.4801 (2.1); 3.4636 (1.8); 3.4468 (0.8); 2.9380 (2.3); 2.9205 (4.6); 2.9030 (2.1); 2.5063 (1.3); 2.4949 (1.5); 2.4704 (1.8); 2.4587 (1.6); 2.4552 (0.9); 2.4533 (0.9); 2.4507 (0.9); 2.4309 (0.7); 2.4128 (0.9); 2.3987 (1.0); 2.3886 (1.1); 2.3746 (1.1); 2.3458 (0.6); 2.3317 (0.7); 2.3220 (16.0); 2.1953 (0.7); 2.1820 (0.5); 2.1711 (0.6); 2.1627 (0.9); 2.1579 (0.5); 2.1384 (0.7); 2.0789 (1.6); 2.0573 (1.5); 2.0427 (1.4); 2.0212 (1.3); 1.7530 (0.5); 1.7425 (0.7); 1.7325 (0.6); 1.7199 (0.6); 1.7095 (0.6); -0.0002 (9.8) I.1-347:1H NMR (400.0MHz, CDCl3): δ= 7.5189 (2.4); 7.3490 (1.5); 7.3293 (2.5); 7.3095 (2.6); 7.2916 (0.6); 7.2601 (442.4); 7.2105 (0.7); 7.1380 (0.6); 7.1156 (20.5); 7.1018 (2.4); 7.0828 (1.8); 6.9961 (4.2); 5.2334 (0.7); 4.6919 (1.9); 4.6547 (2.2); 4.1504 (2.0); 4.1128 (1.8); 3.9441 (0.7); 3.9334 (0.8); 3.9235 (1.2); 3.9141 (0.8); 3.9031 (0.7); 3.5006 (0.8); 3.4917 (0.5); 3.4828 (1.3); 3.4673 (1.3); 3.4442 (1.2); 3.4291 (1.3); 3.4113 (0.8); 2.8044 (2.1); 2.7870 (4.3); 2.7695 (2.0); 2.4961 (1.4); 2.4850 (1.4); 2.4683 (1.0); 2.4602 (1.5); 2.4488 (2.4); 2.4257 (0.8); 2.4190 (0.9); 2.4045 (1.1); 2.3948 (1.2); 2.3805 (1.3); 2.3519 (0.6); 2.3377 (0.6); 2.3210 (16.0); 2.2097 (0.8); 2.1963 (0.5); 2.1857 (0.6); 2.1776 (0.8); 2.1530 (0.7); 2.0640 (1.6); 2.0427 (1.6); 2.0278 (1.4); 2.0066 (1.8); 1.7427 (0.5); 1.7319 (0.7); 1.7222 (0.7); 1.7095 (0.7); 1.6986 (0.5); 1.5459 (33.9); 0.0080 (3.5); -0.0002 (117.5); -0.0085 (3.6) I.1-348:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.9220 (1.5); 8.9005 (1.5); 7.3943 (0.6); 7.3755 (1.2); 7.3729 (1.1); 7.3581 (1.8); 7.3476 (1.7); 7.3421 (1.3); 7.3396 (1.9); 7.3353 (1.4); 7.3314 (2.3); 7.3287 (3.6); 7.3265 (3.2); 7.3209 (5.2); 7.3182 (4.8); 7.3109 (4.6); 7.3029 (5.3); 7.2623 (2.5); 7.2530 (6.0); 7.2499 (6.7); 7.2345 (5.8); 7.2314 (3.4); 7.2297 (3.5); 7.2146 (1.5); 7.2106 (1.3); 7.1988 (3.3); 7.1956 (3.5); 7.1929 (2.9); 7.1783 (0.8); 7.1586 (0.8); 7.1534 (0.6); 7.1398 (1.6); 7.1340 (1.5); 7.1246 (1.1); 7.1188 (1.3); 7.1118 (2.0); 7.1086 (2.1); 7.0920 (0.7); 6.1076 (1.8); 6.0862 (1.8); 4.7515 (1.7); 4.7124 (1.9); 4.0426 (1.6); 4.0032 (1.5); 3.7133 (0.6); 3.7027 (0.8); 3.6918 (0.7); 3.4521 (3.7); 3.1667 (16.0); 2.6434 (0.9); 2.6324 (0.9); 2.6084 (1.2); 2.5978 (1.1); 2.5712 (0.8); 2.5522 (2.2); 2.5337 (2.4); 2.5229 (1.1); 2.5095 (22.9); 2.5050 (50.2); 2.5003 (70.5); 2.4957 (49.2); 2.4911 (21.7); 2.3931 (0.7); 2.3824 (1.3); 2.3721 (0.8); 2.3602 (1.3); 2.3479 (1.5); 2.3266 (1.4); 2.2769 (0.6); 2.2660 (0.7); 2.2525 (0.9); 2.2420 (0.8); 2.2104 (0.5); 2.0605 (0.5); 2.0378 (0.5); 2.0289 (0.7); 2.0061 (0.6); 1.7644 (0.7); 1.7552 (0.7); 1.1071 (5.3); 1.0883 (12.6); 1.0694 (5.2); 0.0079 (0.8); -0.0002 (27.1); -0.0085 (0.8) I.1-349:1H NMR (400.0MHz, d6-DMSO): δ= 7.8214 (4.4); 7.2304 (1.4); 7.2166 (4.2); 7.1896 (0.7); 7.1710 (1.1); 7.1633 (1.3); 7.1497 (1.1); 7.1410 (1.6); 7.1228 (1.0); 5.9803 (0.5); 4.8016 (1.1); 4.7619 (1.2); 4.7287 (0.7); 4.1215 (1.2); 4.0826 (1.1); 3.7849 (0.7); 3.5782 (12.4); 3.4873 (16.0); 3.2242 (3.0); 3.1860 (0.7); 3.1658 (1.0); 2.8426 (0.6); 2.7967 (0.7); 2.6743 (1.5); 2.6699 (2.2); 2.6652 (1.4); 2.6180 (1.7); 2.6002 (2.4); 2.5820 (1.3); 2.5400 (1.9); 2.5233 (5.3); 2.5186 (7.7); 2.5099 (112.4); 2.5053 (247.0); 2.5007 (345.6); 2.4961 (240.3); 2.4915 (106.3); 2.4321 (0.8); 2.3322 (1.5); 2.3274 (2.4); 2.3228 (1.5); 2.3015 (0.8); 2.2678 (0.6); 2.1625 (0.8); 1.8416 (0.5); 1.1493 (4.0); 1.1418 (1.7); 1.1305 (9.5); 1.1230 (3.6); 1.1117 (3.9); 1.1041 (1.7); 0.0080 (3.2); -0.0002 (121.1); -0.0086 (3.4) I.1-350:1H NMR (400.0MHz, d6-DMSO): δ= 10.8364 (3.1); 8.3208 (2.1); 8.3086 (2.3); 8.3010 (2.4); 8.2892 (2.0); 7.5306 (4.2); 7.5110 (4.4); 7.3301 (4.3); 7.3099 (4.9); 7.1204 (8.2); 7.1030 (6.7); 7.0791 (8.1); 7.0734 (6.0); 7.0681 (6.8); 7.0587 (5.3); 7.0559 (5.4); 7.0353 (2.8); 6.9941 (5.6); 6.9848 (3.9); 6.9741 (4.3); 6.9672 (4.2); 6.9651 (4.4); 6.9475 (2.0); 4.6162 (1.9); 4.5793 (2.5); 4.5468 (2.0); 4.5167 (0.7); 4.5041 (0.9); 4.4938 (1.7); 4.4815 (1.7); 4.4733 (1.6); 4.4610 (1.6); 4.4501 (0.8); 4.4381 (0.6); 4.0020 (2.1); 3.9639 (2.0); 3.8724 (2.2); 3.8341 (2.1); 3.6021 (2.6); 3.4973 (1.2); 3.4431 (2.0); 3.3438 (107.3); 3.1865 (1.9); 3.1743 (1.9); 3.1499 (2.6); 3.1384 (2.3); 3.0029 (1.9); 2.9956 (1.9); 2.9796 (2.0); 2.9721 (2.2); 2.9584 (1.6); 2.9430 (1.6); 2.9354 (1.5); 2.6704 (2.0); 2.6011 (2.0); 2.5058 (90.1); 2.5014 (117.7); 2.4971 (91.6); 2.4567 (3.0); 2.4445 (2.4); 2.3644 (0.7); 2.3327 (1.1); 2.3282 (1.3); 2.3111 (1.0); 2.2890 (1.8); 2.2638 (16.0); 2.2553 (15.1); 2.2268 (2.3); 2.2052 (1.2); 2.1926 (1.2); 2.1791 (1.4); 2.1739 (1.5); 2.1688 (1.7); 2.1507 (2.9); 2.1360 (2.0); 2.1264 (2.8); 2.1173 (2.2); 2.1024 (2.0); 2.0940 (2.3); 2.0853 (2.8); 2.0734 (6.2); 2.0707 (2.6); 1.9040 (0.8); 1.8913 (0.7); 1.8801 (0.8); 1.8717 (1.0); 1.8483 (0.8); 1.7845 (0.7); 1.7728 (0.6); 1.7613 (0.8); 1.7530 (0.9); 1.7295 (0.8); 1.6613 (0.7); 1.6506 (0.8); 1.6406 (0.9); 1.6286 (0.8); 1.6186 (0.7); 1.4158 (0.6); 1.4050 (0.8); 1.3948 (0.8); 1.3834 (0.8); 1.3729 (0.7); -0.0002 (6.4) I.1-351:1H NMR (400.0 MHz, i.e6-DMSO): δ= 12.7159 (1.6); 8.3393 (1.5); 8.3200 (1.5); 7.2542 (1.2); 7.2372 (3.2); 7.2324 (2.9); 7.2199 (7.4); 7.2060 (10.1); 7.1909 (3.5); 7.1834 (3.0); 7.1658 (1.5); 7.1466 (2.0); 7.1404 (1.7); 7.1308 (1.0); 7.1248 (1.0); 7.0815 (2.5); 7.0625 (1.7); 4.7171 (2.1); 4.6779 (2.4); 4.4317 (0.7); 4.4205 (1.0); 4.4071 (1.1); 4.3997 (1.0); 4.3872 (0.9); 3.9790 (2.1); 3.9390 (1.9); 3.5341 (1.0); 3.3118 (379.1); 3.1656 (0.9); 3.0778 (1.1); 3.0654 (1.2); 3.0424 (1.4); 3.0316 (1.3); 2.8309 (1.4); 2.8048 (1.5); 2.7961 (1.2); 2.7710 (1.1); 2.6790 (2.0); 2.6744 (4.0); 2.6697 (5.9); 2.6651 (4.0); 2.5940 (1.1); 2.5713 (2.7); 2.5561 (4.0); 2.5400 (4.2); 2.5232 (14.8); 2.5185 (21.6); 2.5098 (316.9); 2.5052 (689.5); 2.5006 (962.0); 2.4960 (677.0); 2.4914 (302.2); 2.4569 (1.8); 2.4473 (1.9); 2.4375 (1.4); 2.3367 (2.0); 2.3321 (4.2); 2.3274 (5.9); 2.3228 (4.6); 2.3000 (1.1); 2.2787 (1.0); 2.2577 (1.6); 2.2349 (0.9); 2.2012 (1.0); 2.1845 (1.7); 2.1774 (1.4); 2.1613 (2.0); 2.1504 (1.6); 2.1269 (1.6); 2.0731 (1.2); 1.9056 (0.8); 1.8735 (1.0); 1.8530 (0.9); 1.6915 (1.0); 1.1217 (7.0); 1.1029 (16.0); 1.0840 (6.6); 0.1459 (1.5); 0.0302 (0.6); 0.0142 (1.3); 0.0080 (14.8); 0.0063 (5.2); 0.0055 (5.7); 0.0046 (6.9); -0.0002 (475.2); -0.0060 (5.2); -0.0068 (4.5); -0.0085 (13.8); -0.0115 (1.9); -0.0140 (1.2); -0.0155 (1.1); -0.1497 (1.4) I.1-352:1H NMR (400.0MHz, d6-DMSO): δ= 8.9141 (1.9); 8.8929 (2.0); 7.3635 (0.5); 7.3443 (3.4); 7.3409 (3.7); 7.3371 (1.8); 7.3281 (4.4); 7.3254 (6.0); 7.3225 (7.0); 7.3199 (6.3); 7.3077 (5.1); 7.3064 (5.1); 7.3042 (6.0); 7.2603 (3.2); 7.2532 (12.8); 7.2450 (4.4); 7.2347 (7.2); 7.2332 (6.8); 7.2311 (5.7); 7.2264 (1.5); 7.2221 (0.9); 7.2180 (0.9); 7.1877 (0.6); 7.1839 (0.6); 7.1750 (0.6); 7.1712 (0.7); 7.1678 (1.0); 7.1642 (1.1); 7.1549 (1.0); 7.1517 (1.2); 7.1476 (0.7); 7.1437 (0.7); 7.1346 (0.6); 7.1313 (0.6); 7.0654 (1.1); 7.0494 (1.5); 7.0300 (0.8); 6.1062 (2.4); 6.0851 (2.4); 4.7257 (1.7); 4.6860 (2.0); 4.2208 (2.1); 4.1811 (1.8); 3.8225 (0.7); 3.8118 (1.0); 3.8016 (1.2); 3.7914 (1.0); 3.7810 (0.7); 3.3941 (5.4); 3.3384 (0.6); 3.1671 (16.0); 2.6715 (1.6); 2.6651 (0.7); 2.6606 (1.5); 2.6368 (1.7); 2.6258 (1.5); 2.5233 (1.9); 2.5186 (2.6); 2.5099 (29.6); 2.5054 (63.4); 2.5008 (87.9); 2.4962 (61.6); 2.4916 (27.1); 2.4554 (0.5); 2.4507 (0.6); 2.3843 (1.9); 2.3625 (2.1); 2.3495 (1.5); 2.3390 (1.3); 2.3276 (2.0); 2.3191 (1.4); 2.2967 (0.9); 2.2678 (0.9); 2.2547 (1.0); 2.2438 (1.3); 2.2308 (1.3); 2.2018 (0.6); 2.1891 (0.6); 2.1049 (0.8); 2.0930 (0.6); 2.0853 (0.5); 2.0811 (0.8); 2.0732 (1.2); 2.0536 (0.6); 2.0494 (0.8); 1.7786 (0.6); 1.7678 (0.9); 1.7578 (0.8); 1.7464 (0.8); 1.7362 (0.8); 0.0080 (0.8); -0.0002 (25.9); -0.0085 (0.7) I.1-353:1H NMR (400.0 MHz, i.e6-DMSO): δ= 10.7926 (1.6); 8.0592 (0.8); 8.0451 (1.6); 8.0306 (0.8); 7.5178 (2.2); 7.4980 (2.3); 7.3369 (1.9); 7.3347 (3.0); 7.3326 (2.0); 7.3167 (2.2); 7.3146 (3.6); 7.3124 (2.2); 7.1404 (2.5); 7.1205 (9.4); 7.1008 (7.9); 7.0802 (2.6); 7.0758 (1.7); 7.0728 (1.5); 7.0580 (2.0); 7.0553 (2.6); 7.0379 (1.7); 7.0350 (1.6); 6.9835 (2.0); 6.9809 (2.1); 6.9659 (1.8); 6.9636 (3.0); 6.9612 (2.2); 6.9463 (1.4); 6.9437 (1.4); 4.6629 (1.9); 4.6249 (2.2); 4.0034 (2.2); 3.9653 (2.0); 3.7194 (0.7); 3.7082 (0.9); 3.6975 (1.0); 3.6878 (0.9); 3.6770 (0.7); 3.3680 (40.1); 3.3427 (1.8); 3.3249 (2.4); 3.3102 (2.3); 3.2915 (1.2); 2.8068 (2.1); 2.7887 (3.5); 2.7704 (1.8); 2.5232 (0.8); 2.5185 (1.3); 2.5098 (22.1); 2.5053 (47.7); 2.5006 (66.6); 2.4960 (47.1); 2.4914 (20.5); 2.4733 (1.8); 2.4622 (1.6); 2.3502 (0.5); 2.3274 (1.5); 2.3082 (1.0); 2.2749 (16.0); 2.2519 (1.2); 2.2383 (1.2); 2.2279 (1.3); 2.2142 (1.3); 2.1964 (0.6); 2.1861 (0.7); 2.1724 (0.6); 2.1192 (1.6); 2.0967 (1.6); 2.0847 (1.4); 2.0621 (1.4); 2.0192 (0.8); 2.0147 (0.5); 2.0066 (0.6); 1.9951 (0.8); 1.9876 (0.9); 1.9828 (0.6); 1.9634 (0.8); 1.6758 (0.6); 1.6654 (0.8); 1.6549 (0.7); 1.6438 (0.7); 1.6331 (0.7); -0.0002 (3.3) I.1-355:1H NMR (400.0MHz, d6-DMSO): δ= 7.1786 (1.4); 7.1577 (4.6); 7.1378 (4.1); 7.1171 (1.4); 7.1093 (1.6); 7.0886 (0.7); 4.7069 (1.2); 4.6957 (0.6); 4.6688 (1.2); 4.1766 (2.4); 4.0614 (1.2); 4.0320 (5.9); 4.0235 (1.3); 3.9483 (0.6); 3.7206 (0.7); 3.7103 (0.6); 3.6726 (7.2); 3.6165 (16.0); 3.3883 (13.2); 3.1656 (1.7); 2.9334 (14.4); 2.8043 (0.7); 2.7949 (0.7); 2.7660 (5.8); 2.7547 (0.9); 2.6698 (1.3); 2.6650 (1.0); 2.6044 (0.9); 2.5852 (2.6); 2.5658 (2.8); 2.5472 (0.8); 2.5231 (2.1); 2.5184 (3.8); 2.5098 (71.5); 2.5052 (157.3); 2.5006 (220.5); 2.4960 (154.6); 2.4914 (69.7); 2.4725 (1.7); 2.4678 (1.5); 2.4639 (1.5); 2.4461 (1.8); 2.4240 (1.0); 2.3989 (0.8); 2.3752 (0.6); 2.3368 (1.0); 2.3319 (1.1); 2.3274 (1.4); 2.3227 (1.1); 2.2621 (0.5); 2.2497 (0.7); 2.2374 (0.8); 2.2255 (0.8); 2.0731 (1.0); 1.6253 (0.5); 1.6027 (0.5); 1.1839 (2.0); 1.1785 (4.2); 1.1650 (4.6); 1.1595 (9.6); 1.1460 (2.0); 1.1405 (4.1); 0.0080 (3.0); -0.0002 (115.4); -0.0086 (3.5); -0.0332 (0.6); -0.0506 (0.6) I.1-356:1H NMR (400.0MHz, d6-DMSO): δ= 8.1476 (0.6); 8.1335 (1.1); 8.1193 (0.5); 7.3701 (0.7); 7.3660 (0.8); 7.3439 (0.7); 7.1960 (0.7); 7.1921 (0.8); 7.1795 (0.8); 7.0823 (0.7); 7.0664 (1.0); 7.0468 (0.5); 4.7458 (1.1); 4.7061 (1.3); 4.2400 (1.4); 4.2005 (1.3); 3.7998 (0.7); 3.7896 (0.9); 3.7795 (0.7); 3.7691 (0.5); 3.3360 (47.4); 3.1857 (0.5); 3.1333 (1.0); 3.1148 (2.7); 3.1036 (3.3); 3.0965 (3.0); 3.0854 (2.8); 3.0781 (1.8); 3.0670 (1.0); 3.0248 (0.7); 3.0116 (1.0); 2.9984 (1.0); 2.9842 (1.1); 2.9725 (0.7); 2.5314 (1.1); 2.5197 (1.9); 2.5109 (16.0); 2.5063 (35.2); 2.5017 (49.4); 2.4970 (35.0); 2.4924 (15.3); 2.4849 (1.5); 2.3681 (0.8); 2.3490 (0.8); 2.3261 (0.8); 2.3009 (0.6); 2.2873 (0.8); 2.2768 (1.0); 2.2634 (0.9); 2.2350 (1.6); 2.2215 (0.5); 2.2137 (1.2); 2.1998 (1.0); 2.1784 (1.0); 2.1454 (0.6); 2.1214 (0.5); 2.1141 (0.7); 2.0897 (0.5); 2.0735 (1.1); 1.7614 (0.7); 1.7518 (0.9); 1.7357 (1.2); 1.7297 (1.1); 1.7165 (1.2); 1.7073 (1.0); 1.6946 (0.9); 1.1858 (7.0); 1.1677 (16.0); 1.1495 (6.7); -0.0002 (1.4) I.1-357:1H NMR (400.0 MHz, i.e6-DMSO): δ= 11.8206 (1.5); 7.2326 (1.0); 7.2291 (1.2); 7.2204 (1.9); 7.2176 (2.9); 7.2146 (4.5); 7.2017 (0.6); 7.1863 (0.9); 7.1796 (0.8); 7.1675 (1.2); 7.1602 (1.1); 7.1527 (0.6); 7.1459 (0.7); 7.1051 (1.6); 7.0867 (1.0); 4.7484 (1.5); 4.7089 (1.6); 4.0799 (1.4); 4.0407 (1.3); 3.7407 (0.5); 3.7292 (0.8); 3.7183 (0.5); 3.3981 (15.1); 3.1911 (16.0); 3.1657 (2.3); 2.7257 (0.8); 2.7156 (0.9); 2.6876 (1.1); 2.6776 (1.2); 2.6698 (0.9); 2.6652 (0.6); 2.6293 (0.6); 2.6257 (0.6); 2.6109 (1.7); 2.6069 (1.8); 2.5920 (1.9); 2.5882 (1.9); 2.5698 (0.8); 2.5401 (0.5); 2.5326 (0.5); 2.5233 (2.1); 2.5186 (3.1); 2.5099 (43.3); 2.5053 (94.4); 2.5007 (131.7); 2.4961 (92.3); 2.4915 (40.9); 2.4390 (0.6); 2.4317 (1.1); 2.4186 (0.7); 2.4092 (1.1); 2.3963 (1.2); 2.3713 (1.0); 2.3321 (0.6); 2.3275 (0.8); 2.3229 (0.6); 2.3114 (0.5); 2.3009 (0.7); 2.2869 (0.8); 2.2765 (0.8); 2.2450 (0.5); 2.2349 (0.5); 2.1669 (0.5); 2.1343 (0.6); 1.7642 (0.7); 1.7545 (0.6); 1.1511 (4.8); 1.1324 (11.3); 1.1135 (4.7); 0.0080 (2.1); 0.0064 (0.6); 0.0055 (0.7); 0.0047 (0.9); 0.0039 (1.1); -0.0002 (66.5); -0.0059 (0.7); -0.0067 (0.6); -0.0085 (1.9) I.1-358:1H NMR (400.0 MHz, i.e6-DMSO): δ= 12.7555 (1.2); 8.3581 (1.8); 8.3378 (2.1); 7.2800 (1.8); 7.2618 (4.3); 7.2440 (5.2); 7.2321 (1.6); 7.2148 (8.4); 7.2066 (5.7); 7.1980 (9.5); 7.1945 (9.5); 7.1858 (3.4); 7.1679 (1.1); 7.1602 (1.5); 7.1534 (1.1); 7.1410 (2.2); 7.1344 (1.7); 7.1258 (1.1); 7.1195 (1.0); 7.0805 (3.3); 7.0612 (2.1); 4.7139 (2.4); 4.6744 (2.7); 4.4933 (0.7); 4.4821 (0.8); 4.4687 (1.1); 4.4605 (1.1); 4.4474 (0.9); 4.4358 (0.8); 4.0230 (2.3); 3.9834 (2.3); 3.5631 (1.2); 3.3137 (221.5); 3.1655 (1.2); 3.0910 (1.2); 3.0793 (1.4); 3.0563 (1.6); 3.0448 (1.5); 2.8332 (1.6); 2.8077 (1.9); 2.7991 (1.7); 2.7739 (1.3); 2.6743 (1.7); 2.6697 (2.4); 2.6652 (1.8); 2.5827 (3.3); 2.5787 (3.4); 2.5641 (3.2); 2.5399 (3.5); 2.5231 (9.2); 2.5097 (149.9); 2.5052 (307.9); 2.5007 (417.4); 2.4961 (298.5); 2.4916 (138.7); 2.4493 (1.8); 2.4391 (1.8); 2.3947 (0.7); 2.3321 (2.3); 2.3275 (2.8); 2.3228 (2.1); 2.2929 (1.3); 2.2722 (1.7); 2.2497 (0.9); 2.2002 (1.0); 2.1898 (1.3); 2.1763 (1.4); 2.1613 (2.4); 2.1483 (1.0); 2.1385 (1.8); 2.1271 (1.9); 2.1041 (1.4); 2.0731 (1.0); 1.8053 (0.8); 1.7853 (0.8); 1.7749 (1.0); 1.7527 (0.8); 1.4425 (0.7); 1.4182 (1.0); 1.4083 (1.0); 1.1223 (7.5); 1.1035 (16.0); 1.0847 (7.1); 0.1461 (0.5); 0.0079 (6.0); -0.0002 (163.4); -0.0085 (6.2); -0.1496 (0.6) I.1-359:1H NMR (400.0MHz, d6-DMSO): δ= 8.8770 (2.3); 8.8727 (2.5); 8.8665 (2.5); 8.8622 (2.5); 8.6378 (0.8); 8.6231 (1.5); 8.6083 (0.7); 8.3395 (1.4); 8.3370 (1.5); 8.3183 (1.6); 8.3159 (1.5); 7.9876 (2.6); 7.9660 (2.9); 7.7767 (2.6); 7.7733 (2.7); 7.6512 (2.2); 7.6463 (2.0); 7.6295 (1.9); 7.6245 (1.8); 7.5414 (2.5); 7.5309 (2.4); 7.5207 (2.4); 7.5102 (2.4); 7.1485 (0.7); 7.1295 (3.0); 7.1098 (8.4); 7.0980 (8.4); 7.0919 (2.0); 7.0826 (0.9); 7.0771 (1.9); 4.6895 (1.8); 4.6514 (2.0); 4.4621 (1.7); 4.4482 (3.1); 4.4343 (1.7); 4.0218 (2.0); 4.0107 (0.5); 3.9839 (1.8); 3.7722 (0.7); 3.7614 (0.9); 3.7507 (1.0); 3.7411 (0.9); 3.7304 (0.7); 3.3420 (12.1); 3.1665 (5.7); 3.1518 (0.6); 3.1344 (0.6); 3.1162 (0.6); 3.0085 (0.5); 2.7663 (3.1); 2.7570 (2.6); 2.6703 (0.6); 2.6323 (1.4); 2.6215 (1.3); 2.5974 (1.5); 2.5867 (1.4); 2.5516 (0.6); 2.5238 (1.1); 2.5191 (1.7); 2.5104 (29.4); 2.5058 (65.2); 2.5012 (91.5); 2.4966 (64.5); 2.4920 (29.0); 2.4039 (0.6); 2.3840 (0.7); 2.3614 (1.2); 2.3424 (1.0); 2.3377 (1.0); 2.3328 (0.6); 2.3280 (0.8); 2.3188 (1.1); 2.2781 (4.3); 2.2671 (16.0); 2.2583 (2.3); 2.2475 (2.1); 2.2447 (1.8); 2.2350 (1.6); 2.2270 (0.8); 2.2128 (1.5); 2.2026 (0.7); 2.1077 (0.6); 2.0885 (0.7); 2.0839 (0.5); 2.0761 (0.6); 2.0737 (0.6); 2.0695 (0.5); 2.0643 (0.7); 2.0571 (0.9); 2.0521 (0.6); 2.0376 (0.5); 2.0327 (0.7); 1.7924 (0.8); 1.7793 (0.8); 1.7687 (1.0); 1.7579 (0.7); 1.7471 (0.7); 1.7365 (0.7); 1.7260 (0.5); 1.1941 (1.0); 1.1759 (2.0); 1.1576 (1.0); 1.0701 (1.6); 1.0521 (3.6); 1.0342 (1.6); 0.0081 (1.7); -0.0002 (63.2); -0.0085 (1.9) I.1-360:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4942 (4.6); 8.4801 (9.1); 8.4658 (4.6); 7.3832 (2.4); 7.3792 (2.7); 7.3629 (9.3); 7.3527 (3.5); 7.3415 (12.6); 7.3327 (5.6); 7.3247 (10.1); 7.3197 (6.8); 7.3126 (3.3); 7.3030 (5.2); 7.2408 (6.2); 7.2344 (6.5); 7.2173 (7.2); 7.2146 (7.8); 7.2109 (8.0); 7.2082 (8.1); 7.2046 (4.1); 7.2005 (3.8); 7.1912 (9.3); 7.1846 (12.3); 7.1809 (6.8); 7.1716 (5.7); 7.1682 (6.4); 7.1643 (4.0); 7.1602 (3.7); 7.1512 (3.2); 7.1478 (3.4); 7.0717 (8.1); 7.0690 (10.1); 7.0655 (8.6); 7.0505 (15.9); 7.0481 (16.0); 7.0441 (10.6); 7.0417 (9.1); 7.0326 (4.9); 7.0292 (6.7); 7.0267 (5.3); 7.0226 (3.9); 7.0202 (3.8); 4.7280 (9.4); 4.6882 (10.8); 4.2834 (0.8); 4.2693 (1.0); 4.2412 (12.7); 4.2308 (13.0); 4.2180 (13.0); 4.2029 (1.3); 4.1780 (10.4); 3.8238 (3.0); 3.8131 (5.3); 3.8026 (7.3); 3.7924 (8.9); 3.7824 (8.3); 3.7719 (7.4); 3.7608 (6.2); 3.7323 (6.0); 2.6765 (1.3); 2.6719 (1.8); 2.6673 (1.3); 2.5923 (7.7); 2.5810 (7.7); 2.5573 (8.8); 2.5458 (8.3); 2.5254 (5.2); 2.5207 (7.8); 2.5119 (100.3); 2.5074 (218.4); 2.5028 (303.3); 2.4982 (214.5); 2.4936 (95.6); 2.4578 (1.7); 2.4532 (1.8); 2.4485 (1.1); 2.3866 (2.1); 2.3670 (2.9); 2.3444 (6.6); 2.3342 (2.0); 2.3249 (7.8); 2.3021 (5.3); 2.2789 (5.6); 2.2719 (10.6); 2.2657 (7.1); 2.2549 (8.9); 2.2503 (10.8); 2.2417 (8.7); 2.2369 (11.2); 2.2238 (3.0); 2.2148 (9.5); 2.2000 (3.8); 2.1410 (2.6); 2.1216 (4.7); 2.1174 (3.0); 2.1094 (3.5); 2.1021 (3.0); 2.0977 (4.3); 2.0900 (5.8); 2.0857 (3.6); 2.0783 (2.2); 2.0704 (3.2); 2.0660 (4.3); 2.0466 (1.8); 1.7666 (2.4); 1.7540 (3.6); 1.7432 (5.0); 1.7331 (4.3); 1.7217 (4.2); 1.7114 (4.4); 1.7009 (2.6); 1.6878 (1.9); 0.0080 (3.5); -0.0002 (114.0); -0.0085 (3.3); -0.0499 (0.6) I.1-361:1H NMR (400.0MHz, d6-DMSO): δ= 10.4717 (6.2); 10.4673 (6.3); 8.0564 (2.9); 8.0424 (6.0); 8.0283 (3.0); 7.3806 (1.5); 7.3767 (1.6); 7.3601 (3.2); 7.3561 (3.5); 7.3503 (1.9); 7.3404 (2.3); 7.3341 (3.5); 7.3302 (3.1); 7.3140 (1.9); 7.3101 (1.9); 7.2094 (1.9); 7.2055 (2.1); 7.1966 (2.0); 7.1929 (2.5); 7.1894 (3.6); 7.1858 (4.0); 7.1766 (3.5); 7.1733 (4.0); 7.1692 (2.4); 7.1652 (2.4); 7.1563 (2.0); 7.1528 (2.2); 7.1191 (14.0); 7.1181 (14.5); 7.0977 (15.2); 7.0966 (16.0); 7.0758 (3.8); 7.0597 (5.1); 7.0565 (4.9); 7.0403 (2.7); 7.0115 (10.8); 7.0060 (10.6); 6.8070 (12.8); 6.8013 (13.5); 6.5921 (8.9); 6.5864 (8.4); 6.5706 (8.2); 6.5650 (8.0); 4.7455 (5.8); 4.7058 (6.7); 4.2352 (7.3); 4.1955 (6.5); 3.8190 (9.1); 3.8084 (10.1); 3.7979 (10.6); 3.7878 (10.7); 3.7778 (9.2); 3.7673 (7.4); 3.7565 (5.4); 3.5746 (0.7); 3.3148 (0.8); 3.3007 (2.5); 3.2824 (5.1); 3.2689 (5.6); 3.2574 (5.1); 3.2397 (2.7); 3.2252 (0.8); 3.1692 (2.7); 2.7061 (6.9); 2.6876 (12.8); 2.6693 (6.5); 2.5408 (0.7); 2.5275 (4.9); 2.5244 (3.5); 2.5192 (4.6); 2.5108 (55.1); 2.5062 (120.4); 2.5016 (168.8); 2.4969 (119.4); 2.4924 (58.0); 2.4813 (6.4); 2.3951 (1.4); 2.3754 (1.9); 2.3722 (2.0); 2.3529 (4.1); 2.3331 (4.6); 2.3190 (0.9); 2.3106 (3.1); 2.2751 (3.0); 2.2618 (3.7); 2.2510 (4.6); 2.2378 (4.4); 2.2334 (2.2); 2.2200 (1.9); 2.2089 (3.0); 2.2036 (6.0); 2.1962 (2.9); 2.1820 (5.6); 2.1688 (4.8); 2.1472 (4.7); 2.1271 (1.6); 2.1076 (2.8); 2.1034 (1.9); 2.0953 (2.2); 2.0881 (1.9); 2.0836 (2.7); 2.0760 (3.6); 2.0730 (6.9); 2.0644 (1.4); 2.0564 (2.0); 2.0519 (2.6); 2.0324 (1.2); 1.7572 (1.5); 1.7447 (2.2); 1.7339 (3.0); 1.7235 (2.6); 1.7124 (2.6); 1.7020 (2.7); 1.6912 (1.6); 1.6784 (1.2); -0.0002 (6.7) I.1-362:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.9622 (0.5); 7.1434 (0.9); 7.1232 (3.1); 7.1082 (3.4); 7.1027 (0.6); 7.0875 (0.9); 4.6629 (0.8); 4.6249 (0.9); 4.0121 (0.9); 3.9741 (0.8); 3.5746 (16.0); 3.5056 (1.8); 3.0376 (1.0); 3.0337 (0.8); 3.0234 (0.8); 3.0196 (1.0); 2.5105 (3.6); 2.5060 (8.0); 2.5013 (11.6); 2.4967 (7.8); 2.4921 (3.7); 2.4666 (0.7); 2.4556 (0.7); 2.3072 (1.3); 2.3019 (0.5); 2.2885 (2.7); 2.2751 (6.9); 2.2702 (2.6); 2.2562 (0.5); 2.2460 (0.6); 2.2320 (0.5); 2.1100 (0.7); 2.0875 (0.7); 2.0753 (0.6); 2.0528 (0.6); 1.6560 (0.6); 1.6388 (1.2); 1.6204 (1.6); 1.6024 (1.0); -0.0002 (0.6) I.1-363:1H NMR (400.0MHz, d6-DMSO): δ= 9.1990 (1.9); 9.1917 (1.8); 8.3022 (0.5); 8.2973 (0.5); 7.1311 (0.9); 7.1107 (2.3); 7.0920 (1.7); 7.0748 (1.7); 7.0547 (0.7); 6.9941 (1.7); 6.9734 (2.0); 6.6563 (1.4); 6.6509 (0.6); 6.6469 (1.5); 6.6408 (0.7); 6.6350 (1.3); 6.6304 (0.6); 6.6255 (1.3); 3.3215 (48.3); 3.2978 (2.4); 2.5101 (7.2); 2.5055 (15.5); 2.5009 (21.9); 2.4963 (15.2); 2.4917 (7.0); 2.4665 (0.6); 2.2688 (4.5); 2.0851 (3.3); 2.0725 (2.1); 1.3289 (16.0); 1.3189 (15.4); -0.0002 (16.2); -0.0028 (0.9) I.1-365:1H NMR (400.1 MHz, CDCl3): δ= 7.5206 (1.2); 7.3094 (0.6); 7.2903 (0.4); 7.2618 (208.0); 7.2093 (0.4); 7.1312 (0.4); 7.1177 (0.8); 7.1064 (1.5); 7.0961 (1.0); 7.0888 (1.6); 7.0817 (1.7); 7.0728 (1.0); 7.0631 (6.2); 7.0529 (5.7); 7.0444 (2.2); 7.0395 (1.8); 6.9978 (1.2); 4.9135 (2.3); 4.8746 (2.5); 4.7178 (1.0); 4.7067 (1.0); 4.6906 (2.0); 4.6796 (2.0); 4.6635 (1.1); 4.6521 (1.0); 4.2430 (3.1); 4.2044 (2.9); 3.8931 (0.5); 3.8831 (0.9); 3.8726 (1.3); 3.8623 (1.5); 3.8510 (1.3); 3.8402 (0.9); 3.8304 (0.5); 2.7332 (2.0); 2.7239 (2.0); 2.6955 (2.5); 2.6862 (2.4); 2.5623 (0.5); 2.5439 (0.7); 2.5389 (0.7); 2.5202 (1.8); 2.5012 (1.5); 2.4963 (1.3); 2.4776 (1.4); 2.4394 (1.2); 2.4252 (1.4); 2.4149 (1.7); 2.4020 (4.0); 2.3796 (2.7); 2.3720 (1.2); 2.3647 (2.3); 2.3581 (1.1); 2.3420 (2.0); 2.2946 (0.7); 2.2754 (1.1); 2.2699 (0.7); 2.2623 (0.9); 2.2560 (0.8); 2.2515 (0.9); 2.2432 (1.2); 2.2376 (0.8); 2.2323 (0.5); 2.2234 (0.8); 2.2184 (0.9); 2.1989 (0.5); 1.9539 (1.2); 1.9239 (1.3); 1.9009 (0.6); 1.8883 (0.9); 1.8762 (1.2); 1.8663 (1.0); 1.8530 (1.0); 1.8429 (1.1); 1.8321 (0.8); 1.8185 (0.9); 1.8074 (1.0); 1.8008 (1.0); 1.7898 (1.4); 1.7837 (1.2); 1.7725 (1.0); 1.7654 (1.0); 1.7544 (0.4); 1.7487 (0.4); 1.6932 (2.4); 1.6669 (2.4); 1.6610 (2.5); 1.6525 (1.6); 1.6058 (0.5); 1.5582 (142.5); 1.5209 (0.4); 1.5050 (0.7); 1.4818 (1.0); 1.4741 (1.0); 1.4660 (0.9); 1.4361 (0.5); 1.4284 (0.4); 1.3964 (0.5); 1.3897 (0.9); 1.3819 (0.5); 1.3595 (1.5); 1.3388 (0.7); 1.3309 (1.0); 1.3237 (0.6); 1.0960 (0.4); 1.0857 (0.5); 1.0594 (1.1); 1.0533 (1.3); 1.0283 (1.5); 1.0213 (1.2); 0.9961 (1.6); 0.9665 (2.3); 0.9381 (2.5); 0.9105 (15.1); 0.8991 (16.0); 0.8943 (14.6); 0.8818 (14.2); 0.8477 (1.0); 0.8190 (0.5); 0.7477 (13.4); 0.7303 (12.9); 0.1460 (0.4); 0.0074 (4.4) I.1-366:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1490 (2.2); 7.1288 (7.6); 7.1149 (7.5); 7.1000 (2.1); 7.0946 (1.9); 7.0767 (1.2); 5.0631 (1.0); 5.0498 (1.0); 4.7472 (1.2); 4.7091 (1.6); 4.7004 (1.1); 4.6620 (1.4); 4.2185 (1.2); 4.2132 (1.2); 4.2007 (1.3); 4.1955 (1.4); 4.1779 (0.6); 4.1690 (0.9); 4.1514 (1.4); 4.1337 (1.1); 4.1266 (1.1); 4.1156 (1.7); 4.1089 (2.1); 4.1059 (1.8); 4.0977 (3.6); 4.0912 (1.9); 4.0882 (1.7); 4.0799 (3.3); 4.0706 (1.4); 4.0621 (1.0); 4.0352 (1.3); 3.9976 (1.0); 3.9528 (0.5); 3.7401 (0.5); 3.7273 (0.8); 3.7173 (1.1); 3.7077 (1.1); 3.6979 (0.7); 3.6841 (0.8); 3.3160 (77.1); 3.2923 (2.8); 3.0160 (3.0); 2.9754 (0.7); 2.9687 (0.6); 2.8546 (0.6); 2.8446 (0.5); 2.8149 (0.7); 2.8037 (0.8); 2.7923 (0.5); 2.7622 (0.8); 2.7531 (0.8); 2.6698 (0.5); 2.5401 (0.5); 2.5233 (2.0); 2.5186 (2.7); 2.5099 (31.4); 2.5054 (67.6); 2.5007 (94.4); 2.4961 (65.4); 2.4916 (29.4); 2.4774 (1.0); 2.4665 (0.5); 2.4616 (0.8); 2.4511 (0.5); 2.4380 (0.7); 2.4300 (0.6); 2.4132 (1.2); 2.3902 (1.4); 2.3739 (1.0); 2.3509 (0.9); 2.3324 (0.6); 2.3276 (0.6); 2.2742 (16.0); 2.2522 (1.1); 2.2408 (1.3); 2.2280 (1.5); 2.2106 (0.6); 2.1990 (0.8); 2.1865 (0.8); 2.1312 (0.5); 2.1123 (0.8); 2.0922 (1.4); 2.0874 (1.3); 2.0729 (1.0); 2.0648 (1.0); 2.0550 (1.1); 2.0452 (1.0); 1.6554 (0.7); 1.6346 (1.6); 1.6240 (1.6); 1.6129 (1.5); 1.6006 (1.6); 1.5927 (1.6); 1.5830 (1.3); 1.5691 (1.2); 1.5377 (0.9); 1.5277 (0.6); 1.5029 (0.5); 1.4921 (0.5); 1.2430 (3.0); 1.2253 (6.4); 1.2178 (2.6); 1.2075 (3.7); 1.2001 (5.5); 1.1905 (4.5); 1.1862 (2.9); 1.1823 (3.3); 1.1729 (10.3); 1.1685 (4.4); 1.1558 (9.8); 1.1509 (2.3); 1.1382 (3.8); -0.0002 (7.6) I.1-367:1H NMR (400.0MHz, d6-DMSO): δ= 8.2132 (1.0); 8.1942 (1.0); 7.1773 (0.7); 7.1704 (0.5); 7.1568 (2.4); 7.1495 (0.9); 7.1391 (2.4); 7.1185 (0.7); 7.1101 (0.6); 6.9512 (1.0); 6.9322 (1.0); 4.7072 (0.6); 4.6691 (0.6); 4.0642 (0.6); 4.0583 (0.9); 3.9375 (2.1); 3.3166 (4.3); 3.1608 (16.0); 3.1228 (1.4); 3.1045 (4.6); 3.0863 (4.7); 3.0681 (1.4); 2.9165 (4.6); 2.7642 (2.0); 2.6699 (0.6); 2.6651 (0.6); 2.6045 (0.5); 2.5851 (1.4); 2.5663 (1.2); 2.5451 (0.5); 2.5233 (1.5); 2.5186 (2.2); 2.5100 (27.5); 2.5054 (59.0); 2.5008 (81.8); 2.4962 (57.2); 2.4916 (25.3); 2.4679 (0.6); 2.4548 (0.6); 2.4501 (1.0); 2.4456 (1.2); 2.4409 (0.7); 2.3276 (0.7); 1.1919 (5.0); 1.1830 (2.0); 1.1787 (2.1); 1.1737 (10.8); 1.1641 (4.0); 1.1598 (4.0); 1.1554 (5.0); 1.1451 (1.7); 1.1408 (1.7); 0.0080 (1.4); -0.0002 (43.6); -0.0085 (1.2); -0.0507 (0.5) I.1-368:1H NMR (400.0MHz, d6-DMSO): δ= 7.4192 (1.8); 7.4014 (4.6); 7.3828 (3.9); 7.3560 (1.6); 7.3394 (1.5); 7.1810 (8.6); 7.1773 (12.9); 7.1721 (5.7); 7.1598 (13.0); 7.1570 (16.0); 7.1430 (1.7); 7.1296 (1.5); 7.1241 (1.5); 7.1112 (1.9); 6.9189 (1.5); 6.9024 (1.3); 4.5229 (1.2); 4.4835 (1.3); 4.0986 (0.6); 4.0589 (0.5); 3.9052 (1.4); 3.8662 (1.2); 3.7476 (1.3); 3.7376 (1.5); 3.7286 (1.3); 3.0944 (9.2); 2.5236 (0.8); 2.5188 (1.1); 2.5102 (15.9); 2.5056 (34.6); 2.5010 (48.4); 2.4964 (34.3); 2.4918 (15.6); 2.4045 (1.0); 2.3661 (1.1); 2.3279 (0.5); 2.2610 (1.2); 2.2230 (3.4); 2.2109 (2.6); 2.1587 (13.1); 2.1216 (1.4); 2.1108 (1.6); 2.0909 (1.6); 2.0730 (2.2); 2.0381 (0.7); 1.6701 (1.0); -0.0002 (15.4) I.1-369:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.9728 (8.7); 7.5405 (10.7); 7.5377 (13.4); 7.5329 (4.1); 7.5188 (15.3); 7.5163 (13.5); 7.3672 (1.5); 7.3632 (1.6); 7.3467 (3.1); 7.3426 (3.5); 7.3366 (1.9); 7.3270 (2.3); 7.3207 (3.6); 7.3165 (3.3); 7.3089 (2.2); 7.3044 (12.7); 7.2995 (5.3); 7.2857 (16.0); 7.2835 (13.3); 7.2690 (4.2); 7.2645 (12.0); 7.2595 (1.5); 7.2069 (1.9); 7.2030 (2.0); 7.1942 (1.9); 7.1903 (2.3); 7.1870 (3.6); 7.1833 (3.8); 7.1742 (3.5); 7.1709 (3.9); 7.1666 (2.4); 7.1628 (2.3); 7.1538 (2.0); 7.1504 (2.2); 7.1247 (0.5); 7.0986 (3.6); 7.0826 (4.8); 7.0631 (2.7); 7.0569 (3.8); 7.0540 (6.0); 7.0511 (3.5); 7.0355 (9.6); 7.0199 (2.6); 7.0171 (4.4); 7.0142 (2.4); 4.7617 (5.5); 4.7220 (6.4); 4.2976 (7.0); 4.2577 (5.9); 3.9367 (1.1); 3.9255 (2.4); 3.9154 (3.2); 3.9052 (4.2); 3.8954 (3.2); 3.8852 (2.4); 3.8743 (1.1); 3.3566 (0.6); 3.3226 (130.9); 3.1676 (0.9); 2.7690 (4.9); 2.7574 (5.0); 2.7327 (6.1); 2.7211 (5.9); 2.6752 (0.8); 2.6705 (1.1); 2.6658 (0.8); 2.5448 (0.7); 2.5407 (1.2); 2.5356 (0.9); 2.5307 (0.8); 2.5240 (2.6); 2.5193 (4.1); 2.5106 (58.5); 2.5060 (126.9); 2.5014 (176.7); 2.4968 (123.5); 2.4922 (54.7); 2.4742 (0.9); 2.4643 (6.0); 2.4431 (6.2); 2.4281 (6.3); 2.4069 (8.7); 2.3879 (3.6); 2.3841 (3.3); 2.3655 (2.9); 2.3328 (1.0); 2.3280 (1.7); 2.3239 (3.5); 2.3110 (3.4); 2.3001 (4.6); 2.2871 (4.5); 2.2827 (1.9); 2.2700 (1.1); 2.2583 (2.6); 2.2462 (2.8); 2.2323 (2.1); 2.2139 (3.1); 2.2086 (1.4); 2.2018 (2.3); 2.1949 (1.9); 2.1898 (2.2); 2.1828 (3.6); 2.1778 (2.0); 2.1710 (1.2); 2.1633 (2.0); 2.1586 (2.5); 2.1393 (1.1); 2.0736 (2.2); 1.8493 (1.4); 1.8381 (2.3); 1.8269 (3.0); 1.8167 (2.5); 1.8073 (2.7); 1.7956 (2.6); 1.7844 (1.7); 1.7717 (1.1); 0.0079 (0.6); -0.0002 (21.0); -0.0085 (0.6) I.1-370:1H NMR (400.0MHz, d6-DMSO): δ= 7.2326 (0.8); 7.2139 (1.8); 7.2083 (0.9); 7.1952 (1.1); 7.1895 (0.6); 7.0805 (1.4); 7.0614 (1.1); 7.0277 (1.6); 7.0162 (1.0); 6.9972 (1.4); 4.7011 (1.0); 4.6839 (0.5); 4.6629 (1.2); 4.6455 (0.5); 4.1772 (2.4); 4.0732 (1.2); 4.0333 (7.0); 4.0056 (0.6); 3.9673 (0.5); 3.7694 (1.1); 3.7568 (1.4); 3.7470 (1.7); 3.7370 (1.8); 3.7272 (1.6); 3.6884 (0.8); 3.6696 (7.6); 3.6168 (16.0); 2.9361 (14.5); 2.8063 (0.6); 2.7967 (0.7); 2.7660 (6.1); 2.7566 (0.9); 2.5232 (1.0); 2.5185 (1.4); 2.5099 (21.0); 2.5053 (45.7); 2.5007 (63.5); 2.4961 (44.5); 2.4916 (20.3); 2.4699 (1.1); 2.4527 (0.9); 2.4295 (0.9); 2.4060 (0.6); 2.3276 (0.6); 2.2858 (12.7); 2.2650 (0.6); 2.2529 (0.7); 2.2406 (0.7); 2.1257 (0.5); 2.0935 (0.6); -0.0002 (7.9) I.1-371:1H NMR (400.0MHz, d6-DMSO): δ= 12.5439 (0.9); 8.2863 (1.7); 8.2662 (1.7); 7.2246 (1.6); 7.2209 (2.0); 7.2133 (3.2); 7.2098 (5.0); 7.2070 (6.6); 7.1950 (1.0); 7.1772 (1.2); 7.1704 (1.1); 7.1584 (1.9); 7.1510 (1.8); 7.1445 (1.2); 7.1368 (1.2); 7.1148 (2.6); 7.0968 (1.4); 4.7613 (2.3); 4.7220 (2.5); 4.2514 (0.6); 4.2367 (0.8); 4.2304 (0.9); 4.2168 (1.0); 4.2077 (0.7); 4.1931 (0.7); 4.0911 (2.1); 4.0518 (1.9); 3.7082 (0.5); 3.6963 (0.8); 3.6868 (1.0); 3.6771 (0.9); 3.6662 (0.6); 3.3163 (112.8); 3.2937 (12.0); 2.6791 (0.6); 2.6744 (1.2); 2.6698 (1.7); 2.6651 (1.2); 2.6274 (1.1); 2.6088 (3.2); 2.5902 (3.5); 2.5716 (1.5); 2.5400 (1.1); 2.5233 (4.5); 2.5186 (6.6); 2.5099 (91.1); 2.5053 (199.1); 2.5007 (277.2); 2.4961 (194.8); 2.4915 (86.8); 2.4701 (2.0); 2.4555 (0.9); 2.4506 (0.9); 2.4321 (0.6); 2.4094 (1.0); 2.3890 (1.0); 2.3674 (1.4); 2.3448 (0.8); 2.3368 (0.7); 2.3321 (1.3); 2.3275 (1.7); 2.3229 (1.3); 2.2908 (1.7); 2.2834 (1.0); 2.2693 (1.9); 2.2573 (2.0); 2.2482 (1.3); 2.2418 (1.2); 2.2350 (1.4); 2.2164 (0.8); 2.2062 (0.8); 2.0852 (1.3); 2.0731 (1.7); 2.0665 (0.7); 2.0558 (0.6); 2.0483 (1.0); 2.0341 (0.9); 2.0109 (0.8); 1.7879 (0.6); 1.7737 (0.6); 1.7648 (0.9); 1.7546 (0.9); 1.6219 (0.6); 1.6013 (0.7); 1.5861 (0.7); 1.5123 (1.4); 1.5013 (2.0); 1.4876 (2.4); 1.4788 (1.5); 1.4653 (1.2); 1.1557 (0.6); 1.1419 (6.8); 1.1232 (16.0); 1.1043 (6.6); 0.8912 (9.9); 0.8748 (9.6); 0.8232 (10.0); 0.8069 (9.7); 0.0119 (0.6); 0.0111 (0.7); 0.0103 (0.8); 0.0080 (5.0); 0.0064 (1.6); 0.0055 (1.8); 0.0047 (2.2); 0.0038 (3.0); -0.0002 (156.6); -0.0059 (1.6); -0.0067 (1.4); -0.0085 (4.4); -0.0107 (0.8); -0.0114 (0.7); -0.1496 (0.5) I.1-372:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0190 (4.2); 8.0107 (4.1); 7.3768 (1.6); 7.3555 (3.4); 7.3353 (3.5); 7.3136 (1.8); 7.2048 (2.1); 7.1887 (3.4); 7.1851 (3.6); 7.1725 (3.7); 7.1522 (1.7); 7.0668 (3.4); 7.0512 (4.6); 7.0316 (2.5); 4.7196 (5.5); 4.6795 (6.3); 4.5964 (1.8); 4.2215 (7.1); 4.1818 (6.1); 4.0942 (1.0); 4.0309 (1.0); 3.9862 (1.0); 3.8929 (1.0); 3.8003 (2.4); 3.7911 (3.8); 3.7806 (4.6); 3.7702 (3.3); 3.7593 (2.7); 3.6865 (1.2); 3.5959 (3.2); 3.5560 (2.5); 3.5425 (2.1); 3.5259 (5.2); 3.5014 (2.1); 3.4917 (8.8); 3.4842 (9.0); 3.4456 (111.1); 3.4280 (96.8); 3.3529 (39.9); 3.3315 (6.4); 3.3131 (7.5); 3.2917 (13.7); 3.2753 (18.0); 3.2549 (3.8); 3.2479 (4.7); 3.1952 (5.0); 3.1853 (3.0); 3.1696 (16.0); 3.1419 (1.6); 3.0478 (0.9); 2.8950 (0.9); 2.7713 (2.1); 2.7590 (1.5); 2.6780 (5.8); 2.6734 (8.2); 2.6688 (6.0); 2.5906 (1.9); 2.5808 (2.7); 2.5723 (5.5); 2.5624 (9.0); 2.5595 (9.7); 2.5548 (11.9); 2.5504 (5.3); 2.5433 (5.4); 2.5377 (5.8); 2.5334 (5.9); 2.5267 (19.1); 2.5220 (28.5); 2.5134 (461.3); 2.5088 (1013.8); 2.5042 (1430.8); 2.4996 (1017.2); 2.4950 (462.7); 2.4676 (3.4); 2.4605 (3.6); 2.4568 (3.3); 2.4459 (1.9); 2.4224 (6.9); 2.4106 (6.3); 2.3923 (3.1); 2.3689 (2.2); 2.3504 (4.6); 2.3402 (3.6); 2.3356 (7.2); 2.3310 (12.5); 2.3265 (9.4); 2.3079 (3.7); 2.2841 (3.3); 2.2706 (3.6); 2.2599 (4.9); 2.2470 (4.4); 2.2286 (1.9); 2.2181 (2.4); 2.2050 (2.6); 2.1468 (6.6); 2.1257 (7.8); 2.1181 (3.0); 2.1115 (6.6); 2.0984 (3.7); 2.0905 (5.7); 2.0717 (4.9); 2.0555 (1.4); 1.7468 (1.4); 1.7345 (2.2); 1.7237 (3.0); 1.7105 (2.4); 1.7019 (2.5); 1.6917 (2.8); 1.6809 (1.7); 1.6677 (1.4); 1.1413 (1.0); 1.0689 (1.0); 1.0507 (1.7); 1.0303 (2.2); 0.6097 (3.2); 0.5973 (8.5); 0.5925 (11.0); 0.5804 (10.8); 0.5746 (9.4); 0.5630 (4.3); 0.3484 (3.7); 0.3376 (10.8); 0.3311 (8.9); 0.3276 (9.6); 0.3219 (9.2); 0.3107 (3.4); 0.1460 (1.2); 0.0503 (2.1); 0.0080 (8.6); -0.0002 (340.1); -0.0085 (11.2); -0.0486 (0.9); -0.1497 (1.1) I.1-373:1H NMR (400.0MHz, d6-DMSO): δ= 8.0075 (1.3); 7.2288 (1.4); 7.2099 (3.2); 7.1912 (2.0); 7.0792 (1.9); 7.0591 (1.4); 7.0154 (2.9); 7.0027 (1.8); 6.9821 (1.3); 4.6598 (2.1); 4.6215 (2.3); 4.0119 (2.2); 3.9732 (2.0); 3.7250 (0.9); 3.7141 (1.1); 3.3164 (183.3); 3.1923 (0.8); 2.7808 (1.8); 2.6744 (1.9); 2.6696 (2.7); 2.6653 (1.8); 2.6002 (1.1); 2.5910 (0.9); 2.5820 (1.6); 2.5722 (1.9); 2.5629 (1.4); 2.5539 (1.5); 2.5384 (2.6); 2.5339 (4.0); 2.5291 (4.5); 2.5233 (8.8); 2.5185 (12.2); 2.5099 (160.8); 2.5053 (346.8); 2.5007 (479.5); 2.4961 (331.8); 2.4915 (146.3); 2.4557 (2.4); 2.4455 (1.9); 2.4213 (2.0); 2.4099 (2.0); 2.3321 (2.1); 2.3274 (3.0); 2.3226 (2.9); 2.2854 (16.0); 2.2673 (1.2); 2.2569 (1.4); 2.2434 (1.4); 2.2145 (0.7); 2.0770 (1.8); 2.0550 (1.8); 2.0426 (1.8); 2.0201 (1.9); 1.6831 (0.9); 1.6731 (0.8); 1.1752 (1.0); 1.1066 (1.3); 1.0883 (0.7); 0.8280 (0.8); 0.6104 (1.3); 0.5985 (3.1); 0.5936 (3.7); 0.5813 (3.2); 0.5756 (2.8); 0.5644 (1.0); 0.3578 (1.2); 0.3471 (3.3); 0.3405 (3.0); 0.3372 (2.8); 0.3310 (2.7); 0.3211 (0.9); 0.0080 (2.3); -0.0002 (81.5); -0.0086 (2.3) I.1-374:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.1530 (1.0); 8.1492 (0.6); 8.1394 (0.6); 8.1355 (1.0); 7.1851 (0.9); 7.1437 (0.7); 7.1395 (0.6); 6.7515 (1.0); 6.7476 (0.6); 6.7380 (0.6); 6.7340 (0.9); 3.0597 (0.9); 3.0408 (16.0); 3.0233 (2.9); 3.0052 (0.9); 2.5102 (6.6); 2.5057 (14.2); 2.5011 (19.8); 2.4965 (13.9); 2.4919 (6.2); 1.1950 (4.4); 1.1777 (4.4); 1.1695 (3.7); 1.1513 (7.6); 1.1331 (3.4); 0.8479 (1.9); 0.8306 (2.9); 0.8123 (0.6); -0.0002 (8.2) I.1-375:1H NMR (400.0 MHz, CDCl3): δ= 7.5564 (0.5); 7.5203 (2.9); 7.5147 (3.6); 7.4955 (6.1); 7.4556 (4.1); 7.4367 (8.0); 7.4166 (12.5); 7.3808 (6.6); 7.3619 (3.7); 7.3118 (0.8); 7.3013 (0.5); 7.2798 (0.9); 7.2734 (1.3); 7.2726 (1.4); 7.2710 (1.8); 7.2702 (1.9); 7.2686 (2.7); 7.2678 (3.1); 7.2615 (294.4); 7.2573 (3.3); 7.2564 (2.0); 7.2556 (1.4); 7.2548 (0.8); 7.2540 (0.6); 7.2532 (0.6); 7.1258 (1.1); 7.1163 (1.7); 7.1098 (1.6); 7.1010 (4.0); 7.0884 (3.0); 7.0860 (2.8); 7.0823 (3.2); 7.0756 (4.0); 7.0661 (2.0); 7.0621 (2.4); 7.0580 (4.6); 7.0543 (8.4); 7.0468 (12.5); 7.0442 (7.7); 7.0381 (10.8); 7.0310 (4.2); 7.0276 (5.9); 7.0160 (1.0); 7.0097 (0.7); 6.9974 (1.6); 5.4611 (2.5); 4.8482 (5.3); 4.8445 (5.1); 4.8095 (6.0); 4.8058 (5.8); 4.2384 (7.4); 4.1997 (6.6); 3.9526 (1.2); 3.9416 (2.5); 3.9308 (3.2); 3.9203 (3.6); 3.9105 (3.2); 3.8996 (2.6); 3.8885 (1.3); 3.5985 (0.8); 3.5808 (1.9); 3.5646 (3.4); 3.5467 (5.9); 3.5316 (7.1); 3.5144 (6.8); 3.4997 (5.4); 3.4825 (3.3); 3.4656 (1.7); 3.4484 (0.8); 2.9086 (0.5); 2.8906 (8.7); 2.8730 (16.0); 2.8554 (7.1); 2.6016 (5.3); 2.5908 (5.3); 2.5654 (6.2); 2.5546 (6.0); 2.5311 (1.1); 2.5120 (1.4); 2.5089 (1.3); 2.4886 (3.8); 2.4691 (3.6); 2.4657 (3.4); 2.4458 (3.4); 2.4375 (3.9); 2.4228 (4.5); 2.4133 (5.2); 2.3988 (5.3); 2.3945 (1.9); 2.3797 (1.5); 2.3701 (2.2); 2.3557 (2.1); 2.2713 (1.9); 2.2521 (3.0); 2.2474 (1.9); 2.2385 (2.4); 2.2330 (2.0); 2.2280 (2.6); 2.2195 (3.4); 2.2144 (2.2); 2.2091 (1.5); 2.2002 (2.1); 2.1951 (2.6); 2.1761 (1.4); 2.1393 (6.7); 2.1170 (6.5); 2.1031 (5.9); 2.0808 (5.7); 2.0067 (1.1); 1.8070 (1.7); 1.7956 (1.9); 1.7927 (2.2); 1.7816 (2.4); 1.7722 (2.5); 1.7689 (2.1); 1.7627 (1.9); 1.7595 (2.5); 1.7484 (2.2); 1.7393 (1.7); 1.7361 (1.5); 1.7246 (1.3); 0.0079 (2.9); 0.0062 (1.0); -0.0002 (96.0); -0.0061 (0.7); -0.0069 (0.6); -0.0085 (2.6) I.1-376:1H NMR (400.0MHz, d6-DMSO): δ= 8.2689 (0.6); 8.2555 (1.2); 8.2411 (0.6); 7.3663 (0.8); 7.3443 (0.8); 7.1964 (0.8); 7.1928 (0.9); 7.1804 (0.9); 7.1724 (0.6); 7.1601 (0.5); 7.0780 (1.0); 7.0617 (1.2); 7.0427 (0.6); 4.7388 (1.3); 4.6990 (1.5); 4.2424 (1.6); 4.2027 (1.4); 3.8203 (0.5); 3.8098 (0.7); 3.8001 (0.9); 3.7900 (0.8); 3.7797 (0.6); 3.3844 (0.9); 3.3674 (2.2); 3.3329 (82.6); 3.2829 (0.9); 3.1617 (2.1); 3.1496 (2.4); 3.1441 (2.4); 3.1327 (2.2); 3.1149 (0.9); 3.0926 (0.9); 3.0766 (1.6); 3.0639 (1.7); 2.7819 (0.7); 2.6704 (0.5); 2.5621 (1.2); 2.5509 (1.0); 2.5241 (1.5); 2.5192 (1.8); 2.5105 (30.0); 2.5060 (66.1); 2.5013 (93.4); 2.4967 (65.1); 2.4921 (29.0); 2.4555 (0.5); 2.4509 (0.6); 2.3743 (1.0); 2.3555 (0.9); 2.3327 (1.1); 2.3235 (0.5); 2.3061 (0.8); 2.2925 (0.9); 2.2819 (1.2); 2.2683 (1.2); 2.2621 (1.6); 2.2506 (0.5); 2.2404 (1.8); 2.2263 (1.6); 2.2046 (1.1); 2.1575 (0.6); 2.1450 (0.5); 2.1333 (0.6); 2.1258 (0.8); 2.1016 (0.6); 2.0733 (0.9); 1.7658 (0.5); 1.7552 (0.7); 1.7444 (0.6); 1.7339 (0.6); 1.7234 (0.6); 1.1915 (7.2); 1.1734 (16.0); 1.1552 (6.8); 1.1419 (1.1); - 0.0002 (2.7) I.1-377:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4891 (0.8); 8.4748 (1.6); 8.4603 (0.8); 7.3658 (0.8); 7.3489 (1.0); 7.3441 (1.7); 7.3274 (1.8); 7.3224 (1.0); 7.3056 (1.0); 7.2441 (1.2); 7.2377 (1.2); 7.2206 (1.3); 7.2179 (1.4); 7.2142 (1.4); 7.2115 (1.4); 7.1944 (1.2); 7.1880 (1.2); 7.1361 (2.7); 7.1162 (6.6); 7.0911 (7.5); 7.0706 (3.5); 7.0555 (1.6); 7.0529 (1.6); 7.0489 (1.4); 7.0466 (1.4); 7.0342 (0.7); 7.0315 (0.8); 7.0275 (0.6); 7.0251 (0.6); 4.6602 (2.0); 4.6223 (2.2); 4.2452 (3.6); 4.2311 (3.5); 3.9880 (2.3); 3.9498 (2.0); 3.7239 (0.8); 3.7130 (1.0); 3.7021 (1.2); 3.6927 (1.1); 3.6820 (0.9); 3.6710 (0.6); 3.6067 (1.5); 2.5755 (1.3); 2.5645 (1.3); 2.5406 (1.8); 2.5297 (1.8); 2.5251 (1.0); 2.5203 (1.3); 2.5115 (16.6); 2.5069 (36.2); 2.5023 (50.4); 2.4977 (35.2); 2.4932 (15.5); 2.3330 (1.3); 2.3136 (1.1); 2.2909 (1.0); 2.2725 (16.0); 2.2503 (1.2); 2.2400 (1.3); 2.2263 (1.3); 2.2084 (0.6); 2.1950 (1.8); 2.1846 (0.7); 2.1724 (1.7); 2.1600 (1.5); 2.1375 (1.4); 2.0414 (0.8); 2.0369 (0.6); 2.0288 (0.6); 2.0222 (0.5); 2.0173 (0.7); 2.0098 (1.0); 2.0051 (0.6); 1.9901 (0.6); 1.9856 (0.8); 1.7014 (0.6); 1.6909 (0.9); 1.6806 (0.7); 1.6693 (0.7); 1.6588 (0.7); -0.0002 (15.7) I.1-378:1H NMR (400.0MHz, d6-DMSO): δ= 10.4685 (1.8); 10.4643 (1.8); 8.0451 (0.8); 8.0308 (1.7); 8.0163 (0.8); 7.1423 (2.3); 7.1221 (7.5); 7.1181 (6.0); 7.1052 (8.3); 7.0965 (4.8); 7.0955 (4.8); 7.0846 (2.4); 7.0112 (3.0); 7.0056 (2.9); 6.8073 (3.5); 6.8015 (3.7); 6.5917 (2.5); 6.5860 (2.3); 6.5702 (2.3); 6.5644 (2.2); 4.6693 (1.9); 4.6312 (2.1); 4.0078 (2.2); 3.9697 (2.0); 3.7244 (0.8); 3.7134 (1.0); 3.7027 (1.2); 3.6932 (1.1); 3.6822 (0.9); 3.6716 (0.6); 3.5741 (2.3); 3.5187 (14.0); 3.3003 (1.0); 3.2831 (1.9); 3.2664 (1.9); 3.2490 (1.2); 3.1681 (1.0); 2.7098 (1.9); 2.6906 (2.9); 2.6732 (1.9); 2.6656 (0.7); 2.5235 (1.4); 2.5187 (2.3); 2.5101 (35.0); 2.5055 (77.3); 2.5009 (107.4); 2.4963 (75.4); 2.4917 (33.8); 2.4810 (2.2); 2.4698 (1.8); 2.3593 (0.5); 2.3555 (0.6); 2.3366 (1.4); 2.3277 (0.8); 2.3230 (0.7); 2.3179 (1.2); 2.2940 (0.9); 2.2748 (16.0); 2.2573 (1.0); 2.2436 (1.1); 2.2332 (1.3); 2.2195 (1.2); 2.2017 (0.6); 2.1914 (0.7); 2.1777 (0.6); 2.1261 (1.5); 2.1035 (1.5); 2.0915 (1.3); 2.0727 (2.7); 2.0690 (1.4); 2.0304 (0.7); 2.0181 (0.6); 2.0112 (0.5); 2.0062 (0.7); 1.9987 (0.9); 1.9941 (0.6); 1.9793 (0.6); 1.9746 (0.7); 1.6903 (0.6); 1.6795 (0.8); 1.6693 (0.7); 1.6579 (0.7); 1.6475 (0.7); -0.0002 (6.8) I.1-379:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.9122 (1.5); 8.8909 (1.6); 7.3450 (1.7); 7.3402 (2.2); 7.3259 (4.0); 7.3236 (4.0); 7.3215 (4.1); 7.3190 (3.5); 7.3082 (3.9); 7.3034 (4.5); 7.2594 (2.5); 7.2498 (8.5); 7.2428 (3.7); 7.2340 (5.6); 7.2297 (4.8); 7.2213 (1.0); 7.2173 (0.8); 7.1693 (0.5); 7.1637 (1.7); 7.1593 (1.8); 7.1546 (5.9); 7.1512 (6.9); 7.1436 (1.2); 7.1346 (1.6); 7.1244 (1.3); 7.1121 (0.6); 7.0914 (1.8); 7.0760 (1.1); 6.1043 (1.9); 6.0830 (1.8); 4.6928 (1.7); 4.6534 (1.9); 4.0259 (1.8); 3.9866 (1.6); 3.7134 (0.7); 3.7027 (0.9); 3.6918 (0.7); 3.3537 (33.4); 2.6742 (0.7); 2.6696 (1.0); 2.6650 (0.7); 2.6446 (1.0); 2.6339 (1.0); 2.6097 (1.3); 2.5993 (1.4); 2.5230 (3.0); 2.5183 (4.4); 2.5097 (56.2); 2.5051 (120.0); 2.5005 (166.7); 2.4959 (116.6); 2.4914 (51.9); 2.4550 (0.8); 2.4506 (0.8); 2.4459 (0.6); 2.3876 (0.7); 2.3733 (1.4); 2.3677 (1.0); 2.3507 (1.6); 2.3456 (1.5); 2.3386 (1.4); 2.3319 (1.0); 2.3272 (1.4); 2.3227 (1.5); 2.3164 (1.2); 2.2879 (0.7); 2.2765 (0.8); 2.2637 (1.1); 2.2524 (1.0); 2.2217 (0.6); 2.2106 (0.5); 2.1829 (16.0); 2.0852 (0.6); 2.0733 (0.6); 2.0618 (0.6); 2.0531 (0.8); 2.0301 (0.6); 1.7790 (0.5); 1.7575 (0.7); 1.7466 (0.7); 0.0080 (1.0); -0.0002 (33.6); - 0.0085 (0.9) I.1-380:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1541 (4.6); 7.1412 (2.7); 3.4508 (16.0); 3.2086 (1.9); 3.1672 (5.4); 2.7569 (2.0); 2.6697 (4.4); 2.5866 (3.4); 2.5673 (4.5); 2.5392 (6.3); 2.5347 (7.1); 2.5298 (6.3); 2.5231 (13.3); 2.5183 (20.0); 2.5097 (267.7); 2.5052 (569.6); 2.5006 (783.0); 2.4960 (547.4); 2.4915 (245.6); 2.3273 (4.9); 2.0732 (1.5); 1.1827 (3.0); 1.1637 (6.2); 1.1445 (3.7); 0.8481 (4.4); 0.8305 (5.7); 0.0080 (6.9); -0.0002 (264.6); -0.0085 (9.0); -0.1496 (1.3) I.1-381:1H NMR (400.0MHz, d6-DMSO): δ= 8.2396 (0.5); 8.2262 (1.0); 8.2127 (0.5); 7.5640 (4.2); 7.2896 (4.4); 7.2881 (4.4); 7.1391 (1.8); 7.1191 (5.1); 7.0984 (5.7); 7.0779 (1.8); 4.6597 (1.4); 4.6216 (1.6); 4.0839 (1.9); 4.0656 (9.2); 4.0509 (4.1); 4.0476 (7.0); 4.0294 (2.0); 3.9861 (1.7); 3.9481 (1.6); 3.7882 (1.2); 3.7384 (0.6); 3.7276 (0.8); 3.7167 (1.0); 3.7061 (1.0); 3.6964 (0.9); 3.6856 (0.7); 2.5167 (1.4); 2.5102 (7.3); 2.5056 (16.4); 2.5010 (21.7); 2.4963 (15.0); 2.4918 (6.6); 2.4823 (1.3); 2.4712 (1.2); 2.3326 (0.9); 2.3134 (0.8); 2.2901 (0.8); 2.2742 (11.9); 2.2596 (0.8); 2.2460 (0.9); 2.2355 (1.0); 2.2220 (1.0); 2.1936 (0.5); 2.1468 (1.3); 2.1244 (1.3); 2.1122 (1.2); 2.0898 (1.1); 2.0457 (0.6); 2.0215 (0.6); 2.0140 (0.7); 1.9898 (0.6); 1.6967 (0.7); 1.6865 (0.5); 1.6751 (0.5); 1.6647 (0.6); 1.3340 (7.2); 1.3158 (16.0); 1.2976 (7.1); -0.0002 (1.8) I.1-382:1H NMR (400.0MHz, d6-DMSO): δ= 8.2616 (0.6); 8.2474 (1.2); 8.2336 (0.6); 7.1503 (2.1); 7.1303 (6.0); 7.1100 (6.9); 7.0895 (2.2); 4.6680 (1.7); 4.6297 (1.8); 4.0313 (1.9); 3.9930 (1.7); 3.7401 (0.6); 3.7291 (0.8); 3.7180 (0.9); 3.7087 (0.8); 3.6979 (0.6); 3.3842 (0.8); 3.3680 (2.1); 3.3520 (2.6); 3.3290 (44.3); 3.1851 (0.6); 3.1560 (2.0); 3.1460 (2.4); 3.1287 (2.2); 3.0714 (1.5); 3.0592 (1.5); 3.0436 (0.7); 2.5498 (1.2); 2.5391 (1.2); 2.5236 (1.0); 2.5188 (1.6); 2.5102 (22.6); 2.5056 (49.4); 2.5010 (69.1); 2.4964 (48.3); 2.4918 (21.5); 2.3607 (1.0); 2.3419 (0.9); 2.3374 (1.0); 2.3278 (0.6); 2.3187 (0.9); 2.2909 (1.0); 2.2784 (14.4); 2.2670 (1.4); 2.2530 (1.2); 2.2250 (0.6); 2.2112 (0.6); 2.1780 (1.4); 2.1554 (1.4); 2.1425 (1.2); 2.1198 (1.3); 2.0835 (0.6); 2.0710 (0.5); 2.0594 (0.6); 2.0521 (0.8); 2.0470 (0.5); 2.0278 (0.6); 1.7189 (0.5); 1.7081 (0.7); 1.6976 (0.6); 1.6866 (0.6); 1.6759 (0.6); 1.1869 (7.2); 1.1688 (16.0); 1.1506 (6.9); -0.0002 (13.6); -0.0028 (0.7) I.1-383:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.1745 (0.5); 7.2333 (1.6); 7.2152 (2.9); 7.1961 (1.7); 7.0881 (2.0); 7.0687 (1.5); 7.0136 (4.3); 6.9921 (1.4); 4.6549 (1.7); 4.6166 (2.0); 4.0776 (1.9); 4.0386 (2.0); 3.8293 (1.8); 3.6033 (7.0); 3.5848 (6.8); 3.2132 (2.1); 3.1870 (1.3); 3.1672 (9.0); 3.1520 (2.6); 3.1376 (2.2); 3.1210 (1.1); 3.1089 (1.2); 3.0373 (1.1); 3.0254 (2.6); 2.9999 (2.2); 2.9588 (1.2); 2.9504 (1.1); 2.7659 (14.8); 2.7535 (14.4); 2.6790 (1.8); 2.6743 (3.7); 2.6697 (5.3); 2.6651 (3.9); 2.6435 (0.9); 2.5371 (2.6); 2.5321 (5.6); 2.5232 (17.4); 2.5185 (23.4); 2.5098 (273.0); 2.5053 (582.8); 2.5007 (807.5); 2.4961 (563.2); 2.4915 (248.7); 2.4662 (2.2); 2.4554 (4.0); 2.4506 (4.1); 2.4141 (1.6); 2.3948 (1.8); 2.3723 (0.8); 2.3321 (3.8); 2.3274 (5.2); 2.3228 (3.9); 2.3182 (2.1); 2.2931 (7.0); 2.2836 (16.0); 2.2479 (1.1); 2.1765 (1.0); 2.1440 (1.0); 2.1229 (0.8); 2.0732 (2.4); 1.7974 (1.2); 1.7764 (1.4); 1.7388 (0.8); 1.6943 (0.9); 1.6840 (0.8); 1.1853 (1.1); 1.0708 (5.6); 1.0528 (12.5); 1.0348 (5.4); 0.1460 (1.2); 0.0324 (0.9); 0.0080 (10.0); -0.0002 (334.8); -0.0085 (9.6); -0.0344 (1.1); -0.0504 (1.0); -0.1496 (1.2) I.1-384:1H NMR (400.0MHz, d6-DMSO): δ= 8.0053 (1.0); 7.9959 (1.0); 7.1758 (1.9); 7.1677 (8.0); 7.1629 (4.1); 7.1585 (1.2); 7.1513 (1.6); 7.1455 (0.6); 7.1387 (1.0); 7.0821 (1.4); 7.0699 (1.3); 7.0628 (0.6); 4.6886 (1.7); 4.6490 (1.9); 4.0323 (1.7); 3.9928 (1.6); 3.6967 (0.7); 3.6858 (0.9); 3.6751 (0.8); 3.3258 (7.9); 3.1848 (1.0); 3.1156 (0.5); 3.1039 (0.5); 3.0972 (0.5); 3.0859 (0.5); 2.5914 (0.6); 2.5817 (0.8); 2.5732 (1.2); 2.5634 (1.3); 2.5551 (0.8); 2.5453 (0.6); 2.5232 (0.5); 2.5185 (0.8); 2.5098 (12.2); 2.5053 (26.6); 2.5007 (36.9); 2.4961 (25.8); 2.4915 (11.6); 2.4418 (1.2); 2.4308 (1.1); 2.4070 (1.6); 2.3960 (1.3); 2.3860 (0.7); 2.3652 (0.8); 2.3442 (1.2); 2.3225 (0.8); 2.2955 (0.8); 2.2839 (1.0); 2.2714 (1.1); 2.2599 (1.0); 2.2420 (0.8); 2.2287 (16.0); 2.2184 (0.7); 2.1225 (1.5); 2.1079 (0.7); 2.1000 (1.6); 2.0876 (1.6); 2.0760 (0.8); 2.0731 (0.8); 2.0652 (1.3); 2.0526 (0.6); 1.7136 (0.8); 1.7024 (0.7); 1.1934 (1.7); 1.1752 (3.7); 1.1570 (1.7); 0.6043 (0.9); 0.5923 (2.2); 0.5870 (2.9); 0.5748 (2.8); 0.5692 (2.4); 0.5574 (1.0); 0.3484 (1.1); 0.3372 (2.6); 0.3319 (2.4); 0.3271 (2.3); 0.3220 (2.4); 0.3101 (0.9); -0.0002 (15.4) I.1-385:1H NMR (400.0MHz, CDCl3): δ= 7.2614 (11.3); 7.1099 (8.7); 6.3376 (0.9); 6.3320 (0.7); 6.3061 (2.2); 6.3005 (1.6); 4.7115 (0.6); 4.6740 (0.6); 4.1104 (0.6); 4.0729 (0.5); 3.7717 (16.0); 2.7192 (0.6); 2.7020 (1.2); 2.6848 (0.5); 2.4502 (0.7); 2.3200 (4.9); -0.0002 (3.1) I.1-387:1H NMR (400.0MHz, d6-DMSO): δ= 7.2276 (2.3); 7.2237 (2.7); 7.2141 (6.4); 7.2105 (5.7); 7.2048 (2.1); 7.1784 (1.2); 7.1714 (0.8); 7.1647 (1.8); 7.1580 (2.3); 7.1516 (1.8); 7.1447 (2.0); 7.1386 (3.0); 7.1185 (1.4); 7.0991 (0.5); 7.0770 (0.7); 5.0488 (1.4); 5.0345 (1.4); 4.8145 (1.3); 4.7999 (0.8); 4.7748 (2.5); 4.7663 (1.0); 4.7353 (1.8); 4.2880 (0.6); 4.2547 (0.6); 4.1695 (1.0); 4.1517 (1.3); 4.1358 (2.1); 4.1150 (3.0); 4.1057 (2.9); 4.1024 (3.0); 4.0972 (3.3); 4.0896 (4.3); 4.0848 (2.8); 4.0790 (1.8); 4.0720 (4.4); 4.0544 (1.2); 4.0447 (0.7); 4.0304 (0.7); 4.0062 (0.6); 3.7082 (1.2); 3.6845 (1.3); 3.3773 (33.3); 3.1659 (0.7); 3.0069 (0.6); 2.9840 (0.5); 2.9607 (0.6); 2.8572 (0.8); 2.8170 (0.9); 2.7905 (0.5); 2.7809 (0.6); 2.7504 (0.7); 2.7414 (0.6); 2.6697 (1.2); 2.6652 (0.8); 2.6183 (1.4); 2.5994 (4.4); 2.5933 (2.2); 2.5808 (4.6); 2.5749 (3.0); 2.5624 (1.9); 2.5560 (2.7); 2.5469 (1.0); 2.5400 (1.2); 2.5232 (3.4); 2.5186 (4.2); 2.5099 (66.9); 2.5053 (147.4); 2.5007 (206.9); 2.4961 (145.1); 2.4914 (64.4); 2.4596 (1.7); 2.4356 (1.9); 2.4122 (1.3); 2.3964 (1.2); 2.3738 (0.7); 2.3529 (0.7); 2.3321 (1.1); 2.3275 (1.2); 2.3227 (1.0); 2.2787 (1.0); 2.2688 (1.0); 2.2627 (0.8); 2.2546 (1.4); 2.2441 (1.2); 2.2375 (1.3); 2.2129 (0.7); 2.2028 (0.9); 2.1959 (0.7); 2.1459 (0.6); 2.1272 (1.0); 2.0768 (1.6); 2.0474 (1.1); 1.6844 (0.8); 1.5986 (1.5); 1.2184 (3.2); 1.2006 (6.0); 1.1880 (6.4); 1.1828 (4.0); 1.1807 (3.8); 1.1702 (16.0); 1.1628 (6.0); 1.1522 (14.6); 1.1450 (3.5); 1.1388 (6.2); 1.1344 (5.6); 1.1221 (12.1); 1.1201 (12.0); 1.1036 (7.8); 1.0851 (1.8); 0.0119 (0.6); 0.0111 (0.7); 0.0080 (4.9); 0.0063 (1.6); 0.0055 (1.8); 0.0047 (2.2); 0.0039 (2.8); 0.0022 (7.2); -0.0002 (154.3); -0.0027 (8.7); -0.0051 (2.0); -0.0060 (1.5); -0.0068 (1.3); -0.0085 (4.3) I.1-388:1H NMR (400.0MHz, d6-DMSO): δ= 8.3036 (1.6); 8.2987 (1.5); 8.2776 (0.7); 8.2726 (0.7); 7.7143 (1.0); 7.7080 (1.0); 7.6938 (1.6); 7.6875 (1.5); 7.6734 (0.5); 7.6672 (0.5); 7.4920 (2.0); 7.4903 (2.2); 7.4714 (1.7); 7.4698 (1.8); 4.6733 (1.0); 4.6342 (1.3); 4.6002 (0.6); 4.2092 (1.2); 4.1941 (2.3); 4.1860 (0.7); 4.1701 (1.0); 4.0410 (6.0); 3.8300 (0.6); 3.8214 (0.8); 3.8119 (0.6); 3.6737 (7.2); 3.6249 (16.0); 3.3996 (70.1); 3.1671 (1.5); 3.0144 (0.7); 2.9640 (14.4); 2.8432 (0.6); 2.8317 (0.6); 2.8026 (0.8); 2.7910 (0.8); 2.7730 (5.0); 2.6747 (1.0); 2.6701 (1.4); 2.6654 (1.0); 2.5605 (0.6); 2.5559 (1.3); 2.5513 (1.7); 2.5465 (1.5); 2.5404 (1.3); 2.5318 (0.6); 2.5235 (4.1); 2.5189 (5.0); 2.5102 (77.1); 2.5056 (169.2); 2.5010 (236.4); 2.4963 (165.7); 2.4917 (73.5); 2.4722 (0.8); 2.4674 (0.9); 2.4626 (0.7); 2.4152 (0.7); 2.3910 (0.6); 2.3819 (0.6); 2.3608 (0.5); 2.3417 (0.6); 2.3324 (1.2); 2.3277 (1.6); 2.3231 (1.2); 2.2525 (0.7); 2.2398 (0.7); 2.2005 (0.6); 2.1929 (0.7); 2.1756 (0.6); 2.1444 (0.6); 1.6346 (0.5); 0.0079 (1.3); 0.0046 (0.5); -0.0002 (49.9); -0.0085 (1.5) I.1-389:1H NMR (400.0MHz, d6-DMSO): δ= 9.5994 (14.1); 8.6430 (14.2); 8.6273 (16.0); 8.6165 (2.6); 8.2522 (5.8); 8.2321 (6.6); 8.2187 (6.9); 8.2028 (6.4); 7.8746 (4.3); 7.8593 (7.6); 7.8239 (8.6); 7.8037 (8.4); 7.7858 (4.6); 7.3755 (1.4); 7.3715 (1.5); 7.3550 (3.0); 7.3511 (3.2); 7.3451 (1.8); 7.3351 (2.3); 7.3289 (3.1); 7.3248 (2.7); 7.3087 (1.6); 7.3049 (1.6); 7.1952 (1.9); 7.1913 (2.1); 7.1824 (1.9); 7.1787 (2.4); 7.1753 (3.4); 7.1715 (3.7); 7.1624 (3.2); 7.1591 (3.7); 7.1550 (2.3); 7.1510 (2.1); 7.1421 (1.8); 7.1386 (2.0); 7.0662 (3.4); 7.0501 (4.6); 7.0308 (2.3); 4.8187 (2.0); 4.8043 (2.0); 4.7804 (5.0); 4.7659 (5.0); 4.7402 (5.1); 4.7267 (5.3); 4.7146 (5.6); 4.7024 (2.5); 4.6886 (2.4); 4.6750 (6.3); 4.2669 (2.0); 4.2195 (7.8); 4.1799 (7.0); 3.9648 (1.2); 3.8860 (1.1); 3.8516 (1.7); 3.8410 (2.7); 3.8305 (3.6); 3.8203 (4.2); 3.8101 (3.6); 3.7996 (2.7); 3.7890 (1.5); 3.6215 (0.6); 3.6027 (0.9); 3.5859 (0.8); 3.1666 (6.9); 3.1521 (0.6); 3.1341 (0.5); 3.0336 (0.7); 2.7710 (4.2); 2.7600 (3.2); 2.6799 (0.6); 2.6753 (1.3); 2.6707 (2.0); 2.6660 (1.5); 2.6614 (0.6); 2.6301 (3.8); 2.6192 (4.0); 2.5949 (4.6); 2.5839 (4.7); 2.5242 (3.7); 2.5195 (5.8); 2.5108 (103.8); 2.5062 (230.3); 2.5016 (323.4); 2.4970 (228.1); 2.4924 (102.3); 2.4219 (0.6); 2.4054 (0.8); 2.3713 (1.2); 2.3484 (1.6); 2.3286 (5.4); 2.3239 (2.3); 2.3131 (6.8); 2.2916 (6.0); 2.2782 (4.9); 2.2688 (3.2); 2.2560 (6.9); 2.2448 (4.6); 2.2315 (4.3); 2.2138 (1.4); 2.2029 (2.2); 2.1901 (2.2); 2.1517 (1.6); 2.1323 (2.6); 2.1202 (1.9); 2.1130 (1.7); 2.1085 (2.3); 2.1010 (3.1); 2.0965 (2.0); 2.0893 (1.2); 2.0811 (1.8); 2.0770 (2.3); 2.0739 (1.6); 2.0574 (1.0); 1.8103 (0.5); 1.7771 (1.4); 1.7648 (2.1); 1.7538 (2.8); 1.7434 (2.4); 1.7327 (2.4); 1.7220 (2.6); 1.7114 (1.5); 1.6983 (1.1); 1.0684 (1.7); 1.0504 (4.0); 1.0325 (1.8); 0.1460 (0.6); 0.0080 (6.2); -0.0002 (228.7); -0.0086 (6.4); -0.1494 (0.6) I.1-390:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.1681 (3.8); 7.5413 (2.6); 7.4244 (5.1); 7.3955 (8.8); 7.3769 (6.9); 7.3513 (2.8); 7.3337 (2.8); 7.2059 (11.1); 7.2022 (16.0); 7.1848 (10.3); 4.3884 (1.8); 4.3494 (2.7); 4.1620 (2.8); 4.1233 (2.1); 3.8371 (2.3); 3.4475 (3.4); 3.4047 (3.0); 3.3472 (1325.9); 3.2990 (11.7); 3.2298 (1.6); 3.1671 (7.6); 3.1053 (14.8); 2.6746 (7.0); 2.6701 (9.5); 2.6655 (6.6); 2.6060 (2.6); 2.6020 (2.8); 2.5401 (4.6); 2.5234 (27.6); 2.5186 (42.8); 2.5100 (546.6); 2.5055 (1157.8); 2.5009 (1594.9); 2.4963 (1136.1); 2.4918 (519.3); 2.4559 (10.5); 2.4517 (11.0); 2.4117 (3.0); 2.3779 (2.9); 2.3323 (8.0); 2.3277 (10.6); 2.3231 (7.6); 2.2226 (4.1); 2.1741 (2.4); 2.0731 (2.1); 2.0061 (1.8); 1.6126 (1.7); 0.0080 (7.4); -0.0002 (242.4); -0.0085 (8.1); -0.0496 (1.3) I.1-391:1H NMR (400.0MHz, d6-DMSO): δ= 8.0095 (1.2); 7.9997 (1.2); 7.1738 (2.6); 7.1533 (6.7); 7.1283 (6.4); 7.1078 (2.4); 4.6657 (1.8); 4.6276 (2.0); 3.9973 (2.0); 3.9592 (1.8); 3.7202 (0.6); 3.7093 (0.8); 3.6990 (1.0); 3.6891 (0.8); 3.6782 (0.6); 3.3160 (17.9); 2.7917 (0.6); 2.6698 (0.6); 2.6054 (1.3); 2.6001 (0.9); 2.5866 (4.0); 2.5822 (2.0); 2.5676 (4.1); 2.5481 (1.5); 2.5399 (0.6); 2.5346 (0.5); 2.5298 (0.5); 2.5233 (1.5); 2.5186 (2.2); 2.5099 (33.2); 2.5053 (72.2); 2.5007 (101.1); 2.4961 (71.3); 2.4916 (32.1); 2.4648 (1.4); 2.4534 (1.2); 2.4301 (1.6); 2.4189 (1.5); 2.3326 (1.3); 2.3276 (0.8); 2.3229 (0.6); 2.3143 (1.0); 2.2916 (0.8); 2.2657 (0.8); 2.2520 (1.0); 2.2416 (1.2); 2.2279 (1.2); 2.1997 (0.6); 2.1861 (0.6); 2.0734 (1.9); 2.0561 (0.9); 2.0512 (1.9); 2.0437 (0.7); 2.0385 (1.6); 2.0323 (0.8); 2.0246 (0.9); 2.0164 (1.5); 2.0051 (0.5); 2.0004 (0.7); 1.6865 (0.6); 1.6757 (0.8); 1.6655 (0.7); 1.6540 (0.6); 1.6436 (0.7); 1.1837 (7.1); 1.1751 (0.8); 1.1647 (16.0); 1.1457 (6.8); 0.6097 (1.0); 0.5977 (2.4); 0.5928 (3.1); 0.5808 (2.8); 0.5749 (2.5); 0.5633 (1.1); 0.3582 (1.1); 0.3474 (3.0); 0.3407 (2.7); 0.3374 (2.6); 0.3314 (2.5); 0.3212 (0.8); 0.0080 (1.6); -0.0002 (54.8); - 0.0086 (1.6) I.1-392:1H NMR (400.0MHz, d6-DMSO): δ= 8.9258 (1.0); 8.9045 (1.0); 7.3517 (0.8); 7.3494 (1.1); 7.3453 (1.1); 7.3432 (1.2); 7.3280 (2.7); 7.3228 (2.1); 7.3126 (2.9); 7.3066 (2.5); 7.2681 (3.8); 7.2571 (4.1); 7.2507 (2.9); 7.2477 (2.5); 7.2390 (2.9); 7.2314 (0.6); 7.2283 (0.6); 7.1779 (2.2); 7.1577 (3.8); 7.0996 (3.4); 7.0792 (2.0); 6.1162 (1.3); 6.0949 (1.2); 4.6735 (1.1); 4.6356 (1.2); 3.9725 (1.2); 3.9344 (1.1); 3.7317 (0.5); 3.7218 (0.6); 3.7117 (0.5); 3.3556 (12.2); 2.8645 (0.7); 2.8472 (0.9); 2.8299 (0.7); 2.6741 (0.5); 2.6693 (1.2); 2.6651 (0.6); 2.6576 (0.7); 2.6341 (0.8); 2.6231 (0.7); 2.5442 (0.7); 2.5395 (0.8); 2.5339 (0.8); 2.5230 (2.1); 2.5183 (3.0); 2.5096 (33.6); 2.5051 (71.0); 2.5004 (98.0); 2.4958 (68.0); 2.4913 (29.7); 2.4447 (0.5); 2.3405 (0.9); 2.3321 (1.0); 2.3273 (0.8); 2.3223 (0.7); 2.3182 (1.2); 2.3060 (0.9); 2.2908 (0.5); 2.2838 (0.7); 2.2471 (0.5); 2.2365 (0.6); 2.2230 (0.6); 1.1837 (16.0); 1.1664 (15.8); 0.0080 (1.0); -0.0002 (30.6); -0.0086 (0.8) I.1-393:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.1728 (8.2); 7.1553 (1.7); 7.1468 (1.2); 7.1431 (1.4); 7.1322 (1.8); 7.1182 (0.9); 7.1129 (1.0); 5.0468 (1.0); 5.0371 (1.0); 4.7629 (0.9); 4.7439 (0.6); 4.7235 (1.3); 4.7182 (1.1); 4.7102 (0.7); 4.6789 (1.2); 4.1698 (0.7); 4.1521 (0.9); 4.1359 (0.9); 4.1173 (2.0); 4.1072 (2.2); 4.1037 (1.8); 4.0991 (2.0); 4.0900 (3.8); 4.0861 (1.8); 4.0813 (1.2); 4.0724 (3.2); 4.0548 (1.4); 3.7241 (0.6); 3.7139 (0.6); 3.7040 (0.7); 3.6942 (0.7); 3.6800 (0.7); 3.6687 (0.9); 3.6606 (0.9); 3.4557 (2.5); 3.1678 (0.7); 2.8472 (0.6); 2.8377 (0.5); 2.8074 (0.7); 2.7978 (0.6); 2.7473 (0.6); 2.7386 (0.5); 2.5554 (0.6); 2.5490 (0.9); 2.5326 (0.6); 2.5233 (1.6); 2.5184 (1.9); 2.5098 (22.9); 2.5052 (48.4); 2.5006 (66.7); 2.4960 (46.0); 2.4914 (20.4); 2.4664 (0.8); 2.4606 (1.0); 2.4371 (0.7); 2.4207 (1.1); 2.3977 (0.9); 2.3272 (0.6); 2.2897 (0.5); 2.2787 (1.0); 2.2656 (0.8); 2.2543 (1.1); 2.2480 (0.9); 2.2183 (16.0); 2.2133 (6.1); 2.1989 (3.5); 2.1553 (0.5); 2.1317 (0.8); 2.1226 (0.8); 2.1118 (0.8); 2.1047 (0.8); 2.0807 (1.0); 2.0731 (1.0); 2.0424 (0.7); 1.6828 (0.6); 1.6729 (0.7); 1.6596 (0.7); 1.6499 (1.0); 1.6405 (0.9); 1.6270 (1.0); 1.6169 (1.0); 1.5949 (1.1); 1.5621 (1.0); 1.2197 (2.1); 1.2020 (4.4); 1.1892 (4.0); 1.1842 (3.0); 1.1812 (2.4); 1.1713 (10.2); 1.1633 (3.7); 1.1533 (9.9); 1.1457 (1.8); 1.1354 (3.4); 0.0080 (0.7); -0.0002 (25.0); -0.0085 (0.7) I.1-395:1H NMR (400.0MHz, d6-DMSO): δ= 7.3570 (0.9); 7.3344 (0.9); 7.1983 (0.6); 7.1903 (0.9); 7.1871 (0.9); 7.1785 (1.0); 7.1704 (0.7); 7.1667 (0.8); 7.1583 (0.5); 7.0993 (0.7); 7.0831 (0.9); 7.0642 (0.7); 4.7584 (1.3); 4.7187 (1.6); 4.2737 (1.3); 4.2341 (1.1); 4.1986 (0.7); 4.1597 (0.6); 4.0877 (2.2); 3.9436 (3.9); 3.9370 (3.8); 3.8362 (0.7); 3.8255 (0.9); 3.8158 (0.8); 3.8049 (0.6); 3.3304 (61.3); 2.9487 (16.0); 2.8403 (0.7); 2.8300 (0.7); 2.7997 (0.9); 2.7895 (1.0); 2.7633 (7.2); 2.6754 (0.6); 2.6708 (0.9); 2.6663 (0.6); 2.5293 (1.7); 2.5243 (3.2); 2.5196 (4.6); 2.5109 (49.9); 2.5064 (105.5); 2.5018 (145.5); 2.4972 (101.6); 2.4927 (44.8); 2.4726 (0.8); 2.4680 (1.1); 2.4634 (1.0); 2.4562 (1.0); 2.4513 (1.1); 2.4469 (0.9); 2.4334 (0.8); 2.4137 (0.7); 2.3999 (0.7); 2.3777 (0.6); 2.3374 (0.8); 2.3333 (0.8); 2.3286 (1.1); 2.3239 (0.8); 2.2660 (0.7); 2.2543 (0.7); 2.2416 (1.2); 2.2302 (1.1); 2.2004 (0.9); 2.1942 (1.4); 2.1795 (0.8); 2.1676 (0.6); 2.1605 (0.5); 2.1487 (0.9); 2.1286 (0.5); 2.1246 (0.6); 1.6732 (0.6); 0.0080 (1.6); -0.0002 (51.1); -0.0086 (1.4) I.1-397:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.9285 (0.7); 7.9140 (1.4); 7.8997 (0.7); 7.1445 (2.0); 7.1243 (7.4); 7.1093 (8.2); 7.0886 (2.2); 4.6685 (2.0); 4.6306 (2.2); 4.0119 (2.2); 3.9740 (2.0); 3.7161 (0.5); 3.7052 (0.9); 3.6943 (1.2); 3.6832 (1.5); 3.6743 (1.5); 3.6631 (1.5); 3.6528 (1.3); 2.8885 (1.3); 2.8713 (2.6); 2.8562 (2.7); 2.8396 (1.3); 2.5247 (0.7); 2.5200 (1.0); 2.5112 (16.1); 2.5067 (33.0); 2.5021 (46.4); 2.4975 (32.6); 2.4929 (14.4); 2.4768 (1.8); 2.4659 (1.6); 2.3430 (1.1); 2.3242 (1.1); 2.3200 (1.0); 2.3007 (0.9); 2.2755 (16.0); 2.2561 (1.2); 2.2459 (1.3); 2.2320 (1.2); 2.2143 (0.6); 2.2041 (0.6); 2.1902 (0.6); 2.1319 (1.6); 2.1093 (1.6); 2.0976 (1.4); 2.0750 (1.4); 2.0393 (0.7); 2.0348 (0.5); 2.0267 (0.6); 2.0201 (0.5); 2.0151 (0.7); 2.0078 (0.9); 2.0028 (0.6); 1.9883 (0.6); 1.9835 (0.7); 1.7026 (0.6); 1.6917 (0.9); 1.6812 (1.0); 1.6672 (1.5); 1.6595 (1.8); 1.6359 (3.6); 1.6057 (2.3); 1.3373 (0.6); 1.3285 (0.7); 1.3200 (0.6); 1.1666 (0.8); 1.1339 (1.9); 1.1093 (1.4); 0.8712 (0.6); 0.8434 (1.3); 0.8193 (1.1); -0.0002 (9.0) I.1-398:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.3034 (1.9); 8.2982 (2.0); 8.2906 (2.1); 8.2856 (2.0); 8.2727 (1.4); 8.2644 (0.9); 7.7136 (1.2); 7.7084 (2.0); 7.7026 (1.4); 7.6929 (1.9); 7.6882 (2.8); 7.6821 (1.8); 7.6752 (0.9); 7.6692 (1.3); 7.6634 (0.7); 7.4907 (5.5); 7.4836 (1.3); 7.4702 (4.6); 7.4631 (1.0); 5.0695 (0.8); 5.0600 (0.9); 5.0437 (0.9); 5.0333 (0.9); 4.6988 (1.3); 4.6603 (2.0); 4.6456 (0.6); 4.6252 (1.8); 4.6064 (0.7); 4.5869 (1.6); 4.2755 (1.9); 4.2365 (1.3); 4.2126 (2.6); 4.1731 (2.5); 4.1639 (1.5); 4.1463 (2.3); 4.1388 (1.2); 4.1291 (3.4); 4.1208 (1.6); 4.1130 (5.7); 4.1023 (1.2); 4.0953 (5.5); 4.0933 (4.3); 4.0846 (0.7); 4.0775 (1.8); 4.0754 (1.5); 3.8875 (1.2); 3.8760 (1.6); 3.8676 (2.0); 3.8562 (2.7); 3.8430 (3.1); 3.8324 (3.7); 3.8221 (4.7); 3.8020 (6.4); 3.7913 (6.9); 3.6761 (1.2); 3.1688 (0.8); 3.0576 (0.6); 3.0502 (0.8); 3.0257 (1.2); 3.0182 (1.3); 2.9932 (0.8); 2.9859 (0.7); 2.8683 (0.9); 2.8558 (0.8); 2.8418 (0.5); 2.8273 (1.3); 2.8143 (1.3); 2.7843 (1.0); 2.7732 (0.9); 2.5838 (1.0); 2.5701 (0.6); 2.5632 (1.1); 2.5504 (1.0); 2.5437 (1.0); 2.5413 (1.1); 2.5243 (1.4); 2.5199 (1.6); 2.5112 (23.8); 2.5066 (52.1); 2.5019 (72.8); 2.4973 (51.2); 2.4927 (22.9); 2.4736 (1.2); 2.4643 (0.5); 2.4531 (1.2); 2.4473 (1.0); 2.4329 (1.3); 2.4231 (1.5); 2.4131 (1.4); 2.4061 (1.5); 2.3995 (1.3); 2.3830 (1.4); 2.3659 (0.9); 2.3517 (0.6); 2.3335 (0.8); 2.3288 (0.8); 2.3167 (0.6); 2.2959 (0.5); 2.2820 (1.0); 2.2693 (1.1); 2.2576 (1.7); 2.2447 (1.7); 2.2163 (1.2); 2.2059 (1.6); 2.1892 (0.9); 2.1790 (0.8); 2.1699 (1.1); 2.1580 (1.1); 2.1485 (1.3); 2.1391 (1.2); 2.1269 (0.6); 2.1146 (1.0); 2.0953 (1.1); 2.0738 (0.7); 2.0565 (1.0); 1.6859 (0.7); 1.6754 (0.8); 1.6678 (1.0); 1.6545 (1.4); 1.6405 (2.0); 1.6334 (1.8); 1.6225 (2.2); 1.6150 (2.2); 1.6013 (2.2); 1.5818 (1.7); 1.5682 (1.4); 1.5430 (0.9); 1.5338 (0.8); 1.5283 (0.9); 1.5191 (0.8); 1.5098 (0.9); 1.4999 (0.8); 1.4949 (0.8); 1.4857 (0.6); 1.3657 (0.5); 1.2485 (0.7); 1.2376 (1.0); 1.2115 (4.4); 1.1938 (12.6); 1.1880 (4.3); 1.1843 (7.2); 1.1760 (16.0); 1.1702 (6.2); 1.1665 (12.9); 1.1583 (6.0); 1.1525 (3.1); 1.1488 (5.7); -0.0002 (3.8) I.1-399:1H NMR (400.0MHz, d6-DMSO): δ= 8.9127 (2.5); 8.8915 (2.5); 7.3674 (0.7); 7.3631 (0.7); 7.3467 (2.9); 7.3441 (4.4); 7.3407 (4.8); 7.3369 (2.2); 7.3281 (5.6); 7.3253 (7.7); 7.3223 (9.0); 7.3197 (7.9); 7.3076 (6.5); 7.3061 (6.5); 7.3040 (7.8); 7.2602 (3.9); 7.2530 (16.0); 7.2446 (5.8); 7.2358 (9.1); 7.2342 (9.0); 7.2326 (8.8); 7.2306 (7.7); 7.2179 (1.2); 7.2146 (0.5); 7.1875 (0.7); 7.1838 (0.8); 7.1749 (0.8); 7.1710 (1.0); 7.1677 (1.4); 7.1641 (1.5); 7.1547 (1.4); 7.1516 (1.6); 7.1474 (0.9); 7.1434 (0.9); 7.1345 (0.8); 7.1312 (0.8); 7.0651 (1.4); 7.0491 (2.0); 7.0298 (1.0); 6.1058 (3.1); 6.0846 (3.1); 4.7250 (2.2); 4.6854 (2.5); 4.2205 (2.7); 4.1809 (2.3); 3.8221 (0.9); 3.8116 (1.3); 3.8012 (1.5); 3.7913 (1.3); 3.7807 (0.9); 3.3166 (219.2); 3.2928 (12.2); 3.2839 (0.6); 3.2654 (0.5); 2.6706 (2.3); 2.6651 (1.1); 2.6603 (2.1); 2.6364 (2.2); 2.6253 (2.0); 2.5492 (0.5); 2.5447 (0.8); 2.5400 (1.3); 2.5351 (0.9); 2.5304 (0.9); 2.5232 (2.7); 2.5185 (4.0); 2.5098 (54.1); 2.5052 (116.7); 2.5006 (162.6); 2.4960 (113.6); 2.4914 (50.3); 2.3839 (2.4); 2.3621 (2.8); 2.3492 (2.0); 2.3387 (1.7); 2.3320 (1.2); 2.3274 (2.9); 2.3187 (1.8); 2.2966 (1.2); 2.2676 (1.1); 2.2545 (1.4); 2.2436 (1.7); 2.2306 (1.7); 2.2127 (0.6); 2.2017 (0.9); 2.1888 (0.8); 2.1244 (0.6); 2.1047 (1.0); 2.0927 (0.8); 2.0809 (1.0); 2.0730 (1.6); 2.0613 (0.5); 2.0535 (0.8); 2.0492 (1.0); 1.7908 (0.6); 1.7783 (0.8); 1.7676 (1.1); 1.7577 (1.0); 1.7461 (1.0); 1.7358 (1.0); 1.7247 (0.6); 0.0080 (0.6); -0.0002 (18.5); -0.0086 (0.5) I.1-400:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.8779 (0.6); 7.1436 (1.1); 7.1234 (4.0); 7.1083 (4.5); 7.1028 (0.9); 7.0876 (1.2); 4.6651 (1.1); 4.6271 (1.2); 4.0106 (1.2); 3.9727 (1.1); 3.7011 (0.5); 3.6903 (0.6); 3.6810 (0.5); 3.4361 (2.0); 3.0460 (0.5); 3.0423 (0.9); 3.0374 (0.6); 3.0329 (1.0); 3.0283 (0.9); 3.0234 (0.7); 3.0192 (0.9); 2.5103 (4.5); 2.5057 (10.0); 2.5011 (14.0); 2.4964 (9.9); 2.4918 (4.6); 2.4778 (0.8); 2.4545 (0.9); 2.4434 (0.8); 2.3402 (0.6); 2.3212 (0.6); 2.3176 (0.5); 2.2758 (8.8); 2.2676 (0.9); 2.2533 (0.7); 2.2431 (0.8); 2.2292 (0.8); 2.1060 (1.0); 2.0835 (1.0); 2.0717 (0.9); 2.0491 (0.9); 2.0092 (0.5); 1.5568 (0.6); 1.5400 (0.9); 1.5232 (0.8); 1.2811 (1.1); 1.2632 (2.8); 1.2456 (2.7); 1.2276 (0.9); 0.8548 (16.0); 0.8382 (15.4); -0.0002 (1.5) I.1-401:1H NMR (400.0MHz, d6-DMSO): δ= 8.0162 (0.7); 8.0064 (0.7); 7.2049 (2.1); 7.1847 (3.9); 7.1340 (3.4); 7.1136 (1.9); 4.6736 (1.2); 4.6354 (1.3); 3.9877 (1.2); 3.9495 (1.1); 3.7164 (0.5); 3.7062 (0.6); 3.6962 (0.5); 2.8773 (0.7); 2.8601 (1.0); 2.8428 (0.7); 2.5918 (0.5); 2.5833 (0.8); 2.5734 (0.8); 2.5650 (0.5); 2.5190 (0.6); 2.5103 (6.8); 2.5058 (14.6); 2.5011 (20.2); 2.4965 (14.1); 2.4920 (6.2); 2.4769 (0.8); 2.4656 (0.8); 2.4422 (0.9); 2.4309 (0.8); 2.3346 (0.6); 2.3154 (0.6); 2.2537 (0.6); 2.2433 (0.7); 2.2297 (0.7); 2.0858 (1.0); 2.0634 (1.3); 2.0509 (1.1); 2.0290 (1.1); 1.1950 (16.0); 1.1884 (1.2); 1.1777 (15.7); 1.1715 (0.9); 0.6106 (0.6); 0.5986 (1.4); 0.5937 (1.8); 0.5818 (1.7); 0.5758 (1.6); 0.5644 (0.7); 0.3592 (0.7); 0.3483 (1.9); 0.3416 (1.6); 0.3382 (1.6); 0.3323 (1.5); -0.0002 (8.8) I.1-402:1H NMR (400.0MHz, d6-DMSO): δ= 8.1670 (1.2); 8.1634 (0.6); 8.1528 (0.6); 8.1492 (1.2); 7.2025 (0.9); 7.1871 (0.5); 7.1823 (1.9); 7.1423 (1.7); 7.1219 (0.9); 6.8012 (1.2); 6.7974 (0.7); 6.7873 (0.7); 6.7833 (1.2); 4.6736 (0.6); 4.6352 (0.6); 4.0119 (0.6); 3.9737 (0.6); 3.0703 (16.0); 3.0668 (2.2); 3.0483 (1.3); 2.9434 (7.3); 2.6120 (0.9); 2.5107 (4.0); 2.5061 (8.9); 2.5015 (12.5); 2.4969 (8.9); 2.4924 (4.1); 1.1952 (7.7); 1.1779 (8.8); 1.1593 (2.9); 1.1411 (1.3); -0.0002 (4.7) I.1-409:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.1537 (0.6); 8.1400 (1.1); 8.1257 (0.6); 7.1495 (1.6); 7.1293 (5.4); 7.1138 (6.0); 7.0931 (1.6); 4.6803 (1.4); 4.6422 (1.5); 4.0201 (1.6); 3.9819 (1.4); 3.7152 (0.7); 3.7047 (0.8); 3.6947 (0.7); 3.6839 (0.5); 3.3370 (20.0); 3.1848 (0.5); 3.1414 (0.8); 3.1242 (1.7); 3.1095 (3.1); 3.0991 (2.9); 3.0925 (2.8); 3.0816 (3.1); 3.0642 (1.4); 3.0479 (0.6); 3.0200 (0.6); 3.0081 (0.9); 2.9934 (1.0); 2.9809 (0.9); 2.9696 (0.6); 2.7766 (1.1); 2.5211 (1.2); 2.5107 (11.3); 2.5062 (23.1); 2.5015 (32.3); 2.4969 (22.5); 2.4923 (10.1); 2.4868 (1.6); 2.4757 (1.2); 2.3541 (0.8); 2.3315 (0.8); 2.3118 (0.6); 2.2780 (11.7); 2.2699 (1.3); 2.2593 (1.0); 2.2453 (0.9); 2.1569 (1.2); 2.1344 (1.2); 2.1220 (1.0); 2.0994 (1.0); 2.0732 (1.2); 2.0679 (0.5); 2.0437 (0.5); 2.0364 (0.6); 2.0120 (0.5); 1.7371 (1.0); 1.7270 (1.1); 1.7167 (1.5); 1.7093 (1.3); 1.6956 (1.3); 1.6847 (0.7); 1.2137 (0.8); 1.1956 (1.8); 1.1825 (7.1); 1.1644 (16.0); 1.1462 (6.7); 1.1251 (1.2); - 0.0002 (2.0) I.1-414:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.0195 (1.8); 9.0157 (2.0); 9.0085 (2.0); 9.0047 (1.9); 8.6720 (1.2); 8.6498 (1.2); 8.5925 (0.7); 8.5779 (1.4); 8.5632 (0.7); 8.0121 (2.0); 7.9909 (2.5); 7.8176 (1.8); 7.7999 (2.2); 7.7966 (1.7); 7.7786 (1.7); 7.6990 (1.4); 7.6881 (1.4); 7.6777 (1.4); 7.6667 (1.2); 7.5966 (2.1); 7.5790 (1.8); 7.1255 (2.7); 7.1056 (6.7); 7.0832 (7.5); 7.0628 (2.6); 6.8939 (0.6); 4.8201 (0.6); 4.8057 (0.6); 4.7825 (1.5); 4.7683 (1.5); 4.7432 (1.5); 4.7294 (1.6); 4.7049 (0.6); 4.6923 (0.6); 4.6448 (1.9); 4.6069 (2.2); 3.9873 (2.6); 3.9490 (2.5); 3.7521 (4.9); 3.7414 (5.0); 3.7301 (4.9); 3.7209 (4.5); 3.7099 (3.8); 3.1660 (3.8); 2.7560 (0.5); 2.6747 (1.0); 2.6701 (1.4); 2.6654 (1.1); 2.6002 (1.3); 2.5893 (1.1); 2.5655 (1.7); 2.5548 (1.9); 2.5403 (0.9); 2.5235 (3.8); 2.5188 (5.4); 2.5102 (77.3); 2.5056 (168.9); 2.5010 (235.3); 2.4963 (164.7); 2.4917 (72.6); 2.3372 (0.9); 2.3324 (1.2); 2.3278 (1.6); 2.3229 (1.5); 2.3188 (1.6); 2.3004 (1.4); 2.2692 (16.0); 2.2552 (1.5); 2.2414 (1.3); 2.2311 (1.6); 2.2217 (2.0); 2.2175 (1.7); 2.1994 (2.1); 2.1872 (1.7); 2.1754 (0.7); 2.1644 (1.5); 2.1582 (0.7); 2.0732 (1.0); 2.0500 (0.8); 2.0377 (0.6); 2.0260 (0.8); 2.0186 (0.9); 1.9942 (0.7); 1.7034 (0.6); 1.6928 (0.9); 1.6825 (0.7); 1.6711 (0.7); 1.6610 (0.7); 0.0118 (0.6); 0.0110 (0.6); 0.0102 (0.7); 0.0079 (4.4); 0.0063 (1.5); 0.0055 (1.7); 0.0047 (2.0); 0.0038 (2.6); 0.0029 (4.1); 0.0022 (6.6); -0.0002 (144.5); -0.0027 (7.7); -0.0043 (2.8); -0.0052 (1.8); -0.0060 (1.3); -0.0068 (1.2); - 0.0085 (4.1); -0.0099 (0.8); -0.0108 (0.6); -0.0116 (0.5) I.1-415:1H NMR (400.0MHz, d6-DMSO): δ= 8.3132 (1.5); 8.3054 (1.8); 8.2939 (12.5); 8.2890 (12.9); 8.2876 (12.2); 7.9887 (4.1); 7.9787 (4.1); 7.7399 (0.8); 7.7336 (0.8); 7.7192 (1.7); 7.7130 (1.8); 7.7071 (8.0); 7.7007 (8.0); 7.6865 (9.4); 7.6802 (9.4); 7.4954 (16.0); 7.4940 (16.0); 7.4749 (13.2); 7.4734 (13.3); 5.5653 (0.6); 5.5614 (0.6); 4.8408 (0.6); 4.8245 (0.7); 4.8085 (0.6); 4.7904 (0.6); 4.6152 (9.4); 4.5761 (11.2); 4.4426 (2.0); 4.3359 (1.7); 4.3217 (1.7); 4.3118 (2.3); 4.2973 (2.2); 4.2688 (1.7); 4.1918 (10.2); 4.1526 (8.5); 3.8136 (1.4); 3.8014 (3.1); 3.7932 (3.1); 3.7813 (5.4); 3.7699 (3.2); 3.7613 (3.1); 3.7495 (1.6); 3.1671 (0.6); 2.8937 (0.5); 2.7866 (0.7); 2.7745 (0.8); 2.6758 (1.0); 2.6711 (1.3); 2.6663 (0.9); 2.6053 (1.1); 2.5951 (2.6); 2.5853 (3.6); 2.5769 (5.8); 2.5671 (6.8); 2.5573 (4.5); 2.5492 (3.7); 2.5413 (2.2); 2.5245 (2.8); 2.5199 (4.8); 2.5112 (71.5); 2.5065 (158.5); 2.5019 (222.1); 2.4973 (156.0); 2.4927 (69.1); 2.4772 (1.8); 2.4682 (6.3); 2.4558 (6.9); 2.4328 (7.4); 2.4205 (7.0); 2.3813 (1.6); 2.3642 (2.1); 2.3576 (1.9); 2.3393 (5.0); 2.3335 (2.0); 2.3288 (2.4); 2.3217 (4.6); 2.3162 (4.2); 2.2980 (4.2); 2.2843 (4.3); 2.2694 (5.0); 2.2603 (6.1); 2.2456 (5.7); 2.2276 (1.8); 2.2184 (2.9); 2.2039 (2.7); 2.1366 (2.4); 2.1177 (3.1); 2.1129 (2.2); 2.1018 (8.4); 2.0937 (3.1); 2.0863 (4.0); 2.0810 (9.7); 2.0665 (8.0); 2.0455 (6.8); 1.7135 (1.8); 1.6991 (2.5); 1.6875 (2.7); 1.6780 (2.7); 1.6670 (2.7); 1.6638 (2.3); 1.6554 (2.3); 1.6463 (1.9); 1.6316 (1.4); 0.6109 (4.2); 0.5987 (10.8); 0.5938 (14.5); 0.5816 (13.6); 0.5759 (12.3); 0.5641 (5.3); 0.5420 (0.6); 0.3911 (0.7); 0.3812 (0.7); 0.3657 (0.9); 0.3507 (5.4); 0.3394 (12.6); 0.3336 (10.8); 0.3294 (11.0); 0.3240 (10.9); 0.3130 (3.9); 0.0081 (3.1); -0.0002 (102.8); -0.0086 (2.7) I.1-417:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.2528 (0.5); 7.2263 (0.6); 7.2246 (0.6); 7.2081 (1.4); 7.1964 (0.5); 7.1901 (0.6); 7.1617 (0.7); 7.1415 (1.3); 7.1024 (0.7); 7.0869 (0.7); 7.0822 (0.5); 3.6001 (6.1); 3.1336 (1.1); 3.1216 (1.2); 3.1154 (3.7); 3.1034 (3.7); 3.0971 (3.7); 3.0851 (3.7); 3.0790 (1.2); 3.0670 (1.3); 2.5820 (0.5); 2.5626 (0.6); 2.5187 (0.8); 2.5100 (11.1); 2.5055 (24.3); 2.5008 (33.8); 2.4962 (23.8); 2.4916 (10.7); 1.1944 (7.2); 1.1762 (16.0); 1.1579 (9.1); 1.1415 (1.0); 1.1389 (1.0); -0.0002 (16.2) I.1-419:1H NMR (400.0MHz, d6-DMSO): δ= 7.2217 (2.2); 7.2088 (5.8); 7.1790 (0.8); 7.1718 (1.2); 7.1603 (1.5); 7.1523 (2.0); 7.1391 (1.5); 7.1303 (2.0); 7.1087 (0.8); 7.0884 (1.0); 7.0699 (0.6); 4.7986 (0.8); 4.7828 (1.4); 4.7599 (1.1); 4.7438 (1.6); 4.1180 (1.5); 4.0721 (3.3); 4.0547 (0.9); 4.0161 (1.0); 3.9762 (1.3); 3.9328 (3.6); 3.9195 (3.6); 3.8761 (0.5); 3.7184 (0.9); 3.5901 (0.9); 3.4810 (7.5); 3.1676 (1.4); 2.9247 (16.0); 2.8786 (1.2); 2.8372 (0.5); 2.7910 (0.9); 2.7817 (0.8); 2.7528 (7.9); 2.7270 (0.6); 2.6744 (1.1); 2.6697 (1.7); 2.6650 (1.4); 2.6240 (1.3); 2.6048 (3.0); 2.5853 (3.6); 2.5656 (2.0); 2.5232 (4.0); 2.5184 (6.3); 2.5098 (95.5); 2.5052 (207.9); 2.5006 (289.3); 2.4960 (203.2); 2.4914 (92.1); 2.4510 (1.7); 2.4438 (1.7); 2.4222 (1.0); 2.3797 (0.9); 2.3563 (1.0); 2.3323 (1.4); 2.3275 (1.8); 2.3227 (1.3); 2.2675 (0.9); 2.2572 (1.0); 2.2430 (1.3); 2.2329 (1.0); 2.2166 (0.7); 2.2017 (0.8); 2.1924 (0.7); 2.1171 (0.8); 2.0936 (0.8); 2.0859 (1.0); 2.0729 (0.7); 2.0629 (0.8); 1.6652 (0.9); 1.6568 (0.8); 1.6493 (0.6); 1.6340 (0.7); 1.1688 (0.6); 1.1538 (0.8); 1.1394 (4.5); 1.1281 (2.7); 1.1207 (10.2); 1.1095 (5.6); 1.1019 (4.6); 1.0905 (2.3); 0.0080 (2.3); -0.0002 (87.3); -0.0085 (2.8) I.1-420:1H NMR (400.0 MHz, d6-DMSO): δ= 7.4218 (1.1); 7.4038 (2.9); 7.3850 (2.4); 7.3608 (1.0); 7.3437 (0.9); 7.1807 (4.5); 7.1770 (6.3); 7.1714 (2.9); 7.1595 (4.5); 7.1508 (1.5); 7.0673 (2.3); 7.0484 (1.6); 6.8775 (2.1); 6.8541 (0.9); 4.4165 (0.8); 4.3787 (0.9); 3.9651 (0.9); 3.9264 (0.8); 3.7882 (0.9); 3.7785 (1.0); 3.7689 (0.9); 3.7582 (0.6); 3.6080 (2.0); 3.1038 (6.3); 2.5235 (1.5); 2.5188 (2.1); 2.5101 (25.4); 2.5055 (54.6); 2.5009 (75.9); 2.4963 (53.0); 2.4918 (23.7); 2.4182 (0.7); 2.3845 (0.8); 2.3277 (0.5); 2.2617 (16.0); 2.2266 (1.4); 2.2128 (1.4); 2.1208 (0.7); 2.1010 (0.8); 2.0892 (0.8); 2.0733 (1.1); 2.0321 (0.5); 2.0114 (0.6); 1.6176 (0.6); -0.0002 (15.1) I.1-421:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.1892 (1.1); 8.1860 (0.6); 8.1740 (0.6); 8.1708 (1.1); 7.2303 (0.7); 7.2116 (1.7); 7.1929 (1.0); 7.0782 (1.0); 7.0594 (0.7); 7.0246 (1.5); 7.0113 (1.0); 6.9918 (0.8); 6.8744 (1.1); 6.8710 (0.6); 6.8598 (0.6); 6.8560 (1.1); 5.3212 (1.8); 4.6616 (1.0); 4.6230 (1.1); 4.0322 (1.1); 3.9937 (1.0); 3.7446 (0.5); 3.4001 (0.6); 3.3884 (0.6); 3.3777 (0.7); 3.3692 (0.8); 3.3573 (1.1); 3.3202 (1.9); 3.2996 (1.8); 3.2634 (0.9); 3.2211 (0.7); 3.1147 (16.0); 3.1099 (5.7); 3.0895 (1.2); 3.0711 (1.2); 3.0596 (11.0); 3.0305 (0.7); 3.0155 (0.7); 3.0014 (0.6); 2.9976 (0.6); 2.9835 (0.6); 2.9304 (0.7); 2.6843 (1.7); 2.6358 (0.7); 2.6250 (0.7); 2.5986 (0.8); 2.5878 (0.8); 2.5234 (1.2); 2.5187 (1.8); 2.5100 (23.5); 2.5055 (50.2); 2.5009 (69.7); 2.4963 (49.0); 2.4917 (22.1); 2.3773 (0.6); 2.3579 (0.6); 2.3329 (0.7); 2.3276 (0.7); 2.2875 (9.1); 2.2763 (0.8); 2.2649 (0.8); 2.2539 (1.1); 2.2320 (0.9); 2.2231 (0.5); 2.2172 (0.8); 2.1948 (0.7); 2.0967 (0.5); 2.0731 (0.6); 1.1864 (0.8); 1.1682 (1.6); 1.1499 (0.8); 0.9981 (1.1); 0.9835 (0.8); 0.9801 (2.4); 0.9622 (1.1); 0.0080 (0.8); -0.0002 (27.8); -0.0086 (0.8) I.1-422:1H NMR (400.0MHz, d6-DMSO): δ= 7.2095 (2.2); 7.2052 (1.7); 7.1893 (4.3); 7.1850 (2.3); 7.1443 (3.5); 7.1238 (1.9); 7.1163 (1.6); 7.0959 (0.9); 4.6986 (1.3); 4.6605 (1.4); 4.1738 (2.4); 4.0683 (1.3); 4.0305 (5.4); 3.9855 (0.7); 3.9472 (0.5); 3.7531 (0.5); 3.7407 (0.7); 3.7308 (0.7); 3.7209 (0.5); 3.6748 (7.0); 3.6167 (15.6); 2.9250 (14.2); 2.8763 (0.9); 2.8591 (1.2); 2.8419 (0.9); 2.8028 (0.7); 2.7929 (0.7); 2.7675 (5.3); 2.7526 (0.8); 2.5190 (0.6); 2.5103 (9.4); 2.5057 (20.6); 2.5011 (28.7); 2.4965 (20.3); 2.4919 (9.3); 2.4645 (0.9); 2.4474 (0.8); 2.4243 (0.8); 2.4193 (0.6); 2.3996 (0.6); 2.3409 (0.6); 2.2518 (0.5); 2.2397 (0.7); 2.2273 (0.6); 2.0839 (0.6); 1.1957 (7.8); 1.1912 (16.0); 1.1784 (8.0); 1.1739 (15.7); -0.0002 (2.1) I.1-423:1H NMR (400.0MHz, d6-DMSO): δ= 10.6982 (0.5); 7.8200 (5.7); 7.1861 (1.8); 7.1787 (8.0); 7.1728 (3.8); 7.1640 (1.7); 7.1559 (0.9); 7.1192 (1.0); 7.1085 (0.9); 4.7434 (1.3); 4.7036 (1.4); 4.1010 (1.3); 4.0612 (1.2); 3.8091 (0.6); 3.7991 (0.6); 3.7867 (0.8); 3.7771 (0.7); 3.7667 (0.6); 3.5767 (16.0); 3.3796 (121.0); 3.1677 (1.6); 2.8463 (0.6); 2.8376 (0.6); 2.8098 (0.8); 2.7996 (0.8); 2.7669 (1.4); 2.7546 (1.4); 2.6747 (1.2); 2.6701 (1.7); 2.6655 (1.1); 2.5437 (1.7); 2.5393 (2.3); 2.5345 (2.8); 2.5297 (2.7); 2.5236 (5.2); 2.5188 (7.2); 2.5102 (92.1); 2.5056 (197.8); 2.5010 (274.6); 2.4964 (192.3); 2.4918 (86.1); 2.4752 (0.8); 2.4489 (0.9); 2.4283 (1.0); 2.4072 (0.7); 2.3507 (0.6); 2.3374 (0.9); 2.3325 (1.4); 2.3276 (2.3); 2.3233 (1.5); 2.3147 (1.0); 2.2841 (0.6); 2.2738 (0.7); 2.2408 (13.8); 2.2303 (2.4); 2.2104 (0.5); 2.1979 (0.6); 2.1901 (0.7); 2.1663 (0.5); 1.8481 (0.6); 1.8374 (0.6); 1.0646 (0.6); 1.0466 (1.4); 1.0287 (0.6); 0.0080 (1.4); -0.0002 (50.8); -0.0085 (1.5) I.1-424:1H NMR (400.0MHz, d6-DMSO): δ= 7.1788 (2.0); 7.1634 (1.4); 7.1580 (6.7); 7.1404 (6.8); 7.1198 (2.0); 4.6950 (1.8); 4.6568 (2.0); 4.0328 (1.9); 3.9947 (1.7); 3.6934 (0.6); 3.6833 (0.8); 3.6737 (0.8); 3.6703 (0.8); 3.6608 (0.8); 3.6508 (0.6); 3.3385 (1.0); 2.7050 (1.4); 2.6955 (1.4); 2.6655 (1.8); 2.6560 (1.6); 2.6066 (1.1); 2.5877 (3.6); 2.5687 (3.7); 2.5497 (1.2); 2.5105 (4.9); 2.5059 (10.8); 2.5013 (15.0); 2.4967 (10.6); 2.4921 (4.8); 2.3946 (1.0); 2.3765 (0.7); 2.3711 (0.7); 2.3532 (0.7); 2.3169 (1.8); 2.2937 (1.7); 2.2827 (0.8); 2.2775 (1.6); 2.2690 (0.9); 2.2581 (1.3); 2.2543 (1.6); 2.2445 (1.1); 2.2164 (0.7); 2.2033 (0.7); 2.1504 (0.6); 2.1380 (0.5); 2.1196 (0.7); 2.0943 (0.5); 1.7120 (0.6); 1.7008 (0.8); 1.6899 (0.6); 1.6805 (0.6); 1.6690 (0.7); 1.1828 (6.9); 1.1639 (16.0); 1.1449 (6.8); -0.0002 (0.8) I.1-425:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.2311 (1.4); 7.2273 (1.7); 7.2199 (2.5); 7.2164 (4.0); 7.2132 (5.9); 7.2011 (0.8); 7.1818 (1.1); 7.1751 (1.0); 7.1629 (1.8); 7.1555 (1.8); 7.1489 (1.0); 7.1415 (1.2); 7.1241 (2.4); 7.1061 (1.2); 4.7703 (2.2); 4.7312 (2.4); 4.0959 (2.1); 4.0568 (1.9); 3.7185 (0.5); 3.6846 (0.8); 3.6756 (1.2); 3.6661 (1.0); 3.6614 (1.0); 3.6552 (1.3); 3.6525 (1.4); 3.6466 (0.9); 3.6418 (1.0); 3.6322 (1.0); 3.6234 (0.6); 2.6804 (1.4); 2.6712 (1.5); 2.6408 (1.9); 2.6316 (1.8); 2.6248 (0.9); 2.6206 (0.9); 2.6061 (2.4); 2.6017 (2.5); 2.5871 (2.5); 2.5831 (2.7); 2.5681 (0.9); 2.5646 (1.0); 2.5109 (4.5); 2.5063 (10.0); 2.5017 (14.2); 2.4971 (10.0); 2.4925 (4.5); 2.4835 (0.5); 2.4604 (0.7); 2.4401 (1.0); 2.4194 (1.1); 2.3974 (0.7); 2.3596 (2.1); 2.3362 (2.0); 2.3200 (1.7); 2.2965 (1.8); 2.2936 (1.0); 2.2821 (0.9); 2.2685 (1.2); 2.2575 (1.2); 2.2515 (0.6); 2.2407 (0.5); 2.2267 (0.8); 2.2161 (0.8); 2.1618 (0.8); 2.1501 (0.6); 2.1372 (0.6); 2.1298 (1.0); 2.1257 (0.5); 2.1094 (0.6); 2.1053 (0.7); 2.0853 (0.6); 1.7553 (0.6); 1.7419 (0.5); 1.7333 (0.9); 1.7231 (0.9); 1.7141 (0.5); 1.1423 (6.8); 1.1235 (16.0); 1.1046 (6.7); -0.0002 (2.1) I.1-431:1H NMR (400.0MHz, CDCl3): δ= 7.5189 (11.8); 7.3098 (3.4); 7.2977 (1.7); 7.2938 (1.5); 7.2913 (1.9); 7.2866 (2.1); 7.2850 (2.2); 7.2826 (2.5); 7.2802 (3.0); 7.2786 (2.6); 7.2770 (2.9); 7.2754 (3.2); 7.2746 (3.3); 7.2738 (3.7); 7.2730 (3.9); 7.2722 (4.3); 7.2706 (6.3); 7.2699 (6.5); 7.2691 (6.7); 7.2674 (10.4); 7.2666 (12.2); 7.2650 (19.2); 7.2600 (2279.1); 7.2095 (4.8); 7.1443 (5.4); 7.1388 (2.6); 7.1309 (5.6); 7.1224 (7.5); 7.1090 (7.3); 7.0998 (3.0); 7.0827 (2.2); 7.0733 (2.5); 7.0540 (8.4); 7.0439 (5.6); 7.0403 (8.6); 7.0296 (3.9); 7.0159 (9.1); 7.0104 (3.0); 6.9959 (16.0); 6.9941 (15.8); 6.9777 (2.3); 6.9723 (6.0); 5.3388 (1.7); 4.8461 (3.4); 4.8112 (3.9); 4.2304 (5.1); 4.1914 (4.6); 3.9189 (1.5); 3.9078 (2.2); 3.8983 (2.2); 3.8877 (2.2); 3.8767 (1.6); 3.7384 (3.2); 3.5069 (2.4); 3.5019 (2.2); 3.4890 (5.4); 3.4741 (4.7); 3.4699 (5.6); 3.4564 (2.4); 3.4528 (2.3); 2.7895 (5.4); 2.7716 (10.9); 2.7542 (5.0); 2.5815 (3.7); 2.5704 (3.7); 2.5453 (4.2); 2.5345 (4.2); 2.4752 (2.6); 2.4502 (2.2); 2.4334 (2.4); 2.4206 (2.5); 2.4057 (3.0); 2.3964 (3.9); 2.3819 (3.5); 2.3534 (1.6); 2.3390 (1.8); 2.2707 (1.3); 2.2513 (2.1); 2.2379 (1.8); 2.2273 (1.7); 2.2189 (2.1); 2.2009 (4.2); 2.1943 (1.9); 2.1236 (4.5); 2.1012 (4.7); 2.0874 (4.0); 2.0650 (3.8); 1.8074 (1.4); 1.7972 (1.8); 1.7886 (1.5); 1.7745 (1.6); 1.7631 (1.4); 1.7540 (1.3); 1.5442 (113.1); 1.4634 (2.2); 1.3860 (2.2); 0.0079 (4.9); -0.0002 (178.1); -0.0085 (5.8) I.1-433:1H NMR (400.0 MHz, i.e6-DMSO): δ= 10.6262 (0.8); 8.0512 (0.7); 7.2229 (1.9); 7.2219 (1.9); 7.2012 (2.2); 7.2001 (2.2); 7.1827 (0.5); 7.1701 (0.5); 7.0787 (1.4); 7.0728 (1.5); 7.0515 (0.6); 6.9969 (1.6); 6.9908 (1.6); 6.7182 (1.2); 6.7123 (1.1); 6.6964 (1.0); 6.6905 (1.0); 4.7360 (0.7); 4.6960 (0.8); 4.2301 (0.9); 4.1903 (0.8); 3.7837 (0.5); 3.7457 (16.0); 3.3965 (17.0); 3.3117 (0.9); 3.2930 (0.9); 2.7656 (0.9); 2.7469 (1.4); 2.7290 (0.8); 2.5236 (0.5); 2.5103 (11.5); 2.5057 (25.4); 2.5011 (34.9); 2.4965 (24.5); 2.4919 (10.9); 2.4831 (1.0); 2.4713 (0.8); 2.3420 (0.5); 2.3231 (0.6); 2.2446 (0.6); 2.2313 (0.6); 2.1974 (0.8); 2.1759 (0.7); 2.1626 (0.6); 2.1411 (0.6); 2.0730 (0.7); -0.0002 (1.6) I.1-434: 1H NMR (400.0 MHz, i.e6-DMSO): δ= 11.8018 (6.5); 8.5752 (1.6); 8.3106 (16.0); 8.3089 (15.9); 8.3062 (13.2); 8.3044 (15.9); 7.7392 (3.6); 7.7329 (3.6); 7.7185 (7.5); 7.7158 (9.0); 7.7123 (8.0); 7.7095 (8.1); 7.6951 (9.5); 7.6888 (8.8); 7.5018 (14.4); 7.5003 (14.2); 7.4950 (4.5); 7.4935 (4.4); 7.4895 (7.1); 7.4879 (7.2); 7.4812 (12.4); 7.4797 (12.2); 7.4744 (3.4); 7.4730 (3.4); 7.4689 (5.4); 7.4674 (5.8); 4.8581 (0.9); 4.8394 (1.9); 4.8246 (2.4); 4.8075 (2.1); 4.7893 (0.9); 4.6424 (2.1); 4.6078 (8.1); 4.5685 (9.4); 4.3376 (0.7); 4.3109 (6.6); 4.2963 (6.9); 4.2712 (0.8); 4.2266 (2.7); 4.2161 (8.9); 4.1875 (2.2); 4.1767 (7.4); 3.9641 (3.2); 3.8599 (1.7); 3.8488 (3.1); 3.8382 (4.0); 3.8285 (4.7); 3.8186 (4.1); 3.8079 (3.3); 3.7965 (2.0); 3.7732 (1.7); 3.7622 (2.1); 3.7509 (2.4); 3.7419 (2.4); 3.7318 (2.6); 3.6391 (8.7); 3.5770 (3.7); 3.3928 (0.6); 3.2705 (0.6); 3.2206 (76.9); 3.1960 (1.4); 3.1652 (4.7); 3.0450 (0.7); 2.9093 (1.6); 2.7732 (0.8); 2.7648 (0.7); 2.7490 (4.8); 2.7379 (4.8); 2.7104 (6.2); 2.6994 (5.7); 2.6732 (3.2); 2.6702 (3.8); 2.6655 (2.6); 2.6624 (2.4); 2.6421 (0.5); 2.6039 (1.2); 2.5872 (0.8); 2.5671 (5.9); 2.5554 (7.9); 2.5491 (7.0); 2.5462 (4.1); 2.5406 (9.2); 2.5236 (7.8); 2.5191 (13.8); 2.5103 (170.6); 2.5057 (377.6); 2.5011 (530.9); 2.4965 (373.4); 2.4919 (166.5); 2.4765 (5.4); 2.4648 (4.2); 2.4587 (0.7); 2.4534 (2.8); 2.4444 (1.2); 2.4327 (2.2); 2.4279 (2.3); 2.4209 (2.4); 2.4096 (4.3); 2.4030 (2.9); 2.3928 (6.7); 2.3863 (5.0); 2.3703 (9.9); 2.3629 (4.2); 2.3541 (5.7); 2.3477 (4.1); 2.3325 (7.5); 2.3279 (5.2); 2.3233 (2.9); 2.3157 (1.6); 2.3079 (2.9); 2.3040 (3.8); 2.2986 (2.2); 2.2956 (2.8); 2.2912 (4.4); 2.2842 (2.9); 2.2804 (6.2); 2.2670 (6.2); 2.2554 (2.4); 2.2497 (1.6); 2.2433 (1.5); 2.2387 (3.0); 2.2260 (3.4); 2.2175 (1.8); 2.2100 (2.4); 2.1911 (3.2); 2.1790 (2.6); 2.1727 (2.6); 2.1672 (2.5); 2.1602 (3.6); 2.1549 (2.2); 2.1486 (1.7); 2.1414 (2.0); 2.1359 (2.2); 2.1171 (1.1); 2.0735 (0.6); 1.9304 (1.2); 1.9113 (1.2); 1.9073 (2.3); 1.8990 (1.1); 1.8882 (2.2); 1.8843 (1.2); 1.8798 (1.2); 1.8759 (1.9); 1.8652 (1.1); 1.8568 (1.8); 1.8531 (1.0); 1.8337 (0.8); 1.7547 (1.5); 1.7425 (2.7); 1.7315 (3.8); 1.7208 (3.2); 1.7116 (3.2); 1.7000 (3.1); 1.6891 (2.5); 1.6756 (1.8); 1.0471 (0.6); 0.1458 (0.8); 0.0495 (2.7); 0.0081 (8.2); -0.0002 (288.1); -0.0086 (7.9); -0.1496 (0.8) I.1-435:1H NMR (400.0MHz, d6-DMSO): δ= 8.3377 (2.2); 8.3316 (2.3); 8.3079 (0.5); 7.8272 (4.6); 7.7406 (1.4); 7.7343 (1.4); 7.7198 (1.8); 7.7136 (1.8); 7.5038 (3.0); 7.4932 (0.7); 7.4833 (2.6); 7.4727 (0.6); 4.6706 (1.3); 4.6320 (1.6); 4.2586 (1.9); 4.2194 (1.7); 3.9041 (0.8); 3.8939 (1.1); 3.8826 (1.1); 3.8738 (1.1); 3.8631 (1.0); 3.7461 (1.6); 3.6323 (1.2); 3.6007 (16.0); 3.1649 (1.0); 2.8970 (0.6); 2.8607 (0.6); 2.6700 (1.1); 2.6653 (0.8); 2.5403 (0.9); 2.5234 (2.6); 2.5188 (3.8); 2.5101 (64.9); 2.5055 (143.2); 2.5009 (200.3); 2.4963 (140.5); 2.4917 (62.7); 2.4631 (1.2); 2.4380 (1.0); 2.4133 (1.1); 2.3952 (1.1); 2.3712 (0.9); 2.3279 (1.7); 2.3146 (0.8); 2.3044 (1.0); 2.2900 (1.0); 2.2629 (0.6); 2.2497 (0.6); 2.2360 (0.5); 2.2177 (0.7); 2.1877 (0.7); 2.1693 (0.6); 1.8254 (0.6); 1.8135 (0.6); 1.7948 (0.6); 0.0079 (3.0); -0.0002 (102.0); -0.0085 (2.9) I.1-436:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.3178 (1.1); 8.3117 (1.7); 8.2956 (2.4); 8.1843 (0.5); 8.1623 (0.5); 8.1018 (0.6); 8.0803 (0.6); 8.0579 (0.6); 8.0369 (0.6); 7.7244 (0.8); 7.7179 (1.3); 7.7096 (1.0); 7.7034 (1.9); 7.6975 (1.9); 7.6892 (1.2); 7.6828 (1.2); 7.6784 (0.8); 7.4968 (3.1); 7.4764 (2.8); 4.6618 (1.0); 4.6472 (0.7); 4.6391 (0.5); 4.6230 (1.2); 4.6086 (0.8); 4.5998 (0.6); 4.3897 (0.6); 4.3784 (0.6); 4.3678 (0.6); 4.3562 (0.7); 4.3507 (0.6); 4.3391 (0.6); 4.3290 (0.6); 4.3173 (0.8); 4.2333 (0.8); 4.2128 (2.1); 4.1933 (1.2); 4.1869 (0.8); 4.1733 (2.0); 4.1651 (0.6); 3.7733 (0.9); 3.7618 (0.9); 3.3777 (8.6); 2.6705 (1.0); 2.6607 (0.6); 2.6369 (0.6); 2.6257 (0.5); 2.6034 (0.9); 2.5821 (0.6); 2.5686 (1.0); 2.5405 (0.6); 2.5238 (1.5); 2.5191 (2.3); 2.5104 (39.0); 2.5059 (86.2); 2.5012 (120.5); 2.4966 (83.7); 2.4920 (37.2); 2.3555 (0.9); 2.3496 (1.1); 2.3328 (1.6); 2.3280 (1.9); 2.3082 (1.2); 2.2936 (1.3); 2.2732 (1.9); 2.2650 (1.1); 2.2515 (1.5); 2.2377 (0.8); 2.2234 (0.5); 2.2091 (0.5); 2.0914 (0.6); 2.0784 (0.7); 2.0675 (0.8); 2.0603 (0.8); 1.8609 (0.6); 1.8430 (0.6); 1.7444 (0.9); 1.2573 (0.5); 1.2423 (0.6); 1.1631 (0.5); 1.1451 (0.6); 1.1330 (0.6); 1.1149 (0.5); 0.8502 (10.5); 0.8333 (16.0); 0.8154 (4.4); 0.0079 (1.7); -0.0002 (55.5); -0.0085 (1.6) I.1-437:1H NMR (400.0MHz, d6-DMSO): δ= 8.5763 (0.7); 8.3150 (12.6); 8.3137 (14.0); 8.3089 (13.7); 8.3074 (13.7); 8.2979 (1.1); 8.2914 (0.9); 7.7399 (1.6); 7.7337 (1.6); 7.7193 (10.2); 7.7130 (9.9); 7.6986 (10.3); 7.6923 (9.9); 7.4951 (16.0); 7.4936 (16.0); 7.4897 (3.9); 7.4880 (3.5); 7.4746 (13.6); 7.4731 (13.6); 7.4691 (3.0); 7.4675 (2.8); 7.4605 (0.6); 5.5893 (0.5); 4.8408 (0.9); 4.8255 (1.1); 4.8084 (1.0); 4.6435 (9.1); 4.6042 (11.0); 4.3379 (0.8); 4.3223 (1.0); 4.3118 (3.5); 4.2972 (3.6); 4.2723 (1.7); 4.2577 (1.5); 4.2275 (11.1); 4.1883 (9.8); 4.0855 (2.2); 3.8233 (0.6); 3.7849 (1.9); 3.7740 (3.1); 3.7631 (4.4); 3.7537 (4.5); 3.7434 (4.2); 3.7327 (3.2); 3.7216 (1.6); 3.1675 (1.0); 2.9874 (0.5); 2.9260 (0.6); 2.7131 (7.1); 2.7027 (7.3); 2.6730 (9.3); 2.6626 (8.8); 2.5682 (2.4); 2.5652 (1.2); 2.5564 (2.5); 2.5501 (2.6); 2.5415 (3.7); 2.5330 (0.7); 2.5246 (2.6); 2.5202 (5.2); 2.5112 (61.4); 2.5067 (136.8); 2.5020 (193.1); 2.4974 (137.1); 2.4928 (61.3); 2.4774 (2.3); 2.4655 (1.8); 2.4586 (0.7); 2.4541 (1.8); 2.4451 (0.8); 2.4368 (2.0); 2.4205 (2.5); 2.4107 (2.8); 2.3957 (5.3); 2.3784 (4.3); 2.3701 (12.5); 2.3566 (3.5); 2.3482 (9.3); 2.3300 (8.7); 2.3164 (1.1); 2.3082 (8.1); 2.2956 (3.9); 2.2814 (4.2); 2.2710 (6.1); 2.2571 (6.1); 2.2441 (0.9); 2.2411 (0.9); 2.2295 (3.9); 2.2181 (6.2); 2.2038 (2.7); 2.2009 (3.2); 2.1897 (3.1); 2.1846 (2.6); 2.1797 (1.6); 2.1764 (2.0); 2.1726 (3.5); 2.1654 (2.2); 2.1603 (1.6); 2.1530 (2.5); 2.1461 (2.2); 2.1286 (1.4); 1.9082 (1.0); 1.8891 (1.0); 1.8851 (0.6); 1.8807 (0.5); 1.8768 (0.8); 1.8577 (0.8); 1.7426 (1.7); 1.7327 (3.3); 1.7212 (3.7); 1.7145 (2.3); 1.7103 (2.9); 1.7036 (3.6); 1.6966 (2.2); 1.6903 (3.6); 1.6786 (2.4); 1.6650 (1.6); 0.0080 (4.2); 0.0064 (1.1); 0.0055 (1.2); 0.0047 (1.4); 0.0039 (1.9); 0.0022 (5.7); -0.0002 (148.7); -0.0026 (9.6); -0.0051 (2.7); - 0.0059 (2.0); -0.0068 (1.7); -0.0085 (4.6); -0.0107 (1.0); -0.0115 (0.9); -0.0123 (0.7); -0.0131 (0.7); - 0.0139 (0.6); -0.0147 (0.6); -0.0155 (0.5) I.1-438:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.9047 (2.5); 8.8833 (2.5); 8.2435 (4.2); 8.2384 (4.2); 7.6532 (2.7); 7.6469 (2.6); 7.6326 (3.2); 7.6263 (3.2); 7.4570 (5.4); 7.4556 (5.5); 7.4365 (4.6); 7.4351 (4.6); 7.3496 (3.0); 7.3453 (2.4); 7.3430 (3.0); 7.3393 (1.9); 7.3288 (7.4); 7.3242 (5.6); 7.3218 (6.3); 7.3129 (7.2); 7.3062 (7.0); 7.2897 (0.5); 7.2632 (12.6); 7.2551 (11.2); 7.2450 (8.9); 7.2377 (7.7); 7.2326 (4.1); 7.2269 (1.9); 7.2233 (1.5); 7.2197 (1.4); 6.1111 (3.0); 6.0899 (3.0); 4.6195 (2.8); 4.5802 (3.3); 4.1498 (3.2); 4.1108 (2.8); 3.9640 (0.7); 3.8213 (0.9); 3.8125 (1.0); 3.8013 (1.7); 3.7895 (1.1); 3.7813 (1.0); 3.5550 (2.6); 3.1653 (16.0); 2.6830 (1.8); 2.6705 (2.3); 2.6479 (2.1); 2.6358 (2.0); 2.5506 (0.6); 2.5402 (0.5); 2.5234 (1.6); 2.5187 (2.4); 2.5100 (40.0); 2.5054 (88.3); 2.5008 (123.5); 2.4962 (86.5); 2.4916 (38.4); 2.3418 (2.2); 2.3279 (2.3); 2.3209 (2.4); 2.3065 (2.9); 2.2857 (2.8); 2.2770 (1.3); 2.2622 (1.5); 2.2532 (1.7); 2.2383 (1.7); 2.2201 (0.5); 2.2115 (0.7); 2.1967 (0.7); 2.1151 (0.6); 2.0963 (0.9); 2.0833 (0.8); 2.0723 (1.0); 2.0651 (1.1); 2.0539 (0.5); 2.0408 (0.8); 1.7296 (0.8); 1.7189 (0.8); 1.7091 (0.9); 1.6977 (0.9); 1.6863 (0.8); 1.6774 (0.6); 0.0080 (1.7); -0.0002 (60.1); -0.0086 (1.6) I.1-439:1H NMR (400.0MHz, d6-DMSO): δ= 7.4189 (0.6); 7.4005 (1.5); 7.3817 (1.3); 7.3540 (0.5); 7.1708 (3.6); 7.1510 (3.3); 7.0121 (1.1); 6.9940 (0.9); 3.7781 (0.5); 3.5027 (0.9); 3.1068 (3.4); 2.8819 (0.8); 2.8645 (1.1); 2.8472 (0.9); 2.5188 (0.7); 2.5101 (11.3); 2.5056 (24.8); 2.5010 (34.7); 2.4964 (24.4); 2.4918 (11.0); 2.2013 (0.8); 2.0733 (0.9); 1.2036 (16.0); 1.1863 (15.8); -0.0002 (12.7) I.1-440:1H NMR (400.0MHz, d6-DMSO): δ= 7.2104 (2.4); 7.1902 (4.3); 7.1437 (2.8); 7.1274 (1.7); 7.1236 (1.8); 7.1067 (0.9); 5.0578 (0.6); 5.0489 (0.5); 4.7482 (0.6); 4.7106 (0.8); 4.6526 (0.6); 4.1683 (0.6); 4.1507 (0.9); 4.1332 (0.7); 4.1256 (0.5); 4.1131 (0.8); 4.1081 (1.0); 4.1059 (1.0); 4.0954 (2.5); 4.0905 (1.0); 4.0881 (0.8); 4.0776 (2.2); 4.0598 (1.1); 4.0554 (0.8); 4.0164 (1.0); 3.7391 (0.5); 3.7287 (0.6); 3.7183 (0.6); 3.7047 (0.5); 3.6945 (0.6); 3.6017 (2.4); 2.8766 (0.8); 2.8594 (1.2); 2.8426 (0.8); 2.5293 (0.5); 2.5234 (1.3); 2.5187 (1.7); 2.5100 (24.2); 2.5054 (52.9); 2.5008 (74.0); 2.4962 (52.5); 2.4917 (23.7); 2.4325 (0.7); 2.4126 (0.7); 2.3902 (0.9); 2.3728 (0.6); 2.2704 (0.6); 2.2585 (0.5); 2.2465 (0.7); 2.2341 (0.7); 2.2055 (0.5); 2.1090 (0.7); 2.0961 (0.6); 2.0850 (0.8); 2.0771 (0.9); 2.0732 (0.8); 2.0522 (0.6); 1.6416 (0.6); 1.6301 (0.7); 1.6113 (0.7); 1.5995 (0.7); 1.5880 (0.8); 1.5477 (0.6); 1.5297 (0.5); 1.2171 (1.8); 1.1993 (3.9); 1.1950 (6.2); 1.1894 (13.7); 1.1814 (3.0); 1.1778 (6.5); 1.1718 (16.0); 1.1610 (1.7); 1.1531 (6.2); 1.1432 (0.8); 1.1352 (2.4); - 0.0002 (5.3) I.1-441:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.8259 (4.8); 7.2164 (1.6); 7.1961 (4.0); 7.1678 (3.2); 7.1470 (1.4); 4.7298 (1.0); 4.6916 (1.1); 4.0565 (1.0); 4.0182 (0.9); 3.8080 (0.6); 3.5911 (12.5); 3.5066 (11.8); 3.1677 (1.5); 2.8808 (1.0); 2.8632 (1.0); 2.8460 (1.1); 2.6743 (1.0); 2.6700 (1.2); 2.6651 (0.8); 2.5232 (3.2); 2.5186 (4.8); 2.5099 (78.0); 2.5053 (170.2); 2.5007 (237.2); 2.4961 (167.3); 2.4916 (75.2); 2.4488 (0.9); 2.4311 (0.6); 2.4120 (0.7); 2.3900 (0.7); 2.3712 (0.5); 2.3320 (1.0); 2.3275 (1.4); 2.3231 (1.1); 2.3043 (0.6); 2.2938 (0.6); 2.2798 (0.7); 2.1411 (0.6); 2.0731 (0.7); 1.1946 (16.0); 1.1774 (15.7); -0.0002 (12.5) I.1-442:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.2275 (1.2); 7.2237 (1.5); 7.2181 (1.5); 7.2122 (3.8); 7.2102 (4.1); 7.1805 (0.6); 7.1734 (0.8); 7.1616 (1.0); 7.1537 (1.2); 7.1486 (0.9); 7.1403 (0.9); 7.1267 (1.4); 7.1087 (0.6); 7.0874 (0.6); 4.7820 (1.4); 4.7431 (1.6); 4.1869 (2.4); 4.1179 (1.1); 4.0789 (1.0); 4.0380 (0.6); 4.0254 (3.2); 4.0180 (3.1); 3.7118 (0.6); 3.6994 (0.5); 3.6917 (0.5); 3.6708 (7.8); 3.6113 (16.0); 3.4035 (20.6); 2.9426 (14.5); 2.8002 (0.6); 2.7913 (0.6); 2.7550 (5.7); 2.6698 (0.6); 2.6222 (0.7); 2.6034 (2.4); 2.5848 (2.9); 2.5660 (1.6); 2.5465 (1.0); 2.5401 (0.9); 2.5342 (1.3); 2.5233 (1.9); 2.5186 (2.7); 2.5100 (36.7); 2.5054 (77.7); 2.5008 (108.3); 2.4961 (76.0); 2.4915 (33.8); 2.4700 (0.9); 2.4443 (0.8); 2.4389 (0.5); 2.4223 (0.6); 2.3323 (0.5); 2.3276 (0.7); 2.3230 (0.7); 2.2598 (0.5); 2.2450 (0.7); 2.2351 (0.6); 2.0865 (0.6); 1.6615 (0.5); 1.6523 (0.6); 1.1399 (3.6); 1.1296 (1.9); 1.1211 (8.4); 1.1109 (4.0); 1.1022 (3.5); 1.0920 (1.6); -0.0002 (8.8) I.1-443:1H NMR (400.0MHz, d6-DMSO): δ= 7.1789 (1.8); 7.1716 (6.4); 7.1660 (4.5); 7.1559 (1.5); 7.1492 (1.0); 7.1425 (0.7); 7.1169 (1.0); 7.1053 (0.8); 7.0826 (0.5); 4.7268 (1.6); 4.6874 (1.8); 4.1824 (2.5); 4.0990 (1.2); 4.0596 (1.1); 4.0236 (4.0); 4.0179 (3.6); 3.9828 (0.5); 3.7116 (0.7); 3.7011 (0.6); 3.6913 (0.6); 3.6722 (7.6); 3.6117 (16.0); 3.1680 (0.6); 2.9380 (14.8); 2.7978 (0.6); 2.7884 (0.6); 2.7551 (6.0); 2.7484 (1.0); 2.5369 (1.0); 2.5334 (0.5); 2.5233 (1.1); 2.5186 (1.4); 2.5100 (14.3); 2.5054 (29.9); 2.5008 (41.2); 2.4962 (29.0); 2.4916 (12.4); 2.4726 (0.6); 2.4583 (0.6); 2.4381 (0.7); 2.3878 (0.6); 2.2704 (0.6); 2.2564 (0.8); 2.2509 (0.6); 2.2460 (0.8); 2.2396 (0.7); 2.2231 (11.0); 2.2147 (1.0); 2.2078 (5.3); 2.1474 (0.6); 2.1156 (0.6); 1.6612 (0.5); 1.6518 (0.6); 0.0080 (0.5); -0.0002 (15.7) I.1-444:1H NMR (400.0MHz, d6-DMSO): δ= 7.2065 (1.5); 7.1979 (1.4); 7.1863 (3.2); 7.1777 (2.1); 7.1451 (2.6); 7.1245 (1.4); 7.1167 (1.9); 7.0963 (1.2); 4.7035 (0.8); 4.6980 (0.9); 4.6658 (0.8); 4.6600 (1.0); 4.0717 (0.9); 4.0336 (0.9); 3.9479 (0.7); 3.9099 (0.7); 3.8923 (4.2); 3.8663 (1.4); 3.8630 (1.4); 3.7538 (0.5); 3.7437 (0.7); 3.7338 (0.7); 3.7239 (0.6); 2.9765 (0.7); 2.9673 (3.4); 2.9515 (0.7); 2.8942 (9.3); 2.8739 (1.1); 2.8565 (1.6); 2.8511 (1.6); 2.8392 (1.7); 2.8300 (3.2); 2.8124 (3.8); 2.7940 (1.3); 2.7818 (0.7); 2.7720 (1.0); 2.7483 (5.9); 2.7415 (1.0); 2.7386 (1.0); 2.7317 (0.7); 2.7101 (0.6); 2.6701 (0.6); 2.5189 (0.8); 2.5102 (13.6); 2.5056 (30.0); 2.5010 (42.0); 2.4965 (29.9); 2.4919 (13.6); 2.4545 (0.8); 2.4314 (0.8); 2.4143 (1.0); 2.3912 (0.9); 2.3122 (0.7); 2.2888 (0.5); 2.2476 (0.8); 2.2353 (0.7); 2.2230 (0.9); 2.1816 (0.5); 2.0812 (0.6); 1.1934 (10.3); 1.1907 (13.4); 1.1761 (10.3); 1.1734 (13.1); 1.0943 (7.8); 1.0762 (16.0); 1.0581 (7.6); -0.0002 (3.1) I.1-445:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.4171 (2.4); 7.3988 (5.9); 7.3801 (5.0); 7.3564 (2.1); 7.2401 (1.5); 7.2213 (4.5); 7.2010 (5.8); 7.1896 (5.8); 7.1639 (11.1); 7.1602 (16.0); 7.1549 (3.4); 7.1429 (10.7); 7.1399 (10.4); 7.1143 (3.0); 7.0964 (1.5); 6.9331 (2.0); 4.5561 (1.6); 4.5174 (1.8); 3.9547 (1.8); 3.9197 (1.5); 3.7483 (2.0); 3.3705 (0.6); 3.3514 (1.0); 3.3187 (341.0); 3.2683 (1.4); 3.1666 (2.2); 3.0888 (11.4); 2.6747 (1.3); 2.6700 (1.9); 2.6654 (1.4); 2.6608 (0.7); 2.5516 (1.3); 2.5235 (6.4); 2.5187 (8.8); 2.5100 (111.3); 2.5055 (243.2); 2.5008 (342.2); 2.4962 (239.3); 2.4916 (106.5); 2.4501 (1.4); 2.3836 (1.3); 2.3324 (2.6); 2.3277 (2.6); 2.3232 (2.0); 2.2184 (3.2); 2.1778 (1.0); 2.1225 (1.7); 2.0910 (2.6); 2.0730 (3.3); 1.6739 (1.4); 1.2341 (0.6); 1.0961 (6.9); 1.0775 (13.3); 1.0586 (6.4); 0.0080 (0.7); -0.0002 (24.2); -0.0086 (0.7) I.1-446:1H NMR (400.0MHz, d6-DMSO): δ= 7.8292 (6.0); 7.1878 (0.8); 7.1662 (8.0); 7.1616 (7.5); 7.1398 (0.9); 7.1343 (0.7); 4.7234 (1.3); 4.6851 (1.4); 4.1054 (0.6); 4.0669 (1.9); 4.0486 (0.8); 4.0287 (1.9); 4.0109 (0.8); 3.8244 (0.6); 3.8138 (0.8); 3.8023 (0.8); 3.7924 (0.8); 3.7819 (0.6); 3.5916 (16.0); 3.1119 (0.6); 2.8740 (0.5); 2.8640 (0.6); 2.8369 (0.7); 2.8271 (0.6); 2.7697 (1.1); 2.7573 (1.1); 2.6083 (1.1); 2.5893 (3.5); 2.5703 (3.6); 2.5516 (1.3); 2.5236 (0.6); 2.5189 (1.0); 2.5103 (15.8); 2.5057 (34.8); 2.5011 (49.1); 2.4965 (35.0); 2.4919 (16.0); 2.4760 (1.0); 2.4679 (0.8); 2.4628 (0.9); 2.4377 (0.7); 2.4321 (0.5); 2.4132 (0.8); 2.3945 (0.7); 2.3902 (0.7); 2.3713 (0.6); 2.3171 (0.5); 2.3036 (0.6); 2.2926 (0.8); 2.2793 (0.8); 2.1665 (0.5); 2.1350 (0.6); 1.8130 (0.5); 1.8023 (0.5); 1.7921 (0.5); 1.1833 (5.8); 1.1644 (13.0); 1.1454 (5.7); 1.0511 (0.9); -0.0002 (4.4) I.1-447:1H NMR (400.0 MHz, d6-DMSO): δ= 7.2344 (1.4); 7.2155 (3.5); 7.1969 (2.3); 7.0832 (2.0); 7.0644 (1.6); 7.0317 (2.1); 7.0145 (1.9); 6.9963 (1.9); 5.0649 (1.0); 5.0571 (1.0); 5.0501 (1.0); 4.7558 (1.0); 4.7175 (1.4); 4.7097 (1.4); 4.6712 (1.7); 4.1706 (0.7); 4.1526 (1.1); 4.1347 (0.9); 4.1252 (1.0); 4.1175 (0.9); 4.1107 (2.0); 4.1075 (2.8); 4.0997 (0.9); 4.0950 (3.2); 4.0898 (2.8); 4.0824 (1.3); 4.0774 (3.1); 4.0722 (0.9); 4.0596 (1.0); 4.0473 (1.2); 4.0075 (1.0); 3.9682 (0.8); 3.7471 (0.7); 3.7419 (0.7); 3.7330 (0.7); 3.7281 (0.7); 3.7188 (0.8); 3.7093 (0.8); 3.6996 (0.6); 3.6719 (0.7); 3.4407 (6.2); 2.8714 (0.7); 2.8617 (0.7); 2.8315 (0.9); 2.8216 (0.9); 2.7779 (0.6); 2.7683 (0.6); 2.6698 (0.6); 2.5287 (1.0); 2.5233 (1.9); 2.5185 (2.6); 2.5099 (32.9); 2.5053 (71.3); 2.5007 (99.0); 2.4961 (69.4); 2.4915 (31.1); 2.4801 (1.0); 2.4644 (1.1); 2.4611 (1.2); 2.4561 (1.3); 2.4514 (1.1); 2.4464 (0.8); 2.4412 (0.9); 2.4208 (1.4); 2.3974 (1.6); 2.3811 (1.2); 2.3582 (0.8); 2.3274 (0.8); 2.3228 (0.6); 2.2856 (16.0); 2.2705 (1.2); 2.2586 (1.3); 2.2460 (1.3); 2.2409 (0.9); 2.2289 (0.6); 2.2166 (0.9); 2.2044 (0.7); 2.1337 (1.0); 2.1207 (0.6); 2.1144 (1.0); 2.1093 (0.9); 2.1013 (1.2); 2.0904 (1.3); 2.0822 (1.3); 2.0731 (1.0); 2.0576 (1.0); 1.6466 (0.9); 1.6382 (1.2); 1.6252 (1.4); 1.6146 (1.4); 1.6074 (1.2); 1.5938 (1.4); 1.5688 (1.1); 1.5448 (0.8); 1.5361 (0.8); 1.5206 (0.5); 1.5019 (0.6); 1.4868 (0.6); 1.2178 (2.3); 1.2000 (4.2); 1.1916 (4.6); 1.1822 (2.8); 1.1794 (2.6); 1.1738 (8.7); 1.1709 (4.4); 1.1616 (3.9); 1.1561 (4.5); 1.1531 (7.7); 1.1439 (1.9); 1.1353 (3.2); 0.0080 (0.6); -0.0002 (22.4); -0.0085 (0.6) I.1-515:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.2755 (0.7); 8.2547 (1.7); 8.2341 (1.2); 7.1741 (2.3); 7.1533 (8.3); 7.1384 (5.8); 7.1340 (4.1); 7.1179 (1.8); 4.6778 (2.0); 4.6398 (2.2); 4.2019 (0.7); 4.1875 (0.8); 4.1641 (0.6); 4.1440 (0.5); 4.0525 (0.8); 4.0175 (1.7); 3.9805 (1.2); 3.7054 (0.7); 3.6946 (0.9); 3.6856 (0.8); 3.3875 (14.2); 3.1680 (1.2); 2.6743 (1.1); 2.6698 (1.5); 2.6651 (1.1); 2.6057 (1.6); 2.5868 (5.1); 2.5682 (4.6); 2.5493 (2.4); 2.5399 (2.2); 2.5296 (1.9); 2.5232 (4.2); 2.5185 (6.0); 2.5099 (90.2); 2.5053 (196.6); 2.5006 (273.5); 2.4960 (191.2); 2.4914 (85.2); 2.3547 (0.8); 2.3322 (1.9); 2.3275 (2.0); 2.2726 (0.6); 2.2597 (0.8); 2.2482 (0.9); 2.2289 (1.0); 2.2182 (0.6); 2.2064 (1.1); 2.1940 (1.0); 2.1864 (1.0); 2.1713 (0.6); 2.1627 (1.0); 2.1516 (0.8); 2.1285 (0.8); 2.0064 (0.7); 1.9974 (0.7); 1.7569 (0.5); 1.7352 (0.6); 1.7248 (0.5); 1.6004 (0.7); 1.5127 (1.3); 1.5007 (2.0); 1.4875 (1.9); 1.4763 (1.4); 1.4652 (1.0); 1.1836 (7.2); 1.1645 (16.0); 1.1457 (6.8); 0.8936 (7.4); 0.8772 (7.2); 0.8287 (6.7); 0.8125 (6.6); 0.0335 (0.6); 0.0080 (4.4); 0.0064 (1.5); 0.0056 (1.8); 0.0048 (2.0); 0.0039 (2.6); -0.0002 (142.0); -0.0059 (1.7); -0.0067 (1.4); -0.0085 (4.0) I.1-516:1H NMR (400.0MHz, d6-DMSO): δ= 12.5667 (0.9); 8.1997 (0.8); 8.1777 (0.8); 8.1480 (1.7); 8.1270 (1.8); 7.2257 (1.9); 7.2206 (2.9); 7.2115 (5.4); 7.2070 (7.8); 7.1952 (1.2); 7.1722 (1.0); 7.1669 (0.9); 7.1534 (2.4); 7.1464 (2.5); 7.1408 (2.3); 7.1364 (4.1); 7.1335 (3.6); 7.1189 (1.8); 7.1008 (0.6); 4.7684 (2.7); 4.7292 (3.0); 4.2250 (0.8); 4.2102 (0.8); 4.2035 (0.8); 4.1888 (0.8); 4.1555 (1.6); 4.1406 (1.7); 4.1347 (1.7); 4.1198 (1.6); 4.0849 (1.0); 4.0611 (2.1); 4.0458 (0.9); 4.0222 (1.9); 3.6785 (0.8); 3.6686 (0.9); 3.6583 (0.9); 3.6481 (1.1); 3.6269 (0.6); 3.3176 (97.6); 2.6744 (0.9); 2.6697 (1.3); 2.6652 (1.0); 2.6253 (1.5); 2.6091 (4.8); 2.6059 (4.6); 2.5900 (4.4); 2.5873 (4.6); 2.5771 (1.8); 2.5681 (2.7); 2.5502 (0.8); 2.5402 (1.2); 2.5233 (4.1); 2.5185 (6.3); 2.5099 (74.0); 2.5053 (158.8); 2.5007 (219.4); 2.4961 (153.2); 2.4915 (68.3); 2.4450 (0.8); 2.4227 (1.0); 2.4004 (1.0); 2.3807 (1.6); 2.3759 (1.7); 2.3540 (1.2); 2.3416 (0.7); 2.3366 (0.7); 2.3321 (1.1); 2.3275 (1.4); 2.3228 (1.2); 2.3191 (1.0); 2.3127 (1.6); 2.2890 (1.7); 2.2784 (1.9); 2.2615 (1.3); 2.2550 (1.9); 2.2452 (0.9); 2.2337 (0.7); 2.2194 (0.7); 2.2099 (0.7); 2.0607 (0.6); 2.0397 (0.9); 2.0063 (1.0); 1.9840 (0.8); 1.8404 (0.5); 1.8308 (0.8); 1.8082 (1.1); 1.7983 (1.2); 1.7901 (0.8); 1.7758 (1.2); 1.7674 (1.3); 1.7571 (1.0); 1.7459 (1.1); 1.7297 (0.8); 1.4077 (0.7); 1.4002 (0.6); 1.3891 (0.9); 1.3849 (0.8); 1.3739 (1.0); 1.3663 (0.8); 1.3553 (0.8); 1.2098 (0.8); 1.1914 (1.1); 1.1690 (1.0); 1.1533 (1.0); 1.1431 (7.2); 1.1401 (5.0); 1.1244 (16.0); 1.1213 (10.0); 1.1055 (6.9); 1.1025 (4.3); 0.8565 (5.3); 0.8468 (12.6); 0.8382 (11.8); 0.8298 (15.0); 0.8196 (4.5); 0.8122 (2.5); 0.0081 (2.4); -0.0002 (82.4); -0.0085 (2.4) I.1-517:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.9552 (2.6); 8.5539 (0.9); 8.5332 (0.9); 7.3878 (2.5); 7.1400 (1.9); 7.1201 (4.5); 7.0942 (4.8); 7.0738 (1.9); 4.6568 (0.6); 4.6370 (1.8); 4.6234 (0.6); 4.5996 (1.4); 3.9779 (1.2); 3.9399 (1.3); 3.6394 (16.0); 3.6289 (3.0); 3.3504 (22.2); 3.1613 (0.6); 3.1491 (0.7); 3.1240 (0.9); 3.1111 (0.9); 2.9957 (0.9); 2.9716 (0.8); 2.9584 (0.7); 2.9338 (0.6); 2.6737 (0.6); 2.6691 (0.9); 2.6645 (0.6); 2.5393 (0.5); 2.5335 (0.9); 2.5226 (2.9); 2.5178 (3.3); 2.5092 (49.5); 2.5046 (107.9); 2.5000 (151.2); 2.4954 (104.4); 2.4908 (47.0); 2.3314 (0.8); 2.3268 (1.1); 2.3222 (0.9); 2.3010 (0.8); 2.2736 (11.2); 2.2596 (0.7); 2.2438 (0.6); 2.2297 (0.7); 2.2198 (0.8); 2.2056 (0.8); 2.1635 (1.2); 2.1415 (0.8); 2.1280 (0.7); 2.1065 (0.7); 0.0080 (1.2); - 0.0002 (41.8); -0.0085 (1.2) I.1-518:1H NMR (400.0MHz, d6-DMSO): δ= 8.3453 (1.8); 8.3245 (1.9); 7.7051 (0.6); 7.2609 (1.0); 7.2576 (1.2); 7.2436 (2.1); 7.2403 (3.0); 7.2363 (3.1); 7.2217 (8.2); 7.2154 (8.0); 7.2029 (3.3); 7.1993 (3.7); 7.1819 (2.2); 7.1730 (0.6); 7.1658 (0.7); 7.1265 (3.6); 7.1069 (6.4); 7.0805 (1.0); 7.0565 (6.5); 7.0364 (3.6); 4.5962 (2.0); 4.5584 (2.1); 4.4474 (0.7); 4.4355 (0.8); 4.4216 (1.1); 4.4148 (1.0); 4.4013 (0.9); 4.3894 (0.7); 3.8739 (2.1); 3.8360 (2.0); 3.5738 (0.7); 3.5632 (1.0); 3.5532 (1.4); 3.5431 (1.0); 3.5314 (0.8); 3.4204 (4.2); 3.1645 (0.7); 3.0876 (1.1); 3.0761 (1.2); 3.0529 (1.5); 3.0418 (1.3); 2.8341 (1.4); 2.8086 (1.5); 2.7994 (1.3); 2.7742 (1.2); 2.6697 (1.0); 2.6650 (0.7); 2.5401 (0.6); 2.5231 (0.9); 2.5185 (2.3); 2.5098 (53.5); 2.5052 (119.7); 2.5006 (168.6); 2.4960 (118.5); 2.4914 (53.6); 2.4791 (3.0); 2.4724 (2.3); 2.4681 (2.8); 2.4451 (1.8); 2.4346 (1.5); 2.3321 (0.7); 2.3275 (1.0); 2.3226 (0.7); 2.2708 (16.0); 2.2529 (1.4); 2.2324 (1.4); 2.2097 (0.9); 2.1844 (0.9); 2.1714 (1.2); 2.1605 (1.3); 2.1473 (1.2); 2.1239 (1.6); 2.1010 (1.6); 2.0899 (1.4); 2.0669 (1.3); 1.8759 (0.6); 1.8641 (0.6); 1.8520 (0.7); 1.8441 (0.9); 1.8200 (0.8); 1.6448 (0.6); 1.6339 (0.9); 1.6243 (0.8); 1.6121 (0.8); 1.6018 (0.7); 0.0080 (1.3); -0.0002 (40.8); -0.0085 (1.1) I.1-519:1H NMR (400.0MHz, d6-DMSO): δ= 7.3565 (1.0); 7.3349 (1.0); 7.1982 (0.6); 7.1870 (1.0); 7.1782 (1.0); 7.1702 (0.8); 7.1667 (0.8); 7.1581 (0.6); 7.0990 (0.7); 7.0828 (1.0); 7.0640 (0.8); 7.0508 (0.5); 4.7582 (1.4); 4.7182 (1.6); 4.2737 (1.3); 4.2339 (1.2); 4.1995 (0.7); 4.1596 (0.6); 4.0870 (2.3); 3.9436 (4.0); 3.9370 (3.9); 3.8356 (0.8); 3.8262 (0.9); 3.8157 (0.9); 3.8054 (0.7); 3.3316 (54.4); 2.9487 (16.0); 2.8403 (0.8); 2.8298 (0.8); 2.7997 (1.0); 2.7894 (1.0); 2.7633 (7.3); 2.6755 (0.6); 2.6709 (0.9); 2.6663 (0.6); 2.6555 (0.5); 2.6453 (0.6); 2.5533 (0.9); 2.5409 (0.7); 2.5363 (0.9); 2.5311 (1.4); 2.5243 (2.1); 2.5196 (3.4); 2.5109 (46.9); 2.5064 (99.8); 2.5018 (138.4); 2.4972 (98.6); 2.4927 (45.2); 2.4698 (0.8); 2.4560 (0.8); 2.4515 (0.8); 2.4330 (0.8); 2.4119 (0.7); 2.3994 (0.7); 2.3773 (0.6); 2.3333 (0.8); 2.3286 (1.0); 2.3240 (0.8); 2.2658 (0.7); 2.2542 (0.7); 2.2416 (1.2); 2.2299 (1.1); 2.2002 (1.0); 2.1942 (1.4); 2.1793 (0.9); 2.1676 (0.7); 2.1609 (0.6); 2.1485 (1.0); 2.1244 (0.6); 1.6949 (0.5); 1.6727 (0.6); 1.6556 (0.5); 0.0080 (1.3); -0.0002 (43.1); -0.0085 (1.4) I.1-522:1H NMR (400.0 MHz, CDCl3): δ= 7.3270 (0.8); 7.3239 (1.5); 7.3198 (0.6); 7.3111 (0.9); 7.3065 (3.6); 7.3029 (2.0); 7.2913 (1.3); 7.2879 (3.0); 7.2825 (0.6); 7.2666 (0.6); 7.2658 (0.7); 7.2650 (0.9); 7.2603 (62.9); 7.2553 (1.1); 7.2534 (1.8); 7.2497 (1.0); 7.2408 (0.5); 7.2349 (1.7); 7.2166 (0.6); 7.1601 (2.4); 7.1563 (3.4); 7.1510 (0.8); 7.1395 (2.4); 7.1383 (2.3); 7.1364 (1.9); 7.1096 (28.3); 5.2981 (1.1); 5.2743 (0.5); 4.7065 (1.8); 4.6690 (2.0); 4.1086 (1.8); 4.0711 (1.6); 3.9313 (0.7); 3.9209 (0.7); 3.9108 (1.1); 3.9007 (0.7); 3.8901 (0.7); 3.5138 (0.8); 3.4962 (1.3); 3.4810 (1.3); 3.4788 (1.2); 3.4638 (1.2); 3.4615 (1.3); 3.4467 (1.2); 3.4296 (0.8); 2.7830 (2.0); 2.7657 (4.0); 2.7484 (1.8); 2.4840 (1.3); 2.4725 (1.3); 2.4562 (0.9); 2.4480 (1.5); 2.4366 (2.2); 2.4139 (0.7); 2.4052 (0.9); 2.3908 (1.0); 2.3810 (1.2); 2.3668 (1.2); 2.3383 (0.6); 2.3221 (16.0); 2.1924 (0.7); 2.1792 (0.5); 2.1683 (0.6); 2.1600 (0.8); 2.1551 (0.5); 2.1356 (0.7); 2.0491 (1.5); 2.0277 (1.5); 2.0131 (1.3); 1.9916 (1.3); 1.7359 (0.5); 1.7252 (0.6); 1.7155 (0.6); 1.7028 (0.6); 1.6920 (0.5); 1.5819 (0.8); 0.0079 (0.5); -0.0002 (18.4); -0.0085 (0.5) I.1-525:1H NMR (400.0MHz, d6-DMSO): δ= 8.4851 (2.4); 8.4751 (3.2); 8.0299 (2.2); 7.7108 (1.2); 7.6921 (2.4); 7.6763 (1.5); 7.2369 (3.1); 7.2313 (3.1); 7.2188 (4.7); 7.1385 (2.7); 7.1195 (7.1); 7.0959 (7.0); 7.0770 (3.8); 4.6431 (2.2); 4.6051 (2.4); 3.9711 (2.5); 3.9326 (2.3); 3.9028 (2.2); 3.8912 (1.0); 3.6766 (0.8); 3.6666 (1.4); 3.6557 (1.8); 3.6462 (1.8); 3.6367 (1.4); 3.4924 (0.4); 3.4823 (0.3); 3.3991 (3.4); 3.3851 (4.3); 3.3739 (3.4); 3.3322 (138.2); 3.1656 (0.4); 2.8554 (2.8); 2.8375 (5.6); 2.8205 (3.2); 2.6670 (1.1); 2.5019 (178.1); 2.4981 (194.3); 2.4411 (2.0); 2.4306 (2.5); 2.3519 (0.5); 2.3290 (1.8); 2.3252 (1.9); 2.3123 (1.8); 2.2892 (2.0); 2.2737 (16.0); 2.2438 (1.3); 2.2302 (1.4); 2.2198 (1.7); 2.2031 (1.6); 2.1894 (0.9); 2.1786 (0.8); 2.1643 (0.8); 2.0878 (1.4); 2.0648 (1.6); 2.0533 (2.0); 2.0307 (1.3); 2.0069 (0.5); 1.9842 (0.9); 1.9749 (1.0); 1.9636 (1.2); 1.9533 (1.4); 1.9320 (1.2); 1.9128 (0.5); 1.6508 (0.4); 1.6381 (0.9); 1.6279 (1.2); 1.6157 (1.4); 1.6052 (1.4); 1.5965 (1.3); 1.5844 (1.0); 1.5724 (0.6); 1.3557 (0.4); 1.3355 (0.6); 1.2338 (0.5); 1.2245 (0.8); - 0.0006 (1.8); -0.0110 (0.9) I.1-526:1H NMR (400.0MHz, CDCl3): δ= 7.5085 (0.8); 7.4890 (1.3); 7.4420 (0.9); 7.4230 (1.7); 7.4014 (1.6); 7.3966 (2.1); 7.3565 (1.4); 7.3375 (0.9); 7.2649 (0.6); 7.2615 (37.0); 7.1115 (27.2); 5.3901 (0.6); 4.6910 (1.8); 4.6534 (2.0); 4.1345 (1.8); 4.0969 (1.6); 3.9441 (0.6); 3.9335 (0.7); 3.9234 (1.1); 3.9133 (0.8); 3.9029 (0.7); 3.5347 (0.5); 3.5189 (0.8); 3.5007 (1.3); 3.4853 (1.1); 3.4674 (0.9); 3.4495 (1.0); 3.4347 (1.1); 3.4172 (0.7); 2.8491 (2.0); 2.8314 (3.9); 2.8137 (1.8); 2.5025 (1.3); 2.4912 (1.3); 2.4665 (1.5); 2.4554 (2.0); 2.4371 (0.9); 2.4347 (0.8); 2.4141 (0.8); 2.4104 (1.0); 2.3958 (1.0); 2.3861 (1.1); 2.3719 (1.2); 2.3433 (0.5); 2.3289 (0.6); 2.3185 (16.0); 2.1993 (0.7); 2.1862 (0.5); 2.1753 (0.7); 2.1669 (0.8); 2.1622 (0.5); 2.1426 (0.7); 2.0674 (1.6); 2.0459 (1.6); 2.0313 (1.4); 2.0098 (1.4); 1.7205 (0.6); 1.7110 (0.6); 1.6979 (0.6); 1.6873 (0.5); - 0.0002 (12.3) I.1-527:1H NMR (400.0 MHz, CDCl3): δ= 7.5204 (1.4); 7.2615 (276.4); 7.2548 (0.8); 7.2539 (0.6); 7.2531 (0.6); 7.2114 (1.3); 7.2056 (7.2); 7.1997 (3.2); 7.1896 (5.0); 7.1834 (25.2); 7.1786 (4.8); 7.1650 (14.6); 7.1632 (14.4); 7.1427 (5.0); 7.1407 (4.3); 7.1244 (1.1); 7.1129 (2.0); 7.1067 (1.0); 7.0996 (3.9); 7.0910 (1.7); 7.0877 (2.2); 7.0831 (2.8); 7.0811 (2.9); 7.0732 (3.8); 7.0682 (1.4); 7.0618 (2.2); 7.0569 (4.0); 7.0540 (11.1); 7.0492 (7.2); 7.0472 (7.6); 7.0438 (7.0); 7.0398 (12.2); 7.0354 (3.8); 7.0291 (4.6); 7.0202 (0.8); 6.9974 (1.5); 5.4183 (2.3); 5.2994 (2.3); 4.8484 (4.6); 4.8447 (4.5); 4.8097 (5.2); 4.8060 (5.1); 4.2338 (6.7); 4.1951 (6.0); 3.9321 (1.1); 3.9210 (2.2); 3.9102 (2.8); 3.9002 (3.1); 3.8901 (2.8); 3.8792 (2.3); 3.8681 (1.1); 3.5481 (1.0); 3.5319 (2.7); 3.5140 (5.8); 3.5008 (6.6); 3.4993 (6.6); 3.4862 (5.6); 3.4691 (2.8); 3.4520 (0.9); 2.8266 (8.3); 2.8090 (16.0); 2.7915 (7.0); 2.5917 (4.8); 2.5809 (4.7); 2.5556 (5.5); 2.5447 (5.4); 2.5126 (0.9); 2.4942 (1.2); 2.4907 (1.2); 2.4704 (3.4); 2.4512 (3.1); 2.4477 (2.9); 2.4276 (2.9); 2.4178 (3.5); 2.4030 (4.1); 2.3937 (4.8); 2.3791 (4.8); 2.3749 (1.7); 2.3601 (1.4); 2.3507 (2.1); 2.3362 (2.0); 2.2599 (1.8); 2.2408 (2.7); 2.2361 (1.7); 2.2273 (2.2); 2.2218 (1.8); 2.2167 (2.3); 2.2084 (3.0); 2.2032 (2.0); 2.1979 (1.4); 2.1891 (1.9); 2.1838 (2.4); 2.1649 (1.3); 2.1346 (6.0); 2.1123 (5.9); 2.0984 (5.3); 2.0762 (5.2); 1.8064 (1.7); 1.7951 (1.8); 1.7922 (2.1); 1.7809 (2.3); 1.7716 (2.2); 1.7684 (1.9); 1.7623 (1.8); 1.7590 (2.2); 1.7477 (2.0); 1.7387 (1.6); 1.7356 (1.4); 1.7240 (1.3); 1.4557 (1.2); 0.0080 (2.5); -0.0002 (89.4); - 0.0085 (2.5) I.1-528:1H NMR (400.0MHz, CDCl3): δ= 7.5213 (1.0); 7.3828 (3.5); 7.3798 (4.2); 7.3779 (4.6); 7.3750 (4.3); 7.3631 (4.3); 7.3602 (4.9); 7.3582 (5.8); 7.3553 (5.1); 7.3210 (6.9); 7.3170 (11.2); 7.3129 (6.0); 7.2712 (1.0); 7.2696 (1.3); 7.2624 (175.4); 7.2566 (1.0); 7.2558 (0.8); 7.2550 (0.5); 7.2542 (0.5); 7.2001 (6.2); 7.1808 (13.4); 7.1614 (8.0); 7.1231 (1.3); 7.1149 (5.3); 7.1122 (8.6); 7.1110 (7.7); 7.1081 (6.1); 7.0981 (4.8); 7.0960 (4.2); 7.0929 (4.8); 7.0918 (5.0); 7.0891 (4.6); 7.0824 (2.9); 7.0797 (3.2); 7.0719 (4.7); 7.0659 (1.6); 7.0603 (2.0); 7.0557 (4.6); 7.0524 (9.6); 7.0455 (9.3); 7.0422 (7.1); 7.0374 (12.5); 7.0289 (5.3); 7.0267 (4.7); 7.0165 (0.9); 7.0099 (0.8); 6.9983 (1.0); 5.4452 (2.4); 4.8476 (4.9); 4.8439 (4.8); 4.8089 (5.5); 4.8051 (5.4); 4.2337 (7.1); 4.1949 (6.3); 3.9411 (1.2); 3.9300 (2.4); 3.9190 (2.9); 3.9084 (3.2); 3.8990 (2.9); 3.8880 (2.5); 3.8770 (1.2); 3.5608 (0.7); 3.5433 (1.7); 3.5267 (3.2); 3.5093 (5.5); 3.4941 (5.5); 3.4797 (5.3); 3.4770 (3.2); 3.4648 (5.3); 3.4478 (3.2); 3.4308 (1.6); 3.4137 (0.7); 2.7917 (8.3); 2.7744 (16.0); 2.7570 (7.1); 2.5937 (5.1); 2.5828 (5.0); 2.5576 (5.9); 2.5467 (5.7); 2.5197 (1.0); 2.5012 (1.4); 2.4977 (1.2); 2.4780 (3.6); 2.4582 (3.3); 2.4547 (3.0); 2.4349 (3.0); 2.4222 (3.7); 2.4075 (4.4); 2.3981 (5.2); 2.3836 (5.2); 2.3794 (1.8); 2.3647 (1.4); 2.3551 (2.3); 2.3408 (2.3); 2.2730 (1.9); 2.2539 (3.0); 2.2491 (1.8); 2.2404 (2.3); 2.2350 (1.9); 2.2298 (2.4); 2.2214 (3.2); 2.2163 (2.1); 2.2110 (1.4); 2.2023 (2.0); 2.1970 (2.5); 2.1782 (1.3); 2.1259 (6.5); 2.1034 (6.3); 2.0898 (5.6); 2.0673 (5.5); 2.0066 (1.4); 1.8159 (2.0); 1.8045 (2.3); 1.8017 (2.6); 1.7905 (3.1); 1.7810 (3.5); 1.7779 (3.3); 1.7718 (3.4); 1.7687 (3.9); 1.7667 (3.7); 1.7596 (3.3); 1.7574 (3.5); 1.7482 (2.7); 1.7451 (2.4); 1.7336 (2.0); 0.0080 (1.8); 0.0064 (0.6); 0.0056 (0.7); 0.0047 (0.8); 0.0039 (1.1); 0.0023 (2.6); -0.0002 (58.3); -0.0051 (0.7); -0.0059 (0.5); -0.0085 (1.6) I.1-529:1H NMR (400.0 MHz, CDCl3): δ= 7.5205 (0.8); 7.3114 (0.6); 7.3010 (8.5); 7.2802 (11.9); 7.2617 (146.4); 7.2117 (0.8); 7.1892 (6.7); 7.1833 (12.8); 7.1773 (10.3); 7.1710 (3.9); 7.1565 (6.0); 7.1502 (4.0); 7.1228 (0.8); 7.1107 (1.7); 7.0979 (3.1); 7.0866 (1.8); 7.0797 (2.6); 7.0737 (3.5); 7.0620 (1.9); 7.0553 (10.4); 7.0488 (6.8); 7.0447 (6.1); 7.0414 (10.1); 7.0367 (2.9); 7.0307 (3.6); 7.0221 (0.8); 6.9977 (0.9); 5.4829 (2.2); 4.8556 (4.1); 4.8522 (4.1); 4.8168 (4.6); 4.8134 (4.6); 4.2473 (6.0); 4.2086 (5.3); 3.9505 (1.0); 3.9395 (1.9); 3.9286 (2.4); 3.9172 (2.6); 3.9083 (2.4); 3.8973 (2.0); 3.8864 (1.0); 3.5808 (0.5); 3.5634 (1.2); 3.5469 (2.7); 3.5294 (4.7); 3.5209 (2.0); 3.5137 (4.5); 3.5039 (4.3); 3.4965 (2.2); 3.4884 (4.5); 3.4713 (2.6); 3.4543 (1.2); 3.4374 (0.5); 2.9322 (8.1); 2.9149 (16.0); 2.8976 (7.0); 2.6153 (4.1); 2.6047 (4.0); 2.5791 (4.7); 2.5685 (4.5); 2.5306 (0.9); 2.5115 (1.2); 2.5077 (1.1); 2.4878 (3.1); 2.4688 (2.8); 2.4645 (2.5); 2.4459 (2.6); 2.4299 (2.8); 2.4153 (3.3); 2.4058 (3.9); 2.3914 (4.0); 2.3872 (1.5); 2.3724 (1.1); 2.3628 (1.8); 2.3485 (1.8); 2.2856 (1.5); 2.2666 (2.4); 2.2618 (1.4); 2.2529 (1.8); 2.2476 (1.4); 2.2425 (1.9); 2.2340 (2.7); 2.2289 (1.6); 2.2237 (1.0); 2.2148 (1.5); 2.2097 (2.0); 2.1908 (1.0); 2.1331 (5.0); 2.1102 (4.9); 2.0970 (4.4); 2.0741 (4.2); 1.8267 (1.4); 1.8127 (1.8); 1.8022 (2.2); 1.7922 (2.1); 1.7795 (2.1); 1.7686 (2.0); 1.7590 (1.7); 1.7561 (1.6); 1.7444 (1.7); 1.7063 (1.9); 0.0079 (1.6); -0.0002 (46.6); -0.0085 (1.2) I.1-535:1H NMR (400.0MHz, CDCl3): δ= 7.2622 (28.4); 7.1141 (19.2); 6.8093 (1.4); 6.7878 (1.9); 6.6949 (0.7); 6.6899 (1.4); 6.6824 (1.7); 6.6777 (1.8); 6.6735 (1.3); 4.7194 (1.1); 4.6819 (1.2); 4.1171 (1.1); 4.0795 (1.0); 3.9428 (0.7); 3.8604 (15.8); 3.8581 (16.0); 3.4772 (0.7); 3.4620 (0.9); 3.4444 (0.9); 3.4297 (0.7); 2.7305 (1.1); 2.7130 (2.3); 2.6954 (1.0); 2.5025 (0.8); 2.4907 (0.8); 2.4858 (0.6); 2.4663 (1.3); 2.4547 (0.8); 2.4361 (0.5); 2.4219 (0.6); 2.4119 (0.7); 2.3979 (0.6); 2.3232 (9.9); 2.0777 (0.9); 2.0565 (0.9); 2.0416 (0.8); 2.0204 (0.8); - 0.0002 (5.0) I.1-536:1H NMR (400.0MHz, CDCl3): δ= 7.2635 (11.5); 7.2470 (0.6); 7.2426 (0.6); 7.2281 (0.8); 7.2267 (0.8); 7.2237 (0.9); 7.2079 (0.7); 7.2035 (0.7); 7.1060 (0.9); 7.1016 (0.9); 7.0873 (1.2); 7.0833 (1.5); 7.0711 (0.5); 7.0583 (1.0); 7.0389 (1.3); 7.0307 (2.0); 7.0286 (1.2); 7.0219 (1.5); 7.0204 (1.5); 7.0155 (0.6); 7.0113 (0.9); 6.9205 (0.8); 6.9178 (0.9); 6.9020 (1.3); 6.8993 (1.6); 6.8829 (1.7); 6.8808 (1.8); 6.8618 (1.2); 4.8305 (0.8); 4.8270 (0.8); 4.7917 (0.9); 4.7882 (0.8); 4.2146 (1.1); 4.1758 (1.0); 3.9003 (0.5); 3.8983 (0.5); 3.8297 (0.8); 3.8251 (16.0); 3.4764 (1.2); 3.4719 (0.9); 3.4629 (1.0); 3.4585 (1.2); 2.8261 (1.4); 2.8094 (2.7); 2.7927 (1.3); 2.5611 (0.8); 2.5500 (0.8); 2.5254 (0.9); 2.5143 (0.9); 2.4612 (0.6); 2.4418 (0.5); 2.4062 (0.6); 2.3916 (0.7); 2.3821 (0.8); 2.3676 (0.8); 2.1896 (0.5); 2.0897 (1.0); 2.0672 (1.0); 2.0540 (0.9); 2.0314 (0.8); - 0.0002 (3.6) I.1-537:1H NMR (400.0 MHz, CDCl3): δ= 7.2619 (50.3); 7.0993 (0.6); 7.0723 (0.6); 7.0567 (0.7); 7.0528 (1.5); 7.0459 (1.4); 7.0426 (1.1); 7.0379 (1.9); 7.0294 (0.8); 7.0274 (0.7); 6.8156 (1.4); 6.7940 (2.1); 6.7121 (0.8); 6.7070 (1.5); 6.6996 (1.8); 6.6949 (1.9); 6.6906 (1.3); 4.8496 (0.8); 4.8461 (0.7); 4.8110 (0.8); 4.8073 (0.8); 4.2323 (1.1); 4.1936 (1.0); 3.9200 (0.6); 3.8672 (16.0); 3.8622 (16.0); 3.5004 (1.2); 3.4971 (1.0); 3.4860 (1.0); 3.4825 (1.2); 2.7612 (1.2); 2.7438 (2.5); 2.7264 (1.1); 2.5867 (0.8); 2.5756 (0.8); 2.5506 (0.9); 2.5395 (0.9); 2.4867 (0.6); 2.4668 (0.6); 2.4635 (0.5); 2.4442 (0.5); 2.4332 (0.6); 2.4185 (0.7); 2.4090 (0.8); 2.3946 (0.9); 2.2253 (0.5); 2.1335 (1.0); 2.1114 (0.9); 2.0975 (0.8); 2.0753 (0.8); 0.0079 (0.5); -0.0002 (16.3) I.1-542:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.9699 (0.5); 7.0570 (0.6); 7.0536 (0.6); 4.7310 (0.7); 4.6912 (0.8); 4.2321 (0.9); 4.1924 (0.8); 3.7806 (0.5); 3.5759 (16.0); 3.3644 (17.6); 3.0358 (0.7); 3.0263 (0.8); 3.0216 (0.8); 3.0122 (0.7); 2.5108 (7.3); 2.5062 (14.7); 2.5016 (20.6); 2.4970 (14.4); 2.4924 (6.3); 2.4762 (0.8); 2.4646 (0.7); 2.3579 (0.5); 2.3383 (0.5); 2.3050 (1.4); 2.2865 (3.0); 2.2740 (0.6); 2.2676 (1.6); 2.2638 (0.8); 2.2501 (0.6); 2.1890 (0.8); 2.1676 (0.8); 2.1541 (0.7); 2.1325 (0.7); 1.6347 (1.2); 1.6164 (1.7); 1.5984 (1.0); -0.0002 (0.7) I.1-545:1H NMR (400.0MHz, CDCl3): δ= 7.2918 (1.9); 7.2863 (1.1); 7.2749 (1.0); 7.2694 (2.9); 7.2626 (24.2); 7.1681 (7.4); 7.1629 (2.5); 7.1508 (2.3); 7.1445 (1.1); 7.1172 (25.7); 5.4808 (0.6); 5.2982 (7.9); 4.6998 (1.8); 4.6622 (2.0); 4.1443 (1.8); 4.1067 (1.6); 3.9543 (0.6); 3.9436 (0.8); 3.9334 (1.0); 3.9235 (0.8); 3.9128 (0.7); 3.4984 (0.8); 3.4806 (1.4); 3.4650 (1.6); 3.4476 (1.6); 3.4325 (1.2); 3.4153 (0.8); 2.8928 (2.3); 2.8753 (4.6); 2.8579 (2.0); 2.5212 (1.2); 2.5097 (1.5); 2.4850 (2.3); 2.4737 (1.4); 2.4648 (0.9); 2.4621 (0.8); 2.4419 (0.7); 2.4293 (0.8); 2.4151 (1.0); 2.4051 (1.1); 2.3911 (1.1); 2.3623 (0.5); 2.3213 (16.0); 2.2209 (0.7); 2.1968 (0.6); 2.1884 (0.8); 2.1836 (0.5); 2.1640 (0.7); 2.0838 (1.5); 2.0620 (1.5); 2.0476 (1.3); 2.0258 (1.3); 1.7488 (0.6); 1.7390 (0.6); 1.7262 (0.6); 1.7157 (0.5); -0.0002 (8.4) I.1-557:1H NMR (400.1 MHz, d6-DMSO): δ= 19.0524 (0.8); 18.7806 (0.8); 18.5751 (0.8); 17.5432 (0.8); 14.8014 (0.8); 10.4423 (0.8); 8.3532 (0.8); 8.3495 (0.8); 8.2886 (4.0); 8.2482 (4.8); 8.2443 (4.5); 8.2005 (0.9); 8.1750 (0.8); 7.3607 (1.9); 7.3373 (3.9); 7.3315 (2.4); 7.3147 (1.9); 7.3076 (1.3); 7.2734 (1.6); 7.2555 (1.8); 7.2498 (3.1); 7.2442 (2.1); 7.2318 (1.2); 7.2262 (2.2); 7.2016 (1.3); 7.1736 (4.7); 7.1569 (9.0); 7.1515 (8.5); 7.1356 (6.5); 7.1177 (1.9); 7.1112 (2.5); 7.1057 (1.5); 7.0934 (2.4); 7.0876 (4.4); 7.0820 (2.4); 7.0729 (1.8); 7.0643 (2.0); 7.0592 (1.4); 7.0000 (1.1); 6.9953 (1.3); 6.9780 (1.7); 6.9719 (3.2); 6.9666 (1.9); 6.9482 (2.2); 6.9205 (4.9); 6.9150 (6.0); 6.8985 (10.1); 6.8820 (5.4); 6.8758 (4.0); 5.7681 (0.8); 4.2471 (1.5); 4.2393 (1.3); 3.9892 (1.9); 3.9811 (1.8); 3.6110 (0.8); 3.5256 (0.9); 3.5089 (1.4); 3.4775 (1.0); 3.4510 (0.9); 3.4449 (0.8); 3.4334 (1.0); 3.4094 (3.8); 3.3730 (3.7); 3.3611 (7.2); 3.3101 (3466.6); 3.2608 (8.4); 3.2382 (2.1); 3.2123 (2.8); 3.1903 (1.0); 3.1687 (6.2); 3.0134 (0.8); 2.9895 (0.9); 2.6963 (1.3); 2.6781 (6.0); 2.6739 (9.7); 2.6691 (12.7); 2.6644 (10.0); 2.6599 (6.4); 2.6508 (1.4); 2.6441 (1.5); 2.5994 (2.0); 2.5954 (2.2); 2.5678 (1.8); 2.5553 (3.6); 2.5505 (4.0); 2.5462 (3.4); 2.5420 (2.1); 2.5226 (18.8); 2.5178 (26.4); 2.5092 (663.4); 2.5046 (1486.8); 2.5001 (2112.1); 2.4955 (1515.8); 2.4909 (706.4); 2.4550 (5.1); 2.4504 (5.3); 2.4458 (4.2); 2.4349 (1.7); 2.4188 (1.4); 2.4161 (1.4); 2.4064 (2.0); 2.3969 (1.3); 2.3570 (0.8); 2.3363 (4.0); 2.3315 (8.6); 2.3269 (12.4); 2.3223 (8.9); 2.3178 (4.3); 2.2569 (0.9); 2.2425 (1.1); 2.2194 (2.3); 2.2059 (1.9); 2.1976 (2.2); 2.1893 (1.7); 2.1785 (2.2); 2.1644 (2.3); 2.1520 (3.7); 2.1351 (3.8); 2.1170 (2.8); 2.0971 (1.4); 2.0712 (5.2); 1.2391 (1.6); 1.2162 (13.6); 1.1991 (13.5); 1.1741 (16.0); 1.1568 (15.6); 0.1460 (1.7); 0.0116 (2.7); 0.0082 (10.6); 0.0000 (384.6) I.1-561:1H NMR (400.0 MHz, CDCl3): δ= 7.2620 (36.0); 7.1364 (0.7); 7.1176 (29.3); 7.0989 (1.5); 7.0942 (0.8); 7.0779 (0.7); 6.8360 (0.5); 6.8295 (0.6); 6.8272 (0.7); 6.8152 (0.8); 6.8071 (2.4); 6.7863 (1.5); 6.7842 (1.3); 6.7763 (0.7); 6.7604 (0.9); 6.7540 (0.6); 5.3835 (0.5); 5.2986 (1.5); 4.7020 (1.8); 4.6645 (2.0); 4.1351 (1.8); 4.0975 (1.6); 3.9384 (0.6); 3.9279 (0.8); 3.9177 (1.1); 3.9076 (0.8); 3.8972 (0.7); 3.4539 (0.8); 3.4362 (1.2); 3.4257 (0.6); 3.4207 (1.2); 3.4086 (1.1); 3.4034 (0.6); 3.3933 (1.2); 3.3761 (0.7); 2.7847 (1.4); 2.7673 (2.7); 2.7499 (1.3); 2.4974 (1.5); 2.4860 (1.3); 2.4731 (0.9); 2.4613 (1.5); 2.4499 (2.1); 2.4307 (0.7); 2.4188 (0.8); 2.4046 (1.0); 2.3946 (1.1); 2.3805 (1.1); 2.3518 (0.5); 2.3378 (0.6); 2.3245 (16.0); 2.2054 (0.8); 2.1922 (0.6); 2.1812 (0.7); 2.1728 (0.9); 2.1681 (0.6); 2.1533 (0.5); 2.1485 (0.7); 2.0804 (1.6); 2.0590 (1.6); 2.0442 (1.4); 2.0228 (1.4); 1.7479 (0.6); 1.7379 (0.6); 1.7253 (0.6); 1.7148 (0.5); -0.0002 (10.9) I.1-562:1H NMR (400.0MHz, CDCl3): δ= 7.3829 (0.8); 7.3803 (1.0); 7.3782 (1.0); 7.3756 (0.9); 7.3632 (1.0); 7.3604 (1.1); 7.3584 (1.3); 7.3558 (1.1); 7.3038 (1.5); 7.2997 (2.5); 7.2955 (1.4); 7.2612 (38.6); 7.1921 (1.4); 7.1728 (2.9); 7.1533 (1.7); 7.1151 (28.1); 7.0899 (1.6); 7.0708 (1.0); 5.3541 (0.5); 5.2984 (1.8); 4.7062 (1.5); 4.6687 (1.7); 4.1309 (1.6); 4.0934 (1.5); 3.9385 (0.6); 3.9281 (0.8); 3.9179 (0.6); 3.4928 (0.6); 3.4752 (0.9); 3.4596 (0.8); 3.4428 (0.6); 3.4263 (0.7); 3.4113 (0.8); 3.3941 (0.6); 2.7567 (1.8); 2.7393 (3.4); 2.7220 (1.6); 2.5058 (0.9); 2.4942 (0.8); 2.4871 (0.7); 2.4692 (1.3); 2.4584 (1.0); 2.4441 (0.6); 2.4349 (0.6); 2.4206 (0.6); 2.4107 (0.7); 2.3965 (0.7); 2.3235 (16.0); 2.1805 (0.5); 2.0748 (0.8); 2.0534 (0.8); 2.0387 (0.7); 2.0174 (0.6); -0.0002 (12.7) I.1-565:1H NMR (400.0MHz, CDCl3): δ= 7.2621 (36.5); 7.1409 (0.6); 7.1188 (22.5); 6.2271 (0.6); 4.7750 (1.8); 4.7375 (2.0); 4.0818 (1.8); 4.0444 (1.6); 3.9702 (0.5); 3.9612 (0.8); 3.9511 (0.9); 3.9404 (0.8); 3.3028 (0.6); 3.2857 (1.0); 3.2706 (1.0); 3.2536 (0.6); 3.2473 (1.0); 3.2329 (1.0); 3.2163 (0.6); 2.5482 (1.1); 2.5359 (1.5); 2.5127 (2.1); 2.5004 (1.3); 2.4919 (1.0); 2.4700 (0.6); 2.4308 (0.7); 2.4182 (0.9); 2.4063 (1.0); 2.3936 (1.3); 2.3888 (2.5); 2.3718 (4.4); 2.3636 (1.0); 2.3546 (2.5); 2.3259 (1.8); 2.3190 (16.0); 2.2092 (0.7); 2.1846 (0.8); 2.1805 (1.6); 2.1770 (1.0); 2.1726 (0.6); 2.1598 (1.5); 2.1523 (0.8); 2.1449 (1.2); 2.1242 (1.1); 1.8348 (0.6); 1.8269 (0.7); 1.8177 (2.4); 1.8012 (3.1); 1.7940 (1.2); 1.7840 (2.4); 1.7674 (0.6); 1.4319 (0.6); 1.2216 (1.2); -0.0002 (10.7) I.1-569:1H NMR (400.0 MHz, CDCl3): δ= 7.5189 (10.3); 7.3794 (6.3); 7.3746 (6.5); 7.3602 (7.2); 7.3554 (7.5); 7.3335 (1.2); 7.3088 (1.3); 7.2937 (2.1); 7.2898 (2.1); 7.2858 (2.5); 7.2600 (2050.6); 7.2533 (6.5); 7.2524 (5.5); 7.2516 (5.9); 7.2500 (2.9); 7.2492 (2.8); 7.2484 (2.1); 7.2477 (2.0); 7.2453 (1.5); 7.2445 (1.3); 7.2332 (1.5); 7.2317 (1.2); 7.2099 (3.8); 7.1729 (5.4); 7.1538 (14.4); 7.1347 (11.8); 7.1254 (8.6); 7.1206 (9.0); 7.1117 (2.5); 7.1063 (4.4); 7.0990 (3.6); 7.0872 (1.7); 7.0822 (2.4); 7.0746 (3.7); 7.0561 (11.8); 7.0495 (6.4); 7.0458 (6.9); 7.0430 (9.1); 7.0374 (3.0); 7.0317 (3.8); 6.9960 (10.6); 5.4251 (2.2); 4.8537 (3.7); 4.8112 (4.6); 4.2458 (5.6); 4.2078 (5.0); 3.9341 (1.8); 3.9228 (2.3); 3.9130 (2.5); 3.9032 (2.4); 3.8918 (1.9); 3.5566 (2.3); 3.5485 (2.0); 3.5387 (5.1); 3.5315 (4.9); 3.5236 (4.9); 3.5160 (5.1); 3.5059 (2.3); 3.4991 (2.5); 3.0103 (7.7); 2.9929 (16.0); 2.9755 (7.2); 2.6007 (3.8); 2.5901 (4.0); 2.5646 (4.6); 2.5537 (4.4); 2.5118 (1.2); 2.4887 (3.1); 2.4699 (2.5); 2.4454 (2.5); 2.4286 (2.9); 2.4141 (3.4); 2.4045 (4.0); 2.3901 (4.0); 2.3707 (1.2); 2.3616 (1.9); 2.3473 (2.1); 2.2673 (1.6); 2.2480 (2.3); 2.2346 (1.7); 2.2241 (1.9); 2.2153 (2.3); 2.2106 (1.7); 2.1967 (1.9); 2.1908 (2.0); 2.1720 (1.2); 2.1325 (5.0); 2.1099 (4.9); 2.0963 (4.3); 2.0737 (4.3); 1.8045 (1.8); 1.7949 (1.9); 1.7844 (2.0); 1.7692 (2.0); 1.7600 (1.9); 1.7505 (1.5); 1.5999 (9.2); 1.4632 (1.9); 0.1458 (2.2); 0.0110 (2.5); 0.0079 (19.2); 0.0062 (6.6); 0.0054 (7.6); 0.0046 (9.0); 0.0037 (12.3); - 0.0002 (674.6); -0.0028 (35.2); -0.0044 (13.0); -0.0052 (7.7); -0.0061 (5.8); -0.0069 (5.0); -0.0085 (19.7); -0.0108 (2.6); -0.0117 (2.2); -0.0124 (2.1); -0.0132 (1.4); -0.0141 (1.3); -0.0148 (1.6); -0.0172 (1.1); - 0.0196 (1.1); -0.0504 (1.7); -0.1495 (1.7) I.1-570:1H NMR (400.0MHz, CDCl3): δ= 7.5194 (0.5); 7.2606 (101.1); 7.1825 (0.8); 7.1751 (0.6); 7.1672 (0.8); 7.1599 (8.6); 7.1547 (5.8); 7.1377 (0.6); 7.1300 (0.8); 7.1163 (28.1); 6.9965 (0.5); 5.2827 (0.6); 4.7029 (1.8); 4.6654 (2.0); 4.1391 (1.8); 4.1016 (1.6); 3.9416 (0.6); 3.9316 (0.7); 3.9211 (1.1); 3.9105 (0.7); 3.9006 (0.7); 3.4977 (0.8); 3.4794 (1.3); 3.4641 (1.1); 3.4585 (0.6); 3.4462 (0.7); 3.4407 (1.1); 3.4259 (1.2); 3.4086 (0.7); 2.7889 (2.3); 2.7712 (4.6); 2.7536 (2.0); 2.4969 (1.3); 2.4855 (1.3); 2.4688 (0.9); 2.4608 (1.5); 2.4493 (2.2); 2.4264 (0.8); 2.4210 (0.9); 2.4066 (1.0); 2.3968 (1.2); 2.3825 (1.1); 2.3397 (0.5); 2.3237 (16.0); 2.1983 (0.7); 2.1851 (0.5); 2.1742 (0.7); 2.1657 (0.8); 2.1610 (0.6); 2.1415 (0.7); 2.0759 (1.6); 2.0547 (1.5); 2.0398 (1.4); 2.0186 (1.4); 1.7357 (0.5); 1.7252 (0.6); 1.7153 (0.6); 1.7025 (0.6); 1.6919 (0.5); 0.0080 (1.0); -0.0002 (34.0); -0.0085 (0.9) I.1-572:1H NMR (400.0 MHz, CDCl3): δ= 7.7562 (2.0); 7.6093 (4.5); 7.2618 (40.2); 7.1161 (25.1); 4.6782 (1.7); 4.6406 (2.0); 4.1609 (1.5); 4.1233 (1.3); 3.9619 (0.6); 3.9514 (0.7); 3.9412 (1.0); 3.9311 (0.7); 3.9206 (0.6); 3.5227 (0.8); 3.5042 (1.1); 3.4887 (1.0); 3.4705 (0.8); 3.4521 (0.9); 3.4370 (1.0); 3.4191 (0.7); 2.9325 (1.8); 2.9146 (3.7); 2.8967 (1.6); 2.5189 (1.2); 2.5075 (1.2); 2.4827 (1.6); 2.4713 (1.4); 2.4618 (0.8); 2.4402 (0.8); 2.4197 (1.2); 2.4055 (0.8); 2.3959 (0.9); 2.3816 (0.9); 2.3174 (16.0); 2.2195 (0.6); 2.1957 (0.6); 2.1871 (0.7); 2.1630 (0.6); 2.0839 (1.5); 2.0625 (1.4); 2.0477 (1.3); 2.0262 (1.3); 1.7243 (0.5); 1.7150 (0.5); 1.7012 (0.5); -0.0002 (8.8) I.1-573:1H NMR (400.0 MHz, CDCl3): δ= 7.7604 (6.9); 7.6337 (16.0); 7.5227 (0.6); 7.2637 (122.0); 7.2603 (2.2); 7.2595 (1.6); 7.2586 (1.3); 7.2578 (1.0); 7.2570 (0.8); 7.2562 (0.7); 7.2554 (0.6); 7.2546 (0.5); 7.1244 (0.9); 7.1151 (1.3); 7.1086 (1.3); 7.0998 (3.1); 7.0873 (2.4); 7.0849 (2.2); 7.0810 (2.5); 7.0748 (5.1); 7.0665 (1.6); 7.0647 (1.6); 7.0630 (1.8); 7.0560 (7.6); 7.0480 (9.9); 7.0452 (6.2); 7.0392 (8.2); 7.0322 (3.1); 7.0286 (4.3); 7.0174 (0.8); 7.0109 (0.5); 6.9996 (0.6); 5.6265 (1.9); 4.8452 (4.1); 4.8416 (4.0); 4.8065 (4.6); 4.8029 (4.5); 4.2410 (5.8); 4.2023 (5.2); 3.9567 (0.9); 3.9456 (1.9); 3.9347 (2.4); 3.9240 (2.7); 3.9146 (2.5); 3.9037 (2.0); 3.8927 (1.0); 3.6128 (0.6); 3.5949 (1.6); 3.5790 (2.7); 3.5607 (4.2); 3.5452 (3.6); 3.5313 (1.7); 3.5272 (1.9); 3.5133 (3.0); 3.4980 (3.6); 3.4808 (2.6); 3.4637 (1.3); 3.4466 (0.7); 2.9777 (4.6); 2.9583 (7.7); 2.9435 (3.5); 2.9401 (3.6); 2.6155 (4.2); 2.6046 (4.2); 2.5792 (4.8); 2.5684 (4.7); 2.5128 (0.8); 2.4935 (1.0); 2.4900 (1.0); 2.4699 (3.0); 2.4504 (2.8); 2.4469 (2.7); 2.4274 (2.8); 2.4222 (3.1); 2.4074 (3.4); 2.3981 (4.1); 2.3836 (4.1); 2.3793 (1.4); 2.3645 (1.0); 2.3551 (1.8); 2.3408 (1.7); 2.2809 (1.6); 2.2618 (2.6); 2.2573 (1.6); 2.2484 (2.0); 2.2428 (1.6); 2.2379 (2.2); 2.2294 (2.9); 2.2244 (1.8); 2.2190 (1.2); 2.2102 (1.7); 2.2051 (2.3); 2.1862 (1.2); 2.1495 (5.4); 2.1270 (5.3); 2.1132 (4.7); 2.0908 (4.6); 1.8044 (1.3); 1.7931 (1.5); 1.7903 (1.7); 1.7793 (1.9); 1.7699 (1.9); 1.7666 (1.6); 1.7604 (1.5); 1.7572 (1.9); 1.7461 (1.7); 1.7370 (1.3); 1.7339 (1.2); 1.7224 (1.1); 0.0080 (1.1); 0.0023 (1.5); -0.0002 (38.7); - 0.0050 (0.7); -0.0059 (0.6); -0.0067 (0.5); -0.0085 (1.2) I.1-594:1H NMR (400.0MHz, d6-DMSO): δ= 8.3935 (2.8); 8.3733 (3.0); 7.2803 (1.2); 7.2622 (3.4); 7.2500 (1.5); 7.2446 (4.4); 7.2262 (8.3); 7.2177 (15.8); 7.2091 (3.4); 7.1851 (2.7); 7.1581 (5.3); 7.1379 (9.8); 7.1042 (5.7); 7.0837 (7.2); 7.0634 (2.7); 4.6179 (1.8); 4.5803 (2.0); 4.4744 (0.8); 4.4607 (1.0); 4.4490 (1.0); 4.4208 (0.9); 3.9881 (1.9); 3.9499 (1.6); 3.8788 (1.7); 3.8411 (1.5); 3.6314 (9.1); 3.5654 (2.4); 3.1661 (2.4); 3.0799 (1.2); 3.0557 (1.5); 3.0465 (1.4); 2.8363 (1.8); 2.8101 (2.0); 2.8017 (1.5); 2.7767 (1.4); 2.6760 (1.4); 2.6713 (1.9); 2.6667 (1.3); 2.5983 (1.3); 2.5780 (3.8); 2.5589 (4.0); 2.5392 (1.7); 2.5248 (6.7); 2.5201 (9.1); 2.5114 (116.1); 2.5068 (251.5); 2.5022 (347.2); 2.4976 (240.9); 2.4931 (107.4); 2.4721 (1.7); 2.4611 (3.1); 2.3336 (1.4); 2.3291 (2.0); 2.3243 (1.5); 2.2986 (0.7); 2.2795 (0.8); 2.2578 (1.5); 2.2374 (1.8); 2.2140 (1.0); 2.1844 (1.3); 2.1714 (1.6); 2.1606 (1.7); 2.1472 (1.9); 2.1293 (0.9); 2.1159 (2.7); 2.1049 (1.8); 2.0935 (1.2); 2.0815 (1.8); 2.0748 (1.1); 2.0589 (1.0); 1.8439 (0.7); 1.8198 (0.6); 1.7689 (0.7); 1.7364 (0.8); 1.7125 (0.7); 1.6465 (0.7); 1.6367 (0.8); 1.3732 (1.0); 1.3552 (1.2); 1.3321 (0.6); 1.2368 (1.5); 1.1794 (6.8); 1.1761 (7.3); 1.1605 (14.4); 1.1571 (16.0); 1.1414 (6.5); 1.1381 (6.8); -0.0002 (6.9) I.2-1:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5740 (0.6); 8.5594 (1.2); 8.5448 (0.6); 7.3984 (0.5); 7.3921 (5.0); 7.3870 (1.7); 7.3759 (2.0); 7.3707 (7.3); 7.3645 (0.9); 7.2835 (0.8); 7.2774 (5.5); 7.2721 (1.6); 7.2609 (1.4); 7.2558 (3.8); 4.2738 (3.2); 4.2589 (3.1); 3.5265 (1.3); 3.5043 (2.2); 3.5025 (2.3); 3.4804 (2.0); 3.4091 (4.6); 3.3804 (2.1); 3.3655 (2.1); 3.3563 (1.4); 3.3414 (1.5); 3.1637 (0.6); 3.1600 (0.8); 3.1488 (0.6); 3.1446 (0.8); 3.1417 (0.9); 3.1378 (0.6); 3.1264 (0.8); 3.0189 (0.7); 2.9995 (0.8); 2.9857 (1.9); 2.9662 (1.9); 2.9467 (1.8); 2.9286 (1.8); 2.9134 (0.7); 2.8953 (0.7); 2.5236 (0.6); 2.5189 (0.8); 2.5103 (11.6); 2.5057 (25.6); 2.5011 (36.1); 2.4964 (24.8); 2.4919 (11.0); 2.4796 (0.6); 2.4608 (2.4); 2.4393 (3.5); 2.4217 (2.3); 2.3987 (0.6); 1.8499 (0.8); 1.8329 (1.0); 1.8158 (0.8); 0.8216 (10.5); 0.8057 (16.0); 0.7898 (10.2); -0.0002 (8.2) I.2-11:1H NMR (400.0MHz, CDCl3): δ= 8.5586 (1.3); 8.5561 (1.5); 8.5543 (1.5); 8.5519 (1.3); 8.5462 (1.3); 8.5438 (1.6); 8.5420 (1.5); 8.5396 (1.3); 7.7246 (1.3); 7.7201 (1.3); 7.7054 (2.4); 7.7010 (2.4); 7.6862 (1.6); 7.6818 (1.5); 7.5194 (1.0); 7.4757 (0.6); 7.4692 (5.2); 7.4644 (1.7); 7.4529 (1.8); 7.4479 (6.1); 7.4415 (0.6); 7.2857 (2.3); 7.2742 (0.5); 7.2726 (0.7); 7.2661 (3.9); 7.2654 (4.0); 7.2645 (4.6); 7.2606 (162.9); 7.2564 (2.2); 7.2556 (1.5); 7.2547 (1.0); 7.2540 (0.8); 7.2531 (0.7); 7.2523 (0.7); 7.2515 (0.7); 7.2499 (1.0); 7.2485 (1.3); 7.2475 (1.3); 7.2460 (1.3); 7.2443 (1.1); 7.2421 (1.3); 7.2405 (1.1); 7.2396 (1.1); 7.2299 (1.1); 7.2270 (1.1); 7.2105 (1.4); 7.1814 (4.0); 7.1799 (4.4); 7.1595 (3.9); 7.1579 (3.4); 7.1064 (0.8); 6.9965 (0.9); 4.6177 (5.4); 4.6060 (5.3); 4.1966 (2.2); 4.1773 (2.4); 4.1724 (2.7); 4.1531 (2.9); 3.9960 (2.7); 3.9744 (3.2); 3.9718 (2.6); 3.9501 (2.2); 3.3318 (1.2); 3.3099 (1.4); 3.2895 (1.2); 3.2672 (0.5); 3.0280 (2.1); 3.0056 (1.7); 2.9857 (3.2); 2.9633 (3.0); 2.8681 (3.3); 2.8445 (3.0); 2.8257 (2.0); 2.8021 (1.9); 2.3262 (16.0); 1.6273 (3.2); 0.0080 (1.8); -0.0002 (70.3); -0.0085 (2.0) I.2-12:1H NMR (400.0MHz, d6-DMSO): δ= 8.4468 (0.5); 7.1785 (1.9); 7.1732 (0.6); 7.1620 (0.7); 7.1566 (2.3); 6.8903 (2.8); 6.8850 (0.8); 6.8738 (0.7); 6.8685 (2.4); 4.2122 (1.4); 4.1976 (1.3); 3.7255 (16.0); 3.5129 (0.6); 3.4906 (0.9); 3.4890 (1.0); 3.4669 (0.8); 3.3730 (0.8); 3.3579 (0.8); 3.3490 (0.6); 3.3339 (0.6); 2.9843 (0.8); 2.9649 (0.8); 2.9462 (0.8); 2.9281 (0.8); 2.5100 (3.8); 2.5054 (8.3); 2.5008 (11.6); 2.4962 (8.1); 2.4916 (3.6); 2.4447 (1.1); 2.4327 (1.1); 2.4222 (1.0); 2.4137 (1.1); 0.8219 (4.6); 0.8107 (4.8); 0.8053 (4.7); 0.7941 (4.5); -0.0002 (1.3) I.2-14:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5422 (0.9); 8.5280 (1.7); 8.5136 (0.9); 7.3424 (2.1); 7.3385 (1.1); 7.3298 (1.4); 7.3236 (4.5); 7.3215 (3.9); 7.3152 (1.0); 7.3058 (5.5); 7.2543 (7.0); 7.2464 (2.5); 7.2397 (4.5); 7.2348 (3.9); 7.2264 (1.1); 7.2228 (1.0); 4.2935 (3.8); 4.2902 (3.8); 4.2788 (3.8); 4.2756 (3.7); 3.8969 (0.9); 3.5315 (1.8); 3.5077 (3.4); 3.4855 (2.7); 3.3921 (2.4); 3.3771 (2.8); 3.3680 (1.8); 3.3530 (2.0); 3.1902 (0.5); 3.1750 (0.7); 3.1709 (1.0); 3.1683 (1.2); 3.1559 (1.0); 3.1528 (1.3); 3.1492 (1.5); 3.1340 (1.2); 3.1270 (0.7); 3.0232 (1.1); 3.0038 (1.1); 2.9900 (2.7); 2.9705 (2.8); 2.9502 (2.6); 2.9322 (2.7); 2.9170 (1.1); 2.8989 (1.1); 2.5231 (0.5); 2.5096 (11.2); 2.5052 (23.7); 2.5006 (31.7); 2.4961 (22.6); 2.4916 (10.5); 2.4626 (3.6); 2.4496 (4.0); 2.4402 (3.7); 2.4306 (3.6); 2.4081 (0.6); 1.8737 (0.6); 1.8561 (1.2); 1.8389 (1.6); 1.8218 (1.2); 1.8042 (0.7); 0.8246 (14.1); 0.8122 (16.0); 0.8080 (15.4); 0.7956 (13.8); -0.0002 (4.2) I.2-16:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5398 (0.9); 7.4562 (0.9); 7.4532 (1.7); 7.4496 (0.8); 7.4381 (1.3); 7.4358 (2.2); 7.4322 (1.3); 7.3400 (0.9); 7.3361 (2.3); 7.3339 (1.4); 7.3266 (5.8); 7.3232 (4.7); 7.3187 (2.6); 7.3081 (0.9); 7.3056 (0.5); 7.3007 (1.2); 7.2898 (1.0); 4.3623 (2.1); 4.3566 (2.0); 4.3479 (2.1); 4.3423 (2.1); 3.5477 (1.0); 3.5256 (1.7); 3.5238 (1.8); 3.5017 (1.6); 3.4045 (1.4); 3.3896 (1.7); 3.3803 (1.4); 3.3657 (7.2); 3.2169 (0.5); 3.2131 (0.6); 3.1979 (0.6); 3.1949 (0.8); 3.1797 (0.6); 3.0248 (0.6); 3.0054 (0.6); 2.9915 (1.5); 2.9721 (1.5); 2.9518 (1.4); 2.9338 (1.4); 2.9186 (0.6); 2.9005 (0.6); 2.5190 (0.8); 2.5101 (7.9); 2.5055 (17.6); 2.5009 (24.7); 2.4963 (17.4); 2.4917 (7.6); 2.4782 (1.9); 2.4588 (2.3); 2.4557 (2.2); 2.4406 (1.9); 1.8576 (0.6); 1.8406 (0.8); 1.8235 (0.6); 0.8252 (8.4); 0.8088 (16.0); 0.7924 (8.2); -0.0002 (6.1) I.2-17:1H NMR (400.0MHz, d6-DMSO): δ= 8.5855 (0.8); 8.5712 (1.5); 8.5569 (0.8); 7.6134 (4.8); 7.6081 (4.9); 7.4380 (2.2); 7.4327 (2.0); 7.4172 (3.5); 7.4119 (3.4); 7.3515 (4.3); 7.3306 (2.6); 4.3318 (2.7); 4.3272 (2.7); 4.3175 (2.7); 4.3129 (2.7); 3.9308 (0.6); 3.5405 (1.5); 3.5183 (2.4); 3.5165 (2.6); 3.4944 (2.2); 3.3917 (2.0); 3.3769 (2.2); 3.3675 (1.4); 3.3528 (1.7); 3.2104 (0.5); 3.2070 (0.7); 3.2029 (0.8); 3.1923 (0.7); 3.1874 (0.9); 3.1851 (1.1); 3.1806 (0.6); 3.1698 (0.8); 3.1656 (0.5); 3.1623 (0.5); 3.0208 (0.8); 3.0014 (0.9); 2.9876 (2.1); 2.9681 (2.2); 2.9479 (2.0); 2.9298 (2.1); 2.9147 (0.8); 2.8965 (0.8); 2.5198 (0.6); 2.5112 (8.4); 2.5066 (18.5); 2.5020 (25.9); 2.4974 (18.0); 2.4928 (8.4); 2.4748 (2.5); 2.4505 (3.9); 2.4313 (2.5); 2.4080 (0.7); 2.3898 (0.6); 1.8512 (0.9); 1.8341 (1.2); 1.8170 (0.9); 0.8223 (11.9); 0.8041 (16.0); 0.7871 (11.6); -0.0002 (6.3) I.2-21:1H NMR (400.0MHz, d6-DMSO): δ= 8.6901 (1.2); 8.6752 (2.2); 7.6547 (6.9); 7.6518 (7.8); 7.6467 (2.6); 7.6351 (4.3); 7.6326 (8.6); 7.6300 (6.8); 7.6243 (0.6); 7.5139 (1.5); 7.5101 (4.4); 7.5071 (3.8); 7.4908 (4.3); 7.4879 (6.5); 7.4841 (1.6); 7.4577 (0.6); 7.4439 (0.9); 7.4364 (1.0); 7.4230 (1.4); 7.4028 (16.0); 7.3932 (6.2); 7.3879 (2.0); 7.3835 (4.3); 7.3748 (7.7); 7.3718 (5.4); 7.3577 (2.2); 7.3530 (6.1); 7.1582 (1.7); 7.1554 (3.3); 7.1527 (1.8); 7.1371 (4.8); 7.1213 (1.3); 7.1185 (2.1); 7.1157 (1.0); 5.7549 (1.1); 4.3761 (7.1); 4.3618 (6.9); 4.0686 (2.6); 4.0471 (3.7); 4.0442 (4.3); 4.0228 (3.6); 3.9297 (3.5); 3.9149 (3.6); 3.9054 (2.6); 3.8906 (2.7); 3.8090 (1.3); 3.3719 (3.4); 3.3211 (379.4); 3.2709 (4.2); 3.2207 (0.8); 2.8176 (2.5); 2.7942 (2.4); 2.7753 (4.7); 2.7520 (4.1); 2.6957 (4.4); 2.6782 (5.0); 2.6748 (2.8); 2.6700 (3.4); 2.6655 (2.2); 2.6536 (2.3); 2.6359 (2.2); 2.5509 (1.9); 2.5463 (1.5); 2.5235 (9.6); 2.5189 (13.6); 2.5102 (177.2); 2.5056 (387.1); 2.5010 (542.7); 2.4963 (376.1); 2.4917 (164.1); 2.4601 (2.5); 2.4555 (4.2); 2.4509 (5.4); 2.4462 (4.0); 2.4417 (2.3); 2.3324 (2.6); 2.3277 (3.4); 2.3230 (2.6); 2.0731 (1.6); 1.4820 (1.2); 0.9264 (1.2); -0.0002 (11.5) I.2-22:1H NMR (400.0 MHz, CDCl3): δ= 7.5203 (6.5); 7.4249 (5.5); 7.4043 (6.1); 7.3636 (4.9); 7.3575 (4.4); 7.3204 (2.0); 7.3107 (6.9); 7.3080 (7.3); 7.2949 (4.9); 7.2878 (4.5); 7.2615 (903.3); 7.2589 (209.3); 7.2517 (6.1); 7.2476 (3.2); 7.2468 (3.2); 7.2397 (2.0); 7.2365 (1.9); 7.2341 (1.3); 7.2112 (10.3); 7.1985 (1.0); 7.1621 (2.2); 7.1291 (2.2); 7.1238 (2.3); 7.1085 (1.8); 7.1034 (1.9); 6.9974 (5.0); 5.8413 (1.0); 4.4815 (0.8); 4.4663 (0.8); 4.4435 (2.4); 4.4284 (2.4); 4.4117 (2.4); 4.3971 (2.2); 4.3749 (0.8); 4.3597 (0.7); 3.7088 (1.8); 3.6916 (1.9); 3.6842 (2.2); 3.6673 (2.3); 3.5374 (2.2); 3.5157 (2.7); 3.5129 (2.6); 3.4914 (2.0); 3.1684 (0.9); 3.1494 (1.2); 3.1352 (2.1); 3.1152 (2.2); 3.0862 (2.6); 3.0676 (2.4); 3.0344 (1.3); 3.0201 (0.6); 2.7594 (0.9); 2.7388 (0.8); 2.7168 (2.5); 2.6967 (2.3); 2.6775 (2.4); 2.6534 (2.2); 2.6355 (0.8); 2.6119 (0.7); 2.0090 (0.9); 1.9492 (1.1); 1.9310 (1.7); 1.9131 (2.0); 1.8960 (1.7); 1.8790 (1.4); 1.6751 (1.4); 1.6184 (1.6); 1.6069 (4.4); 1.5604 (274.2); 1.5101 (4.0); 0.9150 (13.8); 0.9117 (16.0); 0.8983 (13.5); 0.8950 (15.2); 0.1464 (1.3); 0.0753 (0.6); 0.0466 (2.1); 0.0079 (10.7); -0.0002 (249.5); -0.0029 (57.5); -0.0085 (8.1); -0.0505 (2.6); -0.1496 (0.8) I.2-26:1H NMR (400.0 MHz, d6-DMSO): δ= 8.5315 (4.1); 8.5239 (4.3); 8.5115 (4.4); 8.5032 (4.1); 8.2049 (11.4); 7.8558 (5.2); 7.8354 (6.2); 7.6521 (3.2); 7.6486 (3.2); 7.6319 (6.2); 7.6281 (6.3); 7.6124 (3.4); 7.5058 (7.9); 7.4865 (6.0); 7.4215 (0.7); 7.2692 (4.4); 7.2503 (13.0); 7.2341 (9.9); 7.2248 (15.6); 7.2223 (16.0); 7.2174 (14.2); 7.2119 (11.2); 7.2048 (6.2); 7.1998 (6.7); 7.1952 (6.0); 7.1818 (3.7); 7.1645 (1.2); 5.3366 (2.6); 5.3173 (7.5); 5.2976 (7.6); 5.2777 (2.5); 4.4095 (0.6); 4.1318 (3.0); 4.1077 (5.9); 4.1022 (3.4); 4.0861 (5.0); 4.0805 (5.1); 4.0779 (5.8); 4.0564 (4.6); 4.0299 (4.8); 4.0149 (5.1); 4.0055 (4.0); 4.0018 (5.4); 3.9905 (4.2); 3.9869 (5.5); 3.9774 (3.2); 3.9625 (3.2); 3.3290 (47.4); 3.2960 (13.3); 3.2788 (7.9); 3.2568 (3.7); 2.9805 (2.0); 2.9725 (2.3); 2.9584 (2.4); 2.9501 (2.5); 2.9411 (3.9); 2.9326 (4.2); 2.9189 (4.2); 2.9105 (3.9); 2.8628 (2.8); 2.8556 (3.2); 2.8349 (6.8); 2.8202 (8.2); 2.8147 (5.9); 2.8075 (3.0); 2.7972 (9.8); 2.7870 (12.5); 2.7681 (8.1); 2.7650 (7.7); 2.7553 (7.5); 2.7438 (3.0); 2.7372 (6.8); 2.7257 (2.3); 2.7128 (2.3); 2.6947 (2.1); 2.6740 (2.8); 2.6695 (3.8); 2.6649 (2.7); 2.6602 (1.3); 2.5943 (0.6); 2.5499 (2.0); 2.5316 (2.7); 2.5229 (11.4); 2.5182 (16.0); 2.5095 (203.3); 2.5050 (439.3); 2.5004 (611.4); 2.4958 (431.3); 2.4912 (195.0); 2.4757 (1.8); 2.4710 (1.1); 2.4563 (1.0); 2.4479 (1.6); 2.4366 (2.7); 2.4292 (3.5); 2.4212 (2.8); 2.4171 (3.5); 2.4092 (3.3); 2.4053 (3.1); 2.3981 (3.9); 2.3897 (2.5); 2.3783 (1.9); 2.3700 (1.2); 2.3365 (1.2); 2.3317 (2.6); 2.3272 (3.6); 2.3225 (2.5); 2.0721 (1.1); 1.8555 (1.3); 1.8493 (1.3); 1.8340 (3.0); 1.8275 (3.2); 1.8142 (3.2); 1.8075 (3.4); 1.7960 (3.1); 1.7828 (3.0); 1.7760 (2.9); 1.7611 (1.2); 1.7540 (1.4); 1.2457 (0.7); 0.9327 (0.9); 0.9145 (1.9); 0.8958 (1.0); 0.8583 (1.1); 0.0080 (4.0); -0.0002 (137.7); -0.0086 (4.0) I.2-31:1H NMR (400.0 MHz, CDCl3): δ= 8.3132 (7.0); 8.3004 (7.1); 8.1306 (16.0); 7.6652 (6.9); 7.5197 (0.8); 7.2713 (0.9); 7.2697 (1.1); 7.2690 (1.2); 7.2607 (149.2); 7.1730 (0.8); 7.1487 (4.3); 7.1454 (4.5); 7.1359 (4.2); 7.1326 (4.3); 6.9967 (0.8); 6.9093 (8.2); 6.9078 (8.1); 6.8382 (0.8); 6.1246 (1.9); 5.2987 (4.2); 4.5985 (0.5); 4.5833 (0.6); 4.5589 (5.9); 4.5515 (6.0); 4.5437 (5.9); 4.5362 (5.9); 4.5119 (0.6); 4.4965 (0.6); 4.2887 (4.1); 4.2710 (4.4); 4.2649 (5.2); 4.2472 (5.2); 4.0882 (4.8); 4.0668 (6.0); 4.0645 (5.1); 4.0430 (4.0); 3.3264 (0.9); 3.3053 (2.2); 3.2877 (2.3); 3.2847 (2.8); 3.2816 (2.7); 3.2640 (2.5); 3.2608 (1.6); 3.2429 (1.1); 3.0354 (2.8); 3.0146 (2.3); 2.9925 (7.5); 2.9837 (0.9); 2.9717 (6.9); 2.9629 (0.9); 2.9537 (7.6); 2.9299 (6.7); 2.9108 (2.7); 2.8870 (2.3); 1.5612 (5.6); 1.3227 (1.1); 1.2746 (1.5); 1.2561 (0.8); 0.0080 (1.6); -0.0002 (55.6); - 0.0085 (1.6) I.2-34:1H NMR (400.0MHz, d6-DMSO): δ= 8.4829 (2.2); 7.7137 (3.4); 7.7074 (4.6); 7.7011 (4.6); 7.6952 (5.8); 7.6902 (5.7); 7.6843 (5.4); 7.6778 (5.2); 7.6719 (4.6); 7.2432 (6.3); 7.2378 (7.7); 7.2314 (5.1); 7.2157 (16.0); 7.1986 (7.4); 7.1938 (6.4); 5.3158 (3.9); 5.2949 (3.4); 4.0287 (2.6); 4.0067 (2.4); 3.9981 (3.0); 3.9763 (2.8); 3.9553 (2.2); 3.9401 (2.4); 3.9304 (3.5); 3.9158 (3.8); 3.3156 (95.1); 3.2682 (3.3); 3.2491 (2.6); 2.9287 (2.2); 2.9160 (2.2); 2.9064 (2.0); 2.8330 (3.4); 2.8113 (2.4); 2.7927 (2.4); 2.7638 (4.1); 2.7406 (5.1); 2.7289 (3.4); 2.7205 (3.9); 2.7130 (3.4); 2.7067 (3.3); 2.6940 (3.4); 2.6697 (3.1); 2.5227 (9.0); 2.5093 (174.6); 2.5048 (377.9); 2.5002 (523.1); 2.4956 (367.1); 2.4910 (163.6); 2.4258 (2.3); 2.3271 (2.8); 1.8242 (2.2); 1.7921 (2.1); 0.0079 (3.2); -0.0002 (99.6); -0.0087 (2.6) I.2-35:1H NMR (400.0MHz, CDCl3): δ= 7.4142 (0.7); 7.3996 (0.7); 7.3932 (0.5); 7.3784 (0.5); 7.2749 (1.8); 7.2719 (2.3); 7.2593 (88.1); 7.2423 (1.8); 7.2317 (0.9); 7.2200 (0.6); 6.9406 (0.5); 6.9353 (0.6); 6.9290 (0.8); 6.9232 (0.9); 6.9212 (1.0); 6.9141 (0.6); 6.9084 (1.3); 6.9020 (0.9); 6.8874 (0.6); 5.5358 (0.7); 5.5165 (0.7); 4.1157 (0.6); 4.0976 (0.6); 4.0918 (0.8); 4.0740 (0.8); 3.9712 (0.9); 3.9495 (1.1); 3.9260 (0.7); 3.2268 (0.6); 2.9800 (0.9); 2.9593 (0.7); 2.9375 (1.3); 2.9292 (0.8); 2.9169 (1.1); 2.9093 (0.6); 2.7970 (1.2); 2.7735 (1.1); 2.7545 (0.8); 2.7310 (0.7); 1.5383 (16.0); 0.0080 (1.0); -0.0002 (32.1); -0.0085 (1.0) I.2-36:1H NMR (400.0MHz, d6-DMSO): δ= 8.6951 (0.6); 8.3351 (1.2); 8.3303 (1.2); 7.7654 (0.8); 7.7591 (0.8); 7.7449 (1.0); 7.7386 (0.9); 7.5429 (2.9); 7.5371 (0.8); 7.5256 (0.9); 7.5198 (3.2); 7.5002 (1.6); 7.4797 (1.3); 7.4781 (1.3); 6.9434 (3.2); 6.9376 (0.8); 6.9262 (0.8); 6.9204 (2.8); 5.7553 (0.6); 4.3371 (1.9); 4.3225 (1.9); 3.9873 (0.6); 3.9633 (1.0); 3.9415 (0.8); 3.8657 (0.9); 3.8501 (0.9); 3.8414 (0.6); 3.8257 (0.7); 3.7390 (16.0); 3.7197 (0.6); 3.3184 (142.9); 3.2776 (0.6); 3.2684 (1.1); 2.7434 (0.5); 2.7012 (1.1); 2.6780 (1.2); 2.6747 (0.8); 2.6700 (0.8); 2.6652 (0.6); 2.6563 (1.2); 2.6378 (1.1); 2.5234 (2.1); 2.5187 (3.1); 2.5100 (44.5); 2.5055 (97.6); 2.5008 (137.3); 2.4962 (96.0); 2.4916 (42.5); 2.4603 (0.7); 2.4557 (1.1); 2.4510 (1.3); 2.4464 (0.9); 2.4420 (0.6); 2.3323 (0.6); 2.3277 (0.9); 2.3230 (0.6); 2.0733 (0.6); 0.0080 (0.6); -0.0002 (19.7); -0.0085 (0.6) I.2-37:1H NMR (400.0 MHz, CDCl3): δ= 7.3917 (1.9); 7.3831 (1.5); 7.3771 (1.9); 7.3685 (2.6); 7.3008 (0.6); 7.2965 (0.8); 7.2820 (0.9); 7.2801 (0.9); 7.2777 (1.2); 7.2759 (1.1); 7.2705 (0.6); 7.2604 (23.7); 7.2572 (2.9); 7.2514 (2.3); 7.2456 (2.0); 7.2417 (1.8); 7.2368 (3.5); 7.0017 (0.8); 6.9986 (1.0); 6.9827 (1.3); 6.9796 (1.4); 6.9636 (0.7); 6.9604 (0.8); 6.9501 (1.4); 6.9473 (1.2); 6.9294 (1.2); 6.9266 (1.0); 4.5805 (3.4); 4.5658 (3.3); 4.0044 (0.9); 3.9882 (1.0); 3.9798 (1.3); 3.9636 (1.4); 3.8920 (1.4); 3.8712 (1.5); 3.8673 (1.0); 3.8465 (1.0); 3.7551 (16.0); 3.2475 (0.7); 2.9062 (0.8); 2.8875 (0.7); 2.8638 (1.6); 2.8451 (1.4); 2.7970 (1.4); 2.7734 (1.3); 2.7546 (0.7); 2.7310 (0.6); -0.0002 (7.2) I.2-38:1H NMR (400.0MHz, d6-DMSO): δ= 8.5225 (3.6); 8.5149 (3.5); 8.5021 (3.6); 7.6485 (10.4); 7.6431 (10.3); 7.6376 (4.0); 7.5019 (2.7); 7.4965 (3.6); 7.4836 (4.6); 7.4811 (4.7); 7.4785 (5.3); 7.4758 (7.1); 7.4494 (5.9); 7.4439 (5.8); 7.4286 (12.0); 7.4244 (9.6); 7.4088 (3.7); 7.4031 (3.4); 7.2675 (3.7); 7.2428 (16.0); 7.2403 (15.4); 7.2207 (15.7); 7.2154 (11.6); 7.2103 (10.3); 7.2042 (8.4); 7.1820 (2.9); 7.1636 (1.2); 7.0576 (5.8); 7.0551 (5.3); 6.9692 (5.1); 6.9493 (4.9); 5.3329 (1.9); 5.3136 (5.7); 5.2933 (5.7); 5.2736 (1.9); 4.0763 (2.4); 4.0520 (4.6); 4.0466 (2.8); 4.0302 (4.0); 4.0227 (4.5); 4.0011 (3.4); 3.9717 (3.7); 3.9567 (4.0); 3.9448 (4.2); 3.9299 (4.3); 3.9201 (2.4); 3.9053 (2.4); 3.3645 (3.4); 3.3135 (510.2); 3.2739 (6.9); 3.2577 (4.1); 3.2361 (1.6); 2.9796 (1.7); 2.9712 (2.0); 2.9571 (2.0); 2.9489 (2.2); 2.9396 (3.3); 2.9311 (3.5); 2.9172 (3.4); 2.9092 (3.3); 2.8542 (2.6); 2.8335 (5.4); 2.8130 (4.4); 2.8062 (2.5); 2.7972 (7.1); 2.7832 (2.4); 2.7743 (6.4); 2.7633 (10.5); 2.7447 (5.9); 2.7410 (6.0); 2.7328 (5.8); 2.7205 (2.4); 2.7145 (5.5); 2.7022 (1.9); 2.6900 (2.0); 2.6738 (5.6); 2.6694 (7.3); 2.6647 (5.1); 2.5553 (3.2); 2.5506 (3.6); 2.5460 (2.8); 2.5341 (5.0); 2.5228 (21.3); 2.5180 (31.5); 2.5093 (390.1); 2.5048 (831.9); 2.5002 (1151.0); 2.4956 (811.4); 2.4911 (366.7); 2.4688 (1.5); 2.4638 (1.2); 2.4510 (2.8); 2.4459 (2.6); 2.4345 (1.8); 2.4266 (2.3); 2.4145 (2.4); 2.4026 (3.1); 2.3960 (3.3); 2.3879 (2.3); 2.3316 (4.9); 2.3270 (6.8); 2.3224 (4.9); 2.0717 (1.5); 1.8445 (1.0); 1.8287 (2.6); 1.8231 (2.6); 1.8089 (2.4); 1.8032 (2.9); 1.7976 (2.6); 1.7915 (2.3); 1.7775 (2.5); 1.7717 (2.4); 1.7559 (1.1); 1.7501 (1.1); 0.9216 (0.7); 0.8583 (0.6); 0.0080 (1.5); -0.0002 (52.2); -0.0086 (1.3) I.2-39:1H NMR (400.0 MHz, CDCl3): δ= 7.4202 (0.5); 7.4118 (0.9); 7.3972 (0.9); 7.3909 (0.7); 7.3761 (0.6); 7.2933 (0.7); 7.2770 (2.9); 7.2731 (2.2); 7.2682 (5.2); 7.2594 (85.0); 7.2476 (0.8); 6.9401 (0.6); 6.9373 (0.7); 6.9312 (0.7); 6.9251 (1.2); 6.9200 (1.1); 6.9180 (1.2); 6.9101 (0.7); 6.9043 (1.5); 6.9000 (0.9); 6.8985 (0.9); 6.8832 (0.7); 5.5354 (0.9); 5.5163 (0.8); 4.1043 (0.7); 4.0864 (0.8); 4.0804 (1.0); 4.0626 (1.0); 3.9497 (1.1); 3.9278 (1.4); 3.9045 (0.9); 3.2430 (0.6); 3.2250 (0.6); 3.2223 (0.8); 3.2196 (0.7); 3.2016 (0.6); 3.0060 (0.6); 2.9956 (1.7); 2.9840 (0.6); 2.9749 (1.3); 2.9532 (1.7); 2.9420 (0.5); 2.9326 (1.6); 2.9223 (1.0); 2.9022 (0.7); 2.8213 (1.6); 2.7976 (1.5); 2.7788 (1.1); 2.7552 (0.9); 2.6534 (0.5); 2.6427 (0.6); 2.6209 (0.6); 2.6103 (0.5); 1.8480 (0.5); 1.5409 (16.0); 0.0080 (1.0); -0.0002 (32.4); -0.0085 (0.9) I.2-40:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5157 (3.5); 8.5035 (3.4); 8.4954 (3.2); 7.9893 (8.8); 7.7752 (4.5); 7.7575 (5.2); 7.5542 (2.9); 7.5337 (5.6); 7.5112 (2.9); 7.3773 (1.5); 7.3516 (6.0); 7.3310 (4.9); 7.2693 (3.8); 7.2508 (8.6); 7.2343 (7.1); 7.2236 (16.0); 7.2115 (11.6); 7.2027 (8.3); 7.1993 (8.2); 7.1807 (7.1); 7.0456 (7.8); 7.0418 (7.5); 6.9061 (3.6); 6.9022 (3.6); 5.3368 (2.1); 5.3173 (5.9); 5.2975 (5.8); 5.2779 (1.8); 4.3426 (0.8); 4.3241 (1.4); 4.1056 (2.3); 4.0815 (4.8); 4.0757 (2.7); 4.0599 (4.1); 4.0518 (4.5); 4.0303 (3.7); 3.9989 (4.0); 3.9842 (4.0); 3.9724 (4.6); 3.9574 (4.4); 3.9481 (2.4); 3.9330 (2.5); 3.3159 (380.2); 3.2513 (3.2); 2.9802 (1.7); 2.9715 (1.8); 2.9589 (1.8); 2.9487 (2.0); 2.9399 (3.5); 2.9313 (3.7); 2.9184 (4.0); 2.9097 (3.7); 2.8907 (1.2); 2.8693 (1.2); 2.8547 (2.4); 2.8466 (2.2); 2.8336 (5.1); 2.8235 (1.9); 2.8132 (5.7); 2.8040 (5.9); 2.7945 (3.5); 2.7811 (5.8); 2.7733 (8.5); 2.7555 (5.6); 2.7481 (6.1); 2.7437 (6.8); 2.7309 (2.2); 2.7253 (5.6); 2.7128 (1.6); 2.7012 (1.8); 2.6783 (2.9); 2.6739 (6.0); 2.6693 (8.7); 2.6647 (6.1); 2.5539 (6.0); 2.5494 (11.1); 2.5449 (10.2); 2.5402 (7.2); 2.5227 (26.3); 2.5180 (36.9); 2.5093 (483.2); 2.5048 (1053.6); 2.5002 (1473.3); 2.4956 (1048.9); 2.4910 (480.8); 2.4571 (1.3); 2.4361 (2.3); 2.4279 (3.1); 2.4167 (3.1); 2.4048 (3.0); 2.3975 (3.4); 2.3899 (2.6); 2.3697 (1.9); 2.3316 (7.0); 2.3270 (9.1); 2.3224 (6.7); 2.3178 (3.1); 2.0719 (1.8); 1.8501 (1.3); 1.8297 (3.5); 1.8197 (1.4); 1.8080 (3.5); 1.7985 (3.4); 1.7764 (3.1); 1.7546 (1.3); 1.7053 (0.8); 1.6836 (1.0); 1.2478 (3.4); 0.9110 (1.6); 0.8907 (0.9); 0.8747 (1.7); 0.8584 (6.1); 0.8407 (2.4); 0.0080 (1.9); -0.0002 (64.3); -0.0086 (2.0) I.2-41:1H NMR (400.0MHz, CDCl3): δ= 8.7289 (7.2); 7.9794 (7.8); 7.9747 (7.8); 7.5284 (4.8); 7.5230 (9.4); 7.5186 (5.9); 7.4529 (3.3); 7.4505 (3.8); 7.4477 (3.0); 7.4452 (3.0); 7.4321 (5.5); 7.4298 (5.6); 7.4270 (5.5); 7.4246 (4.8); 7.3768 (7.7); 7.3563 (12.2); 7.3357 (5.2); 7.3108 (0.6); 7.2601 (369.0); 7.2104 (0.7); 7.1773 (2.6); 6.9962 (2.1); 6.9415 (3.6); 6.9376 (3.6); 6.9214 (3.3); 6.9174 (3.2); 6.7141 (7.8); 6.5296 (16.0); 6.3450 (8.1); 4.7741 (10.1); 4.7632 (10.0); 4.2299 (5.5); 4.2113 (5.6); 4.2057 (6.7); 4.1872 (7.0); 4.0528 (6.3); 4.0313 (7.7); 4.0288 (6.0); 4.0072 (5.2); 3.4180 (1.2); 3.3965 (3.0); 3.3756 (3.5); 3.3546 (3.1); 3.3331 (1.3); 3.0692 (5.1); 3.0477 (4.3); 3.0266 (8.4); 3.0050 (7.9); 2.9357 (8.5); 2.9121 (7.8); 2.8930 (4.7); 2.8693 (4.2); 2.1350 (0.5); 1.6131 (3.4); 1.3655 (0.8); 0.0694 (0.7); 0.0080 (4.0); -0.0002 (133.3); -0.0086 (3.8); -0.1494 (0.5) I.2-42:1H NMR (400.0 MHz, CDCl3): δ= 8.7265 (9.9); 7.9820 (10.5); 7.9774 (10.9); 7.9060 (4.9); 7.8852 (5.8); 7.8496 (10.0); 7.5186 (8.5); 7.5004 (8.5); 7.4801 (5.6); 7.4299 (7.6); 7.4105 (4.6); 7.3094 (2.3); 7.2945 (0.6); 7.2906 (1.3); 7.2875 (1.8); 7.2597 (961.1); 7.2267 (1.0); 7.2201 (0.9); 7.1987 (2.2); 7.1836 (3.8); 7.1600 (1.3); 6.9957 (5.5); 4.7781 (14.4); 4.7672 (14.2); 4.2752 (7.5); 4.2570 (8.1); 4.2512 (10.0); 4.2330 (9.9); 4.0919 (9.3); 4.0705 (11.2); 4.0680 (8.9); 4.0465 (7.6); 3.4381 (1.6); 3.4167 (4.3); 3.3959 (5.0); 3.3934 (4.8); 3.3751 (4.4); 3.3537 (1.9); 3.0851 (7.0); 3.0638 (5.8); 3.0423 (12.3); 3.0210 (11.4); 2.9567 (12.4); 2.9331 (11.5); 2.9140 (6.5); 2.8903 (6.0); 2.1352 (0.6); 2.0049 (1.1); 1.5577 (16.0); 1.4330 (1.5); 1.4147 (2.6); 1.3966 (1.3); 0.1460 (1.2); 0.0691 (0.8); 0.0496 (0.7); 0.0079 (10.5); -0.0002 (354.1); -0.0085 (10.4); -0.1496 (1.3) I.2-43:1H NMR (400.0 MHz, CDCl3): δ= 7.6507 (2.5); 7.6306 (5.3); 7.6099 (3.1); 7.4101 (3.5); 7.3911 (6.8); 7.3719 (3.5); 7.2595 (15.1); 7.1975 (5.1); 7.1788 (6.8); 7.1605 (5.3); 7.1292 (1.9); 7.0741 (1.2); 7.0542 (0.8); 6.9731 (0.7); 6.9559 (0.8); 6.9404 (0.6); 5.9440 (0.5); 4.9827 (0.7); 4.6648 (1.0); 4.6387 (1.1); 4.6001 (0.6); 4.5834 (0.9); 4.5692 (1.0); 4.5573 (0.8); 4.5440 (0.8); 3.7431 (0.8); 3.7175 (1.4); 3.6883 (1.6); 3.6618 (1.1); 3.2461 (0.8); 3.2119 (1.5); 3.1861 (1.0); 3.1708 (1.2); 3.1445 (0.8); 2.8481 (1.9); 2.7953 (1.9); 2.7712 (5.4); 2.7555 (4.9); 2.7316 (1.3); 2.7140 (1.5); 2.6965 (3.6); 2.6585 (7.5); 2.1085 (1.2); 2.0838 (1.6); 2.0378 (1.4); 2.0170 (1.5); 2.0008 (1.6); 1.9585 (0.7); 1.8846 (0.6); 1.8592 (1.1); 1.8451 (1.1); 1.8313 (1.1); 1.8152 (1.1); 1.7879 (0.8); 1.7499 (0.5); 1.6540 (4.6); 1.6074 (16.0); 1.5919 (2.6); -0.0002 (16.8); -0.0085 (0.5) I.2-46:1H NMR (400.0MHz, CDCl3): δ= 7.5204 (3.5); 7.3764 (1.6); 7.3237 (4.0); 7.3116 (5.6); 7.2616 (452.1); 7.2084 (1.4); 7.1618 (0.9); 7.1485 (1.8); 7.1434 (1.8); 7.1298 (4.4); 7.1085 (3.9); 7.0871 (1.2); 6.9975 (2.6); 5.8317 (1.0); 4.4717 (0.8); 4.4569 (0.8); 4.4347 (2.5); 4.4198 (2.5); 4.4072 (2.4); 4.3925 (2.4); 4.3704 (0.7); 4.3542 (0.7); 3.7090 (1.8); 3.6923 (1.9); 3.6847 (2.2); 3.6675 (2.3); 3.5350 (2.3); 3.5121 (2.8); 3.4890 (1.8); 3.1677 (1.1); 3.1482 (1.2); 3.1343 (2.4); 3.1142 (2.5); 3.0967 (0.7); 3.0855 (2.5); 3.0674 (2.5); 3.0524 (2.3); 3.0341 (2.0); 3.0145 (0.6); 2.7574 (1.1); 2.7368 (1.0); 2.7151 (2.7); 2.6948 (2.5); 2.6732 (2.8); 2.6492 (2.4); 2.6315 (1.0); 2.6074 (0.9); 1.9651 (0.7); 1.9475 (1.1); 1.9303 (1.7); 1.9131 (1.9); 1.8959 (1.7); 1.8787 (1.2); 1.6118 (2.5); 1.5610 (189.7); 1.5084 (0.9); 0.9148 (13.8); 0.9114 (16.0); 0.8982 (13.3); 0.8948 (15.2); 0.1458 (1.0); 0.0495 (1.2); 0.0078 (6.2); -0.0002 (133.1); -0.0083 (5.0); -0.1497 (0.7) I.2-48:1H NMR (400.0MHz, d6-DMSO): δ= 8.6804 (1.2); 8.6657 (2.4); 8.6510 (1.2); 7.6570 (6.6); 7.6542 (8.1); 7.6490 (2.1); 7.6399 (2.4); 7.6374 (4.4); 7.6350 (9.2); 7.6324 (7.8); 7.6266 (0.9); 7.4068 (1.0); 7.4006 (9.5); 7.3955 (4.1); 7.3908 (6.9); 7.3846 (4.9); 7.3792 (16.0); 7.3725 (9.4); 7.3694 (6.4); 7.3641 (1.0); 7.3554 (2.2); 7.3507 (6.7); 7.3452 (0.8); 7.3128 (1.6); 7.3068 (11.4); 7.3014 (3.2); 7.2904 (2.6); 7.2851 (7.2); 7.2790 (0.8); 7.1571 (1.7); 7.1543 (3.4); 7.1515 (1.9); 7.1359 (5.4); 7.1202 (1.4); 7.1174 (2.5); 7.1146 (1.3); 4.3072 (7.8); 4.2924 (7.7); 4.0428 (2.7); 4.0213 (3.9); 4.0186 (4.6); 3.9971 (3.9); 3.9145 (3.9); 3.8991 (4.1); 3.8902 (2.8); 3.8749 (2.9); 3.3373 (0.9); 3.3195 (142.6); 3.3037 (1.4); 3.2980 (2.1); 3.2810 (1.4); 3.2776 (1.1); 3.2747 (1.0); 3.2696 (1.2); 3.2594 (0.8); 2.7896 (2.4); 2.7664 (2.3); 2.7473 (5.5); 2.7241 (5.0); 2.6947 (5.4); 2.6764 (5.2); 2.6699 (0.9); 2.6653 (0.6); 2.6525 (2.3); 2.6341 (2.2); 2.5234 (1.5); 2.5188 (2.2); 2.5100 (33.9); 2.5054 (74.9); 2.5008 (104.6); 2.4962 (72.9); 2.4916 (32.0); 2.4555 (0.6); 2.4510 (0.9); 2.4463 (0.7); 2.3277 (0.7); 0.0081 (1.3); -0.0002 (48.6); -0.0086 (1.4) I.2-49:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.6500 (2.0); 8.6348 (3.7); 8.6205 (2.0); 7.6604 (11.0); 7.6575 (13.6); 7.6524 (3.7); 7.6432 (4.2); 7.6407 (7.7); 7.6383 (15.5); 7.6357 (13.2); 7.6300 (1.7); 7.3960 (1.6); 7.3910 (10.8); 7.3858 (3.4); 7.3780 (2.2); 7.3725 (13.8); 7.3696 (10.9); 7.3643 (2.0); 7.3553 (6.0); 7.3511 (14.1); 7.3455 (1.9); 7.3359 (9.0); 7.3335 (12.2); 7.3311 (9.0); 7.3207 (4.7); 7.3158 (13.7); 7.3141 (10.1); 7.2809 (15.4); 7.2801 (16.0); 7.2745 (3.6); 7.2696 (5.9); 7.2670 (7.2); 7.2647 (8.3); 7.2633 (9.7); 7.2545 (3.1); 7.2489 (6.3); 7.2427 (1.4); 7.2351 (1.4); 7.2313 (2.2); 7.2275 (1.1); 7.1566 (3.0); 7.1539 (5.7); 7.1511 (3.2); 7.1354 (9.0); 7.1197 (2.4); 7.1170 (4.2); 7.1142 (2.2); 4.3235 (13.7); 4.3088 (13.5); 4.0466 (4.6); 4.0251 (6.6); 4.0224 (7.9); 4.0010 (6.8); 3.9226 (6.8); 3.9072 (7.1); 3.8983 (4.9); 3.8830 (5.0); 3.7288 (1.0); 3.3436 (1.3); 3.3189 (235.3); 3.3099 (3.8); 3.3042 (4.0); 3.2875 (2.4); 3.2837 (1.9); 3.2686 (1.7); 3.2655 (1.4); 2.7910 (3.9); 2.7679 (3.6); 2.7488 (9.6); 2.7257 (8.8); 2.7013 (9.4); 2.6830 (8.9); 2.6744 (1.1); 2.6696 (1.4); 2.6650 (1.1); 2.6591 (3.9); 2.6407 (3.5); 2.5231 (2.7); 2.5184 (4.2); 2.5097 (64.8); 2.5051 (142.5); 2.5005 (198.5); 2.4959 (138.8); 2.4913 (61.9); 2.4591 (0.7); 2.4549 (1.1); 2.4502 (1.5); 2.4456 (1.3); 2.3320 (0.9); 2.3273 (1.3); 2.3227 (0.9); 2.0731 (0.5); 0.0080 (2.5); 0.0063 (0.9); -0.0002 (85.7); -0.0060 (1.0); -0.0068 (1.0); -0.0085 (2.6) I.2-50:1H NMR (400.0MHz, d6-DMSO): δ= 8.6437 (0.6); 7.5448 (2.9); 7.5391 (0.9); 7.5277 (0.8); 7.5218 (3.2); 7.3993 (2.3); 7.3942 (0.8); 7.3831 (1.0); 7.3779 (3.7); 7.3030 (2.7); 7.2977 (0.8); 7.2814 (1.8); 6.9447 (3.1); 6.9389 (0.9); 6.9274 (0.8); 6.9217 (2.9); 4.3038 (1.8); 4.2890 (1.8); 3.9913 (0.6); 3.9695 (0.9); 3.9672 (1.1); 3.9455 (0.8); 3.8699 (0.8); 3.8543 (0.9); 3.8457 (0.6); 3.8302 (0.7); 3.7400 (16.0); 3.3119 (17.0); 2.7039 (1.2); 2.6806 (1.1); 2.6610 (1.3); 2.6424 (1.1); 2.5229 (0.7); 2.5182 (1.0); 2.5095 (12.3); 2.5050 (26.7); 2.5003 (37.2); 2.4957 (25.9); 2.4911 (11.5); -0.0002 (5.0) I.2-56:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.6925 (2.2); 8.6775 (4.2); 8.6639 (2.1); 7.6562 (10.8); 7.6533 (12.9); 7.6482 (3.5); 7.6366 (7.7); 7.6342 (14.6); 7.6315 (12.3); 7.6238 (12.7); 7.6187 (12.8); 7.4455 (5.3); 7.4403 (4.6); 7.4247 (10.8); 7.4194 (10.6); 7.3924 (14.1); 7.3903 (16.0); 7.3741 (13.7); 7.3708 (12.6); 7.3573 (3.8); 7.3525 (10.2); 7.1585 (2.9); 7.1557 (5.3); 7.1530 (2.9); 7.1373 (8.4); 7.1216 (2.2); 7.1188 (3.8); 7.1161 (1.9); 4.3612 (12.7); 4.3468 (12.4); 4.0558 (4.2); 4.0343 (6.0); 4.0316 (6.8); 4.0101 (6.0); 3.9225 (6.0); 3.9072 (6.3); 3.8981 (4.3); 3.8829 (4.6); 3.5625 (0.7); 3.5190 (1.0); 3.3778 (1.1); 3.3556 (2.2); 3.3392 (4.0); 3.3185 (567.2); 3.3007 (2.0); 3.2686 (4.7); 2.8035 (3.9); 2.7803 (3.6); 2.7613 (8.3); 2.7380 (7.4); 2.7019 (8.0); 2.6838 (7.6); 2.6746 (2.0); 2.6700 (2.6); 2.6653 (2.0); 2.6597 (4.1); 2.6415 (3.6); 2.5235 (6.3); 2.5188 (9.4); 2.5101 (134.3); 2.5055 (292.0); 2.5009 (405.2); 2.4963 (283.0); 2.4917 (125.6); 2.4601 (1.8); 2.4557 (3.0); 2.4508 (3.6); 2.4463 (2.4); 2.3323 (1.8); 2.3277 (2.4); 2.3231 (1.8); 2.0854 (7.5); 2.0735 (1.6); 1.2358 (1.8); 0.8905 (1.7); 0.8739 (1.8); 0.8523 (0.6); 0.8436 (0.8); 0.8245 (0.8); 0.1461 (0.5); 0.0079 (4.8); -0.0002 (173.4); -0.0068 (2.1); -0.0085 (5.4); -0.0502 (1.2) I.2-58:1H NMR (400.0 MHz, CDCl3): δ= 8.5551 (0.5); 8.5527 (0.6); 8.5509 (0.6); 8.5485 (0.6); 8.5428 (0.6); 8.5404 (0.6); 8.5386 (0.6); 8.5362 (0.5); 7.7139 (0.6); 7.7094 (0.6); 7.6947 (1.0); 7.6902 (1.0); 7.6755 (0.7); 7.6710 (0.7); 7.4853 (3.0); 7.4795 (0.9); 7.4681 (0.9); 7.4623 (3.3); 7.2762 (1.0); 7.2609 (28.2); 7.2568 (1.2); 7.2512 (0.6); 7.2387 (0.5); 7.2323 (0.5); 6.9123 (3.2); 6.9066 (0.9); 6.8951 (0.9); 6.8894 (2.9); 4.6119 (2.3); 4.6003 (2.2); 4.1822 (0.9); 4.1632 (0.9); 4.1581 (1.1); 4.1391 (1.1); 3.9757 (1.1); 3.9541 (1.3); 3.9516 (1.0); 3.9299 (0.9); 3.7980 (16.0); 3.3089 (0.6); 3.3068 (0.6); 3.2876 (0.5); 3.0161 (0.8); 2.9941 (0.7); 2.9738 (1.3); 2.9517 (1.2); 2.8613 (1.3); 2.8376 (1.2); 2.8189 (0.8); 2.7953 (0.7); -0.0002 (12.2) I.2-59:1H NMR (400.0MHz, CDCl3): δ= 8.5583 (3.7); 8.5559 (4.3); 8.5540 (4.5); 8.5516 (3.9); 8.5460 (3.9); 8.5436 (4.5); 8.5417 (4.4); 8.5393 (3.8); 7.7219 (4.0); 7.7174 (4.0); 7.7027 (7.1); 7.6982 (7.1); 7.6835 (4.8); 7.6791 (4.6); 7.6043 (10.8); 7.6014 (13.0); 7.5962 (3.6); 7.5872 (4.1); 7.5848 (7.6); 7.5823 (14.8); 7.5796 (13.2); 7.5739 (1.6); 7.5199 (1.2); 7.3954 (1.7); 7.3904 (10.6); 7.3888 (4.5); 7.3852 (3.5); 7.3772 (2.2); 7.3718 (13.2); 7.3693 (9.8); 7.3638 (1.7); 7.3550 (4.0); 7.3522 (4.1); 7.3503 (10.4); 7.3449 (1.4); 7.2835 (6.9); 7.2610 (218.3); 7.2560 (5.1); 7.2520 (1.2); 7.2512 (1.1); 7.2504 (1.0); 7.2464 (3.9); 7.2449 (3.6); 7.2434 (3.6); 7.2416 (3.0); 7.2399 (3.8); 7.2384 (3.3); 7.2370 (3.2); 7.2275 (3.5); 7.2261 (3.0); 7.2247 (2.9); 7.2112 (1.7); 7.1815 (3.1); 7.1787 (5.8); 7.1758 (3.3); 7.1637 (3.4); 7.1602 (9.0); 7.1583 (4.1); 7.1565 (3.0); 7.1444 (2.8); 7.1416 (4.8); 7.1388 (3.0); 7.1217 (2.1); 6.9970 (1.2); 4.6189 (16.0); 4.6072 (15.9); 4.2258 (6.5); 4.2066 (6.9); 4.2016 (8.1); 4.1824 (8.4); 4.0255 (7.8); 4.0039 (9.2); 4.0013 (7.4); 3.9797 (6.6); 3.3625 (1.4); 3.3401 (3.4); 3.3176 (4.0); 3.2979 (3.6); 3.2759 (1.6); 3.0454 (6.3); 3.0230 (5.2); 3.0029 (9.9); 2.9805 (9.1); 2.8848 (9.8); 2.8612 (9.0); 2.8423 (6.0); 2.8188 (5.4); 1.6779 (4.1); 0.0080 (2.4); -0.0002 (92.6); - 0.0085 (2.7); -0.0499 (0.8) I.2-60:1H NMR (400.0MHz, CDCl3): δ= 7.3113 (0.7); 7.3069 (0.9); 7.2924 (1.0); 7.2905 (1.1); 7.2881 (1.3); 7.2863 (1.3); 7.2718 (1.2); 7.2672 (2.6); 7.2601 (32.4); 7.2472 (1.7); 7.2431 (1.2); 7.1180 (1.3); 7.1122 (1.4); 7.1002 (1.1); 7.0969 (1.7); 7.0918 (0.5); 7.0796 (1.5); 7.0674 (1.0); 7.0657 (0.8); 7.0582 (0.6); 7.0469 (0.7); 7.0120 (1.0); 7.0089 (1.1); 6.9930 (1.4); 6.9899 (1.6); 6.9738 (0.8); 6.9707 (0.9); 6.9651 (1.5); 6.9623 (1.2); 6.9444 (1.3); 6.9415 (1.1); 4.5671 (2.2); 4.5523 (2.1); 3.9973 (1.0); 3.9819 (1.0); 3.9724 (1.5); 3.9570 (1.5); 3.8965 (1.5); 3.8761 (1.7); 3.8717 (1.1); 3.8512 (1.0); 3.7881 (16.0); 3.2466 (0.8); 2.8907 (0.6); 2.8728 (0.6); 2.8483 (1.9); 2.8304 (1.8); 2.8163 (1.9); 2.7929 (1.8); 2.7739 (0.6); 2.7505 (0.6); -0.0002 (12.7) I.2-61:1H NMR (400.0 MHz, CDCl3): δ= 7.5492 (3.1); 7.5434 (1.1); 7.5373 (3.2); 7.5317 (1.8); 7.5262 (3.3); 7.5198 (1.2); 7.5143 (3.2); 7.2596 (103.2); 7.1450 (0.7); 7.1393 (1.4); 7.1345 (0.8); 7.1276 (0.7); 7.1207 (1.2); 7.1155 (2.9); 7.1013 (2.3); 7.0936 (2.0); 7.0825 (1.6); 7.0805 (1.5); 7.0775 (3.8); 7.0722 (1.8); 7.0658 (0.9); 7.0601 (1.6); 7.0569 (4.6); 7.0546 (3.8); 7.0453 (0.6); 7.0397 (1.1); 7.0339 (3.1); 6.9956 (0.6); 5.9914 (0.6); 4.5727 (3.1); 4.5578 (3.0); 4.1673 (1.7); 4.1489 (1.9); 4.1433 (2.2); 4.1249 (2.2); 3.9427 (2.2); 3.9211 (2.6); 3.9186 (2.1); 3.8971 (1.8); 3.1899 (1.0); 3.1715 (1.0); 3.1688 (1.2); 3.1663 (1.2); 3.1478 (1.1); 2.9551 (1.5); 2.9336 (1.2); 2.9127 (2.8); 2.8912 (2.5); 2.8344 (2.8); 2.8105 (2.5); 2.7920 (1.4); 2.7681 (1.2); 1.5434 (16.0); 0.0080 (1.1); -0.0002 (36.1); -0.0085 (1.1) I.2-62:1H NMR (400.0MHz, CDCl3): δ= 7.5551 (0.5); 7.5462 (4.4); 7.5404 (1.5); 7.5343 (4.5); 7.5287 (2.6); 7.5231 (4.8); 7.5170 (1.6); 7.5112 (4.6); 7.4093 (3.2); 7.4038 (1.5); 7.4015 (2.8); 7.3975 (3.8); 7.3960 (3.0); 7.3913 (1.6); 7.3858 (4.4); 7.3769 (0.7); 7.2910 (1.0); 7.2870 (0.6); 7.2798 (5.0); 7.2779 (5.0); 7.2727 (3.0); 7.2679 (4.1); 7.2661 (4.3); 7.2596 (114.1); 7.2557 (8.4); 7.0821 (0.6); 7.0732 (5.1); 7.0673 (1.7); 7.0615 (0.7); 7.0558 (1.8); 7.0526 (5.8); 7.0502 (5.0); 7.0469 (1.7); 7.0412 (0.6); 7.0354 (1.4); 7.0295 (4.4); 6.9956 (0.6); 6.0423 (0.9); 4.5866 (8.5); 4.5718 (8.2); 4.1655 (2.6); 4.1470 (2.7); 4.1414 (3.1); 4.1229 (3.2); 3.9350 (3.0); 3.9135 (3.7); 3.9110 (3.0); 3.8895 (2.6); 3.7847 (1.5); 3.2102 (0.6); 3.1885 (1.4); 3.1700 (1.4); 3.1675 (1.6); 3.1649 (1.6); 3.1464 (1.5); 3.1435 (0.9); 3.1249 (0.7); 2.9576 (2.3); 2.9360 (1.8); 2.9152 (4.0); 2.8936 (3.5); 2.8266 (4.0); 2.8028 (3.5); 2.7842 (2.2); 2.7604 (1.9); 1.5486 (16.0); 0.0079 (1.2); -0.0002 (41.1); -0.0085 (1.3) I.2-63:1H NMR (400.0MHz, CDCl3): δ= 8.5469 (3.9); 8.5444 (4.5); 8.5427 (4.6); 8.5403 (4.0); 8.5346 (4.1); 8.5322 (4.5); 8.5304 (4.4); 8.5280 (3.8); 7.7052 (4.0); 7.7008 (4.0); 7.6860 (7.3); 7.6815 (7.3); 7.6668 (4.8); 7.6624 (4.6); 7.5227 (0.7); 7.2637 (133.3); 7.2439 (8.4); 7.2427 (8.6); 7.2303 (3.7); 7.2289 (3.4); 7.2276 (3.4); 7.2256 (2.8); 7.2239 (3.7); 7.2212 (2.9); 7.2115 (3.3); 7.2102 (3.0); 7.2088 (2.8); 7.0238 (2.2); 6.9997 (1.2); 4.5821 (16.0); 4.5704 (15.7); 4.5374 (1.0); 4.5167 (3.5); 4.4965 (4.7); 4.4765 (2.9); 4.4567 (0.7); 3.6664 (4.3); 3.6481 (4.8); 3.6422 (6.6); 3.6239 (7.0); 3.5586 (6.8); 3.5370 (8.2); 3.5347 (5.6); 3.5128 (5.0); 3.1933 (1.4); 3.1749 (1.8); 3.1719 (3.3); 3.1536 (3.2); 3.1508 (3.9); 3.1480 (3.7); 3.1297 (3.4); 3.1267 (2.1); 3.1084 (1.5); 2.7938 (4.7); 2.7726 (4.2); 2.7520 (9.3); 2.7308 (8.7); 2.6794 (9.8); 2.6554 (9.1); 2.6376 (4.9); 2.6136 (4.4); 2.1074 (1.4); 1.8792 (1.0); 1.8659 (2.1); 1.8619 (2.1); 1.8541 (3.6); 1.8503 (2.8); 1.8456 (2.9); 1.8429 (2.9); 1.8340 (4.2); 1.8228 (2.4); 1.8130 (1.6); 1.8084 (2.0); 1.7278 (0.8); 1.7169 (1.5); 1.7104 (2.1); 1.7041 (2.9); 1.6937 (4.3); 1.6898 (5.0); 1.6821 (4.5); 1.6734 (5.5); 1.6685 (4.7); 1.6522 (3.1); 1.6396 (3.1); 1.6301 (1.6); 1.6207 (2.7); 1.6148 (3.3); 1.6085 (3.1); 1.6061 (3.4); 1.6007 (3.8); 1.5866 (4.6); 1.5783 (5.5); 1.5731 (3.7); 1.5624 (2.5); 1.5521 (2.4); 1.5433 (1.7); 1.5343 (1.6); 1.5222 (1.9); 1.5095 (1.5); 1.5019 (1.8); 1.4912 (1.7); 1.4725 (1.4); 0.0080 (1.4); -0.0002 (51.4); -0.0085 (1.5) I.2-64:1H NMR (400.0 MHz, CDCl3): δ= 8.5566 (4.0); 8.5524 (4.7); 8.5499 (4.2); 8.5443 (4.3); 8.5419 (4.8); 8.5377 (4.1); 7.7210 (3.9); 7.7165 (3.9); 7.7018 (7.3); 7.6974 (7.0); 7.6826 (4.8); 7.6781 (4.6); 7.5810 (1.0); 7.5720 (10.6); 7.5663 (3.9); 7.5601 (11.2); 7.5545 (6.7); 7.5489 (12.2); 7.5428 (4.3); 7.5370 (11.8); 7.5281 (1.5); 7.5191 (1.9); 7.2796 (7.3); 7.2602 (304.7); 7.2461 (5.8); 7.2448 (5.4); 7.2434 (5.4); 7.2414 (4.7); 7.2396 (5.2); 7.2370 (4.5); 7.2273 (4.6); 7.1111 (2.3); 7.0899 (2.1); 7.0811 (12.8); 7.0752 (4.2); 7.0693 (2.1); 7.0637 (5.1); 7.0604 (14.4); 7.0579 (12.9); 7.0546 (4.6); 7.0489 (1.9); 7.0431 (4.1); 7.0372 (11.3); 7.0283 (1.3); 6.9962 (1.8); 4.6152 (16.0); 4.6036 (16.0); 4.2000 (6.3); 4.1813 (6.9); 4.1760 (7.8); 4.1573 (8.1); 3.9926 (7.6); 3.9710 (9.3); 3.9686 (7.4); 3.9470 (6.6); 3.3593 (1.4); 3.3375 (3.5); 3.3187 (3.6); 3.3165 (3.9); 3.3142 (3.9); 3.2954 (3.7); 3.2924 (2.3); 3.2737 (1.6); 3.0282 (5.7); 3.0064 (4.8); 2.9857 (9.5); 2.9638 (8.7); 2.8820 (9.5); 2.8583 (8.8); 2.8394 (5.6); 2.8158 (5.0); 1.6538 (2.2); 1.2553 (0.9); 0.0079 (4.0); -0.0002 (109.2); -0.0085 (3.6) I.2-65:1H NMR (600.1MHz, CD3CN): δ= 8.5099 (4.8); 8.5088 (4.9); 8.5019 (5.0); 8.5008 (4.9); 7.7267 (3.6); 7.7237 (3.7); 7.7139 (6.9); 7.7109 (6.9); 7.7011 (4.1); 7.6981 (4.1); 7.2815 (7.2); 7.2684 (6.8); 7.2333 (3.7); 7.2324 (3.8); 7.2315 (3.6); 7.2252 (3.8); 7.2243 (4.0); 7.2234 (3.9); 7.2219 (3.2); 7.2208 (4.0); 7.2199 (3.9); 7.2190 (3.6); 7.2127 (3.6); 7.2118 (3.7); 7.2109 (3.4); 7.1179 (1.5); 4.5484 (0.9); 4.5338 (2.3); 4.5197 (4.1); 4.5061 (2.4); 4.5043 (2.4); 4.4904 (1.1); 4.4543 (16.0); 4.4447 (15.9); 3.6815 (5.3); 3.6657 (8.5); 3.6511 (7.3); 3.5582 (6.7); 3.5478 (7.1); 3.5422 (5.4); 3.5318 (5.5); 3.1796 (1.7); 3.1692 (1.9); 3.1668 (2.3); 3.1647 (3.0); 3.1564 (2.3); 3.1540 (3.3); 3.1521 (3.4); 3.1500 (2.5); 3.1414 (2.9); 3.1396 (2.4); 3.1372 (2.0); 3.1267 (1.6); 2.5327 (1.4); 2.5199 (1.7); 2.5049 (12.6); 2.4985 (13.0); 2.4922 (12.0); 2.4831 (12.1); 2.4707 (1.5); 2.4554 (1.7); 2.2529 (0.8); 2.2505 (0.6); 2.2474 (0.9); 2.2404 (0.7); 2.2365 (2.6); 2.2336 (2.6); 2.2311 (3.3); 2.2243 (1.7); 2.2198 (3.5); 2.2175 (4.6); 2.2145 (4.6); 2.2124 (3.9); 2.2080 (1.9); 2.2011 (3.5); 2.1981 (3.0); 2.1954 (2.9); 2.1845 (1.2); 2.1814 (0.8); 2.1790 (1.1); 2.1385 (85.9); 2.0632 (0.4); 2.0606 (0.4); 2.0572 (1.0); 2.0540 (1.2); 2.0499 (2.6); 2.0459 (3.4); 2.0441 (3.2); 2.0419 (2.1); 2.0382 (4.6); 2.0331 (5.2); 2.0313 (4.5); 2.0262 (5.2); 2.0206 (4.1); 2.0185 (3.4); 2.0138 (3.4); 2.0080 (1.8); 2.0058 (1.3); 2.0035 (1.0); 2.0011 (1.1); 1.9952 (0.4); 1.9633 (8.2); 1.9552 (8.9); 1.9511 (10.1); 1.9472 (58.1); 1.9432 (102.5); 1.9390 (148.1); 1.9349 (100.8); 1.9308 (50.4); 1.9220 (1.0); 1.8281 (0.6); 1.8240 (0.8); 1.8199 (0.6); 1.7218 (0.5); 1.7093 (0.7); 1.7040 (1.8); 1.6914 (3.2); 1.6868 (3.8); 1.6822 (2.2); 1.6805 (2.8); 1.6744 (5.8); 1.6694 (3.4); 1.6662 (4.2); 1.6646 (4.6); 1.6629 (4.0); 1.6608 (2.9); 1.6593 (2.9); 1.6575 (3.2); 1.6551 (1.4); 1.6532 (1.6); 1.6502 (2.2); 1.6486 (2.6); 1.6465 (2.3); 1.6445 (1.5); 1.6431 (1.3); 1.6370 (0.3); 1.6322 (0.4); 1.6307 (0.3); -0.0001 (10.2); -0.0057 (0.4) I.2-66:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.6963 (1.2); 8.6821 (2.1); 8.6681 (1.0); 7.7120 (1.2); 7.7041 (10.6); 7.6985 (3.0); 7.6869 (3.6); 7.6813 (12.6); 7.6733 (1.1); 7.6591 (2.0); 7.6522 (3.7); 7.6452 (2.1); 7.5111 (2.2); 7.5087 (4.3); 7.5045 (2.8); 7.4907 (2.9); 7.4865 (6.1); 7.4842 (2.7); 7.4643 (2.8); 7.4599 (1.0); 7.4429 (5.4); 7.4400 (16.0); 7.4345 (3.5); 7.4228 (3.6); 7.4174 (12.2); 7.4091 (1.3); 7.4006 (14.9); 7.3965 (4.0); 7.3825 (3.7); 7.3760 (1.8); 7.3650 (2.1); 7.3585 (1.4); 7.3441 (2.8); 7.3376 (2.6); 7.3231 (0.9); 7.3165 (1.0); 4.3713 (6.6); 4.3571 (6.4); 4.2897 (0.5); 4.2746 (0.6); 4.0594 (2.2); 4.0379 (3.7); 4.0351 (3.8); 4.0137 (3.7); 3.9168 (2.9); 3.9020 (3.0); 3.8925 (2.1); 3.8778 (2.3); 3.8265 (6.8); 3.3225 (62.5); 2.8283 (2.2); 2.8050 (2.2); 2.7860 (3.8); 2.7625 (3.4); 2.6962 (3.7); 2.6789 (4.2); 2.6748 (2.1); 2.6701 (2.6); 2.6655 (1.8); 2.6538 (1.9); 2.6364 (1.9); 2.5508 (0.9); 2.5348 (1.3); 2.5237 (7.6); 2.5190 (10.5); 2.5103 (143.4); 2.5057 (315.4); 2.5010 (445.4); 2.4964 (310.1); 2.4918 (136.1); 2.4600 (2.6); 2.4556 (4.1); 2.4511 (5.1); 2.4465 (3.8); 2.4065 (0.7); 2.3324 (2.1); 2.3279 (2.8); 2.3232 (2.0); 2.0734 (1.1); 1.4995 (1.5); 1.4767 (3.0); 0.9406 (2.0); 0.9264 (2.9); 0.9232 (3.8); 0.9051 (1.3); 0.8826 (0.6); 0.8583 (0.8); -0.0002 (10.5) I.2-67:1H NMR (400.0MHz, d6-DMSO): δ= 8.7285 (1.5); 8.7136 (2.7); 8.6995 (1.4); 8.3359 (5.4); 8.3311 (5.1); 7.7665 (3.9); 7.7602 (3.7); 7.7459 (4.4); 7.7396 (4.2); 7.7120 (1.5); 7.7039 (13.0); 7.6984 (3.9); 7.6868 (4.3); 7.6812 (15.3); 7.6732 (1.3); 7.4994 (7.1); 7.4775 (5.9); 7.4437 (1.8); 7.4358 (16.0); 7.4303 (4.1); 7.4186 (3.8); 7.4131 (13.1); 7.4051 (1.0); 5.7554 (1.1); 4.3365 (8.3); 4.3220 (8.2); 4.0297 (2.6); 4.0054 (4.5); 3.9838 (3.7); 3.8975 (3.8); 3.8823 (4.1); 3.8732 (2.8); 3.8580 (2.8); 3.3701 (1.0); 3.3187 (399.0); 3.2906 (2.9); 3.2690 (4.0); 3.2517 (0.9); 3.2189 (0.5); 2.7965 (2.5); 2.7732 (2.3); 2.7540 (5.0); 2.7308 (4.7); 2.6924 (5.3); 2.6745 (6.8); 2.6699 (3.4); 2.6655 (2.2); 2.6500 (2.2); 2.6320 (2.4); 2.5556 (1.3); 2.5234 (8.8); 2.5187 (12.8); 2.5101 (164.1); 2.5055 (357.8); 2.5009 (501.3); 2.4963 (353.8); 2.4917 (160.4); 2.4556 (3.5); 2.4512 (3.8); 2.4011 (1.0); 2.3323 (2.4); 2.3277 (3.2); 2.3230 (2.3); 2.0735 (1.6); 0.0080 (2.5); -0.0002 (92.6); -0.0085 (3.0); -0.0499 (0.6) I.2-68:1H NMR (400.0 MHz, CDCl3): δ= 7.5195 (1.6); 7.4057 (3.9); 7.3958 (1.5); 7.3915 (5.0); 7.3827 (8.0); 7.3706 (18.8); 7.3649 (20.2); 7.3470 (5.4); 7.3284 (16.9); 7.3071 (28.4); 7.2607 (270.8); 7.2485 (15.5); 7.2422 (13.8); 7.2271 (9.0); 7.2209 (8.2); 6.9966 (1.6); 6.9373 (3.3); 6.9346 (2.0); 6.9301 (5.2); 6.9276 (6.5); 6.9238 (6.7); 6.9178 (9.2); 6.9154 (5.3); 6.9102 (10.4); 6.9082 (10.8); 6.9028 (8.2); 6.8968 (13.2); 6.8904 (10.4); 6.8836 (2.1); 6.8762 (6.6); 6.8694 (4.0); 6.1072 (3.8); 4.5768 (1.2); 4.5618 (1.2); 4.5392 (15.9); 4.5337 (16.0); 4.5242 (15.6); 4.5186 (15.6); 4.4963 (1.1); 4.4811 (1.1); 4.0477 (5.9); 4.0296 (6.5); 4.0236 (9.3); 4.0056 (9.4); 3.9395 (10.3); 3.9180 (12.2); 3.8943 (7.2); 3.2999 (2.2); 3.2790 (5.3); 3.2609 (5.3); 3.2582 (6.8); 3.2555 (6.1); 3.2375 (5.6); 3.2167 (2.4); 2.9298 (8.6); 2.9092 (7.5); 2.8872 (15.3); 2.8666 (14.2); 2.8004 (15.0); 2.7768 (13.9); 2.7579 (8.1); 2.7343 (7.3); 1.5678 (4.4); 1.2577 (0.8); 0.0079 (3.2); -0.0002 (101.3); - 0.0085 (2.9) I.2-69:1H NMR (400.0 MHz, CDCl3): δ= 8.7236 (2.9); 7.9669 (3.1); 7.9655 (3.2); 7.9620 (3.1); 7.5196 (1.4); 7.3110 (0.8); 7.2775 (0.6); 7.2767 (0.7); 7.2751 (0.8); 7.2744 (0.8); 7.2727 (1.0); 7.2720 (1.2); 7.2711 (1.2); 7.2687 (2.4); 7.2680 (2.5); 7.2672 (2.8); 7.2663 (3.3); 7.2655 (4.2); 7.2647 (5.2); 7.2607 (255.0); 7.2566 (2.5); 7.2557 (1.4); 7.2549 (1.1); 7.2541 (0.8); 7.2533 (0.5); 7.2105 (1.8); 7.0812 (0.9); 6.9967 (1.4); 4.7451 (4.0); 4.7344 (3.9); 3.7383 (1.9); 3.7211 (2.1); 3.7139 (2.6); 3.6966 (2.7); 3.5906 (2.7); 3.5689 (3.3); 3.5662 (2.4); 3.5444 (2.3); 3.2811 (0.5); 3.2602 (0.9); 3.2394 (1.4); 3.2187 (1.0); 3.2149 (0.7); 3.1977 (0.5); 3.1758 (0.8); 3.1564 (0.8); 3.1421 (2.5); 3.1226 (2.6); 3.1111 (2.4); 3.0928 (2.4); 3.0773 (0.8); 3.0588 (0.8); 2.8336 (1.1); 2.8137 (1.0); 2.7918 (2.6); 2.7716 (2.5); 2.7404 (2.5); 2.7160 (2.3); 2.6980 (1.0); 2.6737 (0.9); 2.1370 (0.6); 1.9670 (0.5); 1.9487 (1.0); 1.9318 (1.4); 1.9151 (1.1); 1.8961 (0.6); 1.5825 (3.0); 0.9278 (16.0); 0.9245 (16.0); 0.9111 (15.9); 0.9078 (15.6); 0.0079 (3.4); 0.0064 (0.9); 0.0055 (1.0); 0.0047 (1.3); -0.0002 (109.2); -0.0051 (1.4); -0.0059 (1.2); -0.0068 (1.0); -0.0085 (3.1); -0.0504 (0.8) I.2-70:1H NMR (400.0MHz, CDCl3): δ= 8.7233 (11.7); 8.7207 (11.6); 7.9672 (13.0); 7.9658 (13.2); 7.9623 (12.9); 7.9610 (12.2); 7.5198 (4.3); 7.3111 (2.0); 7.2834 (1.1); 7.2785 (1.8); 7.2746 (2.4); 7.2706 (4.1); 7.2610 (763.5); 7.2569 (5.6); 7.2560 (3.4); 7.2552 (2.2); 7.2544 (1.7); 7.2536 (1.2); 7.2527 (1.4); 7.2520 (1.3); 7.2504 (0.9); 7.2496 (0.8); 7.2488 (0.8); 7.2109 (6.9); 7.1610 (0.7); 7.0886 (4.1); 6.9969 (4.5); 4.7429 (15.6); 4.7318 (15.3); 4.6851 (0.6); 4.5543 (1.5); 4.5333 (5.4); 4.5131 (7.2); 4.4930 (4.4); 4.4733 (1.1); 3.6977 (6.5); 3.6799 (7.4); 3.6734 (10.0); 3.6556 (10.7); 3.5894 (10.2); 3.5680 (12.4); 3.5654 (8.2); 3.5437 (7.6); 3.2522 (2.1); 3.2314 (4.7); 3.2136 (4.5); 3.2105 (5.9); 3.2074 (5.3); 3.1895 (4.7); 3.1864 (3.1); 3.1685 (2.1); 2.8173 (6.3); 2.7966 (5.7); 2.7755 (15.2); 2.7548 (14.2); 2.7268 (16.0); 2.7028 (15.1); 2.6850 (6.6); 2.6611 (6.0); 2.1370 (0.8); 1.8691 (5.2); 1.8600 (4.6); 1.8490 (6.1); 1.8238 (3.1); 1.7157 (3.8); 1.7056 (5.6); 1.7012 (6.9); 1.6936 (5.1); 1.6857 (5.8); 1.6800 (4.4); 1.6638 (3.5); 1.6520 (5.2); 1.6277 (8.4); 1.6189 (9.8); 1.6129 (10.3); 1.6024 (9.4); 1.5915 (9.9); 1.5652 (4.2); 1.5377 (3.2); 1.5179 (2.9); 1.5070 (2.7); 1.4884 (2.1); 1.4376 (1.0); 1.4190 (1.7); 1.4006 (0.9); 1.2562 (0.6); 0.1461 (0.9); 0.0690 (2.7); 0.0499 (0.6); 0.0080 (8.8); -0.0002 (343.2); -0.0085 (9.8); -0.0503 (3.3); -0.1498 (0.9) I.2-71:1H NMR (400.0 MHz, CDCl3): δ= 7.5189 (1.1); 7.4090 (1.8); 7.3943 (2.1); 7.3860 (3.3); 7.3712 (3.2); 7.3652 (2.2); 7.3503 (2.2); 7.3101 (0.5); 7.2928 (0.8); 7.2912 (0.8); 7.2888 (0.9); 7.2857 (1.1); 7.2832 (1.2); 7.2816 (1.4); 7.2808 (1.4); 7.2800 (1.5); 7.2792 (1.5); 7.2784 (1.6); 7.2776 (1.7); 7.2768 (1.8); 7.2761 (1.8); 7.2752 (1.9); 7.2745 (2.0); 7.2737 (2.1); 7.2729 (2.2); 7.2721 (2.3); 7.2713 (2.4); 7.2704 (2.7); 7.2697 (2.8); 7.2689 (3.0); 7.2681 (3.3); 7.2672 (3.7); 7.2601 (191.3); 7.2544 (3.2); 7.2535 (2.4); 7.2527 (1.9); 7.2519 (1.5); 7.2511 (1.1); 7.2503 (1.0); 7.2495 (0.8); 7.2487 (0.7); 7.2479 (0.6); 7.1588 (0.9); 7.1535 (1.0); 7.1394 (1.8); 7.1337 (3.4); 7.1288 (2.2); 7.1222 (2.1); 7.1152 (3.1); 7.1097 (6.6); 7.0955 (5.9); 7.0886 (5.1); 7.0776 (3.4); 7.0758 (2.9); 7.0677 (2.5); 7.0640 (1.4); 7.0583 (1.1); 7.0533 (1.3); 7.0482 (0.7); 7.0393 (0.5); 7.0362 (0.6); 6.9960 (1.1); 6.9381 (1.6); 6.9355 (1.1); 6.9311 (2.4); 6.9285 (3.0); 6.9245 (3.1); 6.9186 (4.0); 6.9162 (2.6); 6.9111 (4.5); 6.9091 (4.7); 6.9035 (3.5); 6.8974 (5.6); 6.8913 (4.4); 6.8845 (0.9); 6.8764 (2.6); 6.8702 (1.6); 5.9992 (1.7); 4.5669 (8.4); 4.5520 (8.0); 4.0427 (2.5); 4.0234 (2.9); 4.0185 (4.0); 4.0006 (3.9); 3.9342 (4.3); 3.9124 (5.2); 3.8889 (3.0); 3.2770 (1.0); 3.2562 (2.4); 3.2381 (2.4); 3.2354 (3.0); 3.2327 (2.6); 3.2147 (2.4); 3.1939 (1.0); 2.9285 (3.7); 2.9080 (3.2); 2.8860 (6.4); 2.8654 (5.9); 2.7943 (6.3); 2.7707 (5.8); 2.7518 (3.5); 2.7282 (3.1); 1.5464 (16.0); 1.2583 (0.5); 0.0144 (0.7); 0.0136 (0.8); 0.0080 (2.9); 0.0064 (1.8); -0.0002 (75.2); -0.0085 (2.4) I.2-72:1H NMR (400.0MHz, d6-DMSO): δ= 8.7179 (3.3); 8.7035 (5.9); 8.6903 (3.4); 7.6190 (12.0); 7.4690 (3.9); 7.4478 (10.2); 7.4344 (9.8); 7.4154 (16.0); 7.3944 (4.4); 7.3667 (2.2); 7.3474 (4.5); 7.3276 (4.9); 7.3218 (5.2); 7.3080 (3.3); 7.2312 (14.4); 7.2170 (2.8); 7.2058 (2.9); 7.1965 (5.8); 7.1855 (7.5); 7.1782 (9.3); 7.1704 (10.1); 7.0461 (6.8); 6.9611 (5.6); 6.9415 (5.5); 4.3919 (13.8); 4.3780 (14.1); 4.0521 (4.4); 4.0285 (8.4); 4.0061 (5.8); 3.9090 (5.9); 3.8939 (6.3); 3.8838 (5.8); 3.8697 (5.3); 3.3226 (25.2); 2.8171 (4.0); 2.7938 (3.8); 2.7746 (7.5); 2.7512 (6.9); 2.6931 (7.7); 2.6753 (9.2); 2.6510 (4.5); 2.6332 (4.3); 2.5043 (449.7); 2.5001 (613.5); 2.4958 (479.2); 2.3270 (3.8); 1.4336 (2.0); 1.1642 (0.6); 0.9077 (1.8); 0.8898 (2.4); 0.1458 (0.9); -0.0002 (190.4); -0.1496 (0.9) I.2-73:1H NMR (400.0MHz, CDCl3): δ= 7.8781 (4.0); 7.8571 (4.6); 7.8297 (8.2); 7.5184 (5.0); 7.5098 (3.3); 7.4907 (7.0); 7.4700 (4.6); 7.4229 (9.6); 7.4035 (4.1); 7.3946 (10.8); 7.3884 (11.5); 7.3417 (10.4); 7.3204 (16.9); 7.2935 (4.6); 7.2726 (8.6); 7.2596 (873.2); 7.2412 (5.9); 7.2350 (5.1); 7.1899 (2.8); 7.1836 (2.6); 7.1694 (1.7); 7.1628 (1.6); 6.9956 (4.6); 6.0424 (2.3); 4.5950 (0.9); 4.5580 (11.2); 4.5432 (10.7); 4.5401 (10.6); 4.2300 (5.9); 4.2116 (6.3); 4.2060 (7.3); 4.1875 (7.4); 4.0165 (6.6); 3.9950 (8.4); 3.9925 (6.7); 3.9710 (5.8); 3.9238 (9.6); 3.2502 (1.3); 3.2287 (3.2); 3.2077 (4.0); 3.1866 (3.6); 3.1651 (1.4); 2.9974 (5.2); 2.9759 (4.0); 2.9547 (10.0); 2.9332 (8.8); 2.8842 (9.9); 2.8604 (8.7); 2.8415 (4.7); 2.8178 (4.3); 2.0453 (1.1); 1.5654 (16.0); 1.2837 (1.0); 1.2565 (2.0); 0.1458 (1.0); 0.0079 (10.1); -0.0002 (335.2); -0.0085 (9.6); -0.1495 (1.1) I.2-74:1H NMR (400.0MHz, d6-DMSO): δ= 8.7153 (3.8); 8.7013 (6.2); 8.6868 (3.4); 7.9615 (11.1); 7.7503 (6.2); 7.7295 (6.8); 7.5418 (5.7); 7.5221 (10.5); 7.5023 (5.6); 7.3732 (2.2); 7.3665 (2.8); 7.3469 (9.8); 7.3215 (8.8); 7.3077 (2.3); 7.2174 (2.4); 7.1978 (6.1); 7.1851 (10.3); 7.1810 (8.9); 7.1736 (14.0); 7.1617 (6.7); 7.1461 (2.0); 7.0339 (15.3); 6.8945 (7.6); 4.3958 (16.0); 4.3815 (15.7); 4.0807 (5.9); 4.0566 (10.0); 4.0351 (8.0); 3.9381 (8.2); 3.9231 (8.9); 3.9139 (6.4); 3.8990 (6.3); 3.3588 (6.3); 3.3075 (657.4); 3.2827 (2.6); 3.2582 (4.8); 2.8238 (5.9); 2.8005 (5.5); 2.7813 (11.2); 2.7581 (10.3); 2.7044 (11.7); 2.6868 (10.8); 2.6739 (6.8); 2.6692 (10.1); 2.6622 (8.3); 2.6444 (6.2); 2.5551 (13.6); 2.5505 (14.7); 2.5456 (14.4); 2.5227 (65.2); 2.5179 (83.1); 2.5093 (562.0); 2.5048 (1152.6); 2.5002 (1565.7); 2.4956 (1106.5); 2.4910 (506.6); 2.4688 (3.6); 2.4554 (7.4); 2.4507 (9.0); 2.4460 (6.2); 2.3997 (1.8); 2.3317 (6.8); 2.3270 (9.2); 2.3224 (6.6); 1.2339 (1.5); 0.1458 (2.2); 0.0498 (3.1); 0.0080 (24.0); -0.0002 (669.3); -0.0085 (22.5); -0.0326 (1.3); -0.0497 (4.0); -0.1495 (2.2) I.2-75:1H NMR (400.0 MHz, CDCl3): δ= 7.5021 (0.8); 7.4967 (1.6); 7.4912 (0.9); 7.4202 (0.6); 7.4129 (1.4); 7.4057 (1.1); 7.4002 (1.9); 7.3967 (1.4); 7.3943 (1.7); 7.3918 (2.0); 7.3603 (1.3); 7.3400 (1.9); 7.3195 (0.8); 7.2839 (1.8); 7.2823 (1.8); 7.2769 (1.1); 7.2724 (1.5); 7.2705 (1.6); 7.2662 (1.6); 7.2595 (79.6); 6.9288 (0.6); 6.9088 (0.6); 6.7030 (1.3); 6.5184 (2.6); 6.3338 (1.3); 4.5912 (3.2); 4.5763 (3.1); 4.1732 (0.9); 4.1545 (0.9); 4.1490 (1.1); 4.1304 (1.1); 3.9622 (1.0); 3.9406 (1.3); 3.9382 (1.0); 3.9165 (0.9); 3.1872 (0.5); 3.1640 (0.6); 3.1451 (0.6); 2.9825 (0.9); 2.9607 (0.6); 2.9399 (1.5); 2.9181 (1.2); 2.8436 (1.4); 2.8199 (1.3); 2.8010 (0.8); 2.7773 (0.7); 1.5385 (16.0); 0.0080 (0.9); -0.0002 (27.6); -0.0085 (0.8) I.2-76:1H NMR (400.0MHz, d6-DMSO): δ= 8.3883 (1.5); 8.3768 (2.9); 8.3657 (1.5); 7.6210 (5.6); 7.6159 (3.5); 7.5178 (8.9); 7.5163 (9.0); 7.4970 (16.0); 7.4620 (1.1); 7.4562 (1.6); 7.4514 (1.2); 7.4394 (4.2); 7.4352 (7.4); 7.4307 (8.3); 7.4169 (5.0); 7.4128 (6.0); 7.4003 (6.9); 7.3922 (2.1); 7.3818 (5.4); 7.3786 (4.9); 7.3601 (4.0); 7.2318 (9.1); 7.0467 (4.6); 6.9590 (2.6); 6.9532 (1.8); 6.9405 (2.6); 5.7530 (1.8); 4.5530 (6.1); 4.5497 (6.2); 4.5414 (6.1); 4.5381 (6.1); 4.4836 (0.6); 4.4707 (0.6); 4.0187 (2.1); 3.9944 (3.9); 3.9729 (3.1); 3.8856 (3.2); 3.8713 (3.3); 3.8613 (2.4); 3.8469 (2.4); 3.3091 (134.7); 3.2587 (2.3); 3.2433 (1.3); 3.2356 (1.2); 3.2216 (0.8); 2.7826 (2.3); 2.7592 (2.2); 2.7401 (4.4); 2.7167 (4.0); 2.6739 (2.8); 2.6692 (4.2); 2.6645 (7.1); 2.6472 (4.3); 2.6219 (2.4); 2.6047 (2.5); 2.5454 (1.6); 2.5227 (10.8); 2.5180 (15.8); 2.5094 (211.5); 2.5048 (459.9); 2.5002 (640.4); 2.4956 (457.2); 2.4910 (210.2); 2.3316 (2.7); 2.3270 (3.7); 2.3224 (2.7); 2.3179 (1.3); 2.0721 (1.0); 1.3578 (6.4); 0.8659 (0.7); 0.1461 (1.3); 0.0080 (10.2); -0.0002 (344.1); -0.0085 (10.9); -0.1497 (1.3) I.2-77:1H NMR (400.0MHz, d6-DMSO): δ= 8.3899 (1.4); 8.3787 (2.7); 8.3676 (1.4); 7.9616 (4.2); 7.7397 (2.1); 7.7369 (2.0); 7.7216 (2.0); 7.7190 (2.6); 7.7162 (2.6); 7.5366 (3.1); 7.5161 (13.3); 7.4970 (16.0); 7.4805 (0.8); 7.4624 (1.4); 7.4591 (1.7); 7.4434 (1.3); 7.4381 (1.1); 7.4189 (1.7); 7.4004 (7.5); 7.3819 (5.1); 7.3787 (5.5); 7.3602 (3.8); 7.3421 (3.4); 7.3344 (1.4); 7.3225 (2.6); 7.3160 (1.2); 7.3126 (0.8); 7.2940 (0.5); 7.1743 (2.8); 7.0348 (6.0); 6.8953 (2.9); 4.5556 (7.8); 4.5439 (7.7); 4.2285 (0.5); 4.2090 (0.6); 4.1039 (5.4); 4.0482 (2.3); 4.0265 (3.5); 4.0242 (4.0); 4.0027 (3.1); 3.9130 (3.2); 3.8985 (3.3); 3.8888 (2.4); 3.8744 (2.5); 3.6012 (0.5); 3.4936 (0.7); 3.3127 (0.8); 3.2955 (1.2); 3.2906 (1.3); 3.2810 (1.2); 3.2745 (2.0); 3.2587 (1.3); 3.2533 (1.1); 3.2364 (0.7); 2.7891 (2.1); 2.7658 (2.0); 2.7467 (4.2); 2.7234 (3.8); 2.6776 (4.4); 2.6696 (1.3); 2.6604 (4.2); 2.6351 (2.0); 2.6179 (1.9); 2.5231 (2.7); 2.5184 (3.9); 2.5097 (53.4); 2.5051 (116.3); 2.5005 (163.1); 2.4959 (116.3); 2.4914 (53.3); 2.3320 (0.7); 2.3273 (1.0); 2.3227 (0.7); 1.4582 (0.9); 1.4226 (0.5); 0.9357 (0.5); 0.9192 (1.1); 0.9094 (0.8); 0.8887 (1.1); 0.8855 (1.0); 0.8705 (2.2); 0.8673 (2.2); 0.8524 (1.6); 0.8492 (1.7); 0.0080 (3.0); -0.0002 (98.2); -0.0085 (2.9) I.2-78:1H NMR (400.0 MHz, CDCl3): δ= 7.5184 (0.7); 7.4085 (1.4); 7.3981 (1.7); 7.3935 (2.6); 7.3850 (2.3); 7.3824 (2.1); 7.3700 (1.0); 7.3637 (0.7); 7.3488 (0.6); 7.2881 (0.6); 7.2765 (2.6); 7.2695 (2.1); 7.2596 (129.6); 7.2531 (4.0); 6.9956 (0.7); 6.9256 (0.8); 6.9220 (0.8); 6.9156 (1.0); 6.9062 (1.3); 6.9009 (1.0); 6.8948 (1.5); 6.8882 (1.2); 6.8739 (0.8); 4.5857 (4.1); 4.5709 (4.0); 4.0456 (0.7); 4.0272 (0.8); 4.0220 (1.1); 4.0037 (1.1); 3.9303 (1.3); 3.9089 (1.5); 3.8850 (0.9); 3.2560 (0.6); 3.2351 (0.8); 3.2144 (0.7); 2.9371 (1.1); 2.9164 (0.9); 2.8946 (1.8); 2.8739 (1.7); 2.7921 (1.8); 2.7686 (1.6); 2.7496 (1.0); 2.7260 (0.9); 1.5369 (16.0); 0.0079 (1.5); - 0.0002 (45.8); -0.0084 (1.4) I.2-79:1H NMR (400.0 MHz, CDCl3): δ= 7.5562 (1.4); 7.5473 (10.2); 7.5415 (3.9); 7.5354 (10.5); 7.5299 (6.3); 7.5243 (11.0); 7.5184 (5.4); 7.5124 (10.4); 7.5035 (1.1); 7.3655 (14.8); 7.3449 (25.1); 7.3084 (0.8); 7.2886 (1.4); 7.2597 (361.7); 7.2414 (10.0); 7.2228 (8.3); 7.2198 (7.1); 7.2012 (5.5); 7.0815 (1.4); 7.0726 (11.2); 7.0668 (3.7); 7.0609 (2.2); 7.0551 (5.0); 7.0520 (13.5); 7.0496 (11.6); 7.0462 (4.1); 7.0406 (1.7); 7.0347 (3.5); 7.0289 (9.8); 7.0201 (0.8); 6.9957 (1.9); 5.8324 (2.3); 4.8656 (0.6); 4.8524 (0.7); 4.8306 (11.8); 4.8272 (11.3); 4.8170 (11.2); 4.8135 (10.9); 4.7921 (0.6); 4.7783 (0.6); 4.6906 (0.7); 4.1869 (5.7); 4.1683 (6.3); 4.1628 (7.0); 4.1442 (6.9); 3.9275 (6.7); 3.9059 (8.4); 3.9036 (6.8); 3.8819 (5.9); 3.1923 (1.1); 3.1706 (3.2); 3.1519 (3.5); 3.1495 (3.9); 3.1469 (3.7); 3.1283 (3.6); 3.1067 (1.5); 2.9666 (5.4); 2.9449 (4.1); 2.9241 (8.7); 2.9024 (7.6); 2.8179 (8.4); 2.7940 (7.6); 2.7754 (4.9); 2.7516 (4.4); 2.6512 (0.8); 1.9903 (0.9); 1.5446 (16.0); 1.2559 (1.2); 1.1636 (0.7); 0.0079 (4.8); -0.0002 (129.2); -0.0085 (4.0) I.2-80:1H NMR (400.0MHz, CDCl3): δ= 7.5187 (0.8); 7.5073 (1.3); 7.5018 (2.6); 7.4965 (1.5); 7.4228 (0.9); 7.4202 (1.0); 7.4177 (0.8); 7.4150 (0.8); 7.4021 (1.7); 7.3995 (1.8); 7.3970 (1.7); 7.3943 (1.5); 7.3884 (2.7); 7.3821 (2.9); 7.3657 (2.2); 7.3454 (3.3); 7.3390 (2.7); 7.3249 (1.4); 7.3178 (4.4); 7.2598 (150.3); 7.2536 (3.1); 7.2382 (1.4); 7.2320 (1.3); 6.9958 (0.8); 6.9344 (1.0); 6.9310 (1.0); 6.9147 (0.9); 6.9110 (0.9); 6.7062 (2.4); 6.5217 (4.8); 6.3371 (2.5); 6.0477 (0.6); 4.5531 (2.6); 4.5494 (2.6); 4.5381 (2.5); 4.5343 (2.6); 4.1823 (1.5); 4.1637 (1.6); 4.1581 (1.9); 4.1395 (1.9); 3.9776 (1.8); 3.9560 (2.2); 3.9534 (1.7); 3.9319 (1.5); 3.2103 (0.8); 3.1892 (1.0); 3.1681 (0.9); 2.9825 (1.4); 2.9607 (1.1); 2.9399 (2.5); 2.9181 (2.3); 2.8615 (2.5); 2.8378 (2.2); 2.8190 (1.3); 2.7952 (1.1); 1.5440 (16.0); 0.0080 (1.6); -0.0002 (52.8); -0.0085 (1.4) I.2-81:1H NMR (400.0 MHz, CDCl3): δ= 7.4144 (0.7); 7.4091 (0.7); 7.3598 (0.6); 7.3390 (0.7); 7.2597 (66.6); 4.5411 (0.8); 4.5259 (0.8); 2.8763 (0.5); 1.5380 (16.0); 0.0079 (0.7); -0.0002 (23.2); -0.0085 (0.6) I.2-82:1H NMR (400.0MHz, d6-DMSO): δ= 8.6770 (2.8); 7.9630 (5.1); 7.7535 (2.8); 7.7358 (3.2); 7.5463 (2.8); 7.5264 (4.9); 7.5079 (7.4); 7.4879 (7.1); 7.4860 (7.4); 7.4014 (16.0); 7.3812 (4.5); 7.3747 (2.6); 7.3465 (3.6); 7.3274 (2.9); 7.1767 (3.4); 7.0370 (7.1); 6.8975 (3.5); 4.3778 (9.0); 4.3633 (8.8); 4.1085 (2.8); 4.0843 (4.6); 4.0630 (3.9); 3.9656 (3.7); 3.9510 (3.9); 3.9413 (2.8); 3.9268 (2.9); 3.4127 (0.9); 3.3904 (1.4); 3.3748 (2.2); 3.3602 (2.3); 3.3106 (277.9); 2.8517 (2.9); 2.8286 (2.8); 2.8094 (5.0); 2.7861 (4.6); 2.7215 (5.1); 2.7044 (4.7); 2.6790 (3.2); 2.6698 (2.0); 2.6619 (3.2); 2.5231 (6.0); 2.5184 (7.9); 2.5097 (117.9); 2.5052 (257.5); 2.5006 (358.3); 2.4959 (249.4); 2.4914 (110.0); 2.3273 (2.2); 1.2356 (1.9); -0.0002 (24.8) I.2-83:1H NMR (400.0MHz, CDCl3): δ= 8.7245 (8.8); 7.9774 (9.5); 7.9738 (9.6); 7.5796 (10.4); 7.5741 (4.2); 7.5677 (11.1); 7.5623 (6.9); 7.5566 (12.3); 7.5506 (4.6); 7.5447 (11.7); 7.5185 (4.5); 7.3104 (3.1); 7.2979 (3.5); 7.2597 (772.4); 7.1640 (3.8); 7.0913 (12.3); 7.0855 (4.3); 7.0706 (14.4); 7.0683 (13.4); 7.0533 (4.0); 7.0477 (11.4); 6.9956 (4.2); 4.7737 (12.1); 4.7625 (12.4); 4.2270 (6.0); 4.2086 (6.6); 4.2028 (7.7); 4.1845 (8.0); 4.0259 (7.5); 4.0044 (9.0); 4.0019 (7.6); 3.9804 (6.5); 3.4163 (1.5); 3.3949 (3.9); 3.3741 (4.4); 3.3533 (3.8); 3.3313 (1.6); 3.0471 (5.1); 3.0256 (4.7); 3.0046 (9.5); 2.9832 (8.7); 2.9231 (9.8); 2.8994 (9.2); 2.8806 (4.9); 2.8569 (4.3); 1.5508 (16.0); 1.4172 (1.4); 0.0080 (10.0); -0.0002 (272.0); -0.0084 (12.2) I.2-84:1H NMR (400.0MHz, d6-DMSO): δ= 8.6670 (6.0); 7.6848 (8.8); 7.6726 (9.9); 7.6624 (10.6); 7.6498 (9.4); 7.6200 (11.7); 7.6154 (11.5); 7.4427 (4.5); 7.4222 (9.3); 7.4176 (8.8); 7.3871 (12.7); 7.3663 (5.9); 7.2337 (9.2); 7.2116 (15.8); 7.1898 (7.8); 4.3586 (16.0); 4.3447 (15.5); 4.0406 (3.8); 4.0178 (7.9); 3.9949 (5.6); 3.9102 (5.4); 3.8949 (6.2); 3.8864 (4.4); 3.8705 (4.1); 3.3094 (372.2); 2.7966 (3.2); 2.7728 (3.2); 2.7541 (7.0); 2.7310 (6.4); 2.6919 (7.6); 2.6739 (9.8); 2.6490 (3.6); 2.6317 (3.4); 2.5004 (645.8); 2.3280 (3.9); -0.0002 (41.5) I.2-85:1H NMR (400.0MHz, d6-DMSO): δ= 8.6954 (4.1); 7.7513 (1.1); 7.6844 (6.0); 7.6615 (7.5); 7.6486 (6.2); 7.5072 (4.5); 7.4853 (6.2); 7.4563 (1.8); 7.3986 (16.0); 7.3806 (4.8); 7.3420 (3.1); 7.2340 (6.0); 7.2125 (9.9); 7.1903 (5.3); 4.3726 (10.6); 4.3586 (10.4); 4.2850 (2.0); 4.2690 (2.1); 4.0558 (2.5); 4.0310 (5.4); 4.0100 (3.6); 3.9167 (3.8); 3.9028 (4.2); 3.8791 (2.6); 3.3101 (294.1); 2.8094 (2.6); 2.7866 (2.8); 2.7667 (4.4); 2.7448 (4.5); 2.6857 (5.9); 2.6689 (9.1); 2.6434 (4.6); 2.6249 (5.1); 2.5005 (680.7); 2.3274 (4.4); 0.8529 (1.8); -0.0002 (43.1) I.2-86:1H NMR (400.0 MHz, CDCl3): δ= 7.3537 (2.7); 7.3526 (2.7); 7.3332 (4.7); 7.2937 (0.7); 7.2893 (0.8); 7.2749 (0.9); 7.2730 (0.9); 7.2705 (1.3); 7.2688 (1.4); 7.2604 (35.0); 7.2560 (1.8); 7.2502 (1.3); 7.2406 (1.6); 7.2365 (1.1); 7.2274 (1.9); 7.2088 (1.5); 7.2058 (1.4); 7.1872 (1.1); 6.9960 (1.0); 6.9928 (1.0); 6.9769 (1.3); 6.9738 (1.4); 6.9578 (0.7); 6.9546 (0.8); 6.9465 (1.3); 6.9437 (1.1); 6.9259 (1.2); 6.9232 (1.0); 4.8186 (2.7); 4.8050 (2.6); 4.0121 (1.0); 3.9948 (1.0); 3.9876 (1.4); 3.9703 (1.5); 3.8806 (1.4); 3.8594 (1.6); 3.8561 (1.2); 3.8349 (1.1); 3.7666 (16.0); 3.2246 (0.7); 3.2216 (0.6); 3.2043 (0.5); 2.9299 (1.0); 2.9099 (0.9); 2.8876 (1.6); 2.8677 (1.4); 2.7694 (1.6); 2.7458 (1.5); 2.7271 (1.0); 2.7035 (0.9); 1.5731 (0.5); -0.0002 (12.1) I.2-87:1H NMR (400.0 MHz, CDCl3): δ= 7.5190 (1.1); 7.4036 (2.4); 7.3887 (2.7); 7.3806 (4.6); 7.3657 (5.2); 7.3598 (17.0); 7.3440 (5.0); 7.3394 (23.8); 7.3073 (0.8); 7.2885 (0.7); 7.2844 (0.6); 7.2602 (191.0); 7.2365 (10.7); 7.2179 (8.7); 7.2148 (7.8); 7.1962 (5.8); 6.9962 (1.1); 6.9323 (2.0); 6.9295 (1.4); 6.9253 (2.9); 6.9225 (3.5); 6.9168 (3.8); 6.9106 (5.5); 6.9052 (6.1); 6.9033 (6.0); 6.8956 (4.0); 6.8899 (7.9); 6.8852 (5.2); 6.8839 (5.5); 6.8785 (1.5); 6.8687 (3.8); 6.8622 (2.5); 5.8333 (2.6); 4.8222 (16.0); 4.8086 (15.5); 4.7866 (0.7); 4.7722 (0.5); 4.0547 (3.5); 4.0353 (4.1); 4.0308 (5.3); 4.0126 (5.3); 3.9183 (5.5); 3.8965 (7.2); 3.8730 (4.3); 3.2587 (1.2); 3.2376 (3.2); 3.2191 (3.4); 3.2166 (4.1); 3.2141 (3.7); 3.1958 (3.4); 3.1747 (1.5); 2.9435 (5.4); 2.9226 (4.6); 2.9009 (8.3); 2.8800 (7.6); 2.7736 (8.0); 2.7499 (7.5); 2.7310 (5.2); 2.7073 (4.6); 2.0419 (0.7); 1.5554 (2.4); 1.2579 (0.9); 0.0080 (2.4); -0.0002 (71.8); -0.0085 (3.0) I.2-88:1H NMR (400.0MHz, CDCl3): δ= 7.7456 (0.9); 7.3973 (0.6); 7.3914 (0.5); 7.2854 (0.9); 7.2782 (0.6); 7.2743 (0.8); 7.2719 (0.8); 7.2680 (0.9); 7.2594 (69.6); 6.6341 (0.7); 4.5960 (1.4); 4.5812 (1.4); 3.9768 (0.6); 2.9520 (0.6); 2.9302 (0.6); 2.8574 (0.6); 2.8336 (0.5); 1.5343 (16.0); 0.0080 (0.8); -0.0002 (24.9); -0.0085 (0.7) I.2-89:1H NMR (400.0MHz, CDCl3): δ= 8.7265 (5.0); 8.7240 (4.9); 7.9801 (5.3); 7.9788 (5.5); 7.9752 (5.4); 7.9740 (5.0); 7.5877 (1.4); 7.5800 (13.4); 7.5745 (4.2); 7.5629 (4.7); 7.5573 (16.0); 7.5496 (1.7); 7.5205 (0.6); 7.3551 (2.0); 7.3475 (17.1); 7.3419 (4.7); 7.3303 (4.4); 7.3248 (13.5); 7.3171 (1.3); 7.2729 (0.8); 7.2713 (1.0); 7.2697 (1.2); 7.2689 (1.3); 7.2681 (1.5); 7.2616 (102.2); 7.2113 (1.0); 7.1808 (1.8); 6.9976 (0.6); 4.7709 (7.1); 4.7599 (6.9); 4.2214 (4.0); 4.2029 (4.2); 4.1973 (4.9); 4.1788 (5.1); 4.0277 (4.7); 4.0062 (5.8); 4.0036 (4.5); 3.9821 (4.0); 3.4170 (0.8); 3.3953 (2.2); 3.3767 (2.3); 3.3744 (2.5); 3.3720 (2.4); 3.3534 (2.3); 3.3504 (1.4); 3.3318 (0.9); 3.0540 (3.6); 3.0323 (3.0); 3.0113 (6.3); 2.9897 (5.9); 2.9253 (6.4); 2.9017 (5.9); 2.8827 (3.4); 2.8590 (3.1); 2.0448 (0.8); 1.5796 (5.8); 1.2591 (0.6); 0.0080 (1.4); -0.0002 (43.8); -0.0085 (1.3) I.2-90:1H NMR (400.0 MHz, CDCl3): δ= 8.7297 (8.1); 8.7276 (9.7); 8.7250 (9.5); 7.9699 (10.6); 7.9685 (10.9); 7.9650 (10.5); 7.9636 (10.0); 7.5226 (1.0); 7.2781 (0.5); 7.2765 (0.6); 7.2757 (0.6); 7.2749 (0.7); 7.2741 (0.7); 7.2733 (0.9); 7.2725 (1.0); 7.2709 (1.6); 7.2701 (1.9); 7.2693 (2.1); 7.2685 (2.7); 7.2677 (3.2); 7.2637 (189.6); 7.2604 (3.8); 7.2595 (2.4); 7.2587 (1.5); 7.2579 (1.0); 7.2571 (0.7); 7.2562 (0.6); 7.2554 (0.6); 7.2547 (0.5); 7.2138 (1.4); 7.1117 (3.2); 6.9996 (1.1); 4.7481 (13.4); 4.7371 (13.2); 4.7042 (1.1); 4.6833 (3.1); 4.6604 (5.3); 4.6405 (2.9); 4.6167 (1.2); 3.7788 (4.2); 3.7605 (5.0); 3.7546 (10.0); 3.7363 (10.5); 3.7223 (10.3); 3.7009 (11.7); 3.6983 (6.0); 3.6766 (5.0); 3.2646 (1.8); 3.2461 (2.3); 3.2434 (4.2); 3.2407 (2.8); 3.2250 (4.0); 3.2222 (5.2); 3.2193 (4.8); 3.2010 (4.3); 3.1982 (2.8); 3.1797 (1.9); 2.8260 (5.9); 2.8049 (5.3); 2.7840 (12.2); 2.7629 (11.5); 2.7188 (13.0); 2.6947 (12.2); 2.6768 (6.2); 2.6527 (5.6); 2.2580 (0.6); 2.2341 (1.9); 2.2293 (2.6); 2.2082 (3.6); 2.2050 (6.2); 2.2021 (4.1); 2.1807 (7.4); 2.1734 (5.0); 2.1600 (6.6); 2.1562 (7.4); 2.1537 (9.2); 2.1462 (6.2); 2.1428 (5.2); 2.1396 (6.5); 2.1306 (5.7); 2.1264 (6.0); 2.1180 (2.6); 2.1140 (2.1); 2.1060 (1.2); 2.1016 (0.9); 1.7417 (2.0); 1.7359 (1.4); 1.7338 (1.4); 1.7246 (6.4); 1.7170 (3.9); 1.7124 (5.5); 1.7008 (10.1); 1.6922 (2.6); 1.6876 (6.0); 1.6769 (4.8); 1.6645 (1.4); 1.6621 (1.7); 1.6033 (16.0); 1.2560 (0.7); 0.0080 (2.4); 0.0065 (0.8); 0.0057 (0.9); 0.0049 (1.0); 0.0041 (1.2); 0.0024 (3.0); -0.0002 (81.4); -0.0058 (0.6); -0.0085 (2.1); -0.0500 (0.6) I.2-91:1H NMR (400.0MHz, CDCl3): δ= 8.5555 (4.9); 8.5435 (4.9); 7.8965 (4.0); 7.8761 (4.5); 7.8442 (8.2); 7.7242 (3.2); 7.7198 (3.1); 7.7050 (6.3); 7.7007 (6.0); 7.6858 (3.8); 7.6814 (3.5); 7.5194 (0.9); 7.5081 (2.9); 7.4886 (6.4); 7.4682 (4.1); 7.4173 (5.9); 7.3978 (3.6); 7.2836 (7.0); 7.2606 (132.3); 7.2493 (5.0); 7.2428 (4.1); 7.2303 (3.3); 7.1492 (2.7); 6.9966 (0.7); 4.6194 (16.0); 4.6079 (15.6); 4.2470 (4.8); 4.2283 (5.7); 4.2230 (6.3); 4.2044 (6.2); 4.0562 (5.8); 4.0345 (8.0); 4.0107 (4.8); 3.3810 (1.1); 3.3592 (3.2); 3.3382 (4.0); 3.3174 (3.4); 3.2957 (1.3); 3.0652 (4.5); 3.0435 (3.8); 3.0224 (7.5); 3.0007 (6.8); 2.9155 (7.4); 2.8919 (6.8); 2.8726 (4.3); 2.8490 (3.9); 1.6454 (2.8); 1.2522 (1.6); -0.0002 (47.6); -0.0084 (2.0) I.2-92:1H NMR (400.0MHz, d6-DMSO): δ= 8.7249 (3.9); 8.7101 (6.5); 8.6975 (3.3); 8.1750 (12.6); 7.8313 (6.1); 7.8111 (7.0); 7.6398 (4.9); 7.6200 (9.7); 7.5998 (5.2); 7.4993 (8.4); 7.4799 (6.2); 7.3741 (2.0); 7.3675 (2.4); 7.3496 (4.7); 7.3354 (5.1); 7.3294 (3.9); 7.3226 (4.0); 7.3096 (2.1); 7.2177 (2.3); 7.1982 (6.2); 7.1860 (11.2); 7.1778 (10.1); 7.1713 (11.0); 4.3960 (16.0); 4.3817 (15.5); 4.1073 (5.6); 4.0831 (9.5); 4.0616 (8.1); 3.9666 (7.8); 3.9516 (8.4); 3.9421 (5.7); 3.9274 (6.0); 3.3645 (7.3); 3.3140 (679.5); 3.2647 (3.5); 2.8397 (5.5); 2.8165 (5.5); 2.7973 (10.3); 2.7741 (9.5); 2.7161 (10.3); 2.6985 (9.7); 2.6738 (11.4); 2.6698 (9.6); 2.6653 (6.9); 2.6561 (7.0); 2.5518 (9.6); 2.5470 (7.9); 2.5229 (55.5); 2.5096 (562.0); 2.5052 (1074.2); 2.5006 (1387.8); 2.4961 (970.0); 2.4917 (441.8); 2.4608 (8.4); 2.4003 (1.5); 2.3566 (1.9); 2.3320 (6.2); 2.3274 (8.1); 2.3230 (5.6); 2.0726 (1.2); -0.0002 (33.3) I.2-93:1H NMR (400.0 MHz, CDCl3): δ= 7.3630 (1.8); 7.3568 (1.9); 7.3193 (1.9); 7.3082 (0.7); 7.3039 (0.9); 7.2980 (3.1); 7.2894 (0.9); 7.2875 (0.9); 7.2850 (1.1); 7.2833 (1.1); 7.2686 (2.2); 7.2644 (2.8); 7.2604 (29.4); 7.2490 (1.7); 7.2448 (1.2); 7.2352 (1.6); 7.2289 (1.4); 7.2139 (1.0); 7.2077 (0.9); 7.0094 (0.9); 7.0063 (1.0); 6.9904 (1.4); 6.9873 (1.5); 6.9713 (0.7); 6.9681 (0.8); 6.9615 (1.4); 6.9587 (1.2); 6.9408 (1.2); 6.9380 (1.0); 4.5356 (3.2); 4.5205 (3.1); 4.0157 (0.9); 3.9995 (1.0); 3.9910 (1.4); 3.9748 (1.5); 3.9067 (1.4); 3.8860 (1.6); 3.8820 (1.1); 3.8613 (1.0); 3.7866 (16.0); 3.2663 (0.7); 2.9037 (0.7); 2.8850 (0.6); 2.8614 (1.8); 2.8427 (1.6); 2.8139 (1.7); 2.7904 (1.6); 2.7716 (0.7); 2.7480 (0.6); -0.0002 (10.5) I.2-94:1H NMR (400.0 MHz, CDCl3): δ= 8.7615 (0.5); 8.7241 (11.8); 7.9738 (12.4); 7.9697 (12.6); 7.9421 (0.7); 7.8895 (0.5); 7.5192 (2.2); 7.4402 (3.3); 7.4316 (1.2); 7.4252 (4.5); 7.4170 (6.6); 7.4024 (6.4); 7.3961 (4.6); 7.3813 (4.5); 7.3113 (0.6); 7.2892 (0.8); 7.2604 (401.7); 7.2101 (0.7); 7.1587 (4.1); 6.9963 (2.1); 6.9491 (2.8); 6.9395 (6.5); 6.9371 (6.2); 6.9311 (5.2); 6.9271 (3.7); 6.9221 (8.8); 6.9202 (9.6); 6.9159 (7.0); 6.9103 (10.2); 6.9026 (6.8); 6.8956 (1.8); 6.8894 (5.7); 6.8827 (3.4); 5.2985 (0.7); 4.7703 (16.0); 4.7596 (15.7); 4.3860 (0.7); 4.2517 (1.3); 4.1133 (4.9); 4.0941 (5.6); 4.0893 (7.8); 4.0713 (8.0); 4.0138 (8.7); 3.9923 (10.5); 3.9686 (6.0); 3.6197 (0.6); 3.4830 (1.8); 3.4622 (4.7); 3.4414 (5.8); 3.4206 (4.8); 3.3997 (1.9); 3.0187 (7.3); 2.9979 (6.6); 2.9761 (12.9); 2.9553 (12.2); 2.8787 (12.8); 2.8552 (12.2); 2.8361 (7.3); 2.8126 (6.5); 2.1351 (1.0); 1.7417 (0.7); 1.4796 (0.8); 1.2449 (0.7); 0.0695 (0.5); 0.0080 (4.4); -0.0002 (146.2); -0.0085 (4.2); -0.1498 (0.6) I.2-95:1H NMR (400.0MHz, CDCl3): δ= 8.7259 (10.0); 7.9786 (10.9); 7.9751 (10.9); 7.7773 (14.9); 7.7748 (16.0); 7.7606 (6.6); 7.7579 (7.2); 7.7551 (5.6); 7.5190 (2.8); 7.4910 (3.5); 7.4714 (6.6); 7.4494 (4.4); 7.3264 (7.1); 7.3071 (5.9); 7.2602 (482.4); 7.1850 (4.5); 6.9961 (2.8); 6.7866 (6.1); 6.6456 (12.5); 6.5047 (6.2); 4.7768 (13.4); 4.7660 (13.6); 4.2703 (6.8); 4.2519 (7.7); 4.2461 (9.6); 4.2278 (9.0); 4.0887 (8.4); 4.0672 (10.4); 4.0646 (8.2); 4.0431 (7.0); 3.4327 (1.5); 3.4110 (4.1); 3.3901 (4.8); 3.3877 (4.7); 3.3694 (4.3); 3.3479 (1.9); 3.0935 (0.8); 3.0796 (6.4); 3.0582 (5.6); 3.0369 (11.0); 3.0155 (10.2); 2.9469 (11.0); 2.9234 (10.2); 2.9042 (6.0); 2.8806 (5.5); 1.6381 (2.8); 1.3637 (1.3); 0.0696 (1.0); 0.0080 (5.4); -0.0002 (171.9); -0.0085 (6.7); -0.1496 (0.7) I.2-96:1H NMR (400.0MHz, d6-DMSO): δ= 8.7150 (0.8); 8.7001 (1.6); 8.6854 (0.7); 8.3351 (2.9); 8.3303 (2.9); 8.3288 (2.7); 7.7657 (2.1); 7.7593 (2.1); 7.7451 (2.5); 7.7388 (2.4); 7.5289 (5.8); 7.5241 (1.9); 7.5124 (2.1); 7.5075 (6.7); 7.4993 (4.1); 7.4977 (3.9); 7.4787 (3.4); 7.4772 (3.3); 7.1799 (4.7); 7.1594 (4.2); 4.3366 (4.8); 4.3220 (4.7); 4.0046 (1.5); 3.9827 (2.3); 3.9802 (2.7); 3.9586 (2.1); 3.8763 (2.3); 3.8608 (2.4); 3.8519 (1.6); 3.8365 (1.7); 3.3701 (0.8); 3.3204 (93.2); 3.2801 (1.3); 3.2703 (1.1); 3.2635 (1.0); 2.7609 (1.3); 2.7377 (1.2); 2.7187 (3.1); 2.6954 (2.8); 2.6709 (3.7); 2.6653 (0.9); 2.6525 (2.8); 2.6288 (1.1); 2.6103 (1.2); 2.5552 (0.9); 2.5506 (1.2); 2.5456 (1.2); 2.5234 (3.9); 2.5188 (5.3); 2.5101 (56.0); 2.5055 (120.0); 2.5009 (166.7); 2.4962 (116.4); 2.4916 (51.5); 2.4552 (1.0); 2.4507 (1.5); 2.4459 (1.2); 2.4416 (0.7); 2.3323 (0.8); 2.3277 (1.1); 2.3230 (0.9); 2.2748 (16.0); 2.0734 (0.7); 0.1265 (1.3); 0.0081 (1.0); -0.0002 (34.2); -0.0086 (1.0) I.2-97:1H NMR (400.0 MHz, CDCl3): δ= 8.7241 (7.8); 8.7215 (7.7); 7.9759 (8.5); 7.9745 (8.7); 7.9710 (8.6); 7.9697 (8.1); 7.6151 (1.9); 7.6134 (2.3); 7.6108 (11.9); 7.6079 (14.1); 7.6027 (3.7); 7.5937 (4.5); 7.5913 (8.1); 7.5888 (16.0); 7.5861 (13.9); 7.5804 (1.6); 7.5202 (0.9); 7.4045 (1.9); 7.3995 (11.2); 7.3978 (4.8); 7.3943 (3.7); 7.3863 (2.4); 7.3809 (14.2); 7.3783 (10.3); 7.3729 (1.7); 7.3641 (4.1); 7.3614 (4.4); 7.3594 (11.3); 7.3539 (1.4); 7.2733 (0.5); 7.2725 (0.6); 7.2717 (0.7); 7.2709 (0.8); 7.2701 (0.9); 7.2693 (1.0); 7.2685 (1.3); 7.2677 (1.6); 7.2669 (1.8); 7.2613 (162.9); 7.2571 (1.8); 7.2563 (1.2); 7.2555 (0.9); 7.2547 (0.6); 7.2538 (0.6); 7.2531 (0.6); 7.2112 (1.3); 7.1923 (5.4); 7.1895 (8.8); 7.1867 (6.1); 7.1745 (5.0); 7.1728 (5.2); 7.1710 (10.2); 7.1692 (4.8); 7.1673 (3.6); 7.1552 (2.7); 7.1524 (4.5); 7.1496 (2.3); 6.9972 (0.9); 4.7735 (11.1); 4.7625 (11.0); 4.2503 (6.7); 4.2315 (7.2); 4.2260 (8.5); 4.2073 (8.8); 4.0596 (8.2); 4.0381 (9.7); 4.0353 (7.6); 4.0139 (6.9); 3.4200 (1.4); 3.4011 (1.9); 3.3982 (3.6); 3.3793 (3.7); 3.3773 (4.0); 3.3750 (4.1); 3.3561 (3.8); 3.3533 (2.3); 3.3344 (1.6); 3.0629 (6.2); 3.0410 (5.3); 3.0204 (10.5); 2.9986 (9.8); 2.9248 (10.5); 2.9012 (9.9); 2.8823 (6.0); 2.8588 (5.4); 1.5844 (8.5); 0.0080 (2.0); 0.0056 (0.6); 0.0048 (0.8); -0.0002 (68.9); - 0.0085 (1.8) I.2-98:1H NMR (400.0MHz, CDCl3): δ= 8.7224 (1.4); 8.7200 (1.4); 7.9635 (1.5); 7.9596 (1.5); 7.3080 (2.2); 7.3035 (1.3); 7.2907 (1.9); 7.2882 (2.6); 7.2842 (1.5); 7.2728 (1.3); 7.2684 (0.9); 7.2604 (36.2); 7.2001 (0.5); 7.0163 (0.8); 7.0132 (1.0); 6.9969 (1.2); 6.9942 (1.8); 6.9755 (1.9); 6.9544 (1.2); 6.9511 (0.9); 4.7744 (2.0); 4.7631 (1.9); 4.0791 (0.9); 4.0612 (1.0); 4.0548 (1.5); 4.0368 (1.5); 3.9874 (1.5); 3.9662 (1.7); 3.9630 (1.1); 3.9419 (1.0); 3.8345 (16.0); 3.4461 (0.6); 3.4280 (0.6); 3.4254 (0.7); 3.4227 (0.6); 3.4047 (0.6); 3.0108 (1.0); 2.9903 (0.9); 2.9687 (1.6); 2.9481 (1.5); 2.8635 (1.6); 2.8400 (1.6); 2.8213 (1.0); 2.7978 (0.9); 1.5634 (6.0); - 0.0002 (13.4) I.2-99:1H NMR (400.0MHz, CDCl3): δ= 8.3042 (3.7); 8.2988 (3.7); 7.6318 (2.8); 7.6254 (2.8); 7.6113 (3.1); 7.6050 (3.1); 7.5214 (0.6); 7.3220 (4.7); 7.3015 (4.3); 7.2625 (107.4); 7.2126 (0.8); 6.9985 (0.6); 6.0973 (1.0); 4.5131 (1.2); 4.4985 (1.1); 4.4903 (1.9); 4.4757 (3.7); 4.4699 (3.0); 4.4607 (3.6); 4.4479 (4.4); 4.4326 (3.5); 4.4099 (1.0); 4.3950 (1.0); 3.6439 (2.1); 3.6262 (2.3); 3.6196 (3.2); 3.6019 (3.2); 3.5262 (3.1); 3.5047 (3.8); 3.5021 (2.8); 3.4804 (2.4); 3.0792 (0.7); 3.0613 (0.9); 3.0581 (1.5); 3.0554 (1.1); 3.0404 (1.5); 3.0373 (2.0); 3.0342 (1.8); 3.0164 (1.6); 3.0132 (1.1); 2.9953 (0.7); 2.7072 (1.5); 2.6865 (1.4); 2.6657 (4.7); 2.6449 (4.4); 2.6322 (4.8); 2.6082 (4.3); 2.5906 (1.6); 2.5666 (1.4); 1.8484 (1.5); 1.8371 (1.6); 1.8189 (1.8); 1.7982 (1.0); 1.6958 (1.9); 1.6887 (2.0); 1.6812 (1.6); 1.6720 (1.9); 1.6492 (1.0); 1.6403 (1.3); 1.6283 (1.0); 1.6216 (1.8); 1.6173 (2.0); 1.6087 (2.0); 1.6013 (2.6); 1.5885 (16.0); 1.5727 (1.8); 1.5580 (1.3); 1.5487 (1.2); 1.5369 (1.0); 1.5279 (1.1); 1.5193 (1.0); 1.5071 (1.0); 1.4987 (1.1); 1.4887 (1.0); 1.4850 (0.9); 1.4782 (1.0); 1.4680 (0.9); 1.4491 (0.7); 0.0080 (1.2); -0.0002 (43.3); -0.0085 (1.5) I.2-100:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.6849 (3.4); 7.6210 (13.3); 7.6160 (11.7); 7.5991 (6.6); 7.5932 (5.7); 7.5798 (4.3); 7.5408 (2.6); 7.4723 (4.5); 7.4496 (8.1); 7.4433 (5.6); 7.4381 (9.7); 7.4224 (9.9); 7.4182 (16.0); 7.3982 (3.9); 7.3920 (9.5); 7.3713 (4.2); 7.2331 (12.6); 7.0480 (6.3); 6.9663 (3.0); 6.9440 (3.3); 4.3593 (8.6); 4.3446 (8.1); 4.0656 (3.6); 4.0407 (5.4); 4.0196 (4.0); 3.9270 (3.6); 3.9125 (4.1); 3.9029 (3.0); 3.8874 (2.9); 3.8636 (8.2); 3.3802 (15.6); 2.8313 (2.4); 2.8082 (2.6); 2.7890 (5.4); 2.7656 (4.7); 2.7136 (4.9); 2.6962 (4.8); 2.6701 (4.8); 2.6537 (2.3); 2.5232 (8.4); 2.5184 (12.7); 2.5097 (204.1); 2.5051 (454.2); 2.5005 (639.7); 2.4959 (456.1); 2.4913 (207.7); 2.3271 (3.4); 1.4615 (3.0); 0.9137 (3.3); -0.0002 (70.9) I.2-101:1H NMR (400.0MHz, CDCl3): δ= 7.5223 (0.5); 7.4041 (0.8); 7.3936 (4.2); 7.3894 (3.7); 7.3885 (3.6); 7.3860 (4.6); 7.3840 (2.7); 7.3815 (6.1); 7.3787 (4.6); 7.3775 (4.8); 7.3745 (4.7); 7.3705 (6.2); 7.3660 (5.0); 7.3617 (1.2); 7.3565 (0.6); 7.3546 (0.7); 7.2755 (2.0); 7.2732 (1.8); 7.2715 (1.2); 7.2706 (1.4); 7.2698 (1.5); 7.2690 (1.7); 7.2682 (2.0); 7.2635 (96.3); 7.2609 (3.4); 7.2601 (2.4); 7.2591 (2.1); 7.2568 (6.9); 7.2549 (8.1); 7.2510 (6.6); 7.2487 (6.1); 7.2457 (0.9); 7.2412 (13.6); 7.2299 (0.8); 7.2135 (0.6); 6.0633 (1.5); 4.5529 (16.0); 4.5380 (15.5); 4.5085 (0.8); 4.4878 (2.9); 4.4675 (3.8); 4.4474 (2.3); 3.9589 (0.6); 3.6353 (3.4); 3.6174 (3.7); 3.6110 (4.8); 3.5931 (5.0); 3.5063 (5.0); 3.4848 (6.0); 3.4822 (4.3); 3.4605 (3.8); 3.0632 (1.1); 3.0452 (1.4); 3.0420 (2.4); 3.0392 (1.6); 3.0241 (2.3); 3.0210 (3.0); 3.0179 (2.7); 3.0027 (1.4); 3.0000 (2.5); 2.9968 (1.6); 2.9788 (1.2); 2.7195 (3.2); 2.6987 (2.8); 2.6779 (7.4); 2.6570 (6.8); 2.6233 (7.5); 2.5992 (6.9); 2.5817 (3.3); 2.5576 (2.9); 1.8575 (0.7); 1.8545 (0.8); 1.8385 (1.7); 1.8326 (2.3); 1.8293 (2.3); 1.8230 (2.0); 1.8180 (2.0); 1.8144 (2.2); 1.8092 (2.5); 1.8028 (1.9); 1.7994 (2.0); 1.7863 (1.3); 1.7835 (1.1); 1.7187 (0.6); 1.6992 (1.7); 1.6941 (1.9); 1.6829 (3.1); 1.6784 (3.6); 1.6707 (3.0); 1.6654 (2.7); 1.6608 (3.4); 1.6559 (2.6); 1.6468 (1.2); 1.6397 (1.8); 1.6283 (2.1); 1.6182 (1.4); 1.6098 (2.1); 1.6043 (2.7); 1.5954 (2.6); 1.5891 (2.9); 1.5852 (2.7); 1.5786 (2.3); 1.5755 (2.5); 1.5677 (3.1); 1.5624 (2.2); 1.5598 (2.1); 1.5511 (1.9); 1.5379 (1.6); 1.5286 (1.1); 1.5210 (1.5); 1.5151 (1.4); 1.5119 (1.3); 1.4999 (1.4); 1.4945 (1.5); 1.4813 (1.3); 1.4743 (1.4); 1.4629 (1.2); 1.4597 (1.1); 1.4441 (1.0); 0.0079 (1.0); 0.0021 (1.3); -0.0002 (38.2); -0.0028 (1.8); -0.0044 (0.7); -0.0053 (0.5); -0.0085 (1.2) I.2-102:1H NMR (400.0 MHz, CDCl3): δ= 8.5504 (4.5); 8.5480 (5.2); 8.5466 (5.2); 8.5442 (4.5); 8.5382 (4.6); 8.5359 (5.1); 7.7139 (3.7); 7.7095 (3.6); 7.6947 (7.0); 7.6903 (6.7); 7.6755 (4.3); 7.6711 (4.0); 7.4314 (2.3); 7.4223 (1.1); 7.4167 (3.2); 7.4083 (4.6); 7.3936 (4.5); 7.3876 (3.2); 7.3727 (2.9); 7.2742 (8.5); 7.2627 (74.1); 7.2546 (7.8); 7.2384 (4.0); 7.2371 (3.9); 7.2359 (3.8); 7.2320 (3.8); 7.2196 (3.4); 7.2184 (3.1); 7.1258 (2.8); 6.9380 (2.2); 6.9355 (1.5); 6.9309 (3.5); 6.9284 (4.6); 6.9255 (4.3); 6.9195 (4.5); 6.9160 (3.3); 6.9110 (6.5); 6.9090 (6.8); 6.9043 (5.3); 6.8986 (7.1); 6.8914 (5.3); 6.8844 (1.4); 6.8779 (3.6); 6.8712 (2.2); 4.6075 (16.0); 4.5958 (15.2); 4.0851 (3.4); 4.0653 (4.3); 4.0612 (5.5); 4.0427 (5.4); 3.9775 (5.9); 3.9555 (7.6); 3.9322 (4.1); 3.4254 (1.3); 3.4041 (3.4); 3.3832 (4.3); 3.3624 (3.4); 3.3411 (1.3); 2.9958 (5.1); 2.9746 (4.6); 2.9532 (8.1); 2.9321 (7.6); 2.8351 (8.0); 2.8116 (7.6); 2.7925 (4.9); 2.7690 (4.4); 1.7272 (0.7); 1.2562 (1.1); 0.0080 (1.6); -0.0002 (29.2); -0.0085 (0.9) I.2-103:1H NMR (400.0 MHz, CDCl3): δ= 8.7336 (15.9); 8.7213 (16.0); 7.5214 (0.8); 7.2706 (1.3); 7.2689 (1.7); 7.2626 (151.3); 7.2584 (2.6); 7.2568 (1.1); 7.2559 (0.8); 7.2551 (0.8); 7.2543 (0.6); 7.2535 (0.6); 7.2527 (0.6); 7.2495 (4.5); 7.2479 (6.3); 7.2373 (2.1); 7.2355 (3.1); 7.2127 (1.2); 6.9985 (0.9); 6.8999 (1.0); 4.7451 (3.6); 4.7415 (3.6); 4.7336 (3.8); 4.7300 (3.7); 4.7012 (0.7); 4.6815 (1.4); 4.6576 (2.3); 4.6377 (1.2); 4.6138 (0.5); 3.7889 (2.0); 3.7705 (2.4); 3.7647 (3.9); 3.7501 (1.1); 3.7462 (4.2); 3.7160 (4.1); 3.6943 (4.7); 3.6701 (2.4); 3.2455 (0.7); 3.2241 (1.7); 3.2056 (1.7); 3.2029 (2.0); 3.2001 (1.9); 3.1816 (1.8); 3.1600 (0.8); 2.8395 (2.5); 2.8182 (2.2); 2.7975 (4.6); 2.7762 (4.3); 2.7125 (5.1); 2.6884 (4.9); 2.6706 (2.8); 2.6464 (2.5); 2.2335 (0.9); 2.2286 (1.2); 2.2243 (0.6); 2.2087 (1.6); 2.2043 (2.5); 2.2002 (1.5); 2.1947 (0.7); 2.1845 (1.6); 2.1798 (2.7); 2.1762 (2.7); 2.1682 (1.8); 2.1592 (1.8); 2.1551 (3.4); 2.1525 (3.5); 2.1484 (2.9); 2.1430 (2.5); 2.1378 (2.2); 2.1338 (2.8); 2.1279 (2.8); 2.1213 (2.8); 2.1133 (1.1); 2.1082 (1.0); 2.1012 (0.5); 2.0944 (0.9); 1.7356 (0.9); 1.7304 (0.6); 1.7283 (0.6); 1.7189 (2.7); 1.7108 (1.8); 1.7058 (2.4); 1.6949 (4.3); 1.6818 (2.6); 1.6709 (2.1); 1.6588 (0.7); 1.6555 (0.9); 1.5992 (2.3); 0.0080 (1.9); -0.0002 (66.4); -0.0085 (1.8) I.2-104:1H NMR (400.0MHz, CDCl3): δ= 8.5582 (3.9); 8.5558 (4.6); 8.5541 (4.7); 8.5518 (4.1); 8.5459 (4.0); 8.5436 (4.6); 8.5419 (4.6); 8.5395 (3.7); 7.7685 (13.5); 7.7659 (14.2); 7.7494 (4.3); 7.7468 (5.0); 7.7440 (4.1); 7.7413 (2.8); 7.7223 (3.4); 7.7178 (3.4); 7.7031 (6.4); 7.6986 (6.3); 7.6839 (4.0); 7.6794 (3.8); 7.5193 (1.1); 7.4795 (3.0); 7.4774 (2.8); 7.4603 (5.6); 7.4582 (5.2); 7.4389 (3.0); 7.3164 (5.6); 7.3140 (4.5); 7.3100 (2.8); 7.2997 (4.1); 7.2972 (5.0); 7.2822 (8.2); 7.2750 (2.8); 7.2742 (2.7); 7.2734 (2.7); 7.2726 (2.8); 7.2717 (2.9); 7.2709 (3.1); 7.2701 (3.4); 7.2693 (3.7); 7.2603 (198.0); 7.2473 (4.0); 7.2460 (3.9); 7.2445 (3.8); 7.2427 (3.3); 7.2408 (3.8); 7.2284 (3.2); 7.2271 (3.1); 7.1351 (2.5); 6.9964 (1.1); 6.7791 (4.7); 6.6381 (9.5); 6.4972 (4.7); 4.6184 (16.0); 4.6068 (15.6); 4.2425 (5.5); 4.2237 (6.1); 4.2184 (7.0); 4.1997 (7.0); 4.0522 (6.6); 4.0306 (8.3); 4.0283 (6.9); 4.0066 (5.3); 3.3739 (1.3); 3.3521 (3.4); 3.3311 (4.0); 3.3291 (3.9); 3.3101 (3.5); 3.2883 (1.3); 3.0601 (5.3); 3.0382 (4.4); 3.0174 (8.5); 2.9955 (7.7); 2.9052 (8.4); 2.8816 (7.7); 2.8625 (5.0); 2.8389 (4.5); 1.6390 (3.5); 1.2552 (1.1); 0.0080 (2.7); -0.0002 (75.0); -0.0085 (2.5) I.2-105:1H NMR (400.0 MHz, CDCl3): δ= 8.5575 (4.7); 8.5470 (4.7); 7.7314 (3.3); 7.7269 (3.4); 7.7122 (6.4); 7.7078 (6.2); 7.6930 (3.9); 7.6885 (3.7); 7.5243 (5.7); 7.5186 (14.3); 7.5141 (5.5); 7.4434 (3.8); 7.4410 (4.4); 7.4382 (3.5); 7.4357 (3.4); 7.4227 (6.3); 7.4202 (6.5); 7.4174 (6.1); 7.4150 (5.0); 7.3671 (7.5); 7.3466 (11.6); 7.3261 (5.3); 7.3101 (1.8); 7.2874 (8.2); 7.2596 (1068.7); 7.2370 (3.6); 7.2305 (0.8); 7.2104 (2.1); 7.1285 (2.5); 6.9956 (5.9); 6.9306 (4.2); 6.9270 (3.9); 6.9103 (3.6); 6.9067 (3.6); 6.7088 (7.9); 6.5241 (15.9); 6.3395 (8.1); 4.6208 (16.0); 4.6092 (15.4); 4.2037 (5.2); 4.1849 (6.2); 4.1796 (7.1); 4.1608 (6.9); 4.0204 (6.6); 3.9987 (8.4); 3.9964 (6.6); 3.9747 (5.4); 3.3616 (1.2); 3.3399 (3.3); 3.3195 (3.9); 3.2976 (3.5); 3.2756 (1.2); 3.0509 (5.3); 3.0289 (4.3); 3.0082 (8.4); 2.9862 (7.8); 2.8973 (8.6); 2.8738 (7.8); 2.8546 (5.1); 2.8310 (4.5); 2.0051 (1.1); 1.5720 (14.7); 1.2560 (0.7); 0.1459 (1.2); 0.0079 (19.2); -0.0002 (403.6); -0.0085 (13.2); - 0.0315 (0.7); -0.0495 (0.9); -0.1497 (1.2) I.2-106:1H NMR (400.0 MHz, CDCl3): δ= 8.7300 (15.7); 8.7178 (16.0); 7.5210 (0.7); 7.2621 (139.5); 7.2571 (6.4); 7.2446 (7.0); 7.2323 (3.4); 7.2120 (1.5); 6.9981 (0.8); 6.8853 (1.5); 4.7402 (5.4); 4.7354 (5.7); 4.7288 (5.7); 4.7243 (5.5); 4.5502 (0.6); 4.5298 (2.0); 4.5096 (2.8); 4.4893 (1.6); 3.7088 (2.6); 3.6908 (3.0); 3.6845 (3.9); 3.6665 (4.0); 3.5820 (3.8); 3.5603 (4.8); 3.5361 (3.0); 3.2347 (0.8); 3.2134 (1.9); 3.1953 (1.9); 3.1924 (2.4); 3.1894 (2.2); 3.1714 (2.0); 3.1501 (0.8); 2.8302 (2.6); 2.8092 (2.3); 2.7884 (5.4); 2.7675 (5.0); 2.7181 (5.6); 2.6940 (5.2); 2.6763 (2.8); 2.6522 (2.5); 1.8743 (1.5); 1.8632 (2.4); 1.8544 (2.0); 1.8476 (2.3); 1.8434 (2.5); 1.8322 (1.7); 1.8229 (1.2); 1.8181 (1.3); 1.7368 (0.5); 1.7019 (2.5); 1.6979 (2.8); 1.6907 (2.3); 1.6822 (2.5); 1.6601 (1.3); 1.6467 (1.5); 1.6217 (2.4); 1.6132 (2.4); 1.6043 (3.4); 1.5878 (8.1); 1.5665 (1.9); 1.5569 (1.6); 1.5493 (1.4); 1.5353 (1.4); 1.5159 (1.2); 1.5040 (1.1); 1.4855 (0.9); 1.2539 (0.5); 0.0080 (1.8); -0.0002 (60.9); -0.0085 (2.4); -0.0503 (0.7) I.2-107:1H NMR (400.0MHz, CDCl3): δ= 8.7301 (9.9); 8.7178 (10.1); 7.2646 (48.3); 7.2603 (0.7); 7.2589 (1.2); 7.2572 (2.3); 7.2555 (1.2); 7.2467 (2.1); 7.2449 (4.1); 7.2432 (2.1); 7.2344 (1.0); 7.2326 (2.0); 7.2309 (1.0); 6.8970 (0.7); 4.7389 (3.8); 4.7272 (3.7); 3.7498 (1.8); 3.7322 (1.9); 3.7253 (2.3); 3.7077 (2.5); 3.5807 (2.5); 3.5589 (3.0); 3.5563 (2.2); 3.5344 (2.1); 3.2486 (0.6); 3.2452 (0.9); 3.2422 (0.7); 3.2276 (0.9); 3.2242 (1.3); 3.2209 (1.0); 3.2034 (0.9); 3.1998 (0.7); 3.1821 (0.5); 3.1725 (0.8); 3.1530 (0.8); 3.1388 (2.2); 3.1193 (2.3); 3.1046 (2.1); 3.0863 (2.1); 3.0708 (0.8); 3.0525 (0.8); 2.8474 (1.1); 2.8269 (1.0); 2.8055 (2.2); 2.7849 (2.0); 2.7299 (2.1); 2.7057 (1.9); 2.6879 (1.0); 2.6637 (1.0); 1.9644 (0.5); 1.9461 (0.9); 1.9291 (1.2); 1.9123 (1.0); 1.8935 (0.5); 1.6429 (0.5); 0.9224 (15.4); 0.9205 (16.0); 0.9058 (15.1); 0.9038 (15.6); 0.0080 (0.6); 0.0024 (0.6); 0.0016 (0.9); -0.0002 (22.6); -0.0085 (0.6) I.2-108:1H NMR (400.0MHz, CDCl3): δ= 8.3161 (3.8); 8.3147 (3.9); 8.3099 (3.9); 8.3084 (3.8); 7.6341 (3.0); 7.6278 (2.9); 7.6136 (3.4); 7.6073 (3.4); 7.5199 (1.6); 7.3289 (5.0); 7.3275 (5.0); 7.3084 (4.4); 7.3069 (4.5); 7.2770 (0.6); 7.2722 (0.9); 7.2714 (1.0); 7.2706 (1.1); 7.2698 (1.2); 7.2674 (2.4); 7.2610 (301.4); 7.2569 (3.3); 7.2560 (2.3); 7.2552 (1.6); 7.2544 (1.2); 7.2536 (1.2); 7.2528 (1.1); 7.2520 (0.8); 7.2512 (0.7); 7.2504 (0.6); 7.2496 (0.6); 7.2488 (0.5); 7.2108 (2.0); 6.9970 (1.6); 5.9814 (1.1); 4.6512 (1.5); 4.6277 (2.2); 4.6074 (1.3); 4.5245 (1.0); 4.5095 (1.0); 4.4868 (3.5); 4.4716 (3.4); 4.4561 (3.4); 4.4412 (3.4); 4.4185 (1.1); 4.4035 (1.0); 3.7254 (1.9); 3.7071 (2.2); 3.7012 (3.9); 3.6829 (4.0); 3.6586 (4.0); 3.6371 (4.6); 3.6129 (2.2); 3.0840 (0.7); 3.0627 (1.7); 3.0444 (1.6); 3.0415 (2.1); 3.0386 (2.0); 3.0203 (1.8); 2.9990 (0.8); 2.7263 (2.1); 2.7052 (1.9); 2.6846 (5.2); 2.6634 (4.7); 2.6372 (5.4); 2.6131 (4.9); 2.5954 (2.2); 2.5713 (1.9); 2.2022 (0.9); 2.1782 (1.6); 2.1751 (2.0); 2.1516 (2.9); 2.1450 (3.6); 2.1409 (2.7); 2.1322 (2.6); 2.1236 (4.6); 2.1182 (3.2); 2.1119 (1.9); 2.1016 (2.0); 2.0967 (1.4); 1.7346 (0.9); 1.7273 (0.7); 1.7170 (2.5); 1.7105 (1.9); 1.7045 (2.1); 1.6937 (3.9); 1.6865 (1.3); 1.6809 (2.0); 1.6711 (1.8); 1.6551 (0.7); 1.5602 (16.0); 0.0080 (3.1); -0.0002 (129.7); -0.0085 (3.8); -0.0503 (0.8) I.2-109:1H NMR (400.0MHz, CDCl3): δ= 8.5468 (2.0); 8.5362 (2.0); 7.7159 (1.4); 7.7115 (1.4); 7.6967 (2.7); 7.6923 (2.6); 7.6775 (1.7); 7.6731 (1.6); 7.5201 (0.7); 7.2723 (4.1); 7.2612 (131.9); 7.2532 (6.0); 7.2407 (2.4); 7.2344 (2.1); 7.2220 (1.6); 7.2116 (1.3); 7.0094 (1.0); 6.9972 (1.4); 4.5887 (6.8); 4.5770 (6.8); 3.7073 (1.9); 3.6895 (2.1); 3.6829 (2.7); 3.6652 (2.7); 3.5596 (2.6); 3.5378 (3.5); 3.5134 (2.2); 3.2235 (0.6); 3.2020 (1.2); 3.1813 (1.5); 3.1602 (2.0); 3.1395 (1.4); 3.1257 (2.8); 3.1061 (3.0); 3.0978 (2.8); 3.0794 (2.8); 3.0639 (0.9); 3.0455 (0.9); 2.8121 (1.3); 2.7916 (1.2); 2.7703 (2.7); 2.7496 (2.5); 2.6966 (2.6); 2.6724 (2.4); 2.6546 (1.3); 2.6306 (1.2); 1.9527 (0.6); 1.9352 (1.2); 1.9182 (1.5); 1.9012 (1.3); 1.8826 (0.6); 1.6314 (4.6); 0.9173 (16.0); 0.9133 (15.9); 0.9006 (16.0); 0.8966 (15.6); 0.0080 (1.9); -0.0002 (56.1); -0.0085 (2.5) I.2-110:1H NMR (400.0MHz, CDCl3): δ= 7.2678 (0.6); 7.2670 (0.6); 7.2661 (0.8); 7.2654 (1.0); 7.2645 (1.3); 7.2606 (73.7); 7.2572 (1.1); 7.2564 (0.7); 7.2556 (0.5); 7.2107 (0.5); 1.5458 (16.0); 0.9110 (2.0); 0.9083 (2.0); 0.8944 (2.0); 0.8916 (2.0); 0.0080 (0.9); -0.0002 (32.0); -0.0085 (0.9) I.2-111:1H NMR (400.0MHz, d6-DMSO): δ= 8.7254 (2.6); 8.7110 (4.2); 8.6958 (2.3); 8.3387 (8.7); 8.3340 (8.6); 8.3324 (8.3); 7.7694 (6.4); 7.7631 (6.2); 7.7489 (7.4); 7.7425 (7.5); 7.6543 (12.0); 7.6514 (14.6); 7.6463 (3.8); 7.6346 (7.8); 7.6322 (16.0); 7.6296 (13.6); 7.5008 (11.6); 7.4991 (11.4); 7.4802 (9.8); 7.4786 (9.8); 7.3892 (11.8); 7.3840 (3.4); 7.3707 (14.4); 7.3677 (11.1); 7.3538 (4.0); 7.3491 (11.8); 7.1560 (3.1); 7.1532 (6.3); 7.1505 (3.5); 7.1348 (9.5); 7.1163 (4.6); 5.7555 (2.4); 4.3406 (14.4); 4.3259 (14.4); 4.2282 (0.9); 4.0387 (5.2); 4.0172 (6.8); 4.0144 (8.2); 3.9929 (7.1); 3.9106 (7.2); 3.8952 (7.4); 3.8864 (5.1); 3.8709 (5.4); 3.8258 (0.9); 3.3684 (2.6); 3.3184 (1093.9); 3.2981 (4.9); 3.2918 (4.8); 3.2684 (9.8); 3.2564 (2.3); 3.2186 (1.4); 2.7862 (4.4); 2.7629 (4.0); 2.7439 (9.8); 2.7206 (8.9); 2.6909 (9.5); 2.6725 (11.0); 2.6653 (4.6); 2.6607 (2.2); 2.6486 (3.9); 2.6303 (3.6); 2.5553 (1.6); 2.5507 (2.4); 2.5460 (2.1); 2.5234 (13.8); 2.5187 (20.2); 2.5100 (314.0); 2.5054 (701.2); 2.5008 (993.8); 2.4962 (697.4); 2.4916 (311.3); 2.4601 (4.0); 2.4555 (6.5); 2.4510 (8.2); 2.4463 (6.6); 2.4003 (1.7); 2.3369 (2.3); 2.3323 (4.6); 2.3276 (6.2); 2.3230 (4.8); 2.0733 (3.1); 0.0080 (5.8); 0.0048 (1.6); 0.0039 (2.3); 0.0023 (7.1); -0.0002 (206.0); -0.0051 (4.0); -0.0085 (6.4); -0.0501 (1.4) I.2-112:1H NMR (400.0 MHz, CDCl3): δ= 8.5527 (3.8); 8.5503 (4.3); 8.5484 (4.4); 8.5460 (4.0); 8.5405 (4.0); 8.5380 (4.4); 8.5362 (4.4); 8.5337 (3.8); 7.7130 (4.1); 7.7085 (4.2); 7.6938 (7.2); 7.6893 (7.2); 7.6746 (5.0); 7.6701 (4.8); 7.5218 (1.3); 7.3128 (0.6); 7.2813 (0.6); 7.2789 (0.7); 7.2781 (0.8); 7.2749 (2.6); 7.2733 (4.7); 7.2709 (8.1); 7.2694 (7.1); 7.2685 (6.9); 7.2670 (5.8); 7.2662 (6.5); 7.2629 (224.8); 7.2596 (4.5); 7.2587 (2.8); 7.2579 (2.1); 7.2571 (2.0); 7.2562 (2.1); 7.2554 (2.8); 7.2538 (4.6); 7.2506 (8.6); 7.2490 (7.5); 7.2476 (5.4); 7.2436 (0.8); 7.2428 (0.7); 7.2420 (0.7); 7.2380 (4.1); 7.2365 (3.4); 7.2351 (3.5); 7.2332 (3.0); 7.2315 (3.7); 7.2301 (3.5); 7.2286 (3.4); 7.2191 (3.4); 7.2178 (3.0); 7.2164 (2.9); 7.2131 (2.2); 7.0325 (2.1); 6.9988 (1.5); 4.6903 (0.8); 4.6697 (2.4); 4.6469 (4.1); 4.6271 (2.3); 4.6032 (1.1); 4.5903 (16.0); 4.5786 (15.8); 3.7467 (3.0); 3.7279 (3.8); 3.7226 (8.0); 3.7038 (8.4); 3.6947 (8.4); 3.6731 (9.4); 3.6490 (3.7); 3.2058 (1.5); 3.1842 (3.4); 3.1653 (3.3); 3.1628 (4.1); 3.1603 (3.9); 3.1414 (3.5); 3.1388 (2.2); 3.1198 (1.5); 2.8058 (5.1); 2.7843 (4.4); 2.7639 (9.1); 2.7423 (8.5); 2.6764 (9.6); 2.6524 (9.2); 2.6345 (5.4); 2.6104 (4.8); 2.2205 (1.5); 2.2157 (2.1); 2.1951 (2.5); 2.1914 (4.8); 2.1881 (3.0); 2.1823 (1.0); 2.1669 (5.7); 2.1643 (4.8); 2.1594 (4.0); 2.1465 (4.8); 2.1428 (5.3); 2.1399 (7.4); 2.1347 (4.9); 2.1328 (5.0); 2.1295 (3.9); 2.1261 (5.0); 2.1169 (4.6); 2.1128 (4.5); 2.1046 (2.0); 2.1005 (1.6); 2.0925 (0.9); 2.0825 (0.5); 1.7288 (1.6); 1.7231 (1.2); 1.7210 (1.2); 1.7115 (5.1); 1.7040 (3.3); 1.6987 (4.6); 1.6878 (8.3); 1.6745 (6.3); 1.6624 (11.2); 1.2553 (0.7); 0.0081 (2.6); 0.0066 (0.6); 0.0057 (0.6); 0.0049 (0.7); 0.0041 (0.9); 0.0024 (2.7); -0.0002 (98.1); -0.0085 (2.8); -0.0501 (0.9) I.2-114:1H NMR (400.0MHz, CDCl3): δ= 8.1118 (7.1); 8.0987 (7.1); 7.5182 (3.7); 7.2812 (8.8); 7.2593 (663.2); 7.2388 (8.2); 7.2332 (6.7); 7.2143 (0.9); 7.2078 (0.5); 6.9954 (3.6); 6.8651 (4.9); 6.8617 (4.9); 6.8520 (4.7); 6.8485 (4.6); 6.7227 (8.5); 6.6448 (1.7); 6.6391 (2.7); 6.6337 (1.4); 6.6229 (3.2); 6.6172 (5.3); 6.6116 (2.8); 6.6009 (1.8); 6.5952 (2.7); 6.5895 (1.3); 6.0172 (2.0); 4.7945 (5.3); 4.7732 (15.7); 4.7517 (16.0); 4.7303 (5.4); 4.5379 (1.1); 4.5236 (1.2); 4.4989 (5.9); 4.4854 (8.8); 4.4716 (5.6); 4.4468 (0.9); 4.4312 (0.8); 4.3331 (7.5); 4.3088 (7.7); 3.5797 (8.6); 3.5554 (8.0); 3.1429 (7.0); 3.1011 (8.1); 2.5660 (9.3); 2.5243 (7.9); 2.0432 (1.7); 1.5597 (41.8); 1.5332 (141.7); 1.3830 (0.9); 1.3652 (0.8); 1.3326 (0.6); 1.2840 (0.9); 1.2584 (2.0); 1.2404 (0.6); 0.1459 (1.0); 0.0079 (11.3); -0.0002 (260.6); -0.0084 (9.5); -0.1495 (0.9) I.2-115:1H NMR (400.0MHz, CDCl3): δ= 8.4896 (2.3); 8.4769 (2.3); 7.2740 (1.7); 7.2683 (2.3); 7.2604 (37.2); 7.2506 (1.7); 7.2450 (1.4); 6.9965 (0.6); 6.9158 (1.7); 6.9031 (1.6); 6.6311 (0.5); 6.6149 (0.6); 6.6091 (1.1); 6.6034 (0.6); 6.5872 (0.5); 4.5301 (2.9); 4.5181 (2.9); 4.3199 (1.6); 4.2955 (1.6); 3.5827 (1.8); 3.5583 (1.7); 3.2043 (1.5); 3.1622 (1.7); 2.5869 (0.8); 2.5791 (16.0); 2.5363 (1.7); 2.0433 (1.6); 1.5856 (8.9); 1.2584 (1.0); 0.0078 (0.6); - 0.0002 (14.2); -0.0085 (0.5) I.2-118:1H NMR (400.0 MHz, CDCl3): δ= 8.1116 (3.6); 8.0984 (3.6); 7.5186 (0.8); 7.3120 (0.9); 7.2596 (147.8); 7.2389 (4.1); 7.2334 (3.3); 7.2220 (0.6); 6.9956 (0.8); 6.7489 (2.3); 6.7388 (2.2); 6.6414 (1.0); 6.6358 (1.6); 6.6301 (1.0); 6.6196 (1.8); 6.6138 (2.9); 6.6081 (1.8); 6.5983 (4.7); 6.5921 (1.8); 6.5863 (0.8); 6.0297 (1.0); 4.4910 (0.6); 4.4657 (3.3); 4.4601 (3.3); 4.4511 (3.2); 4.4455 (3.0); 4.3339 (3.7); 4.3095 (3.9); 4.2696 (4.9); 4.2528 (9.7); 4.2359 (4.8); 3.5731 (4.1); 3.5488 (3.9); 3.1496 (3.5); 3.1077 (3.9); 2.5571 (4.4); 2.5153 (3.8); 1.8367 (0.8); 1.8183 (2.4); 1.8011 (4.7); 1.7827 (4.7); 1.7655 (2.6); 1.7473 (0.8); 1.5503 (19.9); 1.2564 (0.6); 1.0376 (8.2); 1.0191 (16.0); 1.0005 (7.2); 0.0079 (2.8); -0.0002 (55.5); -0.0084 (2.3) I.2-119:1H NMR (400.0MHz, CDCl3): δ= 8.1648 (3.8); 8.1509 (3.9); 7.6467 (3.6); 7.5874 (15.6); 7.5829 (16.0); 7.5180 (4.8); 7.4644 (8.0); 7.2941 (1.2); 7.2822 (5.1); 7.2592 (882.8); 7.2262 (1.6); 7.2088 (2.0); 7.1671 (4.4); 7.1626 (7.9); 7.1581 (4.0); 6.9952 (5.0); 6.9907 (2.9); 6.9775 (2.6); 6.7587 (4.8); 6.7570 (4.8); 6.0514 (1.1); 4.5269 (2.8); 4.5119 (3.0); 4.5065 (3.0); 4.4913 (2.9); 4.4655 (0.8); 4.3364 (4.0); 4.3120 (4.1); 3.5856 (4.6); 3.5610 (4.3); 3.1272 (4.0); 3.0853 (4.6); 2.5661 (5.0); 2.5242 (4.3); 2.1356 (1.0); 2.1005 (1.0); 2.0431 (1.8); 1.5592 (21.7); 1.5308 (184.7); 1.2585 (2.0); 1.2406 (0.8); 0.1463 (1.1); 0.0080 (12.4); -0.0002 (339.5); - 0.0085 (10.8); -0.1493 (1.0) I.2-120:1H NMR (400.6 MHz, CDCl3): δ= 8.4663 (4.9); 8.4538 (5.0); 7.5946 (12.2); 7.5901 (13.0); 7.5853 (0.8); 7.5199 (1.0); 7.2867 (0.6); 7.2822 (0.9); 7.2743 (1.4); 7.2614 (172.4); 7.1549 (3.4); 7.1505 (6.1); 7.1460 (2.9); 6.9978 (1.0); 6.9561 (0.9); 6.8842 (3.6); 6.8717 (3.5); 4.5259 (5.7); 4.5146 (5.6); 4.4708 (2.4); 4.4531 (7.7); 4.4354 (7.8); 4.4178 (2.4); 4.3269 (3.0); 4.3026 (3.2); 4.1308 (1.0); 4.1130 (1.0); 3.5827 (3.4); 3.5584 (3.3); 3.1913 (2.9); 3.1492 (3.3); 2.5751 (3.8); 2.5332 (3.4); 2.1346 (0.6); 2.1016 (2.0); 2.0454 (4.8); 1.5761 (19.3); 1.5688 (8.9); 1.5365 (1.2); 1.4766 (7.8); 1.4590 (16.0); 1.4413 (7.5); 1.3326 (1.4); 1.2843 (2.0); 1.2774 (1.8); 1.2595 (4.7); 1.2555 (3.5); 1.2417 (1.7); 0.8800 (0.7); 0.0079 (1.6); -0.0002 (49.6); -0.0085 (1.6) I.2-122:1H NMR (400.0 MHz, CDCl3): δ= 8.1342 (1.2); 8.1328 (1.2); 8.1210 (1.2); 8.1196 (1.2); 7.2712 (0.6); 7.2601 (62.9); 7.2559 (1.9); 7.2542 (2.0); 7.2502 (0.7); 7.2405 (0.6); 7.2362 (1.4); 7.2305 (1.2); 6.7608 (0.8); 6.7571 (0.9); 6.7475 (0.8); 6.7439 (0.9); 6.6368 (0.5); 6.6206 (0.6); 6.6148 (1.1); 6.6091 (0.6); 6.5959 (1.3); 6.5939 (1.8); 6.5924 (1.8); 6.5904 (1.2); 5.2983 (2.2); 4.4685 (1.0); 4.4556 (1.3); 4.4426 (1.0); 4.3290 (1.3); 4.3046 (1.4); 3.9331 (16.0); 3.5700 (1.5); 3.5456 (1.4); 3.1425 (1.3); 3.1006 (1.4); 2.5533 (1.6); 2.5115 (1.4); 1.5476 (11.0); 1.2837 (0.6); 1.2558 (2.0); 0.0080 (0.7); -0.0002 (22.7); -0.0084 (0.7) I.2-123:1H NMR (400.0 MHz, CDCl3): δ= 8.1381 (1.7); 8.1249 (1.8); 7.5877 (7.6); 7.5833 (7.7); 7.5184 (3.1); 7.2595 (579.1); 7.2272 (0.6); 7.1626 (1.9); 7.1580 (3.6); 7.1535 (1.8); 6.9955 (3.2); 6.7624 (1.1); 6.7497 (1.1); 6.5993 (2.0); 4.4706 (1.2); 4.4606 (1.5); 4.4459 (1.2); 4.3371 (1.7); 4.3128 (2.0); 3.9399 (16.0); 3.5735 (2.1); 3.5491 (2.0); 3.1354 (1.7); 3.0934 (2.0); 2.5497 (2.2); 2.5079 (2.0); 2.0434 (1.6); 1.5436 (16.9); 1.5361 (33.2); 1.2842 (0.7); 1.2763 (0.8); 1.2584 (2.4); 1.2390 (0.9); 0.1459 (0.7); 0.0080 (6.5); -0.0002 (218.1); -0.0085 (6.1); -0.1495 (0.7) I.2-124:1H NMR (400.6 MHz, CDCl3): δ= 8.4657 (5.4); 8.4532 (5.6); 7.5202 (0.9); 7.2689 (5.3); 7.2617 (169.9); 7.2496 (1.5); 7.2455 (3.1); 7.2399 (2.8); 7.2302 (0.6); 6.9981 (1.3); 6.9824 (0.9); 6.8873 (3.6); 6.8748 (3.5); 6.6372 (0.7); 6.6315 (1.2); 6.6257 (0.6); 6.6153 (1.4); 6.6096 (2.3); 6.6039 (1.2); 6.5934 (0.7); 6.5877 (1.2); 6.5819 (0.5); 4.5265 (5.8); 4.5142 (5.7); 4.4689 (2.3); 4.4512 (7.2); 4.4335 (7.4); 4.4158 (2.3); 4.3212 (3.0); 4.2969 (3.2); 4.2719 (0.5); 4.2470 (0.6); 3.6256 (0.6); 3.6006 (0.6); 3.5822 (3.5); 3.5579 (3.3); 3.2100 (0.6); 3.2001 (3.0); 3.1667 (0.7); 3.1580 (3.3); 2.6000 (0.7); 2.5839 (3.8); 2.5568 (0.6); 2.5418 (3.3); 2.1347 (1.5); 2.1031 (2.4); 1.5803 (17.6); 1.5593 (4.3); 1.5418 (1.2); 1.4741 (8.0); 1.4564 (16.0); 1.4388 (8.0); 1.4252 (1.0); 1.3324 (0.6); 1.2843 (0.8); 1.2554 (1.1); 0.0080 (1.7); -0.0002 (49.8); -0.0084 (1.6) I.2-125:1H NMR (400.0MHz, CDCl3): δ= 8.1135 (2.5); 8.1121 (2.6); 8.1004 (2.5); 8.0989 (2.5); 7.5181 (1.7); 7.2921 (1.0); 7.2739 (1.3); 7.2592 (317.9); 7.2393 (2.8); 7.2337 (2.4); 6.9952 (1.7); 6.7391 (1.7); 6.7354 (1.8); 6.7259 (1.6); 6.7222 (1.7); 6.6422 (0.6); 6.6364 (1.1); 6.6306 (0.6); 6.6202 (1.2); 6.6145 (2.1); 6.6088 (1.1); 6.5982 (0.6); 6.5925 (1.1); 6.5869 (0.6); 6.5755 (2.3); 6.5736 (3.1); 6.5718 (3.0); 6.5700 (2.3); 5.9659 (0.6); 4.4614 (2.1); 4.4542 (2.1); 4.4466 (2.1); 4.4395 (2.0); 4.3823 (2.2); 4.3647 (7.0); 4.3470 (7.3); 4.3323 (2.8); 4.3294 (2.7); 4.3080 (2.7); 3.5699 (2.9); 3.5455 (2.8); 3.1470 (2.5); 3.1052 (2.9); 2.5534 (3.2); 2.5114 (2.8); 2.0985 (0.5); 1.5480 (14.6); 1.5347 (37.5); 1.4025 (7.5); 1.3848 (16.0); 1.3672 (7.2); 1.2565 (0.6); 0.0079 (3.9); 0.0063 (1.5); 0.0054 (1.6); -0.0002 (119.3); -0.0068 (1.4); -0.0085 (3.5) I.2-126:1H NMR (400.0 MHz, CDCl3): δ= 8.1155 (2.4); 8.1008 (2.5); 7.5892 (10.6); 7.5847 (11.1); 7.5180 (2.7); 7.2591 (510.6); 7.2509 (1.8); 7.2500 (1.5); 7.2493 (1.3); 7.2484 (1.3); 7.2476 (1.2); 7.2452 (0.8); 7.2436 (0.7); 7.2413 (0.6); 7.2341 (0.5); 7.1616 (2.9); 7.1570 (5.6); 7.1525 (2.7); 6.9952 (2.7); 6.7395 (1.6); 6.7358 (1.7); 6.7264 (1.5); 6.7227 (1.6); 6.5764 (2.3); 6.5746 (2.8); 6.5727 (2.8); 5.9585 (0.6); 4.4603 (1.9); 4.4532 (2.1); 4.4456 (2.0); 4.4385 (2.0); 4.3838 (2.0); 4.3661 (6.7); 4.3485 (6.8); 4.3389 (2.4); 4.3308 (2.2); 4.3145 (2.6); 3.5719 (2.8); 3.5478 (2.7); 3.1392 (2.4); 3.0972 (2.7); 2.5465 (3.1); 2.5045 (2.7); 2.0994 (0.6); 2.0428 (1.5); 1.5434 (14.3); 1.5330 (64.8); 1.4036 (7.6); 1.3860 (16.0); 1.3682 (7.2); 1.2761 (0.5); 1.2583 (1.3); 0.1460 (0.6); 0.0079 (5.7); 0.0062 (2.2); -0.0002 (186.9); -0.0060 (1.8); -0.0069 (1.5); -0.0085 (5.1); - 0.1497 (0.5) I.2-127:1H NMR (400.0 MHz, CDCl3): δ= 8.2233 (0.8); 8.2116 (0.8); 7.5974 (10.3); 7.5929 (10.8); 7.5191 (0.8); 7.2602 (137.9); 7.2098 (0.5); 7.1978 (0.5); 7.1573 (2.7); 7.1528 (4.8); 7.1483 (2.5); 6.9962 (0.8); 6.4868 (2.8); 6.4741 (2.8); 4.4197 (1.9); 4.4096 (2.5); 4.4011 (1.5); 4.3308 (2.6); 4.3065 (2.7); 4.1306 (0.6); 4.1128 (0.6); 3.5894 (3.2); 3.5650 (3.0); 3.1986 (2.4); 3.1564 (2.7); 3.0250 (7.9); 3.0127 (7.8); 2.5806 (3.6); 2.5384 (3.1); 2.1307 (0.9); 2.0985 (16.0); 2.0437 (3.0); 1.5864 (0.9); 1.5739 (13.8); 1.5468 (1.4); 1.3323 (1.1); 1.2842 (1.6); 1.2763 (1.2); 1.2584 (4.2); 1.2406 (1.1); 0.8800 (0.6); 0.0080 (1.6); -0.0002 (53.6); -0.0085 (1.9) I.2-129:1H NMR (400.0 MHz, CDCl3): δ= 8.1052 (1.3); 8.1038 (1.3); 8.0921 (1.3); 8.0906 (1.3); 7.5182 (0.6); 7.2749 (0.5); 7.2685 (0.8); 7.2594 (105.3); 7.2442 (0.6); 7.2399 (1.4); 7.2343 (1.2); 6.9954 (0.6); 6.7095 (0.9); 6.7058 (1.0); 6.6964 (0.9); 6.6926 (0.9); 6.6359 (0.6); 6.6196 (0.6); 6.6140 (1.1); 6.6083 (0.5); 6.5920 (0.6); 6.5303 (1.2); 6.5285 (1.6); 6.5266 (1.6); 6.5248 (1.2); 5.3181 (1.0); 5.3026 (1.4); 5.2871 (1.0); 4.4478 (1.2); 4.4435 (1.2); 4.4331 (1.2); 4.4307 (1.1); 4.4288 (1.2); 4.3331 (1.4); 4.3086 (1.5); 3.5694 (1.6); 3.5450 (1.5); 3.1490 (1.3); 3.1071 (1.5); 2.5512 (1.7); 2.5094 (1.5); 1.5470 (8.2); 1.5397 (15.6); 1.3445 (16.0); 1.3356 (0.9); 1.3290 (15.9); 0.0080 (1.2); 0.0055 (0.5); -0.0002 (38.2); -0.0085 (1.0) I.2-130:1H NMR (400.0MHz, CDCl3): δ= 8.2280 (0.9); 8.2149 (0.9); 7.5183 (1.4); 7.2834 (0.8); 7.2719 (3.8); 7.2661 (5.8); 7.2595 (247.0); 7.2536 (2.6); 7.2528 (2.6); 7.2503 (2.4); 7.2482 (3.6); 7.2426 (3.2); 7.2369 (0.8); 7.2313 (0.6); 7.2297 (0.5); 6.9955 (1.4); 6.6380 (0.7); 6.6323 (1.3); 6.6266 (0.6); 6.6160 (1.4); 6.6103 (2.5); 6.6046 (1.3); 6.5941 (0.8); 6.5884 (1.3); 6.5827 (0.6); 6.4843 (3.3); 6.4717 (3.3); 4.4205 (2.0); 4.4101 (2.6); 4.4021 (1.7); 4.3273 (3.0); 4.3030 (3.1); 4.1304 (0.6); 4.1126 (0.5); 3.5835 (3.7); 3.5592 (3.5); 3.2081 (2.7); 3.1660 (3.1); 3.0242 (11.6); 3.0116 (11.3); 2.5905 (0.7); 2.5855 (3.8); 2.5435 (3.3); 2.1938 (0.5); 2.1693 (0.5); 2.1312 (0.8); 2.0988 (16.0); 2.0430 (2.8); 1.5789 (15.9); 1.5531 (1.7); 1.3325 (1.2); 1.2842 (1.7); 1.2761 (1.0); 1.2582 (3.2); 1.2404 (0.9); 0.0079 (3.0); -0.0002 (99.8); -0.0060 (1.1); -0.0069 (0.9); -0.0085 (2.9) I.2-131:1H NMR (400.0 MHz, CDCl3): δ= 8.4817 (6.6); 8.4690 (6.8); 7.6056 (15.2); 7.6011 (16.0); 7.5186 (2.0); 7.3601 (0.8); 7.2918 (0.6); 7.2597 (357.0); 7.2547 (3.6); 7.2539 (2.5); 7.2531 (1.8); 7.2522 (1.5); 7.2514 (1.3); 7.2507 (1.1); 7.2498 (1.0); 7.2490 (0.8); 7.2483 (0.8); 7.2474 (0.7); 7.2467 (0.6); 7.1558 (4.0); 7.1513 (7.9); 7.1468 (3.9); 6.9957 (2.4); 6.9832 (0.9); 6.9065 (3.9); 6.8938 (3.9); 4.5245 (3.4); 4.5218 (3.4); 4.5124 (3.3); 4.5098 (3.4); 4.3262 (3.3); 4.3018 (3.5); 4.1304 (0.9); 4.1126 (1.0); 3.5856 (3.8); 3.5614 (3.7); 3.1984 (3.4); 3.1951 (3.2); 3.1766 (8.9); 3.1581 (10.7); 3.1398 (2.9); 2.5647 (4.2); 2.5226 (3.7); 2.0435 (4.6); 1.5788 (20.6); 1.4400 (9.8); 1.4216 (21.9); 1.4032 (9.6); 1.2765 (1.5); 1.2586 (3.3); 1.2407 (1.5); 0.0104 (0.6); 0.0095 (0.8); 0.0080 (4.2); 0.0065 (1.3); 0.0056 (1.4); 0.0048 (1.7); 0.0040 (2.3); 0.0031 (3.5); 0.0023 (5.6); -0.0002 (129.2); -0.0050 (1.9); -0.0058 (1.4); -0.0067 (1.2); -0.0085 (3.6); -0.0114 (0.6) I.2-132:1H NMR (400.0 MHz, CDCl3): δ= 8.1258 (1.5); 8.1242 (1.5); 8.1130 (1.5); 8.1113 (1.6); 7.5869 (6.8); 7.5824 (7.0); 7.5184 (0.7); 7.2596 (129.4); 7.1584 (1.7); 7.1539 (3.3); 7.1494 (1.6); 6.9956 (0.7); 6.3929 (1.0); 6.3895 (1.2); 6.3800 (1.0); 6.3766 (1.1); 6.3315 (1.9); 6.3301 (1.9); 4.4007 (1.3); 4.3880 (1.7); 4.3754 (1.3); 4.3400 (1.8); 4.3158 (1.8); 3.6067 (0.9); 3.5890 (3.0); 3.5713 (3.2); 3.5653 (2.2); 3.5536 (1.0); 3.5409 (1.9); 3.1334 (1.7); 3.0914 (1.9); 3.0211 (16.0); 2.5352 (2.2); 2.4933 (1.9); 2.0767 (2.2); 2.0429 (1.6); 1.5276 (9.1); 1.2761 (0.6); 1.2582 (1.4); 1.2404 (0.5); 1.1661 (3.8); 1.1484 (8.6); 1.1307 (3.8); 0.0079 (1.4); -0.0002 (52.0); - 0.0085 (1.6) I.2-133:1H NMR (400.0MHz, CDCl3): δ= 8.6204 (0.8); 8.6028 (15.9); 8.5901 (16.0); 7.5183 (7.1); 7.3601 (0.7); 7.3490 (0.7); 7.3220 (0.8); 7.3099 (2.5); 7.2909 (2.6); 7.2835 (3.4); 7.2721 (13.9); 7.2706 (12.4); 7.2659 (22.0); 7.2595 (1275.4); 7.2529 (11.4); 7.2512 (7.4); 7.2504 (7.7); 7.2487 (10.6); 7.2438 (15.8); 7.2369 (2.3); 7.2312 (11.2); 7.2249 (1.0); 7.2099 (1.7); 7.1598 (0.8); 6.9955 (6.9); 6.7503 (2.1); 6.6405 (1.8); 6.6348 (3.4); 6.6292 (1.8); 6.6186 (3.9); 6.6129 (6.9); 6.6072 (3.3); 6.5967 (2.1); 6.5910 (3.5); 6.5854 (1.6); 4.6415 (0.6); 4.5978 (9.4); 4.5950 (9.3); 4.5846 (9.0); 4.5818 (9.4); 4.3146 (8.9); 4.2901 (9.5); 4.1483 (0.7); 4.1304 (2.0); 4.1126 (1.8); 4.0949 (0.7); 3.5939 (10.4); 3.5695 (9.6); 3.1930 (8.6); 3.1508 (9.9); 2.5982 (11.2); 2.5561 (9.8); 2.1356 (0.6); 2.0434 (9.2); 1.5942 (48.4); 1.5343 (315.3); 1.4194 (1.4); 1.4020 (1.3); 1.3327 (1.2); 1.2842 (1.7); 1.2764 (3.0); 1.2585 (6.7); 1.2407 (2.7); 0.1460 (1.5); 0.0503 (0.9); 0.0080 (15.8); -0.0002 (525.0); -0.0085 (15.0); -0.0498 (0.8); -0.1496 (1.6) I.2-136:1H NMR (400.0MHz, CDCl3): δ= 8.0843 (12.6); 8.0712 (12.8); 7.5183 (4.9); 7.2946 (1.1); 7.2869 (1.9); 7.2751 (4.8); 7.2594 (869.3); 7.2445 (6.4); 7.2404 (13.8); 7.2347 (11.6); 7.2289 (2.6); 7.2261 (2.9); 7.2233 (1.7); 7.2159 (1.2); 6.9954 (4.7); 6.6872 (8.2); 6.6834 (8.5); 6.6741 (8.1); 6.6703 (8.2); 6.6406 (2.7); 6.6349 (5.1); 6.6292 (2.5); 6.6187 (5.5); 6.6130 (9.9); 6.6073 (4.9); 6.5967 (3.1); 6.5910 (5.0); 6.5854 (2.4); 6.5019 (11.7); 6.5001 (14.8); 6.4983 (14.4); 5.9232 (3.1); 4.4479 (0.9); 4.4235 (11.5); 4.4190 (11.5); 4.4088 (11.4); 4.4044 (11.2); 4.3800 (0.7); 4.3656 (0.7); 4.3322 (12.8); 4.3078 (13.5); 3.5657 (14.6); 3.5413 (13.8); 3.1488 (12.3); 3.1070 (13.9); 2.5450 (16.0); 2.5031 (14.1); 2.0041 (0.7); 1.7324 (1.1); 1.5918 (3.8); 1.5765 (394.5); 1.5533 (12.8); 1.5410 (74.1); 1.5360 (212.7); 1.4173 (1.8); 1.3727 (0.9); 1.3552 (0.8); 1.2839 (1.6); 1.2632 (3.4); 0.8987 (1.7); 0.8819 (5.1); 0.8644 (2.1); 0.1457 (1.1); 0.0080 (11.2); -0.0002 (335.7); -0.0085 (9.8); -0.0335 (0.7); -0.1496 (1.0) I.2-137:1H NMR (400.0 MHz, CDCl3): δ= 8.1245 (1.7); 8.1230 (1.6); 8.1117 (1.7); 8.1101 (1.6); 7.5185 (0.6); 7.2797 (0.6); 7.2724 (1.1); 7.2596 (116.4); 7.2514 (1.2); 7.2413 (0.8); 7.2373 (1.8); 7.2316 (1.6); 6.9956 (0.6); 6.6336 (0.7); 6.6174 (0.8); 6.6117 (1.4); 6.6060 (0.7); 6.5898 (0.7); 6.3935 (1.1); 6.3902 (1.2); 6.3806 (1.0); 6.3773 (1.1); 6.3330 (2.1); 4.4026 (1.4); 4.3899 (1.8); 4.3771 (1.3); 4.3356 (1.8); 4.3112 (1.9); 3.6070 (1.0); 3.5893 (3.1); 3.5716 (3.2); 3.5621 (2.2); 3.5539 (1.1); 3.5377 (1.9); 3.1412 (1.7); 3.0993 (2.0); 3.0351 (0.7); 3.0212 (16.0); 2.5413 (2.2); 2.4994 (1.9); 1.5519 (1.7); 1.5324 (10.1); 1.1657 (4.0); 1.1571 (0.6); 1.1480 (8.6); 1.1303 (3.8); 0.0080 (1.6); -0.0002 (45.7); -0.0085 (1.3) I.2-138:1H NMR (400.0MHz, CDCl3): δ= 8.1708 (6.2); 8.1693 (6.1); 8.1581 (6.3); 8.1565 (6.1); 7.5183 (3.8); 7.2985 (0.7); 7.2929 (1.3); 7.2794 (2.0); 7.2770 (2.9); 7.2755 (2.9); 7.2738 (3.4); 7.2722 (4.2); 7.2714 (4.7); 7.2691 (6.7); 7.2682 (7.0); 7.2674 (7.9); 7.2666 (8.9); 7.2594 (661.2); 7.2544 (9.0); 7.2536 (8.3); 7.2527 (9.4); 7.2505 (5.3); 7.2497 (4.0); 7.2488 (3.6); 7.2481 (3.5); 7.2465 (2.0); 7.2457 (1.5); 7.2449 (1.2); 7.2441 (1.3); 7.2433 (1.2); 7.2425 (1.1); 7.2409 (1.4); 7.2385 (2.9); 7.2345 (7.2); 7.2289 (6.2); 7.2233 (1.0); 7.2171 (1.0); 7.2098 (0.9); 6.9954 (3.6); 6.6436 (1.6); 6.6380 (2.8); 6.6322 (1.5); 6.6218 (3.1); 6.6160 (5.4); 6.6104 (2.6); 6.5998 (1.7); 6.5942 (2.7); 6.5884 (1.4); 6.5401 (4.1); 6.5368 (4.5); 6.5241 (4.5); 6.4974 (7.5); 5.9398 (1.6); 4.4177 (8.5); 4.4031 (8.2); 4.3318 (6.8); 4.3073 (7.1); 4.1479 (1.0); 4.1301 (2.8); 4.1122 (2.9); 4.0943 (1.0); 3.8264 (14.2); 3.8144 (16.0); 3.8018 (15.9); 3.5662 (7.9); 3.5418 (7.4); 3.5105 (15.9); 3.4978 (15.2); 3.4858 (13.0); 3.1259 (6.6); 3.0841 (7.5); 2.5532 (8.5); 2.5114 (7.3); 2.0861 (2.3); 2.0429 (13.5); 1.5573 (4.9); 1.5346 (38.4); 1.4291 (0.6); 1.4125 (0.6); 1.3492 (0.5); 1.3328 (0.6); 1.2839 (1.1); 1.2762 (4.2); 1.2584 (9.8); 1.2405 (4.1); 0.8804 (0.7); 0.1458 (0.7); 0.0079 (8.6); 0.0062 (4.0); -0.0002 (257.6); -0.0052 (3.1); -0.0060 (2.4); -0.0069 (2.3); -0.0085 (7.4); -0.0124 (0.8); -0.1496 (0.7) I.2-139:1H NMR (400.0MHz, CDCl3): δ= 8.0854 (3.9); 8.0842 (3.9); 8.0724 (4.0); 8.0711 (4.0); 7.5897 (15.8); 7.5852 (16.0); 7.5183 (1.1); 7.2594 (195.3); 7.2496 (0.7); 7.2480 (0.5); 7.1593 (4.0); 7.1548 (7.4); 7.1502 (3.8); 6.9954 (1.1); 6.6871 (2.6); 6.6833 (2.7); 6.6741 (2.5); 6.6703 (2.6); 6.5021 (3.5); 6.5004 (4.6); 6.4985 (4.5); 6.4968 (3.5); 5.9252 (1.0); 4.4214 (3.4); 4.4165 (3.5); 4.4069 (3.4); 4.4020 (3.4); 4.3377 (4.0); 4.3133 (4.2); 4.1295 (0.6); 4.1117 (0.6); 3.5673 (4.6); 3.5429 (4.3); 3.1401 (3.9); 3.0982 (4.4); 2.5367 (5.0); 2.4948 (4.4); 2.0964 (0.7); 2.0424 (2.7); 1.5916 (0.8); 1.5768 (130.4); 1.5534 (0.9); 1.5361 (26.4); 1.3042 (1.1); 1.2841 (1.5); 1.2758 (2.8); 1.2649 (5.4); 1.2582 (4.2); 1.2402 (1.2); 0.8989 (2.9); 0.8819 (10.6); 0.8642 (3.9); 0.0692 (0.5); 0.0080 (2.2); -0.0002 (80.5); -0.0085 (2.4) I.2-140:1H NMR (400.0 MHz, CDCl3): δ= 8.4522 (12.8); 8.4397 (13.0); 7.5198 (1.0); 7.2872 (1.2); 7.2797 (2.0); 7.2679 (10.7); 7.2609 (179.8); 7.2446 (8.3); 7.2391 (6.9); 7.2335 (1.4); 7.2274 (1.2); 7.2202 (0.5); 6.9968 (1.2); 6.9322 (2.5); 6.8524 (9.4); 6.8399 (9.1); 6.6350 (1.6); 6.6293 (2.9); 6.6236 (1.6); 6.6131 (3.3); 6.6073 (5.7); 6.6017 (2.9); 6.5911 (1.8); 6.5854 (2.9); 6.5797 (1.4); 5.3166 (1.9); 5.3009 (5.4); 5.2987 (4.8); 5.2855 (6.6); 5.2700 (4.9); 5.2545 (2.0); 4.5147 (16.0); 4.5026 (15.8); 4.3190 (8.1); 4.2947 (8.6); 3.5772 (9.3); 3.5529 (8.8); 3.1987 (7.9); 3.1565 (8.9); 2.5752 (10.1); 2.5497 (1.0); 2.5332 (8.9); 2.2833 (0.6); 2.1941 (0.8); 2.1295 (3.7); 2.0988 (0.9); 1.5769 (46.6); 1.4381 (2.8); 1.4262 (39.2); 1.4108 (38.7); 1.3328 (1.9); 1.2842 (2.7); 1.2568 (5.4); 0.8966 (0.7); 0.8803 (1.8); 0.8628 (0.9); 0.0079 (2.2); -0.0002 (64.4); -0.0084 (2.5) I.2-141:1H NMR (400.0MHz, CDCl3): δ= 8.1581 (7.2); 8.1451 (7.3); 7.6430 (7.5); 7.5192 (1.0); 7.4607 (16.0); 7.2784 (8.4); 7.2734 (1.7); 7.2604 (179.0); 7.2545 (7.7); 7.2489 (7.7); 7.2449 (2.8); 7.2352 (3.1); 7.2310 (7.6); 7.2254 (6.4); 7.2196 (1.1); 7.2138 (1.0); 6.9963 (1.2); 6.9888 (5.1); 6.9869 (4.3); 6.9851 (5.1); 6.9757 (4.8); 6.9739 (4.1); 6.9721 (4.9); 6.7545 (7.1); 6.7527 (8.9); 6.7510 (8.7); 6.7492 (6.5); 6.6465 (1.8); 6.6408 (3.2); 6.6351 (1.6); 6.6246 (3.6); 6.6189 (6.3); 6.6132 (3.1); 6.6027 (1.9); 6.5970 (3.1); 6.5913 (1.5); 6.1294 (1.7); 4.5629 (1.1); 4.5477 (1.2); 4.5232 (5.4); 4.5079 (5.9); 4.5057 (5.6); 4.5036 (5.8); 4.4884 (5.3); 4.4637 (1.2); 4.4488 (1.1); 4.3260 (7.7); 4.3015 (8.2); 4.1279 (0.7); 4.1101 (0.7); 3.5829 (9.0); 3.5585 (8.5); 3.1317 (7.5); 3.0898 (8.6); 2.5680 (9.8); 2.5262 (8.4); 2.1312 (0.7); 2.0420 (3.4); 1.5614 (42.6); 1.5545 (28.0); 1.2817 (0.7); 1.2756 (1.2); 1.2577 (3.0); 1.2399 (1.1); 0.0079 (2.3); -0.0002 (67.0); -0.0085 (1.9) I.2-142:1H NMR (400.0MHz, CDCl3): δ= 8.3342 (2.9); 8.3215 (2.9); 7.4361 (1.8); 7.4323 (3.2); 7.4276 (1.9); 7.2872 (2.9); 7.2628 (37.6); 7.1940 (3.5); 7.1924 (3.5); 7.1048 (2.0); 7.1031 (1.8); 7.1012 (1.9); 7.0920 (1.9); 7.0885 (1.8); 6.9815 (3.0); 6.3794 (0.8); 4.4895 (2.2); 4.4756 (3.7); 4.4614 (2.1); 4.3291 (3.1); 4.3044 (3.3); 4.1440 (0.9); 4.1262 (2.6); 4.1083 (2.7); 4.0904 (0.9); 3.5933 (3.6); 3.5686 (3.4); 3.0964 (2.9); 3.0547 (3.3); 2.9516 (0.9); 2.8673 (0.8); 2.5411 (3.7); 2.4994 (3.2); 2.3330 (16.0); 2.3320 (15.8); 2.0412 (12.3); 1.5458 (16.6); 1.2815 (0.5); 1.2752 (3.6); 1.2573 (8.0); 1.2395 (3.5); -0.0002 (13.4) I.2-143:1H NMR (400.0MHz, CDCl3): δ= 8.4912 (2.5); 8.4784 (2.5); 7.6050 (5.7); 7.6004 (5.8); 7.5185 (0.8); 7.2597 (139.2); 7.2474 (0.6); 7.2096 (0.6); 7.1563 (1.4); 7.1517 (2.7); 7.1473 (1.4); 6.9957 (1.0); 6.9162 (1.7); 6.9034 (1.7); 4.5299 (2.0); 4.5176 (2.0); 4.3262 (1.5); 4.3019 (1.6); 4.1305 (0.8); 4.1126 (0.8); 3.5883 (1.8); 3.5640 (1.6); 3.1986 (1.5); 3.1565 (1.7); 2.5810 (16.0); 2.5707 (2.0); 2.5286 (1.7); 2.0435 (3.8); 1.5815 (8.6); 1.5563 (2.2); 1.2765 (1.1); 1.2586 (2.4); 1.2407 (1.1); 0.0080 (1.8); -0.0002 (55.4); -0.0085 (1.8) I.2-144:1H NMR (400.0 MHz, CDCl3): δ= 8.3258 (11.8); 8.3130 (12.0); 7.5643 (10.6); 7.5613 (14.0); 7.5565 (4.0); 7.5422 (16.0); 7.5401 (14.8); 7.5343 (1.8); 7.5214 (0.9); 7.3967 (2.1); 7.3919 (12.9); 7.3866 (4.1); 7.3785 (2.8); 7.3732 (17.0); 7.3709 (13.0); 7.3654 (2.1); 7.3564 (4.6); 7.3517 (12.6); 7.3463 (1.5); 7.2746 (0.5); 7.2738 (0.5); 7.2731 (0.6); 7.2723 (0.6); 7.2698 (1.1); 7.2624 (148.7); 7.2008 (4.9); 7.1979 (12.6); 7.1949 (16.5); 7.1927 (14.2); 7.1831 (4.3); 7.1795 (11.4); 7.1758 (3.8); 7.1637 (3.0); 7.1609 (5.3); 7.1581 (2.7); 7.1004 (7.8); 7.0986 (6.8); 7.0968 (7.4); 7.0876 (7.6); 7.0859 (6.5); 7.0840 (7.1); 6.9984 (0.9); 6.4489 (2.5); 5.2977 (3.6); 4.5194 (1.5); 4.5041 (1.5); 4.4797 (8.0); 4.4639 (14.8); 4.4483 (7.9); 4.4235 (1.5); 4.4087 (1.4); 4.3672 (12.7); 4.3423 (13.5); 3.6248 (15.0); 3.6000 (14.1); 3.0962 (11.7); 3.0546 (13.4); 2.5431 (14.9); 2.5016 (13.0); 2.3141 (0.7); 2.3059 (0.6); 2.2632 (1.5); 2.0409 (1.3); 1.6433 (10.2); 1.5486 (66.9); 1.3286 (1.1); 1.2812 (1.7); 1.2747 (0.6); 1.2569 (3.7); 1.2390 (0.5); 0.8799 (0.7); 0.0079 (1.6); 0.0063 (0.6); -0.0002 (53.1); -0.0085 (1.5) I.2-145:1H NMR (400.0MHz, CDCl3): δ= 8.1134 (3.0); 8.1119 (3.0); 8.1002 (3.0); 8.0988 (3.1); 7.5874 (12.6); 7.5829 (13.0); 7.5189 (0.8); 7.2601 (135.1); 7.1607 (3.2); 7.1561 (5.9); 7.1516 (3.0); 6.9961 (0.8); 6.7371 (2.1); 6.7333 (2.2); 6.7239 (2.0); 6.7201 (2.1); 6.5877 (2.9); 6.5860 (3.7); 6.5841 (3.6); 6.5823 (2.8); 5.9868 (0.8); 4.4587 (2.5); 4.4513 (2.6); 4.4440 (2.5); 4.4366 (2.5); 4.3387 (3.1); 4.3143 (3.3); 4.2620 (4.9); 4.2451 (10.4); 4.2282 (5.0); 3.5727 (3.6); 3.5484 (3.4); 3.1391 (3.1); 3.0972 (3.5); 2.5458 (4.0); 2.5039 (3.5); 2.1316 (0.9); 2.0955 (2.2); 2.0426 (2.2); 1.8337 (0.6); 1.8151 (2.1); 1.7981 (4.2); 1.7796 (4.4); 1.7625 (2.2); 1.7442 (0.6); 1.5432 (19.7); 1.4236 (0.5); 1.2760 (0.8); 1.2581 (2.1); 1.2402 (0.7); 1.0364 (7.8); 1.0179 (16.0); 0.9993 (7.0); 0.0080 (1.6); 0.0065 (0.6); 0.0055 (0.6); -0.0002 (50.7); -0.0066 (0.7); -0.0085 (1.5) I.2-146:1H NMR (400.0MHz, CDCl3): δ= 8.0981 (3.9); 8.0968 (3.8); 8.0849 (3.9); 8.0836 (3.9); 7.5884 (15.6); 7.5838 (16.0); 7.5188 (1.1); 7.2599 (197.9); 7.1615 (4.0); 7.1570 (7.5); 7.1525 (3.8); 6.9959 (1.1); 6.7299 (2.6); 6.7262 (2.7); 6.7167 (2.5); 6.7130 (2.6); 6.5474 (3.6); 6.5457 (4.6); 6.5438 (4.5); 6.5421 (3.4); 5.9735 (1.0); 5.1931 (1.7); 5.1910 (1.1); 5.1757 (2.3); 5.1735 (2.3); 5.1582 (1.1); 5.1561 (1.7); 5.1539 (1.1); 4.4514 (3.2); 4.4444 (3.3); 4.4366 (3.2); 4.4296 (3.1); 4.3370 (4.0); 4.3126 (4.2); 4.1295 (0.7); 4.1117 (0.7); 3.5710 (4.6); 3.5467 (4.3); 3.1375 (3.9); 3.0956 (4.4); 2.5438 (5.0); 2.5019 (4.4); 2.4878 (0.9); 2.4811 (1.2); 2.4740 (0.9); 2.4703 (1.1); 2.4677 (1.3); 2.4638 (1.9); 2.4608 (1.7); 2.4572 (2.0); 2.4504 (2.0); 2.4436 (2.1); 2.4399 (1.8); 2.4370 (2.2); 2.4331 (1.4); 2.4306 (1.3); 2.4267 (1.0); 2.4195 (1.4); 2.4131 (1.0); 2.1731 (0.5); 2.1522 (1.0); 2.1475 (2.1); 2.1406 (1.4); 2.1325 (1.0); 2.1281 (2.1); 2.1234 (2.1); 2.1214 (2.1); 2.1167 (1.8); 2.1040 (1.5); 2.0968 (2.4); 2.0926 (1.0); 2.0794 (0.6); 2.0732 (0.6); 2.0427 (3.4); 1.8492 (0.9); 1.8460 (1.3); 1.8434 (1.0); 1.8393 (0.6); 1.8265 (0.7); 1.8242 (0.8); 1.8214 (1.3); 1.8188 (1.1); 1.7299 (0.5); 1.7097 (1.0); 1.7037 (0.8); 1.6894 (0.6); 1.6842 (1.9); 1.6790 (0.8); 1.6633 (0.8); 1.6588 (1.1); 1.6568 (1.5); 1.6370 (0.6); 1.6314 (0.7); 1.5420 (30.2); 1.2839 (0.5); 1.2760 (1.1); 1.2582 (2.8); 1.2403 (1.0); 0.0080 (2.6); -0.0002 (78.9); -0.0085 (2.4) I.2-147:1H NMR (400.0 MHz, CDCl3): δ= 8.4829 (10.6); 8.4702 (10.8); 7.5184 (4.5); 7.3099 (1.8); 7.2961 (1.2); 7.2767 (7.4); 7.2709 (10.2); 7.2596 (841.7); 7.2536 (10.2); 7.2489 (4.4); 7.2473 (6.3); 7.2417 (1.4); 7.2361 (0.9); 7.2282 (0.7); 7.2257 (0.8); 6.9956 (5.9); 6.9087 (6.6); 6.8959 (6.4); 6.6365 (1.5); 6.6309 (2.5); 6.6252 (1.3); 6.6147 (3.0); 6.6090 (5.0); 6.6032 (2.5); 6.5927 (1.4); 6.5870 (2.6); 6.5813 (1.2); 4.5256 (8.0); 4.5136 (8.0); 4.3192 (5.8); 4.2948 (6.3); 3.5805 (7.0); 3.5561 (6.4); 3.2054 (5.9); 3.1957 (4.8); 3.1772 (15.2); 3.1633 (7.2); 3.1588 (16.0); 3.1405 (4.9); 2.5717 (7.3); 2.5297 (6.5); 2.1011 (0.6); 2.0435 (1.0); 1.5835 (34.8); 1.5642 (10.6); 1.4396 (16.9); 1.4212 (35.9); 1.4028 (16.3); 1.3332 (0.6); 1.2843 (0.9); 1.2767 (0.8); 1.2585 (1.5); 0.1458 (0.9); 0.0079 (9.8); 0.0063 (3.7); 0.0054 (4.1); -0.0002 (313.2); -0.0060 (3.1); -0.0068 (2.5); - 0.0085 (8.9); -0.1496 (0.9) I.2-148:1H NMR (400.0MHz, CDCl3): δ= 8.1075 (1.3); 8.0944 (1.4); 7.5901 (6.2); 7.5856 (6.3); 7.5185 (0.7); 7.2596 (122.2); 7.2537 (0.8); 7.2529 (0.6); 7.1611 (1.5); 7.1566 (2.9); 7.1521 (1.4); 6.9956 (0.7); 6.7117 (0.9); 6.7081 (0.9); 6.6985 (0.8); 6.6949 (0.8); 6.5313 (1.6); 6.5295 (1.5); 5.3196 (1.0); 5.3041 (1.3); 5.2887 (1.0); 4.4476 (1.1); 4.4429 (1.1); 4.4331 (1.1); 4.4283 (1.1); 4.3398 (1.4); 4.3154 (1.5); 3.5717 (1.6); 3.5474 (1.5); 3.1417 (1.3); 3.0998 (1.5); 2.5446 (1.7); 2.5027 (1.5); 2.0427 (1.8); 1.5426 (14.6); 1.3463 (16.0); 1.3308 (15.9); 1.2760 (0.6); 1.2581 (1.4); 1.2403 (0.5); 0.0079 (1.4); 0.0054 (0.5); 0.0046 (0.6); -0.0002 (45.4); -0.0027 (2.4); -0.0052 (0.6); -0.0085 (1.3) I.2-149:1H NMR (400.0MHz, CDCl3): δ= 8.4536 (7.5); 8.4411 (7.6); 7.5944 (15.8); 7.5899 (16.0); 7.5186 (1.6); 7.2930 (0.9); 7.2597 (286.6); 7.1540 (4.1); 7.1495 (7.6); 7.1450 (3.9); 6.9957 (1.9); 6.9158 (1.5); 6.8519 (5.4); 6.8395 (5.3); 5.3165 (1.1); 5.3010 (2.8); 5.2855 (3.9); 5.2700 (2.9); 5.2544 (1.1); 4.5137 (9.4); 4.5016 (9.1); 4.3235 (4.7); 4.2993 (4.9); 4.1303 (0.6); 4.1123 (0.6); 3.5778 (5.3); 3.5535 (5.0); 3.1889 (4.6); 3.1467 (5.1); 2.5679 (5.9); 2.5494 (0.6); 2.5258 (5.1); 2.2832 (0.9); 2.2604 (0.5); 2.1940 (0.9); 2.1336 (2.7); 2.1008 (1.2); 2.0432 (2.8); 1.5720 (25.5); 1.5434 (11.9); 1.4392 (2.0); 1.4283 (25.1); 1.4128 (24.7); 1.3328 (1.0); 1.2841 (1.8); 1.2763 (1.6); 1.2586 (6.9); 1.2407 (1.3); 0.8970 (1.0); 0.8804 (2.5); 0.8628 (1.2); 0.8311 (0.7); 0.0080 (3.7); -0.0002 (112.2); -0.0085 (3.6) I.2-150:1H NMR (400.0 MHz, CDCl3): δ= 8.1318 (12.7); 8.1185 (12.7); 7.5181 (9.6); 7.2592 (1670.0); 7.2417 (16.3); 7.2361 (11.8); 7.2095 (2.1); 7.0964 (84.4); 7.0810 (51.0); 6.9952 (9.4); 6.8758 (8.9); 6.8592 (8.0); 6.7618 (14.9); 6.6444 (3.0); 6.6388 (4.7); 6.6228 (5.4); 6.6169 (8.9); 6.6116 (4.7); 6.5952 (4.8); 6.0423 (3.6); 4.5259 (9.9); 4.5124 (16.0); 4.4978 (9.0); 4.3344 (12.5); 4.3098 (13.0); 4.1306 (3.6); 4.1125 (3.3); 3.5821 (14.4); 3.5577 (12.9); 3.1378 (11.9); 3.0961 (13.4); 2.5712 (15.4); 2.5296 (13.1); 2.0433 (15.1); 2.0043 (2.0); 1.5579 (71.3); 1.5323 (327.0); 1.3330 (2.1); 1.2763 (4.7); 1.2585 (10.4); 1.2408 (4.2); 0.1463 (2.7); 0.0080 (31.6); -0.0002 (649.8); -0.0085 (27.5); -0.1497 (3.0) I.2-151:1H NMR (400.0 MHz, CDCl3): δ= 8.1343 (3.4); 8.1212 (3.4); 7.5906 (15.5); 7.5861 (16.0); 7.5181 (3.7); 7.3496 (1.1); 7.3106 (0.8); 7.2938 (1.2); 7.2903 (0.7); 7.2871 (0.9); 7.2752 (1.9); 7.2744 (1.9); 7.2736 (2.1); 7.2728 (2.2); 7.2704 (3.0); 7.2687 (4.2); 7.2680 (4.7); 7.2672 (5.2); 7.2593 (645.7); 7.2527 (4.4); 7.2519 (3.3); 7.2510 (2.4); 7.2502 (1.9); 7.2494 (1.7); 7.2486 (1.7); 7.2478 (1.5); 7.2470 (1.2); 7.2462 (1.1); 7.2454 (0.8); 7.2446 (0.8); 7.2438 (0.7); 7.2430 (0.5); 7.2093 (3.5); 7.1632 (3.8); 7.1588 (7.8); 7.1542 (3.6); 7.1396 (1.0); 7.0979 (27.8); 7.0815 (14.0); 6.9952 (3.6); 6.8758 (2.1); 6.8625 (2.1); 6.7611 (4.0); 6.0465 (0.9); 4.5238 (2.2); 4.5106 (3.5); 4.4971 (2.2); 4.3402 (3.5); 4.3157 (3.8); 4.1482 (0.5); 4.1303 (1.6); 4.1125 (1.7); 4.0945 (0.5); 3.5848 (4.2); 3.5604 (3.9); 3.1284 (3.4); 3.0865 (3.7); 2.5649 (4.2); 2.5230 (3.6); 2.1350 (1.2); 2.0989 (1.5); 2.0431 (8.0); 1.5523 (25.0); 1.4392 (0.7); 1.4250 (0.7); 1.2840 (0.5); 1.2763 (2.4); 1.2584 (5.4); 1.2406 (2.3); 0.1571 (0.6); 0.1458 (0.7); 0.0159 (0.5); 0.0151 (0.5); 0.0135 (0.6); 0.0127 (0.7); 0.0119 (0.8); 0.0080 (7.9); 0.0064 (2.7); 0.0055 (3.0); 0.0047 (3.5); -0.0002 (250.2); -0.0067 (2.9); -0.0085 (7.4); -0.0501 (1.5); -0.1495 (0.8) I.2-152:1H NMR (400.0MHz, CDCl3): δ= 7.7496 (12.3); 7.7037 (5.6); 7.4379 (0.5); 7.4205 (1.5); 7.4018 (1.3); 7.3809 (0.7); 7.3631 (0.7); 7.3020 (0.6); 7.2979 (0.6); 7.2895 (2.2); 7.2813 (1.6); 7.2749 (4.5); 7.2717 (4.7); 7.2598 (62.0); 7.1850 (4.2); 7.1654 (3.5); 7.1616 (2.7); 5.3602 (1.5); 5.3570 (1.6); 5.2846 (0.8); 4.8147 (1.7); 4.7782 (1.9); 4.6590 (0.6); 4.6172 (1.0); 4.5167 (1.1); 4.4751 (0.6); 4.3674 (2.6); 4.3534 (2.2); 4.3170 (1.8); 4.2413 (1.4); 3.4889 (0.8); 3.2271 (4.0); 3.1932 (1.9); 2.9746 (1.5); 2.9609 (9.4); 2.9515 (16.0); 2.9379 (0.9); 2.9253 (0.8); 2.7717 (0.5); 2.7655 (0.6); 2.7596 (0.6); 2.7535 (0.7); 2.7475 (0.6); 1.8688 (4.7); 1.8642 (6.5); 1.8590 (4.6); 1.7485 (2.5); 1.7439 (3.5); 1.7391 (2.4); 1.5557 (3.8); 1.2048 (6.5); 1.1866 (6.4); 1.1433 (3.3); 1.1251 (3.2); 0.0080 (0.8); -0.0002 (23.6); -0.0085 (0.7) I.2-153:1H NMR (400.0MHz, CDCl3): δ= 7.7081 (0.6); 7.6862 (16.0); 7.2611 (75.9); 6.6132 (0.7); 5.3506 (1.9); 4.5333 (2.7); 4.4471 (1.6); 3.5554 (1.1); 3.5462 (1.3); 3.5380 (1.2); 3.5295 (1.2); 3.4893 (2.7); 3.0063 (4.9); 2.7471 (0.6); 1.8541 (6.2); 1.8497 (8.1); 1.8441 (5.9); 1.3093 (4.8); 1.2912 (9.9); 1.2730 (4.8); 1.1800 (5.6); 1.1618 (5.5); 0.0080 (0.8); -0.0002 (29.0); -0.0085 (0.9) I.2-154:1H NMR (400.0 MHz, CDCl3): δ= 8.0493 (0.5); 8.0281 (0.6); 7.6706 (0.5); 7.5454 (1.0); 7.5409 (1.0); 7.5199 (1.8); 7.5142 (8.6); 7.5098 (9.0); 7.4902 (0.7); 7.4352 (0.5); 7.4315 (0.6); 7.2611 (114.7); 7.1132 (1.2); 7.1087 (1.8); 7.1041 (2.0); 6.9971 (0.7); 6.2263 (3.6); 5.3427 (2.3); 4.5394 (3.1); 4.4511 (1.8); 3.5589 (1.4); 3.5439 (1.8); 3.5280 (1.6); 3.5103 (1.0); 3.4889 (3.8); 3.0062 (4.2); 2.7462 (0.8); 1.9322 (0.6); 1.9279 (0.8); 1.9224 (0.6); 1.8424 (7.4); 1.8370 (10.1); 1.8324 (7.9); 1.5646 (0.8); 1.3094 (7.7); 1.2912 (16.0); 1.2731 (8.0); 1.2585 (1.3); 1.2479 (0.9); 1.2250 (0.7); 1.2088 (1.0); 1.1820 (5.2); 1.1639 (5.2); 0.0080 (1.0); -0.0002 (44.7); - 0.0085 (1.7) I.2-155:1H NMR (400.0MHz, CDCl3): δ= 8.2917 (1.6); 8.2791 (1.6); 7.6849 (16.0); 7.5189 (0.5); 7.2600 (94.6); 7.1345 (2.4); 7.0376 (1.4); 7.0342 (1.3); 7.0249 (1.4); 7.0214 (1.3); 6.9960 (0.5); 6.1709 (0.7); 5.3667 (1.5); 5.3636 (1.5); 4.5395 (2.4); 4.4676 (1.5); 4.4523 (1.5); 4.4414 (1.5); 4.4263 (1.5); 3.0025 (3.9); 2.9438 (1.2); 2.9315 (1.4); 2.7743 (0.5); 2.7683 (0.6); 2.7623 (0.6); 2.7561 (0.6); 1.8676 (4.9); 1.8633 (6.4); 1.8620 (6.4); 1.8576 (4.9); 1.5568 (3.7); 1.2023 (7.3); 1.1841 (7.2); 0.0080 (1.2); -0.0002 (37.2); -0.0085 (1.0) I.2-156:1H NMR (400.0MHz, CDCl3): δ= 8.1126 (3.6); 8.1111 (3.6); 8.0994 (3.7); 8.0980 (3.7); 7.5862 (16.0); 7.5817 (16.0); 7.5186 (1.2); 7.2727 (0.8); 7.2597 (218.9); 7.2101 (0.6); 7.1633 (4.0); 7.1588 (7.5); 7.1543 (3.8); 6.9957 (1.2); 6.8649 (2.5); 6.8613 (2.6); 6.8517 (2.4); 6.8481 (2.4); 6.7258 (3.4); 6.7241 (4.3); 6.7224 (4.3); 6.7206 (3.2); 6.0378 (0.9); 4.7958 (2.9); 4.7744 (9.3); 4.7530 (9.6); 4.7316 (3.2); 4.4954 (2.7); 4.4820 (3.9); 4.4686 (2.7); 4.3390 (3.8); 4.3146 (4.0); 4.1295 (1.0); 4.1117 (1.0); 3.5814 (4.4); 3.5571 (4.2); 3.1337 (3.6); 3.0918 (4.2); 2.5579 (4.7); 2.5161 (4.1); 2.0961 (0.6); 2.0427 (4.6); 1.5539 (25.0); 1.2760 (1.6); 1.2581 (3.6); 1.2403 (1.4); 0.8818 (0.6); 0.0079 (2.4); 0.0063 (0.8); 0.0054 (0.9); -0.0002 (82.2); -0.0068 (1.0); - 0.0085 (2.5) I.2-157:1H NMR (400.0MHz, CDCl3): δ= 8.1716 (3.6); 8.1702 (3.6); 8.1589 (3.7); 8.1574 (3.6); 7.5832 (15.9); 7.5787 (16.0); 7.5186 (1.6); 7.2840 (0.6); 7.2597 (296.4); 7.2098 (0.6); 7.1627 (3.9); 7.1581 (7.4); 7.1536 (3.7); 6.9957 (1.6); 6.5399 (2.4); 6.5366 (2.8); 6.5271 (2.3); 6.5238 (2.7); 6.4966 (4.6); 5.9512 (1.0); 4.4158 (5.5); 4.4012 (5.4); 4.3369 (4.0); 4.3125 (4.2); 4.1300 (1.0); 4.1122 (1.0); 3.8271 (8.4); 3.8151 (9.7); 3.8025 (9.7); 3.5698 (4.7); 3.5455 (4.5); 3.5100 (9.3); 3.4974 (9.1); 3.4854 (7.9); 3.1183 (4.0); 3.0763 (4.6); 2.5478 (5.1); 2.5059 (4.4); 2.0736 (10.5); 2.0430 (4.8); 1.6917 (0.6); 1.5846 (0.6); 1.5298 (21.4); 1.4288 (0.6); 1.4125 (0.6); 1.3327 (0.7); 1.2840 (0.9); 1.2762 (1.6); 1.2583 (4.1); 1.2405 (1.5); 0.0080 (3.5); 0.0055 (1.4); - 0.0002 (116.3); -0.0067 (1.6); -0.0085 (3.6) I.2-158:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.6611 (1.1); 8.6467 (2.2); 8.6331 (1.1); 7.7180 (1.0); 7.7100 (9.8); 7.7045 (3.0); 7.6929 (3.2); 7.6873 (11.7); 7.6793 (1.2); 7.4610 (2.8); 7.4578 (2.2); 7.4432 (5.5); 7.4382 (16.0); 7.4326 (4.8); 7.4209 (3.2); 7.4154 (11.0); 7.4108 (2.2); 7.3799 (1.0); 7.3741 (1.7); 7.3612 (3.6); 7.3567 (6.1); 7.3530 (3.9); 7.3481 (2.1); 7.3395 (6.1); 7.3353 (4.3); 7.3259 (4.6); 7.3219 (3.8); 7.3190 (3.4); 7.3077 (3.2); 7.3014 (2.5); 7.2962 (1.3); 7.2899 (1.9); 7.2838 (1.0); 7.2769 (1.0); 7.2713 (0.9); 6.6088 (0.9); 6.5930 (0.5); 4.3885 (7.4); 4.3741 (7.3); 4.3073 (3.0); 4.2921 (3.0); 4.0547 (2.0); 4.0331 (3.1); 4.0305 (3.5); 4.0090 (2.9); 3.9202 (2.9); 3.9052 (3.1); 3.8959 (2.1); 3.8808 (2.3); 3.3877 (0.5); 3.3653 (1.1); 3.3483 (1.7); 3.3321 (1.2); 3.3130 (31.9); 2.8194 (2.0); 2.7962 (1.9); 2.7770 (4.0); 2.7537 (3.7); 2.7133 (4.0); 2.6954 (3.7); 2.6708 (2.1); 2.6530 (1.8); 2.5232 (1.3); 2.5184 (1.9); 2.5098 (23.8); 2.5052 (51.3); 2.5006 (71.1); 2.4960 (49.8); 2.4915 (22.6); 2.0852 (1.0); 2.0726 (1.0); 0.0080 (0.7); -0.0002 (21.6); -0.0085 (0.7) I.2-159:1H NMR (400.0MHz, d6-DMSO): δ= 8.6886 (1.3); 8.6749 (2.7); 8.6609 (1.4); 7.7131 (1.2); 7.7050 (11.0); 7.6995 (3.5); 7.6878 (3.7); 7.6823 (13.4); 7.6743 (1.5); 7.6200 (8.0); 7.6149 (8.5); 7.4424 (4.0); 7.4379 (16.0); 7.4324 (4.2); 7.4215 (8.8); 7.4158 (14.9); 7.4073 (1.3); 7.3880 (7.8); 7.3673 (3.6); 4.3579 (7.8); 4.3436 (7.7); 4.0470 (2.3); 4.0253 (3.6); 4.0227 (3.9); 4.0012 (3.1); 3.9096 (3.2); 3.8944 (3.4); 3.8852 (2.5); 3.8703 (2.5); 3.3764 (0.6); 3.3549 (1.2); 3.3378 (2.2); 3.3150 (48.9); 2.8146 (2.2); 2.7914 (2.2); 2.7722 (4.4); 2.7489 (4.0); 2.7038 (4.4); 2.6859 (4.1); 2.6613 (2.3); 2.6435 (2.0); 2.5236 (2.4); 2.5102 (37.8); 2.5056 (80.0); 2.5010 (110.0); 2.4964 (76.6); 2.4918 (34.5); 2.3278 (0.6); 2.0855 (1.5); 2.0731 (4.0); -0.0002 (6.2) I.2-160: 1H NMR (400.0 MHz, d6-DMSO): δ= 8.6770 (1.3); 8.6624 (2.5); 8.6477 (1.3); 7.7140 (1.2); 7.7059 (12.4); 7.7004 (3.8); 7.6887 (3.9); 7.6831 (15.0); 7.6751 (1.6); 7.4439 (1.4); 7.4359 (16.0); 7.4304 (4.3); 7.4187 (4.0); 7.4132 (13.1); 7.4050 (2.2); 7.3985 (10.0); 7.3934 (3.6); 7.3823 (4.3); 7.3771 (16.0); 7.3709 (2.2); 7.3100 (1.7); 7.3039 (12.0); 7.2986 (3.4); 7.2874 (2.8); 7.2823 (7.7); 4.3030 (8.1); 4.2883 (8.1); 4.0343 (2.6); 4.0127 (3.8); 4.0102 (4.4); 3.9886 (3.6); 3.9012 (3.7); 3.8860 (3.9); 3.8770 (2.7); 3.8618 (2.8); 3.3356 (0.8); 3.3121 (54.3); 3.3026 (1.8); 3.2967 (2.2); 3.2803 (1.5); 3.2759 (1.2); 3.2574 (0.6); 2.8005 (2.5); 2.7773 (2.3); 2.7581 (5.2); 2.7348 (4.7); 2.6955 (5.1); 2.6775 (4.8); 2.6699 (0.8); 2.6531 (2.3); 2.6350 (2.3); 2.5233 (1.8); 2.5185 (2.6); 2.5099 (38.4); 2.5053 (84.1); 2.5007 (118.2); 2.4960 (82.7); 2.4914 (37.2); 2.3275 (0.7); 2.3229 (0.5); -0.0002 (7.1) I.2-161:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5536 (0.6); 7.7055 (2.8); 7.7000 (0.9); 7.6883 (0.9); 7.6827 (3.4); 7.4339 (3.5); 7.4283 (1.0); 7.4166 (0.9); 7.4112 (3.1); 7.2038 (2.1); 7.1985 (0.7); 7.1873 (0.7); 7.1819 (2.4); 6.8975 (3.0); 6.8921 (0.9); 6.8809 (0.8); 6.8757 (2.6); 4.2411 (1.9); 4.2266 (1.9); 4.0226 (0.6); 4.0009 (0.9); 3.9984 (1.0); 3.9769 (0.8); 3.8915 (0.8); 3.8763 (0.9); 3.8672 (0.6); 3.8521 (0.6); 3.7290 (16.0); 3.3144 (6.9); 2.7850 (0.5); 2.7426 (1.2); 2.7194 (1.1); 2.6863 (1.2); 2.6683 (1.1); 2.6439 (0.5); 2.5097 (5.2); 2.5052 (11.3); 2.5005 (15.7); 2.4959 (11.0); 2.4913 (5.0); -0.0002 (0.9) I.2-164:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.6635 (0.8); 8.6483 (1.5); 8.6324 (0.8); 7.5306 (5.6); 7.5260 (1.9); 7.5142 (2.0); 7.5093 (6.6); 7.4047 (0.6); 7.3983 (5.8); 7.3932 (2.1); 7.3822 (2.5); 7.3769 (9.5); 7.3707 (1.3); 7.3029 (6.9); 7.2976 (2.0); 7.2864 (1.7); 7.2813 (4.5); 7.1809 (4.8); 7.1604 (4.3); 4.3031 (4.8); 4.2882 (4.8); 4.0084 (1.5); 3.9866 (2.3); 3.9841 (2.6); 3.9624 (2.1); 3.8801 (2.2); 3.8647 (2.3); 3.8558 (1.6); 3.8404 (1.7); 3.3118 (41.0); 3.2854 (1.2); 3.2678 (0.9); 2.7637 (1.3); 2.7405 (1.1); 2.7215 (3.0); 2.6982 (2.8); 2.6747 (3.3); 2.6563 (2.9); 2.6326 (1.2); 2.6141 (1.2); 2.5228 (1.5); 2.5182 (2.1); 2.5095 (28.3); 2.5049 (61.7); 2.5003 (86.1); 2.4957 (60.2); 2.4911 (27.0); 2.2757 (16.0); -0.0002 (5.4) I.2-166:1H NMR (400.0 MHz, d6-DMSO): δ= 8.5395 (1.2); 7.5299 (4.3); 7.5084 (4.9); 7.2396 (4.6); 7.2207 (3.5); 7.2154 (2.8); 7.2082 (2.9); 7.1813 (3.7); 7.1609 (3.4); 4.2847 (3.7); 4.2704 (3.6); 4.0219 (1.2); 3.9979 (1.9); 3.9762 (1.6); 3.8806 (1.6); 3.8655 (1.7); 3.8563 (1.2); 3.8412 (1.2); 3.3287 (0.8); 3.3119 (44.2); 2.7763 (1.1); 2.7530 (1.0); 2.7342 (2.1); 2.7108 (2.0); 2.6662 (2.5); 2.6482 (2.0); 2.6241 (1.0); 2.6061 (1.1); 2.5095 (31.0); 2.5049 (65.5); 2.5003 (89.5); 2.4957 (62.7); 2.4912 (28.4); 2.3273 (0.5); 2.2755 (12.5); 2.2492 (16.0); -0.0002 (4.6) I.2-173:1H NMR (400.0MHz, d6-DMSO): δ= 8.5948 (0.5); 8.5812 (1.0); 8.5670 (0.5); 7.3452 (0.7); 7.3406 (0.8); 7.3194 (0.9); 7.3142 (0.8); 7.1915 (0.9); 7.1878 (1.0); 7.1790 (0.9); 7.1757 (1.1); 7.1711 (0.6); 7.1676 (0.7); 7.1587 (0.7); 7.1560 (0.8); 7.1433 (1.0); 7.1287 (1.2); 7.1255 (1.0); 7.1097 (0.5); 4.3616 (2.8); 4.3476 (2.9); 4.3009 (0.7); 4.2821 (1.0); 4.2627 (0.7); 3.5234 (1.2); 3.4999 (2.0); 3.4779 (1.6); 3.3445 (1.5); 3.3291 (1.7); 3.3207 (1.2); 3.3052 (1.3); 3.1411 (0.6); 3.1374 (0.6); 3.1257 (0.6); 3.1196 (0.9); 3.1153 (0.6); 3.1030 (0.6); 2.5106 (8.0); 2.5060 (18.0); 2.5014 (25.8); 2.4968 (18.6); 2.4922 (8.8); 2.4818 (1.3); 2.4585 (0.9); 2.4403 (2.6); 2.4170 (2.4); 2.4045 (2.6); 2.3858 (2.4); 2.3631 (0.9); 2.3444 (0.8); 2.0857 (16.0); 1.6807 (0.8); 1.6740 (1.0); 1.6566 (1.1); 1.6445 (1.6); 1.6353 (1.4); 1.6313 (1.4); 1.6264 (1.4); 1.6165 (0.9); 1.5357 (0.7); 1.5265 (1.1); 1.5171 (1.4); 1.5072 (2.0); 1.4920 (1.4); 1.4827 (1.1); 1.4706 (0.8); 1.4624 (0.6); -0.0002 (2.6) I.2-174:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4693 (0.5); 8.4557 (1.0); 8.4414 (0.5); 7.2354 (0.5); 7.2301 (0.6); 7.2162 (1.4); 7.2104 (4.6); 7.2042 (5.0); 7.2026 (5.7); 7.1817 (0.8); 4.2616 (1.7); 4.2498 (2.2); 4.2368 (1.7); 3.5437 (1.3); 3.5216 (2.2); 3.5197 (2.4); 3.4976 (3.2); 3.4791 (3.8); 3.3850 (1.6); 3.3704 (1.8); 3.3610 (1.2); 3.3463 (1.4); 3.1946 (0.5); 3.1899 (0.6); 3.1799 (0.5); 3.1727 (0.8); 3.1575 (0.6); 3.0298 (0.7); 3.0104 (0.8); 2.9967 (1.5); 2.9771 (1.6); 2.9430 (1.4); 2.9250 (1.5); 2.9097 (0.7); 2.8917 (0.7); 2.5234 (0.7); 2.5188 (1.0); 2.5101 (19.3); 2.5055 (42.6); 2.5009 (60.1); 2.4962 (42.1); 2.4916 (18.7); 2.4699 (2.0); 2.4466 (2.0); 2.4390 (2.1); 2.4211 (1.9); 2.3976 (0.7); 2.3797 (0.5); 2.2372 (16.0); 1.8551 (0.7); 1.8377 (0.9); 1.8200 (0.7); 0.8239 (9.1); 0.8070 (10.7); 0.8051 (11.2); 0.7883 (9.0); 0.0080 (0.7); -0.0002 (29.8); -0.0085 (0.9) I.2-175:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5627 (1.6); 8.5479 (3.0); 8.5337 (1.6); 7.3064 (5.6); 7.3009 (2.3); 7.2925 (6.4); 7.2843 (8.1); 7.2761 (2.8); 7.2704 (7.6); 7.2629 (0.8); 7.1794 (1.2); 7.1720 (10.2); 7.1665 (2.8); 7.1555 (3.0); 7.1496 (16.0); 7.1438 (3.0); 7.1328 (2.5); 7.1273 (7.3); 7.1198 (0.7); 4.4869 (0.7); 4.4667 (1.7); 4.4430 (3.4); 4.4231 (1.9); 4.3992 (0.8); 4.2738 (9.8); 4.2590 (9.7); 3.6510 (3.6); 3.6277 (6.3); 3.6051 (4.8); 3.4492 (4.6); 3.4331 (5.2); 3.4253 (3.8); 3.4093 (4.2); 3.3493 (29.5); 3.1617 (1.0); 3.1456 (1.3); 3.1395 (2.2); 3.1231 (2.3); 3.1197 (2.7); 3.1032 (2.3); 3.0972 (1.4); 3.0810 (1.0); 2.6744 (0.9); 2.6699 (1.3); 2.6653 (0.9); 2.5233 (4.0); 2.5186 (5.7); 2.5100 (74.4); 2.5054 (161.6); 2.5008 (225.3); 2.4961 (155.9); 2.4916 (68.6); 2.4622 (2.0); 2.4555 (1.4); 2.4507 (1.8); 2.4435 (9.4); 2.4284 (9.2); 2.4206 (8.8); 2.4085 (8.5); 2.3868 (1.8); 2.3669 (1.4); 2.3322 (1.2); 2.3276 (1.5); 2.3229 (1.1); 2.2239 (0.5); 2.1994 (1.7); 2.1949 (1.6); 2.1809 (2.2); 2.1751 (3.1); 2.1706 (3.2); 2.1637 (1.3); 2.1560 (2.9); 2.1517 (3.7); 2.1462 (3.0); 2.1320 (1.8); 2.1276 (2.7); 2.1031 (0.8); 2.0033 (1.4); 1.9926 (2.2); 1.9876 (2.4); 1.9805 (2.8); 1.9754 (3.1); 1.9687 (3.4); 1.9600 (3.2); 1.9488 (2.2); 1.9439 (2.0); 1.9328 (1.2); 1.6546 (1.2); 1.6484 (1.0); 1.6384 (3.5); 1.6295 (2.6); 1.6249 (3.4); 1.6140 (6.5); 1.6007 (3.7); 1.5894 (2.9); 1.5748 (1.1); 0.0080 (2.8); 0.0063 (1.0); 0.0055 (1.1); 0.0046 (1.3); -0.0002 (90.0); -0.0052 (1.2); -0.0060 (0.9); -0.0068 (0.8); - 0.0085 (2.6) I.2-176:1H NMR (400.0MHz, d6-DMSO): δ= 8.5589 (1.6); 8.5446 (3.0); 8.5302 (1.6); 7.3547 (0.6); 7.3500 (2.5); 7.3475 (4.8); 7.3440 (1.6); 7.3356 (2.7); 7.3338 (2.4); 7.3289 (8.3); 7.3264 (10.1); 7.3185 (2.2); 7.3110 (11.8); 7.3064 (2.2); 7.2621 (14.4); 7.2607 (16.0); 7.2532 (3.2); 7.2492 (2.5); 7.2438 (11.0); 7.2399 (6.3); 7.2381 (5.8); 7.2329 (0.9); 7.2298 (1.4); 7.2261 (2.0); 7.2226 (0.9); 4.4902 (0.7); 4.4703 (1.8); 4.4666 (1.8); 4.4466 (3.5); 4.4266 (2.0); 4.4226 (1.9); 4.4027 (0.9); 4.2970 (10.9); 4.2822 (10.8); 4.2586 (0.6); 4.2436 (0.7); 4.2321 (0.6); 4.1315 (1.0); 3.6588 (3.8); 3.6353 (6.5); 3.6129 (5.1); 3.4603 (4.7); 3.4442 (5.2); 3.4364 (3.8); 3.4204 (4.2); 3.1753 (1.0); 3.1592 (1.3); 3.1533 (2.4); 3.1389 (2.2); 3.1369 (2.5); 3.1331 (2.9); 3.1168 (2.5); 3.1108 (1.4); 3.0947 (1.0); 2.5233 (0.7); 2.5186 (1.2); 2.5099 (18.7); 2.5053 (41.2); 2.5007 (57.6); 2.4961 (40.3); 2.4915 (19.1); 2.4685 (1.3); 2.4496 (9.6); 2.4381 (9.3); 2.4269 (9.0); 2.4180 (8.9); 2.3964 (1.5); 2.3764 (1.1); 2.2277 (0.5); 2.2102 (0.8); 2.2031 (1.6); 2.1987 (1.5); 2.1925 (0.8); 2.1854 (2.2); 2.1813 (2.4); 2.1785 (2.8); 2.1743 (3.2); 2.1679 (1.4); 2.1610 (2.9); 2.1570 (3.4); 2.1545 (2.7); 2.1500 (3.0); 2.1434 (1.1); 2.1370 (1.8); 2.1327 (2.6); 2.1257 (1.2); 2.1082 (0.8); 2.0054 (1.3); 1.9947 (2.2); 1.9891 (2.2); 1.9864 (2.2); 1.9823 (2.6); 1.9765 (3.4); 1.9710 (3.5); 1.9652 (3.1); 1.9615 (3.2); 1.9571 (2.7); 1.9511 (2.3); 1.9461 (2.0); 1.9415 (1.4); 1.9351 (1.0); 1.6554 (1.2); 1.6481 (0.9); 1.6393 (3.6); 1.6303 (2.7); 1.6261 (3.5); 1.6150 (6.6); 1.6017 (3.6); 1.5904 (3.0); 1.5788 (0.9); 1.5756 (1.0); -0.0002 (5.8) I.2-177:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4635 (0.5); 7.1850 (2.0); 7.1797 (0.6); 7.1685 (0.7); 7.1631 (2.3); 6.8958 (2.9); 6.8904 (0.8); 6.8792 (0.8); 6.8739 (2.5); 4.4424 (0.6); 4.2182 (1.9); 4.2036 (1.9); 3.7275 (16.0); 3.6413 (0.6); 3.6181 (1.0); 3.5955 (0.8); 3.4417 (0.7); 3.4256 (0.8); 3.4179 (0.6); 3.4018 (0.6); 2.5101 (2.8); 2.5055 (6.2); 2.5008 (8.6); 2.4962 (6.0); 2.4916 (2.6); 2.4318 (1.5); 2.4219 (1.5); 2.4092 (1.4); 2.4017 (1.4); 2.1529 (0.6); 1.9734 (0.6); 1.9692 (0.5); 1.9581 (0.5); 1.6373 (0.6); 1.6239 (0.5); 1.6129 (1.0); 1.5995 (0.6); -0.0002 (1.0) I.2-178:1H NMR (400.0MHz, d6-DMSO): δ= 8.5905 (1.3); 8.5758 (2.6); 8.5611 (1.3); 7.4038 (1.2); 7.3974 (10.8); 7.3924 (3.6); 7.3812 (4.4); 7.3760 (16.0); 7.3698 (1.9); 7.2901 (1.7); 7.2840 (12.3); 7.2787 (3.4); 7.2675 (3.0); 7.2624 (8.3); 7.2562 (0.8); 4.4878 (0.5); 4.4679 (1.4); 4.4644 (1.4); 4.4441 (2.7); 4.4241 (1.5); 4.4201 (1.4); 4.4004 (0.6); 4.2803 (8.6); 4.2655 (8.5); 3.6543 (4.7); 3.6311 (7.0); 3.6085 (4.8); 3.4516 (3.7); 3.4356 (4.0); 3.4277 (3.0); 3.4117 (3.2); 3.1695 (0.8); 3.1533 (1.0); 3.1494 (1.6); 3.1473 (1.7); 3.1335 (1.6); 3.1307 (1.8); 3.1276 (2.2); 3.1112 (1.8); 3.1050 (1.1); 3.0889 (0.8); 2.5240 (0.7); 2.5194 (1.0); 2.5107 (13.8); 2.5061 (30.2); 2.5014 (42.1); 2.4968 (29.4); 2.4922 (13.3); 2.4672 (1.2); 2.4485 (7.0); 2.4308 (7.1); 2.4256 (6.6); 2.4111 (6.4); 2.3891 (1.5); 2.3694 (1.2); 2.2002 (1.3); 2.1961 (1.2); 2.1886 (0.6); 2.1805 (1.7); 2.1759 (2.5); 2.1716 (2.4); 2.1643 (1.0); 2.1564 (2.2); 2.1524 (3.0); 2.1474 (2.3); 2.1401 (0.8); 2.1323 (1.4); 2.1282 (2.1); 2.1037 (0.6); 2.0035 (1.0); 1.9925 (1.8); 1.9883 (1.8); 1.9805 (2.2); 1.9766 (2.6); 1.9721 (2.3); 1.9686 (2.6); 1.9644 (2.2); 1.9606 (2.5); 1.9573 (2.4); 1.9522 (1.6); 1.9486 (1.7); 1.9446 (1.6); 1.9327 (1.0); 1.9291 (0.7); 1.6551 (0.9); 1.6477 (0.7); 1.6389 (2.8); 1.6300 (2.1); 1.6256 (2.6); 1.6146 (5.1); 1.6012 (2.8); 1.5899 (2.3); 1.5753 (0.8); -0.0002 (4.7) I.2-179:1H NMR (400.0MHz, d6-DMSO): δ= 8.5694 (1.4); 8.5553 (2.7); 8.5414 (1.4); 7.4597 (2.8); 7.4568 (5.0); 7.4536 (2.6); 7.4412 (3.7); 7.4389 (7.0); 7.4357 (3.9); 7.3465 (3.4); 7.3428 (7.5); 7.3410 (4.3); 7.3328 (16.0); 7.3301 (13.6); 7.3224 (6.4); 7.3117 (3.1); 7.3096 (1.7); 7.3039 (3.3); 7.2989 (1.2); 7.2929 (2.9); 7.2809 (1.1); 4.4916 (0.6); 4.4720 (1.4); 4.4482 (2.8); 4.4283 (1.5); 4.4243 (1.5); 4.4042 (0.8); 4.3638 (10.2); 4.3493 (10.1); 3.6733 (3.1); 3.6499 (5.3); 3.6275 (4.2); 3.5015 (3.6); 3.4738 (5.4); 3.4579 (5.0); 3.4499 (3.7); 3.4340 (3.8); 3.2194 (0.9); 3.2036 (1.0); 3.1974 (1.7); 3.1839 (1.6); 3.1809 (1.9); 3.1779 (2.2); 3.1616 (1.8); 3.1553 (1.2); 3.1393 (0.8); 2.6744 (0.6); 2.6699 (0.9); 2.6652 (0.6); 2.5234 (1.9); 2.5187 (2.7); 2.5100 (45.9); 2.5054 (102.4); 2.5007 (143.4); 2.4961 (99.2); 2.4915 (43.7); 2.4845 (2.9); 2.4656 (7.6); 2.4557 (1.1); 2.4468 (8.1); 2.4426 (7.4); 2.4273 (6.9); 2.4052 (1.7); 2.3856 (1.3); 2.3322 (0.6); 2.3276 (0.9); 2.3230 (0.7); 2.2073 (1.4); 2.2032 (1.2); 2.1826 (3.0); 2.1789 (2.7); 2.1717 (1.0); 2.1618 (2.4); 2.1583 (3.5); 2.1545 (2.7); 2.1377 (1.4); 2.1339 (2.4); 2.1094 (0.7); 2.0060 (1.0); 1.9950 (2.0); 1.9906 (1.8); 1.9802 (2.8); 1.9750 (2.9); 1.9711 (2.3); 1.9677 (2.1); 1.9647 (2.5); 1.9606 (2.8); 1.9558 (1.8); 1.9504 (1.8); 1.9476 (1.6); 1.9358 (0.9); 1.6578 (1.0); 1.6526 (0.7); 1.6420 (2.9); 1.6327 (2.3); 1.6290 (2.9); 1.6177 (5.3); 1.6044 (2.8); 1.5931 (2.5); 1.5782 (0.9); 0.0080 (1.7); -0.0002 (61.3); -0.0052 (0.6); -0.0085 (1.7) I.2-180:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5511 (0.8); 8.5366 (1.5); 8.5221 (0.8); 7.3014 (3.0); 7.2959 (1.2); 7.2875 (3.1); 7.2793 (4.4); 7.2711 (1.4); 7.2654 (3.7); 7.2578 (0.5); 7.1740 (0.6); 7.1667 (4.9); 7.1611 (1.3); 7.1501 (1.5); 7.1442 (7.7); 7.1384 (1.5); 7.1274 (1.2); 7.1220 (3.6); 4.2699 (4.2); 4.2551 (4.1); 4.0348 (0.7); 3.5247 (1.8); 3.5025 (2.8); 3.5008 (3.1); 3.4787 (2.6); 3.3816 (2.4); 3.3666 (2.7); 3.3574 (1.8); 3.3425 (2.1); 3.3236 (40.5); 3.1784 (0.5); 3.1634 (0.6); 3.1596 (0.9); 3.1562 (1.0); 3.1446 (0.9); 3.1409 (1.1); 3.1376 (1.3); 3.1341 (0.8); 3.1223 (1.1); 3.1191 (0.7); 3.1151 (0.6); 3.0197 (1.0); 3.0003 (1.0); 2.9865 (2.5); 2.9670 (2.6); 2.9474 (2.4); 2.9293 (2.5); 2.9141 (1.0); 2.8960 (1.0); 2.5194 (0.5); 2.5107 (7.7); 2.5061 (17.0); 2.5015 (24.0); 2.4969 (16.7); 2.4923 (7.4); 2.4770 (0.6); 2.4582 (3.2); 2.4517 (0.5); 2.4417 (3.5); 2.4355 (3.2); 2.4229 (3.2); 2.4002 (0.6); 2.3814 (0.5); 1.8688 (0.6); 1.8511 (1.1); 1.8341 (1.4); 1.8170 (1.1); 1.7989 (0.6); 0.8219 (14.1); 0.8084 (16.0); 0.8053 (15.6); 0.7918 (13.8); -0.0002 (2.8) I.2-181:1H NMR (400.0MHz, d6-DMSO): δ= 8.5982 (2.4); 8.5838 (4.7); 8.5695 (2.4); 7.6185 (15.5); 7.6133 (16.0); 7.4450 (7.3); 7.4396 (6.6); 7.4242 (11.4); 7.4188 (11.0); 7.3573 (13.6); 7.3364 (8.5); 4.4885 (0.9); 4.4689 (2.3); 4.4653 (2.2); 4.4451 (4.4); 4.4251 (2.5); 4.4213 (2.4); 4.4014 (1.0); 4.3339 (14.7); 4.3196 (14.5); 3.6656 (4.8); 3.6421 (8.2); 3.6197 (6.4); 3.4628 (20.1); 3.4473 (14.3); 3.4391 (8.6); 3.4232 (6.8); 3.2100 (1.4); 3.1939 (1.7); 3.1905 (2.4); 3.1877 (2.6); 3.1746 (2.4); 3.1710 (3.0); 3.1686 (3.4); 3.1521 (2.7); 3.1457 (1.8); 3.1297 (1.2); 2.6750 (0.7); 2.6703 (1.0); 2.6658 (0.7); 2.5239 (2.4); 2.5192 (3.4); 2.5105 (50.4); 2.5059 (111.8); 2.5013 (155.8); 2.4966 (108.2); 2.4920 (47.2); 2.4807 (3.2); 2.4621 (11.2); 2.4561 (1.6); 2.4514 (1.8); 2.4466 (1.7); 2.4383 (17.8); 2.4185 (10.3); 2.3962 (2.9); 2.3768 (2.5); 2.3327 (0.7); 2.3281 (1.0); 2.3234 (0.7); 2.2276 (0.7); 2.2027 (2.3); 2.1991 (2.0); 2.1887 (1.4); 2.1781 (4.8); 2.1746 (4.2); 2.1646 (1.6); 2.1568 (3.9); 2.1535 (5.6); 2.1501 (4.4); 2.1431 (1.4); 2.1325 (2.3); 2.1290 (3.7); 2.1045 (1.0); 2.0856 (2.9); 2.0049 (1.4); 1.9928 (3.2); 1.9886 (2.8); 1.9795 (4.1); 1.9738 (4.5); 1.9675 (3.5); 1.9631 (3.8); 1.9598 (4.1); 1.9546 (2.7); 1.9483 (3.0); 1.9347 (1.3); 1.6572 (1.6); 1.6518 (1.2); 1.6411 (4.5); 1.6320 (3.5); 1.6279 (4.5); 1.6168 (8.3); 1.6034 (4.6); 1.5922 (3.8); 1.5774 (1.3); -0.0002 (17.0) I.2-182:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4837 (0.6); 8.4697 (1.1); 8.4562 (0.6); 7.2339 (0.8); 7.2145 (7.1); 7.2070 (3.5); 7.2056 (3.2); 7.1863 (0.6); 4.4657 (0.6); 4.4451 (1.1); 4.4255 (0.6); 4.2630 (2.2); 4.2586 (2.1); 4.2488 (2.2); 4.2443 (2.1); 3.6694 (1.2); 3.6461 (2.0); 3.6237 (1.6); 3.4568 (1.5); 3.4412 (1.6); 3.4327 (1.1); 3.4172 (1.3); 3.3201 (159.6); 3.2704 (1.1); 3.1744 (0.6); 3.1624 (0.6); 3.1563 (0.8); 3.1399 (0.6); 2.6700 (0.5); 2.5235 (1.3); 2.5188 (1.9); 2.5101 (29.1); 2.5055 (63.8); 2.5009 (89.5); 2.4963 (62.3); 2.4917 (27.5); 2.4765 (1.1); 2.4581 (2.9); 2.4514 (0.8); 2.4468 (0.6); 2.4348 (2.4); 2.4257 (2.5); 2.4067 (2.4); 2.3841 (0.8); 2.3651 (0.7); 2.3277 (0.6); 2.2412 (16.0); 2.2042 (0.6); 2.1995 (0.5); 2.1793 (1.2); 2.1754 (1.2); 2.1552 (1.2); 2.1512 (1.6); 2.1311 (0.6); 2.1269 (1.0); 1.9964 (0.7); 1.9843 (0.9); 1.9793 (1.0); 1.9731 (1.1); 1.9672 (1.0); 1.9640 (1.0); 1.9529 (0.7); 1.9481 (0.7); 1.6411 (1.1); 1.6279 (1.1); 1.6167 (2.1); 1.6033 (1.2); 1.5921 (1.0); -0.0002 (1.8) I.3-1:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.2398 (5.1); 8.5853 (1.3); 8.1448 (5.0); 8.1417 (5.3); 8.0266 (2.0); 8.0181 (2.2); 8.0111 (3.3); 8.0064 (2.0); 8.0028 (2.2); 7.9969 (2.0); 7.6993 (1.5); 7.6781 (1.9); 7.6664 (7.3); 7.6605 (7.4); 7.6103 (10.0); 7.6081 (9.9); 7.6020 (4.7); 7.5986 (4.7); 7.5948 (5.4); 7.5749 (0.8); 7.4210 (4.5); 7.4149 (4.2); 7.3993 (3.8); 7.3933 (3.6); 4.9844 (1.0); 4.2768 (2.4); 4.2596 (2.6); 4.2506 (3.0); 4.2336 (2.4); 4.0559 (1.2); 4.0381 (3.5); 4.0204 (3.5); 4.0025 (1.2); 3.8234 (1.8); 3.8151 (1.9); 3.7968 (1.6); 3.7893 (1.7); 3.3652 (0.6); 3.3083 (239.8); 3.2782 (1.0); 3.2631 (0.7); 3.2571 (1.0); 3.0835 (2.4); 3.0629 (2.7); 3.0401 (3.0); 3.0195 (2.7); 2.6738 (1.9); 2.6694 (2.7); 2.6649 (1.9); 2.6000 (2.2); 2.5920 (2.5); 2.5227 (16.1); 2.5179 (21.3); 2.5094 (159.3); 2.5049 (328.5); 2.5003 (452.2); 2.4957 (325.7); 2.4912 (153.7); 2.3939 (0.8); 2.3317 (2.2); 2.3271 (2.8); 2.3227 (2.2); 2.0723 (0.6); 1.9877 (16.0); 1.2459 (1.5); 1.1923 (4.3); 1.1745 (8.5); 1.1567 (4.2); 0.8752 (0.8); 0.8583 (2.2); 0.8406 (0.8); -0.0002 (13.6) I.3-2:1H NMR (400.0MHz, d6-DMSO): δ= 8.7226 (1.7); 8.7072 (1.6); 7.6936 (4.6); 7.6878 (1.6); 7.6813 (5.1); 7.6759 (2.5); 7.6704 (5.3); 7.6639 (1.8); 7.6581 (5.2); 7.4779 (5.2); 7.4715 (5.7); 7.4582 (5.4); 7.4368 (8.4); 7.3655 (4.6); 7.3590 (4.0); 7.3441 (2.9); 7.3376 (2.6); 7.2416 (5.2); 7.2357 (1.4); 7.2197 (7.1); 7.2026 (1.4); 7.1969 (4.6); 4.4172 (1.1); 4.1515 (2.3); 4.1346 (2.4); 4.1259 (2.9); 4.1093 (2.2); 3.6352 (2.2); 3.6275 (2.3); 3.6105 (16.0); 3.6023 (2.7); 3.3447 (0.6); 3.3128 (133.3); 3.3104 (175.4); 2.9460 (2.1); 2.9257 (2.4); 2.9032 (2.7); 2.8830 (2.4); 2.6741 (2.1); 2.6695 (2.8); 2.6648 (2.0); 2.5505 (0.9); 2.5230 (6.9); 2.5182 (10.4); 2.5096 (156.4); 2.5050 (344.5); 2.5004 (484.3); 2.4957 (340.7); 2.4912 (153.8); 2.4250 (2.3); 2.4160 (2.5); 2.3821 (2.0); 2.3734 (2.1); 2.3319 (2.1); 2.3272 (2.9); 2.3225 (2.1); 2.0726 (0.8); 0.0080 (1.8); -0.0002 (66.3); -0.0086 (1.8) I.3-3:1H NMR (400.0MHz, d6-DMSO): δ= 8.7233 (2.0); 8.7066 (1.9); 7.5361 (0.6); 7.5296 (0.7); 7.5031 (0.9); 7.4910 (4.1); 7.4853 (4.7); 7.4756 (6.5); 7.4691 (8.6); 7.4608 (9.6); 7.4541 (1.6); 7.4485 (1.0); 7.4396 (9.9); 7.4281 (0.6); 7.3900 (0.5); 7.3835 (0.5); 7.3667 (5.2); 7.3602 (4.6); 7.3453 (3.3); 7.3388 (3.0); 7.0378 (0.8); 7.0320 (1.3); 7.0264 (0.8); 7.0149 (1.7); 7.0091 (2.7); 7.0033 (1.3); 6.9914 (1.0); 6.9860 (1.4); 5.7539 (1.0); 4.4504 (0.5); 4.4424 (0.8); 4.4334 (1.2); 4.4231 (1.1); 4.4152 (1.2); 4.4065 (0.9); 4.3979 (0.6); 4.1424 (2.3); 4.1256 (2.5); 4.1162 (3.0); 4.0994 (2.3); 3.7247 (2.0); 3.6659 (2.3); 3.6587 (2.2); 3.6398 (2.1); 3.6326 (2.1); 3.6048 (16.0); 3.3125 (42.0); 3.0086 (2.4); 2.9883 (2.6); 2.9654 (3.0); 2.9452 (2.6); 2.6744 (0.9); 2.6698 (1.2); 2.6651 (0.9); 2.5232 (3.9); 2.5185 (5.7); 2.5098 (73.6); 2.5053 (158.5); 2.5006 (221.2); 2.4960 (154.1); 2.4914 (68.4); 2.4631 (2.7); 2.4546 (2.8); 2.4199 (2.1); 2.4115 (2.1); 2.3321 (1.0); 2.3275 (1.3); 2.3228 (0.9); -0.0002 (7.0) I.3-5:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.7291 (2.1); 8.7132 (2.1); 7.8955 (4.5); 7.8897 (1.9); 7.8785 (3.0); 7.8726 (15.0); 7.8532 (14.5); 7.8473 (2.9); 7.8360 (1.7); 7.8303 (4.2); 7.4737 (5.8); 7.4673 (6.3); 7.4557 (5.9); 7.4343 (9.1); 7.3638 (4.7); 7.3572 (4.4); 7.3424 (3.1); 7.3358 (3.0); 5.7522 (5.5); 4.4386 (1.2); 4.1940 (2.3); 4.1771 (2.3); 4.1679 (2.8); 4.1514 (2.4); 4.0380 (0.5); 4.0205 (0.6); 3.7054 (2.2); 3.6980 (2.2); 3.6790 (2.0); 3.6720 (1.9); 3.6040 (16.0); 3.3057 (50.4); 3.0175 (2.3); 2.9972 (2.5); 2.9742 (2.9); 2.9542 (2.6); 2.6737 (1.4); 2.6692 (2.0); 2.6645 (1.3); 2.5226 (5.3); 2.5178 (7.7); 2.5092 (117.0); 2.5047 (250.0); 2.5001 (344.6); 2.4955 (241.8); 2.4910 (109.1); 2.4743 (2.9); 2.4399 (2.3); 2.4308 (2.0); 2.3317 (1.5); 2.3269 (2.0); 2.0101 (0.6); 1.9876 (2.3); 1.3457 (0.6); 1.3342 (0.8); 1.2392 (0.5); 1.1924 (0.6); 1.1746 (1.2); 1.1568 (0.6); 0.8882 (0.6); 0.8714 (0.7); 0.1460 (0.7); 0.0080 (5.0); -0.0002 (171.6); -0.0085 (5.3); -0.1494 (0.6) I.3-6:1H NMR (400.0MHz, d6-DMSO): δ= 8.7226 (1.5); 8.7061 (1.5); 7.5379 (6.0); 7.5331 (1.9); 7.5214 (2.1); 7.5166 (6.7); 7.4888 (0.5); 7.4788 (4.1); 7.4723 (4.6); 7.4581 (4.4); 7.4367 (6.8); 7.3657 (3.9); 7.3592 (3.4); 7.3443 (2.4); 7.3378 (2.2); 7.1893 (4.7); 7.1689 (4.2); 5.7549 (0.6); 4.4242 (0.7); 4.4154 (0.8); 4.4073 (0.8); 4.3958 (0.8); 4.3872 (0.7); 4.1268 (1.8); 4.1101 (2.0); 4.1012 (2.3); 4.0845 (1.7); 3.7234 (0.7); 3.6190 (2.2); 3.6105 (12.5); 3.5935 (1.6); 3.5861 (1.5); 3.3694 (1.4); 3.3543 (0.6); 3.3517 (0.8); 3.3197 (533.8); 3.2703 (4.1); 2.9331 (1.7); 2.9128 (2.0); 2.8904 (2.1); 2.8700 (1.9); 2.6746 (1.0); 2.6701 (1.5); 2.6654 (1.1); 2.5341 (0.6); 2.5236 (3.5); 2.5189 (5.0); 2.5102 (79.8); 2.5056 (177.0); 2.5010 (249.4); 2.4963 (173.3); 2.4917 (76.1); 2.4604 (1.1); 2.4559 (1.9); 2.4512 (2.6); 2.4466 (1.9); 2.4128 (1.9); 2.4037 (2.0); 2.3702 (1.6); 2.3611 (1.6); 2.3324 (1.2); 2.3278 (1.7); 2.3231 (1.1); 2.2790 (16.0); 2.0731 (1.4); -0.0002 (2.3) I.3-7:1H NMR (400.0MHz, d6-DMSO): δ= 8.7216 (0.9); 8.7053 (0.9); 7.5552 (3.4); 7.5496 (1.1); 7.5379 (1.2); 7.5324 (3.6); 7.4811 (2.1); 7.4747 (2.3); 7.4598 (2.0); 7.4384 (3.0); 7.3669 (1.6); 7.3605 (1.4); 7.3455 (1.0); 7.3390 (0.9); 6.9537 (3.7); 6.9481 (1.0); 6.9363 (1.1); 6.9309 (3.3); 4.1174 (0.9); 4.1006 (0.9); 4.0919 (1.1); 4.0752 (0.8); 3.7425 (16.0); 3.6139 (5.9); 3.6014 (1.0); 3.5936 (0.9); 3.5756 (0.8); 3.5682 (0.8); 3.3183 (33.3); 2.9147 (0.8); 2.8944 (0.9); 2.8722 (1.0); 2.8518 (0.9); 2.5234 (1.5); 2.5101 (14.9); 2.5056 (29.8); 2.5011 (39.8); 2.4966 (28.0); 2.4921 (13.0); 2.3980 (1.0); 2.3890 (0.9); 2.3555 (0.8); 2.3464 (0.8); 0.0080 (0.6); -0.0002 (15.0); -0.0084 (0.6) I.3-8:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.7062 (2.0); 8.6897 (2.0); 7.7218 (0.9); 7.7137 (9.0); 7.7083 (2.7); 7.6966 (2.9); 7.6910 (10.8); 7.6830 (1.1); 7.4538 (1.2); 7.4458 (11.4); 7.4403 (3.0); 7.4286 (2.9); 7.4232 (9.6); 7.4174 (2.9); 7.4109 (1.5); 7.4058 (2.6); 7.4019 (2.2); 7.3943 (3.6); 7.3855 (0.5); 7.3652 (1.9); 7.3577 (1.6); 7.3540 (2.6); 7.3482 (1.6); 7.3420 (3.2); 7.2948 (1.2); 7.2905 (0.8); 7.2834 (6.7); 7.2823 (6.3); 7.2764 (3.9); 7.2720 (4.2); 7.2702 (4.4); 7.2659 (3.1); 7.2595 (5.1); 7.2475 (0.6); 4.4429 (0.8); 4.4338 (1.0); 4.4263 (1.0); 4.4230 (1.0); 4.4151 (1.0); 4.4064 (0.8); 4.1509 (2.2); 4.1340 (2.3); 4.1252 (2.7); 4.1085 (2.1); 3.6492 (2.0); 3.6416 (2.0); 3.6236 (1.9); 3.6161 (1.9); 3.5883 (16.0); 3.3209 (108.5); 3.2705 (1.0); 2.9626 (2.2); 2.9423 (2.3); 2.9197 (2.7); 2.8994 (2.4); 2.5237 (1.0); 2.5190 (1.5); 2.5102 (20.8); 2.5057 (45.7); 2.5011 (64.0); 2.4965 (45.0); 2.4919 (20.3); 2.4600 (0.5); 2.4554 (0.7); 2.4508 (1.0); 2.4458 (2.7); 2.4366 (2.3); 2.4028 (2.0); 2.3938 (2.0); -0.0002 (4.4) I.3-9:1H NMR (400.0MHz, d6-DMSO): δ= 8.7283 (2.2); 8.7122 (2.1); 7.7201 (1.1); 7.7120 (10.2); 7.7064 (3.1); 7.6948 (3.3); 7.6892 (12.3); 7.6812 (1.1); 7.4769 (5.7); 7.4706 (6.0); 7.4583 (6.3); 7.4537 (1.4); 7.4458 (13.0); 7.4401 (3.9); 7.4370 (9.7); 7.4285 (3.0); 7.4230 (10.5); 7.4150 (0.8); 7.3660 (5.2); 7.3595 (4.6); 7.3446 (3.3); 7.3381 (3.0); 4.4280 (1.0); 4.4199 (1.0); 4.4084 (1.0); 4.3998 (0.8); 4.1497 (2.3); 4.1329 (2.5); 4.1240 (2.9); 4.1073 (2.1); 3.6427 (2.2); 3.6354 (2.1); 3.6166 (2.6); 3.6078 (16.0); 3.3682 (0.8); 3.3510 (0.7); 3.3184 (408.3); 3.2683 (3.6); 2.9644 (2.4); 2.9441 (2.5); 2.9215 (2.9); 2.9012 (2.5); 2.6748 (1.0); 2.6700 (1.5); 2.6654 (1.0); 2.5236 (3.5); 2.5189 (5.0); 2.5102 (75.1); 2.5056 (166.7); 2.5010 (234.6); 2.4963 (162.9); 2.4917 (71.5); 2.4604 (1.1); 2.4556 (1.8); 2.4510 (2.4); 2.4464 (1.9); 2.4374 (2.7); 2.4285 (2.4); 2.3945 (2.1); 2.3856 (2.0); 2.3325 (1.1); 2.3278 (1.5); 2.3231 (1.0); 2.0735 (1.0); 1.9884 (2.1); 1.1923 (0.6); 1.1745 (1.4); 1.1566 (0.7); 0.0081 (1.5); 0.0041 (0.6); 0.0024 (1.6); -0.0002 (53.7); -0.0085 (1.6); -0.0502 (0.6) I.3-10:1H NMR (400.0MHz, d6-DMSO): δ= 7.7826 (0.6); 7.7758 (0.7); 7.5032 (1.5); 7.4688 (5.6); 7.4626 (6.1); 7.4576 (6.3); 7.4363 (7.9); 7.4199 (0.6); 7.4054 (0.7); 7.3573 (4.5); 7.3507 (3.8); 7.3358 (3.1); 7.3293 (3.1); 7.3084 (0.7); 7.2734 (0.6); 7.2542 (2.0); 7.2361 (0.5); 7.0150 (1.6); 5.7538 (2.1); 4.5594 (1.1); 4.0380 (1.3); 4.0202 (1.2); 3.5680 (16.0); 3.3107 (324.8); 3.2608 (1.9); 3.1912 (0.6); 2.6741 (1.9); 2.6695 (2.7); 2.6648 (1.9); 2.5230 (6.7); 2.5183 (9.7); 2.5096 (147.3); 2.5050 (326.1); 2.5004 (460.0); 2.4957 (319.1); 2.4911 (140.6); 2.4595 (2.2); 2.4550 (3.2); 2.4504 (3.9); 2.4459 (2.7); 2.4007 (0.7); 2.3806 (1.0); 2.3319 (2.1); 2.3272 (2.9); 2.3225 (2.0); 2.0725 (0.8); 1.9878 (5.3); 1.2354 (1.0); 1.1923 (2.0); 1.1745 (3.6); 1.1567 (1.9); 0.1459 (0.8); 0.0080 (7.6); 0.0064 (1.2); 0.0055 (1.3); 0.0047 (1.7); 0.0038 (2.8); 0.0022 (9.2); -0.0002 (295.3); -0.0043 (6.6); -0.0052 (4.9); -0.0060 (4.1); -0.0068 (3.6); -0.0085 (9.4); -0.0107 (2.2); -0.0115 (1.9); - 0.0123 (1.7); -0.0132 (1.5); -0.0140 (1.4); -0.0148 (1.4); -0.0163 (1.2); -0.0171 (1.2); -0.0187 (1.0); - 0.0219 (0.9); -0.0322 (0.6); -0.0502 (1.9); -0.1200 (0.6); -0.1498 (0.9) I.3-11:1H NMR (400.0 MHz, i.e6-DMSO): δ= 16.1969 (1.7); 7.8949 (1.9); 7.5380 (4.4); 7.5344 (6.1); 7.5205 (5.2); 7.5186 (5.4); 7.5160 (6.7); 7.4871 (3.5); 7.4809 (3.5); 7.4700 (3.8); 7.4641 (5.0); 7.4570 (4.3); 7.4236 (3.7); 7.4097 (5.2); 7.4007 (5.0); 7.3854 (6.2); 7.3797 (6.5); 7.3668 (8.6); 7.3604 (7.8); 7.3577 (7.4); 7.3537 (5.1); 7.3483 (16.0); 7.3442 (9.3); 7.3397 (6.5); 7.3358 (8.7); 7.3305 (10.9); 7.3270 (11.5); 7.3225 (6.6); 7.3095 (6.0); 7.2986 (10.3); 7.2933 (10.4); 7.2896 (7.7); 7.2830 (9.2); 7.2756 (12.0); 7.2709 (5.4); 7.2627 (5.1); 7.2574 (9.6); 7.2528 (7.0); 7.2440 (5.8); 7.2401 (7.0); 7.2376 (6.5); 7.2344 (3.7); 7.2254 (4.7); 7.2200 (3.6); 7.2070 (1.8); 5.3133 (7.8); 4.1001 (3.0); 4.0566 (6.5); 4.0037 (6.4); 3.9598 (2.6); 3.7650 (13.2); 3.4143 (2.1); 3.4036 (4.3); 3.3954 (4.5); 3.3781 (4.9); 3.3669 (11.2); 3.3501 (3.2); 3.3459 (4.1); 3.3406 (17.1); 3.3128 (2813.9); 3.2941 (8.0); 3.2807 (4.9); 3.2783 (9.4); 3.2634 (15.8); 3.2220 (2.2); 3.2133 (2.5); 3.1936 (5.0); 2.6742 (8.2); 2.6695 (10.9); 2.6649 (7.7); 2.5231 (32.0); 2.5184 (45.3); 2.5097 (606.0); 2.5051 (1326.1); 2.5005 (1862.2); 2.4959 (1286.0); 2.4913 (559.9); 2.4656 (4.5); 2.4601 (6.9); 2.4552 (9.9); 2.4507 (11.9); 2.4461 (8.3); 2.4048 (2.8); 2.3320 (8.0); 2.3273 (11.8); 2.3226 (7.6); 2.0722 (2.2); 1.2361 (1.7); 1.1744 (5.2); 1.1566 (10.6); 1.1388 (4.7); 1.0458 (4.9); 1.0283 (10.2); 1.0106 (4.4); -0.0002 (37.3) I.3-12:1H NMR (400.0MHz, d6-DMSO): δ= 9.2219 (6.0); 8.7998 (3.0); 8.7831 (3.1); 7.9455 (2.4); 7.6726 (11.5); 7.6698 (14.3); 7.6506 (16.0); 7.6481 (13.5); 7.6242 (4.5); 7.6212 (5.2); 7.6021 (5.8); 7.5995 (5.1); 7.5333 (11.0); 7.5117 (13.1); 7.4156 (4.8); 7.4074 (11.7); 7.4023 (4.5); 7.3972 (6.3); 7.3942 (5.9); 7.3889 (15.5); 7.3754 (4.8); 7.3721 (4.2); 7.3672 (11.9); 7.2928 (3.9); 7.2777 (3.3); 7.1904 (2.3); 7.1679 (6.8); 7.1494 (10.1); 7.1309 (4.5); 4.9216 (1.9); 4.8666 (1.7); 4.2616 (4.6); 4.2454 (5.4); 4.2356 (6.1); 4.2269 (2.8); 4.2195 (5.0); 4.2118 (2.3); 4.2004 (2.7); 4.1851 (2.6); 4.0002 (1.8); 3.9717 (1.4); 3.7942 (3.6); 3.7751 (3.3); 3.3090 (478.0); 3.2581 (2.1); 3.1898 (1.4); 3.0822 (2.3); 3.0642 (4.8); 3.0455 (4.2); 3.0395 (3.4); 3.0219 (6.6); 3.0027 (4.3); 2.7615 (1.7); 2.7536 (1.5); 2.6740 (5.4); 2.6695 (7.6); 2.6648 (5.6); 2.5634 (2.7); 2.5228 (21.4); 2.5182 (29.7); 2.5095 (441.1); 2.5049 (976.2); 2.5003 (1372.0); 2.4957 (956.4); 2.4911 (431.7); 2.4542 (2.7); 2.4496 (3.8); 2.4453 (3.7); 2.3318 (6.1); 2.3271 (8.6); 2.3225 (6.2); 1.9878 (1.8); 0.0080 (5.9); -0.0002 (224.2); -0.0085 (6.7) I.3-15:1H NMR (400.0MHz, d6-DMSO): δ= 8.6226 (0.9); 8.6066 (0.9); 7.4931 (2.0); 7.4874 (2.2); 7.4676 (2.3); 7.4620 (1.8); 7.1686 (0.9); 7.1542 (1.8); 7.1479 (1.7); 7.1341 (1.4); 7.1289 (2.5); 7.1258 (2.4); 7.1180 (4.3); 7.1122 (3.2); 7.1025 (2.1); 7.0949 (1.9); 7.0879 (0.5); 7.0301 (0.7); 7.0125 (0.8); 7.0069 (1.3); 7.0012 (0.7); 6.9840 (0.7); 4.4297 (0.6); 4.4212 (0.6); 4.4113 (0.6); 4.4021 (0.5); 4.1361 (1.2); 4.1191 (1.3); 4.1100 (1.6); 4.0930 (1.2); 3.6489 (1.2); 3.6414 (1.1); 3.6232 (1.1); 3.6157 (1.0); 3.4362 (9.1); 3.3120 (63.5); 2.9956 (1.3); 2.9752 (1.3); 2.9525 (1.5); 2.9321 (1.4); 2.6741 (0.7); 2.6696 (1.0); 2.6649 (0.7); 2.5230 (3.2); 2.5182 (4.8); 2.5096 (58.8); 2.5051 (125.0); 2.5005 (172.4); 2.4959 (120.9); 2.4913 (53.9); 2.4567 (1.4); 2.4477 (1.3); 2.4135 (1.1); 2.4043 (1.1); 2.3319 (0.7); 2.3273 (1.0); 2.3226 (0.7); 2.2340 (16.0); -0.0002 (7.1) I.3-16:1H NMR (400.0 MHz, CDCl3): δ= 7.5176 (1.2); 7.3267 (0.9); 7.3227 (1.0); 7.3077 (1.9); 7.3034 (2.5); 7.2886 (2.2); 7.2840 (2.4); 7.2755 (2.6); 7.2588 (208.4); 7.2418 (3.4); 7.2370 (5.9); 7.2185 (1.9); 7.2117 (1.3); 7.2034 (0.8); 7.1959 (0.8); 7.1821 (2.2); 7.1759 (1.5); 7.1721 (1.6); 7.1656 (1.0); 7.1566 (1.7); 7.1526 (2.2); 7.1475 (1.4); 7.1332 (0.8); 7.1273 (1.0); 7.1207 (1.4); 7.1172 (1.0); 7.1002 (0.9); 7.0967 (0.8); 6.9948 (1.2); 5.5897 (0.6); 4.6966 (0.5); 4.6896 (0.7); 4.6805 (0.8); 4.6713 (0.7); 4.1086 (1.2); 4.0911 (1.2); 4.0822 (1.4); 4.0653 (1.3); 3.6136 (10.6); 3.5852 (1.3); 3.5763 (1.3); 3.5590 (1.2); 3.5503 (1.1); 2.9212 (1.6); 2.9013 (1.8); 2.8777 (1.9); 2.8578 (1.9); 2.3252 (1.6); 2.3146 (1.6); 2.2846 (16.0); 2.2718 (1.4); 1.5295 (26.4); 1.2593 (0.7); 0.0079 (3.0); -0.0002 (84.0); -0.0085 (2.7) I.3-17:1H NMR (400.0MHz, d6-DMSO): δ= 8.5997 (1.4); 8.5826 (1.3); 7.8956 (3.2); 7.8899 (1.3); 7.8727 (9.8); 7.8497 (9.7); 7.8440 (1.9); 7.8325 (1.3); 7.8269 (3.0); 7.0134 (2.2); 6.9945 (3.3); 6.9509 (3.4); 6.9260 (2.2); 6.9067 (1.4); 5.7520 (3.1); 4.4371 (0.9); 4.1848 (1.6); 4.1680 (1.7); 4.1590 (1.9); 4.1425 (1.5); 3.6887 (1.5); 3.6811 (1.5); 3.6628 (1.3); 3.6555 (1.4); 3.3863 (11.0); 3.3036 (52.8); 3.0049 (1.6); 2.9847 (1.7); 2.9618 (1.9); 2.9416 (1.8); 2.6737 (1.3); 2.6688 (1.8); 2.6643 (1.3); 2.5224 (5.2); 2.5177 (7.4); 2.5090 (109.2); 2.5045 (231.4); 2.4999 (315.5); 2.4953 (220.4); 2.4908 (98.6); 2.4757 (2.4); 2.4667 (1.6); 2.4497 (0.6); 2.4328 (1.3); 2.4227 (1.4); 2.3313 (1.4); 2.3267 (1.9); 2.3224 (1.3); 2.1937 (15.6); 2.1699 (16.0); 0.1460 (0.6); 0.0080 (4.7); -0.0002 (153.6); -0.0085 (4.7); -0.1498 (0.7) I.3-20:1H NMR (400.0MHz, d6-DMSO): δ= 8.6993 (1.5); 8.6829 (1.4); 7.5397 (5.7); 7.5349 (1.8); 7.5233 (2.1); 7.5184 (6.6); 7.4174 (2.0); 7.4107 (1.1); 7.4056 (2.1); 7.4017 (1.7); 7.3942 (2.7); 7.3654 (1.4); 7.3577 (1.2); 7.3539 (2.0); 7.3480 (1.3); 7.3418 (2.5); 7.2943 (1.1); 7.2829 (5.4); 7.2816 (4.8); 7.2760 (3.1); 7.2714 (3.3); 7.2697 (3.4); 7.2654 (2.5); 7.2591 (3.8); 7.1897 (4.7); 7.1693 (4.2); 5.7550 (1.5); 4.4295 (0.7); 4.4211 (0.8); 4.4100 (0.8); 4.4023 (0.8); 4.1276 (1.8); 4.1108 (2.0); 4.1020 (2.3); 4.0853 (1.7); 3.6258 (1.7); 3.6179 (1.7); 3.5998 (1.9); 3.5901 (13.1); 3.3523 (0.6); 3.3197 (510.1); 3.2856 (0.9); 3.2701 (5.6); 2.9309 (1.7); 2.9105 (1.8); 2.8882 (2.2); 2.8678 (1.9); 2.6746 (1.0); 2.6700 (1.4); 2.6652 (1.0); 2.5235 (3.0); 2.5188 (4.4); 2.5101 (73.5); 2.5055 (163.0); 2.5009 (229.4); 2.4963 (160.8); 2.4917 (71.5); 2.4608 (1.7); 2.4560 (2.5); 2.4514 (3.0); 2.4469 (2.0); 2.4208 (1.9); 2.4115 (2.0); 2.3779 (1.6); 2.3687 (1.7); 2.3323 (1.1); 2.3276 (1.5); 2.3231 (1.0); 2.2797 (16.0); 2.0731 (1.0); 1.9882 (1.2); 1.1744 (0.7); -0.0002 (2.2) I.3-21:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5651 (2.4); 8.5488 (2.3); 7.4722 (6.8); 7.4661 (14.2); 7.4449 (11.1); 7.3701 (6.2); 7.3636 (5.4); 7.3488 (3.9); 7.3422 (3.6); 7.2551 (0.8); 7.2526 (0.7); 5.7541 (16.0); 4.5627 (0.6); 4.5107 (1.2); 4.4902 (2.3); 4.4701 (1.4); 4.4665 (1.3); 4.4466 (0.5); 4.3077 (0.6); 4.2990 (0.9); 4.2906 (1.2); 4.2812 (1.3); 4.2711 (1.2); 4.2629 (0.9); 4.2541 (0.6); 4.0384 (1.4); 4.0206 (1.4); 3.6977 (3.0); 3.6806 (3.2); 3.6723 (3.6); 3.6553 (3.0); 3.5947 (15.3); 3.3157 (59.2); 3.2474 (3.0); 3.2389 (3.0); 3.2220 (2.8); 3.2135 (2.7); 2.6485 (3.0); 2.6277 (3.4); 2.6063 (4.0); 2.5855 (3.5); 2.5238 (0.7); 2.5192 (1.1); 2.5105 (15.5); 2.5058 (34.1); 2.5012 (47.7); 2.4966 (33.2); 2.4920 (14.6); 2.1914 (0.5); 2.1803 (3.5); 2.1701 (4.9); 2.1422 (3.4); 2.1382 (5.3); 2.1278 (3.3); 2.1183 (2.5); 2.1142 (2.2); 2.0938 (0.8); 2.0895 (0.7); 2.0216 (0.6); 2.0188 (0.6); 2.0083 (1.3); 2.0063 (1.4); 1.9997 (1.6); 1.9962 (1.4); 1.9883 (8.8); 1.9809 (2.1); 1.9738 (1.9); 1.9706 (1.6); 1.9679 (1.7); 1.9626 (1.5); 1.9554 (1.6); 1.9368 (0.7); 1.6611 (0.8); 1.6521 (0.6); 1.6444 (2.4); 1.6362 (1.7); 1.6304 (2.1); 1.6198 (4.3); 1.6064 (2.5); 1.5952 (2.0); 1.5812 (0.8); 1.1927 (1.9); 1.1749 (4.0); 1.1571 (1.9); 0.0080 (1.0); -0.0002 (37.6); -0.0086 (1.0) I.3-22:1H NMR (400.0MHz, d6-DMSO): δ= 8.6320 (0.9); 8.6150 (0.9); 7.6627 (2.8); 7.6598 (3.4); 7.6548 (0.9); 7.6406 (3.9); 7.6381 (3.3); 7.3951 (2.7); 7.3898 (0.9); 7.3766 (3.6); 7.3736 (2.8); 7.3597 (1.0); 7.3549 (2.8); 7.1715 (1.0); 7.1575 (2.8); 7.1500 (1.7); 7.1394 (3.1); 7.1311 (1.5); 7.1258 (2.6); 7.1232 (2.9); 7.1149 (4.3); 7.1091 (3.4); 7.0994 (2.2); 7.0919 (2.0); 7.0853 (0.6); 4.4234 (0.6); 4.4155 (0.6); 4.4046 (0.6); 4.3957 (0.5); 4.1549 (1.5); 4.1380 (1.5); 4.1292 (1.8); 4.1125 (1.4); 3.6362 (1.2); 3.6284 (1.2); 3.6108 (1.2); 3.6029 (1.2); 3.4434 (9.1); 3.3116 (40.7); 2.9446 (1.4); 2.9243 (1.4); 2.9019 (1.7); 2.8816 (1.5); 2.6692 (0.7); 2.5227 (2.0); 2.5180 (2.8); 2.5094 (37.9); 2.5048 (81.5); 2.5002 (113.2); 2.4956 (79.1); 2.4910 (35.5); 2.4265 (1.3); 2.4174 (1.3); 2.3839 (1.2); 2.3745 (1.1); 2.3271 (0.6); 2.2346 (16.0); -0.0002 (16.3) I.3-23:1H NMR (400.0MHz, d6-DMSO): δ= 8.5308 (1.5); 8.5151 (1.5); 7.4204 (2.4); 7.4145 (1.4); 7.4077 (2.7); 7.4043 (2.2); 7.3973 (3.3); 7.3886 (0.5); 7.3544 (1.6); 7.3478 (1.5); 7.3444 (2.1); 7.3429 (1.5); 7.3372 (1.7); 7.3316 (3.1); 7.2981 (1.4); 7.2920 (0.6); 7.2863 (6.4); 7.2838 (5.4); 7.2798 (4.0); 7.2732 (6.2); 7.2671 (2.9); 7.2627 (3.5); 7.2607 (3.3); 7.2487 (0.6); 4.2971 (0.6); 4.2897 (0.9); 4.2800 (1.0); 4.2707 (0.9); 4.2640 (0.6); 3.6085 (2.6); 3.5912 (2.7); 3.5829 (3.3); 3.5704 (10.0); 3.3135 (202.8); 3.2638 (1.2); 3.1601 (2.4); 3.1511 (2.4); 3.1346 (2.2); 3.1257 (2.2); 3.0381 (1.0); 3.0189 (1.1); 3.0049 (2.6); 2.9860 (2.7); 2.9661 (2.4); 2.9478 (2.5); 2.9329 (1.0); 2.9147 (1.0); 2.6743 (0.6); 2.6697 (0.8); 2.6650 (0.6); 2.6498 (1.6); 2.6288 (1.7); 2.6076 (2.1); 2.5868 (1.9); 2.5231 (2.0); 2.5184 (2.8); 2.5097 (40.4); 2.5051 (89.6); 2.5005 (126.3); 2.4959 (87.2); 2.4913 (38.1); 2.4550 (0.6); 2.4505 (0.9); 2.4458 (0.6); 2.3319 (0.5); 2.3273 (0.8); 2.3226 (0.6); 2.2163 (2.1); 2.2057 (2.1); 2.1742 (1.8); 2.1636 (1.7); 1.8591 (0.6); 1.8412 (1.2); 1.8244 (1.6); 1.8076 (1.3); 1.7901 (0.6); 0.8324 (15.6); 0.8247 (16.0); 0.8158 (15.5); 0.8081 (15.2); -0.0002 (3.0) I.3-24:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5915 (1.3); 8.5754 (1.3); 7.5039 (0.6); 7.4922 (2.8); 7.4865 (3.2); 7.4667 (3.2); 7.4611 (2.6); 7.0346 (0.6); 7.0287 (1.0); 7.0175 (2.4); 7.0117 (1.4); 7.0057 (2.2); 6.9990 (4.0); 6.9887 (0.7); 6.9827 (1.1); 6.9771 (0.5); 6.9555 (3.3); 6.9293 (2.1); 6.9108 (1.3); 5.7537 (0.6); 4.4321 (0.6); 4.4235 (0.8); 4.4155 (0.8); 4.4044 (0.8); 4.3956 (0.7); 4.1318 (1.8); 4.1150 (1.8); 4.1057 (2.2); 4.0890 (1.7); 3.6498 (1.6); 3.6421 (1.6); 3.6236 (1.5); 3.6163 (1.4); 3.3868 (11.2); 3.3110 (50.7); 2.9957 (1.8); 2.9754 (1.9); 2.9525 (2.2); 2.9322 (1.9); 2.6741 (0.6); 2.6695 (0.8); 2.6649 (0.6); 2.5230 (2.6); 2.5183 (3.8); 2.5096 (46.4); 2.5050 (99.6); 2.5004 (137.5); 2.4958 (95.7); 2.4912 (42.4); 2.4565 (1.9); 2.4476 (1.8); 2.4134 (1.5); 2.4045 (1.5); 2.3318 (0.7); 2.3272 (0.8); 2.3226 (0.6); 2.2013 (15.5); 2.1761 (16.0); -0.0002 (6.2) I.3-25:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5923 (1.3); 8.5774 (1.3); 7.6929 (3.8); 7.6871 (1.3); 7.6806 (4.0); 7.6752 (2.0); 7.6697 (4.3); 7.6633 (1.3); 7.6574 (4.0); 7.2376 (4.2); 7.2318 (1.2); 7.2201 (1.4); 7.2156 (5.7); 7.2104 (1.3); 7.1987 (1.1); 7.1929 (3.7); 7.0151 (2.2); 6.9961 (3.3); 6.9578 (3.3); 6.9272 (2.0); 6.9085 (1.3); 5.7536 (1.0); 4.4229 (0.7); 4.4140 (0.8); 4.4056 (0.8); 4.3946 (0.8); 4.3864 (0.7); 4.1421 (1.9); 4.1254 (2.0); 4.1166 (2.4); 4.1000 (1.9); 3.6188 (1.7); 3.6112 (1.7); 3.5935 (1.5); 3.5858 (1.5); 3.3921 (11.3); 3.3102 (103.6); 3.0898 (0.6); 2.9339 (1.8); 2.9137 (2.0); 2.8911 (2.2); 2.8709 (2.0); 2.6740 (1.0); 2.6694 (1.4); 2.6647 (1.0); 2.5229 (3.7); 2.5182 (5.5); 2.5095 (80.6); 2.5049 (175.8); 2.5003 (246.2); 2.4957 (173.4); 2.4910 (77.6); 2.4183 (1.9); 2.4089 (1.9); 2.3756 (1.6); 2.3664 (1.5); 2.3317 (1.1); 2.3270 (1.5); 2.3225 (1.0); 2.2650 (0.5); 2.1986 (15.5); 2.1754 (16.0); 0.0080 (1.1); -0.0002 (36.0); -0.0085 (0.9) I.3-26:1H NMR (400.0 MHz, d6-DMSO): δ= 8.6014 (1.3); 8.5859 (1.3); 7.6619 (4.0); 7.6591 (4.9); 7.6540 (1.3); 7.6399 (5.5); 7.6374 (4.6); 7.3945 (4.0); 7.3893 (1.2); 7.3760 (5.0); 7.3730 (3.9); 7.3590 (1.3); 7.3543 (3.9); 7.1595 (1.2); 7.1567 (2.0); 7.1541 (1.1); 7.1383 (3.3); 7.1226 (0.9); 7.1199 (1.4); 7.0144 (2.2); 6.9952 (3.4); 6.9593 (3.2); 6.9263 (2.1); 6.9070 (1.4); 5.7535 (1.2); 4.4255 (0.7); 4.4168 (0.8); 4.4093 (0.9); 4.3988 (0.9); 4.3899 (0.7); 4.1514 (2.0); 4.1347 (2.0); 4.1258 (2.5); 4.1091 (1.9); 3.6379 (1.7); 3.6302 (1.7); 3.6122 (1.6); 3.6048 (1.5); 3.3938 (11.4); 3.3112 (73.0); 3.3103 (66.3); 2.9440 (1.9); 2.9238 (2.0); 2.9013 (2.4); 2.8810 (2.1); 2.6739 (0.8); 2.6693 (1.1); 2.6646 (0.8); 2.5227 (3.2); 2.5180 (4.5); 2.5094 (61.1); 2.5048 (131.8); 2.5002 (183.1); 2.4956 (126.9); 2.4910 (56.1); 2.4269 (1.8); 2.4178 (1.7); 2.3844 (1.6); 2.3752 (1.6); 2.3316 (0.9); 2.3270 (1.0); 2.3223 (0.7); 2.1965 (15.6); 2.1762 (16.0); 0.0080 (0.5); -0.0002 (19.0); -0.0085 (0.6) I.3-27:1H NMR (400.0 MHz, CDCl3): δ= 7.4922 (2.9); 7.4865 (1.0); 7.4804 (3.0); 7.4748 (1.8); 7.4692 (3.2); 7.4631 (1.0); 7.4573 (3.2); 7.2599 (44.0); 7.2513 (0.6); 7.2423 (0.7); 7.2389 (1.6); 7.2277 (2.5); 7.2232 (3.6); 7.2187 (3.7); 7.2018 (1.9); 7.1957 (1.3); 7.1854 (0.7); 7.1798 (0.9); 7.1762 (0.6); 7.1714 (1.4); 7.1680 (2.2); 7.1551 (0.5); 7.1511 (0.8); 7.0636 (3.4); 7.0578 (1.0); 7.0462 (1.2); 7.0431 (3.8); 7.0407 (3.3); 7.0374 (1.1); 7.0258 (1.0); 7.0201 (2.9); 5.6218 (0.6); 5.6064 (0.6); 4.6364 (0.7); 4.6322 (0.5); 4.6271 (0.8); 4.6222 (0.5); 4.6177 (0.6); 4.1642 (1.9); 4.1472 (1.9); 4.1382 (2.2); 4.1213 (1.9); 3.6182 (1.7); 3.6083 (1.9); 3.5988 (11.0); 3.5925 (2.0); 3.5826 (1.5); 2.9540 (1.7); 2.9331 (1.7); 2.9104 (2.0); 2.8896 (1.9); 2.6082 (1.0); 2.3496 (1.6); 2.3376 (1.6); 2.3061 (1.4); 2.2941 (1.5); 2.2682 (16.0); 1.5644 (6.0); 0.0080 (0.5); -0.0002 (16.4); -0.0085 (0.5) I.3-28:1H NMR (400.0 MHz, CDCl3): δ= 7.5180 (0.8); 7.3285 (1.0); 7.3245 (1.4); 7.3098 (2.2); 7.3052 (3.0); 7.2900 (2.2); 7.2856 (2.5); 7.2770 (1.7); 7.2705 (2.4); 7.2591 (129.0); 7.2504 (2.2); 7.2459 (1.3); 7.2378 (1.2); 7.2333 (0.9); 7.1764 (1.5); 7.1728 (1.9); 7.1575 (2.1); 7.1536 (3.1); 7.1485 (1.9); 7.1383 (1.0); 7.1343 (1.2); 7.1284 (1.5); 7.1216 (3.1); 7.1188 (3.0); 7.1011 (4.6); 7.0598 (2.2); 7.0401 (1.2); 6.9951 (1.0); 6.9859 (3.2); 5.6369 (0.9); 5.6196 (0.8); 4.6970 (0.7); 4.6897 (0.9); 4.6803 (1.0); 4.6720 (0.9); 4.6628 (0.7); 4.1062 (1.6); 4.0902 (1.6); 4.0799 (1.8); 4.0652 (1.6); 3.5918 (1.8); 3.5828 (1.9); 3.5671 (14.0); 3.5569 (1.8); 2.9204 (2.2); 2.9004 (2.3); 2.8769 (2.6); 2.8571 (2.4); 2.3305 (3.0); 2.3233 (15.8); 2.2873 (1.8); 2.2771 (1.8); 2.2274 (16.0); 1.5369 (8.9); 1.2586 (1.0); 0.0080 (1.9); -0.0002 (53.9); -0.0085 (1.8) I.3-29:1H NMR (400.0MHz, d6-DMSO): δ= 8.5421 (1.2); 8.5264 (1.2); 7.4666 (4.1); 7.4625 (5.5); 7.4603 (4.9); 7.4413 (6.5); 7.3672 (3.5); 7.3607 (3.0); 7.3458 (2.2); 7.3393 (2.0); 5.7527 (0.6); 4.2858 (0.5); 4.2785 (0.8); 4.2689 (0.8); 4.2587 (0.8); 4.2492 (0.5); 4.1922 (0.6); 4.1753 (1.5); 4.1583 (2.1); 4.1414 (1.5); 4.1244 (0.6); 3.5909 (9.5); 3.5557 (1.9); 3.5388 (2.0); 3.5304 (2.3); 3.5135 (2.0); 3.3055 (21.0); 3.0869 (1.9); 3.0782 (1.9); 3.0616 (1.7); 3.0529 (1.7); 2.6694 (0.6); 2.6249 (1.9); 2.6040 (2.1); 2.5828 (2.5); 2.5621 (2.2); 2.5228 (1.9); 2.5181 (2.7); 2.5094 (35.9); 2.5049 (77.7); 2.5002 (108.3); 2.4956 (75.4); 2.4911 (34.1); 2.3270 (0.6); 2.1750 (2.1); 2.1645 (2.0); 2.1330 (1.7); 2.1225 (1.7); 1.0628 (12.1); 1.0454 (16.0); 1.0268 (11.7); 0.0080 (1.8); -0.0002 (63.1); -0.0085 (1.9) I.3-30:1H NMR (400.0MHz, d6-DMSO): δ= 8.5935 (1.5); 8.5783 (1.5); 8.1378 (3.2); 8.1348 (3.4); 8.0274 (1.3); 8.0213 (1.3); 8.0121 (2.0); 8.0038 (1.5); 7.9980 (1.2); 7.6036 (6.2); 7.6016 (5.9); 7.5954 (2.8); 7.5919 (2.8); 7.5876 (3.4); 7.0164 (2.3); 6.9976 (3.4); 6.9563 (3.4); 6.9280 (2.2); 6.9093 (1.4); 5.7530 (5.6); 4.4386 (1.0); 4.1782 (1.6); 4.1615 (1.6); 4.1523 (2.0); 4.1356 (1.6); 3.6829 (1.6); 3.6750 (1.7); 3.6569 (1.5); 3.6495 (1.4); 3.4284 (0.9); 3.3904 (11.5); 3.3082 (241.4); 3.2579 (1.0); 2.9852 (1.6); 2.9651 (1.8); 2.9423 (2.0); 2.9221 (1.8); 2.6737 (2.4); 2.6693 (3.2); 2.6647 (2.5); 2.6202 (1.6); 2.5226 (18.7); 2.5179 (22.7); 2.5092 (177.7); 2.5047 (368.5); 2.5001 (509.9); 2.4956 (368.9); 2.4911 (175.8); 2.4637 (2.4); 2.4542 (2.9); 2.4491 (2.2); 2.4445 (2.4); 2.4208 (1.8); 2.4116 (1.8); 2.3316 (2.3); 2.3270 (3.0); 2.3223 (2.3); 2.1974 (15.8); 2.1765 (16.0); 1.9877 (0.7); 1.2415 (1.3); 0.8547 (0.7); -0.0002 (18.4) I.3-31:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.7210 (0.9); 8.7046 (0.8); 7.5549 (3.3); 7.5493 (1.0); 7.5377 (1.2); 7.5321 (3.6); 7.4809 (2.0); 7.4744 (2.2); 7.4597 (1.9); 7.4383 (3.0); 7.3668 (1.6); 7.3603 (1.4); 7.3454 (1.0); 7.3389 (0.9); 6.9535 (3.6); 6.9479 (1.0); 6.9362 (1.0); 6.9307 (3.2); 4.1172 (0.8); 4.1004 (0.9); 4.0916 (1.0); 4.0750 (0.8); 3.7424 (16.0); 3.6137 (5.5); 3.6011 (1.0); 3.5933 (0.9); 3.5754 (0.8); 3.5679 (0.8); 3.3172 (54.3); 2.9145 (0.8); 2.8941 (0.8); 2.8719 (1.0); 2.8515 (0.9); 2.5472 (0.5); 2.5232 (1.8); 2.5100 (18.9); 2.5055 (38.1); 2.5010 (51.1); 2.4964 (35.8); 2.4919 (16.4); 2.4559 (0.6); 2.4514 (0.6); 2.3978 (0.9); 2.3887 (0.9); 2.3553 (0.8); 2.3462 (0.8); 1.9884 (0.5); 0.0080 (0.7); -0.0002 (19.4); -0.0086 (0.8) I.3-32:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4034 (1.2); 8.3877 (1.1); 7.0188 (2.2); 6.9998 (3.3); 6.9604 (3.3); 6.9321 (2.1); 6.9128 (1.3); 5.7520 (1.4); 4.2761 (0.6); 4.2688 (0.8); 4.2592 (1.0); 4.2493 (0.8); 4.2423 (0.6); 4.1875 (0.6); 4.1705 (1.6); 4.1536 (2.2); 4.1366 (1.6); 4.1196 (0.6); 3.5464 (2.0); 3.5295 (2.2); 3.5212 (2.4); 3.5043 (2.1); 3.4169 (0.7); 3.3798 (5.3); 3.3702 (5.4); 3.3332 (0.8); 3.3053 (27.6); 3.0572 (2.0); 3.0483 (2.0); 3.0320 (1.8); 3.0231 (1.8); 2.6117 (2.1); 2.5909 (2.2); 2.5698 (2.7); 2.5490 (2.3); 2.5223 (1.4); 2.5176 (1.9); 2.5090 (28.1); 2.5044 (62.0); 2.4998 (87.1); 2.4952 (61.0); 2.4906 (27.8); 2.4500 (0.5); 2.3265 (0.5); 2.2221 (15.4); 2.1819 (16.0); 2.1693 (2.5); 2.1585 (2.3); 2.1274 (1.8); 2.1166 (1.9); 1.0487 (12.9); 1.0393 (13.0); 1.0318 (13.3); 1.0224 (12.7); -0.0002 (13.2) I.3-33:1H NMR (400.0MHz, d6-DMSO): δ= 8.4331 (0.8); 8.4172 (0.8); 7.1643 (0.8); 7.1510 (1.8); 7.1424 (2.0); 7.1342 (1.3); 7.1283 (2.7); 7.1259 (2.4); 7.1180 (4.5); 7.1128 (3.3); 7.1036 (2.1); 7.0971 (1.2); 7.0947 (1.0); 7.0913 (0.6); 4.2730 (0.6); 4.2633 (0.7); 4.2534 (0.6); 4.1701 (1.1); 4.1531 (1.5); 4.1361 (1.1); 3.5496 (1.4); 3.5326 (1.5); 3.5244 (1.7); 3.5074 (1.5); 3.4270 (4.3); 3.4194 (4.4); 3.3065 (35.2); 3.0606 (1.4); 3.0515 (1.4); 3.0354 (1.3); 3.0264 (1.3); 2.6123 (1.4); 2.5914 (1.5); 2.5703 (1.9); 2.5495 (1.5); 2.5225 (1.1); 2.5178 (1.6); 2.5091 (23.8); 2.5045 (51.4); 2.4999 (71.8); 2.4953 (50.5); 2.4907 (22.9); 2.2377 (16.0); 2.1693 (1.6); 2.1583 (1.6); 2.1274 (1.3); 2.1164 (1.3); 1.0500 (9.0); 1.0396 (9.2); 1.0331 (9.4); 1.0227 (8.8) I.3-34:1H NMR (400.0MHz, d6-DMSO): δ= 7.5210 (11.0); 7.4573 (15.5); 7.4291 (11.2); 7.4162 (9.6); 7.3973 (8.9); 5.3584 (9.7); 5.3277 (7.9); 4.0832 (10.1); 3.4321 (8.6); 3.3112 (4874.4); 3.2610 (55.6); 3.2210 (8.2); 2.6695 (32.5); 2.5094 (2043.6); 2.5050 (3959.1); 2.5005 (5216.0); 2.4959 (3820.1); 2.4915 (1932.9); 2.4552 (70.8); 2.4505 (77.9); 2.4458 (57.7); 2.4099 (21.6); 2.3272 (35.9); 1.0554 (7.3); 0.8201 (11.8); 0.8035 (16.0); 0.7754 (12.8); 0.6877 (11.8); 0.6713 (10.2); 0.0079 (36.9); -0.0002 (893.7); -0.0504 (14.4) I.3-35:1H NMR (400.0MHz, d6-DMSO): δ= 8.5374 (1.8); 8.5211 (1.8); 7.4252 (2.6); 7.4197 (1.6); 7.4145 (1.5); 7.4119 (2.4); 7.4088 (2.3); 7.4021 (3.6); 7.3932 (0.6); 7.3603 (1.8); 7.3535 (1.5); 7.3504 (2.1); 7.3478 (1.6); 7.3425 (1.9); 7.3371 (3.4); 7.3089 (0.5); 7.3027 (1.5); 7.2957 (0.6); 7.2905 (6.3); 7.2874 (5.6); 7.2843 (4.3); 7.2771 (8.5); 7.2703 (3.2); 7.2671 (3.6); 7.2641 (3.2); 7.2520 (0.7); 5.7538 (1.1); 4.5330 (0.7); 4.5144 (1.0); 4.4909 (1.9); 4.4708 (1.1); 4.4673 (1.0); 4.3030 (0.7); 4.2950 (1.0); 4.2855 (1.1); 4.2757 (1.0); 4.2678 (0.7); 4.0559 (1.0); 4.0381 (3.1); 4.0203 (3.1); 4.0025 (1.0); 3.6988 (2.4); 3.6816 (2.6); 3.6735 (3.0); 3.6563 (2.5); 3.6166 (0.8); 3.5780 (8.1); 3.5706 (8.2); 3.5320 (0.8); 3.3154 (55.5); 3.2555 (2.5); 3.2468 (2.5); 3.2301 (2.2); 3.2215 (2.2); 2.6448 (2.5); 2.6239 (2.8); 2.6025 (3.3); 2.5817 (2.9); 2.5231 (0.7); 2.5184 (1.0); 2.5097 (12.8); 2.5051 (28.0); 2.5005 (39.1); 2.4959 (27.1); 2.4913 (11.9); 2.1953 (0.6); 2.1880 (3.0); 2.1775 (3.1); 2.1705 (1.9); 2.1457 (5.1); 2.1354 (2.7); 2.1269 (1.0); 2.1195 (2.4); 2.0951 (0.8); 2.0193 (0.5); 2.0168 (0.5); 2.0063 (1.0); 2.0040 (1.1); 1.9990 (1.4); 1.9879 (16.0); 1.9837 (1.7); 1.9786 (1.7); 1.9727 (1.6); 1.9694 (1.4); 1.9662 (1.4); 1.9625 (1.2); 1.9586 (1.1); 1.9541 (1.2); 1.9463 (0.6); 1.9364 (0.6); 1.6607 (0.7); 1.6442 (2.0); 1.6358 (1.4); 1.6306 (1.8); 1.6198 (3.6); 1.6064 (2.0); 1.5952 (1.6); 1.5808 (0.6); 1.1922 (4.5); 1.1744 (8.9); 1.1566 (4.4); 0.0079 (0.8); -0.0002 (25.7); -0.0027 (1.1); -0.0085 (0.7) I.3-36:1H NMR (400.0MHz, d6-DMSO): δ= 15.5677 (2.2); 15.5575 (1.9); 8.9875 (0.7); 8.9712 (0.6); 8.9426 (0.6); 8.9267 (0.6); 7.5529 (1.2); 7.5496 (1.4); 7.5343 (1.5); 7.5330 (1.6); 7.5306 (1.8); 7.4965 (0.8); 7.4905 (1.3); 7.4846 (1.3); 7.4802 (1.0); 7.4775 (0.8); 7.4738 (1.4); 7.4672 (1.1); 7.4565 (0.8); 7.4496 (0.6); 7.4446 (1.1); 7.4378 (1.5); 7.4320 (2.2); 7.4244 (1.4); 7.4217 (1.8); 7.4141 (2.0); 7.4085 (1.9); 7.3978 (0.8); 7.3946 (0.9); 7.3919 (0.9); 7.3890 (1.1); 7.3860 (0.8); 7.3832 (0.8); 7.3794 (0.7); 7.3772 (0.9); 7.3714 (1.2); 7.3645 (3.4); 7.3613 (2.7); 7.3589 (2.2); 7.3534 (2.6); 7.3512 (3.6); 7.3470 (3.0); 7.3411 (3.6); 7.3373 (3.2); 7.3316 (1.9); 7.3228 (0.9); 7.3180 (0.8); 7.3093 (1.9); 7.3030 (2.2); 7.3002 (2.5); 7.2941 (3.1); 7.2860 (4.4); 7.2797 (3.9); 7.2763 (2.6); 7.2697 (2.4); 7.2617 (1.0); 7.2572 (2.6); 7.2527 (2.1); 7.2464 (1.9); 7.2398 (2.3); 7.2341 (1.0); 7.2282 (1.4); 7.2224 (1.0); 7.2100 (0.5); 7.2043 (0.7); 7.1828 (0.6); 7.1743 (0.6); 7.1548 (0.5); 5.7541 (3.4); 5.2951 (2.9); 5.2706 (2.6); 4.4848 (0.6); 4.4563 (0.7); 4.4393 (0.6); 4.3554 (0.5); 4.3476 (0.5); 4.0915 (1.1); 4.0559 (1.2); 4.0480 (2.3); 4.0381 (3.4); 4.0203 (3.4); 4.0025 (1.1); 3.9833 (3.4); 3.9397 (1.6); 3.7665 (0.6); 3.7496 (0.6); 3.7408 (0.8); 3.7240 (0.6); 3.7167 (0.6); 3.7070 (0.6); 3.6966 (0.8); 3.6916 (1.0); 3.6810 (0.9); 3.6757 (0.7); 3.6651 (0.6); 3.3649 (1.2); 3.3584 (1.6); 3.3416 (2.4); 3.3324 (0.9); 3.3238 (1.2); 3.3133 (122.9); 3.2632 (1.0); 3.2494 (0.6); 3.2421 (0.5); 3.2162 (0.5); 3.1871 (0.6); 3.1728 (0.7); 3.1628 (0.6); 3.1575 (0.5); 3.1493 (0.7); 2.6974 (0.6); 2.6817 (0.7); 2.6769 (0.8); 2.6696 (0.7); 2.6649 (0.5); 2.6609 (0.9); 2.6550 (0.7); 2.6393 (0.8); 2.6346 (0.7); 2.6186 (0.7); 2.5231 (1.8); 2.5184 (2.8); 2.5097 (33.9); 2.5051 (74.6); 2.5005 (104.4); 2.4959 (73.1); 2.4913 (32.3); 2.4766 (1.0); 2.4710 (0.7); 2.4515 (1.6); 2.4456 (0.9); 2.4288 (0.7); 2.3273 (0.7); 2.3226 (0.5); 2.3153 (0.7); 2.2997 (0.7); 2.2855 (0.6); 2.2730 (0.5); 2.2688 (0.6); 2.1867 (1.2); 2.1777 (0.8); 2.1616 (1.3); 2.1443 (1.4); 2.1366 (1.8); 2.1131 (1.5); 2.1035 (1.0); 2.0921 (0.7); 2.0709 (1.0); 2.0613 (0.9); 1.9879 (16.0); 1.9685 (0.9); 1.9535 (1.0); 1.9379 (1.1); 1.9292 (0.9); 1.9106 (0.7); 1.6416 (0.6); 1.6257 (1.0); 1.6176 (1.5); 1.6090 (1.4); 1.6005 (1.6); 1.5947 (1.6); 1.5851 (1.4); 1.5609 (0.5); 1.2357 (0.6); 1.1922 (4.7); 1.1745 (9.6); 1.1567 (4.7); 0.0080 (2.0); 0.0063 (0.6); 0.0054 (0.6); 0.0046 (0.8); -0.0002 (70.4); -0.0052 (0.9); -0.0060 (0.7); -0.0068 (0.6); -0.0085 (2.0) I.3-37:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.5319 (6.8); 7.5109 (8.2); 7.4195 (8.0); 7.3799 (15.1); 7.3588 (16.0); 7.1665 (7.6); 7.1444 (5.5); 3.6619 (9.0); 3.3128 (232.5); 2.6695 (5.7); 2.5093 (399.5); 2.5048 (844.3); 2.5002 (1177.8); 2.4955 (845.7); 2.4910 (391.1); 2.4501 (5.9); 2.3270 (6.2); 0.0079 (12.6); -0.0002 (396.5); -0.0085 (14.3) I.4-11:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0560 (3.6); 8.0504 (3.6); 7.7346 (9.3); 7.7290 (2.3); 7.7174 (2.2); 7.7118 (8.1); 7.7037 (0.7); 7.4571 (0.8); 7.4491 (8.4); 7.4436 (2.2); 7.4319 (2.0); 7.4264 (7.1); 7.4183 (0.6); 7.3082 (1.8); 7.2917 (1.8); 7.1445 (2.4); 7.1430 (2.3); 7.1242 (2.7); 7.1227 (2.7); 6.9179 (2.4); 6.9121 (2.3); 6.8977 (2.0); 6.8920 (2.0); 4.4047 (0.5); 4.3974 (0.7); 4.3884 (0.8); 4.3795 (0.7); 4.3720 (0.6); 4.1695 (1.6); 4.1535 (1.6); 4.1440 (2.0); 4.1281 (1.5); 3.6956 (1.4); 3.6872 (1.3); 3.6701 (1.3); 3.6621 (1.2); 3.3655 (0.6); 3.3152 (123.1); 3.0031 (1.6); 2.9837 (1.7); 2.9606 (2.0); 2.9412 (1.7); 2.5236 (1.3); 2.5189 (1.8); 2.5102 (24.7); 2.5056 (53.8); 2.5010 (75.4); 2.4964 (52.3); 2.4918 (22.8); 2.4449 (1.6); 2.4348 (1.5); 2.4024 (1.4); 2.3924 (1.3); 2.1383 (16.0); 2.0728 (0.8); 0.0080 (1.2); -0.0002 (42.8); -0.0085 (1.2) I.4-12:1H NMR (400.0MHz, d6-DMSO): δ= 8.9179 (0.8); 8.5518 (4.1); 7.6652 (5.1); 7.6457 (6.3); 7.4692 (1.0); 7.4565 (1.1); 7.4462 (1.2); 7.4342 (1.1); 7.4105 (3.6); 7.3943 (6.0); 7.3887 (5.0); 7.3757 (9.6); 7.3545 (3.7); 7.1548 (2.0); 7.1364 (3.4); 7.1179 (1.9); 7.1095 (1.9); 7.0868 (1.3); 7.0779 (3.9); 7.0559 (6.9); 7.0337 (3.3); 6.8158 (2.2); 6.7993 (2.4); 4.3877 (1.3); 4.3789 (1.2); 4.1531 (2.0); 4.1362 (2.1); 4.1276 (2.4); 4.1111 (2.0); 3.6928 (2.0); 3.6833 (2.0); 3.6674 (1.9); 3.6579 (2.4); 3.3175 (18.7); 3.0806 (3.0); 3.0625 (3.0); 2.9439 (1.8); 2.9239 (2.0); 2.9014 (2.3); 2.8819 (2.1); 2.5059 (44.0); 2.5016 (56.3); 2.4977 (40.0); 2.4714 (3.0); 2.4599 (2.7); 2.4286 (1.9); 2.4174 (1.8); 2.0730 (1.6); 1.2056 (7.9); 1.1873 (16.0); 1.1692 (7.7); -0.0002 (2.4) I.4-21:1H NMR (400.0MHz, d6-DMSO): δ= 8.1638 (4.0); 8.1600 (3.9); 8.1430 (4.3); 8.1391 (4.0); 7.9748 (6.0); 7.7398 (1.5); 7.7317 (11.6); 7.7261 (3.4); 7.7144 (3.9); 7.7089 (13.3); 7.7010 (1.1); 7.6234 (2.9); 7.6075 (2.8); 7.4580 (1.7); 7.4500 (14.2); 7.4445 (3.8); 7.4328 (3.5); 7.4273 (11.5); 7.4192 (1.2); 7.4089 (4.2); 7.4053 (4.5); 7.3890 (4.8); 7.3852 (4.6); 7.2660 (2.1); 7.2622 (2.0); 7.2445 (3.3); 7.2266 (2.2); 7.2230 (2.0); 6.9840 (3.3); 6.9800 (3.0); 6.9655 (3.5); 6.9616 (3.3); 6.9456 (2.6); 6.9416 (2.3); 4.4015 (1.4); 4.3923 (1.5); 4.1720 (2.6); 4.1560 (2.8); 4.1465 (3.4); 4.1306 (2.5); 4.0559 (0.9); 4.0381 (2.4); 4.0204 (2.2); 4.0024 (0.8); 3.6926 (2.3); 3.6854 (2.3); 3.6677 (2.3); 3.6594 (2.2); 3.3751 (3.5); 3.3275 (386.4); 3.2762 (5.1); 3.2238 (0.6); 3.1127 (0.9); 3.1008 (1.0); 3.0944 (1.0); 3.0825 (1.0); 3.0040 (2.7); 2.9848 (3.0); 2.9615 (3.4); 2.9420 (3.0); 2.6745 (2.5); 2.6699 (3.4); 2.6652 (2.4); 2.5465 (3.6); 2.5234 (9.1); 2.5187 (13.2); 2.5100 (188.1); 2.5054 (411.0); 2.5008 (576.8); 2.4961 (404.4); 2.4915 (180.2); 2.4599 (2.7); 2.4553 (5.1); 2.4505 (7.5); 2.4460 (6.3); 2.4357 (3.9); 2.4259 (3.0); 2.3928 (2.8); 2.3832 (2.6); 2.3323 (2.6); 2.3275 (3.4); 2.3229 (2.5); 2.0725 (11.7); 1.9880 (10.9); 1.9081 (16.0); 1.1956 (1.8); 1.1923 (3.4); 1.1773 (4.0); 1.1746 (6.8); 1.1568 (3.4); 0.1463 (0.7); 0.0080 (6.5); 0.0056 (1.5); -0.0002 (237.8); -0.0085 (7.6); -0.0504 (2.2); -0.1496 (0.8) I.4-29:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.1683 (2.5); 8.1645 (2.6); 8.1475 (2.8); 8.1436 (2.6); 7.9763 (3.8); 7.6271 (1.9); 7.6108 (1.9); 7.5661 (0.7); 7.5594 (5.8); 7.5546 (1.8); 7.5429 (1.9); 7.5380 (6.6); 7.5315 (0.6); 7.4074 (2.9); 7.4038 (2.9); 7.3874 (3.2); 7.3837 (3.0); 7.2646 (1.3); 7.2609 (1.2); 7.2460 (1.8); 7.2431 (2.2); 7.2254 (1.5); 7.2216 (1.4); 7.1965 (4.4); 7.1951 (4.8); 7.1747 (4.3); 7.1732 (3.7); 6.9813 (2.0); 6.9774 (2.1); 6.9629 (2.2); 6.9614 (2.2); 6.9590 (2.2); 6.9575 (2.2); 6.9430 (1.8); 6.9390 (1.6); 4.3940 (0.6); 4.3859 (0.8); 4.3777 (0.9); 4.3679 (0.8); 4.3603 (0.6); 4.1538 (1.9); 4.1379 (1.9); 4.1281 (2.3); 4.1124 (1.7); 3.6603 (1.6); 3.6524 (1.5); 3.6347 (1.5); 3.6268 (1.4); 3.3799 (0.8); 3.3311 (66.4); 3.2805 (1.2); 3.1108 (0.5); 3.0987 (0.5); 3.0925 (0.6); 3.0806 (0.6); 2.9767 (1.8); 2.9575 (1.9); 2.9344 (2.2); 2.9152 (1.9); 2.6746 (0.6); 2.6700 (0.8); 2.6653 (0.6); 2.5556 (0.8); 2.5513 (1.0); 2.5466 (0.8); 2.5235 (2.2); 2.5188 (3.1); 2.5101 (43.8); 2.5055 (96.0); 2.5009 (135.3); 2.4963 (93.9); 2.4917 (41.2); 2.4600 (0.8); 2.4556 (1.4); 2.4510 (1.8); 2.4464 (1.3); 2.4004 (1.9); 2.3908 (1.8); 2.3579 (1.5); 2.3484 (1.5); 2.3324 (0.7); 2.3277 (0.9); 2.3230 (0.7); 2.2801 (16.0); 1.9880 (0.6); 1.9084 (13.6); 1.1964 (1.0); 1.1782 (2.1); 1.1747 (0.6); 1.1600 (1.0); 0.0080 (0.7); -0.0002 (25.0); -0.0085 (0.7) I.4-30:1H NMR (400.0MHz, d6-DMSO): δ= 8.1120 (0.5); 8.1067 (0.5); 8.0643 (3.5); 8.0586 (3.4); 7.8610 (3.5); 7.7410 (0.6); 7.7200 (0.5); 7.7172 (0.6); 7.6915 (3.5); 7.6886 (4.4); 7.6835 (1.1); 7.6695 (4.8); 7.6669 (4.0); 7.4094 (0.7); 7.4008 (3.4); 7.3956 (1.1); 7.3877 (1.2); 7.3823 (4.4); 7.3794 (3.4); 7.3692 (0.7); 7.3654 (1.2); 7.3606 (3.4); 7.2282 (1.7); 7.2114 (1.6); 7.1599 (4.2); 7.1577 (3.2); 7.1415 (4.2); 7.1394 (4.2); 7.1259 (0.9); 7.1232 (1.5); 7.1205 (0.8); 6.9293 (2.3); 6.9235 (2.3); 6.9092 (2.0); 6.9033 (2.2); 4.1188 (1.1); 4.1005 (2.5); 4.0854 (1.5); 4.0784 (2.3); 4.0570 (1.1); 4.0396 (0.9); 3.6095 (1.2); 3.5947 (1.8); 3.5881 (1.7); 3.5727 (0.8); 3.3109 (107.6); 3.2608 (0.8); 2.6740 (0.7); 2.6695 (1.0); 2.6650 (0.8); 2.6230 (1.2); 2.6048 (1.6); 2.5852 (1.2); 2.5230 (2.4); 2.5184 (3.5); 2.5097 (54.9); 2.5051 (120.8); 2.5004 (168.9); 2.4958 (117.7); 2.4912 (52.0); 2.4596 (0.9); 2.4552 (1.4); 2.4505 (1.6); 2.4459 (1.1); 2.4412 (0.5); 2.3318 (0.8); 2.3272 (1.1); 2.3226 (0.8); 2.2544 (0.7); 2.1705 (16.0); 2.1289 (2.4); 1.2301 (11.3); 1.2122 (11.0); 1.1729 (0.8); 1.1195 (1.5); 1.1012 (1.5); 0.0081 (2.0); -0.0002 (75.4); -0.0086 (2.2); -0.0502 (0.6) I.4-39:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0631 (3.6); 8.0574 (3.6); 7.7333 (3.5); 7.5685 (0.7); 7.5619 (5.3); 7.5571 (1.6); 7.5455 (1.8); 7.5405 (6.0); 7.5340 (0.6); 7.3153 (1.7); 7.2989 (1.8); 7.1957 (4.0); 7.1942 (4.3); 7.1738 (3.9); 7.1722 (3.4); 7.1425 (2.4); 7.1409 (2.3); 7.1222 (2.7); 7.1207 (2.7); 6.9140 (2.4); 6.9084 (2.4); 6.8941 (2.0); 6.8883 (2.0); 4.3888 (0.5); 4.3813 (0.8); 4.3721 (0.8); 4.3633 (0.8); 4.3556 (0.6); 4.1511 (1.7); 4.1352 (1.7); 4.1255 (2.1); 4.1097 (1.6); 3.6624 (1.4); 3.6543 (1.4); 3.6369 (1.3); 3.6289 (1.2); 3.3411 (0.5); 3.3131 (184.7); 3.2805 (0.7); 3.2634 (1.5); 2.9757 (1.6); 2.9564 (1.8); 2.9334 (2.0); 2.9141 (1.8); 2.6743 (0.6); 2.6697 (0.8); 2.6650 (0.5); 2.5232 (2.4); 2.5185 (3.6); 2.5098 (43.9); 2.5052 (95.3); 2.5006 (133.6); 2.4959 (92.4); 2.4913 (40.4); 2.4690 (0.8); 2.4595 (0.7); 2.4553 (1.0); 2.4508 (1.2); 2.4460 (0.9); 2.4082 (1.5); 2.3986 (1.6); 2.3660 (1.3); 2.3562 (1.3); 2.3320 (0.6); 2.3274 (0.9); 2.3226 (0.6); 2.2797 (14.5); 2.2540 (0.6); 2.1379 (16.0); 2.0725 (0.5); 1.1764 (0.6); 0.0080 (2.2); -0.0002 (82.8); -0.0086 (2.4); -0.0500 (0.6) I.4-42:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4569 (1.8); 8.0140 (1.1); 8.0059 (1.1); 7.9978 (1.1); 7.9896 (1.1); 7.9857 (1.1); 7.9775 (1.0); 7.9694 (1.0); 7.9613 (0.9); 7.7290 (0.8); 7.7209 (7.3); 7.7154 (2.1); 7.7038 (2.4); 7.6982 (8.6); 7.6902 (0.7); 7.4555 (1.0); 7.4475 (9.0); 7.4419 (2.3); 7.4303 (2.2); 7.4248 (7.6); 7.4167 (0.6); 7.3144 (1.8); 7.2977 (1.8); 7.2589 (1.0); 7.2460 (1.2); 7.2363 (1.2); 7.2314 (1.1); 7.2233 (1.2); 7.2184 (1.2); 7.2088 (1.1); 7.1957 (1.1); 6.7789 (0.7); 6.7701 (1.1); 6.7616 (0.8); 6.7592 (0.9); 6.7564 (0.8); 6.7499 (1.3); 6.7417 (0.7); 6.7366 (0.6); 6.7279 (0.9); 4.4168 (0.6); 4.4091 (0.8); 4.4004 (0.9); 4.3914 (0.8); 4.3838 (0.6); 4.1648 (1.8); 4.1484 (1.9); 4.1393 (2.2); 4.1231 (1.7); 4.0560 (0.5); 4.0383 (1.6); 4.0205 (1.6); 4.0027 (0.6); 3.6915 (1.7); 3.6827 (1.7); 3.6662 (1.7); 3.6573 (1.7); 3.5502 (1.3); 2.9905 (1.8); 2.9711 (1.9); 2.9481 (2.2); 2.9285 (2.0); 2.6747 (0.6); 2.6700 (0.8); 2.6654 (0.6); 2.5235 (2.5); 2.5188 (3.7); 2.5101 (48.2); 2.5055 (104.2); 2.5009 (144.6); 2.4963 (100.0); 2.4917 (43.8); 2.4554 (0.6); 2.4508 (0.9); 2.4444 (2.0); 2.4336 (1.7); 2.4019 (1.5); 2.3913 (1.4); 2.3323 (0.7); 2.3276 (0.9); 2.3231 (0.7); 1.9881 (7.4); 1.9084 (16.0); 1.1984 (0.7); 1.1925 (2.2); 1.1802 (1.5); 1.1747 (4.4); 1.1621 (0.7); 1.1569 (2.1); 0.0080 (1.3); -0.0002 (46.8); -0.0086 (1.4) I.4-43:1H NMR (400.0MHz, d6-DMSO): δ= 8.4499 (1.7); 8.0179 (1.0); 8.0096 (1.0); 8.0016 (1.1); 7.9936 (1.0); 7.9893 (1.1); 7.9813 (1.0); 7.9731 (1.0); 7.9650 (1.0); 7.5471 (5.6); 7.5423 (1.6); 7.5307 (1.9); 7.5258 (6.4); 7.5191 (0.6); 7.3115 (1.7); 7.2949 (1.9); 7.2575 (1.0); 7.2445 (1.2); 7.2348 (1.2); 7.2300 (1.2); 7.2218 (1.2); 7.2170 (1.2); 7.2072 (1.2); 7.1940 (5.2); 7.1925 (4.9); 7.1720 (4.1); 7.1704 (3.6); 6.7761 (0.7); 6.7673 (1.0); 6.7564 (0.8); 6.7471 (1.3); 6.7389 (0.7); 6.7248 (0.9); 4.3928 (0.8); 4.3840 (0.9); 4.3756 (0.8); 4.1458 (1.8); 4.1297 (1.8); 4.1203 (2.3); 4.1040 (1.6); 3.6578 (1.5); 3.6492 (1.5); 3.6326 (1.5); 3.6242 (1.4); 3.3706 (26.6); 3.1089 (1.4); 3.0969 (1.4); 3.0906 (1.4); 3.0787 (1.4); 2.9634 (1.7); 2.9439 (1.9); 2.9211 (2.1); 2.9016 (1.9); 2.6744 (1.1); 2.6697 (1.6); 2.6651 (1.2); 2.5504 (0.7); 2.5457 (0.6); 2.5232 (4.0); 2.5185 (5.8); 2.5098 (87.0); 2.5052 (191.8); 2.5006 (268.7); 2.4960 (186.7); 2.4914 (81.8); 2.4597 (0.8); 2.4548 (1.2); 2.4503 (1.6); 2.4458 (1.4); 2.4073 (1.9); 2.3968 (1.8); 2.3649 (1.6); 2.3544 (1.5); 2.3367 (0.6); 2.3321 (1.3); 2.3274 (1.8); 2.3227 (1.3); 2.3180 (0.6); 2.2791 (15.3); 2.0725 (1.0); 1.9879 (1.1); 1.9081 (16.0); 1.1976 (2.6); 1.1794 (5.6); 1.1745 (0.9); 1.1611 (2.6); -0.0002 (16.0); -0.0085 (0.5) I.4-44:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.2290 (3.8); 8.2230 (3.6); 8.1023 (1.9); 8.0982 (1.9); 8.0816 (3.4); 8.0774 (3.4); 8.0609 (1.9); 8.0568 (1.7); 7.9072 (6.2); 7.9016 (2.4); 7.8900 (3.9); 7.8843 (15.9); 7.8797 (2.7); 7.8619 (3.0); 7.8573 (16.0); 7.8515 (3.2); 7.8401 (2.3); 7.8345 (6.2); 7.7652 (0.9); 7.7428 (0.7); 7.2088 (3.2); 7.1988 (2.9); 7.1950 (3.8); 7.1785 (2.5); 7.1748 (2.5); 7.1698 (2.1); 7.1661 (2.2); 7.1492 (2.3); 7.1457 (2.5); 7.1038 (1.7); 7.0845 (3.3); 7.0648 (1.9); 6.9714 (1.5); 6.9672 (1.6); 6.9586 (1.5); 6.9542 (2.0); 6.9483 (1.7); 6.9399 (1.7); 6.9355 (1.7); 6.9281 (0.9); 6.9196 (0.9); 6.9155 (0.8); 5.7537 (4.6); 4.4263 (1.4); 4.4176 (1.5); 4.4092 (1.5); 4.4009 (1.1); 4.2050 (2.7); 4.1886 (2.9); 4.1793 (3.4); 4.1630 (2.6); 3.7511 (2.3); 3.7418 (2.4); 3.7256 (2.2); 3.7162 (2.1); 3.3647 (3.3); 3.3492 (2.3); 3.3150 (562.8); 3.2845 (1.6); 3.2648 (4.7); 3.2162 (0.5); 3.0336 (2.7); 3.0140 (3.0); 2.9908 (3.5); 2.9712 (3.0); 2.6746 (1.5); 2.6699 (2.1); 2.6654 (1.4); 2.5552 (1.7); 2.5508 (2.5); 2.5462 (2.4); 2.5348 (1.6); 2.5300 (1.1); 2.5235 (4.6); 2.5188 (7.1); 2.5101 (108.1); 2.5055 (236.0); 2.5009 (331.8); 2.4963 (231.6); 2.4917 (104.9); 2.4696 (2.0); 2.4566 (4.0); 2.4509 (4.1); 2.4468 (5.1); 2.3324 (1.4); 2.3277 (2.1); 2.3232 (1.5); 2.0727 (0.6); 1.1744 (1.0); 0.8584 (0.7); 0.0080 (1.7); -0.0002 (63.7); -0.0086 (2.0) I.4-45:1H NMR (400.0MHz, d6-DMSO): δ= 7.9073 (1.0); 7.9012 (1.1); 7.8840 (5.2); 7.8781 (6.1); 7.8736 (6.6); 7.8714 (5.6); 7.8505 (1.1); 7.8477 (0.7); 7.7149 (0.9); 7.7107 (1.3); 7.7039 (1.3); 7.6947 (1.1); 7.6907 (1.9); 7.6888 (1.1); 7.6852 (1.2); 7.5954 (0.8); 7.5907 (1.0); 7.5773 (1.9); 7.5722 (2.0); 7.5592 (1.6); 7.5525 (2.2); 7.5479 (0.8); 7.5409 (1.3); 7.5365 (1.5); 7.5330 (1.2); 7.5290 (1.4); 7.5224 (0.6); 7.5181 (0.6); 7.5147 (0.8); 7.5107 (0.7); 7.4980 (1.6); 7.4953 (1.6); 7.4914 (1.6); 7.4795 (1.0); 7.4763 (0.9); 5.7537 (16.0); 5.0869 (0.5); 5.0680 (0.8); 4.4238 (0.6); 4.4181 (0.6); 4.4038 (0.7); 4.3966 (1.1); 4.3903 (0.9); 4.3760 (0.6); 4.3693 (0.6); 4.1949 (0.6); 4.1894 (0.6); 4.1677 (0.5); 4.1614 (0.5); 4.0773 (0.6); 4.0717 (0.6); 4.0493 (0.6); 4.0436 (0.5); 3.3349 (25.3); 3.2438 (0.7); 3.2262 (0.6); 3.2191 (0.7); 3.1987 (0.9); 3.1812 (0.9); 3.1743 (0.7); 3.1569 (0.7); 3.0161 (0.8); 3.0094 (0.8); 2.9709 (0.6); 2.9641 (0.6); 2.9022 (0.7); 2.8956 (0.7); 2.8574 (0.6); 2.8507 (0.6); 2.6741 (1.1); 2.6695 (1.5); 2.6649 (1.1); 2.5229 (3.6); 2.5182 (5.4); 2.5096 (82.9); 2.5050 (183.7); 2.5003 (258.5); 2.4957 (178.9); 2.4911 (78.6); 2.4677 (1.0); 2.4553 (1.5); 2.4505 (1.8); 2.4459 (1.3); 2.3365 (0.5); 2.3317 (1.1); 2.3271 (1.5); 2.3225 (1.1); 2.0725 (0.5); 0.0080 (3.4); -0.0002 (129.6); -0.0085 (4.1); -0.0501 (2.0); -0.0641 (2.9) I.4-46:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.3583 (2.8); 8.3522 (2.8); 8.2506 (1.7); 8.2440 (1.7); 8.1648 (0.9); 8.1607 (0.9); 8.1440 (1.7); 8.1399 (1.8); 8.1287 (1.5); 8.1241 (2.0); 8.1192 (1.1); 8.1080 (2.8); 8.1039 (2.8); 8.0872 (1.5); 8.0831 (1.4); 7.7290 (3.0); 7.7233 (1.2); 7.7157 (6.6); 7.7111 (2.6); 7.7057 (4.2); 7.7032 (5.6); 7.6977 (3.2); 7.6926 (6.9); 7.6857 (1.8); 7.6799 (5.1); 7.2526 (3.5); 7.2468 (1.2); 7.2409 (5.7); 7.2351 (2.6); 7.2307 (4.9); 7.2236 (2.2); 7.2190 (7.7); 7.2139 (3.6); 7.2114 (2.6); 7.2080 (3.8); 7.2020 (1.8); 7.1960 (6.5); 7.1913 (2.8); 7.1858 (1.9); 7.1821 (1.8); 7.1753 (1.3); 7.1716 (1.4); 7.1655 (2.6); 7.1620 (2.7); 7.1459 (1.3); 7.1424 (1.3); 7.1181 (1.8); 7.1086 (2.2); 7.1038 (3.0); 7.0979 (3.3); 7.0899 (4.4); 7.0733 (1.8); 7.0629 (1.1); 6.9800 (1.2); 6.9757 (1.3); 6.9672 (1.3); 6.9627 (1.6); 6.9552 (1.5); 6.9486 (1.6); 6.9441 (1.5); 6.9413 (1.8); 6.9367 (1.7); 6.9290 (1.2); 6.9228 (1.1); 6.9182 (0.9); 6.9108 (0.5); 5.7544 (13.2); 4.5110 (0.8); 4.4971 (0.8); 4.1218 (1.4); 4.1081 (1.7); 4.0959 (2.0); 4.0911 (1.5); 4.0820 (2.1); 4.0790 (2.6); 4.0719 (3.9); 4.0650 (1.8); 4.0599 (3.4); 4.0485 (1.1); 4.0415 (1.0); 4.0392 (1.0); 4.0212 (0.7); 3.6255 (1.6); 3.6206 (1.6); 3.6058 (0.9); 3.5996 (1.6); 3.5947 (1.7); 3.5800 (2.8); 3.5743 (2.8); 3.5484 (0.7); 3.3698 (0.6); 3.3199 (102.6); 3.2698 (1.2); 2.9679 (1.5); 2.9501 (2.1); 2.9323 (1.5); 2.6081 (1.5); 2.5899 (2.0); 2.5702 (1.5); 2.5528 (0.8); 2.5248 (0.9); 2.5202 (1.4); 2.5115 (20.4); 2.5069 (44.8); 2.5023 (62.8); 2.4977 (44.0); 2.4931 (19.7); 2.4567 (0.6); 2.4522 (0.8); 2.4476 (0.6); 1.9889 (3.0); 1.2466 (0.6); 1.2186 (16.0); 1.2007 (15.7); 1.1932 (1.6); 1.1753 (1.9); 1.1575 (0.9); 1.1092 (9.0); 1.0909 (8.9); 0.8581 (1.1); - 0.0002 (11.1) I.4-47:1H NMR (400.0MHz, d6-DMSO): δ= 9.3011 (0.8); 8.3178 (7.6); 8.3114 (7.8); 8.2233 (1.6); 8.2171 (1.3); 8.1356 (5.6); 7.8979 (3.7); 7.8928 (7.0); 7.8875 (3.6); 7.7586 (2.5); 7.7422 (2.6); 7.5776 (2.2); 7.5567 (2.7); 7.5535 (2.7); 7.5321 (1.3); 7.5107 (1.4); 7.4517 (8.3); 7.4340 (4.2); 7.4302 (9.3); 7.4137 (6.4); 7.3932 (3.5); 7.2236 (2.7); 7.2214 (3.0); 7.2185 (2.7); 7.2013 (2.3); 7.1985 (2.5); 7.1561 (0.8); 7.1414 (0.8); 7.1348 (0.9); 7.0394 (5.5); 7.0330 (5.3); 7.0180 (4.7); 7.0115 (4.9); 5.2979 (3.1); 4.3844 (1.3); 4.1862 (2.4); 4.1701 (2.1); 4.1605 (2.6); 4.1447 (2.1); 3.7295 (1.9); 3.7203 (1.9); 3.7035 (2.0); 3.6955 (1.9); 3.4103 (0.9); 3.3915 (1.2); 3.3734 (3.4); 3.3609 (3.1); 3.3553 (4.0); 3.3460 (3.3); 3.3116 (1178.7); 3.2632 (1.3); 3.0939 (3.3); 3.0773 (3.0); 3.0265 (2.1); 3.0073 (2.3); 2.9838 (2.8); 2.9647 (2.3); 2.6743 (2.8); 2.6698 (3.9); 2.6651 (2.6); 2.5231 (11.9); 2.5184 (17.2); 2.5098 (231.5); 2.5052 (496.6); 2.5006 (688.5); 2.4960 (477.6); 2.4914 (212.7); 2.4522 (2.3); 2.4432 (2.3); 2.4098 (1.7); 2.4008 (2.0); 2.3320 (2.9); 2.3274 (3.8); 2.3227 (2.8); 1.2499 (2.4); 1.2319 (4.8); 1.2136 (2.4); 1.1965 (8.1); 1.1783 (16.0); 1.1601 (7.8); -0.0002 (3.2) I.4-48:1H NMR (400.0MHz, d6-DMSO): δ= 8.3213 (4.4); 8.3149 (4.2); 8.1320 (3.7); 7.7528 (1.8); 7.7361 (1.8); 7.5585 (4.9); 7.5371 (5.5); 7.5109 (0.6); 7.4494 (4.7); 7.4280 (5.0); 7.1955 (4.4); 7.1749 (4.0); 7.0358 (3.2); 7.0294 (3.0); 7.0144 (2.8); 7.0079 (2.7); 4.3756 (1.0); 4.1577 (1.6); 4.1422 (1.7); 4.1321 (2.0); 4.1163 (1.6); 3.6689 (1.6); 3.6610 (1.5); 3.6430 (1.4); 3.6347 (1.4); 3.5060 (1.0); 3.3641 (1.2); 3.3084 (380.4); 3.2744 (3.7); 3.2605 (3.6); 2.9854 (1.9); 2.9659 (1.8); 2.9427 (2.0); 2.9232 (1.9); 2.6739 (2.4); 2.6693 (3.1); 2.6648 (2.4); 2.5094 (170.5); 2.5049 (329.8); 2.5003 (436.0); 2.4957 (306.6); 2.4912 (145.4); 2.4027 (5.7); 2.3933 (5.3); 2.3601 (4.4); 2.3511 (4.2); 2.3318 (4.6); 2.3271 (5.2); 2.3224 (4.3); 2.2803 (16.0); 2.0720 (0.9); 1.2984 (0.7); 1.2585 (1.0); 1.2361 (1.6); 1.1722 (0.7); 0.0080 (1.5); -0.0002 (34.6); -0.0086 (1.4) I.4-49:1H NMR (400.0 MHz, CDCl3): δ= 7.5807 (1.7); 7.5611 (2.3); 7.5184 (3.4); 7.4208 (2.1); 7.4121 (1.2); 7.4023 (2.6); 7.3917 (1.6); 7.3807 (1.8); 7.3241 (1.8); 7.3035 (1.4); 7.2931 (1.0); 7.2875 (1.3); 7.2828 (1.2); 7.2812 (1.2); 7.2804 (1.2); 7.2788 (1.3); 7.2772 (1.7); 7.2756 (2.1); 7.2748 (2.2); 7.2740 (2.4); 7.2732 (2.7); 7.2724 (3.1); 7.2716 (3.4); 7.2709 (3.6); 7.2700 (3.9); 7.2692 (4.3); 7.2685 (5.0); 7.2677 (5.5); 7.2669 (6.2); 7.2661 (7.3); 7.2652 (8.6); 7.2644 (10.9); 7.2636 (13.9); 7.2628 (19.1); 7.2595 (583.5); 7.2555 (7.5); 7.2547 (5.0); 7.2538 (3.8); 7.2530 (3.0); 7.2522 (2.4); 7.2514 (2.1); 7.2506 (1.5); 7.2498 (1.3); 7.2491 (1.0); 7.2482 (0.8); 7.2474 (0.8); 7.2458 (0.7); 7.2450 (0.6); 7.2275 (1.4); 7.2218 (2.3); 7.2164 (2.2); 7.2095 (6.7); 7.1902 (0.6); 6.9955 (3.4); 5.1885 (0.6); 4.2691 (1.1); 4.2483 (0.9); 4.2267 (0.8); 4.2116 (0.6); 4.2015 (0.8); 4.1863 (0.9); 3.2349 (0.6); 3.2174 (0.6); 3.1844 (0.6); 3.1667 (0.6); 3.1063 (0.7); 3.0990 (0.7); 3.0832 (0.7); 3.0752 (0.7); 3.0322 (0.5); 2.1890 (10.0); 2.0439 (1.2); 1.5361 (16.0); 1.2588 (1.2); 0.8819 (1.7); 0.8639 (0.7); 0.1460 (0.6); 0.0112 (1.3); 0.0104 (1.5); 0.0080 (8.1); 0.0064 (3.1); 0.0056 (3.3); 0.0048 (4.2); 0.0039 (5.1); -0.0002 (244.4); -0.0042 (5.1); -0.0050 (3.3); -0.0059 (2.7); -0.0067 (2.3); - 0.0084 (6.9); -0.0146 (0.6); -0.0501 (2.3); -0.1494 (0.7) I.4-50:1H NMR (400.0MHz, d6-DMSO): δ= 9.0282 (1.6); 9.0245 (1.7); 9.0172 (1.7); 8.6478 (0.9); 8.6273 (0.9); 8.0848 (1.6); 8.0626 (5.2); 8.0570 (3.9); 7.9759 (3.3); 7.8752 (1.4); 7.8577 (1.8); 7.7680 (1.6); 7.7480 (2.6); 7.7292 (1.7); 7.7128 (0.9); 7.6308 (0.8); 7.6143 (0.8); 7.1592 (2.4); 7.1389 (2.8); 6.9222 (2.2); 6.9166 (2.2); 6.9020 (1.9); 6.8964 (1.9); 5.7546 (0.6); 4.5690 (0.8); 4.3533 (1.6); 4.3365 (1.7); 4.3290 (2.0); 4.3122 (1.6); 3.8559 (2.9); 3.8449 (3.1); 3.8316 (3.4); 3.8206 (3.7); 3.7582 (4.9); 3.0082 (1.4); 2.9882 (1.6); 2.9660 (1.8); 2.9462 (1.6); 2.6710 (0.6); 2.5242 (2.0); 2.5109 (37.9); 2.5064 (80.4); 2.5018 (111.1); 2.4972 (82.2); 2.4927 (39.8); 2.4558 (2.3); 2.4473 (1.3); 2.4425 (1.9); 2.3334 (0.5); 2.3285 (0.7); 2.3239 (0.5); 2.1988 (16.0); 1.9092 (3.2); 1.2078 (0.6); 1.1897 (1.3); 1.1714 (0.6); -0.0002 (1.0) I.4-51:1H NMR (400.0MHz, d6-DMSO): δ= 8.1600 (1.6); 8.1578 (2.8); 8.1547 (2.9); 8.1527 (2.3); 8.1512 (2.3); 8.0530 (4.5); 8.0474 (4.3); 8.0432 (1.4); 8.0381 (1.4); 8.0363 (1.4); 8.0335 (1.1); 8.0288 (1.4); 8.0229 (1.3); 7.7626 (3.6); 7.6171 (0.5); 7.6105 (6.0); 7.6084 (5.0); 7.6014 (2.7); 7.5980 (3.0); 7.5960 (3.3); 7.5945 (3.0); 7.3303 (1.7); 7.3141 (1.7); 7.1467 (2.3); 7.1453 (2.3); 7.1264 (2.7); 7.1250 (2.7); 6.9209 (2.3); 6.9152 (2.3); 6.9008 (2.0); 6.8950 (1.9); 4.4267 (0.5); 4.4190 (0.7); 4.4100 (0.8); 4.4008 (0.7); 4.3937 (0.6); 4.2053 (1.5); 4.1891 (1.5); 4.1796 (1.9); 4.1636 (1.4); 3.7622 (1.4); 3.7534 (1.3); 3.7365 (1.2); 3.7280 (1.2); 3.3638 (65.6); 3.3134 (1.1); 3.0354 (1.5); 3.0159 (1.6); 2.9927 (1.9); 2.9731 (1.7); 2.6704 (0.6); 2.5239 (1.2); 2.5192 (1.8); 2.5105 (31.4); 2.5059 (69.2); 2.5013 (97.4); 2.4967 (67.9); 2.4921 (30.0); 2.4754 (1.7); 2.4555 (0.8); 2.4509 (1.2); 2.4428 (1.7); 2.4326 (1.4); 2.3281 (0.6); 2.1423 (16.0); 2.0729 (1.7); 1.1795 (0.7); 0.0080 (1.0); -0.0002 (34.5); -0.0086 (1.0) I.4-52:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0481 (3.5); 8.0424 (3.5); 7.9171 (3.8); 7.9117 (1.6); 7.8999 (2.0); 7.8942 (8.7); 7.8894 (1.5); 7.8655 (1.5); 7.8606 (8.7); 7.8549 (1.8); 7.8432 (1.4); 7.8378 (3.8); 7.7401 (3.6); 7.3094 (1.8); 7.2930 (1.7); 7.1448 (2.4); 7.1434 (2.3); 7.1246 (2.8); 7.1231 (2.8); 6.9202 (2.3); 6.9146 (2.3); 6.9002 (1.9); 6.8945 (1.9); 4.4279 (0.5); 4.4197 (0.7); 4.4113 (0.9); 4.4034 (0.8); 4.3948 (0.6); 4.2122 (1.5); 4.1960 (1.5); 4.1865 (1.9); 4.1704 (1.4); 3.7614 (1.3); 3.7531 (1.3); 3.7357 (1.2); 3.7272 (1.1); 3.3114 (70.1); 3.0520 (1.4); 3.0325 (1.6); 3.0092 (1.8); 2.9897 (1.6); 2.6698 (0.6); 2.5234 (1.4); 2.5186 (2.2); 2.5100 (34.3); 2.5054 (75.7); 2.5008 (106.7); 2.4961 (74.4); 2.4915 (34.3); 2.4593 (1.6); 2.4497 (1.8); 2.3275 (0.6); 2.1362 (16.0); 2.0728 (1.2); 0.0080 (1.4); 0.0048 (0.5); -0.0002 (48.5); -0.0085 (1.4) I.4-53:1H NMR (400.0MHz, d6-DMSO): δ= 9.0202 (1.2); 9.0163 (1.3); 9.0094 (1.2); 9.0055 (1.2); 8.6258 (0.7); 8.6071 (0.6); 8.3850 (1.6); 8.3792 (1.5); 8.1303 (0.8); 8.1262 (0.9); 8.1095 (1.6); 8.1054 (1.6); 8.0888 (1.0); 8.0846 (0.9); 8.0729 (1.2); 8.0545 (1.3); 7.8544 (1.0); 7.8380 (1.4); 7.7594 (1.3); 7.7396 (1.7); 7.7297 (0.8); 7.7200 (1.4); 7.7087 (0.7); 7.6980 (0.6); 7.3997 (0.8); 7.3839 (0.7); 7.2175 (1.0); 7.2139 (1.0); 7.1970 (1.1); 7.1934 (1.1); 7.1881 (0.9); 7.1846 (1.0); 7.1678 (1.1); 7.1642 (1.2); 7.1105 (0.8); 7.0915 (1.4); 7.0718 (0.8); 6.9765 (0.7); 6.9723 (0.7); 6.9638 (0.8); 6.9594 (0.9); 6.9537 (0.7); 6.9451 (0.8); 6.9407 (0.8); 5.7549 (16.0); 4.5910 (0.6); 4.5751 (0.6); 4.3492 (1.4); 4.3323 (1.4); 4.3248 (1.8); 4.3079 (1.3); 3.8451 (3.9); 3.8339 (4.2); 3.8207 (4.3); 3.8098 (4.1); 3.1073 (0.8); 3.0952 (0.8); 3.0890 (2.6); 3.0769 (2.6); 3.0707 (2.6); 3.0587 (2.6); 3.0526 (0.9); 3.0405 (0.8); 2.9979 (1.3); 2.9780 (1.4); 2.9559 (1.6); 2.9361 (1.4); 2.6708 (0.7); 2.5518 (0.7); 2.5243 (1.6); 2.5196 (2.5); 2.5110 (37.4); 2.5064 (82.4); 2.5017 (116.7); 2.4971 (81.8); 2.4925 (36.4); 2.4708 (1.8); 2.4610 (0.6); 2.4562 (1.0); 2.4517 (1.2); 2.4472 (1.1); 2.4422 (1.5); 2.4288 (1.1); 2.3285 (0.7); 2.3239 (0.5); 2.0734 (9.7); 1.2073 (5.0); 1.1891 (10.8); 1.1708 (5.0); 0.0081 (1.8); 0.0049 (0.5); -0.0002 (68.8); -0.0086 (2.0) I.4-54:1H NMR (400.0MHz, d6-DMSO): δ= 8.9897 (1.1); 8.9856 (1.2); 8.9791 (1.2); 8.9749 (1.1); 8.5619 (0.6); 8.5423 (0.6); 8.1743 (1.6); 8.1705 (1.6); 8.1535 (1.7); 8.1497 (1.6); 8.0996 (2.4); 8.0434 (1.0); 8.0264 (1.1); 7.8288 (1.0); 7.8106 (1.3); 7.7618 (0.9); 7.7443 (0.9); 7.7331 (1.3); 7.7130 (1.6); 7.6941 (0.9); 7.6866 (0.8); 7.6757 (0.7); 7.6657 (0.7); 7.6547 (0.7); 7.4276 (1.8); 7.4240 (1.8); 7.4075 (1.9); 7.4039 (1.9); 7.2715 (0.8); 7.2679 (0.8); 7.2529 (1.1); 7.2501 (1.3); 7.2323 (0.9); 7.2286 (0.9); 7.1928 (0.8); 7.1891 (0.9); 7.1730 (0.9); 7.1692 (0.9); 7.0446 (0.5); 7.0246 (0.7); 7.0208 (0.6); 7.0064 (0.7); 7.0027 (0.6); 6.9924 (1.2); 6.9884 (1.3); 6.9739 (1.4); 6.9724 (1.4); 6.9700 (1.3); 6.9684 (1.4); 6.9540 (1.1); 6.9500 (1.1); 6.8197 (0.8); 6.8158 (0.8); 6.7998 (0.6); 6.7956 (0.7); 6.5557 (0.6); 4.5556 (0.5); 4.3635 (1.2); 4.3468 (1.2); 4.3390 (1.5); 4.3223 (1.1); 4.0560 (0.8); 4.0381 (2.4); 4.0203 (2.4); 4.0025 (0.9); 3.8530 (1.5); 3.8424 (1.5); 3.8286 (1.6); 3.8177 (1.6); 3.6332 (6.3); 3.0977 (0.9); 3.0857 (0.9); 3.0795 (0.9); 3.0675 (0.8); 3.0101 (1.1); 2.9903 (1.2); 2.9682 (1.4); 2.9483 (1.2); 2.6748 (1.0); 2.6702 (1.5); 2.6654 (1.0); 2.5513 (1.6); 2.5468 (1.4); 2.5236 (3.9); 2.5189 (5.6); 2.5103 (80.4); 2.5056 (176.6); 2.5010 (248.4); 2.4964 (172.6); 2.4918 (76.0); 2.4722 (1.9); 2.4597 (2.3); 2.4557 (2.6); 2.4510 (3.4); 2.4464 (2.6); 2.4416 (1.4); 2.4303 (1.2); 2.4171 (1.0); 2.4008 (0.6); 2.3324 (1.2); 2.3278 (1.6); 2.3232 (1.1); 2.0728 (1.4); 1.9880 (10.9); 1.9084 (16.0); 1.2028 (1.6); 1.1923 (3.2); 1.1846 (3.4); 1.1745 (6.7); 1.1663 (1.7); 1.1567 (3.2); 0.0080 (3.4); 0.0063 (0.8); 0.0055 (0.8); 0.0046 (1.0); 0.0038 (1.4); -0.0002 (127.5); -0.0027 (5.9); -0.0043 (2.5); - 0.0052 (1.8); -0.0060 (1.5); -0.0068 (1.3); -0.0085 (3.9); -0.0502 (1.2) I.4-55:1H NMR (400.0MHz, d6-DMSO): δ= 9.0260 (2.1); 8.1623 (10.4); 8.1585 (10.7); 8.1415 (11.6); 8.1377 (10.9); 8.0802 (1.7); 8.0760 (1.6); 8.0591 (1.6); 8.0554 (1.7); 7.9792 (16.0); 7.6227 (7.6); 7.6061 (7.6); 7.5301 (1.4); 7.5229 (2.3); 7.5115 (11.7); 7.5057 (13.1); 7.4859 (13.6); 7.4803 (11.6); 7.4687 (1.9); 7.4617 (2.8); 7.4580 (2.1); 7.4113 (11.7); 7.4077 (12.4); 7.3913 (12.7); 7.3876 (12.8); 7.3271 (0.8); 7.3050 (1.3); 7.2881 (0.9); 7.2690 (5.2); 7.2653 (5.1); 7.2503 (7.1); 7.2474 (8.7); 7.2298 (5.8); 7.2260 (5.4); 7.1767 (0.7); 7.1733 (0.8); 7.1570 (0.8); 7.1536 (0.7); 7.0849 (1.3); 7.0809 (1.3); 7.0609 (1.5); 7.0463 (1.2); 7.0419 (3.2); 7.0358 (4.6); 7.0298 (2.6); 7.0184 (5.5); 7.0126 (9.3); 7.0069 (4.8); 6.9953 (3.1); 6.9875 (10.2); 6.9835 (11.0); 6.9689 (9.2); 6.9674 (8.8); 6.9650 (9.0); 6.9635 (8.9); 6.9490 (7.3); 6.9450 (6.9); 6.7932 (0.8); 6.7895 (0.8); 6.7692 (0.8); 6.5454 (0.6); 6.5257 (0.6); 5.7538 (1.6); 4.4262 (1.4); 4.4172 (2.4); 4.4102 (3.3); 4.4012 (3.7); 4.3921 (3.5); 4.3841 (2.6); 4.3747 (1.6); 4.3662 (0.9); 4.1614 (7.0); 4.1452 (7.3); 4.1354 (8.8); 4.1194 (6.7); 3.7257 (6.2); 3.7173 (6.0); 3.6998 (5.7); 3.6915 (5.5); 3.3963 (3.1); 3.3480 (256.4); 3.2975 (4.3); 3.1280 (0.9); 3.1159 (0.9); 3.1098 (2.6); 3.0978 (2.4); 3.0916 (2.6); 3.0795 (2.5); 3.0613 (0.9); 3.0443 (7.2); 3.0247 (7.9); 3.0014 (9.1); 2.9820 (8.0); 2.6749 (2.2); 2.6702 (3.3); 2.6657 (2.2); 2.5513 (3.2); 2.5237 (7.1); 2.5190 (10.2); 2.5104 (165.9); 2.5058 (365.7); 2.5011 (514.8); 2.4965 (359.2); 2.4919 (158.6); 2.4769 (9.0); 2.4671 (8.5); 2.4558 (5.2); 2.4512 (6.5); 2.4468 (4.9); 2.4341 (6.7); 2.4241 (6.5); 2.3326 (2.5); 2.3280 (3.2); 2.3233 (2.3); 2.0729 (0.7); 1.9881 (0.9); 1.9086 (0.8); 1.1975 (4.9); 1.1794 (10.4); 1.1612 (4.9); 0.8583 (0.7); 0.8339 (0.5); 0.0080 (2.7); -0.0002 (91.5); -0.0085 (2.6); -0.0501 (0.6) I.4-56:1H NMR (400.0MHz, d6-DMSO): δ= 8.9698 (2.1); 8.9657 (2.3); 8.9594 (2.2); 8.9550 (2.1); 8.5855 (1.8); 8.5146 (1.2); 8.4958 (1.3); 8.0356 (1.0); 8.0255 (2.2); 8.0214 (2.3); 8.0113 (1.2); 8.0048 (2.4); 8.0012 (2.3); 7.9909 (1.0); 7.9828 (0.9); 7.7965 (1.6); 7.7932 (1.7); 7.7782 (2.5); 7.7748 (2.3); 7.7108 (2.4); 7.6911 (2.8); 7.6720 (1.6); 7.6553 (1.6); 7.6447 (1.5); 7.6344 (1.5); 7.6235 (1.4); 7.4327 (1.7); 7.4154 (1.6); 7.2782 (1.0); 7.2652 (1.1); 7.2556 (1.1); 7.2507 (1.1); 7.2424 (1.1); 7.2377 (1.0); 7.2281 (1.1); 7.2149 (1.0); 6.7850 (0.7); 6.7763 (0.9); 6.7652 (0.9); 6.7558 (1.2); 6.7479 (0.7); 6.7336 (0.9); 4.5550 (0.9); 4.3655 (1.8); 4.3488 (1.8); 4.3408 (2.4); 4.3242 (1.7); 4.0561 (0.7); 4.0381 (2.0); 4.0204 (2.0); 4.0026 (0.8); 3.8438 (2.2); 3.8328 (2.4); 3.8187 (2.4); 3.8082 (2.5); 3.7188 (2.9); 3.1033 (0.8); 3.0913 (0.7); 3.0852 (0.7); 3.0731 (0.8); 3.0016 (1.7); 2.9818 (1.8); 2.9595 (2.1); 2.9397 (1.9); 2.6744 (1.4); 2.6697 (1.9); 2.6651 (1.4); 2.5233 (4.7); 2.5186 (7.0); 2.5099 (109.9); 2.5053 (240.8); 2.5007 (337.6); 2.4961 (235.8); 2.4915 (104.4); 2.4651 (2.5); 2.4512 (3.2); 2.4460 (1.9); 2.4228 (1.7); 2.4105 (2.0); 2.3322 (1.6); 2.3274 (2.1); 2.3230 (1.5); 1.9879 (8.7); 1.9083 (16.0); 1.2000 (1.4); 1.1923 (2.5); 1.1819 (3.0); 1.1746 (5.2); 1.1638 (1.4); 1.1568 (2.5); 0.0080 (2.6); -0.0002 (100.8); -0.0085 (3.0); -0.0501 (0.6) I.4-57:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4557 (3.2); 8.0108 (1.9); 8.0028 (1.9); 7.9946 (1.8); 7.9865 (1.9); 7.9827 (2.0); 7.9745 (1.8); 7.9663 (1.8); 7.9582 (1.7); 7.5018 (5.0); 7.4961 (5.6); 7.4763 (5.6); 7.4707 (4.5); 7.2935 (3.4); 7.2766 (3.4); 7.2617 (1.9); 7.2488 (2.0); 7.2392 (2.0); 7.2342 (2.0); 7.2260 (2.1); 7.2212 (2.0); 7.2115 (1.9); 7.1986 (1.8); 7.0404 (1.2); 7.0348 (2.0); 7.0290 (1.0); 7.0174 (2.3); 7.0116 (3.9); 7.0058 (1.8); 6.9943 (1.3); 6.9884 (1.9); 6.7832 (1.2); 6.7741 (1.9); 6.7633 (1.6); 6.7541 (2.2); 6.7459 (1.4); 6.7320 (1.6); 6.7232 (0.8); 4.4072 (1.8); 4.3980 (1.6); 4.1563 (3.0); 4.1397 (3.2); 4.1305 (3.8); 4.1139 (2.9); 4.0560 (0.8); 4.0382 (2.2); 4.0204 (2.2); 4.0026 (0.6); 3.7204 (2.7); 3.7116 (2.7); 3.6949 (2.5); 3.6858 (2.4); 3.3177 (146.9); 3.2677 (1.2); 3.1139 (0.6); 3.0958 (0.6); 3.0840 (0.6); 3.0295 (3.2); 3.0098 (3.4); 2.9867 (3.8); 2.9670 (3.4); 2.6742 (2.1); 2.6695 (3.0); 2.6649 (2.1); 2.5230 (8.3); 2.5183 (12.4); 2.5097 (167.0); 2.5051 (361.6); 2.5005 (501.6); 2.4958 (348.5); 2.4912 (154.8); 2.4760 (4.8); 2.4554 (2.9); 2.4507 (3.7); 2.4442 (4.0); 2.4329 (2.8); 2.4006 (0.7); 2.3319 (2.3); 2.3272 (3.2); 2.3227 (2.2); 2.0724 (1.3); 1.9878 (10.2); 1.9079 (16.0); 1.2342 (0.6); 1.1924 (3.0); 1.1746 (6.4); 1.1568 (3.1); 0.0080 (3.9); -0.0002 (141.5); - 0.0085 (4.4); -0.0499 (0.8) I.4-58:1H NMR (400.0MHz, d6-DMSO): δ= 8.5964 (1.2); 8.4671 (0.8); 8.0371 (0.5); 8.0289 (1.1); 8.0208 (1.3); 8.0127 (0.9); 8.0045 (0.8); 8.0004 (1.2); 7.9923 (1.0); 7.9842 (0.7); 7.9760 (0.6); 7.7237 (1.7); 7.7177 (0.7); 7.7118 (3.2); 7.7064 (1.4); 7.7004 (4.5); 7.6945 (1.7); 7.6893 (3.7); 7.6831 (0.8); 7.6772 (2.6); 7.2741 (0.7); 7.2611 (1.0); 7.2524 (2.6); 7.2465 (1.6); 7.2419 (3.6); 7.2296 (3.1); 7.2201 (6.2); 7.2145 (2.2); 7.2078 (2.7); 7.1971 (3.4); 6.7891 (0.5); 6.7802 (0.7); 6.7670 (0.7); 6.7584 (1.2); 6.7499 (0.8); 6.7383 (1.1); 6.7301 (0.7); 4.1225 (0.7); 4.1089 (0.8); 4.0964 (1.3); 4.0825 (1.7); 4.0747 (2.0); 4.0624 (1.8); 4.0523 (0.6); 4.0442 (0.5); 3.6294 (0.8); 3.6247 (0.8); 3.6032 (0.8); 3.5987 (0.8); 3.5818 (1.4); 3.5760 (1.4); 3.3223 (86.8); 3.2727 (0.7); 3.1267 (0.8); 3.1146 (0.8); 3.1085 (2.5); 3.0964 (2.5); 3.0902 (2.6); 3.0782 (2.5); 3.0720 (0.8); 3.0600 (0.7); 2.9770 (0.8); 2.9590 (1.0); 2.9412 (0.8); 2.6745 (0.9); 2.6699 (1.3); 2.6653 (1.0); 2.6096 (0.8); 2.5912 (1.0); 2.5719 (0.7); 2.5344 (0.6); 2.5297 (0.6); 2.5234 (3.0); 2.5187 (4.6); 2.5100 (72.6); 2.5054 (160.5); 2.5008 (225.5); 2.4962 (156.9); 2.4916 (68.9); 2.4695 (0.7); 2.4602 (0.6); 2.4554 (1.1); 2.4508 (1.5); 2.4463 (1.1); 2.3322 (1.0); 2.3276 (1.4); 2.3230 (1.0); 2.0727 (0.8); 1.9083 (16.0); 1.2153 (8.4); 1.1976 (12.2); 1.1799 (10.4); 1.1617 (4.7); 1.1027 (4.6); 1.0844 (4.6); -0.0002 (12.7) I.4-59:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.6164 (1.1); 7.6119 (1.1); 7.6035 (1.4); 7.5985 (2.1); 7.5937 (1.5); 7.5908 (1.5); 7.5855 (1.8); 7.5807 (1.7); 7.5774 (2.0); 7.5725 (1.4); 7.5644 (1.4); 7.5597 (1.3); 7.5218 (1.6); 7.5176 (2.0); 7.5018 (4.9); 7.4982 (5.3); 7.4805 (4.1); 7.4773 (4.0); 7.4728 (2.4); 7.4652 (2.9); 7.4607 (2.5); 7.4549 (1.7); 7.4517 (1.7); 7.4472 (2.5); 7.4424 (2.4); 7.4136 (3.1); 7.4103 (2.9); 7.3950 (2.9); 7.3754 (1.6); 7.3720 (1.6); 7.3654 (1.0); 7.3624 (1.5); 7.3581 (1.4); 7.3524 (1.1); 7.3424 (3.5); 7.3380 (2.7); 7.3316 (1.9); 7.3272 (1.7); 7.3220 (1.0); 7.3160 (2.2); 7.3118 (2.8); 7.2955 (1.2); 7.2906 (0.8); 7.2846 (2.6); 7.2792 (1.5); 7.2675 (2.5); 7.2650 (2.2); 7.2624 (1.9); 7.2480 (2.0); 7.2428 (1.2); 5.7537 (16.0); 5.1190 (0.9); 5.0977 (1.3); 5.0739 (0.9); 4.2810 (1.3); 4.2553 (1.9); 4.2344 (1.5); 4.0036 (1.8); 3.9958 (1.7); 3.9773 (1.5); 3.9699 (1.4); 3.3785 (8.6); 3.0723 (1.8); 3.0477 (2.1); 3.0280 (2.9); 3.0034 (2.4); 2.8529 (2.0); 2.8439 (1.9); 2.8085 (1.3); 2.7998 (1.4); 2.6739 (1.2); 2.6693 (1.8); 2.6645 (1.4); 2.6602 (0.6); 2.5501 (0.5); 2.5228 (3.9); 2.5181 (5.7); 2.5094 (102.3); 2.5048 (227.3); 2.5002 (322.9); 2.4955 (224.9); 2.4909 (99.5); 2.4651 (1.2); 2.4595 (1.3); 2.4548 (1.7); 2.4502 (2.1); 2.4455 (1.6); 2.4003 (0.6); 2.3363 (0.9); 2.3315 (1.5); 2.3269 (2.1); 2.3223 (1.5); 0.1460 (0.5); 0.0081 (5.1); 0.0041 (0.9); -0.0002 (221.5); -0.0086 (6.8); -0.0300 (0.6); -0.0501 (1.0); -0.1496 (0.6) I.4-60:1H NMR (400.0MHz, d6-DMSO): δ= 7.7261 (1.8); 7.7220 (2.9); 7.7188 (2.6); 7.7086 (1.9); 7.7055 (2.5); 7.7034 (3.8); 7.7004 (2.3); 7.6166 (1.0); 7.6066 (1.6); 7.6024 (1.7); 7.5897 (3.0); 7.5830 (3.4); 7.5714 (3.8); 7.5650 (3.3); 7.5539 (3.2); 7.5520 (3.4); 7.5499 (3.7); 7.5478 (3.5); 7.5361 (2.7); 7.5342 (2.9); 7.5291 (6.1); 7.5241 (3.9); 7.5136 (2.7); 7.5101 (3.5); 7.5044 (2.0); 7.4941 (2.4); 7.4903 (1.9); 7.4745 (1.0); 7.4704 (1.2); 7.3644 (1.4); 7.3438 (4.5); 7.3388 (3.2); 7.3311 (1.6); 7.3168 (2.3); 7.3126 (2.9); 7.2958 (1.2); 7.2863 (1.6); 7.2826 (1.9); 7.2660 (2.4); 7.2496 (1.1); 7.2464 (1.2); 5.7537 (16.0); 5.1308 (0.9); 5.1094 (1.3); 5.0853 (1.0); 4.2966 (1.5); 4.2711 (2.0); 4.2500 (1.6); 4.0603 (1.4); 4.0525 (1.2); 4.0337 (1.1); 4.0259 (1.1); 3.9648 (1.3); 3.9572 (1.3); 3.9387 (1.1); 3.9309 (1.1); 3.3105 (122.6); 3.2604 (0.8); 3.0927 (1.9); 3.0823 (1.8); 3.0681 (1.8); 3.0577 (1.6); 3.0484 (1.8); 3.0377 (1.9); 3.0238 (1.4); 3.0131 (1.5); 2.9080 (1.5); 2.8994 (1.6); 2.8639 (1.0); 2.8550 (1.0); 2.8177 (1.5); 2.8089 (1.4); 2.7736 (1.0); 2.7645 (1.2); 2.6739 (2.0); 2.6693 (2.7); 2.6646 (1.9); 2.5228 (7.2); 2.5181 (10.4); 2.5094 (150.0); 2.5048 (327.1); 2.5002 (459.8); 2.4955 (318.0); 2.4909 (138.3); 2.4549 (2.0); 2.4503 (2.6); 2.4456 (1.8); 2.4005 (0.7); 2.3317 (2.0); 2.3270 (2.8); 2.3223 (2.0); 1.2338 (0.7); 1.1872 (2.8); 1.1692 (5.2); 1.1513 (2.7); 0.1464 (0.6); 0.0081 (6.3); - 0.0002 (244.3); -0.0086 (7.1); -0.0500 (1.2); -0.1499 (0.8) I.4-61:1H NMR (400.0MHz, d6-DMSO): δ= 7.7245 (2.7); 7.7208 (2.6); 7.7137 (1.2); 7.7100 (1.7); 7.7064 (3.7); 7.7036 (3.0); 7.7017 (2.4); 7.6969 (1.0); 7.6945 (1.6); 7.6920 (1.0); 7.6826 (2.4); 7.6797 (3.2); 7.6752 (3.0); 7.6724 (3.3); 7.6675 (2.2); 7.6605 (3.6); 7.6579 (3.6); 7.6532 (4.0); 7.6505 (4.3); 7.6282 (2.0); 7.6254 (1.7); 7.6168 (1.0); 7.6082 (1.9); 7.5997 (1.2); 7.5939 (2.2); 7.5916 (2.0); 7.5848 (3.6); 7.5810 (1.4); 7.5762 (2.4); 7.5710 (3.0); 7.5656 (3.8); 7.5577 (3.9); 7.5555 (4.0); 7.5535 (4.2); 7.5519 (4.6); 7.5486 (3.4); 7.5468 (3.1); 7.5413 (4.5); 7.5381 (3.7); 7.5276 (1.3); 7.5239 (2.6); 7.5209 (3.2); 7.5109 (2.0); 7.5085 (1.8); 7.5050 (1.0); 7.4991 (0.6); 7.4238 (2.6); 7.4216 (2.9); 7.4112 (1.6); 7.4052 (3.9); 7.4028 (4.7); 7.3929 (1.6); 7.3890 (1.7); 7.3837 (3.8); 7.3814 (2.7); 7.3713 (1.5); 7.3660 (1.9); 7.3445 (1.5); 7.1991 (0.6); 7.1877 (1.6); 7.1855 (1.6); 7.1692 (2.6); 7.1673 (2.7); 7.1507 (1.2); 7.1484 (1.2); 7.1391 (0.8); 7.1208 (1.4); 7.1023 (0.7); 5.7536 (16.0); 5.1207 (0.6); 5.1001 (0.9); 5.0807 (0.6); 4.7360 (0.7); 4.7195 (1.9); 4.7014 (1.7); 4.6804 (1.0); 4.3925 (0.5); 4.3736 (0.6); 4.3633 (1.0); 4.3522 (0.6); 4.3453 (0.5); 4.2238 (0.9); 4.1980 (1.6); 4.1924 (1.9); 4.1838 (1.8); 4.1765 (1.4); 4.1719 (1.8); 4.1666 (1.8); 4.1045 (1.2); 4.0890 (1.2); 4.0790 (0.8); 4.0634 (0.8); 4.0123 (1.3); 3.9841 (1.1); 3.3096 (79.7); 3.2600 (0.7); 3.2391 (1.0); 3.2330 (1.3); 3.2149 (2.1); 3.1970 (1.5); 3.1743 (1.3); 3.1560 (2.0); 3.1378 (1.3); 3.1008 (0.7); 3.0824 (0.6); 2.6739 (1.2); 2.6692 (1.6); 2.6645 (1.1); 2.5227 (3.8); 2.5180 (5.6); 2.5093 (83.8); 2.5048 (183.4); 2.5001 (258.6); 2.4955 (178.7); 2.4909 (77.9); 2.4669 (0.8); 2.4550 (1.3); 2.4505 (1.6); 2.4460 (1.2); 2.3363 (0.6); 2.3317 (1.1); 2.3269 (1.7); 2.3223 (1.1); 2.0953 (0.6); 1.2985 (12.8); 1.2803 (12.4); 1.2348 (0.5); 1.1916 (1.8); 1.1735 (3.5); 1.1554 (1.7); 1.1081 (3.6); 1.0928 (3.5); 1.0897 (4.0); 1.0745 (2.9); 0.0081 (4.7); 0.0057 (1.3); 0.0049 (1.5); 0.0040 (2.0); -0.0002 (169.9); -0.0057 (1.7); -0.0066 (1.4); -0.0086 (4.7); - 0.0495 (0.7) I.4-62:1H NMR (400.0MHz, d6-DMSO): δ= 7.7424 (0.5); 7.7161 (0.5); 7.7081 (4.8); 7.7025 (1.4); 7.6909 (1.6); 7.6852 (6.0); 7.6773 (0.6); 7.6060 (0.5); 7.6013 (0.6); 7.5931 (0.6); 7.5880 (1.0); 7.5850 (0.7); 7.5831 (0.8); 7.5803 (0.7); 7.5752 (0.7); 7.5702 (0.8); 7.5669 (1.0); 7.5620 (0.7); 7.5542 (0.6); 7.5492 (0.6); 7.5212 (0.7); 7.4985 (0.8); 7.4878 (1.0); 7.4846 (1.2); 7.4718 (0.9); 7.4638 (7.3); 7.4584 (2.7); 7.4466 (1.8); 7.4412 (7.0); 7.4332 (0.6); 7.4241 (1.2); 7.4191 (1.0); 7.3991 (1.6); 7.3958 (1.4); 7.3809 (1.3); 7.3779 (1.3); 7.3612 (0.6); 7.3577 (0.6); 5.7537 (16.0); 5.0406 (0.6); 5.0374 (0.6); 4.3596 (0.9); 4.3390 (1.1); 4.3322 (1.3); 4.3117 (1.0); 4.0592 (0.8); 4.0528 (0.8); 4.0316 (0.7); 4.0256 (0.7); 3.4163 (2.1); 3.1549 (0.9); 3.1302 (1.1); 3.1102 (1.4); 3.0855 (1.2); 2.9000 (1.0); 2.8925 (0.9); 2.8554 (0.7); 2.8482 (0.7); 2.6693 (0.6); 2.5228 (1.3); 2.5181 (2.0); 2.5094 (28.9); 2.5048 (63.4); 2.5002 (89.4); 2.4956 (61.6); 2.4910 (26.7); 2.4502 (0.5); 2.3270 (0.5); 1.1777 (0.7); 0.0080 (1.5); -0.0002 (61.9); -0.0060 (0.5); -0.0085 (1.8) I.4-63:1H NMR (400.0MHz, d6-DMSO): δ= 8.1391 (8.0); 8.1359 (9.6); 8.1327 (8.3); 8.1305 (5.8); 8.0396 (2.3); 8.0340 (2.3); 8.0282 (3.2); 8.0220 (3.3); 8.0158 (3.2); 8.0138 (3.8); 8.0100 (3.2); 8.0017 (2.6); 7.9960 (2.3); 7.9865 (0.5); 7.7700 (0.6); 7.7187 (3.6); 7.7146 (5.1); 7.7112 (3.8); 7.7068 (5.4); 7.7002 (4.1); 7.6987 (4.4); 7.6947 (5.3); 7.6916 (4.3); 7.6881 (4.7); 7.6457 (1.0); 7.6265 (16.0); 7.6244 (14.6); 7.6216 (6.7); 7.6172 (7.4); 7.6143 (13.7); 7.6122 (14.7); 7.5984 (3.9); 7.5933 (5.3); 7.5800 (9.4); 7.5750 (8.7); 7.5613 (8.1); 7.5555 (9.6); 7.5522 (3.6); 7.5438 (5.5); 7.5395 (6.5); 7.5374 (5.4); 7.5333 (5.7); 7.5254 (3.1); 7.5211 (2.7); 7.5190 (3.5); 7.5150 (2.9); 7.5027 (10.7); 7.4982 (8.2); 7.4965 (8.0); 7.4840 (5.7); 7.4785 (4.2); 5.7537 (8.8); 5.0951 (1.5); 5.0896 (1.6); 5.0706 (3.0); 5.0504 (1.8); 4.4234 (2.1); 4.4154 (2.2); 4.4034 (2.6); 4.3953 (5.1); 4.3876 (3.2); 4.3757 (2.4); 4.3674 (2.3); 4.1889 (2.5); 4.1829 (2.6); 4.1613 (2.2); 4.1553 (2.0); 4.0692 (2.4); 4.0634 (2.4); 4.0413 (2.2); 4.0356 (2.1); 3.3107 (139.9); 3.2614 (0.9); 3.2255 (2.2); 3.2073 (2.2); 3.2010 (2.7); 3.1808 (3.8); 3.1624 (3.5); 3.1562 (2.9); 3.1383 (2.8); 3.1144 (0.9); 3.1025 (1.0); 3.0959 (0.8); 3.0845 (0.9); 3.0027 (3.0); 2.9956 (2.9); 2.9579 (2.0); 2.9510 (2.1); 2.8910 (2.8); 2.8842 (2.8); 2.8463 (2.2); 2.8395 (2.2); 2.6740 (2.0); 2.6694 (2.8); 2.6648 (2.0); 2.6601 (0.9); 2.5504 (0.6); 2.5229 (6.2); 2.5182 (9.4); 2.5095 (153.5); 2.5049 (338.6); 2.5003 (478.6); 2.4957 (332.0); 2.4910 (145.7); 2.4552 (2.6); 2.4504 (3.1); 2.4459 (2.2); 2.3317 (2.2); 2.3271 (3.0); 2.3224 (2.1); 2.0725 (1.1); 1.2346 (0.7); 1.1939 (2.6); 1.1757 (5.2); 1.1575 (2.4); 0.1460 (0.8); 0.0126 (0.6); 0.0119 (0.8); 0.0110 (1.0); 0.0103 (1.1); 0.0080 (9.1); 0.0063 (2.5); 0.0055 (2.7); 0.0047 (3.2); 0.0039 (4.1); 0.0022 (11.8); -0.0002 (312.7); -0.0027 (14.3); -0.0035 (9.1); -0.0043 (5.2); -0.0052 (3.7); -0.0060 (3.0); -0.0068 (2.7); -0.0085 (9.0); -0.0107 (1.4); -0.0115 (1.3); -0.0124 (1.1); -0.0132 (1.0); -0.0139 (1.0); -0.0148 (0.9); -0.0155 (0.8); -0.0164 (0.8); -0.0171 (0.6); -0.0179 (0.6); -0.0187 (0.7); -0.0203 (0.6); -0.0211 (0.5); -0.0330 (0.7); - 0.0500 (1.1); -0.1496 (0.9) I.4-64:1H NMR (400.0MHz, d6-DMSO): δ= 9.7639 (2.7); 8.5660 (1.5); 7.6080 (2.4); 7.6033 (2.9); 7.5951 (2.7); 7.5899 (5.7); 7.5851 (4.0); 7.5823 (3.7); 7.5773 (3.4); 7.5722 (4.1); 7.5689 (6.1); 7.5640 (3.8); 7.5563 (3.4); 7.5513 (3.4); 7.4964 (2.7); 7.4898 (7.7); 7.4850 (12.4); 7.4791 (12.4); 7.4687 (5.9); 7.4642 (11.2); 7.4595 (16.0); 7.4537 (13.5); 7.4429 (6.6); 7.4390 (9.5); 7.4341 (6.9); 7.4211 (7.1); 7.4158 (6.0); 7.4007 (10.1); 7.3975 (8.7); 7.3827 (7.9); 7.3795 (7.8); 7.3629 (3.7); 7.3594 (3.6); 7.0539 (2.4); 7.0482 (4.2); 7.0425 (2.1); 7.0308 (5.2); 7.0251 (8.3); 7.0193 (3.9); 7.0079 (2.5); 7.0019 (4.1); 6.9961 (1.9); 5.7537 (3.1); 5.0613 (2.9); 5.0550 (2.1); 5.0409 (4.3); 5.0372 (4.1); 5.0226 (2.1); 5.0165 (2.9); 4.3656 (5.6); 4.3452 (6.5); 4.3376 (7.7); 4.3175 (5.9); 4.0760 (5.0); 4.0708 (4.9); 4.0480 (4.3); 3.3160 (188.2); 3.2660 (1.8); 3.2178 (5.6); 3.1931 (6.5); 3.1727 (8.0); 3.1481 (6.7); 2.9215 (5.4); 2.9150 (5.4); 2.8764 (4.2); 2.8699 (4.1); 2.6740 (3.5); 2.6694 (5.0); 2.6647 (3.4); 2.6602 (1.6); 2.5229 (12.2); 2.5182 (18.1); 2.5095 (260.3); 2.5049 (570.0); 2.5003 (804.0); 2.4956 (554.9); 2.4910 (247.1); 2.4549 (4.4); 2.4502 (5.6); 2.4458 (4.2); 2.3318 (3.6); 2.3271 (4.8); 2.3224 (3.5); 2.0724 (1.8); 1.1762 (1.0); 0.1458 (1.3); 0.0126 (1.0); 0.0118 (1.1); 0.0080 (15.7); 0.0063 (4.1); 0.0055 (4.4); 0.0046 (5.5); 0.0038 (7.4); 0.0022 (21.1); -0.0002 (556.5); -0.0028 (22.8); -0.0035 (14.4); -0.0044 (8.4); -0.0052 (6.3); -0.0060 (5.2); -0.0068 (4.5); -0.0085 (15.9); -0.0108 (2.4); -0.0116 (2.1); -0.0124 (1.9); -0.0132 (1.6); -0.0140 (1.5); -0.0148 (1.4); -0.0156 (1.2); -0.0164 (0.9); -0.0172 (1.0); -0.0180 (0.9); -0.0188 (0.9); -0.0291 (0.9); -0.0503 (2.7); -0.1495 (1.5) I.4-65: 1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0516 (3.6); 8.0459 (3.6); 7.7469 (3.5); 7.5139 (2.5); 7.5082 (2.8); 7.4884 (2.9); 7.4827 (2.4); 7.3064 (1.8); 7.2899 (1.8); 7.1473 (2.3); 7.1458 (2.3); 7.1270 (2.7); 7.1256 (2.7); 7.0415 (0.6); 7.0357 (1.0); 7.0183 (1.2); 7.0126 (2.1); 7.0068 (1.0); 6.9951 (0.7); 6.9894 (1.1); 6.9218 (2.4); 6.9161 (2.3); 6.9016 (2.0); 6.8960 (1.9); 4.4119 (0.5); 4.4041 (0.7); 4.3948 (0.8); 4.3862 (0.8); 4.3782 (0.6); 4.1589 (1.5); 4.1426 (1.6); 4.1330 (1.9); 4.1168 (1.4); 3.7256 (1.3); 3.7171 (1.3); 3.6998 (1.2); 3.6915 (1.2); 3.3159 (263.8); 3.2654 (1.6); 3.0415 (1.5); 3.0219 (1.7); 2.9987 (1.9); 2.9792 (1.7); 2.6746 (0.6); 2.6700 (0.9); 2.6655 (0.6); 2.5235 (1.7); 2.5188 (2.6); 2.5101 (47.1); 2.5055 (104.4); 2.5009 (147.8); 2.4963 (103.2); 2.4916 (45.6); 2.4755 (2.0); 2.4553 (0.8); 2.4506 (1.1); 2.4425 (1.6); 2.4325 (1.4); 2.3323 (0.7); 2.3277 (0.9); 2.3230 (0.7); 2.1402 (16.0); 2.0727 (0.6); 1.1771 (0.8); 0.0081 (1.5); -0.0002 (53.9); -0.0085 (1.5) I.4-66:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.1051 (2.4); 8.0995 (2.4); 8.0591 (3.6); 8.0535 (3.4); 7.8691 (3.6); 7.7495 (2.8); 7.7436 (3.2); 7.7373 (2.9); 7.7317 (1.6); 7.7263 (2.8); 7.7216 (3.7); 7.7141 (2.9); 7.7093 (3.6); 7.7041 (1.8); 7.6984 (3.7); 7.6918 (1.1); 7.6860 (3.5); 7.2549 (2.7); 7.2489 (1.1); 7.2431 (4.2); 7.2372 (2.3); 7.2318 (5.2); 7.2273 (3.4); 7.2213 (6.2); 7.2158 (3.3); 7.2102 (3.7); 7.2044 (2.2); 7.1984 (3.9); 7.1592 (2.4); 7.1375 (4.3); 7.1173 (1.9); 6.9292 (2.4); 6.9236 (2.3); 6.9090 (2.1); 6.9039 (2.6); 6.8997 (1.7); 6.8850 (1.4); 6.8795 (1.4); 4.5174 (0.6); 4.5035 (0.7); 4.1284 (1.0); 4.1149 (1.2); 4.1025 (2.2); 4.0888 (1.3); 4.0841 (2.7); 4.0674 (2.6); 4.0554 (1.2); 4.0380 (0.8); 3.6312 (1.2); 3.6268 (1.1); 3.6007 (1.5); 3.5861 (1.7); 3.5797 (1.8); 3.3113 (250.1); 3.2811 (0.5); 3.2785 (0.7); 3.2618 (1.6); 3.1107 (1.6); 3.0988 (1.7); 3.0925 (1.7); 3.0804 (1.6); 3.0623 (0.5); 2.9801 (1.2); 2.9624 (1.6); 2.9445 (1.1); 2.6743 (1.3); 2.6696 (1.8); 2.6650 (1.3); 2.6165 (1.0); 2.5986 (1.3); 2.5786 (1.1); 2.5231 (3.8); 2.5184 (5.8); 2.5098 (97.6); 2.5052 (215.8); 2.5005 (302.6); 2.4959 (211.6); 2.4913 (94.1); 2.4552 (2.0); 2.4507 (2.4); 2.4461 (1.8); 2.4004 (0.5); 2.3319 (1.4); 2.3273 (1.9); 2.3227 (1.3); 2.2555 (1.6); 2.1703 (16.0); 2.1319 (11.1); 2.0725 (2.5); 1.2243 (11.0); 1.2065 (10.8); 1.1964 (4.3); 1.1782 (8.6); 1.1600 (4.0); 1.1140 (6.9); 1.0957 (6.8); 0.0080 (3.1); 0.0055 (0.8); -0.0002 (116.9); -0.0068 (1.3); -0.0085 (3.5); -0.0499 (0.7) I.4-67:1H NMR (400.0MHz, d6-DMSO): δ= 9.2529 (0.5); 8.1767 (2.9); 8.1726 (3.1); 8.1588 (4.3); 8.1562 (5.3); 8.1520 (3.6); 7.7285 (1.9); 7.7122 (1.9); 7.5637 (0.6); 7.5573 (5.8); 7.5525 (1.8); 7.5409 (1.9); 7.5360 (6.6); 7.5295 (0.7); 7.3449 (0.8); 7.3416 (1.0); 7.3310 (1.4); 7.2920 (2.0); 7.2717 (4.8); 7.2512 (3.7); 7.2244 (4.6); 7.2203 (5.3); 7.2043 (3.1); 7.2002 (3.0); 7.1950 (4.8); 7.1746 (4.3); 7.0247 (0.6); 7.0045 (1.1); 6.9845 (0.9); 6.7524 (0.7); 6.7488 (1.2); 6.7350 (1.3); 6.7315 (1.4); 6.7281 (1.0); 6.7155 (1.1); 6.7119 (0.8); 5.6679 (0.7); 4.3999 (0.6); 4.3922 (0.8); 4.3832 (0.9); 4.3744 (0.8); 4.3658 (0.6); 4.1569 (1.8); 4.1410 (1.9); 4.1312 (2.2); 4.1154 (1.7); 3.6661 (1.6); 3.6581 (1.5); 3.6404 (1.4); 3.6325 (1.4); 3.3147 (96.5); 3.0905 (0.9); 3.0730 (0.9); 2.9805 (1.7); 2.9612 (1.9); 2.9382 (2.1); 2.9188 (1.9); 2.5241 (1.0); 2.5194 (1.5); 2.5108 (19.9); 2.5062 (42.7); 2.5016 (59.1); 2.4970 (40.8); 2.4924 (18.0); 2.4086 (1.6); 2.3989 (1.5); 2.3662 (1.4); 2.3567 (1.4); 2.2805 (16.0); 1.2332 (0.6); 1.2011 (3.3); 1.1829 (6.9); 1.1646 (3.3) I.4-68:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.0261 (0.6); 8.2185 (2.1); 8.2119 (2.0); 8.1713 (0.7); 8.1147 (1.1); 8.1104 (1.1); 8.0939 (2.2); 8.0897 (2.1); 8.0732 (1.2); 8.0690 (1.1); 7.5484 (5.6); 7.5435 (1.8); 7.5318 (2.0); 7.5270 (6.4); 7.2352 (0.5); 7.2151 (0.7); 7.2017 (2.2); 7.1930 (6.0); 7.1764 (3.0); 7.1714 (4.9); 7.1641 (2.0); 7.1471 (1.9); 7.1435 (2.0); 7.1018 (1.0); 7.0828 (1.9); 7.0634 (1.1); 6.9661 (0.9); 6.9617 (0.9); 6.9531 (1.0); 6.9488 (1.2); 6.9414 (0.9); 6.9303 (1.0); 6.9227 (0.6); 6.9142 (0.5); 6.9098 (0.5); 4.3963 (0.6); 4.3884 (0.9); 4.3790 (0.9); 4.3706 (0.9); 4.1415 (1.8); 4.1253 (1.9); 4.1161 (2.2); 4.0999 (1.8); 3.6542 (1.6); 3.6456 (1.6); 3.6287 (1.4); 3.6202 (1.4); 3.3111 (267.5); 3.2612 (0.7); 2.9559 (1.8); 2.9364 (2.0); 2.9137 (2.2); 2.8942 (1.9); 2.6744 (0.7); 2.6697 (1.0); 2.6652 (0.8); 2.5230 (3.1); 2.5183 (4.7); 2.5097 (60.6); 2.5051 (130.2); 2.5005 (180.0); 2.4959 (124.1); 2.4913 (54.8); 2.4062 (1.7); 2.3958 (1.7); 2.3641 (1.5); 2.3534 (1.4); 2.3320 (0.8); 2.3274 (1.1); 2.3227 (0.7); 2.2791 (16.0); 1.9876 (0.8); 1.1922 (1.0); 1.1744 (2.0); 1.1564 (0.9); -0.0002 (1.1) I.4-69:1H NMR (400.0 MHz, CDCl3): δ= 7.5179 (3.2); 7.4518 (5.0); 7.4306 (5.7); 7.3244 (0.6); 7.3123 (0.6); 7.2590 (577.6); 7.2324 (0.8); 7.2168 (1.0); 7.2100 (1.5); 7.1960 (2.0); 7.1709 (4.6); 7.1504 (3.8); 6.9950 (3.3); 6.9848 (3.5); 6.9650 (4.4); 6.9444 (2.3); 5.9592 (1.7); 5.1915 (1.0); 4.6158 (0.9); 4.2085 (2.0); 4.1928 (1.9); 4.1820 (2.4); 4.1663 (2.2); 3.8132 (1.9); 3.8054 (1.7); 3.7870 (1.6); 3.7790 (1.4); 3.0463 (1.7); 3.0264 (1.9); 3.0030 (2.2); 2.9828 (2.0); 2.4950 (1.6); 2.4852 (1.6); 2.4517 (1.4); 2.4421 (1.4); 2.3208 (16.0); 1.5350 (211.8); 1.4859 (0.6); 1.4214 (1.0); 1.4032 (1.8); 1.3849 (0.8); 0.1459 (0.8); 0.0079 (8.3); -0.0002 (221.0); -0.0085 (6.8); -0.1496 (0.8) I.4-70:1H NMR (400.0MHz, d6-DMSO): δ= 7.8196 (1.9); 7.8016 (2.1); 7.6177 (3.3); 7.5239 (0.5); 7.5123 (2.5); 7.5065 (2.8); 7.4867 (2.9); 7.4811 (2.4); 7.1358 (1.8); 7.1246 (2.1); 7.1193 (1.9); 7.1078 (2.6); 7.0904 (1.7); 7.0708 (1.0); 7.0386 (0.6); 7.0328 (1.0); 7.0271 (0.5); 7.0154 (1.2); 7.0096 (2.0); 7.0038 (1.0); 6.9923 (0.6); 6.9864 (1.0); 6.9016 (1.3); 6.8986 (1.3); 6.8831 (2.2); 6.8801 (2.1); 6.8645 (0.9); 6.8615 (0.9); 4.4116 (0.6); 4.4039 (0.8); 4.3948 (0.8); 4.3856 (0.8); 4.3782 (0.6); 4.1520 (1.5); 4.1356 (1.6); 4.1262 (1.9); 4.1099 (1.5); 3.7125 (1.4); 3.7040 (1.4); 3.6868 (1.2); 3.6783 (1.2); 3.3136 (102.1); 3.2631 (0.8); 3.0262 (1.6); 3.0065 (1.7); 2.9834 (2.0); 2.9638 (1.7); 2.6697 (0.7); 2.6650 (0.5); 2.5232 (1.6); 2.5185 (2.5); 2.5098 (41.2); 2.5052 (90.7); 2.5006 (127.1); 2.4960 (89.5); 2.4914 (40.2); 2.4751 (2.0); 2.4551 (1.0); 2.4505 (1.3); 2.4427 (1.7); 2.4323 (1.4); 2.3320 (0.6); 2.3274 (0.8); 2.3227 (0.6); 2.1611 (16.0); 1.1949 (0.8); 1.1766 (1.6); 1.1586 (0.8); 0.0080 (1.7); -0.0002 (62.2); -0.0068 (0.8); -0.0085 (2.0) I.4-71:1H NMR (400.0MHz, d6-DMSO): δ= 8.1645 (8.0); 8.1606 (8.2); 8.1436 (8.9); 8.1397 (8.6); 8.0370 (12.3); 7.6441 (6.1); 7.6280 (5.9); 7.5028 (3.2); 7.4985 (3.8); 7.4830 (6.9); 7.4789 (7.2); 7.4634 (4.1); 7.4592 (4.3); 7.4188 (9.1); 7.4152 (9.4); 7.3988 (10.1); 7.3951 (10.0); 7.3739 (1.0); 7.3645 (1.7); 7.3573 (3.6); 7.3530 (3.6); 7.3470 (2.7); 7.3402 (10.7); 7.3370 (6.7); 7.3344 (7.3); 7.3264 (5.0); 7.3221 (4.4); 7.3127 (5.3); 7.3084 (7.1); 7.2920 (2.6); 7.2874 (1.8); 7.2742 (6.3); 7.2682 (7.5); 7.2645 (4.5); 7.2571 (6.5); 7.2548 (5.9); 7.2500 (8.7); 7.2476 (8.3); 7.2378 (5.3); 7.2323 (3.6); 7.2291 (4.6); 7.2253 (4.2); 6.9886 (6.6); 6.9846 (6.8); 6.9701 (7.0); 6.9686 (6.8); 6.9662 (6.9); 6.9646 (6.8); 6.9501 (5.6); 6.9462 (5.4); 4.4508 (2.0); 4.4436 (2.7); 4.4349 (3.2); 4.4254 (2.7); 4.4188 (2.2); 4.1185 (4.5); 4.1024 (4.5); 4.0947 (5.4); 4.0788 (4.5); 4.0559 (1.2); 4.0381 (3.0); 4.0204 (3.1); 4.0025 (1.1); 3.6109 (5.0); 3.6021 (4.9); 3.5862 (4.7); 3.5772 (4.6); 3.3980 (0.7); 3.3658 (2.5); 3.3165 (697.7); 3.2857 (1.5); 3.2663 (6.6); 3.2159 (1.0); 3.1128 (1.8); 3.1008 (1.9); 3.0946 (2.1); 3.0825 (1.9); 3.0644 (0.6); 2.9360 (6.1); 2.9164 (6.7); 2.8935 (7.6); 2.8740 (6.6); 2.6745 (2.7); 2.6699 (3.8); 2.6652 (2.7); 2.5886 (0.7); 2.5444 (3.6); 2.5234 (10.0); 2.5187 (13.8); 2.5100 (198.0); 2.5054 (436.7); 2.5008 (616.8); 2.4962 (434.7); 2.4916 (196.9); 2.4557 (5.1); 2.4511 (7.1); 2.4465 (5.8); 2.3704 (5.8); 2.3597 (5.7); 2.3277 (8.6); 2.3230 (3.6); 2.3176 (5.8); 2.0727 (2.4); 1.9880 (14.6); 1.9083 (16.0); 1.1954 (3.7); 1.1923 (4.8); 1.1772 (7.7); 1.1746 (9.5); 1.1589 (3.8); 1.1568 (5.1); 0.1462 (0.8); 0.0080 (7.5); 0.0064 (2.0); 0.0055 (2.2); 0.0047 (2.8); -0.0002 (258.2); -0.0067 (4.0); -0.0085 (8.2); - 0.0499 (1.8); -0.1498 (0.8) I.4-72:1H NMR (400.0MHz, d6-DMSO): δ= 8.1972 (3.7); 8.1933 (3.7); 8.1763 (4.0); 8.1724 (3.9); 8.1675 (2.9); 8.1637 (3.1); 8.1467 (3.2); 8.1429 (3.2); 8.0904 (4.7); 8.0344 (5.4); 7.7455 (5.4); 7.7396 (1.8); 7.7332 (6.0); 7.7276 (3.1); 7.7222 (6.3); 7.7180 (5.0); 7.7099 (6.2); 7.7057 (5.0); 7.7004 (2.6); 7.6948 (5.0); 7.6883 (1.5); 7.6824 (4.7); 7.5243 (2.0); 7.5083 (2.0); 7.4937 (2.8); 7.4725 (2.7); 7.4238 (3.5); 7.4202 (3.5); 7.4034 (4.7); 7.4019 (5.2); 7.3986 (5.4); 7.3819 (4.5); 7.3783 (4.7); 7.2733 (1.7); 7.2698 (1.7); 7.2638 (2.4); 7.2598 (2.5); 7.2559 (7.7); 7.2505 (3.8); 7.2431 (8.3); 7.2387 (4.5); 7.2343 (10.1); 7.2211 (8.3); 7.2171 (2.7); 7.2113 (6.0); 7.2042 (1.6); 7.1984 (4.5); 6.9962 (2.5); 6.9922 (2.7); 6.9777 (2.9); 6.9762 (2.8); 6.9737 (5.4); 6.9696 (3.5); 6.9578 (2.6); 6.9551 (3.7); 6.9537 (5.1); 6.9512 (3.3); 6.9497 (3.4); 6.9352 (2.7); 6.9312 (2.6); 5.7535 (1.3); 4.5401 (0.7); 4.5238 (1.4); 4.5096 (1.5); 4.4924 (0.7); 4.1283 (2.4); 4.1147 (2.7); 4.1071 (1.6); 4.1024 (3.3); 4.0888 (5.6); 4.0770 (1.9); 4.0710 (3.2); 4.0563 (1.9); 4.0383 (2.7); 4.0205 (2.2); 4.0026 (0.7); 3.6300 (2.7); 3.6255 (2.8); 3.6040 (2.7); 3.5994 (3.0); 3.5836 (2.4); 3.5772 (2.4); 3.5646 (0.7); 3.4000 (0.8); 3.3657 (2.5); 3.3510 (1.1); 3.3486 (1.4); 3.3169 (717.5); 3.2888 (1.3); 3.2835 (1.0); 3.2667 (5.7); 3.2553 (0.9); 3.2164 (1.0); 3.1983 (0.6); 2.9942 (0.7); 2.9760 (2.7); 2.9581 (3.6); 2.9404 (2.6); 2.9226 (0.6); 2.6747 (1.4); 2.6702 (2.0); 2.6655 (1.5); 2.6028 (1.5); 2.5847 (2.1); 2.5649 (1.4); 2.5505 (1.8); 2.5236 (5.8); 2.5190 (8.2); 2.5103 (108.8); 2.5057 (238.6); 2.5010 (336.1); 2.4964 (232.6); 2.4918 (101.4); 2.4557 (2.6); 2.4511 (3.1); 2.4464 (2.2); 2.4006 (0.7); 2.3325 (1.6); 2.3278 (2.1); 2.3232 (1.5); 1.9881 (10.2); 1.9085 (2.2); 1.2267 (14.8); 1.2088 (14.3); 1.1925 (3.4); 1.1746 (6.5); 1.1569 (3.1); 1.1133 (16.0); 1.0950 (15.8); 0.8755 (0.6); 0.8583 (2.7); 0.8406 (0.8); -0.0002 (19.2); -0.0085 (0.6) I.4-73:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.2316 (10.1); 8.2259 (10.1); 8.1741 (0.6); 8.1068 (5.1); 8.1026 (5.5); 8.0860 (10.6); 8.0819 (10.7); 8.0653 (6.0); 8.0613 (5.6); 7.5221 (1.4); 7.5151 (2.5); 7.5035 (13.5); 7.4978 (15.6); 7.4780 (16.0); 7.4723 (13.4); 7.4669 (3.0); 7.4606 (2.5); 7.4535 (1.5); 7.2010 (8.3); 7.1973 (14.2); 7.1805 (15.0); 7.1776 (13.6); 7.1720 (7.3); 7.1684 (7.2); 7.1516 (7.1); 7.1480 (7.8); 7.1029 (4.6); 7.0869 (9.3); 7.0669 (5.8); 7.0381 (3.3); 7.0323 (5.6); 7.0266 (2.9); 7.0150 (6.4); 7.0092 (10.9); 7.0034 (5.5); 6.9918 (3.6); 6.9860 (5.7); 6.9804 (2.8); 6.9726 (4.7); 6.9683 (4.8); 6.9598 (5.0); 6.9554 (6.1); 6.9481 (4.9); 6.9410 (5.3); 6.9367 (5.3); 6.9293 (3.1); 6.9208 (3.0); 6.9165 (2.9); 4.4292 (1.6); 4.4198 (2.8); 4.4121 (4.1); 4.4030 (4.6); 4.3942 (4.2); 4.3863 (3.0); 4.3765 (2.1); 4.1531 (8.5); 4.1366 (8.9); 4.1274 (10.8); 4.1109 (8.3); 4.0383 (1.4); 4.0205 (1.3); 3.7144 (7.5); 3.7054 (7.5); 3.6887 (7.0); 3.6797 (6.8); 3.3623 (3.4); 3.3462 (0.8); 3.3403 (0.7); 3.3121 (330.1); 3.2858 (1.9); 3.2791 (0.8); 3.2624 (5.7); 3.2130 (0.6); 3.1941 (0.7); 3.0230 (8.8); 3.0032 (9.4); 2.9802 (10.9); 2.9605 (9.8); 2.6746 (2.0); 2.6700 (2.9); 2.6653 (2.1); 2.5557 (3.3); 2.5510 (4.9); 2.5464 (3.4); 2.5289 (0.8); 2.5236 (6.1); 2.5188 (9.0); 2.5101 (156.2); 2.5055 (346.7); 2.5009 (491.5); 2.4963 (348.4); 2.4917 (160.0); 2.4746 (14.2); 2.4603 (5.2); 2.4558 (7.9); 2.4512 (10.0); 2.4464 (8.3); 2.4423 (11.1); 2.4317 (8.6); 2.4010 (1.6); 2.3818 (1.5); 2.3324 (2.4); 2.3277 (3.3); 2.3230 (2.4); 2.0730 (2.1); 1.9881 (6.4); 1.9085 (6.7); 1.2333 (0.8); 1.1925 (2.0); 1.1748 (4.0); 1.1569 (2.1); 0.1460 (0.8); 0.0499 (2.2); 0.0081 (7.6); -0.0002 (282.6); -0.0086 (9.1); -0.0500 (4.0); -0.1198 (0.6); -0.1495 (0.8) I.4-74:1H NMR (400.0MHz, d6-DMSO): δ= 8.1649 (2.9); 8.1611 (3.2); 8.1571 (2.1); 8.1547 (3.7); 8.1517 (3.7); 8.1496 (3.0); 8.1481 (3.1); 8.1462 (2.8); 8.1442 (3.5); 8.1403 (3.1); 8.0510 (1.7); 8.0451 (1.6); 8.0416 (1.7); 8.0366 (1.8); 8.0347 (1.8); 8.0319 (1.6); 8.0273 (1.9); 8.0214 (1.8); 7.9901 (4.4); 7.6480 (2.0); 7.6316 (2.0); 7.6213 (0.8); 7.6180 (0.7); 7.6113 (7.8); 7.6092 (6.2); 7.6021 (3.6); 7.5988 (3.9); 7.5968 (4.2); 7.5952 (3.9); 7.4108 (3.2); 7.4073 (3.4); 7.3908 (3.5); 7.3871 (3.5); 7.2686 (1.4); 7.2649 (1.4); 7.2500 (1.9); 7.2471 (2.4); 7.2443 (1.6); 7.2294 (1.6); 7.2256 (1.5); 6.9866 (2.4); 6.9827 (2.5); 6.9682 (2.5); 6.9667 (2.4); 6.9643 (2.5); 6.9627 (2.5); 6.9482 (2.0); 6.9442 (2.0); 4.4328 (0.6); 4.4249 (0.9); 4.4162 (1.0); 4.4070 (0.9); 4.3993 (0.7); 4.2080 (1.9); 4.1919 (2.0); 4.1823 (2.4); 4.1663 (1.8); 4.0562 (1.1); 4.0384 (3.3); 4.0206 (3.4); 4.0028 (1.1); 3.7616 (1.7); 3.7533 (1.7); 3.7361 (1.6); 3.7277 (1.6); 3.4674 (4.6); 3.1187 (0.5); 3.1067 (0.6); 3.1004 (1.7); 3.0884 (1.7); 3.0822 (1.7); 3.0702 (1.8); 3.0641 (0.6); 3.0520 (0.6); 3.0376 (2.0); 3.0181 (2.2); 2.9949 (2.4); 2.9754 (2.1); 2.6706 (0.6); 2.5516 (0.6); 2.5469 (0.5); 2.5241 (1.4); 2.5194 (2.1); 2.5107 (33.0); 2.5061 (73.2); 2.5015 (103.9); 2.4969 (72.4); 2.4923 (32.0); 2.4773 (2.4); 2.4671 (2.1); 2.4608 (0.8); 2.4560 (1.0); 2.4515 (1.4); 2.4468 (1.1); 2.4345 (1.7); 2.4245 (1.7); 2.3283 (0.7); 1.9883 (16.0); 1.9090 (10.5); 1.2022 (3.2); 1.1926 (5.0); 1.1841 (7.0); 1.1748 (9.8); 1.1658 (3.2); 1.1570 (4.6); 0.0080 (1.4); 0.0038 (0.6); -0.0002 (48.0); -0.0052 (0.6); -0.0060 (0.5); -0.0085 (1.4) I.4-75:1H NMR (400.0MHz, d6-DMSO): δ= 8.2925 (10.6); 8.2865 (10.4); 8.1686 (1.2); 8.1208 (5.6); 8.1167 (5.6); 8.1001 (11.2); 8.0959 (11.0); 8.0795 (6.3); 8.0751 (5.6); 7.4949 (5.3); 7.4913 (6.0); 7.4755 (11.0); 7.4715 (11.5); 7.4560 (6.4); 7.4517 (6.7); 7.3772 (1.9); 7.3730 (1.6); 7.3636 (2.5); 7.3595 (3.6); 7.3564 (5.9); 7.3522 (5.9); 7.3463 (3.9); 7.3388 (16.0); 7.3331 (11.2); 7.3256 (7.8); 7.3213 (7.1); 7.3179 (3.7); 7.3111 (8.7); 7.3069 (10.9); 7.2905 (4.0); 7.2860 (3.0); 7.2724 (9.8); 7.2681 (6.1); 7.2554 (10.2); 7.2530 (8.7); 7.2500 (8.3); 7.2359 (9.0); 7.2305 (5.8); 7.2211 (10.1); 7.2092 (9.5); 7.2054 (15.3); 7.1889 (7.5); 7.1853 (7.7); 7.1801 (6.5); 7.1765 (6.8); 7.1596 (7.4); 7.1561 (7.8); 7.1062 (4.8); 7.0872 (9.6); 7.0673 (5.9); 6.9720 (4.7); 6.9677 (5.0); 6.9592 (4.9); 6.9548 (6.1); 6.9475 (4.9); 6.9404 (5.3); 6.9362 (5.3); 6.9286 (2.8); 6.9201 (2.8); 6.9157 (2.6); 5.7537 (1.3); 4.4477 (4.2); 4.4392 (4.7); 4.4303 (4.5); 4.4230 (3.0); 4.1054 (7.4); 4.0894 (7.5); 4.0807 (8.6); 4.0656 (7.5); 4.0382 (1.4); 4.0203 (1.2); 3.6048 (8.0); 3.5956 (7.8); 3.5800 (7.7); 3.5711 (7.4); 3.3767 (1.4); 3.3658 (8.7); 3.3640 (6.3); 3.3156 (1864.4); 3.2914 (3.7); 3.2830 (3.2); 3.2656 (21.3); 3.2509 (1.9); 3.2333 (3.6); 3.2251 (2.2); 3.2157 (3.2); 2.9178 (9.9); 2.8982 (10.6); 2.8753 (12.4); 2.8558 (10.9); 2.6746 (4.8); 2.6699 (6.5); 2.6654 (4.9); 2.5503 (5.7); 2.5234 (15.7); 2.5187 (22.8); 2.5100 (355.8); 2.5054 (783.2); 2.5008 (1104.3); 2.4962 (771.9); 2.4916 (341.8); 2.4559 (11.2); 2.4513 (14.2); 2.4468 (11.0); 2.4007 (2.6); 2.3727 (10.0); 2.3617 (9.8); 2.3301 (10.7); 2.3230 (6.5); 2.3189 (10.2); 2.0726 (4.7); 1.9880 (5.5); 1.9082 (6.0); 1.1923 (1.7); 1.1746 (3.2); 1.1567 (1.5); 0.0080 (5.1); -0.0002 (188.5); -0.0085 (5.6); -0.0497 (1.4) I.4-76:1H NMR (400.0MHz, d6-DMSO): δ= 8.3569 (3.4); 8.2478 (1.3); 8.1606 (0.7); 8.1447 (1.3); 8.1289 (1.7); 8.1244 (2.0); 8.1080 (3.0); 8.1042 (2.8); 8.0874 (1.6); 8.0834 (1.4); 7.6953 (2.9); 7.6835 (5.6); 7.6807 (7.4); 7.6760 (4.8); 7.6616 (6.9); 7.4066 (2.3); 7.3981 (5.0); 7.3848 (3.6); 7.3795 (7.0); 7.3664 (2.4); 7.3580 (4.6); 7.2145 (1.8); 7.2108 (1.8); 7.1903 (2.7); 7.1851 (2.0); 7.1818 (2.0); 7.1611 (4.6); 7.1403 (6.5); 7.1218 (3.9); 7.1128 (3.8); 7.0924 (3.7); 7.0731 (2.0); 7.0611 (0.8); 6.9791 (1.1); 6.9748 (1.2); 6.9662 (1.4); 6.9614 (1.8); 6.9472 (1.9); 6.9272 (1.3); 5.7540 (4.4); 4.5110 (0.7); 4.1309 (1.1); 4.1172 (1.2); 4.1043 (2.3); 4.0856 (4.2); 4.0722 (4.4); 4.0645 (2.8); 4.0465 (1.3); 3.6279 (1.2); 3.6125 (1.2); 3.6016 (1.6); 3.5863 (3.0); 3.5803 (2.8); 3.5546 (0.8); 3.3650 (4.2); 3.3159 (320.3); 3.2651 (4.2); 3.2154 (0.9); 3.1133 (0.9); 3.1011 (1.0); 3.0953 (0.9); 3.0832 (0.9); 2.9755 (1.0); 2.9579 (1.4); 2.9397 (1.0); 2.6743 (1.4); 2.6700 (1.8); 2.6653 (1.4); 2.6302 (0.8); 2.6122 (1.8); 2.5930 (2.7); 2.5746 (2.4); 2.5554 (3.0); 2.5509 (3.9); 2.5462 (3.8); 2.5231 (8.7); 2.5098 (106.4); 2.5054 (213.7); 2.5008 (286.1); 2.4963 (202.7); 2.4918 (93.6); 2.4551 (3.1); 2.4507 (4.2); 2.4462 (3.4); 2.4009 (0.8); 2.3324 (1.4); 2.3275 (1.7); 2.3232 (1.2); 1.2217 (16.0); 1.2039 (15.8); 1.1952 (2.7); 1.1769 (4.0); 1.1587 (1.9); 1.1121 (6.1); 1.0938 (6.0); 0.0501 (0.6); 0.0079 (4.0); - 0.0002 (100.1); -0.0085 (4.0); -0.0501 (1.2) I.4-77:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.1545 (2.8); 8.1509 (2.8); 8.1336 (3.0); 8.1300 (2.8); 7.9750 (4.7); 7.4699 (2.0); 7.4535 (2.0); 7.4090 (2.9); 7.4055 (3.0); 7.3890 (3.1); 7.3855 (3.1); 7.2610 (1.5); 7.2575 (1.4); 7.2398 (2.7); 7.2218 (1.6); 7.2184 (1.4); 6.9795 (1.8); 6.9758 (1.8); 6.9603 (2.6); 6.9568 (2.6); 6.9411 (1.5); 6.9374 (1.4); 4.3754 (1.2); 4.3559 (1.7); 4.3359 (1.1); 4.2484 (1.2); 4.2404 (1.3); 4.2315 (1.2); 3.6412 (2.7); 3.6250 (3.0); 3.6159 (3.4); 3.5997 (3.2); 3.5124 (4.0); 3.1408 (2.2); 3.1323 (2.2); 3.1154 (2.1); 3.1069 (2.2); 3.1006 (1.0); 3.0883 (0.9); 3.0821 (0.9); 3.0697 (0.8); 2.6850 (2.0); 2.6653 (2.5); 2.6432 (2.4); 2.6234 (2.2); 2.5517 (1.0); 2.5102 (33.8); 2.5059 (68.0); 2.5015 (91.7); 2.4970 (67.7); 2.4930 (33.9); 2.4519 (1.7); 2.3284 (0.6); 2.1329 (2.2); 2.1226 (2.3); 2.0911 (2.0); 2.0809 (2.0); 1.9882 (1.1); 1.9087 (16.0); 1.7200 (1.4); 1.6930 (1.6); 1.6719 (1.4); 1.6424 (2.5); 1.6289 (1.7); 1.5292 (3.3); 1.5131 (4.1); 1.2022 (1.4); 1.1840 (2.9); 1.1747 (0.8); 1.1658 (1.4); -0.0002 (10.7) I.4-78:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.2465 (0.7); 8.2403 (0.7); 8.1511 (0.6); 8.1487 (1.1); 8.1457 (1.1); 8.1437 (0.9); 8.1422 (0.9); 8.1405 (0.7); 8.0922 (0.8); 8.0881 (0.8); 8.0421 (0.5); 8.0329 (0.5); 8.0275 (0.6); 8.0260 (0.6); 8.0184 (0.6); 8.0125 (0.5); 7.6082 (2.4); 7.6060 (2.0); 7.5992 (1.1); 7.5959 (1.2); 7.5936 (1.2); 7.5921 (1.2); 7.2279 (0.7); 7.2111 (0.7); 7.1773 (0.5); 7.1482 (0.6); 7.0876 (0.6); 4.1998 (0.6); 4.1834 (0.6); 4.1743 (0.7); 4.1580 (0.6); 3.7542 (0.5); 3.7450 (0.5); 3.3200 (14.1); 3.0193 (0.6); 2.9996 (0.7); 2.9766 (0.8); 2.9570 (0.7); 2.5119 (3.3); 2.5074 (7.2); 2.5027 (10.1); 2.4981 (7.0); 2.4935 (3.1); 2.4861 (0.7); 2.4750 (0.6); 2.4433 (0.5); 2.0743 (16.0); 1.1829 (1.0); -0.0002 (6.2) I.4-79:1H NMR (400.0MHz, d6-DMSO): δ= 8.1588 (4.0); 8.1549 (4.0); 8.1379 (4.3); 8.1340 (4.0); 7.9766 (6.2); 7.9149 (6.8); 7.9093 (2.5); 7.8977 (3.6); 7.8920 (16.0); 7.8871 (2.5); 7.8661 (2.9); 7.8613 (15.7); 7.8556 (3.1); 7.8439 (2.4); 7.8384 (6.4); 7.7740 (0.6); 7.6311 (2.8); 7.6142 (2.8); 7.4089 (4.5); 7.4054 (4.8); 7.3889 (5.2); 7.3852 (4.8); 7.2665 (2.1); 7.2632 (1.9); 7.2452 (3.4); 7.2274 (2.4); 7.2237 (2.2); 6.9859 (3.2); 6.9819 (3.3); 6.9674 (3.6); 6.9660 (3.5); 6.9636 (3.4); 6.9620 (3.5); 6.9474 (2.8); 6.9435 (2.6); 4.4245 (1.3); 4.4155 (1.6); 4.4090 (1.4); 4.2145 (2.5); 4.1985 (2.6); 4.1888 (3.2); 4.1729 (2.5); 4.0382 (0.6); 4.0202 (0.7); 3.7600 (2.2); 3.7517 (2.2); 3.7346 (2.1); 3.7261 (2.1); 3.3682 (3.0); 3.3517 (2.0); 3.3196 (489.3); 3.2819 (1.1); 3.2697 (5.3); 3.2375 (0.9); 3.2189 (0.8); 3.1288 (1.0); 3.1164 (1.1); 3.1103 (3.4); 3.0983 (3.4); 3.0920 (3.4); 3.0801 (3.3); 3.0745 (1.1); 3.0619 (1.1); 3.0537 (2.7); 3.0344 (2.9); 3.0109 (3.3); 2.9915 (2.9); 2.6744 (2.2); 2.6698 (3.0); 2.6651 (2.1); 2.5511 (3.1); 2.5462 (3.1); 2.5233 (8.8); 2.5186 (12.3); 2.5099 (163.7); 2.5053 (357.2); 2.5007 (503.5); 2.4961 (351.7); 2.4915 (157.0); 2.4600 (3.1); 2.4556 (5.1); 2.4510 (8.7); 2.4464 (5.7); 2.4414 (4.6); 2.4012 (1.2); 2.3321 (2.3); 2.3275 (3.1); 2.3228 (2.3); 2.0727 (3.8); 1.9879 (3.3); 1.9082 (1.7); 1.1968 (6.3); 1.1923 (1.5); 1.1786 (13.2); 1.1746 (2.9); 1.1604 (6.2); 0.1458 (0.6); 0.0499 (0.5); 0.0080 (6.4); 0.0055 (1.8); -0.0002 (227.1); -0.0085 (7.0); -0.0499 (2.5); -0.1499 (0.8) I.4-80:1H NMR (400.0MHz, d6-DMSO): δ= 8.1794 (0.5); 8.1723 (1.8); 8.1684 (1.9); 8.1514 (2.0); 8.1476 (1.9); 8.0939 (2.9); 8.0433 (0.6); 7.7165 (0.6); 7.7137 (0.8); 7.6943 (1.1); 7.6917 (1.3); 7.6884 (2.9); 7.6855 (3.6); 7.6804 (0.9); 7.6687 (1.9); 7.6663 (3.9); 7.6638 (3.3); 7.5425 (1.2); 7.5259 (1.3); 7.4237 (2.1); 7.4201 (2.2); 7.4102 (0.8); 7.4036 (2.8); 7.4003 (5.1); 7.3956 (1.4); 7.3918 (1.0); 7.3879 (1.0); 7.3821 (3.6); 7.3793 (3.3); 7.3701 (0.8); 7.3652 (1.0); 7.3605 (2.8); 7.2739 (1.0); 7.2701 (1.0); 7.2553 (1.3); 7.2524 (1.6); 7.2347 (1.1); 7.2310 (1.0); 7.1632 (1.0); 7.1605 (1.8); 7.1578 (1.1); 7.1421 (2.8); 7.1264 (0.8); 7.1236 (1.3); 7.1209 (0.7); 6.9957 (1.5); 6.9917 (1.6); 6.9772 (1.6); 6.9758 (1.6); 6.9733 (1.6); 6.9718 (1.8); 6.9573 (1.3); 6.9533 (1.5); 4.1237 (1.1); 4.1052 (1.9); 4.0886 (1.3); 4.0831 (1.6); 4.0787 (1.0); 4.0587 (1.0); 4.0412 (0.7); 3.6078 (1.2); 3.5922 (1.5); 3.5855 (1.4); 3.5699 (0.8); 3.3536 (13.4); 3.1092 (0.6); 3.0972 (0.5); 3.0909 (0.6); 3.0789 (0.6); 2.6701 (0.5); 2.6096 (1.1); 2.5916 (1.4); 2.5718 (1.0); 2.5520 (0.6); 2.5236 (1.2); 2.5189 (1.8); 2.5102 (26.2); 2.5056 (57.2); 2.5010 (80.1); 2.4964 (55.8); 2.4918 (24.7); 2.4557 (0.8); 2.4512 (1.1); 2.4466 (0.8); 1.9881 (0.9); 1.9086 (16.0); 1.2325 (9.3); 1.2146 (9.0); 1.1968 (1.1); 1.1786 (2.2); 1.1746 (0.7); 1.1604 (1.0); 1.1192 (1.8); 1.1009 (1.8); -0.0002 (15.7) I.4-81:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5863 (1.4); 8.4650 (0.6); 8.0326 (1.1); 8.0245 (1.2); 8.0165 (0.9); 8.0084 (0.9); 8.0042 (1.2); 7.9961 (1.0); 7.9880 (0.8); 7.9800 (0.7); 7.6946 (1.3); 7.6918 (1.6); 7.6828 (3.0); 7.6799 (3.8); 7.6749 (1.8); 7.6727 (1.9); 7.6700 (1.6); 7.6608 (4.1); 7.6582 (3.3); 7.4069 (1.3); 7.3993 (3.0); 7.3941 (1.2); 7.3883 (1.8); 7.3856 (1.8); 7.3808 (3.8); 7.3779 (2.9); 7.3718 (0.7); 7.3666 (1.4); 7.3639 (1.1); 7.3591 (2.8); 7.2746 (0.8); 7.2616 (0.9); 7.2522 (1.1); 7.2471 (1.0); 7.2391 (1.1); 7.2340 (1.0); 7.2244 (1.4); 7.2122 (1.9); 7.1989 (1.8); 7.1629 (1.2); 7.1602 (2.0); 7.1575 (1.1); 7.1417 (3.3); 7.1259 (0.9); 7.1232 (1.4); 6.7894 (0.5); 6.7806 (0.8); 6.7697 (0.7); 6.7664 (0.7); 6.7604 (1.1); 6.7470 (0.7); 6.7380 (1.0); 4.1333 (0.6); 4.1199 (0.6); 4.1078 (1.0); 4.0904 (2.5); 4.0776 (2.1); 4.0707 (1.4); 4.0559 (0.7); 4.0382 (0.9); 4.0204 (0.9); 3.6386 (0.6); 3.6335 (0.6); 3.6164 (0.7); 3.6125 (0.7); 3.6073 (0.7); 3.5904 (1.6); 3.5843 (1.6); 3.3252 (43.8); 3.2422 (0.8); 2.9866 (0.6); 2.9688 (0.8); 2.9512 (0.6); 2.6746 (0.7); 2.6699 (1.0); 2.6653 (0.7); 2.6171 (0.9); 2.5975 (1.2); 2.5791 (0.9); 2.5233 (2.6); 2.5186 (4.0); 2.5100 (53.9); 2.5054 (116.1); 2.5008 (160.7); 2.4961 (111.9); 2.4915 (49.6); 2.4553 (0.8); 2.4507 (1.0); 2.4459 (0.7); 2.3322 (0.7); 2.3275 (1.0); 2.3229 (0.7); 2.0727 (0.6); 1.9880 (4.0); 1.9083 (16.0); 1.2210 (9.4); 1.2032 (9.2); 1.1924 (1.3); 1.1746 (2.3); 1.1568 (1.1); 1.1081 (3.5); 1.0898 (3.4); -0.0002 (10.2) I.4-82:1H NMR (400.0MHz, d6-DMSO): δ= 8.4655 (1.6); 8.3876 (1.3); 7.8586 (1.8); 7.8535 (3.4); 7.8484 (1.8); 7.5226 (12.2); 7.5092 (1.9); 7.5024 (16.0); 7.4575 (2.0); 7.4375 (3.0); 7.4170 (1.5); 7.3212 (3.9); 7.3010 (4.3); 7.2807 (2.7); 7.2570 (1.2); 7.2547 (1.4); 7.2520 (1.3); 7.2495 (1.3); 7.2373 (1.1); 7.2349 (1.1); 7.2322 (1.1); 7.2298 (1.0); 5.3101 (5.7); 4.2554 (1.0); 4.2380 (1.3); 4.2273 (1.2); 4.2101 (1.3); 4.0629 (0.5); 4.0442 (0.8); 3.8252 (1.1); 3.8197 (1.0); 3.7971 (1.0); 3.7914 (1.0); 3.3950 (1.5); 3.3767 (5.0); 3.3586 (5.3); 3.3405 (2.1); 3.3148 (180.7); 3.2644 (0.7); 3.0969 (0.8); 3.0780 (3.0); 3.0603 (2.6); 3.0423 (0.8); 3.0325 (1.4); 3.0120 (1.3); 2.6698 (0.5); 2.6072 (1.1); 2.6000 (1.1); 2.5625 (0.9); 2.5557 (1.0); 2.5233 (1.7); 2.5186 (2.3); 2.5100 (34.2); 2.5054 (74.2); 2.5008 (104.1); 2.4962 (73.6); 2.4916 (33.7); 2.3276 (0.6); 1.2509 (4.2); 1.2328 (9.0); 1.2146 (4.3); 1.2091 (3.9); 1.1908 (7.4); 1.1726 (3.4) I.4-83:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0365 (2.6); 8.0309 (2.6); 7.7443 (2.4); 7.1955 (1.0); 7.1793 (1.0); 7.1444 (1.7); 7.1430 (1.6); 7.1242 (2.0); 7.1227 (2.0); 6.9131 (1.7); 6.9075 (1.7); 6.8932 (1.5); 6.8873 (1.4); 4.2384 (0.6); 4.2293 (0.5); 3.6544 (1.4); 3.6382 (1.6); 3.6289 (1.7); 3.6126 (1.5); 3.4839 (2.2); 3.1887 (1.2); 3.1797 (1.2); 3.1631 (1.2); 3.1543 (1.1); 3.0119 (2.7); 2.9936 (2.9); 2.7097 (1.0); 2.6898 (1.1); 2.6681 (1.4); 2.6481 (1.1); 2.5235 (1.0); 2.5188 (1.5); 2.5101 (24.6); 2.5055 (54.4); 2.5009 (77.1); 2.4962 (53.7); 2.4916 (23.7); 2.4510 (0.6); 2.1581 (1.2); 2.1427 (11.8); 2.1165 (1.0); 2.1057 (1.0); 1.9879 (0.6); 1.9083 (16.0); 1.8717 (0.7); 1.8549 (0.9); 1.8381 (0.7); 1.1992 (0.5); 1.1810 (1.1); 1.1628 (0.5); 0.8500 (8.4); 0.8340 (13.0); 0.8181 (8.2); 0.0081 (1.5); 0.0040 (0.6); 0.0024 (1.9); -0.0002 (56.1); -0.0050 (0.8); -0.0058 (0.7); -0.0066 (0.6); -0.0085 (1.6) I.4-84:1H NMR (400.0MHz, d6-DMSO): δ= 8.4504 (2.0); 8.0164 (1.2); 8.0083 (1.2); 8.0001 (1.2); 7.9921 (1.2); 7.9880 (1.2); 7.9801 (1.0); 7.9716 (1.2); 7.9637 (1.0); 7.2598 (1.3); 7.2468 (1.3); 7.2372 (1.4); 7.2322 (1.4); 7.2242 (1.4); 7.2192 (1.4); 7.2095 (1.3); 7.1966 (1.2); 7.1501 (1.9); 7.1331 (1.8); 6.7718 (0.8); 6.7630 (1.2); 6.7544 (0.9); 6.7519 (1.0); 6.7492 (0.8); 6.7428 (1.5); 6.7346 (0.9); 6.7293 (0.7); 6.7206 (1.0); 6.7121 (0.6); 4.3677 (1.0); 4.3488 (1.5); 4.3282 (0.9); 4.2592 (0.7); 4.2513 (1.0); 4.2427 (1.1); 4.2335 (0.9); 4.2259 (0.7); 3.6398 (2.1); 3.6234 (2.3); 3.6142 (2.6); 3.5981 (2.3); 3.4492 (10.8); 3.1318 (2.0); 3.1233 (2.3); 3.1058 (3.4); 3.0976 (2.0); 3.0936 (2.0); 3.0873 (1.9); 3.0754 (1.8); 3.0692 (0.6); 3.0571 (0.5); 2.6752 (2.9); 2.6699 (1.6); 2.6652 (1.0); 2.6558 (2.4); 2.6338 (2.8); 2.6141 (2.6); 2.5233 (3.4); 2.5187 (5.3); 2.5100 (80.0); 2.5054 (174.8); 2.5008 (243.6); 2.4961 (169.2); 2.4915 (74.7); 2.4555 (1.1); 2.4509 (1.4); 2.4462 (1.0); 2.3322 (1.0); 2.3276 (1.5); 2.3230 (1.0); 2.1319 (2.1); 2.1213 (2.1); 2.0901 (1.9); 2.0796 (1.9); 2.0727 (0.6); 1.9081 (16.0); 1.7032 (1.1); 1.6874 (1.3); 1.6546 (1.6); 1.6418 (1.8); 1.5291 (2.3); 1.5183 (2.6); 1.5121 (2.8); 1.4884 (1.5); 1.4695 (0.9); 1.1994 (3.5); 1.1812 (7.5); 1.1629 (3.5); -0.0002 (14.5) I.4-85:1H NMR (400.0MHz, d6-DMSO): δ= 8.2277 (2.5); 8.2219 (2.4); 8.1207 (1.4); 8.1165 (1.5); 8.1000 (2.8); 8.0958 (2.8); 8.0792 (1.6); 8.0750 (1.5); 7.1997 (1.6); 7.1961 (1.7); 7.1793 (1.9); 7.1757 (2.0); 7.1704 (1.6); 7.1668 (1.8); 7.1500 (1.9); 7.1465 (2.1); 7.1009 (1.2); 7.0793 (2.6); 7.0701 (1.9); 7.0623 (2.1); 7.0531 (1.9); 6.9628 (1.2); 6.9585 (1.3); 6.9500 (1.3); 6.9456 (1.6); 6.9442 (1.5); 6.9425 (1.3); 6.9382 (1.3); 6.9312 (1.4); 6.9270 (1.3); 6.9254 (1.3); 6.9195 (0.8); 6.9110 (0.8); 6.9067 (0.8); 4.5204 (1.0); 4.5004 (1.8); 4.4799 (1.0); 4.2656 (0.7); 4.2581 (1.0); 4.2489 (1.1); 4.2397 (1.0); 4.2319 (0.7); 4.0381 (0.7); 4.0203 (0.7); 3.7354 (2.6); 3.7189 (2.8); 3.7101 (3.2); 3.6936 (2.8); 3.5543 (3.9); 3.2685 (2.4); 3.2591 (2.4); 3.2431 (2.2); 3.2340 (2.1); 3.1184 (0.8); 3.1061 (0.8); 3.1001 (2.7); 3.0881 (2.7); 3.0819 (2.8); 3.0699 (2.7); 3.0636 (0.9); 3.0517 (0.9); 2.6757 (3.1); 2.6699 (1.2); 2.6652 (0.8); 2.6559 (3.0); 2.6339 (3.5); 2.6141 (3.0); 2.5234 (2.3); 2.5187 (3.5); 2.5100 (55.2); 2.5054 (122.4); 2.5008 (172.0); 2.4961 (118.7); 2.4915 (52.0); 2.4563 (0.8); 2.4517 (0.8); 2.3323 (0.7); 2.3275 (1.0); 2.3229 (0.7); 2.1958 (1.0); 2.1895 (1.2); 2.1807 (0.8); 2.1710 (2.0); 2.1650 (1.7); 2.1568 (1.0); 2.1462 (4.2); 2.1349 (3.1); 2.1222 (0.6); 2.1124 (0.6); 2.1040 (2.2); 2.0929 (2.2); 2.0727 (0.7); 2.0329 (0.5); 2.0156 (1.4); 2.0100 (1.1); 1.9996 (1.8); 1.9945 (1.5); 1.9878 (4.6); 1.9804 (1.4); 1.9716 (1.2); 1.9082 (16.0); 1.6679 (0.7); 1.6521 (2.0); 1.6431 (1.5); 1.6387 (1.9); 1.6276 (3.5); 1.6143 (2.0); 1.6030 (1.6); 1.5879 (0.6); 1.2019 (5.3); 1.1923 (1.2); 1.1837 (11.2); 1.1746 (2.3); 1.1654 (5.1); 1.1567 (1.1); 0.0079 (3.3); 0.0063 (0.9); 0.0055 (1.0); 0.0047 (1.2); 0.0038 (1.6); 0.0022 (4.6); -0.0002 (123.2); -0.0027 (5.5); -0.0044 (2.1); -0.0052 (1.5); -0.0060 (1.3); -0.0068 (1.1); -0.0085 (3.6); -0.0108 (0.6); -0.0116 (0.6) I.4-86:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4560 (1.8); 8.0198 (1.2); 8.0116 (1.2); 8.0033 (1.2); 7.9953 (1.2); 7.9913 (1.2); 7.9831 (1.1); 7.9749 (1.1); 7.9668 (1.0); 7.2604 (1.2); 7.2473 (1.3); 7.2377 (1.4); 7.2328 (1.3); 7.2247 (1.3); 7.2196 (1.3); 7.2101 (1.3); 7.1970 (1.2); 7.1475 (1.8); 7.1308 (1.7); 6.7720 (0.8); 6.7632 (1.2); 6.7547 (0.9); 6.7522 (0.9); 6.7495 (0.8); 6.7430 (1.4); 6.7348 (0.9); 6.7297 (0.8); 6.7208 (1.0); 6.7122 (0.5); 4.2610 (0.7); 4.2528 (1.0); 4.2436 (1.1); 4.2356 (0.9); 4.2269 (0.7); 4.2056 (0.7); 4.1886 (1.7); 4.1716 (2.3); 4.1546 (1.7); 4.1379 (0.6); 3.6049 (2.4); 3.5885 (2.6); 3.5794 (2.9); 3.5631 (2.6); 3.4651 (8.7); 3.1229 (0.6); 3.1117 (2.4); 3.1042 (3.2); 3.0926 (2.0); 3.0864 (3.8); 3.0776 (2.0); 3.0744 (2.2); 3.0682 (0.7); 3.0562 (0.6); 2.6746 (1.0); 2.6675 (2.7); 2.6478 (2.4); 2.6258 (2.8); 2.6061 (2.4); 2.5234 (2.7); 2.5187 (3.9); 2.5100 (72.7); 2.5054 (162.8); 2.5008 (230.4); 2.4962 (161.8); 2.4916 (72.4); 2.4557 (1.6); 2.4510 (1.9); 2.4464 (1.4); 2.4178 (0.6); 2.3323 (1.0); 2.3276 (1.5); 2.3229 (1.1); 2.1265 (2.2); 2.1158 (2.2); 2.0849 (1.9); 2.0738 (1.9); 1.9082 (16.0); 1.1998 (3.6); 1.1816 (7.6); 1.1633 (3.5); 1.0859 (13.4); 1.0689 (14.2); 1.0650 (14.6); 1.0480 (13.5); -0.0002 (15.6) I.4-87:1H NMR (400.0MHz, d6-DMSO): δ= 7.8227 (1.7); 7.8025 (2.0); 7.6052 (2.6); 7.1238 (1.5); 7.1054 (2.4); 7.0862 (1.6); 7.0670 (0.9); 7.0028 (1.0); 6.9861 (0.9); 6.8941 (1.2); 6.8911 (1.2); 6.8756 (2.0); 6.8727 (2.0); 6.8572 (0.9); 6.8541 (0.8); 4.5295 (0.6); 4.5054 (1.1); 4.4818 (0.6); 4.2432 (0.7); 4.0380 (0.5); 4.0202 (0.5); 3.7326 (1.6); 3.7161 (1.7); 3.7074 (1.9); 3.6909 (1.6); 3.5247 (3.0); 3.2714 (1.5); 3.2621 (1.5); 3.2462 (1.4); 3.2370 (1.4); 3.1217 (0.5); 3.1096 (0.6); 3.1034 (1.8); 3.0914 (1.9); 3.0852 (1.9); 3.0731 (1.9); 3.0670 (0.6); 3.0549 (0.6); 2.6755 (2.0); 2.6694 (1.0); 2.6647 (0.7); 2.6556 (1.9); 2.6337 (2.2); 2.6137 (1.9); 2.5230 (2.3); 2.5182 (3.4); 2.5096 (49.4); 2.5050 (108.6); 2.5003 (152.4); 2.4957 (105.1); 2.4911 (46.1); 2.4594 (0.5); 2.4547 (1.0); 2.4501 (1.4); 2.4455 (1.0); 2.3318 (0.7); 2.3271 (0.9); 2.3224 (0.8); 2.2665 (2.1); 2.1964 (0.8); 2.1915 (0.8); 2.1648 (16.0); 2.1535 (2.2); 2.1477 (1.6); 2.1425 (2.5); 2.1117 (1.6); 2.1005 (1.5); 2.0174 (0.8); 2.0010 (1.2); 1.9960 (1.0); 1.9877 (3.4); 1.9727 (0.8); 1.9079 (7.6); 1.6534 (1.3); 1.6403 (1.2); 1.6290 (2.3); 1.6159 (1.2); 1.6045 (1.0); 1.1998 (3.6); 1.1922 (0.9); 1.1816 (7.6); 1.1744 (1.7); 1.1633 (3.5); 1.1566 (0.8); 1.1047 (0.7); 0.0080 (2.7); -0.0002 (103.8); -0.0086 (2.9); -0.0504 (0.8) I.4-88:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.3388 (0.6); 8.4265 (4.7); 8.0060 (2.6); 7.9981 (2.4); 7.9897 (2.5); 7.9816 (2.7); 7.9698 (2.3); 7.9612 (2.2); 7.9535 (1.8); 7.2577 (2.3); 7.2446 (2.6); 7.2352 (2.8); 7.2299 (2.6); 7.2224 (2.8); 7.2173 (2.5); 7.2076 (2.4); 7.1946 (2.3); 7.1317 (4.5); 7.1150 (4.1); 6.7699 (1.6); 6.7614 (2.5); 6.7506 (2.2); 6.7409 (3.4); 6.7325 (1.8); 6.7188 (2.1); 6.7101 (0.9); 4.2132 (2.4); 4.2039 (2.4); 4.1955 (2.3); 3.5808 (4.4); 3.5641 (4.5); 3.5557 (5.1); 3.5391 (4.4); 3.3110 (75.4); 3.0629 (4.5); 3.0538 (4.2); 3.0380 (3.9); 3.0287 (3.9); 2.6704 (6.5); 2.6506 (5.9); 2.6299 (5.5); 2.6094 (4.6); 2.5563 (3.6); 2.5516 (3.7); 2.5094 (165.2); 2.5051 (313.8); 2.5007 (409.5); 2.4962 (288.6); 2.4918 (134.0); 2.3277 (2.5); 2.1286 (3.8); 2.1168 (3.8); 2.0862 (3.4); 2.0751 (3.3); 1.9881 (1.3); 1.9077 (16.0); 1.2373 (0.6); 1.1749 (0.8); 1.0474 (5.1); 0.7053 (0.7); 0.6917 (1.7); 0.6756 (3.7); 0.6633 (14.9); 0.6470 (13.1); 0.6280 (5.9); 0.6184 (2.2); 0.6032 (1.7); 0.5925 (1.1); 0.0079 (3.5); -0.0002 (77.4); -0.0084 (3.9) I.4-89:1H NMR (400.0MHz, d6-DMSO): δ= 8.4503 (1.4); 8.0212 (0.9); 8.0130 (0.9); 8.0048 (0.8); 7.9968 (0.8); 7.9927 (0.8); 7.9846 (0.8); 7.9764 (0.8); 7.9683 (0.7); 7.2606 (0.9); 7.2475 (0.9); 7.2378 (1.0); 7.2329 (1.0); 7.2249 (1.0); 7.2199 (0.9); 7.2103 (0.9); 7.1973 (0.9); 7.1627 (1.3); 7.1464 (1.2); 6.7742 (0.6); 6.7652 (0.8); 6.7568 (0.7); 6.7544 (0.7); 6.7516 (0.6); 6.7452 (1.0); 6.7370 (0.6); 6.7319 (0.5); 6.7227 (0.7); 4.5222 (0.6); 4.4990 (1.1); 4.4786 (0.6); 4.2621 (0.7); 4.2536 (0.8); 4.2447 (0.7); 3.7394 (1.5); 3.7228 (1.6); 3.7139 (1.8); 3.6975 (1.6); 3.4546 (5.8); 3.2719 (1.5); 3.2628 (1.5); 3.2466 (1.4); 3.2376 (1.3); 3.1058 (0.6); 3.0938 (0.7); 3.0875 (0.6); 3.0756 (0.7); 2.6838 (1.6); 2.6747 (0.6); 2.6699 (0.9); 2.6641 (2.0); 2.6419 (2.0); 2.6221 (1.7); 2.5347 (0.5); 2.5235 (1.7); 2.5188 (2.6); 2.5101 (45.4); 2.5055 (101.1); 2.5009 (142.8); 2.4963 (100.1); 2.4916 (44.6); 2.4741 (0.8); 2.4695 (0.7); 2.4601 (0.5); 2.4555 (0.8); 2.4509 (1.1); 2.4465 (0.8); 2.3323 (0.6); 2.3277 (0.9); 2.3230 (0.6); 2.1965 (0.6); 2.1894 (0.7); 2.1715 (1.2); 2.1647 (1.1); 2.1469 (2.6); 2.1361 (2.2); 2.1048 (1.4); 2.0938 (1.4); 2.0727 (0.6); 2.0153 (0.8); 2.0044 (1.0); 1.9995 (1.1); 1.9879 (1.0); 1.9802 (0.9); 1.9699 (0.7); 1.9082 (16.0); 1.6522 (1.2); 1.6388 (1.2); 1.6277 (2.2); 1.6144 (1.2); 1.6031 (1.0); 1.1993 (1.2); 1.1811 (2.6); 1.1629 (1.2); -0.0002 (8.9) I.4-90:1H NMR (400.0MHz, d6-DMSO): δ= 8.2307 (2.2); 8.2245 (2.2); 8.1107 (1.3); 8.1065 (1.3); 8.0900 (2.5); 8.0858 (2.4); 8.0692 (1.3); 8.0650 (1.3); 7.1987 (1.4); 7.1951 (1.5); 7.1784 (1.8); 7.1747 (1.8); 7.1694 (1.4); 7.1658 (1.5); 7.1490 (1.8); 7.1454 (1.9); 7.0982 (1.1); 7.0789 (2.3); 7.0652 (1.9); 7.0599 (1.9); 7.0490 (1.8); 6.9614 (1.2); 6.9571 (1.1); 6.9485 (1.2); 6.9441 (1.4); 6.9384 (1.1); 6.9298 (1.2); 6.9256 (1.2); 6.9180 (0.7); 6.9095 (0.7); 6.9053 (0.6); 5.7538 (0.5); 4.2644 (0.7); 4.2569 (0.9); 4.2482 (1.0); 4.2383 (0.9); 4.2316 (0.6); 3.6503 (2.4); 3.6337 (2.5); 3.6247 (2.9); 3.6082 (2.5); 3.4413 (10.6); 3.1802 (2.2); 3.1710 (2.2); 3.1547 (2.0); 3.1456 (2.0); 3.1213 (0.8); 3.1093 (0.9); 3.1030 (2.8); 3.0910 (2.8); 3.0848 (2.8); 3.0728 (2.8); 3.0666 (0.9); 3.0545 (0.8); 3.0474 (0.7); 3.0286 (0.7); 3.0143 (2.8); 2.9962 (4.9); 2.9787 (2.8); 2.9640 (0.7); 2.9454 (0.7); 2.6954 (1.7); 2.6751 (2.3); 2.6698 (1.2); 2.6651 (0.8); 2.6537 (2.1); 2.6337 (1.9); 2.5233 (2.5); 2.5185 (3.7); 2.5099 (58.2); 2.5053 (128.9); 2.5006 (181.2); 2.4960 (125.4); 2.4914 (55.4); 2.4689 (0.8); 2.4599 (0.9); 2.4553 (1.3); 2.4506 (1.6); 2.4460 (1.1); 2.4416 (0.6); 2.3321 (0.8); 2.3275 (1.1); 2.3230 (0.8); 2.1505 (2.0); 2.1396 (2.0); 2.1089 (1.7); 2.0979 (1.7); 2.0726 (1.2); 1.9879 (0.7); 1.9081 (7.4); 1.8854 (0.6); 1.8676 (1.2); 1.8509 (1.6); 1.8341 (1.3); 1.8173 (0.6); 1.2005 (5.5); 1.1822 (11.6); 1.1746 (0.7); 1.1640 (5.3); 0.8483 (14.8); 0.8354 (16.0); 0.8317 (15.8); 0.8188 (14.4); 0.0081 (3.5); 0.0057 (1.0); 0.0049 (1.2); 0.0041 (1.5); -0.0002 (127.2); -0.0057 (1.2); -0.0065 (1.0); -0.0086 (3.5); -0.0503 (1.0) I.4-91:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.8069 (1.8); 7.8043 (1.8); 7.7866 (1.9); 7.7840 (1.9); 7.6131 (2.7); 7.1228 (1.6); 7.1028 (2.4); 7.0830 (1.6); 7.0637 (1.0); 7.0184 (1.0); 7.0029 (0.9); 6.8931 (1.2); 6.8900 (1.2); 6.8746 (2.0); 6.8716 (2.0); 6.8563 (0.9); 6.8529 (0.8); 4.2350 (0.7); 3.6422 (2.5); 3.6258 (3.0); 3.6168 (3.5); 3.6005 (3.9); 3.1868 (1.6); 3.1778 (1.6); 3.1615 (1.5); 3.1525 (1.5); 3.1182 (0.7); 3.1062 (0.8); 3.1000 (2.4); 3.0880 (2.4); 3.0818 (2.4); 3.0698 (2.4); 3.0636 (0.8); 3.0513 (0.9); 3.0159 (2.2); 3.0041 (2.3); 2.9971 (2.4); 2.9856 (2.2); 2.6922 (1.3); 2.6724 (1.6); 2.6650 (0.6); 2.6505 (1.5); 2.6305 (1.4); 2.5231 (2.2); 2.5183 (3.3); 2.5097 (43.9); 2.5051 (94.3); 2.5005 (130.8); 2.4959 (90.9); 2.4913 (40.2); 2.4553 (0.9); 2.4507 (1.2); 2.4461 (0.8); 2.3319 (0.6); 2.3273 (0.8); 2.3226 (0.6); 2.2676 (1.6); 2.1618 (16.0); 2.1492 (1.8); 2.1184 (1.2); 2.1072 (1.3); 1.9877 (0.7); 1.9080 (5.8); 1.8708 (0.9); 1.8539 (1.2); 1.8370 (0.9); 1.2015 (4.8); 1.1833 (10.1); 1.1745 (0.6); 1.1651 (4.7); 0.8504 (10.5); 0.8359 (12.8); 0.8340 (12.6); 0.8196 (10.1); 0.0080 (2.3); -0.0002 (80.5); -0.0086 (2.5); -0.0500 (0.8) I.4-92:1H NMR (400.0MHz, d6-DMSO): δ= 8.4647 (1.2); 8.0111 (0.7); 8.0029 (0.7); 7.9946 (0.7); 7.9867 (0.7); 7.9825 (0.7); 7.9745 (0.7); 7.9663 (0.7); 7.9582 (0.6); 7.2594 (0.7); 7.2464 (0.8); 7.2367 (0.8); 7.2318 (0.8); 7.2237 (0.8); 7.2187 (0.8); 7.2092 (0.8); 7.1961 (0.8); 7.1771 (1.0); 7.1603 (1.0); 6.7634 (0.8); 6.7549 (0.6); 6.7524 (0.6); 6.7498 (0.5); 6.7433 (0.9); 6.7351 (0.5); 6.7213 (0.6); 4.2621 (0.6); 4.2528 (0.6); 4.2440 (0.6); 3.6861 (0.7); 3.6563 (1.8); 3.6397 (2.1); 3.6306 (2.4); 3.6141 (2.4); 3.5499 (2.8); 3.1802 (1.3); 3.1714 (1.3); 3.1547 (1.2); 3.1457 (1.1); 3.1015 (1.0); 3.0895 (1.1); 3.0833 (1.0); 3.0713 (1.1); 3.0127 (1.7); 2.9980 (1.9); 2.9940 (2.0); 2.9796 (1.6); 2.7044 (1.0); 2.6844 (1.0); 2.6747 (0.6); 2.6700 (0.8); 2.6627 (1.3); 2.6427 (1.1); 2.5235 (2.2); 2.5188 (3.2); 2.5102 (40.0); 2.5055 (86.6); 2.5009 (120.3); 2.4963 (83.6); 2.4917 (36.8); 2.4557 (0.7); 2.4510 (0.8); 2.4464 (0.6); 2.3324 (0.5); 2.3277 (0.8); 2.3231 (0.5); 2.1517 (1.1); 2.1407 (1.1); 2.1096 (1.0); 2.0988 (1.0); 1.9082 (16.0); 1.8669 (0.7); 1.8502 (0.9); 1.8332 (0.7); 1.2015 (2.0); 1.1833 (4.3); 1.1650 (2.0); 0.8473 (8.3); 0.8345 (9.0); 0.8307 (8.9); 0.8179 (8.1); -0.0002 (7.4) I.4-93:1H NMR (400.0MHz, d6-DMSO): δ= 8.1641 (9.2); 8.1603 (9.7); 8.1432 (10.3); 8.1394 (9.9); 7.9649 (13.6); 7.4631 (6.6); 7.4466 (6.7); 7.4106 (10.7); 7.4069 (11.1); 7.3905 (11.8); 7.3869 (11.9); 7.2651 (4.7); 7.2614 (4.6); 7.2465 (6.2); 7.2436 (8.0); 7.2410 (5.4); 7.2259 (5.2); 7.2222 (4.8); 6.9818 (7.6); 6.9779 (8.1); 6.9634 (8.3); 6.9619 (8.3); 6.9595 (8.2); 6.9579 (8.5); 6.9434 (6.6); 6.9395 (6.4); 5.7536 (16.0); 4.5492 (1.1); 4.5262 (2.8); 4.5058 (5.3); 4.4858 (3.0); 4.4822 (2.9); 4.4618 (1.2); 4.2883 (0.7); 4.2788 (1.4); 4.2695 (2.2); 4.2618 (3.1); 4.2528 (3.7); 4.2437 (3.2); 4.2362 (2.3); 4.2269 (1.4); 4.2169 (0.8); 4.0562 (0.6); 4.0384 (2.0); 4.0206 (2.0); 4.0028 (0.6); 3.7414 (6.8); 3.7250 (7.2); 3.7160 (8.3); 3.6997 (6.9); 3.3682 (1.9); 3.3490 (0.7); 3.3185 (408.9); 3.2914 (1.4); 3.2802 (7.0); 3.2713 (7.1); 3.2547 (6.2); 3.2461 (6.1); 3.2360 (0.9); 3.2189 (0.6); 2.6957 (7.3); 2.6758 (8.6); 2.6707 (1.6); 2.6658 (1.0); 2.6538 (9.1); 2.6340 (8.0); 2.5512 (1.2); 2.5240 (3.1); 2.5193 (4.7); 2.5106 (67.1); 2.5060 (147.5); 2.5014 (208.0); 2.4968 (145.4); 2.4922 (64.7); 2.4689 (1.1); 2.4561 (1.2); 2.4515 (1.5); 2.3329 (0.9); 2.3282 (1.3); 2.3235 (0.9); 2.2290 (0.9); 2.2166 (1.1); 2.2036 (2.7); 2.1907 (3.1); 2.1762 (4.8); 2.1716 (3.3); 2.1633 (4.7); 2.1518 (4.6); 2.1433 (9.5); 2.1389 (5.2); 2.1330 (8.3); 2.1144 (1.5); 2.1015 (6.4); 2.0910 (6.4); 2.0496 (0.6); 2.0375 (1.6); 2.0243 (2.8); 2.0197 (3.9); 2.0066 (5.0); 2.0039 (4.6); 1.9989 (4.6); 1.9943 (4.6); 1.9882 (13.1); 1.9789 (3.1); 1.9745 (3.6); 1.9672 (1.8); 1.9568 (1.5); 1.9447 (0.5); 1.9088 (6.3); 1.6701 (1.9); 1.6629 (1.5); 1.6538 (5.6); 1.6451 (4.2); 1.6406 (5.4); 1.6295 (10.2); 1.6162 (5.8); 1.6050 (4.7); 1.5902 (1.7); 1.1925 (2.8); 1.1748 (5.6); 1.1570 (2.7); -0.0002 (10.5) I.4-94:1H NMR (400.0MHz, d6-DMSO): δ= 8.1470 (6.1); 8.1431 (6.0); 8.1261 (6.5); 8.1223 (5.9); 7.9495 (7.8); 7.4468 (4.1); 7.4303 (4.0); 7.4074 (6.8); 7.4039 (7.0); 7.3874 (7.3); 7.3838 (7.1); 7.2578 (3.1); 7.2542 (2.9); 7.2391 (4.2); 7.2363 (4.8); 7.2187 (3.4); 7.2150 (2.8); 6.9775 (4.9); 6.9736 (5.2); 6.9591 (5.4); 6.9575 (5.2); 6.9551 (5.2); 6.9536 (5.0); 6.9391 (4.3); 6.9352 (4.0); 4.2254 (1.0); 4.2159 (1.5); 4.2087 (2.1); 4.1996 (2.4); 4.1901 (2.1); 4.1829 (1.5); 4.1738 (0.9); 4.1630 (0.5); 4.0559 (0.9); 4.0382 (2.7); 4.0204 (2.7); 4.0027 (1.0); 3.5827 (5.4); 3.5663 (6.0); 3.5576 (6.7); 3.5412 (5.6); 3.3648 (2.5); 3.3152 (512.3); 3.2659 (5.7); 3.2156 (0.6); 3.0683 (4.4); 3.0593 (4.4); 3.0433 (4.2); 3.0345 (4.1); 2.6909 (1.2); 2.6801 (5.5); 2.6749 (3.5); 2.6700 (3.3); 2.6614 (8.1); 2.6506 (2.2); 2.6457 (2.1); 2.6397 (4.2); 2.6198 (3.6); 2.5465 (2.3); 2.5235 (6.8); 2.5188 (9.6); 2.5101 (131.8); 2.5055 (288.8); 2.5009 (406.7); 2.4963 (284.0); 2.4916 (126.0); 2.4558 (3.8); 2.4512 (5.2); 2.4466 (4.2); 2.4004 (0.9); 2.3324 (1.9); 2.3276 (2.5); 2.3231 (1.9); 2.3183 (1.0); 2.1439 (0.7); 2.1280 (3.7); 2.1171 (3.8); 2.0860 (3.3); 2.0753 (3.2); 1.9880 (13.1); 1.8872 (1.4); 1.1924 (3.8); 1.1745 (7.9); 1.1567 (3.7); 0.8290 (0.7); 0.7098 (0.6); 0.6965 (1.8); 0.6939 (1.8); 0.6834 (1.4); 0.6781 (3.6); 0.6756 (3.5); 0.6666 (16.0); 0.6617 (5.8); 0.6561 (3.7); 0.6520 (8.8); 0.6480 (11.5); 0.6429 (5.3); 0.6412 (5.7); 0.6375 (3.6); 0.6333 (6.3); 0.6198 (1.9); 0.6144 (1.4); 0.6096 (1.9); 0.5971 (1.1); 0.0081 (2.0); -0.0002 (72.5); -0.0086 (2.2) I.4-95:1H NMR (400.0MHz, d6-DMSO): δ= 8.1478 (1.9); 8.1439 (1.9); 8.1269 (2.1); 8.1231 (2.0); 7.9804 (2.6); 7.4952 (1.0); 7.4793 (1.0); 7.4085 (2.2); 7.4049 (2.2); 7.3884 (2.4); 7.3848 (2.3); 7.2608 (1.0); 7.2571 (0.9); 7.2421 (1.3); 7.2392 (1.6); 7.2365 (1.0); 7.2216 (1.0); 7.2179 (1.0); 6.9795 (1.6); 6.9755 (1.7); 6.9610 (1.7); 6.9595 (1.6); 6.9571 (1.6); 6.9555 (1.7); 6.9411 (1.4); 6.9371 (1.3); 4.2551 (0.6); 4.2461 (0.6); 4.2372 (0.6); 3.6607 (0.7); 3.6574 (1.8); 3.6411 (1.9); 3.6318 (2.2); 3.6155 (2.0); 3.5289 (1.4); 3.1897 (1.4); 3.1809 (1.4); 3.1641 (1.3); 3.1554 (1.3); 3.0976 (0.8); 3.0855 (0.8); 3.0794 (0.8); 3.0673 (0.8); 3.0167 (2.1); 3.0098 (2.1); 2.9980 (2.2); 2.9912 (2.1); 2.7123 (1.1); 2.6924 (1.2); 2.6706 (1.6); 2.6506 (1.2); 2.5242 (0.7); 2.5195 (1.0); 2.5109 (15.1); 2.5062 (33.3); 2.5016 (47.0); 2.4970 (32.7); 2.4924 (14.3); 2.4518 (0.6); 2.1515 (1.2); 2.1409 (1.2); 2.1097 (1.1); 2.0992 (1.1); 1.9882 (0.5); 1.9089 (16.0); 1.8710 (0.8); 1.8542 (1.0); 1.8374 (0.8); 1.2035 (1.5); 1.1853 (3.2); 1.1670 (1.5); 0.8504 (9.5); 0.8344 (14.2); 0.8185 (9.2); -0.0002 (10.6) I.4-96:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.1578 (3.1); 8.1540 (3.1); 8.1370 (3.4); 8.1331 (3.2); 7.9652 (4.2); 7.4415 (2.1); 7.4250 (2.1); 7.4095 (3.6); 7.4060 (3.7); 7.3895 (3.9); 7.3858 (3.8); 7.2622 (1.5); 7.2585 (1.5); 7.2436 (2.0); 7.2407 (2.6); 7.2380 (1.7); 7.2230 (1.7); 7.2193 (1.5); 6.9800 (2.6); 6.9760 (2.8); 6.9615 (2.9); 6.9600 (2.7); 6.9576 (2.7); 6.9560 (2.8); 6.9416 (2.3); 6.9376 (2.2); 4.2589 (0.8); 4.2512 (1.0); 4.2423 (1.2); 4.2332 (1.0); 4.2258 (0.8); 4.2119 (0.8); 4.1949 (1.8); 4.1779 (2.6); 4.1609 (1.9); 4.1440 (0.8); 3.6055 (2.4); 3.5893 (2.6); 3.5801 (2.9); 3.5639 (2.5); 3.3721 (0.7); 3.3146 (157.1); 3.2646 (1.2); 3.1200 (2.3); 3.1113 (2.3); 3.0946 (2.1); 3.0859 (2.0); 2.6771 (2.7); 2.6700 (0.7); 2.6654 (0.5); 2.6573 (2.9); 2.6355 (3.3); 2.6157 (2.9); 2.5235 (1.7); 2.5188 (2.4); 2.5101 (32.6); 2.5055 (71.6); 2.5009 (100.6); 2.4963 (70.3); 2.4917 (31.1); 2.4557 (0.8); 2.4509 (0.9); 2.4464 (0.7); 2.3277 (0.6); 2.1269 (2.4); 2.1164 (2.4); 2.0853 (2.1); 2.0747 (2.1); 2.0405 (1.0); 1.9880 (0.6); 1.0904 (15.5); 1.0734 (15.8); 1.0669 (16.0); 1.0499 (15.3); 1.0265 (0.5); 0.8728 (0.9); 0.0080 (1.0); -0.0002 (41.1); -0.0086 (1.2) I.4-97:1H NMR (400.0MHz, d6-DMSO): δ= 8.1907 (4.0); 8.1849 (3.8); 8.1064 (2.2); 8.1021 (2.3); 8.0856 (4.5); 8.0814 (4.3); 8.0648 (2.4); 8.0606 (2.2); 7.1981 (2.6); 7.1945 (2.6); 7.1777 (3.0); 7.1740 (3.1); 7.1687 (2.5); 7.1651 (2.7); 7.1483 (2.9); 7.1447 (3.1); 7.0957 (1.9); 7.0765 (3.9); 7.0567 (2.4); 7.0145 (3.5); 6.9974 (3.5); 6.9598 (2.0); 6.9555 (2.0); 6.9470 (2.1); 6.9426 (2.6); 6.9368 (2.0); 6.9283 (2.2); 6.9240 (2.2); 6.9224 (2.0); 6.9165 (1.2); 6.9080 (1.2); 6.9037 (1.1); 5.7539 (1.9); 4.2264 (0.8); 4.2206 (1.1); 4.2170 (1.2); 4.2095 (1.8); 4.2003 (2.0); 4.1911 (1.8); 4.1838 (1.2); 4.1799 (1.1); 4.1738 (0.8); 3.5764 (4.9); 3.5598 (5.2); 3.5514 (5.9); 3.5349 (5.0); 3.3642 (1.8); 3.3429 (0.7); 3.3144 (321.0); 3.2841 (0.7); 3.2811 (0.6); 3.2640 (3.0); 3.0599 (4.0); 3.0505 (4.0); 3.0349 (3.8); 3.0257 (3.7); 2.6792 (1.4); 2.6746 (1.3); 2.6697 (2.4); 2.6647 (5.9); 2.6503 (3.1); 2.6457 (4.1); 2.6391 (1.9); 2.6339 (1.7); 2.6233 (4.7); 2.6037 (3.4); 2.5507 (1.7); 2.5466 (1.6); 2.5235 (3.9); 2.5188 (5.6); 2.5101 (74.6); 2.5055 (162.6); 2.5009 (228.6); 2.4962 (159.1); 2.4916 (70.1); 2.4553 (2.1); 2.4507 (2.9); 2.4462 (2.3); 2.3323 (1.0); 2.3277 (1.5); 2.3231 (1.0); 2.1268 (3.4); 2.1155 (3.4); 2.0849 (2.9); 2.0736 (3.1); 1.9880 (0.8); 1.2359 (1.3); 0.7053 (0.5); 0.6917 (1.5); 0.6874 (1.6); 0.6754 (3.7); 0.6681 (3.9); 0.6636 (16.0); 0.6594 (7.1); 0.6505 (6.0); 0.6471 (12.7); 0.6381 (3.1); 0.6363 (3.2); 0.6325 (4.4); 0.6298 (4.3); 0.6264 (4.6); 0.6177 (1.7); 0.6111 (1.4); 0.6028 (1.6); 0.5915 (0.9); 0.0080 (3.2); -0.0002 (110.7); -0.0085 (3.3); -0.0503 (0.9) I.4-98:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.2191 (2.2); 8.2131 (2.2); 8.1217 (1.3); 8.1175 (1.4); 8.1010 (2.6); 8.0968 (2.6); 8.0802 (1.4); 8.0760 (1.3); 7.2006 (1.5); 7.1970 (1.5); 7.1802 (1.7); 7.1766 (1.8); 7.1713 (1.5); 7.1677 (1.6); 7.1509 (1.7); 7.1473 (1.8); 7.0999 (1.1); 7.0799 (2.1); 7.0609 (1.3); 7.0233 (2.0); 7.0064 (2.0); 6.9614 (1.2); 6.9571 (1.3); 6.9486 (1.2); 6.9442 (1.5); 6.9428 (1.4); 6.9411 (1.2); 6.9384 (1.2); 6.9368 (1.2); 6.9299 (1.2); 6.9283 (1.1); 6.9256 (1.2); 6.9239 (1.2); 6.9181 (0.7); 6.9095 (0.7); 6.9053 (0.7); 4.2570 (0.7); 4.2491 (1.0); 4.2404 (1.2); 4.2317 (1.0); 4.2238 (0.8); 4.2076 (0.8); 4.1907 (1.9); 4.1737 (2.6); 4.1567 (1.9); 4.1398 (0.7); 3.6006 (2.4); 3.5842 (2.5); 3.5752 (2.9); 3.5588 (2.5); 3.3648 (0.7); 3.3156 (151.5); 3.2656 (1.8); 3.1097 (2.2); 3.1006 (2.2); 3.0843 (2.0); 3.0753 (2.0); 2.6701 (0.6); 2.6654 (0.5); 2.6605 (2.8); 2.6408 (2.9); 2.6189 (3.3); 2.5992 (2.9); 2.5508 (0.6); 2.5236 (1.3); 2.5189 (2.0); 2.5102 (29.8); 2.5056 (66.2); 2.5010 (93.9); 2.4964 (65.2); 2.4917 (28.7); 2.4602 (0.5); 2.4554 (0.9); 2.4508 (1.2); 2.4462 (0.9); 2.3278 (0.6); 2.1253 (2.4); 2.1144 (2.4); 2.0837 (2.1); 2.0728 (3.1); 1.0866 (15.2); 1.0696 (15.9); 1.0651 (16.0); 1.0481 (15.0); 0.0080 (0.5); -0.0002 (20.3); -0.0086 (0.5) I.4-99:1H NMR (400.0MHz, d6-DMSO): δ= 8.2084 (11.7); 8.1129 (5.4); 8.0922 (10.7); 8.0716 (6.1); 7.1959 (6.0); 7.1753 (7.3); 7.1665 (6.8); 7.1461 (8.0); 7.0969 (5.8); 7.0768 (11.1); 7.0574 (7.0); 7.0288 (10.0); 7.0125 (10.5); 6.9565 (4.2); 6.9419 (6.8); 6.9247 (6.0); 6.9087 (3.2); 5.7526 (1.5); 4.3694 (5.0); 4.3502 (7.2); 4.3303 (4.8); 4.2550 (3.8); 4.2463 (4.9); 4.2382 (5.8); 4.2290 (5.2); 3.6346 (8.3); 3.6181 (8.9); 3.6092 (10.3); 3.5930 (8.9); 3.4094 (1.5); 3.3604 (2.4); 3.3076 (733.5); 3.2745 (10.7); 3.2585 (12.7); 3.2479 (2.6); 3.1296 (9.2); 3.1205 (10.3); 3.1040 (10.4); 3.0955 (11.0); 2.6680 (16.5); 2.6479 (9.5); 2.6259 (11.0); 2.6062 (12.0); 2.5625 (3.8); 2.5571 (4.0); 2.5225 (16.2); 2.5046 (1164.6); 2.5001 (1638.1); 2.4956 (1234.1); 2.4913 (632.8); 2.4593 (36.5); 2.4546 (35.2); 2.4500 (32.8); 2.4454 (23.4); 2.4407 (14.8); 2.3269 (9.9); 2.1300 (9.6); 2.1191 (9.8); 2.0879 (8.5); 2.0775 (8.4); 1.7158 (6.4); 1.6871 (7.1); 1.6421 (10.5); 1.5291 (12.6); 1.5121 (16.0); 1.4890 (8.8); 1.4701 (5.4); 1.1941 (4.6); 1.1760 (9.2); 1.1584 (5.2); 0.0080 (3.6); -0.0002 (115.3); -0.0084 (6.1); -0.0504 (2.1) I.4-100:1H NMR (400.0MHz, d6-DMSO): δ= 8.4615 (1.4); 8.1425 (2.6); 8.1394 (2.5); 8.1359 (1.9); 8.0429 (1.2); 8.0370 (1.1); 8.0341 (1.2); 8.0276 (1.8); 8.0231 (1.1); 8.0192 (1.4); 8.0134 (1.6); 8.0069 (0.9); 7.9985 (0.8); 7.9904 (0.8); 7.9865 (0.8); 7.9784 (0.7); 7.9702 (0.8); 7.9622 (0.7); 7.6201 (0.5); 7.6096 (5.5); 7.6072 (4.8); 7.6010 (2.4); 7.5976 (2.4); 7.5945 (2.6); 7.5930 (2.5); 7.3042 (1.5); 7.2877 (1.5); 7.2617 (0.8); 7.2488 (0.9); 7.2391 (0.9); 7.2343 (0.8); 7.2259 (0.8); 7.2213 (0.8); 7.2117 (0.9); 7.1986 (0.9); 6.7825 (0.6); 6.7735 (0.8); 6.7628 (0.7); 6.7534 (1.0); 6.7452 (0.6); 6.7312 (0.7); 4.4320 (0.6); 4.4226 (0.7); 4.4135 (0.7); 4.2015 (1.3); 4.1850 (1.3); 4.1759 (1.6); 4.1596 (1.2); 3.7580 (1.2); 3.7489 (1.2); 3.7325 (1.1); 3.7234 (1.0); 3.3138 (57.1); 3.1130 (0.5); 3.1011 (0.5); 3.0949 (0.5); 3.0829 (0.5); 3.0247 (1.3); 3.0049 (1.4); 2.9819 (1.6); 2.9622 (1.4); 2.6742 (0.9); 2.6696 (1.2); 2.6649 (0.9); 2.5232 (2.1); 2.5185 (3.4); 2.5098 (64.7); 2.5052 (144.2); 2.5005 (203.5); 2.4959 (142.6); 2.4913 (63.4); 2.4721 (2.3); 2.4550 (1.0); 2.4505 (1.3); 2.4460 (1.0); 2.4409 (1.5); 2.4296 (1.2); 2.3319 (1.0); 2.3274 (1.3); 2.3228 (0.9); 1.9879 (2.1); 1.9081 (16.0); 1.1957 (1.1); 1.1924 (0.7); 1.1775 (2.3); 1.1746 (1.6); 1.1592 (1.1); 1.1568 (0.8); 0.0080 (1.7); -0.0002 (72.3); -0.0085 (2.2) I.4-101:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.5243 (2.0); 8.0219 (1.2); 8.0138 (1.2); 8.0058 (1.1); 7.9975 (1.2); 7.9937 (1.2); 7.9855 (1.0); 7.9774 (1.1); 7.9692 (1.1); 7.4948 (1.1); 7.4909 (1.2); 7.4753 (2.3); 7.4713 (2.4); 7.4555 (1.4); 7.4515 (1.4); 7.3648 (0.5); 7.3606 (0.7); 7.3575 (1.2); 7.3533 (1.2); 7.3393 (3.4); 7.3328 (4.2); 7.3266 (2.1); 7.3222 (2.1); 7.3172 (2.6); 7.3119 (2.5); 7.3075 (2.4); 7.2909 (1.0); 7.2865 (0.7); 7.2728 (2.1); 7.2689 (2.1); 7.2559 (3.1); 7.2536 (2.0); 7.2507 (1.8); 7.2468 (2.2); 7.2417 (1.4); 7.2363 (2.0); 7.2336 (1.5); 7.2310 (1.5); 7.2289 (1.4); 7.2191 (1.2); 7.2060 (1.2); 6.7822 (0.7); 6.7733 (1.2); 6.7647 (0.8); 6.7623 (1.0); 6.7597 (0.8); 6.7531 (1.4); 6.7450 (0.8); 6.7399 (0.8); 6.7310 (1.0); 6.7224 (0.5); 4.4598 (0.6); 4.4529 (0.9); 4.4433 (1.0); 4.4347 (0.9); 4.4269 (0.6); 4.1121 (1.6); 4.0961 (1.6); 4.0874 (1.8); 4.0720 (1.6); 4.0383 (0.8); 4.0204 (0.7); 3.6057 (1.8); 3.5965 (1.8); 3.5812 (1.8); 3.5717 (1.8); 3.4742 (3.0); 2.9263 (2.0); 2.9068 (2.2); 2.8838 (2.5); 2.8643 (2.2); 2.6744 (0.7); 2.6698 (1.0); 2.6652 (0.8); 2.5232 (2.2); 2.5186 (3.4); 2.5099 (57.4); 2.5053 (126.8); 2.5007 (178.0); 2.4960 (125.1); 2.4914 (55.9); 2.4603 (1.1); 2.4556 (1.4); 2.4511 (1.6); 2.4464 (1.1); 2.3740 (2.0); 2.3628 (2.0); 2.3318 (2.4); 2.3275 (1.4); 2.3205 (2.0); 1.9879 (3.3); 1.9083 (16.0); 1.1974 (0.6); 1.1924 (1.0); 1.1792 (1.4); 1.1747 (2.1); 1.1609 (0.6); 1.1568 (1.0); 0.0080 (1.4); -0.0002 (53.1); -0.0085 (1.6) I.4-102:1H NMR (400.0MHz, d6-DMSO): δ= 7.8201 (1.9); 7.7998 (2.0); 7.6822 (3.2); 7.5008 (0.9); 7.4968 (1.0); 7.4813 (1.9); 7.4772 (2.0); 7.4618 (1.1); 7.4575 (1.2); 7.3579 (0.6); 7.3551 (1.0); 7.3508 (1.1); 7.3448 (0.7); 7.3384 (3.1); 7.3348 (2.0); 7.3329 (2.1); 7.3242 (1.4); 7.3198 (1.3); 7.3112 (1.5); 7.3069 (1.9); 7.2905 (0.7); 7.2720 (1.7); 7.2676 (1.0); 7.2658 (1.0); 7.2551 (1.8); 7.2525 (1.5); 7.2498 (1.3); 7.2456 (0.8); 7.2357 (1.4); 7.2301 (0.9); 7.1734 (1.7); 7.1571 (1.7); 7.1330 (1.6); 7.1128 (2.0); 7.0904 (1.6); 7.0712 (1.0); 6.9034 (1.3); 6.9003 (1.3); 6.8849 (2.2); 6.8818 (2.1); 6.8664 (1.0); 6.8634 (0.9); 5.7544 (1.8); 4.4375 (0.7); 4.4284 (0.8); 4.4199 (0.8); 4.4126 (0.5); 4.0998 (1.3); 4.0835 (1.3); 4.0762 (1.5); 4.0600 (1.3); 3.6126 (1.4); 3.6031 (1.4); 3.5881 (1.3); 3.5786 (1.3); 3.3220 (4.6); 3.1236 (0.8); 3.1116 (0.8); 3.1054 (2.4); 3.0934 (2.5); 3.0871 (2.5); 3.0752 (2.5); 3.0690 (0.8); 3.0570 (0.8); 2.9144 (1.7); 2.8947 (1.9); 2.8721 (2.2); 2.8523 (1.9); 2.6698 (0.6); 2.5233 (1.4); 2.5186 (2.0); 2.5099 (32.6); 2.5053 (72.1); 2.5006 (101.1); 2.4960 (70.5); 2.4914 (31.2); 2.4552 (0.8); 2.4506 (1.0); 2.4460 (0.7); 2.3845 (1.6); 2.3731 (1.6); 2.3420 (1.5); 2.3309 (1.7); 2.3229 (0.6); 2.1822 (16.0); 1.9083 (5.5); 1.1987 (5.4); 1.1805 (11.4); 1.1622 (5.2); 0.0080 (1.5); 0.0048 (0.6); 0.0039 (0.8); -0.0002 (50.9); -0.0050 (0.7); -0.0059 (0.6); -0.0085 (1.4) I.4-103:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.8273 (1.9); 7.8249 (1.9); 7.8069 (2.1); 7.7411 (0.6); 7.7331 (6.3); 7.7276 (1.8); 7.7159 (2.0); 7.7104 (7.5); 7.7024 (0.7); 7.6111 (3.4); 7.4556 (0.8); 7.4476 (7.7); 7.4420 (2.0); 7.4303 (1.9); 7.4249 (6.6); 7.4168 (0.6); 7.1415 (1.8); 7.1247 (3.2); 7.1049 (2.6); 7.0880 (1.7); 7.0685 (1.0); 6.8978 (1.3); 6.8949 (1.3); 6.8793 (2.1); 6.8763 (2.1); 6.8608 (1.0); 6.8578 (0.9); 4.4030 (0.5); 4.3956 (0.8); 4.3865 (0.9); 4.3779 (0.8); 4.3699 (0.6); 4.1608 (1.5); 4.1447 (1.6); 4.1355 (1.9); 4.1194 (1.5); 3.6857 (1.4); 3.6772 (1.4); 3.6604 (1.3); 3.6521 (1.2); 3.3170 (62.7); 3.2672 (0.5); 2.9877 (1.5); 2.9682 (1.7); 2.9452 (1.9); 2.9257 (1.7); 2.5233 (0.8); 2.5186 (1.2); 2.5099 (22.9); 2.5054 (50.2); 2.5007 (70.2); 2.4961 (49.5); 2.4916 (22.4); 2.4554 (0.6); 2.4508 (0.8); 2.4460 (1.9); 2.4355 (1.5); 2.4032 (1.3); 2.3930 (1.3); 2.1594 (16.0); 1.1956 (0.7); 1.1775 (1.5); 1.1591 (0.7); 0.0080 (0.7); -0.0002 (26.6); -0.0085 (0.8) I.4-104:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0595 (3.6); 8.0537 (3.6); 7.7377 (3.5); 7.7185 (3.4); 7.7126 (1.1); 7.7062 (3.6); 7.7007 (1.8); 7.6952 (3.8); 7.6888 (1.1); 7.6829 (3.5); 7.3152 (1.8); 7.2990 (1.8); 7.2463 (4.0); 7.2404 (1.0); 7.2289 (1.2); 7.2246 (5.1); 7.2190 (1.1); 7.2074 (1.0); 7.2016 (3.5); 7.1449 (2.3); 7.1434 (2.2); 7.1246 (2.7); 7.1231 (2.7); 6.9170 (2.4); 6.9114 (2.3); 6.8969 (2.0); 6.8913 (2.0); 4.4009 (0.5); 4.3930 (0.7); 4.3843 (0.8); 4.3756 (0.8); 4.3682 (0.6); 4.1717 (1.7); 4.1557 (1.7); 4.1463 (2.1); 4.1304 (1.6); 3.6867 (1.4); 3.6783 (1.4); 3.6613 (1.3); 3.6530 (1.2); 3.3134 (195.8); 3.2634 (1.2); 2.9871 (1.6); 2.9677 (1.7); 2.9447 (2.0); 2.9253 (1.8); 2.6745 (0.6); 2.6698 (0.9); 2.6651 (0.6); 2.5233 (1.7); 2.5186 (2.6); 2.5099 (47.1); 2.5053 (104.7); 2.5007 (147.1); 2.4961 (102.6); 2.4915 (45.4); 2.4553 (1.0); 2.4508 (1.2); 2.4461 (0.9); 2.4278 (1.6); 2.4178 (1.6); 2.3855 (1.3); 2.3755 (1.3); 2.3321 (0.7); 2.3275 (0.9); 2.3228 (0.6); 2.1405 (16.0); 0.0080 (1.1); -0.0002 (39.8); -0.0085 (1.1) I.4-105:1H NMR (400.0MHz, d6-DMSO): δ= 8.0479 (3.6); 8.0422 (3.5); 7.8026 (3.5); 7.5001 (0.9); 7.4966 (1.0); 7.4811 (1.9); 7.4770 (1.9); 7.4614 (1.1); 7.4572 (1.2); 7.3570 (1.0); 7.3528 (1.0); 7.3468 (0.8); 7.3402 (3.3); 7.3345 (3.6); 7.3262 (1.7); 7.3218 (1.8); 7.3183 (2.2); 7.3131 (1.9); 7.3086 (2.0); 7.2922 (0.7); 7.2738 (1.7); 7.2693 (0.9); 7.2568 (1.7); 7.2541 (1.4); 7.2375 (1.3); 7.2320 (0.8); 7.1552 (2.4); 7.1348 (2.7); 7.1334 (2.7); 6.9239 (2.3); 6.9182 (2.3); 6.9037 (2.0); 6.8981 (1.9); 4.4467 (0.5); 4.4398 (0.8); 4.4306 (0.8); 4.4216 (0.8); 4.4145 (0.6); 4.1148 (1.2); 4.0989 (1.3); 4.0903 (1.5); 4.0742 (1.2); 3.6149 (1.4); 3.6055 (1.4); 3.5902 (1.3); 3.5811 (1.2); 3.3201 (234.8); 3.2700 (1.1); 2.9326 (1.6); 2.9129 (1.8); 2.8901 (2.1); 2.8705 (1.8); 2.6747 (0.6); 2.6700 (0.8); 2.6654 (0.6); 2.5235 (1.8); 2.5188 (2.7); 2.5101 (42.9); 2.5055 (94.2); 2.5009 (131.9); 2.4963 (91.6); 2.4917 (40.1); 2.4557 (0.7); 2.4512 (0.8); 2.4467 (0.5); 2.3829 (1.6); 2.3719 (1.6); 2.3405 (1.4); 2.3292 (1.7); 2.3231 (0.7); 2.1625 (16.0); 2.0726 (1.6); 1.1772 (0.8); 0.0080 (1.0); -0.0002 (42.0); -0.0085 (1.2) I.4-106:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.4555 (1.5); 8.0082 (0.8); 7.9998 (0.8); 7.9916 (0.8); 7.9836 (0.9); 7.9797 (0.9); 7.9715 (0.8); 7.9636 (0.8); 7.9553 (0.8); 7.9054 (2.8); 7.8997 (1.1); 7.8883 (1.9); 7.8825 (7.8); 7.8780 (1.5); 7.8629 (1.5); 7.8585 (8.0); 7.8526 (1.6); 7.8412 (1.0); 7.8356 (2.8); 7.3073 (1.5); 7.2904 (1.6); 7.2592 (0.9); 7.2463 (0.9); 7.2365 (0.9); 7.2318 (0.9); 7.2235 (0.9); 7.2187 (0.9); 7.2091 (0.9); 7.1960 (0.9); 6.7815 (0.5); 6.7726 (0.8); 6.7617 (0.7); 6.7526 (1.1); 6.7445 (0.6); 6.7302 (0.7); 4.4234 (0.7); 4.4147 (0.7); 4.2087 (1.3); 4.1923 (1.3); 4.1830 (1.7); 4.1666 (1.2); 4.0381 (1.2); 4.0204 (1.2); 3.7565 (1.2); 3.7477 (1.2); 3.7309 (1.1); 3.7220 (1.0); 3.3336 (39.2); 3.0399 (1.3); 3.0204 (1.4); 2.9972 (1.6); 2.9776 (1.4); 2.6742 (0.9); 2.6697 (1.3); 2.6651 (0.9); 2.5231 (3.8); 2.5184 (5.9); 2.5098 (74.2); 2.5052 (160.2); 2.5006 (222.2); 2.4960 (154.5); 2.4914 (69.9); 2.4596 (1.8); 2.4501 (2.0); 2.3321 (1.1); 2.3274 (1.3); 2.3228 (1.0); 2.0726 (0.8); 1.9879 (5.6); 1.9080 (16.0); 1.1956 (0.6); 1.1924 (1.6); 1.1776 (1.5); 1.1746 (3.3); 1.1568 (1.6); 0.0080 (1.8); -0.0002 (59.8); -0.0085 (1.8) I.4-107:1H NMR (400.0 MHz, i.e6-DMSO): δ= 7.9138 (0.9); 7.7011 (0.9); 7.6888 (1.0); 7.6779 (1.0); 7.6656 (1.0); 7.2384 (1.2); 7.2165 (1.5); 7.1938 (1.0); 7.1151 (1.0); 7.0952 (1.3); 7.0748 (1.0); 7.0592 (0.5); 5.3093 (1.2); 4.1096 (0.6); 3.3770 (1.0); 3.3588 (1.1); 3.3405 (0.5); 3.3153 (78.0); 3.0986 (0.9); 3.0804 (2.8); 3.0621 (2.8); 3.0440 (1.0); 2.8783 (0.6); 2.5236 (0.6); 2.5188 (0.9); 2.5102 (13.2); 2.5056 (29.0); 2.5010 (40.8); 2.4964 (28.9); 2.4918 (13.1); 2.4759 (0.6); 1.2514 (0.9); 1.2333 (1.8); 1.2150 (1.1); 1.2084 (7.7); 1.1902 (16.0); 1.1720 (7.3) I.4-108:1H NMR (400.0MHz, d6-DMSO): δ= 8.0482 (3.6); 8.0425 (3.5); 7.7415 (3.2); 7.1805 (1.3); 7.1643 (1.3); 7.1441 (2.4); 7.1426 (2.3); 7.1238 (2.7); 7.1223 (2.6); 6.9123 (2.4); 6.9067 (2.2); 6.8922 (1.9); 6.8865 (1.9); 4.3738 (0.8); 4.3548 (1.2); 4.3348 (0.7); 4.2503 (0.5); 4.2424 (0.7); 4.2338 (0.8); 4.2252 (0.7); 4.0560 (0.6); 4.0382 (1.7); 4.0204 (1.8); 4.0026 (0.6); 3.6382 (1.7); 3.6220 (1.8); 3.6129 (2.0); 3.5968 (1.8); 3.4792 (3.2); 3.1401 (1.6); 3.1314 (1.5); 3.1149 (1.4); 3.1060 (1.7); 2.6823 (1.7); 2.6701 (0.5); 2.6625 (2.0); 2.6406 (2.2); 2.6208 (1.9); 2.5236 (1.3); 2.5188 (1.9); 2.5102 (25.0); 2.5056 (54.3); 2.5010 (76.2); 2.4963 (52.7); 2.4917 (23.0); 2.4510 (0.5); 2.1450 (16.0); 2.1303 (1.8); 2.0991 (1.5); 2.0886 (1.5); 1.9880 (8.2); 1.9084 (6.3); 1.7189 (0.9); 1.7106 (0.9); 1.7066 (0.9); 1.7015 (0.8); 1.6907 (1.0); 1.6719 (0.8); 1.6506 (1.2); 1.6427 (1.5); 1.6287 (1.0); 1.5473 (0.9); 1.5406 (1.2); 1.5298 (1.8); 1.5194 (2.2); 1.5146 (2.4); 1.4912 (1.2); 1.4724 (0.7); 1.1993 (0.6); 1.1924 (2.5); 1.1811 (1.3); 1.1746 (5.0); 1.1629 (0.6); 1.1569 (2.4); 0.0081 (1.6); - 0.0002 (57.4); -0.0086 (1.6) I.4-109:1H NMR (400.0MHz, d6-DMSO): δ= 8.5431 (4.5); 7.4852 (3.1); 7.4629 (3.7); 7.4183 (6.8); 7.3961 (9.0); 7.3355 (3.5); 7.3130 (2.7); 7.2706 (9.0); 7.2488 (6.4); 6.6210 (2.7); 6.6023 (2.6); 3.6159 (2.4); 3.3066 (157.2); 3.1717 (2.4); 2.9945 (4.1); 2.9821 (4.2); 2.6694 (4.3); 2.6379 (2.4); 2.6169 (2.5); 2.5962 (2.7); 2.5093 (240.8); 2.5049 (488.2); 2.5004 (646.4); 2.4960 (461.7); 2.4918 (227.0); 2.3278 (3.5); 2.2025 (2.4); 1.1762 (2.5); 0.8441 (13.1); 0.8304 (16.0); 0.8145 (12.6); 0.0008 (104.7); -0.0002 (141.1) I.4-110:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.8350 (0.5); 8.5445 (6.6); 7.4856 (1.0); 7.4632 (1.4); 7.4317 (1.0); 7.4239 (11.7); 7.4185 (3.7); 7.4069 (4.1); 7.4015 (16.0); 7.3938 (1.7); 7.3353 (1.4); 7.3131 (1.0); 7.2803 (1.6); 7.2725 (15.7); 7.2672 (4.2); 7.2555 (3.5); 7.2503 (11.7); 7.2424 (1.1); 6.6189 (3.4); 6.6020 (3.5); 5.7531 (0.5); 4.5364 (0.6); 4.5135 (1.5); 4.4929 (2.7); 4.4730 (1.6); 4.4493 (0.6); 4.2754 (0.7); 4.2704 (0.9); 4.2651 (0.9); 4.2581 (1.6); 4.2487 (1.5); 4.2402 (1.6); 4.2328 (0.9); 4.2279 (1.0); 4.2224 (0.7); 3.7248 (3.4); 3.7077 (3.5); 3.6997 (4.0); 3.6827 (3.4); 3.3085 (65.1); 3.2638 (3.5); 3.2537 (3.4); 3.2388 (3.0); 3.2287 (3.0); 2.6742 (0.8); 2.6696 (1.1); 2.6649 (0.8); 2.6426 (3.5); 2.6223 (3.8); 2.6007 (4.5); 2.5804 (4.1); 2.5230 (3.3); 2.5183 (4.8); 2.5096 (62.4); 2.5051 (133.0); 2.5005 (183.5); 2.4959 (127.9); 2.4914 (57.6); 2.3319 (0.8); 2.3273 (1.1); 2.3227 (0.8); 2.2116 (0.7); 2.1936 (4.6); 2.1865 (3.0); 2.1817 (4.6); 2.1619 (4.3); 2.1518 (4.2); 2.1393 (5.4); 2.1128 (1.0); 2.0195 (1.0); 2.0076 (2.1); 1.9945 (2.6); 1.9885 (2.9); 1.9825 (2.2); 1.9747 (2.6); 1.9694 (1.7); 1.9629 (1.9); 1.9492 (0.8); 1.6619 (1.0); 1.6553 (0.8); 1.6460 (2.9); 1.6368 (2.2); 1.6327 (2.7); 1.6216 (5.2); 1.6082 (2.8); 1.5969 (2.3); 1.5821 (0.8); 0.0080 (3.4); -0.0002 (100.2); -0.0086 (2.7) I.4-111:1H NMR (400.0MHz, d6-DMSO): δ= 8.0566 (3.2); 8.0509 (3.2); 7.7183 (3.0); 7.1515 (1.6); 7.1461 (2.6); 7.1445 (2.4); 7.1349 (1.6); 7.1258 (2.6); 7.1242 (2.5); 6.9153 (2.1); 6.9096 (2.1); 6.8953 (1.8); 6.8895 (1.8); 5.7535 (3.4); 4.5290 (0.6); 4.5055 (1.2); 4.4854 (0.6); 4.2643 (0.5); 4.2567 (0.7); 4.2477 (0.8); 4.2387 (0.7); 3.7415 (1.5); 3.7251 (1.6); 3.7162 (1.8); 3.6998 (1.5); 3.3155 (73.7); 3.2787 (1.5); 3.2698 (1.5); 3.2534 (1.4); 3.2446 (1.3); 2.6924 (1.6); 2.6725 (1.9); 2.6505 (2.0); 2.6306 (1.8); 2.5236 (1.0); 2.5189 (1.3); 2.5102 (15.9); 2.5056 (34.3); 2.5010 (47.8); 2.4963 (33.1); 2.4917 (14.4); 2.2024 (0.7); 2.1997 (0.7); 2.1928 (0.8); 2.1750 (1.4); 2.1684 (1.2); 2.1654 (1.1); 2.1525 (2.8); 2.1434 (16.0); 2.1109 (1.4); 2.1001 (1.4); 2.0178 (0.9); 2.0074 (1.0); 2.0024 (1.2); 1.9921 (1.0); 1.9880 (2.3); 1.9830 (1.0); 1.9745 (0.8); 1.9084 (1.1); 1.6543 (1.2); 1.6453 (1.0); 1.6411 (1.2); 1.6299 (2.2); 1.6166 (1.2); 1.6053 (1.0); 1.1747 (0.8); 0.0081 (0.6); -0.0002 (21.8); -0.0086 (0.6) I.4-112:1H NMR (400.0MHz, d6-DMSO): δ= 8.0339 (3.4); 8.0282 (3.2); 7.7662 (2.7); 7.2047 (1.4); 7.1880 (1.3); 7.1409 (2.2); 7.1394 (2.1); 7.1206 (2.6); 7.1191 (2.5); 6.9094 (2.2); 6.9039 (2.1); 6.8894 (1.8); 6.8837 (1.8); 5.7542 (5.0); 4.2098 (0.5); 4.2024 (0.7); 4.1933 (0.8); 4.1842 (0.7); 3.5755 (1.9); 3.5590 (2.0); 3.5505 (2.3); 3.5340 (1.9); 3.3137 (41.8); 3.0715 (1.6); 3.0624 (1.6); 3.0465 (1.5); 3.0374 (1.4); 2.6751 (2.0); 2.6698 (1.1); 2.6654 (1.8); 2.6550 (1.9); 2.6490 (0.7); 2.6344 (1.6); 2.6131 (1.3); 2.5234 (1.3); 2.5187 (1.8); 2.5100 (31.4); 2.5054 (69.6); 2.5007 (97.8); 2.4961 (68.3); 2.4915 (30.1); 2.4554 (0.8); 2.4507 (0.9); 2.4461 (0.6); 2.3276 (0.6); 2.1439 (16.0); 2.1299 (1.5); 2.0989 (1.3); 2.0881 (1.3); 1.8026 (0.5); 1.2339 (0.5); 0.6924 (0.8); 0.6740 (1.5); 0.6726 (1.3); 0.6643 (5.0); 0.6579 (2.3); 0.6524 (2.6); 0.6498 (2.2); 0.6461 (3.9); 0.6447 (3.5); 0.6397 (2.9); 0.6340 (2.0); 0.6192 (0.5); 0.6094 (0.6); 0.0080 (1.4); 0.0040 (0.5); -0.0002 (51.5); -0.0050 (0.8); -0.0058 (0.6); -0.0066 (0.6); -0.0085 (1.5) I.4-113:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.0480 (3.5); 8.0423 (3.4); 7.7135 (3.1); 7.1457 (2.5); 7.1442 (2.4); 7.1357 (1.7); 7.1254 (3.1); 7.1239 (3.2); 6.9144 (2.3); 6.9088 (2.2); 6.8943 (1.9); 6.8886 (1.9); 4.2509 (0.5); 4.2433 (0.8); 4.2343 (0.9); 4.2255 (0.8); 4.2177 (0.6); 4.2115 (0.7); 4.1945 (1.4); 4.1775 (1.9); 4.1606 (1.4); 4.1435 (0.5); 3.6037 (1.7); 3.5875 (1.8); 3.5784 (2.1); 3.5622 (1.8); 3.3137 (135.0); 3.2637 (0.9); 3.1190 (1.6); 3.1100 (1.6); 3.0937 (1.5); 3.0848 (1.5); 2.6751 (2.1); 2.6700 (0.6); 2.6553 (2.0); 2.6335 (2.3); 2.6137 (2.0); 2.5233 (1.3); 2.5186 (1.8); 2.5100 (27.0); 2.5054 (59.2); 2.5008 (82.7); 2.4961 (57.5); 2.4915 (25.6); 2.4508 (0.6); 2.3275 (0.5); 2.2530 (0.8); 2.1429 (16.0); 2.1362 (2.6); 2.1251 (1.8); 2.0943 (1.6); 2.0835 (1.6); 1.0880 (11.0); 1.0710 (12.4); 1.0681 (12.5); 1.0510 (10.9); -0.0002 (0.9) I.4-114:1H NMR (400.0 MHz, d6-DMSO): δ= 8.2242 (3.7); 8.2178 (3.6); 8.1096 (1.9); 8.1055 (2.0); 8.0890 (3.9); 8.0848 (3.7); 8.0683 (2.1); 8.0641 (2.0); 7.7308 (1.5); 7.7227 (13.1); 7.7172 (3.7); 7.7055 (4.3); 7.7000 (15.2); 7.6920 (1.3); 7.4543 (1.8); 7.4463 (16.0); 7.4408 (4.1); 7.4292 (3.9); 7.4237 (13.2); 7.4157 (1.0); 7.1991 (5.0); 7.1953 (3.3); 7.1836 (3.7); 7.1786 (3.3); 7.1748 (2.9); 7.1697 (2.2); 7.1660 (2.2); 7.1493 (2.6); 7.1456 (2.6); 7.1033 (1.7); 7.0845 (3.4); 7.0642 (2.0); 6.9689 (1.5); 6.9646 (1.7); 6.9561 (1.8); 6.9515 (2.2); 6.9457 (1.8); 6.9371 (1.8); 6.9329 (1.8); 6.9256 (0.9); 6.9171 (0.8); 6.9128 (0.8); 4.4108 (1.1); 4.4042 (1.6); 4.3944 (1.8); 4.3854 (1.5); 4.3783 (1.1); 4.1604 (3.2); 4.1441 (3.2); 4.1351 (4.1); 4.1189 (2.9); 4.0381 (1.0); 4.0201 (0.9); 3.6860 (2.7); 3.6770 (2.8); 3.6606 (2.6); 3.6518 (2.5); 3.4317 (0.6); 3.3951 (0.6); 3.3619 (4.1); 3.3482 (0.7); 3.3445 (1.2); 3.3116 (309.1); 3.2842 (1.3); 3.2622 (4.4); 3.2113 (0.6); 2.9836 (3.2); 2.9641 (3.4); 2.9411 (3.8); 2.9216 (3.4); 2.6741 (1.5); 2.6696 (2.3); 2.6650 (1.6); 2.5553 (3.1); 2.5507 (4.4); 2.5461 (3.2); 2.5231 (5.3); 2.5184 (7.7); 2.5098 (128.3); 2.5052 (283.5); 2.5006 (400.5); 2.4959 (283.8); 2.4913 (129.9); 2.4601 (3.2); 2.4554 (5.1); 2.4508 (6.6); 2.4461 (5.3); 2.4419 (5.7); 2.4313 (4.1); 2.4000 (3.7); 2.3890 (3.1); 2.3321 (2.0); 2.3274 (2.5); 2.3226 (1.9); 2.0726 (2.8); 1.9879 (4.5); 1.1923 (1.3); 1.1745 (2.6); 1.1567 (1.4); 0.0499 (1.6); 0.0080 (4.6); -0.0002 (196.3); -0.0085 (7.0); -0.0500 (2.5); - 0.1497 (0.6) I.4-115:1H NMR (400.0 MHz, CDCl3): δ= 8.2947 (2.1); 8.2889 (2.2); 8.2818 (0.8); 8.2758 (0.7); 7.5497 (1.3); 7.5442 (1.2); 7.5384 (1.5); 7.5269 (1.7); 7.5179 (2.6); 7.3557 (0.6); 7.3125 (0.9); 7.2979 (1.1); 7.2882 (1.0); 7.2591 (305.6); 7.2292 (2.6); 7.2081 (0.7); 7.1360 (0.6); 7.1144 (0.6); 7.1082 (0.6); 7.0602 (1.8); 7.0393 (2.6); 7.0175 (1.8); 6.9951 (2.7); 6.9607 (1.3); 6.9547 (1.2); 6.9392 (1.1); 6.9332 (1.1); 5.7406 (0.6); 4.6191 (0.5); 4.2260 (0.6); 4.2104 (0.7); 4.1990 (0.8); 4.1837 (2.4); 3.8671 (0.8); 3.8417 (0.7); 3.0938 (1.0); 3.0749 (0.9); 3.0512 (0.8); 3.0320 (0.7); 2.5295 (0.7); 2.4864 (0.6); 1.5391 (34.9); 1.4150 (1.2); 1.3965 (2.0); 1.3783 (1.1); 1.3321 (11.9); 1.2831 (16.0); 1.2552 (16.0); 0.8800 (2.1); 0.8620 (1.3); 0.0688 (3.2); 0.0079 (4.1); -0.0002 (126.2); -0.0085 (5.3); -0.1498 (0.5) I.4-116:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.7619 (2.7); 9.2140 (8.5); 8.3127 (0.3); 8.2370 (3.1); 8.2229 (3.2); 8.1260 (8.6); 8.1118 (8.9); 7.6984 (6.6); 7.6861 (7.2); 7.6809 (4.5); 7.6755 (7.9); 7.6633 (7.4); 7.6523 (4.2); 7.6479 (4.0); 7.6018 (9.9); 7.5975 (10.4); 7.3798 (1.9); 7.3753 (1.9); 7.3658 (1.9); 7.3613 (1.9); 7.2686 (5.1); 7.2641 (5.3); 7.2543 (5.3); 7.2498 (5.7); 7.2397 (7.3); 7.2175 (12.4); 7.1954 (10.8); 7.1797 (4.7); 6.0235 (0.5); 6.0143 (0.4); 5.8449 (0.3); 5.8353 (0.4); 4.5961 (0.3); 4.4274 (1.5); 4.4194 (2.1); 4.4105 (2.3); 4.4015 (2.2); 4.3939 (1.6); 4.3735 (0.5); 4.1597 (3.5); 4.1428 (3.7); 4.1344 (4.4); 4.1175 (3.4); 3.9020 (16.0); 3.7017 (3.7); 3.6924 (3.8); 3.6763 (3.4); 3.6672 (3.4); 3.5087 (1.0); 3.4789 (0.6); 3.4661 (0.7); 3.4579 (0.8); 3.3481 (424.6); 3.2684 (2.3); 3.2523 (1.1); 3.2322 (0.5); 3.2202 (0.5); 3.1702 (11.1); 2.9536 (3.2); 2.9334 (3.4); 2.9110 (4.0); 2.8909 (3.9); 2.6730 (1.3); 2.5435 (1.9); 2.5085 (185.1); 2.5043 (242.2); 2.5000 (182.9); 2.4811 (6.9); 2.4490 (3.5); 2.4379 (3.4); 2.3355 (1.0); 2.3310 (1.3); 1.2347 (1.8); 0.0076 (0.9); -0.0002 (26.0); -0.0081 (1.2) I.4-117:1H NMR (400.0MHz, d6-DMSO): δ= 7.8771 (1.3); 7.8722 (2.4); 7.8677 (2.1); 7.8523 (1.2); 3.3116 (8.3); 3.0960 (1.9); 3.0778 (6.1); 3.0595 (6.2); 3.0414 (2.1); 2.5232 (1.2); 2.5185 (1.8); 2.5100 (17.2); 2.5055 (34.2); 2.5009 (45.7); 2.4964 (32.1); 2.4919 (14.7); 1.2090 (7.7); 1.1908 (16.0); 1.1725 (7.4); 0.0080 (0.8); -0.0002 (18.9); -0.0085 (0.6) I.4-118:1H NMR (400.0MHz, d6-DMSO): δ= 8.6630 (7.7); 7.4744 (0.8); 7.4654 (8.6); 7.4597 (2.9); 7.4530 (9.2); 7.4479 (4.8); 7.4425 (10.2); 7.4359 (3.2); 7.4301 (9.6); 7.4211 (0.9); 7.1426 (0.9); 7.1336 (9.8); 7.1279 (2.8); 7.1208 (1.3); 7.1163 (3.1); 7.1115 (16.0); 7.1062 (3.2); 7.1017 (1.1); 7.0947 (2.7); 7.0890 (8.6); 7.0799 (0.7); 3.3080 (83.7); 2.6741 (0.9); 2.6695 (1.2); 2.6649 (0.8); 2.5342 (0.7); 2.5229 (3.5); 2.5182 (4.9); 2.5096 (65.7); 2.5050 (141.4); 2.5004 (195.6); 2.4958 (137.9); 2.4913 (62.2); 2.3318 (0.8); 2.3272 (1.2); 2.3226 (0.8); 0.0080 (2.1); - 0.0002 (68.1); -0.0085 (1.9) I.4-119:1H NMR (400.0MHz, d6-DMSO): δ= 11.5869 (4.7); 7.9095 (6.9); 7.8879 (8.1); 7.8622 (7.1); 7.8463 (16.0); 7.8394 (14.5); 7.8267 (14.5); 7.8198 (14.7); 7.8032 (5.5); 7.7327 (6.4); 7.7140 (6.7); 7.6778 (3.9); 7.6609 (6.2); 7.6397 (5.8); 7.6196 (3.0); 7.3531 (3.3); 7.3338 (4.6); 7.1686 (3.2); 4.1729 (3.0); 3.6547 (3.4); 3.5116 (4.3); 3.3121 (1279.9); 2.8937 (3.0); 2.6740 (19.0); 2.6693 (25.2); 2.6648 (18.9); 2.5227 (80.7); 2.5177 (130.0); 2.5093 (1577.5); 2.5048 (3217.1); 2.5003 (4312.8); 2.4958 (3095.8); 2.4914 (1524.0); 2.3317 (20.8); 2.3270 (26.0); 2.3228 (19.2); 2.0720 (6.8); 1.0215 (4.7); 1.0059 (4.8); 0.1463 (2.9); 0.0079 (25.3); -0.0002 (735.5); -0.0085 (35.4); -0.1493 (3.1) I.4-120:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.7114 (16.0); 8.6185 (4.5); 8.1851 (1.8); 8.1670 (2.2); 8.1445 (1.7); 8.1239 (2.5); 8.0587 (6.8); 8.0412 (7.0); 8.0291 (1.7); 8.0099 (2.4); 7.9963 (6.8); 7.8263 (9.7); 7.8059 (11.6); 7.7105 (9.3); 7.6905 (10.0); 7.6604 (5.4); 7.6408 (9.1); 7.6210 (4.5); 7.4474 (0.7); 7.3399 (6.1); 7.3209 (10.2); 7.3014 (4.8); 7.2288 (0.8); 4.2601 (1.8); 4.2424 (5.5); 4.2246 (5.9); 4.2030 (5.7); 4.1852 (5.6); 4.1674 (1.7); 3.3099 (326.0); 3.1150 (1.0); 3.0974 (1.1); 3.0848 (1.1); 2.6740 (4.1); 2.6695 (5.3); 2.6651 (3.8); 2.5093 (371.9); 2.5049 (688.9); 2.5004 (878.4); 2.4959 (608.1); 2.4914 (272.6); 2.4621 (1.2); 2.3316 (3.9); 2.3271 (4.9); 2.3226 (3.6); 2.0722 (0.9); 1.2840 (6.1); 1.2663 (12.8); 1.2487 (11.9); 1.2311 (13.2); 1.2134 (5.8); 1.1948 (2.1); 1.1767 (4.1); 1.1586 (1.9); 1.0226 (0.8); 0.1463 (1.0); 0.0077 (13.5); -0.0002 (249.3); -0.0083 (8.9); - 0.1491 (1.0) I.4-121:1H NMR (400.0MHz, d6-DMSO): δ= 8.9959 (8.6); 8.9918 (9.3); 8.9853 (9.3); 8.9811 (8.9); 8.5644 (16.0); 8.5528 (7.5); 8.5490 (7.2); 8.5319 (7.2); 8.5282 (6.8); 8.0947 (9.4); 8.0735 (10.3); 8.0422 (7.9); 8.0390 (8.3); 8.0217 (9.2); 8.0186 (9.1); 7.8235 (7.5); 7.8201 (7.9); 7.8050 (11.3); 7.8017 (10.3); 7.7294 (11.7); 7.7192 (14.3); 7.7151 (12.9); 7.7097 (16.0); 7.6997 (12.2); 7.6957 (11.0); 7.6906 (8.1); 7.6795 (8.1); 7.6687 (7.9); 7.6587 (7.6); 7.6480 (7.5); 7.6207 (4.9); 7.6169 (4.7); 7.5989 (8.4); 7.5809 (4.9); 7.5770 (4.5); 7.1464 (6.1); 7.1445 (5.9); 7.1274 (10.4); 7.1085 (5.4); 7.1066 (5.0); 4.6119 (0.6); 4.5949 (1.9); 4.5828 (3.4); 4.5722 (2.9); 4.5658 (3.4); 4.5532 (2.0); 4.5364 (0.7); 4.3659 (6.3); 4.3491 (6.3); 4.3413 (7.7); 4.3246 (5.8); 3.8771 (6.4); 3.8666 (6.3); 3.8525 (5.9); 3.8421 (5.6); 3.0141 (5.7); 2.9942 (6.2); 2.9719 (7.2); 2.9521 (6.3); 2.6770 (0.7); 2.6724 (1.0); 2.6682 (0.7); 2.5516 (1.2); 2.5256 (5.0); 2.5122 (59.7); 2.5078 (121.2); 2.5035 (162.6); 2.4990 (115.8); 2.4945 (59.0); 2.4633 (5.3); 2.4508 (5.4); 2.3348 (0.8); 2.3303 (1.0); 2.3258 (0.7); 0.0079 (2.1); -0.0002 (46.8); -0.0081 (1.7) I.4-122:1H NMR (400.0MHz, d6-DMSO): δ= 8.7168 (2.3); 8.0175 (6.3); 7.9967 (7.0); 7.8315 (1.5); 7.8109 (1.8); 7.7402 (11.0); 7.7198 (9.0); 7.7135 (5.0); 7.7075 (10.7); 7.7023 (6.4); 7.6971 (10.0); 7.6896 (6.1); 7.6850 (9.8); 7.6758 (1.8); 7.6601 (1.8); 7.6271 (12.2); 7.6099 (12.2); 7.5802 (6.4); 7.5607 (3.6); 7.3400 (0.9); 7.3211 (1.5); 7.3020 (0.8); 7.2570 (1.3); 7.2485 (8.8); 7.2433 (3.1); 7.2265 (16.0); 7.2163 (5.6); 7.2095 (4.4); 7.2041 (9.6); 7.1974 (7.4); 7.1785 (3.6); 4.4231 (0.6); 4.4141 (1.2); 4.4057 (2.1); 4.3975 (2.9); 4.3887 (3.2); 4.3802 (3.0); 4.3720 (2.3); 4.3634 (1.4); 4.3543 (0.8); 4.1761 (4.5); 4.1600 (4.6); 4.1508 (5.5); 4.1348 (4.4); 3.6888 (4.7); 3.6806 (4.5); 3.6634 (4.4); 3.6553 (4.2); 3.3164 (21.1); 2.9885 (4.2); 2.9692 (4.4); 2.9461 (5.2); 2.9268 (4.8); 2.5576 (0.6); 2.5533 (0.6); 2.5072 (55.5); 2.5031 (69.5); 2.4991 (50.2); 2.4316 (5.3); 2.4217 (5.1); 2.3891 (4.4); 2.3793 (4.3); 2.3302 (0.5); 1.2357 (2.0); -0.0002 (16.0); -0.0084 (0.8) I.4-123:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.3106 (10.7); 8.9537 (7.0); 8.9495 (7.4); 8.9434 (7.6); 8.9391 (7.1); 8.4679 (6.5); 8.4636 (6.5); 8.4471 (7.1); 8.4429 (6.7); 8.2376 (0.8); 8.2236 (0.7); 8.1388 (11.6); 8.1246 (12.3); 8.0003 (6.2); 7.9970 (6.4); 7.9800 (7.4); 7.9766 (7.2); 7.7694 (5.6); 7.7659 (5.7); 7.7509 (9.1); 7.7475 (7.9); 7.6851 (7.8); 7.6659 (9.8); 7.6464 (5.7); 7.6246 (16.0); 7.6225 (15.0); 7.6128 (7.3); 7.6025 (6.7); 7.5920 (6.5); 7.2977 (7.0); 7.2930 (6.6); 7.2835 (7.0); 7.2789 (6.5); 7.2516 (5.9); 7.2344 (6.0); 4.5778 (2.7); 4.5599 (2.9); 4.5477 (1.8); 4.5297 (0.7); 4.3478 (4.8); 4.3306 (5.0); 4.3231 (6.0); 4.3062 (4.7); 4.1007 (1.1); 4.0878 (3.3); 4.0747 (3.4); 4.0619 (1.2); 3.8783 (4.8); 3.8675 (4.8); 3.8536 (4.6); 3.8428 (4.5); 3.3119 (162.2); 3.2801 (1.4); 3.1769 (13.4); 3.1758 (16.7); 3.1638 (13.2); 3.1627 (16.2); 3.0884 (1.0); 2.9716 (4.3); 2.9516 (4.6); 2.9294 (5.5); 2.9096 (5.0); 2.6749 (1.7); 2.6704 (2.2); 2.6660 (1.6); 2.5526 (1.5); 2.5391 (6.0); 2.5250 (10.1); 2.5101 (137.4); 2.5058 (272.4); 2.5013 (357.5); 2.4970 (259.2); 2.4929 (127.5); 2.3328 (1.7); 2.3282 (2.2); 2.3239 (1.6); 2.0730 (2.1); 1.1888 (1.7); 1.1710 (2.9); 1.1533 (1.7); 0.0009 (40.6); -0.0002 (52.5); -0.0085 (2.1) I.4-124:1H NMR (400.0MHz, d6-DMSO): δ= 8.7151 (2.2); 8.0209 (6.7); 8.0001 (7.4); 7.8299 (1.4); 7.8095 (1.8); 7.7370 (11.1); 7.7073 (1.7); 7.6882 (12.5); 7.6854 (15.3); 7.6805 (4.5); 7.6661 (16.0); 7.6637 (14.9); 7.6581 (3.0); 7.6369 (7.3); 7.6237 (9.7); 7.6048 (7.4); 7.5785 (5.9); 7.5591 (3.2); 7.4114 (1.6); 7.4065 (10.8); 7.4014 (3.7); 7.3932 (2.2); 7.3879 (14.5); 7.3852 (12.7); 7.3710 (3.9); 7.3664 (11.3); 7.3610 (1.6); 7.3500 (0.5); 7.3392 (1.0); 7.3200 (1.5); 7.3009 (0.7); 7.2139 (3.9); 7.1948 (6.7); 7.1757 (3.4); 7.1679 (3.3); 7.1653 (5.8); 7.1627 (3.6); 7.1468 (9.3); 7.1310 (2.4); 7.1284 (4.1); 7.1258 (2.4); 4.4236 (0.6); 4.4144 (1.2); 4.4061 (2.0); 4.3980 (2.8); 4.3892 (3.1); 4.3805 (2.9); 4.3724 (2.2); 4.3637 (1.4); 4.3547 (0.7); 4.1867 (5.9); 4.1708 (5.8); 4.1611 (7.2); 4.1453 (5.6); 3.6984 (5.1); 3.6904 (5.1); 3.6728 (4.7); 3.6649 (4.6); 3.3133 (24.2); 2.9985 (5.6); 2.9792 (6.0); 2.9561 (6.9); 2.9368 (6.2); 2.6708 (0.5); 2.5242 (1.4); 2.5195 (2.2); 2.5107 (28.2); 2.5062 (61.6); 2.5017 (86.2); 2.4971 (62.0); 2.4926 (28.9); 2.4350 (5.4); 2.4253 (5.4); 2.3926 (4.6); 2.3830 (4.6); 2.3284 (0.5); 1.2350 (2.2); 0.0080 (1.3); -0.0002 (43.3); -0.0085 (1.4) I.4-125:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.6605 (7.9); 8.4457 (4.0); 7.6992 (3.7); 7.6868 (4.0); 7.6816 (2.4); 7.6762 (4.4); 7.6638 (4.1); 7.4649 (8.3); 7.4525 (9.1); 7.4474 (5.0); 7.4421 (9.8); 7.4351 (3.3); 7.4297 (9.3); 7.4058 (3.7); 7.3934 (4.0); 7.3882 (2.1); 7.3829 (4.3); 7.3706 (4.1); 7.2359 (4.3); 7.2137 (6.4); 7.1913 (3.8); 7.1336 (9.5); 7.1278 (2.9); 7.1114 (16.0); 7.0947 (2.6); 7.0890 (8.5); 7.0786 (4.3); 7.0563 (6.8); 7.0338 (3.3); 6.7281 (2.2); 6.7111 (2.2); 4.3855 (1.2); 4.1411 (2.1); 4.1243 (2.0); 4.1163 (2.6); 4.0994 (2.0); 3.6781 (2.1); 3.6682 (2.0); 3.6528 (1.8); 3.6434 (1.7); 3.3574 (2.2); 3.3397 (2.3); 3.3072 (558.8); 3.2575 (1.0); 3.1746 (0.9); 3.1615 (0.9); 2.9329 (2.0); 2.9130 (2.1); 2.8906 (2.5); 2.8709 (2.3); 2.6738 (6.6); 2.6693 (9.1); 2.6647 (6.6); 2.5551 (3.9); 2.5513 (4.5); 2.5228 (26.7); 2.5180 (37.0); 2.5093 (512.2); 2.5048 (1095.1); 2.5002 (1516.1); 2.4957 (1073.3); 2.4911 (493.7); 2.4527 (3.1); 2.4214 (1.9); 2.4103 (2.0); 2.3317 (6.4); 2.3270 (9.2); 2.3225 (6.5); 2.3180 (3.2); 2.0719 (1.3); 0.1462 (2.8); 0.0505 (1.2); 0.0331 (1.6); 0.0079 (21.2); - 0.0002 (689.6); -0.0085 (20.9); -0.1494 (2.6) I.4-126:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.9561 (8.6); 8.9518 (9.3); 8.9457 (9.4); 8.9413 (9.1); 8.6487 (1.6); 8.5274 (11.2); 8.4636 (7.3); 8.4593 (7.5); 8.4427 (8.0); 8.4384 (7.6); 7.9966 (6.8); 7.9930 (7.5); 7.9761 (8.0); 7.9725 (8.1); 7.7685 (7.0); 7.7649 (7.6); 7.7501 (11.3); 7.7464 (10.2); 7.6837 (10.3); 7.6635 (10.7); 7.6449 (6.6); 7.6192 (8.5); 7.6088 (8.3); 7.5985 (8.1); 7.5880 (8.1); 7.4611 (2.0); 7.4582 (2.5); 7.4533 (0.8); 7.4394 (3.2); 7.4367 (2.8); 7.4231 (10.5); 7.4202 (13.2); 7.4153 (4.0); 7.4060 (4.4); 7.4013 (16.0); 7.3987 (13.9); 7.3934 (1.9); 7.2956 (2.2); 7.2905 (0.7); 7.2771 (2.7); 7.2745 (2.2); 7.2603 (1.0); 7.2555 (3.4); 7.2503 (11.7); 7.2454 (3.5); 7.2318 (14.2); 7.2292 (11.8); 7.2151 (3.6); 7.2105 (10.3); 7.2054 (1.3); 6.9855 (0.6); 6.9827 (1.0); 6.9798 (0.6); 6.9643 (1.8); 6.9487 (0.5); 6.9459 (0.9); 6.9431 (0.5); 6.9306 (3.0); 6.9278 (5.6); 6.9249 (3.2); 6.9118 (4.5); 6.9094 (9.4); 6.9071 (4.7); 6.8939 (2.5); 6.8910 (4.5); 6.8882 (2.4); 6.8165 (6.0); 6.7992 (6.1); 4.5954 (0.5); 4.5823 (1.1); 4.5783 (1.4); 4.5714 (1.4); 4.5654 (2.8); 4.5589 (2.1); 4.5543 (2.1); 4.5480 (2.9); 4.5350 (1.6); 4.5307 (1.3); 4.5178 (0.7); 4.3426 (6.0); 4.3257 (6.2); 4.3181 (7.6); 4.3013 (5.6); 3.8545 (5.5); 3.8436 (5.4); 3.8300 (5.1); 3.8191 (4.9); 3.3147 (45.9); 2.9632 (5.4); 2.9433 (6.0); 2.9212 (6.9); 2.9014 (6.0); 2.6706 (0.7); 2.5241 (1.9); 2.5194 (2.9); 2.5107 (38.1); 2.5061 (83.8); 2.5016 (119.0); 2.4969 (82.4); 2.4923 (39.1); 2.4609 (4.8); 2.4479 (4.7); 2.3329 (0.5); 2.3284 (0.7); 2.3237 (0.5); 1.2338 (1.3); 0.0080 (1.0); -0.0002 (35.3); -0.0085 (1.1) I.4-127:1H NMR (400.0MHz, d6-DMSO): δ= 9.1886 (4.7); 8.6684 (1.3); 8.6553 (1.3); 8.2365 (1.1); 8.2224 (1.1); 8.1255 (6.0); 8.1113 (6.2); 7.8990 (4.3); 7.8935 (1.8); 7.8820 (2.7); 7.8763 (13.0); 7.8525 (13.3); 7.8468 (2.8); 7.8352 (2.0); 7.8299 (4.2); 7.6955 (1.2); 7.6918 (1.4); 7.6534 (1.2); 7.6488 (1.2); 7.5981 (5.9); 7.5935 (6.1); 7.5862 (1.0); 7.5772 (0.9); 7.5728 (0.9); 7.3840 (0.8); 7.3792 (0.7); 7.3699 (0.7); 7.3651 (0.7); 7.2689 (3.6); 7.2641 (3.4); 7.2546 (3.4); 7.2498 (3.4); 7.1902 (2.5); 7.1736 (2.5); 4.4450 (1.1); 4.4361 (1.2); 4.4265 (1.1); 4.4195 (0.8); 4.2048 (2.1); 4.1878 (2.2); 4.1792 (2.6); 4.1622 (2.0); 3.7694 (2.0); 3.7600 (2.0); 3.7439 (1.8); 3.7342 (1.8); 3.7199 (0.8); 3.3613 (0.6); 3.3567 (0.6); 3.3435 (0.6); 3.3088 (186.4); 3.0206 (2.1); 3.0003 (2.3); 2.9776 (2.6); 2.9573 (2.3); 2.6743 (1.5); 2.6696 (2.1); 2.6651 (1.5); 2.5584 (2.3); 2.5472 (3.1); 2.5230 (5.8); 2.5182 (8.9); 2.5096 (118.7); 2.5051 (255.8); 2.5006 (354.0); 2.4960 (250.7); 2.4915 (115.2); 2.4406 (0.6); 2.3320 (1.6); 2.3274 (2.1); 2.3228 (1.5); 2.1959 (0.5); 2.1774 (1.1); 2.1588 (0.6); 1.2358 (16.0); 1.0906 (0.7); 0.8701 (0.6); 0.8623 (0.6); 0.8539 (2.1); 0.8363 (0.9); 0.0080 (1.3); -0.0002 (43.8); -0.0085 (1.4) I.4-127:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.8930 (0.7); 9.2858 (3.8); 8.6685 (0.9); 8.6549 (1.0); 8.2350 (1.2); 8.2209 (1.2); 8.1246 (5.1); 8.1104 (5.5); 7.8990 (3.7); 7.8819 (2.2); 7.8763 (11.0); 7.8516 (10.9); 7.8294 (3.6); 7.7046 (1.0); 7.7003 (1.1); 7.6466 (1.1); 7.6419 (1.2); 7.5976 (5.2); 7.5930 (5.6); 7.5819 (0.8); 7.5776 (0.7); 7.3735 (0.7); 7.3689 (0.7); 7.3596 (0.6); 7.3547 (0.7); 7.2698 (3.1); 7.2650 (3.0); 7.2555 (3.1); 7.2507 (3.2); 7.2409 (2.1); 7.2245 (2.1); 4.4350 (1.1); 4.2057 (1.9); 4.1886 (1.9); 4.1800 (2.3); 4.1632 (1.7); 4.0387 (0.8); 4.0210 (0.9); 3.7700 (1.8); 3.7604 (1.7); 3.7442 (1.6); 3.7349 (1.5); 3.3464 (3.2); 3.1215 (1.1); 3.1092 (1.2); 3.1032 (3.5); 3.0912 (3.4); 3.0850 (3.6); 3.0730 (3.5); 3.0670 (1.2); 3.0548 (1.1); 3.0210 (1.8); 3.0007 (2.0); 2.9780 (2.3); 2.9576 (2.1); 2.6707 (0.6); 2.5573 (2.3); 2.5465 (3.0); 2.5241 (2.2); 2.5106 (39.6); 2.5061 (84.0); 2.5016 (116.1); 2.4970 (80.7); 2.4925 (36.2); 2.3287 (0.6); 1.9882 (3.5); 1.9091 (11.3); 1.2352 (4.4); 1.2025 (7.7); 1.1930 (1.5); 1.1843 (16.0); 1.1751 (2.4); 1.1661 (7.5); 1.1573 (1.1); 0.8533 (0.7); 0.0081 (1.3); -0.0002 (39.9); -0.0085 (1.1) I.4-128:1H NMR (400.0MHz, d6-DMSO): δ= 8.6633 (7.3); 8.4637 (5.8); 7.8999 (5.6); 7.8770 (16.0); 7.8492 (15.7); 7.8264 (6.1); 7.4652 (7.9); 7.4530 (8.6); 7.4476 (4.8); 7.4424 (10.0); 7.4301 (9.2); 7.4047 (5.2); 7.3925 (5.6); 7.3817 (6.8); 7.3694 (6.1); 7.1336 (9.4); 7.1114 (15.6); 7.0890 (8.4); 7.0781 (6.9); 7.0558 (10.2); 7.0336 (5.5); 6.7475 (3.1); 6.7308 (3.4); 4.1880 (2.8); 4.1706 (3.0); 4.1620 (3.4); 4.1451 (3.2); 3.7455 (3.0); 3.7206 (2.3); 3.7097 (2.3); 3.3080 (256.1); 3.0014 (2.7); 2.9816 (2.9); 2.9587 (3.5); 2.9387 (3.1); 2.6691 (3.5); 2.5555 (2.2); 2.5337 (3.6); 2.5228 (10.4); 2.5183 (11.7); 2.5095 (205.2); 2.5049 (458.1); 2.5003 (647.4); 2.4957 (459.1); 2.4912 (211.7); 2.4505 (3.0); 2.3273 (3.6); 0.0081 (5.0); -0.0002 (169.5); -0.0086 (5.0) I.4-129:1H NMR (400.0MHz, d6-DMSO): δ= 8.4363 (6.3); 8.0675 (4.1); 8.0461 (4.3); 7.9110 (5.7); 7.8939 (3.3); 7.8882 (16.0); 7.8611 (15.9); 7.8554 (3.4); 7.8438 (2.3); 7.8384 (5.8); 7.7013 (3.7); 7.6978 (3.9); 7.6821 (3.9); 7.6781 (4.3); 7.6252 (3.2); 7.6091 (5.0); 7.5915 (3.6); 7.5734 (2.1); 7.5694 (1.9); 7.1401 (2.9); 7.1374 (2.8); 7.1187 (4.6); 7.1020 (2.5); 7.0993 (2.4); 4.4259 (1.6); 4.2188 (2.7); 4.2023 (2.8); 4.1929 (3.2); 4.1768 (2.4); 3.7790 (2.4); 3.7709 (2.4); 3.7541 (2.2); 3.7460 (2.2); 3.3107 (160.2); 3.0529 (2.6); 3.0333 (2.9); 3.0101 (3.1); 2.9902 (2.9); 2.6698 (1.4); 2.5400 (4.9); 2.5236 (4.7); 2.5100 (83.8); 2.5054 (182.6); 2.5008 (255.0); 2.4962 (180.0); 2.4917 (81.2); 2.4734 (2.8); 2.3274 (1.5); 2.0725 (2.0); 0.0081 (1.6); -0.0002 (58.8); - 0.0085 (1.6) I.4-130:1H NMR (400.0MHz, d6-DMSO): δ= 8.4283 (12.0); 8.0794 (8.4); 8.0584 (8.9); 7.7119 (8.3); 7.6992 (15.5); 7.6890 (10.2); 7.6771 (16.0); 7.6252 (6.2); 7.6088 (9.4); 7.5908 (6.8); 7.5697 (3.7); 7.2468 (8.6); 7.2239 (15.0); 7.2025 (7.9); 7.1348 (5.1); 7.1148 (7.9); 7.0959 (4.2); 4.4066 (3.7); 4.1760 (4.2); 4.1605 (4.9); 4.1501 (5.6); 4.1342 (4.3); 3.7042 (5.3); 3.6791 (5.1); 3.3115 (355.7); 2.9868 (4.3); 2.9669 (5.0); 2.9441 (5.2); 2.9239 (5.0); 2.6700 (3.6); 2.5003 (611.3); 2.4519 (7.0); 2.4423 (6.4); 2.4098 (4.6); 2.3991 (4.7); 2.3278 (3.6); -0.0002 (72.8) I.4-131:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.1892 (10.8); 8.1259 (13.9); 8.1117 (14.4); 7.6675 (11.4); 7.6647 (14.5); 7.6455 (16.0); 7.6431 (14.0); 7.6057 (14.5); 7.6012 (14.7); 7.3962 (10.9); 7.3911 (3.7); 7.3775 (14.9); 7.3607 (4.0); 7.3561 (10.8); 7.2716 (8.8); 7.2668 (8.5); 7.2574 (8.4); 7.2526 (8.3); 7.2038 (5.6); 7.1869 (5.6); 7.1580 (5.7); 7.1395 (9.4); 7.1210 (4.1); 4.4338 (1.9); 4.4261 (2.6); 4.4169 (3.1); 4.4080 (2.8); 4.4004 (2.0); 4.3805 (0.7); 4.1715 (5.7); 4.1546 (5.8); 4.1460 (7.0); 4.1292 (5.5); 3.7176 (5.4); 3.7083 (5.3); 3.6922 (4.9); 3.6830 (4.7); 2.9624 (5.5); 2.9422 (5.9); 2.9198 (7.0); 2.8998 (6.3); 2.6716 (0.7); 2.5248 (1.9); 2.5115 (40.1); 2.5070 (87.8); 2.5025 (127.2); 2.4979 (88.3); 2.4933 (44.2); 2.4604 (4.7); 2.4492 (4.9); 2.3297 (0.7); - 0.0002 (9.4) I.4-132:1H NMR (400.0MHz, d6-DMSO): δ= 8.4251 (10.2); 8.0863 (6.5); 8.0656 (7.1); 7.6996 (5.8); 7.6959 (6.6); 7.6810 (14.9); 7.6786 (16.0); 7.6769 (14.2); 7.6593 (14.1); 7.6568 (12.0); 7.6511 (1.8); 7.6366 (5.1); 7.6201 (5.2); 7.6122 (4.2); 7.6081 (3.7); 7.5934 (4.4); 7.5901 (5.9); 7.5869 (3.8); 7.5722 (3.6); 7.5682 (3.3); 7.4097 (1.4); 7.4048 (9.7); 7.3996 (3.0); 7.3916 (1.9); 7.3862 (12.8); 7.3833 (10.4); 7.3693 (3.4); 7.3646 (9.8); 7.3592 (1.3); 7.1667 (2.7); 7.1640 (5.0); 7.1614 (2.8); 7.1456 (8.3); 7.1350 (5.0); 7.1323 (5.3); 7.1300 (2.8); 7.1272 (4.0); 7.1245 (2.3); 7.1160 (7.7); 7.1135 (7.6); 7.0970 (4.4); 7.0943 (4.3); 4.4368 (0.5); 4.4270 (1.0); 4.4187 (1.7); 4.4105 (2.3); 4.4019 (2.6); 4.3927 (2.4); 4.3849 (1.8); 4.3760 (1.1); 4.3666 (0.6); 4.1888 (5.1); 4.1728 (5.1); 4.1633 (6.2); 4.1473 (4.8); 3.7169 (4.4); 3.7089 (4.3); 3.6914 (4.0); 3.6834 (3.9); 3.3624 (2.1); 3.3437 (0.6); 3.3119 (343.1); 3.2885 (0.6); 3.2633 (1.4); 2.9976 (4.9); 2.9781 (5.2); 2.9551 (6.0); 2.9357 (5.4); 2.6744 (1.2); 2.6698 (1.7); 2.6652 (1.2); 2.5601 (0.8); 2.5553 (1.2); 2.5507 (1.5); 2.5460 (0.9); 2.5232 (4.7); 2.5186 (6.8); 2.5099 (97.0); 2.5053 (211.0); 2.5007 (294.3); 2.4961 (207.3); 2.4916 (94.6); 2.4591 (5.3); 2.4492 (4.6); 2.4166 (3.8); 2.4068 (4.0); 2.3321 (1.2); 2.3275 (1.7); 2.3228 (1.2); 2.0723 (1.0); 1.9879 (0.8); 1.2352 (0.8); 1.1746 (0.5); 0.0080 (1.6); -0.0002 (53.5); -0.0085 (1.5) I.4-133:1H NMR (400.0MHz, d6-DMSO): δ= 8.6353 (1.2); 8.3708 (2.4); 7.4613 (1.6); 7.4585 (1.8); 7.4537 (0.6); 7.4396 (2.1); 7.4370 (1.9); 7.3892 (2.4); 7.3864 (3.1); 7.3816 (0.9); 7.3676 (3.8); 7.3650 (3.3); 7.2949 (1.6); 7.2764 (2.0); 7.2741 (1.6); 7.2597 (0.5); 7.2552 (1.4); 7.2365 (2.7); 7.2315 (0.9); 7.2179 (3.5); 7.2156 (2.8); 7.2103 (0.7); 7.2012 (0.9); 7.1967 (2.3); 6.9821 (0.7); 6.9637 (1.2); 6.9615 (0.6); 6.9453 (0.6); 6.9191 (0.7); 6.9163 (1.3); 6.9135 (0.9); 6.8980 (2.2); 6.8956 (1.1); 6.8824 (0.6); 6.8796 (1.0); 6.8768 (0.5); 6.5411 (1.3); 6.5241 (1.3); 4.2503 (0.7); 4.2416 (0.6); 4.2327 (0.7); 4.1903 (1.1); 4.1733 (1.5); 4.1564 (1.1); 3.5918 (1.4); 3.5749 (1.5); 3.5667 (1.7); 3.5499 (1.5); 3.3282 (0.6); 3.3213 (6.2); 3.1112 (1.4); 3.1012 (1.4); 3.0861 (1.3); 3.0762 (1.3); 2.6329 (1.5); 2.6127 (1.6); 2.5913 (1.8); 2.5711 (1.7); 2.5104 (3.8); 2.5059 (8.2); 2.5013 (11.4); 2.4967 (8.0); 2.4922 (3.7); 2.1717 (1.5); 2.1596 (1.5); 2.1301 (1.3); 2.1180 (1.3); 1.2347 (0.7); 1.1018 (0.5); 1.0805 (9.0); 1.0641 (16.0); 1.0476 (8.7) I.4-134:1H NMR (400.0 MHz, i.e6-DMSO): δ= 8.6754 (7.9); 7.4657 (8.3); 7.4600 (2.9); 7.4533 (8.8); 7.4481 (4.8); 7.4428 (9.8); 7.4361 (3.2); 7.4305 (9.2); 7.4218 (0.9); 7.1424 (1.0); 7.1335 (9.5); 7.1279 (2.8); 7.1114 (16.0); 7.0946 (2.5); 7.0890 (8.3); 7.0546 (0.6); 3.3091 (56.3); 2.6693 (0.9); 2.5232 (2.4); 2.5184 (3.6); 2.5096 (55.4); 2.5051 (120.2); 2.5005 (167.8); 2.4960 (118.8); 2.4915 (54.5); 2.3275 (0.9); 1.2354 (4.0); 1.0762 (1.0); 1.0600 (1.4); 1.0446 (0.9); 0.0080 (1.3); -0.0002 (43.8); -0.0086 (1.4) I.4-135:1H NMR (400.0 MHz, CDCl3): δ= 8.3320 (3.6); 8.3300 (3.7); 8.3212 (0.6); 8.3098 (3.8); 8.3073 (3.5); 7.7105 (3.8); 7.5480 (1.4); 7.5441 (2.2); 7.5349 (3.7); 7.5305 (5.1); 7.5257 (4.5); 7.5217 (1.6); 7.5155 (4.0); 7.5113 (4.7); 7.5071 (2.8); 7.5031 (1.0); 7.2620 (36.2); 7.1388 (1.6); 7.1229 (1.6); 7.0512 (2.4); 7.0488 (2.4); 7.0323 (3.7); 7.0298 (4.1); 7.0132 (2.1); 7.0107 (2.0); 4.5123 (0.6); 4.4950 (1.4); 4.4816 (1.4); 4.4642 (0.6); 4.4315 (0.7); 4.4145 (1.8); 4.3976 (2.5); 4.3807 (1.8); 4.3637 (0.7); 3.6972 (2.2); 3.6835 (2.3); 3.6702 (2.8); 3.6565 (2.5); 3.4070 (2.6); 3.4029 (2.5); 3.3801 (2.2); 3.3760 (2.1); 2.9208 (2.1); 2.9022 (2.2); 2.8782 (2.6); 2.8597 (2.3); 2.2891 (2.2); 2.2838 (2.2); 2.2466 (2.0); 2.2413 (1.9); 1.1669 (15.6); 1.1579 (15.9); 1.1500 (16.0); 1.1409 (15.1); -0.0002 (13.8) I.4-136:1H NMR (400.0MHz, d6-DMSO): δ= 9.1709 (0.9); 8.7109 (16.0); 7.8263 (9.3); 7.8057 (11.6); 7.7288 (0.8); 7.7102 (9.3); 7.7073 (9.7); 7.6904 (9.7); 7.6874 (10.3); 7.6601 (5.2); 7.6408 (8.7); 7.6214 (4.4); 7.5493 (0.5); 7.5052 (0.7); 7.4853 (0.6); 7.4551 (0.6); 7.3395 (6.2); 7.3205 (9.9); 7.3014 (4.7); 4.2794 (2.8); 3.3410 (0.5); 3.3075 (184.8); 3.1624 (0.5); 2.6787 (0.8); 2.6741 (1.7); 2.6695 (2.4); 2.6649 (1.7); 2.6602 (0.8); 2.6198 (0.6); 2.5635 (0.5); 2.5365 (1.5); 2.5318 (1.9); 2.5229 (7.8); 2.5182 (10.7); 2.5095 (126.4); 2.5050 (271.8); 2.5004 (378.3); 2.4957 (264.2); 2.4912 (117.7); 2.4498 (0.7); 2.4450 (0.6); 2.3365 (0.7); 2.3319 (1.5); 2.3272 (2.2); 2.3226 (1.5); 2.3180 (0.7); 2.0721 (0.9); 1.2357 (2.0); 1.0202 (0.5); 0.0080 (2.8); -0.0002 (92.7); - 0.0085 (2.6) I.4-137:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.1350 (0.7); 9.1302 (0.7); 8.8737 (0.6); 8.8588 (0.6); 7.7353 (0.5); 7.7283 (0.5); 7.7203 (0.5); 7.7132 (0.5); 7.6996 (0.7); 7.6872 (0.8); 7.6787 (1.7); 7.6664 (1.8); 7.6558 (1.7); 7.6436 (1.6); 7.2727 (1.7); 7.2506 (2.7); 7.2392 (1.0); 7.2337 (0.7); 7.2282 (1.6); 7.2171 (1.3); 7.1945 (0.7); 4.2182 (0.5); 4.2079 (0.5); 4.1909 (0.5); 3.7757 (0.6); 3.7474 (0.6); 3.3101 (36.0); 3.1047 (1.9); 3.0865 (6.2); 3.0683 (6.4); 3.0501 (2.1); 3.0229 (0.6); 2.9990 (0.7); 2.9782 (0.6); 2.6742 (0.7); 2.6697 (1.0); 2.6650 (0.7); 2.5605 (0.7); 2.5537 (0.8); 2.5230 (2.9); 2.5182 (4.6); 2.5096 (59.4); 2.5051 (125.4); 2.5005 (172.3); 2.4960 (121.2); 2.4915 (55.0); 2.4450 (0.6); 2.3320 (0.8); 2.3274 (1.0); 2.3227 (0.8); 2.0725 (0.6); 1.2035 (7.7); 1.1853 (16.0); 1.1671 (7.4); 0.0080 (2.3); -0.0002 (67.2); -0.0086 (1.8) I.4-138:1H NMR (400.0 MHz, i.e6-DMSO): δ= 3.3134 (3.7); 3.0912 (0.8); 3.0735 (2.4); 3.0642 (2.8); 3.0557 (2.6); 3.0462 (2.7); 3.0282 (0.9); 2.5057 (15.3); 2.5013 (20.4); 2.4969 (15.2); 1.2141 (7.9); 1.1959 (16.0); 1.1777 (7.6); -0.0002 (5.5) I.4-139:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.3080 (2.9); 8.3646 (0.7); 8.3487 (0.7); 7.6715 (2.2); 7.6518 (2.6); 7.6447 (1.4); 7.6235 (1.1); 7.5008 (2.8); 7.4959 (1.3); 7.4796 (5.4); 7.4748 (1.2); 7.4664 (2.0); 7.4611 (5.2); 7.4557 (0.9); 7.4031 (2.4); 7.3926 (6.4); 7.3894 (8.4); 7.3839 (5.4); 7.3734 (4.6); 7.3707 (5.7); 7.3683 (5.4); 7.3632 (3.4); 7.3524 (2.5); 7.3495 (2.6); 7.3312 (3.5); 7.3158 (1.0); 7.3130 (1.4); 7.2283 (0.8); 7.2098 (1.2); 7.1914 (0.7); 7.1798 (1.0); 7.1735 (5.0); 7.1677 (2.4); 7.1611 (2.0); 7.1550 (5.7); 7.1515 (7.5); 7.1460 (3.1); 7.1401 (3.8); 7.1339 (6.2); 7.1271 (2.0); 7.1205 (1.8); 6.8720 (1.4); 6.7752 (2.5); 6.7728 (2.3); 6.7589 (9.7); 6.7578 (10.0); 6.7434 (3.2); 6.7381 (12.8); 6.7306 (0.8); 6.6296 (0.6); 4.1846 (0.6); 4.1674 (0.6); 4.1591 (0.7); 4.1419 (0.5); 3.7724 (0.8); 3.7639 (0.8); 3.7469 (0.7); 3.7382 (0.6); 3.3160 (2.2); 2.9689 (0.6); 2.9483 (0.6); 2.9259 (0.7); 2.9057 (0.7); 2.7984 (0.7); 2.7926 (0.6); 2.7796 (0.7); 2.5644 (0.7); 2.5540 (0.8); 2.5217 (2.2); 2.5087 (18.2); 2.5044 (35.2); 2.5000 (47.4); 2.4955 (34.3); 2.4910 (16.7); 2.3321 (0.5); 2.3227 (0.6); 2.1837 (2.2); 1.3572 (16.0); 1.0835 (1.5); 1.0655 (3.0); 1.0475 (1.4); 0.0079 (0.9); -0.0002 (19.6); -0.0084 (0.9) I.4-140:1H NMR (400.0MHz, d6-DMSO): δ= 9.2974 (0.6); 9.1280 (0.7); 9.1209 (0.7); 8.8690 (0.7); 8.8546 (0.7); 7.7300 (0.5); 7.7226 (0.6); 7.7147 (0.5); 7.7076 (0.5); 3.3106 (22.5); 3.1012 (1.3); 3.0848 (3.0); 3.0668 (3.0); 3.0491 (1.1); 2.6697 (0.5); 2.6247 (0.5); 2.5830 (0.6); 2.5097 (28.6); 2.5052 (59.6); 2.5007 (81.0); 2.4962 (57.0); 2.4917 (26.3); 1.2054 (7.7); 1.1872 (16.0); 1.1690 (7.4); 1.0809 (2.5); 1.0641 (4.8); 1.0473 (2.5); 0.0079 (1.1); -0.0002 (32.5); -0.0087 (1.1) I.4-141:1H NMR (400.0MHz, d6-DMSO): δ= 8.6358 (5.4); 8.4050 (6.1); 7.7035 (5.8); 7.6980 (2.1); 7.6911 (6.0); 7.6857 (3.4); 7.6804 (6.6); 7.6738 (2.2); 7.6680 (6.3); 7.4787 (0.7); 7.4585 (6.5); 7.4557 (8.0); 7.4368 (9.4); 7.4344 (8.4); 7.3925 (5.6); 7.3897 (7.2); 7.3709 (8.8); 7.3684 (7.9); 7.2947 (6.7); 7.2761 (8.8); 7.2550 (6.0); 7.2373 (12.3); 7.2322 (3.8); 7.2156 (16.0); 7.1978 (7.0); 7.1928 (6.8); 6.9821 (3.1); 6.9637 (5.3); 6.9453 (2.4); 6.9199 (2.8); 6.9015 (4.9); 6.8831 (2.2); 6.7300 (3.3); 6.7135 (3.3); 4.4004 (1.6); 4.3915 (1.7); 4.1479 (3.1); 4.1311 (3.2); 4.1227 (3.7); 4.1060 (3.1); 3.6820 (3.0); 3.6727 (2.8); 3.6570 (2.7); 3.6476 (2.6); 3.3453 (1.1); 3.3275 (1.4); 3.3122 (35.1); 2.9412 (3.1); 2.9214 (3.1); 2.8987 (3.6); 2.8789 (3.4); 2.6696 (0.8); 2.5095 (47.3); 2.5050 (100.9); 2.5005 (139.8); 2.4959 (100.0); 2.4914 (46.6); 2.4631 (3.2); 2.4517 (3.2); 2.4208 (2.6); 2.4090 (2.6); 2.3272 (0.9); 1.2353 (6.3); 1.1008 (1.2); 1.0831 (2.7); 1.0654 (1.3); 0.8538 (0.6); 0.0080 (1.4); -0.0002 (38.9); -0.0085 (1.3) I.5-1:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.2201 (6.9); 8.7836 (3.8); 7.9418 (2.9); 7.6727 (11.5); 7.6698 (14.2); 7.6507 (16.0); 7.6482 (13.6); 7.6213 (2.5); 7.6022 (2.5); 7.5340 (13.3); 7.5124 (15.7); 7.4075 (11.8); 7.3889 (15.2); 7.3674 (11.3); 7.2935 (4.5); 7.2780 (3.8); 7.1680 (6.1); 7.1495 (9.8); 7.1311 (4.3); 4.9235 (2.1); 4.2620 (5.2); 4.2456 (6.0); 4.2360 (6.5); 4.2193 (5.6); 3.7946 (3.6); 3.7753 (3.3); 3.3103 (443.5); 3.0661 (4.6); 3.0463 (4.9); 3.0231 (6.2); 3.0030 (5.0); 2.6741 (4.9); 2.6694 (7.5); 2.6650 (5.2); 2.5532 (4.5); 2.5229 (19.8); 2.5182 (30.2); 2.5096 (409.3); 2.5050 (881.5); 2.5004 (1225.5); 2.4958 (857.8); 2.4912 (387.8); 2.4511 (1.9); 2.3316 (5.3); 2.3273 (7.2); 2.3226 (5.0); 0.0079 (5.2); -0.0002 (164.3); -0.0087 (4.8) I.5-2:1H NMR (400.0MHz, d6-DMSO): δ= 9.2290 (4.3); 8.7822 (2.0); 8.7658 (2.0); 7.9321 (1.5); 7.7130 (0.6); 7.7039 (6.5); 7.6980 (2.2); 7.6915 (6.9); 7.6861 (3.5); 7.6806 (7.3); 7.6742 (2.3); 7.6683 (6.9); 7.6591 (0.6); 7.5355 (9.1); 7.5140 (10.9); 7.3027 (2.8); 7.2964 (2.7); 7.2811 (2.3); 7.2748 (2.3); 7.2590 (0.8); 7.2498 (7.4); 7.2440 (2.2); 7.2375 (1.0); 7.2323 (2.5); 7.2279 (10.2); 7.2226 (2.4); 7.2177 (0.9); 7.2110 (2.0); 7.2052 (6.5); 7.1960 (0.5); 5.7536 (10.4); 4.9251 (0.9); 4.2515 (3.0); 4.2350 (3.4); 4.2256 (3.8); 4.2091 (3.0); 4.0559 (1.0); 4.0382 (3.2); 4.0204 (3.2); 4.0026 (1.1); 3.7848 (2.0); 3.7771 (2.0); 3.7589 (1.8); 3.7514 (1.8); 3.3104 (106.0); 3.0552 (2.7); 3.0349 (3.0); 3.0121 (3.4); 2.9920 (3.0); 2.6742 (1.1); 2.6697 (1.5); 2.6650 (1.1); 2.6604 (0.5); 2.5541 (1.6); 2.5452 (1.9); 2.5231 (4.3); 2.5184 (6.6); 2.5098 (84.5); 2.5052 (181.9); 2.5006 (253.4); 2.4959 (175.6); 2.4914 (78.1); 2.4503 (0.6); 2.3367 (0.5); 2.3321 (1.1); 2.3273 (1.5); 2.3227 (1.1); 1.9880 (16.0); 1.2409 (0.5); 1.1923 (4.4); 1.1746 (8.7); 1.1568 (4.2); 0.8583 (0.9); 0.0081 (0.9); -0.0002 (30.6); -0.0086 (0.8) I.5-3:1H NMR (400.0MHz, d6-DMSO): δ= 9.2489 (6.6); 8.7537 (3.2); 8.7375 (3.0); 7.9037 (2.7); 7.5385 (13.3); 7.5170 (16.0); 7.4953 (6.6); 7.4896 (7.6); 7.4699 (7.5); 7.4644 (6.2); 7.3093 (4.4); 7.3026 (4.1); 7.2876 (4.0); 7.2810 (3.4); 7.0421 (2.5); 7.0246 (2.8); 7.0190 (4.6); 6.9962 (2.8); 4.9496 (1.7); 4.2414 (3.9); 4.2243 (4.3); 4.2149 (4.7); 4.1979 (4.3); 4.0383 (1.8); 4.0202 (1.8); 3.8064 (2.9); 3.7735 (2.8); 3.3594 (1.8); 3.3083 (609.9); 3.2576 (2.8); 3.1119 (4.0); 3.0915 (4.1); 3.0682 (4.4); 3.0481 (4.4); 2.6740 (6.0); 2.6693 (8.4); 2.6647 (6.0); 2.5986 (3.3); 2.5561 (4.0); 2.5228 (28.8); 2.5181 (42.2); 2.5095 (496.7); 2.5049 (1056.8); 2.5003 (1452.4); 2.4957 (1002.6); 2.4910 (442.6); 2.4548 (3.1); 2.4500 (4.2); 2.3317 (5.9); 2.3270 (8.5); 2.3225 (5.9); 2.0721 (2.0); 1.9877 (8.7); 1.2459 (2.4); 1.1922 (2.4); 1.1745 (4.8); 1.1567 (2.3); 0.8584 (4.1); 0.8410 (1.4); -0.0002 (50.0) I.5-5:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.2424 (3.5); 8.5766 (0.9); 7.6962 (1.0); 7.6688 (5.8); 7.6628 (5.7); 7.5022 (0.6); 7.4906 (2.9); 7.4849 (3.4); 7.4653 (3.5); 7.4597 (2.9); 7.4218 (3.4); 7.4157 (3.2); 7.4002 (3.0); 7.3941 (2.9); 7.0442 (0.6); 7.0389 (1.0); 7.0212 (1.2); 7.0154 (2.1); 7.0099 (1.0); 6.9981 (0.7); 6.9924 (1.1); 4.9746 (0.6); 4.2310 (1.7); 4.2136 (1.9); 4.2046 (2.2); 4.1873 (1.7); 4.0558 (1.0); 4.0380 (3.3); 4.0203 (3.3); 4.0024 (1.2); 3.7829 (1.2); 3.7749 (1.2); 3.7565 (1.1); 3.7490 (1.0); 3.3114 (79.6); 3.0911 (1.8); 3.0704 (2.0); 3.0476 (2.3); 3.0270 (2.0); 2.6743 (0.9); 2.6696 (1.3); 2.6651 (1.0); 2.5937 (1.1); 2.5847 (1.1); 2.5497 (1.5); 2.5401 (1.6); 2.5231 (4.2); 2.5185 (5.8); 2.5098 (75.4); 2.5052 (163.5); 2.5006 (227.6); 2.4959 (159.4); 2.4913 (71.0); 2.3319 (1.0); 2.3273 (1.3); 2.3227 (1.0); 1.9880 (16.0); 1.2462 (1.2); 1.1923 (4.4); 1.1745 (9.1); 1.1567 (4.5); 0.8754 (0.6); 0.8583 (2.4); 0.8407 (0.8); -0.0002 (8.6) I.5-6:1H NMR (400.0MHz, d6-DMSO): δ= 9.1549 (3.1); 8.3213 (0.6); 8.1436 (3.0); 8.1406 (3.2); 8.0287 (1.3); 8.0228 (1.3); 8.0199 (1.3); 8.0134 (2.0); 8.0090 (1.2); 8.0050 (1.4); 7.9992 (1.3); 7.6172 (0.7); 7.6140 (0.8); 7.6067 (6.1); 7.6045 (5.7); 7.5981 (2.8); 7.5948 (2.9); 7.5916 (3.3); 7.4133 (2.2); 7.2706 (2.0); 7.2499 (3.8); 7.2121 (2.7); 7.2066 (2.5); 7.1917 (1.3); 7.1862 (1.3); 5.7532 (12.9); 5.0027 (0.5); 4.2658 (1.4); 4.2485 (1.6); 4.2399 (1.8); 4.2227 (1.4); 4.0558 (0.6); 4.0381 (1.9); 4.0203 (1.9); 4.0025 (0.6); 3.8159 (1.1); 3.8072 (1.2); 3.7900 (1.1); 3.7813 (1.0); 3.3103 (74.5); 3.0631 (1.4); 3.0422 (1.6); 3.0197 (1.9); 2.9989 (1.7); 2.6740 (0.6); 2.6695 (0.9); 2.6648 (0.6); 2.6076 (1.2); 2.5972 (1.3); 2.5635 (1.5); 2.5528 (1.6); 2.5475 (1.3); 2.5228 (5.5); 2.5182 (6.9); 2.5095 (52.0); 2.5050 (107.5); 2.5004 (147.1); 2.4958 (103.8); 2.4912 (47.7); 2.4557 (0.9); 2.4511 (1.0); 2.4464 (0.8); 2.3318 (0.7); 2.3272 (0.9); 2.3226 (0.7); 2.1454 (16.0); 1.9878 (8.7); 1.2420 (1.9); 1.1923 (2.4); 1.1745 (4.7); 1.1567 (2.3); 0.8752 (0.7); 0.8583 (2.3); 0.8406 (1.0); -0.0002 (6.2) I.5-7:1H NMR (400.0MHz, d6-DMSO): δ= 9.1215 (2.8); 8.3354 (0.6); 7.6978 (3.5); 7.6919 (1.2); 7.6855 (3.8); 7.6800 (1.9); 7.6745 (4.1); 7.6681 (1.2); 7.6622 (3.8); 7.4298 (1.7); 7.2670 (2.0); 7.2460 (4.0); 7.2422 (4.4); 7.2362 (1.2); 7.2297 (0.6); 7.2246 (1.4); 7.2202 (5.4); 7.2148 (1.4); 7.2075 (2.8); 7.2023 (3.1); 7.1974 (3.8); 7.1873 (1.5); 7.1815 (1.3); 5.7533 (3.6); 4.2276 (1.5); 4.2104 (1.8); 4.2020 (2.0); 4.1848 (1.6); 3.7605 (1.1); 3.7521 (1.2); 3.7350 (1.0); 3.7265 (1.0); 3.3098 (40.4); 3.0132 (1.5); 2.9924 (1.7); 2.9702 (2.0); 2.9494 (1.8); 2.6694 (0.6); 2.5599 (0.9); 2.5494 (1.0); 2.5229 (2.1); 2.5181 (3.4); 2.5095 (34.5); 2.5050 (73.6); 2.5003 (102.0); 2.4957 (70.9); 2.4911 (31.3); 2.3272 (0.6); 2.1432 (16.0); -0.0002 (13.0) I.5-8:1H NMR (400.0MHz, d6-DMSO): δ= 9.2171 (3.0); 8.6059 (0.8); 8.5923 (0.8); 7.7078 (0.9); 7.6986 (4.4); 7.6928 (1.9); 7.6863 (4.3); 7.6809 (2.2); 7.6754 (4.3); 7.6689 (1.7); 7.6636 (7.8); 7.6580 (4.8); 7.4179 (3.1); 7.4118 (2.9); 7.3963 (2.7); 7.3902 (2.6); 7.2456 (4.2); 7.2398 (1.2); 7.2332 (0.6); 7.2281 (1.4); 7.2236 (5.9); 7.2183 (1.3); 7.2067 (1.1); 7.2009 (3.7); 5.7539 (16.0); 4.9410 (0.5); 4.2389 (1.7); 4.2219 (1.9); 4.2131 (2.2); 4.1962 (1.7); 4.0561 (0.7); 4.0382 (2.1); 4.0204 (2.2); 4.0026 (0.7); 3.7667 (1.1); 3.7586 (1.1); 3.7408 (1.0); 3.7333 (1.0); 3.3122 (36.2); 3.0340 (1.6); 3.0135 (1.8); 2.9910 (2.1); 2.9706 (1.8); 2.6698 (0.6); 2.5532 (0.9); 2.5440 (1.0); 2.5233 (1.7); 2.5186 (2.6); 2.5099 (32.0); 2.5054 (68.2); 2.5007 (94.9); 2.4961 (65.7); 2.4916 (29.2); 2.3275 (0.6); 1.9881 (10.4); 1.2965 (0.6); 1.2791 (1.5); 1.2667 (1.8); 1.2581 (2.5); 1.2475 (7.1); 1.1924 (3.0); 1.1746 (6.0); 1.1568 (2.9); 0.8752 (3.6); 0.8583 (14.1); 0.8407 (4.8); -0.0002 (13.6) I.5-9:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.1522 (2.7); 8.3087 (0.6); 7.5024 (0.5); 7.4907 (2.6); 7.4850 (3.0); 7.4653 (3.1); 7.4597 (2.5); 7.4113 (2.1); 7.4069 (2.2); 7.2714 (2.0); 7.2506 (3.8); 7.2134 (2.8); 7.2079 (2.5); 7.1929 (1.4); 7.1874 (1.3); 7.0382 (0.5); 7.0325 (0.8); 7.0152 (1.0); 7.0095 (1.6); 7.0037 (0.9); 6.9921 (0.6); 6.9863 (0.8); 4.2207 (1.4); 4.2031 (1.6); 4.1945 (1.8); 4.1770 (1.5); 3.7728 (1.1); 3.7641 (1.1); 3.7465 (1.0); 3.7382 (1.0); 3.3102 (45.2); 3.3091 (44.5); 3.0703 (1.5); 3.0492 (1.7); 3.0268 (2.0); 3.0058 (1.7); 2.6742 (0.6); 2.6694 (0.8); 2.6648 (0.6); 2.5986 (1.0); 2.5884 (1.0); 2.5556 (0.9); 2.5441 (0.8); 2.5229 (2.9); 2.5182 (4.1); 2.5096 (50.3); 2.5050 (108.1); 2.5004 (150.2); 2.4958 (104.8); 2.4912 (46.7); 2.3318 (0.6); 2.3272 (0.9); 2.3226 (0.6); 2.1440 (16.0); -0.0002 (6.5) I.5-11:1H NMR (400.0MHz, CDCl3): δ= 7.6625 (6.0); 7.6076 (4.2); 7.5716 (2.4); 7.5487 (2.3); 7.5381 (2.0); 7.5180 (16.0); 7.4941 (15.0); 7.4346 (2.4); 7.4098 (5.9); 7.3897 (6.6); 7.3683 (4.3); 7.3627 (3.6); 7.3459 (4.0); 7.3192 (15.9); 7.2968 (13.7); 7.2903 (5.5); 7.2832 (4.2); 7.2801 (4.6); 7.2793 (4.4); 7.2784 (4.6); 7.2769 (4.4); 7.2761 (4.7); 7.2753 (5.0); 7.2745 (5.3); 7.2737 (5.5); 7.2729 (5.9); 7.2720 (6.5); 7.2713 (7.2); 7.2704 (7.9); 7.2680 (14.4); 7.2593 (1102.6); 7.2495 (11.3); 7.2487 (11.0); 7.2479 (10.4); 7.2471 (9.8); 7.2463 (9.7); 7.2455 (9.5); 7.2439 (9.3); 7.2335 (10.7); 7.2257 (10.4); 7.2093 (16.7); 7.1171 (1.4); 7.0607 (1.0); 6.9953 (6.8); 6.4725 (2.2); 5.1541 (2.4); 4.2952 (2.9); 4.2799 (3.3); 4.2674 (3.8); 4.2523 (3.7); 4.1625 (0.8); 4.1470 (1.1); 4.1367 (1.1); 4.1296 (1.8); 4.1119 (1.7); 3.9511 (3.9); 3.9243 (3.9); 3.1435 (3.2); 3.1230 (3.2); 3.0993 (3.9); 3.0784 (3.9); 2.9881 (0.8); 2.9694 (0.9); 2.5423 (2.9); 2.4923 (2.5); 2.0427 (6.9); 2.0037 (0.9); 1.5534 (46.1); 1.2758 (3.4); 1.2579 (6.1); 1.2400 (2.7); 0.8989 (1.6); 0.8820 (5.0); 0.8644 (2.0); 0.4368 (1.2); 0.3305 (1.0); 0.2373 (1.6); 0.1568 (2.7); 0.1464 (1.6); 0.1263 (0.9); 0.0501 (1.8); 0.0080 (15.0); -0.0002 (436.7); -0.0085 (16.3); -0.0499 (5.4); -0.1494 (1.8) I.5-12:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.1137 (2.2); 8.3451 (0.6); 7.6662 (3.8); 7.6633 (4.7); 7.6442 (5.2); 7.6416 (4.4); 7.4426 (1.7); 7.4005 (3.6); 7.3954 (1.3); 7.3820 (4.6); 7.3791 (3.7); 7.3604 (3.7); 7.2651 (1.9); 7.2444 (3.4); 7.2046 (2.4); 7.1989 (2.2); 7.1841 (1.3); 7.1785 (1.2); 7.1612 (1.9); 7.1585 (1.1); 7.1427 (3.1); 7.1243 (1.4); 5.7538 (0.8); 4.9559 (0.5); 4.2378 (1.6); 4.2208 (1.8); 4.2121 (2.0); 4.1951 (1.6); 3.7789 (1.2); 3.7701 (1.1); 3.7525 (1.1); 3.7442 (1.0); 3.3107 (103.6); 3.0234 (1.6); 3.0029 (1.8); 2.9805 (2.0); 2.9600 (1.8); 2.6740 (1.2); 2.6694 (1.7); 2.6648 (1.2); 2.5695 (1.1); 2.5604 (1.0); 2.5229 (5.2); 2.5181 (7.4); 2.5095 (96.8); 2.5049 (212.2); 2.5003 (297.5); 2.4957 (208.0); 2.4911 (93.4); 2.3317 (1.2); 2.3271 (1.7); 2.3225 (1.3); 2.1432 (16.0); 1.9878 (1.5); 1.1743 (0.8); 0.0079 (1.2); -0.0002 (43.5); -0.0086 (1.4) I.5-13:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.2085 (4.3); 8.6230 (1.5); 7.7032 (1.7); 7.6669 (8.9); 7.6640 (11.9); 7.6622 (11.5); 7.6554 (7.5); 7.6450 (11.3); 7.6424 (9.4); 7.4151 (5.1); 7.4089 (5.6); 7.4034 (8.6); 7.3981 (2.9); 7.3934 (5.0); 7.3850 (11.0); 7.3633 (8.1); 7.1642 (4.1); 7.1458 (6.6); 7.1274 (3.0); 5.7538 (16.0); 4.9260 (1.2); 4.2481 (3.3); 4.2313 (3.7); 4.2220 (4.2); 4.2055 (3.5); 3.7765 (2.2); 3.7581 (2.1); 3.7501 (2.1); 3.3114 (268.8); 3.3101 (264.4); 3.2586 (1.0); 3.0436 (2.9); 3.0233 (3.2); 3.0006 (3.8); 2.9801 (3.4); 2.6742 (3.2); 2.6695 (4.4); 2.6648 (3.3); 2.5630 (2.1); 2.5229 (12.3); 2.5182 (18.3); 2.5095 (265.4); 2.5049 (583.8); 2.5003 (820.6); 2.4957 (575.5); 2.4911 (260.0); 2.4495 (2.6); 2.3318 (3.3); 2.3271 (4.9); 2.3226 (3.5); 1.2494 (0.9); 0.8583 (1.3); 0.0080 (3.0); -0.0002 (114.0); -0.0085 (3.5) I.5-14:1H NMR (400.0MHz, CDCl3): δ= 7.5220 (10.8); 7.5175 (15.6); 7.5030 (5.7); 7.4816 (7.0); 7.3587 (3.2); 7.3410 (8.3); 7.3356 (6.6); 7.3200 (7.7); 7.2591 (1451.9); 7.1844 (3.5); 7.1653 (7.7); 7.1452 (3.5); 6.9951 (8.2); 6.3306 (2.3); 4.2424 (2.9); 4.2272 (2.9); 4.2153 (3.5); 4.2006 (3.0); 4.1304 (3.1); 4.1123 (3.9); 3.8812 (3.4); 3.8526 (2.9); 3.0851 (3.2); 3.0657 (3.5); 3.0403 (3.7); 3.0220 (3.5); 2.5152 (2.9); 2.4643 (2.8); 2.0434 (16.0); 1.5284 (77.9); 1.2764 (5.9); 1.2586 (10.0); 1.2406 (4.6); 0.8821 (4.9); 0.0080 (23.0); -0.0002 (598.4); -0.0085 (19.7) I.5-15:1H NMR (400.0MHz, d6-DMSO): δ= 9.2028 (2.2); 8.5827 (0.9); 8.5660 (0.9); 7.9203 (0.6); 7.5360 (3.9); 7.5144 (4.6); 7.3008 (1.2); 7.2945 (1.2); 7.2792 (1.0); 7.2729 (1.0); 5.7519 (0.8); 4.1900 (1.1); 4.1730 (1.5); 4.1560 (1.1); 3.6776 (1.1); 3.6607 (1.2); 3.6519 (1.3); 3.6351 (1.2); 3.3063 (39.3); 3.2269 (1.0); 3.2180 (1.0); 3.2013 (0.9); 3.1924 (0.9); 2.7346 (1.3); 2.7140 (1.4); 2.6925 (1.7); 2.6718 (1.6); 2.5228 (1.1); 2.5181 (1.5); 2.5095 (21.8); 2.5049 (47.6); 2.5003 (66.8); 2.4957 (46.9); 2.4911 (21.4); 2.2794 (0.5); 2.2699 (0.5); 1.0861 (8.6); 1.0695 (16.0); 1.0530 (8.5); -0.0002 (2.1) I.5-16:1H NMR (400.0MHz, d6-DMSO): δ= 9.2522 (3.0); 8.8288 (1.7); 8.8118 (1.7); 7.9403 (0.8); 7.5499 (5.8); 7.5451 (1.9); 7.5349 (6.4); 7.5286 (6.8); 7.5134 (6.2); 7.3008 (1.4); 7.2948 (1.4); 7.2795 (1.2); 7.2732 (1.1); 7.1991 (4.8); 7.1786 (4.4); 5.7574 (0.6); 4.9022 (0.6); 4.2285 (1.6); 4.2120 (1.9); 4.2024 (2.1); 4.1860 (1.7); 3.7603 (1.1); 3.7406 (1.0); 3.4059 (132.8); 3.3562 (2.0); 3.1222 (0.6); 3.1100 (0.6); 3.1038 (1.9); 3.0918 (1.9); 3.0856 (2.0); 3.0736 (1.9); 3.0675 (0.6); 3.0554 (0.6); 3.0438 (1.5); 3.0236 (1.6); 3.0009 (1.9); 2.9807 (1.6); 2.6754 (0.8); 2.6709 (1.2); 2.6664 (0.9); 2.5244 (3.6); 2.5197 (4.7); 2.5110 (54.4); 2.5064 (119.3); 2.5018 (166.6); 2.4972 (116.8); 2.4926 (51.7); 2.4566 (1.5); 2.4519 (1.9); 2.4474 (1.3); 2.3332 (0.9); 2.3286 (1.3); 2.3239 (0.9); 2.2813 (16.0); 2.0744 (0.6); 1.1987 (3.6); 1.1805 (7.6); 1.1622 (3.5); -0.0002 (0.9) I.5-17:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.1984 (4.4); 8.6297 (1.7); 8.6137 (1.7); 7.9274 (0.8); 7.5352 (6.9); 7.5136 (8.1); 7.3007 (1.7); 7.2945 (1.7); 7.2790 (1.4); 7.2727 (1.4); 5.7537 (3.2); 4.7744 (0.7); 4.0380 (0.8); 4.0202 (0.8); 3.7237 (2.1); 3.7069 (2.3); 3.6977 (2.6); 3.6810 (2.2); 3.3103 (117.3); 3.2980 (2.1); 3.2806 (1.5); 3.2720 (1.5); 3.2602 (1.0); 3.0166 (2.8); 3.0064 (2.9); 2.9980 (3.2); 2.9878 (2.9); 2.9733 (0.5); 2.7735 (1.5); 2.7530 (1.7); 2.7313 (2.0); 2.7108 (1.8); 2.6740 (0.8); 2.6695 (1.2); 2.6649 (0.8); 2.5230 (2.7); 2.5183 (3.9); 2.5096 (60.5); 2.5050 (134.8); 2.5003 (190.2); 2.4957 (131.7); 2.4911 (58.0); 2.4550 (1.4); 2.4504 (1.7); 2.4458 (1.1); 2.3318 (0.9); 2.3272 (1.2); 2.3225 (0.9); 2.2985 (0.8); 2.2483 (0.7); 1.9878 (3.8); 1.8830 (0.6); 1.8648 (1.2); 1.8479 (1.6); 1.8313 (1.3); 1.8139 (0.6); 1.1922 (1.1); 1.1745 (2.3); 1.1567 (1.2); 0.8583 (0.8); 0.8450 (15.0); 0.8344 (16.0); 0.8284 (15.5); 0.8178 (14.9); 0.0079 (3.6); 0.0063 (0.8); 0.0054 (1.0); 0.0046 (1.2); 0.0037 (1.7); 0.0021 (5.2); -0.0002 (132.1); -0.0028 (5.9); -0.0044 (2.0); -0.0052 (1.5); - 0.0061 (1.2); -0.0069 (1.1); -0.0085 (3.8); -0.0108 (0.6); -0.0116 (0.5); -0.0503 (0.9) I.5-18:1H NMR (400.0MHz, d6-DMSO): δ= 9.2304 (1.6); 8.7993 (0.8); 8.7828 (0.8); 7.5665 (3.0); 7.5608 (1.0); 7.5492 (1.2); 7.5436 (3.4); 7.5357 (2.3); 7.5142 (2.5); 7.3011 (0.7); 7.2953 (0.7); 7.2797 (0.6); 7.2733 (0.6); 6.9614 (3.3); 6.9558 (1.0); 6.9385 (3.0); 4.2184 (0.7); 4.2018 (0.8); 4.1924 (1.0); 4.1759 (0.8); 3.7437 (16.0); 3.7220 (0.6); 3.3168 (106.8); 3.2668 (0.9); 3.0996 (0.5); 3.0940 (0.5); 3.0817 (0.5); 3.0241 (0.7); 3.0038 (0.7); 2.9811 (0.8); 2.9615 (0.7); 2.6745 (0.6); 2.6696 (0.7); 2.6652 (0.6); 2.5232 (3.6); 2.5097 (44.3); 2.5052 (90.4); 2.5007 (122.9); 2.4961 (87.1); 2.4916 (40.2); 2.4553 (1.1); 2.4507 (1.4); 2.4461 (1.1); 2.3276 (0.8); 1.1947 (1.2); 1.1765 (2.3); 1.1583 (1.1); 0.0080 (1.7); -0.0002 (58.1); -0.0085 (2.3); -0.0501 (0.5) I.5-19: 1H NMR (400.0 MHz, d6-DMSO): δ= 9.2094 (10.0); 8.6074 (3.8); 8.5906 (3.7); 7.9225 (1.9); 7.7580 (2.2); 7.7517 (2.3); 7.6757 (2.3); 7.6539 (2.9); 7.5590 (0.6); 7.5362 (13.5); 7.5147 (16.0); 7.4912 (2.1); 7.4850 (2.0); 7.4694 (1.6); 7.4632 (1.6); 7.3013 (3.9); 7.2950 (3.8); 7.2798 (3.2); 7.2734 (3.1); 5.7529 (1.5); 4.7815 (1.4); 4.3877 (0.6); 4.3687 (2.4); 4.3495 (3.5); 4.3296 (2.1); 4.3101 (0.6); 3.7125 (3.8); 3.6956 (4.2); 3.6867 (4.7); 3.6699 (4.0); 3.3510 (0.8); 3.3169 (349.3); 3.2666 (2.8); 3.2566 (3.4); 3.2482 (3.4); 3.2310 (2.9); 3.2226 (3.2); 3.1985 (0.6); 3.1123 (0.7); 3.1007 (0.8); 3.0943 (0.7); 3.0824 (0.8); 2.7464 (4.1); 2.7258 (4.6); 2.7042 (5.4); 2.6836 (4.8); 2.6751 (0.9); 2.6704 (0.9); 2.6657 (0.7); 2.5238 (2.5); 2.5191 (3.7); 2.5105 (45.5); 2.5059 (98.1); 2.5013 (137.1); 2.4967 (97.4); 2.4921 (45.3); 2.4559 (1.0); 2.4512 (1.2); 2.4468 (1.0); 2.4057 (0.5); 2.3326 (0.7); 2.3280 (1.0); 2.3234 (0.7); 2.2739 (1.8); 2.2314 (1.6); 1.7437 (1.3); 1.7205 (2.6); 1.7082 (3.3); 1.6898 (3.1); 1.6717 (2.5); 1.6567 (3.6); 1.6500 (3.8); 1.6434 (4.6); 1.6305 (3.1); 1.6088 (1.3); 1.5493 (3.2); 1.5428 (3.8); 1.5314 (6.0); 1.5154 (7.5); 1.4944 (3.7); 1.4755 (2.3); 1.1961 (2.0); 1.1779 (4.0); 1.1597 (1.9); -0.0002 (1.1) I.5-20:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.2442 (4.1); 8.7625 (1.9); 8.7464 (1.9); 7.9027 (6.0); 7.8968 (3.2); 7.8857 (3.6); 7.8798 (16.0); 7.8606 (15.8); 7.8546 (2.8); 7.8433 (1.9); 7.8377 (4.4); 7.5340 (7.6); 7.5123 (9.1); 7.3059 (2.6); 7.2996 (2.5); 7.2848 (2.1); 7.2781 (2.1); 5.7512 (6.7); 4.9566 (0.9); 4.2936 (2.2); 4.2769 (2.6); 4.2674 (2.8); 4.2508 (2.2); 4.0563 (0.6); 4.0384 (1.6); 4.0205 (1.6); 4.0027 (0.5); 3.8516 (1.8); 3.8443 (1.8); 3.8261 (1.6); 3.8185 (1.6); 3.3561 (0.6); 3.3375 (0.8); 3.3023 (299.6); 3.2732 (1.0); 3.1225 (2.3); 3.1023 (2.5); 3.0791 (2.8); 3.0588 (2.4); 2.6736 (2.6); 2.6689 (3.7); 2.6643 (2.7); 2.6597 (1.3); 2.6106 (1.6); 2.5659 (1.2); 2.5329 (2.2); 2.5225 (11.2); 2.5177 (16.2); 2.5091 (211.3); 2.5045 (452.6); 2.4999 (627.8); 2.4953 (436.1); 2.4907 (195.0); 2.4686 (1.7); 2.4639 (1.2); 2.4593 (0.8); 2.3313 (2.7); 2.3267 (3.7); 2.3220 (2.6); 2.0713 (0.5); 1.9873 (7.7); 1.1924 (2.0); 1.1746 (4.1); 1.1568 (2.0); -0.0002 (15.7) I.5-22:1H NMR (400.0MHz, d6-DMSO): δ= 9.2370 (5.5); 8.5857 (1.4); 7.8976 (4.5); 7.8917 (2.1); 7.8806 (3.3); 7.8747 (16.0); 7.8562 (15.9); 7.8504 (3.2); 7.8389 (1.9); 7.8334 (4.4); 7.6934 (1.5); 7.6628 (7.8); 7.6568 (7.7); 7.4178 (4.5); 7.4117 (4.2); 7.3962 (3.8); 7.3902 (3.8); 4.9713 (1.0); 4.2826 (2.2); 4.2655 (2.7); 4.2566 (3.0); 4.2395 (2.3); 4.0558 (0.7); 4.0382 (2.4); 4.0204 (2.5); 4.0027 (0.8); 3.8291 (1.7); 3.8215 (1.9); 3.8033 (1.7); 3.3050 (249.4); 3.2566 (0.7); 3.1025 (2.3); 3.0818 (2.7); 3.0589 (3.0); 3.0384 (2.7); 2.6738 (2.2); 2.6691 (3.2); 2.6646 (2.3); 2.6135 (1.6); 2.6033 (1.6); 2.5603 (1.9); 2.5225 (9.7); 2.5178 (14.7); 2.5092 (180.8); 2.5046 (386.7); 2.5000 (533.6); 2.4955 (379.6); 2.4909 (174.7); 2.4468 (0.8); 2.3314 (2.3); 2.3267 (3.2); 2.3222 (2.3); 2.0718 (0.7); 1.9875 (11.1); 1.2485 (1.1); 1.1923 (3.2); 1.1745 (6.6); 1.1567 (3.1); 0.8750 (0.5); 0.8584 (1.7); 0.8411 (0.6); -0.0002 (15.5) I.5-23:1H NMR (400.0MHz, d6-DMSO): δ= 9.1369 (16.0); 8.3689 (4.4); 8.3520 (4.4); 7.6901 (2.8); 7.6716 (3.0); 7.6550 (3.3); 7.6507 (2.6); 7.6472 (2.4); 7.6386 (2.3); 7.6371 (2.5); 7.6316 (2.9); 7.5820 (0.5); 7.5703 (2.5); 7.5648 (2.2); 7.5633 (1.9); 7.5547 (2.1); 7.5512 (2.2); 7.5465 (3.0); 7.5359 (0.5); 7.5005 (11.9); 7.4968 (12.1); 7.4806 (14.4); 7.4769 (14.4); 7.4465 (1.1); 7.4414 (1.6); 7.4374 (0.9); 7.4277 (4.4); 7.4227 (4.8); 7.4190 (4.4); 7.4113 (8.1); 7.4038 (3.3); 7.4003 (4.1); 7.3951 (3.2); 7.3815 (1.2); 7.3763 (0.8); 7.3395 (5.7); 7.3357 (6.1); 7.3208 (10.5); 7.3170 (10.0); 7.3011 (8.3); 7.2972 (7.6); 7.2482 (6.0); 7.2441 (6.1); 7.2287 (7.8); 7.2249 (7.7); 7.2097 (3.7); 7.2057 (3.5); 5.7526 (3.2); 4.7941 (2.2); 4.5737 (1.2); 4.5560 (1.2); 4.3870 (1.0); 4.3677 (4.1); 4.3486 (6.1); 4.3287 (3.5); 4.3092 (1.0); 4.1252 (0.6); 4.1075 (0.6); 3.7028 (6.3); 3.6856 (7.1); 3.6773 (7.9); 3.6602 (6.8); 3.3460 (0.6); 3.3171 (495.1); 3.2939 (1.2); 3.2853 (1.3); 3.2811 (0.7); 3.2669 (3.7); 3.2505 (5.6); 3.2412 (5.7); 3.2263 (5.5); 3.2161 (5.3); 3.1980 (1.0); 2.7249 (8.3); 2.7042 (9.3); 2.6828 (11.0); 2.6748 (1.2); 2.6700 (1.5); 2.6621 (9.8); 2.5235 (2.8); 2.5188 (4.0); 2.5102 (60.0); 2.5056 (132.8); 2.5009 (187.4); 2.4963 (130.3); 2.4917 (57.7); 2.4554 (1.4); 2.4508 (1.6); 2.4462 (1.3); 2.4417 (0.8); 2.4104 (0.6); 2.4058 (0.6); 2.3368 (0.5); 2.3324 (1.0); 2.3277 (1.4); 2.3232 (1.0); 2.2900 (3.1); 2.2803 (3.2); 2.2484 (2.6); 2.2379 (2.6); 1.7391 (2.1); 1.7276 (3.3); 1.7199 (4.4); 1.7052 (5.4); 1.6978 (5.0); 1.6881 (4.8); 1.6825 (4.9); 1.6694 (4.2); 1.6551 (5.9); 1.6487 (6.2); 1.6424 (7.4); 1.6273 (5.0); 1.6072 (2.0); 1.5699 (2.1); 1.5477 (5.0); 1.5386 (6.0); 1.5300 (9.3); 1.5167 (11.5); 1.5128 (12.3); 1.4926 (5.5); 1.4734 (3.5); 1.3402 (1.4); 1.3225 (3.0); 1.3048 (1.4); 1.2509 (0.7); 1.2331 (1.6); 1.2154 (0.7); 1.1943 (0.7); 1.1761 (1.3); 1.1578 (0.8); 1.1544 (1.6); 1.1367 (3.2); 1.1190 (1.4); -0.0002 (1.8) I.5-24:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.3900 (4.8); 9.3774 (1.9); 8.5873 (1.1); 8.0105 (0.6); 7.8894 (2.9); 7.8832 (3.2); 7.5575 (8.0); 7.5359 (10.0); 7.5301 (5.0); 7.5146 (1.6); 7.5085 (6.6); 7.5031 (4.0); 7.4973 (4.7); 7.4778 (4.3); 7.4721 (3.4); 7.3331 (2.4); 7.3268 (2.4); 7.3116 (2.2); 7.3053 (2.2); 7.3019 (2.6); 7.2954 (2.3); 7.2803 (2.2); 7.2738 (1.9); 7.0451 (0.9); 7.0394 (1.5); 7.0220 (1.8); 7.0163 (2.9); 7.0105 (1.4); 6.9932 (1.5); 4.7183 (0.7); 4.2475 (2.0); 4.2287 (2.2); 4.2224 (2.3); 4.2036 (1.9); 4.0558 (0.6); 4.0381 (1.8); 4.0203 (1.9); 4.0025 (0.7); 3.6492 (2.2); 3.6332 (2.2); 3.6240 (2.0); 3.6083 (1.9); 3.3608 (0.6); 3.3104 (278.1); 3.2603 (1.9); 2.8269 (0.9); 2.8103 (1.3); 2.7918 (0.9); 2.6742 (1.9); 2.6696 (2.6); 2.6648 (1.8); 2.5510 (0.6); 2.5230 (6.8); 2.5184 (9.3); 2.5097 (138.6); 2.5051 (308.8); 2.5004 (435.4); 2.4958 (303.0); 2.4912 (134.8); 2.4664 (1.4); 2.4596 (1.9); 2.4551 (2.7); 2.4505 (3.3); 2.4457 (2.5); 2.4004 (0.8); 2.3319 (2.0); 2.3273 (2.7); 2.3225 (2.0); 1.9879 (8.9); 1.2524 (16.0); 1.2344 (15.7); 1.1961 (1.2); 1.1923 (3.1); 1.1745 (5.5); 1.1567 (2.7); 1.1432 (1.7); 1.1246 (1.8); 0.8752 (0.9); 0.8584 (4.0); 0.8407 (1.4); 0.1458 (0.7); 0.0080 (6.4); 0.0055 (1.3); 0.0047 (1.6); -0.0002 (240.1); -0.0051 (3.8); -0.0059 (3.2); -0.0068 (2.8); -0.0085 (7.4); -0.0503 (1.7); -0.1495 (0.8) I.5-25:1H NMR (400.0MHz, d6-DMSO): δ= 9.1671 (3.1); 8.5717 (1.1); 8.5560 (1.1); 7.7082 (0.7); 7.6890 (0.7); 7.5567 (0.6); 7.5532 (1.1); 7.5470 (5.8); 7.5423 (1.8); 7.5304 (2.0); 7.5257 (6.5); 7.5194 (0.8); 7.4982 (2.6); 7.4946 (2.6); 7.4783 (3.1); 7.4746 (3.0); 7.4284 (0.7); 7.4233 (0.7); 7.4197 (0.7); 7.4121 (1.2); 7.4010 (0.6); 7.3390 (1.2); 7.3352 (1.2); 7.3202 (2.2); 7.3165 (2.1); 7.3005 (1.7); 7.2967 (1.6); 7.2461 (1.3); 7.2420 (1.3); 7.2265 (1.7); 7.2228 (1.7); 7.2075 (1.0); 7.2036 (1.3); 7.1958 (4.8); 7.1754 (4.3); 5.7553 (0.5); 4.9352 (0.5); 4.2175 (1.6); 4.2006 (1.9); 4.1916 (2.1); 4.1748 (1.7); 3.7571 (1.1); 3.7491 (1.1); 3.7314 (1.0); 3.7236 (1.0); 3.3676 (0.6); 3.3175 (134.2); 3.2672 (0.9); 3.0224 (1.6); 3.0019 (1.8); 2.9795 (2.1); 2.9591 (1.8); 2.6698 (0.6); 2.5460 (1.1); 2.5365 (0.9); 2.5233 (1.7); 2.5186 (2.4); 2.5099 (36.2); 2.5053 (80.0); 2.5007 (112.5); 2.4961 (78.5); 2.4915 (35.0); 2.4552 (0.7); 2.4506 (1.0); 2.4459 (0.7); 2.3321 (0.6); 2.3275 (0.7); 2.3228 (0.5); 2.2802 (16.0); 1.9882 (1.0); 1.1921 (0.9); 1.1743 (1.7); 1.1564 (0.8); 1.1359 (0.5); 0.0080 (1.8); 0.0046 (0.6); -0.0002 (72.0); -0.0052 (1.2); -0.0060 (0.9); -0.0069 (0.8); -0.0085 (2.2); -0.0503 (0.6) I.5-26:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.1835 (4.9); 8.5556 (1.5); 8.5392 (1.5); 7.7276 (1.2); 7.7196 (11.4); 7.7141 (3.6); 7.7024 (4.3); 7.6968 (14.8); 7.6888 (2.3); 7.6769 (1.2); 7.6550 (0.8); 7.6508 (0.7); 7.6472 (0.7); 7.6387 (0.6); 7.6371 (0.6); 7.6312 (0.7); 7.5701 (0.6); 7.5547 (0.5); 7.5511 (0.6); 7.5467 (0.7); 7.5461 (0.7); 7.5005 (4.0); 7.4968 (4.1); 7.4806 (4.9); 7.4769 (4.8); 7.4584 (1.4); 7.4503 (14.3); 7.4448 (3.9); 7.4413 (0.9); 7.4395 (0.8); 7.4331 (3.5); 7.4276 (13.4); 7.4225 (1.6); 7.4190 (1.7); 7.4112 (1.9); 7.4036 (0.8); 7.4002 (1.1); 7.3949 (0.8); 7.3421 (1.9); 7.3383 (2.0); 7.3234 (3.6); 7.3196 (3.4); 7.3037 (2.8); 7.2998 (2.6); 7.2505 (2.1); 7.2465 (2.2); 7.2310 (2.7); 7.2272 (2.7); 7.2121 (1.3); 7.2081 (1.2); 5.7551 (12.8); 4.9594 (0.8); 4.2406 (2.5); 4.2236 (2.9); 4.2147 (3.2); 4.1978 (2.6); 4.0561 (1.1); 4.0382 (3.4); 4.0204 (3.4); 4.0026 (1.1); 3.7806 (1.8); 3.7725 (1.8); 3.7548 (1.6); 3.7467 (1.6); 3.3222 (83.2); 3.2723 (0.7); 3.0531 (2.6); 3.0326 (2.9); 3.0100 (3.3); 2.9895 (2.9); 2.5752 (1.4); 2.5653 (1.4); 2.5319 (1.3); 2.5239 (1.8); 2.5195 (1.9); 2.5107 (15.5); 2.5061 (34.2); 2.5015 (48.1); 2.4968 (33.6); 2.4923 (14.9); 1.9887 (16.0); 1.3235 (0.8); 1.1925 (4.8); 1.1747 (9.4); 1.1569 (4.7); 1.1368 (0.9); -0.0002 (4.6) I.5-27:1H NMR (400.0MHz, d6-DMSO): δ= 9.1289 (4.4); 8.4001 (1.4); 8.3830 (1.4); 7.6788 (0.9); 7.4988 (3.1); 7.4951 (3.2); 7.4789 (3.7); 7.4752 (3.7); 7.3385 (1.5); 7.3348 (1.6); 7.3197 (2.9); 7.3160 (2.8); 7.3001 (2.1); 7.2963 (1.9); 7.2461 (1.6); 7.2421 (1.7); 7.2266 (2.2); 7.2230 (2.2); 7.2076 (1.0); 7.2038 (1.0); 5.7534 (3.5); 4.7886 (0.8); 3.7134 (2.0); 3.6964 (2.2); 3.6877 (2.5); 3.6707 (2.2); 3.3122 (146.8); 3.2927 (2.7); 3.2757 (1.9); 3.2666 (1.7); 3.2615 (1.6); 3.0494 (0.7); 3.0307 (0.8); 3.0161 (3.0); 2.9979 (5.4); 2.9801 (2.9); 2.9652 (0.8); 2.9468 (0.7); 2.7508 (1.7); 2.7300 (1.9); 2.7086 (2.3); 2.6879 (2.1); 2.6741 (0.6); 2.6696 (0.8); 2.6646 (0.5); 2.5229 (2.4); 2.5182 (3.5); 2.5096 (41.6); 2.5050 (89.9); 2.5004 (125.6); 2.4959 (90.5); 2.4913 (43.4); 2.4590 (0.8); 2.4544 (1.1); 2.4499 (1.3); 2.4453 (1.0); 2.3319 (0.7); 2.3273 (0.9); 2.3224 (0.7); 2.3089 (1.0); 2.2999 (1.0); 2.2651 (0.8); 2.2564 (0.8); 1.8798 (0.7); 1.8621 (1.3); 1.8453 (1.8); 1.8284 (1.4); 1.8113 (0.7); 0.8430 (15.0); 0.8345 (16.0); 0.8264 (15.6); 0.8179 (15.3); 0.0080 (0.6); -0.0002 (21.1); - 0.0085 (0.8) I.5-28:1H NMR (400.0MHz, d6-DMSO): δ= 9.0832 (2.5); 8.1155 (0.6); 7.4065 (1.5); 7.2678 (1.8); 7.2471 (3.4); 7.2077 (2.4); 7.2022 (2.3); 7.1870 (1.1); 7.1819 (1.2); 4.1997 (0.5); 4.1824 (1.4); 4.1655 (1.9); 4.1487 (1.4); 3.6560 (1.2); 3.6384 (1.3); 3.6304 (1.4); 3.6130 (1.3); 3.3365 (1.0); 3.3047 (224.7); 3.2026 (1.4); 3.1928 (1.6); 3.1775 (1.3); 3.1674 (1.2); 2.6863 (1.6); 2.6737 (1.7); 2.6690 (2.5); 2.6649 (3.0); 2.6443 (2.0); 2.6233 (1.6); 2.5225 (6.6); 2.5178 (9.0); 2.5092 (128.3); 2.5046 (280.3); 2.5000 (393.6); 2.4953 (276.4); 2.4908 (125.8); 2.4495 (0.6); 2.3866 (0.6); 2.3360 (0.8); 2.3314 (1.8); 2.3267 (2.4); 2.3222 (1.7); 2.2962 (1.0); 2.2840 (0.9); 2.2539 (1.0); 2.2423 (0.8); 2.1401 (16.0); 1.0737 (10.5); 1.0650 (11.0); 1.0568 (10.8); 1.0481 (11.0); - 0.0002 (1.5) I.5-29:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.1654 (1.2); 7.5638 (2.8); 7.5581 (0.9); 7.5466 (0.9); 7.5408 (3.1); 7.5004 (1.0); 7.4966 (1.0); 7.4804 (1.2); 7.4767 (1.2); 7.3218 (0.8); 7.3180 (0.8); 7.3021 (0.7); 7.2982 (0.6); 7.2475 (0.5); 7.2434 (0.5); 7.2276 (0.7); 6.9592 (3.1); 6.9535 (0.9); 6.9420 (0.9); 6.9363 (2.8); 4.2074 (0.6); 4.1905 (0.8); 4.1815 (0.8); 4.1648 (0.7); 3.7431 (16.0); 3.3666 (0.5); 3.3166 (111.2); 3.2665 (1.1); 3.0034 (0.6); 2.9829 (0.7); 2.9604 (0.8); 2.9401 (0.7); 2.6698 (0.7); 2.5232 (4.2); 2.5186 (5.6); 2.5099 (37.4); 2.5053 (77.6); 2.5007 (106.7); 2.4961 (74.8); 2.4915 (33.5); 2.4600 (0.7); 2.4552 (1.0); 2.4506 (1.3); 2.4460 (0.9); 2.3275 (0.7); 1.1756 (0.8); 0.0080 (2.2); 0.0064 (0.8); 0.0056 (0.8); 0.0048 (0.9); 0.0039 (1.1); -0.0002 (65.4); -0.0058 (1.3); -0.0067 (1.1); -0.0085 (2.2); -0.0503 (0.7) I.5-31:1H NMR (400.0MHz, d6-DMSO): δ= 9.1527 (16.0); 8.3945 (4.1); 8.3779 (4.0); 7.6905 (2.7); 7.6739 (2.9); 7.6563 (2.1); 7.6520 (1.6); 7.6485 (1.4); 7.6399 (1.2); 7.6384 (1.3); 7.6326 (1.5); 7.5892 (0.6); 7.5828 (0.6); 7.5798 (0.6); 7.5771 (0.7); 7.5715 (1.6); 7.5660 (1.5); 7.5561 (1.1); 7.5526 (1.2); 7.5478 (1.5); 7.5371 (0.6); 7.5180 (0.5); 7.5018 (11.4); 7.4981 (11.8); 7.4819 (13.8); 7.4781 (13.9); 7.4617 (0.6); 7.4551 (0.7); 7.4495 (0.9); 7.4468 (0.8); 7.4418 (0.8); 7.4376 (1.4); 7.4280 (2.3); 7.4231 (3.0); 7.4195 (2.4); 7.4118 (4.0); 7.4069 (0.7); 7.4042 (1.6); 7.4008 (2.4); 7.3956 (1.4); 7.3820 (0.6); 7.3769 (0.5); 7.3414 (5.5); 7.3376 (5.9); 7.3226 (10.1); 7.3188 (9.6); 7.3030 (7.9); 7.2991 (7.3); 7.2495 (5.7); 7.2455 (5.8); 7.2300 (7.4); 7.2262 (7.4); 7.2111 (3.5); 7.2071 (3.3); 4.8127 (2.1); 4.5910 (0.7); 4.5733 (2.3); 4.5556 (2.4); 4.5434 (1.3); 4.5380 (0.9); 4.5204 (3.4); 4.5002 (6.5); 4.4799 (3.6); 4.4765 (3.7); 4.4563 (1.8); 4.1662 (0.5); 4.1247 (0.6); 4.1070 (0.6); 3.8105 (6.0); 3.7932 (6.6); 3.7850 (7.5); 3.7677 (6.5); 3.3716 (5.7); 3.3614 (5.7); 3.3452 (5.2); 3.3359 (5.5); 3.3222 (407.6); 3.2903 (0.7); 3.2879 (0.8); 3.2724 (3.7); 3.2226 (0.6); 3.1752 (2.1); 3.1622 (2.1); 3.1105 (0.6); 3.0983 (0.7); 3.0809 (0.6); 2.7356 (7.9); 2.7147 (8.8); 2.6933 (10.4); 2.6724 (9.6); 2.5237 (1.4); 2.5190 (2.0); 2.5102 (50.6); 2.5057 (116.5); 2.5010 (166.9); 2.4964 (118.3); 2.4918 (54.0); 2.4560 (1.7); 2.4512 (2.0); 2.4468 (1.6); 2.4062 (0.6); 2.3324 (1.0); 2.3279 (1.3); 2.3232 (1.0); 2.3186 (0.7); 2.2975 (3.2); 2.2870 (3.2); 2.2553 (2.6); 2.2449 (2.7); 2.2166 (1.6); 2.1915 (5.4); 2.1667 (9.5); 2.1634 (7.3); 2.1422 (7.6); 2.1390 (6.4); 2.1176 (2.5); 2.0732 (0.5); 2.0400 (0.6); 2.0272 (2.1); 2.0133 (4.7); 2.0048 (4.5); 2.0010 (6.4); 1.9959 (6.3); 1.9854 (6.2); 1.9805 (6.2); 1.9704 (4.2); 1.9572 (2.0); 1.9539 (2.0); 1.6691 (2.4); 1.6543 (6.5); 1.6417 (7.1); 1.6299 (12.1); 1.6157 (6.1); 1.6053 (5.7); 1.5951 (1.7); 1.5898 (2.1); 1.3404 (2.5); 1.3227 (5.5); 1.3050 (2.5); 1.2506 (0.8); 1.2329 (1.8); 1.2150 (0.8); 1.1942 (2.1); 1.1761 (4.3); 1.1578 (2.2); 1.1538 (3.2); 1.1360 (6.0); 1.1183 (2.7); -0.0002 (3.6) I.5-32:1H NMR (400.0MHz, d6-DMSO): δ= 9.1471 (2.6); 8.3182 (0.6); 7.8979 (2.9); 7.8924 (1.2); 7.8808 (1.9); 7.8750 (9.6); 7.8532 (9.3); 7.8475 (2.0); 7.8361 (1.2); 7.8304 (2.9); 7.4074 (2.1); 7.2666 (1.9); 7.2459 (3.8); 7.2090 (2.6); 7.2034 (2.4); 7.1883 (1.3); 7.1829 (1.3); 4.9908 (0.6); 4.2733 (1.3); 4.2561 (1.6); 4.2472 (1.7); 4.2299 (1.4); 4.0561 (1.0); 4.0383 (3.0); 4.0205 (3.1); 4.0028 (1.0); 3.8198 (1.2); 3.8115 (1.1); 3.7945 (1.0); 3.7859 (1.0); 3.3033 (56.2); 3.0832 (1.4); 3.0624 (1.6); 3.0398 (1.9); 3.0188 (1.6); 2.6737 (1.1); 2.6689 (1.4); 2.6644 (1.0); 2.6182 (1.1); 2.6082 (1.2); 2.5735 (1.0); 2.5639 (1.0); 2.5225 (4.0); 2.5178 (5.7); 2.5091 (81.5); 2.5046 (174.7); 2.5000 (242.2); 2.4954 (169.3); 2.4909 (76.2); 2.3313 (0.9); 2.3267 (1.4); 2.3223 (1.0); 2.1390 (16.0); 1.9875 (14.2); 1.2471 (1.2); 1.1923 (3.6); 1.1745 (7.3); 1.1568 (3.5); 0.8754 (0.6); 0.8584 (1.9); 0.8406 (0.6); 0.0080 (3.0); -0.0002 (96.4); -0.0085 (2.7) I.5-33:1H NMR (400.0 MHz, i.e6-DMSO): δ= 9.1803 (3.6); 8.4015 (1.0); 8.3892 (0.9); 7.7070 (0.8); 7.6865 (0.9); 7.6625 (6.1); 7.6565 (6.3); 7.4150 (4.1); 7.4089 (3.9); 7.3933 (3.5); 7.3872 (3.4); 5.7522 (1.2); 4.7987 (0.6); 4.2024 (0.7); 4.1856 (1.8); 4.1687 (2.6); 4.1517 (1.9); 4.1349 (0.7); 3.6664 (1.7); 3.6491 (1.8); 3.6408 (2.0); 3.6237 (1.8); 3.3053 (46.1); 3.2091 (1.5); 3.1995 (1.5); 3.1835 (1.4); 3.1741 (1.4); 2.7097 (2.2); 2.6888 (2.4); 2.6738 (0.6); 2.6676 (3.2); 2.6468 (2.5); 2.5227 (1.9); 2.5180 (2.7); 2.5094 (42.3); 2.5048 (93.1); 2.5002 (131.3); 2.4955 (92.3); 2.4909 (42.1); 2.4685 (0.6); 2.4637 (0.6); 2.4595 (0.6); 2.4554 (0.6); 2.4508 (0.7); 2.3316 (0.6); 2.3269 (0.8); 2.3224 (0.6); 2.2827 (0.9); 2.2715 (0.9); 2.2396 (0.8); 2.2299 (0.7); 1.0787 (14.4); 1.0655 (15.9); 1.0618 (16.0); 1.0486 (14.4); 0.0080 (2.2); -0.0002 (78.0); -0.0085 (2.5) The subject of the present invention is the use of at least one pyrrolidinone of the general formula (I), in combination with other agrochemical active ingredients such as fungicides, insecticides, herbicides, plant growth regulators or safeners, to increase the resistance of plants to abiotic stress factors, prefers drought stress, as well as to strengthen plant growth and/or to increase plant yield. Another subject of the present invention is a spray solution for treating plants, containing an amount of at least one compound selected from the group consisting of at least one of the substituted pyrrolidinones according to the invention, of the general formula (I ). The abiotic stress conditions that can be put into perspective include, for example, heat, drought, cold and drought stress (stress caused by drought and/or lack of water), osmotic stress, waterlogging, increased soil salinity, increased exposure to minerals, ozone conditions, strong light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients. In one embodiment, it can be provided, for example, that one or more of the compounds to be used according to the invention, i. H. the corresponding pyrrolidinones of the general formula (I) substituted according to the invention can be applied by spray application to plants or parts of plants to be treated accordingly. The compounds of the general formula (I) or their salts are preferably used at a dosage of between 0.00005 and 3 kg/ha, particularly preferably between 0.0001 and 2 kg/ha, particularly preferably between 0.0005 and 1 kg/ha. ha, especially preferably between 0.001 and 0.25 kg/ha. In the context of the present invention, the term resistance or resilience to abiotic stress is understood to mean various advantages for plants. Such advantageous properties are expressed, for example, in the improved plant characteristics mentioned below: improved root growth in terms of surface and depth, increased stolon formation or tillering, stronger and more productive stolons and tillers, improvement in shoot growth, increased stability, increased shoot base diameter, increased leaf area, higher yields of nutrients and ingredients such as carbohydrates, fats, oils, proteins, vitamins, minerals, essential oils, dyes, fibres, better fiber quality, earlier flowering, increased number of flowers, reduced levels of toxic products such as mycotoxins, reduced levels of residues or unfavorable components of any kind or better digestibility, improved storage stability of the crop, improved tolerance to unfavorable temperatures, improved tolerance to drought and drought, as well as water starvation excess, improved tolerance to increased salt levels in soil and water, increased tolerance to ozone stress, improved tolerance to herbicides and other plant treatment products, improved water absorption and photosynthetic performance, advantageous plant properties, such as accelerated ripening, more even ripening, greater attraction for beneficial organisms, improved pollination or other advantages well known to those skilled in the art. In particular, the use of one or more compounds of the general formula (I) according to the invention in spray application to plants and parts of plants shows the advantages described. The combined use of N-sulfonyl-N'-aryldiaminoalkanes according to the invention and N-sulfonyl-N'-heteroaryldiaminoalkanes of the general formula (I) with genetically modified varieties with regard to increased abiotic stress tolerance is also possible. As is well known, the various advantages for plants mentioned above can be partially summarized and documented with generally applicable terms. Such terms are, for example, the terms listed below: phytotonic effect, resistance to stress factors, less plant stress, plant health, healthy plants, plant fitness (“Plant Fitness”), “Plant Wellness”, “Plant Concept”, “Vigor Effect”, “Stress Shield, Crop Health, Crop Health Properties, Crop Health Products, Crop Health Management, Crop Health Therapy, Plant Health, Plant Health Properties, Plant Health Products, Plant Health Management", "Plant Health Therapy", "Greening Effect" or "Re-greening Effect"), "Freshness" or other terms well known to a person skilled in the art. In the present invention, a good effect on abiotic stress resistance is not limited • at least one emergence improved by generally 3%, in particular greater than 5%, particularly preferably greater than 10%, • at least one yield increased by generally 3%, in particular greater than 5%, particularly preferably greater than 10%, • at least one by im Generally 3%, in particular greater than 5%, particularly preferably greater than 10% improved root development, • at least one shoot size increasing by generally 3%, in particular greater than 5%, particularly preferably greater than 10%, • at least one by generally 3%, in particular greater than 5%, particularly preferably greater than 10%, • at least one photosynthesis performance improved by generally 3%, in particular greater than 5%, particularly preferably greater than 10% and/or • at least one by generally 3%, in particular greater understood as 5% particularly preferably greater than 10% improved flower formation, the effects being individual or in any combination ion of two or more effects can occur. The present invention further provides a spray solution for treating plants, containing an amount of at least one compound from the group of substituted pyrrolidinones of the general formula (I) effective to increase the resistance of plants to abiotic stress factors. The spray solution can contain other customary components, such as solvents, formulation auxiliaries, in particular water. Other components can be, inter alia, agrochemical active ingredients, which are described in more detail below. Another object of the present invention is the use of corresponding spray solutions to increase the resistance of plants to abiotic stress factors. The statements below apply both to the use of one or more compounds of the general formula (I) according to the invention per se and to the corresponding spray solutions. In addition, it has been found that the application of one or more compounds of the general formula (I) according to the invention in combination with at least one fertilizer as defined below is possible on plants or in their environment. Fertilizers which can be used according to the invention together with the compounds of the general formula (I) according to the invention explained in more detail above are generally organic and inorganic nitrogen-containing compounds such as ureas, urea-formaldehyde condensation products, amino acids, ammonium salts and nitrates, potassium salts (preferably chlorides, sulfates, nitrates), phosphoric acid salts and/or salts of phosphorous acid (preferably potassium salts and ammonium salts). Particularly noteworthy in this context are the NPK fertilizers, i.e. fertilizers that contain nitrogen, phosphorus and potassium, calcium ammonium nitrate, i.e. fertilizers that also contain calcium, ammonium sulphate nitrate (general formula (NH4)2SO4 NH4NO3), ammonium phosphate and ammonium sulphate. These fertilizers are well known to those skilled in the art, see also, for example, Ullmann's Encyclopedia of Industrial Chemistry, 5th Edition, Vol. A 10, pages 323 to 431, Verlagsgesellschaft, Weinheim, 1987. The fertilizers can also contain salts from micronutrients (preferably calcium, boron, manganese, magnesium, iron, boron, copper, zinc, molybdenum and cobalt) and phytohormones (e.g. vitamin B1 and indole(III)acetic acid) or mixtures thereof. Fertilizers used according to the invention can also contain other salts such as monoammonium phosphate (MAP), diammonium phosphate (DAP), potassium sulfate, potassium chloride, magnesium sulfate. Suitable amounts for the secondary nutrients or trace elements are amounts of 0.5 to 5% by weight, based on the fertilizer as a whole. Other possible ingredients are crop protection agents, insecticides, fungicides, safeners or growth regulators or mixtures thereof. Further explanations on this follow below. The fertilizers can be used, for example, in the form of powders, granules, prills or compacts. However, the fertilizers can also be used in liquid form, dissolved in an aqueous medium. In this case, diluted aqueous ammonia can also be used as a nitrogen fertilizer. Further possible ingredients for fertilizers are described, for example, in Ullmann's Encyclopedia of Industrial Chemistry, 5th edition, 1987, volume A 10, pages 363 to 401, DE-A 4128828, DE-A 1905834 and DE-A 19631764. The general composition of the fertilisers, which in the context of the present invention can be straight and/or complex fertilizers, for example nitrogen, potassium or phosphorus, can vary within a wide range. In general, a content of 1 to 30% by weight nitrogen (preferably 5 to 20% by weight), 1 to 20% by weight potassium (preferably 3 to 15% by weight) and a content of 1 to 20% by weight phosphorus (preferably 3 to 10% by weight) is advantageous. The content of microelements is usually in the ppm range, preferably in the range from 1 to 1000 ppm. Within the scope of the present invention, the fertilizer and one or more compounds of the general formula (I) according to the invention can be administered simultaneously. However, it is also possible first to use the fertilizer and then to use one or more compounds of the general formula (I) according to the invention, or first to use one or more compounds of the general formula (I) and then to use the fertilizer. If one or more compounds of the general formula (I) and the fertilizer are not used at the same time, the application in the context of the present invention takes place in a functional context, in particular within a period of generally 24 hours, preferably 18 hours, particularly preferably 12 hours, specifically 6 hours, even more special 4 hours, even more special within 2 hours. In very particular embodiments of the present invention, one or more compounds of the formula (I) according to the invention and the fertilizer are applied within a time frame of less than 1 hour, preferably less than 30 minutes, particularly preferably less than 15 minutes. Preference is given to using compounds of the general formula (I) according to the invention on plants from the group consisting of useful plants, ornamental plants, lawn species, trees in general use which are used as ornamental plants in public and private areas, and forest stock. Forest stock includes trees for the manufacture of wood, pulp, paper and products made from parts of the trees. The term useful plants, as used here, refers to crop plants that are used as plants for the production of food, animal feed, fuel or for technical purposes. The useful plants include B. the following plant species: triticale, durum (hard wheat), turf, vines, cereals, for example wheat, barley, rye, oats, rice, maize and millet; Beet, for example sugar beet and fodder beet; Fruits, for example pome fruit, stone fruit and berries, for example apples, pears, plums, peaches, almonds, cherries and berries, e.g. B. strawberries, raspberries, blackberries; legumes such as beans, lentils, peas and soybeans; Oil crops, for example rapeseed, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans and peanuts; cucumber plants such as squash, cucumbers and melons; fiber crops such as cotton, flax, hemp and jute; citrus fruits, e.g. oranges, lemons, grapefruits and tangerines; vegetables, for example spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes and peppers; Laurel plants, for example avocado, cinnamomum, camphor, or plants such as tobacco, nuts, coffee, eggplant, sugar cane, tea, pepper, grapevines, hops, bananas, natural rubber plants and ornamental plants, for example flowers, shrubs, deciduous trees and conifers such as conifers. This list does not represent a limitation. The following plants are to be regarded as particularly suitable target crops for the application of the method according to the invention: oats, rye, triticale, durum, cotton, eggplant, turf, pome fruit, stone fruit, soft fruit, corn, wheat, barley, cucumber, tobacco, vines, rice, cereals , pear, pepper, beans, soybeans, canola, tomato, pepper, melon, cabbage, potato and apple. As trees which can be improved according to the method of the present invention, there can be exemplified: Abies sp., Eucalyptus sp., Picea sp., Pinus sp., Aesculus sp., Platanus sp., Tilia sp., Acer sp., Tsuga sp ., Fraxinus sp., Sorbus sp., Betula sp., Crataegus sp., Ulmus sp., Quercus sp., Fagus sp., Salix sp., Populus sp.. As preferred trees that can be improved according to the method of the present invention , can be named: From the tree species Aesculus: A. hippocastanum, A. pariflora, A. carnea; from the tree species Platanus: P. aceriflora, P. occidentalis, P. racemosa; from the tree species Picea: P. abies; from the tree species Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. elliottii, P. montecola, P. albicaulis, P. resinosa, P. palustris, P. taeda, P. flexilis, P .jeffregi, P. baksiana, P. strobes; from the tree species Eucalyptus: E. grandis, E. globulus, E. camadentis, E. nitens, E. obliqua, E. regnans, E. pilularus. Particularly preferred trees which can be improved according to the method according to the invention can be mentioned: From the tree species Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. strobes; from the tree species Eucalyptus: E. grandis, E. globulus and E. camadentis. As particularly preferred trees which can be improved according to the method of the present invention, there can be mentioned: horse chestnut, sycamore, linden and maple tree. The present invention can also be practiced on any turfgrasses, including cool season turfgrasses and warm season turfgrasses. Examples of lawn types for the cold season are blue grasses (Poa spp.), such as Kentucky bluegrass (Poa pratensis L.), rough bluegrass (Poa trivialis L.), Canada bluegrass (Poa compressa L.), annual bluegrass (Poa annua L.), upland bluegrass (Poa glaucantha Gaudin), wood bluegrass (Poa nemoralis L.) and bulbous bluegrass (Poa bulbosa L.); Bentgrass (Agrostis spp.), such as creeping bentgrass (Agrostis palustris Huds.), colonial bentgrass (Agrostis tenuis Sibth.), velvet bentgrass (Agrostis canina L.), South German Mixed Bentgrass ' (Agrostis spp. including Agrostis tenius Sibth., Agrostis canina L., and Agrostis palustris Huds.), and 'redtop' (Agrostis alba L.); Fescues ("Fescues", Festucu spp.), such as "red fescue" (Festuca rubra L. spp. rubra), "creeping fescue" (Festuca rubra L.), "chewings fescue" (Festuca rubra commutata Gaud.), " sheep fescue” (Festuca ovina L.), hard fescue (Festuca longifolia Thuill.), hair fescue (Festucu capillata Lam.), tall fescue (Festuca arundinacea Schreb.) and meadow fescue (Festuca elanor L.); Lolch ('ryegrasses', Lolium spp.) such as annual ryegrass (Lolium multiflorum Lam.), perennial ryegrass (Lolium perenne L.) and Italian ryegrass (Lolium multiflorum Lam.); and wheatgrasses (Agropyron spp..) such as fairway wheatgrass (Agropyron cristatum (L.) Gaertn.), crested wheatgrass (Agropyron desertorum (Fisch.) Schult.) and western wheatgrass (Agropyron smithii Rydb.). Examples of other “cool season turfgrasses” are “beachgrass” (Ammophila breviligulata Fern.), “smooth bromegrass” (Bromus inermis Leyss.), “cattails” like “Timothy” (Phleum pratense L.), “sand cattail (Phleum subulatum L.), orchardgrass (Dactylis glomerata L.), weeping alkaligrass (Puccinellia distans (L.) Parl.) and crested dog's-tail (Cynosurus cristatus L.). Examples of warm season turfgrasses are Bermudagrass (Cynodon spp. L.C. Rich), Zoysiagrass (Zoysia spp. Willd.), St. Augustine grass (Stenotaphrum secundatum Walt Kuntze), centipedegrass (Eremochloa ophiuroides Munro Hack.), carpetgrass (Axonopus affinis Chase), Bahia grass (Paspalum notatum Flugge), Kikuyugrass (Pennisetum clandestinum Hochst. ex Chiov .), buffalo grass (Buchloe dactyloids (Nutt.) Engelm.), blue gramma (Bouteloua gracilis (H.B.K.) Lag. ex Griffiths), seashore paspalum (Paspalum vaginatum Swartz) and sideoats grama (Bouteloua curtipendula (Michx. Torr.). "Cool season turfgrasses" are generally preferred for use according to the invention. Blue grass, bent grass and "redtop", fescue and ryefoot are particularly preferred. Bent grass is particularly preferred. Particularly preferred with the compounds according to the invention are the general formula (I) plants of the plant cultivars that are commercially available or in use Plant cultivars are plants with new properties (“traits”) that have by mutagenesis or by recombinant DNA techniques. Accordingly, crop plants can be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including transgenic plants and including plant varieties which can or cannot be protected by plant variety rights. The treatment method according to the invention can thus also be used for the treatment of genetically modified organisms (GMOs), e.g. As plants or seeds can be used. Genetically modified plants (or transgenic plants) are plants in which a heterologous gene is stable in the genome has been integrated. The term "heterologous gene" essentially means a gene that is provided or assembled outside of the plant and, when introduced into the nuclear genome, chloroplast genome, or hypochondriacal genome, confers new or improved agronomic or other traits on the transformed plant by producing a trait of interest protein or polypeptide, or that it downregulates or shuts down another gene(s) present in the plant (e.g., using antisense technology, co-suppression technology, or RNA interference [RNAi] technology) . A heterologous gene that is present in the genome is also called a transgene. A transgene that is defined by its specific presence in the plant genome is referred to as a transformation or transgenic event. Plants and plant varieties that are preferably treated with the compounds of the general formula (I) according to the invention include all plants that have genetic material that gives these plants particularly advantageous, useful traits (regardless of whether this is achieved by breeding and/or biotechnology would). Plants and plant cultivars which can also be treated with the compounds of the general formula (I) according to the invention are those plants which are resistant to one or more abiotic stress factors. Abiotic stress conditions can include, for example, heat, drought, cold and drought stress, osmotic stress, waterlogging, increased soil salinity, increased exposure to minerals, ozone conditions, high light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients, or avoidance of shade. Plants and plant cultivars which can also be treated with the compounds of the general formula (I) according to the invention are those plants which are characterized by increased yield-related properties. An increased yield can be achieved with these plants e.g. B. based on improved plant physiology, improved plant growth and improved plant development, such as water use efficiency, water holding efficiency, improved nitrogen utilization, increased carbon assimilation, improved photosynthesis, enhanced germination and accelerated ripening. Yield can be further influenced by improved plant architecture (under stressed and non-stressed conditions) including early flowering, control of flowering for hybrid seed production, seedling vigour, plant size, internodal number and spacing, root growth, seed size, fruit size, Pod size, number of pods or spikes, number of seeds per pod or spike, seed mass, increased seed filling, reduced seed loss, reduced pod bursting and stability. Other yield traits include seed composition such as carbohydrate content, protein content, oil content and oil composition, Nutritional value, reduction of anti-nutritional compounds, improved processability and improved shelf life. Plants which can also be treated with the compounds of the general formula (I) according to the invention are hybrid plants which already express the properties of heterosis or the hybrid effect, which generally leads to higher yield, higher vigor, better health and better resistance to biotic and abiotic stressors. Such plants are typically produced by crossing an inbred male-sterile parent line (the female parent) with another inbred male-fertile parent line (the male parent). The hybrid seed is typically harvested from the male-sterile plants and sold to propagators. Male-sterile plants can sometimes (e.g., in maize) be produced by detasseling (i.e., mechanically removing the male reproductive organs or male flowers); however, it is more common that male sterility is due to genetic determinants in the plant genome. In this case, particularly when the desired product to be harvested from the hybrid plants is the seed, it is usually desirable to ensure male fertility in hybrid plants containing the genetic determinants responsible for male sterility , will be completely restored. This can be accomplished by ensuring that the male parents possess appropriate fertility restorer genes capable of restoring male fertility in hybrid plants containing the genetic determinants responsible for male sterility. Genetic determinants of male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) have been described for example for Brassica species (WO92/005251, WO95/009910, WO98/27806, WO2005/002324, WO2006/021972 and US6,229,072). However, genetic determinants of male sterility can also be located in the nuclear genome. Male-sterile plants can also be obtained using plant biotechnology methods such as genetic engineering. A particularly useful means of producing male-sterile plants is described in WO 89/10396, where for example a ribonuclease such as a barnase is selectively expressed in the tapetum cells in the stamens. Fertility can then be restored by expression of a ribonuclease inhibitor such as Barstar in the tapetum cells (e.g. WO91/002069). Plants or plant cultivars (obtained using methods of plant biotechnology, such as genetic engineering) which can also be treated with the compounds of general formula (I) according to the invention are herbicide-tolerant plants, i. H. Plants that have been made tolerant to one or more specified herbicides. Such plants can be obtained either by genetic transformation or by selection from plants containing a mutation conferring such herbicide tolerance. Herbicide-tolerant plants are, for example, glyphosate-tolerant plants, i. H. Plants that have been made tolerant to the herbicide glyphosate or its salts. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., Science (1983), 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp. (Barry et al., Curr. Topics Plant Physiol. (1992), 7, 139-145), the genes coding for an EPSPS from petunia (Shah et al., Science (1986), 233, 478-481) , for an EPSPS from tomato (Gasser et al., J. Biol. Chem. (1988), 263, 4280-4289) or for an EPSPS from Eleusins (WO2001/66704). It can also be a mutated EPSPS, as described for example in EP-A 0837944, WO2000/066746, WO2000/066747 or WO2002/026995. Glyphosate tolerant plants can also be obtained by expressing a gene encoding a glyphosate oxidoreductase enzyme as described in US5,776,760 and US5,463,175. Glyphosate tolerant plants can also be obtained by expressing a gene encoding a glyphosate acetyltransferase enzyme as described in e.g. B. WO2002/036782, WO2003/092360, WO2005/012515 and WO2007/024782. Glyphosate tolerant plants can also be obtained by selecting plants containing naturally occurring mutations of the genes mentioned above, as described for example in WO01/024615 or WO2003/013226. Other herbicide-resistant plants are, for example, plants which have been made tolerant to herbicides which inhibit the enzyme glutamine synthase, such as bialaphos, phosphinotricin or glufosinate. Such plants can be obtained by expressing an enzyme that detoxifies the herbicide or a mutant of the enzyme glutamine synthase that is resistant to inhibition. Such a potent detoxifying enzyme is, for example, an enzyme encoding a phosphinotricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinotricin acetyltransferase are described, for example, in US5,561,236; US5,648,477; US5,646,024; US5,273,894; US5,637,489; US5,276,268; US5,739,082; US5,908,810 and US7,112,665. Other herbicide-tolerant plants are also plants that have been made tolerant to the herbicides that inhibit the enzyme hydroxyphenylpyruvate dioxygenase (HPPD). The hydroxyphenylpyruvate dioxygenases are enzymes that catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is converted into homogentisate. Plants that are tolerant to HPPD inhibitors can be endowed with a gene encoding a naturally occurring resistant HPPD enzyme or a gene encoding a mutant HPPD enzyme according to WO96/038567, WO99/024585 and WO99/024586 , to be transformed. Tolerance to HPPD inhibitors can also be achieved by transforming plants with genes encoding encode certain enzymes that allow the formation of homogentisate despite inhibition of the native HPPD enzyme by the HPPD inhibitor. Such plants and genes are described in WO99/034008 and WO2002/36787. The tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding a prephenate dehydrogenase enzyme in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO2004/024928 is described. Other herbicide resistant plants are plants that have been made tolerant to acetolactate synthase (ALS) inhibitors. Known ALS inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidines, pyrimidinyloxy(thio)benzoates and/or sulfonylaminocarbonyltriazolinone herbicides. It is known that different mutations in the enzyme ALS (also known as acetohydroxy acid synthase, AHAS) confer tolerance to different herbicides or groups of herbicides, as for example in Tranel and Wright, Weed Science (2002), 50, 700-712, but also in US5,605,011, US5,378,824, US5,141,870 and US5,013,659. The production of sulfonylurea tolerant plants and imidazolinone tolerant plants is described in US5,605,011; US5,013,659; US5,141,870; US5,767,361; US5,731,180; US5,304,732; US4,761,373; US5,331,107; US5,928,937; and US5,378,824; and in International Publication WO96/033270. Other imidazolinone-tolerant plants are also found in e.g. B. WO2004/040012, WO2004/106529, WO2005/020673, WO2005/093093, WO2006/007373, WO2006/015376, WO2006/024351 and WO2006/060634 are described. Other sulfonylurea- and imidazolinone-tolerant plants are also described, for example, in WO2007/024782. Other plants that are tolerant to ALS inhibitors, in particular to imidazolinones, sulfonylureas and/or sulfamoylcarbonyltriazolinones, can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or by mutation breeding, as is the case, for example, for the soybean in US5,084,082 , for rice in WO97/41218, for sugar beet in US5,773,702 and WO99/057965, for lettuce in US5,198,599 or for sunflower in WO2001/065922. Plants or plant varieties (obtained by methods of plant biotechnology, such as genetic engineering) which can also be treated with the compounds of general formula (I) according to the invention are insect-resistant transgenic plants, i.e. plants which are resistant to infestation by certain target insects were made. Such plants can be obtained by genetic transformation or by selection from plants containing a mutation conferring such insect resistance. The term "insect resistant transgenic plant" as used herein includes any plant containing at least one transgene comprising a coding sequence encoding: 1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal part thereof, such as the insecticidal crystal proteins that by Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, by Crickmore et al. (2005) in the Bacillus thuringiensis toxin nomenclature (online at: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal parts thereof, e.g. proteins of the Cry protein classes Cry1Ab, Cry1Ac , Cry1F, Cry2Ab, Cry3Ae or Cry3Bb or insecticidal parts thereof; or 2) a crystal protein from Bacillus thuringiensis or part thereof which is insecticidal in the presence of a second, different crystal protein than Bacillus thuringiensis or part thereof, such as the binary toxin consisting of the crystal proteins Cy34 and Cy35 (Moellenbeck et al., Nat Biotechnol (2001) 19 668-72 Schnepf et al Applied Environment Microb (2006) 71 1765-1774); or 3) an insecticidal hybrid protein comprising parts of two different insecticidal crystal proteins from Bacillus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, e.g. B. the protein Cry1A.105 produced by the maize event MON98034 (WO2007/027777); or 4) a protein according to any one of points 1) to 3) above, in which some, in particular 1 to 10, amino acids have been replaced by another amino acid in order to achieve higher insecticidal activity against a target insect species and / or to the spectrum of to expand corresponding target insect species and/or due to changes induced in the coding DNA during cloning or transformation, such as the protein Cry3Bb1 in maize events MON863 or MON88017 or the protein Cry3A in maize event MIR 604; or 5) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus or an insecticidal part thereof, such as the vegetative insecticidal proteins (VIP) listed at the following link, e.g. B. Proteins of the VIP3Aa protein class: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/vip.html or 6) a secreted protein from Bacillus thuringiensis or Bacillus cereus, in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin consisting of the proteins VIP1A and VIP2A (WO94/21795); or 7) an insecticidal hybrid protein comprising parts of different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins of 1) or a hybrid of the proteins of 2) above; or 8) a protein according to any one of points 1) to 3) above, in which some, in particular 1 to 10, amino acids have been replaced by another amino acid in order to achieve higher insecticidal activity against a target insect species and / or to the spectrum of corresponding target insect species and/or because of changes induced in the coding DNA during cloning or transformation (while preserving the coding for an insecticidal protein), such as the protein VIP3Aa in the cotton event COT 102. Of course, one of the insect-resistant transgenic plants in the present context also includes any plant comprising a combination of genes encoding the proteins of any of classes 1 to 8 above. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein according to any one of the above 1 to 8 in order to broaden the spectrum of the corresponding target insect species or to delay the development of resistance of the insects to the plants by employs different proteins that are insecticidal to the same target insect species but have a different mode of action, such as binding to different receptor-binding sites in the insect. Plants or plant cultivars (obtained by methods of plant biotechnology, such as genetic engineering) which can also be treated with the compounds of general formula (I) according to the invention are tolerant to abiotic stress factors. Such plants can be obtained by genetic transformation or by selection from plants containing a mutation conferring such stress resistance. Particularly useful stress tolerant plants include the following: a. Plants containing a transgene capable of reducing the expression and/or activity of the gene for poly(ADP-ribose) polymerase (PARP) in the plant cells or plants, as described in WO2000/004173 or EP04077984.5 or EP06009836. 5 is described. b. Plants which contain a stress tolerance-promoting transgene which is able to reduce the expression and/or activity of the PARG-encoding genes of the plants or plant cells, as described, for example, in WO2004/090140; c. Plants containing a stress tolerance promoting transgene encoding a plant functional enzyme of the nicotinamide adenine dinucleotide salvage biosynthetic pathway, including Nicotinamidase, nicotinate phosphoribosyl transferase, nicotinic acid mononucleotide adenyl transferase, nicotinamide adenine dinucleotide synthetase or nicotinamide phosphoribosyl transferase, as z. in EP04077624.7 or WO2006/133827 or PCT/EP07/002433. Plants or plant varieties (obtained by methods of plant biotechnology, such as genetic engineering), which can also be treated with the compounds of the general formula (I) according to the invention, have a changed quantity, quality and / or shelf life of the harvested product and / or altered properties of certain components of the harvested product, such as: 1) Transgenic plants that synthesize a modified starch that differ in terms of their chemical-physical properties, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the average chain length, the distribution of the side chains, the viscosity behavior, the gel strength, the starch granule size and/or starch granule morphology compared to the synthesized starch in wild-type plant cells or plants, so that this modified starch is better suited for certain applications. These transgenic plants synthesizing a modified starch are for example in EP0571427, WO95/004826, EP0719338, WO96/15248, WO96/19581, WO96/27674, WO97/11188, WO 97/26362, WO97/32985, WO97/42328 , WO97/44472, WO97/45545, WO98/27212, WO98/40503, WO99/58688, WO99/58690, WO99/58654, WO2000/008184, WO2000/008185, WO2000/28052, WO2000/77229, WO20001/2 /12826, WO2002/1059, WO2003/071860, WO2004/056999, WO2005/030941, WO2005/095632 , WO2006/108702, WO2007/009823, WO2000/22140, WO2006/072603, WO2002/034923, EP06090228.5, EP06090227.7, WO2001, ep07090009.7 /79410, WO2003/33540, WO2004/078983, WO2001/19975, WO95/26407, WO96/34968, WO98/20145, WO99/12950, WO99/66050, WO99/53072, US6,734,341, WO2000/11482260 , WO98/32326, WO2001/98509, WO2001/98509, WO2005/002359, US5,824,790, US6,013,861, WO94/004693, WO 94/009144, WO94/11520, WO95/35026 and WO97/20936, respectively. 2) Transgenic plants that synthesize non-starch carbohydrate polymers, or non-starch carbohydrate polymers whose properties are altered compared to wild-type plants without genetic modification. Examples are plants producing polyfructose, particularly of the inulin and levan types as described in EP0663956, WO96/001904, WO96/021023, WO98/039460 and WO99/024593, plants producing alpha-1,4-glucans , as described in WO95/031553, US2002/031826, US6,284,479, US5,712,107, WO97/047806, WO97/047807, WO97/047808 and WO2000/14249, plants producing alpha-1,6-branched alpha-1,4-glucans as described in WO2000/73422 and plants producing alternan as described in WO2000/ 047727, EP06077301.7, US5,908,975 and EP0728213. 3) Transgenic plants that produce hyaluronan, as described for example in WO06/032538, WO2007/039314, WO2007/039315, WO2007/039316, JP2006/304779 and WO2005/012529. Plants or plant varieties (obtained by methods of plant biotechnology, such as genetic engineering) which can also be treated with the compounds of the general formula (I) according to the invention are plants such as cotton plants with altered fiber properties. Such plants can be obtained by genetic transformation or by selection from plants containing a mutation conferring such altered fiber properties; these include: a) plants such as cotton plants containing an altered form of cellulose synthase genes as described in WO98/000549, b) plants such as cotton plants containing an altered form of rsw2 or rsw3 homologous nucleic acids as described in WO2004 /053219; c) plants such as cotton plants with increased expression of sucrose phosphate synthase, as described in WO2001/017333; d) plants such as cotton plants with increased expression of sucrose synthase, as described in WO2002/45485; e) Plants such as cotton plants in which the timing of gating of the plasmodesmata at the base of the fiber cell is altered, e.g. B. by down-regulating fiber-selective β-1,3-glucanase, as described in WO2005/017157; f) plants such as cotton plants with fibers with altered reactivity, e.g. B. by expression of the N-acetylglucosamine transferase gene, including nodC, and of chitin synthase genes, as described in WO2006/136351. Plants or plant varieties (obtained by methods of plant biotechnology, such as genetic engineering) which are also treated with the compounds of the general formula (I) according to the invention can be treated are crops such as oilseed rape or related Brassica crops with altered oil composition properties. Such plants can be obtained by genetic transformation or by selection from plants containing a mutation conferring such altered oil properties; these include: a) plants such as rape plants which produce oil with a high oleic acid content, as described for example in US5,969,169, US5,840,946 or US6,323,392 or US6,063,947; b) Plants such as rape plants which produce oil with a low linolenic acid content as described in US6,270828, US6,169,190 or US5,965,755. c) Plants, such as rapeseed, which produce oil with a low saturated fatty acid content, e.g. as described in US5,434,283. Particularly useful transgenic plants which can be treated with the compounds of general formula (I) according to the invention are plants which contain transformation events, or a combination of transformation events, and which are, for example, in the files of various national or regional authorities are listed. Particularly useful transgenic plants which can be treated with the compounds of general formula (I) according to the invention are exemplified by plants having one or more genes which code for one or more toxins are the transgenic plants which are offered under the following trade names: YIELD GARD ^ (e.g. corn, cotton, soybeans), KnockOut ^ (e.g. corn), BiteGard ^ (e.g. corn), BT-Xtra ^ (e.g. corn), StarLink ^ (e.g. corn), Bollgard ^ ( Cotton), Nucotn ^ (cotton), Nucotn 33B ^ (cotton), NatureGard ^ (e.g. corn), Protecta ^ and NewLeaf ^ (potato). Herbicide tolerant crops to mention are, for example, corn varieties, cotton varieties and soybean varieties sold under the following trade names: Roundup Ready ^ (glyphosate tolerance, e.g. corn, cotton, soybean), Liberty Link ^ (phosphinotricin tolerance, e.g. canola) , IMI ^ (imidazolinone tolerance) and SCS ^ (sylphonylurea tolerance), for example corn. Among the herbicide-resistant plants (plants traditionally bred for herbicide tolerance) to be mentioned are the varieties sold under the Clearfield ^ designation (for example corn). The compounds of the formula (I) to be used according to the invention can be converted into customary formulations, such as solutions, emulsions, wettable powders, water-based and oil-based suspensions, Powders, dusts, pastes, soluble powders, soluble granules, scattered granules, suspension emulsion concentrates, natural substances impregnated with active substances, synthetic substances impregnated with active substances, fertilizers and very fine encapsulations in polymeric substances. In the context of the present invention, it is particularly preferred if the compounds of the general formula (I) are used in the form of a spray formulation. The present invention therefore also relates to a spray formulation for increasing the resistance of plants to abiotic stress. A spray formulation is described in more detail below: The formulations for spray application are prepared in a known manner, e.g. by mixing the compounds of the general formula (I) to be used according to the invention with extenders, i.e. liquid solvents and/or solid carriers, if appropriate using surface-active agents, ie emulsifiers and/or dispersants and/or foam-forming agents. Other customary additives, such as customary extenders and solvents or diluents, dyes, wetting agents, dispersants, emulsifiers, defoamers, preservatives, secondary thickeners, adhesives, gibberellins and also water, can optionally also be used. The formulations are produced either in suitable systems or else before or during use. Substances that are suitable for imparting special properties to the agent itself or and/or preparations derived from it (e.g. spray mixtures), such as certain technical properties and/or also special biological properties, can be used as auxiliaries. Typical auxiliaries that can be used are: extenders, solvents and carriers. Suitable extenders are, for example, water, polar and non-polar organic chemical liquids, e.g. from the classes of aromatic and non-aromatic hydrocarbons (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), alcohols and polyols (which may also be substituted, etherified and/or may be esterified), ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly)ethers, simple and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, sulfones and sulfoxides (such as dimethyl sulfoxide). If water is used as an extender, for example, organic solvents can also be used as auxiliary solvents. The following are essentially the liquid solvents that can be used: aromatics such as xylene, toluene or alkyl naphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylene or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, e.g. petroleum fractions, mineral and vegetable oils , Alcohols such as butanol or glycol and their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethyl sulfoxide, and water. Dyes such as inorganic pigments, e.g., iron oxide, titanium oxide, ferrocyanide, and organic dyes such as alizarin, azo and metal phthalocyanine dyes, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc can be used. Suitable wetting agents which can be present in the formulations which can be used according to the invention are all substances which promote wetting and which are customary for the formulation of agrochemical active ingredients. Alkyl naphthalene sulfonates such as diisopropyl or diisobutyl naphthalene sulfonates can preferably be used. Suitable dispersants and/or emulsifiers which can be present in the formulations which can be used according to the invention are all nonionic, anionic and cationic dispersants customary for the formulation of agrochemically active compounds. Nonionic or anionic dispersants or mixtures of nonionic or anionic dispersants can preferably be used. Particularly suitable nonionic dispersants are ethylene oxide-propylene oxide block polymers, alkylphenol polyglycol ethers and tristryrylphenol polyglycol ethers and their phosphated or sulfated derivatives. Suitable anionic dispersants are, in particular, lignin sulfonates, polyacrylic acid salts and aryl sulfonate-formaldehyde condensates. All foam-inhibiting substances customary for the formulation of agrochemically active compounds can be present as antifoams in the formulations which can be used according to the invention. Silicone defoamers and magnesium stearate can preferably be used. All substances that can be used for such purposes in agrochemical agents can be present as preservatives in the formulations that can be used according to the invention. Examples which may be mentioned are dichlorophene and benzyl alcohol hemiformal. Secondary thickeners which can be present in the formulations which can be used according to the invention are all substances which can be used for such purposes in agrochemical compositions. Cellulose derivatives, acrylic acid derivatives, xanthan, modified clays and highly disperse silicic acid are preferred. Suitable adhesives which can be present in the formulations which can be used according to the invention are all the customary binders which can be used in mordants. preferably mentioned polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tylose. The gibberellins A1, A3 (=gibberellic acid), A4 and A7 are preferably suitable as gibberellins which can be present in the formulations which can be used according to the invention, with gibberellic acid being particularly preferably used. The gibberellins are known (cf. R. Wegler "Chemistry of plant protection and pest control agents", Vol. 2, Springer Verlag, 1970, pp. 401-412). Other additives can be fragrances, mineral or vegetable oils, optionally modified, waxes and nutrients (also trace nutrients), such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc. Stabilizers such as cold stabilizers, antioxidants, light stabilizers or other agents that improve chemical and/or physical stability can also be present. The formulations generally contain between 0.01 and 98% by weight, preferably between 0.5 and 90% by weight. %, of the compound of general formula (I). The compounds of the general formula (I) according to the invention can be used in commercial formulations and in the use forms prepared from these formulations as a mixture with other active ingredients such as insecticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides, growth-regulating substances, herbicides, safeners, fertilizers or Semiochemicals present. Furthermore, the described positive effect of the compounds of the formula (I) on the plants' own defenses can be supported by additional treatment with insecticidal, fungicidal or bactericidal active ingredients. Preferred times for the application of the compounds of the general formula (I) according to the invention or their salts to increase the resistance to abiotic stress are soil, stem and/or leaf treatments with the permitted application rates. The compounds of the general formula (I) according to the invention or their salts can generally also be used in their commercial formulations and in the use forms prepared from these formulations in mixtures with other active ingredients such as insecticides, attractants, sterilants, acaricides, nematicides, fungicides, bactericides, growth-regulating substances, substances that affect plant maturity, safeners or herbicides. The active ingredients of the general formula (I) can generally also in their commercial formulations and in the use forms prepared from these formulations in mixtures with other active ingredients such as insecticides, attractants, sterilants, acaricides, nematicides, fungicides, bactericides, growth-regulating substances that Plant maturity influencing substances, safeners or herbicides are present. Particularly favorable mixing partners are, for example, the active ingredients of the various classes listed below in groups, without any preference being set based on their order: F1) Inhibitors of nucleic acid synthesis, eg. B. benalaxyl, benalaxyl-M, bupirimate, chiralaxyl, clozylacone, dimethirimol, ethirimol, furalaxyl, hymexazole, metalaxyl, metalaxyl-M, ofurace, oxadixyl, oxolinic acid; F2) Inhibitors of mitosis and cell division, e.g. B. benomyl, carbendazim, diethofencarb, fuberidazole, fluopicolide, pencycuron, thiabendazole, thiophanate-methyl, zoxamide and chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl [1,2 ,4]triazolo[1,5-a]pyrimidine F3) Inhibitors of the respiratory chain complex I / II, e.g. B. diflumetorim, bixafen, boscalid, carboxin, diflumethorim fenfuram, fluopyram, flutolanil, furametpyr, mepronil, oxycarboxin, penflufen, penthiopyrad, thifluzamide, N-[2-(1,3-dimethylbutyl)phenyl]-5-fluoro-1, 3-dimethyl-1H-pyrazole-4-carboxamide, isopyrazam, sedaxane, 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)-1H-pyrazole-4 -carboxamide, 3-(Difluoromethyl)-1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1H-pyrazole-4-carboxamide, 3-(Difluoromethyl)-N-[4 -fluoro-2-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-1-methyl-1H-pyrazole-4-carboxamide, N-[1-(2,4-dichlorophenyl)-1- methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide and corresponding salts; F4) Complex III respiratory chain inhibitors, e.g. B.amisulbrom, azoxystrobin, cyazofamide, dimoxystrobin, enestrobin, famoxadone, fenamidone, fluoxastrobin, kresoximmethyl, metominostrobin, orysastrobin, pyraclostrobin, pyribencarb, picoxystrobin, trifloxystrobin, (2E)-2-(2-{[6-(3-chloro- 2-methylphenoxy)-5-fluoropyrimidin-4-yl]oxy}phenyl)-2-(methoxyimino)-N-methylethanamide, (2E)-2-(ethoxyimino)-N-methyl-2-(2-{[( {(1E)-1-[3-(trifluoromethyl)-phenyl]ethylidene}amino)oxy]methyl}phenyl)ethanamide and corresponding salts, (2E)-2-(methoxyimino)-N-methyl-2-{2- [(E)-({1-[3-(trifluoromethyl)phenyl]ethoxy}-imino)methyl]phenyl}ethanamide, (2E)-2-{2-[({[(1E)-1-(3- {[(E)-1-Fluoro-2-phenylethenyl]-oxy}phenyl)ethylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylethanamide, (2E)-2-{2-[ ({[(2E,3E)-4-(2,6-Dichlorophenyl)but-3-en-2-ylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N- methylethanamide, 2-Chloro-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)pyridine-3-carboxamide, 5-Methoxy-2-methyl-4-(2- {[({(1E)-1-[3-(trifluoromethyl)phenyl]ethylidene}amino)oxy]methyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one, 2 -Methyl {2-[({cyclopropyl[(4-methoxyphenyl)-imino]methyl}sulfanyl)methyl]phenyl}-3-methoxyacrylate, N-(3-Ethyl-3,5,5-trimethylcyclohexyl)-3- (formylamino)-2-hydroxybenzamide and corresponding salts; F5) decouplers, e.g. B. Dinocap, Fluazinam; F6) Inhibitors of ATP production, e.g. fentin acetate, fentin chloride, fentin hydroxide, silthiofam F7) inhibitors of amino acid and protein biosynthesis, e.g. andoprim, blasticidin-S, cyprodinil, kasugamycin, kasugamycin hydrochloride hydrate, mepanipyrim, pyrimethanil F8) inhibitors of signal transduction, e. B. fenpiclonil, fludioxonil, quinoxyfen F9) Inhibitors of fat and membrane synthesis, z. chlozolinate, iprodione, procymidone, vinclozolin, ampropylfos, potassium ampropylfos, edifenphos, iprobefos (IBP), isoprothiolane, pyrazophos, tolclofos-methyl, biphenyl, iodocarb, propamocarb, propamocarb hydrochloride F10) Inhibitors of ergosterol biosynthesis, e.g. B. Fenhexamid, Azaconazole, Bitertanol, Bromuconazole, Diclobutrazole, Difenoconazole, Diniconazole, Diniconazole-M, Etaconazole, Fenbuconazole, Fluquinconazole, Flusilazole, Flutriafol, Furconazole, Furconazole-cis, Hexaconazole, Imibenconazole, Ipconazole, Metconazole, Myclobutanil, Paclobutrazole, Penconazole, Propiconazole, Prothioconazole, Simeconazole, Spiroxamine, Tebuconazole, Triadimefon, Triadimenol, Triticonazole, Uniconazole, Voriconazole, Imazalil, Imazalil Sulfate, Oxpoconazole, Fenarimol, Flurprimidol, Nuarimol, Pyrifenox, Triforin, Pefurazoate, Prochloraz, Triflumizole, Viniconazole, Aldimorph, Dodemorph, Dodemorph Acetate, Fenpropimorph, Tridemorph, Fenpropidin, Naftifine, Pyributicarb, Terbinafine, 1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cycloheptanol, Methyl-1-(2,2-dimethyl- 2,3-dihydro-1H-inden-1-yl)-1H-imidazole-5-carboxylate, N'-{5-(difluoromethyl)-2-methyl-4-[3-(trimethylsilyl)propoxy]phenyl }-N-ethyl-N-methylimidoformamide, N-ethyl-N-methyl-N'-{2-methyl-5-(trifluoromethyl)-4-[3-(trimethylsilyl)pr opoxy]phenyl}imidoformamide and O -{1-[(4-methoxy-phenoxy)methyl]-2,2-dimethylpropyl}-1H-imidazole-1-carbothioate; F11) Inhibitors of cell wall synthesis, e.g. B. Benthiavalicarb, Bialaphos, Dimethomorph, Flumorph, Iprovalicarb, Polyoxins, Polyoxorim, Validamycin A F12) Inhibitors of melanin biosynthesis, e.g. g. capramide, diclocymet, fenoxanil, phthalid, pyroquilone, tricyclazole F13) resistance induction, e.g. B. Acibenzolar-S-methyl, probenazole, tiadinil F14) Multisite, e.g. B. Captafol, Captan, Chlorothalonil, Copper Salts such as: Copper Hydroxide, Copper Naphtenate, Copper Oxychloride, Copper Sulfate, Copper Oxide, Oxine Copper and Bordeaux Mixture, Dichlofluanide, Dithianone, Dodine, Dodine Free Base, Ferbam, Folpet, Fluorfolpet, Guazatine, Guazatine Acetate, Iminoctadine, Iminoctadinalbesylate, iminoctadintriacetate, man copper, mancozeb, maneb, metiram, metiram zinc, propineb, sulfur and sulfur preparations containing calcium polysulphide, thiram, tolylfluanid, zineb, ziram F15) Unknown mechanism, e.g. B. amibromdol, benthiazole, bethoxazine, capsimycin, carvone, quinomethionate, chlorpicrin, cufraneb, cyflufenamide, cymoxanil, dazomet, debacarb, diclomezine, dichlorphen, dicloran, difenzoquat, difenzoquat methyl sulphate, diphenylamine, ethaboxam, ferimzon, flumetover, flusulfamide, fluopicolide, fluoroimide , Fosatyl-Al, Hexachlorobenzene, 8-Hydroxyquinoline Sulfate, Iprodione, Irumamycin, Isotianil, Methasulphocarb, Metrafenone, Methyl Isothiocyanate, Mildiomycin, Natamycin, Nickel dimethyldithiocarbamate, Nitrothal-isopropyl, Octhilinone, Oxamocarb, Oxyfenthiin, Pentachlorophenol and Salts, 2-Phenylphenol and salts, piperaline, propanosine sodium, proquinazide, pyrrolonitrine, quintozen, tecloftalam, tecnazen, triazoxide, trichlamide, zarilamide and 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine, N-(4-chloro- 2-nitrophenyl)-N-ethyl-4-methyl-benzenesulfonamide, 2-amino-4-methyl-N-phenyl-5-thiazolecarboxamide, 2-chloro-N-(2,3-dihydro-1,1,3- trimethyl-1H-inden-4-yl)-3-pyridinecarboxamide, 3-[5-(4-chlorophenyl)-2,3-di methylisoxazolidin-3-yl]pyridine, cis -1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cycloheptanol, 2,4-dihydro-5-methoxy-2- methyl-4-[[[[1-[3-(trifluoromethyl)-phenyl]-ethylidene]-amino]-oxy]-methyl]-phenyl]-3H-1,2,3-triazol-3-one (185336 -79-2), methyl 1-(2,3-dihydro-2,2-dimethyl-1H-inden-1-yl)-1H-imidazole-5-carboxylate, 3,4,5-trichloro-2,6 -pyridinedicarbonitrile, methyl 2-[[[cyclopropyl[(4-methoxyphenyl)imino]methyl]thio]methyl]-.alpha.-(methoxymethylene)-benzacetate, 4-chloro-alpha-propynyloxy-N-[2-[3 - methoxy-4-(2-propynyloxy)phenyl]ethyl]benzacetamide, (2S)-N-[2-[4-[[3-(4-chlorophenyl)-2-propynyl]oxy]-3-methoxyphenyl] ethyl]-3-methyl-2-[(methylsulfonyl)amino]butanamide, 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)[1,2, 4]triazolo[1,5-a]pyrimidine, 5-chloro-6-(2,4,6-trifluorophenyl)-N-[(1R)-1,2,2-trimethylpropyl][1,2,4] triazolo[1,5-a]pyrimidine-7-amine, 5-chloro-N-[(1R)-1,2-dimethylpropyl]-6-(2,4,6-trifluorophenyl) [1,2,4] triazolo[1,5-a]pyrimidin-7-amine, N-[1-(5-bromo-3-chloropyri din-2-yl)ethyl]-2,4-dichloronicotinamide, N-(5-bromo-3-chloropyridin-2-yl)methyl-2,4-dichloronicotinamide, 2-butoxy-6-iodo-3- propyl-benzopyranon-4-one, N-{(Z)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl}-2-benzacetamide, N-(3-ethyl-3, 5,5-trimethylcyclohexyl)-3-formylamino-2-hydroxybenzamide, 2-[[[[1-[3(1Fluoro-2-phenylethyl)oxy]phenyl] ethylidene]amino]oxy]methyl]-alpha-(methoxyimino)-N-methyl-alphaE-benzacetamide, N-{2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2-( trifluoromethyl)benzamide, N-(3',4'-dichloro-5-fluorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, N-(6-methoxy-3 -pyridinyl)-cyclopropanecarboxamide, 1-[(4-Methoxyphenoxy)methyl]-2,2-dimethylpropyl-1H-imidazole-1-carboxylic acid, O-[1-[(4-Methoxyphenoxy)methyl]-2,2- dimethylpropyl]-1H-imidazol- 1-carbothioic acid, 2-(2-{[6-(3-Chloro-2-methylphenoxy)-5-fluoropyrimidin-4-yl]oxy}phenyl)-2-(methoxyimino)- N-methylacetamide bactericides: bronopol, dichlorphen, nitrapyrin, nickel dimethyldithiocarbamate, kasugamycin, octhilinone, furancarboxylic acid, oxytetracycline, probenazole, streptomycin, tecloftalam, copper sulfate and other copper preparations. Insecticides / acaricides / nematicides: The active ingredients mentioned here by their "common name" are known and are described, for example, in the pesticide manual ("The Pesticide Manual" 14th Ed., British Crop Protection Council 2006) or can be researched on the Internet (e.g. http://www .alanwood.net/pesticides). (1) Acetylcholinesterase (AChE) inhibitors such as carbamates, e.g. alanycarb, aldicarb, bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetate, furathiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, Pirimicarb, Propoxur, Thiodicarb, Thiofanox, Triazamate, Trimethacarb, XMC and Xylylcarb or organophosphates e.g. Acephate, Azamethiphos, Azinphos-ethyl, Azinphos-methyl, Cadusafos, Chlorethoxyfos, Chlorfenvinphos, Chlormephos, Chlorpyrifos, Chlorpyrifos-methyl, Coumaphos, Cyanophos, Demeton -S-methyl, diazinon, dichlorvos/DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, famphur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, imicyafos, isofenphos, isopropyl O-(methoxyaminothiophosphoryl) salicylate , Isoxathion, Malathion, Mecarbam, Methamidophos, Methidathion, Mevinphos, Monocrotophos, Naled, Omethoate, Oxydemeton-methyl, Parathion, Parathi on-methyl, Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidon, Phoxim, Pirimiphos-methyl, Profenofos, Propetamphos, Prothiofos, Pyraclofos, Pyridaphenthion, Quinalphos, Sulfotep, Tebupirimfos, Temephos, Terbufos, Tetrachlorvinphos, Thiometon, Triazophos, Triclorfon and Vamidothion. (2) GABA-gated chloride channel antagonists such as cyclodiene-organochlorins, e.g., Chlordane and Endosulfan, or phenylpyrazoles (Fiprole), e.g., Ethiprole and Fipronil. (3) Sodium channel modulators / voltage dependent sodium channel blockers such as pyrethroids e.g. acrinathrin, allethrin, d-cis-trans allethrin, d-trans allethrin, bifenthrin, bioallethrin, bioallethrin S-cyclopentenyl isomer, bioresmethrin, cycloprothrin , cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin [(1R)-trans isomers], deltamethrin, empenthrin [ (EZ)-(1R)-Isomers), Esfenvalerate, Etofenprox, Fenpropathrin, Fenvalerate, Flucythrinate, Flumethrin, Tau-Fluvalinate, Halfenprox, Imiprothrin, Kadethrin, Momfluorthrin, Permethrin, Phenothrin [(1R)-trans-Isomer), Prallethrin, Pyrethrins (pyrethrum), resmethrin, silafluofen, tefluthrin, tetramethrin, tetramethrin [(1R)-isomers)], tralomethrin and transfluthrin or DDT or methoxychlor. (4) Nicotinergic acetylcholine receptor (nAChR) agonists such as neonicotinoids, e.g., acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid and thiamethoxam or nicotine or sulfoxaflor or flupyradifurone. (5) Nicotinergic acetylcholine receptor (nAChR) allosteric activators such as spinosines, e.g., spinetoram and spinosad. (6) Chloride channel activators such as avermectins/milbemycins, e.g., abamectin, emamectin benzoate, lepimectin and milbemectin. (7) Juvenile hormone mimics such as juvenile hormone analogues, e.g., hydroprene, kinoprene and methoprene, or fenoxycarb or pyriproxyfen. (8) Drugs with unknown or non-specific mechanisms of action, such as alkyl halides, e.g., methyl bromide and other alkyl halides; or chloropicrine, or sulfuryl fluoride, or borax, or tartar emetic. (9) Selective feeding inhibitors, e.g., pymetrozine or flonicamid. (10) Mite growth inhibitors, e.g., Clofentezine, Hexythiazox and Diflovidazine or Etoxazole. (11) Microbial disruptors of insect gut membrane, e.g. Bacillus thuringiensis subsp. israelensis, Bacillus sphaericus, Bacillus thuringiensis subsp. aizawai, Bacillus thuringiensis subsp. kurstaki, Bacillus thuringiensis subsp /35Ab1. (12) Inhibitors of oxidative phosphorylation, ATP disruptors such as diafenthiuron or organotin compounds such as azocyclotin, cyhexatin and fenbutatin oxide or propargite or tetradifon. (13) Oxidative phosphorylation decouplers by disrupting the H-proton gradient, such as chlorfenapyr, DNOC, and sulfluramide. (14) Nicotinergic acetylcholine receptor antagonists such as Bensultap, Cartap hydrochloride, Thiocyclam and Thiosultap sodium. (15) Inhibitors of chitin biosynthesis type O such as bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron and triflumuron. (16) Inhibitors of chitin biosynthesis, type 1, such as buprofezin. (17) Moulting agents, dipteran, such as cyromazine. (18) Ecdysone receptor agonists such as chromafenozide, halofenozide, methoxyfenozide and tebufenozide. (19) Octopaminergic agonists such as amitraz. (20) Complex III electron transport inhibitors such as hydramethylnon or acequinocyl or fluacrypyrim. (21) Complex I electron transport inhibitors, for example METI acaricides, e.g., fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad and tolfenpyrad, or Rotenone (Derris). (22) Voltage-gated sodium channel blockers, e.g., indoxacarb or metaflumizone. (23) Inhibitors of acetyl-CoA carboxylase such as tetronic and tetramic acid derivatives, e.g., spirobudiclofen, spirodiclofen, spiromesifen and spirotetramat. (24) Complex IV electron transport inhibitors such as phosphines, e.g., aluminum phosphide, calcium phosphide, phosphine and zinc phosphide or cyanide. (25) Complex II electron transport inhibitors such as cyenopyrafen and cyflumetofen. (28) Ryanodine receptor effectors such as diamides, e.g., chlorantraniliproles, cyantraniliproles, flubendiamides and tetrachlorantraniliproles. Other active ingredients with an unknown or ambiguous mechanism of action, such as afidopyropene, afoxolaner, azadirachtin, benclothiaz, benzoximate, bifenazate, broflanilide, bromopropylate, quinomethionate, cryolite, cyclaniliprole, cycloxaprid, cyhalodiamide dicloromezotiaz, dicofol, diflovidazine, flometoquine, fluazaindolizine, fluensulfone, flufenerim, Flufenoxystrobin, Flufiprole, Fluhexafone, Fluopyram, Fluralaner, Fluxametamide, Fufenozide, Guadipyr, Heptafluthrin, Imidaclothiz, Iprodione, Lotilaner, Meperfluthrin, Paichongding, Pyflubumide, Pyridalyl, Pyrifluquinazone, Pyriminostrobin, Sarolaner, Tetramethylfluthrin, Tetraniliprole, Tetrachlorantraniliprole, Tioxazafen, and iodomethanes; also preparations based on Bacillus firmus (I-1582, BioNeem, Votivo), as well as the following known active compounds: 1-{2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl }-3-(trifluoromethyl)-1H-1,2,4-triazole-5-amine (known from WO2006/043635), {1'-[(2E)-3-(4-chlorophenyl)prop-2-ene -1-yl]-5-fluorospiro[indole-3,4'-piperidine]-1(2H)-yl}(2-chloropyridin-4-yl)methanone (known from WO2003/106457), 2-chloro-N -[2-{1-[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl]piperidin-4-yl}-4-(trifluoromethyl)phenyl]isonicotinamide (known from WO2006/003494 ), 3-(2,5-dimethylphenyl)-4-hydroxy-8-methoxy-1,8-diazaspiro[4.5]dec-3-en-2-one (known from WO2009/049851), 3-(2, 5-dimethylphenyl)-8-methoxy-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl ethyl carbonate (known from WO2009/049851), 4-(but-2-yn-1 -yloxy)-6-(3,5-dimethylpiperidin-1-yl)-5-fluoropyrimidine (known from WO2004/099160), 4-(but-2-yn-1-yloxy)-6-(3-chlorophenyl) pyrimidine (known from WO2003/076415), PF1364 (CAS-Reg.No.1204776-60-2), methyl-2-[2-({[3-bro m-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)-5-chloro-3-methylbenzoyl]-2-methylhydrazinecarboxylate (known from WO2005/085216), methyl-2 -[2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoyl]-2-ethylhydrazinecarboxylate (known from WO2005/085216), methyl-2-[2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3 -methylbenzoyl]-2-methylhydrazine carboxylate (known from WO2005/085216), methyl-2-[3,5-dibromo-2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole -5-yl]carbonyl}amino)benzoyl]-2-ethylhydrazinecarboxylate (known from WO2005/085216), N-[2-(5-amino-1,3,4-thiadiazol-2-yl)-4-chloro- 6-methylphenyl]-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide (known from CN102057925), 4-[5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methyl-N-(1-oxidothietan-3-yl)benzamide (known from WO2009/080250), N-[(2E) -1-[(6-Chloropyridin-3-yl)methyl]pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide (known from WO2 012/029672), 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-4-oxo-3-phenyl-4H-pyrido[1,2-a]pyrimidin-1-ium 2-olate (known from WO2009/099929), 1-[(6-chloropyridin-3-yl)methyl]-4-oxo-3-phenyl-4H-pyrido[1,2-a]pyrimidin-1-ium 2-olate (known from WO2009/099929), 4- (3-{2,6-Dichloro-4-[(3,3-dichloroprop-2-en-1-yl)oxy]phenoxy}propoxy)-2-methoxy-6-(trifluoromethyl)pyrimidine (known from CN101337940) , N-[2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl]-1-(3-chloropyridin-2-yl)-3-(fluoromethoxy)-1H-pyrazole-5-carboxamide (known from WO2008 /134969), butyl [2-(2,4-dichlorophenyl)-3-oxo-4-oxaspiro[4.5]dec-1-en-1-yl]-carbonate (known from CN 102060818), 3E)-3 -[1-[(6-Chloro-3-pyridyl)methyl]-2-pyridylidene]-1,1,1-trifluoro-propan-2-one (known from WO2013/144213), N-(methylsulfonyl)-6 -[2-(pyridin-3-yl)-1,3-thiazol-5-yl]pyridin-2-carboxamide (known from WO2012/000896), N-[3-(benzylcarbamoyl)-4-chlorophenyl]-1 -methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide (known from WO2010/051926), 5-bromo-4-chloro-N-[4-chloro-2-methyl-6 -(methylcarbamoyl)phenyl]-2-(3-chloro-2-pyridyl)pyrazole-3-carboxamide (known from CN103232431), tioxazafen, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro- 5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-(cis-1-oxido-3-thietanyl)benzamide, 4 -[5-(3,5-Dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-(trans-1-oxido-3-thietanyl)-benzamide and 4 -[(5S)-5-(3,5-Dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-(cis-1-oxido-3-thietanyl) benzamide (known from WO 2013050317 A1), N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulphinyl ]-propanamide, (+)-N-[3-Chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulfinyl] -propanamide and (-)-N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulfinyl]- propanamide (known from WO 2013162715 A2, WO 2013162716 A2, US 20140213448 A1), 5-[[(2E)-3-chloro-2-propen-1-yl]amino]-1-[2,6-dichloro-4 - (trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (known from CN 101337937 A), 3-bromo-N-[4-chloro-2-methyl-6-[( methylamino)thioxomethyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, (Liudaibenjiaxuanan, known from CN 103109816 A); N -[4-Chloro-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-3-(fluoromethoxy)-1H-pyrazole- 5-carboxamide (known from WO 2012034403 A1), N-[2-(5-amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methylphenyl]-3-bromo-1-( 3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide (known from WO 2011085575 A1), 4-[3-[2,6-dichloro-4-[(3,3-dichloro-2-propene- 1-yl)oxy]phenoxy]propoxy]-2-methoxy-6-(trifluoromethyl)-pyrimidine (known from CN 101337940 A); (2E)- and 2(Z)-2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylidene]-N-[4-(difluoromethoxy)phenyl]-hydrazinecarboxamide (known from CN 101715774 A); 3-(2,2-Dichloroethenyl)-2,2-dimethyl-4-(1H-benzimidazol-2-yl)phenyl cyclopropane carboxylic acid ester (known from CN 103524422 A); (4aS)-7-Chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-[(trifluoromethyl)thio]phenyl]amino]carbonyl]indeno[1,2-e][1,3, 4]oxadiazine-4a(3H)-carboxylic acid methyl ester (known from CN 102391261 A). Safeners are preferably selected from the group consisting of: S1) compounds of formula (S1),
Figure imgf000422_0001
where the symbols and indices have the following meanings: nA is a natural number from 0 to 5, preferably 0 to 3; RA1 is halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, nitro or (C1-C4)-haloalkyl; -
Figure imgf000422_0002
WA is an unsubstituted or substituted divalent heterocyclic radical from the group of saturated or aromatic five-membered ring heterocycles having 1 to 3 hetero ring atoms from the group N and O, where at least one N atom and at most one O atom is contained in the ring, preferably one Rest of the group (WA1) to (WA4), mA is 0 or 1; RA2 is ORA3, SRA3 or NRA3RA4 or a saturated or unsaturated 3- to 7-membered heterocycle having at least one N atom and up to 3 heteroatoms, preferably from the group O and S, which is connected to the carbonyl group in (S1) via the N atom and is unsubstituted or by residues from the group (C1-C4)-alkyl, (C1-C4)-alkoxy or optionally substituted phenyl, preferably a radical of the formula ORA3, NHRA4 or N(CH3)2, especially the formulaOR A 3; RA 3 is hydrogen or an unsubstituted or substituted aliphatic hydrocarbon radical, preferably having a total of 1 to 18 carbon atoms; RA 4 is hydrogen, (C1-C6)-alkyl, (C1-C6)-alkoxy or substituted or unsubstituted phenyl; RA 5 is H, (C1-C8th)-alkyl, (C1-C8th)-haloalkyl, (C1-C4)-alkoxy(C1-C8th)-alkyl, cyano or COORA 9, where RA 9 hydrogen, (C1-C8th)-alkyl, (C1-C8th)-haloalkyl, (C1-C4)-alkoxy-(C1-C4)-alkyl, (C1-C6)-hydroxyalkyl, (C3-C12)-cycloalkyl or tri-(C1-C4)-alkylsilyl; RA 6, RA 7, RA 8th are identical or different hydrogen, (C1-C8th)-alkyl, (C1-C8th)-haloalkyl, (C3-C12)-cycloalkyl or substituted or unsubstituted phenyl; preferably: a) Compounds of the dichlorophenylpyrazoline-3-carboxylic acid type (S1a), preferably compounds such as 1-(2,4-dichlorophenyl)-5-(ethoxycarbonyl)-5-methyl-2-pyrazoline-3-carboxylic acid, 1-(2,4-dichlorophenyl)-5-(ethoxycarbonyl)-5 -methyl-2-pyrazoline-3-carboxylic acid ethyl ester (S1-1) ("mefenpyr-diethyl"), and related compounds as described in WO-A-91/07874; b) Derivatives of dichlorophenylpyrazole carboxylic acid (S1b), preferably compounds such as ethyl 1-(2,4-dichlorophenyl)-5-methylpyrazole-3-carboxylate (S1-2), 1-(2,4-dichlorophenyl)-5-isopropylpyrazole-3- ethyl carboxylate (S1-3), ethyl 1-(2,4-dichlorophenyl)-5-(1,1-dimethylethyl)pyrazole-3-carboxylate (S1-4) and related compounds as described in EP -A-333131 and EP-A-269806; c) Derivatives of 1,5-diphenylpyrazole-3-carboxylic acid (S1c), preferably compounds such as ethyl 1-(2,4-dichlorophenyl)-5-phenylpyrazole-3-carboxylate (S1-5), methyl 1-(2-chlorophenyl)-5-phenylpyrazole-3-carboxylate (S1-6) and related ones compounds such as are described in EP-A-268554; d) compounds of the triazole carboxylic acid type (S1i.e), preferably compounds such as fenchlorazole (ethyl ester), i.e. ethyl 1-(2,4-dichlorophenyl)-5-trichloromethyl-(1H)-1,2,4-triazole-3-carboxylate (S1-7), and related compounds as described in EP-A-174562 and EP-A-346620; e) Compounds of the 5-benzyl or 5-phenyl-2-isoxazoline-3-carboxylic acid or 5,5-diphenyl-2-isoxazoline-3-carboxylic acid type (S1e), preferably compounds such as ethyl 5-(2,4-dichlorobenzyl)-2-isoxazoline-3-carboxylate (S1-8) or ethyl 5-phenyl-2-isoxazoline-3-carboxylate (S1-9) and related compounds such as them are described in WO-A-91/08202, or 5,5-diphenyl-2-isoxazoline-3-carboxylic acid (S1-10) or ethyl 5,5-diphenyl-2-isoxazoline-3-carboxylate (S1-11) ("Isoxadifen-ethyl") or -n-propyl ester (S1-12) or ethyl 5-(4-fluorophenyl)-5-phenyl-2-isoxazoline-3-carboxylate (S1-13) as described in patent application WO -A-95/07897. S2) quinoline derivatives of the formula (S2),
Figure imgf000423_0001
where the symbols and indices have the following meanings: RB1 is halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, nitro or (C1-C4)-haloalkyl; nB is a natural number from 0 to 5, preferably 0 to 3; RB2 is ORB3, SRB3 or NRA3RB4 or a saturated one or unsaturated 3- to 7-membered heterocycle having at least one N atom and up to 3 heteroatoms, preferably from the group O and S, which is connected to the carbonyl group in (S2) via the N atom and is unsubstituted or substituted by radicals of the group (C1-C4)-alkyl, (C1-C4)-alkoxy or optionally substituted phenyl, preferably a radical of the formula ORB 3, NHRB 4 or N(CH3)2, in particular the formula ORB 3; RB 3 is hydrogen or an unsubstituted or substituted aliphatic hydrocarbon radical, preferably having a total of 1 to 18 carbon atoms; RB4 is hydrogen, (C1-C6)-alkyl, (C1-C6)-alkoxy or substituted or unsubstituted phenyl; TB is a (C1 or c2)-alkanediyl chain which is unsubstituted or with one or two (C1-C4)- alkyl radicals or with [(C1-C3)-alkoxy]-carbonyl is substituted; preferably: a) compounds of the 8-quinolinoxyacetic acid type (S2a), preferably (5-chloro-8-quinolinoxy)acetic acid (1-methylhexyl) ester ("Cloquintocet-mexyl") (S2-1), (5-chloro-8-quinolinoxy)acetic acid (1,3-dimethyl -but-1-yl)ester (S2-2), (5-Chloro-8-quinolinoxy)acetic acid 4-allyloxy-butyl ester (S2-3), (5-Chloro-8-quinolinoxy)acetic acid-1 - allyloxy-prop-2-yl ester (S2-4), (5-chloro-8-quinolinoxy)acetic acid ethyl ester (S2-5), (5-chloro-8-quinolinoxy)acetic acid methyl ester (S2-6), (5 -Chloro-8-quinolinoxy)acetic acid allyl ester (S2-7), (5-Chloro-8-quinolinoxy)acetic acid 2-(2-propylidene-iminoxy)-1-ethyl ester (S2-8), (5-Chloro-8 - quinolinoxy)acetic acid 2-oxo-prop-1-yl ester (S2-9) and related compounds as described in EP-A-86750, EP-A-94349 and EP-A-191736 or EP-A-0492366 are, and (5-chloro-8-quinolinoxy) acetic acid (S2-10), its hydrates and salts, for example their lithium, sodium, potassium, calcium, magnesium, aluminum, iron, ammonium, quaternary Ammonium, sulfonium or phosphonium salts as described in WO-A-2002/34048 s ind; b) Compounds of the (5-chloro-8-quinolinoxy)malonic acid type (S2b), preferably compounds such as diethyl (5-chloro-8-quinolinoxy)malonate, diallyl (5-chloro-8-quinolinoxy)malonate, methyl ethyl (5-chloro-8-quinolinoxy)malonate and related compounds as described in EP A-0582198. S3) Compounds of formula (S3)
Figure imgf000424_0001
where the symbols and indices have the following meanings: RC 1 is (C1-C4)-alkyl, (C1-C4)-haloalkyl, (C2-C4)-alkenyl, (C2-C4)-haloalkenyl, (C3-C7)-cycloalkyl, preferably dichloromethyl; RC 2, RC 3 are identical or different hydrogen, (C1-C4)-alkyl, (C2-C4)-alkenyl, (C2-C4)-alkynyl, (C1-C4)-haloalkyl, (C2-C4)-haloalkenyl, (C1-C4)-alkylcarbamoyl-(C1-C4)-alkyl, (C2- C4)-alkenylcarbamoyl-(C1-C4)-alkyl, (C1-C4)-alkoxy-(C1-C4)-alkyl, dioxolanyl-(C1-C4)-alkyl, thiazolyl, furyl, furylalkyl, thienyl, piperidyl, substituted or unsubstituted phenyl, or RC 2 and RC 3 together form a substituted or unsubstituted heterocyclic ring, preferably an oxazolidine, thiazolidine, piperidine, morpholine, hexahydropyrimidine or benzoxazine ring; preferably: active ingredients of the dichloroacetamide type, which are often used as pre-emergence safeners (soil-effective safeners), such as e.g. B. "Dichlormide" (N,N-Diallyl-2,2-dichloroacetamide) (S3-1), "R-29148" (3-Dichloroacetyl-2,2,5-trimethyl-1,3-oxazolidine) from the company Stauffer (S3-2), "R-28725" (3-dichloroacetyl-2,2-dimethyl-1,3-oxazolidine) from Stauffer (S3-3), "Benoxacor" (4-dichloroacetyl-3,4 -dihydro-3-methyl-2H-1,4-benzoxazine) (S3-4), "PPG-1292" (N-allyl-N-[(1,3-dioxolan-2-yl)-methyl]-dichloroacetamide ) from PPG Industries (S3-5), "DKA-24" (N-allyl-N-(allylaminocarbonyl)methyl]-dichloroacetamide) from Sagro-Chem (S3-6), "AD-67" or " MON 4660" (3-dichloroacetyl-1-oxa-3-aza-spiro[4,5]decane) from Nitrokemia or Monsanto (S3-7), "TI-35" (1-dichloroacetyl-azepan) from the company TRI-Chemical RT (S3-8), "Diclonon" (Dicyclonone) or "BAS145138" or "LAB145138" (S3-9) ((RS)-1-Dichloroacetyl-3,3,8a-trimethylperhydropyrrolo[1,2- a]pyrimidin-6-one) from BASF, "Furilazol" or "MON 13900" ((RS)-3-dichloroacetyl-5-(2-furyl)-2,2-dimethyloxazolidine) (S3-10); and its (R)-isomer (S3-11). S4) N-acylsulfonamides of the formula (S4) and their salts,
Figure imgf000425_0001
wherein the symbols and indices have the following meanings: XD is CH or N; RD1 is CO-NRD5RD6 or NHCO-RD7; RD2 is halogen, (C1-C4)-haloalkyl, (C1-C4)-haloalkoxy, nitro, (C1-C4)-alkyl, (C1-C4)-alkoxy, (C1-C4)-alkylsulfonyl, (C1-C4)-alkoxycarbonyl or (C1-C4)-alkylcarbonyl; RD 3 is hydrogen, (C1-C4)-alkyl, (C2-C4)-alkenyl or (C2-C4)-alkynyl; RD 4 is halogen, nitro, (C1-C4)-alkyl, (C1-C4)-haloalkyl, (C1-C4)-haloalkoxy, (C3-C6)-cycloalkyl, phenyl, (C1-C4)-alkoxy, cyano, (C1-C4)-alkylthio, (C1-C4)-alkylsulphinyl, (C1-C4)-alkylsulfonyl, (C1-C4)-alkoxycarbonyl or (C1-C4)-alkylcarbonyl; RD 5 is hydrogen, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C5-C6)-cycloalkenyl, phenyl or 3- to 6-membered heterocyclyl containing vD Heteroatoms from the group consisting of nitrogen, oxygen and sulphur, the last seven radicals being replaced by vD substituents from the group consisting of halogen, (C1-C6)-alkoxy, (C1-C6)-haloalkoxy, (C1-C2)-alkylsulphinyl, (C1-C2)-alkylsulfonyl, (C3-C6)-cycloalkyl, (C1-C4)-alkoxycarbonyl, (C1-C4)- alkylcarbonyl and phenyl and in the case of cyclic radicals also (C1-C4)-alkyl and (C1-C4)-haloalkyl are substituted; RD6 is hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl or (C2-C6)-alkynyl, where the last three radicals are replaced by vD radicals from the group halogen, hydroxy, (C1-C4)-alkyl, (C1-C4)-alkoxy and (C1-C4)-alkylthio are substituted, or RD5 and RD6 together with the nitrogen atom carrying them form a pyrrolidinyl or piperidinyl radical; RD7 is hydrogen, (C1-C4)-alkylamino, di-(C1-C4)-alkylamino, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, where the 2 last-mentioned radicals are replaced by vD substituents from the group halogen, (C1-C4)-alkoxy, (C1-C6)-haloalkoxy and (C1-C4)-alkylthio and in the case of cyclic radicals also (C1-C4)-alkyl and (C1-C4)-haloalkyl; nD is 0, 1 or 2; mD is 1 or 2; vD is 0, 1, 2 or 3; Of these, preference is given to compounds of the N-acylsulfonamide type, e.g. of the following formula (S4a), the e.g. B. are known from WO-A-97/45016
Figure imgf000426_0001
wherein RD7 (C1-C6)-alkyl, (C3-C6)-cycloalkyl, where the 2 last-mentioned radicals are replaced by vD substituents from the group halogen, (C1-C4)-alkoxy, (C1-C6)-haloalkoxy and (C1-C4)-alkylthio and in the case of cyclic radicals also (C1-C4)-alkyl and (C1-C4)-haloalkyl; RD4 halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, CF3; mD 1 or 2; vD is 0, 1, 2 or 3; and acylsulfamoylbenzoic acid amides, e.g. of the following formula (S4b), which are known e.g. from WO-A-99/16744,
Figure imgf000427_0001
e.g. those in which RD 5 = cyclopropyl and (RD 4) = 2-OMe ("Cyprosulfamide", S4-1), RD 5 = cyclopropyl and (RD 4) = 5-Cl-2-OMe is (S4-2), RD 5 = ethyl and (RD 4) = 2-OMe is (S4-3), RD 5 = isopropyl and (RD 4) = 5-Cl-2-OMe is (S4-4) and RD 5 = isopropyl and (RD 4) = 2-OMe is (S4-5). and compounds of the N-acylsulfamoylphenylurea type of the formula (S4c), which are known e.g. from EP-A-365484,
Figure imgf000427_0002
wherein RD 8th and RD 9 independently hydrogen, (C1-C8th)-alkyl, (C3-C8th)-cycloalkyl, (C3-C6)-alkenyl, (C3-C6)-alkynyl, RD 4 halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, CF3 mD is 1 or 2; for example 1-[4-(N-2-methoxybenzoylsulfamoyl)phenyl]-3-methylurea, 1-[4-(N-2-methoxybenzoylsulfamoyl)phenyl]-3,3-dimethylurea, 1-[4-(N-4 ,5-dimethylbenzoylsulfamoyl)phenyl]-3-methylurea. S5) Active ingredients from the class of hydroxyaromatics and aromatic-aliphatic carboxylic acid derivatives (S5), e.g. ethyl 3,4,5-triacetoxybenzoate, 3,5-di-methoxy-4- hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 4-hydroxysalicylic acid, 4-fluorosalicylic acid, 2-hydroxycinnamic acid, 2,4-dichlorocinnamic acid, as described in WO-A-2004/084631, WO-A-2005/015994, WO-A- 2005/016001. S6) Active substances from the class of 1,2-dihydroquinoxalin-2-ones (S6), e.g. 1-methyl-3-(2-thienyl)-1,2-dihydroquinoxalin-2-one, 1-methyl-3-( 2-thienyl)-1,2-dihydroquinoxaline-2-thione, 1-(2-aminoethyl)-3-(2-thienyl)-1,2-dihydro-quinoxalin-2-one hydrochloride, 1-(2- Methylsulfonylaminoethyl)-3-(2-thienyl)-1,2-dihydroquinoxa-lin-2-one, as described in WO-A-2005/112630. S7) Compounds of the formula (S7) as described in WO-A-1998/38856
Figure imgf000428_0001
where the symbols and indices have the following meanings: RE 1, RE 2 are independently halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, (C1-C4)-haloalkyl, (C1-C4)-alkylamino, di-(C1-C4)-alkylamino, nitro; AE is COORE3 or COSRE4 RE3, R.E4 are independently hydrogen, (C1-C4)-alkyl, (C2-C6)-alkenyl, (C2-C4)-alkynyl, cyanoalkyl, (C1-C4)-haloalkyl, phenyl, nitrophenyl, benzyl, halobenzyl, pyridinylalkyl and alkylammonium, nE1 is 0 or 1 nE2, nE3 are independently 0, 1 or 2, preferably diphenylmethoxyacetic acid, diphenylmethoxyacetic acid ethyl ester, diphenylmethoxyacetic acid methyl ester (CAS Reg. No. 41858-19-9) (S7-1). S8) Compounds of formula (S8) as described in WO-A-98/27049 Worin
Figure imgf000428_0002
Xf CH or N, nf in the event that Xf=N is an integer from 0 to 4 and if Xf=CH is an integer from 0 to 5 , Rf 1 halogen, (C1-C4)-alkyl, (C1-C4)-haloalkyl, (C1-C4)-alkoxy, (C1-C4)-haloalkoxy, nitro, (C1-C4)-alkylthio, (C1-C4)-alkylsulfonyl, (C1-C4)-Alkoxycarbonyl, optionally substituted. Phenyl, optionally substituted phenoxy, RF2 hydrogen or (C1-C4)-alkyl RF3 hydrogen, (C1-C8th)-alkyl, (C2-C4)-alkenyl, (C2-C4)-alkynyl, or aryl, where each of the aforementioned C-containing radicals is unsubstituted or substituted by one or more, preferably up to three, identical or different radicals from the group consisting of halogen and alkoxy; mean, or their salts, preferably compounds in which XF CH, nF is an integer from 0 to 2, RF1 halogen, (C1-C4)-alkyl, (C1-C4)-haloalkyl, (C1-C4)-alkoxy, (C1-C4)-haloalkoxy, RF2 hydrogen or (C1-C4)-alkyl, RF3 hydrogen, (C1-C8th)-alkyl, (C2-C4)-alkenyl, (C2-C4)-Alkinyl, or aryl, where each of the aforementioned C-containing radicals is unsubstituted or substituted by one or more, preferably up to three, identical or different radicals from the group consisting of halogen and alkoxy, or their salts. S9) Active substances from the class of 3-(5-tetrazolylcarbonyl)-2-quinolones (S9), e.g. 1,2-dihydro-4-hydroxy-1-ethyl-3-(5-tetrazolylcarbonyl)-2-quinolone (CAS -Reg.Nr.219479-18-2), 1,2-dihydro-4-hydroxy-1-methyl-3-(5-tetrazolyl-carbonyl)-2-quinolone (CAS Reg.Nr.95855-00- 8) as described in WO-A-1999/000020. S10) Compounds of formulas (S10a) or (S10b) as described in WO-A-2007/023719 and WO-A-2007/023764
Figure imgf000430_0001
wherein RG 1 halogen, (C1-C4)-alkyl, methoxy, nitro, cyano, CF3, OCF3 YG, ZG independently O or S, nG an integer from 0 to 4, RG 2 (C1-C16)-alkyl, (C2-C6)-alkenyl, (C3-C6)-cycloalkyl, aryl; benzyl, halobenzyl, RG 3 hydrogen or (C1-C6)-alkyl. S11) Active substances of the type of oxyimino compounds (S11), which are known as seed dressings, such as. B. "Oxabetrinil" ((Z)-1,3-dioxolan-2-ylmethoxyimino(phenyl)acetonitrile) (S11-1) known as a seed dressing safener for millet against damage from metolachlor, "Fluxofenim" (1- (4-Chlorophenyl)-2,2,2-trifluoro-1-ethanone-O-(1,3-dioxolan-2-ylmethyl)-oxime) (S11-2) used as a seed dressing safener for sorghum against damage from metolachlor, and "Cyometrinil" or "CGA-43089" ((Z)-cyanomethoxyimino(phenyl)acetonitrile) (S11-3), which is known as a seed dressing safener for sorghum against damage from metolachlor. S12) Active substances from the class of isothiochromanone (S12), such as methyl [(3-oxo-1H-2-benzothiopyran-4(3H)-ylidene)methoxy]acetate (CAS Reg. No. 205121-04-6 ) (S12-1) and related compounds from WO-A-1998/13361. S13) One or more compounds from group (S13): "Naphthalic anhydride" (1,8-naphthalenedicarboxylic acid anhydride) (S13-1), known as a seed dressing safener for corn against damage from thiocarbamate herbicides, "Fenclorim" (4.6 -dichloro-2-phenylpyrimidine) (S13-2), known as a safener for pretilachlor in seeded rice, "Flurazole" (benzyl 2-chloro-4-trifluoromethyl-1,3-thiazole-5-carboxylate) (S13 -3) known as a seed dressing safener for millet against damage from alachlor and metolachlor, "CL 304415" (CAS Reg.No.31541-57-8) (4-carboxy-3,4-dihydro-2H- 1- benzopyran-4-acetic acid) (S13-4) from American Cyanamid, which is known as a safener for corn against damage from imidazolinones, "MG 191" (CAS Reg. No. 96420-72-3) (2- Dichloromethyl-2-methyl-1,3-dioxolane) (S13-5) from Nitrokemia, which is known as a safener for corn, "MG-838" (CAS Reg. No. 133993-74-5) (2- propenyl 1-oxa-4-azaspiro[4.5]decane-4-carbodithioate) (S13-6) from Nitrokemia, "Disulfoton" (O,O-diethyl S-2-ethylthioeth yl phosphorodithioate) (S13-7), "Dietholate" (O,O-diethyl-O-phenylphosphorothioate) (S13-8), "Mephenate" (4-chlorophenyl methylcarbamate) (S13-9). S14) active ingredients which, in addition to having a herbicidal action against harmful plants, also have a safener effect on crop plants such as rice, such as, for. B. "Dimepiperate" or "MY-93" (S-1-methyl-1-phenylethyl-piperidine-1-carbothioate), which is known as a safener for rice against damage from the herbicide Molinate, "Daimuron" or "SK 23" (1-(1-Methyl-1-phenylethyl)-3-p-tolyl-urea), known as a rice safener against damage from the herbicide imazosulfuron, "Cumyluron" = "JC-940" (3-(2- chlorophenylmethyl)-1-(1-methyl-1-phenylethyl)urea, see JP-A-60087254) known as a safener for rice against damage from some herbicides, "methoxyphenone" or "NK 049" (3.3 '-dimethyl-4-methoxy-benzophenone) known as a safener for rice against damage from some herbicides, "CSB" (1-bromo-4-(chloromethylsulfonyl)benzene) from Kumiai, (CAS Reg.No.54091- 06-4), which is known as a safener against damage from some herbicides in rice. S15) Compounds of the formula (S15) or their tautomers as described in WO-A-2008/131861 and WO-A-2008/131860 in which
Figure imgf000431_0001
RH 1 one (C1-C6)-haloalkyl radical and RH 2 is hydrogen or halogen and RH 3, RH 4 independently hydrogen, (C1-C16)-alkyl, (C2-C16)-alkenyl or (C2-C16)-alkynyl, each of the last-mentioned 3 radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxy, cyano, (C1-C4)-alkoxy, (C1-C4)-haloalkoxy, (C1-C4)-alkylthio, (C1-C4)-alkylamino, di[(C1-C4)-alkyl]-amino, [(C1-C4)-alkoxy]-carbonyl, [(C1-C4)-haloalkoxy]-carbonyl, (C3-C6)-cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted, or (C3-C6)-cycloalkyl, (C4-C6)-cycloalkenyl, (C3-C6)-cycloalkyl fused at one side of the ring with a 4 to 6-membered saturated or unsaturated carbocyclic ring, or (C4-C6)-cycloalkenyl fused at one side of the ring with a 4 to 6-membered saturated or unsaturated carbocyclic ring, each of the latter 4 radicals being unsubstituted or substituted by one or more radicals from the group halo, hydroxy, cyano, (C1-C4)-alkyl, (C1-C4)-haloalkyl, (C1-C4)-alkoxy, (C1-C4)-haloalkoxy, (C1-C4)-alkylthio, (C1-C4)-alkylamino, di[(C1-C4)-alkyl]-amino, [(C1-C4)alkoxy]-carbonyl, [(C1-C4)-haloalkoxy]-carbonyl, (C3-C6)-cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted is or R H3 (C1-C4)-alkoxy, (C2-C4)-alkenyloxy, (C2-C6)-alkynyloxy or (C2-C4)-haloalkoxy and RH4 hydrogen or (C1-C4)-alkyl or RH3 and R.H4 together with the directly bonded N atom, a four- to eight-membered heterocyclic ring which, in addition to the N atom, can also contain further hetero ring atoms, preferably up to two further hetero ring atoms from the group N, O and S, and which is unsubstituted or by one or more Residues from the group halogen, cyano, nitro, (C1-C4)-alkyl, (C1-C4)-haloalkyl, (C1-C4)-alkoxy, (C1-C4)-haloalkoxy and (C1-C4)-alkylthio is substituted. S16) Active ingredients which are primarily used as herbicides but also have a safener effect on crop plants, e.g. (2,4-dichlorophenoxy)acetic acid (2,4-D), (4-chlorophenoxy)acetic acid, (R,S)-2- (4-Chloro-o-tolyloxy)propionic acid (Mecoprop), 4-(2,4-dichlorophenoxy)butyric acid (2,4-DB), (4-chloro-o-tolyloxy)acetic acid (MCPA), 4-( 4-Chloro-o-tolyloxy)butyric acid, 4-(4-chlorophenoxy)butyric acid, 3,6-dichloro-2-methoxybenzoic acid (dicamba), 1-(ethoxycarbonyl)ethyl 3,6-dichloro-2-methoxybenzoate ( lactidichloro-ethyl). Substances influencing plant maturity: As combination partners for the compounds of general formula (I) in mixture formulations or in the tank mix are, for example, known active substances which are based on an inhibition of, for example, 1-aminocyclopropane-1-carboxylate synthase, 1-aminocyclopropane-1-carboxylate oxidase and the ethylene receptors, e.g. B. ETR1, ETR2, ERS1, ERS2 or EIN4, can be used, as z. B. in Biotechn. Adv. 2006, 24, 357-367; Bot. Bull. Acad. Sin.199, 40, 1-7 or Plant Growth Reg.1993, 13, 41-46 and the literature cited there. Known substances that influence plant maturity and which can be combined with the compounds of the general formula (I) include, for example, the following active ingredients (the compounds are either given the "common name" according to the International Organization for Standardization (ISO) or indicated by the chemical name or by the code number) and always include all application forms such as acids, salts, esters and isomers such as stereoisomers and optical isomers. One and sometimes several application forms are mentioned as an example: rhizobitoxin, 2-amino-ethoxy-vinylglycine (AVG), methoxyvinylglycine (MVG), vinylglycine, aminooxyacetic acid, sinefungin, S-adenosylhomocysteine, 2-keto-4-methylthiobutyrate, (isopropylidene )-aminooxyacetic acid 2-(methoxy)-2-oxoethyl ester, (isopropylidene)-aminooxyacetic acid 2-(hexyloxy)-2-oxoethyl ester, (cyclohexylidene)-aminooxyacetic acid 2-(isopropyloxy)-2-oxoethyl ester, putrescine, spermidine, Spermine, 1,8-diamino-4-aminoethyloctane, L-canalin, daminozide, 1-aminocyclopropyl-1-carboxylic acid methyl ester, N-methyl-1-aminocyclopropyl-1-carboxylic acid, 1-aminocyclopropyl-1-carboxamide, substituted 1 -aminocyclopropyl-1-carboxylic acid derivatives as described in DE3335514, EP30287, DE2906507 or US5123951, 1-aminocyclopropyl-1-hydroxamic acid, 1-methylcyclopropene, 3-methylcyclopropene, 1-ethylcyclopropene, 1-n-propylcyclopropene, 1-cyclopropenyl-methanol , Carvone, Eugenol, Sodium Cycloprop-1-en-1-yl Acetate, Natr iumcycloprop-2-en-1-yl acetate, sodium 3-(cycloprop-2-en-1-yl)propanoate, sodium 3-(cycloprop-1-en-1-yl)propanoate, jasmonic acid, jasmonic acid methyl ester, jasmonic acid ethyl ester, Prohydrojasmon, 2-Fluoro-N-(3-methoxyphenyl)-9H-purine-6-amine. Substances influencing plant health and germination: As combination partners for the compounds of the general formula (I) in mixture formulations or in the tank mix, for example, known active substances that influence plant health or germination can be used (the compounds are either identified by the "common name" after of the International Organization for Standardization (ISO) or with the chemical name or with the code number and always include all application forms such as acids, salts, esters and isomers such as stereoisomers and optical isomers): sarcosine, phenylalanine, tryptophan, N'-methyl-1 - phenyl-1-N,N-diethylaminomethanesulfonamide, apio-galacturonanes as described in WO2010017956, 4-oxo-4-[(2-phenylethyl)amino]butanoic acid, 4-{[2-(1H-indole-3- yl)ethyl]amino}-4-oxobutanoic acid, 4-[(3-methylpyridin-2-yl)amino]-4-oxobutanoic acid, allantoin, 5-aminolevulinic acid, (2S,3R)-2-(3,4-dihydroxyphenyl )-3,4-dihydro-2H-chromene-3,5,7-triol and structurally v related catechins as described in WO2010122956, 2-hydroxy-4-(methylsulfanyl)butanoic acid, (3Ε,3αR,8βS)-3-({[(2R)-4-methyl-5-oxo-2,5-dihydrofuran -2-yl]oxy}methylene)-3,3α,4,8β-tetrahydro-2H-indeno[1,2-b]furan-2-one and analogous lactones as described in EP2248421, abscisic acid, (2Z, 4E)-5-[6-ethynyl-1-hydroxy-2,6-dimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, methyl (2Z,4E) -5-[6-ethynyl-1-hydroxy-2,6-dimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoate, 4-phenylbutyric acid, sodium 4-phenylbutanoate , Potassium 4-phenylbutanoate. Herbicides or plant growth regulators: as combination partners for the compounds of general formula (I) in mixture formulations or in the tank mix are, for example, known active substances which are based on an inhibition of, for example, acetolactate synthase, acetyl-CoA carboxylase, cellulose synthase, enolpyruvylshikimate-3 -phosphate synthase, glutamine synthetase, p-hydroxyphenylpyruvate dioxygenase, phytoene desaturase, photosystem I, photosystem II, protoporphyrinogen oxidase or act as plant growth regulators, such as those from Weed Research 26 (1986) 441-445 or "The Pesticide Manual", 14th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2006 and references cited therein. As known herbicides or plant growth regulators which can be combined with compounds of the general formula (I), the following active ingredients are to be mentioned, for example (the compounds are either identified by the "common name" according to the International Organization for Standardization (ISO) or by the chemical name or denoted by the code number) and always include all application forms such as acids, salts, esters and isomers such as stereoisomers and optical isomers. One and sometimes also several application forms are mentioned as examples: acetochlor, acifluorfen, acifluorfen-methyl, acifluorfen-sodium, aclonifen, alachlor, allidochlor, alloxydim, alloxydim-sodium, ametryn, amicarbazone, amidochlor, amidosulfuron, 4-amino-3- Chloro-6-(4-chloro-2-fluoro-3-methylphenyl)-5-fluoropyridine-2-carboxylic acid, Aminocyclopyrachlor, Aminocyclopyrachlor-potassium, Aminocyclopyrachlor-methyl, Aminopyralid, Aminopyralid- dimethylammonium, Aminopyralid-tripromine, Amitrole, Ammonium sulfamate, Anilofos, Asulam, Asulam Potassium, Asulam Sodium, Atrazine, Azafenidin, Azimsulfuron, Beflubutamide, (S)-(-)- Beflubutamide, Beflubutamide-M, Benazolin, Benazolin-ethyl, Benazolin-dimethylammonium, Benazolin-Klaium, Benfluralin, Benfuresate, Bensulfuron, Bensulfuron-methyl, Bensulide, Bentazone, Bentazone-Sodium, Benzobicyclon, Benzofenap, Bicyclopyrone, Bifenox, Bilanafos, Bilanafos-Natium, Bipyrazone, Bispyribac, Bispyribac-Natium, Bixlozone, Bromacil, Bromacil-lithium, Bromacil - Sodium, bromobutide, bromofenoxime, bromoxynil, bromoxynil butyrate, bromoxynil potassium, bromoxynil heptanoate and bromoxynil octanoate, busoxinone, butachlor, butafenacil, butamifos, butenachlor, butraline, butroxydim, butylate, cafenstrol, cambendichlor, carbetamide, carfentrazone, carfentrazone-ethyl , chloramben, chloramben ammonium, chloramben diolamine, chlroamben methyl, chloramben methyl ammonium, chloramben natium, chlorbromuron, chlorfenac, chlorfenac ammonium, chlorfenac natium, chlorfenprop, chlorfenprop methyl, chlorflurenol, chlorflurenol methyl, chloridazon, chlorimuron , chlorimuron-ethyl, chlorphthalim, chlortoluron, chlorosulfuron, chlorthal, chlorthal-dimethyl, chlorthal-monomethyl, cinidon, cinidon-ethyl, cinmethylin, exo-(+)-cinmethylin, i.e. (1R,2S,4S)-4-isopropyl-1-methyl-2-[(2-methylbenzyl)oxy]-7-oxabicyclo[2.2.1]heptane, exo-(-)- cinmethyline, i.e. (1R,2S,4S)-4-isopropyl-1-methyl-2-[(2-methylbenzyl)oxy]-7-oxabicyclo[2.2.1]heptane, Cinosulfuron, Clacyfos, Clethodim, Clodinafop, Clodinafop-ethyl, Clodinafop -propargyl, clomazone, clomeprop, clopyralid, clopyralid-methyl, clopyralid-olamine, clopyralid-potassium, clopyralid-tripomine, cloransulam, cloransulam-methyl, cumyluron, cyanamide, cyanazine, cycloate, cyclopyranil, cyclopyrimorate, cyclosulfamuron, cycloxydim, cyhalofop, cyhalofop -butyl, cyprazine, 2,4-D (as well as the ammonium, butotyl, butyl, choline, diethylammonium, dimethylammonium, diolamine, doboxyl, dodecylammonium, etexyl, ethyl, 2-ethylhexyl, heptylammonium, isobutyl, isooctyl, isopropyl, isopropylammonium, lithium , meptyl, methyl, potassium, tetradecylammonium, triethylammonium, triisopropanolammonium, tripromine and trolamine salts thereof), 2,4-DB, 2,4-DB-butyl, 2,4-DB-dimethylammonium, 2,4-DB-isooctyl, 2,4DB Potassium and 2,4DB Sodium, Daimuron (Dymron), Dalapon, Dalapon Calcium, Dalapon Magnesium, Dalapon Natium, Dazomet, Dazomet- Sodium, n-decanol, 7-deoxy-D-sedoheptulose, desmedipham, detosyl-pyrazolate (DTP), dicamba and its salts (e.g. Dicamba-biproamine, Dicamba-N,N-bis(3-aminopropyl)methylamine, Dicamba- butotyl, Dicamba-choline, Dicamba-Diglycolamine, Dicamba-dimethylammonium, Dicamba- Diethanolaminemmonium, Dicamba-Diethylammonium, Dicamba-isopropylammonium, Dicamba-methyl, dicamba monoethanolamine, dicamba olamine, dicamba potassium, dicamba sodium, dicamba triethanolamine), dichlobenil, 2-(2,4-dichlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, 2 -(2,5-Dichlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, Dichloroprop, Dichloropropbutotyl, Dichloropropdimethylammonium, Dichloropropetexyl, Dichloropropethylammonium, Dichloropropisoctyl, Dichloropropmethyl , Dichloroprop Potassium, Dichloroprop Sodium, Dichloroprop-P, Dichloroprop-P-dimethylammonium, Dichlorprop-P-etexyl, Dichlorprop-P-potassium, Dichloroprop-Sodium, Diclofop, Diclofop-methyl, Diclofop-P, Diclofop-P-methyl , Diclosulam, Difenzoquat, Difenzoquat-metilsulfate, Diflufenican, Diflufenzopyr, Diflufenzopyr Sodium, Dimefuron, Dimepiperate, Dimesulfazet, Dimethachlor, D imethametryn, Dimethenamid, Dimethenamid-P, Dimetrasulfuron, Dinitramine, Dinoterb, Dinoterb-Acetate, Diphenamid, Diquat, Diquat-Dibromide, Diquat-Dichloride, Dithiopyr, Diuron, DNOC, DNOC-Ammonium, DNOC-Potassium, DNOC-Sodium, Endothal, Endothal- Diammonium, Endothal-Dipotassium, Endothal-Disodium, Epyrifenacil (S-3100), EPTC, Esprocarb, Ethalfluralin, Ethametsulfuron, Ethametsulfuron-Methyl, Ethiozine, Ethofumesate, Ethoxyfen, Ethoxyfen-Ethyl, Ethoxysulfuron, Etobenzanide, F-5231, i.e. N -[2-Chloro-4-fluoro-5-[4-(3-fluoropropyl)-4,5-dihydro-5-oxo-1H-tetrazol-1-yl]-phenyl]-ethanesulfonamide, F-7967, i.e. 3-[7-Chloro-5-fluoro-2-(trifluoromethyl)-1H-benzimidazol-4-yl]-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, Fenoxaprop , Fenoxaprop-P, Fenoxaprop-Ethyl, Fenoxaprop-P-Ethyl, Fenoxasulfone, Fenpyrazone, Fenquinotrione, Fentrazamid, Flamprop, Flamprop-Isoproyl, Flamprop-Methyl, Flamprop-M-Isopropyl, Flamprop-M-Methyl, Flazasulfuron, Florasulam, Florpyrauxifen , Florpyrauxifen-Benzyl, Fluazifop, Fluazifop-Butyl, Fluazifop-Methyl, Fluazifop-P, Fluazifop-P-Butyl, Flucarbazone, Flucarbazone-sodium, Flucetosulfuron, Fluchloraline, Flufenacet, Flufenpyr, Flufenpyr-Ethyl, Flumetsulam, Flumiclorac, Flumiclorac-Pentyl , flumioxazine, fluometuron, flurenol, flurenol-butyl, - dimethylammonium and methyl, fluoroglycofen, fluoroglycofen ethyl, flupropanate, flupropanate sodium, flupyrsulfuron, flupyrsulfuron methyl, flupyrsulfuron methyl sodium, fluridone, flurochloridone, fluroxypyr, fluroxypyr butometyl, fluroxypyr meptyl, flurtamone, fluthiacet, fluthiacet methyl , Fomesafen, Fomesafen Sodium, Foramsulfuron, Foramsulfuron Sodium, Fosamine, Fosamine Ammonium, Glufosinate, Glufosinate Ammonium, Glufosinate Sodium, L-Glufosinate Ammonium, L-Glufosinate Sodium, Glufosinate P Sodium, Glufosinate P -Ammonium, glyphosate, glyphosate ammonium, glyphosate isopropylammonium, glyphosate diammonium, glyphosate dimethylammonium, glyphosate potassium, glyphosate sodium, glyphosate sesquinodium and glyphosate trimesium, H-9201, i.e. O-(2,4-dimethyl-6-nitrophenyl)-O-ethyl isopropylphosphoramidothioate, Halauxifen, Halauxifen-methyl, Halosafen, Halosulfuron, Halosulfuron-Methyl, Haloxyfop, Haloxyfop- P, Haloxyfop-Ethoxyethyl, Haloxyfop-P-Ethoxyethyl, Haloxyfop-Methyl, Haloxyfop-P-Methyl, Haloxifop Sodium, Hexazinone, HNPC-A8169, i.e. Prop-2-yn-1-yl (2S)-2-{3-[(5-tert-butylpyridin-2-yl)oxy]phenoxy}propanoate, HW-02, i.e.1-(Dimethoxyphosphoryl)-ethyl-( 2,4-dichlorophenoxy)acetate, hydantocidin, imazamethabenz, imazamethabenz-methyl, imazamox, imazamox-ammonium, imazapic, imazapic-ammonium, imazapyr, imazapyr-isopropylammonium, imazaquin, imazaquin-ammonium, imazaquin-methyl, imazethapyr, imazethapyr-ammonium, Imazosulfuron, Indanofan, Indaziflam, Iodosulfuron, Iodosulfuron-Methyl, Iodosulfuron-Methyl-Sodium, Ioxynil, Ioxynil-Lithium, -octanoate, -potassium and sodium, Ipfencarbazone, Isoproturon, Isouron, Isoxaben, Isoxaflutole, Karbutylate, KUH-043, i.e.3 -({[5-(Difluoromethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}sulfonyl)-5,5-dimethyl-4,5-dihydro-1,2-oxazole , Ketospiradox, Ketospiradox Potassium, Lactofen, Lenacil, Linuron, MCPA, MCPA-Butotyl, -butyl, -dimethylammonium, -diolamine, -2- ethylhexyl, -ethyl, -isobutyl, isoctyl, -isopropyl, -isopropylammonium, -methyl, Olamine, -potassium, -sodium and -trolamine, MCPB , MCPB Methyl, Ethyl and Sodium, Mecoprop, Mecoprop Butotyl, Mecoprop dimethylammonium, Mecoprop Diolamine, Mecoprop Etexyl, Mecoprop Ethadyl, Mecoprop Isoctyl, Mecoprop Methyl, Mecoprop Potassium, Mecoprop Sodium, and Mecoprop Trolamine, Mecoprop-P, Mecoprop-P-Butotyl, -dimethylammonium, -2-ethylhexyl and -potassium, Mefenacet, Mefluidide, Mefluidide Diolamine, Mefluidide Potassium, Mesosulfuron, Mesosulfuron Methyl, Mesosulfuron Sodium, Mesotrione, Methhabenzthiazuron , Metam, Metamifop, Metamitron, Metazachlor, Metazosulfuron, Methhabenzthiazuron, Methiopyrsulfuron, Methiozoline, Methyl isothiocyanate, Metobromuron, Metolachlor, S-Metolachlor, Metosulam, Metoxuron, Metribuzin, Metsulfuron, Metsulfuron-Methyl, Molinate, Monolinuron, Monosulfuron, Monosulfuron-Methyl, MT-5950, i.e. N -[3-Chloro-4-(1-methylethyl)phenyl]-2-methylpentanamide, NGGC-011, Napropamide, NC-310, i.e. 4-(2,4-dichlorobenzoyl)-1-methyl-5-benzyloxypyrazole , NC-656, i.e. 3-[(Isopropylsulfonyl)methyl]-N-(5-methyl-1,3,4-oxadiazol-2-yl)-5-(trifluoromethyl)[1,2,4]triazolo-[4,3-a] Pyridine-8-carboxamide, Neburon, Nicosulfuron, Nonanoic Acid (Pelargonic Acid), Norflurazon, Oleic Acid (Fatty Acids), Orbencarb, Orthosulfamuron, Oryzalin, Oxadiargyl, Oxadiazon, Oxasulfuron, Oxaziclomefone, Oxyfluorfen, Paraquat, Paraquat Dichloride, Paraquat Dimethyl Sulfate, Pebulate, Pendimethalin, Penoxsulam, Pentachlorophenol, Pentoxazone, Pethoxamide, Petroleum Oil, Phenmedipham, Phenmedipham Ethyl, Picloram, Picloram dimethylammonium, Picloram etexyl, Picloram isoctyl, Picloram methyl, Picloram olamine, Picloram potassium, Picloram triethylammonium, Picloram Tripromin, Picloram-Trolamine, Picolinafen, Pinoxaden, Piperophos, Pretilachlor, Primisulfuron, Primisulfuron-Methyl, Prodiamine, Profoxydim, Prometon, Prometryn, Propachlor, Propanil, Propaquizafop, Propazine, Propham, Propisochlor, Propoxycarbazone, Propoxycarbazone-Sodium, Propyrisulfuron, Propyzamide, Prosulfocarb, Prosulfuron, Pyraclonil, Pyraflufen, Pyraflufen Ethyl, Pyrasulfotol, Pyrazolynate (Pyrazolate), Pyrazosulfuron, Pyrazosulfuron Ethyl, Pyrazoxyfen, Pyribambenz, Pyribambenz Isopropyl, Pyribambenz Propyl, Pyribenzoxim, Pyributicarb, Pyridafol, Pyridate, Pyriftalid, Pyriminobac, Pyriminobac -Methyl, pyrimisulfan, pyrithiobac, pyrithiobac sodium, pyroxasulfone, pyroxsulam, quinclorac, quinclorac dimethylammon ium, Quinclorac-Methyl, Quinmerac, Quinoclamine, Quizalofop, Quizalofop-Ethyl, Quizalofop-P, Quizalofop-P-Ethyl, Quizalofop-P-Tefuryl, QYM201, i.e.1-{2-Chloro-3-[(3-cyclopropyl- 5-hydroxy-1-methyl-1H-pyrazol-4-yl)carbonyl]-6-(trifluoromethyl)phenyl}piperidin-2-one, Rimsulfuron, Saflufenacil, Sethoxydim, Siduron, Simazine, Simetryn, SL-261, Sulcotrione, Sulfentrazone, Sulfometuron, Sulfometuron-Methyl, Sulfosulfuron, , SYP-249, i.e.1-Ethoxy-3-methyl-1-oxobut-3-en-2-yl-5-[2-chloro-4-(trifluoromethyl) phenoxy]-2-nitrobenzoate, SYP-300, i.e. 1-[7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzoxazine -6-yl]-3-propyl-2-thioxoimidazolidine-4,5-dione, 2,3,6-TBA, TCA (trichloroacetic acid) and its salts, e.g., TCA-ammonium, TCA-calcium, TCA-ethyl, TCA - Magnesium, TCA Sodium, Tebuthiuron, Tefuryltrione, Tembotrione, Tepraloxydim, Terbacil, Terbucarb, Terbumetone, Terbuthylazine, Terbutryn, Tetflupyrolimet, Thaxtomin, Thenylchlor, Thiazopyr, Thiencarbazone, Thiencarbazone-Methyl, Thifensulfuron, Thife nsulfuron-methyl, thiobencarb, tiafenacil, tolpyralate, topramezone, tralkoxydim, triafamon, tri-allate, triasulfuron, triaziflam, tribenuron, tribenuron-methyl, triclopyr, triclopyr-butotyl, triclopyr-choline, triclopyr-ethyl, triclopyr-triethylammonium, trietazine, Trifloxysulfuron, Trifloxysulfuron Sodium, Trifludimoxazine, Trifluralin, Triflusulfuron, Triflusulfuron Methyl, Tritosulfuron, Urea Sulfate, Vernolate, XDE-848, ZJ-0862, i.e.3,4-Dichloro-N-{2-[(4,6-dimethoxypyrimidine- 2-yl)oxy]benzyl}aniline, 3-(2-Chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-3,6-dihydropyrimidin-1(2H)-yl )phenyl)-5-methyl-4,5-dihydroisoxazole-5-carboxylic acid ethyl ester, Ethyl [(3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl )-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}pyridin-2-yl)oxy]acetate, 3-chloro-2-[3-(difluoromethyl)isoxazolyl-5-yl]phenyl-5-chloropyrimidine -2-yl ether, 2-(3,4-dimethoxyphenyl)-4-[(2-hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-6-methylpyridazine-3(2H)-one, 2 -({2-[(2-Methoxyethoxy)m ethyl]-6-methylpyridin-3-yl}carbonyl)cyclohexane-1,3-dione, (5-Hydroxy-1-methyl-1H-pyrazol-4-yl)(3,3,4-trimethyl-1,1 -dioxido-2,3-dihydro-1-benzothiophen-5-yl)methanone, 1-methyl-4-[(3,3,4-trimethyl-1,1-dioxido-2,3-dihydro-1-benzothiophene -5-yl)carbonyl]-1H-pyrazol-5-ylpropane-1-sulfonate, 4-{2-chloro-3-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4 -(methylsulfonyl)benzoyl}-1-methyl-1H-pyrazol-5-yl-1,3-dimethyl-1H-pyrazole-4-carboxylate; Cyanomethyl-4-amino-3-chloro-5-fluoro-6-(7- fluoro-1H-indol-6-yl)pyridine-2-carboxylate, prop-2-yn-1-yl 4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6- yl)pyridine-2-carboxylate, methyl 4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylate, 4-amino-3-chloro -5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylic acid, benzyl-4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indole -6-yl)pyridine-2-carboxylate, Ethyl 4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylate, Methyl-4- amino-3-chloro-5-fluoro-6-(7-fluoro-1-isobutyryl-1H-indol-6-yl)pyridine-2-carboxylate, methyl 6-(1-acetyl-7-fluoro-1H-indole -6-yl)-4-amino-3-chloro-5-fluoropyridine-2-carboxylate, methyl 4-amino-3-chloro-6-[1-(2,2-dimethylpropanoyl)-7-fluoro-1H -indol-6-yl]-5-fluoropyridine-2-carboxylate, methyl 4-amino-3-chloro-5-fluoro-6-[7-fluoro-1-(methoxyacetyl)-1H-indol-6-yl ]pyridine-2-carboxylate, potassium 4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylate, sodium 4-amino-3-chloro -5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylate, butyl 4-am ino -3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylate, 4-hydroxy-1-methyl-3-[4-(trifluoromethyl)pyridine-2 -yl]imidazolidin-2-one, 3-(5-tert-butyl-1,2-oxazol-3-yl)-4-hydroxy-1-methylimidazolidin-2-one, 3-[5-chloro-4- (trifluoromethyl)pyridin-2-yl]-4-hydroxy-1-methylimidazolidin-2-one, 4-Hydroxy-1-methoxy-5-methyl-3-[4-(trifluoromethyl)pyridin-2-yl]imidazolidin- 2-one, 6-[(2-Hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-1,5-dimethyl-3-(2-methylphenyl)quinazoline-2,4(1H,3H) - dione, 3-(2,6-dimethylphenyl)-6-[(2-hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-1-methylquinazoline-2,4(1H,3H)-dione , 2-[2-chloro-4-(methylsulfonyl)-3-(morpholin-4-ylmethyl)benzoyl]-3-hydroxycyclohex-2-en-1-one, 1-(2-carboxyethyl)-4-(pyrimidine -2-yl)pyridazin-1-ium salt (with appropriate anions such as chloride, acetate or trifluoroacetate), 1-(2-carboxyethyl)-4-(pyridazin-3-yl)pyridazin-1-ium salt (with appropriate anions such as e.g. chloride, acetate or trifluoroacetate), 4-(pyrimidin-2-yl)-1-(2-sulfoethyl)pyridazin-1-ium salt iums alz (with suitable anions such as chloride, acetate or trifluoroacetate), 4-(pyridazin-3-yl)-1-(2-sulfoethyl)pyridazin-1-ium salt ium salt (with suitable anions such as chloride, acetate or trifluoroacetate) . The invention is intended to be illustrated by the following biological examples, without however being restricted thereto. In Vivo Analysis - Part A Seeds of monocotyledonous and dicotyledonous crops were sown in sandy loam soil in fiberglass or plastic pots, covered with soil or sand and grown in the greenhouse under good growth conditions. The test plants were treated in the early leaf stage (BBCH10 - BBCH13). In order to ensure a uniform water supply before the onset of stress, the planted pots were supplied with water by means of dam irrigation before the substance was applied. The compounds according to the invention, formulated in the form of wettable powders (WP), were sprayed onto the green parts of the plants as an aqueous suspension at a water application rate of the equivalent of 600 l/ha with the addition of 0.2% wetting agent (e.g. Agrotin). The plants were stress treated immediately after the application of the substance. The wood fiber pots were transferred to plastic inserts to prevent them from drying too quickly afterwards. Drought stress was induced by slow drying under the following conditions: "Day": 14 hours illuminated at ~ 26-30°C "Night": 10 hours without illumination at ~ 18-20°C. The duration of the respective stress phases mainly depended on the condition of the stressed control plants. It was terminated (by re-watering and transfer to a greenhouse with good growing conditions) as soon as irreversible damage to the stressed control plants was observed. After the end of the stress phase, a 4-7 day recovery phase followed, during which the plants were again kept in the greenhouse under good growth conditions. The duration of the recovery phase depended mainly on when the test plants had reached a state that allowed visual assessment of potential effects and is therefore variable. When this point in time was reached, the damage intensities were scored visually in comparison to untreated, unstressed controls of the same age. The damage intensity was initially recorded as a percentage. The efficiency of the test compounds was then determined from these values using the following formula:
Figure imgf000439_0001
WG: Efficiency SIs: Damage intensity of the stressed control plants SIt: Damage intensity of the stressed plants treated with test compound The values given in Tables A-1 to A-3 below are mean values from at least one experiment with at least two replicates, the effects of selected compounds of general formula (I) under drought stress are shown on various crops. Table A-1
Figure imgf000440_0001
Figure imgf000441_0001
Tabelle A-2
Figure imgf000441_0002
Tabelle A-3
Figure imgf000442_0001
In vivo-Analysen – Teil B Samen von mono- bzw. dikotylen Kulturpflanzen wurden in Plastiktöpfen in sandigem Lehmboden ausgesät, mit Erde oder Sand abgedeckt und im Gewächshaus unter guten Wachstumsbedingungen angezogen. Die Behandlung der Versuchspflanzen erfolgt im frühen Laubblattstadium (BBCH10 – BBCH13). Zur Gewährleistung einer uniformen Wasserversorgung vor Stressbeginn wurden die bepflanzten Töpfe vor Substanzapplikation durch Anstaubewässerung mit Wasser versorgt. Die erfindungsgemäßen Verbindungen wurden zunächst als benetzbare Pulver (WP) formuliert oder in einem Lösungsmittelgemisch gelöst. Die weitere Verdünnung erfolgte mit Wasser unter Zusatz von 0,2% Netzmittel (z.B. Agrotin). Die fertige Spritzbrühe wurde mit einer Wasseraufwandmenge von umgerechnet 600 l/ha auf die grünen Pflanzenteile gesprüht. Unmittelbar nach Substanzapplikation erfolgte die Stressbehandlung der Pflanzen. Der Trockenstress wurde durch langsames Abtrocknen unter folgenden Bedingungen induziert: „Tag“: 14 Stunden beleuchtet bei ~ 26-30°C „Nacht“: 10 Stunden ohne Beleuchtung bei ~ 18-20°C. Die Dauer der jeweiligen Stressphasen richtete sich hauptsächlich nach dem Zustand der gestressten Kontrollpflanzen. Sie wurde (durch Wiederbewässerung und Transfer in ein Gewächshaus mit guten Wachstumsbedingungen) beendet, sobald irreversible Schäden an den gestressten Kontrollpflanzen zu beobachten waren. Nach Beendigung der Stressphase folgte eine ca.4-7 tägige Erholungsphase, während der die Pflanzen abermals unter guten Wachstumsbedingungen im Gewächshaus gehalten wurden. Die Dauer der Erholungsphase richtete sich hauptsächlich danach, wann die Versuchspflanzen einen Zustand erreicht hatten, der eine visuelle Bonitur potenzieller Effekte ermöglichte, und war daher variabel. Wenn dieser Zeitpunkt erreicht war, wurde das Erscheinungsbild der mit Testsubstanzen behandelten Pflanzen im Vergleich zu den gestressten Kontrollpflanzen nachfolgenden Kategorien erfasst: 0 kein positiver Effekt + leicht positiver Effekt ++ deutlich positiver Effekt +++ stark positiver Effekt Um auszuschließen, dass die beobachteten Effekte von der ggf. fungiziden oder insektiziden Wirkung der Testverbindungen beeinflusst wurden, wurde zudem darauf geachtet, dass die Versuche ohne Pilzinfektion oder Insektenbefall abliefen. Bei den in den untenstehenden Tabellen B-1 und B-2 angegebenen Werten handelt es sich um Mittelwerte der Ergebnisse aus mindestens drei Replikaten. Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) unter Trockenstress gemäß nachstehender Tabellen B-1 und B-2: Tabelle B-1
Figure imgf000444_0001
Tabelle B-2
Figure imgf000444_0002
Figure imgf000441_0001
Table A-2
Figure imgf000441_0002
Table A-3
Figure imgf000442_0001
In Vivo Analysis - Part B Seeds of monocotyledonous and dicotyledonous crops were sown in sandy loam soil in plastic pots, covered with soil or sand and grown in the greenhouse under good growth conditions. The test plants were treated in the early leaf stage (BBCH10 – BBCH13). In order to ensure a uniform water supply before the onset of stress, the planted pots were supplied with water by means of dam irrigation before the substance was applied. The compounds according to the invention were first formulated as wettable powders (WP) or dissolved in a solvent mixture. Further dilution was carried out with water with the addition of 0.2% wetting agent (eg Agrotin). The finished spray mixture was sprayed onto the green parts of the plant with a water application rate of the equivalent of 600 l/ha. The plants were stress treated immediately after the application of the substance. Drought stress was induced by slow drying under the following conditions: "Day": 14 hours illuminated at ~ 26-30°C "Night": 10 hours without illumination at ~ 18-20°C. The duration of the respective stress phases mainly depended on the condition of the stressed control plants. It was terminated (by re-watering and transfer to a greenhouse with good growing conditions) as soon as irreversible damage to the stressed control plants was observed. After the end of the stress phase, a 4-7 day recovery phase followed, during which the plants were again kept in the greenhouse under good growth conditions. The duration of the recovery phase depended mainly on when the test plants had reached a state that allowed visual scoring of potential effects and was therefore variable. When this point in time was reached, the appearance of the plants treated with test substances was recorded in the following categories compared to the stressed control plants: 0 no positive effect + slightly positive effect ++ clearly positive effect +++ strongly positive effect In order to rule out that the observed effects were influenced by the possible fungicidal or insecticidal action of the test compounds, care was also taken to ensure that the tests were carried out without fungal infection or insect infestation. The values reported in Tables B-1 and B-2 below are the mean of the results from at least three replicates. Effects of selected compounds of general formula (I) under drought stress according to Tables B-1 and B-2 below: Table B-1
Figure imgf000444_0001
Table B-2
Figure imgf000444_0002
Figure imgf000445_0001
In den zuvor genannten Tabellen bedeuten: BRSNS = Brassica napus ZEAMX = Zea mays TRZAS = Triticum aestivum
Figure imgf000445_0001
In the tables mentioned above: BRSNS=Brassica napus ZEAMX=Zea mays TRZAS=Triticum aestivum

Claims

Patentansprüche 1. Verwendung substituierter Pyrrolidinone der allgemeinen Formel (I) oder deren Salze
Figure imgf000446_0001
zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress, sowie zur Steigerung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags worin R1 für Wasserstoff, NR30R31, OR32, S(O)mR33, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C2-C8)-Haloalkinyl, (C3-C10)- Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, R32O(O)C- (C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32(O=)C-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32 steht, m für 0, 1, 2 steht, R3 und R4 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C1-C10)- Haloalkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C1-C10)- Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N- (C1-C8)-Alkyl, NR30R31, OR32, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl stehen, R3 und R5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R2 und R7 nicht gleichzeitig H sind und dass R7 für H steht, wenn R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R2 für H steht, wenn R7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht, (
Figure imgf000447_0001
R8, R9, R10, R15, R18, R19, R20 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)- Alkenyl, (C2-C8)-Alkinyl, Aryl-(C1-C8)-Alkyl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl- (C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, S(O)mR33, R32(O=)C-(C1-C8)-Alkyl, C(O=)R32, (C1-C8)-Alkyloxycarbonyl, Aryl-(C1-C8)- Alkyloxycarbonyl stehen, R8 und R9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11, R12, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, OR32 stehen, R16, R17, R21, R22 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stehen, R23, R24 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(O=)R32, (C1-C8)-Alkyloxycarbonyl, Aryl-(C1-C8)- Alkyloxycarbonyl stehen, R25, R28, R29 nabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, Aryl-(C1-C8)-Alkyl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl stehen, R26, R27 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)- Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)- alkyl, (C1-C8)-Alkylthio-(C1-C8)-alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)- Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)- alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C8)-Alkoxycarbonyl, Bis-[(C1-C8)-alkyl]aminocarbonyl- (C1-C8)-alkyl, (C1-C8)-Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl- aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl, Heteroaryl-(C1-C8)- alkoxycarbonyl, (C2-C8)-Alkenyloxycarbonyl, (C2-C8)-Alkinyloxycarbonyl, Heterocyclyl-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)- Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl- (C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)- Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)- haloalkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)- alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkyl, Aryl, Aryl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxy-(C1-C8)- alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)- Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C8)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C8)-alkyl, Hydroxycarbonyl-(C1-C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis- [(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkylcarbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)-alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, Aryloxy-(C1-C8)-alkyl, Heteroaryloxy-(C1-C8)- alkyl, Heterocyclyloxy-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl, (C1-C8)- Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl- (C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl- (C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl steht, R33 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)- Alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino, (C1-C8)- Alkyl-amino, Aryl-(C1-C8)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C8)- alkyl]amino; Heteroaryl-(C1-C8)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C8)-alkyl]amino; Hetercyclyl-(C1-C8)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C8)-alkyl]amino; (C3-C8)-Cycloalkyl-amino, (C3-C8)-Cycloalkyl-[(C1- C8)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht. R34 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)- Alkyl, R30R31N-(C1-C8)-Alkyl, NR30R31, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, S(O)mR33 steht, R35 für Wasserstoff, NR30R31, OR32, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl- (C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)- Alkyl, S(O)mR33, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C- (C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht, R36 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)- Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht, R37 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C2-C8)- Haloalkenyl, (C2-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, Heteroaryloxy-(C1-C8)-Alkyl, Aryloxy-(C1-C8)-Alkyl, Heterocyclyloxy-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C- (C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32(O=)C- (C1-C8)-Alkyl steht und R38 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht. 2. Verwendung gemäß Anspruch 1, wobei in Formel (I) R1 für Wasserstoff, NR30R31, OR32, S(O)mR33, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)- Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C- (C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32 steht, m für 0, 1, 2 steht, R3 und R4 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C1-C10)- Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C1-C6)- Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N- (C1-C6)-Alkyl, NR30R31, OR32, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl stehen, R3 und R5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R2 und R7 nicht gleichzeitig H sind und dass R7 für H steht, wenn R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R2 für H steht, wenn R7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht, (
Figure imgf000452_0001
R8, R9, R10, R15, R18, R19, R20 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)- Alkenyl, (C2-C6)-Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl- (C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)- Alkyloxycarbonyl stehen, R8 und R9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11, R12, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, OR32 stehen, R16, R17, R21, R22 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stehen, R23, R24 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)- Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)- Alkyloxycarbonyl stehen, R25, R28, R29 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl stehen, R26, R27 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)- Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)- Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)- alkyl, (C1-C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)- alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C6)-Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl- (C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl- aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl, Heteroaryl-(C1-C6)- alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)-Alkinyloxycarbonyl, Heterocyclyl-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)- Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy- (C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)- Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C6)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, Hydroxycarbonyl-(C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis- [(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)- alkyl, Heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl, (C1-C6)- Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl- (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl steht, R33 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino, (C1-C6)- Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C6)- alkyl]amino; Heteroaryl-(C1-C6)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C6)-alkyl]amino; Hetercyclyl-(C1-C6)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1- C6)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R34 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, NR30R31, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33 steht, R35 für Wasserstoff, NR30R31, OR32, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl- (C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)- Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C- (C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl steht, R36 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)- Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl steht, R37 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)- Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)- Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, Heteroaryloxy- (C1-C6)-Alkyl, Aryloxy-(C1-C6)-Alkyl, Heterocyclyloxy-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl steht und R38 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht. 3. Verwendung gemäß Anspruch 1, wobei in Formel (I) R1 für Wasserstoff, NR30R31, OR32, S(O)mR33, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)- Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C- (C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32 steht, m für 0, 1, 2 steht, R3 und R4 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Vinyl, 1-Methyleth-1-en-1.yl, prop-2-en-1-yl, Difluormethyl, Trifluormethyl, Cyclopropyl, Cyclobutyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Phenyl, Benzyl, Methoxymethyl, Ethoxymethyl, Methoxyethyl, Ethoxyethyl stehen, R5, R6 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Vinyl, prop-2-en-1-yl, Difluormethyl, Trifluormethyl, Cyclopropyl, Cyclobutyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Phenyl, 4-Fluorphenyl, 3-Fluorphenyl, 2-Fluorphenyl, 4-Chlorphenyl, 3-Chlorphenyl, Claims 1. Use of substituted pyrrolidinones of the general formula (I) or salts thereof
Figure imgf000446_0001
to increase stress tolerance in plants to abiotic stress, and to increase plant growth and/or to increase plant yield wherein R 1 is hydrogen, NR 30 R 31 , OR 32 , S(O)mR 33 , (C 1 -C 8 ) -alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 )haloalkenyl, (C 2 -C 8 ) -Haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )halocycloalkenyl, aryl, aryl-(C 1 -C 8 )alkyl, heteroaryl, heteroaryl-(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 N-(C 1 -C 8 )-alkyl, R 32 O(O)C-(C 1 -C 8 )-alkyl, R 30 R 31 N(O)C-(C 1 -C 8 ) -alkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, R 33 S(O) m -(C 1 -C 8 )alkyl, R 32 (O=)C-( C 1 -C 8 )-alkyl, C(=O)R 32 , C(=O)OR 32 m is 0, 1, 2, R 3 and R 4 are independently hydrogen, (C 1 -C C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 1 -C 10 )haloalkyl, (C 3 -C 10 )cyc loalkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 )alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 8 )alkyl, Heterocyclyl, heterocyclyl-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-alkyl, R 30 R 31 N-(C 1 -C 8 )-alkyl, R 5 , R 6 independently of one another hydrogen, (C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyl, (C 1 -C 10 )-haloalkyl, (C 3 -C 10 )-cycloalkyl, aryl-(C 1 -C 8 )alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl , R 30 R 31 N-(C 1 -C 8 )alkyl, NR 30 R 31 , OR 32 , (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, R 3 and R 5 with the carbon atoms to which they are attached, a fully saturated or partially saturated, optionally interrupted by heteroatoms and form an optionally further substituted 5 to 10-membered monocyclic or bicyclic ring, R 2 represents hydrogen and one of the following groups G-1 to G-2, where an arrow represents a bond to the pyrrolidinone ring in the general formula (I), R 7 stands for hydrogen and one of the following groups G-1 to G-15, where an arrow stands for a bond to the pyrrolidinone ring in the general formula (I), with the proviso that R 2 and R 7 are not H at the same time and that R 7 is H when R 2 is one of the following groups G-1 to G-2, and that R 2 is H when R 7 is one of the following groups G-1 to G-15, (
Figure imgf000447_0001
R 8 , R 9 , R 10 , R 15 , R 18 , R 19 , R 20 independently of one another represent hydrogen, (C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyl, (C 2 -C 8 )-alkynyl, aryl(C 1 -C 8 )alkyl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 ). 8 )-alkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )-alkyl, S(O)m R 33 , R 32 (O=)C-(C 1 -C 8 )-alkyl, C(O=)R 32 , (C 1 -C 8 )-alkyloxycarbonyl, aryl-(C 1 -C 8 )-alkyloxycarbonyl, R 8 and R 9 with the nitrogen atoms to which they are attached form a fully saturated or partially saturated 5 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R 11 , R 12 , R 13 , R 14 are independently hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 10 )haloalkyl, (C 3 - C 10 )cycloalkyl, aryl(C 1 -C 8 )alkyl, aryl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 N-(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, C( =O)R32 , C(= O ) OR32 , C(=O ) NR30 R31 , R32 O(O)C-( C1 -C8 )alkyl, R30 R31 N(O) C-(C 1 -C 8 )-alkyl, OR 32 , R 16 , R 17 , R 21 , R 22 independently represent hydrogen, (C 1 -C 8 )-alkyl, (C 2 -C 8 )- Alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 10 )haloalkyl, (C 3 -C 10 )cycloalkyl, aryl(C 1 -C 8 )alkyl, aryl, hetero aryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 N-(C C1 -C8 )alkyl, ( C3 -C10 ) cycloalkyl- (C1 -C8 )alkyl, C(=O) R32 , C(=O) OR32 , C(=O) NR 30 R 31 stand, R 23 , R 24 independently of one another are hydrogen, (C 1 -C 8 )-alkyl, (C 1 -C 10 )-haloalkyl, (C 3 -C 10 )-cycloalkyl, aryl-(C 1 -C 8 )alkyl, aryl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl , R 30 R 31 N-(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, C(O=)R 32 , (C 1 -C 8 )-alkyloxycarbonyl, aryl-(C 1 -C 8 )-alkyloxycarbonyl, R 25 , R 28 , R 29 independently of one another are hydrogen, (C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyl , (C 2 -C 8 )- alkynyl, aryl-(C 1 -C 8 )-alkyl, heteroaryl-(C 1 -C 8 )-alkyl, heterocyclyl-(C 1 -C 8 )-alkyl, R 32 O -(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, R 32 (O=)C-(C 1 -C 8 )alkyl, R 26 , R 27 independently of one another er for hydrogen, (C 1 -C 8 )-alkyl, (C 1 -C 10 )-haloalkyl, (C 3 -C 10 )-cycloalkyl, (C 3 -C 10 )-cycloalkyl-(C 1 -C 8 ). )-alkyl, aryl(C 1 -C 8 )alkyl, aryl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, R 30 and R 31 are independently hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )cyanoalkyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 )haloalkenyl, (C 3 -C 8 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )halocycloalkenyl, (C 1 -C 8 )alkoxy-(C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkoxy-(C 1 -C 8 )alkyl, (C 1 -C 8 )alkylthio-(C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkylthio-(C 1 -C 8 )alkyl, (C 1 -C8 )- Alkoxy(C 1 -C 8 )haloalkyl, aryl, aryl(C 1 -C 8 )alkyl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl (C 1 -C 8 )alkyl, (C 4 -C 10 )cycloalkenyl-(C 1 -C 8 )alkyl, COR 32 , SO 2 R 33 , heterocyclyl, (C 1 -C 8 )alkoxycarbonyl, Bis[(C 1 -C 8 )alkyl]aminocarbonyl-(C 1 -C 8 )alkyl, (C 1 -C 8 )alkylaminocarbonyl-(C 1 -C 8 )alkyl, aryl-( C 1 -C 8 )alkylaminocarbonyl-(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 ) alkoxycarbonyl , heteroaryl-(C 1 -C 8 )alkoxycarbonyl, (C 2 -C 8 )alkenyloxycarbonyl, (C 2 -C 8 )alkynyloxycarbonyl, heterocyclyl(C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 )alkyl, (C 2 -C 8 )- alkenyloxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkynyloxycarbonyl-(C 1 -C 8 )-alkyl, aryl-(C 1 -C 8 )-alkoxycarbonyl-( C 1 -C 8 )alkyl, heteroaryl-(C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 )alkyl, heterocyclyl-(C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 ) -alkyl, or R 30 and R 31 with the nitrogen atom to which they are attached, a fully sat saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring, R 32 is hydrogen, (C 1 -C 8 ) alkyl, (C 2 -C 8 ) alkenyl, (C C 2 -C 8 )alkynyl, (C 1 -C 8 )cyanoalkyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 )haloalkenyl, (C 3 -C 8 )haloalkynyl, (C C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )halocycloalkenyl, (C 1 -C 8 )alkoxy(C C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkoxy(C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxy(C 1 -C 8 )haloalkyl, (C C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl, (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy (C C 1 -C 8 )alkoxy-(C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxy-(C 1 -C 8 )alkoxy-(C 1 -C 8 )alkoxy-(C C 1 -C 8 )alkoxy(C 1 -C 8 )alkyl, aryl, aryl(C 1 -C 8 )alkyl, aryl(C 1 -C 8 )alkoxy(C 1 -C 8 ). )-alkyl, heteroaryl, heteroaryl-(C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl-(C 1 -C 8 )alkyl, (C 4 -C 10 ). )-cycloalkenyl(C 1 -C 8 )alkyl, bis[(C 1 -C 8 )alkyl]aminocarbonyl(C 1 -C 8 )alkyl, (C 1 -C 8 )alkylaminocarbonyl -(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 )alkylaminocarbonyl-(C 1 -C 8 )alkyl, bis[(C 1 -C 8 )alkyl]amino- (C 2 -C 6 )alkyl, (C 1 -C 8 )alkylamino-(C 2 -C 6 )alkyl, aryl-(C 1 -C 8 )alkylamino- (C 2 - C 6 )alkyl, R 33 (O) m S-(C 1 -C 8 )alkyl, hydroxycarbonyl-(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )alkyl, Tris[(C 1 -C 8 )alkyl]silyl(C 1 -C 8 )alkyl, bis[(C 1 -C 8 )alkyl](aryl)silyl(C 1 -C 8 )- alkyl, [(C 1 -C 8 )alkyl]bis(aryl)silyl(C 1 -C 8 )alkyl, (C 1 -C 8 )alkylcarbonyloxy(C 1 -C 8 )alkyl , (C 3 -C 8 )cycloalkylcarbonyloxy-(C 1 -C 8 )alkyl, arylcarbonyloxy-(C 1 -C 8 )alkyl, heteroarylcarbonyloxy-(C 1 -C 8 )alkyl, heterocyclylcarbonyloxy-(C 1 -C 8 )alkyl, aryloxy-(C 1 -C 8 )alkyl, heteroaryloxy-(C 1 -C 8 )alkyl, heterocyclyloxy-(C 1 -C 8 )alkyl, (C 1 -C 8 ) -alkoxycarbonyl, (C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 )alkyl , (C 2 -C 8 )alkenyloxycarbonyl-(C 1 -C 8 )alkyl, (C 2 -C 8 )alkynyloxycarbonyl-(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 ) -alkoxycarbonyl- (C 1 -C 8 )alkyl, heteroaryl-(C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 )alkyl, heterocyclyl-(C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 ). )-alkyl, R 33 is hydrogen, (C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyl, (C 2 -C 8 )-alkynyl, (C 1 -C 8 )-cyanoalkyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 )haloalkenyl, (C 3 -C 8 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )halocycloalkenyl, (C 1 -C 8 )alkoxy-(C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxy (C 1 -C 8 )haloalkyl, aryl, aryl(C 1 -C 8 )alkyl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl(C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl-(C 1 -C 8 )alkyl, (C 4 -C 10 )cycloalkenyl-(C 1 -C 8 )alkyl, bis[(C 1 -C 8 ) -alkyl]amino, (C 1 -C 8 )-alkylamino, aryl-(C 1 -C 8 )-amino, aryl-(C 1 -C 6 )-alkylamino, aryl-[(C 1 - C 8 alkyl]amino; heteroaryl(C 1 -C 8 )amino, heteroaryl(C 1 -C 6 )alkylamino, heteroaryl[(C 1 -C 8 )alkyl]amino; heterocyclyl(C 1 -C 8 )amino, heterocyclyl(C 1 -C 6 )alkylamino, heterocyclyl[(C 1 -C 8 )alkyl]amino; (C 3 -C 8 )cycloalkylamino, (C 3 -C 8 )cycloalkyl[(C 1 -C 8 )alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl. R 34 is hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, aryl-(C 1 -C 8 )alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 8 ) -alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-alkyl, R 30 R 31 N-(C 1 -C 8 )-alkyl, NR 30 R 31 , (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, S(O) m R 33 , R 35 is hydrogen, NR 30 R 31 , OR 32 , (C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyl, (C 2 -C 8 )-alkynyl, aryl, aryl-(C 1 -C 8 )-alkyl, heteroaryl, heteroaryl-(C 1 -C 8 )- Alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-alkyl, (C 3 -C 10 )-cycloalkyl, (C 3 -C 10 )-cycloalkyl- (C 1 -C 8 )-alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 8 )-alkyl, R 32 O(O)C-(C 1 -C 8 )-alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-alkyl, R 33 S(O) m -(C 1 -C 8 )-alkyl, R 32 O-(C 1 - C 8 )alkyl, R 30 R 31 is N-(C 1 -C 8 )alkyl, R 36 is hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C C 2 -C 8 )alkynyl, aryl, aryl(C 1 -C 8 )alkyl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocy clyl, heterocyclyl(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )cycloalkyl(C 1 -C 8 )alkyl, R 32 (O=) C-(C 1 -C 8 )alkyl, R 32 O(O)C-(C 1 -C 8 )alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )alkyl, R 33 S(O)m-(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 N-(C 1 -C 8 )alkyl, R 37 for (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 )- Haloalkenyl, (C 2 -C 8 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )- halocycloalkenyl, aryl, aryl(C 1 -C 8 )alkyl, Heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, heteroaryloxy(C 1 -C 8 )alkyl, aryloxy(C 1 -C 8 )- Alkyl, heterocyclyloxy-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-alkyl, R 30 R 31 N-(C 1 -C 8 )-alkyl, R 32 O(O) C-(C 1 -C 8 )alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )- alkyl, R 33 is S(O) m -(C 1 -C 8 )-alkyl, R 32 is (O=)C-(C 1 -C 8 )-alkyl and R 38 is (C 1 -C 8 )- Alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, aryl, aryl-(C 1 -C 8 )alkyl, heteroaryl, heteroaryl-(C 1 -C 8 )alkyl, Heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )cycloalkyl(C 1 -C 8 )alkyl, R 32 (O=) C-(C 1 -C 8 )alkyl, R 32 O(O)C-(C 1 -C 8 )alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )alkyl, R 33 is S(O)m-(C 1 -C 8 )alkyl, R 32 is O-(C 1 -C 8 )alkyl, R 30 R 31 is N-(C 1 -C 8 )alkyl. 2. Use according to claim 1, wherein in formula (I) R 1 is hydrogen, NR 30 R 31 , OR 32 , S(O)mR 33 , (C 1 -C 6 )-alkyl, (C 2 -C 6 ) -alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloalkenyl, (C 2 -C 6 )haloalkynyl, (C 3 -C 6 ) - cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 )halocycloalkenyl, aryl, aryl-(C 1 -C 6 )alkyl, heteroaryl, heteroaryl -(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl, R 30 R 31 N-(C 1 -C 6 )-alkyl, R 32 O(O)C-(C 1 -C 6 )-alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-alkyl, (C 3 -C 10 ) -cycloalkyl-(C 1 -C 6 )alkyl, R 33 S(O)m-(C 1 -C 6 )alkyl, R 32 (O=)C-(C 1 -C 6 )alkyl, C (=O)R 32 , C(=O)OR 32 m is 0, 1, 2, R 3 and R 4 are independently hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 1 -C 10 )haloalkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, aryl-(C 1 -C 6 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, Heterocyclyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-alkyl, R 30 R 31 N-(C 1 -C 6 )-alkyl, R 5 , R 6 independently of one another hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 1 -C 6 )-haloalkyl, (C 3 -C 6 )-cycloalkyl, aryl-(C 1 -C 6 )alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl , R 30 R 31 N-(C 1 -C 6 )-alkyl, NR 30 R 31 , OR 32 , (C 3 -C 6 )-cycloalkyl-(C 1 -C 6 )-alkyl, R 3 and R 5 with the carbon atoms to which they are attached form a fully saturated or partially saturated 5 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R 2 is hydrogen and one of the following groups G -1 to G-2, with an arrow representing a bond to the pyrrolidinone ring in the general formula (I), R 7 represents hydrogen and one of the following groups G-1 to G-15, with an arrow representing a bond to pyrrolidinone ring in the general formula (I), with the proviso that R 2 and R 7 are not H at the same time and that R 7 is H when R 2 is one of the following groups G-1 to G-2, and that R 2 is H if R 7 is one of the following groups G-1 to G-15, (
Figure imgf000452_0001
R 8 , R 9 , R 10 , R 15 , R 18 , R 19 , R 20 independently of one another represent hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, aryl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl, heterocyclyl(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 ). 6 )-alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )-alkyl, S(O)m R 33 , R 32 (O=)C-(C 1 -C 6 )alkyl, C(O=)R 32 , (C 1 -C 6 )alkyloxycarbonyl, aryl-(C 1 -C 6 )alkyloxycarbonyl, R 8 and R 9 with the nitrogen atoms to which they are attached form a fully saturated or partially saturated 5 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R 11 , R 12 , R 13 , R 14 independently of one another hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )haloalkyl, (C 3 -C 6 )-cycloalkyl, aryl(C 1 -C 6 )alkyl, aryl, heteroaryl, heteroaryl(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 6 )alkyl, R 32 O -(C 1 -C 6 )alkyl, R 30 R 31 N-(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, C(= O)R32 , C(= O ) OR32 , C(=O ) NR30 R31 , R32 O(O)C-( C1 -C6 )alkyl, R30 R31 N(O)C -(C 1 -C 6 )alkyl, OR 32 , R 16 , R 17 , R 21 , R 22 independently represent hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alk enyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )haloalkyl, (C 3 -C 6 )cycloalkyl, aryl-(C 1 -C 6 )alkyl, aryl, heteroaryl, heteroaryl- (C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl, R 30 R 31 N-(C 1 -C 6 ). )-alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )-alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 23 , R 24 are independently hydrogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-haloalkyl, (C 3 -C 6 )-cycloalkyl, aryl-(C 1 -C 6 ) -alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl, R 30 R 31 N-(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, C(O=)R 32 , (C 1 -C 6 )alkyloxycarbonyl , aryl-(C 1 -C 6 )-alkyloxycarbonyl, R 25 , R 28 , R 29 independently represent hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )- alkynyl, aryl-(C 1 -C 6 )-alkyl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C6 )alkyl, ( C3 -C 6 )-cycloalkyl-(C 1 -C 6 )-alkyl, R 32 (O=)C-(C 1 -C 6 )-alkyl, R 26 , R 27 are independently hydrogen, (C 1 - C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, aryl-(C C 1 -C 6 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 30 and R 31 independently represent hydrogen, ( C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )haloalkyl, ( C 2 -C 6 )haloalkenyl, (C 3 -C 6 )haloalkynyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 )halocycloalkenyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy (C 1 -C 6 )haloalkyl, aryl, aryl-(C 1 -C 6 )alkyl, heteroaryl, heteroaryl-(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl-(C C 1 -C 6 )alkyl, (C 4 -C 6 )cycloalkenyl-(C 1 -C 6 )alkyl, COR 32 , SO 2 R 33 , heterocyclyl, (C 1 -C 6 )alkoxycarbonyl, bis- [(C 1 -C 6 )alkyl]aminocarbonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylaminocarbonyl-(C 1 -C 6 )alkyl, aryl-(C 1 -C 6 )alkylaminocarbonyl-(C 1 -C 6 )alkyl, aryl-(C 1 -C 6 ) alkoxycarbonyl , heteroaryl-(C 1 -C 6 )alkoxycarbonyl, (C 2 -C 6 ) -alkenyloxycarbonyl, (C 2 -C 6 )alkynyloxycarbonyl, heterocyclyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkyl, (C 2 -C 6 )- alkenyloxycarbonyl-(C 1 -C 6 )alkyl, (C 2 -C 6 )alkynyloxycarbonyl-(C 1 -C 6 )alkyl, aryl-(C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkyl, hetero aryl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, heterocyclyl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, or R 30 and R 31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R 32 is hydrogen, (C 1 -C 6 )-alkyl , (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloalkenyl , (C 3 -C 6 )haloalkynyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 )halocycloalkenyl , (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy -(C 1 -C 6 )haloalkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy -(C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy -(C 1 -C 6 )-alkoxy- (C C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, aryl, aryl(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkoxy(C 1 -C 6 ). )-alkyl, heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-cycloalkyl-(C 1 -C 6 )-alkyl, (C 4 -C 6 )-cycloalkenyl-(C C 1 -C 6 )alkyl, bis[(C 1 -C 6 )alkyl]aminocarbonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylaminocarbonyl-(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkylaminocarbonyl(C 1 -C 6 )alkyl, bis[(C 1 -C 6 )alkyl]amino(C 2 -C 6 ). )-alkyl, (C 1 -C 6 )-alkylamino-(C 2 -C 6 )-alkyl, aryl-(C 1 -C 6 ) -alkyl - amino- (C 2 -C 6 )-alkyl, R 33 (O) m S-(C 1 -C 6 )alkyl, hydroxycarbonyl-(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )alkyl, tris[(C 1 -C 6 )alkyl]silyl(C 1 -C 6 )alkyl, bis[(C 1 -C 6 )alkyl](aryl)silyl(C 1 -C 6 )alkyl, [(C 1 -C 6 )alkyl]bis(aryl)silyl(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylcarbonyloxy-(C 1 -C 6 )alkyl, (C 3 -C 6 )-cycloalkylcarbonyloxy(C 1 -C 6 )alkyl, arylcarbonyloxy(C 1 -C 6 )alkyl, heteroarylcarbonyloxy(C 1 -C 6 )alkyl, heterocyc lylcarbonyloxy(C 1 -C 6 )alkyl, aryloxy(C 1 -C 6 )alkyl, heteroaryloxy(C 1 -C 6 )alkyl, heterocyclyloxy(C 1 -C 6 )alkyl, (C C 1 -C 6 )alkoxycarbonyl, (C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyloxycarbonyl-(C 1 -C 6 )alkyl, (C 2 -C 6 )alkynyloxycarbonyl(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 ). )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, heterocyclyl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl , R 33 represents hydrogen, (C 1 -C 6 )- alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )- Haloalkenyl, (C 3 -C 6 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 )- Halocycloalkenyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )haloalkyl, aryl, aryl(C 1 - C 6 )alkyl, heteroaryl, heteroaryl-(C 1 -C 6 )alkyl, heterocyclyl-(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )- alkyl, (C 4 -C 10 )cycloalkenyl(C 1 -C 6 )alkyl, bis[(C 1 -C 6 )alkyl]amino, (C 1 -C 6 )alkylamino, aryl -(C 1 -C 6 )amino, aryl(C 1 -C 6 )alkylamino, aryl[(C 1 -C 6 )alkyl]amino; heteroaryl(C 1 -C 6 )amino, heteroaryl(C 1 -C 6 )alkylamino, heteroaryl[(C 1 -C 6 )alkyl]amino; heterocyclyl(C 1 -C 6 )amino, heterocyclyl(C 1 -C 6 )alkylamino, heterocyclyl[(C 1 -C 6 )alkyl]amino; (C 3 -C 6 )cycloalkylamino, (C 3 -C 6 )cycloalkyl[(C 1 -C 6 )alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R 34 is hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, aryl-(C 1 -C 6 )alkyl, aryl, heteroaryl, heteroaryl-(C C 1 -C 6 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )- alkyl, R 30 R 31 N-(C 1 -C 6 )- alkyl, NR 30 R 31 , (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, S(O)mR 33 is R 35 is hydrogen, NR 30 R 31 , OR 32 , (C C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, aryl, aryl-(C 1 -C 6 )alkyl, heteroaryl, heteroaryl-(C 1 - C 6 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 ). )-cycloalkyl-(C 1 -C 6 )-alkyl, S(O)m R 33 , R 32 (O=)C-(C 1 -C 6 )-alkyl, R 32 O(O)C-(C 1 -C 6 )-alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-alkyl, R 33 S(O)m-(C 1 -C 6 )-alkyl, R 32 O-( C 1 -C 6 )alkyl, R 30 R 31 is N-(C 1 -C 6 )alkyl, R 36 is hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl , (C 2 -C 6 )alkynyl, aryl, aryl(C 1 -C 6 )alkyl, heteroaryl, heteroaryl(C 1 -C 6 )alk yl, heterocyclyl, heterocyclyl-(C 1 -C 6 )alkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, R 32 (O =)C-(C 1 -C 6 )alkyl, R 32 O(O)C-(C 1 -C 6 )alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )- alkyl, R 33 is S(O)m-(C 1 -C 6 )alkyl, R 32 is O-(C 1 -C 6 )alkyl, R 30 R 31 is N-(C 1 -C 6 )alkyl , R 37 is (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 ). )- haloalkenyl, (C 2 -C 6 )haloalkynyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )- Cycloalkenyl, (C 4 -C 6 )halocycloalkenyl, aryl, aryl(C 1 -C 6 )alkyl, heteroaryl, heteroaryl(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 6 ). )-alkyl, heteroaryloxy-(C 1 -C 6 )-alkyl, aryloxy-(C 1 -C 6 )-alkyl, heterocyclyloxy-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 ). )-alkyl, R 30 R 31 N-(C 1 -C 6 )-alkyl, R 32 O(O)C-(C 1 -C 6 )-alkyl, R 30 R 31 N(O)C-(C C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, R 33 S(O) m -(C 1 -C 6 )alkyl, R 32 (O =)C-(C 1 -C 6 )alkyl and R 38 represents (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, aryl, aryl(C 1 -C 8 )alkyl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )cycloalkyl-(C 1 -C 8 )alkyl, R 32 (O=)C-(C 1 -C 8 )alkyl, R 32 O(O)C-(C 1 - C 8 )alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )alkyl, R 33 S(O)m-(C 1 -C 8 )alkyl, R 32 O-(C C 1 -C 8 )alkyl, R 30 R 31 is N-(C 1 -C 8 )alkyl. 3. Use according to claim 1, wherein in formula (I) R 1 is hydrogen, NR 30 R 31 , OR 32 , S(O)mR 33 , (C 1 -C 6 )-alkyl, (C 2 -C 6 ) -alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloalkenyl, (C 2 -C 6 )haloalkynyl, (C 3 -C 6 ) - cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 )halocycloalkenyl, aryl, aryl-(C 1 -C 6 )alkyl, heteroaryl, heteroaryl -(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl, R 30 R 31 N-(C 1 -C 6 )-alkyl, R 32 O(O)C-(C 1 -C 6 )-alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-alkyl, (C 3 -C 10 ) -cycloalkyl-(C 1 -C 6 )alkyl, R 33 S(O)m-(C 1 -C 6 )alkyl, R 32 (O=)C-(C 1 -C 6 )alkyl, C (=O)R 32 , C(=O)OR 32 m is 0, 1, 2, R 3 and R 4 are independently hydrogen, methyl, ethyl, prop-1-yl, 1-methyleth-1 -yl, vinyl, 1-methyleth-1-en-1.yl, prop-2-en-1-yl, difluoromethyl, trifluoromethyl, cyclopropyl, cyclobutyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, C cyclohexylmethyl, phenyl, benzyl, methoxymethyl, ethoxymethyl, methoxyethyl, ethoxyethyl, R 5 , R 6 independently of one another are hydrogen, methyl, ethyl, prop-1-yl, 1-methyleth-1-yl, vinyl, prop-2-ene -1-yl, difluoromethyl, trifluoromethyl, cyclopropyl, cyclobutyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, phenyl, 4-fluorophenyl, 3-fluorophenyl, 2-fluorophenyl, 4-chlorophenyl, 3-chlorophenyl,
2- Chlorphenyl, Benzyl, 4-Fluorbenzyl, 2-chlorophenyl, benzyl, 4-fluorobenzyl,
3-Fluorbenzyl, 2-Fluorbenzyl, Pyridin-2-ylmethyl, Pyridin-3-ylmethyl, Pyridin-4-ylmethyl, Methoxymethyl, Ethoxymethyl, Methoxyethyl, Ethoxyethyl, Heterocyclyl, Hydroxy, Methoxy, Ethoxy, Methylcarbonyloxy, Ethylcarbonyloxy, 1-Methyleth-1-ylcarbonyloxy, 1,1-Dimethyleth-1-ylcarbonyloxy stehen, R3 und R5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R2 und R7 nicht gleichzeitig H sind und dass R7 für H steht, wenn R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R2 für H steht, wenn R7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht, 3-fluorobenzyl, 2-fluorobenzyl, pyridin-2-ylmethyl, pyridin-3-ylmethyl, pyridin-4-ylmethyl, methoxymethyl, ethoxymethyl, methoxyethyl, ethoxyethyl, heterocyclyl, hydroxy, methoxy, ethoxy, methylcarbonyloxy, ethylcarbonyloxy, 1-methyleth- 1-ylcarbonyloxy, 1,1-dimethyleth-1-ylcarbonyloxy, R 3 and R 5 with the carbon atoms to which they are attached are a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 5 to 10-membered monocyclic or form a bicyclic ring, R 2 represents hydrogen and one of the following groups G-1 to G-2, where an arrow represents a bond to the pyrrolidinone ring in the general formula (I), R 7 represents hydrogen and one of the following groups G -1 to G-15, where an arrow represents a bond to the pyrrolidinone ring in the general formula (I), with the proviso that R 2 and R 7 are not H at the same time and that R 7 represents H when R 2 for a d he following groups G-1 to G-2 stands, and that R 2 stands for H if R 7 stands for one of the following groups G-1 to G-15,
Figure imgf000458_0001
R8, R9, R10, R15, R18, R19, R20 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)- Alkenyl, (C2-C6)-Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl- (C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)- Alkyloxycarbonyl stehen, R8 und R9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11, R12, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, OR32 stehen, R16, R17, R21, R22 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stehen, R23, R24 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)- Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)- Alkyloxycarbonyl stehen, R25, R28, R29 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl stehen, R26, R27 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)- Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)- Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)- alkyl, (C1-C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)- alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C6)-Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl- (C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl- aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl, Heteroaryl-(C1-C6)- alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)-Alkinyloxycarbonyl, Heterocyclyl-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)- Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy- (C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)- Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C6)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, Hydroxycarbonyl-(C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis- [(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)- alkyl, Heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl, (C1-C6)- Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl- (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl steht, R33 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino, (C1-C6)- Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C6)- alkyl]amino; Heteroaryl-(C1-C6)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C6)-alkyl]amino; Hetercyclyl-(C1-C6)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1- C6)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R34 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, NR30R31, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33 steht, R35 für Wasserstoff, NR30R31, OR32, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl- (C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)- Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C- (C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl steht, R36 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)- Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl steht, R37 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)- Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)- Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, Heteroaryloxy- (C1-C6)-Alkyl, Aryloxy-(C1-C6)-Alkyl, Heterocyclyloxy-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl steht und R38 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht.
Figure imgf000458_0001
R 8 , R 9 , R 10 , R 15 , R 18 , R 19 , R 20 independently of one another represent hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, aryl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl, heterocyclyl(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 ). 6 )-alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )-alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 6 )-alkyl , C(O=)R 32 , (C 1 -C 6 )alkyloxycarbonyl, aryl-(C 1 -C 6 )alkyloxycarbonyl, R 8 and R 9 with the nitrogen atoms to which they are attached a fully saturated one or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 5 to 10-membered monocyclic or bicyclic ring, R 11 , R 12 , R 13 , R 14 independently of one another represent hydrogen, (C 1 -C 6 )-alkyl, (C C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )haloalkyl, (C 3 -C 6 )cycloalkyl, aryl(C 1 -C 6 )alkyl, Aryl, heteroaryl, heteroaryl(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 6 )alkyl, R 32 O -(C 1 -C 6 )alkyl, R 30 R 31 N-(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, C(= O)R32 , C(= O ) OR32 , C(=O ) NR30 R31 , R32 O(O)C-( C1 -C6 )alkyl, R30 R31 N(O)C -(C 1 -C 6 )alkyl, OR 32 , R 16 , R 17 , R 21 , R 22 independently represent hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl , (C 2 -C 6 )alkynyl, (C 1 -C 6 )haloalkyl, (C 3 -C 6 )cycloalkyl, aryl-(C 1 -C 6 )alkyl, aryl, Heteroaryl, heteroaryl(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl, R 30 R 31 N-(C C1 -C6 )alkyl, ( C3 -C6 ) cycloalkyl- (C1 -C6 )alkyl, C(=O) R32 , C(=O) OR32 , C(=O) NR 30 R 31 stand, R 23 , R 24 independently of one another are hydrogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-haloalkyl, (C 3 -C 6 )-cycloalkyl, aryl-(C 1 -C 6 )alkyl, aryl, heteroaryl, heteroaryl(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl , R 30 R 31 N-(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, C(O=)R 32 , (C 1 -C 6 )-alkyloxycarbonyl, aryl-(C 1 -C 6 )-alkyloxycarbonyl, R 25 , R 28 , R 29 independently represent hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl , (C 2 -C 6 )- alkynyl, aryl-(C 1 -C 6 )-alkyl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O -(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, R 32 is (O=)C-(C 1 -C 6 )alkyl, R 26 , R 27 independently of each other Hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 ) )-alkyl, aryl(C 1 -C 6 )alkyl, aryl, heteroaryl, heteroaryl(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 6 )alkyl, R 30 and R 31 are independently hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloalkenyl, (C 3 -C 6 )haloalkynyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 )halocycloalkenyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkoxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )-Alkoxy(C 1 -C 6 )haloalkyl, aryl, aryl(C 1 -C 6 )alkyl, heteroaryl, heteroaryl(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl(C 1 -C 6 )alkyl, (C 4 -C 6 )cycloalkenyl(C 1 -C 6 )alkyl, COR 32 , SO2R 33 , heterocyclyl, (C 1 -C 6 ) -Alkoxyca aryl, bis[(C 1 -C 6 )alkyl]aminocarbonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylaminocarbonyl-(C 1 -C 6 )alkyl, aryl -(C 1 -C 6 )alkylaminocarbonyl-(C 1 -C 6 )alkyl, aryl-(C 1 -C 6 ) alkoxycarbonyl , heteroaryl-(C 1 -C 6 )alkoxycarbonyl, (C 2 -C 6 )alkenyloxycarbonyl, (C 2 -C 6 )alkynyloxycarbonyl, heterocyclyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkyl, ( C 2 -C 6 alkenyloxycarbonyl(C 1 -C 6 )alkyl, (C 2 -C 6 )alkynyloxycarbonyl(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkoxycarbonyl -(C 1 -C 6 )alkyl, heteroaryl-(C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkyl, heterocyclyl-(C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 ). 6 )-alkyl , or R 30 and R 31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R 32 is hydrogen, (C 1 -C C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 ) haloalkenyl , ( C3 -C6 ) haloalkynyl , ( C3 -C6 )cycloalkyl, (C3 -C6 ) halocycloalkyl , (C4 -C6 )cycloalkenyl, (C4 -C 6 )halocycloalkenyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )haloalkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxy-(C 1 -C 6 ) 6 )-alkoxy(C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, aryl, aryl(C 1 -C 6 )alkyl, aryl -(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, heteroaryl, H eteroaryl(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl(C 1 -C 6 )alkyl, (C 4 -C 6 )cycloalkenyl(C 1 -C 6 )- alkyl, bis[(C 1 -C 6 )alkyl]aminocarbonyl(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylaminocarbonyl(C 1 -C 6 )alkyl, aryl -(C 1 -C 6 )alkylaminocarbonyl-(C 1 -C 6 )alkyl, bis[(C 1 -C 6 )alkyl]amino-(C 2 -C 6 )alkyl, (C C 1 -C 6 )alkylamino-(C 2 -C 6 )alkyl, aryl-(C 1 -C 6 )alkylamino-(C 2 -C 6 )alkyl, R 33 (O)m S -(C 1 -C 6 )alkyl, hydroxycarbonyl-(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )alkyl, tris[(C 1 -C 6 )alkyl] silyl(C 1 -C 6 )alkyl, bis[(C 1 -C 6 )alkyl](aryl)silyl(C 1 -C 6 )alkyl, [(C 1 -C 6 )alkyl] -bis-(aryl)silyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylcarbonyloxy-(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkylcarbonyloxy-(C C 1 -C 6 )alkyl, arylcarbonyloxy-(C 1 -C 6 )alkyl, heteroarylcarbonyloxy-(C 1 -C 6 )alkyl, heterocyclylcarbonyloxy-(C 1 -C 6 )alkyl, aryloxy-(C 1 - C 6 alkyl, heteroaryloxy(C 1 -C 6 )alkyl, heterocyclyloxy(C 1 -C 6 )al alkyl, (C 1 -C 6 )alkoxycarbonyl, (C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyloxycarbonyl-(C 1 -C 6 )- alkyl, (C 2 -C 6 )alkynyloxycarbonyl-(C 1 -C 6 )alkyl, aryl-(C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkyl, heteroaryl-(C 1 - C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, heterocyclyl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, R 33 represents hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 ). )haloalkenyl, (C 3 -C 6 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 ). )halocycloalkenyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )haloalkyl, aryl, aryl(C C 1 -C 6 )alkyl, heteroaryl, heteroaryl(C 1 -C 6 )alkyl, heterocyclyl(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl(C 1 -C 6 ). )-alkyl, (C 4 -C 10 )cycloalkenyl-(C 1 -C 6 )-alkyl, bis[(C 1 -C 6 )-alkyl]amino, (C 1 -C 6 )-alkyl-amino , aryl(C 1 -C 6 )amino, Ar yl(C 1 -C 6 )alkylamino, aryl[(C 1 -C 6 )alkyl]amino; heteroaryl(C 1 -C 6 )amino, heteroaryl(C 1 -C 6 )alkylamino, heteroaryl[(C 1 -C 6 )alkyl]amino; heterocyclyl(C 1 -C 6 )amino, heterocyclyl(C 1 -C 6 )alkylamino, heterocyclyl[(C 1 -C 6 )alkyl]amino; (C 3 -C 6 )cycloalkylamino, (C 3 -C 6 )cycloalkyl[(C 1 -C 6 )alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R 34 is hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, aryl-(C 1 -C 6 )alkyl, aryl, heteroaryl, heteroaryl-(C C 1 -C 6 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )- alkyl, R 30 R 31 N-(C 1 -C 6 )- alkyl, NR 30 R 31 , (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, S(O) m R 33 , R 35 is hydrogen, NR 30 R 31 , OR 32 , ( C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, aryl, aryl-(C 1 -C 6 )alkyl, heteroaryl, heteroaryl-(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )-cycloalkyl-(C 1 -C 6 )-alkyl, S(O)m R 33 , R 32 (O=)C-(C 1 -C 6 )-alkyl, R 32 O(O)C-(C C 1 -C 6 )-alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-alkyl, R 33 S(O)m-(C 1 -C 6 )-alkyl, R 32 O- (C 1 -C 6 )-alkyl, R 30 R 31 is N-(C 1 -C 6 )-alkyl, R 36 is hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )- Alkenyl, (C 2 -C 6 )alkynyl, aryl, aryl-(C 1 -C 6 )alkyl, heteroaryl, heteroaryl-(C 1 -C 6 )-A alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )alkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, R 32 (O =)C-(C 1 -C 6 )alkyl, R 32 O(O)C-(C 1 -C 6 )alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )- alkyl, R 33 is S(O)m-(C 1 -C 6 )alkyl, R 32 is O-(C 1 -C 6 )alkyl, R 30 R 31 is N-(C 1 -C 6 )alkyl , R 37 is (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 ). )-haloalkenyl, (C 2 -C 6 )haloalkynyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 ). )-halocycloalkenyl, aryl, aryl(C 1 -C 6 )alkyl, heteroaryl, heteroaryl(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 6 )alkyl, heteroaryloxy(C C 1 -C 6 )alkyl, aryloxy(C 1 -C 6 )alkyl, heterocyclyloxy(C 1 -C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl, R 30 R 31 N-(C 1 -C 6 )alkyl, R 32 O(O)C-(C 1 -C 6 )alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, R 33 S(O) m -(C 1 -C 6 )alkyl, R 32 (O=)C-(C 1 - C 6 ) alkyl and R 38 is (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, aryl, aryl(C 1 -C 8 )alkyl, heteroaryl , heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )cycloalkyl(C 1 -C 8 )alkyl, R 32 (O=)C-(C 1 -C 8 )alkyl, R 32 O(O)C-(C 1 -C 8 )alkyl, R 30 R 31 N(O )C-(C 1 -C 8 )alkyl, R 33 S(O) m -(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 N -(C 1 -C 8 )alkyl.
4. Behandlung von Pflanzen, umfassend die Applikation einer zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksamen, nicht- toxischen Menge einer oder mehrerer der Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3. 4. Treatment of plants, comprising the application of a non-toxic amount effective to increase the resistance of plants to abiotic stress factors of one or more of the compounds of the formula (I) or their salts according to any one of claims 1 to 3.
5. Behandlung gemäß Anspruch 4, wobei die abiotischen Stressbedingungen einer oder mehrerer Bedingungen ausgewählt aus der Gruppe bestehend aus Dürre, Kältestress, Hitzestress, Trockenstress, osmotischem Stress, Staunässe, erhöhtem Bodensalzgehalt, erhöhtem Ausgesetztsein an Mineralien, Ozonbedingungen, Starklichtbedingungen, beschränkter Verfügbarkeit von Stickstoffnährstoffen und beschränkter Verfügbarkeit von Phosphornährstoffen entsprechen. 5. Treatment according to claim 4, wherein the abiotic stress conditions are one or more conditions selected from the group consisting of drought, cold stress, heat stress, drought stress, osmotic stress, waterlogging, increased soil salinity, increased exposure to minerals, ozone conditions, high light conditions, limited availability of nitrogen nutrients and limited availability of phosphorus nutrients.
6. Verwendung einer oder mehrerer Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 in der Sprühapplikation auf Pflanzen und Pflanzenteilen in Kombinationen mit einem oder mehrer Wirkstoffen ausgewählt aud der Gruppe der Insektizide, Lockstoffe, Akarizide, Fungizide, Nematizide, Herbizide, wachstumsregulatorische Stoffe, Safener, die Pflanzenreife beeinflussende Stoffe und Bakterizide. 6. The use of one or more compounds of the formula (I) or their salts as claimed in any of claims 1 to 3 in spray application to plants and parts of plants in combination with one or more active ingredients selected from the group consisting of insecticides, attractants, acaricides and fungicides , nematicides, herbicides, growth regulators, safeners, substances affecting plant maturity and bactericides.
7. Verwendung einer oder mehrerer Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 in der Sprühapplikation auf Pflanzen und Pflanzenteilen in Kombinationen mit Düngemitteln. 7. The use of one or more compounds of the formula (I) or their salts as claimed in any of claims 1 to 3 in spray application to plants and parts of plants in combination with fertilizers.
8. Verwendung einer oder mehrerer Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 zur Applikation auf gentechnisch veränderten Sorten, deren Saatgut, oder auf Anbauflächen auf denen diese Sorten wachsen. 8. The use of one or more compounds of the formula (I) or their salts as claimed in any of claims 1 to 3 for application to genetically modified varieties, their seeds, or to areas under cultivation on which these varieties grow.
9. Verwendung von Sprühlösungen, die eine oder mehrere der Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 enthalten, zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren. 9. Use of spray solutions which contain one or more of the compounds of the formula (I) or their salts as claimed in any of claims 1 to 3 for increasing the resistance of plants to abiotic stress factors.
10. Verfahren zur Erhöhung der Stresstoleranz bei Pflanzen ausgewählt aus der Gruppe der Nutzpflanzen, Zierpflanzen, Rasenarten, oder Bäumen, dadurch gekennzeichnet, dass die Applikation einer ausreichenden, nicht-toxischen Menge einer oder mehrere Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 auf die Fläche, wo die entsprechende Wirkung gewünscht wird, umfassend die Anwendung auf die Pflanzen, deren Saatgut oder auf die Fläche auf der die Pflanzen wachsen, erfolgt. 10. A method for increasing the stress tolerance in plants selected from the group of useful plants, ornamental plants, lawn species, or trees, characterized in that the application of a sufficient, non-toxic amount of one or more compounds of the formula (I) or their salts according to any one of claims 1 to 3 to the area where the corresponding effect is desired, comprising application to the plants, their seeds or to the area on which the plants are growing.
11. Substituierte N-Pyrrolidinone der allgemeinen Formel (I) oder deren Salze, worin
Figure imgf000463_0001
R1 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O- (C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl steht, R2 für Wasserstoff steht, R7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht,
Figure imgf000463_0002
R3, R4 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, OR32 stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C1-C10)- Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N- (C1-C8)-Alkyl, NR30R31, OR32, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl stehen, R8, R9, R10 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, Aryl-(C1-C8)-Alkyl, Heteroaryl-(C1-C8)-Alkyl, C(O=)R32, (C1-C8)- Alkyloxycarbonyl, Aryl-(C1-C8)-Alkyloxycarbonyl stehen, R11, R12 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)- Alkyl, R30R31N-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, OR32 stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)- Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)- alkyl, (C1-C8)-Alkylthio-(C1-C8)-alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)- Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)- alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C8)-Alkoxycarbonyl, Bis-[(C1-C8)-alkyl]aminocarbonyl- (C1-C8)-alkyl, (C1-C8)-Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl- aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl, Heteroaryl-(C1-C8)- alkoxycarbonyl, (C2-C8)-Alkenyloxycarbonyl, (C2-C8)-Alkinyloxycarbonyl, (C1-C8)- Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl- (C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl- (C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)- Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)- haloalkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)- alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkyl, Aryl, Aryl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxy-(C1-C8)- alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)- Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C8)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C8)-alkyl, Hydroxycarbonyl-(C1-C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis- [(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkylcarbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)-alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, Aryloxy-(C1-C8)-alkyl, Heteroaryloxy-(C1-C8)- alkyl, Heterocyclyloxy-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl, (C1-C8)- Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl- (C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl- (C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl steht, R33 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)- Alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino, (C1-C8)- Alkyl-amino, Aryl-(C1-C8)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C8)- alkyl]amino; Heteroaryl-(C1-C8)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C8)-alkyl]amino; Hetercyclyl-(C1-C8)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C8)-alkyl]amino; (C3-C8)-Cycloalkyl-amino, (C3-C8)-Cycloalkyl-[(C1- C8)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R37 für Phenyl, 2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6- Methylpyridin-2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2- Methylphenyl, 2,6-Dichlorphenyl, 2-Chlorpyridin-4-yl, Pyridazin-4-yl, 2- (Trifluormethyl)phenyl, 2-Cyanophenyl, 2-Bromphenyl, 2-Iodphenyl, 5-Fluor-2- methylphenyl, 5-Brom-2-methylphenyl, Pyridin-3-yl, 2-Chlorpyridin-3-yl, 2- Fluorpyridin-4-yl, 2-Fluorpyridin-3-yl steht und m für 0, 1, 2 steht. 11. Substituted N-pyrrolidinones of the general formula (I) or salts thereof, in which
Figure imgf000463_0001
R 1 is (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 10 )haloalkyl, (C 3 -C 10 ) - cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, aryl, aryl(C 1 -C 8 )alkyl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl , heterocyclyl, heterocyclyl-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-alkyl, (C 3 -C 10 )-cycloalkyl-(C 1 -C 8 )-alkyl, R 2 represents hydrogen, R 7 represents one of the following groups G-4 to G-6, where an arrow represents a bond to the pyrrolidinone ring in the general formula (I),
Figure imgf000463_0002
R 3 , R 4 are independently hydrogen, (C 1 -C 8 )-alkyl, (C 1 -C 10 )-haloalkyl, (C 3 -C 10 )-cycloalkyl, (C 3 -C 10 )-cycloalkyl- (C 1 -C 8 )alkyl, OR 32 , R 5 , R 6 are independently hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 1 -C 10 )- haloalkyl, (C 3 -C 10 )cycloalkyl, aryl-(C 1 -C 8 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 8 )-alkyl, heterocyclyl, heterocyclyl-(C 1 - C 8 )alkyl, R 32 O-(C 1 -C 8 )alkyl, R 30 R 31 N-(C 1 -C 8 )alkyl, NR 30 R 31 , OR 32 , (C 3 -C 10 )-cycloalkyl-(C 1 -C 8 )-alkyl, R 8 , R 9 , R 10 are independently hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, aryl-(C 1 -C 8 )-alkyl, heteroaryl-(C 1 -C 8 )-alkyl, C(O=)R 32 , (C 1 -C 8 )-alkyloxycarbonyl, aryl-(C 1 -C 8 )-alkyloxycarbonyl, R 11 , R 12 are independently hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 10 )haloalkyl, (C C 3 -C 10 )cycloalkyl, aryl(C 1 -C 8 )alkyl, aryl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, heterocyclyl(C 1 -C 8 )alkyl, R 32 O-(C 1 -C 8 )-alkyl, R 30 R 31 N-(C 1 -C 8 )-alkyl, (C 3 -C 10 )-cycloalkyl-(C 1 -C 8 )-alkyl, C(=O)R32 , C(= O ) OR32 , C(=O ) NR30 R31 , R32 O(O)C-( C1 -C8 )alkyl, R30 R31 N( O)C-(C 1 -C 8 )alkyl, OR 32 , R 30 and R 31 are independently hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C C 2 -C 8 ) alkynyl, (C 1 -C 8 ) cyanoalkyl, (C 1 -C 10 ) haloalkyl, (C 2 -C 8 ) haloalkenyl, (C 3 -C 8 ) haloalkynyl, (C C 3 -C 10 )cycloalkyl , (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )halocycloalkenyl, (C 1 -C 8 )alkoxy-(C 1 -C 8 )alkyl , (C 1 -C 8 )haloalkoxy(C 1 -C 8 )alkyl, (C 1 -C 8 )alkylthio(C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkylthio -(C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxy(C 1 -C 8 )haloalkyl, aryl, aryl-(C 1 -C 8 )alkyl, heteroaryl, heteroaryl-( C 1 -C 8 alkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 8 )alkyl, (C 4 -C 10 )cycloalkenyl(C 1 -C 8 )alkyl, COR 32 , SO2R 33 , heterocyclyl, (C 1 -C 8 )alkoxycarbonyl, bis[(C 1 -C 8 )alkyl]aminocarbonyl-(C 1 -C 8 )alkyl, (C 1 -C 8 )- Alkylaminocarbonyl-(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 )alkylaminocarbonyl-(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 ) alkoxycarbonyl , Heteroaryl-(C 1 -C 8 )-alkoxycarbonyl, (C 2 -C 8 )-alkenyloxycarbonyl, (C 2 -C 8 )-alkynyloxycarbonyl, (C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )- alkyl, (C 2 -C 8 )alkenyloxycarbonyl-(C 1 -C 8 )alkyl, (C 2 -C 8 )alkynyloxycarbonyl-(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 ). )-alkoxycarbonyl -(C 1 -C 8 )alkyl, heteroaryl-(C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 )alkyl, heterocyclyl-(C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 ). 8 )-alkyl, heterocyclyl-(C 1 -C 8 )-alkyl, or R 30 and R 31 with the nitrogen atom to which they are bonded is a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 3 bis form a 10-membered monocyclic or bicyclic ring, R 32 is hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 ). )cyanoalkyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 )haloalkenyl, (C 3 -C 8 )haloalkynyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )halocycloalkenyl, (C 1 -C 8 )alkoxy-(C 1 -C 8 )alkyl, (C 1 -C 8 ). )haloalkoxy(C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxy(C 1 -C 8 )haloalkyl, (C 1 -C 8 )alkoxy(C 1 -C 8 ). )-alkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-alkoxy-(C 1 -C 8 )- alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )- alkoxy-(C 1 -C 8 )alkoxy-(C 1 -C 8 )alkyl, aryl, aryl-(C 1 -C 8 )alkyl, aryl-(C 1 -C 8 )alkoxy-(C C 1 -C 8 )-alkyl, heteroaryl, heteroaryl-(C 1 -C 8 )-alkyl, (C 3 -C 8 )-cycloalkyl-(C 1 -C 8 )-alkyl, (C 4 -C 10 )- cycloalkenyl(C 1 -C 8 )alkyl, bis[(C 1 -C 8 )alkyl]aminocarbonyl(C 1 -C 8 )alkyl, (C 1 -C 8 )alkylaminocarbonyl-( C 1 -C 8 )alkyl, aryl-(C 1 -C 8 )alkylaminocarbonyl-(C 1 -C 8 )alkyl, bis[(C 1 -C 8 )alkyl]amino-(C 1 -C 8 )alkyl C 2 -C 6 )alkyl, (C 1 -C 8 )alkylamino-(C 2 -C 6 )alkyl, aryl-(C 1 -C 8 )alkylamino-(C 2 -C 6 ). )-alkyl, R 33 (O) m S-(C 1 -C 8 )-alkyl, hydroxycarbonyl-(C 1 -C 8 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 8 )-alkyl, tris- [(C 1 -C 8 )alkyl]silyl(C 1 -C 8 )alkyl, bis[(C 1 -C 8 )alkyl](aryl)silyl(C 1 -C 8 )alkyl, [(C 1 -C 8 )alkyl]bis(aryl)silyl-(C 1 -C 8 )alkyl, (C 1 -C 8 )alkylcarbonyloxy-(C 1 -C 8 )alkyl, ( C 3 -C 8 )cycloalkylcarbonylox y-(C 1 -C 8 )alkyl, arylcarbonyloxy-(C 1 -C 8 )alkyl, heteroarylcarbonyloxy-(C 1 -C 8 )alkyl, heterocyclylcarbonyloxy-(C 1 -C 8 )alkyl, aryloxy- (C 1 -C 8 )alkyl, heteroaryloxy-(C 1 -C 8 )alkyl, heterocyclyloxy-(C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxycarbonyl, (C 1 -C 8 )- alkoxycarbonyl-(C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyloxycarbonyl-(C 1 -C 8 )alkyl, (C 2 -C 8 )alkynyloxycarbonyl-(C 1 -C 8 ). )-alkyl, aryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, heteroaryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, heterocyclyl- (C 1 -C 8 )alkoxycarbonyl-(C 1 -C 8 )alkyl, R 33 is hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 - C 8 alkynyl, (C 1 -C 8 )cyanoalkyl, (C 1 -C 10 )haloalkyl, (C 2 -C 8 )haloalkenyl, (C 3 -C 8 )haloalkynyl, (C 3 - C 10 cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 10 )cycloalkenyl, (C 4 -C 10 )halocycloalkenyl, (C 1 -C 8 )alkoxy-(C 1 - C8 alkyl, (C1 -C8 ) alkoxy (C1 -C8 ) haloalkyl , aryl, aryl( C1 -C8 ) alkyl, heteroaryl , heteroaryl(C 1 -C 8 )alkyl, heterocyclyl(C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 8 )alkyl, (C 4 -C 10 )-cycloalkenyl(C 1 -C 8 )alkyl, bis[(C 1 -C 8 )alkyl]amino, (C 1 -C 8 )alkylamino, aryl(C 1 -C 8 ). )amino, aryl(C 1 -C 6 )alkylamino, aryl[(C 1 -C 8 )alkyl]amino; heteroaryl(C 1 -C 8 )amino, heteroaryl(C 1 -C 6 )alkylamino, heteroaryl[(C 1 -C 8 )alkyl]amino; heterocyclyl(C 1 -C 8 )amino, heterocyclyl(C 1 -C 6 )alkylamino, heterocyclyl[(C 1 -C 8 )alkyl]amino; (C 3 -C 8 )cycloalkylamino, (C 3 -C 8 )cycloalkyl[(C 1 -C 8 )alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R 37 is phenyl, 2-fluorophenyl, 4-fluorophenyl, 4-bromo-3-methylphenyl, 2-chlorophenyl, 4-chlorophenyl, 4-acetylphenyl, 5-chloro-2-methylphenyl, 2-chloro- 5-methylphenyl, 6-chloropyridin-3-yl, 2,5-dimethylphenyl, 2,5-difluorophenyl, 2,5-dichlorophenyl, 6-methylpyridin-2-yl, pyridin-2-yl, 2,3-dichlorophenyl, 2,6-difluorophenyl, 2-methylphenyl, 2,6-dichlorophenyl, 2-chloropyridin-4-yl, pyridazin-4-yl, 2-(trifluoromethyl)phenyl, 2-cyanophenyl, 2-bromophenyl, 2-iodophenyl, 5 -fluorine-2- methylphenyl, 5-bromo-2-methylphenyl, pyridin-3-yl, 2-chloropyridin-3-yl, 2-fluoropyridin-4-yl, 2-fluoropyridin-3-yl and m is 0,1,2.
12. Substituierte N-Pyrrolidinone der allgemeinen Formel (I) gemäß Anspruch 11 oder deren Salze, worin R1 für (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, Aryl, Aryl-(C1-C7)-Alkyl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O- (C1-C7)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C7)-Alkyl steht, R2 für Wasserstoff steht, R7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht,
Figure imgf000466_0001
R3, R4 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)- Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, OR32 stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C1-C7)- Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N- (C1-C7)-Alkyl, NR30R31, OR32, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl stehen, R8, R9, R10 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)- Alkinyl, Aryl-(C1-C7)-Alkyl, Heteroaryl-(C1-C7)-Alkyl, C(O=)R32, (C1-C7)- Alkyloxycarbonyl, Aryl-(C1-C7)-Alkyloxycarbonyl stehen, R11, R12 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)- Alkinyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)- Alkyl, R30R31N-(C1-C7)-Alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C7)-Alkyl, R30R31N(O)C-(C1-C7)-Alkyl, OR32 stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)- Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)- Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)- alkyl, (C1-C7)-Alkylthio-(C1-C7)-alkyl, (C1-C7)-Haloalkylthio-(C1-C7)-alkyl, (C1-C7)- Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)- alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C7)-Alkoxycarbonyl, Bis-[(C1-C7)-alkyl]aminocarbonyl- (C1-C7)-alkyl, (C1-C7)-Alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl- aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl, Heteroaryl-(C1-C7)- alkoxycarbonyl, (C2-C7)-Alkenyloxycarbonyl, (C2-C7)-Alkinyloxycarbonyl, (C1-C7)- Alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkinyloxycarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl- (C1-C7)-alkyl, Heteroaryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl- (C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)- Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)- haloalkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)- alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy- (C1-C7)-alkoxy-(C1-C7)-alkyl, Aryl, Aryl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxy-(C1-C7)- alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)- Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)- Alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]amino-(C2-C6)-alkyl, (C1-C7)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C7)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C7)-alkyl, Hydroxycarbonyl-(C1-C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis- [(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, (C1-C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkylcarbonyloxy-(C1-C7)-alkyl, Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)-alkyl, Heterocyclylcarbonyloxy-(C1-C7)-alkyl, Aryloxy-(C1-C7)-alkyl, Heteroaryloxy-(C1-C7)- alkyl, Heterocyclyloxy-(C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl, (C1-C7)- Alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkinyloxycarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl- (C1-C7)-alkyl, Heteroaryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl- (C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl steht, R33 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)- Alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]amino, (C1-C7)- Alkyl-amino, Aryl-(C1-C7)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C7)- alkyl]amino; Heteroaryl-(C1-C7)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C7)-alkyl]amino; Hetercyclyl-(C1-C7)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C7)-alkyl]amino; (C3-C7)-Cycloalkyl-amino, (C3-C7)-Cycloalkyl-[(C1- C7)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R37 für Phenyl, 2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6- Methylpyridin-2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2- Methylphenyl, 2,6-Dichlorphenyl, 2-Chlorpyridin-4-yl, Pyridazin-4-yl, 2- (Trifluormethyl)phenyl, 2-Cyanophenyl steht und m für 0, 1, 2 steht. 12. Substituted N-pyrrolidinones of the general formula (I) according to claim 11 or salts thereof, in which R 1 is (C 1 -C 7 )-alkyl, (C 2 -C 7 )-alkenyl, (C 2 -C 7 ) -Alkinyl, (C 1 -C 10 )haloalkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 7 )halocycloalkyl, (C 4 -C 7 )cycloalkenyl, aryl, aryl-(C 1 -C 7 )alkyl, heteroaryl, heteroaryl-(C 1 -C 7 )alkyl, heterocyclyl, heterocyclyl-(C 1 -C 7 )alkyl, R 32 O-(C 1 -C 7 )alkyl, ( C 3 -C 10 cycloalkyl-(C 1 -C 7 )alkyl, R 2 represents hydrogen, R 7 represents one of the following groups G-4 to G-6, where an arrow represents a bond to the pyrrolidinone ring in the general formula (I),
Figure imgf000466_0001
R 3 , R 4 are independently hydrogen, (C 1 -C 7 )-alkyl, (C 1 -C 7 )-haloalkyl, (C 3 -C 7 )-cycloalkyl, (C 3 -C 7 )-cycloalkyl- (C 1 -C 7 )-alkyl, OR 32 , R 5 , R 6 are independently hydrogen, (C 1 -C 7 )-alkyl, (C 2 -C 7 )-alkenyl, (C 1 -C 7 )- haloalkyl, (C 3 -C 7 )cycloalkyl, aryl-(C 1 -C 7 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 7 )-alkyl, heterocyclyl, heterocyclyl-(C 1 - C 7 )alkyl, R 32 O-(C 1 -C 7 )alkyl, R 30 R 31 N-(C 1 -C 7 )alkyl, NR 30 R 31 , OR 32 , (C 3 -C 7 )-cycloalkyl-(C 1 -C 7 )-alkyl, R 8 , R 9 , R 10 independently of one another represent hydrogen, (C 1 -C 7 )-alkyl, (C 2 -C 7 )-alkenyl, (C C 2 -C 7 )- alkynyl, aryl-(C 1 -C 7 )-alkyl, heteroaryl-(C 1 -C 7 )-alkyl, C(O=)R 32 , (C 1 -C 7 )-alkyloxycarbonyl, aryl-(C 1 -C 7 )-alkyloxycarbonyl, R 11 , R 12 are independently hydrogen, (C 1 -C 7 )-alkyl, (C 2 -C 7 )-alkenyl, (C 2 -C 7 )-alkynyl, (C 1 -C 7 )-haloalkyl, (C 3 -C 7 )cycloalkyl, aryl-(C 1 -C 7 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 7 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 7 )- alkyl, R 32 O-(C 1 -C 7 )-alkyl, R 30 R 31 N-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-cycloalkyl-(C 1 -C 7 )- Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 32 O(O)C-(C 1 -C 7 )alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-alkyl, OR 32 , R 30 and R 31 are independently hydrogen, (C 1 -C 7 )-alkyl, (C 2 -C 7 )-alkenyl, (C 2 -C 7 ) alkynyl, (C 1 -C 7 ) cyanoalkyl, (C 1 -C 7 ) haloalkyl, (C 2 -C 7 ) haloalkenyl, (C 3 -C 7 ) haloalkynyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )halocycloalkyl, (C 4 -C 7 )cycloalkenyl, (C 4 -C 7 )halocycloalkenyl, (C 1 -C 7 )alkoxy (C 1 -C 7 )alkyl, (C 1 -C 7 )haloalkoxy-(C 1 -C 7 )alkyl, (C 1 -C 7 )alkylthio-(C 1 -C 7 )alkyl, (C 1 -C 7 )haloalkylthio-(C 1 -C 7 )alkyl, (C 1 -C 7 )- alkoxy(C 1 -C 7 )haloalkyl, aryl, aryl(C 1 -C 7 )alkyl, heteroaryl, heteroaryl(C 1 -C 7 )alkyl, (C 3 -C 7 )- cycloalkyl(C 1 -C 7 )alkyl, (C 4 -C 7 )cycloalkenyl(C 1 -C 7 )alkyl, COR 32 , SO2R 33 , heterocyclyl, (C 1 -C 7 )alkoxycarbonyl, Bis[(C 1 -C 7 )alkyl]aminocarbonyl-(C 1 -C 7 )alkyl, (C 1 -C 7 )alkylaminocarbonyl-(C 1 -C 7 )alkyl, aryl-( C 1 -C 7 )alkylaminocarbonyl-(C 1 -C 7 )alkyl, aryl-(C 1 -C 7 ) alkoxycarbonyl , heteroaryl-(C 1 -C 7 )alkoxycarbonyl, (C 2 -C 7 )alkenyloxycarbonyl, (C 2 -C 7 )alkynyloxycarbonyl, (C 1 -C 7 )alkoxycarbonyl-(C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyloxycarbonyl-(C 1 -C 7 )alkyl, (C 2 -C 7 )alkynyloxycarbonyl-(C 1 -C 7 )alkyl, aryl-(C 1 -C 7 )alkoxycarbonyl-(C 1 -C 7 )alkyl, heteroaryl-( C 1 -C 7 )alkoxycarbonyl(C 1 -C 7 )alkyl, heterocyclyl(C 1 -C 7 )alkoxycarbonyl(C 1 -C 7 )alkyl, heterocyclyl(C 1 -C 7 ) -alkyl, or R 30 and R 31 with the nitrogen atom to which they are attached form a fully sat saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring, R 32 is hydrogen, (C 1 -C 7 )-alkyl, (C 2 -C 7 )-alkenyl, (C C 2 -C 7 )alkynyl, (C 1 -C 7 )cyanoalkyl, (C 1 -C 7 )haloalkyl, (C 2 -C 7 )haloalkenyl, (C 3 -C 7 )haloalkynyl, (C C 3 -C 7 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 7 )cycloalkenyl, (C 4 -C 7 )halocycloalkenyl, (C 1 -C 7 )alkoxy(C C 1 -C 7 )alkyl, (C 1 -C 7 )haloalkoxy(C 1 -C 7 )alkyl, (C 1 -C 7 )alkoxy(C 1 -C 7 )haloalkyl, (C C 1 -C 7 )alkoxy(C 1 -C 7 )alkoxy(C 1 -C 7 )alkyl, (C 1 -C 7 )alkoxy(C 1 -C 7 )alkoxy(C C 1 -C 7 )alkoxy-(C 1 -C 7 )alkyl, (C 1 -C 7 )alkoxy-(C 1 -C 7 )alkoxy-(C 1 -C 7 )alkoxy-(C C 1 -C 7 )alkoxy(C 1 -C 7 )alkyl, aryl, aryl(C 1 -C 7 )alkyl, aryl(C 1 -C 7 )alkoxy(C 1 -C 7 ). )- alkyl, heteroaryl, heteroaryl-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-cycloalkyl-(C 1 -C 7 )-alkyl, (C 4 -C 7 )- cycloalkenyl(C 1 -C 7 )alkyl, bis[(C 1 -C 7 )alkyl]aminocarbonyl(C 1 -C 7 )alkyl, (C 1 -C 7 )alkylaminocarbonyl-( C 1 -C 7 )alkyl, aryl-(C 1 -C 7 )alkylaminocarbonyl-(C 1 -C 7 )alkyl, bis[(C 1 -C 7 )alkyl]amino-(C 1 -C 7 )alkyl C 2 -C 6 )alkyl, (C 1 -C 7 )alkylamino-(C 2 -C 6 )alkyl, aryl-(C 1 -C 7 )alkylamino-(C 2 -C 6 ). )-alkyl, R 33 (O) m S-(C 1 -C 7 )-alkyl, hydroxycarbonyl-(C 1 -C 7 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 7 )-alkyl, tris- [(C 1 -C 7 )alkyl]silyl(C 1 -C 7 )alkyl, bis[(C 1 -C 7 )alkyl](aryl)silyl(C 1 -C 7 )alkyl, [(C 1 -C 7 )alkyl]bis(aryl)silyl-(C 1 -C 7 )alkyl, (C 1 -C 7 )alkylcarbonyloxy-(C 1 -C 7 )alkyl, ( C 3 -C 7 cycloalkylcarbonyloxy(C 1 -C 7 )alkyl, arylcarbonyloxy(C 1 -C 7 )alkyl, heteroarylcarbonyloxy(C 1 -C 7 )alkyl, heterocyclylcarbonyloxy(C 1 -C 7 )alkyl C 7 )alkyl, aryloxy(C 1 -C 7 )alkyl, heteroaryloxy(C 1 -C 7 )alkyl, heterocyclyloxy(C 1 -C 7 )alkyl, (C 1 -C 7 )alkoxycarbonyl , (C 1 -C 7 )alkoxycarbonyl-(C 1 -C 7 )alkyl, (C C 2 -C 7 )alkenyloxycarbonyl-(C 1 -C 7 )alkyl, (C 2 -C 7 )alkynyloxycarbonyl-(C 1 -C 7 )alkyl, aryl-(C 1 -C 7 )alkoxycarbonyl- (C 1 -C 7 )alkyl, heteroaryl-(C 1 -C 7 )alkoxycarbonyl-(C 1 -C 7 )alkyl, heterocyclyl-(C 1 -C 7 )alkoxycarbonyl-(C 1 -C 7 ). )-alkyl, R 33 is hydrogen, (C 1 -C 7 )-alkyl, (C 2 -C 7 )-alkenyl, (C 2 -C 7 )-alkynyl, (C 1 -C 7 )-cyanoalkyl, (C 1 -C 7 )haloalkyl, (C 2 -C 7 )haloalkenyl, (C 3 -C 7 )haloalkynyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )halocycloalkyl, (C 4 -C 7 )cycloalkenyl, (C 4 -C 7 )halocycloalkenyl, (C 1 -C 7 )alkoxy-(C 1 -C 7 )alkyl, (C 1 -C 7 )alkoxy (C 1 -C 7 )haloalkyl, aryl, aryl(C 1 -C 7 )alkyl, heteroaryl, heteroaryl(C 1 -C 7 )alkyl, heterocyclyl(C 1 -C 7 )alkyl, (C 3 -C 7 )cycloalkyl-(C 1 -C 7 )alkyl, (C 4 -C 10 )cycloalkenyl-(C 1 -C 7 )alkyl, bis[(C 1 -C 7 ) -alkyl]amino, (C 1 -C 7 )-alkyl-amino, aryl-(C 1 -C 7 )-amino, aryl-(C 1 -C 6 )-alkyl-amino, aryl-[(C 1 - C7 )-alkyl]amino; heteroaryl(C 1 -C 7 )amino, heteroaryl(C 1 -C 6 )alkylamino, heteroaryl[(C 1 -C 7 )alkyl]amino; heterocyclyl(C 1 -C 7 )amino, heterocyclyl(C 1 -C 6 )alkylamino, heterocyclyl[(C 1 -C 7 )alkyl]amino; (C 3 -C 7 )cycloalkylamino, (C 3 -C 7 )cycloalkyl[(C 1 -C 7 )alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R 37 is phenyl, 2-fluorophenyl, 4-fluorophenyl, 4-bromo-3-methylphenyl, 2-chlorophenyl, 4-chlorophenyl, 4-acetylphenyl, 5-chloro-2-methylphenyl, 2-chloro- 5-methylphenyl, 6-chloropyridin-3-yl, 2,5-dimethylphenyl, 2,5-difluorophenyl, 2,5-dichlorophenyl, 6-methylpyridin-2-yl, pyridin-2-yl, 2,3-dichlorophenyl, 2,6-difluorophenyl, 2-methylphenyl, 2,6-dichlorophenyl, 2-chloropyridin-4-yl, pyridazin-4-yl, 2-(trifluoromethyl)phenyl, 2-cyanophenyl; .
13. Substituierte N-Pyrrolidinone der allgemeinen Formel (I) gemäß Anspruch 11 oder deren Salze, worin R1 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O- (C1-C6)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C6)-Alkyl steht, R2 für Wasserstoff steht, R7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht,
Figure imgf000469_0001
R3, R4 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)- Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, OR32 stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C1-C6)- Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N- (C1-C6)-Alkyl, NR30R31, OR32, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl stehen, R8, R9, R10 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)- Alkyloxycarbonyl, Aryl-(C1-C6)-Alkyloxycarbonyl stehen, R11, R12 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, OR32 stehen, R30 und R31 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C6)- Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)- Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C6)-Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)- alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl, Heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)- Alkinyloxycarbonyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)- Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl- (C1-C6)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy- (C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)- Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C6)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, Hydroxycarbonyl-(C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis- [(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)- alkyl, Heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl, (C1-C6)- Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)- Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)- alkoxycarbonyl-(C1-C6)-alkyl steht, R33 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino, (C1-C6)- Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C6)- alkyl]amino; Heteroaryl-(C1-C6)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C6)-alkyl]amino; Hetercyclyl-(C1-C6)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1- C6)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R37 für Phenyl, 2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6- Methylpyridin-2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2- Methylphenyl, 2,6-Dichlorphenyl, 2-Chlorpyridin-4-yl, Pyridazin-4-yl, 2- (Trifluormethyl)phenyl, 2-Cyanophenyl steht und m für 0, 1, 2 steht. 13. Substituted N-pyrrolidinones of the general formula (I) according to claim 11 or salts thereof, in which R 1 is (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 ) -Alkinyl, (C 1 -C 10 )haloalkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, aryl, aryl-(C 1 -C 6 )-alkyl, heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-alkyl, ( C 3 -C 10 cycloalkyl-(C 1 -C 6 )alkyl, R 2 represents hydrogen, R 7 represents one of the following groups G-4 to G-6, where an arrow represents a bond to the pyrrolidinone ring in the general formula (I),
Figure imgf000469_0001
R 3 , R 4 are independently hydrogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-haloalkyl, (C 3 -C 6 )-cycloalkyl, (C 3 -C 6 )-cycloalkyl- (C 1 -C 6 )-alkyl, OR 32 , R 5 , R 6 are independently hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 1 -C 6 )- haloalkyl, (C 3 -C 6 )cycloalkyl, aryl-(C 1 -C 6 )-alkyl, aryl, heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl, heterocyclyl-(C 1 - C 6 )alkyl, R 32 O-(C 1 -C 6 )alkyl, R 30 R 31 N-(C 1 -C 6 )alkyl, NR 30 R 31 , OR 32 , (C 3 -C 6 )-cycloalkyl-(C 1 -C 6 )-alkyl, R 8 , R 9 , R 10 independently of one another are hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C C 2 -C 6 )- alkynyl, aryl-(C 1 -C 6 )-alkyl, heteroaryl-(C 1 -C 6 )-alkyl, C(O=)R 32 , (C 1 -C 6 )-alkyloxycarbonyl, Aryl-(C 1 -C 6 )-alkyloxycarbonyl, R 11 , R 12 independently of one another are hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 ) - alkynyl, (C 1 -C 6 )haloalkyl, (C 3 -C 6 )cycloalkyl, aryl-(C 1 -C 6 )alkyl, Aryl, heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, heterocyclyl, heterocyclyl-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-alkyl, R 30 R 31 N- (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, C(=O)R 32 , C(=O) OR32 , C(=O ) NR30 R31 , R32 O(O)C-( C1 -C6 )alkyl, R30 R31 N(O)C-( C1 - C 6 )-alkyl, OR 32 , R 30 and R 31 are the same or different and independently represent hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloalkenyl, (C 3 -C 6 )haloalkynyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 )halocycloalkenyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 ) 6 )alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio(C 1 -C 6 )alkyl, (C 1 -C 6 )-haloalkylthio(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )haloalkyl, aryl, aryl(C 1 -C 6 )alkyl, heteroaryl , heteroaryl(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl(C 1 -C 6 )alkyl, (C 4 -C 6 )cycloalkenyl(C 1 -C 6 ) -alkyl, COR 32 , SO2R 33 , heterocyclyl, (C 1 -C 6 )alkoxycarbonyl, bis[(C 1 -C 6 )alkyl]aminocarbonyl-(C 1 -C 6 )alkyl, (C 1 - C 6 )alkylaminocarbonyl-(C 1 -C 6 )alkyl , aryl(C 1 -C 6 )alkylaminocarbonyl(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkoxycarbonyl, heteroaryl(C 1 -C 6 )alkoxycarbonyl, ( C 2 -C 6 )alkenyloxycarbonyl, (C 2 -C 6 )alkynyloxycarbonyl, (C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyloxycarbonyl-( C 1 -C 6 )alkyl, (C 2 -C 6 )alkynyloxycarbonyl(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl , heteroaryl(C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, heterocyclyl(C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, heterocyclyl(C 1 -C 6 )-alkyl, or R 30 and R 31 with the nitrogen atom to which they are attached form a fully saturated or partially saturated 3 to 10-membered monocyclic or bicyclic ring which is optionally interrupted by heteroatoms and optionally further substituted, R 32 for hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 ). )haloalkyl, (C 2 -C 6 )haloalkenyl, (C 3 -C 6 )haloalk ynyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 10 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 )halocycloalkenyl, (C 1 -C 6 )- Alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )- haloalkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )- alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )- alkoxy-(C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, aryl, aryl-(C 1 -C 6 )alkyl, aryl-(C 1 -C 6 )alkoxy-(C C 1 -C 6 )-alkyl, heteroaryl, heteroaryl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-cycloalkyl-(C 1 -C 6 )-alkyl, (C 4 -C 6 )- cycloalkenyl(C 1 -C 6 )alkyl, bis[(C 1 -C 6 )alkyl]aminocarbonyl(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylaminocarbonyl-( C 1 -C 6 )alkyl, aryl-(C 1 -C 6 )alkylaminocarbonyl-(C 1 -C 6 )alkyl, bis[(C 1 -C 6 )alkyl]amino-(C 1 -C 6 )alkyl C 2 -C 6 )alkyl, (C 1 -C 6 )alkylamino-(C 2 -C 6 )alkyl, aryl-(C 1 -C 6 )alkylamino-(C 2 -C 6 ). ) -alkyl , R33 (O) m S-(C1 -C6 ) -alkyl, hydroxycarbonyl-(C 1 -C 6 )alkyl, Heterocyclyl, heterocyclyl(C 1 -C 6 )alkyl, tris[(C 1 -C 6 )alkyl]silyl(C 1 -C 6 )alkyl, bis[(C 1 -C 6 )- alkyl](aryl)silyl(C 1 -C 6 )alkyl, [(C 1 -C 6 )alkyl]bis(aryl)silyl(C 1 -C 6 )alkyl, (C 1 -C 6 )-alkylcarbonyloxy-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-cycloalkylcarbonyloxy-(C 1 -C 6 )-alkyl, arylcarbonyloxy-(C 1 -C 6 )-alkyl, heteroarylcarbonyloxy-( C 1 -C 6 )alkyl, heterocyclylcarbonyloxy-(C 1 -C 6 )alkyl, aryloxy-(C 1 -C 6 )alkyl, heteroaryloxy-(C 1 -C 6 )alkyl, heterocyclyloxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl, (C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyloxycarbonyl-(C 1 -C 6 )alkyl, (C 2 -C 6 )alkynyloxycarbonyl(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, heteroaryl -(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, heterocyclyl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, R 33 represents hydrogen, ( C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloalkenyl, (C 3 -C 6 )haloalkynyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )halocycloalkyl, (C 4 -C 6 )cycloalkenyl, (C 4 -C 6 )halocycloalkenyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )haloalkyl, Aryl, aryl(C 1 -C 6 )alkyl, heteroaryl, heteroaryl(C 1 -C 6 )alkyl, heterocyclyl(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl (C 1 -C 6 )alkyl, (C 4 -C 10 )cycloalkenyl-(C 1 -C 6 )alkyl, bis[(C 1 -C 6 )alkyl]amino, (C 1 -C 6 )alkyl 6 )-alkylamino, aryl(C 1 -C 6 )amino, aryl(C 1 -C 6 )alkylamino, aryl[(C 1 -C 6 )alkyl]amino; heteroaryl(C 1 -C 6 )amino, heteroaryl(C 1 -C 6 )alkylamino, heteroaryl[(C 1 -C 6 )alkyl]amino; heterocyclyl(C 1 -C 6 )amino, heterocyclyl(C 1 -C 6 )alkylamino, heterocyclyl[(C 1 -C 6 )alkyl]amino; (C 3 -C 6 )cycloalkylamino, (C 3 -C 6 )cycloalkyl[(C 1 -C 6 )alkyl]amino; N -azetidinyl, N -pyrrolidinyl, N -piperidinyl. N-morpholinyl, R 37 is phenyl, 2-fluorophenyl, 4-fluorophenyl, 4-bromo-3-methylphenyl, 2-chlorophenyl, 4-chlorophenyl, 4-acetylphenyl, 5-chloro-2-methylphenyl, 2-chloro- 5-methylphenyl, 6-chloropyridin-3-yl, 2,5-dimethylphenyl, 2,5-difluorophenyl, 2,5-dichlorophenyl, 6-methylpyridin-2-yl, pyridin-2-yl, 2,3-dichlorophenyl, 2,6-difluorophenyl, 2-methylphenyl, 2,6-dichlorophenyl, 2-chloropyridin-4-yl, pyridazin-4-yl, 2-(trifluoromethyl)phenyl, 2-cyanophenyl; .
14. Sprühlösung zur Behandlung von Pflanzen, enthaltend eine zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksame Menge einer oder mehrerer der substituierten N-Pyrrolidinone gemäß einem der Ansprüche 11 bis 13. 14. A spray solution for treating plants, containing an amount of one or more of the substituted N-pyrrolidinones according to any one of claims 11 to 13 that is effective for increasing the resistance of plants to abiotic stress factors.
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