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WO2022068173A1 - 视黄醇类包裹物及其制备方法和应用 - Google Patents

视黄醇类包裹物及其制备方法和应用 Download PDF

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Publication number
WO2022068173A1
WO2022068173A1 PCT/CN2021/086675 CN2021086675W WO2022068173A1 WO 2022068173 A1 WO2022068173 A1 WO 2022068173A1 CN 2021086675 W CN2021086675 W CN 2021086675W WO 2022068173 A1 WO2022068173 A1 WO 2022068173A1
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WO
WIPO (PCT)
Prior art keywords
retinol
thickener
polydimethylsiloxane
present disclosure
mixed oil
Prior art date
Application number
PCT/CN2021/086675
Other languages
English (en)
French (fr)
Inventor
钱进
向琼彪
李华真
李传茂
邓慧
张伟杰
曾伟丹
张楚标
Original Assignee
广州市科能化妆品科研有限公司
广东丹姿集团有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 广州市科能化妆品科研有限公司, 广东丹姿集团有限公司 filed Critical 广州市科能化妆品科研有限公司
Priority to JP2022546684A priority Critical patent/JP2023513098A/ja
Publication of WO2022068173A1 publication Critical patent/WO2022068173A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8188—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bonds, and at least one being terminated by a bond to sulfur or by a hertocyclic ring containing sulfur; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/895—Polysiloxanes containing silicon bound to unsaturated aliphatic groups, e.g. vinyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present disclosure relates to a retinol encapsulation, a preparation method and application thereof, and in particular to a retinol encapsulation, a preparation method and application thereof, and belongs to the field of cosmetics.
  • Retinoic acid (also known as: retinoic acid, retinoic acid) is a metabolic intermediate product of vitamin A in the body, and plays an important regulatory role in the process of human growth, development and cell differentiation. Retinoic acid can not only promote the synthesis of collagen, but also promote the formation of elastin fibers, which has a good anti-wrinkle effect. However, tretinoin is irritating to the skin, and symptoms such as redness and itching may occur after application. Compared with tretinoin, tretinoin (also known as: retinol) and tretinoin ester (also known as: retinol ester) are less irritating, and are usually used in cosmetics instead of tretinoin.
  • retinol or retinol ester When retinol or retinol ester penetrates into the skin, it will be gradually metabolized into retinoic acid under the oxidation of enzymes, and retinoic acid will play a role in promoting the renewal of epidermal cells. Through this metabolic process, retinoic acid is slowly released on the skin, which can not only avoid strong skin irritation, but also activate cell renewal.
  • the stability of retinol is poor, and it is easily decomposed when exposed to light and heat, especially under the action of ultraviolet rays, and it is more easily decomposed by catalytic decomposition; in addition, retinol is fat-soluble and has poor solubility in water. Therefore, the application of retinol in cosmetics has the disadvantages of instability and low utilization. How to make retinol stably exist in cosmetics and slowly release it on the skin is an important problem to be solved urgently in the current industry.
  • Citation 1 discloses a production method based on a pulsed electric field for an emulsion gel embedded with fat-soluble vitamins, which is to dissolve starch octenyl succinate in water, heat in a water bath, stir until it is completely gelatinized and dissolved, and cool to room temperature ; Add edible oil dissolved in fat-soluble vitamins to obtain a mixed solution; use a high-speed shearing machine and a high-pressure homogenizer to shear and homogenize the obtained mixed solution to obtain a coarse emulsion; add starch into the coarse emulsion, stir Evenly, an emulsion is obtained; the methylcellulose solution is added to the emulsion, and the mixture is uniformly mixed, and then treated with a pulsed electric field, heated in a water bath, degassed, and cooled to obtain an emulsion gel.
  • the fat-soluble vitamins are any one or more of retinol, beta-carotene, lycopene, lutein, tocopherol, sterols, and vitamin K.
  • the fat-soluble vitamin-embedding emulsion needs to be heated in a water bath at 80°C to 95°C, and retinol is not resistant to light and heat, and is easily damaged in the process.
  • Reference 2 discloses a method for preparing hydroxypropyl cyclodextrin inclusion retinol, comprising the following steps: (1) taking 1 part of retinol, adding 10-30 parts of purified water, and heating to 40-80° C. , stir for 0.5 to 2 hours to dissolve; (2) add 3 to 10 parts of hydroxypropyl cyclodextrin to the dissolved retinol solution, and stir at 40 to 80 ° C for 1 to 4 hours to fully encapsulate combined to obtain hydroxypropyl cyclodextrin inclusion retinol.
  • the retinol is encapsulated by hydroxypropyl cyclodextrin to form a slow-release and high-efficiency product.
  • it also needs to be heated at a temperature of 40-80° C. during the preparation process, which is easy to cause damage to the retinol. .
  • the present disclosure first provides a retinol encapsulation.
  • the retinol encapsulation of the present disclosure can form a stable encapsulation of the retinol compound, realize the sustained release of the retinol compound, and will not cause damage to the retinol compound.
  • the present disclosure also provides a method for preparing a retinol encapsulation, which does not require heating of the retinol compound during the preparation process, and will not cause damage to the retinol compound.
  • the present disclosure also provides the application of the retinol encapsulation in skin care products.
  • the retinol compound has a high utilization rate in skin care products, and can effectively remove wrinkles and resist aging.
  • the present disclosure provides a retinol encapsulation comprising the following components:
  • the thickener includes a first thickener, a second thickener and a third thickener;
  • the mass ratio of the retinol mixed oil and the first thickener is (2-4): 1;
  • the first thickener, second thickener and third thickener can be the same or different.
  • the mass ratio of the mixture of the retinol mixed oil and the first thickener, the second thickener and the third thickener is (1-1.4) : (0.05-0.08): (0.02-0.05).
  • a retinol-based wrap according to the present disclosure wherein the retinol-based mixed oil, the first thickener, the second thickener, and the third thickener form a blend that is combined with
  • the mass ratio of the polydimethylsiloxane is (1-2):1.
  • the retinol-based wrap according to the present disclosure, wherein the retinol-based mixed oil includes a retinol-based compound and a dimethicone; preferably, the retinol-based compound and the The mass ratio of the polydimethylsiloxane in the flavonoid mixed oil is (1-2): (1-2).
  • the retinol compound includes retinol and/or retinol ester.
  • the thickening agent comprises vinyl dimethicone/polymethicone silsesquioxane crosspolymer, polydimethylsiloxane One or a combination of two or more of oxane/vinyl polydimethylsiloxane cross-linked polymer and hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer.
  • the present disclosure also provides a method for preparing a retinol encapsulation, which includes the step of mixing each component of the retinol encapsulation.
  • the blend was dispersed in dimethicone to obtain a retinol-based wrap.
  • the present disclosure also provides an application of the retinol encapsulation according to the present disclosure in skin care products; preferably, the skin care products include lotions, creams, lotions, gels or essences.
  • the added amount of the retinol encapsulation is 1-5%.
  • the retinol encapsulation of the present disclosure can form a stable encapsulation for the retinol compound, realize the sustained release of the retinol compound, and will not cause damage to the retinol compound.
  • the preparation method of the retinol encapsulation of the present disclosure is simple and feasible, the raw materials are easy to obtain, the retinol compound does not need to be heated in the preparation process, the damage to the retinol compound will not be caused, and the retinol compound can be satisfied. demand for mass production.
  • the retinol encapsulation provided by the present disclosure can be applied in skin care products, improves the utilization rate of retinol compounds in skin care products, can effectively dilute fine lines, improve skin elasticity, and play an anti-aging role Effect.
  • references to “some specific/preferred embodiments”, “other specific/preferred embodiments”, “embodiments”, etc. refer to the specific elements described in relation to the embodiment (eg, features, structures, properties, and/or characteristics) are included in at least one embodiment described herein, and may or may not be present in other embodiments. Additionally, it should be understood that the described elements may be combined in any suitable manner in the various embodiments.
  • numerical range represented by "numerical value A to numerical value B” means a range including numerical values A and B at the endpoints.
  • the "water” includes deionized water, distilled water, ion-exchanged water, double-distilled water, high-purity water, purified water and any other feasible water that can be used in the cosmetic field.
  • the temperature when “normal temperature” and “room temperature” are used, the temperature may be 10-40°C.
  • a first aspect of the present disclosure provides a retinol encapsulation comprising the following components:
  • the thickener includes a first thickener, a second thickener and a third thickener;
  • the mass ratio of the retinol mixed oil and the first thickener is (2-4): 1;
  • the first thickener, second thickener and third thickener can be the same or different.
  • the thickener and the retinol mixed oil are used as the inner phase, and the polydimethylsiloxane encapsulates the thickener and the retinol mixed oil as the external phase, forming an opposite visual effect.
  • the layers of retinol compounds such as retinol and retinol ester are wrapped, so that the retinol compounds can exist stably in the package, with a sustained release effect, and will not cause retinol compounds. destroy.
  • the thickener in the retinol encapsulation can form stable adsorption to the retinol mixed oil and reduce the desorption of the retinol mixed oil. After the retinol wrap is applied to the skin surface, the wrap spreads layer by layer, so that the retinol compound is slowly released to the skin surface to exert anti-wrinkle and anti-aging effects.
  • Polydimethylsiloxane also known as dimethicone, has lubricating properties and anti-ultraviolet rays in cosmetics. It has good air permeability and obvious dust-proof function. Polydimethylsiloxane has very good permeability to the skin, which can increase the smooth and refreshing feeling of skin care products applied to the skin, and also has a good effect on increasing the softness of the skin.
  • the polydimethylsiloxane of the present disclosure can effectively stabilize the retinol compounds as an outer phase encapsulating the retinol-based mixed oil, the first thickener, the second thickener and the third thickener; After the alcohol coating is applied to skin care products, the outer layer of polydimethylsiloxane will wrap a layer of water phase, and finally form an easy-to-spread "oil-in-water" stable system.
  • the retinol-based mixed oil, the first thickener, the second thickener and the third thickener form a blend
  • the mass ratio of the blend to the polydimethylsiloxane is (1 -2): 1.
  • the mass ratio of the blend to the polydimethylsiloxane may be 1.1:1, 1.2:1, 1.3:1, 1.4:1, 1.5:1, 1.6:1, 1.7:1, 1.8:1 , 1.9:1, etc.
  • the mass ratio of the blend to the polydimethylsiloxane is (1-2): 1, the blend is fully dispersed in the polydimethylsiloxane, forming an effective effect on internal retinol compounds.
  • Package high system stability.
  • the polydimethylsiloxane is added in an amount of 35-55% based on the total mass of the retinol wrap, for example: 40%, 45% , 50%, etc.
  • the amount of polydimethylsiloxane added is 35-55%, the encapsulation can be better achieved.
  • the viscosity of the polydimethylsiloxane is 5-10 ⁇ .
  • the retinol-based oil blend of the present disclosure is formed by mixing a retinol-based compound and dimethicone.
  • Retinols are fat-soluble and can be dispersed in polydimethylsiloxane, helping to encapsulate the first layer of retinols.
  • using the same polydimethylsiloxane as the outermost layer as the oil component to mix the retinol mixture can also improve the compatibility and stability of the system.
  • the viscosity of the polydimethylsiloxane in the retinol-based mixed oil may also be 5-10 ⁇ .
  • the mass ratio of the retinol-based compound and the polydimethylsiloxane is (1-2):(1-2).
  • the mass ratio of the retinol compound and the polydimethylsiloxane is 1:1, 1:2, 2:1, etc.
  • the mass ratio of the retinol compound to the polydimethylsiloxane is (1-2):(1-2)
  • the retinol compound can be sufficiently dispersed in the polydimethylsiloxane.
  • the retinol compounds include retinol and/or retinol esters.
  • the retinol wrap is a retinol wrap formed by wrapping retinol.
  • the retinol is less irritating to the skin, and can be gradually metabolized into retinoic acid on the skin surface, thereby promoting activation and promoting Renew skin cells and improve skin elasticity to reduce fine lines, effectively remove wrinkles and anti-aging.
  • the retinol encapsulation can also be a retinol ester encapsulation formed by encapsulating retinol ester, or a mixture of encapsulating retinol and retinol ester. Compared with retinol, retinol esters have better stability, and can also be metabolized to retinoic acid to exert anti-wrinkle and anti-aging effects.
  • the retinyl esters of the present disclosure may be retinyl palmitate and/or retinyl propionate.
  • the added amount of the retinol mixed oil is 35-55%, for example: 40%, 45%, 50% etc.
  • the added amount of the retinol mixed oil is 35-55%, the effect of the retinol compound can be better exerted.
  • the thickening agent of the present disclosure includes a first thickening agent, a second thickening agent and a third thickening agent, and the first thickening agent, the second thickening agent and the third thickening agent can all use some commonly used thickening agents in the art Thickener, the three can be the same or different.
  • the first thickener, the second thickener and the third thickener By adding the first thickener, the second thickener and the third thickener, the effective adsorption of the retinol mixed oil can be formed, the viscosity of the inner phase can be increased, and the retinol compound in the retinol package can be reduced. desorption.
  • the mass ratio of the retinol-based mixed oil to the first thickener is (2-4):1.
  • the mass ratio of the retinol-based mixed oil to the first thickener may be 2.2:1, 2.5:1, 2.8:1, 3:1, 3.2:1, 3.5:1, 3.8:1 Wait.
  • the mass ratio of the retinol mixed oil and the first thickener is (2-4): 1, the first thickener can effectively adsorb the retinol mixed oil and reduce the amount of retinol in the retinol mixed oil. Retinols are desorbed.
  • the mass ratio of the mixture of the retinol mixed oil and the first thickener, the second thickener and the third thickener is (1-1.4): (0.05-0.08): (0.02- 0.05).
  • the mass ratio of the mixture of retinol mixed oil and the first thickener, the second thickener and the third thickener can be (1-1.4):(0.06-0.08):(0.02- 0.05), or (1-1.4):(0.05-0.07):(0.02-0.05), or 1:(0.06-0.08):(0.02-0.05), 1.4:(0.05-0.07):(0.02- 0.05) etc.
  • the mass ratio of the mixture of retinol mixed oil and the first thickener, the second thickener and the third thickener is (1-1.4):(0.05-0.08):(0.02-0.05)
  • It can fully encapsulate the retinol mixed oil, and is compatible with the polydimethylsiloxane of the outer phase, which is beneficial to obtain the encapsulation with stable system and high adsorption fastness of retinol compounds.
  • the thickeners include vinyl dimethicone/methicone silsesquioxane crosspolymer, dimethicone/vinyl dimethicone One or more combinations of siloxane cross-linked polymer and hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer.
  • the above-mentioned thickener component has good compatibility with other system components while adsorbing the retinol mixed oil.
  • the first thickener is vinyl dimethicone/methicone silsesquioxane crosspolymer
  • vinyl dimethicone/ Methylsiloxane Silsesquioxane Crosspolymer is a silicone powder that absorbs silicone oil, thickens and improves skin feel.
  • the second thickener is a dimethicone/vinyl dimethicone crosspolymer
  • the dimethicone/vinyl dimethicone crosspolymer is A type of silicophilic thickener that can form effective adsorption to retinol-based mixed oils.
  • the third thickener is hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer.
  • Hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer has an emulsifying effect and can improve retinol encapsulation. system stability.
  • the first thickener is added in an amount of 8-16% based on the total mass of the retinol-based package, for example: 10%, 12%, 14% %, etc.; the addition amount of the second thickener is 1-5%, for example: 2%, 3%, 4%, etc.; the addition amount of the third thickener is 0.1-2%, for example: 0.5 %, 1%, 1.5%, etc.
  • the contents of the first thickening agent, the second thickening agent and the third thickening agent are within the above ranges, the performance of the obtained retinol-based encapsulation is more excellent.
  • a thickening agent, a retinol mixed oil and polydimethylsiloxane are mixed to form a polydimethylsiloxane encapsulating the thickening agent, and the thickening agent is then encapsulated.
  • the layer-by-layer packaging of the retinol mixed oil makes the retinol compounds stably exist in the retinol package and can be slowly released on the skin surface.
  • a second aspect of the present disclosure provides a method for preparing a retinol encapsulation according to the first aspect, comprising the step of mixing each component of the retinol encapsulation.
  • the preparation method of the retinol encapsulation comprises the step of mixing each component of the retinol encapsulation at room temperature.
  • the preparation method of retinol encapsulation comprises the following steps:
  • the blend was dispersed in dimethicone to obtain a retinol-based wrap.
  • Mixing the retinol-based mixed oil with the first thickener refers to mixing the retinol-based mixed oil with the first thickener of the powder, and stirring until the first thickener of the powder changes the amount of the oil into the first thickener.
  • the retinol-based mixed oil is sucked dry to obtain a mixture of the retinol-based mixed oil and the first thickener.
  • the retinol-based mixed oil may be a retinol-based mixed oil obtained by mixing a retinol-based compound and dimethicone.
  • the blend it is a blend formed by encapsulating the retinol-based mixed oil with the powders of the first thickening agent, the second thickening agent and the third thickening agent.
  • dispersing the blend in polydimethylsiloxane means dispersing the blend in polydimethylsiloxane with a viscosity of 5-10 ⁇ , so that the outer side of the blend is finally coated with a
  • the polydimethylsiloxane of the oil phase was layered to obtain a retinol-based encapsulation in which the powder was encapsulated in the oil-phase and then the retinol-based mixed oil was encapsulated.
  • the above-mentioned mixing step and dispersion step are all carried out at room temperature, and the mixture of the retinol mixed oil and the first thickener, the second thickener and the third thickener are uniformly dispersed at the end. in polydimethylsiloxane.
  • the preparation method of the retinol compound of the present disclosure does not require heat treatment in the process of encapsulating the retinol compound, and can be carried out at room temperature without causing damage to the activity of the retinol compound, and the preparation method It is simple and easy to implement, the raw materials are easy to obtain, and it is suitable for large-scale industrial preparation.
  • a third aspect of the present disclosure provides an application of the retinol wrap described in the first aspect in a skin care product; preferably, the skin care product includes a lotion, cream, lotion, gel or essence.
  • retinol encapsulation of the present disclosure After the retinol encapsulation of the present disclosure is added to a skin care product, a layer of water phase encapsulation will be formed on the outer side of the polydimethylsiloxane, and finally a stable "oil-in-water” system is obtained, making the skin care product It has anti-aging and wrinkle-removing effects, and the active ingredient retinol compound has stable performance and long acting time.
  • the added amount of the retinol encapsulation is 1-5%, preferably 1.4-4%.
  • the retinol wrap can be added in an amount of 1.5%, 1.7%, 1.9%, 2.0%, 2.2%, 2.4%, 2.6%, 3%, 3.5%, 4.5%, and the like.
  • the added amount of the retinol wrapping is 1-5%, the effect of wrinkle removal and anti-aging can be produced, and the stimulation to human skin can be avoided, so that the product is mild and safe.
  • the present disclosure provides an anti-wrinkle cream comprising the retinol wrap according to the first aspect of the present disclosure.
  • the retinol wraps spread out layer by layer, releasing the innermost retinol compounds to promote the renewal of epidermal cells and reduce the appearance of fine lines.
  • the retinol encapsulation added in the anti-wrinkle cream has the effect of high stability and slow release, which can maximize the anti-wrinkle and anti-aging effects of the retinol compound.
  • the amount of the retinol wrap is 1-5%, preferably 1.4-2.8%.
  • the retinol wrap can be added in an amount of 1.5%, 1.7%, 1.9%, 2.0%, 2.2%, 2.4%, 2.6%, 2.8%, and the like.
  • retinol-based wraps include one or both of retinol wraps and retinol ester wraps. Both retinol wraps and retinol ester wraps have high stability, sustained release, and anti-aging and wrinkle-removing effects.
  • the anti-wrinkle cream of the present disclosure simultaneously adds a retinol wrap and a retinol ester wrap, wherein, based on the total mass of the anti-wrinkle cream, the added amount of the retinol wrap It is 0.5-1.5%, preferably 0.7-1.4%, and the added amount of the retinol ester wrap is 0.5-1.5%, preferably 0.7-1.4%.
  • the retinol ester wrap is a retinyl palmitate wrap and/or a retinyl propionate wrap.
  • the anti-wrinkle cream further includes one or a combination of two or more of moisturizing agents, emulsifiers, oils, thickeners, solvents, skin conditioning agents and preservatives.
  • the formula composition of the wrinkle-removing face cream of the present disclosure is mild, and the efficacy of the retinol wrapping of the present disclosure can be fully exerted.
  • adding a moisturizing agent can have the effect of moisturizing and replenishing water.
  • the added amount of the moisturizing agent of the present disclosure can be 1-10%, preferably 2-6%.
  • the humectant of the present disclosure is propylene glycol.
  • the system stability of the anti-wrinkle cream can be increased by adding an emulsifier, specifically, based on the total mass of the anti-wrinkle cream, the added amount of the emulsifier is 0.5-2%, preferably 0.6-1.2%.
  • the emulsifier includes PEG-20 methyl glucose sesquistearate, methyl glucose sesquistearate, sorbitan isostearate, polyglycerol-3 methyl glucose distearate One or a combination of two or more of acid esters, laureth-7 and isostearyl ether-20.
  • PEG-20 methyl sesquiglucostearate and methyl sesquiglucostearate are added to the wrinkle-removing cream at the same time; wherein, the total mass of the wrinkle-removing cream is In total, the addition amount of PEG-20 methyl sesquiglucostearate is 0.3-1.2%, and the addition amount of methyl sesquiglucostearate is 0.2-0.8%.
  • the wrinkle-removing face cream of the present disclosure further includes oil, and by adding oil to the wrinkle-removing face cream, the evaporation of moisture on the skin surface can be reduced, and the skin can be prevented from dry and cracked.
  • oil by adding oils and fats, a hydrophobic film can be formed on the skin surface, preventing the intrusion of external harmful substances.
  • the amount of oil added is 1-20%, preferably 3-15%.
  • oils and fats include one or a combination of two or more of behenyl alcohol, isononyl isononanoate, dimethiconol and polydimethylsiloxane.
  • behenyl alcohol, isononyl isononanoate, dimethiconol and dimethicone are simultaneously added to the anti-wrinkle cream.
  • the addition of behenyl alcohol is 0.5-2%, preferably 0.5-1.5%
  • the addition of isononyl isononanoate is 1-5%, preferably 1.5-2.5% %
  • the addition amount of dimethiconol is 0.5-5%, preferably 1-3%
  • the addition amount of polydimethylsiloxane is 0.5-5%, preferably 1-3%.
  • the added amount of the thickener in the anti-wrinkle cream of the present disclosure is 0.05-6%, preferably 0.7-2.5%.
  • the thickener of the present disclosure includes polydimethylsiloxane/vinyl dimethicone crosspolymer, ammonium acryloyldimethyltaurate/VP copolymer, xanthan gum, One or a combination of two or more of acrylic acid (ester)/C 10-30 alkanol acrylate cross-linked polymer and hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer.
  • polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer, ammonium acryloyldimethyltaurate/VP copolymer are added to the anti-wrinkle cream at the same time
  • acrylic (ester)/C 10-30 alkanol acrylate cross-linked polymer wherein, based on the total mass of the anti-wrinkle cream, polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked
  • the addition amount of the polymer is 0.05-2%, preferably 0.5-1.5%; the addition amount of the ammonium acryloyldimethyltaurate/VP copolymer is 0.01-2%, preferably 0.1-0.5%; acrylic acid (ester) )/C 10-30 alkanol acrylate cross-linked polymer is added in an amount of 0.01-2%, preferably 0.1-0.5%.
  • the generation of wrinkles can be reduced by adding skin conditioning agents to anti-wrinkle creams.
  • the active ingredients in skin conditioners can penetrate deep into the skin and be absorbed by the skin, thereby improving the condition of the skin.
  • the addition amount of the skin conditioning agent is 1.05-6%, preferably 1.4-4%.
  • the skin conditioning agent includes one or both of D-panthenol and niacinamide.
  • D-panthenol after D-panthenol is absorbed by the skin, it can increase the content of hyaluronic acid in the skin, give the skin luster and moisturizing effect, and can stimulate cell division and regeneration and tissue repair.
  • the added amount of D-panthenol in the anti-wrinkle cream is 0.05-2%, preferably 0.8-1.2%.
  • Niacinamide can maintain the level of ceramides and free fatty acids in the skin, maintain the moisture content of the skin, and enhance the microcirculation of the dermis.
  • the added amount of niacinamide in the anti-wrinkle cream is 1-4%, preferably 1.5-2.5%.
  • a certain amount of preservative can also be added to the anti-wrinkle cream, specifically, based on the total mass of the anti-wrinkle cream, the added amount of the anti-corrosion cream is 0.5-2%, preferably 0.6-1%.
  • the preservatives include one or a combination of two or more of methylparaben, ethylparaben, phenoxyethanol and ethylhexylglycerol.
  • each component of the anti-wrinkle cream can be fully dissolved, and the anti-wrinkle effect can be synergistically exerted.
  • the added amount of the solvent is such that the mass of the solvent and the rest of the components reach 100%.
  • water can be selected as the solvent.
  • the wrinkle-removing cream provided by the present disclosure has mild components and can synergistically synergize; the retinol encapsulation can exist stably, and the wrinkle-removing cream slowly releases the retinol compounds on the surface of the skin after smearing on the hair, so as to play an anti-wrinkle effect. Wrinkle and anti-aging effect.
  • the present disclosure also provides the preparation method of the anti-wrinkle cream according to the third aspect, including the step of mixing the components of the anti-wrinkle cream.
  • the preparation method of anti-wrinkle cream includes the following steps:
  • phase B Mix the emulsifier, grease and remaining thickener as phase B, heat phase B to 80-90°C, and keep stirring to mix phase B evenly;
  • phase B additive phase B into phase A at a temperature of 80-90 °C, and mix them evenly;
  • phase C Use the remaining preservatives and retinol wraps as phase C, when the temperature of the system drops below 40°C, add phase C, homogenize and then discharge.
  • an emulsion comprising the retinol wrap according to the first aspect of the present disclosure.
  • the retinol encapsulation added in the emulsion of the present disclosure has the effects of high stability and sustained release, and can maximize the wrinkle-removing and anti-aging effects of the retinol compound.
  • the added amount of the retinol encapsulation is 1-5%, preferably 2-4%.
  • the retinol wrap may be added in an amount of 1.5%, 1.7%, 1.9%, 2.0%, 2.2%, 2.4%, 2.6%, 2.8%, 3%, 3.5%, 4.5%, and the like.
  • the emulsion further includes one or a combination of two or more of humectants, emulsifiers, thickeners, solvents and preservatives.
  • the formulation composition of the emulsion of the present disclosure is mild, and the efficacy of the retinol encapsulation of the present disclosure can be fully exerted.
  • adding a moisturizing agent can have the effect of moisturizing and replenishing water.
  • the added amount of the moisturizing agent of the present disclosure may be 1-10%, preferably 2-6%.
  • the humectant of the present disclosure is propylene glycol.
  • the system stability of the emulsion can be increased by adding an emulsifier, specifically, based on the total mass of the emulsion, the added amount of the emulsifier is 0.1-2%, preferably 0.3-1.2%.
  • the emulsifier includes PEG-20 methyl glucose sesquistearate, methyl glucose sesquistearate, sorbitan isostearate, polyglycerol-3 methyl glucose distearate One or a combination of two or more of acid esters, laureth-7 and isostearyl ether-20.
  • PEG-20 methyl sesquiglucostearate and methyl sesquiglucostearate are simultaneously added to the emulsion; wherein, based on the total mass of the emulsion, PEG- The addition amount of 20 methyl sesquiglucostearate is 0.05-1.2%, and the addition amount of methyl sesquiglucostearate is 0.05-0.8%.
  • the added amount of the thickener in the emulsion of the present disclosure is 0.05-2%, preferably 0.1-0.8%.
  • the thickener of the present disclosure includes polydimethylsiloxane/vinyl dimethicone crosspolymer, ammonium acryloyldimethyltaurate/VP copolymer, xanthan gum, One or more combinations of acrylic acid (ester)/C 10-30 alkanol acrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer, preferably xanthogen glue.
  • a certain amount of preservative may also be added to the emulsion, specifically, based on the total mass of the emulsion, the added amount of the preservative is 0.5-2%, preferably 0.6-1%.
  • the preservatives include one or a combination of two or more of methylparaben, ethylparaben, phenoxyethanol and ethylhexylglycerol.
  • the present disclosure also provides the preparation method of the emulsion according to the third aspect, including the step of mixing each component of the emulsion.
  • the preparation method of the emulsion comprises the following steps:
  • phase A Mix the moisturizing agent, thickening agent, emulsifier, some preservatives and solvent as phase A, heat phase A to 80-90°C, keep stirring and homogenizing to make phase A evenly mixed;
  • phase B Mix the remaining preservatives and retinol encapsulations as phase B, when the temperature of the system drops below 40°C, add phase B, homogenize and then discharge.
  • Example 1-3 According to the component contents provided in Table 1, three groups of retinol encapsulations in Example 1-3 were prepared, and the preparation method of each group of retinol encapsulations specifically included the following steps:
  • retinol or retinyl palmitate and polydimethylsiloxane with a viscosity of 6 ⁇ are mixed in a mass ratio of 1:1 to obtain a retinol mixed oil.
  • retinol palmitate in embodiment 1 add retinol in embodiment 2, add the mixture of retinol and retinol palmitate in embodiment 3, wherein retinol and retinol palmitate
  • the mass ratio of the acid ester is 1:1.
  • step (2) Mix the retinol-based mixed oil obtained in step (1) with the vinyl polydimethylsiloxane/polymethylsiloxane silsesquioxane cross-linked polymer to form a powder to absorb the oil Dry.
  • step (3) mix the mixture obtained in step (3) with polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer Mixing at room temperature, and then dispersing in polydimethylsiloxane with a viscosity of 6 ⁇ , the retinol encapsulation can be prepared.
  • retinyl palmitate was added in comparative example 1
  • retinyl palmitate was added in comparative example 2
  • retinol mixed oil retinyl palmitate and polydimethylsiloxane were added.
  • the mass ratio is 1:1.
  • Example 1 The retinol encapsulation and retinyl palmitate prepared in Example 1 and Comparative Examples 1-2 were selected as the components of Phase B, and the emulsion was prepared according to the following steps:
  • the retinol wraps prepared in Examples 1-2 were selected as the C-phase components, and the wrinkle-removing creams in Application Examples 1-3 were respectively prepared, wherein the retinol wraps prepared in Examples 1-2 were respectively Corresponding to the wrinkle-removing cream of application examples 1-3, that is, the retinol ester wrap of Example 2 and the retinol wrap of Example 1 were respectively used in the wrinkle-removal cream of Example 1-2, and the application was implemented.
  • the combination of the retinol wrap of Example 1 and the retinol ester wrap of Example 2 was used in the wrinkle-removing facial cream of Example 3;
  • the preparation method includes the following steps:
  • phase B additive phase B into phase A at 85°C, and mix them evenly;
  • the samples a-d in the evaluation of the wrapping effect were selected as the samples to be tested.
  • the samples to be tested were divided into four groups, each group of two 50g transparent PET bottles, in each group, one of them was placed under natural light for 7 days, and the other was refrigerated in the dark. Seven days later, at the same time and under the same conditions, the two batches of samples to be tested were respectively analyzed by high performance liquid chromatography to quantitatively analyze the retinyl palmitate in the samples, and the residual active ingredients were calculated.
  • Table 6 The results are shown in Table 6:
  • the wrinkle-removing cream prepared by Application Example 1-3 has a better effect than the wrinkle-removing cream prepared by Application Example 1-3.
  • the actives are all retinol encapsulated, which retains the activity better than the unencapsulated actives.
  • the effect of the wrinkle-removing cream prepared in application example 1 and application example 3 is equivalent, and the effect of application of comparative example 1 is better than that of application of comparative example 3, which may be due to the fact that retinyl palmitate In the case of retinol, complete breakdown is slower.
  • the retinol encapsulation provided by the present disclosure and the preparation method and application thereof can be applied in industry.

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Abstract

涉及一种视黄醇类包裹物及其制备方法和应用，属于化妆品领域。提供了一种视黄醇类包裹物，所述视黄醇类包裹物包括以下组分：视黄醇类混合油；增稠剂；以及聚二甲基硅氧烷；其中，所述增稠剂包括第一增稠剂、第二增稠剂和第三增稠剂；所述视黄醇类混合油与第一增稠剂的质量比为（2-4）：1；并且，所述第一增稠剂、第二增稠剂以及第三增稠剂可以相同或不同。该视黄醇类包裹物能够形成对视黄醇类化合物的稳定包裹，实现视黄醇类化合物的缓释，且不会造成对视黄醇类化合物的破坏。进一步地，该视黄醇类包裹物应用于护肤品中，可提高视黄醇类化合物在护肤品中的利用率，使护肤品实现有效祛皱、抗衰老的效果。

Description

视黄醇类包裹物及其制备方法和应用 技术领域
本公开涉及一种视黄醇类包裹物及其制备方法和应用，具体涉及一种视黄醇类包裹物及其制备方法、应用，属于化妆品领域。
背景技术
维A酸(又称：维生素A酸，视黄酸)是体内维生素A的代谢中间产物，在人体生长、发育及细胞分化的过程中起着重要的调控作用。维A酸不仅可以促进胶原蛋白的合成，也能促进弹性蛋白纤维的生成，具有较好的祛皱效果。但维A酸对皮肤具有刺激性，涂抹后可能会出现发红、发痒等症状。相比于维A酸，维A醇(又称：视黄醇)与维A醇酯(又称：视黄醇酯)的刺激性低，通常代替维A酸应用于化妆品中。
当视黄醇或视黄醇酯渗透进皮肤后，会在酶的氧化作用下逐步代谢为视黄酸，视黄酸再起到促进表皮细胞更新的作用。通过这一代谢过程将视黄酸缓慢释放在皮肤上，既可以避免皮肤受到强刺激，又可以起到激活细胞更新的作用。但视黄醇的稳定性差，遇光、热易分解，尤其是在紫外线的作用下，更易被催化分解；此外，视黄醇具有脂溶性，在水中溶解性较差。因此，视黄醇应用到化妆品中存在不稳定、利用率低的缺点。如何使视黄醇稳定存在于化妆品中，并在皮肤上缓慢释放是目前行业内亟待解决的重要问题。
引用文献1公开了一种包埋脂溶性维生素的乳液凝胶的基于脉冲电场的生产方法，是将辛烯基琥珀酸淀粉酯溶解于水中，水浴加热，搅拌至完全糊化溶解，冷却至室温；加入溶有脂溶性维生素的食用油，得到混合液；使用高速剪切机和高压均质机对得到的混合液进行剪切和均质处理，得到粗乳液；将淀粉加入粗乳液中，搅拌均匀，得乳液；向乳液中加入甲基纤维素溶液，混合均匀后进行脉冲电场处理，水浴加热，脱气，冷却，得乳液凝胶。其中的脂溶性维生素为视黄醇、β-胡萝卜素、番茄红素、叶黄素、生育酚、固醇类、维生素K中的任意一种或多种。但该方法中需要将包埋脂溶性维生素的 乳液置于80℃～95℃的水浴中加热，视黄醇不耐光、热，易在该过程中遭受破坏。
引用文献2公开了一种羟丙基环糊精包合视黄醇的制备方法，包括以下步骤：(1)取视黄醇1份，加入纯化水10～30份，加热至40～80℃，搅拌0.5～2小时，使其溶解；(2)往溶解后的视黄醇溶液中加入羟丙基环糊精3～10份，在40～80℃下搅拌1～4小时，使充分包合，得到羟丙基环糊精包合视黄醇。该方法将视黄醇经过羟丙基环糊精包封形成缓释高效的产品，然而，在制备过程中同样需要在40～80℃的温度下进行加热处理，容易造成对视黄醇的破坏。
引用文献：
引用文献1：CN110693003A
引用文献2：CN110623859A
发明内容
发明要解决的问题
鉴于现有技术中存在的技术问题，例如：视黄醇稳定性差，在化妆品中利用率低，而现有的视黄醇类包裹物在对视黄醇类化合物的包裹过程中易对视黄醇类化合物造成破坏的问题等，本公开首先提供了一种视黄醇类包裹物。本公开的视黄醇类包裹物能够形成对视黄醇类化合物的稳定包裹，实现视黄醇类化合物的缓释，且不会造成对视黄醇类化合物的破坏。
进一步地，本公开还提供了视黄醇类包裹物的制备方法，该方法在制备过程中无需对视黄醇类化合物进行加热，不会造成对视黄醇类化合物的破坏。
进一步地，本公开还提供了视黄醇类包裹物在护肤品中的应用，视黄醇类化合物的在护肤品中利用率高，能够有效祛皱、抗衰老。
用于解决问题的方案
本公开提供了一种视黄醇类包裹物，其包括以下组分：
视黄醇类混合油；
增稠剂；以及
聚二甲基硅氧烷；其中，
所述增稠剂包括第一增稠剂、第二增稠剂和第三增稠剂；
所述视黄醇类混合油与第一增稠剂的质量比为(2-4):1；并且，
所述第一增稠剂、第二增稠剂以及第三增稠剂可以相同或不同。
根据本公开的视黄醇类包裹物，其中，所述视黄醇类混合油与第一增稠剂的混合物、第二增稠剂以及第三增稠剂的质量比为(1-1.4)：(0.05-0.08)：(0.02-0.05)。
根据本公开的视黄醇类包裹物，其中，所述视黄醇类混合油、第一增稠剂、第二增稠剂以及第三增稠剂形成共混物，所述共混物与所述聚二甲基硅氧烷的质量比为(1-2)：1。
根据本公开的视黄醇类包裹物，其中，所述视黄醇类混合油包括视黄醇类化合物和聚二甲基硅氧烷；优选地，所述视黄醇类化合物和所述视黄醇类混合油中的聚二甲基硅氧烷的质量比为(1-2)：(1-2)。
根据本公开的视黄醇类包裹物，其中，所述视黄醇类化合物包括视黄醇和/或视黄醇酯。
根据本公开的视黄醇类包裹物，其中，所述增稠剂包括乙烯基聚二甲基硅氧烷/聚甲基硅氧烷硅倍半氧烷交联聚合物、聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物以及丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物中的一种或两种以上的组合。
本公开还提供了一种视黄醇类包裹物的制备方法，其包括将所述视黄醇类包裹物的各组分混合的步骤。
根据本公开的制备方法，其中，包括以下步骤：
将视黄醇类混合油与第一增稠剂混合；
将视黄醇类混合油与第一增稠剂的混合物、第二增稠剂以及第三增稠剂混合，得到共混物；
将所述共混物分散在聚二甲基硅氧烷中，得到视黄醇类包裹物。
本公开还提供了一种根据本公开所述的视黄醇类包裹物在护肤品中的应用；优选地，所述护肤品包括化妆水、膏霜、乳液、啫喱或者精华。
根据本公开的应用，其中，所述护肤品中，所述视黄醇类包裹物的添加 量为1-5％。
发明的效果
本公开的视黄醇类包裹物，能够形成对视黄醇类化合物的稳定包裹，实现视黄醇类化合物的缓释，且不会造成对视黄醇类化合物的破坏。
进一步地，本公开的视黄醇类包裹物的制备方法简单易行，原料易于获取，制备过程中无需对视黄醇类化合物进行加热，不会造成对视黄醇类化合物的破坏，能够满足大批量生产的需求。
进一步地，本公开提供的视黄醇类包裹物能够在护肤品中的应用，提高了视黄醇类化合物在护肤品中的利用率，能够有效淡化细纹、改善皮肤弹性，起到抗衰老的效果。
具体实施方式
以下将详细说明本公开的各种示例性实施例、特征和方面。在这里专用的词“示例性”意为“用作例子、实施例或说明性”。这里作为“示例性”所说明的任何实施例不必解释为优于或好于其它实施例。
另外，为了更好地说明本公开，在下文的具体实施方式中给出了众多的具体细节。本领域技术人员应当理解，没有某些具体细节，本公开同样可以实施。在另外一些实例中，对于本领域技术人员熟知的方法、手段、器材和步骤未作详细描述，以便于凸显本公开的主旨。
如无特殊声明，本说明书中所使用的单位均为国际标准单位，并且本公开中出现的数值，数值范围，均应当理解为包含了工业生产中所不可避免的系统性误差。
本说明书中，如没有特别说明，则“％”均表示质量百分含量。
本说明书中，使用“可以”表示的含义包括了进行某种处理以及不进行某种处理两方面的含义。
本说明书中，所提及的“一些具体/优选的实施方案”、“另一些具体/优选的实施方案”、“实施方案”等是指所描述的与该实施方案有关的特定要素(例如，特征、结构、性质和/或特性)包括在此处所述的至少一种实施方案中， 并且可存在于其它实施方案中或者可不存在于其它实施方案中。另外，应理解，所述要素可以任何合适的方式组合在各种实施方案中。
本说明书中，使用“数值A～数值B”表示的数值范围是指包含端点数值A、B的范围。
另外，本说明书中，所述“水”包含去离子水、蒸馏水、离子交换水、双蒸水、高纯水、纯净水等化妆品领域能够使用的任何可行的水。
本说明书中，使用“常温”、“室温”时，其温度可以是10-40℃。
第一方面
本公开的第一方面提供了一种视黄醇类包裹物，包括以下组分：
视黄醇类混合油；
增稠剂；以及
聚二甲基硅氧烷；其中，
所述增稠剂包括第一增稠剂、第二增稠剂和第三增稠剂；
所述视黄醇类混合油与第一增稠剂的质量比为(2-4):1；并且，
所述第一增稠剂、第二增稠剂以及第三增稠剂可以相同或不同。
本公开的视黄醇类包裹物，其中的增稠剂和视黄醇类混合油作为内相，聚二甲基硅氧烷包裹增稠剂和视黄醇类混合油作为外相，形成对视黄醇、视黄醇酯等视黄醇类化合物的层层包裹，使视黄醇类化合物能够稳定存在于包裹物中，具有缓释的效果，并且不会造成对视黄醇类化合物活性的破坏。视黄醇类包裹物中的增稠剂可以形成对视黄醇类混合油的稳定吸附，减少视黄醇类混合油的脱附。视黄醇类包裹物被应用到皮肤表面后，包裹物逐层铺展，使视黄醇类化合物被缓慢释放到皮肤表面，发挥除皱抗衰效果。
聚二甲基硅氧烷
聚二甲基硅氧烷又称二甲硅油，在化妆品中，具有润滑性能、抗紫外线的作用，其透气性好，具有明显的防尘功能，可用来取代传统的油脂原料。聚二甲基硅氧烷对皮肤的渗透性非常好，可增加护肤品涂抹在皮肤上的顺滑清爽感受，对于增加皮肤的柔软性也有不错的效果。本公开的聚二甲基硅氧烷作为包裹视黄醇类混合油、第一增稠剂、第二增稠剂以及第三增稠剂的外 相，能够有效稳定视黄醇类化合物；视黄醇类包裹物在应用于护肤品后，聚二甲基硅氧烷的外层又会包裹一层水相，最终形成易铺展的“水包油”稳定体系。
所述视黄醇类混合油、第一增稠剂、第二增稠剂以及第三增稠剂形成共混物，所述共混物与聚二甲基硅氧烷的质量比为(1-2)：1。具体地，共混物与聚二甲基硅氧烷的质量比可以是1.1:1，1.2:1，1.3:1，1.4:1，1.5:1，1.6:1，1.7:1，1.8:1，1.9:1等。当共混物与聚二甲基硅氧烷的质量比为(1-2)：1时，共混物充分分散于聚二甲基硅氧烷中，形成对内部视黄醇类化合物的有效包裹，体系稳定性高。
进一步，在另一些具体的实施方案中，以所述视黄醇类包裹物的总质量计，所述聚二甲基硅氧烷的加入量为35-55％，例如：40％、45％、50％等。当聚二甲基硅氧烷的加入量为35-55％时，能够更好的实现包裹。作为优选，在本公开中，聚二甲基硅氧烷的粘度为5-10η。
视黄醇类混合油
本公开的视黄醇类混合油是以视黄醇类化合物和聚二甲基硅氧烷混合形成。视黄醇类化合物具有脂溶性，能够分散于聚二甲基硅氧烷中，有助于对视黄醇类化合物的第一层包裹。此外，采用与最外层相同的聚二甲基硅氧烷作为油脂成分混合视黄醇类混合物，还可提高体系的相容性与稳定性。作为优选，视黄醇类混合油中的聚二甲基硅氧烷的粘度也可以为5-10η。
具体地，视黄醇类混合油中，所述视黄醇类化合物和所述聚二甲基硅氧烷的质量比为(1-2)：(1-2)。例如，所述视黄醇类化合物和所述聚二甲基硅氧烷的质量比为1:1，1:2，2:1等。当视黄醇类化合物与聚二甲基硅氧烷的质量比为(1-2)：(1-2)时，能够使视黄醇类化合物充分分散于聚二甲基硅氧烷中。
进一步地，所述视黄醇类化合物包括视黄醇和/或视黄醇酯。在一些具体的实施方式中，视黄醇类包裹物是包裹视黄醇形成的视黄醇包裹物，视黄醇对皮肤的刺激性小，在皮肤表面可逐步代谢为视黄酸，激活促进皮肤细胞更新，提高皮肤弹性，以淡化细纹，有效除皱抗衰老。在另外一些具体的实施 方式中，视黄醇类包裹物还可以是包裹视黄醇酯形成的视黄醇酯包裹物，或者包裹视黄醇与视黄醇酯的混合物。与视黄醇相比，视黄醇酯的稳定性更好，并且同样可以通过代谢为视黄酸发挥祛皱抗衰老的功效。
在一些具体的实施方案中，本公开的视黄醇酯可以是视黄醇棕榈酸酯和/或视黄醇丙酸酯。
进一步，在另一些具体的实施方案中，以所述视黄醇类包裹物的总质量计，所述视黄醇类混合油的加入量为35-55％，例如：40％、45％、50％等。当视黄醇类混合油的加入量为35-55％时，能够使视黄醇类化合物的功效得到更好的发挥。
增稠剂
本公开增稠剂包括第一增稠剂、第二增稠剂和第三增稠剂，第一增稠剂、第二增稠剂和第三增稠剂均可使用本领域常用的一些增稠剂，三者可以相同或不同。通过添加第一增稠剂、第二增稠剂和第三增稠剂，可以形成对视黄醇类混合油的有效吸附，增加内相的黏度，减少视黄醇类包裹物中视黄醇化合物的脱附。
在一些具体的实施方案中，所述视黄醇类混合油与第一增稠剂的质量比为(2-4):1。举例而言，所述视黄醇类混合油与第一增稠剂的质量比可以是2.2:1，2.5:1，2.8:1，3:1，3.2:1，3.5:1，3.8:1等。当视黄醇类混合油与第一增稠剂的质量比为(2-4):1时，第一增稠剂能够有效吸附视黄醇类混合油，减少视黄醇类混合油中的视黄醇类化合物发生脱附。
具体地，所述视黄醇类混合油与第一增稠剂的混合物、第二增稠剂以及第三增稠剂的质量比为(1-1.4):(0.05-0.08)：(0.02-0.05)。举例而言，视黄醇类混合油与第一增稠剂的混合物、第二增稠剂以及第三增稠剂的质量比可以是(1-1.4):(0.06-0.08)：(0.02-0.05)，还可以是(1-1.4):(0.05-0.07)：(0.02-0.05)，或者1：(0.06-0.08)：(0.02-0.05)、1.4：(0.05-0.07)：(0.02-0.05)等。当视黄醇类混合油与第一增稠剂的混合物、第二增稠剂以及第三增稠剂的质量比为(1-1.4):(0.05-0.08)：(0.02-0.05)时，能够形成对视黄醇类混合油的充分包裹，并与外相的聚二甲基硅氧烷相容，有利于获得体系稳定、视黄醇类化 合物吸附牢度高的包裹物。
在本公开中，所述增稠剂包括乙烯基聚二甲基硅氧烷/聚甲基硅氧烷硅倍半氧烷交联聚合物、聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物以及丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物中的一种或两种以上的组合。上述增稠剂成分在吸附视黄醇类混合油的同时，还与其他体系成分具有良好的相容性。
在一些具体的实施方式中，第一增稠剂为乙烯基聚二甲基硅氧烷/聚甲基硅氧烷硅倍半氧烷交联聚合物，乙烯基聚二甲基硅氧烷/聚甲基硅氧烷硅倍半氧烷交联聚合物是一种有机硅粉末，这种有机硅粉末能够吸收硅油，具有增稠和改善肤感的效果。第二增稠剂为聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物，聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物是一类亲硅性的增稠剂，能够形成对视黄醇类混合油的有效吸附。第三增稠剂为丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物，丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物具有乳化效果，可以提高视黄醇类包裹物的体系稳定性。
进一步，在另一些具体的实施方案中，以所述视黄醇类包裹物的总质量计，所述第一增稠剂的加入量为8-16％，例如：10％、12％、14％等；所述第二增稠剂的加入量为1-5％，例如：2％、3％、4％等；所述第三增稠剂的加入量为0.1-2％，例如：0.5％、1％、1.5％等。当第一增稠剂、第二增稠剂以及第三增稠剂的含量在上述范围内时，所获得的视黄醇类包裹物的性能更加优异。
本公开的视黄醇类包裹物，以增稠剂、视黄醇类混合油与聚二甲基硅氧烷相混合，形成聚二甲基硅氧烷包裹增稠剂，增稠剂再包裹视黄醇类混合油的层层包裹的形式，使视黄醇类化合物稳定存在于视黄醇类包裹物内，在皮肤表面可缓慢释放。
第二方面
本公开的第二方面提供了一种第一方面所述的视黄醇类包裹物的制备方法，包括将所述视黄醇类包裹物的各组分混合的步骤。
进一步地，所述视黄醇类包裹物的制备方法，包括在室温下将所述视黄 醇类包裹物的各组分混合的步骤。
在一些具体的实施方式中，视黄醇类包裹物的制备方法包括以下步骤：
将视黄醇类混合油与第一增稠剂混合；
将视黄醇类混合油与第一增稠剂的混合物、第二增稠剂以及第三增稠剂混合，得到共混物；
将所述共混物分散在聚二甲基硅氧烷中，得到视黄醇类包裹物。
对于将视黄醇类混合油与第一增稠剂混合，是指将视黄醇类混合油与粉体的第一增稠剂混合，搅拌至粉体的第一增稠剂将油体的视黄醇类混合油吸干，得到视黄醇类混合油与第一增稠剂的混合物。
进一步地，对于视黄醇类混合油，可以是将视黄醇类化合物与聚二甲基硅氧烷混合得到的视黄醇类混合油。
对于共混物，是第一增稠剂、第二增稠剂和第三增稠剂的粉体包裹视黄醇类混合油形成的共混物。
对于将所述共混物分散在聚二甲基硅氧烷中，是指将共混物分散于粘度为5-10η的聚二甲基硅氧烷中，使共混物的外侧最终包裹一层油相的聚二甲基硅氧烷，得到以油相包裹粉体再包裹视黄醇类混合油的视黄醇类包裹物。
进一步地，上述的混合步骤和分散步骤均在室温下进行，最终混合均匀的视黄醇类混合油与第一增稠剂的混合物、第二增稠剂以及第三增稠剂的混合物均匀分散于聚二甲基硅氧烷中。
本公开的视黄醇类包裹物的制备方法，在包裹视黄醇类化合物的过程中不需要加热处理，室温下即可实施，不会造成视对黄醇类化合物活性的破坏，且制备方法简单易行，原料易于获取，适合大规模的工业制备。
第三方面
本公开的第三方面提供了一种第一方面所述的视黄醇类包裹物在护肤品中的应用；优选地，所述护肤品包括化妆水、膏霜、乳液、啫喱或者精华。
本公开的视黄醇类包裹物在添加于护肤品中后，聚二甲基硅氧烷的外侧会再形成一层水相包裹物，最终得到稳定的“水包油”体系，使护肤品具有抗衰、除皱的效果，且活性成分视黄醇类化合物性能稳定、作用时间长。
具体地，以所述护肤品的总质量计，所述视黄醇类包裹物的添加量为1-5％，优选1.4-4％。例如，视黄醇类包裹物的加入量可以是1.5％、1.7％、1.9％、2.0％、2.2％、2.4％、2.6％、3％、3.5％、4.5％等等。当视黄醇类包裹物的加入量为1-5％时，即能产生祛皱、抗衰老的效果，又能避免对人体肌肤造成刺激，使产品温和安全。
祛皱面霜
在一些具体的实施方式中，本公开提供了一种祛皱面霜，其包括根据本公开第一方面所述的视黄醇类包裹物。祛皱面霜在涂抹于皮肤表面后，视黄醇类包裹物层层铺展，将最内层的视黄醇类化合物释放出来，发挥促进表皮细胞更新、淡化细纹的作用。祛皱面霜中添加的视黄醇类包裹物具有稳定性高以及缓释的效果，可以使视黄醇类化合物的祛皱、抗衰老效果得到最大程度的发挥。
具体地，以祛皱面霜的总质量计，视黄醇类包裹物的加入量为1-5％，优选1.4-2.8％。例如，视黄醇类包裹物的加入量可以是1.5％、1.7％、1.9％、2.0％、2.2％、2.4％、2.6％、2.8％等等。
在本公开中，视黄醇类包裹物包括视黄醇包裹物和视黄醇酯包裹物中的一种或两种。视黄醇包裹物和视黄醇酯包裹物均具有稳定性高、缓释，以及抗衰除皱的效果。在一些更为具体的实施方式中，本公开的祛皱面霜同时添加视黄醇包裹物和视黄醇酯包裹物，其中，以祛皱面霜的总质量计，视黄醇包裹物的加入量为0.5-1.5％，优选0.7-1.4％，视黄醇酯包裹物的加入量为0.5-1.5％，优选0.7-1.4％。在一些更为具体的实施方式中，视黄醇酯包裹物为视黄醇棕榈酸酯包裹物和/或视黄醇丙酸酯包裹物。
在一些具体的实施方式中，祛皱面霜还包括保湿剂、乳化剂、油脂、增稠剂、溶剂、皮肤调理剂和防腐剂中的一种或两种以上的组合。本公开的祛皱面霜的配方组成温和，可以使本公开的视黄醇类包裹物的功效得到充分发挥。
在本公开中，添加保湿剂能够起到保湿补水的效果。为使保湿剂的功效能够进一步发挥，以祛皱面霜的总质量计，本公开的保湿剂的加入量可以是 1-10％，优选为2-6％。进一步地，本公开的保湿剂为丙二醇。
在本公开中，通过添加乳化剂能够增加祛皱面霜的体系稳定性，具体地，以祛皱面霜的总质量计，乳化剂的加入量为0.5-2％，优选0.6-1.2％。
进一步地，乳化剂包括PEG-20甲基葡糖倍半硬脂酸酯、甲基葡糖倍半硬脂酸酯、山梨坦异硬脂酸酯、聚甘油-3甲基葡糖二硬脂酸酯、月桂醇聚醚-7、异硬脂醇聚醚-20中的一种或两种以上的组合。
在另一些具体的实施方案中，祛皱面霜中同时添加有PEG-20甲基倍半葡糖硬脂酸酯和甲基倍半葡糖硬脂酸酯；其中，以祛皱面霜的总质量计，PEG-20甲基倍半葡糖硬脂酸酯的添加量为0.3-1.2％，甲基倍半葡糖硬脂酸酯的添加量为0.2-0.8％。
在本公开中，本公开的祛皱面霜中还包括油脂，通过在祛皱面霜中添加油脂，可以减少皮肤表面水分的蒸发，防止皮肤干裂。另外，通过添加油脂，可以在皮肤表面形成疏水性薄膜，防止外部有害物质的侵入。具体地，以祛皱面霜的总质量计，油脂的加入量为1-20％，优选为3-15％。
进一步地，油脂包括山嵛醇、异壬酸异壬酯、聚二甲基硅氧烷醇以及聚二甲基硅氧烷中的一种或两种以上的组合。
在一些更为具体的实施方式中，祛皱面霜中同时添加有山嵛醇、异壬酸异壬酯、聚二甲基硅氧烷醇以及聚二甲基硅氧烷。其中，以祛皱面霜的总质量计，山嵛醇的加入量为0.5-2％，优选为0.5-1.5％；异壬酸异壬酯的加入量为1-5％，优选为1.5-2.5％；聚二甲基硅氧烷醇的加入量为0.5-5％，优选为1-3％；聚二甲基硅氧烷的加入量为0.5-5％，优选为1-3％。
在本公开中，通过添加增稠剂以控制祛皱面霜的质地，得到合适的稠度，且稳定性优异。具体地，以祛皱面霜的总质量计，本公开的祛皱面霜中的增稠剂的加入量为0.05-6％，优选0.7-2.5％。
进一步地，本公开的增稠剂包括聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物、丙烯酰二甲基牛磺酸铵/VP共聚物、黄原胶、丙烯酸(酯)类/C 10-30烷醇丙烯酸酯交联聚合物、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物中的一种或两种以上的组合。
在一些具体的实施方案中，祛皱面霜中同时添加有聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物、丙烯酰二甲基牛磺酸铵/VP共聚物以及丙烯酸(酯)类/C 10-30烷醇丙烯酸酯交联聚合物；其中，以祛皱面霜的总质量计，聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物的加入量为0.05-2％，优选为0.5-1.5％；丙烯酰二甲基牛磺酸铵/VP共聚物的加入量为0.01-2％，优选为0.1-0.5％；丙烯酸(酯)类/C 10-30烷醇丙烯酸酯交联聚合物的加入量为0.01-2％，优选为0.1-0.5％。
在本公开中，通过在祛皱面霜中添加皮肤调理剂，可以减少皱纹的产生。皮肤调理剂中的有效成分，可以渗透到肌肤深处，被皮肤吸收，从而改善皮肤的状态。具体地，以祛皱面霜的总质量计，皮肤调理剂的加入量为1.05-6％，优选1.4-4％。
进一步地，皮肤调理剂包括D-泛醇和烟酰胺中的一种或两种。其中，D-泛醇经皮肤吸收后，可增加肌肤中玻尿酸含量，给予肌肤光泽及保湿作用，能刺激细胞分裂再生并组织修复。D-泛醇在祛皱面霜中的加入量为0.05-2％，优选0.8-1.2％。烟酰胺可维持肌肤中神经酰胺和游离脂肪酸水平，维持肌肤含水量，增进真皮层微循环。烟酰胺在祛皱面霜中的加入量为1-4％，优选1.5-2.5％。
在本公开中，祛皱面霜中还可以添加一定量的防腐剂，具体地，以祛皱面霜的总质量计，防腐剂的加入量为0.5-2％，优选为0.6-1％。
进一步地，防腐剂包括羟苯甲酯、羟苯乙酯、苯氧乙醇及乙基己基甘油中的一种或两种以上的组合。
进一步地，祛皱面霜中还可以添加不影响其功效的其他组分。
在本公开中，通过添加溶剂，可以使祛皱面霜的各组分充分溶解，协同发挥祛皱效果。具体地，以祛皱面霜的总质量计，溶剂的加入量为使溶剂与其余组分的质量和达到100％的加入量。进一步地，可以选择水作为溶剂。
本公开提供的祛皱面霜，组分温和，可协同增效；其中的视黄醇类包裹物可稳定存在，祛皱面霜在发涂抹后将视黄醇类化合物缓释于皮肤表面，发挥祛皱、抗衰老的效果。
进一步地，本公开还提供了第三方面所述的祛皱面霜的制备方法，包括将所述祛皱面霜的各组分混合的步骤。
在一些具体的实施方式中，祛皱面霜的制备方法包括如下步骤：
将保湿剂、皮肤调理剂、部分增稠剂、部分防腐剂和溶剂混合作为A相，A相加热至80-90℃，持续搅拌使A相混合均匀；
将乳化剂、油脂和剩余的增稠剂混合作为B相，B相加热至80-90℃，持续搅拌使B相混合均匀；
在80-90℃的温度下将B相加入A相中，均质混合均匀；
以剩余的防腐剂和视黄醇类包裹物作为C相，待体系温度降至40℃以下时，加入C相，均质均匀后出料。
乳液
在本公开中，还提供了一种乳液，其包括根据本公开第一方面所述的视黄醇类包裹物。本公开乳液中添加的视黄醇类包裹物具有稳定性高以及缓释的效果，可以使视黄醇类化合物的祛皱、抗衰老效果得到最大程度的发挥。
具体地，以乳液的总质量计，视黄醇类包裹物的加入量为1-5％，优选2-4％。例如，视黄醇类包裹物的加入量可以是1.5％、1.7％、1.9％、2.0％、2.2％、2.4％、2.6％、2.8％、3％、3.5％、4.5％等等。
在一些具体的实施方式中，乳液还包括保湿剂、乳化剂、增稠剂、溶剂和防腐剂中的一种或两种以上的组合。本公开的乳液的配方组成温和，可以使本公开的视黄醇类包裹物的功效得到充分发挥。
在本公开中，添加保湿剂能够起到保湿补水的效果。为使保湿剂的功效能够进一步发挥，以乳液的总质量计，本公开的保湿剂的加入量可以是1-10％，优选为2-6％。进一步地，本公开的保湿剂为丙二醇。
在本公开中，通过添加乳化剂能够增加乳液的体系稳定性，具体地，以乳液的总质量计，乳化剂的加入量为0.1-2％，优选0.3-1.2％。
进一步地，乳化剂包括PEG-20甲基葡糖倍半硬脂酸酯、甲基葡糖倍半硬脂酸酯、山梨坦异硬脂酸酯、聚甘油-3甲基葡糖二硬脂酸酯、月桂醇聚醚-7、异硬脂醇聚醚-20中的一种或两种以上的组合。
在另一些具体的实施方案中，乳液中同时添加有PEG-20甲基倍半葡糖硬脂酸酯和甲基倍半葡糖硬脂酸酯；其中，以乳液的总质量计，PEG-20甲基倍半葡糖硬脂酸酯的添加量为0.05-1.2％，甲基倍半葡糖硬脂酸酯的添加量为0.05-0.8％。
在本公开中，通过添加增稠剂以控制乳液的质地，得到合适的稠度，且稳定性优异。具体地，以乳液的总质量计，本公开的乳液中的增稠剂的加入量为0.05-2％，优选0.1-0.8％。
进一步地，本公开的增稠剂包括聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物、丙烯酰二甲基牛磺酸铵/VP共聚物、黄原胶、丙烯酸(酯)类/C 10-30烷醇丙烯酸酯交联聚合物、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物中的一种或两种以上的组合，优选使用黄原胶。
在本公开中，乳液中还可以添加一定量的防腐剂，具体地，以乳液的总质量计，防腐剂的加入量为0.5-2％，优选为0.6-1％。进一步地，防腐剂包括羟苯甲酯、羟苯乙酯、苯氧乙醇及乙基己基甘油中的一种或两种以上的组合。
进一步地，本公开还提供了第三方面所述的乳液的制备方法，包括将所述乳液的各组分混合的步骤。
在一些具体的实施方式中，乳液的制备方法包括如下步骤：
将保湿剂、增稠剂、乳化剂、部分防腐剂和溶剂混合作为A相，A相加热至80-90℃，持续搅拌、均质使A相混合均匀；
将剩余的防腐剂、视黄醇类包裹物混合作为B相，待体系温度降至40℃以下时，加入B相，均质均匀后出料。
实施例
下面将结合实施例对本公开的实施方案进行详细描述，但是本领域技术人员将会理解，下列实施例仅用于说明本公开，而不应视为限定本公开的范围。实施例中未注明具体条件者，按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者，均为可以通过市购获得的常规产品。
实施例1-3
按照表1中提供的组分含量制备实施例1-3中三组的视黄醇类包裹物， 每组视黄醇类包裹物的制备方法具体包括如下步骤：
(1)在室温下将视黄醇或视黄醇棕榈酸酯与粘度为6η的聚二甲基硅氧烷按质量比1：1比例混合，得到视黄醇类混合油。
其中，实施例1中加入视黄醇棕榈酸酯，实施例2中加入视黄醇，实施例3中加入视黄醇与视黄醇棕榈酸酯的混合物，其中视黄醇与视黄醇棕榈酸酯的质量比为1:1。
(2)将步骤(1)所得的视黄醇类混合油与乙烯基聚二甲基硅氧烷/聚甲基硅氧烷硅倍半氧烷交联聚合物混合至粉体将油体吸干。
(3)将步骤(3)所得的混合物与聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物在室温下混合，然后分散在粘度为6η的聚二甲基硅氧烷中，即可制得视黄醇类包裹物。
表1
Figure PCTCN2021086675-appb-000001
对比例1-2
按照实施例1-3中提供的制备方法，以表2中提供的数据，分别制备对比例1-2中的两组视黄醇类包裹物。其中，对比例1中加入视黄醇棕榈酸酯，对比例2中加入视黄醇棕榈酸酯，并且，视黄醇类混合油中，视黄醇棕榈酸酯与聚二甲基硅氧烷的质量比为1：1。
表2
Figure PCTCN2021086675-appb-000002
应用实施例a以及应用对比例b-d
选取实施例1、对比例1-2所制备的视黄醇类包裹物以及视黄醇棕榈酸酯作为B相的组分，按照如下步骤制备乳液：
(1)将A相组分混合，加热至85℃，均质使其混合均匀；
(2)待体系温度降至40℃以下时，加入B相组分，均质均匀后出料。
表3
Figure PCTCN2021086675-appb-000003
应用实施例1-3
选取实施例1-2制备的视黄醇类包裹物作为C相组分，分别制备应用实施例1-3中的祛皱面霜，其中，实施例1-2制备的视黄醇类包裹物分别对应于应用实施例1-3的祛皱面霜，即应用实施例1-2的祛皱面霜中分别使用实施例2的视黄醇酯包裹物和实施例1的视黄醇包裹物，应用实施例3的祛皱面霜中使用实施例1的视黄醇包裹物和实施例2的视黄醇酯包裹物的组合；祛皱面霜中 其他物质组分具体如表4所示，祛皱面霜的制备方法包括如下步骤：
(1)将A、B两相组分混合后分别加热至85℃，持续搅拌使A、B两相分别混合均匀；
(2)在85℃下将B相加入A相中，均质混合均匀；
(3)待体系温度降至40℃以下时，加入C相，均质均匀后出料。
表4应用实施例1-3
Figure PCTCN2021086675-appb-000004
应用对比例1-3
按照应用实施例1-3中提供的制备方法，以表5中提供的数据，分别制备应用对比例1-3中的两组祛皱面霜。
表5应用对比例1-3
Figure PCTCN2021086675-appb-000005
效果评价实验
1、包裹效果评价
选取包裹效果评价中的样品a-d为待测样品。将待测样品分别分装在四组，每组两个50g的透明PET瓶中，每一组中，其中一个置于自然光下光照7天，另一个避光冷藏。7天后，在同一时间且在同一条件下分别对两批待测样品采用高效液相色谱仪对样品中的视黄醇棕榈酸酯进行定量分析，并计算残余的有效成分。其结果如表6所示：
表6包裹效果评价
样品 避光冷藏(％) 光照后含量(％) 残余量(％)
样品a 0.482 0.285 59.1％
样品b 0.474 0.172 36.4％
样品c 0.465 0.155 33.4％
样品d 0.468 0.189 40.9％
由表6包裹效果评价结果可以看出，经过光照7天实验后，样品a中的视 黄醇棕榈酸酯的残余量最高，可以达到59.1％，样品d次之为40.9％，样品b、c的含量最低。根据实验结果可以看出，本公开提供的视黄醇类包裹物经光照7天后残余量较未被包裹视黄醇棕榈酸酯能够提升20％左右，说明视黄醇类包裹物能够有效提高视黄醇类化合物的稳定性。
2、祛皱效果评价
选取25～35岁带有眼角纹与眼下纹的女性作为测试者30名，采用应用实施例1-3及应用对比例1-3所制得的面霜常温下室内非避光条件下放置一周后作为测试样品进行祛皱效果测试。使用者每日早晚两次用于整个面部，一次两滴管(每滴管量为0.3-0.5g)，配合防晒(依个人每次使用量约为0.6-0.8g)一起使用(依据使用者面部面积确定用量，使相等面积使用相同含量)。观察使用28天后，细纹淡化效果，结果以10分计，10为有明显的细纹淡化，1为无变化。具体情况如下表7所示：
表7祛皱效果评价表
测试者编号 1 2 3 4 5 6 7 8 9 10 平均值
应用实施例1 8 8 8 9 9 8 9 8 9 9 8.5
应用实施例2 8 8 8 8 9 8 8 8 8 9 8.2
应用实施例3 8 8 9 9 9 8 9 8 8 9 8.5
应用对比例1 7 7 7 7 7 8 7 7 7 7 7.1
应用对比例2 6 6 6 7 6 6 6 6 6 7 6.2
应用对比例3 6 7 7 7 7 7 7 7 7 7 6.9
由表7的祛皱效果评价可以看出，应用实施例1-3所制备的祛皱面霜效果优于应用对比例1-3所制备的祛皱面霜，这是由于应用实施例1-3中的活性物均是视黄醇类包裹物，相较于未被包裹的活性物，保持活性效果更好。这其中应用实施例1与应用实施例3所制的祛皱面霜效果相当，应用对比例1相较于应用对比例3所制的效果更好一些，这可能由于视黄醇棕榈酸酯相较于视黄醇来说，完全分解失效的速度更慢一些。
产业上的可利用性
本公开的提供的视黄醇类包裹物及其制备方法和应用，可以在工业上应用。
本公开的上述实施例仅仅是为清楚地说明本公开所作的举例，而并非是 对本公开的实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。凡在本公开的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本公开权利要求的保护范围之内。

Claims (10)

  1. 一种视黄醇类包裹物，其特征在于，所述视黄醇类包裹物包括以下组分：
    视黄醇类混合油；
    增稠剂；以及
    聚二甲基硅氧烷；其中，
    所述增稠剂包括第一增稠剂、第二增稠剂和第三增稠剂；
    所述视黄醇类混合油与第一增稠剂的质量比为(2-4):1；并且，
    所述第一增稠剂、第二增稠剂以及第三增稠剂可以相同或不同。
  2. 根据权利要求1所述的视黄醇类包裹物，其特征在于，所述视黄醇类混合油与第一增稠剂的混合物、第二增稠剂以及第三增稠剂的质量比为(1-1.4)：(0.05-0.08)：(0.02-0.05)。
  3. 根据权利要求1或2所述的视黄醇类包裹物，其特征在于，所述视黄醇类混合油、第一增稠剂、第二增稠剂以及第三增稠剂形成共混物，所述共混物与所述聚二甲基硅氧烷的质量比为(1-2)：1。
  4. 根据权利要求1-3任一项所述的视黄醇类包裹物，其特征在于，所述视黄醇类混合油包括视黄醇类化合物和聚二甲基硅氧烷；优选地，所述视黄醇类化合物和所述视黄醇类混合油中的聚二甲基硅氧烷的质量比为(1-2)：(1-2)。
  5. 根据权利要求4所述的视黄醇类包裹物，其特征在于，所述视黄醇类化合物包括视黄醇和/或视黄醇酯。
  6. 根据权利要求1-5任一项所述的视黄醇类包裹物，其特征在于，所述增稠剂包括乙烯基聚二甲基硅氧烷/聚甲基硅氧烷硅倍半氧烷交联聚合物、聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物以及丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物中的一种或两种以上的组合。
  7. 一种根据权利要求1-6任一项所述的视黄醇类包裹物的制备方法，其特征在于，包括将所述视黄醇类包裹物的各组分混合的步骤。
  8. 根据权利要求7所述的制备方法，其特征在于，包括以下步骤：
    将视黄醇类混合油与第一增稠剂混合；
    将视黄醇类混合油与第一增稠剂的混合物、第二增稠剂以及第三增稠剂混合，得到共混物；
    将所述共混物分散在聚二甲基硅氧烷中，得到视黄醇类包裹物。
  9. 一种根据权利要求1-6任一项所述的视黄醇类包裹物在护肤品中的应用；优选地，所述护肤品包括化妆水、膏霜、乳液、啫喱或者精华。
  10. 根据权利要求9所述的应用，其特征在于，所述护肤品中，所述视黄醇类包裹物的添加量为1-5％。
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