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WO2021245569A3 - Pharmaceutical composition comprising: a bisabolol compound, valencene and a|terpinene compound - Google Patents

Pharmaceutical composition comprising: a bisabolol compound, valencene and a|terpinene compound Download PDF

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Publication number
WO2021245569A3
WO2021245569A3 PCT/IB2021/054832 IB2021054832W WO2021245569A3 WO 2021245569 A3 WO2021245569 A3 WO 2021245569A3 IB 2021054832 W IB2021054832 W IB 2021054832W WO 2021245569 A3 WO2021245569 A3 WO 2021245569A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
valencene
terpinene
bisabolol
pharmaceutical composition
Prior art date
Application number
PCT/IB2021/054832
Other languages
French (fr)
Other versions
WO2021245569A2 (en
Inventor
Yusef BABIKYAN
Haig BABIKIAN
Benjamin JIARAVANON
Original Assignee
Rhea Genetics Pte. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhea Genetics Pte. Ltd. filed Critical Rhea Genetics Pte. Ltd.
Priority to GB2218187.9A priority Critical patent/GB2611206A/en
Publication of WO2021245569A2 publication Critical patent/WO2021245569A2/en
Publication of WO2021245569A3 publication Critical patent/WO2021245569A3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/01Hydrocarbons
    • A61K31/015Hydrocarbons carbocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432Liposomes or microcapsules
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346Nanoparticles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57449Specifically defined cancers of ovaries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586Liposomes, microcapsules or cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587Nanoparticles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Nanotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

There is disclosed a pharmaceutical composition comprising: a bisabolol compound, valencene and a terpinene compound.
PCT/IB2021/054832 2020-06-02 2021-06-02 A composition WO2021245569A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2218187.9A GB2611206A (en) 2020-06-02 2021-06-02 Pharmaceutical composition comprising: a bisabolol compound, valencene and a terpinene compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2008289.7 2020-06-02
GBGB2008289.7A GB202008289D0 (en) 2020-06-02 2020-06-02 A composition

Publications (2)

Publication Number Publication Date
WO2021245569A2 WO2021245569A2 (en) 2021-12-09
WO2021245569A3 true WO2021245569A3 (en) 2022-02-10

Family

ID=71526250

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2021/054832 WO2021245569A2 (en) 2020-06-02 2021-06-02 A composition

Country Status (2)

Country Link
GB (2) GB202008289D0 (en)
WO (1) WO2021245569A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180352848A1 (en) * 2017-06-07 2018-12-13 NC3 Systems Smokable cannabis-based product with reduced psychoactive effects
US20190240191A1 (en) * 2013-09-18 2019-08-08 The Werc Shop, LLC Terpene-Based Compositions, Processes Methodologies
WO2021011413A1 (en) * 2019-07-12 2021-01-21 Atlas Hemp Company Llc. Methods for isolating essential oils, phytochemicals and pharmaceutically active components from biomass and reconstituting synthetic formulations comprising same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190240191A1 (en) * 2013-09-18 2019-08-08 The Werc Shop, LLC Terpene-Based Compositions, Processes Methodologies
US20180352848A1 (en) * 2017-06-07 2018-12-13 NC3 Systems Smokable cannabis-based product with reduced psychoactive effects
WO2021011413A1 (en) * 2019-07-12 2021-01-21 Atlas Hemp Company Llc. Methods for isolating essential oils, phytochemicals and pharmaceutically active components from biomass and reconstituting synthetic formulations comprising same

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AMBROZ MARTIN ET AL: "The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines", MOLECULES, vol. 22, no. 6, 20 June 2017 (2017-06-20), pages 1021, XP055871072, DOI: 10.3390/molecules22061021 *
ANTHONY J. DE LUCCA ET AL: "Fungicidal and Bactericidal Properties of Bisabolol and Dragosantol", THE JOURNAL OF ESSENTIAL OIL RESEARCH : JEOR, vol. 23, no. 3, 1 May 2011 (2011-05-01), UK, pages 47 - 54, XP055562418, ISSN: 1041-2905, DOI: 10.1080/10412905.2011.9700457 *
BOUSBIA N ET AL: "A new process for extraction of essential oil from Citrus peels: Microwave hydrodiffusion and gravity", JOURNAL OF FOOD ENGINEERING, BARKING ESSEX, GB, vol. 90, no. 3, 1 February 2009 (2009-02-01), pages 409 - 413, XP025425543, ISSN: 0260-8774, [retrieved on 20080703], DOI: 10.1016/J.JFOODENG.2008.06.034 *
DA SILVA JOYCE KELLY R. ET AL: "Essential Oils as Antiviral Agents, Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation", INT. J. MOL. SCI., vol. 21, no. 10, 12 May 2020 (2020-05-12), pages 3426, XP055787017, ISSN: 1661-6596, DOI: 10.3390/ijms21103426 *
GUIMARÃES ALINE CRISTINA ET AL: "Antibacterial Activity of Terpenes and Terpenoids Present in Essential Oils", MOLECULES, vol. 24, no. 13, 5 July 2019 (2019-07-05), pages 2471, XP055836987, DOI: 10.3390/molecules24132471 *
MAATALLAH S ET AL: "Evaluation changing of essential oil of laurel (Laurus nobilisL.) under water deficit stress conditions", INDUSTRIAL CROPS AND PRODUCTS, ELSEVIER, NL, vol. 91, 19 July 2016 (2016-07-19), pages 170 - 178, XP029681348, ISSN: 0926-6690, DOI: 10.1016/J.INDCROP.2016.07.001 *
PERDONES ÁNGELA ET AL: "Effect of chitosan-lemon essential oil coatings on volatile profile of strawberries during storage", FOOD CHEMISTRY, ELSEVIER LTD, NL, vol. 197, 12 November 2015 (2015-11-12), pages 979 - 986, XP029312209, ISSN: 0308-8146, DOI: 10.1016/J.FOODCHEM.2015.11.054 *

Also Published As

Publication number Publication date
WO2021245569A2 (en) 2021-12-09
GB202008289D0 (en) 2020-07-15
GB202218187D0 (en) 2023-01-18
GB2611206A (en) 2023-03-29

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