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WO2020210320A8 - Substituted 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones - Google Patents

Substituted 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones Download PDF

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Publication number
WO2020210320A8
WO2020210320A8 PCT/US2020/027218 US2020027218W WO2020210320A8 WO 2020210320 A8 WO2020210320 A8 WO 2020210320A8 US 2020027218 W US2020027218 W US 2020027218W WO 2020210320 A8 WO2020210320 A8 WO 2020210320A8
Authority
WO
WIPO (PCT)
Prior art keywords
pyrazolo
pyrimidin
dihydro
ones
substituted
Prior art date
Application number
PCT/US2020/027218
Other languages
French (fr)
Other versions
WO2020210320A1 (en
Inventor
Peter Qinhua HUANG
Kevin Duane BUNKER
Brant Clayton Boren
Aditya Krishnan UNNI
Sunny Abraham
Original Assignee
Recurium Ip Holdings, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recurium Ip Holdings, Llc filed Critical Recurium Ip Holdings, Llc
Publication of WO2020210320A1 publication Critical patent/WO2020210320A1/en
Publication of WO2020210320A8 publication Critical patent/WO2020210320A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
PCT/US2020/027218 2019-04-11 2020-04-08 Substituted l,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones WO2020210320A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962832529P 2019-04-11 2019-04-11
US62/832,529 2019-04-11

Publications (2)

Publication Number Publication Date
WO2020210320A1 WO2020210320A1 (en) 2020-10-15
WO2020210320A8 true WO2020210320A8 (en) 2020-11-12

Family

ID=72750610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2020/027218 WO2020210320A1 (en) 2019-04-11 2020-04-08 Substituted l,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones

Country Status (1)

Country Link
WO (1) WO2020210320A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3762385A4 (en) 2018-03-09 2021-11-24 Recurium IP Holdings, LLC Substituted 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones
WO2022221143A1 (en) * 2021-04-12 2022-10-20 Recurium Ip Holdings, Llc Wee1 compound for treating uterine serous carcinoma
CN117751122A (en) * 2021-08-11 2024-03-22 微境生物医药科技(上海)有限公司 1, 2-dihydro-3H-pyrazolo [3,4-d ] pyrimidin-3-one compounds as Wee-1 inhibitors
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR060635A1 (en) * 2006-04-27 2008-07-02 Banyu Pharma Co Ltd DERIVATIVES OF 1,2-DIHIDRO-3H-PIRAZOLO [3,4-D] PIRIMIDIN-3-ONA, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THEIR USE IN THE TREATMENT OF CANCER
WO2009054332A1 (en) * 2007-10-23 2009-04-30 Banyu Pharmaceutical Co., Ltd. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
BR112020002104A2 (en) * 2017-08-01 2020-08-04 Recurium Ip Holdings, Llc 1,2-dihydro-3h-pyrazolo [3,4-d] pyrimidin-3-one analogs
EP3694861A4 (en) * 2017-10-09 2021-05-19 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
EP3762385A4 (en) * 2018-03-09 2021-11-24 Recurium IP Holdings, LLC Substituted 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones

Also Published As

Publication number Publication date
WO2020210320A1 (en) 2020-10-15

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