WO2019178989A1

WO2019178989A1 - 3d-printed artificial vertebral body

Info

Publication number: WO2019178989A1
Application number: PCT/CN2018/096298
Authority: WO
Inventors: 郑明辉; 陈建庭; 瞿东滨; 朱青安; 陆国赞; 朱纬纬
Original assignee: 广州华钛三维材料制造有限公司; 郑明辉
Priority date: 2018-03-23
Filing date: 2018-07-19
Publication date: 2019-09-26
Also published as: CN108354696B; CN108354696A

Abstract

A 3D-printed artificial vertebral body, comprising a first support assembly (10) and a second support assembly (20) connected to the first support assembly. The first support assembly (10) and the second support assembly (20) extend through the upper surface and the lower surface of the 3D printed artificial vertebral body. The first support assembly (10) is disposed on the rear side of the 3D printed artificial vertebral body. The first support assembly (10) is a U-shaped structure curving inwards towards the middle of the 3D printed artificial vertebral body. A gap between the first support assembly (10) and the second support assembly (20) is provided with a filling body composed of a plurality of micropores having a diameter of 0.2-2 mm and a porosity of 60%-80%. The 3D-printed artificial vertebral body has a large adjacent vertebral body contact area, and has a normal vertebral body buffering effect, and the high porosity micropores increase the ingrowth of adjacent vertebral body tissue and cavity implanted bone tissue.

Description

3D printed artificial vertebral body

Technical field

The present invention relates to the field of medical treatment, and more particularly to a 3D printed artificial vertebral body.

Background technique

Patients with severe damage to the vertebral body caused by spinal tumors and severe burst fractures of the spine are mainly treated with total vertebral resection, which can seriously destabilize the biomechanics of the spine. All patients undergoing total vertebral resection It is necessary to reconstruct the stability of the spine, that is, the artificial vertebral body is implanted in the resected vertebral body. The traditional artificial vertebral body is not designed for the individualized patient, and it does not have a buffering effect after being squeezed, and the supporting rigidity is insufficient. , can not achieve a rational therapeutic effect.

Summary of the invention

The object of the present invention is to provide a 3D printed artificial vertebral body, which has high bionicity and conforms to the individualized design of the vertebral body in the human body, and conforms to human anatomy, biomechanics and bone tissue ingrowth, and large adjacent vertebral body contact. The area is used to increase the rigidity required for the vertebral body to undergo extrusion; the normal vertebral body elastic modulus buffering function, and the high porosity micropores increase the ingrowth of the adjacent vertebral body bone tissue and the cavity implanted into the bone tissue, thereby improving the fusion effect.

Its technical solutions are as follows:

The 3D printed artificial vertebral body comprises a first supporting component and a second supporting component connected to the first supporting component, the first supporting component and the second supporting component penetrating the upper surface of the 3D printing artificial vertebral body And a lower surface, the first support component is disposed on a rear side of the 3D printed artificial vertebral body, and the first support component is a U-shaped plate-shaped structure recessed toward a middle of the 3D printed artificial vertebral body, the first a gap between a support component and the second support component is provided with a filler body, the filler body is composed of micropores having a diameter of 0.2 mm to 2 mm, and the filler body also has an upper surface and a lower surface .

The second support assembly includes a first support plate and a second support plate, the first support plate and the second support plate being axially symmetric with respect to a central axis of the 3D printed artificial vertebral body, the first The angle between the support plate and the second support plate in the horizontal direction is 60 degrees to 90 degrees.

A connecting component is disposed between the first supporting component and the second supporting component, and the connecting component is also at least partially penetrated through the upper surface and the lower surface of the 3D printing artificial cone.

The connecting component includes a first connecting plate and a second connecting plate, the first connecting plate and the second connecting plate are at an angle of 60 degrees to 90 degrees with respect to a horizontal direction, the first connecting plate and the a connecting ring is disposed between the second connecting plate and the second supporting component, the connecting ring includes a first connecting ring and a second connecting ring, and the first connecting ring and the second connecting ring are sleeved in the The first support plate, the second support plate, the first connecting plate and the second connecting plate are described.

a cavity is disposed in a middle portion of the filling body, and the cavity is located in the first connecting plate, the second connecting plate, the second supporting component, the first connecting ring and the second connecting ring The cavity is in communication with the microwell.

The connecting component and the second supporting component are both disposed on inner sides of both sides of the U-shaped plate-like structure.

a first nail hole frame and a second nail hole frame are respectively disposed at a middle portion of the two sides of the first support assembly, and the first nail hole frame is connected to the first support plate after the first support frame is connected to the first support plate. The second nail hole frame is connected to the second support plate after the first support assembly, the first nail hole frame is located outside the first connection plate, and the second nail hole frame is located at the An outer side of the second connecting plate, and the first nail hole frame and the second nail hole frame are located between the first connecting ring and the second connecting ring.

The diameter of the nail hole formed on the first supporting component of the first nailing frame and the second nailing frame is 6mm-8mm, and the first nailing frame and the second nailing frame are The angle between the central axis and the horizontal direction is 0 degrees -15 degrees.

An oblique groove is respectively disposed directly under the first nail hole frame and the second nail hole frame, and the inclined groove has a diameter of 3 mm to 5 mm.

The micropores are composed of a tetradecahedron composed of a quadrangle and a hexagon or a dodecahedron composed of a quadrilateral, and the microporosity is 60% to 80%.

The advantages or principles of the present invention are described below:

1. The plate-shaped first support component and the second support component penetrating the 3D printed artificial vertebral body ensure the rigidity of the 3D printed artificial vertebral body, so that the 3D printed artificial vertebral body does not undergo excessive deformation when being squeezed, The filling body composed of micropores has a certain buffering effect when the 3D printed artificial vertebral body is squeezed, so that the 3D printed artificial vertebral body is not damaged due to excessive impact force, and the vertebral body located above the 3D printed artificial vertebral body The bone tissue can enter the 3D printed artificial vertebral body through the micropores on the upper surface of the filling body. The vertebral body tissue located under the 3D printed artificial vertebral body can enter the 3D printing artificial vertebral body through the lower surface of the filling body, thereby increasing the 3D printing artificial body. The interface area between the vertebral body and the adjacent vertebral body, at the same time, the micro-holes on the upper surface and the lower surface of the filling body have a certain anti-slip effect, so that the implanted 3D printed artificial vertebral body does not overlap with the upper and lower vertebral bodies. Due to the shifting and misalignment of the activity,

2. The U-shaped plate-like structure of the first support plate increases the support force of the column in the spine, and the depressed portion thereof avoids pressing the dural sac, the spinal cord and the nerve root, and at the same time, the sides of the U-shaped plate-like structure Increase the stability and support of 3D printed artificial vertebral body. U-shaped plate structure facilitates 3D printing of artificial vertebral body into the human body during operation without damaging the spinal cord, nerve root and surrounding soft tissue.

3. The first support plate and the second support plate which are symmetric and have a certain angle with the horizontal direction increase the rigidity of the 3D printed artificial vertebral body, so that the 3D printed artificial vertebral body does not undergo excessive deformation and breakage due to the extrusion.

4. A connecting component partially connected to the 3D printed artificial vertebral body, which increases the rigidity of the column in the 3D printed artificial vertebral body.

5. The first connecting plate, the second connecting plate, the first connecting ring and the second connecting ring of the connecting component are configured to firmly connect the first supporting component and the second supporting component, and simultaneously make the first supporting component and the second supporting component The space between the spaces is more stable, so that the filler body does not undergo excessive deformation and fracture due to extrusion.

6. The cavity provided by the 3D printed artificial vertebral body can be placed inside the human body bone or allogeneic bone, and the cavity and the micro hole communicate with each other, so that the adjacent vertebral body tissue can pass above the cavity and The micropores in the upper and lower surfaces of the lower and 3D printed artificial vertebral bodies are elongated, which ensures the full fusion of the adjacent vertebral body and the 3D printed artificial vertebral body, and improves the local stability.

7. The first nail hole frame and the second nail hole frame connecting the first support component and the second support component, wherein the pedicle screw can be screwed inside to fix the 3D printed artificial vertebral body and the adjacent vertebral body through the rear connection, At the same time, the first nail holder and the second nail holder make the first support assembly and the second support assembly more securely connected.

8. The first nail hole frame and the second nail hole frame which are obliquely arranged strengthen the stability of the outer side and the rear side of the 3D printed artificial vertebral body.

9. The oblique groove disposed under the first nail hole frame and the second nail hole frame is positioned to conform to the nerve root of the spine, and the size of the inclined groove is designed to avoid passing through the inclined groove. Nerve compression and injury.

DRAWINGS

Figure 1 is a plan view of an embodiment of the present invention;

2 is a schematic perspective view of a three-dimensional structure without a filler body according to an embodiment of the present invention;

Figure 3 is a plan view of Figure 2 of an embodiment of the present invention;

Figure 4 is a rear elevational view of an embodiment of the present invention;

Figure 5 is a cross-sectional view of an embodiment of the present invention.

Description of the reference signs:

10, a first support assembly; 20, a second support assembly; 21, a first support plate; 22, a second support plate; 30, a connection assembly; 31, a first connection plate; 32, a second connection plate; a connecting ring; 34, a second connecting ring; 40, a first nail hole holder; 50, a second nail hole holder; 60, a diagonal groove.

detailed description

The embodiments of the present invention are described in detail below.

As shown in FIG. 1, FIG. 1 is a schematic structural view of an embodiment of the present invention. The embodiment discloses a 3D printed artificial vertebral body for implantation in a human spine. The height of the 3D printed artificial vertebral body in this embodiment is the same as the total height of the lesion or the vertebral body and the upper and lower intervertebral discs in the human body, as shown in FIG. 2 . As shown, the 3D printed artificial vertebral body of the present embodiment includes a first support assembly 10 and a second support assembly 20 connected to the first support assembly 10. The first support assembly 10 and the second support assembly 20 are connected to the 3D printed artificial vertebra. The upper and lower surfaces of the body. The first support component 10 is located on the rear side of the 3D printed artificial vertebral body, and the first support component 10 is a U-shaped plate-shaped structure in which the 3D printed artificial vertebral body is concave in the middle. In the embodiment, the U-shaped plate-shaped structural depression The radius of the part is 12mm-15mm, and the distance between the sides of the U-shaped structure is lesion or damage the width of the vertebral body. The second support assembly 20 includes a first support plate 21 and a second support plate 22. The first support plate 21 and the second support plate 22 are axially symmetric with respect to a central axis of the 3D printed artificial cone, and the first support plate 21 And the angle between the second support plate 22 and the horizontal direction is 60 degrees - 90 degrees.

A connecting component 30 is disposed between the first supporting component 10 and the second supporting component 20, and the connecting component 30 and the second supporting component 20 are both disposed on the inner sides of the U-shaped structure, and the connecting component 30 is also at least partially penetrated by the 3D printing manual. The upper surface and the lower surface of the vertebral body, as shown in FIG. 2, the connecting component 30 includes a first connecting plate 31, a second connecting plate 32 and a connecting ring, and the first connecting plate 31 and the second connecting plate 32 are also opposite to the 3D printing manual. The vertebral bodies are arranged in an axisymmetric manner, and at the same time, the angle between the first connecting plate 31 and the second connecting plate 32 and the horizontal direction is 60 degrees to 90 degrees. The first support plate 21, the second support plate 22, the first connecting plate 31 and the second connecting plate 32 which are disposed obliquely reinforce the stability of the 3D printed artificial vertebral body. As shown in FIG. 1 and FIG. 4 , the connecting ring includes a first connecting ring 33 and a second connecting ring 34 . The first connecting ring 33 and the second connecting ring 34 are sleeved on the first supporting plate 21 and the second supporting plate 22 . The first connecting plate 31 and the second connecting plate 32.

The gap between the first supporting component 10, the second supporting component 20 and the connecting component 30 is provided with a filling body, the filling body is composed of a plurality of micropores, the diameter of the micropores is 0.2 mm-2 mm, and the porosity of the micropores is 60%- 80% quadrilateral and hexagonal tetradecahedron or tetrahedron dodecahedron combined, the filling body also has an upper surface and a lower surface, and the upper surface and the lower surface of the filling body have a certain anti-slip effect. The other side of the filled 3D printed artificial vertebral body opposite to the first supporting component 10 is a curved surface, and the middle portion of the filling body is provided with a cavity, and the cavity is located at the first connecting plate 31, the second connecting plate 32, and the second Between the support assembly 20, the first connecting ring 33 and the second connecting ring 34, the cavity communicates with the micro hole, and the cavity is used for implanting the human body bone or allogeneic bone, and the bone tissue adjacent to the vertebral body can pass The upper and lower sides of the cavity and the micropores grow to increase the fusion rate, and the presence of the micropores increases the interface contact area and the fusion area.

As shown in FIG. 4, in order to fix the connection between the spine after the 3D printing artificial vertebral body implantation, the first nail hole frame 40 and the first part are respectively arranged in the middle of the two sides of the U-shaped plate structure of the first support assembly 10. The second nail holder 50 is connected to the first support plate 21 after the first nail assembly 40 is inserted through the first support assembly 10, and the second nail holder 50 is connected to the second support plate 22 after the first support assembly 10 is inserted. The nail hole frame 40 is located outside the first connecting plate 31, and the second nail hole frame 50 is located outside the second connecting plate 32. As shown in FIG. 5, the first nail frame 40 and the second nail frame 50 are located at the Between the connecting ring 33 and the second connecting ring 34, the first nailing frame 40 and the second nailing frame 50 form a nail hole diameter of 6 mm-8 mm on the first supporting component 10, and the first nailing frame 40 and The angle between the central axis of the second nail holder 50 and the horizontal direction is 0 degrees -15 degrees, and the first nail holder 40 and the second nail holder 50 are respectively coupled to the first support plate 21 and the second support plate 22, respectively. The angle between the two sides of the connected end is 60 degrees - 90 degrees, and the first nail frame 40 and the second nail frame 50 are used to screw the pedicle screw.

In order to reduce or avoid damage to the dura mater, spinal cord or nerve root during 3D printing artificial vertebral body implantation, as shown in FIG. 4, oblique lines are respectively disposed directly under the first nail frame 40 and the second nail hole frame 50. The groove 60 has a nerve root orientation and a size larger than the nerve root size. In the embodiment, the diameter of the oblique groove is 3 mm to 5 mm.

The advantages of this embodiment are as follows:

1. The plate-shaped first support assembly 10 and the second support assembly 20 running through the 3D printed artificial vertebral body ensure the rigidity of the 3D printed artificial vertebral body, so that the 3D printed artificial vertebral body does not undergo excessive deformation when squeezed. The filling body composed of a plurality of micropores has a certain buffering effect when the 3D printed artificial vertebral body is squeezed, so that the 3D printed artificial vertebral body is not damaged due to excessive impact force, and is located above the 3D printed artificial vertebral body. The vertebral body tissue can enter the 3D printed artificial vertebral body through the micropores on the upper surface of the filling body. The vertebral body tissue located under the 3D printed artificial vertebral body can enter the 3D printed artificial vertebral body through the lower surface of the filling body, increasing the 3D. The interface area between the artificial vertebral body and the adjacent vertebral body is printed, and at the same time, the micro-holes on the upper surface and the lower surface of the filling body have a certain anti-slip effect, so that the implanted 3D printed artificial vertebral body is between the upper and lower vertebral bodies. There will be no shifts or misalignments due to activities.

2. The U-shaped plate-like structure of the first support plate 10 increases the supporting force of the column in the spine, and the depressed portion thereof avoids pressing the dural sac, the spinal cord and the nerve root, and at the same time, both sides of the U-shaped plate-like structure While increasing the stability and support of the 3D printed artificial vertebral body, the U-shaped plate structure facilitates the 3D printing of the artificial vertebral body into the human body during operation without damaging the spinal cord, nerve roots and surrounding soft tissues.

3. The symmetry and the first support plate 21 and the second support plate 22 which are disposed at an angle to the horizontal direction increase the rigidity of the 3D printed artificial vertebral body, so that the 3D printed artificial vertebral body does not undergo excessive deformation due to squeezing, fracture.

4. A connection assembly 30 partially connected to the 3D printed artificial vertebral body, which increases the rigidity of the column in the 3D printed artificial vertebral body.

The first connecting plate 31, the second connecting plate 32, the first connecting ring 33 and the second connecting ring 34 of the connecting component 30 enable the first supporting component 10 and the second supporting component 20 to be firmly connected while making the first support The space between the assembly 10 and the second support assembly 20 is more stable, so that the filler body does not undergo excessive deformation and breakage due to extrusion.

7. The first nail frame 40 and the second nail frame 50 connecting the first support assembly 10 and the second support assembly 20, the inside of which can be screwed into the pedicle screw for fixing the 3D printed artificial vertebral body through the rear connection Adjacent to the vertebral body, at the same time, the first nail frame 40 and the second nail frame 50 make the first support assembly 10 and the second support assembly 20 more securely connected.

8. The first nail hole frame 40 and the second nail hole frame 50 disposed obliquely enhance the stability of the outer side and the rear side of the 3D printed artificial vertebral body.

9. The oblique groove 60 disposed under the first nail hole frame 40 and the second nail hole frame 50 is disposed in accordance with the direction of the spinal nerve root, and the size of the inclined groove 60 is designed to avoid the oblique type. The compression and damage of the nerve at the groove 60.

The above is only the specific embodiment of the present invention, and the scope of the present invention is not limited thereto; any substitutions and improvements made without departing from the inventive concept are within the scope of the present invention.

Claims

a 3D printed artificial vertebral body, comprising: a first supporting component and a second supporting component connected to the first supporting component, wherein the first supporting component and the second supporting component penetrate the 3D printing artificial The upper surface and the lower surface of the vertebral body, the first support component is disposed on a rear side of the 3D printed artificial vertebral body, and the first support component is a U-shaped plate recessed toward the middle of the 3D printed artificial vertebral body a structure, a gap between the first support component and the second support component is provided with a filler body, the filler body is composed of micropores, the micropore has a diameter of 0.2 mm to 2 mm, and the filler body also has Upper and lower surfaces.
The 3D printed artificial vertebral body according to claim 1, wherein the second support assembly comprises a first support plate and a second support plate, and the first support plate and the second support plate are opposite to the second support plate The central axis of the 3D printed artificial vertebral body is arranged in an axisymmetric manner, and the angle between the first support plate and the second support plate and the horizontal direction is 60 degrees to 90 degrees.
The 3D printed artificial vertebral body according to claim 2, wherein a connection component is disposed between the first support component and the second support component, and the connection component is also at least partially penetrated by the 3D printing. The upper surface and the lower surface of the artificial vertebral body.
The 3D printed artificial vertebral body according to claim 3, wherein the connecting component comprises a first connecting plate and a second connecting plate, and the first connecting plate and the second connecting plate are horizontally clamped a connecting ring is disposed between the first connecting plate and the second connecting plate and the second supporting component, and the connecting ring includes a first connecting ring and a second connecting ring, where the angle is between 60 degrees and 90 degrees. The first connecting ring and the second connecting ring are sleeved on the first supporting plate, the second supporting plate, the first connecting plate and the second connecting plate.
The 3D printed artificial vertebral body according to claim 4, wherein a central portion of the filling body is provided with a cavity, and the cavity is located at the first connecting plate, the second connecting plate, and the second Between the support assembly, the first connecting ring and the second connecting ring, the cavity is in communication with the micro hole.
The 3D printed artificial vertebral body according to claim 5, wherein the connecting component and the second supporting component are both disposed on inner sides of both sides of the U-shaped plate-like structure.
The 3D printed artificial vertebral body according to claim 6, wherein a first nail hole frame and a second nail hole frame are respectively disposed at a middle portion of the two sides of the first support component, and the first nail hole frame runs through The first supporting component is connected to the first supporting plate, and the second nailing frame is connected to the second supporting plate after the first supporting component, the first nailing frame is located at the An outer side of the first connecting plate, the second nail hole frame is located outside the second connecting plate, and the first nail hole frame and the second nail hole frame are located at the first connecting ring and the first Between the two connecting rings.
The 3D printed artificial vertebral body according to claim 7, wherein the first nail holder and the second nail holder form a nail hole having a diameter of 6 mm to 8 mm on the first support assembly. The angle between the central axis of the first nail holder and the second nail holder and the horizontal direction is 0 degrees -15 degrees.
The 3D printed artificial vertebral body according to claim 7 or claim 8, wherein the first nail hole frame and the second nail hole frame are respectively provided with oblique grooves directly under the second nail hole frame, and the oblique The groove has a diameter of 3 mm to 5 mm.
The 3D printed artificial vertebral body according to claim 9, wherein the micropores are composed of a tetradecahedron composed of a quadrangle and a hexagon or a dodecahedron composed of a quadrilateral, the microporous pore. The rate is 60%-80%.