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WO2018115509A3 - New flavivirus vaccine - Google Patents

New flavivirus vaccine Download PDF

Info

Publication number
WO2018115509A3
WO2018115509A3 PCT/EP2017/084527 EP2017084527W WO2018115509A3 WO 2018115509 A3 WO2018115509 A3 WO 2018115509A3 EP 2017084527 W EP2017084527 W EP 2017084527W WO 2018115509 A3 WO2018115509 A3 WO 2018115509A3
Authority
WO
WIPO (PCT)
Prior art keywords
subunits
diagnosis
infection
flavivirus
zika virus
Prior art date
Application number
PCT/EP2017/084527
Other languages
French (fr)
Other versions
WO2018115509A2 (en
Inventor
Willem Adriaan DE JONGH
Teit Max Moscote SØGAARD
Thomas Dan JØRGENSEN
Original Assignee
Expres2Ion Biotechnologies Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Expres2Ion Biotechnologies Aps filed Critical Expres2Ion Biotechnologies Aps
Priority to EP17832235.0A priority Critical patent/EP3558353A2/en
Priority to US16/472,414 priority patent/US20190358313A1/en
Publication of WO2018115509A2 publication Critical patent/WO2018115509A2/en
Publication of WO2018115509A3 publication Critical patent/WO2018115509A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/18—Togaviridae; Flaviviridae
    • C07K14/1816—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus), border disease virus
    • C07K14/1825—Flaviviruses or Group B arboviruses, e.g. yellow fever virus, japanese encephalitis, tick-borne encephalitis, dengue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to polypeptides suitable for protection against and diagnosis of the conditions caused by flavivirus infections. More specifically, the invention concerns subunits of the zika virus envelope glycoprotein E secreted as mature recombinantly produced proteins from eucaryotic cells, such as from insect cells. Additional viral proteins or subunits, also produced in this way, provide additional active ingredients. These protein subunits, alone or in combination including combination with additional viral-derived peptides are protective against infection by flavivirus, such as zika virus, raise antibodies useful in immunization, and are useful in diagnosis of infection by the virus.
PCT/EP2017/084527 2016-12-23 2017-12-22 New flavivirus vaccine WO2018115509A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP17832235.0A EP3558353A2 (en) 2016-12-23 2017-12-22 New flavivirus vaccine
US16/472,414 US20190358313A1 (en) 2016-12-23 2017-12-22 New flavivirus vaccine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16206717.7 2016-12-23
EP16206717 2016-12-23

Publications (2)

Publication Number Publication Date
WO2018115509A2 WO2018115509A2 (en) 2018-06-28
WO2018115509A3 true WO2018115509A3 (en) 2018-08-30

Family

ID=57737597

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2017/084527 WO2018115509A2 (en) 2016-12-23 2017-12-22 New flavivirus vaccine

Country Status (3)

Country Link
US (1) US20190358313A1 (en)
EP (1) EP3558353A2 (en)
WO (1) WO2018115509A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112921124B (en) * 2021-04-08 2021-09-28 广东创晟控股集团有限公司 Kit for rapidly detecting viruses

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019090228A2 (en) 2017-11-03 2019-05-09 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
CN111601885B (en) 2017-11-30 2025-01-07 武田疫苗股份有限公司 Methods for inactivating Zika virus and related methods
KR101966841B1 (en) 2018-12-12 2019-04-08 대한민국 Recombinant antigen derived from zika virus e protein and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080268423A1 (en) * 2002-08-16 2008-10-30 Alan Barrett Compositions and Methods Related to Flavivirus Envelope Protein Domain III Antigens
WO2008152528A2 (en) * 2007-06-15 2008-12-18 Institut Pasteur Method for the diagnosis or the screening of an arbovirus infection, reagents useful in said method and their applications
WO2016012800A1 (en) * 2014-07-23 2016-01-28 Imperial Innovations Limited Anti-dengue vaccines and antibodies
WO2018064558A1 (en) * 2016-09-30 2018-04-05 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Zika virus vaccines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080268423A1 (en) * 2002-08-16 2008-10-30 Alan Barrett Compositions and Methods Related to Flavivirus Envelope Protein Domain III Antigens
WO2008152528A2 (en) * 2007-06-15 2008-12-18 Institut Pasteur Method for the diagnosis or the screening of an arbovirus infection, reagents useful in said method and their applications
WO2016012800A1 (en) * 2014-07-23 2016-01-28 Imperial Innovations Limited Anti-dengue vaccines and antibodies
WO2018064558A1 (en) * 2016-09-30 2018-04-05 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Zika virus vaccines

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE UniProt [online] 1 April 1988 (1988-04-01), "RecName: Full=Genome polyprotein; Contains: RecName: Full=Capsid protein C; AltName: Full=Core protein; Contains: RecName: Full=Protein prM; Contains:", XP002781449, retrieved from EBI accession no. UNIPROT:P07564 Database accession no. P07564 *
DATABASE UniProt [online] 16 March 2016 (2016-03-16), "RecName: Full=Genome polyprotein {ECO:0000256|SAAS:SAAS00368684};", XP002781450, retrieved from EBI accession no. UNIPROT:A0A0U4DG08 Database accession no. A0A0U4DG08 *
GIOVANNA BARBA-SPAETH ET AL: "Structural basis of potent Zika-dengue virus antibody cross-neutralization", NATURE, vol. 536, no. 7614, 23 June 2016 (2016-06-23), GB, pages 48 - 53, XP055328133, ISSN: 0028-0836, DOI: 10.1038/nature18938 *
HEINZ F X ET AL: "Recombinant and virion-derived soluble and particulate immunogens for vaccination against tick-borne encephalitis", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 13, no. 17, 1 December 1995 (1995-12-01), pages 1636 - 1642, XP004057391, ISSN: 0264-410X, DOI: 10.1016/0264-410X(95)00133-L *
LEDIZET M ET AL: "A recombinant envelope protein vaccine against West Nile virus", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 23, no. 30, 10 June 2005 (2005-06-10), pages 3915 - 3924, XP027652297, ISSN: 0264-410X, [retrieved on 20050610] *
LIANPAN DAI ET AL: "Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody", CELL HOST & MICROBE, vol. 19, no. 5, 1 May 2016 (2016-05-01), NL, pages 696 - 704, XP055352074, ISSN: 1931-3128, DOI: 10.1016/j.chom.2016.04.013 *
STAROPOLI I ET AL: "Affinity-purified dengue-2 virus envelope glycoprotein induces neutralizing antibodies and protective immunity in mice", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 15, no. 17-18, 1 December 1997 (1997-12-01), pages 1946 - 1954, XP004097390, ISSN: 0264-410X, DOI: 10.1016/S0264-410X(97)00128-X *
TROVATO MARIA ET AL: "E2 multimeric scaffold for vaccine formulation: immune response by intranasal delivery and transcriptome profile of E2-pulsed dendritic cells", BMC MICROBIOLOGY, vol. 16, July 2016 (2016-07-01), XP009505697 *
WANG S ET AL: "PrM- and cell-binding domains of the dengue virus E protein", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 73, no. 3, 1 March 1999 (1999-03-01), pages 2547 - 2551, XP002405616, ISSN: 0022-538X *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112921124B (en) * 2021-04-08 2021-09-28 广东创晟控股集团有限公司 Kit for rapidly detecting viruses

Also Published As

Publication number Publication date
WO2018115509A2 (en) 2018-06-28
US20190358313A1 (en) 2019-11-28
EP3558353A2 (en) 2019-10-30

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