WO2018183516A1

WO2018183516A1 - Removable oral devices and their use in combination with therapeutics, implants and other devices

Info

Publication number: WO2018183516A1
Application number: PCT/US2018/024867
Authority: WO
Inventors: William H. Longley; Richard P. Schneider; Anthony R. Tremaglio; Marc M. GIBELEY
Original assignee: Scientific Intake Limited Co.
Priority date: 2017-03-28
Filing date: 2018-03-28
Publication date: 2018-10-04

Abstract

Certain configurations are described herein which comprise a removable oral device in combination with one or more of a pharmacological agent, a biological agent, a medical device or medical procedure. The combination of the removable oral device and the pharmacological agent, medical device or medical procedure can be used, for example, to treat obesity, diabetes, high blood pressure, high cholesterol, joint disorders, hyperlipidemia, reduce weight, control weight, reduce blood pressure, increase arterial or venous blood flow or to treat other conditions.

Description

REMOVABLE ORAL DEVICES AND THEIR USE IN COMBINATION WITH

THERAPEUTICS, IMPLANTS AND OTHER DEVICES

[0001] PRIORITY APPLICATIONS

[0002] This application claims priority to and the benefit of US 62/477,768 filed on March 28, 2017 and entitled "REMOVABLE ORAL DEVICES AND THEIR USE IN COMBINATION WITH PHARMACOLOGICAL AGENTS, IMPLANTS AND OTHER DEVICES" and claims priority to U.S. Provisional Application No. 62/521,498 filed on June 18, 2017 and entitled "METHODS OF USING REMOVABLE ORAL DEVICES." The entire disclosure of each of these applications is hereby incorporated herein by reference for all purposes.

[0003] CROSS-REFERENCE TO RELATED APPLICATIONS

[0004] This application is related to, and incorporates by reference herein, each of the following patent applications: U.S. Provisional Application 62/477,752 filed on March 28, 2017 and entitled "REMOVABLE ORAL DEVICES," U.S. Provisional Application No. 62/477,760 filed on March 28, 2017 and entitled "METHODS OF USING REMOVABLE ORAL DEVICES," U.S. Provisional Application No. 62/477,764 filed on March 28, 2017 and entitled "METHODS OF PRODUCING REMOVABLE ORAL DEVICES," and U.S. Provisional Application No. 62/477,766 filed on March 28, 2017 and entitled "SYSTEMS INCLUDING REMOVABLE ORAL DEVICES."

[0005] TECHNOLOGICAL FIELD

[0006] This application is directed to removable oral devices and their use in combination with therapeutics, implants and other devices. More particularly, certain embodiments described herein are directed to removable oral devices which can reduce the volume of the mouth and their use in combination with weight loss drugs, diabetes drugs, biological materials, bariatric methods, and other devices and systems.

[0007] BACKGROUND

[0008] Devices to enhance weight loss and weight control weight exist. Most existing devices and methods do not provide long term weight loss or health benefits.

[0009] SUMMARY

[0010] Certain illustrative configurations are directed to removable oral devices which can be used in combination with one or more other materials or devices. As noted in more detail below, in certain configurations the removable oral devices are not configured to move the teeth, correct tongue thrust issues, sleep apnea issues, etc. The removable oral devices can be present in a kit or combination with one or more therapeutics, weight loss devices, drugs, implants, or other materials or devices. For example, the removable oral devices can be used in combination with other materials or devices to treat one or more conditions which may be caused or linked, at least in part, to a mammalian subject being overweight, obese or even morbidly obese.

[0011] In one aspect, a system or kit comprises a removable oral device comprising a palatal element coupled to a clasping element, the palatal element configured to engage a roof of a user's mouth and reduce an oral volume of the mouth during chewing of food, the clasping element configured to assist in removal of the removable oral device from the user's mouth, and a pharmacological agent

[0012] In some examples, the pharmacological agent is a weight loss drug, e.g., a stimulant or other weight loss drug as described herein. In certain examples, the pharmacological agent is a diabetes drug, e.g, comprises an insulin or other diabetes drug as described herein. In certain embodiments, the pharmacological agent is a high blood pressure drug, e.g., a diuretic, beta blocker or an acetylcholinesterase inhibitor. In some instances, the pharmacological agent is a cholesterol or lipd lowering drug, e.g., a statin or other cholesterol or lipd lowering drug described herein. In some examples, the pharmacological agent comprises a biological agent, e.g., an antibody, peptide or other biological agents described herein. In some examples, the pharmacological agent comprises at least two different pharmacological agents.

[0013] In another aspect, a system or kit comprises a removable oral device comprising a palatal element configured to engage the roof of a user's mouth and reduce an oral volume of the mouth during chewing of food. The removable oral device may also comprise a clasping element configured to assist in removal of the removable oral device from the mouth.

[0014] In an additional aspect, the system or kit further comprises an endoscopic balloon.

[0015] In another aspect, the system or kit further comprises a swallowable balloon, e.g., a swallowable balloon which can degrade or reduce its volume over time.

[0016] In an additional aspect, the system or kit further comprises any space occupying (permanent or temporary) device anywhere in the gastrointestinal (GI) tract", e.g., Gelusil. In other aspect, the system or kit comprises any device in the GI tract that blocks or modifies absorption anywhere is the GI tract.

[0017] In another aspect, the system or kit further comprises a swallowable pill or tablet, e.g., an expandable pill that fills the stomach volume like a balloon and degrade over time.

[0018] In an additional aspect, the system or kit further comprises a gastric band or an endoscopic endoluminal bypass device, e.g., EndoBarrier or the like. [0019] In some examples, the removable oral device can be used in combination with surgical endoluminal bypass procedures, e.g., Fractyl or the like.

[0020] In another aspect, the system or kit further comprises an electrical stimulation system configured to provide a stimulus to induce a sensation of fullness in a stomach of the human.

[0021] In an additional aspect, the system or kit further comprises a gastric emptying system configured to reduce absorption of the chewed food in the stomach.

[0022] In another aspect, the system or kit further comprises instructions for using the removable oral device with a surgical method configured to reduce stomach volume.

[0023] In an additional aspect, the system or kit further comprises instructions for using the removable oral device with a stent to increase arterial or venous blood flow in the human.

[0024] In another aspect, the system or kit further comprises instructions for using the removable oral device with an angioplasty procedure to increase arterial or venous blood flow in the human.

[0025] In an additional aspect, the system or kit further comprises instructions for using the removable oral device with an implant to treat a joint disorder of the human.

[0026] In another aspect, the system or kit further comprises instructions for using the removable oral device with an implant to treat a joint disorder of the human.

[0027] In an additional aspect, the system or kit further comprises a weight loss drug.

[0028] In another aspect, the system or kit further comprises a diabetes drug.

[0029] In an additional aspect, the system or kit further comprises a high blood pressure drug.

[0030] In another aspect, the system or kit further comprises a cholesterol or lipid lowering drug.

[0031] In an additional aspect, the system or kit further comprise at least two different therapeutic agents selected from the pharmacological agents and biological agents described herein.

[0032] In another aspect, the system or kit further comprises a pharmacological agent comprising a bar code present on a surface of the material.

[0033] In an additional aspect, the system or kit comprises a pharmacological agent comprising a radio frequency tag.

[0034] In another aspect, the system or kit further comprises a pharmacological agent comprising a colorant.

[0035] In an additional aspect, a method of treating high cholesterol comprises providing a removable oral device as described herein and providing at least one cholesterol or lipid lowering drug.

[0036] In another aspect, a method of treating high cholesterol comprises providing a removable oral device as described herein and providing at least one diabetic drug. [0037] In an additional aspect, a method of treating high cholesterol comprises providing a removable oral device as described herein and providing at least one weight loss drug.

[0038] In another aspect, a method of treating high cholesterol comprises providing a removable oral device as described herein and providing at least one biological agent.

[0039] Additional aspects, examples, embodiments and configurations are described further below.

[0040] BRIEF DESCRIPTION OF THE SEVERAL VIEW OF THE DRAWINGS

[0041] Certain configurations of removable oral devices and their use in combination with other materials or devices are described below with reference to the accompanying figures in which:

[0042] FIG. 1 is an illustration of a removable oral device, in accordance with certain examples.

[0043] DETAILED DESCRIPTION

[0044] Various materials and components are described as being used in combination with one or more removable oral devices to treat one or more medical conditions in a mammal such as a human. The exact amount of the drug or other material used in combination with the removable oral device may vary with user weight, may decrease over time or can otherwise be altered or changed during treatment. Various configurations of removable oral devices are described in commonly assigned application bearing attorney docket no. SCIINTAK-700100 filed on even date herewith. As noted therein, the removable oral device is generally not configured to alter a position of the teeth or retain a position of the teeth during use of the removable oral device.

[0045] In certain configurations, the removable oral device can be used in combination with one or more medical devices or implants. For example, a removable oral device can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon.

[0046] In other configurations, a removable oral device can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon.

[0047] In certain examples, a removable oral device can be used in combination with other medical devices such as an endoscopic endoluminal sleeve, an electrical stimulation system, a gastric band, a gastric emptying system, a CPAP, an implant, e.g., knee, hip, ankle, etc., a stent or other angioplasty devices. In some instances, a removable oral device can be used pre- operatively and/or post-operatively with one or more surgical methods or techniques including, but not limited to, gastric bypass surgery, sleeve gastrectomy, bilio pancreatic diversion w/duodenal switch and/or open heart and percutaneous surgery. The removable oral device may be particularly desirable for use in weight management/loss applications in combination with one or more of liposuction, fat freezing, laser treatments and Roux-en-Y procedures.

[0048] In other configurations, a removable oral device can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. In some examples, a removable oral device can be used in combination with one or more diabetes drugs used to assist in the treatment of diabetes. In some instances, a removable oral device can be used in combination with one or more high blood pressure drugs. In some examples, a removable oral device can be used in combination with one or more cholesterol or lipid lowering drugs. In certain examples, a removable oral device can be used in combination with one or more biological agent such as a monoclonal antibody, for example.

[0049] Various configurations of a removable oral device are described in the commonly assigned patent applications incorporated herein by reference. For illustration purposes, one illustration of a removable oral device is shown in FIG. 1. The removable oral device 100 comprises a palatal element 110 and optional clasping elements 120, 122. A noted herein, the clasping element can be designed to assist in removal of the removable oral device from the mouth. The removable oral device 100 may comprise an optional on-board component 130, which can take various forms including sensors, an electrode, etc. Numerous other configurations of removable oral devices are described below and in the patent applications referenced herein.

[0050] Certain illustrative combinations of removable oral devices and other devices or materials are described in more detail below.

[0051] Combinations Comprising Removable Oral Devices with a Variable Hardness

[0052] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device which comprises a body comprising a variable hardness across a tongue surface. For example, the removable oral device may comprise a palatal element coupled to a clasping element, in which the palatal element is configured to contact the roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. The body comprises a variable hardness across a tongue surface of the body. The clasping element is configured to assist in removal of the removable oral device from the mouth.

[0053] Such removable oral devices with variable hardness can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with the variable hardness can be used in combination with one or more medical devices or implants. For example, a removable oral device with a variable hardness can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with removable oral device comprising a variable hardness.

[0054] In other configurations, a removable oral device comprising a variable hardness can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with a variable hardness in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device comprising a variable hardness.

[0055] In some configurations, the removable oral device comprising a variable hardness can be used with other medical devices. For example, removable oral device comprising a variable hardness can be used with an endoscopic endoluminal sleeve such as EndoBarrier sleeve. A removable oral device comprising a variable hardness can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device comprising a variable hardness can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device comprising a variable hardness can be used with a gastric emptying system such as the Aspire assist system. A removable oral device comprising a variable hardness can be used with a CPAP device. A removable oral device comprising a variable hardness can be used with a knee implant. A removable oral device comprising a variable hardness can be used with a hip implant. A removable oral device comprising a variable hardness can be used with an ankle implant. A removable oral device comprising a variable hardness can be used with a spinal implant, e.g., a neck or back implant. A removable oral device comprising a variable hardness can be used with a coronary, venous or arterial stent. A removable oral device comprising a variable hardness can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device comprising a variable hardness.

[0056] In other configurations, a removable oral device with a variable hardness can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device comprising a variable hardness can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device comprising a variable hardness can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device comprising a variable hardness can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device comprising a variable hardness.

[0057] In other configurations, a removable oral device comprising a variable hardness can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device comprising a variable hardness is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a variable hardness can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device comprising a variable hardness can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device comprising a variable hardness can be used with a naltrexone hydrochloride and bupropion hydrochloride extended-release tablet such as the drug commercially marketed as Contrave. A removable oral device comprising a variable hardness can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide-1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device comprising a variable hardness can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device comprising a variable hardness can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device comprising a variable hardness can be used with a lorcaserin HC1 such as the drug commercially marketed as Belviq.

A removable oral device comprising a variable hardness can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device comprising a variable hardness can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device comprising a variable hardness can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device comprising a variable hardness can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device comprising a variable hardness can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device comprising a variable hardness can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device comprising a variable hardness can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device comprising a variable hardness can be used with any two or more of the weight loss drugs listed herein.

[0058] In some examples, a removable oral device comprising a variable hardness can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with variable hardness is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a variable hardness can be used with short acting insulin (Humulin and novolin). A removable oral device comprising a variable hardness can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device comprising a variable hardness can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device comprising a variable hardness can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device comprising a variable hardness can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device comprising a variable hardness can be used with a somatostatin. A removable oral device comprising a variable hardness can be used with a diazoxide. A removable oral device comprising a variable hardness can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device comprising a variable hardness can be used with a dopamine agonist such as bromocriptine. A removable oral device comprising a variable hardness can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[0059] In some instances, a removable oral device comprising a variable hardness can be used with glucagon like peptides. For example, a removable oral device comprising a variable hardness can be used with albiglutide (Tanzeum). A removable oral device comprising a variable hardness can be used with dulaglutide (Trulicity). A removable oral device comprising a variable hardness can be used with exenetide (Byetta). A removable oral device comprising a variable hardness can be used with exenatide extended release (Bydureon). A removable oral device comprising a variable hardness can be used with liraglutide (Victoza). A removable oral device comprising a variable hardness can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[0060] In certain examples, a removable oral device comprising a variable hardness can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device comprising a variable hardness can be used with dapagliflozin (Farxiga). A removable oral device comprising a variable hardness can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device comprising a variable hardness can be used with carnagliflozin (Invokana). A removable oral device comprising a variable hardness can be used with canagliflozin-metformin (Invokamet). A removable oral device comprising a variable hardness can be used with empagliflozin (Jardiance). A removable oral device comprising a variable hardness can be used with empagliflozin-linagliptin (Glyxambi).

[0061] In other examples, a removable oral device comprising a variable hardness can be used with a sulfonylurea. For example, a removable oral device comprising a variable hardness can be used with glimepiride (Amaryl). A removable oral device comprising a variable hardness can be used with glimepride-pioglitazone (Duotact). A removable oral device comprising a variable hardness can be used with glimepiride-rosiglitazone (Avendary). A removable oral device comprising a variable hardness can be used with gliclazide, glipizide (Glucotrol). A removable oral device comprising a variable hardness can be used with glipizide-metformin (Metaglip). A removable oral device comprising a variable hardness can be used with glyburide (Diabets, glynase, Micronase). A removable oral device comprising a variable hardness can be used with chloropropamide (Diabinese). A removable oral device comprising a variable hardness can be used with tolazamide (Tolinase). A removable oral device comprising a variable hardness can be used with tolbutamide (Orinase, tol-tab).

[0062] In some instances, a removable oral device comprising a variable hardness can be used with a thiazolidinedione. For example, a removable oral device comprising a variable hardness can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device comprising a variable hardness can be used with rosiglitazone-metformin (Amaryl M). A removable oral device comprising a variable hardness can be used with pioglitazone (Actos). A removable oral device comprising a variable hardness can be used with pioglitazone- alogliptin (Oseni). A removable oral device comprising a variable hardness can be used with pilglitazone-glimepride (Duetact). A removable oral device comprising a variable hardness can be used with pioglitazone-metformin (Actoplus met, Actoplus met xr). A removable oral device comprising a variable hardness can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device comprising a variable hardness can be used with a glucagon. If desired, a removable oral device comprising a variable hardness can be used with any two, three or more of the diabetes drugs listed herein.

[0063] In some instances, a removable oral device a variable hardness can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device a variable hardness is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device a variable hardness with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[0064] In certain examples, a removable oral device comprising a variable hardness can be used with a diuretic. For example, a removable oral device comprising a variable hardness can be used with chlorthalidone (Hygroton). A removable oral device comprising a variable hardness can be used with chlorothiazide (Diruil). A removable oral device comprising a variable hardness can be used with furosemide (Lasix). A removable oral device comprising a variable hardness can be used with hydrochlorothiazide (Esidrix). A removable oral device comprising a variable hardness can be used with indapamide (Lozol). A removable oral device comprising a variable hardness can be used with metolazone (Mykrox).

[0065] In certain instances, a removable oral device comprising a variable hardness can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device comprising a variable hardness can be used with combination diuretics. For example, A removable oral device comprising a variable hardness can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device comprising a variable hardness can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device comprising a variable hardness can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[0066] In some instances, a removable oral device comprising a variable hardness can be used with a beta blocker. For example, A removable oral device comprising a variable hardness can be used with acebutolol (Sectral). A removable oral device comprising a variable hardness can be used with atenolol (Tenormin). A removable oral device comprising a variable hardness can be used with betaxolol (Kerlone). A removable oral device comprising a variable hardness can be used with bisoprolol fumarate (Zebeta). A removable oral device comprising a variable hardness can be used with cartelol hydrochloride (Cartrol). A removable oral device comprising a variable hardness can be used with metoprolol tartrate (Lopressor). A removable oral device comprising a variable hardness can be used with metoprolol succinate (Toprol-XL). A removable oral device comprising a variable hardness can be used with nadolol (Corgard). A removable oral device comprising a variable hardness can be used with penbutolol sulfate (Levatol). A removable oral device comprising a variable hardness can be used with pindolol (Visken). A removable oral device comprising a variable hardness can be used with propanolol hydrochloride (Inderal). A removable oral device comprising a variable hardness can be used with solotolol hydrochloride (Betapace). A removable oral device comprising a variable hardness can be used with timolol maleate (Blocadren). A removable oral device comprising a variable hardness can be used with, nebivolol (Bystoliv). A removable oral device comprising a variable hardness can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[0067] In some examples, a removable oral device comprising a variable hardness can be used with an acetylcholinesterase inhibitor. For example, a removable oral device comprising a variable hardness can be used with benaxepril hydrochloride (Lotensin). A removable oral device comprising a variable hardness can be used with captopril (Capoten). A removable oral device comprising a variable hardness can be used with enalpril maleate (Vasotec). A removable oral device comprising a variable hardness can be used with fosinopril sodium (Monopril) A removable oral device comprising a variable hardness can be used with lisonopril (Prinivel, Zestril). A removable oral device comprising a variable hardness can be used with moexipril (Univasc). A removable oral device comprising a variable hardness can be used with perindopril (Aceon). A removable oral device comprising a variable hardness can be used with quinapril hydrochloride (Accupril). A removable oral device comprising a variable hardness can be used with ramipril (Altace). A removable oral device comprising a variable hardness can be used with trandolapril (Mavik).

[0068] In certain examples, a removable oral device comprising a variable hardness can be used with an angiotensin II receptor blocker. For example, a removable oral device comprising a variable hardness can be used with candesartan (Atacand). A removable oral device comprising a variable hardness can be used with eprosartan mesylate (Teveten). A removable oral device comprising a variable hardness can be used with irbesartan (Avapro). A removable oral device comprising a variable hardness can be used with losartan potassium (Cozaar). A removable oral device comprising a variable hardness can be used with telmisartan (Micardis). A removable oral device comprising a variable hardness can be used with valsartan (Diovan).

[0069] In certain embodiments, a removable oral device comprising a variable hardness can be used with a calcium channel blocker. For example, a removable oral device comprising a variable hardness can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device comprising a variable hardness can be used with bepridil (Vasocor). A removable oral device comprising a variable hardness can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device comprising a variable hardness can be used with felodipine (Plendil). A removable oral device comprising a variable hardness can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device comprising a variable hardness can be used with nicardipine (Cardene SR). A removable oral device comprising a variable hardness can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device comprising a variable hardness can be used with nisoldipine (Sular). A removable oral device comprising a variable hardness can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[0070] In certain embodiments, a removable oral device comprising a variable hardness can be used with an alpha blocker. For example, a removable oral device comprising a variable hardness can be used with doxazosin mesylate (Cardura). A removable oral device comprising a variable hardness can be used with prazosin hydrochloride (Minipress). A removable oral device comprising a variable hardness can be used with terazosin hydrochloride (Hytrin).

[0071] In certain embodiments, a removable oral device comprising a variable hardness can be used with an alpha-2-receptor agonist. For example, a removable oral device comprising a variable hardness can be used with methyldopa.

[0072] In certain embodiments, a removable oral device comprising a variable hardness can be used with combined alpha and beta blockers. For example, a removable oral device comprising a variable hardness can be used with carvedilol (Coreg). A removable oral device comprising a variable hardness can be used with labetalol hydrochloride (Normodyne, Trandate).

[0073] In certain embodiments, a removable oral device comprising a variable hardness can be used with a central agonist. For example, a removable oral device comprising a variable hardness can be used with alpha methyldopa (Aldomet). A removable oral device comprising a variable hardness can be used with clonidine hydrochloride (Catapres). A removable oral device comprising a variable hardness can be used with guanabenz acetate (Wytensin). A removable oral device comprising a variable hardness can be used with guanfacine hydrochloride (Tenex).

[0074] In certain embodiments, a removable oral device comprising a variable hardness can be used with a peripheral adrenergic inhibitor. For example, a removable oral device comprising a variable hardness can be used with guanadrel (Hylorel). A removable oral device comprising a variable hardness can be used with guanethidine monosulfate (Ismelin). A removable oral device comprising a variable hardness can be used with reserpine (Serpasil).

[0075] In certain embodiments, a removable oral device comprising a variable hardness can be used with a blood vessel dilator (vasodilator). For example, a removable oral device comprising a variable hardness can be used with hydralazine hydrocholoride (Apresoline). A removable oral device comprising a variable hardness can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device comprising a variable hardness.

[0076] In some examples, a removable oral device comprising a variable hardness can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device comprising a variable hardness is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising a variable hardness with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[0077] In certain examples, a removable oral device comprising a variable hardness can be used with a statin. For example, a removable oral device comprising a variable hardness can be used with an atorvastatin (Lipitor). A removable oral device comprising a variable hardness can be used with a fluvastatin (Lescol). A removable oral device comprising a variable hardness can be used with a rosuvastatin (Crestor). A removable oral device comprising a variable hardness can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device comprising a variable hardness.

[0078] In certain examples, a removable oral device comprising a variable hardness can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device comprising a variable hardness can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device comprising a variable hardness. [0079] In certain examples, a removable oral device comprising a variable hardness can be used with a resin (bile-acid binding drugs). For example, a removable oral device comprising a variable hardness can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device comprising a variable hardness can be used with colestipol (Colestid®). A removable oral device comprising a variable hardness can be used with colesevelam HC1 (WelChol®). If desired, two or more of resins can be used in combination with removable oral device comprising a variable hardness.

[0080] In some examples, a removable oral device comprising a variable hardness can be used with lipid lowering therapies. For example, a removable oral device comprising a variable hardness can be used with gemfibrozil (Lopid®). A removable oral device comprising a variable hardness can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device comprising a variable hardness can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device comprising a variable hardness.

[0081] In some examples, a removable oral device comprising a variable hardness can be used with one or more biological agents, which are species of pharmacological agents, such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device comprising a variable hardness can provide both short term and long term treatment. In some examples, a removable oral device comprising a variable hardness can be used with Abatacept (Orencia). A removable oral device comprising a variable hardness can be used with Adalimumab (Humira). A removable oral device comprising a variable hardness can be used with Adalimumab -atto (Amjevita), a biosimilar to Humira. A removable oral device comprising a variable hardness can be used with Anakinra (Kineret). A removable oral device comprising a variable hardness can be used with Certolizumab pegol (Cimzia). A removable oral device comprising a variable hardness can be used with Etanercept (Enbrel). A removable oral device comprising a variable hardness can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device comprising a variable hardness can be used with Golimumab (Simponi, Simponi Aria). A removable oral device comprising a variable hardness can be used with Infliximab (Remicade). A removable oral device comprising a variable hardness can be used with Infliximab-dyyb (Inflectra), a biosimilar to Remicade. A removable oral device comprising a variable hardness can be used with Rituximab (Rituxan). A removable oral device comprising a variable hardness can be used with Tocilizumab (Actemra). A removable oral device comprising a variable hardness can be used with Tofacitinib (Xeljanz). A removable oral device comprising a variable hardness can be used with Natalizumab (Tysabri). A removable oral device comprising a variable hardness can be used with Secukinumab (Cosentyx). A removable oral device comprising a variable hardness can be used with Ustekinumab (Stelara). A removable oral device comprising a variable hardness can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device comprising a variable hardness. In addition, two or more of the biological agents can be used in combination with removable oral device comprising a variable hardness.

[0082] Combinations Comprising Removable Oral Devices With a Camera

[0083] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device which comprises a body comprising a camera. For example, the removable oral device may comprise a palatal element coupled to a clasping element, in which the palatal element is configured to contact a roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. The body comprises a camera within the body of the palatal element with, the camera being configured to capture images of material placed in the mouth of the user. The clasping element is configured to assist in removal of the removable oral device from the mouth.

[0084] Such removable oral devices with a camera can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with a camera can be used in combination with one or more medical devices or implants. For example, a removable oral device with a camera can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with removable oral device comprising a camera.

[0085] In other configurations, a removable oral device comprising a camera can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with a camera in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device comprising a camera.

[0086] In some configurations, the removable oral device comprising a camera can be used with other medical devices. For example, removable oral device comprising a camera can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device comprising a camera can be used with an electrical stimulation system such as the Maestro rechargeable system. A removable oral device comprising a camera can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device comprising a camera can be used with a gastric emptying system such as the Aspire assist system. A removable oral device comprising a camera can be used with a CPAP device. A removable oral device comprising a camera can be used with a knee implant. A removable oral device comprising a camera can be used with a hip implant. A removable oral device comprising a camera can be used with an ankle implant. A removable oral device comprising a camera can be used with a coronary, venous or arterial stent. A removable oral device comprising a camera can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device comprising a camera.

[0087] In other configurations, a removable oral device with a camera can be used pre- operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device comprising a camera can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device comprising a camera can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device comprising a camera can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device comprising a camera.

[0088] In other configurations, a removable oral device comprising a camera can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device comprising a camera is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a camera can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device comprising a camera can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device comprising a camera can be used with a naltrexone hydrochloride and bupropion hydrochloride extended-release tablet such as the drug commercially marketed as Contrave. A removable oral device comprising a camera can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide-1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device comprising a camera can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device comprising a camera can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device comprising a camera can be used with a lorcaserin HC1 such as the drug commercially marketed as Belviq. A removable oral device comprising a camera can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device comprising a camera can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device comprising a camera can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device comprising a camera can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device comprising a camera can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device comprising a camera can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device comprising a camera can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device comprising a camera can be used with any two or more of the weight loss drugs listed herein.

[0089] In some examples, a removable oral device comprising a camera can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with a camera is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a camera can be used with short acting insulin (Humulin and novolin). A removable oral device comprising a camera can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device comprising a camera can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device comprising a camera can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device comprising a camera can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device comprising a camera can be used with a somatostatin. A removable oral device comprising a camera can be used with a diazoxide. A removable oral device comprising a camera can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device comprising a camera can be used with a dopamine agonist such as bromocriptine. A removable oral device comprising a camera can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[0090] In some instances, a removable oral device comprising a camera can be used with glucagon like peptides. For example, a removable oral device comprising a camera can be used with albiglutide (Tanzeum). A removable oral device comprising a camera can be used with dulaglutide (Trulicity). A removable oral device comprising a camera can be used with exenetide (Byetta). A removable oral device comprising a camera can be used with exenatide extended release (Bydureon). A removable oral device comprising a camera can be used with liraglutide (Victoza). A removable oral device comprising a camera can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[0091] In certain examples, a removable oral device comprising a camera can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device comprising a camera can be used with dapagliflozin (Farxiga). A removable oral device comprising a camera can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device comprising a camera can be used with carnagliflozin (Invokana). A removable oral device comprising a camera can be used with canagliflozin-metformin (Invokamet). A removable oral device comprising a camera can be used with empagliflozin (Jardiance). A removable oral device comprising a camera can be used with empagliflozin-linagliptin (Glyxambi).

[0092] In other examples, a removable oral device comprising a camera can be used with a sulfonylurea. For example, a removable oral device comprising a camera can be used with glimepiride (Amaryl). A removable oral device comprising a camera can be used with glimepride-pioglitazone (Duotact). A removable oral device comprising a camera can be used with glimepiride-rosiglitazone (Avendary). A removable oral device comprising a camera can be used with gliclazide, glipizide (Glucotrol). A removable oral device comprising a camera can be used with glipizide-metformin (Metaglip). A removable oral device comprising a camera can be used with glyburide (Diabets, glynase, Micronase). A removable oral device comprising a camera can be used with chloropropamide (Diabinese). A removable oral device comprising a camera can be used with tolazamide (Tolinase). A removable oral device comprising a camera can be used with tolbutamide (Orinase, tol-tab). [0093] In some instances, a removable oral device comprising a camera can be used with a thiazolidinedione. For example, a removable oral device comprising a camera can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device comprising a camera can be used with rosiglitazone-metformin (Amaryl M). A removable oral device comprising a camera can be used with pioglitazone (Actos). A removable oral device comprising a camera can be used with pioglitazone-alogliptin (Oseni), A removable oral device comprising a camera can be used with pilglitazone-glimepride (Duetact). A removable oral device comprising a camera can be used with pioglitazone-metformin (Actoplus met, Actoplus met xr). A removable oral device comprising a camera can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device comprising a camera can be used with a glucagon. If desired, a removable oral device comprising a camera can be used with any two, three or more of the diabetes drugs listed herein.

[0094] In some instances, a removable oral device comprising a camera can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device comprising a camera is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising a camera with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[0095] In certain examples, a removable oral device comprising a camera can be used with diuretic. For example, a removable oral device comprising a camera can be used with chlorthalidone (Hygroton). A removable oral device comprising a camera can be used with chlorothiazide (Diruil). A removable oral device comprising a camera can be used with furosemide (Lasix). A removable oral device comprising a camera can be used with hydrochlorothiazide (Esidrix). A removable oral device comprising a camera can be used with indapamide (Lozol). A removable oral device comprising a camera can be used with metolazone (Mykrox).

[0096] In certain instances, a removable oral device comprising a camera can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device comprising a camera can be used with combination diuretics. For example, A removable oral device comprising a camera can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device comprising a camera can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device comprising a camera can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[0097] In some instances, a removable oral device comprising a camera can be used with a beta blocker. For example, A removable oral device comprising a camera can be used with acebutolol (Sectral). A removable oral device comprising a camera can be used with atenolol (Tenormin). A removable oral device comprising a camera can be used with betaxolol (Kerlone). A removable oral device comprising a camera can be used with bisoprolol fumarate (Zebeta). A removable oral device comprising a camera can be used with cartelol hydrochloride (Cartrol). A removable oral device comprising a camera can be used with metoprolol tartrate (Lopressor). A removable oral device comprising a camera can be used with metoprolol succinate (Toprol-XL). A removable oral device comprising a camera can be used with nadolol (Corgard). A removable oral device comprising a camera can be used with penbutolol sulfate (Levatol). A removable oral device comprising a camera can be used with pindolol (Visken). A removable oral device comprising a camera can be used with propanolol hydrochloride (Inderal). A removable oral device comprising a camera can be used with solotolol hydrochloride (Betapace). A removable oral device comprising a camera can be used with timolol maleate (Blocadren). A removable oral device comprising a camera can be used with, nebivolol (Bystoliv). A removable oral device comprising a camera can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[0098] In some examples, a removable oral device comprising a camera can be used with an acetylcholinesterase inhibitor. For example, a removable oral device comprising a camera can be used with benaxepril hydrochloride (Lotensin). A removable oral device comprising a camera can be used with captopril (Capoten). A removable oral device comprising a camera can be used with enalpril maleate (Vasotec). A removable oral device comprising a camera can be used with fosinopril sodium (Monopril) A removable oral device comprising a camera can be used with lisonopril (Prinivel, Zestril). A removable oral device comprising a camera can be used with moexipril (Univasc). A removable oral device comprising a camera can be used with perindopril (Aceon). A removable oral device comprising a camera can be used with quinapril hydrochloride (Accupril). A removable oral device comprising a camera can be used with ramipril (Altace). A removable oral device comprising a camera can be used with trandolapril (Mavik).

[0099] In certain examples, a removable oral device comprising a camera can be used with an angiotensin II receptor blocker. For example, a removable oral device comprising a camera can be used with candesartan (Atacand). A removable oral device comprising a camera can be used with eprosartan mesylate (Teveten). A removable oral device comprising a camera can be used with irbesartan (Avapro). A removable oral device comprising a camera can be used with losartan potassium (Cozaar). A removable oral device comprising a camera can be used with telmisartan (Micardis). A removable oral device comprising a camera can be used with val sartan (Diovan).

[00100] In certain embodiments, a removable oral device comprising a camera can be used with a calcium channel blocker. For example, a removable oral device comprising a camera can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device comprising a camera can be used with bepridil (Vasocor). A removable oral device comprising a camera can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device comprising a camera can be used with felodipine (Plendil). A removable oral device comprising a camera can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device comprising a camera can be used with nicardipine (Cardene SR). A removable oral device comprising a camera can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device comprising a camera can be used with nisoldipine (Sular). A removable oral device comprising a camera can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00101] In certain embodiments, a removable oral device comprising a camera can be used with an alpha blocker. For example, a removable oral device comprising a camera can be used with doxazosin mesylate (Cardura). A removable oral device comprising a camera can be used with prazosin hydrochloride (Minipress). A removable oral device comprising a camera can be used with terazosin hydrochloride (Hytrin).

[00102] In certain embodiments, a removable oral device comprising a camera can be used with an alpha-2-receptor agonist. For example, a removable oral device comprising a camera can be used with methyldopa.

[00103] In certain embodiments, a removable oral device comprising a camera can be used with combined alpha and beta blockers. For example, a removable oral device comprising a camera can be used with carvedilol (Coreg). A removable oral device comprising a camera can be used with labetalol hydrochloride (Normodyne, Trandate).

[00104] In certain embodiments, a removable oral device comprising a camera can be used with a central agonist. For example, a removable oral device comprising a camera can be used with alpha methyldopa (Aldomet). A removable oral device comprising a camera can be used with clonidine hydrochloride (Catapres). A removable oral device comprising a camera can be used with guanabenz acetate (Wytensin). A removable oral device comprising a camera can be used with guanfacine hydrochloride (Tenex). [00105] In certain embodiments, a removable oral device comprising a camera can be used with a peripheral adrenergic inhibitor. . For example, a removable oral device comprising a camera can be used with guanadrel (Hylorel). A removable oral device comprising a camera can be used with guanethidine monosulfate (Ismelin). A removable oral device comprising a camera can be used with reserpine (Serpasil).

[00106] In certain embodiments, a removable oral device comprising a camera can be used with a blood vessel dilator (vasodilator). For example, a removable oral device comprising a camera can be used with hydralazine hydrocholoride (Apresoline). A removable oral device comprising a camera can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device comprising a camera.

[00107] In some examples, a removable oral device comprising a camera can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device comprising a camera is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising a camera with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00108] In certain examples, a removable oral device comprising a camera can be used with a statin. For example, a removable oral device comprising a camera can be used with an atorvastatin (Lipitor). A removable oral device comprising a camera can be used with a fluvastatin (Lescol). A removable oral device comprising a camera can be used with a rosuvastatin (Crestor). A removable oral device comprising a camera can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device comprising a camera.

[00109] In certain examples, a removable oral device comprising a camera can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device comprising a camera can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device comprising a camera. [00110] In certain examples, a removable oral device comprising a camera can be used with a resin (bile-acid binding drugs). For example, a removable oral device comprising a camera can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device comprising a camera can be used with colestipol (Colestid®). A removable oral device comprising a camera can be used with colesevelam HC1 (WelChol®). If desired, two or more of resins can be used in combination with removable oral device comprising a camera.

[00111] In some examples, a removable oral device comprising a camera can be used with lipid lowering therapies. For example, a removable oral device comprising a camera can be used with gemfibrozil (Lopid®). A removable oral device comprising a camera can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device comprising a camera can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device comprising a camera.

[00112] In some examples, a removable oral device comprising a camera can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device comprising a camera can provide both short term and long term treatment. In some examples, a removable oral device comprising a camera can be used with Abatacept (Orencia). A removable oral device comprising a camera can be used with Adalimumab (Humira). A removable oral device comprising a camera can be used with Adalimumab -atto (Amjevita), a biosimilar to Humira. A removable oral device comprising a camera can be used with Anakinra (Kineret). A removable oral device comprising a camera can be used with Certolizumab pegol (Cimzia). A removable oral device comprising a camera can be used with Etanercept (Enbrel). A removable oral device comprising a camera can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device comprising a camera can be used with Golimumab (Simponi, Simponi Aria). A removable oral device comprising a camera can be used with Infliximab (Remicade). A removable oral device comprising a camera can be used with Infliximab-dyyb (Inflectra), a biosimilar to Remicade. A removable oral device comprising a camera can be used with Rituximab (Rituxan). A removable oral device comprising a camera can be used with Tocilizumab (Actemra). A removable oral device comprising a camera can be used with Tofacitinib (Xeljanz). A removable oral device comprising a camera can be used with Natalizumab (Tysabri). A removable oral device comprising a camera can be used with Secukinumab (Cosentyx). A removable oral device comprising a camera can be used with

Ustekinumab (Stelara). A removable oral device comprising a camera can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device comprising a camera. In addition, two or more of the biological agents can be used in combination with removable oral device comprising a camera.

[00113] Combinations Comprising Removable Oral Devices with an Electrode

[00114] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device which comprises a body comprising an electrode. For example, the removable oral device may comprise a palatal element coupled to a clasping element, in which the palatal element is configured to contact a roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. The body comprises an electrode within the body of the palatal element with the electrode exposed to fluid entering and exiting the mouth of the user. For example, the at least one electrode can be configured to measure athletic performance (or other physiological parameters) from the fluid entering, within and/or exiting the mouth of the user. If desired, the electrode can also measure solids and/or gases entering into the mouth. The clasping element is configured to assist in removal of the removable oral device from the mouth.

[00115] Such removable oral devices with an electrode can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with an electrode can be used in combination with one or more medical devices or implants. For example, a removable oral device with an electrode can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with removable oral device comprising an electrode.

[00116] In other configurations, a removable oral device comprising an electrode can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with an electrode in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device comprising an electrode.

[00117] In some configurations, the removable oral device comprising an electrode can be used with other medical devices. For example, removable oral device comprising an electrode can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device comprising an electrode can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device comprising an electrode can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device comprising an electrode can be used with a gastric emptying system such as the Aspire assist system. A removable oral device comprising an electrode can be used with a CPAP device. A removable oral device comprising an electrode can be used with a knee implant. A removable oral device comprising an electrode can be used with a hip implant. A removable oral device comprising an electrode can be used with an ankle implant. A removable oral device comprising an electrode can be used with a coronary, venous or arterial stent. A removable oral device comprising an electrode can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device comprising an electrode.

[00118] In other configurations, a removable oral device with an electrode can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device comprising an electrode can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device comprising an electrode can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device comprising an electrode can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device comprising an electrode.

[00119] In other configurations, a removable oral device comprising an electrode can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device comprising an electrode is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising an electrode can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device comprising an electrode can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device comprising an electrode can be used with a naltrexone hydrochloride and bupropion hydrochloride extended- release tablet such as the drug commercially marketed as Contrave. A removable oral device comprising an electrode can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide-1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device comprising an electrode can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device comprising an electrode can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device comprising an electrode can be used with a lorcaserin HC1 such as the drug commercially marketed as Belviq. A removable oral device comprising an electrode can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device comprising an electrode can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device comprising an electrode can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device comprising an electrode can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device comprising an electrode can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device comprising an electrode can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device comprising an electrode can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device comprising an electrode can be used with any two or more of the weight loss drugs listed herein.

[00120] In some examples, a removable oral device comprising an electrode can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with an electrode is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising an electrode can be used with short acting insulin (Humulin and novolin). A removable oral device comprising an electrode can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device comprising an electrode can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device comprising an electrode can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device comprising an electrode can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device comprising an electrode can be used with a somatostatin. A removable oral device comprising an electrode can be used with a diazoxide. A removable oral device comprising an electrode can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device comprising an electrode can be used with a dopamine agonist such as bromocriptine. A removable oral device comprising an electrode can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00121] In some instances, a removable oral device comprising an electrode can be used with glucagon like peptides. For example, a removable oral device comprising an electrode can be used with albiglutide (Tanzeum). A removable oral device comprising an electrode can be used with dulaglutide (Trulicity). A removable oral device comprising an electrode can be used with exenetide (Byetta). A removable oral device comprising an electrode can be used with exenatide extended release (Bydureon). A removable oral device comprising an electrode can be used with liraglutide (Victoza). A removable oral device comprising an electrode can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00122] In certain examples, a removable oral device comprising an electrode can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device comprising an electrode can be used with dapagliflozin (Farxiga). A removable oral device comprising an electrode can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device comprising an electrode can be used with carnagliflozin (Invokana). A removable oral device comprising an electrode can be used with canagliflozin-metformin (Invokamet). A removable oral device comprising an electrode can be used with empagliflozin (Jardiance). A removable oral device comprising an electrode can be used with empagliflozin-linagliptin (Glyxambi).

[00123] In other examples, a removable oral device comprising an electrode can be used with a sulfonylurea. For example, a removable oral device comprising an electrode can be used with glimepiride (Amaryl). A removable oral device comprising an electrode can be used with glimepride-pioglitazone (Duotact). A removable oral device comprising an electrode can be used with glimepiride-rosiglitazone (Avendary). A removable oral device comprising an electrode can be used with gliclazide, glipizide (Glucotrol). A removable oral device comprising an electrode can be used with glipizide-metformin (Metaglip). A removable oral device comprising an electrode can be used with glyburide (Diabets, glynase, Micronase). A removable oral device comprising an electrode can be used with chloropropamide (Diabinese). A removable oral device comprising an electrode can be used with tolazamide (Tolinase). A removable oral device comprising an electrode can be used with tolbutamide (Orinase, tol-tab).

[00124] In some instances, a removable oral device comprising an electrode can be used with a thiazolidinedione. For example, a removable oral device comprising an electrode can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device comprising an electrode can be used with rosiglitazone-metformin (Amaryl M). A removable oral device comprising an electrode can be used with pioglitazone (Actos). A removable oral device comprising an electrode can be used with pioglitazone-alogliptin (Oseni), A removable oral device comprising an electrode can be used with pilglitazone-glimepride (Duetact). A removable oral device comprising an electrode can be used with pioglitazone- metformin (Actoplus met, Actoplus met xr). A removable oral device comprising an electrode can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device comprising an electrode can be used with a glucagon. If desired, a removable oral device comprising an electrode can be used with any two, three or more of the diabetes drugs listed herein.

[00125] In some instances, a removable oral device comprising an electrode can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device comprising an electrode is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising an electrode with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00126] In certain examples, a removable oral device comprising an electrode can be used with diuretic. For example, a removable oral device comprising an electrode can be used with chlorthalidone (Hygroton). A removable oral device comprising an electrode can be used with chlorothiazide (Diruil). A removable oral device comprising an electrode can be used with furosemide (Lasix). A removable oral device comprising an electrode can be used with hydrochlorothiazide (Esidrix). A removable oral device comprising an electrode can be used with indapamide (Lozol). A removable oral device comprising an electrode can be used with metolazone (Mykrox).

[00127] In certain instances, a removable oral device comprising an electrode can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device comprising an electrode can be used with combination diuretics. For example, A removable oral device comprising an electrode can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device comprising an electrode can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device comprising an electrode can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00128] In some instances, a removable oral device comprising an electrode can be used with a beta blocker. For example, A removable oral device comprising an electrode can be used with acebutolol (Sectral). A removable oral device comprising an electrode can be used with atenolol (Tenormin). A removable oral device comprising an electrode can be used with betaxolol (Kerlone). A removable oral device comprising an electrode can be used with bisoprolol fumarate (Zebeta). A removable oral device comprising an electrode can be used with cartelol hydrochloride (Cartrol). A removable oral device comprising an electrode can be used with metoprolol tartrate (Lopressor). A removable oral device comprising an electrode can be used with metoprolol succinate (Toprol-XL). A removable oral device comprising an electrode can be used with nadolol (Corgard). A removable oral device comprising an electrode can be used with penbutolol sulfate (Levatol). A removable oral device comprising an electrode can be used with pindolol (Visken). A removable oral device comprising an electrode can be used with propanolol hydrochloride (Inderal). A removable oral device comprising an electrode can be used with solotolol hydrochloride (Betapace). A removable oral device comprising an electrode can be used with timolol maleate (Blocadren). A removable oral device comprising an electrode can be used with, nebivolol (Bystoliv). A removable oral device comprising an electrode can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00129] In some examples, a removable oral device comprising an electrode can be used with an acetylcholinesterase inhibitor. For example, a removable oral device comprising an electrode can be used with benaxepril hydrochloride (Lotensin). A removable oral device comprising an electrode can be used with captopril (Capoten). A removable oral device comprising an electrode can be used with enalpril maleate (Vasotec). A removable oral device comprising an electrode can be used with fosinopril sodium (Monopril) A removable oral device comprising an electrode can be used with lisonopril (Prinivel, Zestril). A removable oral device comprising an electrode can be used with moexipril (Univasc). A removable oral device comprising an electrode can be used with perindopril (Aceon). A removable oral device comprising an electrode can be used with quinapril hydrochloride (Accupril). A removable oral device comprising an electrode can be used with ramipril (Altace). A removable oral device comprising an electrode can be used with trandolapril (Mavik). [00130] In certain examples, a removable oral device comprising an electrode can be used with an angiotensin II receptor blocker. For example, a removable oral device comprising an electrode can be used with candesartan (Atacand). A removable oral device comprising an electrode can be used with eprosartan mesylate (Teveten). A removable oral device comprising an electrode can be used with irbesartan (Avapro). A removable oral device comprising an electrode can be used with losartan potassium (Cozaar). A removable oral device comprising an electrode can be used with telmisartan (Micardis). A removable oral device comprising an electrode can be used with valsartan (Diovan).

[00131] In certain embodiments, a removable oral device comprising an electrode can be used with a calcium channel blocker. For example, a removable oral device comprising an electrode can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device comprising an electrode can be used with bepridil (Vasocor). A removable oral device comprising an electrode can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device comprising an electrode can be used with felodipine (Plendil). A removable oral device comprising an electrode can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device comprising an electrode can be used with nicardipine (Cardene SR). A removable oral device comprising an electrode can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device comprising an electrode can be used with nisoldipine (Sular). A removable oral device comprising an electrode can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00132] In certain embodiments, a removable oral device comprising an electrode can be used with an alpha blocker. For example, a removable oral device comprising an electrode can be used with doxazosin mesylate (Cardura). A removable oral device comprising an electrode can be used with prazosin hydrochloride (Minipress). A removable oral device comprising an electrode can be used with terazosin hydrochloride (Hytrin).

[00133] In certain embodiments, a removable oral device comprising an electrode can be used with an alpha-2-receptor agonist. For example, a removable oral device comprising an electrode can be used with methyldopa.

[00134] In certain embodiments, a removable oral device comprising an electrode can be used with combined alpha and beta blockers. For example, a removable oral device comprising an electrode can be used with carvedilol (Coreg). A removable oral device comprising an electrode can be used with labetalol hydrochloride (Normodyne, Trandate).

[00135] In certain embodiments, a removable oral device comprising an electrode can be used with a central agonist. For example, a removable oral device comprising an electrode can be used with alpha methyldopa (Aldomet). A removable oral device comprising an electrode can be used with clonidine hydrochloride (Catapres). A removable oral device comprising an electrode can be used with guanabenz acetate (Wytensin). A removable oral device comprising an electrode can be used with guanfacine hydrochloride (Tenex).

[00136] In certain embodiments, a removable oral device comprising an electrode can be used with a peripheral adrenergic inhibitor. For example, a removable oral device comprising an electrode can be used with guanadrel (Hylorel). A removable oral device comprising an electrode can be used with guanethidine monosulfate (Ismelin). A removable oral device comprising an electrode can be used with reserpine (Serpasil).

[00137] In certain embodiments, a removable oral device comprising an electrode can be used with a blood vessel dilator (vasodilator). For example, a removable oral device comprising an electrode can be used with hydralazine hydrocholoride (Apresoline). A removable oral device comprising an electrode can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device comprising an electrode.

[00138] In some examples, a removable oral device comprising an electrode can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device comprising an electrode is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising an electrode with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00139] In certain examples, a removable oral device comprising an electrode can be used with a statin. For example, a removable oral device comprising an electrode can be used with an atorvastatin (Lipitor). A removable oral device comprising an electrode can be used with a fluvastatin (Lescol). A removable oral device comprising an electrode can be used with a rosuvastatin (Crestor). A removable oral device comprising an electrode can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device comprising an electrode.

[00140] In certain examples, a removable oral device comprising an electrode can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device comprising an electrode can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device comprising an electrode.

[00141] In certain examples, a removable oral device comprising an electrode can be used with a resin (bile-acid binding drugs). For example, a removable oral device comprising an electrode can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device comprising an electrode can be used with colestipol (Colestid®). A removable oral device comprising an electrode can be used with colesevelam HCl (WelChol®). If desired, two or more of resins can be used in combination with removable oral device comprising an electrode.

[00142] In some examples, a removable oral device comprising an electrode can be used with lipid lowering therapies. For example, a removable oral device comprising an electrode can be used with gemfibrozil (Lopid®). A removable oral device comprising an electrode can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device comprising an electrode can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device comprising an electrode.

[00143] In some examples, a removable oral device comprising an electrode can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device comprising an electrode can provide both short term and long term treatment. In some examples, a removable oral device comprising an electrode can be used with Abatacept (Orencia). A removable oral device comprising an electrode can be used with Adalimumab (Humira). A removable oral device comprising an electrode can be used with Adalimumab -atto (Amjevita), a biosimilar to Humira. A removable oral device comprising an electrode can be used with Anakinra (Kineret). A removable oral device comprising an electrode can be used with Certolizumab pegol (Cimzia). A removable oral device comprising an electrode can be used with Etanercept (Enbrel). A removable oral device comprising an electrode can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device comprising an electrode can be used with Golimumab (Simponi, Simponi Aria). A removable oral device comprising an electrode can be used with Infliximab (Remicade). A removable oral device comprising an electrode can be used with Infliximab -dyyb (Inflectra), a biosimilar to Remicade. A removable oral device comprising an electrode can be used with Rituximab (Rituxan). A removable oral device comprising an electrode can be used with Tocilizumab (Actemra). A removable oral device comprising an electrode can be used with Tofacitinib (Xeljanz). A removable oral device comprising an electrode can be used with Natalizumab (Tysabri). A removable oral device comprising an electrode can be used with Secukinumab (Cosentyx). A removable oral device comprising an electrode can be used with Ustekinumab (Stelara). A removable oral device comprising an electrode can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device comprising an electrode. In addition, two or more of the biological agents can be used in combination with removable oral device comprising an electrode.

[00144] Combinations Comprising Removable Oral Devices with a Bar Code Reader

[00145] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device which comprises a body comprising a bar code reader. For example, the removable oral device may comprise a palatal element coupled to a clasping element, in which the palatal element is configured to contact a roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. The body comprises a bar code reader within the body of the palatal element with the bar code reader configured to read a bar code present on a material placed in the mouth of the user. For example, the bar code reader can read bar codes on drugs and other devices or materials placed in the mouth to ensure intake. The clasping element is configured to assist in removal of the removable oral device from the mouth.

[00146] Such removable oral devices with a bar code reader can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with a bar code reader can be used in combination with one or more medical devices or implants. For example, a removable oral device with a bar code reader can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with removable oral device comprising a bar code reader. [00147] In other configurations, a removable oral device comprising a bar code reader can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with a bar code reader in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device comprising a bar code reader.

[00148] In some configurations, the removable oral device comprising a bar code reader can be used with other medical devices. For example, removable oral device comprising a bar code reader can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device comprising a bar code reader can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device comprising a bar code reader can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device comprising a bar code reader can be used with a gastric emptying system such as the Aspire assist system. A removable oral device comprising a bar code reader can be used with a CPAP device. A removable oral device comprising a bar code reader can be used with a knee implant. A removable oral device comprising a bar code reader can be used with a hip implant. A removable oral device comprising a bar code reader can be used with an ankle implant. A removable oral device comprising a bar code reader can be used with a coronary, venous or arterial stent. A removable oral device comprising a bar code reader can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device comprising a bar code reader.

[00149] In other configurations, a removable oral device with a bar code reader can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device comprising a bar code reader can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device comprising a bar code reader can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device comprising a bar code reader can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device comprising a bar code reader.

[00150] In other configurations, a removable oral device comprising a bar code reader can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device comprising a bar code reader is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a bar code reader can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device comprising a bar code reader can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device comprising a bar code reader can be used with a naltrexone hydrochloride and bupropion hydrochloride extended- release tablet such as the drug commercially marketed as Contrave. A removable oral device comprising a bar code reader can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide- 1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device comprising a bar code reader can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device comprising a bar code reader can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device comprising a bar code reader can be used with a lorcaserin HC1 such as the drug commercially marketed as Belviq. A removable oral device comprising a bar code reader can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device comprising a bar code reader can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device comprising a bar code reader can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device comprising a bar code reader can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device comprising a bar code reader can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device comprising a bar code reader can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device comprising a bar code reader can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device comprising a bar code reader can be used with any two or more of the weight loss drugs listed herein.

[00151] In some examples, a removable oral device comprising a bar code reader can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with a bar code reader is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a bar code reader can be used with short acting insulin (Humulin and novolin). A removable oral device comprising a bar code reader can be used with rapid acting insulin (Novolog, flexpen,

Apidra, Humalog). A removable oral device comprising a bar code reader can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device comprising a bar code reader can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device comprising a bar code reader can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device comprising a bar code reader can be used with a somatostatin. A removable oral device comprising a bar code reader can be used with a diazoxide. A removable oral device comprising a bar code reader can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device comprising a bar code reader can be used with a dopamine agonist such as bromocriptine. A removable oral device comprising a bar code reader can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00152] In some instances, a removable oral device comprising a bar code reader can be used with glucagon like peptides. For example, a removable oral device comprising a bar code reader can be used with albiglutide (Tanzeum). A removable oral device comprising a bar code reader can be used with dulaglutide (Trulicity). A removable oral device comprising a bar code reader can be used with exenetide (Byetta). A removable oral device comprising a bar code reader can be used with exenatide extended release (Bydureon). A removable oral device comprising a bar code reader can be used with liraglutide (Victoza). A removable oral device comprising a bar code reader can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00153] In certain examples, a removable oral device comprising a bar code reader can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device comprising a bar code reader can be used with dapagliflozin (Farxiga). A removable oral device comprising a bar code reader can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device comprising a bar code reader can be used with carnagliflozin (Invokana). A removable oral device comprising a bar code reader can be used with canagliflozin-metformin (Invokamet). A removable oral device comprising a bar code reader can be used with empagliflozin (Jardiance). A removable oral device comprising a bar code reader can be used with empagliflozin-linagliptin (Glyxambi).

[00154] In other examples, a removable oral device comprising a bar code reader can be used with a sulfonylurea. For example, a removable oral device comprising a bar code reader can be used with glimepiride (Amaryl). A removable oral device comprising a bar code reader can be used with glimepride-pioglitazone (Duotact). A removable oral device comprising a bar code reader can be used with glimepiride-rosiglitazone (Avendary). A removable oral device comprising a bar code reader can be used with gliclazide, glipizide (Glucotrol). A removable oral device comprising a bar code reader can be used with glipizide-metformin (Metaglip). A removable oral device comprising a bar code reader can be used with glyburide (Diabets, glynase, Micronase). A removable oral device comprising a bar code reader can be used with chloropropamide (Diabinese). A removable oral device comprising a bar code reader can be used with tolazamide (Tolinase). A removable oral device comprising a bar code reader can be used with tolbutamide (Orinase, tol-tab).

[00155] In some instances, a removable oral device comprising a bar code reader can be used with a thiazolidinedione. For example, a removable oral device comprising a bar code reader can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device comprising a bar code reader can be used with rosiglitazone-metformin (Amaryl M). A removable oral device comprising a bar code reader can be used with pioglitazone (Actos). A removable oral device comprising a bar code reader can be used with pioglitazone-alogliptin (Oseni), A removable oral device comprising a bar code reader can be used with pilglitazone-glimepride (Duetact). A removable oral device comprising a bar code reader can be used with pioglitazone-metformin (Actoplus met, Actoplus met xr). A removable oral device comprising a bar code reader can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device comprising a bar code reader can be used with a glucagon. If desired, a removable oral device comprising a bar code reader can be used with any two, three or more of the diabetes drugs listed herein.

[00156] In some instances, a removable oral device comprising a bar code reader can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device comprising a bar code reader is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising a bar code reader with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device comprising a bar code reader to control weight and/or promote weight loss.

[00157] In certain examples, a removable oral device comprising a bar code reader can be used with diuretic. For example, a removable oral device comprising a bar code reader can be used with chlorthalidone (Hygroton). A removable oral device comprising a bar code reader can be used with chlorothiazide (Diruil). A removable oral device comprising a bar code reader can be used with furosemide (Lasix). A removable oral device comprising a bar code reader can be used with hydrochlorothiazide (Esidrix). A removable oral device comprising a bar code reader can be used with indapamide (Lozol). A removable oral device comprising a bar code reader can be used with metolazone (Mykrox).

[00158] In certain instances, a removable oral device comprising a bar code reader can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device comprising a bar code reader can be used with combination diuretics. For example, A removable oral device comprising a bar code reader can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device comprising a bar code reader can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device comprising a bar code reader can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00159] In some instances, a removable oral device comprising a bar code reader can be used with a beta blocker. For example, A removable oral device comprising a bar code reader can be used with acebutolol (Sectral). A removable oral device comprising a bar code reader can be used with atenolol (Tenormin). A removable oral device comprising a bar code reader can be used with betaxolol (Kerlone). A removable oral device comprising a bar code reader can be used with bisoprolol fumarate (Zebeta). A removable oral device comprising a bar code reader can be used with cartelol hydrochloride (Cartrol). A removable oral device comprising a bar code reader can be used with metoprolol tartrate (Lopressor). A removable oral device comprising a bar code reader can be used with metoprolol succinate (Toprol-XL). A removable oral device comprising a bar code reader can be used with nadolol (Corgard). A removable oral device comprising a bar code reader can be used with penbutolol sulfate (Levatol). A removable oral device comprising a bar code reader can be used with pindolol (Visken). A removable oral device comprising a bar code reader can be used with propanolol hydrochloride (Inderal). A removable oral device comprising a bar code reader can be used with solotolol hydrochloride (Betapace). A removable oral device comprising a bar code reader can be used with timolol maleate (Blocadren). A removable oral device comprising a bar code reader can be used with, nebivolol (Bystoliv). A removable oral device comprising a bar code reader can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00160] In some examples, a removable oral device comprising a bar code reader can be used with an acetylcholinesterase inhibitor. For example, a removable oral device comprising a bar code reader can be used with benaxepril hydrochloride (Lotensin). A removable oral device comprising a bar code reader can be used with captopril (Capoten). A removable oral device comprising a bar code reader can be used with enalpril maleate (Vasotec). A removable oral device comprising a bar code reader can be used with fosinopril sodium (Monopril) A removable oral device comprising a bar code reader can be used with lisonopril (Prinivel, Zestril). A removable oral device comprising a bar code reader can be used with moexipril (Univasc). A removable oral device comprising a bar code reader can be used with perindopril (Aceon). A removable oral device comprising a bar code reader can be used with quinapril hydrochloride (Accupril). A removable oral device comprising a bar code reader can be used with ramipril (Altace). A removable oral device comprising a bar code reader can be used with trandolapril (Mavik).

[00161] In certain examples, a removable oral device comprising a bar code reader can be used with an angiotensin II receptor blocker. For example, a removable oral device comprising a bar code reader can be used with candesartan (Atacand). A removable oral device comprising a bar code reader can be used with eprosartan mesylate (Teveten). A removable oral device comprising a bar code reader can be used with irbesartan (Avapro). A removable oral device comprising a bar code reader can be used with losartan potassium (Cozaar). A removable oral device comprising a bar code reader can be used with telmisartan (Micardis). A removable oral device comprising a bar code reader can be used with valsartan (Diovan).

[00162] In certain embodiments, a removable oral device comprising a bar code reader can be used with a calcium channel blocker. For example, a removable oral device comprising a bar code reader can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device comprising a bar code reader can be used with bepridil (Vasocor). A removable oral device comprising a bar code reader can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device comprising a bar code reader can be used with felodipine (Plendil). A removable oral device comprising a bar code reader can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device comprising a bar code reader can be used with nicardipine (Cardene SR). A removable oral device comprising a bar code reader can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device comprising a bar code reader can be used with nisoldipine (Sular). A removable oral device comprising a bar code reader can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00163] In certain embodiments, a removable oral device comprising a bar code reader can be used with an alpha blocker. For example, a removable oral device comprising a bar code reader can be used with doxazosin mesylate (Cardura). A removable oral device comprising a bar code reader can be used with prazosin hydrochloride (Minipress). A removable oral device comprising a bar code reader can be used with terazosin hydrochloride (Hytrin). [00164] In certain embodiments, a removable oral device comprising a bar code reader can be used with an alpha-2-receptor agonist. For example, a removable oral device comprising a bar code reader can be used with methyldopa.

[00165] In certain embodiments, a removable oral device comprising a bar code reader can be used with combined alpha and beta blockers. For example, a removable oral device comprising a bar code reader can be used with carvedilol (Coreg). A removable oral device comprising a bar code reader can be used with labetalol hydrochloride (Normodyne, Trandate).

[00166] In certain embodiments, a removable oral device comprising a bar code reader can be used with a central agonist. For example, a removable oral device comprising a bar code reader can be used with alpha methyldopa (Aldomet). A removable oral device comprising a bar code reader can be used with clonidine hydrochloride (Catapres). A removable oral device comprising a bar code reader can be used with guanabenz acetate (Wytensin). A removable oral device comprising a bar code reader can be used with guanfacine hydrochloride (Tenex).

[00167] In certain embodiments, a removable oral device comprising a bar code reader can be used with a peripheral adrenergic inhibitor. For example, a removable oral device comprising a bar code reader can be used with guanadrel (Hylorel). A removable oral device comprising a bar code reader can be used with guanethidine monosulfate (Ismelin). A removable oral device comprising a bar code reader can be used with reserpine (Serpasil).

[00168] In certain embodiments, a removable oral device comprising a bar code reader can be used with a blood vessel dilator (vasodilator). For example, a removable oral device comprising a bar code reader can be used with hydralazine hydrocholoride (Apresoline). A removable oral device comprising a bar code reader can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device comprising a bar code reader.

[00169] In some examples, a removable oral device comprising a bar code reader can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device comprising a bar code reader is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising a bar code reader with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00170] In certain examples, a removable oral device comprising a bar code reader can be used with a statin. For example, a removable oral device comprising a bar code reader can be used with an atorvastatin (Lipitor). A removable oral device comprising a bar code reader can be used with a fluvastatin (Lescol). A removable oral device comprising a bar code reader can be used with a rosuvastatin (Crestor). A removable oral device comprising a bar code reader can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device comprising a bar code reader.

[00171] In certain examples, a removable oral device comprising a bar code reader can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device comprising a bar code reader can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device comprising a bar code reader.

[00172] In certain examples, a removable oral device comprising a bar code reader can be used with a resin (bile-acid binding drugs). For example, a removable oral device comprising a bar code reader can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device comprising a bar code reader can be used with colestipol (Colestid®). A removable oral device comprising a bar code reader can be used with colesevelam HC1 (WelChol®). If desired, two or more of resins can be used in combination with removable oral device comprising a bar code reader.

[00173] In some examples, a removable oral device comprising a bar code reader can be used with lipid lowering therapies. For example, a removable oral device comprising a bar code reader can be used with gemfibrozil (Lopid®). A removable oral device comprising a bar code reader can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device comprising a bar code reader can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device comprising a bar code reader.

[00174] In some examples, a removable oral device comprising a bar code reader can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device comprising a bar code reader can provide both short term and long term treatment. In some examples, a removable oral device comprising a bar code reader can be used with Abatacept (Orencia). A removable oral device comprising a bar code reader can be used with Adalimumab (Humira). A removable oral device comprising a bar code reader can be used with Adalimumab-atto (Amjevita), a biosimilar to Humira. A removable oral device comprising a bar code reader can be used with Anakinra (Kineret). A removable oral device comprising a bar code reader can be used with Certolizumab pegol (Cimzia). A removable oral device comprising a bar code reader can be used with Etanercept (Enbrel). A removable oral device comprising a bar code reader can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device comprising a bar code reader can be used with Golimumab (Simponi, Simponi Aria). A removable oral device comprising a bar code reader can be used with Infliximab (Remicade). A removable oral device comprising a bar code reader can be used with Infliximab-dyyb (Inflectra), a biosimilar to Remicade. A removable oral device comprising a bar code reader can be used with Rituximab (Rituxan). A removable oral device comprising a bar code reader can be used with Tocilizumab (Actemra). A removable oral device comprising a bar code reader can be used with Tofacitinib (Xeljanz). A removable oral device comprising a bar code reader can be used with Natalizumab (Tysabri). A removable oral device comprising a bar code reader can be used with Secukinumab (Cosentyx). A removable oral device comprising a bar code reader can be used with Ustekinumab (Stelara). A removable oral device comprising a bar code reader can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device comprising a bar code reader. In addition, two or more of the biological agents can be used in combination with removable oral device comprising a bar code reader.

[00175] In some examples, the removable oral device comprising a bar code reader can be used in combination with an opioid or narcotic drug comprising a bar code. For example, the bar code reader can read the bar code on the narcotic to monitor drug intake compliance. Where a narcotic with a bar code is used in combination with a removable oral device comprising a bar code reader, the narcotic may be, for example, codeine, hydrocodone, oxycodone, oxycontin, methadone, hydromorphone, morphine, opium, fentanyl, heroin, buprenorphine, levorphanol, lorcet, Lortab, norco, oncet, procet, Vicodin, xodol, zydone and combinations thereof.

[00176] In other examples, the bar code reader can be used in combination with an opioid or narcotic drug comprising a bar code. For example, the bar code reader can read the bar code on the narcotic to monitor drug intake compliance. Where a narcotic with a bar code is used in combination with a removable oral device comprising a bar code reader, the narcotic may be, for example, codeine, hydrocodone, oxycodone, oxycontin, methadone, hydromorphone, morphine, opium, fentanyl, heroin, buprenorphine, levorphanol, lorcet, Lortab, norco, oncet, procet, Vicodin, xodol, zydone and combinations thereof. [00177] Combinations Comprising Removable Oral Devices with a Processor

[00178] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device which comprises a body comprising a processor. For example, the removable oral device may comprise a palatal element coupled to a clasping element, in which the palatal element is configured to contact a roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. The body comprises a processor and optionally one or more memory units or other electrical components. If desired, the memory unit may comprise patient information such as, for example, an electronic medical record of the user. The clasping element is configured to assist in removal of the removable oral device from the mouth. Illustrative types of processor are described in the commonly assigned SCIINTAK-700100 application referenced herein.

[00179] Such removable oral devices with a processor can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with a processor can be used in combination with one or more medical devices or implants. For example, a removable oral device with a processor can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with removable oral device comprising a processor.

[00180] In other configurations, a removable oral device comprising a processor can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with a processor in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device comprising a processor. [00181] In some examples, a removable oral device comprising a processor can be used to monitor or send environmental conditions at frequent intervals to determine in vivo device use. For example, the processor can be configured to monitor use compliance of the removable oral device. Compliance monitoring may be particularly desirable when the removable oral device comprising the processor is used to treat overweight and /or obesity,

[00182] In some configurations, the removable oral device comprising a processor can be used with other medical devices. For example, removable oral device comprising a processor can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device comprising a processor can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device comprising a processor can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device comprising a processor can be used with a gastric emptying system such as the Aspire assist system. A removable oral device comprising a processor can be used with a CPAP device. A removable oral device comprising a processor can be used with a knee implant. A removable oral device comprising a processor can be used with a hip implant. A removable oral device comprising a processor can be used with an ankle implant. A removable oral device comprising a processor can be used with a coronary, venous or arterial stent. A removable oral device comprising a processor can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device comprising a processor.

[00183] In other configurations, a removable oral device with a processor can be used pre- operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device comprising a processor can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device comprising a processor can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device comprising a processor can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device comprising a processor.

[00184] In other configurations, a removable oral device comprising a processor can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device comprising a processor is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a processor can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device comprising a processor can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device comprising a processor can be used with a naltrexone hydrochloride and bupropion hydrochloride extended-release tablet such as the drug commercially marketed as Contrave. A removable oral device comprising a processor can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide-1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device comprising a processor can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device comprising a processor can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device comprising a processor can be used with a lorcaserin HC1 such as the drug commercially marketed as Belviq. A removable oral device comprising a processor can be used with an orlistat such as those commercially marketed as Alli and Xenical. A removable oral device comprising a processor can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device comprising a processor can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device comprising a processor can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device comprising a processor can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device comprising a processor can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device comprising a processor can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device comprising a processor can be used with any two or more of the weight loss drugs listed herein.

[00185] In some examples, a removable oral device comprising a processor can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with a processor is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a processor can be used with short acting insulin (Humulin and novolin). A removable oral device comprising a processor can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device comprising a processor can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device comprising a processor can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device comprising a processor can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device comprising a processor can be used with a somatostatin. A removable oral device comprising a processor can be used with a diazoxide. A removable oral device comprising a processor can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device comprising a processor can be used with a dopamine agonist such as bromocriptine. A removable oral device comprising a processor can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00186] In some instances, a removable oral device comprising a processor can be used with glucagon like peptides. For example, a removable oral device comprising a processor can be used with albiglutide (Tanzeum). A removable oral device comprising a processor can be used with dulaglutide (Trulicity). A removable oral device comprising a processor can be used with exenetide (Byetta). A removable oral device comprising a processor can be used with exenatide extended release (Bydureon). A removable oral device comprising a processor can be used with liraglutide (Victoza). A removable oral device comprising a processor can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00187] In certain examples, a removable oral device comprising a processor can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device comprising a processor can be used with dapagliflozin (Farxiga). A removable oral device comprising a processor can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device comprising a processor can be used with carnagliflozin (Invokana). A removable oral device comprising a processor can be used with canagliflozin-metformin (Invokamet). A removable oral device comprising a processor can be used with empagliflozin (Jardiance). A removable oral device comprising a processor can be used with empagliflozin-linagliptin (Glyxambi).

[00188] In other examples, a removable oral device comprising a processor can be used with a sulfonylurea. For example, a removable oral device comprising a processor can be used with glimepiride (Amaryl). A removable oral device comprising a processor can be used with glimepride-pioglitazone (Duotact). A removable oral device comprising a processor can be used with glimepiride-rosiglitazone (Avendary). A removable oral device comprising a processor can be used with gliclazide, glipizide (Glucotrol). A removable oral device comprising a processor can be used with glipizide-metformin (Metaglip). A removable oral device comprising a processor can be used with glyburide (Diabets, glynase, Micronase). A removable oral device comprising a processor can be used with chloropropamide (Diabinese). A removable oral device comprising a processor can be used with tolazamide (Tolinase). A removable oral device comprising a processor can be used with tolbutamide (Orinase, tol-tab).

[00189] In some instances, a removable oral device comprising a processor can be used with a thiazolidinedione. For example, a removable oral device comprising a processor can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device comprising a processor can be used with rosiglitazone-metformin (Amaryl M). A removable oral device comprising a processor can be used with pioglitazone (Actos). A removable oral device comprising a processor can be used with pioglitazone-alogliptin (Oseni), A removable oral device comprising a processor can be used with pilglitazone-glimepride (Duetact). A removable oral device comprising a processor can be used with pioglitazone- metformin (Actoplus met, Actoplus met xr). A removable oral device comprising a processor can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device comprising a processor can be used with a glucagon. If desired, a removable oral device comprising a processor can be used with any two, three or more of the diabetes drugs listed herein.

[00190] In some instances, a removable oral device comprising a processor can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device comprising a processor is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising a processor with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00191] In certain examples, a removable oral device comprising a processor can be used with diuretic. For example, a removable oral device comprising a processor can be used with chlorthalidone (Hygroton). A removable oral device comprising a processor can be used with chlorothiazide (Diruil). A removable oral device comprising a processor can be used with furosemide (Lasix). A removable oral device comprising a processor can be used with hydrochlorothiazide (Esidrix). A removable oral device comprising a processor can be used with indapamide (Lozol). A removable oral device comprising a processor can be used with metolazone (Mykrox).

[00192] In certain instances, a removable oral device comprising a processor can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device comprising a processor can be used with combination diuretics. For example, A removable oral device comprising a processor can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device comprising a processor can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device comprising a processor can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00193] In some instances, a removable oral device comprising a processor can be used with a beta blocker. For example, A removable oral device comprising a processor can be used with acebutolol (Sectral). A removable oral device comprising a processor can be used with atenolol (Tenormin). A removable oral device comprising a processor can be used with betaxolol (Kerlone). A removable oral device comprising a processor can be used with bisoprolol fumarate (Zebeta). A removable oral device comprising a processor can be used with cartelol hydrochloride (Cartrol). A removable oral device comprising a processor can be used with metoprolol tartrate (Lopressor). A removable oral device comprising a processor can be used with metoprolol succinate (Toprol-XL). A removable oral device comprising a processor can be used with nadolol (Corgard). A removable oral device comprising a processor can be used with penbutolol sulfate (Levatol). A removable oral device comprising a processor can be used with pindolol (Visken). A removable oral device comprising a processor can be used with propanolol hydrochloride (Inderal). A removable oral device comprising a processor can be used with solotolol hydrochloride (Betapace). A removable oral device comprising a processor can be used with timolol maleate (Blocadren). A removable oral device comprising a processor can be used with, nebivolol (Bystoliv). A removable oral device comprising a processor can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00194] In some examples, a removable oral device comprising a processor can be used with an acetylcholinesterase inhibitor. For example, a removable oral device comprising a processor can be used with benaxepril hydrochloride (Lotensin). A removable oral device comprising a processor can be used with captopril (Capoten). A removable oral device comprising a processor can be used with enalpril maleate (Vasotec). A removable oral device comprising a processor can be used with fosinopril sodium (Monopril) A removable oral device comprising a processor can be used with lisonopril (Prinivel, Zestril). A removable oral device comprising a processor can be used with moexipril (Univasc). A removable oral device comprising a processor can be used with perindopril (Aceon). A removable oral device comprising a processor can be used with quinapril hydrochloride (Accupril). A removable oral device comprising a processor can be used with ramipril (Altace). A removable oral device comprising a processor can be used with trandolapril (Mavik). [00195] In certain examples, a removable oral device comprising a processor can be used with an angiotensin II receptor blocker. For example, a removable oral device comprising a processor can be used with candesartan (Atacand). A removable oral device comprising a processor can be used with eprosartan mesylate (Teveten). A removable oral device comprising a processor can be used with irbesartan (Avapro). A removable oral device comprising a processor can be used with losartan potassium (Cozaar). A removable oral device comprising a processor can be used with telmisartan (Micardis). A removable oral device comprising a processor can be used with valsartan (Diovan).

[00196] In certain embodiments, a removable oral device comprising a processor can be used with a calcium channel blocker. For example, a removable oral device comprising a processor can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device comprising a processor can be used with bepridil (Vasocor). A removable oral device comprising a processor can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device comprising a processor can be used with felodipine (Plendil). A removable oral device comprising a processor can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device comprising a processor can be used with nicardipine (Cardene SR). A removable oral device comprising a processor can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device comprising a processor can be used with nisoldipine (Sular). A removable oral device comprising a processor can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00197] In certain embodiments, a removable oral device comprising a processor can be used with an alpha blocker. For example, a removable oral device comprising a processor can be used with doxazosin mesylate (Cardura). A removable oral device comprising a processor can be used with prazosin hydrochloride (Minipress). A removable oral device comprising a processor can be used with terazosin hydrochloride (Hytrin).

[00198] In certain embodiments, a removable oral device comprising a processor can be used with an alpha-2-receptor agonist. For example, a removable oral device comprising a processor can be used with methyldopa.

[00199] In certain embodiments, a removable oral device comprising a processor can be used with combined alpha and beta blockers. For example, a removable oral device comprising a processor can be used with carvedilol (Coreg). A removable oral device comprising a processor can be used with labetalol hydrochloride (Normodyne, Trandate).

[00200] In certain embodiments, a removable oral device comprising a processor can be used with a central agonist. For example, a removable oral device comprising a processor can be used with alpha methyldopa (Aldomet). A removable oral device comprising a processor can be used with clonidine hydrochloride (Catapres). A removable oral device comprising a processor can be used with guanabenz acetate (Wytensin). A removable oral device comprising a processor can be used with guanfacine hydrochloride (Tenex).

[00201] In certain embodiments, a removable oral device comprising a processor can be used with a peripheral adrenergic inhibitor. . For example, a removable oral device comprising a processor can be used with guanadrel (Hylorel). A removable oral device comprising a processor can be used with guanethidine monosulfate (Ismelin). A removable oral device comprising a processor can be used with reserpine (Serpasil).

[00202] In certain embodiments, a removable oral device comprising a processor can be used with a blood vessel dilator (vasodilator). For example, a removable oral device comprising a processor can be used with hydralazine hydrocholoride (Apresoline). A removable oral device comprising a processor can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device comprising a processor.

[00203] In some examples, a removable oral device comprising a processor can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device comprising a processor is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising a processor with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00204] In certain examples, a removable oral device comprising a processor can be used with a statin. For example, a removable oral device comprising a processor can be used with an atorvastatin (Lipitor). A removable oral device comprising a processor can be used with a fluvastatin (Lescol). A removable oral device comprising a processor can be used with a rosuvastatin (Crestor). A removable oral device comprising a processor can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device comprising a processor.

[00205] In certain examples, a removable oral device comprising a processor can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device comprising a processor can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device comprising a processor.

[00206] In certain examples, a removable oral device comprising a processor can be used with a resin (bile-acid binding drugs). For example, a removable oral device comprising a processor can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device comprising a processor can be used with colestipol (Colestid®). A removable oral device comprising a processor can be used with colesevelam HCl (WelChol®). If desired, two or more of resins can be used in combination with removable oral device comprising a processor.

[00207] In some examples, a removable oral device comprising a processor can be used with lipid lowering therapies. For example, a removable oral device comprising a processor can be used with gemfibrozil (Lopid®). A removable oral device comprising a processor can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device comprising a processor can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device comprising a processor.

[00208] In some examples, a removable oral device comprising a processor can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device comprising a processor can provide both short term and long term treatment. In some examples, a removable oral device comprising a processor can be used with Abatacept (Orencia). A removable oral device comprising a processor can be used with Adalimumab (Humira). A removable oral device comprising a processor can be used with Adalimumab -atto (Amjevita), a biosimilar to Humira. A removable oral device comprising a processor can be used with Anakinra (Kineret). A removable oral device comprising a processor can be used with Certolizumab pegol (Cimzia). A removable oral device comprising a processor can be used with Etanercept (Enbrel). A removable oral device comprising a processor can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device comprising a processor can be used with Golimumab (Simponi, Simponi Aria). A removable oral device comprising a processor can be used with Infliximab (Remicade). A removable oral device comprising a processor can be used with Infliximab -dyyb (Inflectra), a biosimilar to Remicade. A removable oral device comprising a processor can be used with Rituximab (Rituxan). A removable oral device comprising a processor can be used with Tocilizumab (Actemra). A removable oral device comprising a processor can be used with Tofacitinib (Xeljanz). A removable oral device comprising a processor can be used with Natalizumab (Tysabri). A removable oral device comprising a processor can be used with Secukinumab (Cosentyx). A removable oral device comprising a processor can be used with Ustekinumab (Stelara). A removable oral device comprising a processor can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device comprising a processor. In addition, two or more of the biological agents can be used in combination with removable oral device comprising a processor.

[00209] Combinations Comprising Removable Oral Devices with a Piezoelectric Sensor

[00210] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device which comprises a body comprising a piezoelectric sensor. For example, the removable oral device may comprise a palatal element coupled to a clasping element, in which the palatal element is configured to contact a roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. The body comprises a piezoelectric sensor that is configured to measure movement of the upper jaw or pressure changes if desired. The clasping element is configured to assist in removal of the removable oral device from the mouth.

[00211] Such removable oral devices with a piezoelectric sensor can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with a piezoelectric sensor can be used in combination with one or more medical devices or implants. For example, a removable oral device with a piezoelectric sensor can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with removable oral device comprising a piezoelectric sensor. [00212] In other configurations, a removable oral device comprising a piezoelectric sensor can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with a piezoelectric sensor in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device comprising a piezoelectric sensor.

[00213] In some configurations, the removable oral device comprising a piezoelectric sensor can be used with other medical devices. For example, removable oral device comprising a piezoelectric sensor can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device comprising a piezoelectric sensor can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device comprising a piezoelectric sensor can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device comprising a piezoelectric sensor can be used with a gastric emptying system such as the Aspire assist system. A removable oral device comprising a piezoelectric sensor can be used with a CPAP device. A removable oral device comprising a piezoelectric sensor can be used with a knee implant. A removable oral device comprising a piezoelectric sensor can be used with a hip implant. A removable oral device comprising a piezoelectric sensor can be used with an ankle implant. A removable oral device comprising a piezoelectric sensor can be used with a coronary, venous or arterial stent. A removable oral device comprising a piezoelectric sensor can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device comprising a piezoelectric sensor.

[00214] In other configurations, a removable oral device with a piezoelectric sensor can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device comprising a piezoelectric sensor can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device comprising a piezoelectric sensor can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device comprising a piezoelectric sensor can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device comprising a piezoelectric sensor.

[00215] In other configurations, a removable oral device comprising a piezoelectric sensor can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device comprising a piezoelectric sensor is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a piezoelectric sensor can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device comprising a piezoelectric sensor can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device comprising a piezoelectric sensor can be used with a naltrexone hydrochloride and bupropion hydrochloride extended-release tablet such as the drug commercially marketed as Contrave. A removable oral device comprising a piezoelectric sensor can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide-1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device comprising a piezoelectric sensor can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device comprising a piezoelectric sensor can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device comprising a piezoelectric sensor can be used with a lorcaserin HC1 such as the drug commercially marketed as Belviq. A removable oral device comprising a piezoelectric sensor can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device comprising a piezoelectric sensor can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device comprising a piezoelectric sensor can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device comprising a piezoelectric sensor can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device comprising a piezoelectric sensor can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device comprising a piezoelectric sensor can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device comprising a piezoelectric sensor can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device comprising a piezoelectric sensor can be used with any two or more of the weight loss drugs listed herein.

[00216] In some examples, a removable oral device comprising a piezoelectric sensor can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with a piezoelectric sensor is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a piezoelectric sensor can be used with short acting insulin (Humulin and novolin).

A removable oral device comprising a piezoelectric sensor can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device comprising a piezoelectric sensor can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device comprising a piezoelectric sensor can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device comprising a piezoelectric sensor can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device comprising a piezoelectric sensor can be used with a somatostatin. A removable oral device comprising a piezoelectric sensor can be used with a diazoxide. A removable oral device comprising a piezoelectric sensor can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device comprising a piezoelectric sensor can be used with a dopamine agonist such as bromocriptine. A removable oral device comprising a piezoelectric sensor can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00217] In some instances, a removable oral device comprising a piezoelectric sensor can be used with glucagon like peptides. For example, a removable oral device comprising a piezoelectric sensor can be used with albiglutide (Tanzeum). A removable oral device comprising a piezoelectric sensor can be used with dulaglutide (Trulicity). A removable oral device comprising a piezoelectric sensor can be used with exenetide (Byetta). A removable oral device comprising a piezoelectric sensor can be used with exenatide extended release (Bydureon). A removable oral device comprising a piezoelectric sensor can be used with liraglutide (Victoza). A removable oral device comprising a piezoelectric sensor can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00218] In certain examples, a removable oral device comprising a piezoelectric sensor can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device comprising a piezoelectric sensor can be used with dapagliflozin (Farxiga). A removable oral device comprising a piezoelectric sensor can be used with dapagliflozin- metformin (Xigduo xr). A removable oral device comprising a piezoelectric sensor can be used with carnagliflozin (Invokana). A removable oral device comprising a piezoelectric sensor can be used with canagliflozin-metformin (Invokamet). A removable oral device comprising a piezoelectric sensor can be used with empagliflozin (Jardiance). A removable oral device comprising a piezoelectric sensor can be used with empagliflozin-linagliptin (Glyxambi). [00219] In other examples, a removable oral device comprising a piezoelectric sensor can be used with a sulfonylurea. For example, a removable oral device comprising a piezoelectric sensor can be used with glimepiride (Amaryl). A removable oral device comprising a piezoelectric sensor can be used with glimepride-pioglitazone (Duotact). A removable oral device comprising a piezoelectric sensor can be used with glimepiride-rosiglitazone (Avendary). A removable oral device comprising a piezoelectric sensor can be used with gliclazide, glipizide (Glucotrol). A removable oral device comprising a piezoelectric sensor can be used with glipizide-metformin (Metaglip). A removable oral device comprising a piezoelectric sensor can be used with glyburide (Diabets, glynase, Micronase). A removable oral device comprising a piezoelectric sensor can be used with chloropropamide (Diabinese). A removable oral device comprising a piezoelectric sensor can be used with tolazamide (Tolinase). A removable oral device comprising a piezoelectric sensor can be used with tolbutamide (Orinase, tol-tab).

[00220] In some instances, a removable oral device comprising a piezoelectric sensor can be used with a thiazolidinedione. For example, a removable oral device comprising a piezoelectric sensor can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device comprising a piezoelectric sensor can be used with rosiglitazone-metformin (Amaryl M). A removable oral device comprising a piezoelectric sensor can be used with pioglitazone (Actos). A removable oral device comprising a piezoelectric sensor can be used with pioglitazone-alogliptin (Oseni), A removable oral device comprising a piezoelectric sensor can be used with pilglitazone-glimepride (Duetact). A removable oral device comprising a piezoelectric sensor can be used with pioglitazone- metformin (Actoplus met, Actoplus met xr). A removable oral device comprising a piezoelectric sensor can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device comprising a piezoelectric sensor can be used with a glucagon. If desired, a removable oral device comprising a piezoelectric sensor can be used with any two, three or more of the diabetes drugs listed herein.

[00221] In some instances, a removable oral device comprising a piezoelectric sensor can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device comprising a piezoelectric sensor is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising a piezoelectric sensor with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss. [00222] In certain examples, a removable oral device comprising a piezoelectric sensor can be used with diuretic. For example, a removable oral device comprising a piezoelectric sensor can be used with chlorthalidone (Hygroton). A removable oral device comprising a piezoelectric sensor can be used with chlorothiazide (Diruil). A removable oral device comprising a piezoelectric sensor can be used with furosemide (Lasix). A removable oral device comprising a piezoelectric sensor can be used with hydrochlorothiazide (Esidrix). A removable oral device comprising a piezoelectric sensor can be used with indapamide (Lozol). A removable oral device comprising a piezoelectric sensor can be used with metolazone (Mykrox).

[00223] In certain instances, a removable oral device comprising a piezoelectric sensor can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device comprising a piezoelectric sensor can be used with combination diuretics. For example, A removable oral device comprising a piezoelectric sensor can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device comprising a piezoelectric sensor can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device comprising a piezoelectric sensor can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00224] In some instances, a removable oral device comprising a piezoelectric sensor can be used with a beta blocker. For example, A removable oral device comprising a piezoelectric sensor can be used with acebutolol (Sectral). A removable oral device comprising a piezoelectric sensor can be used with atenolol (Tenormin). A removable oral device comprising a piezoelectric sensor can be used with betaxolol (Kerlone). A removable oral device comprising a piezoelectric sensor can be used with bisoprolol fumarate (Zebeta). A removable oral device comprising a piezoelectric sensor can be used with cartelol hydrochloride (Cartrol). A removable oral device comprising a piezoelectric sensor can be used with metoprolol tartrate (Lopressor). A removable oral device comprising a piezoelectric sensor can be used with metoprolol succinate (Toprol-XL). A removable oral device comprising a piezoelectric sensor can be used with nadolol (Corgard). A removable oral device comprising a piezoelectric sensor can be used with penbutolol sulfate (Levatol). A removable oral device comprising a piezoelectric sensor can be used with pindolol (Visken). A removable oral device comprising a piezoelectric sensor can be used with propanolol hydrochloride (Inderal). A removable oral device comprising a piezoelectric sensor can be used with solotolol hydrochloride (Betapace). A removable oral device comprising a piezoelectric sensor can be used with timolol maleate (Blocadren). A removable oral device comprising a piezoelectric sensor can be used with, nebivolol (Bystoliv). A removable oral device comprising a piezoelectric sensor can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac). [00225] In some examples, a removable oral device comprising a piezoelectric sensor can be used with an acetylcholinesterase inhibitor. For example, a removable oral device comprising a piezoelectric sensor can be used with benaxepril hydrochloride (Lotensin). A removable oral device comprising a piezoelectric sensor can be used with captopril (Capoten). A removable oral device comprising a piezoelectric sensor can be used with enalpril maleate (Vasotec). A removable oral device comprising a piezoelectric sensor can be used with fosinopril sodium (Monopril) A removable oral device comprising a piezoelectric sensor can be used with lisonopril (Prinivel, Zestril). A removable oral device comprising a piezoelectric sensor can be used with moexipril (Univasc). A removable oral device comprising a piezoelectric sensor can be used with perindopril (Aceon). A removable oral device comprising a piezoelectric sensor can be used with quinapril hydrochloride (Accupril). A removable oral device comprising a piezoelectric sensor can be used with ramipril (Altace). A removable oral device comprising a piezoelectric sensor can be used with trandolapril (Mavik).

[00226] In certain examples, a removable oral device comprising a piezoelectric sensor can be used with an angiotensin II receptor blocker. For example, a removable oral device comprising a piezoelectric sensor can be used with candesartan (Atacand). A removable oral device comprising a piezoelectric sensor can be used with eprosartan mesylate (Teveten). A removable oral device comprising a piezoelectric sensor can be used with irbesartan (Avapro). A removable oral device comprising a piezoelectric sensor can be used with losartan potassium (Cozaar). A removable oral device comprising a piezoelectric sensor can be used with telmisartan (Micardis). A removable oral device comprising a piezoelectric sensor can be used with valsartan (Diovan).

[00227] In certain embodiments, a removable oral device comprising a piezoelectric sensor can be used with a calcium channel blocker. For example, a removable oral device comprising a piezoelectric sensor can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device comprising a piezoelectric sensor can be used with bepridil (Vasocor). A removable oral device comprising a piezoelectric sensor can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device comprising a piezoelectric sensor can be used with felodipine (Plendil). A removable oral device comprising a piezoelectric sensor can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device comprising a piezoelectric sensor can be used with nicardipine (Cardene SR). A removable oral device comprising a piezoelectric sensor can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device comprising a piezoelectric sensor can be used with nisoldipine (Sular). A removable oral device comprising a piezoelectric sensor can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan). [00228] In certain embodiments, a removable oral device comprising a piezoelectric sensor can be used with an alpha blocker. For example, a removable oral device comprising a piezoelectric sensor can be used with doxazosin mesylate (Cardura). A removable oral device comprising a piezoelectric sensor can be used with prazosin hydrochloride (Minipress). A removable oral device comprising a piezoelectric sensor can be used with terazosin hydrochloride (Hytrin).

[00229] In certain embodiments, a removable oral device comprising a piezoelectric sensor can be used with an alpha-2-receptor agonist. For example, a removable oral device comprising a piezoelectric sensor can be used with methyldopa.

[00230] In certain embodiments, a removable oral device comprising a piezoelectric sensor can be used with combined alpha and beta blockers. For example, a removable oral device comprising a piezoelectric sensor can be used with carvedilol (Coreg). A removable oral device comprising a piezoelectric sensor can be used with labetalol hydrochloride (Normodyne, Trandate).

[00231] In certain embodiments, a removable oral device comprising a piezoelectric sensor can be used with a central agonist. For example, a removable oral device comprising a piezoelectric sensor can be used with alpha methyldopa (Aldomet). A removable oral device comprising a piezoelectric sensor can be used with clonidine hydrochloride (Catapres). A removable oral device comprising a piezoelectric sensor can be used with guanabenz acetate (Wytensin). A removable oral device comprising a piezoelectric sensor can be used with guanfacine hydrochloride (Tenex).

[00232] In certain embodiments, a removable oral device comprising a piezoelectric sensor can be used with a peripheral adrenergic inhibitor. . For example, a removable oral device comprising a piezoelectric sensor can be used with guanadrel (Hylorel). A removable oral device comprising a piezoelectric sensor can be used with guanethidine monosulfate (Ismelin). A removable oral device comprising a piezoelectric sensor can be used with reserpine (Serpasil).

[00233] In certain embodiments, a removable oral device comprising a piezoelectric sensor can be used with a blood vessel dilator (vasodilator). For example, a removable oral device comprising a piezoelectric sensor can be used with hydralazine hydrocholoride (Apresoline). A removable oral device comprising a piezoelectric sensor can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device comprising a piezoelectric sensor.

[00234] In some examples, a removable oral device comprising a piezoelectric sensor can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device comprising a piezoelectric sensor is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising a piezoelectric sensor with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00235] In certain examples, a removable oral device comprising a piezoelectric sensor can be used with a statin. For example, a removable oral device comprising a piezoelectric sensor can be used with an atorvastatin (Lipitor). A removable oral device comprising a piezoelectric sensor can be used with a fluvastatin (Lescol). A removable oral device comprising a piezoelectric sensor can be used with a rosuvastatin (Crestor). A removable oral device comprising a piezoelectric sensor can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device comprising a piezoelectric sensor.

[00236] In certain examples, a removable oral device comprising a piezoelectric sensor can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device comprising a piezoelectric sensor can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device comprising a piezoelectric sensor.

[00237] In certain examples, a removable oral device comprising a piezoelectric sensor can be used with a resin (bile-acid binding drugs). For example, a removable oral device comprising a piezoelectric sensor can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device comprising a piezoelectric sensor can be used with colestipol (Colestid®). A removable oral device comprising a piezoelectric sensor can be used with colesevelam HC1 (WelChol®). If desired, two or more of resins can be used in combination with removable oral device comprising a piezoelectric sensor.

[00238] In some examples, a removable oral device comprising a piezoelectric sensor can be used with lipid lowering therapies. For example, a removable oral device comprising a piezoelectric sensor can be used with gemfibrozil (Lopid®). A removable oral device comprising a piezoelectric sensor can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device comprising a piezoelectric sensor can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device comprising a piezoelectric sensor.

[00239] In some examples, a removable oral device comprising a piezoelectric sensor can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device comprising a piezoelectric sensor can provide both short term and long term treatment. In some examples, a removable oral device comprising a piezoelectric sensor can be used with Abatacept (Orencia). A removable oral device comprising a piezoelectric sensor can be used with Adalimumab (Humira). A removable oral device comprising a piezoelectric sensor can be used with Adalimumab -atto (Amjevita), a biosimilar to Humira. A removable oral device comprising a piezoelectric sensor can be used with Anakinra (Kineret). A removable oral device comprising a piezoelectric sensor can be used with Certolizumab pegol (Cimzia). A removable oral device comprising a piezoelectric sensor can be used with Etanercept (Enbrel). A removable oral device comprising a piezoelectric sensor can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device comprising a piezoelectric sensor can be used with Golimumab (Simponi, Simponi Aria). A removable oral device comprising a piezoelectric sensor can be used with Infliximab (Remicade). A removable oral device comprising a piezoelectric sensor can be used with Infliximab-dyyb (Inflectra), a biosimilar to Remicade. A removable oral device comprising a piezoelectric sensor can be used with Rituximab (Rituxan). A removable oral device comprising a piezoelectric sensor can be used with Tocilizumab (Actemra). A removable oral device comprising a piezoelectric sensor can be used with Tofacitinib (Xeljanz). A removable oral device comprising a piezoelectric sensor can be used with Natalizumab (Tysabri). A removable oral device comprising a piezoelectric sensor can be used with Secukinumab (Cosentyx). A removable oral device comprising a piezoelectric sensor can be used with Ustekinumab (Stelara). A removable oral device comprising a piezoelectric sensor can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device comprising a piezoelectric sensor. In addition, two or more of the biological agents can be used in combination with a removable oral device comprising a piezoelectric sensor.

[00240] Combinations Comprising Removable Oral Devices with an Accelerometer [00241] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device which comprises a body comprising an accelerometer. For example, the removable oral device may comprise a palatal element coupled to a clasping element, in which the palatal element is configured to contact a roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. The body comprises an accelerometer that is configured to measure impact force or be used to monitor head movement as a measure of impact force. The clasping element is configured to assist in removal of the removable oral device from the mouth.

[00242] Such removable oral devices with an accelerometer can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with an accelerometer can be used in combination with one or more medical devices or implants. For example, a removable oral device with an accelerometer can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with removable oral device comprising an accelerometer.

[00243] In other configurations, a removable oral device comprising an accelerometer can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with an accelerometer in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device comprising an accelerometer.

[00244] In some configurations, the removable oral device comprising an accelerometer can be used with other medical devices. For example, removable oral device comprising an accelerometer can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device comprising an accelerometer can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device comprising an accelerometer can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device comprising an accelerometer can be used with a gastric emptying system such as the Aspire assist system. A removable oral device comprising an accelerometer can be used with a CPAP device. A removable oral device comprising an accelerometer can be used with a knee implant. A removable oral device comprising an accelerometer can be used with a hip implant. A removable oral device comprising an accelerometer can be used with an ankle implant. A removable oral device comprising an accelerometer can be used with a coronary, venous or arterial stent. A removable oral device comprising an accelerometer can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device comprising an accelerometer.

[00245] In other configurations, a removable oral device with an accelerometer can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device comprising an accelerometer can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device comprising an accelerometer can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device comprising an accelerometer can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device comprising an accelerometer.

[00246] In other configurations, a removable oral device comprising an accelerometer can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device comprising an accelerometer is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising an accelerometer can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device comprising an accelerometer can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device comprising an accelerometer can be used with a naltrexone hydrochloride and bupropion hydrochloride extended-release tablet such as the drug commercially marketed as Contrave. A removable oral device comprising an accelerometer can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide-1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device comprising an accelerometer can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device comprising an accelerometer can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device comprising an accelerometer can be used with a lorcaserin HC1 such as the drug commercially marketed as Belviq. A removable oral device comprising an accelerometer can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device comprising an accelerometer can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device comprising an accelerometer can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device comprising an accelerometer can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device comprising an accelerometer can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device comprising an accelerometer can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device comprising an accelerometer can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device comprising an accelerometer can be used with any two or more of the weight loss drugs listed herein.

[00247] In some examples, a removable oral device comprising an accelerometer can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with an accelerometer is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising an accelerometer can be used with short acting insulin (Humulin and novolin). A removable oral device comprising an accelerometer can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device comprising an accelerometer can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device comprising an accelerometer can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device comprising an accelerometer can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device comprising an accelerometer can be used with a somatostatin. A removable oral device comprising an accelerometer can be used with a diazoxide. A removable oral device comprising an accelerometer can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device comprising an accelerometer can be used with a dopamine agonist such as bromocriptine. A removable oral device comprising an accelerometer can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00248] In some instances, a removable oral device comprising an accelerometer can be used with glucagon like peptides. For example, a removable oral device comprising an accelerometer can be used with albiglutide (Tanzeum). A removable oral device comprising an accelerometer can be used with dulaglutide (Trulicity). A removable oral device comprising an accelerometer can be used with exenetide (Byetta). A removable oral device comprising an accelerometer can be used with exenatide extended release (Bydureon). A removable oral device comprising an accelerometer can be used with liraglutide (Victoza). A removable oral device comprising an accelerometer can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00249] In certain examples, a removable oral device comprising an accelerometer can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device comprising an accelerometer can be used with dapagliflozin (Farxiga). A removable oral device comprising an accelerometer can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device comprising an accelerometer can be used with carnagliflozin (Invokana). A removable oral device comprising an accelerometer can be used with canagliflozin-metformin (Invokamet). A removable oral device comprising an accelerometer can be used with empagliflozin (Jardiance). A removable oral device comprising an accelerometer can be used with empagliflozin-linagliptin (Glyxambi).

[00250] In other examples, a removable oral device comprising an accelerometer can be used with a sulfonylurea. For example, a removable oral device comprising an accelerometer can be used with glimepiride (Amaryl). A removable oral device comprising an accelerometer can be used with glimepride-pioglitazone (Duotact). A removable oral device comprising an accelerometer can be used with glimepiride-rosiglitazone (Avendary). A removable oral device comprising an accelerometer can be used with gliclazide, glipizide (Glucotrol). A removable oral device comprising an accelerometer can be used with glipizide-metformin (Metaglip). A removable oral device comprising an accelerometer can be used with glyburide (Diabets, glynase, Micronase). A removable oral device comprising an accelerometer can be used with chloropropamide (Diabinese). A removable oral device comprising an accelerometer can be used with tolazamide (Tolinase). A removable oral device comprising an accelerometer can be used with tolbutamide (Orinase, tol-tab).

[00251] In some instances, a removable oral device comprising an accelerometer can be used with a thiazolidinedione. For example, a removable oral device comprising an accelerometer can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device comprising an accelerometer can be used with rosiglitazone-metformin (Amaryl M). A removable oral device comprising an accelerometer can be used with pioglitazone (Actos). A removable oral device comprising an accelerometer can be used with pioglitazone-alogliptin (Oseni), A removable oral device comprising an accelerometer can be used with pilglitazone-glimepride (Duetact). A removable oral device comprising an accelerometer can be used with pioglitazone-metformin (Actoplus met, Actoplus met xr). A removable oral device comprising an accelerometer can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device comprising an accelerometer can be used with a glucagon. If desired, a removable oral device comprising an accelerometer can be used with any two, three or more of the diabetes drugs listed herein.

[00252] In some instances, a removable oral device comprising an accelerometer can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device comprising an accelerometer is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising an accelerometer with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00253] In certain examples, a removable oral device comprising an accelerometer can be used with diuretic. For example, a removable oral device comprising an accelerometer can be used with chlorthalidone (Hygroton). A removable oral device comprising an accelerometer can be used with chlorothiazide (Diruil). A removable oral device comprising an accelerometer can be used with furosemide (Lasix). A removable oral device comprising an accelerometer can be used with hydrochlorothiazide (Esidrix). A removable oral device comprising an accelerometer can be used with indapamide (Lozol). A removable oral device comprising an accelerometer can be used with metolazone (Mykrox).

[00254] In certain instances, a removable oral device comprising an accelerometer can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device comprising an accelerometer can be used with combination diuretics. For example, A removable oral device comprising an accelerometer can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device comprising an accelerometer can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device comprising an accelerometer can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide). [00255] In some instances, a removable oral device comprising an accelerometer can be used with a beta blocker. For example, A removable oral device comprising an accelerometer can be used with acebutolol (Sectral). A removable oral device comprising an accelerometer can be used with atenolol (Tenormin). A removable oral device comprising an accelerometer can be used with betaxolol (Kerlone). A removable oral device comprising an accelerometer can be used with bisoprolol fumarate (Zebeta). A removable oral device comprising an accelerometer can be used with cartelol hydrochloride (Cartrol). A removable oral device comprising an accelerometer can be used with metoprolol tartrate (Lopressor). A removable oral device comprising an accelerometer can be used with metoprolol succinate (Toprol-XL). A removable oral device comprising an accelerometer can be used with nadolol (Corgard). A removable oral device comprising an accelerometer can be used with penbutolol sulfate (Levatol). A removable oral device comprising an accelerometer can be used with pindolol (Visken). A removable oral device comprising an accelerometer can be used with propanolol hydrochloride (Inderal). A removable oral device comprising an accelerometer can be used with solotolol hydrochloride (Betapace). A removable oral device comprising an accelerometer can be used with timolol maleate (Blocadren). A removable oral device comprising an accelerometer can be used with, nebivolol (Bystoliv). A removable oral device comprising an accelerometer can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00256] In some examples, a removable oral device comprising an accelerometer can be used with an acetylcholinesterase inhibitor. For example, a removable oral device comprising an accelerometer can be used with benaxepril hydrochloride (Lotensin). A removable oral device comprising an accelerometer can be used with captopril (Capoten). A removable oral device comprising an accelerometer can be used with enalpril maleate (Vasotec). A removable oral device comprising an accelerometer can be used with fosinopril sodium (Monopril) A removable oral device comprising an accelerometer can be used with lisonopril (Prinivel, Zestril). A removable oral device comprising an accelerometer can be used with moexipril (Univasc). A removable oral device comprising an accelerometer can be used with perindopril (Aceon). A removable oral device comprising an accelerometer can be used with quinapril hydrochloride (Accupril). A removable oral device comprising an accelerometer can be used with ramipril (Altace). A removable oral device comprising an accelerometer can be used with trandolapril (Mavik).

[00257] In certain examples, a removable oral device comprising an accelerometer can be used with an angiotensin II receptor blocker. For example, a removable oral device comprising an accelerometer can be used with candesartan (Atacand). A removable oral device comprising an accelerometer can be used with eprosartan mesylate (Teveten). A removable oral device comprising an accelerometer can be used with irbesartan (Avapro). A removable oral device comprising an accelerometer can be used with losartan potassium (Cozaar). A removable oral device comprising an accelerometer can be used with telmisartan (Micardis). A removable oral device comprising an accelerometer can be used with valsartan (Diovan).

[00258] In certain embodiments, a removable oral device comprising an accelerometer can be used with a calcium channel blocker. For example, a removable oral device comprising an accelerometer can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device comprising an accelerometer can be used with bepridil (Vasocor). A removable oral device comprising an accelerometer can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device comprising an accelerometer can be used with felodipine (Plendil). A removable oral device comprising an accelerometer can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device comprising an accelerometer can be used with nicardipine (Cardene SR). A removable oral device comprising an accelerometer can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device comprising an accelerometer can be used with nisoldipine (Sular). A removable oral device comprising an accelerometer can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00259] In certain embodiments, a removable oral device comprising an accelerometer can be used with an alpha blocker. For example, a removable oral device comprising an accelerometer can be used with doxazosin mesylate (Cardura). A removable oral device comprising an accelerometer can be used with prazosin hydrochloride (Minipress). A removable oral device comprising an accelerometer can be used with terazosin hydrochloride (Hytrin).

[00260] In certain embodiments, a removable oral device comprising an accelerometer can be used with an alpha-2-receptor agonist. For example, a removable oral device comprising an accelerometer can be used with methyldopa.

[00261] In certain embodiments, a removable oral device comprising an accelerometer can be used with combined alpha and beta blockers. For example, a removable oral device comprising an accelerometer can be used with carvedilol (Coreg). A removable oral device comprising an accelerometer can be used with labetalol hydrochloride (Normodyne, Trandate).

[00262] In certain embodiments, a removable oral device comprising an accelerometer can be used with a central agonist. For example, a removable oral device comprising an accelerometer can be used with alpha methyldopa (Aldomet). A removable oral device comprising an accelerometer can be used with clonidine hydrochloride (Catapres). A removable oral device comprising an accelerometer can be used with guanabenz acetate (Wytensin). A removable oral device comprising an accelerometer can be used with guanfacine hydrochloride (Tenex).

[00263] In certain embodiments, a removable oral device comprising an accelerometer can be used with a peripheral adrenergic inhibitor. For example, a removable oral device comprising an accelerometer can be used with guanadrel (Hylorel). A removable oral device comprising an accelerometer can be used with guanethidine monosulfate (Ismelin). A removable oral device comprising an accelerometer can be used with reserpine (Serpasil).

[00264] In certain embodiments, a removable oral device comprising an accelerometer can be used with a blood vessel dilator (vasodilator). For example, a removable oral device comprising an accelerometer can be used with hydralazine hydrocholoride (Apresoline). A removable oral device comprising an accelerometer can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device comprising an accelerometer.

[00265] In some examples, a removable oral device comprising an accelerometer can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device comprising an accelerometer is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising an accelerometer with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00266] In certain examples, a removable oral device comprising an accelerometer can be used with a statin. For example, a removable oral device comprising an accelerometer can be used with an atorvastatin (Lipitor). A removable oral device comprising an accelerometer can be used with a fluvastatin (Lescol). A removable oral device comprising an accelerometer can be used with a rosuvastatin (Crestor). A removable oral device comprising an accelerometer can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device comprising an accelerometer.

[00267] In certain examples, a removable oral device comprising an accelerometer can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device comprising an accelerometer can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device comprising an accelerometer.

[00268] In certain examples, a removable oral device comprising an accelerometer can be used with a resin (bile-acid binding drugs). For example, a removable oral device comprising an accelerometer can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device comprising an accelerometer can be used with colestipol (Colestid®). A removable oral device comprising an accelerometer can be used with colesevelam HC1 (WelChol®). If desired, two or more of resins can be used in combination with removable oral device comprising an accelerometer.

[00269] In some examples, a removable oral device comprising an accelerometer can be used with lipid lowering therapies. For example, a removable oral device comprising an accelerometer can be used with gemfibrozil (Lopid®). A removable oral device comprising an accelerometer can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device comprising an accelerometer can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device comprising an accelerometer.

[00270] In some examples, a removable oral device comprising an accelerometer can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device comprising an accelerometer can provide both short term and long term treatment. In some examples, a removable oral device comprising an accelerometer can be used with Abatacept (Orencia). A removable oral device comprising an accelerometer can be used with Adalimumab (Humira). A removable oral device comprising an accelerometer can be used with Adalimumab-atto (Amjevita), a biosimilar to Humira. A removable oral device comprising an accelerometer can be used with Anakinra (Kineret). A removable oral device comprising an accelerometer can be used with Certolizumab pegol (Cimzia). A removable oral device comprising an accelerometer can be used with Etanercept (Enbrel). A removable oral device comprising an accelerometer can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device comprising an accelerometer can be used with Golimumab (Simponi, Simponi Aria). A removable oral device comprising an accelerometer can be used with Infliximab (Remicade). A removable oral device comprising an accelerometer can be used with Infliximab-dyyb (Inflectra), a biosimilar to Remicade. A removable oral device comprising an accelerometer can be used with Rituximab (Rituxan). A removable oral device comprising an accelerometer can be used with Tocilizumab (Actemra). A removable oral device comprising an accelerometer can be used with Tofacitinib (Xeljanz). A removable oral device comprising an accelerometer can be used with Natalizumab (Tysabri). A removable oral device comprising an accelerometer can be used with Secukinumab (Cosentyx). A removable oral device comprising an accelerometer can be used with Ustekinumab (Stelara). A removable oral device comprising an accelerometer can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device comprising an accelerometer. In addition, two or more of the biological agents can be used in combination with a removable oral device comprising an accelerometer.

[00271] Combinations Comprising Removable Oral Devices with an Electrode Configured to Determine Body Fat Percentage

[00272] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device which comprises a body comprising an electrode. For example, the removable oral device may comprise a palatal element coupled to a clasping element, in which the palatal element is configured to contact a roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. The body comprises an electrode that is configured to determine a body fat percentage of a user, e.g., using bioelectrical impedance or other methods. The clasping element is configured to assist in removal of the removable oral device from the mouth.

[00273] Such removable oral devices with an electrode can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with an electrode can be used in combination with one or more medical devices or implants. For example, a removable oral device with an electrode can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with removable oral device comprising an electrode. [00274] In other configurations, a removable oral device comprising an electrode can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with an electrode in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device comprising an electrode.

[00275] In some configurations, the removable oral device comprising an electrode can be used with other medical devices. For example, removable oral device comprising an electrode can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device comprising an electrode can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device comprising an electrode can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device comprising an electrode can be used with a gastric emptying system such as the Aspire assist system. A removable oral device comprising an electrode can be used with a CPAP device. A removable oral device comprising an electrode can be used with a knee implant. A removable oral device comprising an electrode can be used with a hip implant. A removable oral device comprising an electrode can be used with an ankle implant. A removable oral device comprising an electrode can be used with a coronary, venous or arterial stent. A removable oral device comprising an electrode can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device comprising an electrode.

[00276] In other configurations, a removable oral device with an electrode can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device comprising an electrode can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device comprising an electrode can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device comprising an electrode can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device comprising an electrode.

[00277] In other configurations, a removable oral device comprising an electrode can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device comprising an electrode is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising an electrode can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device comprising an electrode can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device comprising an electrode can be used with a naltrexone hydrochloride and bupropion hydrochloride extended- release tablet such as the drug commercially marketed as Contrave. A removable oral device comprising an electrode can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide-1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device comprising an electrode can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device comprising an electrode can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device comprising an electrode can be used with a lorcaserin HC1 such as the drug commercially marketed as Belviq. A removable oral device comprising an electrode can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device comprising an electrode can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device comprising an electrode can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device comprising an electrode can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device comprising an electrode can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device comprising an electrode can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device comprising an electrode can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device comprising an electrode can be used with any two or more of the weight loss drugs listed herein.

[00278] In some examples, a removable oral device comprising an electrode can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with an electrode is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising an electrode can be used with short acting insulin (Humulin and novolin). A removable oral device comprising an electrode can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device comprising an electrode can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as

Humalin N, Novolin N. A removable oral device comprising an electrode can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin

Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device comprising an electrode can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device comprising an electrode can be used with a somatostatin. A removable oral device comprising an electrode can be used with a diazoxide. A removable oral device comprising an electrode can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device comprising an electrode can be used with a dopamine agonist such as bromocriptine. A removable oral device comprising an electrode can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00279] In some instances, a removable oral device comprising an electrode can be used with glucagon like peptides. For example, a removable oral device comprising an electrode can be used with albiglutide (Tanzeum). A removable oral device comprising an electrode can be used with dulaglutide (Trulicity). A removable oral device comprising an electrode can be used with exenetide (Byetta). A removable oral device comprising an electrode can be used with exenatide extended release (Bydureon). A removable oral device comprising an electrode can be used with liraglutide (Victoza). A removable oral device comprising an electrode can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00280] In certain examples, a removable oral device comprising an electrode can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device comprising an electrode can be used with dapagliflozin (Farxiga). A removable oral device comprising an electrode can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device comprising an electrode can be used with carnagliflozin (Invokana). A removable oral device comprising an electrode can be used with canagliflozin-metformin (Invokamet). A removable oral device comprising an electrode can be used with empagliflozin (Jardiance). A removable oral device comprising an electrode can be used with empagliflozin-linagliptin (Glyxambi).

[00281] In other examples, a removable oral device comprising an electrode can be used with a sulfonylurea. For example, a removable oral device comprising an electrode can be used with glimepiride (Amaryl). A removable oral device comprising an electrode can be used with glimepride-pioglitazone (Duotact). A removable oral device comprising an electrode can be used with glimepiride-rosiglitazone (Avendary). A removable oral device comprising an electrode can be used with gliclazide, glipizide (Glucotrol). A removable oral device comprising an electrode can be used with glipizide-metformin (Metaglip). A removable oral device comprising an electrode can be used with glyburide (Diabets, glynase, Micronase). A removable oral device comprising an electrode can be used with chloropropamide (Diabinese). A removable oral device comprising an electrode can be used with tolazamide (Tolinase). A removable oral device comprising an electrode can be used with tolbutamide (Orinase, tol-tab).

[00282] In some instances, a removable oral device comprising an electrode can be used with a thiazolidinedione. For example, a removable oral device comprising an electrode can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device comprising an electrode can be used with rosiglitazone-metformin (Amaryl M). A removable oral device comprising an electrode can be used with pioglitazone (Actos). A removable oral device comprising an electrode can be used with pioglitazone-alogliptin (Oseni), A removable oral device comprising an electrode can be used with pilglitazone-glimepride (Duetact). A removable oral device comprising an electrode can be used with pioglitazone- metformin (Actoplus met, Actoplus met xr). A removable oral device comprising an electrode can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device comprising an electrode can be used with a glucagon. If desired, a removable oral device comprising an electrode can be used with any two, three or more of the diabetes drugs listed herein.

[00283] In some instances, a removable oral device comprising an electrode can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device comprising an electrode is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising an electrode with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00284] In certain examples, a removable oral device comprising an electrode can be used with diuretic. For example, a removable oral device comprising an electrode can be used with chlorthalidone (Hygroton). A removable oral device comprising an electrode can be used with chlorothiazide (Diruil). A removable oral device comprising an electrode can be used with furosemide (Lasix). A removable oral device comprising an electrode can be used with hydrochlorothiazide (Esidrix). A removable oral device comprising an electrode can be used with indapamide (Lozol). A removable oral device comprising an electrode can be used with metolazone (Mykrox). [00285] In certain instances, a removable oral device comprising an electrode can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device comprising an electrode can be used with combination diuretics. For example, A removable oral device comprising an electrode can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device comprising an electrode can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device comprising an electrode can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00286] In some instances, a removable oral device comprising an electrode can be used with a beta blocker. For example, A removable oral device comprising an electrode can be used with acebutolol (Sectral). A removable oral device comprising an electrode can be used with atenolol (Tenormin). A removable oral device comprising an electrode can be used with betaxolol (Kerlone). A removable oral device comprising an electrode can be used with bisoprolol fumarate (Zebeta). A removable oral device comprising an electrode can be used with cartelol hydrochloride (Cartrol). A removable oral device comprising an electrode can be used with metoprolol tartrate (Lopressor). A removable oral device comprising an electrode can be used with metoprolol succinate (Toprol-XL). A removable oral device comprising an electrode can be used with nadolol (Corgard). A removable oral device comprising an electrode can be used with penbutolol sulfate (Levatol). A removable oral device comprising an electrode can be used with pindolol (Visken). A removable oral device comprising an electrode can be used with propanolol hydrochloride (Inderal). A removable oral device comprising an electrode can be used with solotolol hydrochloride (Betapace). A removable oral device comprising an electrode can be used with timolol maleate (Blocadren). A removable oral device comprising an electrode can be used with, nebivolol (Bystoliv). A removable oral device comprising an electrode can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00287] In some examples, a removable oral device comprising an electrode can be used with an acetylcholinesterase inhibitor. For example, a removable oral device comprising an electrode can be used with benaxepril hydrochloride (Lotensin). A removable oral device comprising an electrode can be used with captopril (Capoten). A removable oral device comprising an electrode can be used with enalpril maleate (Vasotec). A removable oral device comprising an electrode can be used with fosinopril sodium (Monopril) A removable oral device comprising an electrode can be used with lisonopril (Prinivel, Zestril). A removable oral device comprising an electrode can be used with moexipril (Univasc). A removable oral device comprising an electrode can be used with perindopril (Aceon). A removable oral device comprising an electrode can be used with quinapril hydrochloride (Accupril). A removable oral device comprising an electrode can be used with ramipril (Altace). A removable oral device comprising an electrode can be used with trandolapril (Mavik).

[00288] In certain examples, a removable oral device comprising an electrode can be used with an angiotensin II receptor blocker. For example, a removable oral device comprising an electrode can be used with candesartan (Atacand). A removable oral device comprising an electrode can be used with eprosartan mesylate (Teveten). A removable oral device comprising an electrode can be used with irbesartan (Avapro). A removable oral device comprising an electrode can be used with losartan potassium (Cozaar). A removable oral device comprising an electrode can be used with telmisartan (Micardis). A removable oral device comprising an electrode can be used with valsartan (Diovan).

[00289] In certain embodiments, a removable oral device comprising an electrode can be used with a calcium channel blocker. For example, a removable oral device comprising an electrode can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device comprising an electrode can be used with bepridil (Vasocor). A removable oral device comprising an electrode can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device comprising an electrode can be used with felodipine (Plendil). A removable oral device comprising an electrode can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device comprising an electrode can be used with nicardipine (Cardene SR). A removable oral device comprising an electrode can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device comprising an electrode can be used with nisoldipine (Sular). A removable oral device comprising an electrode can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00290] In certain embodiments, a removable oral device comprising an electrode can be used with an alpha blocker. For example, a removable oral device comprising an electrode can be used with doxazosin mesylate (Cardura). A removable oral device comprising an electrode can be used with prazosin hydrochloride (Minipress). A removable oral device comprising an electrode can be used with terazosin hydrochloride (Hytrin).

[00291] In certain embodiments, a removable oral device comprising an electrode can be used with an alpha-2-receptor agonist. For example, a removable oral device comprising an electrode can be used with methyldopa.

[00292] In certain embodiments, a removable oral device comprising an electrode can be used with combined alpha and beta blockers. For example, a removable oral device comprising an electrode can be used with carvedilol (Coreg). A removable oral device comprising an electrode can be used with labetalol hydrochloride (Normodyne, Trandate). [00293] In certain embodiments, a removable oral device comprising an electrode can be used with a central agonist. For example, a removable oral device comprising an electrode can be used with alpha methyldopa (Aldomet). A removable oral device comprising an electrode can be used with clonidine hydrochloride (Catapres). A removable oral device comprising an electrode can be used with guanabenz acetate (Wytensin). A removable oral device comprising an electrode can be used with guanfacine hydrochloride (Tenex).

[00294] In certain embodiments, a removable oral device comprising an electrode can be used with a peripheral adrenergic inhibitor. . For example, a removable oral device comprising an electrode can be used with guanadrel (Hylorel). A removable oral device comprising an electrode can be used with guanethidine monosulfate (Ismelin). A removable oral device comprising an electrode can be used with reserpine (Serpasil).

[00295] In certain embodiments, a removable oral device comprising an electrode can be used with a blood vessel dilator (vasodilator). For example, a removable oral device comprising an electrode can be used with hydralazine hydrocholoride (Apresoline). A removable oral device comprising an electrode can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device comprising an electrode.

[00296] In some examples, a removable oral device comprising an electrode can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device comprising an electrode is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising an electrode with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00297] In certain examples, a removable oral device comprising an electrode can be used with a statin. For example, a removable oral device comprising an electrode can be used with an atorvastatin (Lipitor). A removable oral device comprising an electrode can be used with a fluvastatin (Lescol). A removable oral device comprising an electrode can be used with a rosuvastatin (Crestor). A removable oral device comprising an electrode can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device comprising an electrode.

[00298] In certain examples, a removable oral device comprising an electrode can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device comprising an electrode can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device comprising an electrode.

[00299] In certain examples, a removable oral device comprising an electrode can be used with a resin (bile-acid binding drugs). For example, a removable oral device comprising an electrode can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device comprising an electrode can be used with colestipol (Colestid®). A removable oral device comprising an electrode can be used with colesevelam HCl (WelChol®). If desired, two or more of resins can be used in combination with removable oral device comprising an electrode.

[00300] In some examples, a removable oral device comprising an electrode can be used with lipid lowering therapies. For example, a removable oral device comprising an electrode can be used with gemfibrozil (Lopid®). A removable oral device comprising an electrode can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device comprising an electrode can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device comprising an electrode.

[00301] In some examples, a removable oral device comprising an electrode can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device comprising an electrode can provide both short term and long term treatment. In some examples, a removable oral device comprising an electrode can be used with Abatacept (Orencia). A removable oral device comprising an electrode can be used with Adalimumab (Humira). A removable oral device comprising an electrode can be used with Adalimumab -atto (Amjevita), a biosimilar to Humira. A removable oral device comprising an electrode can be used with Anakinra (Kineret). A removable oral device comprising an electrode can be used with Certolizumab pegol (Cimzia). A removable oral device comprising an electrode can be used with Etanercept (Enbrel). A removable oral device comprising an electrode can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device comprising an electrode can be used with Golimumab (Simponi, Simponi Aria). A removable oral device comprising an electrode can be used with Infliximab (Remicade). A removable oral device comprising an electrode can be used with Infliximab -dyyb (Inflectra), a biosimilar to Remicade. A removable oral device comprising an electrode can be used with Rituximab (Rituxan). A removable oral device comprising an electrode can be used with Tocilizumab (Actemra). A removable oral device comprising an electrode can be used with Tofacitinib (Xeljanz). A removable oral device comprising an electrode can be used with Natalizumab (Tysabri). A removable oral device comprising an electrode can be used with Secukinumab (Cosentyx). A removable oral device comprising an electrode can be used with Ustekinumab (Stelara). A removable oral device comprising an electrode can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device comprising an electrode. In addition, two or more of the biological agents can be used in combination with a removable oral device comprising an electrode.

[00302] Combinations Comprising Removable Oral Devices without Supporting

Wires

[00303] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device. For example, the removable oral device may comprise a palatal element coupled to a clasping element, in which the palatal element is configured to contact a roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. In some instances, the clasping element does not include any supporting wires or other structures. In other examples, the palatal element may not include any clasping element whatsoever. Such removable oral devices without supporting wires can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device without supporting wires can be used in combination with one or more medical devices or implants. For example, a removable oral device without supporting wires can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with removable oral device without supporting wires.

[00304] In other configurations, a removable oral device without supporting wires can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device without supporting wires in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device without supporting wires.

[00305] In some configurations, the removable oral device without supporting wires can be used with other medical devices. For example, removable oral device without supporting wires can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device without supporting wires can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device without supporting wires can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device without supporting wires can be used with a gastric emptying system such as the Aspire assist system. A removable oral device without supporting wires can be used with a CPAP device. A removable oral device without supporting wires can be used with a knee implant. A removable oral device without supporting wires can be used with a hip implant. A removable oral device without supporting wires can be used with an ankle implant. A removable oral device without supporting wires can be used with a coronary, venous or arterial stent. A removable oral device without supporting wires can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device without supporting wires.

[00306] In other configurations, a removable oral device without supporting wires can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device without supporting wires can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device without supporting wires can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device without supporting wires can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device without supporting wires.

[00307] In other configurations, a removable oral device without supporting wires can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device without supporting wires is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device without supporting wires can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device without supporting wires can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device without supporting wires can be used with a naltrexone hydrochloride and bupropion hydrochloride extended- release tablet such as the drug commercially marketed as Contrave. A removable oral device without supporting wires can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide-1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device without supporting wires can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device without supporting wires can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device without supporting wires can be used with a lorcaserin HCl such as the drug commercially marketed as Belviq. A removable oral device without supporting wires can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device without supporting wires can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device without supporting wires can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device without supporting wires can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device without supporting wires can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device without supporting wires can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device without supporting wires can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device without supporting wires can be used with any two or more of the weight loss drugs listed herein.

[00308] In some examples, a removable oral device without supporting wires can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device without supporting wires is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device without supporting wires can be used with short acting insulin (Humulin and novolin). A removable oral device without supporting wires can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device without supporting wires can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device without supporting wires can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device without supporting wires can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device without supporting wires can be used with a somatostatin. A removable oral device without supporting wires can be used with a diazoxide. A removable oral device without supporting wires can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device without supporting wires can be used with a dopamine agonist such as bromocriptine. A removable oral device without supporting wires can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00309] In some instances, a removable oral device without supporting wires can be used with glucagon like peptides. For example, a removable oral device without supporting wires can be used with albiglutide (Tanzeum). A removable oral device without supporting wires can be used with dulaglutide (Trulicity). A removable oral device without supporting wires can be used with exenetide (Byetta). A removable oral device without supporting wires can be used with exenatide extended release (Bydureon). A removable oral device without supporting wires can be used with liraglutide (Victoza). A removable oral device without supporting wires can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide- metformin (Prandimet).

[00310] In certain examples, a removable oral device without supporting wires can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device without supporting wires can be used with dapagliflozin (Farxiga). A removable oral device without supporting wires can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device without supporting wires can be used with carnagliflozin (Invokana). A removable oral device without supporting wires can be used with canagliflozin-metformin (Invokamet). A removable oral device without supporting wires can be used with empagliflozin (Jardiance). A removable oral device without supporting wires can be used with empagliflozin- linagliptin (Glyxambi).

[00311] In other examples, a removable oral device without supporting wires can be used with a sulfonylurea. For example, a removable oral device without supporting wires can be used with glimepiride (Amaryl). A removable oral device without supporting wires can be used with glimepride-pioglitazone (Duotact). A removable oral device without supporting wires can be used with glimepiride-rosiglitazone (Avendary). A removable oral device without supporting wires can be used with gliclazide, glipizide (Glucotrol). A removable oral device without supporting wires can be used with glipizide-metformin (Metaglip). A removable oral device without supporting wires can be used with glyburide (Diabets, glynase, Micronase). A removable oral device without supporting wires can be used with chloropropamide (Diabinese). A removable oral device without supporting wires can be used with tolazamide (Tolinase). A removable oral device without supporting wires can be used with tolbutamide (Orinase, tol-tab).

[00312] In some instances, a removable oral device without supporting wires can be used with a thiazolidinedione. For example, a removable oral device without supporting wires can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device without supporting wires can be used with rosiglitazone-metformin (Amaryl M). A removable oral device without supporting wires can be used with pioglitazone (Actos). A removable oral device without supporting wires can be used with pioglitazone-alogliptin (Oseni), A removable oral device without supporting wires can be used with pilglitazone- glimepride (Duetact). A removable oral device without supporting wires can be used with pioglitazone-metformin (Actoplus met, Actoplus met xr). A removable oral device without supporting wires can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device without supporting wires can be used with a glucagon. If desired, a removable oral device without supporting wires can be used with any two, three or more of the diabetes drugs listed herein.

[00313] In some instances, a removable oral device without supporting wires can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device without supporting wires is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device without supporting wires with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00314] In certain examples, a removable oral device without supporting wires can be used with diuretic. For example, a removable oral device without supporting wires can be used with chlorthalidone (Hygroton). A removable oral device without supporting wires can be used with chlorothiazide (Diruil). A removable oral device without supporting wires can be used with furosemide (Lasix). A removable oral device without supporting wires can be used with hydrochlorothiazide (Esidrix). A removable oral device without supporting wires can be used with indapamide (Lozol). A removable oral device without supporting wires can be used with metolazone (Mykrox).

[00315] In certain instances, a removable oral device without supporting wires can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device without supporting wires can be used with combination diuretics. For example, A removable oral device without supporting wires can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device without supporting wires can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device without supporting wires can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00316] In some instances, a removable oral device without supporting wires can be used with a beta blocker. For example, A removable oral device without supporting wires can be used with acebutolol (Sectral). A removable oral device without supporting wires can be used with atenolol (Tenormin). A removable oral device without supporting wires can be used with betaxolol (Kerlone). A removable oral device without supporting wires can be used with bisoprolol fumarate (Zebeta). A removable oral device without supporting wires can be used with cartelol hydrochloride (Cartrol). A removable oral device without supporting wires can be used with metoprolol tartrate (Lopressor). A removable oral device without supporting wires can be used with metoprolol succinate (Toprol-XL). A removable oral device without supporting wires can be used with nadolol (Corgard). A removable oral device without supporting wires can be used with penbutolol sulfate (Levatol). A removable oral device without supporting wires can be used with pindolol (Visken). A removable oral device without supporting wires can be used with propanolol hydrochloride (Inderal). A removable oral device without supporting wires can be used with solotolol hydrochloride (Betapace). A removable oral device without supporting wires can be used with timolol maleate (Blocadren). A removable oral device without supporting wires can be used with, nebivolol (Bystoliv). A removable oral device without supporting wires can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00317] In some examples, a removable oral device without supporting wires can be used with an acetylcholinesterase inhibitor. For example, a removable oral device without supporting wires can be used with benaxepril hydrochloride (Lotensin). A removable oral device without supporting wires can be used with captopril (Capoten). A removable oral device without supporting wires can be used with enalpril maleate (Vasotec). A removable oral device without supporting wires can be used with fosinopril sodium (Monopril) A removable oral device without supporting wires can be used with lisonopril (Prinivel, Zestril). A removable oral device without supporting wires can be used with moexipril (Univasc). A removable oral device without supporting wires can be used with perindopril (Aceon). A removable oral device without supporting wires can be used with quinapril hydrochloride (Accupril). A removable oral device without supporting wires can be used with ramipril (Altace). A removable oral device without supporting wires can be used with trandolapril (Mavik).

[00318] In certain examples, a removable oral device without supporting wires can be used with an angiotensin II receptor blocker. For example, a removable oral device without supporting wires can be used with candesartan (Atacand). A removable oral device without supporting wires can be used with eprosartan mesylate (Teveten). A removable oral device without supporting wires can be used with irbesartan (Avapro). A removable oral device without supporting wires can be used with losartan potassium (Cozaar). A removable oral device without supporting wires can be used with telmisartan (Micardis). A removable oral device without supporting wires can be used with valsartan (Diovan).

[00319] In certain embodiments, a removable oral device without supporting wires can be used with a calcium channel blocker. For example, a removable oral device without supporting wires can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device without supporting wires can be used with bepridil (Vasocor). A removable oral device without supporting wires can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device without supporting wires can be used with felodipine (Plendil). A removable oral device without supporting wires can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device without supporting wires can be used with nicardipine (Cardene SR). A removable oral device without supporting wires can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device without supporting wires can be used with nisoldipine (Sular). A removable oral device without supporting wires can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00320] In certain embodiments, a removable oral device without supporting wires can be used with an alpha blocker. For example, a removable oral device without supporting wires can be used with doxazosin mesylate (Cardura). A removable oral device without supporting wires can be used with prazosin hydrochloride (Minipress). A removable oral device without supporting wires can be used with terazosin hydrochloride (Hytrin).

[00321] In certain embodiments, a removable oral device without supporting wires can be used with an alpha-2-receptor agonist. For example, a removable oral device without supporting wires can be used with methyldopa.

[00322] In certain embodiments, a removable oral device without supporting wires can be used with combined alpha and beta blockers. For example, a removable oral device without supporting wires can be used with carvedilol (Coreg). A removable oral device without supporting wires can be used with labetalol hydrochloride (Normodyne, Trandate).

[00323] In certain embodiments, a removable oral device without supporting wires can be used with a central agonist. For example, a removable oral device without supporting wires can be used with alpha methyldopa (Aldomet). A removable oral device without supporting wires can be used with clonidine hydrochloride (Catapres). A removable oral device without supporting wires can be used with guanabenz acetate (Wytensin). A removable oral device without supporting wires can be used with guanfacine hydrochloride (Tenex).

[00324] In certain embodiments, a removable oral device without supporting wires can be used with a peripheral adrenergic inhibitor. . For example, a removable oral device without supporting wires can be used with guanadrel (Hylorel). A removable oral device without supporting wires can be used with guanethidine monosulfate (Ismelin). A removable oral device without supporting wires can be used with reserpine (Serpasil).

[00325] In certain embodiments, a removable oral device without supporting wires can be used with a blood vessel dilator (vasodilator). For example, a removable oral device without supporting wires can be used with hydralazine hydrocholoride (Apresoline). A removable oral device without supporting wires can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device without supporting wires.

[00326] In some examples, a removable oral device without supporting wires can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device without supporting wires is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device without supporting wires with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00327] In certain examples, a removable oral device without supporting wires can be used with a statin. For example, a removable oral device without supporting wires can be used with an atorvastatin (Lipitor). A removable oral device without supporting wires can be used with a fluvastatin (Lescol). A removable oral device without supporting wires can be used with a rosuvastatin (Crestor). A removable oral device without supporting wires can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device without supporting wires.

[00328] In certain examples, a removable oral device without supporting wires can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device without supporting wires can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device without supporting wires.

[00329] In certain examples, a removable oral device without supporting wires can be used with a resin (bile-acid binding drugs). For example, a removable oral device without supporting wires can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device without supporting wires can be used with colestipol (Colestid®). A removable oral device without supporting wires can be used with colesevelam HC1 (WelChol®). If desired, two or more of resins can be used in combination with removable oral device without supporting wires.

[00330] In some examples, a removable oral device without supporting wires can be used with lipid lowering therapies. For example, a removable oral device without supporting wires can be used with gemfibrozil (Lopid®). A removable oral device without supporting wires can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device without supporting wires can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device without supporting wires.

[00331] In some examples, a removable oral device without supporting wires can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device without supporting wires can provide both short term and long term treatment. In some examples, a removable oral device without supporting wires can be used with Abatacept (Orencia). A removable oral device without supporting wires can be used with Adalimumab (Humira). A removable oral device without supporting wires can be used with Adalimumab -atto (Amjevita), a biosimilar to Humira. A removable oral device without supporting wires can be used with Anakinra (Kineret). A removable oral device without supporting wires can be used with Certolizumab pegol (Cimzia). A removable oral device without supporting wires can be used with Etanercept (Enbrel). A removable oral device without supporting wires can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device without supporting wires can be used with Golimumab (Simponi, Simponi Aria). A removable oral device without supporting wires can be used with Infliximab (Remicade). A removable oral device without supporting wires can be used with Infliximab-dyyb (Inflectra), a biosimilar to Remicade. A removable oral device without supporting wires can be used with Rituximab (Rituxan). A removable oral device without supporting wires can be used with Tocilizumab (Actemra). A removable oral device without supporting wires can be used with Tofacitinib (Xeljanz). A removable oral device without supporting wires can be used with Natalizumab (Tysabri). A removable oral device without supporting wires can be used with Secukinumab (Cosentyx). A removable oral device without supporting wires can be used with Ustekinumab (Stelara). A removable oral device without supporting wires can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device without supporting wires. In addition, two or more of the biological agents can be used in combination with a removable oral device without supporting wires.

[00332] Combinations Comprising Removable Oral Devices with Smaller Wires

[00333] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device. For example, the removable oral device may comprise a palatal element coupled to a clasping element, in which the palatal element is configured to contact a roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. The clasping element comprises a continuous wire structure terminating in the body of the palatal element. The continuous wire structure has a smaller outer wire diameter at termini of the wire structure within the clasping element than an outer wire diameter within the palatal element. Such removable oral devices with wires can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with wires can be used in combination with one or more medical devices or implants. For example, a removable oral device with wires can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with a removable oral device with wires.

[00334] In other configurations, a removable oral device with wires can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with wires in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device with wires.

[00335] In some configurations, the removable oral device with wires can be used with other medical devices. For example, removable oral device with wires can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device with wires can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device with wires can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device with wires can be used with a gastric emptying system such as the Aspire assist system. A removable oral device with wires can be used with a CPAP device. A removable oral device with wires can be used with a knee implant. A removable oral device with wires can be used with a hip implant. A removable oral device with wires can be used with an ankle implant. A removable oral device with wires can be used with a coronary, venous or arterial stent. A removable oral device with wires can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device with wires.

[00336] In other configurations, a removable oral device with wires can be used pre- operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device with wires can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device with wires can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device with wires can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device with wires.

[00337] In other configurations, a removable oral device with wires can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device with wires is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device with wires can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device with wires can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device with wires can be used with a naltrexone hydrochloride and bupropion hydrochloride extended-release tablet such as the drug commercially marketed as Contrave. A removable oral device with wires can be used with a liraglutide [rDNA origin] injection (or with another glucagon -like peptide- 1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device with wires can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device with wires can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device with wires can be used with a lorcaserin HC1 such as the drug commercially marketed as Belviq. A removable oral device with wires can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device with wires can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device with wires can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device with wires can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device with wires can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device with wires can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device with wires can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device with wires can be used with any two or more of the weight loss drugs listed herein.

[00338] In some examples, a removable oral device with wires can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with wires is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device with wires can be used with short acting insulin (Humulin and novolin). A removable oral device with wires can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device with wires can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device with wires can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device with wires can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device with wires can be used with a somatostatin. A removable oral device with wires can be used with a diazoxide. A removable oral device with wires can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device with wires can be used with a dopamine agonist such as bromocriptine. A removable oral device with wires can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00339] In some instances, a removable oral device with wires can be used with glucagon like peptides. For example, a removable oral device with wires can be used with albiglutide (Tanzeum). A removable oral device with wires can be used with dulaglutide (Trulicity). A removable oral device with wires can be used with exenetide (Byetta). A removable oral device with wires can be used with exenatide extended release (Bydureon). A removable oral device with wires can be used with liraglutide (Victoza). A removable oral device with wires can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide- metformin (Prandimet).

[00340] In certain examples, a removable oral device with wires can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device with wires can be used with dapagliflozin (Farxiga). A removable oral device with wires can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device with wires can be used with carnagliflozin (Invokana). A removable oral device with wires can be used with canagliflozin- metformin (Invokamet). A removable oral device with wires can be used with empagliflozin (Jardiance). A removable oral device with wires can be used with empagliflozin-linagliptin (Glyxambi).

[00341] In other examples, a removable oral device with wires can be used with a sulfonylurea. For example, a removable oral device with wires can be used with glimepiride (Amaryl). A removable oral device with wires can be used with glimepride-pioglitazone (Duotact). A removable oral device with wires can be used with glimepiride-rosiglitazone (Avendary). A removable oral device with wires can be used with gliclazide, glipizide (Glucotrol). A removable oral device with wires can be used with glipizide-metformin (Metaglip). A removable oral device with wires can be used with glyburide (Diabets, glynase, Micronase). A removable oral device with wires can be used with chloropropamide (Diabinese). A removable oral device with wires can be used with tolazamide (Tolinase). A removable oral device with wires can be used with tolbutamide (Orinase, tol-tab).

[00342] In some instances, a removable oral device with wires can be used with a thiazolidinedione. For example, a removable oral device with wires can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device with wires can be used with rosiglitazone-metformin (Amaryl M). A removable oral device with wires can be used with pioglitazone (Actos). A removable oral device with wires can be used with pioglitazone-alogliptin (Oseni), A removable oral device with wires can be used with pilglitazone-glimepride (Duetact). A removable oral device with wires can be used with pioglitazone-metformin (Actoplus met, Actoplus met xr). A removable oral device with wires can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device with wires can be used with a glucagon. If desired, a removable oral device with wires can be used with any two, three or more of the diabetes drugs listed herein.

[00343] In some instances, a removable oral device with wire can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device with wires is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device with wires with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00344] In certain examples, a removable oral device with wires can be used with diuretic. For example, a removable oral device with wires can be used with chlorthalidone (Hygroton). A removable oral device with wires can be used with chlorothiazide (Diruil). A removable oral device with wires can be used with furosemide (Lasix). A removable oral device with wires can be used with hydrochlorothiazide (Esidrix). A removable oral device with wires can be used with indapamide (Lozol). A removable oral device with wires can be used with metolazone (Mykrox).

[00345] In certain instances, a removable oral device with wires can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device with wires can be used with combination diuretics. For example, A removable oral device with wires can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device with wires can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device with wires can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00346] In some instances, a removable oral device with wires can be used with a beta blocker. For example, A removable oral device with wires can be used with acebutolol (Sectral). A removable oral device with wires can be used with atenolol (Tenormin). A removable oral device with wires can be used with betaxolol (Kerlone). A removable oral device with wires can be used with bisoprolol fumarate (Zebeta). A removable oral device with wires can be used with cartelol hydrochloride (Cartrol). A removable oral device with wires can be used with metoprolol tartrate (Lopressor). A removable oral device with wires can be used with metoprolol succinate (Toprol-XL). A removable oral device with wires can be used with nadolol (Corgard). A removable oral device with wires can be used with penbutolol sulfate (Levatol). A removable oral device with wires can be used with pindolol (Visken). A removable oral device with wires can be used with propanolol hydrochloride (Inderal). A removable oral device with wires can be used with solotolol hydrochloride (Betapace). A removable oral device with wires can be used with timolol maleate (Blocadren). A removable oral device with wires can be used with, nebivolol (Bystoliv). A removable oral device with wires can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00347] In some examples, a removable oral device with wires can be used with an acetylcholinesterase inhibitor. For example, a removable oral device with wires can be used with benaxepril hydrochloride (Lotensin). A removable oral device with wires can be used with captopril (Capoten). A removable oral device with wires can be used with enalpril maleate (Vasotec). A removable oral device with wires can be used with fosinopril sodium (Monopril) A removable oral device with wires can be used with lisonopril (Prinivel, Zestril). A removable oral device with wires can be used with moexipril (Univasc). A removable oral device with wires can be used with perindopril (Aceon). A removable oral device with wires can be used with quinapril hydrochloride (Accupril). A removable oral device with wires can be used with ramipril (Altace). A removable oral device with wires can be used with trandolapril (Mavik).

[00348] In certain examples, a removable oral device with wires can be used with an angiotensin II receptor blocker. For example, a removable oral device with wires can be used with candesartan (Atacand). A removable oral device with wires can be used with eprosartan mesylate (Teveten). A removable oral device with wires can be used with irbesartan (Avapro). A removable oral device with wires can be used with losartan potassium (Cozaar). A removable oral device with wires can be used with telmisartan (Micardis). A removable oral device with wires can be used with valsartan (Diovan).

[00349] In certain embodiments, a removable oral device with wires can be used with a calcium channel blocker. For example, a removable oral device with wires can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device with wires can be used with bepridil (Vasocor). A removable oral device with wires can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device with wires can be used with felodipine (Plendil). A removable oral device with wires can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device with wires can be used with nicardipine (Cardene SR). A removable oral device with wires can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device with wires can be used with nisoldipine (Sular). A removable oral device with wires can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00350] In certain embodiments, a removable oral device with wires can be used with an alpha blocker. For example, a removable oral device with wires can be used with doxazosin mesylate (Cardura). A removable oral device with wires can be used with prazosin hydrochloride (Minipress). A removable oral device with wires can be used with terazosin hydrochloride (Hytrin).

[00351] In certain embodiments, a removable oral device with wires can be used with an alpha-2-receptor agonist. For example, a removable oral device with wires can be used with methyldopa.

[00352] In certain embodiments, a removable oral device with wires can be used with combined alpha and beta blockers. For example, a removable oral device with wires can be used with carvedilol (Coreg). A removable oral device with wires can be used with labetalol hydrochloride (Normodyne, Trandate).

[00353] In certain embodiments, a removable oral device with wires can be used with a central agonist. For example, a removable oral device with wires can be used with alpha methyldopa (Aldomet). A removable oral device with wires can be used with clonidine hydrochloride (Catapres). A removable oral device with wires can be used with guanabenz acetate (Wytensin). A removable oral device with wires can be used with guanfacine hydrochloride (Tenex).

[00354] In certain embodiments, a removable oral device with wires can be used with a peripheral adrenergic inhibitor. . For example, a removable oral device with wires can be used with guanadrel (Hylorel). A removable oral device with wires can be used with guanethidine monosulfate (Ismelin). A removable oral device with wires can be used with reserpine (Serpasil).

[00355] In certain embodiments, a removable oral device with wires can be used with a blood vessel dilator (vasodilator). For example, a removable oral device with wires can be used with hydralazine hydrocholoride (Apresoline). A removable oral device with wires can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device with wires.

[00356] In some examples, a removable oral device with wires can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device with wires is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device with wires with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00357] In certain examples, a removable oral device with wires can be used with a statin. For example, a removable oral device with wires can be used with an atorvastatin (Lipitor). A removable oral device with wires can be used with a fluvastatin (Lescol). A removable oral device with wires can be used with a rosuvastatin (Crestor). A removable oral device with wires can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device with wires.

[00358] In certain examples, a removable oral device with wires can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device with wires can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device with wires.

[00359] In certain examples, a removable oral device with wires can be used with a resin (bile-acid binding drugs). For example, a removable oral device with wires can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device with wires can be used with colestipol (Colestid®). A removable oral device with wires can be used with colesevelam HCl (WelChol®). If desired, two or more of resins can be used in combination with removable oral device with wires.

[00360] In some examples, a removable oral device with wires can be used with lipid lowering therapies. For example, a removable oral device with wires can be used with gemfibrozil (Lopid®). A removable oral device with wires can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device with wires can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device with wires.

[00361] In some examples, a removable oral device with wires can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device with wires can provide both short term and long term treatment. In some examples, a removable oral device with wires can be used with Abatacept (Orencia). A removable oral device with wires can be used with Adalimumab (Humira). A removable oral device with wires can be used with Adalimumab-atto (Amjevita), a biosimilar to Humira. A removable oral device with wires can be used with Anakinra (Kineret). A removable oral device with wires can be used with Certolizumab pegol (Cimzia). A removable oral device with wires can be used with Etanercept (Enbrel). A removable oral device with wires can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device with wires can be used with Golimumab (Simponi, Simponi Aria). A removable oral device with wires can be used with Infliximab (Remicade). A removable oral device with wires can be used with Infliximab -dyyb (Inflectra), a biosimilar to Remicade. A removable oral device with wires can be used with Rituximab (Rituxan). A removable oral device with wires can be used with Tocilizumab (Actemra). A removable oral device with wires can be used with Tofacitinib (Xeljanz). A removable oral device with wires can be used with Natalizumab (Tysabri). A removable oral device with wires can be used with Secukinumab (Cosentyx). A removable oral device with wires can be used with Ustekinumab (Stelara). A removable oral device with wires can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device with wires. In addition, two or more of the biological agents can be used in combination with a removable oral device with wires.

[00362] Combinations Comprising Removable Oral Devices with a Palatal Element of Varying or Adjustable Thickness

[00363] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device comprising a palatal element of varying thickness or an adjustable thickness as described in SCIINTAK-700100. For example, the palatal element can be configured to contact a roof of a user's mouth at a palatal surface and comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. The palatal element has a lower thickness at a front section adjacent to inner surfaces of the anterior teeth to reduce lisping compared to a thickness at an apex section of the palatal element. In other examples, the thickness of the palatal element can be altered by introducing air or a liquid into an internal bladder or other similar internal device. The clasping element is configured to assist in removal of the removable oral device from the mouth. Such removable oral devices with the specified palatal element can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with the specified palatal element can be used in combination with one or more medical devices or implants. For example, a removable oral device with the specified palatal element can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with a removable oral device with the specified palatal element.

[00364] In other configurations, a removable oral device with the specified palatal element can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with the specified palatal element in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with a removable oral device with the specified palatal element.

[00365] In some configurations, the removable oral device with the specified palatal element can be used with other medical devices. For example, removable oral device with the specified palatal element can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device with the specified palatal element can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device with the specified palatal element can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device with the specified palatal element can be used with a gastric emptying system such as the Aspire assist system. A removable oral device with the specified palatal element can be used with a CPAP device. A removable oral device with the specified palatal element can be used with a knee implant. A removable oral device with the specified palatal element can be used with a hip implant. A removable oral device with the specified palatal element can be used with an ankle implant. A removable oral device with the specified palatal element can be used with a coronary, venous or arterial stent. A removable oral device with the specified palatal element can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device with the specified palatal element. [00366] In other configurations, a removable oral device with the specified palatal element can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device with the specified palatal element can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device with the specified palatal element can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device with the specified palatal element can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device with the specified palatal element.

[00367] In other configurations, a removable oral device with the specified palatal element can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device with the specified palatal element is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device with the specified palatal element can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device with the specified palatal element can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device with the specified palatal element can be used with a naltrexone hydrochloride and bupropion hydrochloride extended-release tablet such as the drug commercially marketed as Contrave. A removable oral device with the specified palatal element can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide- 1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device with the specified palatal element can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device with the specified palatal element can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device with the specified palatal element can be used with a lorcaserin HCl such as the drug commercially marketed as Belviq. A removable oral device with the specified palatal element can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device with the specified palatal element can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device with the specified palatal element can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device with the specified palatal element can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device with the specified palatal element can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device with the specified palatal element can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device with the specified palatal element can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device with the specified palatal element can be used with any two or more of the weight loss drugs listed herein.

[00368] In some examples, a removable oral device with the specified palatal element can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with the specified palatal element is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device with the specified palatal element can be used with short acting insulin (Humulin and novolin). A removable oral device with the specified palatal element can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device with the specified palatal element can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device with the specified palatal element can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device with the specified palatal element can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device with the specified palatal element can be used with a somatostatin. A removable oral device with the specified palatal element can be used with a diazoxide. A removable oral device with the specified palatal element can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device with the specified palatal element can be used with a dopamine agonist such as bromocriptine. A removable oral device with the specified palatal element can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00369] In some instances, a removable oral device with the specified palatal element can be used with glucagon like peptides. For example, a removable oral device with the specified palatal element can be used with albiglutide (Tanzeum). A removable oral device with the specified palatal element can be used with dulaglutide (Trulicity). A removable oral device with the specified palatal element can be used with exenetide (Byetta). A removable oral device with the specified palatal element can be used with exenatide extended release (Bydureon). A removable oral device with the specified palatal element can be used with liraglutide (Victoza). A removable oral device with the specified palatal element can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet). [00370] In certain examples, a removable oral device with the specified palatal element can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device with the specified palatal element can be used with dapagliflozin (Farxiga). A removable oral device with the specified palatal element can be used with dapagliflozin- metformin (Xigduo xr). A removable oral device with the specified palatal element can be used with camaglifiozin (Invokana). A removable oral device with the specified palatal element can be used with canagliflozin-metformin (Invokamet). A removable oral device with the specified palatal element can be used with empaglifiozin (Jardiance). A removable oral device with the specified palatal element can be used with empaglifiozin-linagliptin (Glyxambi).

[00371] In other examples, a removable oral device with the specified palatal element can be used with a sulfonylurea. For example, a removable oral device with the specified palatal element can be used with glimepiride (Amaryl). A removable oral device with the specified palatal element can be used with glimepride-pioglitazone (Duotact). A removable oral device with the specified palatal element can be used with glimepiride-rosiglitazone (Avendary). A removable oral device with the specified palatal element can be used with gliclazide, glipizide (Glucotrol). A removable oral device with the specified palatal element can be used with glipizide-metformin (Metaglip). A removable oral device with the specified palatal element can be used with glyburide (Diabets, glynase, Micronase). A removable oral device with the specified palatal element can be used with chloropropamide (Diabinese). A removable oral device with the specified palatal element can be used with tolazamide (Tolinase). A removable oral device with the specified palatal element can be used with tolbutamide (Orinase, tol-tab).

[00372] In some instances, a removable oral device with the specified palatal element can be used with a thiazolidinedione. For example, a removable oral device with the specified palatal element can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device with the specified palatal element can be used with rosiglitazone - metformin (Amaryl M). A removable oral device with the specified palatal element can be used with pioglitazone (Actos). A removable oral device with the specified palatal element can be used with pioglitazone-alogliptin (Oseni), A removable oral device with the specified palatal element can be used with pilglitazone-glimepride (Duetact). A removable oral device with the specified palatal element can be used with pioglitazone-metformin (Actoplus met, Actoplus met xr). A removable oral device with the specified palatal element can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device with the specified palatal element can be used with a glucagon. If desired, a removable oral device with the specified palatal element can be used with any two, three or more of the diabetes drugs listed herein. [00373] In some instances, a removable oral device with the specified palatal element can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device with the specified palatal element is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device with the specified palatal element with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00374] In certain examples, a removable oral device with the specified palatal element can be used with diuretic. For example, a removable oral device with the specified palatal element can be used with chlorthalidone (Hygroton). A removable oral device with the specified palatal element can be used with chlorothiazide (Diruil). A removable oral device with the specified palatal element can be used with furosemide (Lasix). A removable oral device with the specified palatal element can be used with hydrochlorothiazide (Esidrix). A removable oral device with the specified palatal element can be used with indapamide (Lozol). A removable oral device with the specified palatal element can be used with metolazone (Mykrox).

[00375] In certain instances, a removable oral device with the specified palatal element can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device with the specified palatal element can be used with combination diuretics. For example, A removable oral device with the specified palatal element can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device with the specified palatal element can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device with the specified palatal element can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00376] In some instances, a removable oral device with the specified palatal element can be used with a beta blocker. For example, A removable oral device with the specified palatal element can be used with acebutolol (Sectral). A removable oral device with the specified palatal element can be used with atenolol (Tenormin). A removable oral device with the specified palatal element can be used with betaxolol (Kerlone). A removable oral device with the specified palatal element can be used with bisoprolol fumarate (Zebeta). A removable oral device with the specified palatal element can be used with cartelol hydrochloride (Cartrol). A removable oral device with the specified palatal element can be used with metoprolol tartrate (Lopressor). A removable oral device with the specified palatal element can be used with metoprolol succinate (Toprol-XL). A removable oral device with the specified palatal element can be used with nadolol (Corgard). A removable oral device with the specified palatal element can be used with penbutolol sulfate (Levatol). A removable oral device with the specified palatal element can be used with pindolol (Visken). A removable oral device with the specified palatal element can be used with propanolol hydrochloride (Inderal). A removable oral device with the specified palatal element can be used with solotolol hydrochloride (Betapace). A removable oral device with the specified palatal element can be used with timolol maleate (Blocadren). A removable oral device with the specified palatal element can be used with, nebivolol (Bystoliv). A removable oral device with the specified palatal element can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00377] In some examples, a removable oral device with the specified palatal element can be used with an acetylcholinesterase inhibitor. For example, a removable oral device with the specified palatal element can be used with benaxepril hydrochloride (Lotensin). A removable oral device with the specified palatal element can be used with captopril (Capoten). A removable oral device with the specified palatal element can be used with enalpril maleate (Vasotec). A removable oral device with the specified palatal element can be used with fosinopril sodium (Monopril) A removable oral device with the specified palatal element can be used with lisonopril (Prinivel, Zestril). A removable oral device with the specified palatal element can be used with moexipril (Univasc). A removable oral device with the specified palatal element can be used with perindopril (Aceon). A removable oral device with the specified palatal element can be used with quinapril hydrochloride (Accupril). A removable oral device with the specified palatal element can be used with ramipril (Altace). A removable oral device with the specified palatal element can be used with trandolapril (Mavik).

[00378] In certain examples, a removable oral device with the specified palatal element can be used with an angiotensin II receptor blocker. For example, a removable oral device with the specified palatal element can be used with candesartan (Atacand). A removable oral device with the specified palatal element can be used with eprosartan mesylate (Teveten). A removable oral device with the specified palatal element can be used with irbesartan (Avapro). A removable oral device with the specified palatal element can be used with losartan potassium (Cozaar). A removable oral device with the specified palatal element can be used with telmisartan (Micardis). A removable oral device with the specified palatal element can be used with valsartan (Diovan).

[00379] In certain embodiments, a removable oral device with the specified palatal element can be used with a calcium channel blocker. For example, a removable oral device with the specified palatal element can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device with the specified palatal element can be used with bepridil (Vasocor). A removable oral device with the specified palatal element can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device with the specified palatal element can be used with felodipine (Plendil). A removable oral device with the specified palatal element can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device with the specified palatal element can be used with nicardipine (Cardene SR). A removable oral device with the specified palatal element can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device with the specified palatal element can be used with nisoldipine (Sular). A removable oral device with the specified palatal element can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00380] In certain embodiments, a removable oral device with the specified palatal element can be used with an alpha blocker. For example, a removable oral device with the specified palatal element can be used with doxazosin mesylate (Cardura). A removable oral device with the specified palatal element can be used with prazosin hydrochloride (Minipress). A removable oral device with the specified palatal element can be used with terazosin hydrochloride (Hytrin).

[00381] In certain embodiments, a removable oral device with the specified palatal element can be used with an alpha-2-receptor agonist. For example, a removable oral device with the specified palatal element can be used with methyldopa.

[00382] In certain embodiments, a removable oral device with the specified palatal element can be used with combined alpha and beta blockers. For example, a removable oral device with the specified palatal element can be used with carvedilol (Coreg). A removable oral device with the specified palatal element can be used with labetalol hydrochloride (Normodyne, Trandate).

[00383] In certain embodiments, a removable oral device with the specified palatal element can be used with a central agonist. For example, a removable oral device with the specified palatal element can be used with alpha methyldopa (Aldomet). A removable oral device with the specified palatal element can be used with clonidine hydrochloride (Catapres). A removable oral device with the specified palatal element can be used with guanabenz acetate (Wytensin). A removable oral device with the specified palatal element can be used with guanfacine hydrochloride (Tenex).

[00384] In certain embodiments, a removable oral device with the specified palatal element can be used with a peripheral adrenergic inhibitor. . For example, a removable oral device with the specified palatal element can be used with guanadrel (Hylorel). A removable oral device with the specified palatal element can be used with guanethidine monosulfate (Ismelin). A removable oral device with the specified palatal element can be used with reserpine (Serpasil).

[00385] In certain embodiments, a removable oral device with the specified palatal element can be used with a blood vessel dilator (vasodilator). For example, a removable oral device with the specified palatal element can be used with hydralazine hydrocholoride (Apresoline). A removable oral device with the specified palatal element can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device with the specified palatal element.

[00386] In some examples, a removable oral device specified palatal element can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device specified palatal element is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device specified palatal element with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00387] In certain examples, a removable oral device with the specified palatal element can be used with a statin. For example, a removable oral device with the specified palatal element can be used with an atorvastatin (Lipitor). A removable oral device with the specified palatal element can be used with a fluvastatin (Lescol). A removable oral device with the specified palatal element can be used with a rosuvastatin (Crestor). A removable oral device with the specified palatal element can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device with the specified palatal element.

[00388] In certain examples, a removable oral device with the specified palatal element can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device with the specified palatal element can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device with the specified palatal element. [00389] In certain examples, a removable oral device with the specified palatal element can be used with a resin (bile-acid binding drugs). For example, a removable oral device with the specified palatal element can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device with the specified palatal element can be used with colestipol (Colestid®). A removable oral device with the specified palatal element can be used with colesevelam HC1 (WelChol®). If desired, two or more of resins can be used in combination with removable oral device with the specified palatal element.

[00390] In some examples, a removable oral device with the specified palatal element can be used with lipid lowering therapies. For example, a removable oral device with the specified palatal element can be used with gemfibrozil (Lopid®). A removable oral device with the specified palatal element can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device with the specified palatal element can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device with the specified palatal element.

[00391] In some examples, a removable oral device with the specified palatal element can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device with the specified palatal element can provide both short term and long term treatment. In some examples, a removable oral device with the specified palatal element can be used with Abatacept (Orencia). A removable oral device with the specified palatal element can be used with Adalimumab (Humira). A removable oral device with the specified palatal element can be used with Adalimumab -atto (Amjevita), a biosimilar to Humira. A removable oral device with the specified palatal element can be used with Anakinra (Kineret). A removable oral device with the specified palatal element can be used with Certolizumab pegol (Cimzia). A removable oral device with the specified palatal element can be used with Etanercept (Enbrel). A removable oral device with the specified palatal element can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device with the specified palatal element can be used with Golimumab (Simponi, Simponi Aria). A removable oral device with the specified palatal element can be used with Infliximab (Remicade). A removable oral device with the specified palatal element can be used with Infliximab -dyyb (Inflectra), a biosimilar to Remicade. A removable oral device with the specified palatal element can be used with Rituximab (Rituxan). A removable oral device with the specified palatal element can be used with Tocilizumab (Actemra). A removable oral device with the specified palatal element can be used with Tofacitinib (Xeljanz). A removable oral device with the specified palatal element can be used with Natalizumab (Tysabri). A removable oral device with the specified palatal element can be used with Secukinumab (Cosentyx). A removable oral device with the specified palatal element can be used with Ustekinumab (Stelara). A removable oral device with the specified palatal element can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device with the specified palatal element. In addition, two or more of the biological agents can be used in combination with a removable oral device with the specified palatal element.

[00392] Combinations Comprising Removable Oral Devices with a Thermally

Expandable Material

[00393] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device comprising a thermally expandable material. For example, the palatal element may comprise a thermally expandable material configured to increase its volume with increasing temperature to decrease the overall oral volume to a second oral volume less than the first oral volume. The clasping element is configured to assist in removal of the removable oral device from the mouth. Such removable oral devices with the specified thermally expandable material can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with the specified thermally expandable material can be used in combination with one or more medical devices or implants. For example, a removable oral device with the specified thermally expandable material can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with a removable oral device with the specified thermally expandable material.

[00394] In other configurations, a removable oral device with the specified thermally expandable material can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with the specified thermally expandable material in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with a removable oral device with the specified thermally expandable material.

[00395] In some configurations, the removable oral device with the specified thermally expandable material can be used with other medical devices. For example, removable oral device with the specified thermally expandable material can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device with the specified thermally expandable material can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device with the specified thermally expandable material can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device with the specified thermally expandable material can be used with a gastric emptying system such as the Aspire assist system. A removable oral device with the specified thermally expandable material can be used with a CPAP device. A removable oral device with the specified thermally expandable material can be used with a knee implant. A removable oral device with the specified thermally expandable material can be used with a hip implant. A removable oral device with the specified thermally expandable material can be used with an ankle implant. A removable oral device with the specified thermally expandable material can be used with a coronary, venous or arterial stent. A removable oral device with the specified thermally expandable material can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device with the specified thermally expandable material.

[00396] In other configurations, a removable oral device with the specified thermally expandable material can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device with the specified thermally expandable material can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device with the specified thermally expandable material can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device with the specified thermally expandable material can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device with the specified thermally expandable material.

[00397] In other configurations, a removable oral device with the specified thermally expandable material can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device with the specified thermally expandable material is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device with the specified thermally expandable material can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device with the specified thermally expandable material can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device with the specified thermally expandable material can be used with a naltrexone hydrochloride and bupropion hydrochloride extended-release tablet such as the drug commercially marketed as Contrave. A removable oral device with the specified thermally expandable material can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide-1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device with the specified thermally expandable material can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device with the specified thermally expandable material can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device with the specified thermally expandable material can be used with a lorcaserin HC1 such as the drug commercially marketed at Belviq. A removable oral device with the specified thermally expandable material can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device with the specified thermally expandable material can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device with the specified thermally expandable material can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device with the specified thermally expandable material can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device with the specified thermally expandable material can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device with the specified thermally expandable material can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device with the specified thermally expandable material can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device with the specified thermally expandable material can be used with any two or more of the weight loss drugs listed herein.

[00398] In some examples, a removable oral device with the specified thermally expandable material can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with the specified thermally expandable material is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device with the specified thermally expandable material can be used with short acting insulin (Humulin and novolin). A removable oral device with the specified thermally expandable material can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device with the specified thermally expandable material can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device with the specified thermally expandable material can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device with the specified thermally expandable material can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device with the specified thermally expandable material can be used with a somatostatin. A removable oral device with the specified thermally expandable material can be used with a diazoxide. A removable oral device with the specified thermally expandable material can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device with the specified thermally expandable material can be used with a dopamine agonist such as bromocriptine. A removable oral device with the specified thermally expandable material can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00399] In some instances, a removable oral device with the specified thermally expandable material can be used with glucagon like peptides. For example, a removable oral device with the specified thermally expandable material can be used with albiglutide (Tanzeum). A removable oral device with the specified thermally expandable material can be used with dulaglutide (Trulicity). A removable oral device with the specified thermally expandable material can be used with exenetide (Byetta). A removable oral device with the specified thermally expandable material can be used with exenatide extended release (Bydureon). A removable oral device with the specified thermally expandable material can be used with liraglutide (Victoza). A removable oral device with the specified thermally expandable material can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00400] In certain examples, a removable oral device with the specified thermally expandable material can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device with the specified thermally expandable material can be used with dapagliflozin (Farxiga). A removable oral device with the specified thermally expandable material can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device with the specified thermally expandable material can be used with carnagliflozin (Invokana). A removable oral device with the specified thermally expandable material can be used with canagliflozin-metformin (Invokamet). A removable oral device with the specified thermally expandable material can be used with empagliflozin (Jardiance). A removable oral device with the specified thermally expandable material can be used with empaglifiozin-linagliptin (Glyxambi).

[00401] In other examples, a removable oral device with the specified thermally expandable material can be used with a sulfonylurea. For example, a removable oral device with the specified thermally expandable material can be used with glimepiride (Amaryl). A removable oral device with the specified thermally expandable material can be used with glimepride-pioglitazone (Duotact). A removable oral device with the specified thermally expandable material can be used with glimepiride-rosiglitazone (Avendary). A removable oral device with the specified thermally expandable material can be used with gliclazide, glipizide (Glucotrol). A removable oral device with the specified thermally expandable material can be used with glipizide-metformin (Metaglip). A removable oral device with the specified thermally expandable material can be used with glyburide (Diabets, glynase, Micronase). A removable oral device with the specified thermally expandable material can be used with chloropropamide (Diabinese). A removable oral device with the specified thermally expandable material can be used with tolazamide (Tolinase). A removable oral device with the specified thermally expandable material can be used with tolbutamide (Orinase, tol-tab).

[00402] In some instances, a removable oral device with the specified thermally expandable material can be used with a thiazolidinedione. For example, a removable oral device with the specified thermally expandable material can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device with the specified thermally expandable material can be used with rosiglitazone-metformin (Amaryl M). A removable oral device with the specified thermally expandable material can be used with pioglitazone (Actos). A removable oral device with the specified thermally expandable material can be used with pioglitazone-alogliptin (Oseni), A removable oral device with the specified thermally expandable material can be used with pilglitazone-glimepride (Duetact). A removable oral device with the specified thermally expandable material can be used with pioglitazone- metformin (Actoplus met, Actoplus met xr). A removable oral device with the specified thermally expandable material can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device with the specified thermally expandable material can be used with a glucagon. If desired, a removable oral device with the specified thermally expandable material can be used with any two, three or more of the diabetes drugs listed herein.

[00403] In some instances, a removable oral device with the specified thermally expandable material can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device with the specified thermally expandable material is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device with the specified thermally expandable material with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00404] In certain examples, a removable oral device with the specified thermally expandable material can be used with diuretic. For example, a removable oral device with the specified thermally expandable material can be used with chlorthalidone (Hygroton). A removable oral device with the specified thermally expandable material can be used with chlorothiazide (Diruil). A removable oral device with the specified thermally expandable material can be used with furosemide (Lasix). A removable oral device with the specified thermally expandable material can be used with hydrochlorothiazide (Esidrix). A removable oral device with the specified thermally expandable material can be used with indapamide (Lozol). A removable oral device with the specified thermally expandable material can be used with metolazone (Mykrox).

[00405] In certain instances, a removable oral device with the specified thermally expandable material can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device with the specified thermally expandable material can be used with combination diuretics. For example, A removable oral device with the specified thermally expandable material can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device with the specified thermally expandable material can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device with the specified thermally expandable material can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00406] In some instances, a removable oral device with the specified thermally expandable material can be used with a beta blocker. For example, A removable oral device with the specified thermally expandable material can be used with acebutolol (Sectral). A removable oral device with the specified thermally expandable material can be used with atenolol (Tenormin). A removable oral device with the specified thermally expandable material can be used with betaxolol (Kerlone). A removable oral device with the specified thermally expandable material can be used with bisoprolol fumarate (Zebeta). A removable oral device with the specified thermally expandable material can be used with cartelol hydrochloride (Cartrol). A removable oral device with the specified thermally expandable material can be used with metoprolol tartrate (Lopressor). A removable oral device with the specified thermally expandable material can be used with metoprolol succinate (Toprol-XL). A removable oral device with the specified thermally expandable material can be used with nadolol (Corgard). A removable oral device with the specified thermally expandable material can be used with penbutolol sulfate (Levatol). A removable oral device with the specified thermally expandable material can be used with pindolol (Visken). A removable oral device with the specified thermally expandable material can be used with propanolol hydrochloride (Inderal). A removable oral device with the specified thermally expandable material can be used with solotolol hydrochloride (Betapace). A removable oral device with the specified thermally expandable material can be used with timolol maleate (Blocadren). A removable oral device with the specified thermally expandable material can be used with, nebivolol (Bystoliv). A removable oral device with the specified thermally expandable material can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00407] In some examples, a removable oral device with the specified thermally expandable material can be used with an acetylcholinesterase inhibitor. For example, a removable oral device with the specified thermally expandable material can be used with benaxepril hydrochloride (Lotensin). A removable oral device with the specified thermally expandable material can be used with captopril (Capoten). A removable oral device with the specified thermally expandable material can be used with enalpril maleate (Vasotec). A removable oral device with the specified thermally expandable material can be used with fosinopril sodium (Monopril) A removable oral device with the specified thermally expandable material can be used with lisonopril (Prinivel, Zestril). A removable oral device with the specified thermally expandable material can be used with moexipril (Univasc). A removable oral device with the specified thermally expandable material can be used with perindopril (Aceon). A removable oral device with the specified thermally expandable material can be used with quinapril hydrochloride (Accupril). A removable oral device with the specified thermally expandable material can be used with ramipril (Altace). A removable oral device with the specified thermally expandable material can be used with trandolapril (Mavik). [00408] In certain examples, a removable oral device with the specified thermally expandable material can be used with an angiotensin II receptor blocker. For example, a removable oral device with the specified thermally expandable material can be used with candesartan (Atacand). A removable oral device with the specified thermally expandable material can be used with eprosartan mesylate (Teveten). A removable oral device with the specified thermally expandable material can be used with irbesartan (Avapro). A removable oral device with the specified thermally expandable material can be used with losartan potassium (Cozaar). A removable oral device with the specified thermally expandable material can be used with telmisartan (Micardis). A removable oral device with the specified thermally expandable material can be used with valsartan (Diovan).

[00409] In certain embodiments, a removable oral device with the specified thermally expandable material can be used with a calcium channel blocker. For example, a removable oral device with the specified thermally expandable material can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device with the specified thermally expandable material can be used with bepridil (Vasocor). A removable oral device with the specified thermally expandable material can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device with the specified thermally expandable material can be used with felodipine (Plendil). A removable oral device with the specified thermally expandable material can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device with the specified thermally expandable material can be used with nicardipine (Cardene SR). A removable oral device with the specified thermally expandable material can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device with the specified thermally expandable material can be used with nisoldipine (Sular). A removable oral device with the specified thermally expandable material can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00410] In certain embodiments, a removable oral device with the specified thermally expandable material can be used with an alpha blocker. For example, a removable oral device with the specified thermally expandable material can be used with doxazosin mesylate (Cardura). A removable oral device with the specified thermally expandable material can be used with prazosin hydrochloride (Minipress). A removable oral device with the specified thermally expandable material can be used with terazosin hydrochloride (Hytrin).

[00411] In certain embodiments, a removable oral device with the specified thermally expandable material can be used with an alpha-2-receptor agonist. For example, a removable oral device with the specified thermally expandable material can be used with methyldopa. [00412] In certain embodiments, a removable oral device with the specified thermally expandable material can be used with combined alpha and beta blockers. For example, a removable oral device with the specified thermally expandable material can be used with carvedilol (Coreg). A removable oral device with the specified thermally expandable material can be used with labetalol hydrochloride (Normodyne, Trandate).

[00413] In certain embodiments, a removable oral device with the specified thermally expandable material can be used with a central agonist. For example, a removable oral device with the specified thermally expandable material can be used with alpha methyldopa (Aldomet). A removable oral device with the specified thermally expandable material can be used with clonidine hydrochloride (Catapres). A removable oral device with the specified thermally expandable material can be used with guanabenz acetate (Wytensin). A removable oral device with the specified thermally expandable material can be used with guanfacine hydrochloride (Tenex).

[00414] In certain embodiments, a removable oral device with the specified thermally expandable material can be used with a peripheral adrenergic inhibitor. . For example, a removable oral device with the specified thermally expandable material can be used with guanadrel (Hylorel). A removable oral device with the specified thermally expandable material can be used with guanethidine monosulfate (Ismelin). A removable oral device with the specified thermally expandable material can be used with reserpine (Serpasil).

[00415] In certain embodiments, a removable oral device with the specified thermally expandable material can be used with a blood vessel dilator (vasodilator). For example, a removable oral device with the specified thermally expandable material can be used with hydralazine hydrocholoride (Apresoline). A removable oral device with the specified thermally expandable material can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device with the specified thermally expandable material.

[00416] In some examples, a removable oral device with the specified thermally expandable material can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device with the specified thermally expandable material is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device with the specified thermally expandable material with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00417] In certain examples, a removable oral device with the specified thermally expandable material can be used with a statin. For example, a removable oral device with the specified thermally expandable material can be used with an atorvastatin (Lipitor). A removable oral device with the specified thermally expandable material can be used with a fluvastatin (Lescol). A removable oral device with the specified thermally expandable material can be used with a rosuvastatin (Crestor). A removable oral device with the specified thermally expandable material can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device with the specified thermally expandable material.

[00418] In certain examples, a removable oral device with the specified thermally expandable material can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device with the specified thermally expandable material can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device with the specified thermally expandable material.

[00419] In certain examples, a removable oral device with the specified thermally expandable material can be used with a resin (bile-acid binding drugs). For example, a removable oral device with the specified thermally expandable material can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device with the specified thermally expandable material can be used with colestipol (Colestid®). A removable oral device with the specified thermally expandable material can be used with colesevelam HC1 (WelChol®). If desired, two or more of resins can be used in combination with removable oral device with the specified thermally expandable material.

[00420] In some examples, a removable oral device with the specified thermally expandable material can be used with lipid lowering therapies. For example, a removable oral device with the specified thermally expandable material can be used with gemfibrozil (Lopid®). A removable oral device with the specified thermally expandable material can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device with the specified thermally expandable material can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device with the specified thermally expandable material. [00421] In some examples, a removable oral device with the specified thermally expandable material can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device with the specified thermally expandable material can provide both short term and long term treatment. In some examples, a removable oral device with the specified thermally expandable material can be used with Abatacept (Orencia). A removable oral device with the specified thermally expandable material can be used with Adalimumab (Humira). A removable oral device with the specified thermally expandable material can be used with Adalimumab -atto (Amjevita), a biosimilar to Humira. A removable oral device with the specified thermally expandable material can be used with Anakinra (Kineret). A removable oral device with the specified thermally expandable material can be used with Certolizumab pegol (Cimzia). A removable oral device with the specified thermally expandable material can be used with Etanercept (Enbrel). A removable oral device with the specified thermally expandable material can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device with the specified thermally expandable material can be used with Golimumab (Simponi, Simponi Aria). A removable oral device with the specified thermally expandable material can be used with Infliximab (Remicade). A removable oral device with the specified thermally expandable material can be used with Infliximab -dyyb (Inflectra), a biosimilar to Remicade. A removable oral device with the specified thermally expandable material can be used with Rituximab (Rituxan). A removable oral device with the specified thermally expandable material can be used with Tocilizumab (Actemra). A removable oral device with the specified thermally expandable material can be used with Tofacitinib (Xeljanz). A removable oral device with the specified thermally expandable material can be used with Natalizumab (Tysabri). A removable oral device with the specified thermally expandable material can be used with Secukinumab (Cosentyx). A removable oral device with the specified thermally expandable material can be used with Ustekinumab (Stelara). A removable oral device with the specified thermally expandable material can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device with the specified thermally expandable material. In addition, two or more of the biological agents can be used in combination with a removable oral device with the specified thermally expandable material.

[00422] Combinations Comprising Removable Oral Devices with Multiple Palatal

Elements [00423] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device comprising two or more palatal elements that can be coupled to each other. For example, a first palatal element can be configured to contact a roof of a user's mouth at a palatal surface. The first palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. The first palatal element can be configured to reversibly couple to a second palatal element to decrease the overall oral volume of the mouth to a second oral volume less than the first oral volume. The clasping element is configured to assist in removal of the removable oral device from the mouth. Such removable oral devices with the specified palatal elements can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with the specified palatal elements can be used in combination with one or more medical devices or implants. For example, a removable oral device with the specified palatal elements can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with a removable oral device with the specified palatal elements.

[00424] In other configurations, a removable oral device with the specified palatal elements can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with the specified palatal elements in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with a removable oral device with the specified palatal elements.

[00425] In some configurations, the removable oral device with the specified palatal elements can be used with other medical devices. For example, removable oral device with the specified palatal elements can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device with the specified palatal elements can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device with the specified palatal elements can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device with the specified palatal elements can be used with a gastric emptying system such as the Aspire assist system. A removable oral device with the specified palatal elements can be used with a CPAP device. A removable oral device with the specified palatal elements can be used with a knee implant. A removable oral device with the specified palatal elements can be used with a hip implant. A removable oral device with the specified palatal elements can be used with an ankle implant. A removable oral device with the specified palatal elements can be used with a coronary, venous or arterial stent. A removable oral device with the specified palatal elements can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device with the specified palatal elements.

[00426] In other configurations, a removable oral device with the specified palatal elements can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device with the specified palatal elements can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device with the specified palatal elements can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device with the specified palatal elements can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device with the specified palatal elements.

[00427] In other configurations, a removable oral device with the specified palatal elements can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device with the specified palatal elements is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device with the specified palatal elements can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device with the specified palatal elements can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device with the specified palatal elements can be used with a naltrexone hydrochloride and bupropion hydrochloride extended-release tablet such as the drug commercially marketed as Contrave. A removable oral device with the specified palatal elements can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide- 1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device with the specified palatal elements can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device with the specified palatal elements can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device with the specified palatal elements can be used with a lorcaserin HC1 such as the drug commercially marketed at Belviq. A removable oral device with the specified palatal elements can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device with the specified palatal elements can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device with the specified palatal elements can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device with the specified palatal elements can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device with the specified palatal elements can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device with the specified palatal elements can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device with the specified palatal elements can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device with the specified palatal elements can be used with any two or more of the weight loss drugs listed herein.

[00428] In some examples, a removable oral device with the specified palatal elements can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with the specified palatal elements is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device with the specified palatal elements can be used with short acting insulin (Humulin and novolin). A removable oral device with the specified palatal elements can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device with the specified palatal elements can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device with the specified palatal elements can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device with the specified palatal elements can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device with the specified palatal elements can be used with a somatostatin. A removable oral device with the specified palatal elements can be used with a diazoxide. A removable oral device with the specified palatal elements can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device with the specified palatal elements can be used with a dopamine agonist such as bromocriptine. A removable oral device with the specified palatal elements can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00429] In some instances, a removable oral device with the specified palatal elements can be used with glucagon like peptides. For example, a removable oral device with the specified palatal elements can be used with albiglutide (Tanzeum). A removable oral device with the specified palatal elements can be used with dulaglutide (Trulicity). A removable oral device with the specified palatal elements can be used with exenetide (Byetta). A removable oral device with the specified palatal elements can be used with exenatide extended release (Bydureon). A removable oral device with the specified palatal elements can be used with liraglutide (Victoza). A removable oral device with the specified palatal elements can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00430] In certain examples, a removable oral device with the specified palatal elements can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device with the specified palatal elements can be used with dapagliflozin (Farxiga). A removable oral device with the specified palatal elements can be used with dapagliflozin- metformin (Xigduo xr). A removable oral device with the specified palatal elements can be used with carnaglifiozin (Invokana). A removable oral device with the specified palatal elements can be used with canagliflozin-metformin (Invokamet). A removable oral device with the specified palatal elements can be used with empaglifiozin (Jardiance). A removable oral device with the specified palatal elements can be used with empagliflozin-linagliptin (Glyxambi).

[00431] In other examples, a removable oral device with the specified palatal elements can be used with a sulfonylurea. For example, a removable oral device with the specified palatal elements can be used with glimepiride (Amaryl). A removable oral device with the specified palatal elements can be used with glimepride-pioglitazone (Duotact). A removable oral device with the specified palatal elements can be used with glimepiride-rosiglitazone (Avendary). A removable oral device with the specified palatal elements can be used with gliclazide, glipizide (Glucotrol). A removable oral device with the specified palatal elements can be used with glipizide-metformin (Metaglip). A removable oral device with the specified palatal elements can be used with glyburide (Diabets, glynase, Micronase). A removable oral device with the specified palatal elements can be used with chloropropamide (Diabinese). A removable oral device with the specified palatal elements can be used with tolazamide (Tolinase). A removable oral device with the specified palatal elements can be used with tolbutamide (Orinase, tol-tab).

[00432] In some instances, a removable oral device with the specified palatal elements can be used with a thiazolidinedione. For example, a removable oral device with the specified palatal elements can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device with the specified palatal elements can be used with rosiglitazone - metformin (Amaryl M). A removable oral device with the specified palatal elements can be used with pioglitazone (Actos). A removable oral device with the specified palatal elements can be used with pioglitazone-alogliptin (Oseni), A removable oral device with the specified palatal elements can be used with pilglitazone-glimepride (Duetact). A removable oral device with the specified palatal elements can be used with pioglitazone-metformin (Actoplus met, Actoplus met xr). A removable oral device with the specified palatal elements can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device with the specified palatal elements can be used with a glucagon. If desired, a removable oral device with the specified palatal elements can be used with any two, three or more of the diabetes drugs listed herein.

[00433] In some instances, a removable oral device with the specified palatal elements can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device with the specified palatal elements is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device with the specified palatal elements with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00434] In certain examples, a removable oral device with the specified palatal elements can be used with diuretic. For example, a removable oral device with the specified palatal elements can be used with chlorthalidone (Hygroton). A removable oral device with the specified palatal elements can be used with chlorothiazide (Diruil). A removable oral device with the specified palatal elements can be used with furosemide (Lasix). A removable oral device with the specified palatal elements can be used with hydrochlorothiazide (Esidrix). A removable oral device with the specified palatal elements can be used with indapamide (Lozol). A removable oral device with the specified palatal elements can be used with metolazone (Mykrox). [00435] In certain instances, a removable oral device with the specified palatal elements can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device with the specified palatal elements can be used with combination diuretics. For example, A removable oral device with the specified palatal elements can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device with the specified palatal elements can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device with the specified palatal elements can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00436] In some instances, a removable oral device with the specified palatal elements can be used with a beta blocker. For example, A removable oral device with the specified palatal elements can be used with acebutolol (Sectral). A removable oral device with the specified palatal elements can be used with atenolol (Tenormin). A removable oral device with the specified palatal elements can be used with betaxolol (Kerlone). A removable oral device with the specified palatal elements can be used with bisoprolol fumarate (Zebeta). A removable oral device with the specified palatal elements can be used with cartelol hydrochloride (Cartrol). A removable oral device with the specified palatal elements can be used with metoprolol tartrate (Lopressor). A removable oral device with the specified palatal elements can be used with metoprolol succinate (Toprol-XL). A removable oral device with the specified palatal elements can be used with nadolol (Corgard). A removable oral device with the specified palatal elements can be used with penbutolol sulfate (Levatol). A removable oral device with the specified palatal elements can be used with pindolol (Visken). A removable oral device with the specified palatal elements can be used with propanolol hydrochloride (Inderal). A removable oral device with the specified palatal elements can be used with solotolol hydrochloride (Betapace). A removable oral device with the specified palatal elements can be used with timolol maleate (Blocadren). A removable oral device with the specified palatal elements can be used with, nebivolol (Bystoliv). A removable oral device with the specified palatal elements can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00437] In some examples, a removable oral device with the specified palatal elements can be used with an acetylcholinesterase inhibitor. For example, a removable oral device with the specified palatal elements can be used with benaxepril hydrochloride (Lotensin). A removable oral device with the specified palatal elements can be used with captopril (Capoten). A removable oral device with the specified palatal elements can be used with enalpril maleate (Vasotec). A removable oral device with the specified palatal elements can be used with fosinopril sodium (Monopril) A removable oral device with the specified palatal elements can be used with lisonopril (Prinivel, Zestril). A removable oral device with the specified palatal elements can be used with moexipril (Univasc). A removable oral device with the specified palatal elements can be used with perindopril (Aceon). A removable oral device with the specified palatal elements can be used with quinapril hydrochloride (Accupril). A removable oral device with the specified palatal elements can be used with ramipril (Altace). A removable oral device with the specified palatal elements can be used with trandolapril (Mavik).

[00438] In certain examples, a removable oral device with the specified palatal elements can be used with an angiotensin II receptor blocker. For example, a removable oral device with the specified palatal elements can be used with candesartan (Atacand). A removable oral device with the specified palatal elements can be used with eprosartan mesylate (Teveten). A removable oral device with the specified palatal elements can be used with irbesartan (Avapro). A removable oral device with the specified palatal elements can be used with losartan potassium (Cozaar). A removable oral device with the specified palatal elements can be used with telmisartan (Micardis). A removable oral device with the specified palatal elements can be used with valsartan (Diovan).

[00439] In certain embodiments, a removable oral device with the specified palatal elements can be used with a calcium channel blocker. For example, a removable oral device with the specified palatal elements can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device with the specified palatal elements can be used with bepridil (Vasocor). A removable oral device with the specified palatal elements can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device with the specified palatal elements can be used with felodipine (Plendil). A removable oral device with the specified palatal elements can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device with the specified palatal elements can be used with nicardipine (Cardene SR). A removable oral device with the specified palatal elements can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device with the specified palatal elements can be used with nisoldipine (Sular). A removable oral device with the specified palatal elements can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00440] In certain embodiments, a removable oral device with the specified palatal elements can be used with an alpha blocker. For example, a removable oral device with the specified palatal elements can be used with doxazosin mesylate (Cardura). A removable oral device with the specified palatal elements can be used with prazosin hydrochloride (Minipress). A removable oral device with the specified palatal elements can be used with terazosin hydrochloride (Hytrin). [00441] In certain embodiments, a removable oral device with the specified palatal elements can be used with an alpha-2-receptor agonist. For example, a removable oral device with the specified palatal elements can be used with methyldopa.

[00442] In certain embodiments, a removable oral device with the specified palatal elements can be used with combined alpha and beta blockers. For example, a removable oral device with the specified palatal elements can be used with carvedilol (Coreg). A removable oral device with the specified palatal elements can be used with labetalol hydrochloride (Normodyne, Trandate).

[00443] In certain embodiments, a removable oral device with the specified palatal elements can be used with a central agonist. For example, a removable oral device with the specified palatal elements can be used with alpha methyldopa (Aldomet). A removable oral device with the specified palatal elements can be used with clonidine hydrochloride (Catapres). A removable oral device with the specified palatal elements can be used with guanabenz acetate (Wytensin). A removable oral device with the specified palatal elements can be used with guanfacine hydrochloride (Tenex).

[00444] In certain embodiments, a removable oral device with the specified palatal elements can be used with a peripheral adrenergic inhibitor. . For example, a removable oral device with the specified palatal elements can be used with guanadrel (Hylorel). A removable oral device with the specified palatal elements can be used with guanethidine monosulfate (Ismelin). A removable oral device with the specified palatal elements can be used with reserpine (Serpasil).

[00445] In certain embodiments, a removable oral device with the specified palatal elements can be used with a blood vessel dilator (vasodilator). For example, a removable oral device with the specified palatal elements can be used with hydralazine hydrocholoride (Apresoline). A removable oral device with the specified palatal elements can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device with the specified palatal elements.

[00446] In some examples, a removable oral device with the specified palatal elements can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device with the specified palatal elements is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device with the specified palatal elements with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00447] In certain examples, a removable oral device with the specified palatal elements can be used with a statin. For example, a removable oral device with the specified palatal elements can be used with an atorvastatin (Lipitor). A removable oral device with the specified palatal elements can be used with a fluvastatin (Lescol). A removable oral device with the specified palatal elements can be used with a rosuvastatin (Crestor). A removable oral device with the specified palatal elements can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device with the specified palatal elements.

[00448] In certain examples, a removable oral device with the specified palatal elements can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device with the specified palatal elements can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device with the specified palatal elements.

[00449] In certain examples, a removable oral device with the specified palatal elements can be used with a resin (bile-acid binding drugs). For example, a removable oral device with the specified palatal elements can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device with the specified palatal elements can be used with colestipol (Colestid®). A removable oral device with the specified palatal elements can be used with colesevelam HCl (WelChol®). If desired, two or more of resins can be used in combination with removable oral device with the specified palatal elements.

[00450] In some examples, a removable oral device with the specified palatal elements can be used with lipid lowering therapies. For example, a removable oral device with the specified palatal elements can be used with gemfibrozil (Lopid®). A removable oral device with the specified palatal elements can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device with the specified palatal elements can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device with the specified palatal elements.

[00451] In some examples, a removable oral device with the specified palatal elements can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device with the specified palatal elements can provide both short term and long term treatment. In some examples, a removable oral device with the specified palatal elements can be used with Abatacept (Orencia). A removable oral device with the specified palatal elements can be used with Adalimumab (Humira). A removable oral device with the specified palatal elements can be used with Adalimumab -atto (Amjevita), a biosimilar to Humira. A removable oral device with the specified palatal elements can be used with Anakinra (Kineret). A removable oral device with the specified palatal elements can be used with Certolizumab pegol (Cimzia). A removable oral device with the specified palatal elements can be used with Etanercept (Enbrel). A removable oral device with the specified palatal elements can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device with the specified palatal elements can be used with Golimumab (Simponi, Simponi Aria). A removable oral device with the specified palatal elements can be used with Infliximab (Remicade). A removable oral device with the specified palatal elements can be used with Infliximab-dyyb (Inflectra), a biosimilar to Remicade. A removable oral device with the specified palatal elements can be used with Rituximab (Rituxan). A removable oral device with the specified palatal elements can be used with Tocilizumab (Actemra). A removable oral device with the specified palatal elements can be used with Tofacitinib (Xeljanz). A removable oral device with the specified palatal elements can be used with Natalizumab (Tysabri). A removable oral device with the specified palatal elements can be used with Secukinumab (Cosentyx). A removable oral device with the specified palatal elements can be used with Ustekinumab (Stelara). A removable oral device with the specified palatal elements can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device with the specified palatal elements. In addition, two or more of the biological agents can be used in combination with a removable oral device with the specified palatal elements.

[00452] Combinations Comprising Removable Oral Devices with a Chewing Sensor

[00453] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device comprising a chewing sensor. For example, a chewing sensor, which is typically present in a palatal element but can be present in a clasping element, can be configured to provide sensory feedback to the user between swallowing of food in the user's mouth, e.g., it may vibrate, provide an audible cue, etc. Such removable oral devices with the chewing sensor can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device with the chewing sensor can be used in combination with one or more medical devices or implants. For example, a removable oral device with the chewing sensor can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with a removable oral device with the chewing sensor.

[00454] In other configurations, a removable oral device with the chewing sensor can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device with the chewing sensor in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with a removable oral device with the chewing sensor.

[00455] In some configurations, the removable oral device with the chewing sensor can be used with other medical devices. For example, removable oral device with the chewing sensor can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device with the chewing sensor can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device with the chewing sensor can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device with the chewing sensor can be used with a gastric emptying system such as the Aspire assist system. A removable oral device with the chewing sensor can be used with a CPAP device. A removable oral device with the chewing sensor can be used with a knee implant. A removable oral device with the chewing sensor can be used with a hip implant. A removable oral device with the chewing sensor can be used with an ankle implant. A removable oral device with the chewing sensor can be used with a coronary, venous or arterial stent. A removable oral device with the chewing sensor can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device with the chewing sensor. [00456] In other configurations, a removable oral device with the chewing sensor can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device with the chewing sensor can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device with the chewing sensor can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device with the chewing sensor can be used with open heart and percutaneous surgery.

If desired, two or more of surgical methods can be used in combination with removable oral device with the chewing sensor.

[00457] In other configurations, a removable oral device with the chewing sensor can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device with the chewing sensor is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device with the chewing sensor can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device with the chewing sensor can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device with the chewing sensor can be used with a naltrexone hydrochloride and bupropion hydrochloride extended- release tablet such as the drug commercially marketed as Contrave. A removable oral device with the chewing sensor can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide-1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device with the chewing sensor can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device with the chewing sensor can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device with the chewing sensor can be used with a lorcaserin HCl such as the drug commercially marketed at Belviq. A removable oral device with the chewing sensor can be used with an orlistat such as those commercially marketed as Alli and Xenical. A removable oral device with the chewing sensor can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device with the chewing sensor can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device with the chewing sensor can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device with the chewing sensor can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device with the chewing sensor can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device with the chewing sensor can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device with the chewing sensor can be used with any two or more of the weight loss drugs listed herein.

[00458] In some examples, a removable oral device with the chewing sensor can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device with the chewing sensor is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device with the chewing sensor can be used with short acting insulin (Humulin and novolin). A removable oral device with the chewing sensor can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device with the chewing sensor can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device with the chewing sensor can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device with the chewing sensor can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device with the chewing sensor can be used with a somatostatin. A removable oral device with the chewing sensor can be used with a diazoxide. A removable oral device with the chewing sensor can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device with the chewing sensor can be used with a dopamine agonist such as bromocriptine. A removable oral device with the chewing sensor can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00459] In some instances, a removable oral device with the chewing sensor can be used with glucagon like peptides. For example, a removable oral device with the chewing sensor can be used with albiglutide (Tanzeum). A removable oral device with the chewing sensor can be used with dulaglutide (Trulicity). A removable oral device with the chewing sensor can be used with exenetide (Byetta). A removable oral device with the chewing sensor can be used with exenatide extended release (Bydureon). A removable oral device with the chewing sensor can be used with liraglutide (Victoza). A removable oral device with the chewing sensor can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00460] In certain examples, a removable oral device with the chewing sensor can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device with the chewing sensor can be used with dapagliflozin (Farxiga). A removable oral device with the chewing sensor can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device with the chewing sensor can be used with carnagliflozin (Invokana). A removable oral device with the chewing sensor can be used with canagliflozin-metformin (Invokamet). A removable oral device with the chewing sensor can be used with empagliflozin (Jardiance). A removable oral device with the chewing sensor can be used with empagliflozin-linagliptin (Glyxambi).

[00461] In other examples, a removable oral device with the chewing sensor can be used with a sulfonylurea. For example, a removable oral device with the chewing sensor can be used with glimepiride (Amaryl). A removable oral device with the chewing sensor can be used with glimepride-pioglitazone (Duotact). A removable oral device with the chewing sensor can be used with glimepiride-rosiglitazone (Avendary). A removable oral device with the chewing sensor can be used with gliclazide, glipizide (Glucotrol). A removable oral device with the chewing sensor can be used with glipizide-metformin (Metaglip). A removable oral device with the chewing sensor can be used with glyburide (Diabets, glynase, Micronase). A removable oral device with the chewing sensor can be used with chloropropamide (Diabinese). A removable oral device with the chewing sensor can be used with tolazamide (Tolinase). A removable oral device with the chewing sensor can be used with tolbutamide (Orinase, tol-tab).

[00462] In some instances, a removable oral device with the chewing sensor can be used with a thiazolidinedione. For example, a removable oral device with the chewing sensor can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device with the chewing sensor can be used with rosiglitazone-metformin (Amaryl M). A removable oral device with the chewing sensor can be used with pioglitazone (Actos). A removable oral device with the chewing sensor can be used with pioglitazone-alogliptin (Oseni), A removable oral device with the chewing sensor can be used with pilglitazone-glimepride (Duetact). A removable oral device with the chewing sensor can be used with pioglitazone- metformin (Actoplus met, Actoplus met xr). A removable oral device with the chewing sensor can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device with the chewing sensor can be used with a glucagon. If desired, a removable oral device with the chewing sensor can be used with any two, three or more of the diabetes drugs listed herein.

[00463] In some instances, a removable oral device with the chewing sensor can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device with the chewing sensor is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device with the chewing sensor with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00464] In certain examples, a removable oral device with the chewing sensor can be used with diuretic. For example, a removable oral device with the chewing sensor can be used with chlorthalidone (Hygroton). A removable oral device with the chewing sensor can be used with chlorothiazide (Diruil). A removable oral device with the chewing sensor can be used with furosemide (Lasix). A removable oral device with the chewing sensor can be used with hydrochlorothiazide (Esidrix). A removable oral device with the chewing sensor can be used with indapamide (Lozol). A removable oral device with the chewing sensor can be used with metolazone (Mykrox).

[00465] In certain instances, a removable oral device with the chewing sensor can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device with the chewing sensor can be used with combination diuretics. For example, A removable oral device with the chewing sensor can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device with the chewing sensor can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device with the chewing sensor can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00466] In some instances, a removable oral device with the chewing sensor can be used with a beta blocker. For example, A removable oral device with the chewing sensor can be used with acebutolol (Sectral). A removable oral device with the chewing sensor can be used with atenolol (Tenormin). A removable oral device with the chewing sensor can be used with betaxolol (Kerlone). A removable oral device with the chewing sensor can be used with bisoprolol fumarate (Zebeta). A removable oral device with the chewing sensor can be used with cartelol hydrochloride (Cartrol). A removable oral device with the chewing sensor can be used with metoprolol tartrate (Lopressor). A removable oral device with the chewing sensor can be used with metoprolol succinate (Toprol-XL). A removable oral device with the chewing sensor can be used with nadolol (Corgard). A removable oral device with the chewing sensor can be used with penbutolol sulfate (Levatol). A removable oral device with the chewing sensor can be used with pindolol (Visken). A removable oral device with the chewing sensor can be used with propanolol hydrochloride (Inderal). A removable oral device with the chewing sensor can be used with solotolol hydrochloride (Betapace). A removable oral device with the chewing sensor can be used with timolol maleate (Blocadren). A removable oral device with the chewing sensor can be used with, nebivolol (Bystoliv). A removable oral device with the chewing sensor can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00467] In some examples, a removable oral device with the chewing sensor can be used with an acetylcholinesterase inhibitor. For example, a removable oral device with the chewing sensor can be used with benaxepril hydrochloride (Lotensin). A removable oral device with the chewing sensor can be used with captopril (Capoten). A removable oral device with the chewing sensor can be used with enalpril maleate (Vasotec). A removable oral device with the chewing sensor can be used with fosinopril sodium (Monopril) A removable oral device with the chewing sensor can be used with lisonopril (Prinivel, Zestril). A removable oral device with the chewing sensor can be used with moexipril (Univasc). A removable oral device with the chewing sensor can be used with perindopril (Aceon). A removable oral device with the chewing sensor can be used with quinapril hydrochloride (Accupril). A removable oral device with the chewing sensor can be used with ramipril (Altace). A removable oral device with the chewing sensor can be used with trandolapril (Mavik).

[00468] In certain examples, a removable oral device with the chewing sensor can be used with an angiotensin II receptor blocker. For example, a removable oral device with the chewing sensor can be used with candesartan (Atacand). A removable oral device with the chewing sensor can be used with eprosartan mesylate (Teveten). A removable oral device with the chewing sensor can be used with irbesartan (Avapro). A removable oral device with the chewing sensor can be used with losartan potassium (Cozaar). A removable oral device with the chewing sensor can be used with telmisartan (Micardis). A removable oral device with the chewing sensor can be used with valsartan (Diovan).

[00469] In certain embodiments, a removable oral device with the chewing sensor can be used with a calcium channel blocker. For example, a removable oral device with the chewing sensor can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device with the chewing sensor can be used with bepridil (Vasocor). A removable oral device with the chewing sensor can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device with the chewing sensor can be used with felodipine (Plendil). A removable oral device with the chewing sensor can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device with the chewing sensor can be used with nicardipine (Cardene SR). A removable oral device with the chewing sensor can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device with the chewing sensor can be used with nisoldipine (Sular). A removable oral device with the chewing sensor can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan). [00470] In certain embodiments, a removable oral device with the chewing sensor can be used with an alpha blocker. For example, a removable oral device with the chewing sensor can be used with doxazosin mesylate (Cardura). A removable oral device with the chewing sensor can be used with prazosin hydrochloride (Minipress). A removable oral device with the chewing sensor can be used with terazosin hydrochloride (Hytrin).

[00471] In certain embodiments, a removable oral device with the chewing sensor can be used with an alpha-2-receptor agonist. For example, a removable oral device with the chewing sensor can be used with methyldopa.

[00472] In certain embodiments, a removable oral device with the chewing sensor can be used with combined alpha and beta blockers. For example, a removable oral device with the chewing sensor can be used with carvedilol (Coreg). A removable oral device with the chewing sensor can be used with labetalol hydrochloride (Normodyne, Trandate).

[00473] In certain embodiments, a removable oral device with the chewing sensor can be used with a central agonist. For example, a removable oral device with the chewing sensor can be used with alpha methyldopa (Aldomet). A removable oral device with the chewing sensor can be used with clonidine hydrochloride (Catapres). A removable oral device with the chewing sensor can be used with guanabenz acetate (Wytensin). A removable oral device with the chewing sensor can be used with guanfacine hydrochloride (Tenex).

[00474] In certain embodiments, a removable oral device with the chewing sensor can be used with a peripheral adrenergic inhibitor. For example, a removable oral device with the chewing sensor can be used with guanadrel (Hylorel). A removable oral device with the chewing sensor can be used with guanethidine monosulfate (Ismelin). A removable oral device with the chewing sensor can be used with reserpine (Serpasil).

[00475] In certain embodiments, a removable oral device with the chewing sensor can be used with a blood vessel dilator (vasodilator). For example, a removable oral device with the chewing sensor can be used with hydralazine hydrocholoride (Apresoline). A removable oral device with the chewing sensor can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device with the chewing sensor.

[00476] In some examples, a removable oral device with the chewing sensor can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device with the chewing sensor is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device with the chewing sensor with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00477] In certain examples, a removable oral device with the chewing sensor can be used with a statin. For example, a removable oral device with the chewing sensor can be used with an atorvastatin (Lipitor). A removable oral device with the chewing sensor can be used with a fluvastatin (Lescol). A removable oral device with the chewing sensor can be used with a rosuvastatin (Crestor). A removable oral device with the chewing sensor can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device with the chewing sensor.

[00478] In certain examples, a removable oral device with the chewing sensor can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device with the chewing sensor can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device with the chewing sensor.

[00479] In certain examples, a removable oral device with the chewing sensor can be used with a resin (bile-acid binding drugs). For example, a removable oral device with the chewing sensor can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device with the chewing sensor can be used with colestipol (Colestid®). A removable oral device with the chewing sensor can be used with colesevelam HCl (WelChol®). If desired, two or more of resins can be used in combination with removable oral device with the chewing sensor.

[00480] In some examples, a removable oral device with the chewing sensor can be used with lipid lowering therapies. For example, a removable oral device with the chewing sensor can be used with gemfibrozil (Lopid®). A removable oral device with the chewing sensor can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Tri glide™). A removable oral device with the chewing sensor can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device with the chewing sensor.

[00481] In some examples, a removable oral device with the chewing sensor can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody.

In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device with the chewing sensor can provide both short term and long term treatment. In some examples, a removable oral device with the chewing sensor can be used with Abatacept (Orencia). A removable oral device with the chewing sensor can be used with Adalimumab (Humira). A removable oral device with the chewing sensor can be used with Adalimumab -atto (Amjevita), a biosimilar to Humira. A removable oral device with the chewing sensor can be used with Anakinra (Kineret). A removable oral device with the chewing sensor can be used with Certolizumab pegol (Cimzia). A removable oral device with the chewing sensor can be used with Etanercept (Enbrel). A removable oral device with the chewing sensor can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device with the chewing sensor can be used with Golimumab (Simponi, Simponi Aria). A removable oral device with the chewing sensor can be used with Infliximab (Remicade). A removable oral device with the chewing sensor can be used with Infliximab -dyyb (Inflectra), a biosimilar to Remicade. A removable oral device with the chewing sensor can be used with Rituximab (Rituxan). A removable oral device with the chewing sensor can be used with Tocilizumab (Actemra). A removable oral device with the chewing sensor can be used with Tofacitinib (Xeljanz). A removable oral device with the chewing sensor can be used with Natalizumab (Tysabri). A removable oral device with the chewing sensor can be used with Secukinumab (Cosentyx). A removable oral device with the chewing sensor can be used with Ustekinumab (Stelara). A removable oral device with the chewing sensor can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device with the chewing sensor. In addition, two or more of the biological agents can be used in combination with a removable oral device with the chewing sensor.

[00482] Kits Comprising Removable Oral Devices

[00483] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device in a kit. The kit may optionally include instructions for using the removable oral device and other material or device for an intended purpose. Such kits with a removable oral device as described herein can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the kit with a removable oral device as described herein can be used in combination with one or more medical devices or implants. For example, a kit with a removable oral device as described herein may also comprise an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with a kit with a removable oral device as described herein.

[00484] In other configurations, a kit with a removable oral device as described herein may also comprise a swallowable balloon to treat, for example, obesity or being overweight. The use of a kit with a removable oral device as described herein with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with a kit with a removable oral device as described herein.

[00485] In some configurations, the kit with a removable oral device as described herein may also comprise other medical devices. For example, a kit with a removable oral device as described herein may also comprise an endoscopic endoluminal sleeve such as Endobarrier sleeve. A kit with a removable oral device as described herein may also comprise an electrical stimulation systems such as the Maestro rechargeable system. A kit with a removable oral device as described herein may also comprise a gastric band such as Lap Band, Realize Gastric Band. A kit with a removable oral device as described herein may also comprise a gastric emptying system such as the Aspire assist system. A kit with a removable oral device as described herein may also comprise a CPAP device. A kit with a removable oral device as described herein may also comprise a knee implant. A kit with a removable oral device as described herein may also comprise a hip implant. A kit with a removable oral device as described herein may also comprise an ankle implant. A kit with a removable oral device as described herein may also comprise a coronary, venous or arterial stent. A kit with a removable oral device as described herein may also comprise angioplasty devices. If desired, two or more of medical devices can be used in combination with kit with a removable oral device as described herein.

[00486] In other configurations, a kit with a removable oral device as described herein can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A kit with a removable oral device as described herein may also comprise gastric bypass surgery. A removable oral device may also comprise sleeve gastrectomy. A kit with a removable oral device as described herein may also comprise bilio pancreatic diversion w/duodenal switch. A kit with a removable oral device as described herein may also comprise open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with kit with a removable oral device as described herein.

[00487] In other configurations, a kit with a removable oral device as described herein can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a kit with a removable oral device as described herein is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A kit with a removable oral device as described herein may also comprise a weight loss drug comprising a primary amine stimulant. A kit with a removable oral device as described herein may also comprise a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A kit with a removable oral device as described herein may also comprise a naltrexone hydrochloride and bupropion hydrochloride extended-release tablet such as the drug commercially marketed as Contrave. A kit with a removable oral device as described herein may also comprise a liraglutide [rDNA origin] injection (or with another glucagon-like peptide-1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A kit with a removable oral device as described herein may also comprise a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A kit with a removable oral device as described herein may also comprise a phentermine + topiramate such as the drug commercially marketed as Qsymia. A kit with a removable oral device as described herein may also comprise a lorcaserin HC1 such as the drug commercially marketed at Belviq. A kit with a removable oral device as described herein may also comprise an orlistat such as those commercially marketed as Alii and Xenical. A kit with a removable oral device as described herein may also comprise a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A kit with a removable oral device as described herein may also comprise a sibutramine such as the drug commercially marketed as Meridia. A kit with a removable oral device as described herein may also comprise a phendimetrazine such as the drug commercially marketed as Bontril. A kit with a removable oral device as described herein may also comprise a methamphetamine such as the one commercially marketed as Desoxyn. A kit with a removable oral device as described herein may also comprise a benzphetamine such as the drug commercially marketed as Didrex. A kit with a removable oral device as described herein may also comprise a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a kit with a removable oral device as described herein may also comprise any two or more of the weight loss drugs listed herein. [00488] In some examples, a kit with a removable oral device as described herein can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a kit with a removable oral device as described herein is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A kit with a removable oral device as described herein may also comprise short acting insulin (Humulin and novolin). A kit with a removable oral device as described herein may also comprise rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A kit with a removable oral device as described herein may also comprise intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A kit with a removable oral device as described herein may also comprise long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A kit with a removable oral device as described herein may also comprise mixtures of insulins (Novolog Mix, Humolog mix). A kit with a removable oral device as described herein may also comprise a somatostatin. A kit with a removable oral device as described herein may also comprise a diazoxide. A kit with a removable oral device as described herein may also comprise a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A kit with a removable oral device as described herein may also comprise a dopamine agonist such as bromocriptine. A kit with a removable oral device as described herein may also comprise a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00489] In some instances, a kit with a removable oral device as described herein may also comprise glucagon like peptides. For example, a kit with a removable oral device as described herein may also comprise albiglutide (Tanzeum). A kit with a removable oral device as described herein may also comprise dulaglutide (Trulicity). A kit with a removable oral device as described herein may also comprise exenetide (Byetta). A kit with a removable oral device as described herein may also comprise exenatide extended release (Bydureon). A kit with a removable oral device as described herein may also comprise liraglutide (Victoza). A kit with a removable oral device as described herein may also comprise a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00490] In certain examples, a kit with a removable oral device as described herein may also comprise a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a kit with a removable oral device as described herein may also comprise dapagliflozin (Farxiga). A kit with a removable oral device as described herein may also comprise dapagliflozin-metformin

(Xigduo xr). A kit with a removable oral device as described herein may also comprise carnagliflozin (Invokana). A kit with a removable oral device as described herein may also comprise canagliflozin-metformin (Invokamet). A kit with a removable oral device as described herein may also comprise empagliflozin (Jardiance). A kit with a removable oral device as described herein may also comprise empagliflozin-linagliptin (Glyxambi).

[00491] In other examples, a kit with a removable oral device as described herein may also comprise a sulfonylurea. For example, a kit with a removable oral device as described herein may also comprise glimepiride (Amaryl). A kit with a removable oral device as described herein may also comprise glimepride-pioglitazone (Duotact). A kit with a removable oral device as described herein may also comprise glimepiride-rosiglitazone (Avendary). A kit with a removable oral device as described herein may also comprise gliclazide, glipizide (Glucotrol). A kit with a removable oral device as described herein may also comprise glipizide-metformin (Metaglip). A kit with a removable oral device as described herein may also comprise glyburide (Diabets, glynase, Micronase). A kit with a removable oral device as described herein may also comprise chloropropamide (Diabinese). A kit with a removable oral device as described herein may also comprise tolazamide (Tolinase). A kit with a removable oral device as described herein may also comprise tolbutamide (Orinase, tol-tab).

[00492] In some instances, a kit with a removable oral device as described herein may also comprise a thiazolidinedione. For example, a kit with a removable oral device as described herein may also comprise rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A kit with a removable oral device as described herein may also comprise rosiglitazone-metformin (Amaryl M). A kit with a removable oral device as described herein may also comprise pioglitazone (Actos). A kit with a removable oral device as described herein may also comprise pioglitazone-alogliptin (Oseni), A kit with a removable oral device as described herein may also comprise pilglitazone-glimepride (Duetact). A kit with a removable oral device as described herein may also comprise pioglitazone-metformin (Actoplus met, Actoplus met xr). A kit with a removable oral device as described herein may also comprise an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A kit with a removable oral device as described herein may also comprise a glucagon. If desired, a kit with a removable oral device as described herein may also comprise any two, three or more of the diabetes drugs listed herein.

[00493] In some instances, a removable oral device as described herein can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device as described herein is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device as described herein with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00494] In certain examples, a kit with a removable oral device as described herein may also comprise diuretic. For example, a kit with a removable oral device as described herein may also comprise chlorthalidone (Hygroton). A kit with a removable oral device as described herein may also comprise chlorothiazide (Diruil). A kit with a removable oral device as described herein may also comprise furosemide (Lasix). A kit with a removable oral device as described herein may also comprise hydrochlorothiazide (Esidrix). A kit with a removable oral device as described herein may also comprise indapamide (Lozol). A kit with a removable oral device as described herein may also comprise metolazone (Mykrox).

[00495] In certain instances, a kit with a removable oral device as described herein may also comprise a loop diuretic such as, for example, bumetanide (Bumex). A kit with a removable oral device as described herein may also comprise combination diuretics. For example, A kit with a removable oral device as described herein may also comprise amiloride + hydrochlorothiazide (Moduretic). A kit with a removable oral device as described herein may also comprise spironolactone + hydrochlorothiazide (Aldactazide). A kit with a removable oral device as described herein may also comprise triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00496] In some instances, a kit with a removable oral device as described herein may also comprise a beta blocker. For example, A kit with a removable oral device as described herein may also comprise acebutolol (Sectral). A kit with a removable oral device as described herein may also comprise atenolol (Tenormin). A kit with a removable oral device as described herein may also comprise betaxolol (Kerlone). A kit with a removable oral device as described herein may also comprise bisoprolol fumarate (Zebeta). A kit with a removable oral device as described herein may also comprise cartelol hydrochloride (Cartrol). A kit with a removable oral device as described herein may also comprise metoprolol tartrate (Lopressor). A kit with a removable oral device as described herein may also comprise metoprolol succinate (Toprol-XL). A kit with a removable oral device as described herein may also comprise nadolol (Corgard). A kit with a removable oral device as described herein may also comprise penbutolol sulfate (Levatol). A kit with a removable oral device as described herein may also comprise pindolol (Visken). A kit with a removable oral device as described herein may also comprise propanolol hydrochloride (Inderal). A kit with a removable oral device as described herein may also comprise solotolol hydrochloride (Betapace). A kit with a removable oral device as described herein may also comprise timolol maleate (Blocadren). A kit with a removable oral device as described herein may also comprise, nebivolol (Bystoliv). A kit with a removable oral device as described herein may also comprise a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00497] In some examples, a kit with a removable oral device as described herein may also comprise an acetylcholinesterase inhibitor. For example, a kit with a removable oral device as described herein may also comprise benaxepril hydrochloride (Lotensin). A kit with a removable oral device as described herein may also comprise captopril (Capoten). A kit with a removable oral device as described herein may also comprise enalpril maleate (Vasotec). A kit with a removable oral device as described herein may also comprise fosinopril sodium (Monopril) A kit with a removable oral device as described herein may also comprise lisonopril (Prinivel, Zestril). A kit with a removable oral device as described herein may also comprise moexipril (Univasc). A kit with a removable oral device as described herein may also comprise perindopril (Aceon). A kit with a removable oral device as described herein may also comprise quinapril hydrochloride (Accupril). A kit with a removable oral device as described herein may also comprise ramipril (Altace). A kit with a removable oral device as described herein may also comprise trandolapril (Mavik).

[00498] In certain examples, a kit with a removable oral device as described herein may also comprise an angiotensin II receptor blocker. For example, a kit with a removable oral device as described herein may also comprise candesartan (Atacand). A kit with a removable oral device as described herein may also comprise eprosartan mesylate (Teveten). A kit with a removable oral device as described herein may also comprise irbesartan (Avapro). A kit with a removable oral device as described herein may also comprise losartan potassium (Cozaar). A kit with a removable oral device as described herein may also comprise telmisartan (Micardis). A kit with a removable oral device as described herein may also comprise valsartan (Diovan).

[00499] In certain embodiments, a kit with a removable oral device as described herein may also comprise a calcium channel blocker. For example, a kit with a removable oral device as described herein may also comprise amlodipine besylate (Norvasc, Lotrel). A kit with a removable oral device as described herein may also comprise bepridil (Vasocor). A kit with a removable oral device as described herein may also comprise diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A kit with a removable oral device as described herein may also comprise felodipine (Plendil). A kit with a removable oral device as described herein may also comprise isradipine (DynaCirc, DynaCirc CR). A kit with a removable oral device as described herein may also comprise nicardipine (Cardene SR). A kit with a removable oral device as described herein may also comprise nifedipine (Adalat CC, Procardia XL). A kit with a removable oral device as described herein may also comprise nisoldipine (Sular). A kit with a removable oral device as described herein may also comprise verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00500] In certain embodiments, a kit with a removable oral device as described herein may also comprise an alpha blocker. For example, a kit with a removable oral device as described herein may also comprise doxazosin mesylate (Cardura). A kit with a removable oral device as described herein may also comprise prazosin hydrochloride (Minipress). A kit with a removable oral device as described herein may also comprise terazosin hydrochloride (Hytrin).

[00501] In certain embodiments, a kit with a removable oral device as described herein may also comprise an alpha-2-receptor agonist. For example, a kit with a removable oral device as described herein may also comprise methyldopa.

[00502] In certain embodiments, a kit with a removable oral device as described herein may also comprise combined alpha and beta blockers. For example, a kit with a removable oral device as described herein may also comprise carvedilol (Coreg). A kit with a removable oral device as described herein may also comprise labetalol hydrochloride (Normodyne, Trandate).

[00503] In certain embodiments, a kit with a removable oral device as described herein may also comprise a central agonist. For example, a kit with a removable oral device as described herein may also comprise alpha methyldopa (Aldomet). A kit with a removable oral device as described herein may also comprise clonidine hydrochloride (Catapres). A kit with a removable oral device as described herein may also comprise guanabenz acetate (Wytensin). A kit with a removable oral device as described herein may also comprise guanfacine hydrochloride (Tenex).

[00504] In certain embodiments, a kit with a removable oral device as described herein may also comprise a peripheral adrenergic inhibitor. . For example, a kit with a removable oral device as described herein may also comprise guanadrel (Hylorel). A kit with a removable oral device as described herein may also comprise guanethidine monosulfate (Ismelin). A kit with a removable oral device as described herein may also comprise reserpine (Serpasil).

[00505] In certain embodiments, a kit with a removable oral device as described herein may also comprise a blood vessel dilator (vasodilator). For example, a kit with a removable oral device as described herein may also comprise hydralazine hydrocholoride (Apresoline). A kit with a removable oral device as described herein may also comprise minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with kit with a removable oral device as described herein.

[00506] In some examples, a removable oral device as described herein can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device as described herein is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device as described herein with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00507] In certain examples, a kit with a removable oral device as described herein may also comprise a statin. For example, a kit with a removable oral device as described herein may also comprise an atorvastatin (Lipitor). A kit with a removable oral device as described herein may also comprise a fluvastatin (Lescol). A kit with a removable oral device as described herein may also comprise a rosuvastatin (Crestor). A kit with a removable oral device as described herein may also comprise a simvastatin (Zocor). If desired, two or more of statins can be used in combination with kit with a removable oral device as described herein.

[00508] In certain examples, a kit with a removable oral device as described herein may also comprise a selective cholesterol absorption inhibitor. For example, a kit with a removable oral device as described herein may also comprise ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with kit with a removable oral device as described herein.

[00509] In certain examples, a kit with a removable oral device as described herein may also comprise a resin (bile-acid binding drugs). For example, a kit with a removable oral device as described herein may also comprise cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A kit with a removable oral device as described herein may also comprise colestipol (Colestid®). A kit with a removable oral device as described herein may also comprise colesevelam HCl (WelChol®). If desired, two or more of resins can be used in combination with kit with a removable oral device as described herein.

[00510] In some examples, a kit with a removable oral device as described herein may also comprise lipid lowering therapies. For example, a kit with a removable oral device as described herein may also comprise gemfibrozil (Lopid®). A kit with a removable oral device as described herein may also comprise fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A kit with a removable oral device as described herein may also comprise clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with kit with a removable oral device as described herein. [00511] In some examples, a kit with a removable oral device as described herein may also comprise one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the kit with a removable oral device as described herein can provide both short term and long term treatment. In some examples, a kit with a removable oral device as described herein may also comprise Abatacept (Orencia). A kit with a removable oral device as described herein may also comprise Adalimumab (Humira). A kit with a removable oral device as described herein may also comprise Adalimumab -atto (Amjevita), a biosimilar to Humira. A kit with a removable oral device as described herein may also comprise Anakinra (Kineret). A kit with a removable oral device as described herein may also comprise Certolizumab pegol (Cimzia). A kit with a removable oral device as described herein may also comprise Etanercept (Enbrel). A kit with a removable oral device as described herein may also comprise Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A kit with a removable oral device as described herein may also comprise Golimumab (Simponi, Simponi Aria). A kit with a removable oral device as described herein may also comprise Infliximab (Remicade). A kit with a removable oral device as described herein may also comprise Infliximab -dyyb (Inflectra), a biosimilar to Remicade. A kit with a removable oral device as described herein may also comprise Rituximab (Rituxan). A kit with a removable oral device as described herein may also comprise Tocilizumab (Actemra). A kit with a removable oral device as described herein may also comprise Tofacitinib (Xelj anz). A kit with a removable oral device as described herein may also comprise Natalizumab (Tysabri). A kit with a removable oral device as described herein may also comprise Secukinumab (Cosentyx). A kit with a removable oral device as described herein may also comprise Ustekinumab (Stelara). A kit with a removable oral device as described herein may also comprise Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a kit with a removable oral device as described herein. In addition, two or more of the biological agents can be used in combination with a kit with a removable oral device as described herein.

[00512] In certain configurations, the materials or devices present in the kit in combination with the removable oral device may be colored, may comprise electrical components or other features, device or materials. For example, the pharmacological agent or biological agent may comprise one or more of a bar code, a radio frequency identification tag, a colorant or other features which can permit correlation of a particular pharmacological agent or biological agent to intake by the user. Such features permit intake compliance monitoring to ensure a user is properly taking their prescribed medication. [00513] Combinations Comprising Removable Oral Devices without a Clasping Element

[00514] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device. For example, the removable oral device may comprise a palatal element without any clasping element(s), in which the palatal element is configured to contact a roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. Such removable oral devices without a clasping element can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device without a clasping element can be used in combination with one or more medical devices or implants. For example, a removable oral device without a clasping element can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device without a clasping element in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with removable oral device without a clasping element.

[00515] In other configurations, a removable oral device without a clasping element can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device without a clasping element in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device without a clasping element.

[00516] In some configurations, the removable oral device without a clasping element can be used with other medical devices. For example, removable oral device without a clasping element can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device without a clasping element can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device without a clasping element can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device without a clasping element can be used with a gastric emptying system such as the Aspire assist system. A removable oral device without a clasping element can be used with a CPAP device. A removable oral device without a clasping element can be used with a knee implant. A removable oral device without a clasping element can be used with a hip implant. A removable oral device without a clasping element can be used with an ankle implant. A removable oral device without a clasping element can be used with a coronary, venous or arterial stent. A removable oral device without a clasping element can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device without a clasping element.

[00517] In other configurations, a removable oral device without a clasping element can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device without a clasping element can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device without a clasping element can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device without a clasping element can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device without a clasping element.

[00518] In other configurations, a removable oral device without a clasping element can be used in combination with one or more pharmacological agents, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device without a clasping element is used in combination with a weight loss drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device without a clasping element can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device without a clasping element can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device without a clasping element can be used with a naltrexone hydrochloride and bupropion hydrochloride extended- release tablet such as the drug commercially marketed as Contrave. A removable oral device without a clasping element can be used with a liraglutide [rDNA origin] injection (or with another glucagon -like peptide- 1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device without a clasping element can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device without a clasping element can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device without a clasping element can be used with a lorcaserin HC1 such as the drug commercially marketed as Belviq. A removable oral device without a clasping element can be used with an orlistat such as those commercially marketed as Alli and Xenical. A removable oral device without a clasping element can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device without a clasping element can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device without a clasping element can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device without a clasping element can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device without a clasping element can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device without a clasping element can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device without a clasping element can be used with any two or more of the weight loss drugs listed herein.

[00519] In some examples, a removable oral device without a clasping element can be used in combination with one or more pharmacological agents, e.g., diabetes drugs, used to assist in the treatment of diabetes. Where a removable oral device without a clasping element is used in combination with a diabetes drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device without a clasping element can be used with short acting insulin (Humulin and novolin). A removable oral device without a clasping element can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device without a clasping element can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device without a clasping element can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device without a clasping element can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device without a clasping element can be used with a somatostatin. A removable oral device without a clasping element can be used with a diazoxide. A removable oral device without a clasping element can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device without a clasping element can be used with a dopamine agonist such as bromocriptine. A removable oral device without a clasping element can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin. [00520] In some instances, a removable oral device without a clasping element can be used with glucagon like peptides. For example, a removable oral device without a clasping element can be used with albiglutide (Tanzeum). A removable oral device without a clasping element can be used with dulaglutide (Trulicity). A removable oral device without a clasping element can be used with exenetide (Byetta). A removable oral device without a clasping element can be used with exenatide extended release (Bydureon). A removable oral device without a clasping element can be used with liraglutide (Victoza). A removable oral device without a clasping element can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00521] In certain examples, a removable oral device without a clasping element can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter). For example, a removable oral device without a clasping element can be used with dapagliflozin (Farxiga). A removable oral device without a clasping element can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device without a clasping element can be used with carnagliflozin (Invokana). A removable oral device without a clasping element can be used with canagliflozin-metformin (Invokamet). A removable oral device without a clasping element can be used with empagliflozin (Jardiance). A removable oral device without a clasping element can be used with empagliflozin-linagliptin (Glyxambi).

[00522] In other examples, a removable oral device without a clasping element can be used with a sulfonylurea. For example, a removable oral device without a clasping element can be used with glimepiride (Amaryl). A removable oral device without a clasping element can be used with glimepride-pioglitazone (Duotact). A removable oral device without a clasping element can be used with glimepiride-rosiglitazone (Avendary). A removable oral device without a clasping element can be used with gliclazide, glipizide (Glucotrol). A removable oral device without a clasping element can be used with glipizide-metformin (Metaglip). A removable oral device without a clasping element can be used with glyburide (Diabets, glynase, Micronase). A removable oral device without a clasping element can be used with chloropropamide (Diabinese). A removable oral device without a clasping element can be used with tolazamide (Tolinase). A removable oral device without a clasping element can be used with tolbutamide (Orinase, tol-tab).

[00523] In some instances, a removable oral device without a clasping element can be used with a thiazolidinedione. For example, a removable oral device without a clasping element can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device without a clasping element can be used with rosiglitazone-metformin (Amaryl M).

A removable oral device without a clasping element can be used with pioglitazone (Actos). A removable oral device without a clasping element can be used with pioglitazone-alogliptin (Oseni), A removable oral device without a clasping element can be used with pilglitazone- glimepride (Duetact). A removable oral device without a clasping element can be used with pioglitazone-metformin (Actoplus met, Actoplus met xr). A removable oral device without a clasping element can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device without a clasping element can be used with a glucagon. If desired, a removable oral device without a clasping element can be used with any two, three or more of the diabetes drugs listed herein.

[00524] In some instances, a removable oral device without a clasping element can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs, used to assist in the treatment of high blood pressure. Where a removable oral device without a clasping element is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device without a clasping element with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00525] In certain examples, a removable oral device without a clasping element can be used with diuretic. For example, a removable oral device without a clasping element can be used with chlorthalidone (Hygroton). A removable oral device without a clasping element can be used with chlorothiazide (Diruil). A removable oral device without a clasping element can be used with furosemide (Lasix). A removable oral device without a clasping element can be used with hydrochlorothiazide (Esidrix). A removable oral device without a clasping element can be used with indapamide (Lozol). A removable oral device without a clasping element can be used with metolazone (Mykrox).

[00526] In certain instances, a removable oral device without a clasping element can be used with a loop diuretic such as, for example, bumetanide (Bumex). A removable oral device without a clasping element can be used with combination diuretics. For example, A removable oral device without a clasping element can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device without a clasping element can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device without a clasping element can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00527] In some instances, a removable oral device without a clasping element can be used with a beta blocker. For example, A removable oral device without a clasping element can be used with acebutolol (Sectral). A removable oral device without a clasping element can be used with atenolol (Tenormin). A removable oral device without a clasping element can be used with betaxolol (Kerlone). A removable oral device without a clasping element can be used with bisoprolol fumarate (Zebeta). A removable oral device without a clasping element can be used with cartelol hydrochloride (Cartrol). A removable oral device without a clasping element can be used with metoprolol tartrate (Lopressor). A removable oral device without a clasping element can be used with metoprolol succinate (Toprol-XL). A removable oral device without a clasping element can be used with nadolol (Corgard). A removable oral device without a clasping element can be used with penbutolol sulfate (Levatol). A removable oral device without a clasping element can be used with pindolol (Visken). A removable oral device without a clasping element can be used with propanolol hydrochloride (Inderal). A removable oral device without a clasping element can be used with solotolol hydrochloride (Betapace). A removable oral device without a clasping element can be used with timolol maleate (Blocadren). A removable oral device without a clasping element can be used with, nebivolol (Bystoliv). A removable oral device without a clasping element can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00528] In some examples, a removable oral device without a clasping element can be used with an acetylcholinesterase inhibitor. For example, a removable oral device without a clasping element can be used with benaxepril hydrochloride (Lotensin). A removable oral device without a clasping element can be used with captopril (Capoten). A removable oral device without a clasping element can be used with enalpril maleate (Vasotec). A removable oral device without a clasping element can be used with fosinopril sodium (Monopril) A removable oral device without a clasping element can be used with lisonopril (Prinivel, Zestril). A removable oral device without a clasping element can be used with moexipril (Univasc). A removable oral device without a clasping element can be used with perindopril (Aceon). A removable oral device without a clasping element can be used with quinapril hydrochloride (Accupril). A removable oral device without a clasping element can be used with ramipril (Altace). A removable oral device without a clasping element can be used with trandolapril (Mavik).

[00529] In certain examples, a removable oral device without a clasping element can be used with an angiotensin II receptor blocker. For example, a removable oral device without a clasping element can be used with candesartan (Atacand). A removable oral device without a clasping element can be used with eprosartan mesylate (Teveten). A removable oral device without a clasping element can be used with irbesartan (Avapro). A removable oral device without a clasping element can be used with losartan potassium (Cozaar). A removable oral device without a clasping element can be used with telmisartan (Micardis). A removable oral device without a clasping element can be used with valsartan (Diovan).

[00530] In certain embodiments, a removable oral device without a clasping element can be used with a calcium channel blocker. For example, a removable oral device without a clasping element can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device without a clasping element can be used with bepridil (Vasocor). A removable oral device without a clasping element can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac). A removable oral device without a clasping element can be used with felodipine (Plendil). A removable oral device without a clasping element can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device without a clasping element can be used with nicardipine (Cardene SR). A removable oral device without a clasping element can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device without a clasping element can be used with nisoldipine (Sular). A removable oral device without a clasping element can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00531] In certain embodiments, a removable oral device without a clasping element can be used with an alpha blocker. For example, a removable oral device without a clasping element can be used with doxazosin mesylate (Cardura). A removable oral device without a clasping element can be used with prazosin hydrochloride (Minipress). A removable oral device without a clasping element can be used with terazosin hydrochloride (Hytrin).

[00532] In certain embodiments, a removable oral device without a clasping element can be used with an alpha-2-receptor agonist. For example, a removable oral device without a clasping element can be used with methyldopa.

[00533] In certain embodiments, a removable oral device without a clasping element can be used with combined alpha and beta blockers. For example, a removable oral device without a clasping element can be used with carvedilol (Coreg). A removable oral device without a clasping element can be used with labetalol hydrochloride (Normodyne, Trandate).

[00534] In certain embodiments, a removable oral device without a clasping element can be used with a central agonist. For example, a removable oral device without a clasping element can be used with alpha methyldopa (Aldomet). A removable oral device without a clasping element can be used with clonidine hydrochloride (Catapres). A removable oral device without a clasping element can be used with guanabenz acetate (Wytensin). A removable oral device without a clasping element can be used with guanfacine hydrochloride (Tenex).

[00535] In certain embodiments, a removable oral device without a clasping element can be used with a peripheral adrenergic inhibitor. . For example, a removable oral device without a clasping element can be used with guanadrel (Hylorel). A removable oral device without a clasping element can be used with guanethidine monosulfate (Ismelin). A removable oral device without a clasping element can be used with reserpine (Serpasil).

[00536] In certain embodiments, a removable oral device without a clasping element can be used with a blood vessel dilator (vasodilator). For example, a removable oral device without a clasping element can be used with hydralazine hydrocholoride (Apresoline). A removable oral device without a clasping element can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device without a clasping element.

[00537] In some examples, a removable oral device without a clasping element can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device without a clasping element is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device without a clasping element with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00538] In certain examples, a removable oral device without a clasping element can be used with a statin. For example, a removable oral device without a clasping element can be used with an atorvastatin (Lipitor). A removable oral device without a clasping element can be used with a fluvastatin (Lescol). A removable oral device without a clasping element can be used with a rosuvastatin (Crestor). A removable oral device without a clasping element can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device without a clasping element.

[00539] In certain examples, a removable oral device without a clasping element can be used with a selective cholesterol absorption inhibitor. For example, a removable oral device without a clasping element can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device without a clasping element.

[00540] In certain examples, a removable oral device without a clasping element can be used with a resin (bile-acid binding drugs). For example, a removable oral device without a clasping element can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device without a clasping element can be used with colestipol (Colestid®). A removable oral device without a clasping element can be used with colesevelam HC1 (WelChol®). If desired, two or more of resins can be used in combination with removable oral device without a clasping element.

[00541] In some examples, a removable oral device without a clasping element can be used with lipid lowering therapies. For example, a removable oral device without a clasping element can be used with gemfibrozil (Lopid®). A removable oral device without a clasping element can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device without a clasping element can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device without a clasping element.

[00542] In some examples, a removable oral device without a clasping element can be used with one or more biological agents such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device without a clasping element can provide both short term and long term treatment. In some examples, a removable oral device without a clasping element can be used with Abatacept (Orencia). A removable oral device without a clasping element can be used with Adalimumab (Humira). A removable oral device without a clasping element can be used with Adalimumab-atto (Amjevita), a biosimilar to Humira. A removable oral device without a clasping element can be used with Anakinra (Kineret). A removable oral device without a clasping element can be used with Certolizumab pegol (Cimzia). A removable oral device without a clasping element can be used with Etanercept (Enbrel). A removable oral device without a clasping element can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device without a clasping element can be used with Golimumab (Simponi, Simponi Aria). A removable oral device without a clasping element can be used with Infliximab (Remicade). A removable oral device without a clasping element can be used with Infliximab- dyyb (Inflectra), a biosimilar to Remicade. A removable oral device without a clasping element can be used with Rituximab (Rituxan). A removable oral device without a clasping element can be used with Tocilizumab (Actemra). A removable oral device without a clasping element can be used with Tofacitinib (Xeljanz). A removable oral device without a clasping element can be used with Natalizumab (Tysabri). A removable oral device without a clasping element can be used with Secukinumab (Cosentyx). A removable oral device without a clasping element can be used with Ustekinumab (Stelara). A removable oral device without a clasping element can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device without a clasping element. In addition, two or more of the biological agents can be used in combination with a removable oral device without a clasping element.

[00543] Combinations Comprising Removable Oral Devices with a Radio Frequency

Receiver

[00544] Certain configurations described herein may use one or more of a pharmacological agent, implant or other material or device in combination with a removable oral device. For example, the removable oral device may comprise a palatal element comprising a radio frequency receiver which can read a radio frequency tag, e.g., a chip or transmitter which can emit radio frequencies at a desired frequency, on/in a drug or other material. The palatal element is configured to contact a roof of a user's mouth at a palatal surface. The palatal element comprises a body comprising a thickness configured to lower a vaulted area of the roof of the mouth to decrease an overall oral volume of the mouth to a first oral volume. Such removable oral devices comprising a radio frequency receiver can be used in combination with one or more of a pharmacological agent (or multiple pharmacological agents), an implant, a medical device or one or more surgical techniques. In certain configurations, the removable oral device comprising a radio frequency receiver can be used in combination with one or more medical devices or implants. For example, a removable oral device comprising a radio frequency receiver can be used with an endoscopic balloon including single balloons, dual balloons and multiple balloons to treat, for example, obesity or being overweight. The use of a removable oral device in combination with an endoscopic balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or an endoscopic balloon alone. Illustrative endoscopic balloons include those commercially marketed under the names Obalon balloon, Obera Intragastric balloon, and Reshape Dual Balloon. In addition, two or more of the endoscopic balloons agents can be used in combination with removable oral device comprising a radio frequency receiver.

[00545] In other configurations, a removable oral device comprising a radio frequency receiver can be used with a swallowable balloon to treat, for example, obesity or being overweight. The use of a removable oral device comprising a radio frequency receiver in combination with a swallowable balloon can increase the rate of weight loss, maintain weight loss and/or alter eating behaviors in a more effective manner than just using a removable oral device or a swallowable balloon alone. Illustrative swallowable balloons include those commercially marketed under the names Obalon. If desired, two or more of swallowable balloons can be used in combination with removable oral device comprising a radio frequency receiver.

[00546] In some configurations, the removable oral device comprising a radio frequency receiver can be used with other medical devices. For example, removable oral device comprising a radio frequency receiver can be used with an endoscopic endoluminal sleeve such as Endobarrier sleeve. A removable oral device comprising a radio frequency receiver can be used with an electrical stimulation systems such as the Maestro rechargeable system. A removable oral device comprising a radio frequency receiver can be used with a gastric band such as Lap Band, Realize Gastric Band. A removable oral device comprising a radio frequency receiver can be used with a gastric emptying system such as the Aspire assist system. A removable oral device comprising a radio frequency receiver can be used with a CPAP device. A removable oral device comprising a radio frequency receiver can be used with a knee implant. A removable oral device comprising a radio frequency receiver can be used with a hip implant. A removable oral device comprising a radio frequency receiver can be used with an ankle implant. A removable oral device comprising a radio frequency receiver can be used with a coronary, venous or arterial stent. A removable oral device comprising a radio frequency receiver can be used with angioplasty devices. If desired, two or more of medical devices can be used in combination with removable oral device comprising a radio frequency receiver.

[00547] In other configurations, a removable oral device comprising a radio frequency receiver can be used pre-operatively and/or post-operatively with one or more surgical methods or techniques. A removable oral device comprising a radio frequency receiver can be used with gastric bypass surgery. A removable oral device can be used with sleeve gastrectomy. A removable oral device comprising a radio frequency receiver can be used with bilio pancreatic diversion w/duodenal switch. A removable oral device comprising a radio frequency receiver can be used with open heart and percutaneous surgery. If desired, two or more of surgical methods can be used in combination with removable oral device comprising a radio frequency receiver.

[00548] In other configurations, a removable oral device comprising a radio frequency receiver can be used in combination with one or more pharmacological agents comprising a radio frequency tag, e.g., weight loss drugs, used to assist in weight loss. Where a removable oral device comprising a radio frequency receiver is used in combination with a weight loss drug comprising a radio frequency tag, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a radio frequency receiver can be used with a weight loss drug comprising a primary amine stimulant. A removable oral device comprising a radio frequency receiver can be used with a primary amine stimulant where the primary amine is positioned two carbons away from a benzyl group to enhance activity, e.g., in phentermine, amphetamine, etc. A removable oral device comprising a radio frequency receiver can be used with a naltrexone hydrochloride and bupropion hydrochloride extended-release tablet such as the drug commercially marketed as Contrave. A removable oral device comprising a radio frequency receiver can be used with a liraglutide [rDNA origin] injection (or with another glucagon-like peptide- 1 (GLP-1) receptor agonist) such as the drug commercially marketed as Saxenda. A removable oral device comprising a radio frequency receiver can be used with a phentermine such as the drugs commercially marketed as Adapex, Suprenza. A removable oral device comprising a radio frequency receiver can be used with a phentermine + topiramate such as the drug commercially marketed as Qsymia. A removable oral device comprising a radio frequency receiver can be used with a lorcaserin HCl such as the drug commercially marketed as Belviq. A removable oral device comprising a radio frequency receiver can be used with an orlistat such as those commercially marketed as Alii and Xenical. A removable oral device comprising a radio frequency receiver can be used with a lisdexamfetamine dimesylate such as the drug commercially marketed as Vyvanse. A removable oral device comprising a radio frequency receiver can be used with a sibutramine such as the drug commercially marketed as Meridia. A removable oral device comprising a radio frequency receiver can be used with a phendimetrazine such as the drug commercially marketed as Bontril. A removable oral device comprising a radio frequency receiver can be used with a methamphetamine such as the one commercially marketed as Desoxyn. A removable oral device comprising a radio frequency receiver can be used with a benzphetamine such as the drug commercially marketed as Didrex. A removable oral device comprising a radio frequency receiver can be used with a diethylpropion such as the drug commercially marketed as Tenuate. If desired, a removable oral device comprising a radio frequency receiver can be used with any two or more of the weight loss drugs listed herein.

[00549] In some examples, a removable oral device comprising a radio frequency receiver can be used in combination with one or more pharmacological agents, e.g., diabetes drugs comprising a radio frequency tag, used to assist in the treatment of diabetes. Where a removable oral device comprising a radio frequency receiver is used in combination with a diabetes drug comprising a radio frequency tag, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. A removable oral device comprising a radio frequency receiver can be used with short acting insulin (Humulin and novolin). A removable oral device comprising a radio frequency receiver can be used with rapid acting insulin (Novolog, flexpen, Apidra, Humalog). A removable oral device comprising a radio frequency receiver can be used with intermediate acting insulin, e.g., an isophane insulin suspension or an insulin zinc suspension such as Humalin N, Novolin N. A removable oral device comprising a radio frequency receiver can be used with long acting insulin, e.g., an extended insulin zinc suspension or Insulin degludec (Tresiba), Insulin Determir (Levemir), Insulin Glargine (Lantus), or Insulin glargine (Toujeo). A removable oral device comprising a radio frequency receiver can be used with mixtures of insulins (Novolog Mix, Humolog mix). A removable oral device comprising a radio frequency receiver can be used with a somatostatin. A removable oral device comprising a radio frequency receiver can be used with a diazoxide. A removable oral device comprising a radio frequency receiver can be used with a biguanide such as metformin which is commercially marketed under various names including Fortamet, Glucophage, Glucophage XR, Lumetza and Riomet. A removable oral device comprising a radio frequency receiver can be used with a dopamine agonist such as bromocriptine. A removable oral device comprising a radio frequency receiver can be used with a dipeptidyl peptidase 4 (DDP-4 inhibitor) such as sitagliptin or vildagliptin.

[00550] In some instances, a removable oral device comprising a radio frequency receiver can be used with glucagon like peptides comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with albiglutide (Tanzeum). A removable oral device comprising a radio frequency receiver can be used with dulaglutide (Trulicity). A removable oral device comprising a radio frequency receiver can be used with exenetide (Byetta). A removable oral device comprising a radio frequency receiver can be used with exenatide extended release (Bydureon). A removable oral device comprising a radio frequency receiver can be used with liraglutide (Victoza). A removable oral device comprising a radio frequency receiver can be used with a meglitinide such as nateglinide (Starlix), repaglinide (Prandin) and repaglinide-metformin (Prandimet).

[00551] In certain examples, a removable oral device comprising a radio frequency receiver can be used with a SGLT 2 Inhibitor (Sodium Glucose Transporter) comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with dapagliflozin (Farxiga). A removable oral device comprising a radio frequency receiver can be used with dapagliflozin-metformin (Xigduo xr). A removable oral device comprising a radio frequency receiver can be used with carnagliflozin (Invokana). A removable oral device comprising a radio frequency receiver can be used with canagliflozin-metformin (Invokamet). A removable oral device comprising a radio frequency receiver can be used with empagliflozin (Jardiance). A removable oral device comprising a radio frequency receiver can be used with empagliflozin-linagliptin (Glyxambi). [00552] In other examples, a removable oral device comprising a radio frequency receiver can be used with a sulfonylurea comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with glimepiride (Amaryl). A removable oral device comprising a radio frequency receiver can be used with glimepride- pioglitazone (Duotact). A removable oral device comprising a radio frequency receiver can be used with glimepiride-rosiglitazone (Avendary). A removable oral device comprising a radio frequency receiver can be used with gliclazide, glipizide (Glucotrol). A removable oral device comprising a radio frequency receiver can be used with glipizide-metformin (Metaglip). A removable oral device comprising a radio frequency receiver can be used with glyburide (Diabets, glynase, Micronase). A removable oral device comprising a radio frequency receiver can be used with chloropropamide (Diabinese). A removable oral device comprising a radio frequency receiver can be used with tolazamide (Tolinase). A removable oral device comprising a radio frequency receiver can be used with tolbutamide (Orinase, tol-tab).

[00553] In some instances, a removable oral device comprising a radio frequency receiver can be used with a thiazolidinedione comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with rosiglitazone (Avandia), rosiglitazone-glimepride (Avandaryl). A removable oral device comprising a radio frequency receiver can be used with rosiglitazone-metformin (Amaryl M). A removable oral device comprising a radio frequency receiver can be used with pioglitazone (Actos). A removable oral device comprising a radio frequency receiver can be used with pioglitazone- alogliptin (Oseni), A removable oral device comprising a radio frequency receiver can be used with pilglitazone-glimepride (Duetact). A removable oral device comprising a radio frequency receiver can be used with pioglitazone-metformin (Actoplus met, Actoplus met xr). A removable oral device comprising a radio frequency receiver can be used with an amylinomimetic drugs such as pramlintide (Symlinpen 120, 60). A removable oral device comprising a radio frequency receiver can be used with a glucagon. If desired, a removable oral device comprising a radio frequency receiver can be used with any two, three or more of the diabetes drugs listed herein.

[00554] In some instances, a removable oral device comprising a radio frequency receiver can be used in combination with one or more pharmacological agents, e.g., high blood pressure drugs comprising a radio frequency tag, used to assist in the treatment of high blood pressure. Where a removable oral device comprising a radio frequency receiver is used in combination with a high blood pressure drug, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising a radio frequency receiver with the high blood pressure drug, immediate pharmacological effects to reduce the blood pressure can be obtained with the drug and longer term effects of reduced blood pressure can be obtained using the removable oral device to control weight and/or promote weight loss.

[00555] In certain examples, a removable oral device comprising a radio frequency receiver can be used with diuretic comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with chlorthalidone (Hygroton). A removable oral device comprising a radio frequency receiver can be used with chlorothiazide (Diruil). A removable oral device comprising a radio frequency receiver can be used with furosemide (Lasix). A removable oral device comprising a radio frequency receiver can be used with hydrochlorothiazide (Esidrix). A removable oral device comprising a radio frequency receiver can be used with indapamide (Lozol). A removable oral device comprising a radio frequency receiver can be used with metolazone (Mykrox).

[00556] In certain instances, a removable oral device comprising a radio frequency receiver can be used with a loop diuretic such as, for example, bumetanide (Bumex) comprising a radio frequency tag. A removable oral device comprising a radio frequency receiver can be used with combination diuretics. For example, A removable oral device comprising a radio frequency receiver can be used with amiloride + hydrochlorothiazide (Moduretic). A removable oral device comprising a radio frequency receiver can be used with spironolactone + hydrochlorothiazide (Aldactazide). A removable oral device comprising a radio frequency receiver can be used with triamterene + hydrochlorothiazide (Dyazide, Maxzide).

[00557] In some instances, a removable oral device comprising a radio frequency receiver can be used with a beta blocker comprising a radio frequency tag. For example, A removable oral device comprising a radio frequency receiver can be used with acebutolol (Sectral). A removable oral device comprising a radio frequency receiver can be used with atenolol (Tenormin). A removable oral device comprising a radio frequency receiver can be used with betaxolol (Kerlone). A removable oral device comprising a radio frequency receiver can be used with bisoprolol fumarate (Zebeta). A removable oral device comprising a radio frequency receiver can be used with cartelol hydrochloride (Cartrol). A removable oral device comprising a radio frequency receiver can be used with metoprolol tartrate (Lopressor). A removable oral device comprising a radio frequency receiver can be used with metoprolol succinate (Toprol- XL). A removable oral device comprising a radio frequency receiver can be used with nadolol (Corgard). A removable oral device comprising a radio frequency receiver can be used with penbutolol sulfate (Levatol). A removable oral device comprising a radio frequency receiver can be used with pindolol (Visken). A removable oral device comprising a radio frequency receiver can be used with propanolol hydrochloride (Inderal). A removable oral device comprising a radio frequency receiver can be used with solotolol hydrochloride (Betapace). A removable oral device comprising a radio frequency receiver can be used with timolol maleate (Blocadren). A removable oral device comprising a radio frequency receiver can be used with, nebivolol (Bystoliv). A removable oral device comprising a radio frequency receiver can be used with a combination beta blocker/diuretic such as, for example, hydrochlorothiazide and bisoprolol (Ziac).

[00558] In some examples, a removable oral device comprising a radio frequency receiver can be used with an acetylcholinesterase inhibitor comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with benaxepril hydrochloride (Lotensin). A removable oral device comprising a radio frequency receiver can be used with captopril (Capoten). A removable oral device comprising a radio frequency receiver can be used with enalpril maleate (Vasotec). A removable oral device comprising a radio frequency receiver can be used with fosinopril sodium (Monopril) A removable oral device comprising a radio frequency receiver can be used with lisonopril (Prinivel, Zestril). A removable oral device comprising a radio frequency receiver can be used with moexipril (Univasc). A removable oral device comprising a radio frequency receiver can be used with perindopril (Aceon). A removable oral device comprising a radio frequency receiver can be used with quinapril hydrochloride (Accupril). A removable oral device comprising a radio frequency receiver can be used with ramipril (Altace). A removable oral device comprising a radio frequency receiver can be used with trandolapril (Mavik).

[00559] In certain examples, a removable oral device comprising a radio frequency receiver can be used with an angiotensin II receptor blocker comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with candesartan (Atacand). A removable oral device comprising a radio frequency receiver can be used with eprosartan mesylate (Teveten). A removable oral device comprising a radio frequency receiver can be used with irbesartan (Avapro). A removable oral device comprising a radio frequency receiver can be used with losartan potassium (Cozaar). A removable oral device comprising a radio frequency receiver can be used with telmisartan (Micardis). A removable oral device comprising a radio frequency receiver can be used with valsartan (Diovan).

[00560] In certain embodiments, a removable oral device comprising a radio frequency receiver can be used with a calcium channel blocker comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with amlodipine besylate (Norvasc, Lotrel). A removable oral device comprising a radio frequency receiver can be used with bepridil (Vasocor). A removable oral device comprising a radio frequency receiver can be used with diltiazem hydrochloride (Cardizem CD, Cardizem SR,

Dilacor XR, Tiazac). A removable oral device comprising a radio frequency receiver can be used with felodipine (Plendil). A removable oral device comprising a radio frequency receiver can be used with isradipine (DynaCirc, DynaCirc CR). A removable oral device comprising a radio frequency receiver can be used with nicardipine (Cardene SR). A removable oral device comprising a radio frequency receiver can be used with nifedipine (Adalat CC, Procardia XL). A removable oral device comprising a radio frequency receiver can be used with nisoldipine (Sular). A removable oral device comprising a radio frequency receiver can be used with verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan).

[00561] In certain embodiments, a removable oral device comprising a radio frequency receiver can be used with an alpha blocker comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with doxazosin mesylate (Cardura). A removable oral device comprising a radio frequency receiver can be used with prazosin hydrochloride (Minipress). A removable oral device comprising a radio frequency receiver can be used with terazosin hydrochloride (Hytrin).

[00562] In certain embodiments, a removable oral device comprising a radio frequency receiver can be used with an alpha-2-receptor agonist comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with methyldopa.

[00563] In certain embodiments, a removable oral device comprising a radio frequency receiver can be used with combined alpha and beta blockers comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with carvedilol (Coreg). A removable oral device comprising a radio frequency receiver can be used with labetalol hydrochloride (Normodyne, Trandate).

[00564] In certain embodiments, a removable oral device comprising a radio frequency receiver can be used with a central agonist comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with alpha methyldopa (Aldomet). A removable oral device comprising a radio frequency receiver can be used with clonidine hydrochloride (Catapres). A removable oral device comprising a radio frequency receiver can be used with guanabenz acetate (Wytensin). A removable oral device comprising a radio frequency receiver can be used with guanfacine hydrochloride (Tenex).

[00565] In certain embodiments, a removable oral device comprising a radio frequency receiver can be used with a peripheral adrenergic inhibitor comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with guanadrel (Hylorel). A removable oral device comprising a radio frequency receiver can be used with guanethidine monosulfate (Ismelin). A removable oral device comprising a radio frequency receiver can be used with reserpine (Serpasil). [00566] In certain embodiments, a removable oral device comprising a radio frequency receiver can be used with a blood vessel dilator (vasodilator) comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with hydralazine hydrocholoride (Apresoline). A removable oral device comprising a radio frequency receiver can be used with minoxidil (Loniten). If desired, two or more of high blood pressure drugs can be used in combination with removable oral device comprising a radio frequency receiver.

[00567] In some examples, a removable oral device comprising a radio frequency receiver can be used in combination with one or more pharmacological agents, e.g., a cholesterol or lipid lowering drug comprising a radio frequency tag, used to assist in the treatment of high cholesterol or high HDL's. Where a removable oral device comprising a radio frequency receiver is used in combination with a cholesterol or lipid lowering agent, the removable oral device can be configured, for example, to reduce the overall available food volume of the mouth. By using the removable oral device comprising a radio frequency receiver with the cholesterol or lipid lowering agent, immediate pharmacological effects to reduce the cholesterol or lipid levels can be obtained with the drug, and longer term effects of reduced cholesterol and lipid levels can be obtained using the removable oral device. In some examples, the amount of the cholesterol or lipid lowering drug may be gradually reduced during the course of treatment until the human can eventually discontinue treatment of the drug once the desired cholesterol or lipid levels are reached and/or once a desired weight, BMI or body fat percentage is reached.

[00568] In certain examples, a removable oral device comprising a radio frequency receiver can be used with a statin comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with an atorvastatin (Lipitor). A removable oral device comprising a radio frequency receiver can be used with a fluvastatin (Lescol). A removable oral device comprising a radio frequency receiver can be used with a rosuvastatin (Crestor). A removable oral device comprising a radio frequency receiver can be used with a simvastatin (Zocor). If desired, two or more of statins can be used in combination with removable oral device comprising a radio frequency receiver.

[00569] In certain examples, a removable oral device comprising a radio frequency receiver can be used with a selective cholesterol absorption inhibitor comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with ezetimibe (Zetia). If desired, two or more of selective cholesterol absorption inhibitors can be used in combination with removable oral device comprising a radio frequency receiver. [00570] In certain examples, a removable oral device comprising a radio frequency receiver can be used with a resin (bile-acid binding drugs) comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light). A removable oral device comprising a radio frequency receiver can be used with colestipol (Colestid®). A removable oral device comprising a radio frequency receiver can be used with colesevelam HCl (WelChol®). If desired, two or more of resins can be used in combination with removable oral device comprising a radio frequency receiver.

[00571] In some examples, a removable oral device comprising a radio frequency receiver can be used with lipid lowering therapies comprising a radio frequency tag. For example, a removable oral device comprising a radio frequency receiver can be used with gemfibrozil (Lopid®). A removable oral device comprising a radio frequency receiver can be used with fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™). A removable oral device comprising a radio frequency receiver can be used with clofibrate (Atromid-S). If desired, two or more of lipid lowering therapies can be used in combination with removable oral device comprising a radio frequency receiver.

[00572] In some examples, a removable oral device comprising a radio frequency receiver can be used with one or more biological agents comprising a radio frequency tag such as, for example, a monoclonal or polyclonal antibody. In some examples, people suffering from autoimmune diseases, particularly rheumatoid arthritis, can often benefit from weight loss. The combination of the biological agent and the removable oral device comprising a radio frequency receiver can provide both short term and long term treatment. In some examples, a removable oral device comprising a radio frequency receiver can be used with Abatacept (Orencia). A removable oral device comprising a radio frequency receiver can be used with Adalimumab (Humira). A removable oral device comprising a radio frequency receiver can be used with Adalimumab-atto (Amjevita), a biosimilar to Humira. A removable oral device comprising a radio frequency receiver can be used with Anakinra (Kineret). A removable oral device comprising a radio frequency receiver can be used with Certolizumab pegol (Cimzia). A removable oral device comprising a radio frequency receiver can be used with Etanercept (Enbrel). A removable oral device comprising a radio frequency receiver can be used with Etanercept-szzs (Erelzi), a biosimilar to Enbrel. A removable oral device comprising a radio frequency receiver can be used with Golimumab (Simponi, Simponi Aria). A removable oral device comprising a radio frequency receiver can be used with Infliximab (Remicade). A removable oral device comprising a radio frequency receiver can be used with Infliximab -dyyb

(Inflectra), a biosimilar to Remicade. A removable oral device comprising a radio frequency receiver can be used with Rituximab (Rituxan). A removable oral device comprising a radio frequency receiver can be used with Tocilizumab (Actemra). A removable oral device comprising a radio frequency receiver can be used with Tofacitinib (Xeljanz). A removable oral device comprising a radio frequency receiver can be used with Natalizumab (Tysabri). A removable oral device comprising a radio frequency receiver can be used with Secukinumab (Cosentyx). A removable oral device comprising a radio frequency receiver can be used with Ustekinumab (Stelara). A removable oral device comprising a radio frequency receiver can be used with Ixekizumab (Taltz). Biosimilars to any of the above illustrative biological agents can also be used in combination with a removable oral device comprising a radio frequency receiver. In addition, two or more of the biological agents can be used in combination with a removable oral device comprising a radio frequency receiver.

[00573] When introducing elements of the examples disclosed herein, the articles "a," "an," "the" and "said" are intended to mean that there are one or more of the elements. The terms "comprising," "including" and "having" are intended to be open-ended and mean that there may be additional elements other than the listed elements. It will be recognized by the person of ordinary skill in the art, given the benefit of this disclosure, that various components of the examples can be interchanged or substituted with various components in other examples.

[00574] Although certain aspects, examples and embodiments have been described above, it will be recognized by the person of ordinary skill in the art, given the benefit of this disclosure, that additions, substitutions, modifications, and alterations of the disclosed illustrative aspects, examples and embodiments are possible.

Claims

What is claimed is:

1. A system or kit comprising:

a removable oral device comprising a palatal element coupled to a clasping element, the palatal element configured to engage a roof of a user's mouth and reduce an oral volume of the mouth during chewing of food, the clasping element configured to assist in removal of the removable oral device from the user's mouth; and

a pharmacological agent.

2. The system or kit of claim 1, wherein the pharmacological agent is a weight loss drug.

3. The system of claim 2, wherein the weight loss drug is a stimulant.

4. The system or kit of claim 1, wherein the pharmacological agent is a diabetes drug.

5. The system or kit of claim 4, wherein the diabetes drug comprises an insulin.

6. The system or kit of claim 1, wherein the pharmacological agent is a high blood pressure drug.

7. The system of kit of claim 6, wherein the wherein the high blood pressure drug comprises a diuretic, beta blocker or an acetylcholinesterase inhibitor.

8. The system or kit of claim 1, wherein the pharmacological agent is a cholesterol or lipd lowering drug.

9. The system or kit of claim 1, wherein the cholesterol lowering drug comprises a statin.

10. The system or kit of claim 1, wherein the pharmacological agent comprises a biological agent.

11. The system or kit of claim 1, wherein the biological agent comprises an antibody.

12. The system or kit of claim 1, wherein the pharmacological agent comprises at least two different pharmacological agents.

13. The system or kit of claim 1, wherein the pharmacological agent comprise a bar code present on a surface.

14. The system or kit of claim 13, further comprising instructions for using the removable oral device to monitor intake compliance of the pharmacological agent comprising the bar code.

15. The system or kit of claim 13, in which the pharmacological agent is an opioid.

16. The system or kit of claim 1, wherein the pharmacological agent comprises a radio frequency tag.

17. The system or kit of claim 16, further comprising instructions for using the removable oral device to monitor intake compliance of the pharmacological agent comprising the radio frequency tag.

18. The system or kit of claim 16, in which the pharmacological agent is an opioid.

19. The system or kit of claim 16, wherein the removable oral device is configured to not alter a position of teeth of the user.

20. The system or kit of claim 16, wherein the removable oral device is configured to not retain a position of teeth of the user.

21. The system or kit of claim 1, wherein the pharmacological agent comprises a colorant.

22. The system or kit of claim 21, further comprising instructions for using the removable oral device to monitor intake compliance of the pharmacological agent comprising the colorant.

23. The system or kit of claim 21, in which the pharmacological agent is an opioid.

24. The system or kit of claim 1, wherein the removable oral device is configured to not alter a position of teeth of the user.

25. The system or kit of claim 1, wherein the removable oral device is configured to not retain a position of teeth of the user.

26. The system or kit of any of claims 1-25, wherein the removable oral device is not designed to correct tongue thrust.

27. The system or kit of any of claims 1-25, wherein the removable oral device is not designed to treat sleep apnea.

28. A method of treating high cholesterol comprising providing a removable oral device as described herein and providing at least one cholesterol or lipid lowering drug.

29. A method of treating high cholesterol comprising providing a removable oral device as described herein and providing at least one diabetic drug.

30 A method of treating high cholesterol comprising providing a removable oral device as described herein and providing at least one weight loss drug.

31. A method of treating high cholesterol comprising providing a removable oral device as described herein and providing at least one biological agent.

32. A system or kit comprising:

an endoscopic balloon.

33. The system or kit of claim 32, wherein the removable oral device is configured to not alter a position of teeth of the user.

34. The system or kit of claim 32, wherein the removable oral device is configured to not retain a position of teeth of the user.

35. A system or kit comprising:

a swallowable balloon.

36. The system or kit of claim 35, wherein the removable oral device is configured to not alter a position of teeth of the user.

37. The system or kit of claim 35, wherein the removable oral device is configured to not retain a position of teeth of the user.

38. A system or kit comprising:

a gastric band.

39. The system or kit of claim 38, wherein the removable oral device is configured to not alter a position of teeth of the user.

40. The system or kit of claim 38, wherein the removable oral device is configured to not retain a position of teeth of the user.

41. A system or kit comprising:

a removable oral device comprising a palatal element coupled to a clasping element, the palatal element configured to engage a roof of a human's mouth and reduce an oral volume of the mouth during chewing of food, the clasping element configured to assist in removal of the removable oral device from the user's mouth; and

an electrical stimulation system configured to provide a stimulus to induce a sensation of fullness in a stomach of the human.

42. The system or kit of claim 41, wherein the removable oral device is configured to not alter a position of teeth of the user.

43. The system or kit of claim 41, wherein the removable oral device is configured to not retain a position of teeth of the user.

44. A system or kit comprising:

a gastric emptying system configured to reduce absorption of the chewed food in the stomach.

45. The system or kit of claim 44, wherein the removable oral device is configured to not alter a position of teeth of the user.

46. The system or kit of claim 44, wherein the removable oral device is configured to not retain a position of teeth of the user.

47. A system or kit comprising:

instructions for using the removable oral device with a surgical method configured to reduce stomach volume.

48. The system or kit of claim 47, wherein the removable oral device is configured to not alter a position of teeth of the user.

49. The system or kit of claim 47, wherein the removable oral device is configured to not retain a position of teeth of the user.

50. A system or kit comprising:

instructions for using the removable oral device with a stent to increase arterial or venous blood flow in the human.

51. The system or kit of claim 50, wherein the removable oral device is configured to not alter a position of teeth of the user.

52. The system or kit of claim 50, wherein the removable oral device is configured to not retain a position of teeth of the user.

53. A system or kit comprising:

instructions for using the removable oral device with an angioplasty procedure to increase arterial or venous blood flow in the human.

54. The system or kit of claim 53, wherein the removable oral device is configured to not alter a position of teeth of the user.

55. The system or kit of claim 53, wherein the removable oral device is configured to not retain a position of teeth of the user.

56. A system or kit comprising:

instructions for using the removable oral device with an implant to treat a joint disorder of the human.

157. The system or kit of claim 56, wherein the removable oral device is configured to not alter a position of teeth of the user.

58. The system or kit of claim 56, wherein the removable oral device is configured to not retain a position of teeth of the user.

59. A system or kit comprising:

60. The system or kit of claim 59, wherein the removable oral device is configured to not alter a position of teeth of the user.

61 The system or kit of claim 59, wherein the removable oral device is configured to not retain a position of teeth of the user.