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WO2018176895A1 - 一种包含硫代氨基甲酸酯类化合物和噻苯隆的农药组合物 - Google Patents

一种包含硫代氨基甲酸酯类化合物和噻苯隆的农药组合物 Download PDF

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Publication number
WO2018176895A1
WO2018176895A1 PCT/CN2017/114516 CN2017114516W WO2018176895A1 WO 2018176895 A1 WO2018176895 A1 WO 2018176895A1 CN 2017114516 W CN2017114516 W CN 2017114516W WO 2018176895 A1 WO2018176895 A1 WO 2018176895A1
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WIPO (PCT)
Prior art keywords
thiabendazole
active component
composition according
pesticide
zinc
Prior art date
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PCT/CN2017/114516
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English (en)
French (fr)
Inventor
季红进
仲汉根
花伟
王莹
王英
韦建峰
季定根
Original Assignee
江苏辉丰生物农业股份有限公司
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Publication of WO2018176895A1 publication Critical patent/WO2018176895A1/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
    • A01N47/14—Di-thio analogues thereof

Definitions

  • the present invention belongs to the field of agricultural plant protection, and more particularly to a pesticidal composition having improved properties, and more particularly to a composition comprising a thiocarbamate compound and a thiazole pesticide.
  • Mancozeb is a kind of protective fungicide with high efficiency, low toxicity, low residue and wide spectrum of sterilization. It is mainly used to control various fungal diseases such as wheat, fruits and vegetables.
  • the bactericidal mechanism can form a dense protective membrane of gas, water and light on the surface of the leaves and fruits after use, inhibiting the germination and invasion of the spores of the bacteria, and destroying the activities of various enzymes required for the normal physiological metabolism of the bacteria, thereby To achieve the purpose of sterilization and disease prevention.
  • Meiram is an excellent protective fungicide and a low-toxic pesticide. Because of its wide range of sterilization and resistance to resistance, the control effect is obviously superior to other similar fungicides, so the international use has always been a large tonnage product. It is currently a substitute for other protective fungicides. Most of the domestic compound fungicides are prepared by processing mancozeb, but manganese-zinc preparations cause poisoning of trace elements in crops. Black spot disease, apple spotted leaf disease, melon vegetable disease, downy mildew, field crop rust and other effects are remarkable, and no other fungicide can effectively control the occurrence of disease, and the quality is stable and reliable.
  • Propineb is a broad-spectrum, fast-acting protective fungicide. Suitable for crops such as tomatoes, cabbage, cucumbers, mangoes and flowers. Control cabbage downy mildew, cucumber downy mildew, tomato early and late blight, mango anthracnose. Propionate zinc is a fast-acting, long-lasting, broad-spectrum protective fungicide with good protection against downy mildew of vegetables, tobacco, hops and other crops, as well as early and late blight of tomato and potato, and Powdery mildew, rust and diseases caused by Botrytis are also inhibited. Safe for crops at recommended doses.
  • Pyraclostrobin is a new type of high-efficiency plant growth regulator. When it is absorbed by plants, it can promote the separation of petioles and stems and form natural shedding. It can be widely used in pesticides and fertilizers. It has strong biological activity, and its ability to induce plant cell division and callus formation is many times higher than that of general cytokinins. Improve crop absorptive capacity and increase photosynthesis, so as to increase production and enhance the purpose. It can be used in various kinds of melons, fruits, vegetables, seedlings, flowers, food, tobacco and other crops, and can also be used for tissue culture, genetic engineering, etc. Significantly improved in production Crop yield, quality improvement, low dosage, no pollution to the ecological environment, non-toxic to humans, animals, birds, bees and natural enemies.
  • Another object of the present invention is to provide a process for the preparation of a bactericidal composition comprising two active ingredients A and B and for use in the field of disease prevention or disease resistance or for promoting plant growth in the agricultural field.
  • the object of the invention can be achieved by the following measures:
  • a pesticidal composition comprising two active components A and B, wherein the active component A is a thiocarbamate compound selected from the group consisting of mancozeb, dexamethasone and propyl zinc Any one of the compounds, wherein the active component B is thidiazuron.
  • the active component A is a thiocarbamate compound selected from the group consisting of mancozeb, dexamethasone and propyl zinc Any one of the compounds, wherein the active component B is thidiazuron.
  • the weight ratio between the two components is (80 to 5000):1, and in order to further enhance the effect of the composition of the present invention, the weight ratio between the two components is optimized to be (200 to 4500):1, further preferably (500) ⁇ 4500):1.
  • the weight ratio between the two components of A and B can be arbitrarily adjusted within the range of the following ratios: 80:1, 90:1, 100:1, 110:1, 120:1 , 130:1, 140:1, 150:1, 160:1, 170:1, 180:1, 190:1, 200:1, 210:1, 220:1, 230:1, 240:1, 250 1, 260: 1, 270: 1, 280: 1, 290: 1, 300: 1, 310: 1, 320: 1, 330: 1, 340: 1, 350: 1, 360: 1, 370: 1 380:1, 390:1, 400:1, 410:1, 420:1, 430:1, 440:1, 450:1, 460:1, 470:1, 480:1, 490:1, 500 1, 510: 1, 520: 1, 530: 1, 540: 1, 550: 1, 560: 1, 570: 1, 580: 1, 590: 1, 600: 1, 610: 1, 620: 1 630:1, 640:1, 650:1, 660:1, 670:1, 6
  • composition of the present invention is effective for controlling the true and bacterial diseases of crops, and more importantly, the combination of the two can better regulate the growth of crops, promote the health effects of crops, and improve crops. Production.
  • the present invention provides the use of a pesticidal composition
  • a pesticidal composition comprising component A (one of the thiocarbamates) and component B for controlling crop diseases or promoting plant growth in the agricultural field, particularly in rice, corn or The use of fruit trees to regulate crop growth and improve disease resistance.
  • composition of the present invention can also be used in combination with other pesticides (such as fungicides, insecticides, herbicides, plant growth regulators), fertilizers, etc., and these are mixed with Commonly used pesticides or fertilizers disclosed in the art.
  • pesticides such as fungicides, insecticides, herbicides, plant growth regulators
  • fertilizers etc.
  • composition of the present invention can be made into a pesticide-acceptable dosage form from the active ingredient and the pesticide adjuvant. Further, the composition comprises 15.0001 to 90.9999% by weight of the active ingredient and 84.9999 to 9.001% by weight of the pesticide adjuvant to constitute a pesticide-acceptable dosage form.
  • the above composition may specifically comprise an agrochemical auxiliary, such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, a fertilizer, etc., during the application process.
  • an agrochemical auxiliary such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, a fertilizer, etc.
  • Common additives can be mixed in.
  • Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers. .
  • the method of application of the compositions of the invention comprises the use of the compositions of the invention for aerial parts of plants, in particular leaves or foliage. You can choose to soak or apply to the surface of the control object.
  • the frequency of administration and the amount administered will depend on the biological and climatic conditions of the pathogen.
  • the plant growth site such as rice fields, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant. In vivo (systemic action).
  • compositions may be applied only with the active ingredient or may be mixed with an additive (agrochemical adjuvant).
  • composition of the present invention can be prepared into a pesticide-acceptable dosage form such as a wettable powder, a suspension, a water-dispersible granule, an aqueous emulsion or a microemulsion, an emulsifiable concentrate, a dispersible oil suspension, a suspoemulsion, an oil suspension or a micro Capsule type and the like.
  • a pesticide-acceptable dosage form such as a wettable powder, a suspension, a water-dispersible granule, an aqueous emulsion or a microemulsion, an emulsifiable concentrate, a dispersible oil suspension, a suspoemulsion, an oil suspension or a micro Capsule type and the like.
  • a pesticide-acceptable dosage form such as a wettable powder, a suspension, a water-dispersible granule, an aqueous emulsion or a microemulsion, an emul
  • composition of the present invention can be prepared into various dosage forms by known methods, and the active ingredient and auxiliary agent can be used, for example.
  • the solvent and the solid carrier can be uniformly mixed and ground with a surfactant as needed to prepare a desired dosage form.
  • the above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • aromatic hydrocarbons preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • Hexane or paraffin alcohol and ethylene glycol and their ethers and esters, such as ethanol, ethylene glycol, ethylene glycol monomethyl; ketones, such as cyclohexanone, highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide, and vegetable or vegetable oils such as soybean oil.
  • the above solid carriers are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay.
  • a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand.
  • a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
  • Suitable surfactants are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene poly
  • the two active ingredients in the compositions of the present invention exhibit synergistic effects, the activity of which is more pronounced than the expected sum of activity using a single compound, and the individual activity of a single compound.
  • the synergistic effect is manifested by allowing for a reduced application rate, a broader fungicidal control profile, quicker effect, longer lasting control effect, better control of plant harmful fungi by only one or a few applications, and broadening of possible application. Intervals. These properties are particularly desirable in the practice of plant fungi control.
  • the other characteristics exhibited by the pesticidal composition of the present invention are mainly as follows: 1.
  • the compounding of the composition of the present invention has obvious synergistic effect; 2. Since the chemical composition of the two single agents of the present composition is greatly different, the effect The mechanism is completely different, there is no cross-resistance, which can delay the resistance problem caused by the two single agents alone; 3.
  • the composition of the invention can well regulate crop growth, improve disease resistance and stress resistance, and promote crop health effects. To increase crop yields.
  • the active ingredient A and the active ingredient B are sufficiently mixed with various auxiliary agents and fillers, and are pulverized by an ultrafine pulverizer to obtain a wettable powder.
  • Active component A (mancozeb) and thidiam to prepare wettable powder
  • Example 1 45.09% mancozeb thiazolone wettable powder
  • Example 2 60.024% mancozeb-thiablon wettable powder
  • Example 3 70.02% mancozeb thiazolone wettable powder
  • Example 4 90.02% mancozeb and thidiam WP
  • Active component A (Dyson) and thidiam to prepare wettable powder
  • Dyson was 45%, thiabendazole was 0.09%, and the remaining components were prepared in accordance with the method of Example 1.
  • Daisen was 60%, thiabendazole was 0.024%, and the remaining components were prepared according to the method of Example 2.
  • Daisen was 70%, thiabendazole was 0.02%, and the remaining components were prepared in accordance with the method of Example 3.
  • Desensen was 90%, thiabendazole was 0.02%, and the remaining components were prepared in accordance with the method of Example 4.
  • Active component A (benzinc zinc) and thidiazuron to prepare wettable powder
  • Example 9 45.09% propenyl zinc thiabendazole wettable powder
  • the zinc bromide was 45%, the thiabendazole was 0.09%, and the remaining components were prepared in accordance with the method of Example 1.
  • Example 10 60.024% propenyl zinc thiabendazole wettable powder
  • the zinc bromide was 60% and the thiabendazole was 0.024%.
  • the remaining components were prepared according to the method of Example 2.
  • Example 11 70.02% propenyl zinc thiabendazole wettable powder
  • Propylene zinc was 70%, thiabendazole was 0.02%, and the remaining components were prepared in accordance with the method of Example 3.
  • Example 12 90.02% propenyl zinc thiabendazole wettable powder
  • the zinc bromide was 90% and the thiabendazole was 0.02%, and the remaining components were prepared in the same manner as in Example 4.
  • the active ingredient A and the active ingredient B, and the components such as a dispersing agent, a wetting agent, a thickener and water are uniformly mixed according to the formulation, and after being sanded and/or sheared at a high speed, a semi-finished product is obtained. After the analysis, the water is added and uniformly filtered to obtain the finished product.
  • Active component A (mancozeb) and thiabendazole to prepare suspension
  • Example 13 10.125% mancozeb and thiabendazole suspension
  • Example 14 25.0167% mancozeb and thiabendazole suspension
  • Example 15 40.01% mancozeb and thiabendazole suspension
  • the rubber is 2.38%, the silicone oil is 0.02%, and the water is made up to 100%.
  • Daisen was 10%, thiabendazole was 0.125%, and the remaining components were prepared according to the method of Example 13.
  • Daisen was 25%, thiabendazole was 0.0167%, and the remaining components were prepared according to the method of Example 14.
  • Daisen was 40%, thiabendazole was 0.01%, and the remaining components were prepared according to the method of Example 15.
  • Active component A (benzinc zinc) and thidiazuron preparation suspension
  • Example 21 10.125% propenyl zinc thiabendazole suspension
  • the zinc was 10%, the thidiazepine was 0.125%, and the remaining components were prepared in accordance with the procedure of Example 13.
  • Example 22 25.0167% propenyl zinc thiabendazole suspension
  • the zinc was 25%, the thiabendazole was 0.0167%, and the remaining components were prepared according to the method of Example 14.
  • Example 23 40.01% propenyl zinc thiabendazole suspension
  • the zinc was 40%, the thidiam was 0.01%, and the remaining components were prepared according to the method of Example 15.
  • Example 24 55.011% propenyl zinc thiabendazole suspension
  • the zinc was 55%, the thidiam was 0.011%, and the remaining components were prepared according to the method of Example 16.
  • the active ingredient A and the active ingredient B, and the auxiliary agent and the filler are uniformly mixed according to the formula, and are pulverized into a wettable powder by a jet stream, and then added with a certain amount of water to be mixed and squeezed, and sieved to obtain water dispersion. Granule products.
  • Active component A mancozeb
  • thidiazuron to prepare water-dispersible granules
  • Example 25 20.02% mancozeb and thiaphenone water dispersible granules
  • Example 26 65.0325% Mancozeb and Thiablon Water Dispersible Granules
  • Example 27 85.0283% mancozeb and thiablon water dispersible granules
  • Active component A (Dyson) and thidiazuron to prepare water-dispersible granules
  • Example 28 20.02% Daisenlian ⁇ Thiabendron Water Dispersible Granules
  • Daisen was 20%, thiabendazole was 0.02%, and the remaining components were prepared in accordance with the procedure of Example 25.
  • Desensen was 65%, thiabendazole was 0.0325%, and the remaining components were prepared in accordance with the method of Example 26.
  • Example 30 85.0283% Daisenlian ⁇ thiaphenon water dispersible granules
  • Daisen was 85%, thiabendazole was 0.0283%, and the remaining components were prepared according to the method of Example 27.
  • Active component A (benzinc zinc) and thidiazuron to prepare water-dispersible granules
  • Example 31 20.02% propargyl zinc thiabendazole water dispersible granules
  • the zinc bromide was 20% and the thiabendazole was 0.02%, and the remaining components were prepared in accordance with the procedure of Example 25.
  • Example 32 65.0325% propenyl zinc thiabendazole water dispersible granules
  • the zinc bromide was 65%, the thiabendazole was 0.0325%, and the remaining components were prepared in accordance with the procedure of Example 26.
  • Example 33 85.0283% propenzine zinc thiabendazole water dispersible granules
  • the zinc bromide was 85%, the thiabendazole was 0.0283%, and the remaining components were prepared in accordance with the procedure of Example 27.
  • Mancozeb and thiablon were diluted with acetone at a certain concentration, and the crops were sprayed with stems and leaves.
  • the effects of various concentrations on crop growth were determined in the field, including plant height, plant diameter, disease resistance and fruit quality. , as well as the production situation, etc. for comprehensive evaluation.
  • Plant height control rate (clear water control plant height - treated plant height) / clear water control plant height * 100%
  • stem diameter (plant stem diameter after treatment - stem diameter of clear water control plants) / stem diameter of clear water control plants * 100%
  • Grain 1000-grain weight increase rate (1000-grain weight of treated grain - 1000-grain weight of grain of clear water control) / Grain 1000-grain weight of clear water control *100%
  • mancozeb has obvious effects on the growth regulation of corn under different ratios, mainly in: 1. It can effectively regulate the control of corn, that is, reduce the plant height and ear position of corn, effectively balance the relationship between vegetative growth and reproductive growth, and prevent lodging; 2. It can effectively increase the diameter of corn and improve the nutrient transfer capacity of plants. Moreover, by promoting the plant diameter, the lodging resistance of corn can be improved; 3. Mancozeb has a good systemic conduction effect, and has a good preventive effect on corn leaf spot, and thiabendone belongs to plant internal growth hormone. It can enhance the disease resistance and resilience of crops.
  • mancozeb and thiabendazole have a good synergistic effect, and the preventive effect on corn leaf blight has a good preventive effect compared with single agent and clear water control; Because of the synergistic effect of mancozeb and thiabendazole in the early stage of corn growth, it promotes the nutrient conduction, disease resistance and resistance of corn plants. At the maturity stage of corn, the 1000-grain weight of corn And the unit of production has a significant improvement The utilization rate of per mu is up to 16.2%.
  • Dyson and thidiam were diluted with acetone at a certain concentration, sprayed during the flowering stage of wheat, and the effects of each ratio on crop growth were determined in the field, including plant height, ear length, disease resistance, and fruit weight. And comprehensive evaluation of the yield per mu.
  • Plant height control rate (clear water control plant height - treated plant height) / clear water control plant height * 100%
  • Ear length increase rate (plant ear length after treatment - clear water control plant ear length) / clear water control plant ear length * 100%
  • Grain 1000-grain weight increase rate (1000-grain weight of treated grain - 1000-grain weight of grain of clear water control) / Grain 1000-grain weight of clear water control *100%
  • the combination of Daisenlian and Thiabendron has obvious effects on the growth regulation of wheat under different ratios, mainly in wheat.
  • the application of poplar stage can effectively regulate the healthy growth of wheat. 1. It can dwarf wheat plants, effectively control the length of wheat control and prevent wheat from lodging; 2. It can increase the ear length of wheat and increase the number of grains per ear; 3. It can significantly increase the weight of wheat grains; 4. Daisenlian on wheat It has good systemic absorption and has certain protective effect on wheat growth prevention of fungal diseases. Thiabendazole has certain resistance to disease and stress, and it has certain synergistic effect after mixing. The composition of the present invention has a significant effect on the unit yield of wheat.
  • the zinc and thidiazepines were diluted with acetone at a certain concentration, and the crops were sprayed with stems and leaves.
  • the effects of various concentrations on the growth of the crops were measured in the field, including the plant height, stem diameter, fruit diameter, disease resistance, and A single evaluation of the individual fruit weight and yield.
  • Plant height control rate (clear water control plant height - treated plant height) / clear water control plant height * 100%
  • Stem diameter increase rate (stem diameter after treatment - clear water control stem diameter) / clear water control stem diameter * 100%
  • Fruit diameter increase rate (fruit diameter after treatment - clear water control fruit diameter) / clear water control fruit diameter * 100%
  • Single fruit weight increase rate (single fruit weight after treatment - clear water control single fruit weight) / water control single fruit weight * 100%
  • the tomato plant can be dwarfed, the tomato can be controlled to control the length of the tomato, the tomato stems can be thickened, and the lodging resistance of the tomato can be increased.
  • the weight of the single tomato can be increased and the quality of the fruit can be increased;
  • Zinc has a certain systemic effect on tomato, and has certain protective effects on fungal diseases such as tomato, while thiabendazole has certain resistance to disease and stress, and it has significant synergistic effect after mixing.
  • the composition of the present invention has a significant effect on the unit yield of tomato.
  • Application period rice at the end of the Qisui period.
  • the number of panicles in rice (the number of grains per panicle was more than 5 grains per serving), the total number of grains per panicle, the number of grains per panicle, the seed setting rate, and the yield per mu were calculated. The yield was calculated and statistical analysis was performed.
  • test results show that the application of the preparation product of the invention at the end of rice seeding can effectively regulate the healthy growth of rice.
  • Dwarf rice plants effectively control the rice control and prevent rice from lodging; 2. It can increase the number of panicles in rice and increase the seed setting rate of rice; 4.
  • Mancozeb has certain systemicity to rice. It has a certain protective effect on fungal diseases such as rice sheath blight, and thidiazepine has certain resistance to disease and stress, and it has significant synergistic effect after mixing; 5.
  • Composition of the present invention Significant improvement in the unit yield of rice
  • Application period two sprays were carried out after apple flowering and apple fruit setting.
  • Table 5 shows the field comprehensive experiment of apple growth regulation by the combination of Senlian and Thiabendron
  • Application period two sprays were carried out 10 days before flowering and 12 days after flowering.

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  • Pest Control & Pesticides (AREA)
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Abstract

本发明公开了一种包含硫代氨基甲酸酯类化合物和噻苯隆的农药组合物，其有效成分包含A和B，其中活性组分A为硫代氨基甲酸酯类化合物，活性组分B为噻苯隆，两组分之间的重量比为(80～5000)∶1，本发明还提供了该组合物的制备方法及用途。试验结果表明，本发明的组合物可很好的调节作物生长，提高抗病抗逆性，促进作物健康作用，提高作物产量。

Description

一种包含硫代氨基甲酸酯类化合物和噻苯隆的农药组合物 技术领域
本发明属于农业植物保护领域，特别是涉及一种具有改进性能的农药组合物，具体地说是涉及一种包含硫代氨基甲酸酯类化合物和噻苯隆农药的组合物。
背景技术
代森锰锌(mancozeb)是一种高效、低毒、低残留、杀菌谱广的保护性杀菌剂，主要用于防治麦类、水果、蔬菜等多种真菌病害。其杀菌作用机理，使用后可在叶片、果实的表面形成一层透气、透水、透光的致密保护膜，抑制病菌孢子的萌发和入侵，破坏病菌正常生理代谢所需各种酶的活性，从而达到杀菌防病的目的。
代森联(metiram)是一种优良的保护性杀菌剂，属低毒农药。由于其杀菌范围广、不易产生抗性，防治效果明显优于其他同类杀菌剂，所以在国际上用量一直是大吨位产品。是目前其他保护性杀菌剂的替代产品，国内多数复配杀菌剂都以代森锰锌加工配制而成，但锰锌制剂会引起作物微量元素积累中毒，通过近几年田间应用，对防治梨黑星病、苹果斑点落叶病、瓜菜类疫病、霜霉病、大田作物锈病等效果显著，不用其他任何杀菌剂完全可有效控制病害发生，质量稳定、可靠。
丙森锌(propineb)是一种广谱、速效的保护性杀菌剂。适用于番茄、白菜、黄瓜、芒果和花卉等作物。防治白菜霜霉病、黄瓜霜霉病、番茄早晚疫病、芒果炭疽病。丙森锌是一种速效、残效期长、广谱的保护性杀菌剂，对蔬菜、烟草、啤酒花等作物的霜霉病以及番茄和马铃薯的早、晚疫病均有良好的保护作用，并且对白粉病、锈病和葡萄孢属病菌引起的病害也有一定的抑制作用。在推荐剂量下对作物安全。
噻苯隆(pyraclostrobin)是新型高效植物生长调节剂，噻苯隆被植物吸收后，可促进叶柄与茎之间的分离组织，形成自然脱落，在农药、肥料中可被广泛应用。它具有极强的生物活性，其诱导植物细胞分裂、愈伤组织形成的能力比一般细胞分裂素高许多倍。提高作物吸收能力，增加光合作用，从而达到增产、增优目的。可用于各类瓜、果、蔬菜、苗木、花卉、粮食、烟草等作物，还可用于组织培养、基因工程等。在生产上能显著提高 作物产量、改善品质且有用量少、对生态环境无污染，对人、畜、鸟、蜜蜂、天敌无毒等特点。
实际的农药经验已经表明，重复且专一施用一种活性化合物来防治有害菌种在很多情况下将导致菌种菌株的快速选择性，为降低抗性菌种菌株选择性的危险性，目前通常使用不同活性化合物的混合物来防治有害菌种。通过将具有不同作用机理的活性化合物进行组合，可延缓抗性产生，降低施用量，减少防治成本。
发明内容
本发明的目的是提供一种具有增效作用的农药组合物，以提高杀菌防治效果，延缓抗性产生，同时能够调剂作物生长，提高作物产量。
本发明的另一个目的是提供包含两种有效成分A和B杀菌组合物的制备方法及在农业领域防病抗病或促进植物生长中的应用。
本发明的目的可以通过以下措施达到：
一种农药组合物，所述的组合物包含A和B两种活性组分，其中活性组分A为硫代氨基甲酸酯类化合物中，选自代森锰锌、代森联和丙森锌中的任意一种化合物，其中活性组分B为噻苯隆。
两组分之间的重量比为(80～5000)∶1，为使本发明的组合物效果进一步提升，两组分之间的重量比优化为(200～4500)∶1，进一步优选(500～4500)∶1。
一种优选的方案中，A和B两组分之间的重量比可以任意地在下述配比的范围内进行调整：80∶1、90∶1、100∶1、110∶1、120∶1、130∶1、140∶1、150∶1、160∶1、170∶1、180∶1、190∶1、200∶1、210∶1、220∶1、230∶1、240∶1、250∶1、260∶1、270∶1、280∶1、290∶1、300∶1、310∶1、320∶1、330∶1、340∶1、350∶1、360∶1、370∶1、380∶1、390∶1、400∶1、410∶1、420∶1、430∶1、440∶1、450∶1、460∶1、470∶1、480∶1、490∶1、500∶1、510∶1、520∶1、530∶1、540∶1、550∶1、560∶1、570∶1、580∶1、590∶1、600∶1、610∶1、620∶1、630∶1、640∶1、650∶1、660∶1、670∶1、680∶1、690∶1、700∶1、710∶1、720∶1、730∶1、740∶1、750∶1、760∶1、770∶1、780∶1、790∶1、800∶1、810∶1、820∶1、830∶1、840∶1、850∶1、860∶1、870∶1、880∶1、890∶1、900∶1、910∶1、920∶1、930∶1、940∶1、950∶1、960∶1、970∶1、980∶1、990∶1、1000∶1、1100∶1、1200∶1、1300∶1、1400∶1、1500∶1、1600∶1、1700∶1、1800∶1、1900、2000∶1、2100∶1、2200∶1、2300∶1、2400∶1、2500∶1、2600∶1、2700∶1、2800∶1、2900∶1、3000∶1、3100∶1、3200∶1、3300∶1、3400∶1、3500∶1、3600∶1、3700∶1、3800∶1、3900∶1、4000∶1、4100∶1、4200∶1、4300∶1、4400∶1、4500∶1、 4600∶1、4700∶1、4800∶1、4900∶1、5000∶1，也可以在以上任意两个配比所组成的范围内进行选择，这些比例可以理解为重量比，也可以包括摩尔比。
发明人通过试验发现，本发明的组合物是用于防治农作物真、细菌性病害增效明显，更重要的是两者复配可以更好的调节作物的生长，促进作物的健康作用，提高作物的产量。
本发明提供了包含组分A(硫代氨基甲酸酯类中的一种)和组分B的农药组合物在农业领域防治农作物病害或促进植物生长中方面的用途，特别是在水稻、玉米或果树中调节作物生长提高抗病效果等方面的用途。
为充分发挥本发明的优势效果，本发明的组合物还可以与其他农药(如杀菌剂、杀虫剂、除草剂、植物生长调节剂)、肥料等混合使用，这些与之混用的均为现有技术公开的常用的农药或肥料。
本发明的组合物可以由活性成分和农药助剂制成农药上允许的剂型。进一步的，该组合物由15.0001～90.9999％重量份的活性组分与84.9999～9.0001％重量份的农药助剂组成农药上允许的剂型。
上述组合物具体可包含农药助剂，例如载体、溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂、肥料等中的一种或几种，在施用的过程中可以混合常用的助剂。
合适的助剂可以是固体或液体，它们通常是剂型加工过程中常用的物质，例如天然的或再生的矿物质，溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂或肥料。
本发明组合物的施用方法包括将本发明的组合物用于植物生长的地上部分，特别是叶部或叶面。可以选择浸种或涂抹于防治对象表面。施用的频率和施用量取决于病原体的生物学和气候生存条件。可以将植物的生长场所，如稻田，用组合物的液体制剂浸湿，或者将组合物以固体形式施用于土壤中，如以颗粒形式(土壤施用)，组合物可以由土壤经植物根部进入植物体内(内吸作用)。
这些组合物可以仅仅包含活性成分进行施用，也可以与添加剂(农药助剂)一起混合使用。
本发明的组合物可以制备成农药上可接受的剂型，例如可湿性粉剂、悬浮剂、水分散粒剂、水乳剂或微乳剂、乳油、可分散油悬浮剂、悬乳剂、油悬浮剂或微囊剂型等。根据这些组合物的性质以及施用组合物所要达到的目的和环境情况，可以选择将组合物以喷雾、弥雾、喷粉、撒播或泼浇等之类的方法施用。
可用已知的方法可以将本发明的组合物制备成各种剂型，可以将有效成分与助剂，如 溶剂、固体载体，需要时可以与表面活性剂一起均匀混合、研磨，制备成所需要的剂型。
上述的溶剂可选自芳香烃，优选含8-12个碳原子，如二甲苯混合物或取代的苯，酞酸酯类，如酞酸二丁酯或酞酸二辛酸，脂肪烃类，如环己烷或石蜡，醇和乙二醇和它们的醚和酯，如乙醇，乙二醇，乙二醇单甲基；酮类，如环己酮，强极性的溶剂，如N-甲基-2-吡咯烷酮，二甲基亚砜或二甲基甲酰胺，和植物油或植物油，如大豆油。
上述的固体载体，如用于可湿性粉剂和可分散剂的通常是天然矿物填料，例如滑石、高岭土，蒙脱石或活性白土。为了管理组合物的物理性能，也可以加入高分散性硅酸或高分散性吸附聚合物载体，例如粒状吸附载体或非吸附载体，合适的粒状吸附载体是多孔型的，如浮石、皂土或膨润土；合适的非吸附载体如方解石或砂。另外，可以使用大量的无机性质或有机性质的预制成粒状的材料作为载体，特别是白云石。
根据本发明的组合物中的有效成分的化学性质，合适的表面活性剂为木质素磺酸、萘磺酸、苯酚磺酸、碱土金属盐或胺盐，烷基芳基磺酸盐，烷基硫酸盐，烷基磺酸盐，脂肪醇硫酸盐，脂肪酸和硫酸化脂肪醇乙二醇醚，还有磺化萘和萘衍生物与甲醛的缩合物，萘或萘磺酸与苯酚和甲醛的缩合物，聚氧乙烯辛基苯基醚，乙氧基化异辛基酚，辛基酚，壬基酚，烷基芳基聚乙二醇醚，三丁基苯聚乙二醇醚，三硬脂基苯基聚乙二醇醚，烷基芳基聚醚醇，乙氧基化蓖麻油，聚氧乙烯烷基醚，氧化乙烯缩合物、乙氧基化聚氧丙烯，月桂酸聚乙二醇醚缩醛，山梨醇酯，木质素亚硫酸盐废液和甲基纤维素。
本发明的组合物中两种有效成分表现为增效效果，该组合物的活性比使用单个化合物的活性预期总和，以及单个化合物的单独活性更为显著。增效效果表现为允许施用量减少、更宽的杀真菌控制谱、见效快、更持久的防治效果、通过仅仅一次或少数几次施用更好的控制植物有害真菌、以及加宽了可能的施用间隔时间。这些特性是植物真菌控制实践过程中特别需要的。
本发明的农药组合物的表现出的其它特点主要表现为：1、本发明的组合物混配具有明显的增效作用；2、由于本组合物的两个单剂化学结构差异很大，作用机理完全不同，不存在交互抗性，可延缓两单剂单独使用所产生的抗性问题；3、本发明的组合物可很好的调节作物生长，提高抗病抗逆性，促进作物健康作用，提高作物产量。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅用以解释本发明，并不用于限 定本发明，凡在本发明的精神和原则之内所做的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。
以下实施例所有配方中百分比均为重量百分比。本发明组合物各种制剂的加工工艺均为现有技术，根据不同情况可以有所变化。
一、剂型制备实施例
(一)可湿性粉剂的加工及实施例
将活性成分A与活性成分B与各种助剂及填料等按比例充分混合，经超细粉碎机粉碎后制得可湿性粉剂。
1、活性组分A(代森锰锌)和噻苯隆制备可湿性粉剂
实施例1：45.09％代森锰锌·噻苯隆可湿性粉剂
代森锰锌45％，噻苯隆0.09％，木质素磺酸钠盐10.63％，膨润土5.22％，十二烷基苯磺酸钙7.34％，凹凸棒土补足至100％。
实施例2：60.024％代森锰锌·噻苯隆可湿性粉剂
代森锰锌60％，噻苯隆0.024％，纤维素衍生物6.35％，十二烷基硫酸钠8.04％，尿素4.06％，凹凸棒土补足至100％。
实施例3：70.02％代森锰锌·噻苯隆可湿性粉剂
代森锰锌70％，噻苯隆0.02％，脂肪酸聚乙二醇酯3.57％，硫酸铵4.25％，烷基酚聚氧乙烯醚硫酸盐7.42％，高岭土补足至100％。
实施例4：90.02％代森锰锌·噻苯隆可湿性粉剂
代森锰锌90％，噻苯隆0.02％，十二烷基硫酸钠2.54％，皂角粉3.53％，碳酸氢钠3.32％，白炭黑补足至100％。
2、活性组分A(代森联)和噻苯隆制备可湿性粉剂
实施例5：45.09％代森联·噻苯隆可湿性粉剂
代森联45％，噻苯隆0.09％，其余组分按照实施例1的方法制备。
实施例6：60.024％代森联·噻苯隆可湿性粉剂
代森联60％，噻苯隆0.024％，其余组分按照实施例2的方法制备。
实施例7：70.02％代森联·噻苯隆可湿性粉剂
代森联70％，噻苯隆0.02％，其余组分按照实施例3的方法制备。
实施例8：90.02％代森联·噻苯隆可湿性粉剂
代森联90％，噻苯隆0.02％，其余组分按照实施例4的方法制备。
3、活性组分A(丙森锌)和噻苯隆制备可湿性粉剂
实施例9：45.09％丙森锌·噻苯隆可湿性粉剂
丙森锌45％，噻苯隆0.09％，其余组分按照实施例1的方法制备。
实施例10：60.024％丙森锌·噻苯隆可湿性粉剂
丙森锌60％，噻苯隆0.024％，其余组分按照实施例2的方法制备。
实施例11：70.02％丙森锌·噻苯隆可湿性粉剂
丙森锌70％，噻苯隆0.02％，其余组分按照实施例3的方法制备。
实施例12：90.02％丙森锌·噻苯隆可湿性粉剂
丙森锌90％，噻苯隆0.02％，其余组分按照实施例4的方法制备。
(二)悬浮剂的加工及实施例
将活性成分活性组分A与活性组分B，与分散剂、润湿剂、增稠剂和水等各组分按配方的比例混合均匀，经砂磨和/或高速剪切后，得到半成品，分析后补加水混合均匀过滤即得成品。
1、活性组分A(代森锰锌)和噻苯隆制备悬浮剂
实施例13：10.125％代森锰锌·噻苯隆悬浮剂
代森锰锌10％，噻苯隆0.125％，十二烷基硫酸钠呀盐10.58％，苯磺酸钠8.12％，硅酸镁铝3.21％，膨润土5.57％，丙三醇8％，硅油0.01％，水补足至100％。
实施例14：25.0167％代森锰锌·噻苯隆悬浮剂
代森锰锌25％，噻苯隆0.0167％，木质素磺酸钠盐15.37％，拉开粉BX 9.56％，硫酸铵5.37％，乙二醇10％，硅酸镁铝4.72％，硅油0.01％，水补足至100％。
实施例15：40.01％代森锰锌·噻苯隆悬浮剂
代森锰锌40％，噻苯隆0.01％，烷基酚聚氧乙烯醚10.42％，聚氧乙烯聚氧丙烯嵌段共聚物9.84％，碳酸氢钠3.21％，丙三醇15％，黄原胶2.38％，硅油0.02％，水补足至100％。
实施例16：55.011％代森锰锌·噻苯隆悬浮剂
代森锰锌55％，噻苯隆0.011％，三聚磷酸钠12.54％，十二烷基硫酸钠10.58％，膨润土4.21％，硅酸镁铝3.22％，乙二醇10％，硅油0.01％，水补足至100％。
2、活性组分A(代森联)和噻苯隆制备悬浮剂
实施例17：10.125％代森联·噻苯隆悬浮剂
代森联10％，噻苯隆0.125％，其余组分按照实施例13的方法制备。
实施例18：25.0167％代森联·噻苯隆悬浮剂
代森联25％，噻苯隆0.0167％，其余组分按照实施例14的方法制备。
实施例19：40.01％代森联·噻苯隆悬浮剂
代森联40％，噻苯隆0.01％，其余组分按照实施例15的方法制备。
实施例20：55.011％代森联·噻苯隆悬浮剂
代森联55％，噻苯隆0.011％，其余组分按照实施例16的方法制备。
3、活性组分A(丙森锌)和噻苯隆制备悬浮剂
实施例21：10.125％丙森锌·噻苯隆悬浮剂
丙森锌10％，噻苯隆0.125％，其余组分按照实施例13的方法制备。
实施例22：25.0167％丙森锌·噻苯隆悬浮剂
丙森锌25％，噻苯隆0.0167％，其余组分按照实施例14的方法制备。
实施例23：40.01％丙森锌·噻苯隆悬浮剂
丙森锌40％，噻苯隆0.01％，其余组分按照实施例15的方法制备。
实施例24：55.011％丙森锌·噻苯隆悬浮剂
丙森锌55％，噻苯隆0.011％，其余组分按照实施例16的方法制备。
(三)水分散粒剂的加工及实施例
将活性成分A与活性成分B，与助剂和填料按配方的比例混合均匀，经气流粉碎成可湿性粉剂，再加入一定量的水混合挤压造粒，经干燥筛分后制得水分散粒剂产品。
1、活性组分A(代森锰锌)和噻苯隆制备水分散粒剂
实施例25：20.02％代森锰锌·噻苯隆水分散粒剂
代森锰锌20％，噻苯隆0.02％，萘磺酸钠盐15.84％，木质素磺酸钠盐14.12％，硅藻土11.32％，黄原胶4.99％，高岭土补足至100％。
实施例26：65.0325％代森锰锌·噻苯隆水分散粒剂
代森锰锌65％，噻苯隆0.0325％，木质素苯磺酸钠盐15.39％，十二烷基苯磺酸钙8.43％，硫酸铵5％，硅酸镁铝1.27％，白炭黑补足至100％。
实施例27：85.0283％代森锰锌·噻苯隆水分散粒剂
代森锰锌85％，噻苯隆0.0283％，脂肪醇聚氧乙烯醚3.45％，皂角粉3.32％，硫酸铵4.32％，硅酸镁铝0.86％，白炭黑补足至100％。
2、活性组分A(代森联)和噻苯隆制备水分散粒剂
实施例28：20.02％代森联·噻苯隆水分散粒剂
代森联20％，噻苯隆0.02％，其余组分按照实施例25的方法制备。
实施例29：65.0325％代森联·噻苯隆水分散粒剂
代森联65％，噻苯隆0.0325％，其余组分按照实施例26的方法制备。
实施例30：85.0283％代森联·噻苯隆水分散粒剂
代森联85％，噻苯隆0.0283％，其余组分按照实施例27的方法制备。
3、活性组分A(丙森锌)和噻苯隆制备水分散粒剂
实施例31：20.02％丙森锌·噻苯隆水分散粒剂
丙森锌20％，噻苯隆0.02％，其余组分按照实施例25的方法制备。
实施例32：65.0325％丙森锌·噻苯隆水分散粒剂
丙森锌65％，噻苯隆0.0325％，其余组分按照实施例26的方法制备。
实施例33：85.0283％丙森锌·噻苯隆水分散粒剂
丙森锌85％，噻苯隆0.0283％，其余组分按照实施例27的方法制备。
二、药效验证试验
(一)生物测定实施例
1、代森锰锌与噻苯隆复配对玉米生长调节综合测定试验
将代森锰锌与噻苯隆用丙酮按照一定浓度稀释，对作物进行茎叶喷雾，在田间测定各个浓度对作物生长的影响，包括对作物的株高、株径、抗病情况、果实品质，以及产量情况等进行综合评价。
株高控制率＝(清水对照株高-处理后的株高)/清水对照株高*100％
茎径提高率＝(处理后的植株茎径-清水对照植株茎径)/清水对照植株茎径*100％
预防效果＝(清水对照的发病指数-处理后的发病指数)/清水对照的发病指数*100％
籽粒千粒重提高率＝(处理后的籽粒千粒重-清水对照的籽粒千粒重)/清水对照的籽粒千粒重*100％
亩产提高率＝(处理后的亩产量-清水对照的亩产量)/清水对照的亩产量*100％
表1.代森锰锌与噻苯隆复配对玉米生长调节综合测定汇总表
Figure PCTCN2017114516-appb-000001
Figure PCTCN2017114516-appb-000002
注：表1中“代”为“代森锰锌”，“噻”为“噻苯隆”缩写。施药时期：大喇叭口初期，该阶段玉米植株未发生玉米小斑病。施药次数：2次，施药间隔期7天；施药方式：茎叶喷雾；调查时期：玉米抽雄初期；本试验中，株高、茎径、发病指数、籽粒千粒重等指标均为各处理的平均值。
通过实验发明人发现，代森锰锌与噻苯隆之间具有很好协同提升作用，代森锰锌与噻苯隆混配在不同配比下，对玉米的生长调节作用明显，主要表现在：1、可有效调节玉米的控旺徒长，即降低玉米株高和穗位，有效平衡营养生长与生殖生长的关系，防止倒伏；2、可有效增加玉米的株径，提升植株上下营养传导能力，而且通过促进株径，可以提高玉米的抗倒伏性能；3、代森锰锌具有很好内吸传导作用，对玉米小斑病具有很好的预防作用，而噻苯隆属于植物内在生长激素，可以增强作物的抗病抗逆能力，代森锰锌与噻苯隆之间共同施用具有良好的协同作用，对玉米小斑病的预防效果相对于单剂及清水对照，具有很好预防效果；4、由于玉米生长前期代森锰锌与噻苯隆的协同作用，促进了玉米植株的营养传导、抗病抗逆，在玉米成熟期，对玉米的千粒重以及单位亩产有显著的提升作 用，亩产提高率最高达到16.2％。
2、代森联与噻苯隆复配对小麦生长调节综合测定试验
将代森联与噻苯隆用丙酮按照一定浓度稀释，在小麦扬花期进行喷雾，在田间测定各个配比对作物生长的影响，包括对株高、穗长、抗病情况、果实粒重，以及亩产量情况等进行综合评价。
株高控制率＝(清水对照株高-处理后的株高)/清水对照株高*100％
穗长提高率＝(处理后的植株穗长-清水对照植株穗长)/清水对照植株穗长*100％
预防效果＝(清水对照的发病指数-处理后的发病指数)/清水对照的发病指数*100％
籽粒千粒重提高率＝(处理后的籽粒千粒重-清水对照的籽粒千粒重)/清水对照的籽粒千粒重*100％
亩产提高率＝(处理后的亩产量-清水对照的亩产量)/清水对照的亩产量*100％
表2代森联与噻苯隆复配对小麦生长调节综合测定汇总表
Figure PCTCN2017114516-appb-000003
Figure PCTCN2017114516-appb-000004
注：表2中“代”为“代森联”，“噻”为“噻苯隆”缩写。施药时期：小麦扬花初期，小麦中后期正是赤霉病等病害发病时期。施药次数：1次。调查时期：小麦成熟期；本试验中，株高、穗长、发病指数、籽粒千粒重等指标均为各处理的平均值。
通过实验发明人发现，代森联与噻苯隆之间具有很好协同提升作用，代森联与噻苯隆混配在不同配比下，对小麦的生长调节作用明显，主要表现在：在小麦杨花期施用，可以有效调节小麦的健康生长。1、可以矮化小麦植株，有效控制小麦控旺徒长，防止小麦倒伏；2、可以提升小麦的穗长，提高穗粒数；3、可显著提高小麦籽粒的重量；4、代森联对小麦具有较好的内吸性，对小麦生长预防真菌病害具有一定的保护作用，而噻苯隆对小麦生长具有一定的抗病抗逆能力，两者混配后具有一定的协同增效作用；5、本发明的组合物对小麦的单位产量具有显著的提升作用。
3、丙森锌与噻苯隆复配对番茄生长调节综合测定试验
将丙森锌与噻苯隆用丙酮按照一定浓度稀释，对作物进行茎叶喷雾，在田间测定各个浓度对作物生长的影响，包括对作物的株高、茎径、果径、抗病情况、单颗果重以及产量情况等进行综合评价。
株高控制率＝(清水对照株高-处理后的株高)/清水对照株高*100％
茎径提高率＝(处理后的茎径-清水对照茎径)/清水对照茎径*100％
果径提高率＝(处理后的果径-清水对照果径)/清水对照果径*100％
预防效果＝(清水对照的发病指数-处理后的发病指数)/清水对照的发病指数*100％
单颗果重提高率＝(处理后的单颗果重-清水对照单颗果重)/清水对照单颗果重*100％
亩产提高率＝(处理后的亩产量-清水对照的亩产量)/清水对照的亩产量*100％
表3丙森锌与噻苯隆复配对番茄生长调节综合测定汇总表
Figure PCTCN2017114516-appb-000005
Figure PCTCN2017114516-appb-000006
注：表3中“丙”为“丙森锌”，“噻”为“噻苯隆”缩写。施药时期：开花期和坐果后期，番茄中后期正是霜霉病等病害发病时期。施药次数：2次。调查时期：番茄成熟期；本试验中，株高、茎径、果径、抗病情况、单颗果重等指标均为各处理的平均值。
据分析表明，1、可以矮化番茄植株，有效控制番茄控旺徒长，增粗番茄茎蔓，增加番茄的抗倒伏能力；2、可以提高单颗番茄的重量，增加果实的品质；3、丙森锌对番茄具有一定的内吸性，对番茄等真菌病害具有一定的保护作用，而噻苯隆对番茄生长具有一定的抗病抗逆能力，两者混配后具有显著的协同增效作用；4、本发明的组合物对番茄的单位产量具有显著的提升作用。
(二)田间药效验证试验
(1)代森锰锌与噻苯隆混配对水稻调节生长及抗病增产的田间综合试验
施药时期：水稻齐穗末期。调查水稻成穗数(每穗有5粒以上实粒数为有效穗)、每穗总粒数、每穗实粒数、结实率、单位亩产量，计算增产率，进行统计分析。
施药次数：1次。利用本发明的制剂实施例进行喷施，三个重复，结果取平均值。
表4代森锰锌与噻苯隆混配对水稻调节生长的田间综合实验
Figure PCTCN2017114516-appb-000007
Figure PCTCN2017114516-appb-000008
试验结果表明，在水稻齐穗末期施用本发明的制剂产品，可以有效调节水稻的健康生长。1、可以矮化水稻植株，有效控制水稻控旺徒长，防止水稻倒伏；2、可以提升水稻的成穗数，提高水稻的结实率；4、代森锰锌对水稻具有一定的内吸性，对水稻纹枯病等真菌病害具有一定的保护作用，而噻苯隆对水稻生长具有一定的抗病抗逆能力，两者混配后具有显著的协同增效作用；5、本发明的组合物对水稻的单位产量具有显著的提升作用
(2)代森联与噻苯隆对苹果作物调节生长及抗病增产的田间综合试验
施药时期：苹果开花期和苹果坐果后进行两次喷雾。
施药次数：2次。利用本发明的制剂实施例进行喷施，三个重复，结果取平均值。
表5代森联与噻苯隆混配对苹果调节生长的田间综合实验
Figure PCTCN2017114516-appb-000009
Figure PCTCN2017114516-appb-000010
试验结果表明，1、代森联与噻苯隆复配对苹果的座果率有显著的提升作用；2、由于座果率的提升，产量也有相应的提升作用；3、由于噻苯隆属于植物内在激素，而代森联对苹果的生长也具有一定的调节作用，两者混配后可以使苹果叶片更厚实，增强光合作用，促进苹果内在营养的传导作用，提高苹果的糖分和水分，因此对苹果的果实有显著的提升作用，果实重量相应提高，从而显著提高苹果的单位产量；4、代森联与噻苯隆的协同作用，可对苹果一些主要病害如轮纹病有显著的预防治疗作用。
(3)丙森锌与噻苯隆对葡萄作物调节生长及抗病增产的田间综合试验
施药时期：分别在葡萄开花前10天和葡萄盛花后12天进行两次喷雾。
施药次数：2次。利用本发明的制剂实施例进行喷施，三个重复，结果取平均值。
表6丙森锌与噻苯隆混配对葡萄调节生长的田间综合实验
Figure PCTCN2017114516-appb-000011
Figure PCTCN2017114516-appb-000012
从上表实验数据分析表明，1、丙森锌与噻苯隆复配对葡萄的座果率有显著的提升作用；2、由于座果率的提升，葡萄后期生长的穗粒数也有相应的提升作用；3、由于噻苯隆属于植物内在激素，而丙森锌对葡萄的生长也具有一定的调节作用，两者混配后可以使葡萄叶片更厚实，增强光合作用，促进葡萄内在营养的传导作用，提高葡萄的糖分和水分，因此对葡萄的籽粒有显著的提升作用，籽粒重量相应提高，从而显著提高葡萄的单位产量；4、丙森锌与噻苯隆的协同作用，可对葡萄一些主要病害如霜霉病有显著的预防治疗作用。

Claims (10)

  1. 一种农药组合物，其特征在于所述的组合物包含A和B两种活性组分，其中活性组分A为硫代氨基甲酸酯类化合物，其中活性组分B为噻苯隆，两组分之间的重量比为(80～5000)∶1。
  2. 根据权利要求1所述的农药组合物，其特征在于：所述的活性组分A为代森锰锌、代森联和丙森锌中的任意一种。
  3. 根据权利要求1所述的农药组合物，其特征在于：活性组分A和活性组分B的重量比为(200～4500)∶1。
  4. 根据权利要求3所述的农药组合物，其特征在于：活性组分A和活性组分B的重量比为(500～4500)∶1
  5. 根据权利要求1～4中任一所述的农药组合物，其特征在于：该农药组合物由活性成分和农药助剂制成农药上允许的剂型。
  6. 根据权利要求1或5所述的农药组合物，其特征在于：该农药组合物由15.0001～90.9999％重量份的活性组分与84.9999～9.0001％重量份的农药助剂组成农药上允许的剂型。
  7. 根据权利要求6所述的农药组合物，其特征在于所述的剂型为水分散粒剂、悬浮剂或可湿性粉剂。
  8. 根据权利要求1～7中任一所述的农药组合物，其特征在于：所述农药助剂选自载体、溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂和肥料中的任意一种或几种。
  9. 权利要求1～8中任一所述的农药组合物在农业领域防病抗病或促进植物生长中的用途。
  10. 根据权利要求9所述的用途，其特征在于：所述的植物为水稻、玉米或果树。
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