[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

WO2018057745A1 - Procédés et dispositifs destiné au positionnement d'une mandibule d'un sujet pour déterminer et manipuler une ouverture des voies respiratoires - Google Patents

Procédés et dispositifs destiné au positionnement d'une mandibule d'un sujet pour déterminer et manipuler une ouverture des voies respiratoires Download PDF

Info

Publication number
WO2018057745A1
WO2018057745A1 PCT/US2017/052731 US2017052731W WO2018057745A1 WO 2018057745 A1 WO2018057745 A1 WO 2018057745A1 US 2017052731 W US2017052731 W US 2017052731W WO 2018057745 A1 WO2018057745 A1 WO 2018057745A1
Authority
WO
WIPO (PCT)
Prior art keywords
subject
airway
measurement
mandible
airflow
Prior art date
Application number
PCT/US2017/052731
Other languages
English (en)
Inventor
William H. Hanewinkel
Michael Brendan GLEESON
Jinesh Jain
Original Assignee
Kosmo Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosmo Technologies, Inc. filed Critical Kosmo Technologies, Inc.
Publication of WO2018057745A1 publication Critical patent/WO2018057745A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/087—Measuring breath flow

Definitions

  • the application relates generally to medical devices and positioning of a mandible of a subject for determining and manipulating an airway opening, for use in treating, for example, breathing disorders involving a patient's airway (e.g. , snoring, sleep apnea, upper respiratory syndrome, etc.). More particularly, but not by way of limitation, the disclosure relates to apparatuses and methods for mandibular manipulation and instant and/or segmented feedback on airway patency using a technique, such as, for example, the noninvasive forced oscillation technique (FOT), impulse oscillometry system (IOS), or another appropriate airway measurement technique.
  • FOT noninvasive forced oscillation technique
  • IOS impulse oscillometry system
  • oral appliances In the field of treating the malady of sleep disorders, oral appliances have been shown to be successful in treating mild to moderate cases.
  • the fitting of an oral appliance through a dentist is thought to pull the tongue forward and prevent the tongue from falling back and creating an airway blockage during sleep.
  • OSA obstructive sleep apnea
  • CPAP continuous positive airway pressure
  • OAT oral appliance therapy
  • OAT has been getting wider recognition as an alternative to positive airway pressure (PAP) devices to treat mild-to-moderate OSA.
  • Oral appliances require no electrical power and are cost effective, quiet, and portable.
  • OAT can be used as a first line treatment, or after patient refusal or intolerance of PAP therapies, or in combination with PAP.
  • Many patients prefer OAT to PAP.
  • Side effects of OAT are low, if fitted correctly, but can include excessive salivation as well as mouth and/or teeth discomfort.
  • Adherence rates for OAT are at least equal to PAP when the oral appliance is fitted properly.
  • Such methods typically include adjusting a position of the subject's mandible with a dental gauge in at least one axis of direction and measuring an airway impedance of the subject utilizing an airway evaluation technique.
  • Devices and systems as disclosed herein may be utilized to perform such methods.
  • an apparatus including an airflow measurement tube with an open end configured to form an airtight seal within the mouth and lip surfaces of a subject.
  • the apparatus may include a dental device coupled with the airflow measurement tube and configured to position a mandible of the subject with respect to a maxilla of the subject.
  • the apparatus may also include at least one sensor coupled with the airflow measurement tube and configured to measure at least one of an airflow through the airflow measurement tube or a pressure within the airflow measurement tube.
  • the dental device may be configured to alter the position of the mandible with respect to the maxilla in at least one orthogonal direction (e.g. , two orthogonal directions).
  • the beginning measurement of airway impedance is triggered at the crossover from the subject's expiration to inspiration.
  • the dental device may be configured to lock in place to maintain the position of the mandible with respect to the maxilla.
  • at least two orthogonal directions define an anterior/posterior position of the mandible with respect to the maxilla and a vertical position of the mandible with respect to the maxilla.
  • the dental device is configured to adjust and position the mandible with respect to the maxilla in the anterior/posterior direction, the vertical direction, and either side of the sagittal plane.
  • the open end of the airflow measurement tube may be configured to form an airtight seal simultaneously to the subject's mouth and the subject's nasal passages.
  • at least one sensor may include a differential pressure sensor or a pitot tube, utilizing a differential pressure sensor.
  • the apparatus may further include an acoustic wave emitter coupled with the airflow measurement tube and configured to induce pressure waves within the airflow measurement tube.
  • the acoustic wave emitter may be configured to induce sinusoidal pressure waves of a single frequency within the airflow measurement tube, to induce pressure waves with a composed pseudo-random waveform or pseudorandom frequencies within the airflow measurement tube, or to induce a single custom waveform shape pressure waves of a single frequency within the airflow measurement tube.
  • the dental device is sealed and the airway impedance measurement may be taken through the subject's nasal passages.
  • Such a method typically includes positioning the subject's mandible in a first position with a dental device, performing a first airway measurement of the subject's airway with the subject's mandible in the first position, positioning the subject's mandible in a second position with the dental device, performing a second airway measurement of the subject's airway with the subject's mandible in the second position, and comparing the first airway measurement and the second airway measurement.
  • positioning the subject's mandible in the first position includes positioning the subject's mandible at a vertical distance from the subject's maxilla.
  • Other embodiments include performing a first airway measurement and performing a second airway measurement comprise measuring a first airway impedance and a second airway impedance using a forced oscillation technique or an impulse Oscillometry spirometer system or an occlusion-type airway measurement technique.
  • the airway impedance measurement may be conducted through the nasal passages while the dental device is sealed.
  • positioning the subject's mandible in the first position includes positioning the subject's mandible at a vertical distance between front incisors and holding that position while an airway impedance measurement is conducted.
  • the airway impedance breathing measurement is triggered (i.e., started) at the crossover from the subject's expiration to inspiration and may be made and reported while the subject is asleep.
  • the oscillating waveform may be recorded in a digital format and played back on a codec circuit card through an amplifier.
  • the vertical position of the mandible or the anterior/posterior position of the mandible may be established to find the lower FOT measurement.
  • the mandible position is used to find the remaining mandible position by a lower FOT measurement. For example, with a nose clamp in place and starting in the habitual bite position, a base line impedance measurement may be taken of the airway of a subject.
  • a second impedance measurement may then be taken at a selected vertical position (e.g., the 6 mm vertical position). Sequential higher vertical positions may be taken while comparing impedance measurements focusing on the lowest measurement and a respective position. Anterior/posterior positions may be started from the lowest impedance vertical position to determine if such a position further lowers the impedance. Such measurements may be performed while the subject is in the awake state and seated. In addition, the comparison of known airway impedance with habitual breathing may result in an ability to screen for obstructive sleep apnea illness.
  • FIG. 1 depicts a titration mouthpiece applied to a patient
  • FIG. 2 is a top perspective view of the titration mouthpiece including a lower incisor slide;
  • FIG. 3 is a bottom perspective view of the titration mouthpiece
  • FIG. 4A is a bottom view of the titration mouthpiece
  • FIG. 6 is an end view of the titration mouthpiece
  • FIG. 7 is a side view of the lower incisor slide
  • FIG. 8 is an end view of the lower incisor slide
  • FIG. 9 is a bottom view of the lower incisor slide
  • FIG. 10 is a schematic description of an FOT device including connections to a dental gauge and a personal computer;
  • FIG. 11 depicts the titration mouthpiece and several lower incisor slides.
  • the disclosure also improves the forced oscillation technique (FOT) device in two ways to minimize its size and weight.
  • FOT forced oscillation technique
  • the pressure sensors were sensitive to humidity, movement of the vinyl tubing, and turbulent airflow.
  • These pneumotachographs utilized electric heaters to prevent condensation and very fine mesh and large diameter screens to create laminar flow.
  • Embodiments of the instant disclosure utilize LDE Series pressure sensors from First Sensor AG of Berlin, Germany. Utilizing these high impedance pressure sensors allows creation of a smaller tube/orifice for the pneumotachograph while eliminating the heater and any laminar flow mechanism.
  • First Sensor LBA Series sensors also create a much improved signal strength and accuracy.
  • PCT Application Publication WO 2016/004004 US filed June 30, 2015, the disclosure of which is hereby incorporated herein in its entirety by this reference.
  • the FOT method can be used to determine patient candidacy for oral appliance therapy and to predict effectiveness. This is a major question that insurance companies are trying to answer because there is no way for them to know the effectiveness of an oral appliance on a per-patient basis before incurring the expense of a custom oral appliance plus titration and follow-up sleep study.
  • the FOT technique offers an objective way to determine the treatment plan for all OSA patients.
  • Embodiments of the disclosure offer the potential to answer major questions that third party payers, clinicians, and dentists are trying to answer while fitting oral appliances as a treatment for sleep disorder breathing.
  • the mandible has at least three degrees of freedom and the vertical opening of the mouth is associated with the rotation and sliding of the temporal mandibular joint.
  • a patient 6 has titration mouthpiece 1 within their mouth such that lips of the patient 6 ensures an airtight seal around the mouthpiece 1.
  • the patient 6 may wear a nasal clamp 5, such as, for example, part no. 5R, which is produced by and commercially available from ARK Therapeutic Services, Inc. of Columbia, SC.
  • a cylindrical end 2 would adapt to a similar shape in an airtight manner as it connects to a forced oscillation technique (FOT) device.
  • FOT forced oscillation technique
  • RESMON PROTM which is produced by and commercially available from MGC Diagnostics, of St. Paul, MN.
  • An arrow 7 indicates a bidirectional flow of breathing performed by the patient 6 through the titration mouthpiece 1.
  • a lower incisor slide 30 may include a tongue depressor 3, which may slide with the mandible of the patient 6 in the direction of arrow 4 relative to the titration mouthpiece 1.
  • FIG. 2 is a top perspective view of the titration mouthpiece 1, which may include a breathing tube 20 and the lower incisor slide 30.
  • the breathing tube 20 and the lower incisor slide 30 may communicate via a dovetail slot 14 such that the breathing tube 20 moves relative to the lower incisor slide 30 in a direction of arrow 24.
  • the lower incisor slide 30 may include a number of lower incisor slides 30, each of which provide various positioning of the subject's mandible in one or more of a vertical direction, to either side of the sagittal plane, or in the anterior/posterior direction.
  • each lower incisor slide 30 may provide a differing distance X (e.g., vertical distance) between the incisor slots 17 and 18 when the lower incisor slide 30 is coupled to the titration mouthpiece 1.
  • each lower incisor slide 30 may provide a differing distance between the incisor slots 17 and 18 when the lower incisor slide 30 moves in other axes, such as to either side of the sagittal plane or in the anterior/posterior direction 24.
  • FIGS. 3, 4A, 5, and 6 include a bottom perspective view, bottom view, side view, an end view, respectively, of the titration mouthpiece 1, and FIG. 4B is a bottom view of the titration mouthpiece 1 including the lower incisor slide 30.
  • the cylindrical end 2 may transition to an oval shape 13 and may be entirely hollow to create a through tube.
  • An open end 15 may be configured to form an airtight seal within the mouth and lip surfaces of the patient 6.
  • the oval shape 13 and flanges 8 and 9 may be configured to insert into the mouth of the patient 6.
  • a sliding block 10 may be held within an annular space of the oval shape 13 by braces 11, 12, 21, and 22.
  • the dovetail slot 14 runs through the sliding block 10.
  • Incisor slots 17 and 18 may be located bottom and top of the sliding block 10 to engage incisors of the patient 6.
  • a cutaway 16 may create an opening in the oval shape 13 to allow the patient 6 lower incisor anterior/posterior motions so as to not have incisor teeth interfere with the oval shape 13.
  • the incisor slots 17 and 18 are spaced to have a nominal 2 mm thickness between them for an initial measurement of habitual airway impedance.
  • portions of lower incisor slide 30 may align with markings in order to obtain a measurement reading. For example, graduated scales or gradation markings or indicators may be marked in the body of the titration mouthpiece 1 in order to accurately quantify the relative position of the lower incisor slide 30.
  • the relative position may be provided by electronic feedback of the positions to be recorded by data logger or other computer recording, thus allowing for an automatic record of the relative position of the relative positions to be recorded by data logger or other computer recording, thus allowing for an automatic record of the measurements.
  • FIGS. 7, 8, and 9 depict a side view, end view, and bottom view, respectively, of the lower incisor slide 30.
  • the lower incisor slide 30 may further include a protrusion 19 (i.e., tenon) for engaging the dovetail slot 14 (i.e., mortise) of the titration mouthpiece 1, which may be secured by various couplings, for example, retaining pin, interlocking clip, friction or interference fit, etc.
  • FIG. 10 is a schematic description of an FOT device including connections to a dental gauge and a personal computer.
  • a flex hose 101 may be attached to the titration mouthpiece 1, at a distal end opposite a proximal insertion end of the titration mouthpiece 1 and may be configured to provide an airway path.
  • a bio- filter 102 may be associated with the airway path.
  • the bio-filter 102 may be connected to the flex hose 101.
  • the bio-filter 102 may be associated within or proximal the titration mouthpiece 1 (e.g. , may be formed as a unitary unit).
  • a pressure port 103 may be operatively connected to the flex hose 101.
  • a sensor for example, a pitot tube 104 (e.g., a bi-directional pitot tube 104) or a differential pressure sensor, may be located along the airway path, and may be located in proximity to the flex hose 101.
  • the bi-directional pitot tube 104 may be located interior or adjacent to the flex hose 101 and may be configured to measure the relative velocity and/or pressure of the airflow.
  • a wye fitting 105 may be associated with the flex hose 101, a bypass port 106, and an acoustic collector 110.
  • the acoustic collector may be connected to a loudspeaker 120 (e.g., sub-woofer) using a gasket 111.
  • the loudspeaker 120 may be similar to or larger or smaller than, for example model TS-W161, 60, which is commercially available from Pioneer of Des Moines, IA. Since some embodiments of this disclosure may not require the low frequency response of the loudspeaker 120 (e.g., around 5 Hz), the device can use a smaller coin size speaker exciter.
  • an amplifier circuit card 112, a codec circuit card 1 13 and/or micro storage media 114 may be in electrical communication with the loudspeaker 120.
  • the pressure port 103 may be in proximity to the bi-directional pitot tube 104, which may be operatively coupled to at least one vinyl tubing 116, which in turn is operatively coupled to at least one pressure sensor 118 associated with a controller circuit card 107.
  • the controller circuit card 107 may be in communication with a processor 108 (e.g., a personal computer) using, for example, a universal serial bus (USB) cable 109. In other embodiments, the controller circuit card 107 may communicate with the processor 108 wirelessly.
  • the personal computer may include a display 119 (e.g., a graphical user interface) and may be equipped with software 115.
  • the software 115 may be generic in nature or may be specifically configured to interact with the system and to record, store and analyze measurements.
  • the processor 108 may be provided with feedback that represents data from the patient 6.
  • real-time physical information of the patient 6 may be utilized by the software 1 15.
  • data transfer 100 may be accomplished either by direct connection or wirelessly between the processor 108 and a central storage unit (not shown). It may be appreciated that any inputs received may be recorded, analyzed, and used as part of a method to indicate a prescribed outcome for the patient by the physician or dentist.
  • FIG. 11 depicts the titration mouthpiece 1 , along with several sizes of lower incisor slides 30.
  • the lower incisor slide 30 may include a number of lower incisor slides 30, each of which provide various positioning of the subject's mandible in one or more of a vertical direction, to either side of the sagittal plane, or in the anterior/posterior direction.
  • Embodiment 1 An apparatus comprising: an airflow measurement tube with an open end configured to form an airtight seal within a mouth and lip surfaces of a subject; a dental device coupled with the airflow measurement tube and configured to position a mandible of the subject with respect to a maxilla of the subject; and at least one sensor coupled with the airflow measurement tube and configured to measure at least one of an airflow through the airflow measurement tube or a pressure within the airflow measurement tube.
  • Embodiment 2 The apparatus of Embodiment 1, wherein the dental device is configured to alter the position of the mandible of the subject with respect to the maxilla of the subject in at least two orthogonal directions.
  • Embodiment 3 The apparatus of Embodiment 1 or Embodiment 2, wherein the dental device is configured to lock in place to maintain the position of the mandible of the subject with respect to the maxilla of the subject.
  • Embodiment 4 The apparatus of Embodiment 2, wherein the at least two orthogonal directions define an anterior/posterior position of the mandible of the subject with respect to the maxilla of the subject and a vertical position of the mandible of the subject with respect to the maxilla of the subject.
  • Embodiment 5 The apparatus of Embodiment 4, wherein the dental device is configured to adjust and position the mandible of the subject with respect to the maxilla of the subject in the anterior/posterior direction, the vertical direction, and either side of a sagittal plane of the subject.
  • Embodiment 6 The apparatus of any of Embodiments 1 through 5, wherein a beginning measurement of airway impedance is triggered at a crossover from expiration to inspiration of the subject.
  • Embodiment 7 The apparatus of any of Embodiments 1 through 6, wherein the open end of the airflow measurement tube is configured to form an airtight seal simultaneously to the mouth and nasal passages of the subject.
  • Embodiment 8 The apparatus of any of Embodiments 1 through 6, wherein the dental device is configured to be sealed such that an airway impedance measurement is taken through nasal passages of the subject.
  • Embodiment 9 The apparatus of Embodiment 1, wherein the at least one sensor comprises a differential pressure sensor.
  • Embodiment 10 The apparatus of Embodiment 1, wherein the at least one sensor comprises a pitot tube.
  • Embodiment 13 The apparatus of Embodiment 11, wherein the acoustic wave emitter is configured to induce pressure waves with a composed pseudo-random waveform within the airflow measurement tube.
  • Embodiment 14 The apparatus of Embodiment 11, wherein the acoustic wave emitter is configured to induce a single custom waveform shape pressure waves of a single frequency within the airflow measurement tube.
  • Embodiment 15 A method of measuring and adjusting an amount of airflow through an airway of a subject, the method comprising: positioning a mandible of the subject in a first position with a dental device; performing a first airway measurement of the airway of the subject with the mandible of the subject in the first position; positioning the mandible of the subject in a second position with the dental device; performing a second airway measurement of the airway of the subject with the mandible of the subject in the second position; and comparing the first airway measurement and the second airway measurement.
  • Embodiment 16 The method of Embodiment 15, wherein positioning the mandible of the subject in the first position comprises positioning the mandible of the subject at a vertical distance from a maxilla of the subject.
  • Embodiment 17 The method of Embodiment 15 or Embodiment 16, wherein performing the first airway measurement and performing the second airway measurement comprise measuring a first airway impedance and a second airway impedance using a forced oscillation technique or an impulse Oscillometry spirometer system.
  • Embodiment 18 The method of Embodiment 15 or Embodiment 16, wherein performing the first airway measurement and performing the second airway measurement comprise measuring a first airway impedance and a second airway impedance using an occlusion-type airway measurement technique.
  • Embodiment 19 The method of any of Embodiments 15 through 18, wherein performing the first airway measurement and performing the second airway measurement comprise conducting each of the first airway measurement and the second airway measurement through nasal passages of the subject while the dental device is sealed.
  • Embodiment 20 The method of any of Embodiments 15 through 19, wherein positioning the mandible of the subject in the first position comprises positioning the mandible of the subject at a vertical distance between front incisors and holding that position while an airway impedance measurement is conducted.
  • Embodiment 21 The method of any of Embodiments 15 through 20, wherein each of the first airway measurement and the second airway measurement is triggered at a crossover from expiration to inspiration of the subject.
  • Embodiment 22 The method of any of Embodiments 15 through 21, wherein performing the first airway measurement and performing the second airway measurement comprise performing and reporting the first airway measurement and the second airway measurement while the subject is asleep.
  • Embodiment 23 The method of Embodiment 15, further comprising recording an oscillating waveform in a digital format and playing back the oscillating waveform on a codec circuit card through an amplifier.
  • Embodiment 24 The method of any of Embodiments 15 through 23, wherein positioning the mandible of the subject comprises establishing a vertical position or an anterior/posterior position of the mandible of the subject to find a lower forced oscillation technique measurement.
  • Embodiment 25 The method of Embodiment 24, wherein establishing the vertical position or the anterior/posterior position of the mandible of the subject comprises using the lower forced oscillation technique measurement to find a remaining mandible position.
  • the term "substantially" in reference to a given parameter means and includes to a degree that one skilled in the art would understand that the given parameter, property, or condition is met with a small degree of variance, such as within acceptable manufacturing tolerances.
  • a parameter that is substantially met may be at least about 90% met, at least about 95% met, or even at least about 99% met.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un procédé et des instruments destinés au montage d'appareils oraux destinés à traiter l'apnée obstructive du sommeil. Des jauges peuvent être utilisées pour positionner une mandibule d'un sujet afin de mesurer une ouverture des voies respiratoires du sujet. Les procédés peuvent comprendre la manipulation de la mandibule pour déterminer et mesurer les voies respiratoires optimisées à l'aide d'une jauge. De telles combinaisons d'une jauge et d'une mesure des voies respiratoires peuvent fournir au médecin praticien une rétroaction immédiate des voies respiratoires lors du montage des appareils oraux.
PCT/US2017/052731 2016-09-23 2017-09-21 Procédés et dispositifs destiné au positionnement d'une mandibule d'un sujet pour déterminer et manipuler une ouverture des voies respiratoires WO2018057745A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662399198P 2016-09-23 2016-09-23
US62/399,198 2016-09-23

Publications (1)

Publication Number Publication Date
WO2018057745A1 true WO2018057745A1 (fr) 2018-03-29

Family

ID=61690029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2017/052731 WO2018057745A1 (fr) 2016-09-23 2017-09-21 Procédés et dispositifs destiné au positionnement d'une mandibule d'un sujet pour déterminer et manipuler une ouverture des voies respiratoires

Country Status (1)

Country Link
WO (1) WO2018057745A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041571A1 (fr) * 1995-06-08 1996-12-27 Resmed Limited Controle de la respiration bucco-nasale
WO1997016151A1 (fr) * 1995-11-01 1997-05-09 University Technologies International Inc. Dispositif de commande adaptative du positionnement mandibulaire et son mode d'emploi
WO2008048471A2 (fr) * 2006-10-13 2008-04-24 Apnex Medical, Inc. Dispositifs, systèmes et procédés de traitement d'apnée du sommeil obstructive
WO2013062785A1 (fr) * 2011-10-27 2013-05-02 Scientific Partners, Llc Système et procédé pour administrer une thérapie et détecter une activité biologique dans la bouche
US20150128941A1 (en) * 2012-04-30 2015-05-14 Resmed Limited Method and apparatus for oral flow therapy

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041571A1 (fr) * 1995-06-08 1996-12-27 Resmed Limited Controle de la respiration bucco-nasale
WO1997016151A1 (fr) * 1995-11-01 1997-05-09 University Technologies International Inc. Dispositif de commande adaptative du positionnement mandibulaire et son mode d'emploi
WO2008048471A2 (fr) * 2006-10-13 2008-04-24 Apnex Medical, Inc. Dispositifs, systèmes et procédés de traitement d'apnée du sommeil obstructive
WO2013062785A1 (fr) * 2011-10-27 2013-05-02 Scientific Partners, Llc Système et procédé pour administrer une thérapie et détecter une activité biologique dans la bouche
US20150128941A1 (en) * 2012-04-30 2015-05-14 Resmed Limited Method and apparatus for oral flow therapy

Similar Documents

Publication Publication Date Title
US9615963B2 (en) Method and apparatus for diagnosing sleep apnea
KR102410884B1 (ko) 환자의 치열교정 진단 분석을 결정하는 시스템 및 방법
KR102264125B1 (ko) 호흡 보조 장치
AU2006281500B2 (en) Device for treating snoring sounds, interruptions in breathing and obstructive sleep apnea
US20190320977A1 (en) Oral appliance monitoring
US20140114146A1 (en) Diagnostic devices, mandibular manipulators with tongue and nasal sensors, automated mandibular manipulators and related methods
CN111918602B (zh) 具有间隔开的多组电气部件的下颌前移装置
US20170135603A1 (en) Methods and devices for positioning of a mandible of a subject for determining an optimal airway opening
WO2015130717A2 (fr) Méthodes et applications de détection du débit respiratoire et système associé
US20100113957A1 (en) System, method and apparatus for monitoring a medical condition
Cimić et al. The relationship between Angle type of occlusion and recorded Bennett angle values
US10709413B2 (en) System and method for analysis of the upper airway and a respiratory pressure support system
Singh et al. Use of a sibilant phoneme registration protocol to prevent upper airway collapse in patients with TMD
CN117320673A (zh) 用于治疗睡眠障碍的牙科矫治器
WO2018057745A1 (fr) Procédés et dispositifs destiné au positionnement d'une mandibule d'un sujet pour déterminer et manipuler une ouverture des voies respiratoires
Smith Oral appliances in the treatment of obstructive sleep apnea
Piskin et al. Comparison of efficacy and usability of custom mandibular advancement devices fabricated with the conventional method and digital workflow: A pilot clinical study
US20230047226A1 (en) Diagnosis and treatment for osa-related bruxism
Van Leeuwen et al. A two-dimensional gauge and protocol for fitting oral appliances used in treating sleep breathing disorders.
KR20220105107A (ko) 폐쇄성 수면 무호흡 진단 및 장치
IT202000004555A1 (it) Dispositivo di avanzamento mandibolare

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17853895

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 17.07.2019)

122 Ep: pct application non-entry in european phase

Ref document number: 17853895

Country of ref document: EP

Kind code of ref document: A1