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WO2017012031A1 - Nerve sensing device capable of suppressing interactive interference - Google Patents

Nerve sensing device capable of suppressing interactive interference Download PDF

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Publication number
WO2017012031A1
WO2017012031A1 PCT/CN2015/084602 CN2015084602W WO2017012031A1 WO 2017012031 A1 WO2017012031 A1 WO 2017012031A1 CN 2015084602 W CN2015084602 W CN 2015084602W WO 2017012031 A1 WO2017012031 A1 WO 2017012031A1
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sensing
signal
control signal
unit array
neuron
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PCT/CN2015/084602
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French (fr)
Chinese (zh)
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林伯刚
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林伯刚
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Priority to PCT/CN2015/084602 priority Critical patent/WO2017012031A1/en
Publication of WO2017012031A1 publication Critical patent/WO2017012031A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/08Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00

Definitions

  • the present disclosure relates to a neural sensing device, and more particularly to a neural sensing device having a suppression of interference to prevent neurons from being interfered with each other by a plurality of dense signals.
  • Second Sight Medical Products Inc. conducted a human transplant for the experimental electronic eye Argus I produced by six blind patients.
  • Argus I is a bionic eye. It has a resolution of 16 pixels, allowing blind patients to recognize the contour of the object through the difference in brightness reflected from the surface of the object.
  • the company released the second-generation Argus II, which upgrades image resolution to 60 pixels, providing users with better resolution and image recognition accuracy.
  • the prior art experimental electronic eye Argus II device includes an image pickup device disposed outside the user and an image receiving wafer disposed in the user body, wherein the image pickup device includes a frame, a miniature camera, and a Image processing unit, a wireless communication module.
  • the frame is removably disposed on the face of the user, and the micro camera and the wireless communication module are disposed thereon.
  • the miniature camera is used to pick up images in front of the user and generate a photographic information.
  • the image processing unit is disposed outside the frame and connected to the miniature camera. The image processing unit receives the photography information of the miniature camera and generates a digital image signal.
  • the wireless communication module receives the digital image information of the image processing unit, and transmits the digital image information to the image receiving wafer.
  • the image receiving wafer is disposed on the retina of the user and is coupled to at least one optic ganglion on the retina of the user.
  • the image receiving chip converts the digital image information into a nerve peak, and transmits the nerve peak to the user's brain through the at least one optic ganglion, so that the user perceives an image.
  • the image receiving chip needs to add more photosensitive cells to the finite-sized wafer to increase the pixel value in order to improve the resolution and recognition rate of the image by the user, and the gap between the photosensitive cells at this time. More recently, it will be easier to make the sense of each photosensitive unit work.
  • the measured signals interfere with each other, reducing the original effective pixel value. Referring to FIG. 1, when the sensing signals of two adjacent photosensitive cells 10 interfere with each other, the signal superimposed between the two adjacent photosensitive cells 10 is higher than a sensing valve of at least one of the user's optic ganglia.
  • At least one optic ganglion of the user will equally recognize the two photosensitive units 10 as a large-area photosensitive unit 11 and transmit the received sensing signals to the user's brain. If all the photosensitive cells 10 interfere with each other, the user will perceive a blurred light and shadow, and cannot recognize the image by the contour of the object, so that the image receiving wafer with high pixels loses the resolution and recognition rate of the user.
  • the present disclosure proposes a neural sensing device having an interference suppression and avoiding interference of a plurality of dense signals with each other, which has the characteristics of small volume and high neurosensory sensitivity and accuracy. It is indeed a technical problem that is urgently solved by all walks of life.
  • the main object of the present disclosure is to provide a neural sensing device with suppressed interference, which can prevent neurons from being subjected to multiple dense signals to each other without sacrificing resolution. Interference, thereby achieving the purpose of improving the sensitivity and accuracy of nerve sensing.
  • the present invention provides a neural sensing device with interference suppression interference, comprising: a sensing unit array configured with a plurality of sensing units, among the plurality of sensing units Each sensing unit generates a sensing signal; a control signal generator connected to the sensing unit array, generating a control signal and outputting the control signal to each of the plurality of sensing units Surrounding the sensing unit, wherein a signal strength of the control signal is lower than a signal strength of the sensing signal to isolate a sensing signal between each sensing unit of the plurality of sensing units, so that Suppressing an interference; and a signal processing module coupled to the sensing unit array and the control signal generator, and generating a processing signal and outputting the processing signal to at least one neuron;
  • the sensing signal is higher than a sensing threshold of the at least one neuron, and the sensing signal is lower than a sensing valve of the at least one neuron value.
  • the sensing unit array may be a photodiode array of an electronic retina wafer, and each of the plurality of sensing units is a photodiode to replace the human retina Photoreceptor cell.
  • control signal generator is configurable on one side of the sensing unit array of an electronic retina wafer and transmits the control signal to the signal processing module.
  • the neural sensing device is directly connectable to at least one ganglion cell on the human retina.
  • the processing signal can be at least one spike.
  • the control signal generator generates a control signal and outputs the control signal to each of the plurality of sensing units when the neural sensing device provided with the present disclosure provides interference suppression Surrounding, a sensing signal is used to isolate between the sensing units of the plurality of sensing units to suppress interaction interference, thereby preventing the at least one neuron from malfunctioning.
  • each of the plurality of sensing units configured on the sensing unit array is based on the image and/or the light source
  • the light intensity distribution in the space generates a sensing signal, and since each of the foregoing control signals is isolated between the plurality of sensing signals, when the sensing unit array senses a densely distributed light intensity change
  • the image and/or the light source are used, at least one of the neurons can be prevented from being interfered with each other by the plurality of sensing signals at the same time, thereby achieving the purpose of improving the sensitivity and accuracy of the nerve sensing.
  • FIG. 1 is a schematic view showing that sensing signals of two adjacent photosensitive cells of a prior art experimental electronic eye interfere with each other;
  • FIG. 2 is a block diagram showing a circuit according to a first embodiment of the present invention, with a neural sensing device for suppressing crosstalk according to the present disclosure
  • FIG. 3 is a schematic diagram showing the appearance of a sensing unit array according to a first embodiment, in accordance with the present disclosure
  • FIG. 4 is a schematic diagram of a neural sensing device with suppression of crosstalk according to the present disclosure, showing a coupling of a sensing signal and a control signal according to the first embodiment;
  • FIG. 5 is a neural sensing device with suppression of crosstalk according to the present disclosure, showing a functional block diagram according to a first embodiment.
  • a neural sensing device with suppressed interference is described below.
  • the neural sensing device with interference suppression interference includes: a sensing unit array 20 , a control signal generator 30 and a signal processing module 40 .
  • the sensing unit array 20 is configured with a plurality of sensing units 21, and each of the plurality of sensing units 21 generates a sensing signal, wherein each sensing signal is higher than one of the at least one neuron 50.
  • the threshold is sensed to cause at least one neuron 50 to sense valid information and transmit the valid information to the brain 60.
  • the sensing unit array 20 is a photodiode array of an electronic retina wafer, and each of the plurality of sensing units 21 is a photodiode, Replacing a photoreceptor cell on the human retina, that is, each of the plurality of sensing units 21 as one pixel for sensing a picture, which is used to inject a plurality of senses from the outside
  • the plurality of photon energies of each of the sensing units 21 are converted into electron free energy and output electrical energy to generate a sensing signal corresponding to the plurality of photon energies, and the sensing signals are transmitted to the signal processing module 40.
  • the control signal generator 30 can be connected to the sensing unit array 20 , and can generate a control signal and output the control signal to each of the plurality of sensing units 21 . Surrounding, wherein a signal strength of the control signal is lower than a signal strength of the sensing signal to isolate a sensing signal between each of the plurality of sensing units to suppress interference; and Each control signal is below the sensing threshold of at least one neuron 50 to avoid sensing at least one neuron 50 of valid information.
  • At least one neuron 50 has a refractory period for a period of time after being stimulated by an action potential due to the inactivation of the sodium ion (Na + ) channel.
  • the first embodiment of the present disclosure temporarily causes at least one neuron 50 around each of the plurality of sensing units 21 to be in an unresponsive period by the feature, and suspends the generation of the at least one sensing unit 21.
  • control signal generator 30 may be disposed on one side of sensing unit array 20 of an electronic retina wafer and may transmit control signals to signal processing module 40.
  • the signal processing module 40 can be coupled to the sensing unit array 20 and the control signal generator 30, which can generate a processing signal and output the processed signal to at least one neuron 50.
  • the neural sensing device can be directly coupled to at least one ganglion cell on the human retina to cause the signal processing module 40 to replace the bipolar cell on the human retina And/or horizontal cells, wherein each of the at least one ganglion cell is a nodular construct composed of at least one neuron 50 of identical function.
  • Bipolar cells are used to enhance signal edge differences and improve the sharpness of images perceived by brain 60, ie sharpens; horizontal cells are used to attenuate image edge differences and reduce the sharpness of images perceived by brain 60, ie Blurring.
  • the processing signal may be at least one spike.
  • the signal processing module 40 couples the sensing signals of each of the plurality of sensing units 21 with the control signals, at least one spike is generated and output to the at least one neuron 50.
  • the sensing unit array 20 is first disposed on a user's retina, and at least one sensing unit 21 on the sensing unit array 20 is oriented toward the outside of the user to sense the user's retina. External image. Additionally, the signal processing module 40 is coupled to the human retina At least one ganglion cell transmits a processing signal to at least one neuron 50. Next, the control signal generator 30 generates a control signal and outputs the control signal to the periphery of each of the plurality of sensing units 21 for isolating between the respective sensing units of the plurality of sensing units. The sensing signal is configured to suppress the plurality of sensing signals from interfering with each other while avoiding malfunctioning of at least one of the neurons 50.
  • each of the plurality of sensing units 21 configured on the sensing unit array 20 is in space according to the image and/or the light source.
  • the light intensity distribution generates a sensing signal, and since each of the foregoing control signals is isolated between the respective sensing signals, when the sensing unit array 20 senses a densely distributed image and/or light source whose intensity is weakly changed, The at least one neuron 50 is prevented from being interfered with each other by a plurality of sensing signals at the same time, thereby achieving the purpose of improving the sensitivity and accuracy of the neural sensing.

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Abstract

A nerve sensing device capable of suppressing interactive interference comprises a sensing unit array (20), a control signal generator (30), and a signal processing module (40). The sensing unit array (20) is provided with multiple sensing units (21). Each of the multiple sensing units (21) generates a sensing signal. The control signal generator (30) is connected to the sensing unit array (20), generates a control signal and outputs the control signal to the circumference of each of the multiple sensing units (21). The signal strength of the control signal is lower than the signal strength of the sensing signal, so as to isolate sensing signals among the sensing units (21) of the multiple sensing units (21), so as to suppress interactive interference. The signal processing module (40) is connected to the sensing unit array (20) and the control signal generator (30), generates a processing signal, and outputs the processing signal to at least one neuron (50). The sensing signal is higher than a sensing threshold of the at least one neuron (50), and the control signal is lower than a sensing threshold of the at least one neuron (50).

Description

具备抑制交互干扰的神经感测装置Neural sensing device with suppression of crosstalk 技术领域Technical field
本公开文本涉及一种神经感测装置,尤其涉及一种具备抑制交互干扰(interference)而可避免神经元受到多个密集信号彼此相互干扰的神经感测装置。The present disclosure relates to a neural sensing device, and more particularly to a neural sensing device having a suppression of interference to prevent neurons from being interfered with each other by a plurality of dense signals.
背景技术Background technique
在2002年,美国第二视力医学产品公司(Second Sight Medical Products Inc.)将其所生产的实验性电子眼Argus I为六位失明患者进行人体移植手术,Argus I是一仿生电子眼(bionic eye),其具有16个像素(pixels)的解析能力,让失明患者可以通过物体表面对光源反射的亮度差异辨识出物体的轮廓。到了2006年,该公司更发表第二代的产品Argus II,其将影像解析能力提升到60个像素,可为使用者提供更佳的解析度和影像辨识的正确率。In 2002, Second Sight Medical Products Inc. conducted a human transplant for the experimental electronic eye Argus I produced by six blind patients. Argus I is a bionic eye. It has a resolution of 16 pixels, allowing blind patients to recognize the contour of the object through the difference in brightness reflected from the surface of the object. In 2006, the company released the second-generation Argus II, which upgrades image resolution to 60 pixels, providing users with better resolution and image recognition accuracy.
现有技术中的实验性电子眼Argus II的装置包括置于使用者体外的一影像拾取装置以及置于使用者体内的一影像接收晶片,其中该影像拾取装置包括一镜架、一微型摄影机、一影像处理单元、一无线通讯模块。该镜架可移除地配置于使用者的脸上,且其上配置有该微型摄影机和该无线通讯模块。该微型摄影机用于拾取使用者前方的影像,并生成一摄影信息。该影像处理单元配置于该镜架之外,且连接至该微型摄影机。该影像处理单元接收该微型摄影机的摄影信息,并生成一数字影像信号。此时,该无线通讯模块接收该影像处理单元的数字影像信息,并将该数字影像信息传输给该影像接收晶片。该影像接收晶片配置于使用者的视网膜上,且连接于使用者的视网膜上的至少一个视神经节。该影像接收晶片是将数字影像信息转换成一神经尖峰,并通过该至少一个视神经节将该神经尖峰传输于使用者的大脑,让使用者感知到一影像。The prior art experimental electronic eye Argus II device includes an image pickup device disposed outside the user and an image receiving wafer disposed in the user body, wherein the image pickup device includes a frame, a miniature camera, and a Image processing unit, a wireless communication module. The frame is removably disposed on the face of the user, and the micro camera and the wireless communication module are disposed thereon. The miniature camera is used to pick up images in front of the user and generate a photographic information. The image processing unit is disposed outside the frame and connected to the miniature camera. The image processing unit receives the photography information of the miniature camera and generates a digital image signal. At this time, the wireless communication module receives the digital image information of the image processing unit, and transmits the digital image information to the image receiving wafer. The image receiving wafer is disposed on the retina of the user and is coupled to at least one optic ganglion on the retina of the user. The image receiving chip converts the digital image information into a nerve peak, and transmits the nerve peak to the user's brain through the at least one optic ganglion, so that the user perceives an image.
然而,现有技术中的该影像接收晶片为了提高使用者对影像的解析度和辨识率,需要在有限大小的晶片上增加更多的感光单元以提高像素数值,此时各感光单元间的间隙更近,将更容易使得各个感光单元在工作时生成的感 测信号彼此相互干扰,而降低了原始的有效像素数值。请参阅图1,当两个相邻感光单元10的感测信号彼此干扰时,这两个相邻感光单元10之间所叠加的信号若高于使用者的至少一个视神经节的一感测阀值,则使用者的至少一个视神经节会把两个感光单元10等同地辨识为一个大面积的感光单元11,并将所接收到的感测信号传输到使用者的大脑。如果所有感光单元10都彼此干扰,则使用者将感知到一模糊的光影,而无法借助物体轮廓来辨识影像,使得具有高像素的影像接收晶片丧失提高使用者对影像的解析度和辨识率的功能。However, in the prior art, the image receiving chip needs to add more photosensitive cells to the finite-sized wafer to increase the pixel value in order to improve the resolution and recognition rate of the image by the user, and the gap between the photosensitive cells at this time. More recently, it will be easier to make the sense of each photosensitive unit work. The measured signals interfere with each other, reducing the original effective pixel value. Referring to FIG. 1, when the sensing signals of two adjacent photosensitive cells 10 interfere with each other, the signal superimposed between the two adjacent photosensitive cells 10 is higher than a sensing valve of at least one of the user's optic ganglia. For example, at least one optic ganglion of the user will equally recognize the two photosensitive units 10 as a large-area photosensitive unit 11 and transmit the received sensing signals to the user's brain. If all the photosensitive cells 10 interfere with each other, the user will perceive a blurred light and shadow, and cannot recognize the image by the contour of the object, so that the image receiving wafer with high pixels loses the resolution and recognition rate of the user. Features.
因此,本公开文本提出一种具备抑制交互干扰(interference)且可避免神经元受到多个密集信号彼此干扰的神经感测装置,其兼顾具有体积小且高神经感测灵敏度和准确率的特性,确实是目前各界迫切解决的技术问题。Accordingly, the present disclosure proposes a neural sensing device having an interference suppression and avoiding interference of a plurality of dense signals with each other, which has the characteristics of small volume and high neurosensory sensitivity and accuracy. It is indeed a technical problem that is urgently solved by all walks of life.
发明内容Summary of the invention
(一)要解决的技术问题(1) Technical problems to be solved
鉴于前述的现有技术的缺点,本公开文本的主要目的在于提供一种具备抑制交互干扰的神经感测装置,其可在不牺牲解析度的前提之下,避免神经元受到多个密集信号彼此干扰,进而实现提高神经感测灵敏度和准确率的目的。In view of the aforementioned shortcomings of the prior art, the main object of the present disclosure is to provide a neural sensing device with suppressed interference, which can prevent neurons from being subjected to multiple dense signals to each other without sacrificing resolution. Interference, thereby achieving the purpose of improving the sensitivity and accuracy of nerve sensing.
(二)技术方案(2) Technical plan
为了达到前述目的和其他目的,本公开文本所提供的具备抑制交互干扰的神经感测装置,包括:一感测单元阵列,其配置有多个感测单元,所述多个感测单元中的每一个感测单元生成一感测信号;一控制信号生成器,其连接至所述感测单元阵列,生成一控制信号并将所述控制信号输出到所述多个感测单元中的每一个感测单元的周围,其中,所述控制信号的信号强度低于所述感测信号的信号强度,用以隔绝在所述多个感测单元的各个感测单元之间的感测信号,以便抑制交互干扰(interference);以及一信号处理模块,其连接至所述感测单元阵列和所述控制信号生成器,且生成一处理信号并且将所述处理信号输出到至少一个神经元;其中,所述感测信号高于所述至少一个神经元的一感测阀值,以及所述控制信号低于所述至少一个神经元的感测阀 值。In order to achieve the foregoing and other objects, the present invention provides a neural sensing device with interference suppression interference, comprising: a sensing unit array configured with a plurality of sensing units, among the plurality of sensing units Each sensing unit generates a sensing signal; a control signal generator connected to the sensing unit array, generating a control signal and outputting the control signal to each of the plurality of sensing units Surrounding the sensing unit, wherein a signal strength of the control signal is lower than a signal strength of the sensing signal to isolate a sensing signal between each sensing unit of the plurality of sensing units, so that Suppressing an interference; and a signal processing module coupled to the sensing unit array and the control signal generator, and generating a processing signal and outputting the processing signal to at least one neuron; The sensing signal is higher than a sensing threshold of the at least one neuron, and the sensing signal is lower than a sensing valve of the at least one neuron value.
较佳地,所述感测单元阵列可以是一电子视网膜晶片的一光电二极管阵列(photodiode array),所述多个感测单元中的每一个感测单元是一光电二极管,以取代人类视网膜上的感光细胞(photoreceptor cell)。Preferably, the sensing unit array may be a photodiode array of an electronic retina wafer, and each of the plurality of sensing units is a photodiode to replace the human retina Photoreceptor cell.
较佳地,所述控制信号生成器可配置于一电子视网膜晶片的所述感测单元阵列的一侧上,且将所述控制信号传输至所述信号处理模块。Preferably, the control signal generator is configurable on one side of the sensing unit array of an electronic retina wafer and transmits the control signal to the signal processing module.
较佳地,所述神经感测装置可直接连接至人类视网膜上的至少一个神经节细胞(ganglion cell)。Preferably, the neural sensing device is directly connectable to at least one ganglion cell on the human retina.
较佳地,所述处理信号可以是至少一个尖峰(spike)。Preferably, the processing signal can be at least one spike.
(三)有益效果(3) Beneficial effects
本公开文本实施例至少具有如下有益效果:The embodiments of the present disclosure have at least the following beneficial effects:
开始使用本公开文本提供的具备抑制交互干扰的神经感测装置时,所述控制信号生成器生成控制信号并且将所述控制信号输出至所述多个感测单元中的每一个感测单元的周围,用以隔绝在所述多个感测单元中的各个感测单元之间的感测信号,以便抑制交互干扰(interference),从而避免所述至少一个神经元发生误动作。当所述感测单元阵列感测到影像和/或光源时,所述感测单元阵列上所配置的所述多个感测单元中的每一个感测单元就根据该影像和/或该光源在空间中的光强弱分布生成感测信号,而由于前述各个控制信号隔离在所述多个感测信号之间,故当所述感测单元阵列感测到密集分布的光强弱变化的影像和/或光源时,可避免至少一个神经元同时受到多个感测信号彼此相互干扰,进而能够达到提高神经感测灵敏度和准确率的目的。The control signal generator generates a control signal and outputs the control signal to each of the plurality of sensing units when the neural sensing device provided with the present disclosure provides interference suppression Surrounding, a sensing signal is used to isolate between the sensing units of the plurality of sensing units to suppress interaction interference, thereby preventing the at least one neuron from malfunctioning. When the sensing unit array senses an image and/or a light source, each of the plurality of sensing units configured on the sensing unit array is based on the image and/or the light source The light intensity distribution in the space generates a sensing signal, and since each of the foregoing control signals is isolated between the plurality of sensing signals, when the sensing unit array senses a densely distributed light intensity change When the image and/or the light source are used, at least one of the neurons can be prevented from being interfered with each other by the plurality of sensing signals at the same time, thereby achieving the purpose of improving the sensitivity and accuracy of the nerve sensing.
附图说明DRAWINGS
为了更清楚地说明本公开文本实施例或现有技术中的技术方案,下面将对实施例描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本公开文本的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他的附图。In order to more clearly illustrate the embodiments of the present disclosure or the technical solutions in the prior art, the drawings used in the description of the embodiments will be briefly described below. It is obvious that the drawings in the following description are only the present disclosure. Some embodiments of the text may also be used to obtain other figures from these figures without departing from the art.
图1是示出现有技术的实验性电子眼的两个相邻感光单元的感测信号彼此干扰的示意图; 1 is a schematic view showing that sensing signals of two adjacent photosensitive cells of a prior art experimental electronic eye interfere with each other;
图2是根据本公开文本的具备抑制交互干扰的神经感测装置,示出了根据第一实施例的一电路方框示意图;2 is a block diagram showing a circuit according to a first embodiment of the present invention, with a neural sensing device for suppressing crosstalk according to the present disclosure;
图3是根据本公开文本的具备抑制交互干扰的神经感测装置,示出了根据第一实施例的一感测单元阵列的外观示意图;3 is a schematic diagram showing the appearance of a sensing unit array according to a first embodiment, in accordance with the present disclosure;
图4是根据本公开文本的具备抑制交互干扰的神经感测装置,示出了根据第一实施例的一感测信号和一控制信号耦合的示意图;以及4 is a schematic diagram of a neural sensing device with suppression of crosstalk according to the present disclosure, showing a coupling of a sensing signal and a control signal according to the first embodiment;
图5是根据本公开文本的具备抑制交互干扰的神经感测装置,示出了根据第一实施例的功能方框示意图。5 is a neural sensing device with suppression of crosstalk according to the present disclosure, showing a functional block diagram according to a first embodiment.
附图标记说明Description of the reference numerals
10  感光单元10 photosensitive unit
11  感光单元11 photosensitive unit
20  感测单元阵列20 sensing unit array
21  感测单元21 sensing unit
30  控制信号生成器30 control signal generator
40  信号处理模块40 signal processing module
50  神经元50 neurons
60  大脑60 brain
具体实施方式detailed description
下面结合附图和实施例,对本公开文本的具体实施方式做进一步描述。以下实施例仅用于说明本公开文本,但不用来限制本公开文本的范围。The specific embodiments of the present disclosure are further described below in conjunction with the accompanying drawings and embodiments. The following examples are only intended to illustrate the disclosure, but are not intended to limit the scope of the disclosure.
为使本公开文本实施例的目的、技术方案和优点更加清楚,下面将结合本公开文本实施例的附图,对本公开文本实施例的技术方案进行清楚、完整地描述。显然,所描述的实施例是本公开文本的一部分实施例,而不是全部的实施例。基于所描述的本公开文本的实施例,本领域普通技术人员所获得的所有其他实施例,都属于本公开文本保护的范围。The technical solutions of the embodiments of the present disclosure will be clearly and completely described in the following description of the embodiments of the present disclosure. It is apparent that the described embodiments are part of the embodiments of the present disclosure, and not all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the described embodiments of the present disclosure are within the scope of the disclosure.
除非另作定义,此处使用的技术术语或者科学术语应当为本公开文本所属领域内具有一般技能的人士所理解的通常意义。本公开文本专利申请说明书以及权利要求书中使用的“第一”、“第二”以及类似的词语并不表示任何顺 序、数量或者重要性,而只是用来区分不同的组成部分。同样,“一个”或者“一”等类似词语也不表示数量限制,而是表示存在至少一个。“连接”或者“相连”等类似的词语并非限定于物理的或者机械的连接,而是可以包括电性的连接,不管是直接的还是间接的。“上”、“下”、“左”、“右”等仅用于表示相对位置关系,当被描述对象的绝对位置改变后,则该相对位置关系也相应地改变。Unless otherwise defined, technical terms or scientific terms used herein shall be taken to mean the ordinary meaning of the ordinary skill in the art to which this disclosure belongs. The words "first", "second" and similar terms used in the specification and claims of the present disclosure do not indicate any Order, quantity, or importance, but only to distinguish between different components. Similarly, the words "a" or "an" and the like do not denote a quantity limitation, but mean that there is at least one. The words "connected" or "connected" and the like are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Upper", "lower", "left", "right", etc. are only used to indicate the relative positional relationship, and when the absolute position of the object to be described is changed, the relative positional relationship is also changed accordingly.
可以理解的是,本说明书附图所绘示的结构、比例、大小等,均仅用以配合说明书所揭示的内容,以供熟悉本领域技术的人员了解与阅读,并非用以限定本公开文本可实施的限定条件,故不具有技术上的实质意义,任何结构的修饰、比例关系的改变或大小的调整,在不影响本公开文本所能产生的功效和所能达成的目的下,均应落在本公开文本所揭示的技术内容能够涵盖的范围内。It should be understood that the structures, the proportions, the sizes, and the like, which are illustrated in the drawings of the present specification, are only used for the purpose of the disclosure, and are understood by those skilled in the art, and are not intended to limit the present disclosure. The qualifications that can be implemented are not technically meaningful, and any modification of the structure, change of the proportional relationship, or adjustment of the size should be performed without affecting the effects and objectives of the present disclosure. It is within the scope of the technical content disclosed in the present disclosure.
以下依据本公开文本的第一实施例,描述一具备抑制交互干扰的神经感测装置。In accordance with a first embodiment of the present disclosure, a neural sensing device with suppressed interference is described below.
请参阅图2和图3所示,本公开文本提供的具有抑制交互干扰的神经感测装置包括:一感测单元阵列20、一控制信号生成器30和一信号处理模块40。其中,感测单元阵列20配置有多个感测单元21,多个感测单元21中的每一个感测单元生成一感测信号,其中,各个感测信号高于至少一个神经元50的一感测阀值,用以使得至少一个神经元50感测到有效信息,并将该有效信息传输给大脑60。依据本公开文本的第一实施例,感测单元阵列20为一电子视网膜晶片的一光电二极管阵列(photodiode array),多个感测单元21中的每一个感测单元21为一光电二极管,以取代人类视网膜上的感光细胞(photoreceptor cell),即多个感测单元21中的每一个感测单元21作为用于感测画面的一个像素(pixel),其用以将自外界入射至多个感测单元21中的每一个感测单元21的多个光子能量转换为电子游离能量并输出电能,以生成相对应多个光子能量的感测信号,并将感测信号传输给信号处理模块40。Referring to FIG. 2 and FIG. 3 , the neural sensing device with interference suppression interference provided by the present disclosure includes: a sensing unit array 20 , a control signal generator 30 and a signal processing module 40 . The sensing unit array 20 is configured with a plurality of sensing units 21, and each of the plurality of sensing units 21 generates a sensing signal, wherein each sensing signal is higher than one of the at least one neuron 50. The threshold is sensed to cause at least one neuron 50 to sense valid information and transmit the valid information to the brain 60. According to the first embodiment of the present disclosure, the sensing unit array 20 is a photodiode array of an electronic retina wafer, and each of the plurality of sensing units 21 is a photodiode, Replacing a photoreceptor cell on the human retina, that is, each of the plurality of sensing units 21 as one pixel for sensing a picture, which is used to inject a plurality of senses from the outside The plurality of photon energies of each of the sensing units 21 are converted into electron free energy and output electrical energy to generate a sensing signal corresponding to the plurality of photon energies, and the sensing signals are transmitted to the signal processing module 40.
请参阅图2至图4所示,控制信号生成器30可连接到感测单元阵列20,可生成一控制信号并将该控制信号输出至多个感测单元21中的每一个感测单元21的周围,其中,控制信号的信号强度低于感测信号的信号强度,用以隔绝在多个感测单元中的各个感测单元21之间的感测信号,以抑制交互干扰 (interference);以及各个控制信号低于至少一个神经元50的感测阀值,用以避免使至少一个神经元50感测到有效信息。此外,依据神经传导理论指出,至少一个神经元50在经过一动作电位刺激之后由于钠离子(Na+)通道的不活化而具有一段时间呈现不反应期(refractory period)。当至少一个神经元50处于不反应期的期间将无法对其他动作电位的刺激做出反应。本公开文本的第一实施例就借助此特性使多个感测单元21中的每一个感测单元21的周围的至少一个神经元50暂时处于不反应期,中止至少一个感测单元21生成的感测信号在其周围构成连锁反应(chain reaction),而避免干扰到其他的感测单元,故不会有相邻感测单元21之间所叠加的信号强度高于至少一个神经元50的感测阀值的现象发生,且由于各个控制信号的信号强度都未达到至少一个神经元50的感测阀值,故不会对至少一个神经元50构成有效信息而影响大脑60对欲感测画面的辨识。依据本公开文本的第一实施例,控制信号生成器30可配置于一电子视网膜晶片的感测单元阵列20的一侧上,且可将控制信号传输至信号处理模块40。Referring to FIG. 2 to FIG. 4 , the control signal generator 30 can be connected to the sensing unit array 20 , and can generate a control signal and output the control signal to each of the plurality of sensing units 21 . Surrounding, wherein a signal strength of the control signal is lower than a signal strength of the sensing signal to isolate a sensing signal between each of the plurality of sensing units to suppress interference; and Each control signal is below the sensing threshold of at least one neuron 50 to avoid sensing at least one neuron 50 of valid information. Furthermore, according to the theory of nerve conduction, it is pointed out that at least one neuron 50 has a refractory period for a period of time after being stimulated by an action potential due to the inactivation of the sodium ion (Na + ) channel. When at least one of the neurons 50 is in an unresponsive period, it will not be able to respond to stimulation of other action potentials. The first embodiment of the present disclosure temporarily causes at least one neuron 50 around each of the plurality of sensing units 21 to be in an unresponsive period by the feature, and suspends the generation of the at least one sensing unit 21. The sensing signal forms a chain reaction around it, and avoids interference with other sensing units, so there is no sense that the signal intensity superimposed between adjacent sensing units 21 is higher than that of at least one neuron 50. The phenomenon of measuring the threshold occurs, and since the signal strength of each control signal does not reach the sensing threshold of at least one neuron 50, it does not constitute effective information for at least one neuron 50 and affects the brain 60 to sense the picture. Identification. In accordance with a first embodiment of the present disclosure, control signal generator 30 may be disposed on one side of sensing unit array 20 of an electronic retina wafer and may transmit control signals to signal processing module 40.
请参阅图2和图5所示,信号处理模块40可连接至感测单元阵列20和控制信号生成器30,可生成处理信号并且将该处理信号输出到至少一个神经元50。依据本公开文本的第一实施例,神经感测装置可直接连接至人类视网膜上的至少一个神经节细胞(ganglion cell),用以使信号处理模块40取代人类视网膜上的双极细胞(bipolar cell)和/或水平细胞(horizontal cell),其中,至少一个神经节细胞中的每一个是由功能相同的至少一个神经元50所集合而成的结节状构造体。双极细胞用于增强信号边缘差异,提高大脑60所感知的影像的锐利度,即锐利化(sharpen);而水平细胞用于减弱影像边缘差异,降低大脑60所感知的影像的锐利度,即模糊化(blur)。Referring to FIGS. 2 and 5, the signal processing module 40 can be coupled to the sensing unit array 20 and the control signal generator 30, which can generate a processing signal and output the processed signal to at least one neuron 50. According to a first embodiment of the present disclosure, the neural sensing device can be directly coupled to at least one ganglion cell on the human retina to cause the signal processing module 40 to replace the bipolar cell on the human retina And/or horizontal cells, wherein each of the at least one ganglion cell is a nodular construct composed of at least one neuron 50 of identical function. Bipolar cells are used to enhance signal edge differences and improve the sharpness of images perceived by brain 60, ie sharpens; horizontal cells are used to attenuate image edge differences and reduce the sharpness of images perceived by brain 60, ie Blurring.
在本公开文本的第一实施例中,处理信号可以是至少一个尖峰(spike)。信号处理模块40将多个感测单元21中的每一个感测单元21的感测信号与控制信号进行耦合之后,生成并输出至少一个尖峰给至少一个神经元50。In a first embodiment of the present disclosure, the processing signal may be at least one spike. After the signal processing module 40 couples the sensing signals of each of the plurality of sensing units 21 with the control signals, at least one spike is generated and output to the at least one neuron 50.
在开始使用本发明时,先将感测单元阵列20配置于一使用者的视网膜上,且使感测单元阵列20上的至少一个感测单元21朝向使用者外侧,以感测使用者视网膜之外的影像。另外,将信号处理模块40连接至人类视网膜上 的至少一个神经节细胞,以传输处理信号给至少一个神经元50。接着,控制信号生成器30生成控制信号并将该控制信号输出至多个感测单元21中的每一个感测单元21的周围,用以隔绝在多个感测单元中的各个感测单元之间的感测信号,以抑制多个感测信号互相干扰,而避免使至少一个神经元50发生误动作。当感测单元阵列20感测到影像和/或光源时,感测单元阵列20上所配置的多个感测单元21中的每一个感测单元21即依据影像和/或光源在空间中的光强弱分布生成感测信号,而由于前述各个控制信号隔离于各个感测信号之间,因此当感测单元阵列20感测到密集分布的光强弱变化的影像和/或光源时,可避免至少一个神经元50同时受到多个感测信号彼此相互干扰,进而能够达到提高神经感测灵敏度和准确率的目的。When the invention is initially used, the sensing unit array 20 is first disposed on a user's retina, and at least one sensing unit 21 on the sensing unit array 20 is oriented toward the outside of the user to sense the user's retina. External image. Additionally, the signal processing module 40 is coupled to the human retina At least one ganglion cell transmits a processing signal to at least one neuron 50. Next, the control signal generator 30 generates a control signal and outputs the control signal to the periphery of each of the plurality of sensing units 21 for isolating between the respective sensing units of the plurality of sensing units. The sensing signal is configured to suppress the plurality of sensing signals from interfering with each other while avoiding malfunctioning of at least one of the neurons 50. When the sensing unit array 20 senses an image and/or a light source, each of the plurality of sensing units 21 configured on the sensing unit array 20 is in space according to the image and/or the light source. The light intensity distribution generates a sensing signal, and since each of the foregoing control signals is isolated between the respective sensing signals, when the sensing unit array 20 senses a densely distributed image and/or light source whose intensity is weakly changed, The at least one neuron 50 is prevented from being interfered with each other by a plurality of sensing signals at the same time, thereby achieving the purpose of improving the sensitivity and accuracy of the neural sensing.
尽管已参考本申请的许多说明性实施例描述了实施方式,但应了解的是,本领域技术人员能够想到多种其他改变和实施例,这些改变和实施例将落入本发明原理的精神和范围内。尤其是,在本公开、图式以及所附申请专利范围的范围内,对主题结合配置的组成部分和/或配置可作出各种变化与修饰。除对组成部分和/或配置做出的变化与修饰之外,可替代的用途对本领域技术人员而言将是显而易见的。 While the embodiments have been described with reference to the exemplary embodiments of the embodiments of the invention, it will be understood that Within the scope. In particular, various changes and modifications can be made in the components and/or arrangements of the subject combinations. Alternative uses will be apparent to those skilled in the art, in addition to variations and modifications in the component parts and/or configuration.

Claims (5)

  1. 一种具备抑制交互干扰的神经感测装置,包括:A nerve sensing device with suppressed interference, comprising:
    一感测单元阵列,其配置有多个感测单元,所述多个感测单元中的每一个感测单元生成一感测信号;a sensing unit array configured with a plurality of sensing units, each of the plurality of sensing units generating a sensing signal;
    一控制信号生成器,其连接至所述感测单元阵列,生成一控制信号并且将所述控制信号输出至所述多个感测单元中的每一个感测单元的周围,其中,所述控制信号的信号强度低于所述感测信号的信号强度,用以隔绝在所述多个感测单元中的各个感测单元之间的感测信号,以便抑制交互干扰;以及a control signal generator coupled to the sensing unit array, generating a control signal and outputting the control signal to a periphery of each of the plurality of sensing units, wherein the controlling A signal strength of the signal is lower than a signal strength of the sensing signal to isolate a sensing signal between each of the plurality of sensing units to suppress crosstalk;
    一信号处理模块,其连接至所述感测单元阵列和所述控制信号生成器,生成一处理信号并将所述处理信号输出到至少一个神经元,a signal processing module coupled to the sensing unit array and the control signal generator, generating a processing signal and outputting the processing signal to at least one neuron,
    其中,所述感测信号高于所述至少一个神经元的一感测阀值,并且所述控制信号低于所述至少一个神经元的感测阀值。Wherein the sensing signal is higher than a sensing threshold of the at least one neuron, and the control signal is lower than a sensing threshold of the at least one neuron.
  2. 根据权利要求1所述的具备抑制交互干扰的神经感测装置,其中,所述感测单元阵列为一电子视网膜晶片的一光电二极管阵列,所述多个感测单元中的每一个感测单元为一光电二极管,以取代人类视网膜上的感光细胞。The neural sensing device with interference suppression interference according to claim 1, wherein the sensing unit array is a photodiode array of an electronic retina wafer, and each of the plurality of sensing units A photodiode to replace photoreceptor cells on the human retina.
  3. 根据权利要求1所述的具备抑制交互干扰的神经感测装置,其中,所述控制信号生成器配置于一电子视网膜晶片的所述感测单元阵列的一侧上,且将所述控制信号传输至所述信号处理模块。The neural sensing device with interference suppression according to claim 1, wherein the control signal generator is disposed on one side of the sensing unit array of an electronic retina wafer, and transmits the control signal To the signal processing module.
  4. 根据权利要求1所述的具备抑制交互干扰的神经感测装置,其中,所述神经感测模块直接连接至人类视网膜上的至少一个神经节细胞。The neurosensory device with interference suppression according to claim 1, wherein the neural sensing module is directly connected to at least one ganglion cell on a human retina.
  5. 根据权利要求1所述的具备抑制交互干扰的神经感测装置,其中,所述处理信号为至少一个尖峰。 The neural sensing device with suppressed interference according to claim 1, wherein the processed signal is at least one peak.
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