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WO2016185525A1 - Brain electrode - Google Patents

Brain electrode Download PDF

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Publication number
WO2016185525A1
WO2016185525A1 PCT/JP2015/064080 JP2015064080W WO2016185525A1 WO 2016185525 A1 WO2016185525 A1 WO 2016185525A1 JP 2015064080 W JP2015064080 W JP 2015064080W WO 2016185525 A1 WO2016185525 A1 WO 2016185525A1
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WO
WIPO (PCT)
Prior art keywords
brain
electrode
brain electrode
base
bending
Prior art date
Application number
PCT/JP2015/064080
Other languages
French (fr)
Japanese (ja)
Inventor
荻野　滋
Original Assignee
合同会社プロモベオ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 合同会社プロモベオ filed Critical 合同会社プロモベオ
Priority to JP2017518635A priority Critical patent/JPWO2016185525A1/en
Priority to PCT/JP2015/064080 priority patent/WO2016185525A1/en
Publication of WO2016185525A1 publication Critical patent/WO2016185525A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A61B5/293—Invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode

Definitions

  • the present invention relates to a brain electrode that can be inserted into the brain.
  • an electrode hereinafter referred to as a brain electrode
  • a weak electrical signal cell action potential
  • Patent Document 1 discloses a nerve electrode in which a plurality of electrode wirings including an electrode part and a wiring part are provided on an insulating layer made of a flexible insulating material.
  • the nerve electrode is used to give an electrical stimulus to the brain or to measure an electrical activity of the brain while being inserted into the brain.
  • the present invention has been made in view of these points, and an object thereof is to provide a brain electrode having a simple structure that can be appropriately inserted into a deep part of the brain by an insertion member.
  • the first aspect of the present invention is a brain electrode that can be inserted into the brain, and has a planar base, an electrode formed on the base, and a curved surface that extends from one end of the base.
  • a brain electrode including a flexible bending portion is provided.
  • the said bending part is good also as having the said curved surface formed in circular arc shape.
  • the bent portion may be formed in a bowl shape.
  • the bent portion may be formed in a bent shape, and the base portion may have a locking portion that is locked to a distal end side of the bent portion of the bent shape.
  • the bent portion may have an engagement hole in which a distal end side of an insertion member for inserting the brain electrode into the brain can be engaged.
  • a brain electrode having a simple structure that can be appropriately inserted into the deep part of the brain by the insertion member.
  • FIG. 1 is a schematic plan view showing a configuration of a brain electrode 1 according to a first embodiment of the present invention.
  • 1 is a schematic cross-sectional view showing a configuration of a brain electrode 1. It is a schematic diagram for demonstrating the usage form of the brain electrode.
  • 4 is a flowchart for explaining a method of manufacturing the brain electrode 1. It is a figure for demonstrating the formation method of the bending part. It is a figure for demonstrating the structure of the brain electrode 200 which concerns on 2nd Embodiment.
  • FIG. 4 is a development view showing a base material 260 before forming a bent portion 220 of a brain electrode 200.
  • FIG. 1 is a schematic plan view showing the configuration of the brain electrode 1 according to the first embodiment.
  • FIG. 2 is a schematic cross-sectional view showing the configuration of the brain electrode 1.
  • FIG. 3 is a schematic diagram for explaining a usage pattern of the brain electrode 1.
  • the brain electrode 1 is an electrode that can be inserted deep in the brain and is used to elucidate various activities of the brain.
  • the brain electrode 1 is inserted into the brain by an insertion member.
  • the brain electrode 1 is pushed by a needle 70 (FIG. 3) inserted into the brain and inserted into the brain together with the needle 70.
  • the insertion member is not limited to the needle 70, and may be, for example, an optical fiber or a thin tube.
  • the brain electrode 1 may be inserted into the brain by pressing the brain electrode 1 without using an insertion member.
  • the brain electrode 1 is inserted here, for example, 10 to 100 (mm), but may be inserted 100 (mm) or more.
  • the brain electrode 1 detects an electrical signal indicating the activity of the cranial nerve tissue while being inserted into the brain. As shown in FIGS. 1 and 2, the brain electrode 1 includes a base portion 10, an electrode portion 12, and a bending portion 20.
  • the base 10 is a planar part.
  • the base 10 has a structure in which, for example, polyimide is laminated (specifically, two layers). Further, the base 10 is formed to be as thin as 20 ( ⁇ m), for example, and has flexibility. In such a case, the brain electrode 1 inserted into the brain can bend following the movement of the soft cranial nerve tissue. As a result, it is possible to suppress the displacement of the detection position relative to the cranial nerve tissue by moving the entire brain electrode 1 within the brain, and it is possible to suppress the brain electrode 1 from breaking.
  • the whole base 10 is shown as a plane of uniform thickness, it is not limited to this.
  • the base 10 may have an uneven portion in part.
  • the thickness of the base 10 may be non-uniform.
  • the electrode part 12 is formed so as to be exposed from the base part 10. In FIG. 1, three electrode portions 12 are shown, but the number of electrode portions 12 is arbitrary.
  • the electrode part 12 is exposed from at least one surface of both surfaces of the base 10 so that it can contact with a cranial nerve tissue.
  • the electrode unit 12 is in contact with the cranial nerve tissue in a state where the brain electrode 1 is inserted into the brain, and detects an electrical signal (for example, a potential change) generated by the cranial nerve tissue.
  • the electrode part 12 is connected to a wiring pattern 14 formed in the base part 10.
  • the wiring pattern 14 is connected to a terminal 16 that can be connected to an external device.
  • the electrical signal detected by the electrode unit 12 is output to a recording device that is an external device via the wiring pattern 14 and the terminal 16.
  • the recording device records the electrical signal output from the brain electrode 1.
  • the electrode part 12 and the wiring pattern 14 are comprised from the material containing at least any one of gold
  • the bending portion 20 is a flexible portion that extends from one end in the longitudinal direction of the base portion 10 and has a smooth curved surface.
  • the bending portion 20 is engageable with the distal end side of the needle 70 (specifically, the tapered portion 72 of the needle 70 shown in FIG. 3).
  • the bending part 20 has the engagement hole 22 formed so that the taper part 72 of the needle 70 can be engaged.
  • the bending part 20 consists of one base material (specifically, the planar base material 100 shown in FIG. 5A) together with the base 10. Although the details will be described later, the bending portion 20 is formed by bending the tip side of the base material. Thereby, the brain electrode 1 to which the needle 70 can be engaged can be easily manufactured from one component.
  • the bending part 20 has a curved surface formed in an arc shape.
  • the curved surface is an arc-shaped surface having a predetermined curvature as shown in FIG. Due to such a smooth curved surface, it is possible to suppress the cranial nerve tissue from being damaged by the bending portion 20.
  • the curved surface of the bending part 20 is not limited to circular arc shape, For example, you may form in a parabolic shape.
  • the bending part 20 is formed in the hemispherical shape like a ridge.
  • the shape of the bent portion 20 when the bent portion 20 is viewed in plan from the axial direction of the needle 70 (longitudinal direction of the brain electrode 1) is circular like the needle 70, as shown in FIG.
  • a portion in contact with the brain tissue from the distal end portion of the needle 70 to the bent portion 20 continuously forms a smooth surface.
  • the bending portion 20 is formed by bending a circular portion (specifically, a circular portion 120 shown in FIG. 5A) connected to the base portion 10. Although details will be described later, the bowl-shaped bent portion 20 is formed by pressing the circular portion with a spherical processing member and deforming the circular portion along the shape of the processing member.
  • the bending portion 20 has the engagement hole 22 with which the needle 70 can be engaged, but is not limited thereto.
  • the configuration may be such that the engagement hole 22 is not provided, and the bending portion 20 is pushed by the tip of the needle 70 hitting the bending portion 20 or being stuck into the bending portion 20.
  • an electrode unit in which the needle 70 is engaged with the bent portion 20 of the brain electrode 1 as shown in FIG. 3 is prepared.
  • the electrode unit is inserted into the brain from the distal end side of the needle 70 using a jig.
  • the needle 70 of the electrode unit is inserted first, and then the brain electrode 1 is inserted from the bent portion 20 side.
  • the jig may be guided so that the brain electrode 1 is inserted in parallel with the needle 70 so that the brain electrode 1 can be easily inserted.
  • the needle 70 is taken out using a jig or the like while leaving the brain electrode 1 inside the brain.
  • the brain electrode 1 may be used without taking out the needle 70.
  • the brain electrode 1 is used to detect an electrical signal (change in potential) generated by the cranial nerve tissue.
  • the electrode portion 12 of the brain electrode 1 detects a weak electrical signal generated by the cranial nerve tissue that comes into contact, and outputs it to the recording device via the wiring pattern 14 and the terminal 16.
  • the brain electrode 1 can absorb the movement of a cranial nerve tissue by following and bending when the cranial nerve tissue moves, it can suppress that the whole brain electrode 1 moves. Thereby, the brain electrode 1 can continue detection of an electrical signal at a desired position. When the detection by the brain electrode 1 is completed, the brain electrode 1 is taken out using a jig or the like. This completes the work.
  • the brain electrode 1 has a function of detecting an electrical signal generated by the cranial nerve tissue, but is not limited thereto.
  • the brain electrode 1 inserted into the brain may apply an electrical stimulus to treat a disease or the like.
  • FIG. 4 is a flowchart for explaining a method of manufacturing the brain electrode 1.
  • a planar base material having an electrode part is formed (step S102). Specifically, after forming the electrode portion 12 and the wiring pattern 14 on the first layer, the second layer is formed so as to cover the wiring pattern 14, thereby forming the base material (the base shown in FIG. 5A). Material 100) is formed.
  • the first layer and the second layer are made of polyimide, for example, and the electrode portion 12 and the wiring pattern 14 are made of a material containing at least one of gold, platinum, and iridium, for example.
  • FIG. 5 is a diagram for explaining a method of forming the bent portion 20.
  • FIG. 5A shows the planar substrate 100 before forming the bent portion 20.
  • a circular portion 120 is formed on one end side in the longitudinal direction of the substrate 100.
  • the circular portion 120 of the base material 100 is pressed by, for example, a spherical processing member 150 shown in FIG. Then, the circular portion 120 is deformed along the shape of the processed member 150 (see FIG. 5C). At this time, the circular portion 120 may be deformed by applying heat. As a result, the circular portion 120 is deformed into a bowl-shaped bent portion 20.
  • the shape of the processed member 150 is not limited to the shape shown in FIG. 5B, and at least the portion that presses the circular portion 120 may be spherical.
  • the bent portion 20 is pressed by the spherical processed member 150 and formed into a bowl shape, but is not limited thereto.
  • the bending portion 20 may be formed in a shape in which one end side of the base material 100 includes a part of a circumference centering on an axis in a direction orthogonal to the longitudinal direction of the base material 100. That is, the bending part 20 may be formed by bending one end side of the base material 100 into a U shape or a J shape. In this case, the bending part 20 is formed in U shape or J shape by winding the one end side of the base material 100 around the column-shaped processed member 150, for example.
  • the brain electrode 1 that is inserted into the deep part of the brain by being pushed by the needle 70 that is an insertion member extends from one end side of the base 10 and has a flexible bending part 20 having a curved surface.
  • the brain electrode 1 is pushed by the needle 70 that engages with the bending portion 20, thereby reducing the area where the cranial nerve tissue is damaged as compared with the conventional method, and the deep portion in the brain together with the needle 70. Therefore, it is suitable as a minimally invasive brain electrode.
  • the bending part 20 consists of one base material 100 with the base part 10, and the base part 10 and the bending part 20 simplify the brain electrode 1 in which the base part 10 and the bending part 20 have flexibility by forming. Can be manufactured.
  • the bent portion 20 of the brain electrode 1 is formed in a bowl shape. As a result, there is no portion where the bending portion 20 protrudes from the needle 70 in the radial direction of the needle 70, so that it is effective to damage the cranial nerve tissue by the bending portion 20 when the needle 70 is inserted into the brain. Can be suppressed.
  • FIG. 6 is a diagram for explaining the configuration of the brain electrode 200 according to the second embodiment.
  • FIG. 7 is a development view showing the base material 260 before the bending portion 220 of the brain electrode 200 is formed.
  • the brain electrode 200 according to the second embodiment also has a base part 210, an electrode part 212 (FIG. 7), and a bending part 220. Since the configurations of the base 210 and the electrode unit 212 are the same as the configurations of the base 10 and the electrode unit 12 of the first embodiment, detailed description thereof is omitted. Unlike the bending part 20 of 1st Embodiment formed in the hook shape, the bending part 220 is formed in the bending shape as shown in FIG. The shape of the bent portion is arbitrary, and the tip portion may be a shape including a part of a circle or a part of an ellipse.
  • Engagement holes 221 and 222 for engaging the needle 70 are formed in the bending portion 220. Also in the second embodiment, when the needle 70 is inserted into the brain, the bending electrode 220 is pushed by the needle 70 so that the brain electrode 200 is also inserted deep in the brain.
  • a protruding piece 223 that is locked in a locking hole 218 that is a locking portion formed in the base 210 is formed at the tip of the bent portion 220.
  • the protruding piece 223 is allowed to move slightly with respect to the locking hole 218.
  • the bending portion 220 is formed by bending one end portion 270 in the longitudinal direction of the planar substrate 260 shown in FIG. Specifically, the one end portion 270 is bent at the bending position 272 and the projecting piece 223 of the one end portion 270 is locked to the locking hole 218 of the base material 260.
  • the bending position 272 is a portion where the width is narrowed in the base material 260.
  • the engagement hole 222 described above is formed at the bending position 272, and is located at the tip of the brain electrode 200 as shown in FIG. This makes it easier for the brain electrode 200 to follow the needle 70 inserted into the brain.
  • the brain electrode 200 has a flexible bending portion 220 that extends from one end side of the base portion 210 and has a smooth curved surface.
  • the bent portion 220 includes a base material 260 together with the base portion 210, and is formed by bending one end side of the base material 260, whereby the base portion 210 and the bent portion 220 simplify the flexible brain electrode 200. Can be manufactured.
  • the bent portion 220 is formed in a bent shape, but the present invention is not limited to this.
  • the bent portion 220 may be formed in an arc shape or a bowl shape (see FIG. 2 or the like), and the bent portion 220 having such a shape may be locked in the locking hole 218 of the base portion 210. .

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Abstract

A brain electrode (1), which can be inserted into the brain, is provided with the following: a planar base (10); electrodes (12) that are formed in the base (10); and a flexible bending part (20) that extends from one end of the base (10) and has a rounded surface.

Description

脳電極Brain electrode
　本発明は、脳内部に挿入可能な脳電極に関する。 The present invention relates to a brain electrode that can be inserted into the brain.
　近年、病気の治療等のために、脳機能の解明が要請されている。そこで、脳内部に電極（以下、脳電極と呼ぶ）を挿入して、脳神経組織に流れる微弱の電気信号（細胞の活動電位）を測定することが行われている。 Recently, elucidation of brain functions has been requested for the treatment of diseases. In view of this, an electrode (hereinafter referred to as a brain electrode) is inserted into the brain and a weak electrical signal (cell action potential) flowing through the cranial nerve tissue is measured.
　脳電極として、例えば下記の特許文献１には、電極部及び配線部を含む複数の電極配線が、柔軟絶縁材料からなる絶縁層上に設けられた神経電極が開示されている。この神経電極は、脳に刺入された状態で、脳に電気的な刺激を与えたり、脳の電気的な活動を計測したりするために用いられる。 As a brain electrode, for example, Patent Document 1 below discloses a nerve electrode in which a plurality of electrode wirings including an electrode part and a wiring part are provided on an insulating layer made of a flexible insulating material. The nerve electrode is used to give an electrical stimulus to the brain or to measure an electrical activity of the brain while being inserted into the brain.
特開２００９－２８５１５３号公報JP 2009-285153 A
　ところで、脳の様々な活動を正確に解明するためには、脳電極を脳内の深部に挿入することが望ましい。そこで、針等の挿入部材を用いて脳電極を脳内の深部に挿入する方策が検討されている。
　しかし、特許文献１では、神経電極が平板状に形成されているため、挿入部材を用いて神経電極を脳内の深部に挿入することが困難である。一方で、脳電極を挿入部材で脳の内部に挿入させるために脳電極を複雑な構造にした場合には、脳電極を挿入する際に脳神経組織を損傷する恐れがある。 By the way, in order to elucidate various brain activities accurately, it is desirable to insert brain electrodes deep in the brain. Therefore, a method of inserting a brain electrode into a deep part of the brain using an insertion member such as a needle has been studied.
However, in Patent Document 1, since the nerve electrode is formed in a flat plate shape, it is difficult to insert the nerve electrode deep into the brain using the insertion member. On the other hand, if the brain electrode has a complicated structure in order to insert the brain electrode into the brain with the insertion member, there is a risk of damaging the cranial nerve tissue when the brain electrode is inserted.
　そこで、本発明はこれらの点に鑑みてなされたものであり、挿入部材によって脳内の深部に適切に挿入可能な簡易構造の脳電極を提供することを目的とする。 Therefore, the present invention has been made in view of these points, and an object thereof is to provide a brain electrode having a simple structure that can be appropriately inserted into a deep part of the brain by an insertion member.
　本発明の第１の態様においては、脳内部に挿入可能な脳電極であって、平面状の基部と、前記基部に形成された電極部と、前記基部の一端側から延出し、曲面を有する柔軟な曲げ部と、を備える脳電極を提供する。 The first aspect of the present invention is a brain electrode that can be inserted into the brain, and has a planar base, an electrode formed on the base, and a curved surface that extends from one end of the base. A brain electrode including a flexible bending portion is provided.
　また、前記曲げ部は、円弧状に形成された前記曲面を有することとしてもよい。
　また、前記曲げ部は、椀状に形成されていることとしてもよい。 Moreover, the said bending part is good also as having the said curved surface formed in circular arc shape.
The bent portion may be formed in a bowl shape.
　また、前記曲げ部は、折り曲げ形状に形成されており、前記基部は、折り曲げ形状の前記曲げ部の先端側が係止する係止部を有することとしてもよい。 Further, the bent portion may be formed in a bent shape, and the base portion may have a locking portion that is locked to a distal end side of the bent portion of the bent shape.
　また、前記曲げ部は、前記脳電極を前記脳内部に挿入する挿入部材の先端側が係合可能な係合穴を有することとしてもよい。 Further, the bent portion may have an engagement hole in which a distal end side of an insertion member for inserting the brain electrode into the brain can be engaged.
　本発明によれば、挿入部材によって脳内の深部に適切に挿入可能な簡易構造の脳電極を提供できるという効果を奏する。 According to the present invention, it is possible to provide a brain electrode having a simple structure that can be appropriately inserted into the deep part of the brain by the insertion member.
本発明の第１の実施形態に係る脳電極１の構成を示す概略平面図である。1 is a schematic plan view showing a configuration of a brain electrode 1 according to a first embodiment of the present invention. 脳電極１の構成を示す概略断面図である。1 is a schematic cross-sectional view showing a configuration of a brain electrode 1. 脳電極１の使用形態を説明するための模式図である。It is a schematic diagram for demonstrating the usage form of the brain electrode. 脳電極１の製造方法を説明するためのフローチャートである。4 is a flowchart for explaining a method of manufacturing the brain electrode 1. 曲げ部２０の形成方法を説明するための図である。It is a figure for demonstrating the formation method of the bending part. 第２の実施形態に係る脳電極２００の構成を説明するための図である。It is a figure for demonstrating the structure of the brain electrode 200 which concerns on 2nd Embodiment. 脳電極２００の曲げ部２２０を形成する前の基材２６０を示す展開図であるFIG. 4 is a development view showing a base material 260 before forming a bent portion 220 of a brain electrode 200.
　＜第１の実施形態＞
　（脳電極の構成）
　図１～図３を参照しながら、本発明の第１の実施形態に係る脳電極１の構成について説明する。 <First Embodiment>
(Configuration of brain electrode)
The configuration of the brain electrode 1 according to the first embodiment of the present invention will be described with reference to FIGS.
　図１は、第１の実施形態に係る脳電極１の構成を示す概略平面図である。図２は、脳電極１の構成を示す概略断面図である。図３は、脳電極１の使用形態を説明するための模式図である。 FIG. 1 is a schematic plan view showing the configuration of the brain electrode 1 according to the first embodiment. FIG. 2 is a schematic cross-sectional view showing the configuration of the brain electrode 1. FIG. 3 is a schematic diagram for explaining a usage pattern of the brain electrode 1.
　脳電極１は、脳内の深部に挿入可能な電極であり、脳の様々な活動を解明するためのものである。脳電極１は、挿入部材によって脳内部に挿入させる。例えば、脳電極１は、脳内部に刺入される針７０（図３）に押されて、針７０と共に脳内部に挿入される。挿入部材としては、針７０に限定されず、例えば光ファイバーや細い管であってもよい。なお、脳電極１は、挿入部材を用いることなく、脳電極１を押すことにより脳内部に挿入されてもよい。 The brain electrode 1 is an electrode that can be inserted deep in the brain and is used to elucidate various activities of the brain. The brain electrode 1 is inserted into the brain by an insertion member. For example, the brain electrode 1 is pushed by a needle 70 (FIG. 3) inserted into the brain and inserted into the brain together with the needle 70. The insertion member is not limited to the needle 70, and may be, for example, an optical fiber or a thin tube. The brain electrode 1 may be inserted into the brain by pressing the brain electrode 1 without using an insertion member.
　脳電極１は、ここでは例えば１０～１００（ｍｍ）挿入されるが、１００（ｍｍ）以上挿入されてもよい。脳電極１は、脳内部に挿入された状態で、脳神経組織の活動を示す電気信号を検出する。脳電極１は、図１及び図２に示すように、基部１０と、電極部１２と、曲げ部２０とを有する。 The brain electrode 1 is inserted here, for example, 10 to 100 (mm), but may be inserted 100 (mm) or more. The brain electrode 1 detects an electrical signal indicating the activity of the cranial nerve tissue while being inserted into the brain. As shown in FIGS. 1 and 2, the brain electrode 1 includes a base portion 10, an electrode portion 12, and a bending portion 20.
　基部１０は、平面状の部分である。基部１０は、例えばポリイミドを積層（具体的には２層）した構造から成る。また、基部１０は、厚さが例えば２０（μｍ）と薄く形成されており、可撓性を有する。かかる場合には、脳内部に挿入された脳電極１は、柔らかい脳神経組織の動きに追従して撓むことが可能となる。この結果、脳電極１全体が脳内部で移動することで検出位置が、脳神経組織に対して相対的に変位することを抑制でき、また脳電極１が折れることを抑制できる。 The base 10 is a planar part. The base 10 has a structure in which, for example, polyimide is laminated (specifically, two layers). Further, the base 10 is formed to be as thin as 20 (μm), for example, and has flexibility. In such a case, the brain electrode 1 inserted into the brain can bend following the movement of the soft cranial nerve tissue. As a result, it is possible to suppress the displacement of the detection position relative to the cranial nerve tissue by moving the entire brain electrode 1 within the brain, and it is possible to suppress the brain electrode 1 from breaking.
　なお、図２では基部１０全体が均一な厚みの平面として示されているが、これに限定されない。例えば、基部１０は、一部に凹凸部分を有してもよい。また、基部１０の厚みが、不均一であってもよい。 In addition, in FIG. 2, although the whole base 10 is shown as a plane of uniform thickness, it is not limited to this. For example, the base 10 may have an uneven portion in part. Further, the thickness of the base 10 may be non-uniform.
　電極部１２は、基部１０から露出するように形成されている。図１において、３個の電極部１２が示されているが、電極部１２の数は任意である。電極部１２は、脳神経組織と接触できるように、基部１０の両面の少なくとも一方の面から露出している。電極部１２は、脳電極１が脳内部に挿入された状態で脳神経組織に接触して、脳神経組織が発生する電気信号（例えば、電位の変化）を検出する。 The electrode part 12 is formed so as to be exposed from the base part 10. In FIG. 1, three electrode portions 12 are shown, but the number of electrode portions 12 is arbitrary. The electrode part 12 is exposed from at least one surface of both surfaces of the base 10 so that it can contact with a cranial nerve tissue. The electrode unit 12 is in contact with the cranial nerve tissue in a state where the brain electrode 1 is inserted into the brain, and detects an electrical signal (for example, a potential change) generated by the cranial nerve tissue.
　電極部１２は、基部１０内に形成された配線パターン１４と接続されている。配線パターン１４は、外部装置と接続可能な端子１６と接続されている。電極部１２が検出した電気信号は、配線パターン１４及び端子１６を介して、外部装置である記録装置に出力される。記録装置は、脳電極１から出力された電気信号を記録する。
　なお、電極部１２及び配線パターン１４は、例えば金、白金及びイリジウムの少なくともいずれか一つを含む材料から構成される。 The electrode part 12 is connected to a wiring pattern 14 formed in the base part 10. The wiring pattern 14 is connected to a terminal 16 that can be connected to an external device. The electrical signal detected by the electrode unit 12 is output to a recording device that is an external device via the wiring pattern 14 and the terminal 16. The recording device records the electrical signal output from the brain electrode 1.
In addition, the electrode part 12 and the wiring pattern 14 are comprised from the material containing at least any one of gold | metal | money, platinum, and iridium, for example.
　曲げ部２０は、基部１０の長手方向一端側から延出し、滑らかな曲面を有する柔軟な部位である。曲げ部２０には、針７０の先端側（具体的には、図３に示す針７０のテーパー部７２）が係合可能である。曲げ部２０は、針７０のテーパー部７２が係合可能に形成された係合穴２２を有する。これにより、針７０を脳内部に刺入する際に曲げ部２０が針に押されて、脳電極１も脳内部に挿入される。 The bending portion 20 is a flexible portion that extends from one end in the longitudinal direction of the base portion 10 and has a smooth curved surface. The bending portion 20 is engageable with the distal end side of the needle 70 (specifically, the tapered portion 72 of the needle 70 shown in FIG. 3). The bending part 20 has the engagement hole 22 formed so that the taper part 72 of the needle 70 can be engaged. As a result, when the needle 70 is inserted into the brain, the bending portion 20 is pushed by the needle, and the brain electrode 1 is also inserted into the brain.
　曲げ部２０は、基部１０と共に一つの基材（具体的には、図５（ａ）に示す平面状の基材１００）から成る。詳細は後述するが、曲げ部２０は、基材の先端側を曲げて形成されている。これにより、針７０が係合可能な脳電極１を一部品から簡易に製造可能となる。 The bending part 20 consists of one base material (specifically, the planar base material 100 shown in FIG. 5A) together with the base 10. Although the details will be described later, the bending portion 20 is formed by bending the tip side of the base material. Thereby, the brain electrode 1 to which the needle 70 can be engaged can be easily manufactured from one component.
　曲げ部２０は、円弧状に形成された曲面を有する。第１の実施形態では、曲面は、図２に示すように所定曲率の円弧状の面となっている。このような滑らかな曲面となっていることで、曲げ部２０によって脳神経組織を損傷することを抑制できる。なお、曲げ部２０の曲面は、円弧状に限定されず、例えば放物線状に形成されてもよい。 The bending part 20 has a curved surface formed in an arc shape. In the first embodiment, the curved surface is an arc-shaped surface having a predetermined curvature as shown in FIG. Due to such a smooth curved surface, it is possible to suppress the cranial nerve tissue from being damaged by the bending portion 20. In addition, the curved surface of the bending part 20 is not limited to circular arc shape, For example, you may form in a parabolic shape.
　また、曲げ部２０は、椀のような半球形状に形成されている。かかる場合には、針７０の軸方向（脳電極１の長手方向）から曲げ部２０を平面視した場合の曲げ部２０の形状は、針７０と同様に円形状となり、図３に示すように針７０の先端部から曲げ部２０にかけて脳組織と接する部分は連続的に滑らかな表面を形成する。これにより、針７０が脳内部に刺入される際に、曲げ部２０によって脳神経組織が損傷することを抑制できる。 Moreover, the bending part 20 is formed in the hemispherical shape like a ridge. In such a case, the shape of the bent portion 20 when the bent portion 20 is viewed in plan from the axial direction of the needle 70 (longitudinal direction of the brain electrode 1) is circular like the needle 70, as shown in FIG. A portion in contact with the brain tissue from the distal end portion of the needle 70 to the bent portion 20 continuously forms a smooth surface. Thereby, when the needle 70 is inserted into the inside of the brain, the cranial nerve tissue can be prevented from being damaged by the bending portion 20.
　曲げ部２０は、基部１０と繋がった円形部分（具体的には、図５（ａ）に示す円形部分１２０）を曲げて形成されている。詳細は後述するが、円形部分を球状の加工部材で押圧して加工部材の形状に沿うように変形させることで、椀状の曲げ部２０が形成される。 The bending portion 20 is formed by bending a circular portion (specifically, a circular portion 120 shown in FIG. 5A) connected to the base portion 10. Although details will be described later, the bowl-shaped bent portion 20 is formed by pressing the circular portion with a spherical processing member and deforming the circular portion along the shape of the processing member.
　なお、上記では、曲げ部２０は、針７０が係合可能な係合穴２２を有することとしたが、これに限定されない。例えば係合穴２２を設けず、針７０の先端が曲げ部２０に当たることにより、又は曲げ部２０に刺さることにより、曲げ部２０を押す構成であってもよい。 In the above description, the bending portion 20 has the engagement hole 22 with which the needle 70 can be engaged, but is not limited thereto. For example, the configuration may be such that the engagement hole 22 is not provided, and the bending portion 20 is pushed by the tip of the needle 70 hitting the bending portion 20 or being stuck into the bending portion 20.
　（脳電極の使用例）
　上述した構成の脳電極１の具体的な使用例について説明する。
　まず、図３に示すように針７０が脳電極１の曲げ部２０に係合した状態のユニット（以下、電極ユニットと呼ぶ）を準備する。 (Usage example of brain electrode)
A specific usage example of the brain electrode 1 having the above-described configuration will be described.
First, a unit (hereinafter referred to as an electrode unit) in which the needle 70 is engaged with the bent portion 20 of the brain electrode 1 as shown in FIG. 3 is prepared.
　次に、治具を用いて、電極ユニットを針７０の先端側から脳内部に挿入する。この際、電極ユニットの針７０が先に挿入され、続いて脳電極１は曲げ部２０側から挿入される。なお、治具は、脳電極１が挿入されやすいように、脳電極１が針７０と平行に挿入されるようにガイドしてもよい。 Next, the electrode unit is inserted into the brain from the distal end side of the needle 70 using a jig. At this time, the needle 70 of the electrode unit is inserted first, and then the brain electrode 1 is inserted from the bent portion 20 side. The jig may be guided so that the brain electrode 1 is inserted in parallel with the needle 70 so that the brain electrode 1 can be easily inserted.
　電極ユニットが脳内の深部に挿入されると、脳電極１を脳内部に残した状態で、冶具等を用いて針７０を取り出す。なお、針７０を取り出すことなく脳電極１を使用してもよい。
　次に、脳電極１を用いて、脳神経組織が発生する電気信号（電位の変化）を検出する。具体的には、脳電極１の電極部１２が、接触する脳神経組織が発生する微弱の電気信号を検出し、配線パターン１４及び端子１６を介して記録装置に出力する。 When the electrode unit is inserted deep in the brain, the needle 70 is taken out using a jig or the like while leaving the brain electrode 1 inside the brain. The brain electrode 1 may be used without taking out the needle 70.
Next, the brain electrode 1 is used to detect an electrical signal (change in potential) generated by the cranial nerve tissue. Specifically, the electrode portion 12 of the brain electrode 1 detects a weak electrical signal generated by the cranial nerve tissue that comes into contact, and outputs it to the recording device via the wiring pattern 14 and the terminal 16.
　なお、脳電極１は、脳神経組織が動いた際に追従して撓むことで、脳神経組織の動きを吸収できるので、脳電極１全体が移動してしまうことを抑制できる。これにより、脳電極１は、所望の位置にて電気信号の検出を継続できる。
　脳電極１による検出が完了すると、冶具等を用いて脳電極１を取り出す。これにより、作業が完了する。 In addition, since the brain electrode 1 can absorb the movement of a cranial nerve tissue by following and bending when the cranial nerve tissue moves, it can suppress that the whole brain electrode 1 moves. Thereby, the brain electrode 1 can continue detection of an electrical signal at a desired position.
When the detection by the brain electrode 1 is completed, the brain electrode 1 is taken out using a jig or the like. This completes the work.
　なお、上記では、脳電極１は、脳神経組織が発生する電気信号を検出する機能を有することとしたが、これに限定されない。例えば、脳内部に挿入された脳電極１が電気的な刺激を付与することで、病気等を治療してもよい。また、脳電極１が電気的な刺激を付与することで、例えば義手・義足の動きを制御してもよい。 In the above description, the brain electrode 1 has a function of detecting an electrical signal generated by the cranial nerve tissue, but is not limited thereto. For example, the brain electrode 1 inserted into the brain may apply an electrical stimulus to treat a disease or the like. Moreover, you may control the motion of an artificial hand and a prosthetic leg, for example by giving the brain electrode 1 electrical stimulation.
　（脳電極の製造方法）
　図４を参照しながら、第１の実施形態に係る脳電極１の製造方法について説明する。
　図４は、脳電極１の製造方法を説明するためのフローチャートである。 (Method for manufacturing brain electrode)
A method for manufacturing the brain electrode 1 according to the first embodiment will be described with reference to FIG.
FIG. 4 is a flowchart for explaining a method of manufacturing the brain electrode 1.
　まず、電極部を有する平面状の基材を形成する（ステップＳ１０２）。具体的には、第１層の上に電極部１２及び配線パターン１４を形成した後に、配線パターン１４を覆うように第２層を形成することで、基材（図５（ａ）に示す基材１００）が形成される。なお、第１層及び第２層は、例えばポリイミドから成り、電極部１２及び配線パターン１４は、例えば金、白金及びイリジウムの少なくともいずれか一つを含む材料から成る。 First, a planar base material having an electrode part is formed (step S102). Specifically, after forming the electrode portion 12 and the wiring pattern 14 on the first layer, the second layer is formed so as to cover the wiring pattern 14, thereby forming the base material (the base shown in FIG. 5A). Material 100) is formed. The first layer and the second layer are made of polyimide, for example, and the electrode portion 12 and the wiring pattern 14 are made of a material containing at least one of gold, platinum, and iridium, for example.
　次に、基材の一端側を曲げて曲げ部２０を形成する（ステップＳ１０４）。図５を参照しながら、曲げ部２０の形成方法について説明する。
　図５は、曲げ部２０の形成方法を説明するための図である。図５（ａ）は、曲げ部２０を形成する前の平面状の基材１００を示す。基材１００の長手方向一端側には、円形部分１２０が形成されている。 Next, the bending part 20 is formed by bending one end side of the base material (step S104). A method for forming the bent portion 20 will be described with reference to FIG.
FIG. 5 is a diagram for explaining a method of forming the bent portion 20. FIG. 5A shows the planar substrate 100 before forming the bent portion 20. A circular portion 120 is formed on one end side in the longitudinal direction of the substrate 100.
　本実施形態では、基材１００の円形部分１２０を、例えば図５（ｂ）に示す球状の加工部材１５０で押圧する。すると、円形部分１２０が加工部材１５０の形状に沿って変形する（図５（ｃ）参照）。この際、円形部分１２０に熱を加えて変形させてもよい。これにより、円形部分１２０が、椀形状の曲げ部２０に変形する。なお、加工部材１５０の形状は、図５（ｂ）に示す形状に限定されず、少なくとも円形部分１２０を押圧する部位が球状であればよい。 In the present embodiment, the circular portion 120 of the base material 100 is pressed by, for example, a spherical processing member 150 shown in FIG. Then, the circular portion 120 is deformed along the shape of the processed member 150 (see FIG. 5C). At this time, the circular portion 120 may be deformed by applying heat. As a result, the circular portion 120 is deformed into a bowl-shaped bent portion 20. Note that the shape of the processed member 150 is not limited to the shape shown in FIG. 5B, and at least the portion that presses the circular portion 120 may be spherical.
　なお、上記では、曲げ部２０が球状の加工部材１５０で押圧して椀形状に形成されていることとしたが、これに限定されない。例えば、曲げ部２０は、基材１００の一端側が、基材１００の長手方向に対して直交する方向の軸を中心とする円周の一部を含む形状に形成されていてもよい。すなわち、曲げ部２０は、基材１００の一端側をＵ字状又はＪ字状に曲げて形成されていてもよい。この場合、曲げ部２０は、例えば、基材１００の一端側を円柱状の加工部材１５０に巻きつけることにより、Ｕ字状又はＪ字状に形成される。 In the above description, the bent portion 20 is pressed by the spherical processed member 150 and formed into a bowl shape, but is not limited thereto. For example, the bending portion 20 may be formed in a shape in which one end side of the base material 100 includes a part of a circumference centering on an axis in a direction orthogonal to the longitudinal direction of the base material 100. That is, the bending part 20 may be formed by bending one end side of the base material 100 into a U shape or a J shape. In this case, the bending part 20 is formed in U shape or J shape by winding the one end side of the base material 100 around the column-shaped processed member 150, for example.
　（第１の実施形態における効果）
　上述した第１の実施形態において、挿入部材である針７０に押されて脳内の深部に挿入される脳電極１は、基部１０の一端側から延出し、曲面を有する柔軟な曲げ部２０を有する。かかる場合には、脳電極１は、曲げ部２０に係合する針７０によって押されることで、従来の方法に比べて脳神経組織が損傷される領域を低減させつつ、針７０と共に脳内の深部に挿入されやすくなるので、低侵襲性の脳電極として好適である。また、曲げ部２０は基部１０と共に一つの基材１００から成り、基材１００の一端側を曲げて形成されることで、基部１０及び曲げ部２０が可撓性を有する脳電極１を簡易に製造できる。 (Effect in the first embodiment)
In the first embodiment described above, the brain electrode 1 that is inserted into the deep part of the brain by being pushed by the needle 70 that is an insertion member extends from one end side of the base 10 and has a flexible bending part 20 having a curved surface. Have. In such a case, the brain electrode 1 is pushed by the needle 70 that engages with the bending portion 20, thereby reducing the area where the cranial nerve tissue is damaged as compared with the conventional method, and the deep portion in the brain together with the needle 70. Therefore, it is suitable as a minimally invasive brain electrode. Moreover, the bending part 20 consists of one base material 100 with the base part 10, and the base part 10 and the bending part 20 simplify the brain electrode 1 in which the base part 10 and the bending part 20 have flexibility by forming. Can be manufactured.
　また、第１の実施形態では、脳電極１の曲げ部２０が椀形状に形成されている。これにより、針７０の半径方向において曲げ部２０が針７０よりも突出する部分がなくなるので、針７０が脳内部の刺入される際に、曲げ部２０によって脳神経組織が損傷することを効果的に抑制できる。 In the first embodiment, the bent portion 20 of the brain electrode 1 is formed in a bowl shape. As a result, there is no portion where the bending portion 20 protrudes from the needle 70 in the radial direction of the needle 70, so that it is effective to damage the cranial nerve tissue by the bending portion 20 when the needle 70 is inserted into the brain. Can be suppressed.
　＜第２の実施形態＞
　図６及び図７を参照しながら、第２の実施形態に係る脳電極２００について説明する。
　図６は、第２の実施形態に係る脳電極２００の構成を説明するための図である。図７は、脳電極２００の曲げ部２２０を形成する前の基材２６０を示す展開図である。 <Second Embodiment>
A brain electrode 200 according to the second embodiment will be described with reference to FIGS. 6 and 7.
FIG. 6 is a diagram for explaining the configuration of the brain electrode 200 according to the second embodiment. FIG. 7 is a development view showing the base material 260 before the bending portion 220 of the brain electrode 200 is formed.
　第２の実施形態に係る脳電極２００も、基部２１０と、電極部２１２（図７）と、曲げ部２２０とを有する。基部２１０及び電極部２１２の構成は、第１の実施形態の基部１０及び電極部１２の構成と同様なので、詳細な説明は省略する。曲げ部２２０は、椀形状に形成された第１の実施形態の曲げ部２０とは異なり、図６に示すように折り曲げ形状に形成されている。折り曲げられた部分の形状は任意であり、先端部が円の一部、又は楕円の一部を含む形状であってもよい。 The brain electrode 200 according to the second embodiment also has a base part 210, an electrode part 212 (FIG. 7), and a bending part 220. Since the configurations of the base 210 and the electrode unit 212 are the same as the configurations of the base 10 and the electrode unit 12 of the first embodiment, detailed description thereof is omitted. Unlike the bending part 20 of 1st Embodiment formed in the hook shape, the bending part 220 is formed in the bending shape as shown in FIG. The shape of the bent portion is arbitrary, and the tip portion may be a shape including a part of a circle or a part of an ellipse.
　曲げ部２２０には、針７０を係合させるための係合穴２２１、２２２が形成されている。第２の実施形態でも、針７０が脳内部に刺入される際に、曲げ部２２０が針７０に押されることで脳電極２００も脳内の深部に挿入される。 Engagement holes 221 and 222 for engaging the needle 70 are formed in the bending portion 220. Also in the second embodiment, when the needle 70 is inserted into the brain, the bending electrode 220 is pushed by the needle 70 so that the brain electrode 200 is also inserted deep in the brain.
　また、曲げ部２２０の先端には、基部２１０に形成された係止部である係止穴２１８に係止されている突片２２３が形成されている。なお、突片２２３は、係止穴２１８に対して若干の移動が許容されている。 Also, a protruding piece 223 that is locked in a locking hole 218 that is a locking portion formed in the base 210 is formed at the tip of the bent portion 220. The protruding piece 223 is allowed to move slightly with respect to the locking hole 218.
　曲げ部２２０は、図７に示す平面状の基材２６０の長手方向の一端部２７０を折り曲げることで、形成されている。具体的には、一端部２７０を折り曲げ位置２７２で折り曲げて、一端部２７０の突片２２３を基材２６０の係止穴２１８に係止させることで、形成されている。折り曲げ位置２７２は、基材２６０において幅が狭くなっている部分である。
　なお、前述した係合穴２２２は、折り曲げ位置２７２に形成されており、図６に示すように脳電極２００の先端に位置する。これにより、脳電極２００が、脳内部に刺入される針７０に追従しやすくなる。 The bending portion 220 is formed by bending one end portion 270 in the longitudinal direction of the planar substrate 260 shown in FIG. Specifically, the one end portion 270 is bent at the bending position 272 and the projecting piece 223 of the one end portion 270 is locked to the locking hole 218 of the base material 260. The bending position 272 is a portion where the width is narrowed in the base material 260.
The engagement hole 222 described above is formed at the bending position 272, and is located at the tip of the brain electrode 200 as shown in FIG. This makes it easier for the brain electrode 200 to follow the needle 70 inserted into the brain.
　第２の実施形態においても、脳電極２００は、基部２１０の一端側から延出し、滑らかな曲面を有する柔軟な曲げ部２２０を有する。これにより、針７０が脳内部に刺入される際に曲げ部２２０が押されて挿入されることで、脳電極２００を脳内の深部に挿入しやすくなる。また、曲げ部２２０は、基部２１０と共に一つの基材２６０から成り、基材２６０の一端側を曲げて形成されることで、基部２１０及び曲げ部２２０が可撓性を有する脳電極２００を簡易に製造できる。 Also in the second embodiment, the brain electrode 200 has a flexible bending portion 220 that extends from one end side of the base portion 210 and has a smooth curved surface. Thus, when the needle 70 is inserted into the brain, the bending portion 220 is pushed and inserted, so that the brain electrode 200 can be easily inserted into the deep portion of the brain. The bent portion 220 includes a base material 260 together with the base portion 210, and is formed by bending one end side of the base material 260, whereby the base portion 210 and the bent portion 220 simplify the flexible brain electrode 200. Can be manufactured.
　なお、上記では、曲げ部２２０が折り曲げ形状に形成されていることとしたが、これに限定されない。例えば、曲げ部２２０が、円弧状や椀状（図２等参照）に形成されてよく、かかる形状の曲げ部２２０が、基部２１０の係止穴２１８に係止される構成であってもよい。 In the above description, the bent portion 220 is formed in a bent shape, but the present invention is not limited to this. For example, the bent portion 220 may be formed in an arc shape or a bowl shape (see FIG. 2 or the like), and the bent portion 220 having such a shape may be locked in the locking hole 218 of the base portion 210. .
　以上、本発明を実施の形態を用いて説明したが、本発明の技術的範囲は上記実施の形態に記載の範囲には限定されない。上記実施の形態に、多様な変更又は改良を加えることが可能であることが当業者に明らかである。そのような変更又は改良を加えた形態も本発明の技術的範囲に含まれ得ることが、特許請求の範囲の記載から明らかである。 As mentioned above, although this invention was demonstrated using embodiment, the technical scope of this invention is not limited to the range as described in the said embodiment. It will be apparent to those skilled in the art that various modifications or improvements can be added to the above embodiment. It is apparent from the scope of the claims that the embodiments added with such changes or improvements can be included in the technical scope of the present invention.
　１　　脳電極
　１０　　基部
　１２　　電極部
　２０　　曲げ部
　２２　　係合穴
　７０　　針
　１００　　基材
　１２０　　円形部分
　２００　　脳電極
　２１０　　基部
　２１８　　係止穴
　２１２　　電極部
　２２０　　曲げ部 DESCRIPTION OF SYMBOLS 1 Brain electrode 10 Base 12 Electrode part 20 Bending part 22 Engagement hole 70 Needle 100 Base material 120 Circular part 200 Brain electrode 210 Base part 218 Locking hole 212 Electrode part 220 Bending part

Claims (5)

  1. 　脳内部に挿入可能な脳電極であって、
    　平面状の基部と、
    　前記基部に形成された電極部と、
    　前記基部の一端側から延出し、曲面を有する柔軟な曲げ部と、
    　を備える脳電極。     A brain electrode that can be inserted into the brain,
    A planar base;
    An electrode portion formed on the base;
    A flexible bend extending from one end of the base and having a curved surface;
    A brain electrode comprising:
  2. 　前記曲げ部は、円弧状に形成された前記曲面を有する、
    　請求項１に記載の脳電極。     The bent portion has the curved surface formed in an arc shape.
    The brain electrode according to claim 1.
  3. 　前記曲げ部は、椀状に形成されている、
    　請求項１又は２に記載の脳電極。     The bent portion is formed in a bowl shape.
    The brain electrode according to claim 1 or 2.
  4. 　前記曲げ部は、折り曲げ形状に形成されており、
    　前記基部は、折り曲げ形状の前記曲げ部の先端側が係止する係止部を有する、
    　請求項１に記載の脳電極。     The bent portion is formed in a bent shape,
    The base portion has a locking portion that is locked to the distal end side of the bent portion of the bent shape.
    The brain electrode according to claim 1.
  5. 　前記曲げ部は、前記脳電極を前記脳内部に挿入する挿入部材の先端側が係合可能な係合穴を有する、
    　請求項１から４のいずれか１項に記載の脳電極。
     
     
          The bending portion has an engagement hole with which a distal end side of an insertion member for inserting the brain electrode into the brain can be engaged,
    The brain electrode according to any one of claims 1 to 4.


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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022501161A (en) * 2018-09-14 2022-01-06 ニューラリンク コーポレーションNeuralink Corp. Electrode fabrication and design
US11925800B2 (en) 2018-09-14 2024-03-12 Neuralink, Inc. Device implantation using a cartridge

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009285154A (en) * 2008-05-29 2009-12-10 Nippon Telegr & Teleph Corp <Ntt> Peripheral nerve type flexible nerve electrode and its manufacturing method
US20130123599A1 (en) * 2011-11-11 2013-05-16 Korea Institute Of Science And Technology Micro probe and manufacturing method thereof
JP2013543743A (en) * 2010-10-21 2013-12-09 エム．アイ．・テク・カンパニー，リミテッド Liquid crystal polymer based electro-optrode neural interface and method of manufacturing the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009285154A (en) * 2008-05-29 2009-12-10 Nippon Telegr & Teleph Corp <Ntt> Peripheral nerve type flexible nerve electrode and its manufacturing method
JP2013543743A (en) * 2010-10-21 2013-12-09 エム．アイ．・テク・カンパニー，リミテッド Liquid crystal polymer based electro-optrode neural interface and method of manufacturing the same
US20130123599A1 (en) * 2011-11-11 2013-05-16 Korea Institute Of Science And Technology Micro probe and manufacturing method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022501161A (en) * 2018-09-14 2022-01-06 ニューラリンク コーポレーションNeuralink Corp. Electrode fabrication and design
EP3849655A4 (en) * 2018-09-14 2022-07-27 Neuralink Corp. Electrode fabrication and design
US11925800B2 (en) 2018-09-14 2024-03-12 Neuralink, Inc. Device implantation using a cartridge

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