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WO2016033898A1 - 一种含有生物抑菌剂的香体沐浴露 - Google Patents

一种含有生物抑菌剂的香体沐浴露 Download PDF

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Publication number
WO2016033898A1
WO2016033898A1 PCT/CN2014/093561 CN2014093561W WO2016033898A1 WO 2016033898 A1 WO2016033898 A1 WO 2016033898A1 CN 2014093561 W CN2014093561 W CN 2014093561W WO 2016033898 A1 WO2016033898 A1 WO 2016033898A1
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Prior art keywords
weight
shower gel
agent
essential oil
composition
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PCT/CN2014/093561
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English (en)
French (fr)
Inventor
谷志静
周生
吴景勉
李洪波
赵泽华
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拉芳家化股份有限公司
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Publication of WO2016033898A1 publication Critical patent/WO2016033898A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Definitions

  • the invention relates to a body shower gel, in particular to a body shower gel containing a biobacterial agent.
  • the stinking smell also known as body odor and odor
  • the fatty acids are higher than ordinary people, and are pale yellow and thick. Sweat itself is tasteless, but the skin is the place where natural bacteria live.
  • the market's body lotion products include emulsions, sprays, balls and glue sticks, but the basic formula consists of similar main functional ingredients for antibacterial agents, auxiliary additives for adding fragrances, skin conditioners, and different properties. And a carrier component that enables it to be effectively applied to the skin.
  • Antibacterial agents kill bacteria and slow their growth.
  • the aluminum salts in antiperspirants are natural antibacterial agents, so they also kill bacteria on the skin, but interfere with human metabolism and should not be used frequently.
  • Various high-performance deodorants without aluminum salts have been reported.
  • the agent relies on specially developed antibacterial agents such as triclosan or polyhexamethylene biguanide.
  • This chemically synthesized antibacterial agent has a broad-spectrum antibacterial effect, and it also causes bacterial resistance and skin residual irritation, causing skin irritation; current studies have shown that triclosan and triclocarban may interfere with human hormones, The United States has drafted a bill to ban antibacterial soaps and baths containing such antibacterial agents. Dew entity sales. For consumers, safety is of course the first consideration. Therefore, the development of safer and more efficient bacteriostatic agents has become a potential consumer demand.
  • Oligofructose is a natural active substance. The Ministry of Health announced (No. 16 of 2008) that oligofructose has been approved as a cosmetic raw material for inhibiting the growth of harmful bacteria on the skin and has a skin health effect.
  • CN1562049A describes the use of oligofructose in the preparation of medicine for treating and preventing vaginitis, promoting the growth of probiotics such as lactobacilli and bifidobacteria to improve the vaginal microenvironment of women and inhibit pathogenic bacteria.
  • the present invention develops a composite antibacterial body shower gel by adding a lactic acid bacteria-oligofructose bio-inhibitor and a Chinese herbal antibacterial aromatic oil to a body lotion.
  • a body shower gel containing a biobacterial agent comprising:
  • a composite surfactant comprising from 7.0% to 35.0% by weight of the composition
  • a skin conditioning agent comprising from 1.0% to 5.0% by weight of the composition
  • a viscosity modifier comprising from 0.1% to 2.0% by weight of the composition
  • a pearlescent agent in an amount of from 0.0% to 3.5% by weight of the composition
  • a chelating agent in an amount of from 0.05% to 0.2% by weight of the composition
  • It is characterized in that it further comprises 1.0%-5.0% of the total weight of the shower gel biocide and 0.5%-5.0% of the total weight of the compound slow-release essential oil;
  • the biobacterial agent is a lactic acid bacteria fermentation extract and a oligofructose compound, and the weight ratio thereof is 1:5-10:1;
  • the compound slow-release essential oil is prepared by adding black pepper essential oil and grapefruit peel oil and ether-modified cyclodextrin in a weight ratio of 2:1:12-1:2:27;
  • Deionized water is used to make up the content of each component of the shower gel when it is less than 100%.
  • the composite surfactant of the present invention is a combination of lauryl sulfate, lauryl polyoxyethylene ether sulfate and a combination of C8-C14 alkyl glycoside, cocamidopropyl betaine and sodium amphoteric acetate.
  • the skin conditioning agent is 1.0% to 5.0% trehalose and 0-1.0% polyquaternium-39; the viscosity modifier is one of hydroxyethyl cellulose and an inorganic salt;
  • the pearling agent is one of ethylene glycol distearate and ethylene glycol monostearate; the chelating agent is disodium edetate.
  • the body shower of the present invention has a pH of less than 7.0, preferably a pH of from 5.0 to 6.5.
  • the oligofructose of the present invention is a mixture of 25%-45% tripolyfructose, 25%-45% tetrameric fructose, 5%-10% pentasaccharide and 0-5% by weight sucrose. .
  • the lactic acid bacteria of the present invention are any combination of Lactobacillus and Lactococcus and Streptococcus lactis.
  • the ether-modified cyclodextrin of the present invention is any combination of hydroxyethyl- ⁇ -cyclodextrin and hydroxypropyl ⁇ -cyclodextrin.
  • the beneficial effects of the invention are: the addition of the biosuppressant not only does not have the irritating effect of the chemical bacteriostatic agent, but also can bring moisturizing feeling to the skin, and more importantly, inhibit the growth of pathogenic bacteria causing sweat odor and promote the production of antibiotics.
  • the growth of beneficial bacteria can regulate skin micro-ecology and improve body odor.
  • the skin conditioner alginate
  • the trehalose has the effect of inhibiting the body odor of the middle-aged and elderly people.
  • the slow-release preparation of the black pepper essential oil and the grapefruit essential oil not only has the aromatic long-lasting property but also can constitute a natural preservative and assists in the inhibition of bacteria and deodorization.
  • the body shower gel does not contain preservatives and flavors, and the effect of the body is safe and lasting.
  • the shower gel of the present invention is a surface active shower gel, and the transparent shower gel and the pearlescent shower gel can be separately disposed according to the addition amount of the pearlescent agent.
  • the composite surfactant is an anionic surfactant sodium lauryl sulfate (ammonium) or sodium lauryl polyoxyethylene ether (ammonium) as a main surfactant, and a nonionic alkyl glycoside surfactant such as BASF. Plantacare2000up, Plantacare 818up and Glucopon 600cs up, or amphoteric surfactant cocamidopropyl betaine, a solution of sodium amphoteric acetate as a co-surfactant; ratio of primary surfactant to co-surfactant is 5:1 -2:1.
  • the composite surfactant is capable of rapid foaming, and the foam is smooth and easy to re-salt; the alkyl glycoside surface
  • the addition of the active agent not only removes dirt from the skin surface but also deepens the skin.
  • the skin conditioning agent seaweed polysaccharide of the invention has good moisturizing effect, and according to the Japanese Forest Research Institute, it is found that the seaweed polysaccharide has the effect of inhibiting the characteristic body odor of the middle-aged and the elderly; the polyquaternium-39 is a kind of three
  • the quaternary ammonium salt polymer conditioning agent is cationic in the product and has antibacterial and bactericidal action. It can be used as a skin conditioning agent to form a gas permeable membrane on the skin, which makes the skin smooth and comfortable.
  • the viscosity modifier of the present invention is a thickener commonly used in detergents.
  • the inorganic salt is one of sodium chloride, sodium sulfate and ammonium chloride; the hydroxyethyl cellulose is a cellulose derivative which can be used as a thickener or a skin lubricant.
  • the shower gel of the present invention can be adjusted to a pH of 5.5 to 6.5 with citric acid.
  • the significance of the present invention for the pH range of the shower gel is that the higher pH of the underarm secretion is considered to be an important factor leading to abnormal flora and secretion odor; the shower gel of pH 5.0-6.5 can be effectively reduced.
  • the pH of the apocrine gland secretions adjusts the microbial community structure.
  • an amphoteric surfactant such as betaine exhibits cationic properties and can exert both bactericidal and soft effects.
  • the biobacterial agent of the invention is the main functional ingredient of the body shower gel, the lactic acid bacteria fermentation extract and the oligofructose compound, the content of which is 1.0%-5.0%, preferably 2.0%, of the total weight of the body shower gel. 3.5%.
  • the biosuppressant may be a Yogurtene balance of Givaudan; or a lactic acid bacteria fermentation extract of Yogortene or Probiophyte Fresh of Givaudan and oligofructose (QHT-MSP) of Quantum Hi-Tech (China) Bio Co., Ltd.
  • the mixture of -1000S) has a compounding ratio of 1:5 to 10:1, preferably 1:4 to 1:1.
  • the lactic acid bacteria fermentation extract INCI name is LACTOCOCCUS FERMENT EXTRACT, and contains a fermentation product such as lactate or lactobacillus.
  • the lactic acid bacteria are a type of Gram-positive cocci or bacilli that utilizes carbohydrate fermentation to produce lactic acid in large quantities, including Lactobacillus and Lactococcus, and lactic acid. Any combination of Streptococcus lactis; preferably a combination of Lactobacillus plantarum, Lactobacillus crispatus, Lactobacillus acidophilus and Sepptococcus lactis of the genus Lactobacillus.
  • oligofructose INCI name is FRUCTOOLIGOSACCHARIDES, which is a hydrolysis product of inulin, and its structural formula is as follows:
  • oligofructose is 3-5 ⁇ -D-fructose fructose linked by ⁇ -2,1-bond
  • the percentage of trimeric fructose in the oligofructose of the present invention is 25%-45 %
  • the fructose has a weight percentage of 25% to 45%
  • the fructose has a weight percentage of 5% to 10%
  • the black pepper essential oil of the present invention is PIPER NIGRUM seed oil INCI name PIPER NIGRUM (PEPPER) SEED OIL in the "Used Cosmetic Raw Materials Catalogue", black pepper essential oil from colorless to pale amber, with pepper
  • the unique aroma, the flavor is mellow, natural and fresh, and it is the base material in the essential oil fragrance; its ingredients are eugenol, nutmeg oil ether, scutellaria and myrrh, tobacco, terpene, scorpion oleyl, limonene, Amemene, water fennel, pine oil, terpenes, snake olefins, cedarene and clove fume;
  • the grapefruit essential oil is obtained by pressing the skin
  • INCI name is CITRUS PARADISI (GRAPEFRUIT) PEEL OIL, fresh and sweet, with a fruity aroma of citrus, belonging to the top notes and body notes of the fragrance
  • the grapefruit essential oil mainly contains lim
  • citronellol and octanol, etc., and flavonoids have antibacterial activity.
  • the combination of black pepper essential oil and grapefruit essential oil conforms to the flavor regulation, and the fragrance is elegant and long, and the ability of the product to inhibit the pathogenic bacteria such as Brevibacterium epidermidis and Staphylococcus aureus is improved.
  • the preparation of the sustained-release essential oil is prepared by a liquid-liquid stirring method, and the black pepper essential oil and the grapefruit essential oil are compounded in a ratio of 2:1-1:2, and 100 ml of the ether-modified cyclodextrin is added according to 1 g of the compound essential oil. Stirring, crystallization, freeze-drying in a saturated solution; the ether-modified cyclodextrin is hydroxypropyl- ⁇ -cyclodextrin, hydroxyethyl- ⁇ -cyclodextrin or carboxymethyl- ⁇ -cyclodextrin One or any combination of which has a solubility greater than 40 g/L.
  • the prepared cyclodextrin inclusion essential oil not only has improved solubility in a water-based formulation, but also has an effect of prolonging the fragrance retention time.
  • the shower gel composition of the present invention can also assist in the addition of 3.0%-10.0% of long-term NEPHELIUM LONGANA SEED EXTRACT to enhance the efficacy of the body.
  • composition of the body shower gel of the present invention is the raw materials listed in the "Catalogue of Used Cosmetic Materials", and the cost is suitable for production conversion.
  • the fragrance shower gel of the present invention can be prepared by any known or otherwise effective technique suitable for providing body washes.
  • the method of preparing the biocide-containing shower gel of the present invention includes conventional formulation and agitation techniques.
  • the composition of which is: 7.0% sodium laureth sulfate, 2.1% cocamidopropyl betaine; 2.0% seaweed, 1.0% polyquaternium-39; % hydroxyethyl cellulose, 2.0% ethylene glycol distearate, 0.1% chelating agent disodium edetate and 1.0% biocide and 5.0% compounded slow release essential oil.
  • the composition of which is: 7.0% sodium laureth sulfate, 2.1% cocamidopropyl betaine; 2.0% seaweed, 1.0% polyquaternium-39; % hydroxyethyl cellulose, 2.0% ethylene glycol distearate, 0.1% chelating agent disodium edetate and 2.5% biocide and 2.5% compounded slow release essential oil.
  • the composition of which is: 7.0% sodium laureth sulfate, 3.0% sodium lauryl sulfate, 4.0% cocoyl alkyl glycoside; 2.0% trehalose, 1.0% polyquaternium Salt-39; 0.75% sodium chloride, 0.1% chelating agent disodium edetate and 1.0% biocide and 0.5% compounded slow release essential oil.
  • the composition of which is: 7.0% sodium laureth sulfate, 3.0% sodium lauryl sulfate, 4.0% cocoyl alkyl glycoside; 2.0% trehalose, 1.0% polyquaternium Salt-39; 0.75% sodium chloride, 0.1% chelating agent disodium edetate and 5.0% biocide and 5.0% compounded slow release essential oil.
  • the above-mentioned formula body shower gel has multiple functions such as clean, antibacterial, deodorizing and fragrance.
  • 0.3% triclosan substituted biosuppressant and compound slow-release essential oil were used as positive control, and the basic formula without bio-bacteriostatic agent and compound slow-release essential oil was used as a negative control; respectively, the treatment resulted in abnormal body odor.
  • the culture solution of Corynebacterium epidermidis was observed 3 days after plating, and the inhibition rate of the 1-4 against Corynebacterium epidermidis was similar to that of the positive control added with triclosan or the inhibition rate was higher than that of the positive control; 1-4
  • the number of Corynebacterium epidermidis was reduced from 1/5 to 1/10 of the negative control compared to the negative control without the addition of the biobacteria and the compounded slow release essential oil.
  • the comparison of Examples 1-4 and the addition of the same amount of commercially available flavors was carried out on the special fragrance paper provided by Engle (Shanghai) Flavors and Fragrances Co., Ltd., and the fragrance retention time of Example 1-4 was more than 3 days. And the commercial fragrance control is within 1 day.
  • Controls of Examples 1-4 and plus triclosan and equivalent commercial flavors were randomly distributed to 30 males aged 18-30 for 3 consecutive weeks, using standard shower gel for 3 weeks before the trial product, trial
  • the improvement of body odor evaluation, comfort evaluation, scent type and fragrance retention effect were respectively filled in the following days, 3 days, 7 days, 21 days, and 10 days after the suspension.
  • the results showed that the evaluations of comfort, fragrance and fragrance retention were superior to those of the control in Example 1-4.
  • the scores of improving body odor were close to those of the camera, and the scores of the improved body odors at 3 days, 7 days, and 21 days were also scored.
  • the superior control especially the one-day deactivation of 10 days, was significantly better than the control, indicating that the body lotion of the present invention has a longer safer and longer lasting body effect.

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Abstract

一种香体沐浴露，包含沐浴露基质、1.0重量％-5.0重量％的生物抑菌剂和0.5重量％-5.0重量％的复配缓释精油。所述生物抑菌剂为乳酸菌发酵提取物与低聚果糖复配物，其重量比为1:5-10:1，复配缓释精油为黑胡椒精油和葡萄柚果皮油与醚改性环糊精按照2:1:12-1:2:27比例制备。所述沐浴露不仅可以改善体味和实现持久留香的效果，还可以提高沐浴露的安全性。

Description

一种含有生物抑菌剂的香体沐浴露 技术领域
本发明涉及一种香体沐浴露，特别是一种含有生物抑菌剂的香体沐浴露。
背景技术
腋臭又名狐臭、臭汗症等，是由患者腋窝、外阴、口角等部位的大汗腺(又叫顶浆腺)排泄的汗液，脂肪酸比普通人高，呈淡黄色，较浓稠。汗液本身是无味的，但皮肤是天然细菌的生存场所，某些细菌以顶浆腺分泌的高浓度脂肪酸汗液为食，产生六碳至十碳的不饱和支链脂肪酸，主要是3—反—2—甲基已酸及50—雄烯酮而发出和狐狸肛门排除的气味相似的臭味，所以常称为狐臭。体味较重会引起社这种交障碍甚至心理疾病。因此，很多人每天都会使用香体剂来控制体臭。市面的香体剂产品包括乳液、喷雾、滚珠和胶棒等不同形式，但其基本配方组成是相近的主要功效成分为抗菌剂，辅助添加芳香剂、皮肤调理剂、不同属性产品的赋形剂以及使其能够有效地施用于皮肤上的载体成分。抗菌剂能够杀灭细菌，减缓其生长速度。止汗剂中的铝盐是天然的抗菌剂，因此它们也会杀灭皮肤上的细菌，但干扰人体代谢，不宜经常使用；目前报道多种不含铝盐的高效香体剂，这些香体剂依靠的是特别研发的抗菌剂，如三氯生或聚六亚甲基双胍。这种化学合成的抗菌剂具有广谱的抑菌作用，同时也会导致细菌耐药性和皮肤残留刺激，引起皮肤过敏；目前研究表明三氯生和三氯卡班可能会干扰人体荷尔蒙，在美国已拟定议案禁止含此类抗菌剂的抗菌皂和沐浴 露的实体销售。对于消费者来说，安全当然是首先考虑的。因此，开发更安全、高效的香体抑菌剂成为一种潜在消费需求。
人与细菌是伴随生存的，有对抗也有互利。已知的皮肤上的很多有益细菌可以训练人的免疫系统，所以关键不是没有细菌，而是保持健康的菌群平衡。基于菌群平衡原理，雀巢产品股份有限公司申请专利保护乳杆菌科Lactobacillus CNCM I-1225或CNCM I-2116或其培养上清及其食品、药品、化妆品制剂作为微生态制剂调节皮肤免疫系统，治疗物理、化学或生物的压力导致的炎症和照射效应(CN01816819.1)；巴斯夫欧洲公司申请保护微生物及其灭活物的抑制腋臭用途，他们是属于乳酸细菌类的微生物，尤其指乳杆菌科Lactobacillus(CN200680033490)。低聚果糖是一种天然活性物质，国家卫生部公告(2008年第16号)批准了低聚果糖作为化妆品原料使用，用于抑制皮肤有害菌的生长，具有皮肤保健作用。CN1562049A描述了低聚果糖在制备治疗和预防阴道炎药物中的应用，促进乳酸杆菌、双歧杆菌等益生菌生长改善女性阴道微环境，抑制病原菌。
中草药香体剂在中医中药古方中早有记载：《本草纲目》治狐臭方：将小龙眼核6个与胡椒14粒研成细末，遇腋汗出时即用药擦腋下；《必用全书》有汗臭者适用贵人挹汗香方：用丁香40克，川椒60粒。先将丁香研成细末，川椒打碎，然后把两味药物混合拌匀，用绢袋盛装，佩戴于胸前，能绝汗臭、香身。但这些中医药古方尚未融入现代生活元素，其施用方式并不适合现代便捷的生活方式。
基于以上香体产品研发的现状和弊端，本发明以沐浴露基质添加乳酸菌-低聚果糖生物抑菌剂和中草药抑菌芳香精油，开发复合型抑菌香体沐浴露。
发明内容
本发明的目的是提供一种生物抑菌剂的香体沐浴露，不仅可以改善体味和实现持久留香效果，还可以提高香体沐浴露的安全性。
一种含有生物抑菌剂的香体沐浴露，所述沐浴露基质包括：
占组合物重量7.0％-35.0％的复合表面活性剂；
占组合物重量1.0％-5.0％的皮肤调理剂；
占组合物重量0.1％-2.0％的黏度调节剂；
占组合物重量0.0％至3.5％的珠光剂；
占组合物重量0.05％-0.2％的螯合剂；
其特征在于还包含占沐浴露总重量1.0％-5.0％的生物抑菌剂和总重量0.5％-5.0％的复配缓释精油；
其中所述的生物抑菌剂为乳酸菌发酵提取物与低聚果糖复配物，其重量比为1:5-10:1；
复配缓释精油为黑胡椒精油和葡萄柚果皮油与醚改性环糊精按照重量比2:1:12-1:2:27比例制备；
沐浴露各组分含量不足百分之百时用去离子水补足。
本发明所述复合表面活性剂是月桂醇硫酸盐、月桂醇聚氧乙烯醚硫酸盐中的一种和C8-C14烷基糖苷、椰油酰胺丙基甜菜碱、两性醋酸钠中一种的组合物；所述皮肤调理剂为1.0％-5.0％的海藻聚糖和0-1.0％聚季铵盐-39；所述粘度调节剂是羟乙基纤维素和无机盐中的一种；所述珠光剂是乙二醇双硬脂酸酯和乙二醇单硬脂酸酯中的一种；所述螯合剂是乙二胺四乙酸二钠。
本发明所述的香体沐浴露pH小于7.0，优选pH为5.0-6.5。
本发明所述低聚果糖为重量百分比25％-45％三聚果糖、重量百分比25％-45％四聚果糖、重量百分比5％-10％五聚果糖和重量百分比0-5％蔗糖的混合物。
本发明所述乳酸菌为乳酸杆菌(Lactobacillus)和乳酸球菌(Lactococcus)以及乳酸链球菌(Sreptococcus lactis)的任意组合。
本发明所述醚改性环糊精为羟乙基-β-环糊精和羟丙基β-环糊精的任意组合。
本发明的有益效果是：所述生物抑菌剂的加入，不仅没有化学抑菌剂的刺激性还可以给皮肤带来滋润感，更重要的是抑制导致汗液异味的病原菌生长而促进产生抗菌素的有益菌生长，长期使用可以调节皮肤微生态，改善体味异常。
所述皮肤调理剂海藻聚糖既有良好的保湿效果，据日本林原生物研究所发现海藻糖具有吸附抑制中老年人特有体臭的作用。
所述黑胡椒精油和葡萄柚精油复配的缓释制剂不仅具有芳香持久的特性而且可以组成天然的防腐剂，并辅助抑菌除臭。
所述香体沐浴露不添加防腐剂、香精，香体效果安全持久。
本发明内容详细说明如下：
本发明所述沐浴露为表活型沐浴露，以珠光剂的添加量不同，可分别配置透明型沐浴露和珠光型沐浴露。所述复合表面活性剂以阴离子表面活性剂月桂醇硫酸钠(铵)或月桂醇聚氧乙烯醚硫酸钠(铵)作为主表面活性剂，以非离子烷基糖苷型表面活性剂，如巴斯夫公司的Plantacare2000up 、Plantacare 818up和Glucopon 600cs up，或两性表面活性剂椰油酰胺丙基甜菜碱、两性醋酸钠的一种为助表面活性剂；主表面活性剂与助表面活性剂的比例为5:1-2:1。所述复合表面活性剂能够快速起泡，泡沫细腻柔滑易于重新；烷基糖苷类表面 活性剂添加不仅清除皮肤表面污垢而且可以深层清洁皮肤。
本发明所述皮肤调理剂海藻聚糖既有良好的保湿润肤效果，据日本林原生物研究所发现海藻聚糖具有吸附抑制中老年人特有体臭的作用；聚季铵盐-39是一种三元共聚的季铵盐高分子调理剂，在产品中呈阳离子性，具有抑菌杀菌作用，用作皮肤调理剂可以在皮肤上形成透气膜，使得皮肤光滑和舒爽。
本发明所述黏度调节剂为洗涤用品常用增稠剂。其中无机盐为氯化钠、硫酸钠、氯化铵中的一种；羟乙基纤维素为纤维素衍生物既可以作为增稠剂也可以作为皮肤润滑剂。
本发明沐浴露可用柠檬酸调节pH为5.5-6.5。本发明对所述沐浴露pH范围要求的意义在于：腋下分泌物pH较高被认为是导致其菌群异常，分泌物异味的一个重要因素；pH5.0-6.5的沐浴露能够有效的降低大汗腺分泌物的pH，调整微生物群落结构。而且在此pH值下，甜菜碱等两性表面活性剂显示阳离子特性，可以发挥杀菌和柔软双重功效。
本发明所述生物抑菌剂为香体沐浴露的主要功效成分，乳酸菌发酵提取物与低聚果糖复配物，其含量占香体沐浴露总重量的1.0％-5.0％，优选2.0％-3.5％。所述生物抑菌剂可以为奇华顿公司的Yogurtene balance；也可以为乳酸菌发酵提取物奇华顿公司的Yogortene或Probiophyte Fresh与量子高科(中国)生物股份有限公司的低聚果糖(QHT-MSP-1000S)的混合物其复配比例为1:5-10:1，优选1:4-1:1。
所述乳酸菌发酵提取物INCI名称为LACTOCOCCUS FERMENT EXTRACT，包含乳酸盐、乳酸菌素等发酵产物。
所述乳酸菌为一类利用碳水化合物发酵大量产生乳酸的革兰氏阳性球菌或杆菌，包括乳酸杆菌(Lactobacillus)和乳酸球菌(Lactococcus)以及乳酸 链球菌(Sreptococcus lactis)的任意组合；优选乳酸杆菌属的胚芽乳杆菌(Lactobacillus plantarum)、卷曲乳杆菌(Lactobacillus crispatus)、嗜酸乳杆菌(Lactobacillus acidophilus)与乳酸链球菌(Sreptococcus lactis)的组合。
所述低聚果糖INCI名称为FRUCTOOLIGOSACCHARIDES，为菊粉的水解产物，其结构式如下：
Figure PCTCN2014093561-appb-000001
式中n＝1-3，低聚果糖为3-5个β-D-呋喃果糖通过β-2，1-键连接，本发明所述低聚果糖中三聚果糖重量百分比为25％-45％，四聚果糖重量百分比为25％-45％、五聚果糖重量百分比为5％-10％，还含有重量百分比为0-5％蔗糖的混合物。
本发明所述黑胡椒精油，在《已使用化妆品原料目录》中为胡椒(PIPER NIGRUM)籽油INCI名称为PIPER NIGRUM(PEPPER)SEED OIL，黑胡椒精油从无色到淡琥珀色，具有胡椒所特有的香气，风味醇香浑厚，自然清新，属于精油调香中的基香原料；其成分为丁香酚、肉豆蔻油醚、黄樟脑以及没药萜烟、樟烯、麝子油烯、柠檬烯、杨梅烯、水茴香萜、松油萜、桧烯、蛇床烯、侧柏烯和丁香油烟；所述葡萄柚精油是由果皮压榨而得的，INCI名称为CITRUS  PARADISI(GRAPEFRUIT)PEEL OIL，气味清新、香甜，有柑橘的果香味，属于调香的头香和体香的香型；所述葡萄柚精油主要含柠檬烯(约占90％)，其余为柠檬醛、香茅醇和辛醇等，又含黄酮类化合物具有抑菌活性。黑胡椒精油和葡萄柚精油的复配符合调香规律，香型淡雅悠长，而且提高了产品抑制表皮短杆菌以及金黄色葡萄球菌等条件致病菌的能力。
所述缓释精油制备是以液-液搅拌法制备，将黑胡椒精油和葡萄柚精油以2:1-1:2比例复配，按照1g复配精油加入到的100ml醚改性环糊精饱和溶液中，搅拌、结晶、冷冻干燥；所述醚改性环糊精为羟丙基-β-环糊精、羟乙基-β-环糊精或羧甲基-β-环糊精中的一种或者任意组合，其溶解度大于40g/L。所制备的环糊精包合精油不仅在水基配方中溶解性提高，而且具有延长留香时间的效果。
本发明沐浴露组合物的基础上还可以辅助添加3.0％-10.0％的龙眼(NEPHELIUM LONGANA)籽提取物(NEPHELIUM LONGANA SEED EXTRACT)以增强香体的功效。
本发明所述香体沐浴露组分均为《已使用化妆品原料目录》中列出的原料，成本适宜，便于生产转化。
具体实施方式
本发明的香体沐浴露可以通过任何已知或其它有效的适用于提供沐浴露的技术制备，制备本发明的含有生物抑菌剂的沐浴露的方法包括常规的配制和搅拌技术。
下面是本发明的香体沐浴露的非限定性实例。这些实施例的给出仅仅是为了说明的目的，并不能理解为对本发明的限定，因为在不脱离本发明的精神和 范围的基础上，可以对本发明进行许多改变。在这些实施例中，除非特别说明，所有的浓度都是重量百分比。
实施例1
制备本发明香体沐浴露，其组分为：7.0％月桂醇聚氧乙烯醚硫酸钠，2.1％椰油酰胺丙基甜菜碱；2.0％海藻聚糖，1.0％聚季铵盐-39；0.3％羟乙基纤维素，2.0％乙二醇双硬脂酸酯，0.1％螯合剂乙二胺四乙酸二钠以及1.0％的生物抑菌剂和5.0％的复配缓释精油。
实施例2
制备本发明香体沐浴露，其组分为：7.0％月桂醇聚氧乙烯醚硫酸钠，2.1％椰油酰胺丙基甜菜碱；2.0％海藻聚糖，1.0％聚季铵盐-39；0.3％羟乙基纤维素，2.0％乙二醇双硬脂酸酯，0.1％螯合剂乙二胺四乙酸二钠以及2.5％的生物抑菌剂和2.5％的复配缓释精油。
实施例3
制备本发明香体沐浴露，其组分为：7.0％月桂醇聚氧乙烯醚硫酸钠，3.0％月桂醇硫酸钠，4.0％椰油基烷基糖苷；2.0％海藻糖，1.0％聚季铵盐-39；0.75％氯化钠，0.1％螯合剂乙二胺四乙酸二钠以及1.0％的生物抑菌剂和0.5％的复配缓释精油。
实施例4
制备本发明香体沐浴露，其组分为：7.0％月桂醇聚氧乙烯醚硫酸钠，3.0％月桂醇硫酸钠，4.0％椰油基烷基糖苷；2.0％海藻糖，1.0％聚季铵盐-39；0.75％氯化钠，0.1％螯合剂乙二胺四乙酸二钠以及5.0％的生物抑菌剂和5.0％的复配缓释精油。
以上配方组成的香体沐浴露具有清洁、抑菌除臭、留香等多重功效。以上实施例以0.3％三氯生取代生物抑菌剂和复配缓释精油作为阳性对照，与不添加生物抑菌剂和复配缓释精油的基础配方为阴性对照；分别处理导致体味异常的表皮棒杆菌的培养液，涂板后3天后观察，实施例1-4对表皮棒杆菌的抑菌率与添加三氯生的阳性对照抑菌率相近或者抑菌率高于阳性对照；实施例1-4与不添加生物抑菌剂和复配缓释精油的阴性对照相比，表皮棒杆菌的数量减少为阴性对照的1/5至1/10。实施例1-4和添加等量的市售香精的对照涂在恩格乐(上海)香精香料公司提供的专用闻香纸上留香时间对比，实施例1-4留香时间在3天以上，而市售香精对照都是在1天以内。
将实施例1-4和加三氯生和等量市售香精的对照对照随机发给30个年龄18-30的男性青年连续试用3周，其在试用产品前使用标准沐浴露3周，试用后1天、3天、7天、21天和停用后10天分别填写改善体味评价、舒适度评价、香型和留香效果评价。结果表明实施例1-4在舒适度、香型和留香效果评价都较对照优胜，在1天后改善体味的评分与对照相近，在3天、7天、21天的改善体味项的评分也优胜对照，特别是停用10天的评价显著优于对照，表明本发明的香体沐浴露长期具有更安全持久的香体效果。

Claims (6)

  1. 一种含有生物抑菌剂的香体沐浴露，所述沐浴露基质包含：
    占组合物重量7.0％-35.0％的复合表面活性剂；
    占组合物重量1.0％-5.0％的皮肤调理剂；
    占组合物重量0.1％-2.0％的黏度调节剂；
    占组合物重量0.0％至3.5％的珠光剂；
    占组合物重量0.05％-0.2％的螯合剂；
    其特征在于还包含占沐浴露总重量1.0％-5.0％的生物抑菌剂和总重量0.5％-5.0％的复配缓释精油；
    其中所述的生物抑菌剂为乳酸菌发酵提取物与低聚果糖复配物，其重量比为1:5-10:1；
    复配缓释精油为黑胡椒精油和葡萄柚果皮油与醚改性环糊精按照2:1:12-1:2:27比例制备。
  2. 根据权利要求1所述的香体沐浴露，其特征在于，根据其中所述复合表面活性剂是月桂醇硫酸盐、月桂醇聚氧乙烯醚硫酸盐中的一种和C8-C14烷基糖苷、椰油酰胺丙基甜菜碱、两性醋酸钠中一种的组合物；所述皮肤调理剂为重量百分比1.0％-5.0％海藻聚糖和重量百分比0-1.0％的聚季铵盐-39；所述黏度调节剂是羟乙基纤维素和无机盐中的一种；所述珠光剂是乙二醇双硬脂酸酯和乙二醇单硬脂酸酯中的一种；所述螯合剂是乙二胺四乙酸二钠。
  3. 根据权利要求2所述的香体沐浴露，其特征在于所述低聚果糖为重量百分比25％-45％三聚果糖、重量百分比25％-45％四聚果糖、重量百分比5％-10％五聚果糖和重量百分比0-5％蔗糖的混合物。
  4. 根据权利要求3所述的香体沐浴露，其特征在于所述乳酸菌为乳酸杆菌(Lactobacillus)和乳酸球菌(Lactococcus)以及乳酸链球菌(Sreptococcus lactis)的任意组合。
  5. 根据权利要求4所述的香体沐浴露，其特征在于所述醚改性环糊精为羟乙基-β-环糊精和羟丙基β-环糊精的任意组合。
  6. 根据权利要求5所述的香体沐浴露，其特征在于其pH为5.0-6.5。
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