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WO2016084100A3 - Novel and efficient method for large scale synthesis of romidepsin - Google Patents

Novel and efficient method for large scale synthesis of romidepsin Download PDF

Info

Publication number
WO2016084100A3
WO2016084100A3 PCT/IN2015/000435 IN2015000435W WO2016084100A3 WO 2016084100 A3 WO2016084100 A3 WO 2016084100A3 IN 2015000435 W IN2015000435 W IN 2015000435W WO 2016084100 A3 WO2016084100 A3 WO 2016084100A3
Authority
WO
WIPO (PCT)
Prior art keywords
romidepsin
novel
large scale
efficient method
scale synthesis
Prior art date
Application number
PCT/IN2015/000435
Other languages
French (fr)
Other versions
WO2016084100A2 (en
Inventor
Lakshmi Prasad ALAPARTHI
Ganga Ramu VASANTHAKUMAR
Talluri Bhushaiah CHOWDARY
Anand Vijaykumar MANTRI
Gaurav Kulkarni
Original Assignee
Alaparthi Lakshmi Prasad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alaparthi Lakshmi Prasad filed Critical Alaparthi Lakshmi Prasad
Publication of WO2016084100A2 publication Critical patent/WO2016084100A2/en
Publication of WO2016084100A3 publication Critical patent/WO2016084100A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to intermediate compounds which are used as key intermediates in the synthesis of Romidepsin and process of preparation of these intermediates. The present invention also provides processes for synthesis of Romidepsin in high purity and good yields from said intermediate compounds.
PCT/IN2015/000435 2014-11-26 2015-11-26 Novel and efficient method for large scale synthesis of romidepsin WO2016084100A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3757/MUM/2014 2014-11-26
IN3757MU2014 2014-11-26

Publications (2)

Publication Number Publication Date
WO2016084100A2 WO2016084100A2 (en) 2016-06-02
WO2016084100A3 true WO2016084100A3 (en) 2016-07-21

Family

ID=56075101

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000435 WO2016084100A2 (en) 2014-11-26 2015-11-26 Novel and efficient method for large scale synthesis of romidepsin

Country Status (1)

Country Link
WO (1) WO2016084100A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2623979T3 (en) 2013-03-21 2017-07-12 Sanofi-Aventis Deutschland Gmbh Synthesis of peptide products containing hydantoin
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
CN111333697B (en) * 2018-12-19 2022-03-08 深圳翰宇药业股份有限公司 Synthesis method of romidepsin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102241736A (en) * 2011-05-13 2011-11-16 江苏江神药物化学有限公司 Method for synthesizing key intermediate of antitumour medicament Romidepsi
WO2014101828A1 (en) * 2012-12-27 2014-07-03 深圳翰宇药业股份有限公司 Method for preparing romidepsin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102241736A (en) * 2011-05-13 2011-11-16 江苏江神药物化学有限公司 Method for synthesizing key intermediate of antitumour medicament Romidepsi
WO2014101828A1 (en) * 2012-12-27 2014-07-03 深圳翰宇药业股份有限公司 Method for preparing romidepsin

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SALVATORE DI ET AL.: "Efficient Solid-Phase Synthesis of FK228 Analogues as Potent Antitumoral Agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 6639 - 6541 *
SHIJUN WEN ET AL.: "Macrolactamization versus Macrolactonization: Total Synthesis of FK228, the Depsipeptide Histone Deacetylase Inhibitor", JOURNAL OF ORGANIC CHEMISTRY, vol. 73, 2008, pages 9353 - 9361 *

Also Published As

Publication number Publication date
WO2016084100A2 (en) 2016-06-02

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