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WO2015198263A3 - Novel betulinic proline substituted derivatives as hiv inhibitors - Google Patents

Novel betulinic proline substituted derivatives as hiv inhibitors Download PDF

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Publication number
WO2015198263A3
WO2015198263A3 PCT/IB2015/054784 IB2015054784W WO2015198263A3 WO 2015198263 A3 WO2015198263 A3 WO 2015198263A3 IB 2015054784 W IB2015054784 W IB 2015054784W WO 2015198263 A3 WO2015198263 A3 WO 2015198263A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted derivatives
proline substituted
hiv inhibitors
novel betulinic
betulinic
Prior art date
Application number
PCT/IB2015/054784
Other languages
French (fr)
Other versions
WO2015198263A2 (en
Inventor
Parthasaradhi Reddy BANDI
Rathnakar Reddy KURA
Panduranga Reddy ADULLA
David Krupadanam GAZULA LEVI
Eswara Rao BAMMIDI
Ranga Reddy KOTHAKAPU
Vl Subrahmanyam LANKA
Original Assignee
Hetero Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hetero Research Foundation filed Critical Hetero Research Foundation
Priority to US15/321,970 priority Critical patent/US20170129916A1/en
Publication of WO2015198263A2 publication Critical patent/WO2015198263A2/en
Publication of WO2015198263A3 publication Critical patent/WO2015198263A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention relates to novel betulinic proline substituted derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases. Formula (I)
PCT/IB2015/054784 2014-06-26 2015-06-25 Novel betulinic proline substituted derivatives as hiv inhibitors WO2015198263A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US15/321,970 US20170129916A1 (en) 2014-06-26 2015-06-25 Novel betulinic proline imidazole derivatives as hiv inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3117/CHE/2014 2014-06-26
IN3117CH2014 2014-06-26

Publications (2)

Publication Number Publication Date
WO2015198263A2 WO2015198263A2 (en) 2015-12-30
WO2015198263A3 true WO2015198263A3 (en) 2016-03-10

Family

ID=54938891

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/054784 WO2015198263A2 (en) 2014-06-26 2015-06-25 Novel betulinic proline substituted derivatives as hiv inhibitors

Country Status (1)

Country Link
WO (1) WO2015198263A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
MA40886B1 (en) 2015-02-09 2020-03-31 Hetero Research Foundation Novel c-3 triterpenone with c-28 reverse amide derivatives as hiv inhibitors
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
JPWO2022270628A1 (en) * 2021-06-25 2022-12-29

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006053255A2 (en) * 2004-11-12 2006-05-18 Panacos Pharmaceuticals, Inc. Novel betulin derivatives, preparation thereof and use thereof
WO2010132334A1 (en) * 2009-05-15 2010-11-18 The University Of North Carolina At Chapel Hill 3,28-disubstituted betulinic acid derivatives as anti-hiv agents
WO2011007230A2 (en) * 2009-07-14 2011-01-20 Hetero Research Foundation Lupeol-type triterpene derivatives as antivirals
WO2011153319A1 (en) * 2010-06-04 2011-12-08 Bristol-Myers Squibb Company C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006053255A2 (en) * 2004-11-12 2006-05-18 Panacos Pharmaceuticals, Inc. Novel betulin derivatives, preparation thereof and use thereof
WO2010132334A1 (en) * 2009-05-15 2010-11-18 The University Of North Carolina At Chapel Hill 3,28-disubstituted betulinic acid derivatives as anti-hiv agents
WO2011007230A2 (en) * 2009-07-14 2011-01-20 Hetero Research Foundation Lupeol-type triterpene derivatives as antivirals
WO2011153319A1 (en) * 2010-06-04 2011-12-08 Bristol-Myers Squibb Company C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"ANIH Public Access Published in final edited form as", J MED CHEM., vol. 52, no. 23, 10 December 2009 (2009-12-10), pages 7887 - 7891 *
F. LI ET AL.: "PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing", PROC.NATL.ACAD.SCI.U.SA., vol. 100, no. 23, 2003, pages 13555 - 13560, XP002396265, DOI: doi:10.1073/pnas.2234683100 *
YOSHIKIKASHIWADA ET AL.: "Betulinic Acid and Dihydrobetulinic Acid Derivatives as Potent Anti-HIV Agents", J. MED. CHEM., vol. 39, no. 5, 1996, pages 1016 - 1017 *

Also Published As

Publication number Publication date
WO2015198263A2 (en) 2015-12-30

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