WO2013136802A1

WO2013136802A1 - Drug administration device

Info

Publication number: WO2013136802A1
Application number: PCT/JP2013/001720
Authority: WO
Inventors: 孝博相馬
Original assignee: テルモ株式会社
Priority date: 2012-03-16
Filing date: 2013-03-14
Publication date: 2013-09-19

Abstract

Achieved is a drug administration device that enables the delivery of a fixed quantity of a drug while being compact. When a rotating screw section (137) is turned in the clockwise direction or counterclockwise direction, a delivery section (130) causes a piston (132) to make a half-turn in the clockwise direction or counterclockwise direction by means of screw friction, causing an outer peripheral surface opening (132BH) to connect to an inflow tube (131C) or an outflow tube (131D), causes a claw section (135A) to contact a regulation plate (136B or 136C), regulating rotation, causes the piston (132) to move to the left or to the right by means of the threading between screw section (137A) and screw section (135B), causes the drug to flow in from the inflow tube (131C) into a storage space (131L), and causes the drug to flow out from within the storage space (131L) to the outflow tube (131D). Also, the delivery section (130) can function as a pump that alternately causes the inflow and outflow of the drug by means of cyclically switching the direction of rotation of the rotating screw section (137).

Description

Chemical solution administration device

The present invention relates to a drug solution administration device, which is suitable for application when, for example, insulin is administered into the body.

In recent years, diabetes has shown an increasing trend in the number of patients worldwide, including Japan. In addition, there is a concern about the associated increase in treatment costs. Among diabetes, type 1 diabetes is a chronic disease that requires treatment to inject an appropriate amount of insulin at an appropriate time. For a long time, manual administration using a syringe or manual administration using an injector has been performed. In order to carry out appropriate treatment more simply, safely, and automatically, an automatic drug solution administration system capable of programming the dose and administration time has been developed.

This system consists of an infusion pump, a dedicated infusion set, and a catheter. At present, a system in which a drug administration device is made portable is also used. Recently, in this portable system, in order to eliminate the troublesomeness of the tube of the infusion set and to improve handling, a small and lightweight infusion pump that is fixed to the body surface with a double-sided tape without using the infusion set. A patch-type drug solution administration device has been introduced in which a catheter is directly inserted from the device (for example, see Patent Document 1).

Special table 2010-501283

By the way, in the conventional liquid medicine administration device, the liquid medicine is delivered from the liquid medicine storage section filled with the liquid medicine into the patient's body using a pump.

Since a chemical solution administration device needs to administer a fixed amount of chemical solution into the body of a patient, a pump capable of quantitative suction and discharge of the chemical solution must be used.

As such a pump, a cylinder part is provided with a suction port for suctioning a chemical solution and a discharge port for discharging a chemical solution, and a check valve is provided at each of the suction port and the discharge port. A piston type pump is known in which one of check valves provided at each of the suction port and the discharge port is opened by changing the internal pressure of the pump.

However, such a conventional pump uses a passive valve as a check valve, and leakage, a large valve opening pressure, and variations in the valve opening pressure have had a great influence on the pump performance. . Further, when an active type valve is used as a countermeasure, the configuration becomes complicated and it is difficult to reduce the size.

The present invention has been made in consideration of the above points, and intends to propose a small-sized chemical solution administration device capable of quantitatively delivering a chemical solution.

In order to solve such a problem, in the drug administration device of the present invention, the drug administration device is used by being attached to the body surface of the user, the drug solution storage unit storing the drug solution, and the cylindrical inner peripheral side surface And a cylinder having a bottom surface of a predetermined shape, a reservoir for supplying a chemical solution, an inflow port formed on an inner peripheral side surface of the cylinder communicating with an inflow passage connected to the reservoir, and the chemical solution into the body of the user An outflow port provided on an inner peripheral side surface of the cylinder that communicates with a hollow needle to be supplied through a predetermined outflow path, and formed at a position rotated from the inflow port by a predetermined angle about the central axis of the cylinder; An outer peripheral side surface in contact with the inner peripheral side surface, an end surface in contact with the chemical solution, the other end surface facing the end surface, and an outer peripheral side surface port provided on the outer peripheral side surface and a flow passage connecting the end surface are provided. Perimeter and bottom A piston that slides in the cylinder inner space formed in the direction of the center axis of the cylinder, a piston screw portion that has a thread groove formed on the other end surface side of the piston, and a piston screw portion that are screwed together. A rotating screw portion that is rotated about the central axis of the cylinder and that generates a screw friction force between the piston screw portion that is larger than a peripheral side friction force generated between the cylinder and the piston when rotating. In the cylinder, when the piston rotates around the central axis of the cylinder, the piston azimuth that the outer peripheral side port faces is the inflow azimuth that connects the outer peripheral side port to the inlet, and the piston is rotated from the inflow azimuth. A rotation restricting portion for restricting the rotation within a rotation range sandwiched between the outflow direction for connecting the outer peripheral side surface port to the outflow port is provided.

As a result, when the rotating screw portion is rotated in a predetermined direction, first, the piston is rotated in this predetermined direction by the action of the screw friction force, and the outer peripheral side surface port is connected to the inflow port according to the inflow direction, and the rotation is performed in this state The restriction part restricts the rotation of the piston. Subsequently, the piston pump moves the piston in a direction away from the bottom surface of the cylinder by screwing the rotating screw portion and the piston screw portion to generate negative pressure in the cylinder, and from the reservoir through the inflow pipe and the flow pipe. The chemical solution can flow into the cylinder. When the rotating screw part is rotated in the opposite direction, first, the piston is rotated in the opposite direction by the action of the screw friction force, and the outer peripheral side port is connected to the outlet in accordance with the outflow direction. The rotation of the piston is restricted. Subsequently, the piston pump moves the piston in a direction close to the bottom surface of the cylinder by screwing the rotating screw portion and the piston screw portion to generate a positive pressure in the cylinder, and from the inside of the cylinder through the flow pipe and the outflow pipe. The drug solution can be drained into the body of the user.

According to the present invention, only by rotating the rotating screw part in a predetermined direction or in the opposite direction, the piston is first rotated by the action of the screw friction force, and the connection destination of the outer peripheral side surface port is set to either the inflow port or the outflow port. After switching, the piston can be separated or close to the bottom surface of the cylinder by screwing between the rotating screw portion and the piston screw portion, so that the chemical liquid can flow into or out of the cylinder. Thus, it is possible to realize a small-sized chemical solution administration device capable of quantitatively delivering the chemical solution.

It is a basic diagram which shows the structure of a chemical | medical solution administration system. It is a basic diagram which shows the structure of a chemical | medical solution administration apparatus. It is a disassembled perspective view of a chemical | medical solution storage delivery part. It is a basic diagram which shows before and after storage of a chemical | medical solution. It is a basic diagram which shows the formation process of a chemical | medical solution bag. It is a basic diagram which shows the structure of a filter part. It is a basic diagram which shows the structure of a sending part. It is a basic diagram which shows the structure of a sending part. It is a basic diagram with which it uses for description of the inflow operation of a sending part. It is a basic diagram with which it uses for description of the outflow operation | movement of a sending part. It is a disassembled perspective view of a drive control part. It is a basic diagram which shows the mechanism of power transmission. It is a basic diagram which shows the structure of a connector. It is a basic diagram which shows the structure of a puncture flow path part. It is a basic diagram which shows the structure of a puncture flow path part. It is a basic diagram which shows the structure of a crimping and a press part. It is a basic diagram which shows the mode of puncture. It is a basic diagram which shows the structure of an angle adjustment mechanism. It is a basic diagram which shows mounting of the knob part in an angle adjustment mechanism. It is a basic diagram which shows the change of the protrusion angle in an angle adjustment mechanism. It is a basic diagram which shows the circuit structure and functional structure of a chemical | medical solution administration system. It is a basic diagram which shows the structure of the sending part in other embodiment. It is a basic diagram which shows the structure of the sending part in other embodiment. It is a basic diagram which shows the structure of the screw receiving part in other embodiment. It is a basic diagram which shows the structure of the sending part in other embodiment. It is a basic diagram which shows the structure of the sending part in other embodiment. It is a basic diagram which shows the structure of the sending part in other embodiment. It is a basic diagram which shows the structure of the sending part in other embodiment. It is a basic diagram which shows the structure of the sending part in other embodiment. It is a basic diagram which shows the structure of the sending part in other embodiment. It is a basic diagram which shows the structure of the sending part in other embodiment.

Hereinafter, an embodiment of the present invention will be described in detail with reference to the drawings.

[1. Configuration of chemical solution administration system]
As shown in FIG. 1, a drug solution administration system 1 wirelessly communicates a signal corresponding to a user's input instruction with a portable drug solution administration device 2 that is held and used by being affixed to the user's skin. The controller 3 that transmits to the drug solution administration device 2 and the charger 4 (FIG. 21) that charges the rechargeable battery 206 (FIG. 11) provided inside the drug solution administration device 2 are configured.

[2. Configuration of chemical administration device]
The medicinal solution administration device 2 stores a medicinal solution (for example, insulin) therein, is set by the controller 3, is transmitted by radio, and is stored in the memory in the medicinal solution administration device 2, and the bolus administration time and dose. The drug solution is administered into the user's body according to the administration time and the dose, or according to the bolus dose transmitted from the controller 3. As shown in FIG. 2, the drug solution administration device 2 includes a drug solution storage and delivery unit 10, a drive control unit 20, and a puncture channel unit 30 that are detachable from each other.

In the drug solution administration device 2, after the drug solution storage / delivery unit 10 and the drive control unit 20 are engaged from above and below, the puncture channel unit 30 is slid from the front with respect to the drug solution storage / delivery unit 10 and the drive control unit 20. To be integrated. The medicinal solution administration device 2 is used by being attached to the skin of the user in such a state.

The size of the medicinal solution administration device 2 may be small enough to be attached to the user's skin, for example, a substantially rectangular parallelepiped shape having a width of 34 mm, a length of 43 mm, and a height of 12 mm.

[2-1. (Configuration of chemical storage and delivery unit)
As shown in FIG. 3 and FIG. 4, the chemical storage / delivery unit 10 includes a lower casing part 101 that is open on the upper side and has a space inside, and an upper casing that is screwed into the opening of the lower casing part 101. The portion 102 is formed into a flat and substantially rectangular parallelepiped shape.

The chemical solution storage and delivery unit 10 is provided with a chemical solution bag 110, a filter unit 120, a delivery unit 130, a compression unit 150, and the like in a space formed by the lower casing unit 101 and the upper casing unit 102.

The lower housing part 101 is provided with a sticking part 103 made of double-sided tape or the like on the bottom face 101A. The medicinal solution administration device 2 is held by the user when the sticking portion 103 is stuck on the user's skin. The bottom surface 101 A of the lower housing 101 is formed of a transparent material so that the amount of the chemical stored in the chemical bag 110 can be seen from the outside. This makes it possible to check the remaining amount of the drug solution from the lateral direction even after the drug solution administration device 2 is attached to the user's skin.

Engagement portions 101B to E, which are protrusions extending in the direction in which the drive control unit 20 is arranged, are provided on the side surfaces along the longitudinal direction (hereinafter also referred to as the front-rear direction) of the lower housing unit 101. It has been. The engaging portions 101B to E are brought into close contact with the chemical solution storage and delivery portion 10 and the drive control portion 20 by engaging with engagement receiving portions 201A to 201D (FIG. 11) described later.

The lower casing 101 is provided with a waterproof packing 101F on the surface that is in close contact with the upper casing 102. The waterproof packing 101F is also extended to the lower surface of the projecting portions 102A and 102B of the upper casing portion 102 and the portion in contact with the end surface of the central portion 102C, and is provided between the lower housing portion 101 and the upper housing portion 102. It is possible to prevent liquid from entering the space.

A hole 101G for inserting the leaf spring release rod 154 is provided on the side surface of the lower casing portion 101 along the front-rear direction. A duckbill-like valve packing (not shown) is inserted into the hole 101G, and the hole is closed when the leaf spring release rod 154 is removed. Further, a bottom 101 A of the lower housing part 101 is provided with a hole 101 K into which the injection part 104 is fitted to inject a chemical liquid into the chemical liquid bag 110.

The peripheral portion of the hole 101K realizes a waterproof function by fitting the injection portion 104, which is an elastic member fused to the chemical solution bag 110, and the lower housing portion 101.

Further, the lower casing portion 101 is provided with a concave portion 101H on the front side, which is a space into which a part of the puncture channel portion 30 is fitted when the puncture channel portion 30 is engaged with the drug solution storage and delivery unit 10. . Further, the lower casing portion 101 is provided with projections 101I and 101J protruding in opposite directions to guide the puncture flow path portion 30 so as to be slid and engaged with the medicinal solution storage / delivery portion 10 from the front direction. It is provided along.

The upper housing part 102 is provided with projecting parts 102A and 102B protruding in the front-rear direction so as to be continuous with the projecting parts 101I and 101J of the lower housing part 101 in the front-rear direction. The upper housing portion 102 is formed such that the central portion 102C sandwiched between the protrusion portions 102A and 102B is one step lower than the other portions in order to form the protrusion portions 102A and 102B.

In the upper housing portion 102, a concave portion 102D into which a convex portion 301C (FIG. 15) of the puncture flow channel portion 30 is fitted when the puncture flow channel portion 30 is engaged with the drug solution storage and delivery portion 10 is a predetermined position of the central portion 102C. Provided.

The chemical solution bag 110 as a reservoir is formed of a rectangular sheet 111 made of, for example, polyurethane, vinyl chloride, or polyethylene, as shown in FIG. As shown in FIG. 5 (A), the sheet 111 is a central portion in the longitudinal direction and is a portion (hereinafter also referred to as a central portion) 112 that becomes the bottom surface of the chemical solution bag 110 that is a flexible thermoplastic resin. At least three odd or more (five in the present embodiment) fold lines 113 and 114 are provided at equal intervals on both sides of the sheet. As a result, an even number of portions (hereinafter also referred to as folding portions) 115 and 116 having a predetermined width are formed on the sheet 111 between the adjacent folds 113 and 114, respectively.

Further, the sheet 111 has portions (hereinafter also referred to as end portions) 117 and 118 that are longer than half of the length in the longitudinal direction in the central portion 112 on the further end side than the folds 113 and 114 from the most ends in the longitudinal direction. Provided.

In this sheet 111, the folds 113 and 114 are alternately folded into a mountain fold and a valley fold so that the fold portions 115 and 116 overlap the center portion 112, and as shown in FIG. Part of the end side overlaps.

In the sheet 111, the overlapping portions of the end portions 117 and 118 are fused, and the edges in the width direction are fused. When the edge in the width direction of the sheet 111 is fused, the edge is fused so that the nozzle 105 that connects the space surrounded by the sheet 111 and the external space is sandwiched between the edges.

Also, at a predetermined position of the central portion 112 of the sheet 111, an injecting portion 104 having a rubber stopper (not shown) formed of, for example, synthetic rubber or the like is provided to inject the chemical solution into the chemical solution bag 110 from the outside. In this way, a chemical solution bag 110 as shown in FIG. 5C is formed.

The medical solution bag 110 formed in this way is folded so that the adjacent folding portions 115 and 116 are in contact with each other in a state where the medical solution is not filled, and the central portion 112 and the end portions 117 and 118 are Overlap.

Therefore, the chemical solution bag 110 is not crushed so that the central portion 112 and the end portions 117 and 118 are in contact with each other without leaving the chemical solution inside when the chemical solution filled therein is sent to the outside through the nozzle 105. Can be sent to the outside.

By the way, the conventional chemical solution bag is generally formed by fusing the edges of two films, and the chemical solution is injected into the space formed by the two films. As the distance approaches, the distance between the two films becomes shorter.

Therefore, in the conventional chemical solution administration device using the chemical solution bag, in the space where the chemical solution bag is stored, when the chemical solution is injected near the edge of the chemical solution bag, a useless space is formed in the portion where the chemical solution bag does not expand. Will be. Thus, the conventional drug solution bag has a problem in that the drug solution administration device is enlarged.

On the other hand, since the chemical solution bag 110 has the folding portions 115 and 116 in the longitudinal direction, the folding portions 115 and 116 separate the center portion 112 and the end portions 117 and 118 when the chemical solution is injected. It spreads in the direction (vertical direction).

Therefore, the chemical solution bag 110 can expand in the vertical direction even when it is near the edge of the chemical solution bag 110 when the chemical solution is injected by expanding the folding parts 115 and 116. In the space formed with the casing 102, when the chemical solution is injected, a wasteful space is not formed even in a portion near the edge of the chemical solution bag 110, and the chemical solution administration device 2 can be downsized. Yes, thus improving usability.

As shown in FIG. 6, the filter unit 120 is connected to a side surface of the upper lid 121 having an opening on the lower side and a space in the interior, and a nozzle 105 communicating the inner space and the chemical solution bag 110. A channel pipe 106 communicating with the delivery unit 130 is connected.

The filter unit 120 is provided with an air vent filter 122 that allows gas to pass but not liquid to close the opening of the upper lid 121. The air vent filter 122 is fixed between the upper lid 121 and the lower lid 123 that closes the opening of the upper lid 121 so as to be sandwiched between the O-rings 124 and 125 along the circumferential direction. The upper lid 121 and the lower lid 123 are in close contact with each other by, for example, ultrasonic fusion. The lower lid 123 is provided with a hole 123A penetrating in the vertical direction.

Thus, the filter unit 120 can discharge only the gas from the inner space of the upper lid 121 through the hole 123A provided in the lower lid 123 without discharging the chemical solution.

As shown in FIGS. 7, 8 A and 8 B, the delivery unit 130 is a valveless pump that does not have a valve, and is configured around a cylinder 131 and a piston 132.

Incidentally, although FIG. 7 shows a perspective view, for the convenience of explanation, a part that is originally hidden by making a part transparent is clearly shown. FIG. 8A is a cross-sectional view as viewed from above, and FIG. 8B is a cross-sectional view as viewed from the right side of the A1-A2 plane in FIG. 8A. A partial side view is shown in combination.

The cylinder 131 has a rectangular parallelepiped shape whose outer diameter is long in the left-right direction, and a cylindrical hole is drilled from the left side surface to the right direction around the central axis X that is a virtual straight line along the left-right direction. Thus, an internal space 131S is formed.

The inner space 131S is closed on the right side by a flat circular bottom surface 131A, surrounded by a cylindrical inner peripheral side surface 131B in the vertical direction or the front-rear direction, and only the left side is open. Incidentally, the inner diameter of the internal space 131S is about 0.6 [mm].

Further, the cylinder 131 has an inflow pipe 131C penetrating between the front side surface and the internal space 131S and an outflow pipe 131D penetrating between the rear side surface and the internal space 131S.

The inflow pipe 131C communicates with the flow path pipe 106 on the front side surface, and allows the chemical solution supplied from the chemical solution bag 110 via the filter unit 120 to flow into the internal space 131S.

Further, the inlet 131E, which is the end of the inflow pipe 131C on the inner space 131S side, is formed in a long hole shape that is short in the vertical direction and long in the horizontal direction.

The outflow pipe 131D communicates with the flow path pipe 107 on the rear side, and the chemical liquid flows out from the internal space 131S and is supplied to the valve body 108 (FIG. 3) via the flow path pipe 107.

Moreover, the outflow port 131F which is the edge part by the side of the internal space 131S of outflow pipe 131D is formed in the long hole shape short in the up-down direction and long in the left-right direction similarly to the inflow port 131E.

The piston 132 as a whole is formed in a columnar shape centered on the central axis X, and one end face port 132AH made of a round hole of a predetermined diameter is formed on the right flat end face 132A, and the outer peripheral side face 132B is also predetermined. One outer peripheral side port 132BH made of a round hole with a diameter is formed. In addition, a circulation pipe 132C that is bent in an L shape and communicates with the end surface port 132AH and the outer peripheral side surface port 132BH as the outer peripheral side surface port passes through the piston 132.

The outer diameter of the piston 132 is slightly smaller than the inner diameter of the internal space 131S of the cylinder 131. Therefore, when the piston 132 is inserted into the internal space 131S of the cylinder 131, the right end surface 132A is opposed to the bottom surface 131A of the cylinder 131, and the outer peripheral side surface 132B is in close contact with the inner peripheral side surface 131B of the cylinder 131. Let

The piston 132 forms a highly airtight space surrounded by the end surface 132A, the bottom surface 131A of the cylinder 131, and the inner peripheral side surface 131B in the internal space 131S. Hereinafter, this space is referred to as a storage space 131L.

Further, when an external force is applied in a predetermined direction, the piston 132 can move in the left-right direction within the cylinder 131, that is, in the direction along the central axis X, and in the cylinder 131 around the central axis X in the circumferential direction. Can be rotated. Hereinafter, the rotation direction around the central axis X is referred to as a clockwise direction or a counterclockwise direction depending on the rotation direction when viewed from the right side as shown in FIG. 8B.

Further, for convenience of explanation, in the following, the direction in which the outer peripheral side surface port 132BH is located with respect to the central axis X is defined as the direction of the piston 132, and the position of the piston 132 with respect to the direction along the central axis X (namely, the left-right direction) Called the position. Further, hereinafter, a position (corresponding to a so-called top dead center) when the piston 132 moves rightward in the cylinder 131 and the end surface 132A contacts the bottom surface 131A is referred to as a contact position. A position (corresponding to a so-called bottom dead center) when it is leftward from the contact position by a predetermined distance (for example, about 3 [mm]) is called a separation position.

Note that a lubricant such as silicon may be applied to the outer peripheral side surface 132B of the piston 132 and the inner peripheral side surface 131B of the cylinder 131 so as to improve the sealing performance and reduce the frictional force so that the sliding can be performed smoothly. . Further, an O-ring groove may be provided around the inlet 131E and the outlet 131F, and an O-ring having a small sliding resistance covered with Teflon (registered trademark of DuPont) may be installed.

Although the piston 132 basically closes the inlet 131E and outlet 131F of the cylinder 131 by the outer peripheral side surface 132B, the outer peripheral side port 132BH is connected to the inlet 131E or outlet 131F when facing forward or rearward. Let

Here, the inflow port 131E and the outflow port 131F include a location facing the outer peripheral side surface port 132BH when the piston 132 is in the contact position, and a location facing the outer peripheral side surface port 132BH when the piston 132 is in the separated position. The position and shape are determined so as to be a long hole connecting the two.

For this reason, the piston 132 is moved between the contact position and the separation position (hereinafter referred to as the piston movement range) along the central axis X while the outer peripheral side surface port 132BH faces the front direction or the rear direction. The outer peripheral side surface port 132BH and the inflow port 131E or the outflow port 131F can be kept connected at any position within the range.

That is, when the piston 132 is directed forward, the delivery unit 130 sequentially communicates from the inlet pipe 131C to the storage space 131L via the inlet 131E and the outlet pipe 132C at any position in the piston movement range. Can do.

Further, when the piston 132 is directed backward, the delivery unit 130 sequentially communicates from the storage space 131L to the outflow pipe 131D via the flow pipe 132C and the outflow port 131F at any position in the piston movement range. Can do.

Near the left end of the piston 132, a groove 132D having a predetermined depth that goes around the outer peripheral side surface 132B is formed, and an annular O-ring 133 is fitted into the groove 132D. The O-ring 133 is made of a resin material having elasticity, and is configured to maintain airtightness between the piston 132 and the cylinder 131.

A long and thin columnar column 134 is extended to the left on the left end surface of the piston 132. Further, a screw receiving portion 135 is attached to the left side of the column portion 134. That is, the piston 132, the column portion 134, and the screw receiving portion 135 are configured to move or rotate integrally in the internal space 131S of the cylinder 131.

The screw receiving portion 135 is formed in a rectangular parallelepiped shape that is elongated in the left-right direction as a whole, and has a shape penetrating vertically by making the inside hollow and omitting the upper side surface and the lower side surface.

In the screw receiving portion 135, a claw portion 135A as a piston-side protruding portion is erected outward in the vicinity of the right end of the side plate in the same direction as the outer peripheral side surface port 132BH of the piston 132 when viewed from the central axis X. .

On the other hand, a restriction portion 136 is attached to the cylinder 131 from the left side surface to the inner peripheral side surface 131B.

The restricting portion 136 is configured by an annular ring portion 136A serving as a substrate and two restricting

plates

136B and 136C each having an elongated plate shape.

The annular portion 136 A has an inner diameter substantially equal to the inner peripheral side surface 131 B of the cylinder 131, and is attached to the left side surface of the cylinder 131 so that the inner peripheral side surface 131 B and the inner side surfaces of each other are aligned. .

The restricting

plates

136B and 136C have their respective longitudinal directions aligned with the left-right direction, that is, the direction along the central axis X, and are located slightly below the front and rear sides of the inner surface of the annular portion 136A. Each is attached so as to protrude greatly from the annular portion 136A to the right. That is, the

restriction plates

136B and 136C are erected from the inner peripheral surface 131B to the central axis X in the internal space 131S.

Further, the

regulation plates

136B and 136C are arranged in a direction from the inner peripheral side surface 131B toward the central axis X, that is, in a short direction so that the screw receiving portion 135 is rotated integrally with the piston 132 and the column portion 134 so as to come into contact with the claw portion 135A. The length of is determined.

For this reason, the restricting portion 136 brings the restricting

plates

136B and 136C into contact with the claw portion 135A so that the rotation range of the screw receiving portion 135 and the piston 132 is about 180 ° from the front to the rear through the upper direction. The range (hereinafter referred to as the piston rotation range) can be regulated.

Further, the

regulation plates

136B and 136C define the length and the mounting position in the left and right direction so that the claw portion 135A moves in the left and right direction when the piston 132 moves in the piston movement range.

For this reason, the restricting portion 136 can restrict the rotation range of the screw receiving portion 135 and the piston 132 within the piston rotation range even when the piston 132 is in any position within the piston movement range.

Incidentally, the left end face plate of the screw receiving portion 135 is provided with a screw hole 135B penetrating in the left-right direction. A threaded portion 137A of the rotating threaded portion 137 is screwed into the threaded hole 135B.

The rotating screw portion 137 is configured around a screw portion 137A in which a thread groove is engraved on the peripheral side surface of a cylindrical column that is elongated in the left-right direction with the center axis X as the center, and is cylindrical from the screw portion 137A to the left. The relay part 137B is extended.

Further, the relay portion 137B of the rotary screw portion 137 is supported by a rotary screw support portion having a slide bearing (not shown) so that it can freely rotate while maintaining positions in the left-right direction, the front-rear direction, and the vertical direction.

Further, the threaded portion 137A of the rotating threaded portion 137 is configured so that a frictional force generated between the screw receiving portion 135 and the screw hole 135B (hereinafter referred to as a screwed frictional force) The dimensions, materials, and the like of each part are optimized so as to be higher than the frictional force generated between the side 131B (hereinafter referred to as the peripheral side frictional force).

On the other hand, a gear portion 137C made up of a bevel gear centered on the central axis X is attached to the left end of the relay portion 137B. The gear portion 137C meshes with the gear portion 138A of the rotation transmission portion 138.

The rotation transmitting portion 138 is configured around a central axis cylindrical relay portion 138B along the vertical direction, and a gear portion 138A made of a bevel gear similar to the gear portion 137C is attached to the lower end of the relay portion 138B. ing.

A driving magnet 138C made of a disk-shaped magnet is attached to the upper end of the relay portion 138B. Further, a rotation detection magnet 138D made of a small rectangular parallelepiped magnet is attached to one place on the outer periphery of the drive magnet 138C.

The driving magnet 138C is coupled to a power transmission magnet (described later) of the drive control unit 20 via a magnetic force. Further, the rotation transmitting unit 138 is supported by a support unit (not shown) so as to be able to rotate around a rotation axis along the vertical direction.

Therefore, when the power transmission magnet (described later) of the drive control unit 20 is rotated, the rotation transmission unit 138 rotates by transmitting the rotation driving force via the driving magnet 138C, and the gear unit 138A and The rotating screw portion 137 can be rotated by the meshing of the gear portion 137C.

In the above configuration, when the rotary screw part 137 is rotated via the rotation transmission part 138, the delivery part 130 rotates and moves the piston 132 in accordance with this, thereby causing the chemical liquid inflow operation and the outflow operation. I do.

As shown in FIG. 9A corresponding to FIGS. 8A and 8B, the delivery unit 130, when performing the inflow operation, first has the piston 132 in the contact position and facing backward. To do.

When the rotary screw portion 137 is rotated in the clockwise direction, the delivery portion 130 applies an external force in the rotational direction to the piston 132 via the screw receiving portion 135 due to the screw friction force generated between the screw portion 137A and the screw hole 135B. In addition, the claw portion 135A is brought into contact with the front regulation plate 136B by rotating about 180 ° clockwise.

Thereby, as shown in FIG. 9B, the delivery unit 130 connects the outer peripheral side surface port 132BH and the inflow port 131E with the piston 132 facing forward, and connects the inflow port 131E and the flow tube 132C from the inflow tube 131C. The outlet 131F is closed by the outer peripheral side surface 132B of the piston 132.

Further, when the rotary screw portion 137 continues to rotate in the clockwise direction, the delivery portion 130 cannot rotate due to the screw receiving portion 135 being restricted by the restriction plate 136B, and therefore the screw receiving portion 130 is screwed by the screw portion 137A and the screw hole 135B. An external force in the moving direction is applied to the piston 132 via the portion 135, and the claw portion 135A is moved to the left while sliding on the restricting plate 136B, that is, using the restricting plate 136B as a guide rail.

At this time, as shown in FIG. 9C, the delivery unit 130 gradually expands the volume of the storage space 131L as the piston 132 moves in the left direction to increase the negative pressure, and is supplied to the inflow pipe 131C. The chemical solution to be flowed into the storage space 131L.

Here, since the inflow port 131E is formed in a long hole shape, the delivery unit 130 can maintain the connection state between the outer peripheral side surface port 132BH and the inflow port 131E while the piston 132 moves over the piston movement range. It is possible to keep the chemical liquid flowing from the inflow pipe 131C into the storage space 131L.

Moreover, since the delivery part 130 can keep closing the outflow port 131F by the outer peripheral side surface 132B of the piston 132 at this time, the inflow of the chemical | medical solution from the said outflow port 131F side can be prevented.

Thereafter, as shown in FIG. 9 (D), the delivery unit 130 rotates the rotating screw part 137 clockwise a predetermined number of times, and at the stage where the piston 132 reaches the separated position, the rotating screw part 137 rotates clockwise. Stop rotation. As a result, about 1 [μl] of the chemical solution is stored in the storage space 131L.

As described above, when the rotary screw portion 137 is rotated clockwise, the delivery unit 130 rotates the piston 132 half a clockwise and then moves leftward as shown in FIGS. 9 (A) to (D). It can be moved and a chemical | medical solution can be poured in into the storage space 131L from the inflow pipe 131C.

In addition, when performing the outflow operation, the delivery unit 130, as shown in FIG. 10 (A) showing a state equivalent to FIG. 9 (D), has the piston 132 in the separated position and facing forward. To do.

When the rotary screw portion 137 is rotated counterclockwise, the delivery portion 130 causes an external force in the rotational direction to be exerted on the piston 132 via the screw receiving portion 135 by a screw friction force generated between the screw portion 137A and the screw hole 135B. And the claw portion 135A is brought into contact with the rear-side regulating plate 136C by rotating about 180 ° counterclockwise.

Thus, as shown in FIG. 10B, the delivery unit 130 connects the outer peripheral side surface port 132BH and the outlet 131F with the piston 132 facing rearward, and connects the flow pipe 132C and the outlet 131F from the storage space 131L. And the outflow pipe 131D are sequentially communicated with each other, and the inflow port 131E is closed by the outer peripheral side surface 132B of the piston 132.

Furthermore, since the screw receiving portion 135 is restricted by the restricting plate 136C and cannot be rotated when the rotating screw portion 137 is continuously rotated counterclockwise, the delivery portion 130 is screwed by screwing the screw portion 137A and the screw hole 135B. An external force in the moving direction is applied to the piston 132 via the receiving portion 135, and the claw portion 135A is moved to the right while sliding on the restricting plate 136C, that is, using the restricting plate 136C as a guide rail.

At this time, as shown in FIG. 10 (C), the delivery unit 130 gradually reduces the volume of the storage space 131L as the piston 132 moves in the right direction to increase the pressure, and stores in the storage space 131L. The chemical liquid being discharged is allowed to flow out to the outflow pipe 131D.

Here, since the outflow port 131F is formed in a long hole shape in the same manner as the inflow port 131E, the delivery unit 130 is connected to the outer peripheral side surface port 132BH and the outflow port 131F while the piston 132 moves over the piston movement range. Thus, the chemical solution can continue to flow out from the storage space 131L to the outflow pipe 131D.

Further, at this time, the delivery unit 130 can keep the inlet 131E closed by the outer peripheral side surface 132B of the piston 132, and thus can prevent the chemical solution from flowing out from the inlet 131E side.

Thereafter, as shown in FIG. 10D, the delivery unit 130 rotates the rotating screw unit 137 counterclockwise a predetermined number of times and reaches the piston 132 at the contact position, thereby counterclockwise the rotating screw unit 137. Stop rotating in the direction. Thereby, all the chemical | medical solutions in the storage space 131L flow out.

As described above, when the rotary screw portion 137 is rotated counterclockwise, the delivery unit 130 rotates the piston 132 half-clockwise counterclockwise as shown in FIGS. 10 (A) to (D). It is possible to cause the chemical solution to flow out from the storage space 131L to the outflow pipe 131D.

That is, when the rotary screw portion 137 is rotated in the clockwise direction, the delivery unit 130 causes the chemical solution to flow into the storage space 131L from the inflow pipe 131C, and when the rotary screw portion 137 is rotated in the counterclockwise direction, the storage space 131L. The chemical liquid can flow out from the inside to the outflow pipe 131D.

For this reason, the delivery unit 130 can function as a pump that intermittently delivers the chemical solution by alternately switching the rotation direction of the rotary screw unit 137 under the control of the drive control unit 20 (FIG. 2).

At this time, the delivery unit 130 can make the volume of the storage space 131L constant when the piston 132 is at the separation position, so that the inflow amount by one inflow operation (FIG. 9) and the one outflow operation (FIG. 9). The outflow amount according to 10) can be made constant.

For this reason, in the delivery part 130, the delivery speed of a chemical | medical solution can be kept constant by keeping the rotation speed of the rotation screw part 137 constant, and the change degree can be changed by changing the rotation speed of the rotation screw part 137. Accordingly, the delivery speed of the chemical solution can be changed.

Furthermore, because of the structure of the delivery unit 130, only one of the inflow pipe 131C or the outflow pipe 131D can be communicated with the storage space 131L at a time, and therefore the delivery section 130 communicates with both the inflow pipe 131C and the outflow pipe 131D at the same time. This prevents the back flow of the chemical solution and fluctuations in the delivery speed.

By doing so, it is possible to deliver a fixed amount of the chemical solution with a simple configuration without providing a check valve, and thus it is possible to realize a delivery unit 130 that satisfies the fixed amount of the chemical solution and miniaturization at the same time.

As shown in FIG. 3, the compression unit 150 includes a press plate 151, a support unit 152, and a plate spring 153. The holding plate 151 is a plate material having an area larger than the central portion 112 of the chemical solution bag 110 and is provided on the upper side of the chemical solution bag 110. The holding plate 151 is supported by a support portion 152 fixed to the lower casing portion 101 so as to be rotatable in a direction away from and approaching the chemical solution bag 110 around the connecting portions 151A and 152A formed of, for example, a hinge mechanism. The

The plate spring 153 is a plate material provided in a state of being bent in a substantially V shape between the holding plate 151 and the upper housing portion 102, and the plate portions that are bent in a substantially V shape and are opposed to each other are separated from each other. The force works in the direction to open (the direction to open). Therefore, when the leaf spring 153 is disposed between the holding plate 151 and the upper housing portion 102, the holding plate 151 is always pressed against the chemical solution bag 110 side with a constant force.

By the way, the compression portion 150 is a plate spring release rod between the holding plate 151 and the plate spring 153 through the hole 101G of the lower housing portion 101 before the chemical solution is injected into the chemical solution bag 110 (FIG. 4A). 154 is inserted. At this time, in the compression unit 150, the presser plate 151 can freely rotate without the plate spring 153 pressing the presser plate 151.

When the leaf spring release rod 154 is removed after the chemical solution is injected into the chemical solution bag 110, the compression portion 150 presses the holding plate 151 against the chemical solution bag 110 side. As a result, the pressing plate 151 sandwiches the chemical solution bag 110 with the lower housing 101 and the presser plate 151 applies a constant positive pressure to the chemical solution bag 110 (FIG. 4B).

Thereby, the compression unit 150 can discharge the bubbles to the outside via the filter unit 120 when bubbles are present in the chemical solution bag 110.

In addition, when the medical solution stored in the chemical solution bag 110 is sent out by the delivery unit 130, the compression unit 150 presses the chemical solution bag 110 in a direction to be crushed, so that the chemical solution stored in the chemical solution bag 110 is pushed out without leaving inside. Thus, it can be sent out.

[2-2. Configuration of drive control unit]
As shown in FIG. 11, the drive control unit 20 is formed in a substantially U-shape having a recess 20 A that matches the shape of the puncture flow channel portion 30 so that the puncture flow channel portion 30 is inserted from the front direction. Is done.

The drive control unit 20 is a space formed between an upper housing part 201 that is open on the lower side and has a space inside, and a lower housing part 202 that is screwed into the opening of the upper housing part 201. Are provided with a charging antenna 203, a substrate 204, a communication antenna 205, a rechargeable battery 206, a motor 207, a gear head 208, a power transmission magnet 209,

magnetic sensors

210 and 211, and the like.

The outer surface along the front-rear direction of the upper housing part 201 is provided with engagement receiving parts 201A to 201D that are grooves for engaging with the engagement parts 101B to E provided in the chemical solution storage and delivery part 10, respectively.

Also, on the upper surface of the upper housing part 201, a bolus switch 201E that is pressed down by the user when a certain amount of chemical solution is temporarily administered (bolus administration) is provided. The bolus switch 201E is provided at a position recessed from the upper surface of the upper housing portion 201, and can be prevented from being accidentally pressed by the user, for example, by turning over.

The lower casing 202 is provided with a waterproof packing 202A on the surface that is in close contact with the upper casing 201, and the upper casing 201 is screwed to the lower casing 202 via the waterproof packing 202A (not shown). Since it is screwed or ultrasonically fused, it is possible to prevent liquid from entering the internal space from between the upper casing portion 201 and the lower casing portion 202.

The charging antenna 203 is affixed on the upper surface of the lower housing | casing part 202, and the electricity supplied from the charger 4 (FIG. 21) mentioned later is received.

Further, on the upper surface of the lower housing section 202, a CPU (Central
A board unit 204 on which a communication antenna 205 for transmitting and receiving signals to and from an electrical circuit such as a processing unit (RAM), a random access memory (RAM), and a read only memory (ROM) and the controller 3 is disposed above the charging antenna 203. It is provided to overlap.

Furthermore, a rechargeable battery 206 is provided on the upper surface of the lower casing unit 202, which is charged by electricity supplied from the charging antenna 203 and supplies electricity to each unit during driving.

Further, the motor 207, the gear head 208, and the power transmission magnet 209 are provided on the upper surface of the lower casing unit 202 so as to overlap with each other in order from the top at a position facing the driving magnet 138C of the drug solution storage and delivery unit 10. A magnetic sensor 210 is provided on the upper surface of the lower housing unit 202.

The motor 207 rotates the power transmission magnet 209 via the gear head 208. As shown in FIG. 12, the power transmission magnet 209 faces the drive magnet 138C so as to have a polarity that attracts the drive magnet 138C in a state where the chemical storage / delivery unit 10 and the drive control unit 20 are in close contact with each other. To be placed.

When the power transmission magnet 209 is rotated by the motor 207 via the gear head 208, the power transmission magnet 209 rotates with its rotation while attracting the driving magnet 138C by magnetic force.

Accordingly, the motor 207 rotates the piston 132 by rotating the rotation transmission portion 138 and rotating the rotation screw portion 137 in a non-contact manner via the gear head 208, the power transmission magnet 209, and the driving magnet 138C. Move to.

By the way, since the motor 207 rotates the rotation transmission unit 138 in a non-contact manner through the magnetic force of the power transmission magnet 209 and the driving magnet 138C, it is determined whether or not the rotation transmission unit 138 rotates following the rotation of the motor 207. It needs to be detected. Therefore, the magnetic sensor 210 that detects that the rotation transmitting unit 138 is rotating is disposed on the circumference where the rotation detecting magnet 138D moves.

More specifically, after the magnetic sensor 210 detects the magnetic force of the rotation detection magnet 138D, it detects that the rotation transmitting unit 138 has made one rotation by detecting the magnetic force again.

In this manner, the magnetic sensor 210 can detect the rotation and movement of the piston 132 by detecting that the rotation transmitting unit 138 is rotating. Here, as an example, the number of rotations is detected in units of one rotation, but the number of magnetic sensors 210 may be increased to detect the number of rotations more finely.

Thus, as will be described in detail later, the microcomputer 220 (FIG. 21) is a magnetic sensor 210 provided in the same space formed by the upper housing portion 201 and the lower housing portion 202 and is a different space. It is possible to check the drive of the sending unit 130 provided in the space formed by the lower housing unit 101 and the upper housing unit 102 without contact.

Electricity is supplied from the rechargeable battery 206 to the puncture channel unit 30 on the front surface of the recess 20A that comes into contact with the upper casing unit 201 when the puncture channel unit 30 is in close contact therewith. A connector unit 212 for transmitting and receiving various signals is provided. As shown in FIGS. 13A and 13B, the connector portion 212 has a structure in which a waterproof rubber 212B covers the outside of the electrical connector portion 212A in which a plurality of spring connectors 212C for transmitting and receiving electricity and various signals are collected. It becomes.

Similarly, the connector part 350 (FIG. 15) of the puncture flow path part 30 connected to the connector part 212 also has a waterproof rubber outside the electric connector part 350A in which a plurality of connector parts 350C for transmitting and receiving electricity and various signals are collected. The structure is covered with 350B.

Thereby, in the drive control unit 20, when the connector unit 212 is connected to the connector unit 350, the waterproof rubber 212B and 350B can prevent the liquid from touching the electrical connector units 212A and 350B. In addition, when inserting the puncture flow path section 30 into the drug solution storage / delivery section 10 using one pin of the connector, the length is not contacted at the limit where insertion is permitted (when sufficient insertion is not performed). This pin is provided and connected to the ground potential on the puncture flow path section 30 side, and it is checked whether the potential of this pin is the ground potential or not on the drive control section 20 side. In this case, the insertion of the puncture channel 30 is monitored by displaying an alarm indicating that the puncture channel 30 is insufficiently inserted.

[2-3. (Configuration of puncture channel)
As shown in FIGS. 14 and 15, the puncture channel portion 30 is fitted in the space between the recess 101H and the recess 20A formed in a state where the drug solution storage / delivery unit 10 and the drive control unit 20 are engaged. It has an elongated shape. The puncture flow path part 30 is provided with each part in the internal space of the housing part 301 that forms the outer shell. 14A shows an external configuration, and FIG. 14B shows an internal configuration. Further, in FIG. 15, for convenience of explanation, a part is shown in cross section.

When the puncture flow path unit 30 is fitted to the drug solution storage and delivery unit 10, the housing unit 301 includes a bottom surface 301 A located on the same plane as the bottom surface 101 A of the lower housing unit 101 and the center of the upper housing unit 102. A bottom surface 301B located at a height facing and adjacent to the portion 102C.

The housing portion 301 is provided at a position where a convex portion 301C that fits into the concave portion 102D of the upper housing portion 102 when the puncture flow path portion 30 is fitted to the drug solution storage and delivery portion 10 faces the concave portion 102D in the bottom surface 301B. .

Further, the casing 301 includes a protrusion 101I of the lower casing 101 and a protrusion 102A of the upper casing 102, a protrusion 101J of the lower casing 101, and a protrusion of the upper casing 102. Guide grooves 301D and 301E that respectively engage with the portion 102B are formed on the side surfaces along the front-rear direction.

The casing 301 is provided with a recess 301Q on the upper surface 301F for hooking a user's finger when removing the puncture channel 30 from the drug solution storage / delivery unit 10 and the drive controller 20 that are fitted.

The casing 301 is curved from the upper surface 301F to the front surface 301G, and an angle adjustment mechanism 340, which will be described in detail later, is provided on the curved surface 301H.

In addition, the casing 301 is provided with a hole 301I at a position facing the valve body 108 of the chemical liquid storage / delivery section 10 in a state where the puncture flow path section 30 is fitted to the chemical liquid storage / delivery section 10. The nozzle 302 to be inserted is fixed so as to penetrate the hole 301I. The nozzle 302 is fixed without providing a gap with the hole 301I.

One end of the nozzle 302 is inserted into the valve body 108 in a state where the puncture flow path section 30 is fitted to the drug solution storage and delivery section 10 and communicates with the flow path pipe 107. The nozzle 302 is connected to a running water sensor 303 at the other end.

The flowing water sensor 303 is for detecting whether or not the passing chemical solution is flowing. For example, the thermistor is heated at a constant current to detect a temperature change of the thermistor due to the continuous flow of the chemical solution. In addition to the method used for the temperature sensor, the heating source and the temperature sensor are used separately. The heating source is a resistor, heater wire, semiconductor, and the temperature sensor is a thermo file, platinum resistor, semiconductor, etc. Things are adaptable.

The flowing water sensor 303 has a puncture channel needle 304 connected to the end opposite to the end to which the nozzle 302 is connected, and allows the nozzle 302 and the puncture channel needle 304 to communicate with each other. The puncture flow path needle 304 is bent so that one end side connected to the running water sensor 303 is folded back on the S-shape, is arranged along the front-rear direction therefrom, and reaches the bottom surface 301A on the other end side. The puncture channel needle 304 is made of a metal member, but is a 28 gauge hollow tube, for example, which can be easily bent.

The puncture channel needle 304 is fixed by a fixing portion 305 that protrudes inward from the housing portion 301 at a position immediately after being folded back on the S-shape.

The puncture flow path needle 304 is spirally wound with a part (hereinafter also referred to as an elastic portion) 304A on the front side from the position fixed to the fixing portion 305. The elastic portion 304A is extendable in the front-rear direction.

The puncture channel needle 304 has a sharply sharp shape at a tip portion (hereinafter also referred to as a tip portion) 304B that is bent so as to reach the bottom surface 301A.

The puncture flow path needle 304 having such a shape sends the drug solution flowing from the flowing water sensor 303 to the outside through the inner space from the distal end portion 304B.

The puncture channel needle 304 is covered with, for example, the sheath portion 310 from the distal end portion 304B to the elastic portion 304A.

The sheath portion 310 is made of, for example, Teflon (registered trademark of DuPont) (polytetrafluoroethylene) or polyethylene, and is made of a flexible sheath 311 and, for example, Teflon (registered trademark of DuPont), polyolefin, or polyurethane. It is composed of an elongated portion 312 that is soft and has a characteristic (permanent deformation, plastic deformation) that maintains the shape as it is once deformed and does not return to the original shape. Examples of the material that is soft and easily deformable and has an irreversible property as the extending portion 312 include a material that is crosslinked by ultraviolet rays at a high temperature such as a heat shrinkable tube. Polyolefin, Teflon (registered by DuPont) Trademark), silicon, polyvinyl chloride, polyvinylidene fluoride, and the like can be used.

The sheath 311 covers most of the puncture channel needle 304 from the distal end 304B to the front of the elastic portion 304A, and is not fixed to the puncture channel needle 304.

The extending portion 312 covers the puncture channel needle 304 from a position overlapping one end side of the elastic portion 304A side of the sheath 311 to just before the elastic portion 304A, and one end on the fixed portion 305 side is the puncture channel needle. The other end is fixed to the sheath 311. The extending portion 312 is fixed so as to seal the gap between the puncture flow path needle 304 and the sheath 311 along the circumferential direction so that the liquid does not leak from the gap at both fixed ends.

A caulking 306 that fixes the puncture flow path needle 304 and the sheath 311 together is provided at a predetermined position closer to the distal end portion 304B than the elastic portion 304A of the puncture flow path needle 304. The caulking 306 is made of a material that deforms when a certain force is applied, such as aluminum or copper.

The caulking 306 is crushed from the left and right direction after the puncture flow path needle 304 and the sheath 311 are inserted into the ring hole from the state of the ring shape, and a part of the vertical direction overlaps, and the puncture flow path needle 304 and the sheath 311 are overlapped. Tighten and fix. Thereby, the sheath 311 is fixed so as not to slip with respect to the puncture flow path needle 304. The caulking 306 is bonded to the sheath 311 and does not leave the sheath 311 even when the caulking 306 is loosened.

The puncture flow path part 30 is provided in front of the caulking 306 and a movement restricting part 307 at a position away from the caulking 306 by a predetermined distance. As will be described later in detail, the predetermined distance is a distance at which the puncture flow path needle 304 and the sheath 311 protrude from the bottom surface 301A of the housing 301, that is, a depth at which the puncture flow path needle 304 and the sheath 311 are punctured to the user. It is the same distance as the distance, and is set to 10 mm in the present embodiment. The movement restricting portion 307 is fixed to the housing portion 301 and is arranged so that the puncture flow path needle 304 and the sheath portion 310 can be inserted into a hole provided in the center without contacting.

The puncture flow path section 30 is provided with a puncture mechanism 320 at a position behind the caulking 306 and ahead of the extension section 312. The puncture mechanism 320 includes a fixed plate 321, a spring 322, a support plate 323, and a pressing portion 324.

The fixing plate 321 is fixed to the housing part 301 and is arranged so that the puncture flow path needle 304 and the sheath part 310 can be inserted into a hole provided in the center without contact.

A spring 322 is disposed in front of the fixed plate 321. The spring 322 is arranged so as to pass through the inner space without contact between the puncture flow path needle 304 and the sheath portion 310, and is arranged in a state where it is sandwiched between the fixed plate 321 and the support plate 323 and compressed more than the natural length. Is done.

The support plate 323 is arranged so that the puncture flow path needle 304 and the sheath portion 310 are inserted without contacting each other, and is a surface on the opposite side to the surface where the spring 322 is in contact with the puncture flow path needle 304 and the sheath portion. The push portion 324 is supported below 310. The support plate 323 is held so as not to move forward by the puncture release mechanism 330 at a position lower than a position where the pressing portion 324 is supported on the same surface as the surface supporting the pressing portion 324.

As shown in FIG. 16, the pressing portion 324 has a substantially cylindrical shape, and has a negative shape (one character type) whose tip is long in the vertical direction and short in the horizontal direction. The pressing portion 324 is supported by the support plate 323 so that the tip is located between members overlapping on the lower side of the portion of the caulking 306 extending in the vertical direction.

The puncture release mechanism 330 includes a limiting portion 331, a spring 332, and an actuator 333.

The restricting portion 331 has a portion extending in the front-rear direction and a portion extending in the up-down direction so that the cross section has a substantially L shape, and is provided near the center of the portion extending in the front-rear direction. The rotary shaft 331A is held rotatably. The restricting portion 331 is disposed so as to support the support plate 323 with the surface on the rotating shaft 331A side of the portion extending in the vertical direction, and restricts the support plate 323 from moving in the forward direction.

The restriction portion 331 has a spring 332 connected to the lower surface on the front side of the rotation shaft 331A of the portion extending in the front-rear direction, and the protrusion 333A of the actuator 333 is in contact with the upper surface on the rear side of the rotation shaft 331A.

The spring 332 has one end connected to the restricting portion 331 and the other end connected to the bottom surface 301B side of the housing portion 301, and is arranged in a state in which a force is always applied in the direction of contraction.

The actuator 333 is configured to move the protruding portion 333A in the front-rear direction when electric power is supplied, and is disposed in a state where the protruding portion 333A is in contact with the limiting portion 331.

The spring 322 is sandwiched between the fixed plate 321 and the support plate 323 and compressed more than the natural length, the limiting portion 331 is in contact with the support plate 323, and the projection 333A of the actuator 333 is disposed in contact with the limiting portion 331. The state is also referred to as an initial state (FIGS. 15 and 17A). In FIG. 17, for convenience of explanation, the puncture flow path needle 304 and the sheath 311 are illustrated in a straight state that is not bent, but in reality, a part thereof is bent as described above.

In the initial state, when the actuator 333 is driven and the protrusion 333A is moved backward to release the restricting part 331 from the protrusion 333A, the restricting part 331 is rotated by the force of returning to the natural length of the spring 332 It is rotated counterclockwise around the shaft 331 A and moves away from the support plate 323.

In the puncture mechanism 320, when the restricting portion 331 is separated from the support plate 323, the contracted spring 322 extends to return to the natural length and pushes the support plate 323 and the pressing portion 324 in the forward direction. The pushing portion 324 pushed in the forward direction pushes the caulking 306 forward together with the puncture channel needle 304 and the sheath 311 until the caulking 306 comes into contact with the movement restricting portion 307.

At this time, the caulking 306 moves in the forward direction while sandwiching the puncture channel needle 304 and the sheath 311 along the caulking guide 308 in which the upper portion of the portions extending in the vertical direction overlaps on the upper side.

By the way, the cross section of the caulking guide 308 has a U-shape with an opening at the bottom, and the caulking 306 fits from the direction in which the caulking guide 308 is opened in the overlapping portion on the upper side. Is retained.

When the caulking 306 moves in the forward direction, the elastic portion 304A of the puncture channel needle 304 is extended (FIG. 17B). The puncture flow path needle 304 and the sheath 311 protrude from the bottom surface 301A of the housing 301, and the distal end 304B punctures the user and enters the user's body together with the sheath 311.

In the puncture mechanism 320, the spring 322 continues to extend even after the caulking 306 comes into contact with the movement restricting portion 307, and the tip of the pressing portion 324 enters between the members overlapping below the caulking 306. At this time, the pusher 324 opens the overlapping members below the caulking 306 on both sides, and loosens the tightening of the caulking 306 with respect to the puncture channel needle 304 and the sheath 311.

When the tightening by the caulking 306 is loosened, the fixation by the caulking 306 to the puncture channel needle 304 is released. Then, in the puncture channel needle 304, the elastic portion 304A contracts to the natural length, and the distal end portion 304B returns to the initial position inside the bottom surface 301A.

At this time, in the sheath portion 310, the sheath 311 is fixed to the caulking 306 and cannot move, so the extension portion 312 having one end fixed to the puncture channel needle 304 extends as the elastic portion 304A contracts.

The sheath portion 310 is maintained in a state in which the distal end portion of the sheath 311 protrudes from the bottom surface 301A because the elongated portion 312 that extends at one end does not return to the original shape (FIG. 17C).

In this way, when puncturing the user, the puncture channel section 30 punctures with the metal puncture channel needle 304 having a sharp tip 304B, and then inserts only the flexible sheath 311 into the body. Subsequently, the puncture channel needle 304 made of metal can be returned to the outside of the body.

Therefore, the medicinal solution administration device 2 does not leave the metal puncture channel needle 304 in the body while the user is using it, and can continue to insert only the flexible sheath 311 into the body. It is possible to reduce pain and discomfort to the user, thus improving usability.

On the other hand, in the conventional drug solution administration device, one end of the sheath is connected to the needle through a packing, and after the needle and the sheath are punctured into the skin, the sheath is inserted into the packing portion when the needle is pulled out of the body. It was made to slide and stay in that position.

Therefore, in the conventional drug solution administration device, the gap between the needle and the sheath is sealed with the packing, so that the drug solution leaks, or when the seal is strengthened, the friction between the needle and the packing increases and the needle reaches a sufficient depth. There was a possibility not to sting.

On the other hand, since the medicinal solution administration device 2 is fixed without providing a gap with the puncture channel needle 304 at one end of the extending portion 312, the medicinal solution does not leak. In addition, there is no hindrance to the puncturing operation due to the friction between the packing and the needle.

By the way, the puncture flow path section 30 (FIGS. 14 and 15) is forward of the movement restricting section 307 and on the curved surface 301H of the housing section 301, the angle at which the puncture flow path needle 304 and the sheath 311 project with respect to the bottom surface 301A ( Hereinafter, an angle adjustment mechanism 340 for adjusting the projection angle is also provided. Since the bottom surface 301A is in contact with the user's skin, the protruding angle is the same as the angle of the puncture flow path needle 304 and the sheath 311 with respect to the user's skin (hereinafter also referred to as the puncture angle).

As shown in FIG. 18, the angle adjustment mechanism 340 is supported by a support portion 341 made of an L-shaped column whose one end is fixed to the housing portion 301. The support portion 341 is a concentric circular shape at the end surface arranged to be orthogonal to the left-right direction on the side opposite to the one end fixed to the housing portion 301, and a plurality of (four in this embodiment) concave portions at a predetermined angle. 341A is provided. The concave portion 341A is provided at a position where the puncture angle of the puncture channel needle 304 and the sheath 311 is 20 ° to 90 °, as will be described in detail later.

The angle adjusting mechanism 340 is provided with a central portion 342 having a convex portion 342A projecting so as to be concentric with the concave portion 341A and fitted into the concave portion 341A at a position facing the end surface of the support portion 341. The central portion 342 is supported by the support portion 341 at a position where the protruding convex portion 342A fits into the concave portion 341A while being pressed toward the support portion 341 by the screw 345 through the spring 343 and the spring pressing plate 344.

The central portion 342 is provided with a shaft portion 346 in a direction orthogonal to the rotation axis when the center portion 342 rotates. The shaft portion 346 has a cylindrical shape, one end is connected to the holding portion 347 that holds the puncture channel needle 304 and the sheath 311, and the other end is connected to the knob portion 348 that is held when the angle is adjusted by the user. Is done.

The holding portion 347 is a tube having an inner diameter that is thicker than the outer shape of the sheath 311, and the puncture flow path needle 304 and the sheath 311 are inserted therethrough, and the puncture flow path needle 304 and the sheath 311 are held without being fixed.

As shown in FIG. 19, the knob portion 348 includes a knob 348A held by the user and a knob support portion 348B that supports the knob 348A. The knob portion 348 is placed so that both ends of the knob support portion 348B are hooked on rail portions 301K and 301M whose left and right sides of the opening 301J provided on the curved surface 301H of the housing portion 301 are L-shaped in cross section. The

The knob support portion 348B is placed so as to be sandwiched between the housing portion 301 and the panel portion 349 provided on the curved surface 301H of the housing portion 301. The panel portion 349 opens so that the knob 348A can move in a direction along the curved surface 301H (hereinafter also referred to as a curved direction), and has a shape that is longer in the curved direction than the rail portions 301K and 301M. is doing.

A waterproof packing 348C is provided on the edge of the upper surface of the knob support portion 348B, and prevents liquid from entering the housing portion 301 from between the knob support portion 348B and the panel portion 349.

In the angle adjusting mechanism 340 having such a configuration, the holding portion 347 is rotated according to the rotation of the shaft portion 346 around the center portion 342 when the knob portion 348 is moved in the bending direction by the user. .

Accordingly, as shown in FIGS. 20 (A) and 20 (B), the angle adjusting mechanism 340 sets the protrusion angle of the puncture flow path needle 304 held by the holding portion 347 and the bottom surface 301A of the sheath 311 to 20 ° to 90 °. Change in range. 20A shows a case where the protrusion angle is 90 °, and FIG. 20B shows a case where the protrusion angle is 20 °.

That is, the angle adjusting mechanism 340 can change the puncture angle of the puncture flow path needle 304 and the sheath 311 with respect to the user's epidermis arranged in parallel with the bottom surface 301A in the range of 20 ° to 90 °. The puncture flow path needle 304 and the sheath 311 are set so that the tip 304B does not come out of the bottom 301A when the distance between the tip 304B and the bottom 301A changes depending on the puncture angle.

Note that the distal end portion 304B of the puncture channel needle 304 and the distal end of the sheath 311 are arranged so as to close the opening 301N provided in the bottom surface 301A and come into contact with the outer periphery of the sheath 311. Held by the unit 309.

The tip holding portion 309 is fitted to an L-shaped rib provided inside the bottom surface 301A, and both sides are shifted in the front-rear direction along the inside of the front surface 301G and the back surface 301V of the 301. Due to the flexibility, even if the distal end portion 304B of the puncture flow path needle 304 and the distal end of the sheath 311 are moved to the angle adjusting mechanism 340, they can follow it and continue to close the opening 301N. Accordingly, liquid can be prevented from entering the housing portion 301.

The tip holding portion 309 includes an air vent filter 309A that covers the tip portion 304B of the puncture channel needle 304 and the tip of the sheath 311 at a position further ahead of the tip portion 304B of the puncture channel needle 304. Provided.

Therefore, the air vent filter 309A can discharge only the air present in the puncture channel needle 304 to the outside without leaking the drug solution flowing through the puncture channel needle 304 before use by the user. .

Thus, in the drug solution administration device 2, the angle adjustment mechanism 340 can change the protrusion angle of the puncture flow path needle 304 and the bottom surface 301A of the sheath 311 with respect to the bottom surface 301A within a range of 20 ° to 90 ° according to the operation of the user.

By the way, the human body has skins such as epidermis and dermis from about 1.5 mm to 4 mm from the body surface, and there is subcutaneous tissue at a depth of about 4 mm to 9 mm from the body surface inside, and further inside Have muscles.

For example, when insulin is administered from the outside, it is generally administered to a subcutaneous tissue at a depth of about 4 mm to 9 mm from the surface in consideration of burden on the user, pain, absorption rate of insulin, and the like.

However, although the depth of the subcutaneous tissue varies depending on individual differences such as its position and age, physique, gender, etc., since conventional drug solution administration devices puncture a fixed distance at a fixed puncture angle, for some users Insulin could not be administered to the subcutaneous tissue.

In contrast, the medicinal-solution administration device 2 can change the puncture angle of the puncture flow path needle 304 and the sheath 311 with respect to the user's epidermis within the range of 20 ° to 90 ° by the angle adjusting mechanism 340. By adjusting, it is possible to puncture to an arbitrary depth, and it is possible to reliably puncture the subcutaneous tissue that is optimal for all users. In recent years, by administering a drug solution to the dermis layer, it is possible to obtain the same medicinal effect with a small amount of drug solution compared to when administered subcutaneously, and therefore it is possible to set the puncture distance to the dermis. Thus, the medicinal solution administration device 2 can improve usability.

By the way, when the drive control unit 20 is in close contact with the housing unit 301, the connector unit 350 is adhered to the hole 301P provided at a position facing the connector unit 212 of the drive control unit 20 without a gap. As shown in FIGS. 13A and 13B, the connector portion 350 covers the outside of the electrical connector portion 350A in which a plurality of connector portions 350C for transmitting and receiving electricity and various signals are collected with a waterproof rubber 350B. Constructed.

Thus, the medicinal solution administration device 2 includes the puncture channel unit 30 provided with the puncture channel needle 304 for puncturing the user's skin, the medicinal solution storage and delivery unit 10 provided with the medicinal solution bag 110 for storing the medicinal solution, and the delivery. The drive control unit 20 provided with the motor 207 for operating the unit 130 and the substrate unit 204 is provided separately.

Therefore, in the drug solution administration device 2, for example, even when puncture fails or when inflammation occurs at the puncture site, it is only necessary to replace the puncture flow path section 30 and it is easy to use.

On the other hand, in the conventional liquid medicine administration device, since the needle for puncturing the user's skin, the liquid medicine bag for storing the liquid medicine, the motor, etc. are all provided in the same housing, for example, when puncture fails Had to replace the entire device, which was not only convenient, but also increased the economic burden.

[3. (Circuit configuration of chemical solution administration system etc.)
Next, the circuit configuration and functional configuration of the drug solution administration system 1 will be described with reference to FIG.

The controller 3 includes a microcomputer 361, a battery 362, a battery monitoring unit 363, a mode switch 364, a numerical value setting switch 365, a display unit 366, a transmission unit 367, a reception unit 368, and a communication antenna 369.

The microcomputer 361 is a computer including a CPU, a RAM, a ROM, and the like. The CPU reads and executes a basic program stored in the ROM and executes the overall control, and the CPU is stored in the ROM. Various processes are executed by reading various programs into the RAM and executing them.

The battery 362 supplies power to each unit. The battery monitoring unit 363 monitors the presence / absence and remaining amount of the battery 362 and notifies the microcomputer 361 of it.

The mode switch 364 is a switch for setting a basal mode in which a chemical solution is continuously administered for a long time and a bolus mode in which a chemical solution is temporarily administered. The numerical value setting switch 365 is a switch for setting the dose per hour and the administration time of the drug solution.

The microcomputer 361 displays the contents corresponding to the operation on the mode switch 364 and the numerical value setting switch 365 on the display unit 366 and transmits a signal indicating the contents to the drug solution administration device 2 via the transmission unit 367 and the communication antenna 369. To do.

In addition, when the microcomputer 361 receives the signal transmitted from the medicinal solution administration device 2 via the communication antenna 369, the microcomputer 361 acquires the signal via the receiving unit 368, and displays a content corresponding to the signal such as an occlusion alarm or a drive unit abnormality. In addition to notifying the user by displaying on 366, processing corresponding to the content is executed.

On the other hand, in the drug solution administration device 2, the electric circuit is operated by the power supply supplied from the rechargeable battery 206, and the microcomputer 220 provided in the drive control unit 20 performs overall control.

The microcomputer 220 is a computer including a CPU, a RAM, a ROM, and the like. The CPU reads and executes a basic program stored in the ROM and executes the overall control, and the CPU is stored in the ROM. Various processes are executed by reading various programs into the RAM and executing them.

The microcomputer 220 receives the administration time and the dose which are set in advance by the controller 3 and is stored in the RAM by the communication antenna 205 and the reception unit 222, and operates each part according to the administration time and the dose. Alternatively, each unit is operated directly according to the dose received from the controller 3 via the receiving unit 222.

Further, the microcomputer 220 operates the flowing water sensor 303 in synchronization with the liquid feeding of the delivery unit 130 to monitor whether the administration is normally delivered, and monitors whether the delivery unit 130 is operating as controlled by the magnetic sensor 210. If it is determined that there is an abnormality, the occurrence of a blockage, a drive unit abnormality, or the like is transmitted to the controller 3.

When administering a drug solution to a user, specifically, the bolus administration time and dose, and the basal administration time and dose are set in the controller 3 and transmitted to the drug solution administration device 2, thereby the drug solution administration device. 2 is set. In addition, an amount of the chemical solution corresponding to the set content is injected into the chemical solution bag 110 so that bubbles do not enter the chemical solution. Next, the puncture angle of the drug solution administration device 2 is adjusted by causing the user to operate the filling angle adjustment mechanism 340 under the guidance of the doctor, and the drug solution administration device 2 is attached to the user via the application unit 103.

In this state, when the puncture execution signal is supplied from the controller 3, the microcomputer 220 confirms whether or not the puncture flow path unit 30 is connected to the drive control unit 20 by connecting the

connector units

212 and 350. The microcomputer 220 drives the puncture release mechanism 330 to puncture the user with the puncture channel needle 304 and the sheath 311.

Subsequently, the microcomputer 220 sends a prescribed amount of liquid to fill the cavity in the sheath punctured by the living body. Specifically, the microcomputer 220 monitors whether or not the basal administration time or the bolus administration time stored in advance in the RAM has been reached, and administers a drug solution of a set dose when any administration time is reached. . Further, when the microcomputer 220 receives a bolus administration instruction from the controller 3, the microcomputer 220 immediately administers the received dose of drug solution. In any case, the microcomputer 220 administers the drug solution into the user's body by rotating the motor 207 and driving the delivery unit 130 in order to administer the drug solution at the set drug solution dosage and administration speed.

At this time, in the drug solution administration device 2, the drug solution stored in advance in the drug solution bag 110 via the injection unit 104 is used via the filter unit 120, the delivery unit 130, the running water sensor 303, the puncture channel needle 304, the sheath 311, and the like. It is administered to the body of a person.

During the administration of the chemical solution, the microcomputer 220 monitors the rotation speed of the motor 207 via the encoder 223 and detects whether or not the chemical solution is flowing via the flow detection control unit 224. The flow detection control unit 224 heats the thermistor of the flowing water sensor 303 and monitors the temperature change of the thermistor.

Further, the microcomputer 220 detects whether or not the sending unit 130 is driven based on the magnetic force detected by the magnetic sensor 210.

The microcomputer 220 performs again when the motor 207 is not rotating normally, when the delivery unit 130 is not normally driven, or when no chemical is flowing, and when the state does not change, Each unit is stopped, and a message such as a blocking alarm is transmitted to the controller 3 via the transmission unit 221 and the communication antenna 205.

When charging the rechargeable battery 206, the microcomputer 220 controls the receiving / charging circuit 225 to receive the electricity supplied from the charger 4 through the charging antenna 203 to charge the rechargeable battery 206. The rechargeable battery 206 is provided with a battery safety circuit unit 226. The battery safety circuit unit 226 monitors overcharge during charging and temperature change, prevents overcharge and thermal runaway, and prevents overdischarge during use. .

The charger 4 includes an outlet 401, an AC / DC converter 402, a high frequency converter 403, and a transmission antenna 404. The charger 4 converts alternating current sent from the outlet 401 into direct current by the AC / DC converter 402, converts it to high frequency by the high frequency conversion unit 403 for transmission by the transmission antenna 404, and then passes through the transmission antenna 404. Then, electric energy is transmitted to the drug solution administration device 2.

Therefore, in the drug solution administration device 2, the drug solution storage and delivery unit 10 including the drug solution bag 110 and the puncture channel unit 30 including the puncture channel needle 304 and the sheath 311 are used only once from the hygiene viewpoint that the drug solution is used. On the other hand, the drive control unit 20 that does not use the chemical solution can be used many times by attaching and detaching the chemical solution storage and delivery unit 10 and the puncture flow path unit 30. At this time, since the rechargeable battery 206 of the drive control unit 20 is charged by the charger, it can be used multiple times.

[4. Other Embodiments]
In the embodiment described above, the screw friction force generated between the screw portion 137A of the rotary screw portion 137 and the screw hole 135B of the screw receiving portion 135 is optimized by optimizing the dimensions and materials of each portion. The case where the peripheral side frictional force generated between the outer peripheral side surface 132B and the inner peripheral side surface 131B of the cylinder 131 is increased is described.

However, the present invention is not limited to this. For example, the screw friction force is applied to the peripheral side surface friction by urging the screw portion 137A of the rotating screw portion 137 to the screw hole 135B of the screw receiving portion 135 using an urging means such as a spring. You may make it raise rather than power.

Further, in the above-described embodiment, the case where the rotation screw portion 137 is supported by the rotation screw support portion (not shown) so that the rotation screw portion 137 can freely rotate while maintaining the positions in the left-right direction, the front-rear direction, and the vertical direction has been described.

However, the present invention is not limited to this, and the rotating screw portion 137 can be rotated freely while maintaining positions in the left-right direction, the front-rear direction, and the up-down direction by a rotating screw support portion formed of various known mechanisms or combinations thereof. May be supported.

[4-1. Other Embodiment 1]
For example, as shown in FIG. 22 and FIG. 23 corresponding to FIG. 7 and FIG. 8, a sending unit 630 that replaces the sending unit 130 can be configured.

Compared with the delivery unit 130 of FIG. 7, the delivery unit 630 includes a screw receiver 635 and a rotary screw 637 that replace the screw receiver 135 and the rotary screw 137, and further includes a relay gear 638 and a rotary screw support 640. Although the point which has is different, it is comprised similarly about another part.

As shown in FIG. 24, the screw receiving portion 635 has a claw portion 635A and a screw hole 635B similar to the claw portion 135A and the screw hole 135B of the screw receiving portion 135, and an annular mounting portion on the inner surface side of the left side plate. 635C is erected.

A spring 635D made of a coil spring is attached to the outer periphery of the attachment portion 635C. The spring 635D is wound in the right direction, and a cap 635E is attached to the right end thereof. The cap 635E is attached to the spring 635D by an annular 635EA similar to the attachment portion 635C, and a protrusion 635EB protruding leftward is formed at the center of the right side surface.

The spring 635D is attached to the screw receiving portion 635 in a state extended from the natural length. Incidentally, the spring coefficient, the number of turns, the pitch, and the like of the spring 635D are appropriately selected so that the natural length is not returned even when the piston 132 is at the separation position and is shortened the most.

In the rotating screw portion 637, a ruby bearing 637AB is embedded in the right end portion of the screw portion 637A corresponding to the screw portion 137A of the rotating screw portion 137. The ruby bearing 637AB is configured to receive the protrusion 635EB of the cap 635E by forming a recess in the center portion of the right side surface.

Therefore, regardless of the position of the piston 132, the spring 635D applies an elastic force that always tries to return to the natural length, that is, shortens, and causes the screw portion 637A of the rotary screw portion 637 to move to the left via the cap 635E. Since the biasing is performed, the screw friction force between the screw portion 637A and the screw hole 635B can be increased.

As described above, in the delivery portion 630, the screw friction force is made higher than the circumferential friction force by urging the screw portion 637A of the rotating screw portion 637 to the screw hole 635B of the screw receiving portion 635 by the elastic action of the spring 635D. Can do.

Incidentally, the rotating screw portion 637 is provided with a gear portion 637C made of a spur gear instead of the gear portion 137C made of a bevel gear of the rotating screw portion 137 of FIG. The gear portion 637C meshes with the gear portion 638A of the relay gear 638.

In the relay gear 638, a gear portion 638A made of a spur gear is attached to one end of a cylindrical columnar portion 638B, and a gear portion 638C made of a bevel gear is attached to the other end. The gear portion 638 C meshes with the gear portion 138 A of the rotation transmission portion 138, similarly to the gear portion 137 C of the rotation screw portion 137.

Thus, the relay gear 638 can be rotated by transmitting the rotational driving force from the rotation transmitting portion 138, and the rotational driving force can be transmitted to the rotating screw portion 637 to be rotated.

On the other hand, the rotating screw support portion 640 (FIG. 23) is configured around a plate-like substrate 641 that faces the plate surface in the left-right direction. The substrate 641 has

holes

641A and 641B drilled in two places, and

resin bearings

642 and 643 are fitted in the

holes

641A and 641B, respectively.

In the

holes

641A and 641B, the relay portion 637B of the rotary screw portion 637 and the columnar portion 638B of the relay gear 638 are inserted through

bearings

642 and 643, respectively.

A separation plate 644 is attached to the left side of the substrate 641. The separation plate 644 has a shape in which a plate-like member is bent so as to have a U-shaped cross section, and a bottom portion 644A substantially parallel to the substrate 641 is formed at a predetermined distance from the substrate 641 in the left direction. Has been.

A hole 644B is formed in a portion corresponding to the hole 641A in the bottom 644A, that is, on the left side of the hole 641A.

Thrust ball bearings

645 and 646 are respectively attached to the left and right sides of the hole 644B, and a disc 637D is in contact with the left side of the thrust ball bearing 646.

With this configuration, the rotating screw support portion 640 can support the rotating screw portion 637 so that it can rotate smoothly without displacing its position in any of the left-right direction, the front-rear direction, and the up-down direction.

[4-2. Other Embodiment 2]
Further, for example, as shown in FIGS. 25 and 26 corresponding to FIGS. 7 and 8 and FIGS. 22 and 23, a sending unit 730 may be configured in place of the sending

units

130 and 630.

Compared with the delivery unit 630 of FIG. 23, the delivery unit 730 has a screw receiving unit 635, a screw receiving unit 135 instead of the screw receiving unit 635, the rotating screw supporting unit 640, a rotating screw supporting unit 740, and a rotating screw supporting unit 740. In addition, although the point of having a spring 735 is different, other parts are configured similarly.

In the rotating screw portion 737, the ruby bearing 637AB (FIG. 24) is omitted from the rotating screw portion 637 of FIG. 23, and the screw portion 737A configured similarly to the screw portion 637A, the relay portion 637B, the gear portion 637C, and the disc 637D. , Relay portion 737B, gear portion 737C and disk 737D, and further, nylon washer 737E.

Further, a nylon washer 737E is sandwiched between the left side surface of the screw receiving portion 135 and the gear portion 737C of the rotating screw portion 737 so as to leave a space so as not to contact the periphery of the screw portion 737A and the relay portion 737B. Thus, the spring 735 which consists of a coil spring is pinched | interposed in the state shortened from natural length.

Incidentally, the spring 735 is in a state of being contracted from the natural length even when the piston 132 is in the abutting position and is most extended in the right direction, and is not completely shortened even when the piston 132 is in the separated position. The spring coefficient, the number of turns, etc. are selected as appropriate.

Therefore, the spring 735 always applies an elastic force to return to the natural length regardless of the position of the piston 132, that is, to extend and urge the screw portion 737A of the rotating screw portion 737 to the left. As in the case of the delivery portion 630, the screw friction force between the screw portion 737A and the screw hole 135B can be increased.

As described above, in the delivery portion 730, the screw friction force is made higher than the peripheral side friction force by urging the screw portion 637A of the rotary screw portion 637 to the screw hole 135B of the screw receiving portion 135 by the elastic action of the spring 735. Can do.

On the other hand, the rotating screw support portion 740 (FIG. 26) is different from the rotating screw support portion 640 of FIG. 23 in that it has a bearing 745 instead of the

thrust ball bearings

645 and 646, but the other portions are almost the same. It is constituted similarly.

The bearing 745 is made of a resin material like the

bearings

642 and 643, and the sliding friction of the rotating screw portion 737 with respect to the relay portion 737B is small.

With this configuration, the rotating screw support portion 740 is rotated so as to be able to rotate smoothly without displacing its position in any of the left-right direction, the front-rear direction, and the up-down direction, similarly to the rotating screw support portion 640 of FIG. The threaded portion 637 can be supported.

[4-3. Other Embodiment 3]
Furthermore, in the embodiment described above, the inlet 131E and the outlet 131F are each formed in a long hole shape that is long in the left-right direction, so that the outer peripheral side surface port 132BH and the inlet 131E are located at any position within the piston movement range. Or the case where the connection state with the outflow port 131F was maintained and the chemical solution was allowed to flow in or out between the flow pipe 132C and the inflow pipe 131C or the outflow pipe 131D was described.

However, the present invention is not limited to this, and by forming at least one of the outer peripheral side surface port 132BH and the inflow port 131E and the outflow port 131F in the shape of a long hole, the outer peripheral side surface port 132BH The inlet 131E or the outlet 131F may be connected. In this case, when the piston 132 is in the contact position and the separation position, even if there is a deviation between the outer peripheral side surface port 132BH and the inflow port 131E or the outflow port 131F, it suffices if it is in an overlapping position.

For example, in the delivery unit 830 shown in FIG. 27, a cylinder 831 instead of the cylinder 131 has an inflow port 831E and an outflow port 831F made of round holes. The piston 832 has a hole portion 832BH formed of a long hole instead of the outer peripheral side surface port 132BH formed of a round hole.

This delivery part 830 connects the hole part 832BH and the inflow port 831E or the outflow port 831F at any position within the piston movement range as in the above-described delivery part 130, and connects the flow pipe 132C and the inflow pipe 131C or the outflow line. A chemical solution can flow in or out from the tube 131D.

[4-4. Other Embodiment 4]
Further, in the above-described embodiment, when the claw portion 135A is configured to be short with respect to the left-right direction, that is, the moving direction of the piston 132 in FIG. 8, the

restriction plates

136B and 136C are set to be longer than the piston moving range. Said.

However, the present invention is not limited to this, and the claw portion 135A and the restricting

plates

136B and 136C only need to be in a position where the piston 132 is in the contact position and the separation position in the left-right direction.

For example, as shown in FIG. 28, the sending unit 930 includes a screw receiving unit 935 and a regulating unit 936 that replace the screw receiving unit 135 and the regulating unit 136 of the sending unit 730. In the screw receiving portion 935, the length in the left-right direction of the claw portion 935A corresponding to the claw portion 135A of the delivery portion 730 is longer than the piston movement range. On the other hand, the restricting plates 936B and 936C of the restricting portion 936 are as short as the length of the claw portion 135A in the left-right direction.

The sending portion 930 can restrict the rotation range of the piston 132 to about 180 ° by bringing the claw portion 935A into contact with the restriction plate 936B or 936C, and also when moving the piston 132 in the left-right direction. While using the claw portion 935A as a guide rail, the rotation range can be maintained by sliding the claw portion 935A on the restriction plate 936B or 936C.

[4-5. Other Embodiment 5]
Furthermore, in the above-described embodiment, as shown in FIG. 23, one claw portion 135A is provided in the screw receiving portion 135 that rotates integrally with the piston 132, and two restriction portions 136 fixed to the cylinder 131 are provided. The case where the

restriction plates

136B and 136C are provided has been described.

However, the present invention is not limited to this, and two

claw portions

1035A and 1035B are provided in the screw receiving portion 1035, and one restriction portion 1036 is provided, for example, as in the delivery portion 1030 shown in FIGS. The restriction plate 1036B may be provided.

Like the delivery unit 130, the delivery unit 1030 regulates the rotation range of the piston 132 to about 180 °, and can continue to regulate the rotation range even when the piston 132 moves over the piston movement range. it can.

[4-6. Other Embodiment 6]
Further, in the above-described embodiment, as shown in FIG. 23, the inflow pipe 131C and the inflow port 131E are provided on the front side of the cylinder 131, and the outflow pipe 131D and the outflow port 131F are provided on the rear side, and the front side of the internal space 131S and The case where the rotation range of the piston 132 is restricted to about 180 ° by the

restriction plates

136B and 136C provided on the rear side has been described.

However, the present invention is not limited to this, and the inflow pipe 131C and the inflow port 131E are provided in an arbitrary direction in the cylinder 131, and the outflow pipe 131D and the outflow port 131F are provided in different directions, and correspond to these in the internal space 131S. The restriction plates 136 B and 136 C may be provided in the direction in which the rotation of the piston 132 is restricted to an arbitrary angle.

However, in this case, the direction in which the inlet pipe 131C and the inlet 131E are provided and the direction in which the outlet pipe 131D and the outlet 131F are provided to some extent so that the outer peripheral side surface port 132BH of the piston 132 is not connected simultaneously with the inlet 131E and outlet 131F. It is desirable to pull apart.

For example, in the delivery part 1230 shown in FIGS. 30 and 31, the inflow pipe 1231C and the inflow port 1231E are provided on the upper side of the cylinder 1231, and the restriction plate 1236B of the restriction part 1236 is provided on the upper side of the internal space 131S. The rotation range may be restricted to about 90 °.

[4-7. Other Embodiment 7]
Furthermore, in the above-described embodiment, the case where the bottom surface 131A of the cylinder 131 and the end surface 132A of the piston 132 are formed in a planar shape has been described.

However, the present invention is not limited to this, and each may have an arbitrary shape. In this case, it is desirable that the bottom surface 131A and the end surface 132A have shapes corresponding to each other, so that when the piston 132 is in the contact position, the volume of the storage space 131L is substantially zero and can flow out without leaving the internal chemical.

[4-8. Other Embodiment 8]
Furthermore, in the above-described embodiment, the rotational driving force of the motor 207 is non-contacted by the rotational screw portion by magnetically coupling the power transmission magnet 209 of the drive control unit 20 and the driving magnet 138C of the delivery unit 130. The case of transmitting to 137 has been described.

However, the present invention is not limited to this. For example, the rotational driving force of the motor 207 may be transmitted to the rotating screw portion 137 by contact with a predetermined gear.

[4-9. Other Embodiment 9]
Further, in the above-described embodiment, the case where the airtightness between the piston 132 and the cylinder 131 is improved by providing the O-ring 133 on the outer peripheral side surface 132B of the piston 132 has been described.

However, the present invention is not limited to this. For example, an X ring may be provided instead of the O ring, an O ring or an X ring may be provided on the inner peripheral side surface 131B of the cylinder 131, and a piston may be provided. A piston made of silicon rubber, butadiene rubber or the like may be attached to 132.

[4-10. Other Embodiment 10]
Furthermore, in the above-described embodiment, the case where a medicine such as insulin is delivered by the delivery unit 130 has been described.

However, the present invention is not limited to this, and various objects (so-called fluids) having fluidity such as various liquids and various gases may be transmitted by the delivery unit 130.

The present invention can be applied to the medical field, for example.

DESCRIPTION OF SYMBOLS 1 ... Chemical solution administration system, 2 ... Chemical solution administration apparatus, 3 ... Controller, 4 ... Charger, 10 ... Chemical solution storage and delivery part, 20 ... Drive control part, 30 ... Puncture flow path part, 106, 107... Channel pipe, 110... Chemical solution bag, 130... Delivery part, 131... Cylinder, 131 A .. Bottom surface, 131 B. ... Inlet, 131F ... Outlet, 131L ... Storage space, 131S ... Internal space, 132 ... Piston, 132A ... End face, 132AH ... End face port, 132B ... Outer peripheral side, 132BH ... Outer peripheral side , 132C... Distribution pipe, 135... Screw receiving portion, 135A .. claw portion, 135B... Screw hole, 136... Restricting portion, 136B and 136C. Threaded part 138 ...... rotation transmitting unit, X ...... central axis

Claims

A chemical liquid administration device that is used by being attached to the body surface of a user,
A chemical storage section for storing the chemical,
A cylinder having a cylindrical inner peripheral side surface and a bottom surface of a predetermined shape;
A reservoir for supplying the drug solution;
An inflow port formed on the inner peripheral side surface of the cylinder, which communicates via an inflow path connected to the reservoir;
Provided on the inner peripheral side surface of the cylinder that communicates through a predetermined outflow path to a hollow needle that supplies the chemical solution to the user's body, and rotates by a predetermined angle from the inflow port about the central axis of the cylinder An outlet formed in the position,
An outer peripheral side surface in contact with the inner peripheral side surface of the cylinder, an end surface in contact with the chemical solution, the other end surface facing the end surface, and an outer peripheral side surface port provided on the outer peripheral side surface and a flow path connecting the end surface are provided. A piston that slides in an inner space of the cylinder formed by the inner peripheral side surface and the bottom surface of the cylinder in the direction of the central axis of the cylinder;
A piston thread portion in which a thread groove is formed on the other end surface side of the piston;
A screw that is screwed into the piston screw portion and rotated about the central axis of the cylinder by the rotation driving portion, and larger than the peripheral side frictional force generated between the cylinder and the piston when the rotation is performed. A rotating screw portion that generates a frictional force between the piston screw portion,
In the cylinder, when the piston rotates about the central axis of the cylinder, a piston orientation that is an orientation that the outer peripheral side port faces, an inflow direction that connects the outer peripheral side port to the inflow port, and the inflow direction And a rotation restricting portion that restricts the rotation within a rotation range sandwiched between an outflow direction that rotates the piston and connects the outer peripheral side surface port to the outflow port.
By energizing the rotary screw portion with respect to the piston screw portion in a direction in which the piston slides, the screw friction force larger than the peripheral side friction force is generated when the rotary screw portion is rotated. The drug solution administration device according to claim 1, further comprising a screw urging unit.
The rotating screw part and the rotation restricting part are:
Regarding the direction along the central axis of the cylinder, the sum of the lengths of the portions that engage with each other when the piston orientation becomes the inflow direction or the outflow direction is calculated as follows. The medicinal-solution administration device according to claim 1, wherein the medicinal-solution administration device is not less than a moving range of moving along the line.
The inlet and the outlet are
The medicinal-solution administration device according to claim 3, characterized in that the piston is a long hole longer than a moving range in which the piston moves along the central axis of the cylinder.
The outer peripheral side opening is
The medicinal-solution administration device according to claim 3, characterized in that the piston is a long hole longer than a moving range in which the piston moves along the central axis of the cylinder.
The rotation restricting portion is
A piston side protruding portion provided on the piston and protruding outward from the center axis of the cylinder toward the outside;
A cylinder-side engaging portion that is provided in the cylinder and engages with the piston-side protrusion when the piston orientation becomes the inflow orientation or the outflow orientation,
The piston-side protruding portion and the cylinder-side engaging portion are
When the piston azimuth becomes the inflow azimuth or the outflow azimuth and is engaged with each other, and the piston moves relative to the cylinder along the central axis of the cylinder by the rotation of the rotary screw portion, The medicinal-solution administration device according to claim 1, wherein the piston azimuth is maintained in the inflow azimuth or the outflow azimuth by holding.
At least one of the piston side protruding portion and the cylinder side engaging portion is:
The piston azimuth is the inflow azimuth or the outflow azimuth, and the piston has a constant shape with respect to the direction along the central axis of the cylinder over a moving range in which the piston moves along the central axis of the cylinder with respect to the cylinder. The drug solution administration device according to claim 6, wherein the drug solution is brought into contact with the other party.
At least one of the inlet and the outlet and the outer peripheral side surface is
The medicinal-solution administration device according to claim 1, wherein the piston is a long hole that is long in a sliding direction.