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WO2013119950A3 - Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer - Google Patents

Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer Download PDF

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Publication number
WO2013119950A3
WO2013119950A3 PCT/US2013/025345 US2013025345W WO2013119950A3 WO 2013119950 A3 WO2013119950 A3 WO 2013119950A3 US 2013025345 W US2013025345 W US 2013025345W WO 2013119950 A3 WO2013119950 A3 WO 2013119950A3
Authority
WO
WIPO (PCT)
Prior art keywords
ros1
fusions
methods
diagnosing
treating cancer
Prior art date
Application number
PCT/US2013/025345
Other languages
French (fr)
Other versions
WO2013119950A2 (en
Inventor
David HOUT
John HANDSHOE
Original Assignee
Insight Genetics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insight Genetics, Inc. filed Critical Insight Genetics, Inc.
Priority to EP13746869.0A priority Critical patent/EP2812451A4/en
Priority to JP2014556726A priority patent/JP2015508644A/en
Priority to CN201380013401.4A priority patent/CN104364391A/en
Priority to AU2013216904A priority patent/AU2013216904A1/en
Publication of WO2013119950A2 publication Critical patent/WO2013119950A2/en
Publication of WO2013119950A3 publication Critical patent/WO2013119950A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Disclosed are methods and compositions for detecting the presence of a cancer in a subject and assessing the efficacy of treatments for the same. The disclosed method use real-time polymerase chain reaction, reverse transcription polymerase chain reaction (RT-PCR), in situ hybridization and/or multiplex polymerase chain reaction techniques to detect the presence of point mutations, truncations, or fusions of ROS1.
PCT/US2013/025345 2012-02-08 2013-02-08 Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer WO2013119950A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP13746869.0A EP2812451A4 (en) 2012-02-08 2013-02-08 METHODS AND COMPOSITIONS RELATING TO ROS1 FUSIONS FOR DIAGNOSING AND TREATING CANCER
JP2014556726A JP2015508644A (en) 2012-02-08 2013-02-08 Methods and compositions relating to fusions of ROS1 for the diagnosis and treatment of cancer
CN201380013401.4A CN104364391A (en) 2012-02-08 2013-02-08 Methods and compositions relating to fusions of ROS1 for diagnosing and treating cancer
AU2013216904A AU2013216904A1 (en) 2012-02-08 2013-02-08 Methods and compositions relating to fusions of ROS1 for diagnosing and treating cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261596720P 2012-02-08 2012-02-08
US61/596,720 2012-02-08

Publications (2)

Publication Number Publication Date
WO2013119950A2 WO2013119950A2 (en) 2013-08-15
WO2013119950A3 true WO2013119950A3 (en) 2014-11-13

Family

ID=48948165

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/025345 WO2013119950A2 (en) 2012-02-08 2013-02-08 Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer

Country Status (5)

Country Link
EP (1) EP2812451A4 (en)
JP (1) JP2015508644A (en)
CN (1) CN104364391A (en)
AU (1) AU2013216904A1 (en)
WO (1) WO2013119950A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2924062C (en) 2013-09-10 2019-05-14 Board Of Regents Of The University Of Texas System Therapeutics targeting truncated adenomatous polyposis coli (apc) proteins
US10231965B2 (en) * 2014-02-20 2019-03-19 Ignyta, Inc. Molecules for administration to ROS1 mutant cancer cells
US9914973B2 (en) * 2014-03-25 2018-03-13 Quest Diagnostics Investments Incorporated Detection of gene fusions by intragenic differential expression (IDE) using average cycle thresholds
US10082496B2 (en) * 2014-09-10 2018-09-25 Board Of Regents Of The University Of Texas System Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis
HK1244485A1 (en) 2014-12-02 2018-08-10 亚尼塔公司 Combinations for the treatment of neuroblastoma
CN104830989A (en) * 2015-05-25 2015-08-12 上海允英医疗科技有限公司 Detection kit for fusion mutation of ROS1 and various genes
CN108138230B (en) * 2015-07-21 2023-03-10 夸登特健康公司 Locked nucleic acids for capturing fusion genes
AU2016370846B2 (en) 2015-12-18 2022-08-25 Ignyta, Inc. Combinations for the treatment of cancer
KR102718538B1 (en) 2017-07-19 2024-10-21 이그니타, 인코포레이티드 Pharmaceutical composition comprising entrectinib
WO2019077506A1 (en) 2017-10-17 2019-04-25 Ignyta, Inc. Pharmaceutical compositions and dosage forms
CN113473990A (en) * 2018-10-08 2021-10-01 锐新医药公司 SHP2 inhibitor composition for treating cancer
WO2024072805A1 (en) * 2022-09-26 2024-04-04 Lau, Johnson Yiu-Nam Compositions, systems, and methods for detection of ovarian cancer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060240434A1 (en) * 2003-03-07 2006-10-26 Jean Gabert Standardized and optimized real-time quantitative reverse transcriptase polymerase chain reaction method for detection of mrd in leukemia
US20100143918A1 (en) * 2007-01-19 2010-06-10 Cell Signaling Technology, Inc. Translocation and mutant ros kinase in human non-small cell lung carcinoma
WO2010132888A2 (en) * 2009-05-15 2010-11-18 Insight Genetics, Inc. Methods and compositions relating to fusions of alk for diagnosing and treating cancer
US20110287445A1 (en) * 2009-02-12 2011-11-24 Cell Signaling Technology, Inc. Mutant ROS Expression In Human Cancer
WO2011162295A1 (en) * 2010-06-22 2011-12-29 アステラス製薬株式会社 Detection method for novel ros1 fusion product

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084631A2 (en) * 2006-01-20 2007-07-26 Cell Signaling Technology, Inc. Translocation and mutant ros kinase in human non-small cell lung carcinoma
WO2011146945A2 (en) * 2010-05-21 2011-11-24 Cell Signaling Technology, Inc. Alk and ros kinase in cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060240434A1 (en) * 2003-03-07 2006-10-26 Jean Gabert Standardized and optimized real-time quantitative reverse transcriptase polymerase chain reaction method for detection of mrd in leukemia
US20100143918A1 (en) * 2007-01-19 2010-06-10 Cell Signaling Technology, Inc. Translocation and mutant ros kinase in human non-small cell lung carcinoma
US20110287445A1 (en) * 2009-02-12 2011-11-24 Cell Signaling Technology, Inc. Mutant ROS Expression In Human Cancer
WO2010132888A2 (en) * 2009-05-15 2010-11-18 Insight Genetics, Inc. Methods and compositions relating to fusions of alk for diagnosing and treating cancer
WO2011162295A1 (en) * 2010-06-22 2011-12-29 アステラス製薬株式会社 Detection method for novel ros1 fusion product

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2812451A4 *

Also Published As

Publication number Publication date
JP2015508644A (en) 2015-03-23
WO2013119950A2 (en) 2013-08-15
CN104364391A (en) 2015-02-18
EP2812451A4 (en) 2016-01-06
AU2013216904A1 (en) 2014-08-28
EP2812451A2 (en) 2014-12-17

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