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WO2013104918A3 - Binding molecule - Google Patents

Binding molecule Download PDF

Info

Publication number
WO2013104918A3
WO2013104918A3 PCT/GB2013/050054 GB2013050054W WO2013104918A3 WO 2013104918 A3 WO2013104918 A3 WO 2013104918A3 GB 2013050054 W GB2013050054 W GB 2013050054W WO 2013104918 A3 WO2013104918 A3 WO 2013104918A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding
binding molecule
antigen
domains
inpgsggt
Prior art date
Application number
PCT/GB2013/050054
Other languages
French (fr)
Other versions
WO2013104918A2 (en
Inventor
Dorian Haskard
Shang-Hung CHANG
Michael Johns
Original Assignee
Imperial Innovations Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Innovations Limited filed Critical Imperial Innovations Limited
Publication of WO2013104918A2 publication Critical patent/WO2013104918A2/en
Publication of WO2013104918A3 publication Critical patent/WO2013104918A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to an isolated specific binding member, such as an antibody or fragment thereof, which is capable of binding an antigen on oxidised low density lipoprotein (ox LDL). The antigen is capable of being bound by a member comprising one or more binding domains selected from domains comprising an amino acid sequence substantially as set out as GYAFTNYL, INPGSGGT and ARSFKWKFDY.
PCT/GB2013/050054 2012-01-13 2013-01-11 Binding molecule WO2013104918A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1200563.3 2012-01-13
GB201200563A GB201200563D0 (en) 2012-01-13 2012-01-13 Binding molecule

Publications (2)

Publication Number Publication Date
WO2013104918A2 WO2013104918A2 (en) 2013-07-18
WO2013104918A3 true WO2013104918A3 (en) 2013-08-29

Family

ID=45813980

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2013/050054 WO2013104918A2 (en) 2012-01-13 2013-01-11 Binding molecule

Country Status (2)

Country Link
GB (1) GB201200563D0 (en)
WO (1) WO2013104918A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019027903A1 (en) 2017-08-02 2019-02-07 Phanes Therapeutics, Inc. Anti-cd47 antibodies and uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002103363A2 (en) * 2001-06-18 2002-12-27 Medical Research Council Selection by avidity capture
WO2005049635A2 (en) * 2003-11-14 2005-06-02 Vollmers Philip Human monoclonal antibody having fat-reducing effect
CN1730492A (en) * 2004-08-04 2006-02-08 中山大学中山眼科中心 Single-chain antibody for lactoferrin , method for making same and uses
EP1852508A2 (en) * 2001-05-30 2007-11-07 The Kitasato Institute Actinomycetes polynucleotides
US20100311954A1 (en) * 2002-03-01 2010-12-09 Xencor, Inc. Optimized Proteins that Target Ep-CAM
WO2011006915A2 (en) * 2009-07-16 2011-01-20 Glaxo Group Limited Improved anti-serum albumin binding single variable domains
WO2011042548A1 (en) * 2009-10-09 2011-04-14 Sanofi-Aventis Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1852508A2 (en) * 2001-05-30 2007-11-07 The Kitasato Institute Actinomycetes polynucleotides
WO2002103363A2 (en) * 2001-06-18 2002-12-27 Medical Research Council Selection by avidity capture
US20100311954A1 (en) * 2002-03-01 2010-12-09 Xencor, Inc. Optimized Proteins that Target Ep-CAM
WO2005049635A2 (en) * 2003-11-14 2005-06-02 Vollmers Philip Human monoclonal antibody having fat-reducing effect
CN1730492A (en) * 2004-08-04 2006-02-08 中山大学中山眼科中心 Single-chain antibody for lactoferrin , method for making same and uses
WO2011006915A2 (en) * 2009-07-16 2011-01-20 Glaxo Group Limited Improved anti-serum albumin binding single variable domains
WO2011042548A1 (en) * 2009-10-09 2011-04-14 Sanofi-Aventis Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHANG-HUNG CHANG ET AL: "Model IgG Monoclonal Autoantibody-Anti-Idiotype Pair for Dissecting the Humoral Immune Response to Oxidized Low Density Lipoprotein", HYBRIDOMA, vol. 31, no. 2, 17 April 2012 (2012-04-17), pages 87 - 98, XP055067564, ISSN: 1554-0014, DOI: 10.1089/hyb.2011.0058 *

Also Published As

Publication number Publication date
GB201200563D0 (en) 2012-02-29
WO2013104918A2 (en) 2013-07-18

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