WO2013104201A1 - Bipolar reflective time-of-flight mass spectrometer - Google Patents
Bipolar reflective time-of-flight mass spectrometer Download PDFInfo
- Publication number
- WO2013104201A1 WO2013104201A1 PCT/CN2012/082633 CN2012082633W WO2013104201A1 WO 2013104201 A1 WO2013104201 A1 WO 2013104201A1 CN 2012082633 W CN2012082633 W CN 2012082633W WO 2013104201 A1 WO2013104201 A1 WO 2013104201A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- flight mass
- time
- region
- positive
- ion
- Prior art date
Links
Images
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
Definitions
- the invention relates to an analytical instrument detection technology, in particular to a bipolar reflective time-of-flight mass analyzer.
- Time-of-flight mass The principle of analyzer is: under vacuum environment, different ions with the same acceleration energy will have different flight speeds. After a certain length of field flight, the ions will be separated and detected according to the mass-to-charge ratio.
- This mass separation technology has high resolution, high sensitivity, no upper limit of quality detection, microsecond detection speed, and full spectrum detection in one detection cycle. It is widely used in chemical engineering, energy, medicine, materials science, environmental science. , life sciences and other fields. Based on its principle and characteristics, the unipolar time-of-flight mass analyzer can only detect ions of one polarity. If simultaneous detection of bipolar ions is required, two complete sets of time-of-flight mass analyzers are required.
- the linear bipolar time-of-flight mass analyzer due to the linear structural characteristics, the positive and negative ion analysis systems can only be aligned correctly, and the space utilization rate is not high.
- the long effective flying length of the ion causes the linear bipolar time-of-flight mass analyzer to have a simple structure, but the performance is not high, the volume is large, and the weight is heavy, which further affects the configuration of the vacuum system and the electric system, so that the vacuum and electric system design , production, maintenance is more complicated and increases the cost of the instrument.
- a bipolar reflective time-of-flight mass analyzer comprising: an ionization extraction region, a positive ion time-of-flight mass analyzer, and a negative ion time-of-flight mass analyzer, the ionization extraction region being located in a positive ion time-of-flight mass analyzer and a negative ion flight
- the ionization lead-out area and the positive ion time-of-flight mass analyzer and the negative ion time-of-flight mass analyzer are arranged in a "Z" type combination to form a reflective structure.
- the ionization extraction zone is located at the center of symmetry of the entire device, and positive ions and negative ions are simultaneously ionized from this region.
- the ionization extraction area ionization mode may be pulsed laser ionization, or other ionization methods such as an electron bombardment source.
- the positive ion time-of-flight mass analyzer is composed of a positive ion acceleration region, a positive ion focusing lens, a positive ion reflection region, a positive ion drift region and a positive ion detection region.
- the negative ion time-of-flight mass analyzer is composed of a negative ion acceleration region, a negative ion focusing lens, a negative ion reflecting region, a negative ion drift region and a negative ion detecting region.
- the positive ion focusing lens and the negative ion focusing lens are respectively disposed in the positive ion drift region and the negative ion drift region for adjusting the ion beam width.
- the positive ion reflection region and the negative ion reflection region are respectively placed at an angle of more than 0° and less than 45° with the positive ion acceleration region and the negative ion acceleration region to control the ion flight path to ensure detection efficiency; the positive ion reflection region, The negative ion reflection region is at an angle of 4.5° with the positive ion acceleration region and the negative ion acceleration region, respectively, and the deflection direction is opposite, so that the ions are deflected by about 9° in opposite directions.
- the positive ion detection zone and the negative ion detection zone are respectively disposed on reflection paths of positive and negative ions.
- the positive and negative ion acceleration zones and reflective zones may be meshed or netless.
- the positive and negative ion focusing lenses are conventional one- or two-dimensional electrostatic lenses.
- the positive and negative ion focusing lenses can be realized by applying a focusing lens electric field on the pole piece by the positive ion acceleration region and the negative ion acceleration region, respectively.
- the positive and negative ion detection zones are ion detectors composed of conventional two-piece microchannel plates.
- the positive and negative ion detection zones are placed at an angle of 5 degrees to the acceleration zone.
- the positive and negative ion time-of-flight mass analyzers apply opposite polarity voltages.
- the voltage applied to the ionization extraction region may be direct current or pulsed.
- the working principle of the invention is that the positive and negative ions generated in the ionization lead-out area fly out in opposite directions under the action of a strong electrostatic field or a pulse electric field in the lead-out area, and the ions are accelerated for ions of any polarity. After obtaining the same kinetic energy, the ions with different mass-to-charge ratios will have different flight speeds. The ions with a small mass-to-charge ratio will fly faster, and the ions with a large mass-to-charge ratio will fly at a slower speed.
- the reflection zone After being reflected by the reflection zone, it is separated according to its mass-to-charge ratio; the ion with the lowest mass-to-charge ratio first reaches the detection zone to be detected, and the ion with large mass-to-charge ratio is focused to reach the detection zone, and the time-of-flight mass spectrum is detected.
- the principle of the invention is also that the positive and negative ions generated by the instantaneous ionization can be simultaneously detected, and the complete positive and negative ion mass spectrum can be obtained in one detection period.
- the ion beam width can be controlled by an electrostatic focusing lens to ensure ion transport efficiency.
- the ion flight path is controlled by adjusting the angle of the reflection zone to optimize the overall analyzer structure while maintaining performance.
- the spatial focusing of the same mass-to-charge ratio ions during transmission is achieved by adjusting the voltages of the respective accelerating and reflecting electrodes.
- the invention has the following beneficial effects: the structure can simultaneously perform positive and negative ion detection after the ion is generated, and truly reflect the sample component information; the reflective structure adopted has a "Z"-shaped structure. Arrangement not only increases the effective flight length of the ions, improves the performance of the analyzer, and makes the structure more compact and reasonable, greatly improving space utilization. At the same time, the electrostatic focusing lens technology is used to improve the ion transmission efficiency.
- Figure 1 is a schematic view of the structure of the present invention.
- Figure 1 is a schematic view of the structure of the present invention. As can be seen from Figure 1, the device comprises an ionization extraction zone and a positive and negative ion time-of-flight mass analyzer.
- the ionization extraction zone 2 is located at the center of symmetry of the entire device, and the positive ions 6 and the negative ions 12 are simultaneously ionized.
- the positive ion time-of-flight mass analyzer is composed of a positive ion acceleration region 3, a positive ion focusing lens 4, a positive ion drift region 5, a positive ion reflection region 7, and a positive ion detecting region 1.
- the negative ion time-of-flight mass analyzer is composed of a negative ion acceleration region 9, a negative ion focusing lens 10, a negative ion drift region 11, a negative ion reflecting region 13, and a negative ion detecting region 8.
- the time-of-flight mass analyzer adopts a reflective structure and is arranged in a "Z" type combination; the positive ion focusing lens 4 and the negative ion focusing lens 10 are respectively placed in the positive ion drift region 5 and the negative ion drift region 11 for adjustment
- the ion beam width; the positive ion reflection region 7 and the negative ion reflection region 13 are at an angle of about 4.5° with the positive ion acceleration region 3 and the negative ion acceleration region 9, and the deflection directions are opposite, so that the ions are deflected by about 9° in opposite directions; positive ion detection
- the zone 1 and the negative ion detection zone 8 are respectively placed on the reflection paths of the positive and negative ions.
- the electric field of the ionization lead-out area is about 4 ⁇ 10 5 V/m
- the acceleration voltage of the positive and negative ions is about ⁇ /+4000V
- the whole device is placed in a vacuum environment better than 1 ⁇ 10 ⁇ 4 Pa.
- the positive ions 6 generated by the ionization extraction region 2 are accelerated by the positive ion acceleration region 3, pass through the positive ion focusing lens 4 and the positive ion drift region 5, and are deflected and reflected by the positive ion reflection region 7 to the positive ion detection region 1 for separation detection. .
- the negative ions 12 generated by the ionization extraction region 2 are accelerated by the negative ion acceleration region 9, pass through the negative ion focusing lens 10 and the negative ion drift region 11, and are deflected and reflected by the negative ion reflection region 13 to the negative ion detection region 8 for separation detection.
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
A bipolar time-of-flight mass spectrometer comprises an ionization lead-out area (2), a positive ion time-of-flight mass spectrometer and a negative ion time-of-flight mass spectrometer. The bipolar time-of-flight mass spectrometer is characterized in that the ionization lead-out area (2) is located between the positive ion time-of-flight mass spectrometer and the negative ion time-of-flight mass spectrometer, the ionization lead-out area (2), the positive ion time-of-flight mass spectrometer and the negative ion time-of-flight mass spectrometer are combined in a 'Z' shape and form a reflecting structure. The bipolar time-of-flight mass spectrometer has the advantages that not only effective flight length of ions is increased and performance of the spectrometer is improved, but also the structure is more compact and reasonable and the space utilization ratio is greatly improved. Besides, transmission efficiency of ions is improved by using static focusing lens technology.
Description
技术领域Technical field
本发明涉及一种分析仪器检测技术，特别涉及一种双极性反射式飞行时间质量分析器。The invention relates to an analytical instrument detection technology, in particular to a bipolar reflective time-of-flight mass analyzer.
背景技术Background technique
飞行时间质量分析器（time-of-flight mass
analyzer）原理为：真空环境下，获得相同加速能量的不同离子，将拥有不同的飞行速度，则通过一定长度无场飞行后，离子将按照其质荷比的大小得以分离检测。这种质量分离技术分辨率、灵敏度高，无质量检测上限，具有微秒级检测速度，且能在一个检测周期内完成全谱检测，被广泛应用于化工、能源、医药、材料科学、环境科学、生命科学等领域。基于其原理及特点可知，单极性的飞行时间质量分析器只能检测一种极性的离子，如果要实现双极性离子同时检测，就需要完整的两套飞行时间质量分析器。常规直线式双极性飞行时间质量分析器中，由于直线式的结构特点，正负离子分析系统只能正对排列，空间利用率不高；同时，为实现高分辨和高质量检测范围，需要较长的离子有效飞行长度，造成了直线式双极飞行时间质量分析器虽然结构简单，但性能不高，体积大，重量重，进一步影响了真空系统及电系统的配置，使真空及电系统设计、制作、维护更为复杂且增加了仪器成本。Time-of-flight mass
The principle of analyzer is: under vacuum environment, different ions with the same acceleration energy will have different flight speeds. After a certain length of field flight, the ions will be separated and detected according to the mass-to-charge ratio. This mass separation technology has high resolution, high sensitivity, no upper limit of quality detection, microsecond detection speed, and full spectrum detection in one detection cycle. It is widely used in chemical engineering, energy, medicine, materials science, environmental science. , life sciences and other fields. Based on its principle and characteristics, the unipolar time-of-flight mass analyzer can only detect ions of one polarity. If simultaneous detection of bipolar ions is required, two complete sets of time-of-flight mass analyzers are required. In the conventional linear bipolar time-of-flight mass analyzer, due to the linear structural characteristics, the positive and negative ion analysis systems can only be aligned correctly, and the space utilization rate is not high. At the same time, in order to achieve high resolution and high quality detection range, it is necessary to compare The long effective flying length of the ion causes the linear bipolar time-of-flight mass analyzer to have a simple structure, but the performance is not high, the volume is large, and the weight is heavy, which further affects the configuration of the vacuum system and the electric system, so that the vacuum and electric system design , production, maintenance is more complicated and increases the cost of the instrument.
发明内容Summary of the invention
本发明的目的是提供一种双极性反射式飞行时间质量分析器，提高了分析器的空间利用率，缩小了分析器的体积。It is an object of the present invention to provide a bipolar reflective time-of-flight mass analyzer that increases the space utilization of the analyzer and reduces the size of the analyzer.
为实现上述目的，本发明所采用的技术方案是：In order to achieve the above object, the technical solution adopted by the present invention is:
一种双极性反射式飞行时间质量分析器，包括：电离引出区、正离子飞行时间质量分析器、负离子飞行时间质量分析器，所述电离引出区位于正离子飞行时间质量分析器与负离子飞行时间质量分析器的之间，电离引出区及正离子飞行时间质量分析器、负离子飞行时间质量分析器呈“Z”型组合排列，形成反射式结构。A bipolar reflective time-of-flight mass analyzer comprising: an ionization extraction region, a positive ion time-of-flight mass analyzer, and a negative ion time-of-flight mass analyzer, the ionization extraction region being located in a positive ion time-of-flight mass analyzer and a negative ion flight Between the time quality analyzers, the ionization lead-out area and the positive ion time-of-flight mass analyzer and the negative ion time-of-flight mass analyzer are arranged in a "Z" type combination to form a reflective structure.
所述电离引出区位于整个装置对称中心，正离子及负离子由此区域同时电离产生。电离引出区电离方式可以是脉冲式激光电离，也可以是其它电离方式如电子轰击源等。The ionization extraction zone is located at the center of symmetry of the entire device, and positive ions and negative ions are simultaneously ionized from this region. The ionization extraction area ionization mode may be pulsed laser ionization, or other ionization methods such as an electron bombardment source.
所述正离子飞行时间质量分析器由正离子加速区、正离子聚焦透镜、正离子反射区、正离子漂移区及正离子检测区相连接组成。The positive ion time-of-flight mass analyzer is composed of a positive ion acceleration region, a positive ion focusing lens, a positive ion reflection region, a positive ion drift region and a positive ion detection region.
所述负离子飞行时间质量分析器由负离子加速区、负离子聚焦透镜、负离子反射区、负离子漂移区及负离子检测区相连接组成。The negative ion time-of-flight mass analyzer is composed of a negative ion acceleration region, a negative ion focusing lens, a negative ion reflecting region, a negative ion drift region and a negative ion detecting region.
所述正离子聚焦透镜、负离子聚焦透镜分别置于正离子漂移区、负离子漂移区内，用于调节离子束宽度。The positive ion focusing lens and the negative ion focusing lens are respectively disposed in the positive ion drift region and the negative ion drift region for adjusting the ion beam width.
所述正离子反射区、负离子反射区分别与正离子加速区、负离子加速区成大于0°且小于45°的夹角放置，以控制离子飞行路径，保证检测效率；所述正离子反射区、负离子反射区分别与正离子加速区、负离子加速区成4.5°夹角，偏转方向相反，使离子成相反方向偏转约9°反射。The positive ion reflection region and the negative ion reflection region are respectively placed at an angle of more than 0° and less than 45° with the positive ion acceleration region and the negative ion acceleration region to control the ion flight path to ensure detection efficiency; the positive ion reflection region, The negative ion reflection region is at an angle of 4.5° with the positive ion acceleration region and the negative ion acceleration region, respectively, and the deflection direction is opposite, so that the ions are deflected by about 9° in opposite directions.
所述正离子检测区和负离子检测区分别置于正、负离子的反射路径上。The positive ion detection zone and the negative ion detection zone are respectively disposed on reflection paths of positive and negative ions.
所述正、负离子加速区及反射区可以是有网的或无网的。The positive and negative ion acceleration zones and reflective zones may be meshed or netless.
所述正、负离子聚焦透镜是常规的一维或二维静电透镜。The positive and negative ion focusing lenses are conventional one- or two-dimensional electrostatic lenses.
所述正、负离子聚焦透镜可分别由正离子加速区和负离子加速区通过在极片上施加聚焦透镜电场来实现。The positive and negative ion focusing lenses can be realized by applying a focusing lens electric field on the pole piece by the positive ion acceleration region and the negative ion acceleration region, respectively.
所述正、负离子检测区为常规的双片微通道板组成的离子检测器。The positive and negative ion detection zones are ion detectors composed of conventional two-piece microchannel plates.
所示正、负离子检测区与加速区成5度夹角放置。The positive and negative ion detection zones are placed at an angle of 5 degrees to the acceleration zone.
所述正、负离子飞行时间质量分析器施加相反极性电压。The positive and negative ion time-of-flight mass analyzers apply opposite polarity voltages.
所述电离引出区施加电压可以直流的，也可以是脉冲式的。The voltage applied to the ionization extraction region may be direct current or pulsed.
本发明的工作原理是：电离引出区产生的正负离子，在引出区强静电场或脉冲电场的作用下，分别朝相反的方向飞出，针对其中任一极性的离子而言，离子经加速区后获得相同的动能，则不同质荷比的离子将拥有不同的飞行速度，质荷比小的离子飞行速度快，质荷比大的离子飞行速度慢，通过一定距离的无场飞行，再经反射区反射后，按其质荷比大小进行分离；最终质荷比小的离子先聚焦到达检测区得以检测，质荷比大的离子后聚焦到达检测区，得以检测形成飞行时间质量谱。The working principle of the invention is that the positive and negative ions generated in the ionization lead-out area fly out in opposite directions under the action of a strong electrostatic field or a pulse electric field in the lead-out area, and the ions are accelerated for ions of any polarity. After obtaining the same kinetic energy, the ions with different mass-to-charge ratios will have different flight speeds. The ions with a small mass-to-charge ratio will fly faster, and the ions with a large mass-to-charge ratio will fly at a slower speed. After being reflected by the reflection zone, it is separated according to its mass-to-charge ratio; the ion with the lowest mass-to-charge ratio first reaches the detection zone to be detected, and the ion with large mass-to-charge ratio is focused to reach the detection zone, and the time-of-flight mass spectrum is detected.
本发明的原理还在于：瞬时电离生成的正负离子得以同时检测，一个检测周期内即可得到完整正负离子质量谱。通过静电聚焦透镜可以控制离子束宽度，来保证离子的传输效率。通过调节反射区放置角度来控制离子飞行路径，在保证性能的前提下优化整个分析器结构。通过调节各加速及反射电极电压来实现传输过程中相同质荷比离子的空间聚焦。The principle of the invention is also that the positive and negative ions generated by the instantaneous ionization can be simultaneously detected, and the complete positive and negative ion mass spectrum can be obtained in one detection period. The ion beam width can be controlled by an electrostatic focusing lens to ensure ion transport efficiency. The ion flight path is controlled by adjusting the angle of the reflection zone to optimize the overall analyzer structure while maintaining performance. The spatial focusing of the same mass-to-charge ratio ions during transmission is achieved by adjusting the voltages of the respective accelerating and reflecting electrodes.
与现有技术相比，本发明具有如下的有益效果：本结构在离子产生后，可同时进行正负离子检测，真实反映样品成分信息；所采用的反射式结构，并呈“Z”字型结构排列，不仅增加离子的有效飞行长度，提高了分析器性能，并且使结构更加紧凑合理，大幅提高空间利用率。同时，采用静电聚焦透镜技术提高离子的传输效率。Compared with the prior art, the invention has the following beneficial effects: the structure can simultaneously perform positive and negative ion detection after the ion is generated, and truly reflect the sample component information; the reflective structure adopted has a "Z"-shaped structure. Arrangement not only increases the effective flight length of the ions, improves the performance of the analyzer, and makes the structure more compact and reasonable, greatly improving space utilization. At the same time, the electrostatic focusing lens technology is used to improve the ion transmission efficiency.
附图说明DRAWINGS
图1 为本发明的结构示意图。Figure 1 is a schematic view of the structure of the present invention.
具体实施方式detailed description
下面结合实施例及附图对本发明作进一步详细的描述，但本发明的实施方式不限于此。The present invention will be further described in detail below with reference to the embodiments and drawings, but the embodiments of the present invention are not limited thereto.
图1为本发明的结构示意图。由图1可见，本装置包括电离引出区和正、负离子飞行时间质量分析器三部分。Figure 1 is a schematic view of the structure of the present invention. As can be seen from Figure 1, the device comprises an ionization extraction zone and a positive and negative ion time-of-flight mass analyzer.
所述的电离引出区2位于整个装置对称中心，正离子6，负离子12由此区域同时电离产生。The ionization extraction zone 2 is located at the center of symmetry of the entire device, and the positive ions 6 and the negative ions 12 are simultaneously ionized.
所述的正离子飞行时间质量分析器由正离子加速区3、正离子聚焦透镜4、正离子漂移区5、正离子反射区7、正离子检测区1组成。The positive ion time-of-flight mass analyzer is composed of a positive ion acceleration region 3, a positive ion focusing lens 4, a positive ion drift region 5, a positive ion reflection region 7, and a positive ion detecting region 1.
所述的负离子飞行时间质量分析器由负离子加速区9、负离子聚焦透镜10、负离子漂移区11、负离子反射区13、负离子检测区8组成。The negative ion time-of-flight mass analyzer is composed of a negative ion acceleration region 9, a negative ion focusing lens 10, a negative ion drift region 11, a negative ion reflecting region 13, and a negative ion detecting region 8.
所述的飞行时间质量分析器采用反射式结构，并呈“Z”型组合排列；正离子聚焦透镜4和负离子聚焦透镜10分别置于正离子漂移区5和负离子漂移区11内，用于调节离子束宽度；正离子反射区7和负离子反射区13与正离子加速区3和负离子加速区9成约4.5°夹角，偏转方向相反，使离子成相反方向偏转约9°反射；正离子检测区1和负离子检测区8分别置于正、负离子的反射路径上。The time-of-flight mass analyzer adopts a reflective structure and is arranged in a "Z" type combination; the positive ion focusing lens 4 and the negative ion focusing lens 10 are respectively placed in the positive ion drift region 5 and the negative ion drift region 11 for adjustment The ion beam width; the positive ion reflection region 7 and the negative ion reflection region 13 are at an angle of about 4.5° with the positive ion acceleration region 3 and the negative ion acceleration region 9, and the deflection directions are opposite, so that the ions are deflected by about 9° in opposite directions; positive ion detection The zone 1 and the negative ion detection zone 8 are respectively placed on the reflection paths of the positive and negative ions.
所述的电离引出区电场约为4×105V/m，正、负离子加速电压约为-/+4000V，整个装置置于真空环境优于1×10-4Pa。The electric field of the ionization lead-out area is about 4×10 5 V/m, the acceleration voltage of the positive and negative ions is about −/+4000V, and the whole device is placed in a vacuum environment better than 1×10 −4 Pa.
电离引出区2生成的正离子6经正离子加速区3加速后，穿过正离子聚焦透镜4及正离子漂移区5，再由正离子反射区7偏转反射至正离子检测区1得以分离检测。The positive ions 6 generated by the ionization extraction region 2 are accelerated by the positive ion acceleration region 3, pass through the positive ion focusing lens 4 and the positive ion drift region 5, and are deflected and reflected by the positive ion reflection region 7 to the positive ion detection region 1 for separation detection. .
电离引出区2生成的负离子12经负离子加速区9加速后，穿过负离子聚焦透镜10及负离子漂移区11，再由负离子反射区13偏转反射至负离子检测区8得以分离检测。The negative ions 12 generated by the ionization extraction region 2 are accelerated by the negative ion acceleration region 9, pass through the negative ion focusing lens 10 and the negative ion drift region 11, and are deflected and reflected by the negative ion reflection region 13 to the negative ion detection region 8 for separation detection.
上述实施例为本发明较佳的实施方式，但本发明的实施方式并不受上述实施例的限制，其他的任何未背离本发明的精神实质与原理下所作的改变、修饰、替代、组合、简化，均应为等效的置换方式，都包含在本发明的保护范围之内。
The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and combinations thereof may be made without departing from the spirit and scope of the invention. Simplifications should all be equivalent replacements and are included in the scope of the present invention.
Claims (10)
- 一种双极性反射式飞行时间质量分析器，包括电离引出区、正离子飞行时间质量分析器、负离子飞行时间质量分析器，其特征在于：所述电离引出区位于正离子飞行时间质量分析器与负离子飞行时间质量分析器的之间；电离引出区及正离子飞行时间质量分析器、负离子飞行时间质量分析器呈“Z”型组合排列，形成反射式结构。 A bipolar reflective time-of-flight mass analyzer comprising an ionization extraction region, a positive ion time-of-flight mass analyzer, and a negative ion time-of-flight mass analyzer, wherein the ionization extraction region is located in a positive ion time-of-flight mass analyzer Between the negative ion time-of-flight mass analyzer; the ionization lead-out area and the positive ion time-of-flight mass analyzer and the negative ion time-of-flight mass analyzer are arranged in a "Z" type combination to form a reflective structure.
- 根据权利要求1所述的双极性反射式飞行时间质量分析器，其特征在于：所述电离引出区位于整个装置对称中心。The bipolar reflective time-of-flight mass analyzer of claim 1 wherein said ionization extraction region is located at a center of symmetry of the entire device.
- 根据权利要求1所述的双极性反射式飞行时间质量分析器，其特征在于：所述正离子飞行时间质量分析器由正离子加速区、正离子聚焦透镜、正离子反射区、正离子漂移区及正离子检测区相连接组成；所述负离子飞行时间质量分析器由负离子加速区、负离子聚焦透镜、负离子反射区、负离子漂移区及负离子检测区相连接组成。The bipolar reflective time-of-flight mass analyzer according to claim 1, wherein the positive ion time-of-flight mass analyzer comprises a positive ion acceleration region, a positive ion focusing lens, a positive ion reflection region, and a positive ion drift. The region and the positive ion detection region are connected to each other; the negative ion time-of-flight mass analyzer is composed of a negative ion acceleration region, a negative ion focusing lens, a negative ion reflection region, a negative ion drift region and a negative ion detection region.
- 据权利要求1所述的双极性反射式飞行时间质量分析器，其特征在于：所述正离子聚焦透镜、负离子聚焦透镜分别置于正离子漂移区、负离子漂移区内。The bipolar reflective time-of-flight mass analyzer according to claim 1, wherein the positive ion focusing lens and the negative ion focusing lens are respectively disposed in a positive ion drift region and a negative ion drift region.
- 根据权利要求1所述的双极性反射式飞行时间质量分析器，其特征在于：所述正离子反射区、负离子反射区分别与正离子加速区、负离子加速区成大于0°且小于45°的夹角放置。The bipolar reflective time-of-flight mass analyzer according to claim 1, wherein the positive ion reflection region and the negative ion reflection region are respectively greater than 0° and less than 45° with the positive ion acceleration region and the negative ion acceleration region. Place the angle.
- 根据权利要求5所述的双极性反射式飞行时间质量分析器，其特征在于：所述正离子反射区、负离子反射区分别与正离子加速区、负离子加速区成4.5°夹角，偏转方向相反，使离子成相反方向偏转约9°反射。The bipolar reflective time-of-flight mass analyzer according to claim 5, wherein the positive ion reflection region and the negative ion reflection region are respectively at an angle of 4.5° with the positive ion acceleration region and the negative ion acceleration region, and the deflection direction is Instead, the ions are deflected by about 9° in opposite directions.
- 据权利要求1所述的双极性反射式飞行时间质量分析器，其特征在于：所述正离子检测区和负离子检测区分别置于正、负离子的反射路径上。The bipolar reflective time-of-flight mass analyzer of claim 1 wherein said positive ion detection zone and negative ion detection zone are respectively disposed on reflection paths of positive and negative ions.
- 根据权利要求1所述的双极性反射式飞行时间质量分析器，其特征在于：所述正、负离子加速区及反射区是有网的或无网的。The bipolar reflective time-of-flight mass analyzer of claim 1 wherein said positive and negative ion acceleration zones and said reflective zones are meshed or netless.
- 根据权利要求1所述的双极性反射式飞行时间质量分析器，其特征在于：所述正、负离子聚焦透镜是一维或二维静电透镜，或为双片微通道板组成的离子检测器。The bipolar reflective time-of-flight mass analyzer according to claim 1, wherein the positive and negative ion focusing lenses are one-dimensional or two-dimensional electrostatic lenses, or ion detectors composed of two-piece microchannel plates. .
- 据权利要求1所述的双极性反射式飞行时间质量分析器，其特征在于：所述正、负离子聚焦透镜分别由正离子加速区和负离子加速区通过在极片上施加聚焦透镜电场来实现。The bipolar reflective time-of-flight mass analyzer of claim 1 wherein said positive and negative ion focusing lenses are respectively implemented by a positive ion acceleration zone and a negative ion acceleration zone by applying a focusing lens electric field to the pole piece.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210007412.9 | 2012-01-11 | ||
| CN2012100074129A CN102568997A (en) | 2011-02-15 | 2012-01-11 | Bipolar reflection-type flight time mass analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2013104201A1 true WO2013104201A1 (en) | 2013-07-18 |
Family
ID=48782757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2012/082633 WO2013104201A1 (en) | 2012-01-11 | 2012-10-09 | Bipolar reflective time-of-flight mass spectrometer |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2013104201A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040024539A1 (en) * | 2001-10-25 | 2004-02-05 | The Regents Of The University Of California | Real-time detection method and system for identifying individual aerosol particles |
| CN101789355A (en) * | 2010-03-18 | 2010-07-28 | 广州禾信分析仪器有限公司 | Time-of-flight mass spectrometer with wide dynamic range, implementation method and application thereof |
| CN102568997A (en) * | 2011-02-15 | 2012-07-11 | 上海大学 | Bipolar reflection-type flight time mass analyzer |
-
2012
- 2012-10-09 WO PCT/CN2012/082633 patent/WO2013104201A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040024539A1 (en) * | 2001-10-25 | 2004-02-05 | The Regents Of The University Of California | Real-time detection method and system for identifying individual aerosol particles |
| CN101789355A (en) * | 2010-03-18 | 2010-07-28 | 广州禾信分析仪器有限公司 | Time-of-flight mass spectrometer with wide dynamic range, implementation method and application thereof |
| CN102568997A (en) * | 2011-02-15 | 2012-07-11 | 上海大学 | Bipolar reflection-type flight time mass analyzer |
| CN202502980U (en) * | 2011-02-15 | 2012-10-24 | 上海大学 | Bipolar reflection-type time-of-flight mass analyzer |
Non-Patent Citations (2)
| Title |
|---|
| HE, JIAN ET AL.: "Development of Laser Ablation and Ionization Orthogonal Time-of-Flight Mass Spectrometer", JOURNAL OF CHINESE MASS SPECTROMETRY SOCIETY, vol. 31, no. 5, September 2010 (2010-09-01), pages 264 - 268 * |
| HUANG, ZHENGXU ET AL.: "Development of a Real-Time Single Particle Aerosol Time-of-Flight Mass Spectrometer", JOURNAL OF CHINESE MASS SPECTROMETRY SOCIETY, vol. 31, no. 6, November 2010 (2010-11-01), pages 331 - 336 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9543138B2 (en) | Ion optical system for MALDI-TOF mass spectrometer | |
| US8513597B2 (en) | Atom probe | |
| US20130327935A1 (en) | Method and device for increasing the throughput in time-of-flight mass spectrometers | |
| EP1460674A2 (en) | Mass spectrometer and methods of mass spectrometry | |
| US8957392B2 (en) | Mass spectrometer | |
| WO2010116396A1 (en) | Ion trap device | |
| JPS6229049A (en) | Mass spectrometer | |
| CA2343582C (en) | Mass spectrometer and methods of mass spectrometry | |
| CN105529240B (en) | Utilize the time of-flight mass spectrometer of wide mass range space-focusing | |
| CN202502980U (en) | Bipolar reflection-type time-of-flight mass analyzer | |
| JP5885474B2 (en) | Mass distribution analysis method and mass distribution analyzer | |
| JPH11297267A (en) | Time-of-fiight mass spectrometer | |
| JP2011175897A (en) | Mass spectrometer | |
| JP2014215173A (en) | Maldi ion trap mass spectrometry apparatus | |
| WO2013104201A1 (en) | Bipolar reflective time-of-flight mass spectrometer | |
| JPH0450699B2 (en) | ||
| JP6160472B2 (en) | Time-of-flight mass spectrometer | |
| JP6750684B2 (en) | Ion analyzer | |
| WO2015019460A1 (en) | Time-of-flight mass-spectrometer | |
| JP6624790B2 (en) | Projection type charged particle optical system and imaging mass spectrometer | |
| JP2015179629A (en) | Time-of-flight type mass spectroscope | |
| US3217161A (en) | Electrode means to electrostatically focus ions separated by a mass spectrometer on a detector | |
| JP2018010766A (en) | Time-of-flight mass spectrometer | |
| JP2768450B2 (en) | Mass spectrometer | |
| JP2014225339A (en) | Time-of-flight mass spectrometer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 12865260 Country of ref document: EP Kind code of ref document: A1 |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 12865260 Country of ref document: EP Kind code of ref document: A1 |