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WO2013167986A3 - Compositions and methods for the treatment of epilepsy - Google Patents

Compositions and methods for the treatment of epilepsy Download PDF

Info

Publication number
WO2013167986A3
WO2013167986A3 PCT/IB2013/050740 IB2013050740W WO2013167986A3 WO 2013167986 A3 WO2013167986 A3 WO 2013167986A3 IB 2013050740 W IB2013050740 W IB 2013050740W WO 2013167986 A3 WO2013167986 A3 WO 2013167986A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorder
formula
seizures
syndrome
compositions
Prior art date
Application number
PCT/IB2013/050740
Other languages
French (fr)
Other versions
WO2013167986A2 (en
Inventor
Mahesh Kandula
Original Assignee
Cellixbio Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellixbio Private Limited filed Critical Cellixbio Private Limited
Priority to AU2013257707A priority Critical patent/AU2013257707A1/en
Priority to JP2015510893A priority patent/JP2015526385A/en
Priority to SG11201407309XA priority patent/SG11201407309XA/en
Priority to EP13787779.1A priority patent/EP2846795A2/en
Priority to CA2873016A priority patent/CA2873016A1/en
Publication of WO2013167986A2 publication Critical patent/WO2013167986A2/en
Priority to PCT/IB2013/060667 priority patent/WO2014087367A2/en
Priority to ZA2014/08058A priority patent/ZA201408058B/en
Publication of WO2013167986A3 publication Critical patent/WO2013167986A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to the compounds of formula (I) and formula (II) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I) or formula (II); and methods for treating or preventing neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of epilepsy, bipolar disorder, trigeminal neuralgia, attention-deficit hyperactivity disorder, partial seizures, adjunctive therapy for partial, myoclonic, tonic-clonic seizures and schizophrenia, neuropathic pain, seizures, Tourette syndrome, Alzheimer's disease, autism, bipolar disorder and anxiety disorder, bipolar disorder, mania, phantom limb syndrome, complex regional pain syndrome, paroxysmal extreme pain disorder, neuromyotoaia, intermittent explosive disorder, borderline personality disorder, myotonia congenita and post-traumatic stress disorder.
PCT/IB2013/050740 2012-05-08 2013-01-29 Compositions and methods for the treatment of epilepsy WO2013167986A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2013257707A AU2013257707A1 (en) 2012-05-08 2013-01-29 Compositions and methods for the treatment of epilepsy
JP2015510893A JP2015526385A (en) 2012-05-08 2013-01-29 Compositions and methods for the treatment of epilepsy
SG11201407309XA SG11201407309XA (en) 2012-05-08 2013-01-29 Compositions and methods for the treatment of epilepsy
EP13787779.1A EP2846795A2 (en) 2012-05-08 2013-01-29 Compositions and methods for the treatment of epilepsy
CA2873016A CA2873016A1 (en) 2012-05-08 2013-01-29 Compositions and methods for the treatment of epilepsy
PCT/IB2013/060667 WO2014087367A2 (en) 2012-12-09 2013-12-05 Compositions and methods for the treatment of neurological diseases and its associated complications
ZA2014/08058A ZA201408058B (en) 2012-05-08 2014-11-04 Compositions and methods for the treatment of epilepsy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1791/CHE/2012 2012-05-08
IN1791CH2012 2012-05-08

Publications (2)

Publication Number Publication Date
WO2013167986A2 WO2013167986A2 (en) 2013-11-14
WO2013167986A3 true WO2013167986A3 (en) 2015-06-18

Family

ID=54187089

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/050740 WO2013167986A2 (en) 2012-05-08 2013-01-29 Compositions and methods for the treatment of epilepsy

Country Status (7)

Country Link
EP (1) EP2846795A2 (en)
JP (1) JP2015526385A (en)
AU (1) AU2013257707A1 (en)
CA (1) CA2873016A1 (en)
SG (1) SG11201407309XA (en)
WO (1) WO2013167986A2 (en)
ZA (1) ZA201408058B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2873094A1 (en) * 2012-05-07 2013-11-14 Cellixbio Private Limited Prodrugs of anti-platelet agents
SG11201407328TA (en) * 2012-07-03 2014-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of moderate to severe pain
BR112016028231A2 (en) 2014-06-02 2017-08-22 Ketogen Inc compounds and their uses and pharmaceutical compositions

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034606A1 (en) * 1995-05-05 1996-11-07 Novo Nordisk A/S Pharmaceutical composition containing tiagabine hydrochloride and the process for its preparation
WO2006062980A2 (en) * 2004-12-07 2006-06-15 Nektar Therapeutics Stable non-crystalline formulation comprising tiagabine
EP1806339A1 (en) * 2005-12-21 2007-07-11 Ucb, S.A. Process for the preparation of 2-oxo-1-pyrrolidine derivatives
WO2010132693A2 (en) * 2009-05-13 2010-11-18 Nektar Therapeutics Oligomer-containing pyrrolidine compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034606A1 (en) * 1995-05-05 1996-11-07 Novo Nordisk A/S Pharmaceutical composition containing tiagabine hydrochloride and the process for its preparation
WO2006062980A2 (en) * 2004-12-07 2006-06-15 Nektar Therapeutics Stable non-crystalline formulation comprising tiagabine
EP1806339A1 (en) * 2005-12-21 2007-07-11 Ucb, S.A. Process for the preparation of 2-oxo-1-pyrrolidine derivatives
WO2010132693A2 (en) * 2009-05-13 2010-11-18 Nektar Therapeutics Oligomer-containing pyrrolidine compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AS ABOVE *

Also Published As

Publication number Publication date
AU2013257707A1 (en) 2014-11-27
EP2846795A2 (en) 2015-03-18
WO2013167986A2 (en) 2013-11-14
JP2015526385A (en) 2015-09-10
SG11201407309XA (en) 2014-12-30
CA2873016A1 (en) 2013-11-14
ZA201408058B (en) 2016-03-30

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