[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

WO2012173442A3 - 봉독 포스포리파아제를 유효성분으로 포함하는 프리온 질병 치료용 조성물 - Google Patents

봉독 포스포리파아제를 유효성분으로 포함하는 프리온 질병 치료용 조성물 Download PDF

Info

Publication number
WO2012173442A3
WO2012173442A3 PCT/KR2012/004782 KR2012004782W WO2012173442A3 WO 2012173442 A3 WO2012173442 A3 WO 2012173442A3 KR 2012004782 W KR2012004782 W KR 2012004782W WO 2012173442 A3 WO2012173442 A3 WO 2012173442A3
Authority
WO
WIPO (PCT)
Prior art keywords
active ingredient
bee venom
composition
composition containing
phospholipase
Prior art date
Application number
PCT/KR2012/004782
Other languages
English (en)
French (fr)
Other versions
WO2012173442A9 (ko
WO2012173442A2 (ko
Inventor
박상열
정재교
문명희
설재원
이유진
Original Assignee
전북대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 전북대학교산학협력단 filed Critical 전북대학교산학협력단
Publication of WO2012173442A2 publication Critical patent/WO2012173442A2/ko
Publication of WO2012173442A9 publication Critical patent/WO2012173442A9/ko
Publication of WO2012173442A3 publication Critical patent/WO2012173442A3/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01004—Phospholipase A2 (3.1.1.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Insects & Arthropods (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 봉독으로부터 분리된 봉독 포스포리파아제 A2(phospholipase A2, Group Ⅲ sPLA2)를 유효성분으로 포함하는 조성물에 관한 것으로서, AKT 또는 p-38 MAPK 키나제의 발현을 조절하여 변형 프리온 단백질에 의해서 유발되는 신경세포 사멸을 억제하여 퇴행성 뇌질환의 치료가 가능한 것을 특징으로 하며, 본 발명에 따른 Group sPLA를 유효성분으로 포함하는 조성물은 신경 퇴행 인자의 활성을 조절할 수 있고, 이에 의해서 변형 프리온 단백질에 의해서 유발되는 신경세포의 사멸을 유효하게 억제할 수 있으며, 퇴행성 뇌질환의 예방 및 치료용 약학 조성물로 유용하게 이용될 수 있다.
PCT/KR2012/004782 2011-06-17 2012-06-18 봉독 포스포리파아제를 유효성분으로 포함하는 프리온 질병 치료용 조성물 WO2012173442A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0059048 2011-06-17
KR1020110059048A KR101272888B1 (ko) 2011-06-17 2011-06-17 봉독 포스포리파아제를 유효성분으로 포함하는 프리온 질병 치료용 조성물

Publications (3)

Publication Number Publication Date
WO2012173442A2 WO2012173442A2 (ko) 2012-12-20
WO2012173442A9 WO2012173442A9 (ko) 2013-03-28
WO2012173442A3 true WO2012173442A3 (ko) 2013-05-16

Family

ID=47357286

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/KR2011/010341 WO2012173319A1 (ko) 2011-06-17 2011-12-29 봉독 포스포리파아제를 유효성분으로 포함하는 프리온 질병 치료용 조성물
PCT/KR2012/004782 WO2012173442A2 (ko) 2011-06-17 2012-06-18 봉독 포스포리파아제를 유효성분으로 포함하는 프리온 질병 치료용 조성물

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/010341 WO2012173319A1 (ko) 2011-06-17 2011-12-29 봉독 포스포리파아제를 유효성분으로 포함하는 프리온 질병 치료용 조성물

Country Status (2)

Country Link
KR (1) KR101272888B1 (ko)
WO (2) WO2012173319A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101896938B1 (ko) 2017-03-16 2018-09-12 대한민국 크로마토그래피를 이용한 봉독 내 포스포리파아제 a2의 분리 방법
CN113924105A (zh) * 2019-03-28 2022-01-11 英斯特盛泰株式会社 包含蜂毒提取物作为活性成分的用于预防或治疗神经炎症紊乱的组合物
US20220211821A1 (en) 2019-05-08 2022-07-07 University-Inoustry Cooperation Group Of Kyung Hee University Composition for preventing or treating obesity, comprising phospholipase a2 as active ingredient
WO2022139457A1 (ko) * 2020-12-24 2022-06-30 이니스트에스티 주식회사 봉독 추출물로부터 bvPLA2를 50~99% 함량으로 포함하는 봉독 주사제 조성물 및 이의 제조방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780416B1 (en) * 2000-02-18 2004-08-24 Ecole Polytechnique Federale De Lausanne Bee venom polypeptides and methods of use thereof
KR20100125991A (ko) * 2009-05-22 2010-12-01 주식회사 휴온스 봉독으로부터 분리된 봉독 정제물을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 및 치료를 위한 조성물

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780416B1 (en) * 2000-02-18 2004-08-24 Ecole Polytechnique Federale De Lausanne Bee venom polypeptides and methods of use thereof
KR20100125991A (ko) * 2009-05-22 2010-12-01 주식회사 휴온스 봉독으로부터 분리된 봉독 정제물을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 및 치료를 위한 조성물

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOON,D.O., INT. IMMUNOPHARMACOL., vol. 409, no. 2, 27 July 2006 (2006-07-27), pages 1796 - 1807 *

Also Published As

Publication number Publication date
WO2012173442A9 (ko) 2013-03-28
KR101272888B1 (ko) 2013-06-11
WO2012173442A2 (ko) 2012-12-20
WO2012173319A1 (ko) 2012-12-20
KR20120139313A (ko) 2012-12-27

Similar Documents

Publication Publication Date Title
JOP20120246B1 (ar) مركبات و تركيبات كمثبطات كيناز c-Kit
TN2013000348A1 (en) Compounds and compositions as trk inhibitors
MX2014002486A (es) Compuestos y composiciones como inhibidores de cinasa pdgfr.
GT201400034A (es) Compuestos y composiciones como inhibidores de la quinasa c-kit
PH12018501065A1 (en) Compounds and compositions useful for treating disorders related to ntrk
WO2014019908A3 (en) Substituted pyrroles active as kinases inhibitors
WO2012170931A3 (en) Compounds that modulate intracellular calcium
WO2014031928A3 (en) Heterocyclic modulators of hif activity for treatment of disease
WO2012177603A3 (en) Metalloenzyme inhibitor compounds
WO2014100620A3 (en) Compounds and methods for kinase modulation, and indications therefor
WO2014039714A3 (en) Compounds and methods for kinase modulation, and indications therefor
MX358128B (es) Compuestos y métodos para la modulación de quinasas e indicaciones para los mismos.
IN2014DN00286A (ko)
WO2013153479A3 (en) Indole and indazole compounds that activate ampk
WO2011014795A3 (en) Compounds and compositions as syk kinase inhibitors
UY33597A (es) Compuestos y composiciones como inhibidores de la trk
WO2014081878A3 (en) Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival
EA201490539A1 (ru) Соединения и композиции в качестве ингибиторов c-kit киназы
WO2012027710A3 (en) Compounds that modulate intracellular calcium
WO2014031933A3 (en) Heterocyclic modulators of hif activity for treatment of disease
WO2012065102A3 (en) S-t-butyl protected cysteine di-peptide analogs and related compounds
WO2012170951A3 (en) Compounds that modulate intracellular calcium
WO2014037315A3 (en) Active compound combinations
WO2011139765A3 (en) Compounds that modulate intracellular calcium
WO2014079545A8 (en) Thioether derivatives as protein kinase inhibitors

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12800178

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12800178

Country of ref document: EP

Kind code of ref document: A2