[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

WO2012056451A3 - Peripheral blood gene markers for early diagnosis of parkinson's disease - Google Patents

Peripheral blood gene markers for early diagnosis of parkinson's disease Download PDF

Info

Publication number
WO2012056451A3
WO2012056451A3 PCT/IL2011/000830 IL2011000830W WO2012056451A3 WO 2012056451 A3 WO2012056451 A3 WO 2012056451A3 IL 2011000830 W IL2011000830 W IL 2011000830W WO 2012056451 A3 WO2012056451 A3 WO 2012056451A3
Authority
WO
WIPO (PCT)
Prior art keywords
parkinson
disease
peripheral blood
early diagnosis
gene markers
Prior art date
Application number
PCT/IL2011/000830
Other languages
French (fr)
Other versions
WO2012056451A2 (en
WO2012056451A9 (en
Inventor
Silvia A Mandel
Moussa B.H. Youdim
Peter Riederer
Edna Grunblatt
Jose M. Rabey
Leonid Molochnikov
Original Assignee
Silvia A Mandel
Youdim Moussa B H
Peter Riederer
Edna Grunblatt
Rabey Jose M
Leonid Molochnikov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Silvia A Mandel, Youdim Moussa B H, Peter Riederer, Edna Grunblatt, Rabey Jose M, Leonid Molochnikov filed Critical Silvia A Mandel
Priority to MX2013004747A priority Critical patent/MX2013004747A/en
Priority to AU2011322108A priority patent/AU2011322108A1/en
Priority to BR112013010069A priority patent/BR112013010069A2/en
Priority to EP11793500.7A priority patent/EP2633078B1/en
Priority to CA2815896A priority patent/CA2815896A1/en
Priority to US13/881,963 priority patent/US20130217028A1/en
Publication of WO2012056451A2 publication Critical patent/WO2012056451A2/en
Publication of WO2012056451A3 publication Critical patent/WO2012056451A3/en
Priority to IL225977A priority patent/IL225977A/en
Publication of WO2012056451A9 publication Critical patent/WO2012056451A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to the use of molecular risk marker profiles for diagnosis of Parkinson's disease. More particularly, the invention provides methods for diagnosis of Parkinson's disease in an individual, utilizing certain profiles established based on the expression levels of certain genes, which together form a gene panel, in the peripheral blood of said individual, as well as kits for carrying out these methods. The profile encompass ALDH1A1.
PCT/IL2011/000830 2010-10-26 2011-10-26 Peripheral blood gene markers for early diagnosis of parkinson's disease WO2012056451A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
MX2013004747A MX2013004747A (en) 2010-10-26 2011-10-26 Peripheral blood gene markers for early diagnosis of parkinson's disease.
AU2011322108A AU2011322108A1 (en) 2010-10-26 2011-10-26 Peripheral blood gene markers for early diagnosis of Parkinson's disease
BR112013010069A BR112013010069A2 (en) 2010-10-26 2011-10-26 method, computerized method and parkinson's disease (pd) diagnosis kit in a tested individual
EP11793500.7A EP2633078B1 (en) 2010-10-26 2011-10-26 Peripheral blood gene markers for early diagnosis of parkinson's disease
CA2815896A CA2815896A1 (en) 2010-10-26 2011-10-26 Peripheral blood gene markers for early diagnosis of parkinson's disease
US13/881,963 US20130217028A1 (en) 2010-10-26 2011-10-26 Peripheral blood gene markers for early diagnosis of parkinson's disease
IL225977A IL225977A (en) 2010-10-26 2013-04-25 Peripheral blood gene markers for early diagnosis of parkinson's disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40678210P 2010-10-26 2010-10-26
US61/406,782 2010-10-26

Publications (3)

Publication Number Publication Date
WO2012056451A2 WO2012056451A2 (en) 2012-05-03
WO2012056451A3 true WO2012056451A3 (en) 2012-07-05
WO2012056451A9 WO2012056451A9 (en) 2013-06-13

Family

ID=45217594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2011/000830 WO2012056451A2 (en) 2010-10-26 2011-10-26 Peripheral blood gene markers for early diagnosis of parkinson's disease

Country Status (7)

Country Link
US (1) US20130217028A1 (en)
EP (1) EP2633078B1 (en)
AU (1) AU2011322108A1 (en)
BR (1) BR112013010069A2 (en)
CA (1) CA2815896A1 (en)
MX (1) MX2013004747A (en)
WO (1) WO2012056451A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7779039B2 (en) 2004-04-02 2010-08-17 Salesforce.Com, Inc. Custom entities and fields in a multi-tenant database system
CN101258483B (en) 2005-09-09 2015-08-12 易享信息技术（上海）有限公司 System and method for exporting, publishing, browsing and installing on-demand applications in a multi-tenant database environment
CN104984363B (en) * 2015-07-31 2017-12-26 固安博健生物技术有限公司 Applications of the ZMYM1 in Parkinson's diagnosis and treatment reagent is prepared
WO2018202740A1 (en) 2017-05-04 2018-11-08 Universitat De Barcelona Method for predicting early onset and severity of levodopa induced dyskinesia (lid) in subjects diagnosed of parkinson disease (pd)
WO2019092715A1 (en) * 2017-11-08 2019-05-16 Bio Shai Ltd. Methods for prognosis or treatment of parkinson's disease
WO2019217807A2 (en) * 2018-05-10 2019-11-14 Integrated Nano-Technologies, Inc. Systems and methods for determining risk or diagnosis of a neurodegenerative disease
US20220081715A1 (en) 2019-01-17 2022-03-17 Katholieke Universiteit Leuven mRNA-BASED BIOMARKERS FOR ANTIBODY-MEDIATED TRANSPLANT REJECTION

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005067391A2 (en) * 2004-01-19 2005-07-28 Technion Research & Development Foundation Ltd. Diagnostic test for parkinson's disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005067391A2 (en) * 2004-01-19 2005-07-28 Technion Research & Development Foundation Ltd. Diagnostic test for parkinson's disease

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
C ANTHONY ALTAR ET AL: "Target Identification for CNS Diseases by Transcriptional Profiling", NEUROPSYCHOPHARMACOLOGY, vol. 34, no. 1, 1 January 2009 (2009-01-01), pages 18 - 54, XP055019712, ISSN: 0893-133X, DOI: 10.1038/npp.2008.172 *
CLEMENS R. SCHERZER ET AL: "Molecular markers of early Parkinson's disease based on gene expression in blood", PNAS, vol. 104, no. 3, 16 January 2007 (2007-01-16), pages 955 - 960, XP055019562, DOI: 10.1073/pnas.0610204104 *
EDNA GRÃ 1/4 NBLATT ET AL: "Pilot study: peripheral biomarkers for diagnosing sporadic Parkinsonâ s disease", JOURNAL OF NEURAL TRANSMISSION ; BASIC NEUROSCIENCES, GENETICS AND IMMUNOLOGY, PARKINSON'S DISEASE AND ALLIED CONDITIONS, ALZHEIMER'S DISEASE AND ADOLESCENT PSYCHIATRY RELATED DISORDERS, BIOLOGICAL PSYCHIATRY, BIOLOGICAL CHILD AND ADOLESCENT PSYCHIAT, vol. 117, no. 12, 11 November 2010 (2010-11-11), pages 1387 - 1393, XP019868178, ISSN: 1435-1463, DOI: 10.1007/S00702-010-0509-1 *
GALTER DAGMAR ET AL: "ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia", NEUROBIOLOGY OF DISEASE, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB, vol. 14, no. 3, 1 December 2003 (2003-12-01), pages 637 - 647, XP002511804, ISSN: 0969-9961, DOI: 10.1016/J.NBD.2003.09.001 *
GRUNBLATT E. ET AL., PARKINSONISM AND RELATED DISORDERS, vol. 13, no. suppl. no. 2, 1.011, 10 December 2007 (2007-12-10), pages S30, XP002669982 *

Also Published As

Publication number Publication date
EP2633078B1 (en) 2018-06-13
BR112013010069A2 (en) 2016-08-02
WO2012056451A2 (en) 2012-05-03
MX2013004747A (en) 2013-11-20
US20130217028A1 (en) 2013-08-22
EP2633078A2 (en) 2013-09-04
WO2012056451A9 (en) 2013-06-13
CA2815896A1 (en) 2012-05-03
AU2011322108A1 (en) 2013-05-30

Similar Documents

Publication Publication Date Title
WO2012056451A3 (en) Peripheral blood gene markers for early diagnosis of parkinson's disease
WO2012174256A3 (en) Dna methylation profiles in cancer
WO2011095623A3 (en) miRNA IN THE DIAGNOSIS OF OVARIAN CANCER
WO2012075040A3 (en) mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
WO2009111643A3 (en) Microrna markers for recurrence of colorectal cancer
WO2011008696A3 (en) Diagnostic methods and compositions for treatment of cancer
WO2012068383A3 (en) ncRNA AND USES THEREOF
WO2013173637A8 (en) Compositions and methods for modulating gene expression
WO2009073478A3 (en) Tle3 as a marker for chemotherapy
WO2009070805A3 (en) Mir-124 regulated genes and pathways as targets for therapeutic intervention
WO2010062960A3 (en) METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
BR112014018916A2 (en) glyphosate resistance gene class
WO2008036765A3 (en) Micrornas differentially expressed in pancreatic diseases and uses thereof
AR061136A1 (en) PROCESS
WO2008154333A3 (en) Mir-34 regulated genes and pathways as targets for therapeutic intervention
WO2009108856A3 (en) Microrna signatures associated with human chronic lymphocytic leukemia (ccl) and uses thereof
EP3296406A3 (en) Mirna fingerprint in the diagnosis of lung cancer
WO2008073919A3 (en) Mir-20 regulated genes and pathways as targets for therapeutic intervention
WO2013127782A3 (en) Use of micro-rnas or genes as markers for the identification, diagnosis and therapy of individual forms of non-ischemic cardiomyopathies or storage diseases of the heart
CA2835730C (en) Molecular markers in prostate cancer
WO2008117314A3 (en) Genetic variants on chr2 and chr16 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment
WO2012083969A3 (en) Microrna for diagnosis of pancreatic cancer
WO2011122857A3 (en) Composition for predicting prognosis of breast cancer, and kit containing same
WO2012143481A3 (en) Prostate cancer markers
WO2011044458A8 (en) Compositions and methods for diagnosing genome related diseases and disorders

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11793500

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2815896

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 225977

Country of ref document: IL

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 13881963

Country of ref document: US

Ref document number: 2011793500

Country of ref document: EP

Ref document number: MX/A/2013/004747

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2011322108

Country of ref document: AU

Date of ref document: 20111026

Kind code of ref document: A

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112013010069

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 112013010069

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20130425