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WO2012047762A3 - Antifungal agents - Google Patents

Antifungal agents Download PDF

Info

Publication number
WO2012047762A3
WO2012047762A3 PCT/US2011/054371 US2011054371W WO2012047762A3 WO 2012047762 A3 WO2012047762 A3 WO 2012047762A3 US 2011054371 W US2011054371 W US 2011054371W WO 2012047762 A3 WO2012047762 A3 WO 2012047762A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
antifungal agents
useful
compositions
antifungals
Prior art date
Application number
PCT/US2011/054371
Other languages
French (fr)
Other versions
WO2012047762A2 (en
Inventor
Flórián TÓTH
Ronald Alan AUNGST Jr.
Atchyuta Rama Chandra Murty Bulusu
Robert Webb
Mitchell Mutz
Original Assignee
Amplyx Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amplyx Pharmaceuticals, Inc. filed Critical Amplyx Pharmaceuticals, Inc.
Publication of WO2012047762A2 publication Critical patent/WO2012047762A2/en
Publication of WO2012047762A3 publication Critical patent/WO2012047762A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A61K47/552—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being an antibiotic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pest Control & Pesticides (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compounds and compositions useful as antifungals are provided, as are methods of use and preparation of such compounds and compositions containing such compounds. In some embodiments, the compounds are bifunctional, comprising two active moieties connected by a linking moiety. The compounds of the invention are useful for treating infections by microorganisms.
PCT/US2011/054371 2010-10-08 2011-09-30 Antifungal agents WO2012047762A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39155510P 2010-10-08 2010-10-08
US61/391,555 2010-10-08

Publications (2)

Publication Number Publication Date
WO2012047762A2 WO2012047762A2 (en) 2012-04-12
WO2012047762A3 true WO2012047762A3 (en) 2012-07-05

Family

ID=45928343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/054371 WO2012047762A2 (en) 2010-10-08 2011-09-30 Antifungal agents

Country Status (1)

Country Link
WO (1) WO2012047762A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102659930B (en) 2012-03-30 2014-04-23 上海天伟生物制药有限公司 High-purity cyclopeptide crystal and its preparation method and use
EP2746264A1 (en) 2012-12-19 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
EP2746279A1 (en) 2012-12-19 2014-06-25 Basf Se Fungicidal imidazolyl and triazolyl compounds
EP2746255A1 (en) 2012-12-19 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
WO2014095381A1 (en) 2012-12-19 2014-06-26 Basf Se Fungicidal imidazolyl and triazolyl compounds
WO2014095249A1 (en) 2012-12-19 2014-06-26 Basf Se Fungicidal imidazolyl and triazolyl compounds
EP2746277A1 (en) 2012-12-19 2014-06-25 Basf Se Fungicidal imidazolyl and triazolyl compounds
EP2746256A1 (en) 2012-12-19 2014-06-25 Basf Se Fungicidal imidazolyl and triazolyl compounds
EP2746258A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
EP2746259A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
EP2746257A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
EP2746260A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
CA2901930C (en) 2013-03-01 2022-05-10 Fdc Limited 1-substituted, 4-(substituted phenoxymethyl)-1,2,3-triazole compounds with antifungal properties and methods for preparation thereof
EA201592157A1 (en) 2013-06-07 2016-05-31 Дзе Калифорния Инститъют Фор Биомедикал Рисёрч LOW MOLECULAR FIBROSIS INHIBITORS
CN103387548B (en) * 2013-08-08 2015-05-20 中国人民解放军第四○四医院 1,2,3-triazole antifungal compounds, and preparation method and application thereof
CN103450162B (en) * 2013-08-08 2015-07-15 中国人民解放军第一○二医院 Triazole alcohol compound containing benzamide structure and preparation method and application of triazole alcohol compound
WO2015106283A1 (en) 2014-01-13 2015-07-16 Amplyx Pharmaceuticals, Inc. Antifungal compounds
JP6706023B2 (en) 2014-12-10 2020-06-03 ザ・スクリップス・リサーチ・インスティテュート Small molecule inhibitors of fibrosis
CN104817508B (en) * 2015-03-10 2017-12-05 中国人民解放军第二军医大学 A kind of trinitrogenazole alcohol analog derivative and its preparation method and application
EP3538531A1 (en) 2016-11-10 2019-09-18 Novartis AG Bmp potentiators
WO2021077242A1 (en) * 2019-10-20 2021-04-29 鲁南贝特制药有限公司 Caspofungin synthesis method and intermediate thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040235798A1 (en) * 2001-07-05 2004-11-25 Murthi Krishna K Compositions and methods for inhibiting prenyltransferases
US20050209146A1 (en) * 1998-05-22 2005-09-22 Roger Briesewitz Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy
WO2008082198A1 (en) * 2006-12-29 2008-07-10 Daewoong Pharmaceutical Co., Ltd. Antifungal triazole derivatives, method for the preparation thereof and pharmaceutical composition containing same
WO2009055042A1 (en) * 2007-10-24 2009-04-30 Amplyx Pharmaceuticals, Inc. Enhancing the efficacy of anti-infective therapeutics
WO2010065110A2 (en) * 2008-12-01 2010-06-10 Amplyx Pharmaceuticals, Inc. Antimicrobials

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050209146A1 (en) * 1998-05-22 2005-09-22 Roger Briesewitz Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy
US20040235798A1 (en) * 2001-07-05 2004-11-25 Murthi Krishna K Compositions and methods for inhibiting prenyltransferases
WO2008082198A1 (en) * 2006-12-29 2008-07-10 Daewoong Pharmaceutical Co., Ltd. Antifungal triazole derivatives, method for the preparation thereof and pharmaceutical composition containing same
WO2009055042A1 (en) * 2007-10-24 2009-04-30 Amplyx Pharmaceuticals, Inc. Enhancing the efficacy of anti-infective therapeutics
WO2010065110A2 (en) * 2008-12-01 2010-06-10 Amplyx Pharmaceuticals, Inc. Antimicrobials

Also Published As

Publication number Publication date
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