WO2011114515A1 - Manufacturing method for soft capsule using non-animal origin outer-skin, and soft capsule - Google Patents

Abstract

Disclosed is a novel manufacturing method, which is a manufacturing procedure wherein a capsule is formed by combining starch, λ-carrageenan, metallic salt, a plasticiser, and water as the structural component composition for the raw materials for the outer-skin part of the capsule, and which has enhanced the drying ability of conventional rotary-die type soft capsule manufacturing methods, enabling the water content of a capsule outer-skin sheet to be freely adjusted, and which also has improved the previously problematic post-formation hardness-stability of the capsule. In the disclosed soft capsule manufacturing method a capsule is formed by combining starch, λ-carrageenan, metallic salt, a plasticiser, and water as the structural component composition for the raw materials for the outer-skin part of the capsule. In addition to being a novel method wherein trisodium citrate is mixed as the metallic salt, the method is characterised by the introduction to conventional rotary-die type automatic soft capsule manufacturing methods of a drying procedure for the capsule outer-skin sheet using medium wavelength infra-red radiation, thus enhancing drying ability and enabling the water content of the capsule outer-skin sheet to be freely adjusted.

Description

Method for producing soft capsule having non-animal derived skin and soft capsule

The present invention relates to "pharmaceuticals", "specialized health foods", "so-called health foods" and a method for producing soft capsules widely used in foods, particularly without using gelatin which is an animal raw material, The present invention mainly relates to a method for producing a soft capsule having a skin portion using starch, which is a vegetable raw material, and the soft capsule. *

Traditionally, soft capsules are mainly made of gelatin made from bones and skins of cows, pigs, etc., and are manufactured using a rotary die type automatic soft capsule manufacturing machine. Widely used.
However, in recent years, since the occurrence of BSE (Bovine Spondiform Encepralopany) has been reported, attention has been focused on the development of soft capsule shells using non-animal derived materials without using animal gelatin. .

Under such circumstances, Patent Documents 1 and 2 disclose a technique for encapsulating a combination of carrageenan gum and mannan gum, which are gelling agents, without using gelatin. Further, Patent Document 3 discloses a technique regarding a capsule using κ carrageenan. Furthermore, Patent Document 4 discloses a technique for capsules using ι carrageenan and κ carrageenan.

Regarding the properties of κ carrageenan and ι carrageenan, Non-Patent Document 1 states that “When κ-mono or ι-carrageenan is dispersed in water and heated to about 60 ° C. or higher, the carrageenan molecule dissolves in a random coil shape. As the material is cooled, a double helix is formed, which becomes a junction zone and gelation begins. " Because of such physical properties, when forming an encapsulated film using ι carrageenan and κ carrageenan, the encapsulated film sheet is at least 20-30 ° C. higher than when gelatin is used as the encapsulated film. Must be heated at. For this reason, the heat load on the capsule contents is large and there is a problem in quality, and the heat energy efficiency is also poor.

Under these circumstances, if the encapsulated film can be formed using λ carrageenan that does not gel unlike κ carrageenan and ι carrageenan (see Non-Patent Documents 2 and 3), the encapsulated film sheet is heated. The present inventor is advantageous in that the capsule contents can be encapsulated without applying a heat load at the same level as the conventional gelatin sheet (segment temperature: usually 35 to 50 ° C.), and the thermal energy efficiency is improved. Noticed. The inventors of the present invention have made independent efforts and succeeded in developing a soft capsule having a non-animal derived skin (capsule skin) using starch, λ carrageenan, metal salt, dextrin, plasticizer and water. First, the patent application (Patent Document 7) has been reached.

However, in a method for producing a soft capsule having a non-animal-derived capsule shell using starch, λ carrageenan, a metal salt, a plasticizer, and water with a conventional rotary die type automatic soft capsule production machine (for example, Patent Documents 5 to 6). Since the drying ability in the non-animal-derived capsule skin sheet manufacturing process is insufficient, the moisture load of the capsule skin solution must be reduced to reduce the drying load.
However, if the water content is reduced in this way, the air dissolved in the capsule shell solution becomes difficult to escape in the defoaming process, and a bubble-poor capsule is formed in which bubbles that can be visually confirmed remain on the capsule shell sheet. I had a problem.
Even if a conventional rotary die type automatic soft capsule manufacturing machine is used to reduce the drying load by reducing the amount of water blended, it is necessary to supply the high-viscosity capsule shell solution over time. When the filling speed of the capsule shell is increased, not only the drying ability in the capsule shell sheet manufacturing process cannot be followed, but also the supply of the capsule shell solution is not in time, which hinders improvement in productivity. Furthermore, a decrease in hardness over time after capsule formation has been a major problem in quality.

US Pat. No. 5,342,626 JP-A-6-329833 U.S. Pat. No. 6,214,376 Special table 2003-504326 JP 5-88143 JP2003-40768 JP2008-237572

The present invention has been made in recognition of such a background. That is, the object of the present invention is to add a certain amount of a metal salt such as trisodium citrate in the production of a soft capsule having a non-animal-derived capsule shell using starch, λ carrageenan, a metal salt, a plasticizer, and water. In addition to the new manufacturing method, the conventional rotary die type automatic soft capsule manufacturing method adopts the capsule skin sheet drying method by irradiating medium wavelength infrared rays, and the moisture content of the capsule skin sheet can be adjusted freely by enhancing the drying capacity. By developing a new capsule manufacturing method,
In order to improve the defoaming property and fluidity of the capsule shell solution, even if the amount of water is increased (90 to 200 parts by weight with respect to 100 parts by weight of starch) and the capsule shell solution is charged with a low viscosity, Capable of drying the adhesive surface uniformly and uniformly to an appropriate water content, preventing capsule foam failure, increasing capsule filling speed, and improving productivity and cost. It is to provide a new production method in which hardness stability is improved by preventing a decrease in hardness over time after formation, and a soft capsule thereof.

First, the soft capsule manufacturing method according to claim 1 supplies the outer sheet in a face-to-face relationship between a pair of die rolls, and joins the outer sheet by the butt action of the die rolls. In the method of manufacturing the soft capsule containing the contents inside the outer skin part consisting of the outer skin sheet,
The outer skin part is formed by blending starch, λ carrageenan, metal salt, plasticizer, and water as a constituent component composition of raw materials,
The amount of λ carrageenan in the outer skin part is 5 to 25 parts by weight with respect to 100 parts by weight of starch in the solution stage before drying,
The amount of the metal salt in the outer skin part is 1 to 20 parts by weight with respect to 100 parts by weight of starch in the solution stage before drying,
The skin sheet is dried by medium-wavelength infrared rays until it is joined by a pair of die rolls, thereby forming a sheet having a substantially constant thickness, moderate viscosity, and moisture content. It consists of

In addition to the requirement of claim 1, the soft capsule manufacturing method of claim 2 is characterized in that the metal salt is trisodium citrate, and the wavelength of the medium wavelength infrared ray irradiated for drying the skin sheet is 0. .8 to 4.0 μm.

In addition to the requirements of claim 1 or 2, the soft capsule manufacturing method of claim 3 has a moisture content in a stage where the outer sheet is fed between a pair of die rolls by drying by infrared irradiation of medium wavelength, Preferably, it is dried to 30 to 40%, more preferably 32 to 38%.

Further, the method for producing a soft capsule according to claim 4 is characterized in that, in addition to the requirement according to claim 1, 2, or 3, the hardness decrease with time is suppressed.

According to a fifth aspect of the present invention, in addition to the requirements of the first, second, third, or fourth aspect, the ratio to the λ carrageenan is λ carrageenan: κ carrageenan: ι carrageenan = 1: 0.1: 0. It further comprises 1 to 1: 4: 4 κ carrageenan and ι carrageenan.

Moreover, in addition to the requirements of the said claim 1, 2, 3, 4 or 5, the manufacturing method of the soft capsule of Claim 6 WHEREIN: In addition to a trisodium citrate, a sodium succinate, sodium gluconate, phosphoric acid. It is characterized by being one or a combination of two or more selected from the group consisting of disodium hydrogen, sodium dihydrogen phosphate, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, and calcium lactate.

In addition to the requirements of the first, second, third, fourth, fifth, or sixth aspect, the soft capsule manufacturing method according to the seventh aspect supplies a skin sheet oppositely between the pair of die rolls, In the method of manufacturing the soft capsule containing the contents inside the outer skin portion formed by supplying the contents to the outer skin sheet according to the joining, and supplying the contents to the outer skin sheet in accordance with the joining. When the outer sheets are joined by the butting action, the temperature of the segment part for applying heat to the outer sheets is 30 to 40 ° C.

The soft capsule according to claim 8 is manufactured by the soft capsule manufacturing method according to claim 1, 2, 3, 4, 5, 6 or 7.

When the present inventors added a certain amount of a metal salt such as trisodium citrate to λ carrageenan that does not gel before, moderate viscosity and elastic force are obtained for λ carrageenan, and soft capsule formation is achieved. The inventors found that a suitable composition can be obtained, and completed a non-animal-derived capsule shell using an unprecedented vegetable material and a soft capsule having the capsule shell.
In addition, a new soft capsule manufacturing device that can adjust the moisture content of the capsule shell sheet freely by increasing the drying capacity by combining the rotary die type automatic soft capsule manufacturing machine with the capsule shell sheet drying device using medium wavelength infrared irradiation. Development has led to the soft capsule manufacturing method of the present invention.
According to the soft capsule production method of the present invention, in the production of a soft capsule having a non-animal derived capsule shell using starch, λ carrageenan, metal salt, plasticizer and water,
In addition to a new manufacturing method of adding a certain amount of metal salt such as trisodium citrate, the conventional rotary die type automatic soft capsule manufacturing method adopts a capsule skin sheet drying method by mid-wavelength infrared irradiation to increase the drying capacity. By developing a new capsule manufacturing method that can be adjusted to freely adjust the moisture content of the capsule skin sheet,
In order to improve the defoaming property and fluidity of the capsule shell solution, even if the amount of water is increased (90 to 200 parts by weight with respect to 100 parts by weight of starch) and the capsule shell solution is charged with a low viscosity, Capable of drying the adhesive surface uniformly and uniformly to an appropriate water content, preventing capsule foam failure, increasing capsule filling speed, and improving productivity and cost. It is possible to improve hardness stability by preventing a decrease in hardness over time after formation.

The outer skin part of the non-animal derived soft capsule produced by the soft capsule production method of the present invention is formed by blending a metal salt such as starch, λ carrageenan, trisodium citrate, a plasticizer and water as a component composition. Yes, the amount of water is preferably 90 to 200 parts by weight, more preferably 110 to 180 parts per 100 parts by weight of starch in the skin solution stage before drying (in the solution stage before drying the skin part). Part by weight, particularly preferably 120 to 170 parts by weight. If it is 90 parts by weight or less, the air dissolved in the capsule shell solution is difficult to escape, and in the defoaming process, the defoaming of the air becomes insufficient. It becomes easier to form. Further, the fluidity of the capsule shell solution is deteriorated, which hinders the increase in capsule filling speed, which is not preferable. On the other hand, if it is 200 parts by weight or more, the capsule skin sheet becomes too soft and is difficult to peel off from the casting drum.

The viscosity of 90 to 200 parts by weight of water based on 100 parts by weight of starch (λ carrageenan, metal salt, and plasticizer are not added) is 75% after dissolving at a concentration of 10% and a temperature of 85 to 95 ° C. for 6 hours. It is 1500-13000 (low viscosity) measured at ° C.
On the other hand, a viscosity of 60 to 90 parts by weight of water based on 100 parts by weight of starch (with no addition of λ carrageenan, metal salt or plasticizer) was dissolved at a concentration of 10% at 85 to 95 ° C. for 6 hours. It is 13000-35000 (high viscosity) measured at 75 ° C. The viscosity was measured using a B-type viscometer manufactured by Tokimec Co., Ltd.

The metal salt used in the present invention is preferably trisodium citrate. In addition to trisodium citrate, sodium succinate, sodium gluconate, disodium hydrogen phosphate, sodium dihydrogen phosphate, potassium chloride, magnesium chloride One type selected from the group consisting of or a combination of two or more types. Among them, trisodium citrate, or a combination of trisodium citrate and sodium dihydrogen phosphate, or a combination of trisodium citrate and potassium chloride, or trisodium citrate, sodium dihydrogen phosphate and potassium chloride. Combinations are preferably used.
The mixing ratio of trisodium citrate is 1 to 20 parts by weight, preferably 2 to 15 parts by weight with respect to 100 parts by weight of starch in the skin solution stage before drying (in the solution stage before drying the skin part). Particularly preferred is 5 to 10 parts by weight. When trisodium citrate is 1 part by weight or less, it is impossible to prevent a decrease in capsule hardness over time after forming soft capsules. On the other hand, when the sodium salt is 20 parts by weight or more, the sodium salt concentration increases, which is not preferable as a soft capsule skin for health food.
When trisodium citrate and other metal salts are used in combination, the blending ratio of other metal salts is 100 parts by weight of starch at the outer skin solution stage before drying (at the solution stage before drying the outer skin part). On the other hand, 1 to 5 parts by weight of sodium dihydrogen phosphate and 0.01 to 0.3 parts by weight of potassium chloride are preferably used. More preferably, sodium dihydrogen phosphate is 1.5 to 3 parts by weight and potassium chloride is 0.03 to 0.15 parts by weight. It is not preferable that sodium dihydrogen phosphate is 5 parts by weight or more because λ carrageenan may be hydrolyzed.

[Effects of trisodium citrate addition and mid-wavelength infrared irradiation]
The present inventors give moderate viscosity and elasticity to λ carrageenan by adding a certain amount of trisodium citrate to λ carrageenan that does not gel, and combines trisodium citrate addition with medium wavelength infrared irradiation Thus, the present inventors have found that the hardness stability is improved by preventing a decrease in hardness over time after capsule formation.
In the present invention, even if only trisodium citrate is used as the metal salt, the defoaming property of the capsule shell solution is achieved by a new capsule manufacturing method that allows the moisture content of the capsule shell sheet to be freely adjusted by irradiation with medium wavelength infrared rays. In order to improve fluidity, even if the water content is increased (90 to 200 parts by weight with respect to 100 parts by weight of starch) and the capsule skin solution is charged with a low viscosity, the adhesive surface of the capsule skin sheet is evenly uniform. It can be dried to an appropriate water content, and it can improve the productivity and cost, such as prevention of capsule foam failure, increase the capsule filling speed, and the time-lapse hardness after capsule formation, which has been a problem in the prior art. Decrease can be prevented and hardness stability can be improved.

On the other hand, in the present invention, the use of trisodium citrate as a metal salt in combination with sodium dihydrogen phosphate and potassium chloride does not inhibit the action and effect of trisodium citrate. Metal salts other than sodium can be used. Although the effect is not necessarily clear, an example is shown when sodium dihydrogen phosphate and potassium chloride are added.
(1) Functions of weakly acidic metal salts such as sodium dihydrogen phosphate Since λ carrageenan is an anionic polymer, it has the property of being solubilized and transparent in the presence of cations (H ⁺ , Na ⁺ ). ing. A weakly acidic metal salt such as sodium dihydrogen phosphate is added to λ carrageenan, which is an anionic polymer, so that an appropriate viscosity (adhesiveness) can be obtained without hydrolysis.
(2) Functions of metal salts such as potassium chloride and potassium citrate By supplying K ⁺ (potassium ion) with potassium chloride to λ carrageenan, which is an anionic polymer under weak acidity, mainly K ⁺ As described above, λ carrageenan, which is an anionic polymer, forms a complex to enhance the elastic force.
(3) Function of starch (i) Mold (to be described later) in order that the gelatinized starch has a sealing property due to starch paste action in a molten state where the sheet has an appropriate viscosity (adhesiveness) and elasticity. Soft capsules are formed by pressure bonding with (die roll) and (ii) welding with starch paste.
Note that the non-animal derived soft capsules produced by combining the addition of a metal salt such as trisodium citrate according to the present invention and medium wavelength infrared irradiation are not limited to this example, and include κ carrageenan and ι carrageenan. However, the effect of adding trisodium citrate to λ carrageenan is not inhibited.

Regarding the properties of κ carrageenan and ι carrageenan, Non-Patent Document 1 described above states that “When κ- or ι-carrageenan is dispersed in water and heated to about 60 ° C. or higher, the carrageenan molecules dissolve in a random coil shape. When this solution is cooled, a double helix is formed, which becomes a junction zone and gelation begins. " Because of these physical properties, when forming an encapsulated film using ι carrageenan and κ carrageenan, encapsulation is performed more than when gelatin is used as the encapsulated film (segment temperature: usually 35 to 50 ° C.). The coated sheet must be heated at a temperature that is at least 20-30 ° C. higher. For this reason, there is a problem that the heat load on the capsule contents is large and there is a problem in quality, and the thermal energy efficiency is poor.
However, the present inventors have found that λ carrageenan has an appropriate viscosity and elasticity by adding a certain amount of metal salt to λ carrageenan that does not gel, and completed a non-animal derived soft capsule. Therefore, unlike κ carrageenan and ι carrageenan, when forming an encapsulated film with λ carrageenan, the same level as when gelatin is used (segment temperature: usually 35 to 50 ° C.) (segment temperature: 30 to 40). At a segment temperature of (° C.), the capsule contents can be encapsulated without applying an excessive heat load, and the heat energy efficiency is good.
The blending ratio of λ carrageenan is 5 to 25 parts by weight, more preferably 7 to 20 parts by weight, and particularly preferably 10 to 15 parts by weight with respect to 100 parts by weight of starch at the stage of the skin solution before drying.

The starch that is the outer skin component of the non-animal derived soft capsule of the present invention is one type or a combination of two or more types selected from the group consisting of raw starch, HP-modified starch, acid-treated starch and pregelatinized starch.
Here, the HP-modified starch which is a starch derivative is a hydroxypropyl etherified starch, and any HP-modified starch sold on the market can be used. For example, trade name TR-3 manufactured by Tokai Starch Co., Ltd., trade name Matsutani Yuri, Finex AG600 manufactured by Matsutani Chemical Industry Co., Ltd., trade name Delica KH manufactured by Nissho Chemical Co., Ltd. can be applied. Similarly, the pregelatinized starch, which is a starch derivative, is a cold water soluble starch that is gelatinized (dissolved) at room temperature. For example, trade name Tapioca Alpha-TP-2 manufactured by Sanwa Starch Co., Ltd. can be applied.

As a constituent component of the outer skin of the non-animal-derived soft capsule of the present invention, a starch decomposition product can be further used together with starch. Here, the starch degradation product is one or a combination of two or more selected from the group consisting of dextrin, maltodextrin, reduced dextrin, cyclodextrin, oligosaccharide, and polydextrose, and is a starch degradation product sold in the market. Any of them can be used. For example, trade names Paindex # 1 (dextrin), Paindex # 2 (maltodextrin), and H-PDX (reduced dextrin) manufactured by Matsutani Chemical Co., Ltd. can be used.
The blending ratio of the starch degradation product is 1 to 80 parts by weight, more preferably 5 to 50 parts by weight, and particularly preferably 10 to 30 parts by weight with respect to 100 parts by weight of starch in the outer skin solution stage before drying. .

The plasticizer that can be used in the present invention is glycerin, sugar alcohol, propylene glycol, polyethylene glycol, disaccharide, oligosaccharide, isomaltoligosaccharide and the like. The blending ratio of the plasticizer is 20 to 250 parts by weight, more preferably 30 to 80 parts by weight, and particularly preferably 35 to 70 parts by weight with respect to 100 parts by weight of starch at the stage of the skin solution before drying.

According to the method for producing a soft capsule of the present invention, in the production of a soft capsule having a non-animal-derived capsule shell using starch, λ carrageenan, a metal salt, a plasticizer and water, a certain amount or more of trisodium citrate is added as a metal salt. In addition to the new manufacturing method, the conventional rotary die type automatic soft capsule manufacturing method adopts the capsule skin sheet drying method by mid-wavelength infrared irradiation to enhance the drying capacity and freely adjust the moisture content of the capsule skin sheet By developing a new capsule manufacturing method that made possible,
In order to improve the defoaming property and fluidity of the capsule shell solution, even if the amount of water is increased (90 to 200 parts by weight with respect to 100 parts by weight of starch) and the capsule shell solution is charged with a low viscosity, Capable of drying the adhesive surface uniformly and uniformly to an appropriate water content, preventing capsule foam failure, increasing capsule filling speed, and improving productivity and cost. It is possible to improve hardness stability by preventing a decrease in hardness over time after formation.

It is the perspective view which shows the soft capsule manufacturing apparatus (filling machine) used by this invention, and explanatory drawing which shows the drying apparatus by medium wavelength infrared irradiation from the front. It is a front view which shows the manufacturing apparatus (filling machine) used by this invention. It is a perspective view which expands and shows the drying apparatus by medium wavelength infrared irradiation. It is a front view which shows a mode that a soft capsule is manufactured with a pair of die roll. It is a top view which shows a pair of die roll. A front view of a filling machine showing a single-sided drying in which a drying device by mid-wavelength infrared irradiation is provided on the side of the casting drum (particularly without a transfer path) and the outer sheet is dried, and a drying device part It is a right view shown. FIG. 4 is a front view of a filling machine showing double-sided drying in which a drying transfer path by mid-wavelength infrared irradiation is provided in four stages so that the front and back surfaces of the outer sheet can be dried (irradiated) twice each. It is a front view which shows the Example which supported the outer skin sheet | seat during drying from the downward direction by the conveyor.

BEST MODE FOR CARRYING OUT THE INVENTION The best mode for carrying out the present invention includes one described in the following examples, and further includes various methods that can be improved within the technical idea.
In the description, first, the basic structure of the soft capsule 1 according to the present invention will be described, and then an example of a device for manufacturing the soft capsule 1 (device used in the present invention) will be described. Next, while explaining the operation mode of this apparatus, the production method of the soft capsule which is the method of the present invention will be explained together, and further the detailed explanation will be given while actually showing the component composition of the capsule shell.

[Basic structure of soft capsule]
The basic structure of the soft capsule 1 is, for example, as shown in FIG.
Here, as the contents N, materials for appropriate purposes such as foods, seasonings (seasoning oils), cosmetics, bathing agents, miscellaneous goods (toys, adhesives, etc.) can be used in addition to pharmaceuticals. In addition, the encapsulated state (accommodating state) includes a liquid form, a gel form, a granular body, or a state in which these are appropriately mixed, for example, a powder-containing suspension in which powder is mixed in a liquid. Is possible. In the following description, a case where the liquid content N is mainly stored will be described.
On the other hand, the outer skin part 2 can be based on animal-derived gelatin as in the past, but here, as described above, it is mainly composed of plant-derived starch, and specifically, Is formed by blending starch, λ carrageenan, metal salt, plasticizer, and water. The specific composition of these components will be described later.

[About manufacturing equipment]
Next, a soft capsule manufacturing apparatus 10 (hereinafter simply referred to as a filling machine 10) for manufacturing such a soft capsule 1 will be described. As the filling machine 10, a conventional rotary die type automatic soft capsule manufacturing machine can be diverted (followed), and as an example, as shown in FIG. 1, it is a raw material for forming a molten outer shell material (a raw material material for forming the outer skin portion 2). 2A), the contents N are encapsulated in the outer sheet S by joining the formed outer sheet S and the sheet forming part 11 formed into a sheet with an appropriate thickness while drying. A capsule forming part 12 for wrapping, a content supply part 13 for feeding the contents N in accordance with the joining of the outer skin sheet S, and a capsule take-out part 14 for taking out the formed soft capsule 1 from the filling machine 10. is there.
The present invention is characterized in that the sheet forming unit 11 is provided with a drying device 15 using medium wavelength infrared irradiation, and the drying ability is remarkably improved as compared with the conventional manufacturing method. Hereinafter, each component will be described.

First, the sheet forming part 11 will be described. This is a part that solidifies and forms the raw material 2A in the form of a sheet. In order to supply the two outer sheets S formed to the joining portion (between a pair of die rolls), A pair is provided on the left and right with the capsule forming part 12 in between. The sheet forming unit 11 includes a spreader box 21 that discharges the melted skin raw material 2A in a substantially constant sheet state, and a casting drum 22 that cools the skin sheet S discharged from the spreader box 21. The outer sheet S is formed into a sheet having an appropriate thickness while being cooled to an appropriate temperature. A method for dissolving the outer shell raw material 2A will be described later.

Here, the drying device 15 will be described. The drying device 15 is for drying the skin sheet S solidified into a sheet form from the skin raw material 2A and adjusting it to a desired moisture content. The reason why the moisture content is adjusted by applying such drying to the outer sheet S is to improve the adhesiveness (bondability) between the sheets in the subsequent bonding. Furthermore, hardness stability over time after capsule formation can be prevented and hardness stability can be improved. Further, in the embodiment shown in FIG. 1, in the drying apparatus main body 15A formed above the casting drum 22, both surfaces of the outer sheet S are separately irradiated with medium wavelength infrared rays to dry the outer sheet S. Yes (this is double-sided drying). Incidentally, here, the surface not directly attached to the casting drum 22 is first dried (this is referred to as front surface drying for convenience), and then the surface directly attached to the casting drum 22 is dried (this) For the sake of convenience) In addition, when these front surface drying / back surface drying are viewed from another point of view, the surface corresponding to the outer side of the capsule in the state of the soft capsule 1 finally becomes the front surface drying, and the surface corresponding to the inner side of the capsule, that is, the contents Drying the surface in direct contact with N is the back surface drying.

Further, in this embodiment, the outer sheet S is peeled off from the casting drum 22 and separately dried while being transported by the feed roll 23, and this transport path is denoted by 24. That is, the transfer path 24 for both the front surface drying and the back surface drying is formed by inverting the front and back of the outer sheet S by the feed roll 23, and maintains a certain distance from above the sheet (front and back). Then, the medium wavelength infrared ray is irradiated. For this reason, each transfer path 24 is provided with a medium-wavelength infrared heater 25 that emits medium-wavelength infrared light, and a reflector 26 is provided below the heater with the outer sheet S sandwiched between them. Also on the side, some drying action is intended to improve thermal efficiency.
Here, four (four) medium-wavelength infrared heaters 25 are installed for each of the front and back surfaces, but not all of them may be used. What is necessary is just to irradiate the outer sheet | seat sheet S with an appropriate energy amount using a required number according to a mixing | blending, a desired dry moisture content value, etc.

Moreover, since the outer sheet | seat S also receives heating by irradiation of mid-wavelength infrared rays simultaneously with drying, it tends to cause thermal deformation during drying (the heater temperature is about 900 ° C. as an example). That is, since the outer sheet S is always pulled in the feed direction (transfer direction) by the transfer, it is easily deformed so as to extend in the feed direction (longitudinal direction) by heating, and the width direction (depth direction) perpendicular thereto. ) Is easy to deform so as to shrink. Since the elongation in the longitudinal direction is likely to appear as a sag due to the weight of the skin sheet S itself, a support 27 such as a roller is provided below the skin sheet S in order to prevent this sag.
In the figure, reference numerals (A and B) added to the transfer path 24, the medium wavelength infrared heater 25, and the like are those acting on the surface on which they act, that is, on the front side of the skin sheet S. “A” is applied to the back side, and “B” is added to it.

In order to prevent excessive heating of the outer skin sheet S during drying, the surface of the outer skin sheet S (that is, the irradiation surface of the medium wavelength infrared rays) is blown along the air. This blowing is performed in the same direction as the sheet feeding direction, that is, from the upstream side to the downstream side in the transport direction. Thereby, the outer sheet S is appropriately cooled, the air flow in the transfer path 24 is stabilized (a kind of rectifying action), and deformation such as sagging can be further prevented.
In this embodiment, the air blowing body 28 provided on the upstream side is a slit nozzle type that is elongated in the width direction of the skin sheet S, and air along the sheet surface is uniformly distributed from the opening. It is formed to exhale. On the other hand, the air suction body 29 provided on the downstream side is formed so that the opening is larger than the air blowing body 28 and can be sucked in a wide range.
Further, as described above, since the temperature of the transfer path 24 and the outer sheet S tends to rise during drying, the thermometer 30 is provided below the medium wavelength infrared heater 25 (directly below the outer sheet S). It is considered that temperature management can be performed.

For the operator who operates the filling machine 10 or monitors the operation of the filling machine 10, it is preferable not to look directly at the light emitted from the medium wavelength infrared heater 25 (medium wavelength infrared light). As shown in the enlarged view of FIG. 2, it is preferable to provide a cover 31 that can move up and down on the side surface of the drying device 15 to actively block the irradiation light from the medium wavelength infrared heater 25. Incidentally, when the cover 31 is moved up and down, as shown in FIG. 1, two slits 32 in the vertical direction are formed in the cover 31 in advance, and the apparatus frame (dryer main body 15A) is formed through the slits 32. The butterfly bolt 33 is screwed together, and the cover 31 is moved up and down by fastening (screwing) / loosing (release) the butterfly bolt 33 and fixed.
Further, it is preferable to provide a cover 34 as shown in FIG. 3 at a portion where the transfer path 24 is reversed, that is, a portion where the air blowing body 28 and the air suction body 29 are provided. This is because the inside of the apparatus main body 15A is partitioned from the external space (manufacturing room) to be a partitioned space. That is, by partitioning the inside of the drying apparatus main body 15A by the covers 31, 34, the air blowing along the sheet surface from the air blowing body 28 to the air suction body 29 can be performed more reliably (spreading of the blown air can be prevented), and drying. It is also possible to prevent dust and the like from adhering to the inner skin sheet S. The cover 34 shown in FIG. 3 is formed of a transparent material so that the inside can be seen from the outside during manufacture, and is formed so that it can be horizontally rotated in a folded state so that it can be folded compactly. .

The portion described above becomes the sheet forming portion 11, and thereafter, the capsule forming portion 12 is provided on the side to which the outer sheet S is supplied, and the feed roll is relayed between the two forming portions. 37 is provided. That is, the outer sheet S having an appropriate moisture content by the sheet forming unit 11 (drying device 15) is sent to the capsule forming unit 12 while passing between the plurality of feed rolls 37 in a zigzag manner.

Next, the capsule forming part 12 will be described. As an example, as shown in FIGS. 4 and 5, this includes a pair of left and right die rolls 38 as main members, and one of these die rolls 38 is fixed, and the other is configured to be able to approach and separate from the fixed die roll 38. Is done.
Each die roll 38 is provided with a molding recess 39 having an appropriate shape on its surface and a molding projection 40 on its peripheral edge. For example, a soft capsule 1 having a substantially spindle shape or a substantially spheroid shape is provided. In the case of molding, the molding recess 39 can be formed in an oval shape with a recessed central portion. However, in the case of the present embodiment mainly composed of starch, the shrinkage of the soft capsule 1 after the capsule molding becomes more intense than in the case where gelatin is the major component. Is formed. Then, the pair of die rolls 38 rotate in a state where the molding projections 40 substantially match each other, so that the outer sheet S supplied in a state of being entangled between the die rolls 38 is brought into contact with each other in a timely manner. Suture (joining) is performed.

In the present embodiment, since the liquid N is assumed as the content N to be accommodated (covered) in the outer skin portion 2, the injection pressure (hydraulic pressure) when the content N is fed toward the outer skin S ), The outer sheet S can be expected to be deformed along the molding recess 39. Therefore, the pocket portion P for receiving the content N can be naturally formed in the outer sheet S with the supply (delivery) of the content N without taking a particularly positive measure.
Of course, it is also possible to positively form the pocket portion P in the outer sheet S before supplying the contents N, and this is, for example, the suction hole 41 shown in FIGS. That is, in this case, the outer sheet S sent between the die rolls 38 is actively sucked by suction from the suction holes 41 formed in the bottom of each molding recess 39, and the inclusion liquid N is received. The pocket portion P is curved in advance. As another form of positively forming the pocket portion P, for example, the pocket portion P can be formed by embossing the outer sheet S before the contents N are supplied. is there. Incidentally, regarding the mechanism for sucking the skin sheet S to form the pocket portion P, the present applicant has already applied for a patent and has obtained a patent (Japanese Patent Laid-Open No. 10-2111257 (Patent No. 3211148)). And gelatin manufacturing method and manufacturing apparatus thereof).

Next, the content supply unit 13 will be described. This is to supply the contents N such as liquid to the skin sheet S before the sewing around the capsule is completed, more specifically, in accordance with the joining of the skin sheet S. Is a projecting segment 44 formed so as to sufficiently enter between the die rolls 38 as a main member.
As shown in FIG. 1 as an example, the content supply unit 13 is provided with a stock solution hopper 45 in the upper portion, and stores the stock solution (contents N) therein. And below the undiluted solution hopper 45, a pump unit 46 is provided, which is appropriately formed by combining a plurality of plungers, etc., and injecting the content N from a plurality of paths at a predetermined timing, pressure, etc. It is discharged from the segment 44 to the outer sheet S via the delivery pipe 47.

Next, the capsule take-out part 14 for taking out the soft capsule 1 after molding will be described below the die roll 38. For example, as shown in FIG. 4, the soft capsule 1 after molding often fits in the molding concave portion 39 of the die roll 38, and therefore, the scraping brush 50 provided so as to come into contact with the die roll 38. The soft capsule 1 thus scraped off is conveyed to the front surface of the filling machine 10 by a pair of forward conveyors 51 provided along the rotational axis direction of the die roll 38 (see FIG. 1). In addition, as shown in FIG. 1 as an example, a blank sheet S ′ after the soft capsule 1 has been punched is sandwiched between both sides and fed downward as it is between a pair of forward conveyors 51. Is adjustable). The free roller 52 is configured so that the soft capsule 1 remaining on the blank sheet S ′ can be discharged onto one of the forward conveyors 51 in consideration of the fact that the soft capsule 1 may remain on the blank sheet S ′. It is preferable that Moreover, after the soft capsule 1 is conveyed to the front surface of the filling machine 10 by the advance conveyor 51, the soft capsule 1 is further transferred to another conveyor 53 and conveyed to the next drying step.

As shown in FIG. 4, as an example, in the capsule forming unit 12, the two sheet sheets S are fed between the pair of die rolls 38, and at a predetermined timing from the segment 44 positioned above them. Content N is supplied. That is, the two outer sheets S supplied to the die roll 38 are individually stitched around the capsule (around the molding recess 39) one by one by the abutting action of a large number of molding protrusions 40 provided on the peripheral surface. go. At this time, since the outer sheet S is subjected to a pressure of, for example, about 150 to 200 kg by the molding protrusion 40, the stitched portion is effectively glued and stitched.

Then, the soft capsule 1 in which the surrounding stitches have been completed is dried after being taken out from the molding recess 39, the blank sheet S ′, etc. as described above. In this drying, a tumbler dryer (rotary drum dryer) is generally used due to the shape and properties of the soft capsule 1.

[About manufacturing method]
The soft capsule manufacturing apparatus 10 (filling machine 10) used in the present invention has the basic structure as described above. Hereinafter, the embodiment of manufacturing the soft capsule 1 by the filling machine 10 will be described together with the present invention. A method for producing a soft capsule, which is a method, will be described.
First, the aspect which mixes and supplies the outer skin component component (outer raw material 2A) of the soft capsule 1 to the filling machine 10 will be described.
Generally, in order to mix the shell raw material 2A of the soft capsule 1 and supply it to the filling machine 10, there are a method using a bucket-type heating and melting pot and a method of continuously supplying by an extruder, both of which are also used in the present invention. However, here, a method using a bucket type heating and melting pot will be described.

For example, when the non-animal-derived soft capsule 1 is manufactured, the heating and melting step of melting the outer shell raw material 2A is performed by placing starch, λ carrageenan, metal salt, plasticizer, and water in a heating and melting pot at 0.05 to 0.3 MPa. Under a pressure of (usually 0.2 MPa), the mixture is heated and dissolved at a temperature of 90 to 120 ° C. (usually 110 ° C.) for a time of 60 to 100 minutes (usually 80 minutes) while stirring at a rotational speed of 50 to 70 rpm.

Next, a two-stage defoaming process is performed. The defoaming process in the first stage is performed with a defoaming pressure of −400 to −600 mmHg (usually −500 mmHg), a defoaming pressure expressed as a degassing temperature of 100 to 110 ° C. (usually 105 ° C.), and an atmospheric pressure of 0 (zero). The foaming time is 15 to 70 minutes (usually 30 minutes). At this time, the first 5 to 15 minutes (usually 10 minutes) is rotated with a stirrer of 10 rpm, and then the deaeration is performed with the stirrer stopped.
The defoaming step in the second stage is performed by raising the defoaming temperature to 110 to 130 ° C. (usually 120 ° C.), and defoaming pressure −400 to −600 mmHg (usually −500 mmHg) in the gauge pressure notation where the atmospheric pressure is 0 (zero). Defoaming is performed with a defoaming time of 10 to 20 minutes (usually 15 minutes).
Here, the vacuum melting pot used in the heating and melting step and the defoaming step is not particularly limited. For example, a trade name: high viscosity vacuum stirrer (manufactured by Shoyu Machinery Co., Ltd., model: SY-HMD-200) is used. Can be used.
Moreover, it does not specifically limit as a vacuum pump used for a defoaming process, For example, a water seal type | formula vacuum pump (Kashiyama Kogyo Co., Ltd. make, model: LEH100Ms) can be used.
In addition, after defoaming, it is preferable that the obtained outer raw material 2A in a solution state is transferred to a pressure-resistant subdivision tank and heated and stored at 60 to 90 ° C. (usually 75 ° C.) for about 12 to 24 hours.

In the supply step of supplying the solution-state skin raw material 2A thus obtained to the filling machine 10, the skin raw material 2A is extruded from the subdivision tank under a pressure of 0.01 to 0.1 MPa (usually 0.05 MPa), It is stored in the spreader box 21 of the filling machine 10. Further, by adjusting the gap between the casting drum 22 and the spreader box 21, the outer sheet S having a constant thickness is created. The temperature of the casting drum 22 at this time is maintained at a constant temperature of 17 to 22 ° C. (normal temperature is 20 ° C.) by air cooling or water cooling.
The filling chamber humidity (manufacturing chamber humidity) at this time is maintained at a constant humidity of 20 to 26% RH (usually 23% RH), and the filling chamber temperature (manufacturing chamber temperature) is 22 to 27 ° C. (usually 25 ° C.). C)) is preferably maintained at a constant temperature.

Next, an aspect in which the skin sheet S obtained in this way is dried by the drying device 15 using medium wavelength infrared irradiation will be described.
The outer sheet S discharged from the spreader box 21 is placed on the casting drum 22 and rotated about ¾ yen (about 270 degrees), and then peeled off from the casting drum 22 and formed on the upper side thereof. 24, where it undergoes both-side drying by medium wavelength infrared irradiation. That is, the outer sheet S sent out from the casting drum 22 is first dried by the medium wavelength infrared heater 25A while passing through the transfer path 24A, and then reversed by the feed roll 23. This time, the back surface (inside the capsule) is dried by the medium wavelength infrared heater 25B, whereby both sides of the outer sheet S are dried.

Here, in the drying of the outer sheet S of the present invention, the moisture content of the outer sheet S is preferably 30 to 40%, more preferably 32 to 38% by the medium wavelength infrared energy emitted from the medium wavelength infrared heater 25. In particular, it is dried to 33 to 37% (moisture content is measured by Shimadzu Corporation trade name: MOISTURE BALANCE, model: MOC-120H). This is because when the moisture content of the skin sheet S is less than 30% or more than 40%, the adhesion between the skin sheets S and the hardness stability after the capsule formation tend to decrease, which is not preferable. .

The wavelength of the medium wavelength infrared ray emitted from the medium wavelength infrared heater 25 is preferably 0.8 to 4.0 μm, more preferably 1.3 to 3.0 μm, and particularly preferably 2.5 to 2.7 μm. Here, as the medium wavelength infrared heater 25, any medium wavelength infrared ray can be used as long as the wavelength of the emitted medium wavelength infrared ray satisfies the above conditions and is sold on the market. For example, trade name: medium wavelength infrared heater manufactured by Heraeus Co., Ltd., model number: MBS 1600/250 can be applied.

In the present invention, since what is irradiated to the outer sheet S is medium-wavelength infrared, heat penetrates into the sheet, and the moisture content in the thickness direction of the sheet can be made uniform. In addition, this provides a particularly advantageous effect in that the subsequent bonding with the die roll 38 can be performed very well, and the hardness stability after the capsule formation is improved by combining with the trisodium citrate compounding to the outer skin part. It is.
By the way, when hot air is simply applied to the outer sheet S and dried, only the surface of the outer sheet S is dried, so that a deviation (difference) in the moisture content occurs between the inside and the surface of the sheet, and the subsequent bonding is performed. There was a tendency that hardness could not be improved and hardness stability after capsule formation was lowered, and this was particularly remarkable when starch was the main component.

In the present embodiment, since the reflection plates 26A and 26B are provided below the medium wavelength infrared heaters 25A and 25B, the outer skin sheet S passing between the medium wavelength infrared heater 25 and the reflection plate 26 passes through. As a result, the thermal efficiency is improved.
In addition, the skin sheet S is easily deformed by heat from the heater during drying, but in this embodiment, the support 27 such as a roller prevents sagging due to heat.
Further, since air is flowed on the irradiation surface of the outer sheet S in the same direction as the sheet transfer direction, an excessive increase in the sheet temperature is prevented.

The skin sheet S thus dried and adjusted to an appropriate moisture content is then fed into the capsule forming part 12 (between the die rolls 38) via the feed roll 37 and joined there. Further, along with this, the contents N are supplied to the skin sheet S at the joining portion, and the soft capsule 1 containing the contents N is formed in the skin part 2. As described above, the soft capsule 1 formed in this manner is fitted into the molding recess 39 of the die roll 38 or remains in the blank sheet S ′, and is thus taken out and dried.

The capsule filling speed is usually represented by the number of revolutions of the die roll 38 (die) (rpm: revolution per minute). In the production of the non-animal derived soft capsule 1 using starch, λ carrageenan, metal salt, plasticizer, and water, even if the rotational speed of the die roll 38 (mold) is increased by the drying device 15 by the medium wavelength infrared irradiation. Since the moisture content of the outer sheet S can be adjusted, it is possible to increase the productivity by increasing the rotational speed of the die roll 38 (mold).

[Other Examples]
The present invention has the above-described embodiment as one basic technical idea, but the following modifications can be considered. That is, in the embodiment described above, the transfer paths 24A and 24B acting on the front and back surfaces of the outer sheet S are separately formed, and the medium wavelength infrared heaters 25A and 25B are irradiated with the medium wavelength infrared rays in these. The both sides of the skin sheet S were dried. However, when the skin sheet S can be sufficiently dried to the inside of the sheet only by irradiation from one side, it may be dried by either one of the transfer paths 24A and 24B.
Of course, if the sheet can be uniformly dried by such single-sided drying, it is not necessary to reversely form the transfer path 24A, and after the outer sheet S is peeled from the casting drum 22, the joining portion (a pair of die rolls) It is also possible to form a transfer path 24 for drying (irradiation) until it is fed to (between 38) and irradiate it with medium-wavelength infrared rays for drying.

Furthermore, when drying can be performed by single-sided drying, it is possible to dry the outer sheet S without providing the transfer path 24 separately. As such a dry form, for example, as shown in FIG. 6, in the vicinity of the casting drum 22 (here, a position rotated about 1/4 circle (about 90 degrees) after being discharged from the spreader box 21), a medium wavelength is used. An infrared heater 25 is provided and is dried at a stage where the outer sheet S is placed on the casting drum 22 (a stage before being peeled from the casting drum 22).

Incidentally, it is considered that the filling machine 10 shown in FIG. 6 is suitable for manufacturing a soft capsule 1 mainly composed of conventional gelatin. If gelatin is the main component, it may be possible to sufficiently dry even if it does not have a drying capability as high as that of the medium wavelength infrared ray. This is because the conventional dry form, that is, the form in which only one side of the capsule skin sheet S (the outside of the capsule) is dried with only the casting drum 22 (water content is 19 to 23%) can be obtained.
It may seem that the single-sided drying on the casting drum 22 is similar to a conventional rotary die type automatic soft capsule manufacturing machine, but in the present invention, it is irradiation with medium-wavelength infrared rays and not mere air blowing. Therefore, the non-animal derived skin sheet S containing starch, λ carrageenan, metal salt, plasticizer, and water can be sufficiently dried, and the adhesiveness of the skin sheet S can be enhanced. Furthermore, hardness stability over time after capsule formation can be prevented and hardness stability can be improved. It is also possible to freely dry both sides of the outer sheet S.

On the other hand, there are cases where the initial moisture content is high or higher drying capacity is required for such single-sided drying. For this reason, in such a case, 24A and 24B shown in FIG. 1 are further formed in the filling machine 10 shown in FIG. 6, and drying on the casting drum 22 (single-sided drying) is performed. It is possible to perform both of taking out and drying (double-sided drying).
Furthermore, when a higher drying capacity is required, for example, as shown in FIG. 7, the transfer path 24 in double-sided drying is formed in three or more stages, and for example, the front surface and the back surface are dried twice each. It is possible to do it one by one.
Of course, even when the medium-wavelength infrared heater 25 is provided in three or more stages as described above, it is not always necessary to operate (operate) the medium-wavelength infrared heater 25 at all stages for drying. Naturally, it is possible to allow only necessary portions to act in accordance with the composition component of the outer shell raw material 2A and the desired moisture content value to be dried.

1 to 3, the roller is applied as the support 27 that receives the outer sheet S irradiated with the medium wavelength infrared rays from below. However, the support 27 is not necessarily limited to the roller. For example, as shown in FIG. 8, a conveyor or the like can be applied. The conveyor here is naturally driven at the same transfer speed as the outer sheet S.

Next, the present invention will be described in more detail with reference to more detailed examples. However, the present invention is not limited to these examples, and vegetable oils, animal oils, combinations of vegetable oils and animal oils, and various fats and oils are also described. It can be applied to all those that can be encapsulated with a mixture of various fats and oils such as suspension oils containing animal and plant extracts and extract powders.
Prior to the description of the comparative examples and examples, the evaluation items and the evaluation methods used in the comparative examples and examples will be described.

(1) Adhesive evaluation Visual evaluation was performed with a microscope, and determination was made as follows.
◎: Very good adhesion, ○: Good adhesion, △: Poor adhesion, ×: No adhesion (2) Liquid leakage evaluation After leaving 1000 capsules for 12 hours, the capsule contents are leaking “Liquid leakage The liquid leakage rate was calculated as a percentage.
(3) Foam failure evaluation The number of spheres in which the capsules with poor foam that can be visually confirmed to have bubbles were found in 1000 capsules was calculated, and the bubble failure rate was calculated as a percentage.
(4) Hardness stability evaluation After the capsule moisture was adjusted to 6-8%, the hardness average value of 10 capsules on the 1st, 7th and 30th days was measured using a Kiya-type hardness meter (manufactured by Fujiwara Seisakusho Co., Ltd.). The maximum weight 50 kg) was calculated and determined as follows. The higher the hardness value, the stronger the strength against pressure.
◎: very good hardness stability, ○: good hardness stability, △: poor hardness stability, x: very poor hardness stability (5) Overall evaluation (1) Adhesive evaluation described above ( Based on 2) liquid leakage evaluation, (3) bubble defect evaluation, and (4) hardness stability evaluation, comprehensive evaluation was performed, and the following determination was made.
◎: Very good, ○: Good, △: Slightly inferior, ×: Bad

[Comparative Example 1, Comparative Example 2, Comparative Example 3]
The capsule shell components shown in Table 1 are placed in a heating and melting pot and melted by heating at a melting temperature of 110 ° C. for 80 minutes while stirring at a rotational speed of 50 to 70 rpm under a pressure of 0.2 MPa.
Next, a two-stage defoaming process is performed. The defoaming step in the first stage is performed at a defoaming temperature of 105 ° C. and a defoaming pressure of −500 mmHg and a defoaming time of 30 minutes in terms of gauge pressure with the atmospheric pressure being 0 (zero). At this time, the first 10 minutes is rotated with a stirrer of 10 rpm, and then the deaeration is performed with the stirrer stopped. In the second defoaming step, the defoaming temperature is raised to 120 ° C., and the defoaming pressure is degassed in a gauge pressure notation of −500 mmHg with a defoaming time of 15 minutes. The soft capsule shell solution obtained after defoaming was transferred to a small tank and stored at 75 ° C. for about 15 hours for use.
As a filling machine, a conventional rotary die type automatic soft capsule manufacturing machine was used. The obtained soft capsule skin solution was discharged from a spreader box and spread on cooling drums on both sides of the filling machine to form a sheet (outer sheet). The outer skin sheet was guided to a filling machine, and immediately after the contents (mixture of 70% by weight of MCT and 30% by weight of lecithin) were filled, a soft capsule was obtained by pressure bonding with a die (die roll).
<Filling conditions>
Casting drum temperature: 20 ° C
Segment temperature: 30 ° C
Die roll rotation speed: 1.5 rpm in Comparative Example 1 and Comparative Example 2
In Comparative Example 3, 3.0 rpm
Filling room humidity: 24% RH
Filling chamber temperature: 26 ° C

[Comparative Example 4]
The capsule shell components shown in Table 1 are placed in a heating and melting pot and melted by heating at a melting temperature of 110 ° C. for 80 minutes while stirring at a rotational speed of 50 to 70 rpm under a pressure of 0.2 MPa.
Next, a two-stage defoaming process is performed. The defoaming step in the first stage is performed at a defoaming temperature of 105 ° C. and a defoaming pressure of −500 mmHg and a defoaming time of 30 minutes in terms of gauge pressure with the atmospheric pressure being 0 (zero). At this time, the first 10 minutes is rotated with a stirrer of 10 rpm, and then the deaeration is performed with the stirrer stopped. In the second defoaming step, the defoaming temperature is raised to 120 ° C., and the defoaming pressure is degassed in a gauge pressure notation of −500 mmHg with a defoaming time of 15 minutes.
The soft capsule shell solution obtained after defoaming was transferred to a small tank and stored at 75 ° C. for about 15 hours for use.
As the filling machine, a soft capsule manufacturing machine provided with a capsule skin sheet drying apparatus by infrared irradiation with medium wavelength, which is an apparatus developed by the present inventors, was used.
The obtained soft capsule skin solution was discharged from a spreader box and spread on cooling drums 22 on both sides of the filling machine 10 to form a sheet (outer sheet S). While drying the skin sheet S to a moisture content of 32% with a medium wavelength infrared heater, the skin sheet S is guided to the filling machine 10 and the contents (mixture of 70% by weight of MCT and 30% by weight of lecithin) are obtained. Immediately after filling, the soft capsule 1 was obtained by pressure bonding with a die (die roll 26).
<Filling conditions>
Casting drum temperature: 20 ° C
Medium wavelength infrared heater
(Manufactured by Heraeus Co., Ltd., model number: MBS1600 / 250): wavelength 2.6 μm
Segment temperature: 30 ° C
Die roll rotation speed: 3.0rpm
Filling room humidity: 24% RH
Filling chamber temperature: 26 ° C

[Example 1 / Example 2 / Example 3]
As shown in Table 1, the capsule shell component containing trisodium citrate as a metal salt was placed in a heated dissolution kettle and stirred at a pressure of 0.2 MPa while stirring at a rotating speed of 50 to 70 rpm. Dissolve by heating at 110 ° C. for 80 minutes.
Next, a two-stage defoaming process is performed. The defoaming step in the first stage is performed at a defoaming temperature of 105 ° C. and a defoaming pressure of −500 mmHg and a defoaming time of 30 minutes in terms of gauge pressure with the atmospheric pressure being 0 (zero). At this time, the first 10 minutes is rotated with a stirrer of 10 rpm, and then the deaeration is performed with the stirrer stopped. In the second defoaming step, the defoaming temperature is raised to 120 ° C., and the defoaming pressure is degassed in a gauge pressure notation of −500 mmHg with a defoaming time of 15 minutes.
The soft capsule shell solution obtained after defoaming was transferred to a small tank and stored at 75 ° C. for about 15 hours for use.
As the filling machine 10, a soft capsule manufacturing machine provided with a capsule skin sheet drying apparatus using medium wavelength infrared irradiation, which is an apparatus developed by the present inventors, was used.
The obtained soft capsule outer skin solution (outer raw material 2A) was spread on the cooling drums 22 on both sides of the filling machine 10 to form a sheet (outer sheet S). While drying the skin sheet S to 32% by the medium wavelength infrared heater 25, the skin sheet S is guided to the filling machine 10 and the contents (mixture of 70% by weight of MCT and 30% by weight of lecithin). Immediately after filling, a soft capsule 1 was obtained by pressure bonding with a mold (die roll 38).
<Filling conditions>
Casting drum temperature: 20 ° C
Medium wavelength infrared heater
(Manufactured by Heraeus Co., Ltd., model number: MBS1600 / 250): wavelength 2.6 μm
Segment temperature: 30 ° C
Die roll rotation speed: 3.0rpm
Filling room humidity: 24% RH
Filling chamber temperature: 26 ° C

[Comparative Example 1, Comparative Example 2, Comparative Example 3 Evaluation Results]
As shown in Comparative Example 1, when the water content of the capsule shell solution was 80 parts by weight with a conventional rotary die type automatic soft capsule manufacturing machine (die roll rotation speed: 1.5 rpm), it was dissolved in the capsule shell solution. It was difficult for air to escape and the capsule foam defect rate increased.
On the other hand, as shown in Comparative Example 2, when the amount of water in the capsule shell solution was 150 parts by weight with a conventional rotary die type automatic soft capsule manufacturing machine (die roll rotation speed: 1.5 rpm), it was removed from Comparative Example 1. Although the foamability was improved and the foam defect rate was low, there was a capsule in which the capsule adhesiveness was poor and the capsule contents (mixture of 70% by weight of MCT and 30% by weight of lecithin) leaked.
As shown in Comparative Example 3, the same amount of water as the capsule shell raw material as in Comparative Example 2 is 150 parts by weight, and the rotational speed of the die roll is increased from 1.5 rpm to 3.0 rpm with a conventional rotary die type automatic soft capsule manufacturing machine. The capsule adhesion surface did not adhere sufficiently, and the capsule contents (mixture of 70% by weight of MCT and 30% by weight of lecithin) leaked immediately after the capsule formation, and the liquid leakage rate was high.

[Comparative Example 4 Evaluation Results]
In Comparative Example 4 in which trisodium citrate was not blended but sodium dihydrogen phosphate and potassium chloride were blended, a soft capsule provided with a capsule skin sheet drying device by mid-wavelength infrared irradiation, which was developed by the present inventors When using the manufacturing equipment, compared with Comparative Examples 1, 2, and 3, even if the die roll speed is doubled from 1.5 to 3.0 rpm, the bubble defect rate is low, the adhesion is very good, and the liquid capsule does not leak Can be manufactured.
However, a decrease in hardness over time after capsule formation has occurred, and the problem of hardness stability remains unsolved.

[Evaluation results of Example 1, Example 2, Example 3]
In Example 1, Example 2, and Example 3 in which trisodium citrate was blended, when a soft capsule manufacturing apparatus provided with a capsule skin sheet drying apparatus by mid-wavelength infrared irradiation, which was developed by the present inventors, was used. Compared with Comparative Examples 1, 2, and 3, even when the die roll speed is doubled from 1.5 to 3.0 rpm, a soft capsule that has a low bubble defect rate, very good adhesion, and does not leak can be manufactured. It was.
Further, even after using a soft capsule manufacturing apparatus equipped with a capsule skin sheet drying apparatus using medium wavelength infrared irradiation, which was an apparatus developed by the present inventors as in Comparative Example 4, time elapsed after capsule formation. No decrease in hardness occurred in Examples 1, 2, and 3, and the hardness stability could be improved.

Here, in producing the soft capsule 1, the difficulty when the starch is the main ingredient as the outer skin raw material 2A (difficulty compared with the case where the gelatin is the main ingredient) will be described. When starch is the main component, it is necessary to improve the drying capacity of the filling machine 10 as described above. For this purpose, for example, a long transfer path 24 is simply formed to dry for a long time. It is not enough to just do it. The drying is accompanied by deformation due to heat, and in particular, when the transfer path 24 is formed longer, the corresponding amount (the longer it is formed), the tension (pulling force) applied to the outer sheet S for transfer. This is because the soft capsule 1 in a completed state is easily deformed. Specifically, it is considered that the size of the molding recess 39 of the die roll 38 is substantially the same as that of the completed soft capsule 1, but (when gelatin is the main component, the completed soft capsule 1 is In the soft capsule 1 in which starch is the main component, the soft capsule 1 is formed in substantially the same size), and contracts more greatly in the rotational direction of the die roll 38 (feeding direction of the outer sheet S) than the actual size of the molding recess 39 (for example, FIG. As shown by the two-dot chain line in the enlarged view, it shrinks by about 10 to 30%), making it much more difficult to manufacture compared to the case where gelatin is the main component.

The present invention can be used in the fields of “pharmaceuticals”, “special health foods”, “so-called health foods” and foods, as well as in industrial fields such as those containing industrial preparations depending on the selection of contents. it can.

DESCRIPTION OF SYMBOLS 1 Soft capsule 2 Outer part 2A Outer raw material 10 Soft capsule manufacturing apparatus (filling machine)
DESCRIPTION OF SYMBOLS 11 Sheet shaping | molding part 12 Capsule shaping | molding part 13 Content supply part 14 Capsule taking-out part 15 Drying apparatus 15A Drying apparatus main body 21 Spreader box 22 Casting drum 23 Feed roll 24 Transfer path 24A Transfer path (front side side)
24B Transfer path (back side)
25 Medium Wavelength Infrared Heater 25A Medium Wavelength Infrared Heater (Front Side)
25B Mid-wave infrared heater (back side)
26 Reflector 26A Reflector (front side)
26B Reflector (back side)
27 Support body 28 Air blowout body 29 Air suction body 30 Thermometer 31 Cover 32 Slit 33 Butterfly bolt 34 Cover 37 Feed roll 38 Die roll 39 Molding recess 40 Molding projection 41 Suction hole 44 Segment 45 Stock solution hopper 46 Pump unit 47 Delivery pipe 50 Scratch Take Brush 51 Forward Conveyor 52 Free Roller 53 Conveyor N Contents P Pocket Part S Outer Sheet S 'Blank Sheet

Claims (8)

1. The outer sheet is supplied in a face-to-face state between a pair of die rolls, and the outer sheet is joined by the butt action of the die rolls, and the contents are supplied to the outer sheet in accordance with the bonding. In a method of manufacturing a soft capsule containing contents inside a part,
   The outer skin part is formed by blending starch, λ carrageenan, metal salt, plasticizer, and water as a constituent component composition of raw materials,
   The amount of λ carrageenan in the outer skin part is 5 to 25 parts by weight with respect to 100 parts by weight of starch in the solution stage before drying,
   The amount of the metal salt in the outer skin part is 1 to 20 parts by weight with respect to 100 parts by weight of starch in the solution stage before drying,
   The skin sheet is dried by medium-wavelength infrared rays until it is joined by a pair of die rolls, thereby forming a sheet having a substantially constant thickness, moderate viscosity, and moisture content. A method for producing soft capsules.
2. The metal salt is trisodium citrate;
   The method for producing a soft capsule according to claim 1, wherein the wavelength of the medium wavelength infrared ray irradiated for drying the outer skin sheet is 0.8 to 4.0 µm.
3. The skin sheet is preferably dried to a moisture content of 30 to 40%, more preferably 32 to 38% when it is fed between a pair of die rolls by drying by infrared irradiation with medium wavelength infrared rays. The manufacturing method of the soft capsule of Claim 1 or 2.
4. A method for producing a soft capsule, characterized in that a decrease in hardness over time is suppressed by the method for producing a soft capsule according to claim 1, 2 or 3.
5. The ratio to λ carrageenan further comprises κ carrageenan and ι carrageenan of λ carrageenan: κ carrageenan: ι carrageenan = 1: 0.1: 0.1 to 1: 4: 4, 2. A method for producing a soft capsule according to 2, 3 or 4.
6. The metal salt is selected from the group consisting of trisodium citrate, sodium succinate, sodium gluconate, disodium hydrogen phosphate, sodium dihydrogen phosphate, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, calcium lactate. 6. The method for producing a soft capsule according to claim 1, 2, 3, 4 or 5, wherein the soft capsule is one kind or a combination of two or more kinds.
7. The outer sheet is supplied in a face-to-face state between a pair of die rolls, and the outer sheet is joined by the butt action of the die rolls, and the contents are supplied to the outer sheet in accordance with the bonding. In a method of manufacturing a soft capsule containing contents inside a part,
   The temperature of the segment part for applying heat to the outer sheet when the outer sheet is joined by the butt action of the die roll is 30 to 40 ° C, A method for producing a soft capsule according to 5 or 6.
8. Soft capsules produced by the method for producing soft capsules according to claim 1, 2, 3, 4, 5, 6 or 7.

Images