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WO2011051976A3 - Process for the preparation of clopidogrel bisulfate form i - Google Patents

Process for the preparation of clopidogrel bisulfate form i Download PDF

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Publication number
WO2011051976A3
WO2011051976A3 PCT/IN2010/000710 IN2010000710W WO2011051976A3 WO 2011051976 A3 WO2011051976 A3 WO 2011051976A3 IN 2010000710 W IN2010000710 W IN 2010000710W WO 2011051976 A3 WO2011051976 A3 WO 2011051976A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
clopidogrel
clopidogrel bisulfate
bisulfate form
free base
Prior art date
Application number
PCT/IN2010/000710
Other languages
French (fr)
Other versions
WO2011051976A2 (en
Inventor
Ramakoteswara Rao Jetti
Aggi Rami Reddy Bommareddy
Anjaneya Raju Indukuri
Debashish Datta
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2011051976A2 publication Critical patent/WO2011051976A2/en
Publication of WO2011051976A3 publication Critical patent/WO2011051976A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to an improved process for the preparation of Clopidogrel bisulfate Form I from clopidogrel free base. Clopidogrel free base is isolated from Clopidogrel acid addition salt.
PCT/IN2010/000710 2009-10-30 2010-10-29 An improved process for the preparation of clopidogrel bisulfate form i WO2011051976A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2637/CHE/2009 2009-10-30
IN2637CH2009 2009-10-30

Publications (2)

Publication Number Publication Date
WO2011051976A2 WO2011051976A2 (en) 2011-05-05
WO2011051976A3 true WO2011051976A3 (en) 2011-07-14

Family

ID=43607938

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000710 WO2011051976A2 (en) 2009-10-30 2010-10-29 An improved process for the preparation of clopidogrel bisulfate form i

Country Status (1)

Country Link
WO (1) WO2011051976A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2818540A1 (en) * 2013-06-26 2014-12-31 Barokes PTY Ltd. Beverage container coated with a resveratrol layer
CN104211714B (en) * 2014-08-14 2016-09-14 广东东阳光药业有限公司 A kind of preparation method of anticoagulant
KR101710922B1 (en) 2015-06-03 2017-02-28 경동제약 주식회사 Method for preparing crystalline form I of Clopidogrel hydrogen sulfate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005100364A1 (en) * 2004-04-19 2005-10-27 Krka, Tovarna Zdravil, D.D. Novo Mesto Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form i
WO2007102037A2 (en) * 2006-03-09 2007-09-13 Richter Gedeon Nyrt. A PROCESS FOR THE PREPARATION OF POLYMORPH FORM I OF (S)-(+)-METHYL-α-(2-CHLOROPHENYL)-6,7-DYHIDRO-THIENO-[3,2-c]PYRIDINE-5(4H)-ACETATE HYDROGEN SULFATE
WO2008034912A2 (en) * 2006-09-22 2008-03-27 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the synthesis of clopidogrel and new forms of pharmaceutically acceptable salts thereof
WO2008118030A1 (en) * 2007-03-23 2008-10-02 Tomasz Kozluk Process for preparation of pure polymorphic form 1 of clopidogrel hydrogensulfate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (en) 1987-02-17 1992-01-24 Sanofi Sa ALPHA SALTS- (TETRAHYDRO-4,5,6,7 THIENO (3,2-C) PYRIDYL-5) (2-CHLORO-PHENYL) -THETHYL ACETATE DEXTROGYRE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2779726B1 (en) 1998-06-15 2001-05-18 Sanofi Sa POLYMORPHIC FORM OF CLOPIDOGREL HYDROGENOSULFATE
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
CZ297472B6 (en) 2002-08-27 2006-12-13 Zentiva, A.S. Process for preparing crystalline form I of clopidogrel hydrogen sulfate
AU2003285841A1 (en) 2002-11-28 2004-06-18 Anpharm Przedsiebiorstwo Farmaceutyczne S.A. A process for the preparation of crystalline form 1 or clopidogrel hydrogen sulfate
US20060047121A1 (en) 2004-09-01 2006-03-02 Sawant Kamlesh D Novel process for preparation of clopidogrel bisulfate polymorph - Form I

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005100364A1 (en) * 2004-04-19 2005-10-27 Krka, Tovarna Zdravil, D.D. Novo Mesto Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form i
WO2007102037A2 (en) * 2006-03-09 2007-09-13 Richter Gedeon Nyrt. A PROCESS FOR THE PREPARATION OF POLYMORPH FORM I OF (S)-(+)-METHYL-α-(2-CHLOROPHENYL)-6,7-DYHIDRO-THIENO-[3,2-c]PYRIDINE-5(4H)-ACETATE HYDROGEN SULFATE
WO2008034912A2 (en) * 2006-09-22 2008-03-27 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the synthesis of clopidogrel and new forms of pharmaceutically acceptable salts thereof
WO2008118030A1 (en) * 2007-03-23 2008-10-02 Tomasz Kozluk Process for preparation of pure polymorphic form 1 of clopidogrel hydrogensulfate

Also Published As

Publication number Publication date
WO2011051976A2 (en) 2011-05-05

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