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WO2010112558A1 - Dispositif d'administration de médicaments muni d'une fenêtre d'indication de dose - Google Patents

Dispositif d'administration de médicaments muni d'une fenêtre d'indication de dose Download PDF

Info

Publication number
WO2010112558A1
WO2010112558A1 PCT/EP2010/054337 EP2010054337W WO2010112558A1 WO 2010112558 A1 WO2010112558 A1 WO 2010112558A1 EP 2010054337 W EP2010054337 W EP 2010054337W WO 2010112558 A1 WO2010112558 A1 WO 2010112558A1
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
delivery device
window
housing
dosage
Prior art date
Application number
PCT/EP2010/054337
Other languages
English (en)
Inventor
Michael Harms
Steffen Raab
Uwe Dasbach
Udo Stauder
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of WO2010112558A1 publication Critical patent/WO2010112558A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126—Specific display means related to dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback

Definitions

  • the present invention relates to a drug delivery device. Particularly, the present invention relates to a drug delivery device with improvements to displaying a scheduled dosage.
  • Drug delivery devices are generally known for the administration of a medicinal prod- uct, for example insulin, growth hormones or other drugs, being suitable for self- administration by a patient.
  • Some drug delivery devices are configured to deliver a plurality of different doses.
  • One particular example of such drug delivery device is described in EP 1 923 084 A1.
  • the drug delivery device shown therein allows a user to activate the delivery device.
  • the drug delivery device includes a drive mechanism suitable for use in pen-type injectors, where an amount of pre-set doses of medicinal product can be administered.
  • a needle unit can be attached to the drug delivery device for dispensing the medicinal product into a patient's body. After usage of the drug delivery device, the needle unit can be replaced and the distal end of the device can be covered by a cap.
  • the number of doses stored in a pen-type injector exceeds the dosage of a single treatment. Therefore, some drug delivery devices are configured to allow an adjustment or selection of different dose sizes, which are to be delivered. However, it is generally advisable that the patient or the user is aware of the amount of medicinal product which is selected to be dispensed in the patient's body or which is left in the injection device.
  • Document US 2001/0053894 shows a dose display for a medicine administration de- vice, in which rotation of the dose setting actuator is transmitted to a display means.
  • the setting actuator comprises a flexible disk carrying numbers in a band along its pe- rimeter, which numbers are in accordance with the set dosage presented in a window of the device to show that dosage.
  • the visibility of dosage selected for dispense into the patient's body or the amount of drug still left in the injection device should be guaranteed even if the drug delivery device is frequently used.
  • a drug delivery device comprises a housing having a proximal end and an outer surface.
  • a dose dial sleeve comprises a plurality of symbols that symbols representing dosage information during operation of the drug delivery device.
  • the dose dial sleeve is in operative connection with a dose dial grip to select a dosage to be delivered.
  • the drug delivery device comprises a dose button in operative connection with a piston rod to deliver the drug in response to the selected dosage.
  • the drug delivery device comprises a window aperture in the housing such that at least one symbol repre- senting dosage information is visible, wherein the window aperture is recessed in the housing with respect to the outer surface. Consequently the window is recessed as well with respect to the outer surface of the housing.
  • the recess distance between the outer surface of the housing and a surface of the window may be 10 % to 70 % of the housing's thickness.
  • the recess may preferably be 10 % to 50 % of the thickness of the housing.
  • the recess of the window aperture in the housing with respect to the outer surface protects the window and the window material from being scratched or damaged during usage or storing of the drug delivery device. Particularly, sliding, gliding or rolling of the drug delivery device on a surface does not scratch or damage the surface of the window aperture causing abrasion or scratches in the window material.
  • the at least one symbol shown in the window aperture corresponds to the dosage selected by the dose dial grip and the dose dial sleeve. The user may select the desired amount of dosage by moving or rotating the dose dial grip until the respective symbol corresponding to the desired dosage is visible in the window aperture.
  • the dose dial grip is arranged at the proximal end of the housing.
  • the window aperture may be arranged close to the proximal end of the hous- ing. Consequently, visibility during selection of the dosage to be delivered is improved.
  • the window aperture may comprise transparent plastic or glass or any other transparent substantially scratch-resistant material on its outer surface.
  • the scratch-resistant material prevents or reduces damage due to gliding or scratching of the drug delivery device along a protrution able to penetrate the recess..
  • the plurality of symbols may comprise consecutive numbers so as to indicate dosage to be delivered or remaining dosages left.
  • the housing of the drug delivery device may comprise markings on its outer surface close to the window aperture to indicate the dosage selected.
  • the numbers may be printed or molded on the dial button sleeve.
  • the housing comprises priming information suitable for providing additional information to a user.
  • the piston rod of the drug delivery device is a linearly movable piston rod.
  • the piston rod is a rotationally movable piston rod.
  • FIG. 1 schematically shows a simplified cross-sectional side view of a drug delivery device according to an embodiment
  • FIG. 2 schematically shows a simplified side view of a part of a drug delivery device according to an embodiment
  • FIG. 3 shows a simplified side view of a portion of a drug delivery device according to an embodiment
  • FIG. 4 schematically shows a simplified top view of the portion of a drug delivery device according to an embodiment.
  • the description of the drug delivery device as shown in the fol- lowing figures is merely illustrative. Some portions or parts of the drug delivery device are illustrated enlarged with respect to other parts. However, the dimensions of the portions and parts of the drug delivery device are for illustrational purposes only and do not represent real dimensions or ratios. Similar parts may comprise the same references.
  • the drug delivery device 100 may be configured to deliver a plurality of fixed or user- settable doses of a drug.
  • the drug delivery device 100 may be a pen-type device, preferably a pen type injector, and comprises a housing 1 , which can be formed from a single or multiple pieces.
  • ,drug means a pharmaceutical formulation containing at least one pharmaceutically active compound
  • the pharmaceutically active compound has a molecular weight up to 1500 Da and/or is a peptide, a proteine, a polysaccharide, a vaccine, a DNA, a RNA, a antibody, an enzyme, an antibody, a hormone or an oligonucleotide, or a mixture of the above-mentioned pharmaceutically active compound, wherein in a further embodiment the pharmaceutically active compound is useful for the treatment and/or prophylaxis of diabetes mellitus or complications associated with diabetes mellitus such as diabetic retinopathy, thromboembolism disorders such as deep vein or pulmonary thromboembolism, acute coronary syndrome (ACS), angina, myocardial infarction, cancer, macular degeneration, inflammation, hay fever, atherosclerosis and/or rheumatoid arthritis,
  • ACS acute coronary syndrome
  • the pharmaceutically active compound comprises at least one peptide for the treatment and/or prophylaxis of diabetes mellitus or complications associated with diabetes mellitus such as diabetic retinopathy,
  • the pharmaceutically active compound comprises at least one human insulin or a human insulin analogue or derivative, glucagon-like pep- tide (GLP-1 ) or an analogue or derivative thereof, or exedin-3 or exedin-4 or an analogue or derivative of exedin-3 or exedin-4.
  • GLP-1 glucagon-like pep- tide
  • Insulin analogues are for example Gly(A21 ), Arg(B31 ), Arg(B32) human insulin; Lys(B3), Glu(B29) human insulin; Lys(B28), Pro(B29) human insulin; Asp(B28) human insulin; human insulin, wherein proline in position B28 is replaced by Asp, Lys, Leu, VaI or Ala and wherein in position B29 Lys may be replaced by Pro; Ala(B26) human insulin; Des(B28-B30) human insulin; Des(B27) human insulin and Des(B30) human insulin.
  • Insulin derivates are for example B29-N-myhstoyl-des(B30) human insulin; B29-N- palmitoyl-des(B30) human insulin; B29-N-myhstoyl human insulin; B29-N-palmitoyl human insulin; B28-N-myhstoyl LysB28ProB29 human insulin; B28-N-palmitoyl- LysB28ProB29 human insulin; B30-N-myristoyl-ThrB29LysB30 human insulin; B30-N- palmitoyl- ThrB29LysB30 human insulin; B29-N-(N-palmitoyl-Y-glutamyl)-des(B30) human insulin; B29-N-(N-lithocholyl-Y-glutamyl)-des(B30) human insulin; B29-N-( ⁇ - carboxyheptadecanoyl)-des(B30) human insulin and B29-N-(
  • Exendin-4 for example means Exendin-4(1 -39), a peptide of the sequence H-His-Gly- Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-GIn-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe- Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2.
  • Exendin-4 derivatives are for example selected from the following list of compounds:
  • Hormones are for example hypophysis hormones or hypothalamus hormones or regu- latory active peptides and their antagonists as listed in Rote Liste, ed. 2008, Chapter 50, such as Gonadotropine (Follitropin, Lutropin, Chohongonadotropin, Menotropin), Somatropine (Somatropin), Desmopressin, Terlipressin, Gonadorelin, Triptorelin, Leu- prorelin, Buserelin, Nafarelin, Goserelin.
  • Gonadotropine Follitropin, Lutropin, Chohongonadotropin, Menotropin
  • Somatropine Somatropin
  • Desmopressin Terlipressin
  • Gonadorelin Triptorelin
  • Leu- prorelin Buserelin
  • Nafarelin Goserelin.
  • a polysaccharide is for example a glucosaminoglycane, a hyaluronic acid, a heparin, a low molecular weight heparin or an ultra low molecular weight heparin or a derivative thereof, or a sulphated, e.g. a poly-sulphated form of the above-mentioned polysaccharides, and/or a pharmaceutically acceptable salt thereof.
  • An example of a pharmaceutically acceptable salt of a poly-sulphated low molecular weight heparin is enoxa- parin sodium.
  • Pharmaceutically acceptable salts are for example acid addition salts and basic salts.
  • Acid addition salts are e.g. HCI or HBr salts.
  • Basic salts are e.g. salts having a cation selected from alkali or alkaline, e.g. Na+, or K+, or Ca2+, or an ammonium ion N+(R1 )(R2)(R3)(R4), wherein R1 to R4 independently of each other mean: hydrogen, an optionally substituted C1 -C6-alkyl group, an optionally substituted C2-C6-alkenyl group, an optionally substituted C6-C10-aryl group, or an optionally substituted C6- C10-heteroaryl group.
  • solvates are for example hydrates.
  • housing 1 comprises a proximal end 1 a and a distal end 1 b.
  • distal end of the drug delivery device 100 or a component thereof may refer to that end of the device or the component which is closest to the dispensing end of the device 100, which, for instance, comprises a needle.
  • proximal end of the drug delivery device 1 or a component thereof may refer to that end of the device or the component which is furthest away from the dispensing end of the device.
  • a needle unit 12 including a needle 13 is attached on top of the distal end 1 b.
  • the distal end 1 b of the housing 1 may serve as a cartridge holder and may be configured to contain a cartridge 11 made of a transparent material.
  • Cartridge 11 contains the drug to be delivered to a patient.
  • Cartridge 11 has a distal end covered by a membrane.
  • the membrane may be pierced by the needle to allow drug to be dispensed from the cartridge through the needle.
  • Bung 9 is retained in the cartridge. Bung 9 is movable to the distal direction with respect to the cartridge using a piston rod 8 connected thereto. Thereby a drug may be dispensed from the cartridge.
  • Piston rod 8 may be driven in the distal direction in order to move bung 9 along the distal direction with respect to the cartridge.
  • a cap 2 is used to cover the distal part 1 b of the drug delivery device, when the device is stored.
  • the proximal part 1 a of the drug delivery device comprises a window aperture 5 and markings 6 on housing 1 close to window aperture 5. Through the window, a plurality of different symbols 7, including numbers, are visible. The symbols are printed on a dose dial sleeve 20 which is in operative connection with dose dial grip 4 at the proximal end of housing 1. By rotating dose dial grip 4, dose dial sleeve 20 is rotated to select a dosage to be dispensed during operation of the drug delivery device. The a- mount of dosage to be dispensed can be seen by the corresponding dosage information 7 displayed through window aperture 5. The drug is delivered by pressing a dose button 3 after the desired dosage is selected using dose dial grip 4.
  • FIG. 2 shows dose dial sleeve 20 according to an embodiment of the present invention in greater detail.
  • a plurality of symbols 32 each of them corresponding to the amount of dosage to be delivered, is printed or molded upon the surface of dose dial sleeve 20.
  • Dose dial sleeve 20 is rotated using the dose dial grip 4 attached to dose dial slee- ve 20 at its one end 22. During rotation, symbols 32 on the dose dial sleeve are visible through window aperture 5 of housing 1.
  • window 5a is recessed with respect to the surface of the proximal end 1 a of the housing.
  • FIG. 3 shows a schematic side view of the proximal end of the drug delivery device according to an embodiment.
  • Dose dial grip 4 is in operative connection with dose dial sleeve 20, which rotationally moves around piston rod 8.
  • the symbols representing dosage information for instance a dosage to be delivered, are shown in window 5 while dose dial sleeve 20 moves along the x-direction as indicated in FIG. 3.
  • Window 5a in aperture 5 comprises a transparent and scratch-resistant material, par- ticularly plastic or glass, and is recessed with respect to the outer surface of proximal end 1 a of the housing. As a result, the outwardly-facing surface of window 5 is below the level of the surface of housing 1.
  • the recess distance between the outer surface of the housing and the surface of the window may be 10 % to 70 % of the housing's thickness.
  • the window may be recessed by up to 0,7 mm with respect to the housing.
  • the window may also protrude with respect to the inner surface of the housing, so the thickness of the window is not or only slightly reduced, thereby providing additional stability. In such cases, the recess may even be greater than 50 % of the housing's thickness.
  • window 5a is protected from scratching or grinding when the drug delivery device is moved across a surface like, for instance, a rough table.
  • FIG. 4 shows the top view of the proximal end 1 a of a drug delivery device 100 according to an embodiment.
  • Window 5a has two symmetrically arranged bulges 5b acting as additional markers. Bulges 5b together with the remaining window 5a are recessed with respect to the surface of housing 1.
  • dose dial grip 4 By rotating dose dial grip 4, the dose dial sleeve is rotated as well and different numbers corresponding to respective dosages to be delivered are shown in window aperture 5.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L’invention concerne un dispositif d'administration de médicaments qui comprend un boîtier (1) présentant une extrémité proximale (1a) et une surface extérieure. Un manchon à cadran dosimétrique (20) comprend une pluralité de symboles (7, 32) représentant des indications de dosage pendant le fonctionnement du dispositif d'administration de médicaments. Un préhenseur à cadran dosimétrique (4) est raccordé de manière fonctionnelle au manchon à cadran dosimétrique (20) pour permettre un choix posologique. Un bouton de dosage (3) est raccordé de manière fonctionnelle à une tige de piston (8) pour libérer le médicament en fonction de la dose choisie. Le dispositif d'administration de médicaments comprend une fenêtre (5a) ménagée dans le boîtier de sorte qu'au moins le symbole (7) correspondant à la dose choisie soit visible. La fenêtre (5a) ménagée dans le boîtier (1) est en retrait par rapport à la surface extérieure. La distance de retrait entre la surface extérieure du boîtier (1) et une surface de la fenêtre (5a) représente 10 à 70% l'épaisseur du boîtier (1).
PCT/EP2010/054337 2009-03-31 2010-03-31 Dispositif d'administration de médicaments muni d'une fenêtre d'indication de dose WO2010112558A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09004662.4 2009-03-31
EP09004662 2009-03-31
US16897909P 2009-04-14 2009-04-14
US61/168,979 2009-04-14

Publications (1)

Publication Number Publication Date
WO2010112558A1 true WO2010112558A1 (fr) 2010-10-07

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WO (1) WO2010112558A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013116353A1 (fr) * 2012-02-01 2013-08-08 Hernandez Caleb Système de distribution de médicament
WO2013149980A1 (fr) * 2012-04-05 2013-10-10 Sanofi-Aventis Deutschland Gmbh Injecteur de type stylo avec élément de fenêtre
JP2015512760A (ja) * 2012-04-13 2015-04-30 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ コンポーネントの適切な結合を示すインジケータを持つ自己注射装置
CN105263547A (zh) * 2013-04-10 2016-01-20 赛诺菲 用于药物传送装置的显示组件
EP3038676A1 (fr) * 2013-08-29 2016-07-06 Sanofi-Aventis Deutschland GmbH Logement et capuchon pour dispositif d'injection constitué d'un élément métallique extérieur et d'un élément plastique intérieur
US9415165B2 (en) 2009-10-16 2016-08-16 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
USD846383S1 (en) 2017-08-10 2019-04-23 Certa Dose, Inc. Carton
US10478136B2 (en) 2012-02-01 2019-11-19 Certa Dose, Inc. Radiological dosing system and method
USD938023S1 (en) 2015-09-02 2021-12-07 Certa Dose, Inc. Drug delivery syringe
CN113924136A (zh) * 2019-04-04 2022-01-11 赛诺菲 用于药物递送装置的组件
USD943737S1 (en) 2019-01-22 2022-02-15 Certa Dose, Inc. Overdose resistant drug delivery syringe
US11617835B2 (en) 2012-02-01 2023-04-04 Cd Acquisitions, Llc Apparatuses, methods, and systems for delivering measured doses of medication
US11679204B2 (en) 2018-05-17 2023-06-20 Cd Acquisitions, Llc Syringe holder for medication dosing
US11712522B2 (en) 2018-05-01 2023-08-01 CD Acquistions, LLC System and method for sequential delivery of measured doses of medication

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Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9415165B2 (en) 2009-10-16 2016-08-16 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
US10806865B2 (en) 2009-10-16 2020-10-20 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
US11819668B2 (en) 2009-10-16 2023-11-21 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
US11033690B2 (en) 2009-10-16 2021-06-15 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
WO2013116353A1 (fr) * 2012-02-01 2013-08-08 Hernandez Caleb Système de distribution de médicament
US10478136B2 (en) 2012-02-01 2019-11-19 Certa Dose, Inc. Radiological dosing system and method
US11617835B2 (en) 2012-02-01 2023-04-04 Cd Acquisitions, Llc Apparatuses, methods, and systems for delivering measured doses of medication
US11452817B2 (en) 2012-02-01 2022-09-27 Cd Acquisitions, Llc System for delivering medication
JP2015515318A (ja) * 2012-04-05 2015-05-28 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 窓要素を有するペン型注射器
AU2013245106B2 (en) * 2012-04-05 2017-07-27 Sanofi-Aventis Deutschland Gmbh Pen -type injector with window element
RU2651907C2 (ru) * 2012-04-05 2018-04-24 Санофи-Авентис Дойчланд Гмбх Шприц-ручка с оконным элементом
KR20150095557A (ko) * 2012-04-05 2015-08-21 사노피-아벤티스 도이칠란트 게엠베하 윈도우부를 구비한 펜형 주사기
US10039883B2 (en) 2012-04-05 2018-08-07 Sanofi-Aventis Deutschland Gmbh Pen-type injector with window element
CN104203313A (zh) * 2012-04-05 2014-12-10 赛诺菲-安万特德国有限公司 带有窗口元件的笔式注射器
WO2013149980A1 (fr) * 2012-04-05 2013-10-10 Sanofi-Aventis Deutschland Gmbh Injecteur de type stylo avec élément de fenêtre
KR102124660B1 (ko) 2012-04-05 2020-06-18 사노피-아벤티스 도이칠란트 게엠베하 윈도우부를 구비한 펜형 주사기
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