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WO2010013495A1 - 高度精製ボツリヌス毒素治療剤を有効成分として含有する薬学的組成物およびその利用 - Google Patents

高度精製ボツリヌス毒素治療剤を有効成分として含有する薬学的組成物およびその利用 Download PDF

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Publication number
WO2010013495A1
WO2010013495A1 PCT/JP2009/003664 JP2009003664W WO2010013495A1 WO 2010013495 A1 WO2010013495 A1 WO 2010013495A1 JP 2009003664 W JP2009003664 W JP 2009003664W WO 2010013495 A1 WO2010013495 A1 WO 2010013495A1
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therapeutic agent
highly purified
active ingredient
purified botulinum
pharmaceutical composition
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PCT/JP2009/003664
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English (en)
French (fr)
Inventor
赤池紀生
加藤啓子
原川哲博
銀永明弘
奥田祥士
大山裕介
永野礼隆
Original Assignee
財団法人化学及血清療法研究所
学校法人銀杏学園熊本保健科学大学
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Priority to JP2010522632A priority Critical patent/JPWO2010013495A1/ja
Publication of WO2010013495A1 publication Critical patent/WO2010013495A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

　中枢及び末梢神経疾患治療剤を提供するために、ＨＡ非産生性のボツリヌス菌に由来する分子量１５０ｋＤａの高度精製ボツリヌス毒素を有効成分とし、当該高度精製ボツリヌス毒素を中枢神経または末梢神経疾患患者の中枢神経または末梢神経へ直接投与することにより、神経ネットワークの主体である神経伝達物質の種類及び量を調整可能なニューロモデュレーターである中枢神経及び末梢神経疾患治療剤を用いる。
PCT/JP2009/003664 2008-07-31 2009-07-31 高度精製ボツリヌス毒素治療剤を有効成分として含有する薬学的組成物およびその利用 WO2010013495A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2010522632A JPWO2010013495A1 (ja) 2008-07-31 2009-07-31 高度精製ボツリヌス毒素治療剤を有効成分として含有する薬学的組成物およびその利用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008199069 2008-07-31
JP2008-199069 2008-07-31

Publications (1)

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WO2010013495A1 true WO2010013495A1 (ja) 2010-02-04

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WO (1) WO2010013495A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109069609A (zh) * 2015-12-11 2018-12-21 雷文斯治疗公司 使用神经递质的用于原发性情绪和情感障碍的肉毒杆菌毒素
US10960060B1 (en) 2019-10-18 2021-03-30 Penland Foundation Treatment of cardiac arrhythmia using botulinum toxin
US10960061B1 (en) 2019-10-18 2021-03-30 Penland Foundation Treatment of amyotrophic lateral sclerosis using botulinum toxin
US10967052B1 (en) 2019-10-18 2021-04-06 Penland Foundation Treatment of dyslexia using botulinum toxin
US10973873B1 (en) 2019-10-18 2021-04-13 Penland Foundation Treatment of asthma using botulinum toxin
WO2021077055A1 (en) * 2019-10-18 2021-04-22 Penland Foundation Botulinum toxin for use in treatment
US10987411B1 (en) 2019-10-18 2021-04-27 Penland Foundation Treatment of chronic obstructive pulmonary disease using botulinum toxin
US11090371B1 (en) 2019-10-18 2021-08-17 Penland Foundation Treatment of cirrhosis using botulinum toxin
US11241479B2 (en) 2019-10-18 2022-02-08 Penland Foundation Treatment methods using botulinum toxins
US11738071B2 (en) 2021-07-12 2023-08-29 Penland Foundation Treatment of acute and chronic kidney disease
US11925677B2 (en) 2021-07-12 2024-03-12 Penland Foundation Treatment of diabetes and chronic pancreatitis using botulinum toxin

Citations (5)

* Cited by examiner, † Cited by third party
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JP2004503504A (ja) * 2000-06-14 2004-02-05 アラーガン、インコーポレイテッド 運動障害の処置法
JP2005530770A (ja) * 2002-05-10 2005-10-13 アラーガン、インコーポレイテッド ボツリヌス毒素のようなクロストリジウム神経毒による、神経精神医学的障害の頭蓋内処置
JP2007509953A (ja) * 2003-10-29 2007-04-19 アラーガン、インコーポレイテッド 神経障害および神経精神障害のボツリヌス毒素処置
WO2008050866A1 (en) * 2006-10-27 2008-05-02 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Preparation containing highly purified botulinum toxin type a derived from infant botulism pathogen
JP2009132672A (ja) * 2007-10-31 2009-06-18 Okayama Univ ボツリヌス毒素由来のポリペプチドを有効成分として含む鎮痛作用を有する医薬組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004503504A (ja) * 2000-06-14 2004-02-05 アラーガン、インコーポレイテッド 運動障害の処置法
JP2005530770A (ja) * 2002-05-10 2005-10-13 アラーガン、インコーポレイテッド ボツリヌス毒素のようなクロストリジウム神経毒による、神経精神医学的障害の頭蓋内処置
JP2007509953A (ja) * 2003-10-29 2007-04-19 アラーガン、インコーポレイテッド 神経障害および神経精神障害のボツリヌス毒素処置
WO2008050866A1 (en) * 2006-10-27 2008-05-02 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Preparation containing highly purified botulinum toxin type a derived from infant botulism pathogen
JP2009132672A (ja) * 2007-10-31 2009-06-18 Okayama Univ ボツリヌス毒素由来のポリペプチドを有効成分として含む鎮痛作用を有する医薬組成物

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MITSUHIKO YOKOYAMA ET AL.: "Kairyogata Botulinus Dokuso o Mochiita Translational Research", THE NISHINIHON JOURNAL OF UROLOGY, vol. 68, no. 6, 2006, pages 234 - 238 *
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TOYOHIKO WATANABE ET AL.: "Hinyokika no Saizensen Shitteokitai Hinyokika no Atarashii Chiryo to Care no Yoten Kakatsudo Boko (OAB) ni Taisuru Chiryo no Saizensen Botulinus Dokuso Bokohekinai Chunyu Ryoho", UROLOGICAL NURSING, vol. 13, no. 7, 10 July 2008 (2008-07-10), pages 693 - 695 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109069609A (zh) * 2015-12-11 2018-12-21 雷文斯治疗公司 使用神经递质的用于原发性情绪和情感障碍的肉毒杆菌毒素
JP2019504824A (ja) * 2015-12-11 2019-02-21 ルバンス セラピュティックス インク．Ｒｅｖａｎｃｅ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 神経伝達物質の使用による原発性の気分及び感情障害のためのボツリヌス毒素
US11090371B1 (en) 2019-10-18 2021-08-17 Penland Foundation Treatment of cirrhosis using botulinum toxin
JP2022543925A (ja) * 2019-10-18 2022-10-14 ペンランド ファウンデーション 治療に使用するためのボツリヌス毒素
US10967052B1 (en) 2019-10-18 2021-04-06 Penland Foundation Treatment of dyslexia using botulinum toxin
US10973873B1 (en) 2019-10-18 2021-04-13 Penland Foundation Treatment of asthma using botulinum toxin
WO2021077055A1 (en) * 2019-10-18 2021-04-22 Penland Foundation Botulinum toxin for use in treatment
US10987411B1 (en) 2019-10-18 2021-04-27 Penland Foundation Treatment of chronic obstructive pulmonary disease using botulinum toxin
US10960060B1 (en) 2019-10-18 2021-03-30 Penland Foundation Treatment of cardiac arrhythmia using botulinum toxin
US11241479B2 (en) 2019-10-18 2022-02-08 Penland Foundation Treatment methods using botulinum toxins
US11439694B2 (en) 2019-10-18 2022-09-13 Penland Foundation Botulinum toxin for use in treatment of autism spectrum disorders
US10960061B1 (en) 2019-10-18 2021-03-30 Penland Foundation Treatment of amyotrophic lateral sclerosis using botulinum toxin
AU2020365148B2 (en) * 2019-10-18 2022-10-27 Penland Foundation Botulinum toxin for use in treatment
AU2022202689B2 (en) * 2019-10-18 2022-12-01 Penland Foundation Botulinum toxin for use in treatment
EP4045073A4 (en) * 2019-10-18 2022-12-07 Penland Foundation BOTULINUM TOXIN FOR USE IN A TREATMENT
US11883473B2 (en) 2019-10-18 2024-01-30 Penland Foundation Treatment of dyslexia using botulinum toxin
US11744881B2 (en) 2019-10-18 2023-09-05 Penland Foundation Treatment of amyotrophic lateral sclerosis using botulinum toxin
US11738071B2 (en) 2021-07-12 2023-08-29 Penland Foundation Treatment of acute and chronic kidney disease
US11925677B2 (en) 2021-07-12 2024-03-12 Penland Foundation Treatment of diabetes and chronic pancreatitis using botulinum toxin

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