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WO2010081838A2 - Récipient stérile pré-rempli - Google Patents

Récipient stérile pré-rempli Download PDF

Info

Publication number
WO2010081838A2
WO2010081838A2 PCT/EP2010/050365 EP2010050365W WO2010081838A2 WO 2010081838 A2 WO2010081838 A2 WO 2010081838A2 EP 2010050365 W EP2010050365 W EP 2010050365W WO 2010081838 A2 WO2010081838 A2 WO 2010081838A2
Authority
WO
WIPO (PCT)
Prior art keywords
tube
assembly
prefilled container
container
sterile
Prior art date
Application number
PCT/EP2010/050365
Other languages
English (en)
Other versions
WO2010081838A3 (fr
Inventor
Didier Bazile
Olivier Timbal
Juergen Sigg
Christian Schoch
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of WO2010081838A2 publication Critical patent/WO2010081838A2/fr
Publication of WO2010081838A3 publication Critical patent/WO2010081838A3/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/008—Racks for supporting syringes or needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A61M2205/585—Means for facilitating use, e.g. by people with impaired vision by visual feedback having magnification means, e.g. magnifying glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6063—Optical identification systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6063—Optical identification systems
    • A61M2205/6072—Bar codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like

Definitions

  • the present invention generally relates to an assembly for encasing a sterile prefilled container and methods for encasing a sterile-prefilled container.
  • Prefilled containers such as syringes, although filled under aseptic conditions, are not packed into their secondary packaging containers — such as pouches, boxes or blister packs — in an aseptic environment, and are therefore likely to be microbiologically contaminated on their external surfaces.
  • Terminal sterilization of prefilled containers in secondary packaging is one way to provide these containers to an end user with a low exterior bio-burden and low risk of contaminants, for safe application of the product by the end user. If, however, the drug product in the container is sensitive to the action of classical sterilization methods, like heat, gases or radiation, a terminal sterilization cannot be performed. Such is the case with prefilled containers housing sensitive biomolecules; the container, to remain sterile, must be protected from direct contact with the environment in the absence of application of terminal sterilization.
  • Blister packs and pouches are currently used to this end, but cannot be adapted to an aseptic environment without great difficulty.
  • the blister packaging process can create a significant amount of particles which would contaminate a pharmaceutical filling line.
  • Those particles present problems for downstream applications with the drug product and problems to the end user.
  • the necessity to inject drugs intravitreally has significantly increased.
  • Sterility is absolutely critical for this type of injection. An introduction of germs inside the eye as a consequence of an injection can result in a severe infection leading to blindness. Whereas it is possible to withdraw a drug solution for injection from a vial that is not sterile on the vial exterior surface for placement into a completely sterile syringe, the case is quite different with a prefilled syringe. The contents of a prefilled syringe are not transferred to a separate device, therefore the prefilled syringe must be sterile on the outside surface if it is to be used in applications such as intravitreal injection, or in any environments where sterility is of great concern, such as in a surgical suite.
  • Described herein is an assembly for encasing a sterile-prefilled container and methods for encasing a sterile-prefilled container.
  • the assembly ensures surface sterility of the sterile-prefilled container by encasing the prefilled container in a hermetically-sealed tube.
  • the exemplary assembly and methods described herein provide a prefilled container, with sterile exterior surfaces, to an end user, even in the absence of terminal sterilization. This is particularly beneficial when the drug product contained in the prefilled container is otherwise sensitive to classical means of terminal sterilization, such as by exposure to moist or dry heat, gas or radiation.
  • the adaptation of traditional pharmaceutical packaging to an aseptic environment has not previously been feasible due to persistent problems, such as requirements for sterility, excessive particle generation and subsequent contamination, and the prohibitive size of equipment needed to be placed in isolation, for example, Grade A according to EC Guide to Good Manufacturing Practices.
  • a tube or other housing/material encasing and sealing a sterile-prefilled container with sterile surfaces can be prepared via the process described herein, employing aseptic methods in isolation, or with a combination of aseptic and classical sterilization methods, and most significantly, at a point in the pharmaceutical packaging stream at the core of the pharmaceutical filling line.
  • the entire method can be performed manually, if necessary. In another embodiment, a portion of, or the entire method, is automated or under the control of an automated system. In one embodiment, the container is pre-sterilized, and is aseptically filled with a therapeutic agent, such as a drug solution, in isolation.
  • a therapeutic agent such as a drug solution
  • the prefilled container prior to transfer from the sterile environment of isolation, is packed into a previously sterilized pre-formed housing material, such as a tube, and hermetically sealed. Encasing the pre-sterilized container filled with sterile contents — while the prefilled container and tube remain in the aseptic manufacturing environment, such as isolation — ensures that the entire contents of the tube remains sterile.
  • the tube may include a transparent portion, which allows visual inspection of the prefilled container upon departure of the assembly from the filling line, a feature that is not possible if the prefilled container is packaged in traditional packaging, such as an opaque pouch or a blister pack.
  • the process described herein provides means of manipulating the prefilled container without compromising its sterility, i.e. during visual control, labeling, packaging, etc.
  • the process described herein also guarantees that an end user, such as a surgeon, is provided a container with sterile surfaces that can be introduced into an environment, such as a surgical suite, without further precautions or risk of contamination.
  • labeling of the assembly can include information required by health authorities to be placed on the prefilled container packaging.
  • labeling can be accomplished by the use of pre-printed containers or imprinting of data to containers, followed by cleaning of container, siliconization if necessary and sterilization of the labeled container prior to filling.
  • the assembly presented herein is adaptable to all drug products and containers or devices having requirements or desirability for sterility at their end use.
  • Fig. 1 shows a front view of an exemplary assembly for encasing a sterile prefilled container.
  • Fig. 2 shows a side view of the exemplary assembly encasing a sterile prefrent container shown in Fig. 1.
  • Figs. 3-11 show several exemplary devices used in concert with each other as part of a process to hold, transfer, and secure prefilled containers and portions of the exemplary assembly during the process.
  • the assembly described herein provides a rigid pre-formed material, such as a tube, encasing a sterile prefilled container, ideally suited for use in intravitreal injections.
  • the assembly thereby, eliminates the need for withdrawals from separate vials of drug solution, thus simplifying intravitreal administration and reduces the risks of contamination or eye infection. Furthermore, the process described herein preserves sterility of prefilled containers, assembled in isolation, especially those that cannot be subjected to additional terminal sterilization steps.
  • the assembly and method described herein permits a sterile-prefilled container to be manipulated, labeled, and/or packaged, without compromising sterility of the container, its surfaces, and/or its contents.
  • Aseptic conditions refer to conditions free of bacterial or microbial contamination as they are defined, for example, in the PIC Guide to Good Manufacturing Practice of Medicinal Products, Sterile Annex (Aug. 2006).
  • administering refers to the method of administering treatment to a subject or patient in need thereof, such as parenteral administration, intravenous administration and intravitreal administration.
  • Container is meant to include syringes, tubes, vials, bags, bottles, or other pre-formed containers or other means useful for housing a therapeutic agent, such as a drug product.
  • Containers may be fabricated using standard methods or may be containers as available and provided from known manufactures or suppliers. They may be manufactured from transparent, semi-transparent or opaque plastic materials, glass, metal or other suitable materials.
  • Prefilled container refers to a container as described above that is filled with a drug product, whether in solid or liquid form, or other biological agents, such as peptides, proteins or recombinant biologicals, whether in solid or liquid form, under aseptic conditions.
  • Device refers to a device used, in part, for administering medical treatment and whose production or sale may, in part, be required to comply with requirements, such as safety requirements, set forth by a government agency, such as the Food and Drug Administration.
  • Encased refers to material, such as a tube, encasing or housing a prefilled container, and is meant to include tubes, cylinders, bags, bottles, vials, or other suitable materials capable of housing a prefilled container.
  • Filling line refers to the filling line in pharmaceutical production and packaging, such as by an automated process designed to fill and seal a container, such as by placing stopper in the container or aluminum crimp cap or by closing the container by other mean, such as with heat, under aseptic conditions.
  • An "instruction” or “instructional material” includes a publication, a recording, a diagram or any other medium of expression which can be used to communicate the usefulness of the assembly and/or method of the invention for its designated use.
  • the instruction or instruction material may be presented together as part of the assembly and/or process or provided independently/separately of the assembly and/or process to an end user.
  • Isolation and/or “Isolator”, as used herein, refer to practices in pharmaceutical production, filling and packaging, wherein a clean, or sterile environment, is separated from a non-sterile environment to limit or prevent the introduction or spread or contamination of infectious agents, such as microorganisms.
  • Solution refers to the contents of a prefilied container and includes solutions of biological therapeutics and drug products, protein products, peptide products, biological products, imaging solutions and aqueous solutions. Solutions include those that are temperature, oxidation or radiation sensitive due to the molecular make-up of the solution.
  • SAL sterility assurance level
  • Fig. 1 shows a front view of an exemplary assembly 100 comprising a tube 104 for encasing a sterile-prefilled container 102.
  • tube 104 acts as housing for encasing the container 102.
  • Tube 104 can be configured to include sections, such as a top portion and a bottom portion of the tube such that the sections, or portions, are separable and joinable from each other.
  • the tube 104 has a length and width generally larger than the height and width of container 102.
  • tube 104 can be over varying sizes which depend, in part, on the size, shape or volume of the prefilied container encased therein.
  • container 102 is held securely in place within tube 104 by a securing mechanism 108, such as a flange, that engages when tube 104 is closed or sealed.
  • tube 104 is capable of being sealed and/or unsealed via a sealing mechanism 106, such as a cap, snap, lid or screw.
  • a sealing mechanism 106 such as a cap, snap, lid or screw.
  • a portion of tube 104 is transparent.
  • tube 104 is configured with a transparent portion, such as a window 110.
  • window 110 is configured where a portion of the tube 104 varies in thickness, providing greater transparency.
  • window 110 is configured as a magnifying portion to permit visual examination of the tube 104 interior, including the prefilled container 102 and its contents.
  • an optional identification label 112 such as an adhesive, can be adhered or otherwise fixed to tube 104.
  • identification label 112 contains information regarding the assembly 100, such as information allowing the device 100 to be tracked along a manufacturing and distribution chain.
  • the label 112 is in the form of a scannable bar-code that holds identifying information.
  • identifying information could be information regarding the assembly and/or the drug product contained therein, such as administration guidelines, safety information, storage information and the like.
  • the prefilled container 102 comprises a syringe of appropriate volume suitable for the drug product contained therein.
  • the syringe is sterilized prior to filling with drug product under aseptic conditions.
  • a suitable syringe can include multiple parts, such as a syringe body, a piston, a plunger, a seal, a shaft, a luer or needle shield.
  • the syringe can include a needle and /or needle cap.
  • the syringe and syringe components may be fabricated via any known process in the art, such as injection molding or conventional glass processing and with any material suitable for use as syringe components, or any syringe available from medical supply manufacturers or suppliers as known by those skilled in the art.
  • syringe components are sterilized in a clean room environment. P re-sterilized syringes are then suitable for filing with desired solution or drug product.
  • the syringe is filled with solution under aseptic conditions, whether by an automated or manual process. Thus, the contents of the syringe are sterile.
  • filled is meant to refer to the placement of contents, such as solution, into the syringe in an appropriate amount, such as an appropriate volume or appropriate concentration.
  • an appropriate amount, volume or concentration will vary depending on the nature of the contents and their intended use.
  • the prefilled container is filled with a drug product, such as in the form of liquid, solution, powder or solid.
  • the drug product is a solution, such as a drug solution or protein solution, which is otherwise sensitive to standard sterilization methods, such as exposure to high temperatures or exposure to radiation, in another embodiment, the drug product is one that has been lyophilized, in other words a solid, and requires constitution in liquid or solution prior to use.
  • a drug product is any drug product having requirements or desirability for sterility of the drug product container surface.
  • the drug product is a protein solution, such as ranibizumab (e.g. 6mg/ml or 10 mg/ml) solution for intravitreal injection.
  • the tube 104 is of suitable size and of any suitable material for encasing or housing a prefilled container, such as a prefilled syringe.
  • a portion of the tube is transparent.
  • the transparent portion of the tube is configured as a window into the tube interior, such as shown and described above in Fig. 1.
  • a portion of the tube window is configured in such a way as to act as a magnifying glass, thereby allowing closer visual inspection of the tube contents.
  • the tube is configured to hold a single prefilled container securely in a pre-defined position.
  • the tube is configured with a sealing mechanism.
  • Suitable sealing mechanisms include lids, caps, screws, stoppers, snaps or seals, or other mechanisms capable of hermetically sealing the tube and allowing the tube to be unsealed when desired for withdrawal of the prefilled container.
  • the sealing mechanism is reversible, such that at appropriate time of end use the encapsulated material, such as the prefilled container, may be released and presented to an end user.
  • Sealing mechanisms can be comprised of like material as the tube or of another material, such as a rubber materials or plastics of differing flexibility.
  • suitable sealing mechanisms include those capable of sealing the contents of the tube tightly, such as sealing performed under vacuum. Suitable sealing mechanisms must prevent contamination ingressing through the tube during transport or storage once the encased prefilled syringe has left the sterile environment of isolation.
  • the tube is comprised of a transparent, optically neutral polymer, such as polycarbonate, polystyrene, PET, cyclo-olefin polymer or cyclo-olefin copolymer.
  • a transparent, optically neutral polymer such as polycarbonate, polystyrene, PET, cyclo-olefin polymer or cyclo-olefin copolymer.
  • Suitable tubes can be fabricated under suitable conditions known in the art, such as by injection molding, injection blow molding, or other technologies.
  • the tube is manufactured from non-plastic material, like glass or metal.
  • Tubes or other suitable rigid pre-formed housing may also be provided by recognized manufacturers and suppliers as known in the art.
  • the tube is sterilized by any suitable sterilization method, such as exposure to moist or dry heat or radiation sterilization, prior to receiving the prefilled container for housing within the tube once the encapsulant and prefilled container are in isolation.
  • previously sterilized syringes are filled with a formulation as described in U.S. Patent No. 7,060,269 under aseptic conditions in isolation following filtration through a sterilization-grade syringe filter (e.g. with a pore size of 0.2 ⁇ m), and prefilled syringes are then encased within tube and hermetically sealed, whether by an automated or manual process.
  • a sterilization-grade syringe filter e.g. with a pore size of 0.2 ⁇ m
  • Exemplary method encasing a sterile prefilled container Figs. 3-11 show several exemplary devices used in concert with each other as part of a process to hold, transfer, and secure prefilled containers and portions of assembly 100 throughout the process. This exemplary process may be performed in an isolator (not shown), or in a clean room in aseptic conditions.
  • Fig. 3 shows an exemplary tray 302 with exemplary plastic caps 304. Tray 302 rotates about a horizontal axis point 306 (i.e., 180 degrees or 360 degrees, etc.).
  • Fig. 4 shows an exemplary tray 402 holding prefilled containers 102. Specifically, containers 102 are resting within portions 404 of tray 402.
  • Fig. 5 shows tray 302 rotated about axis point 306 with caps 304 aligned for engagement with prefilled containers 102, which are held by tray 402.
  • Fig. 6 shows tray 302 rotated back to its original position, with tray 402 flipped about horizontal axis 306; so, contents of tray 402 are now transferred into caps 304.
  • Fig. 7 shows tray 402 removed from engagement with tray 302.
  • Fig. 8 shows tray 802 holding a portion of tube 104.
  • Fig. 9 shows tray 802 flipped over tray 302 in a position so that portions of tubes 104 can engage caps 304 held in position by tray 302.
  • Fig. 10 shows portions of tubes 104 fully engaged with caps 304 forming a fully encased-prefilled container 102.
  • Fig. 11 shows assemblies 100 (fully encased-prefilled containers 102) in their upright position upon completion of the process shown in Figures 3-11.
  • one tray e.g. 302 in Fig. 3 holds a portion of the previously sterilized tubes, for example securing mechanism portions such as caps for securing the tubes sealed once the caps are in engagement with the other portion of the tube.
  • a second tray (e.g., 402 in Fig. 4) holds containers prefilled with drug solution under aseptic conditions.
  • the second tray is a tray similar to those used for filling of ready-to-fill syringes, such as sold by Beckton-Dickinson under the name SCF, by Gerresheimer under the name RTF or by Nuova Ompi under the name EZ-FiII, and the like.
  • the first tray and second tray are positioned vertically on top of each other, such that the prefilled containers become mounted within the caps held by the opposite tray.
  • the prefilled containers become positioned inside the portion of the tube making up the caps, they are released from the tray formerly holding the prefilled containers, by placing the so assembled trays upside down and pulling off the syringe tray (referred to as a "nest").
  • a third tray (e.g. 802 of Fig. 8) holding the other portion of the tube is then engaged vertically over the prefilled containers mounted within the tube caps.
  • the two portions of the tube essentially the bottom half of the tube and the top half (cap) of the tube, are engaged together and are sealed, such as by snapping the portions of the tube together, so that the tube is securely sealed off to the outside environment.
  • the outside of the tube housing the sterile prefilled container can be labeled, such as with a tracking label, identification label or any other identifying information that may be necessary or useful to convey on the exterior surface of the tube.
  • the assembled tube encasing the sterile prefilled container is then transported for further packaging or processing outside of the isolator. As the top and bottom part of the tubes are snapped into the trays they now can easily be removed from the trays and can be processed individually.
  • the trays are designed such that their outside dimensions are compatible with commercially available syringe trays and they are hermetically closed by using a sealed-on foil, such as Tyvek. They can then be passed through a commercial syringe filling line (similarly to those trays containing empty syringes), including equipment for outside sterilization of the syringe trays when entering the aseptic filing environment or isolator. While the syringe filling line is adjusted to fill only the syringe trays, the trays with the tubes and caps are just passed through the filling station without processing. In the space after the filling station, the trays can be assembled, either manually or automatically, to enclose the syringes into the trays in a very economical fashion.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un ensemble permettant d'enrober un récipient stérile pré-rempli et des procédés de préparation associés. L'ensemble convient idéalement pour une utilisation finale impliquant une injection intravitréenne. Les procédés décrits ici concernent un récipient pré-rempli présentant des surfaces extérieures stériles destiné à un utilisateur, même en l'absence de stérilisation terminale. Ceci est particulièrement bénéfique lorsque le médicament dans le récipient pré-rempli est par ailleurs sensible aux moyens classiques de stérilisation terminale.
PCT/EP2010/050365 2009-01-14 2010-01-13 Récipient stérile pré-rempli WO2010081838A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09150572 2009-01-14
EP09150572.7 2009-01-14

Publications (2)

Publication Number Publication Date
WO2010081838A2 true WO2010081838A2 (fr) 2010-07-22
WO2010081838A3 WO2010081838A3 (fr) 2010-09-23

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JP5081330B1 (ja) * 2012-06-20 2012-11-28 株式会社アルテ 注射器製造用カートリッジセット及び二室式容器兼用注射器の製造方法
US8377000B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Enteral feeding apparatus having a feeding set
US8377001B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Feeding set for a peristaltic pump system
US8689439B2 (en) 2010-08-06 2014-04-08 Abbott Laboratories Method for forming a tube for use with a pump delivery system
EP2939649A4 (fr) * 2012-12-27 2016-07-20 Terumo Corp Cylindre extérieur de seringue pré-remplie et son conditionnement
JP2019058679A (ja) * 2012-06-01 2019-04-18 ノバルティス アーゲー 注射器
USD1035436S1 (en) 2022-08-26 2024-07-16 Regeneron Pharmaceuticals, Inc. Packaging
USD1042107S1 (en) 2022-08-26 2024-09-17 Regeneron Pharmaceuticals, Inc. Packaging
USD1047700S1 (en) 2022-08-26 2024-10-22 Regeneron Pharmaceuticals, Inc. Packaging

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Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8689439B2 (en) 2010-08-06 2014-04-08 Abbott Laboratories Method for forming a tube for use with a pump delivery system
US8377000B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Enteral feeding apparatus having a feeding set
US8377001B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Feeding set for a peristaltic pump system
JP7042954B2 (ja) 2012-06-01 2022-03-28 ノバルティス アーゲー 注射器
JP2021180916A (ja) * 2012-06-01 2021-11-25 ノバルティス アーゲー 注射器
US12048837B2 (en) 2012-06-01 2024-07-30 Novartis Ag Syringe
JP2019058679A (ja) * 2012-06-01 2019-04-18 ノバルティス アーゲー 注射器
JP2021184827A (ja) * 2012-06-01 2021-12-09 ノバルティス アーゲー 注射器
US11103644B2 (en) 2012-06-01 2021-08-31 Novartis Ag Syringe
US11110226B2 (en) 2012-06-01 2021-09-07 Novartis Ag Syringe
US11147925B2 (en) 2012-06-01 2021-10-19 Novartis Ag Syringe
US11179521B2 (en) 2012-06-01 2021-11-23 Novartis Ag Syringe
US11185635B2 (en) 2012-06-01 2021-11-30 Novartis Ag Syringe
JP5081330B1 (ja) * 2012-06-20 2012-11-28 株式会社アルテ 注射器製造用カートリッジセット及び二室式容器兼用注射器の製造方法
US9919094B2 (en) 2012-06-20 2018-03-20 Arte Corporation Cartridge set for manufacturing syringe and method for manufacturing dual-chamber type combined container-syringe
EP2939649A4 (fr) * 2012-12-27 2016-07-20 Terumo Corp Cylindre extérieur de seringue pré-remplie et son conditionnement
US10279103B2 (en) 2012-12-27 2019-05-07 Terumo Kabushiki Kaisha Outer cylinder for prefilled syringe and outer cylinder packaging for prefilled syringes
USD1035436S1 (en) 2022-08-26 2024-07-16 Regeneron Pharmaceuticals, Inc. Packaging
USD1042107S1 (en) 2022-08-26 2024-09-17 Regeneron Pharmaceuticals, Inc. Packaging
USD1047700S1 (en) 2022-08-26 2024-10-22 Regeneron Pharmaceuticals, Inc. Packaging

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