WO2010078932A2

WO2010078932A2 - Diols as antiperspirant agents

Info

Publication number: WO2010078932A2
Application number: PCT/EP2009/009105
Authority: WO
Inventors: Stefan Biel; Heike Miertsch; Katja MÄTZOLD; Maren Meyer; Katrin Weinert
Original assignee: Beiersdorf Ag
Priority date: 2009-01-07
Filing date: 2009-12-18
Publication date: 2010-07-15
Also published as: WO2010078932A3; EP2385818B1; EP2385818A2; DE102009004269A1

Abstract

the invention relates to the use of diols as antiperspirant agents in cosmetic preparations.

Description

Diols as antiperspirant agents

The invention relates to diols as antiperspirant active agents and their use in cosmetic or dermatological preparations.

Cosmetic formulations for use as underarm products contain antiperspirant and / or deodorant agents.

The desodorienden agents serve as protection against unpleasant odors from sweating. Various principles of action may underlie the deodorizing agents. Conceivable operating principles are the covering of perspiration, e.g. with perfume or the absorption of the odor by e.g. 1, 5-pentanediol (WO 2007/063065 A1). Since the smell of sweat caused by the decomposition of human bodily excretions by bacteria, germ-inhibiting, antimicrobial agents and enzyme inhibitors are also referred to as desodoriende agents and used in cosmetic preparations (Domsch, A., The cosmetic preparations, 1990, Volume II, 4th Edition, Verlag Industrie, H. Ziolkowsky KG, Augsburg; Limbach, W., Kosmetik, 1995, 2nd extended edition, George Thieme Verlag, Stuttgart, New York).

Antiperspirants are substances that hinder the appearance of sweat on the surface. This can be achieved by closing the sweat gland duct, e.g. done by film-forming or astringent agents. Furthermore, substances which influence the activity of the eccrine sweat gland are also used as antiperspirant active substances. (Domsch, A., The cosmetic preparations, 1990, volume II, 4th edition, publishing house for former industry, H. Ziolkowsky KG, Augsburg; Limbach, W., cosmetics, 1995, 2. extended edition, George Thieme publishing house, Stuttgart, New York).

It is therefore clear to distinguish between deodorant and antiperspirant acting.

The combination of astringents with antimicrobial substances in the same composition is also common.

Almost all cosmetic antiperspirants today contain astringents - predominantly aluminum salt, such as aluminum hydroxychloride (aluminum chlorohydrate, ACH or activated ACH-AACH) or aluminum-zirconium salt (AZG), as an antiperspirant active. Although these aluminum salts based AT agents reduce the sweat emitted by the body, but as an unwanted side effect to skin irritation and to white residues on the skin or clothing after drying or in long-term use to deposits in clothing. In addition, the low pH (<5) and the electrolyte properties of the aluminum salts used as antiperspirant lead to limitations in the preparation of cosmetic formulations for application to the skin, both in terms of choice of raw materials (acid compatibility, no strong bases, as these precipitate AI (OH) ₃ lead) as well as in terms of storage stability.

It would therefore be desirable to provide an antiperspirant which does not demonstrate the aforementioned disadvantages and side effects.

It would also be desirable to provide an antiperspirant preparation which enriches the state of the art and represents an alternative to the known preparations.

In particular, it is desirable to provide a cosmetic and / or dermatological antiperspirant formulation having an antiperspirant effect without the disadvantages of aluminum-containing preparations.

In particular, it is desirable to provide such a preparation which contributes to the stabilization and / or maintenance of the antiperspirant activity of an antiperspirant after sweating and / or skin cleansing.

It would also be desirable to have an antiperspirant that, in contrast to ACH-containing systems, in addition to the antiperspirant effect skin hydration of the axis skin allows, as ACH-containing preparations often cause dehydration and associated additional irritation of the skin.

In particular, it is also desirable to provide an antiperspirant active which allows for the widest possible possibilities of galenic incorporation into cosmetically acceptable and attractive formulary systems.

It is known that glycols are used as formula components in cosmetic preparations and also in combination with ACH, as for example in EP 1206 239 B1, US 7235229 B2, US 2007/0202062 or EP 1 206 237 B1.

In EP 1478 231 B1 and DE 199 24 496 A1, longer-chain diols (C5-C10) are described as antimicrobial, ie, desodoriing substances and their use as deodorant and preservative aid. Furthermore, diols are used as odor reducers and absorbers in sanitary articles and sprays (WO 2007/063065).

AT 345467 and US 4617185 disclose organic compounds selected from aliphatic compounds having from 2 to 10 carbon atoms or from 2 to 3 carbon atoms and having at least 2 hydroxyl groups with odor-suppressing properties. DE 3248093 discloses the deodorizing properties of propylene glycol.

An antiperspirant, antiperspirant effect of the diols is not found in the prior art. On the contrary, their combination is disclosed as being preferred only with antiperspirants (antiperspirants).

It is known from parallel applications of the applicant, the antiperspirant efficacy of short-chain vicinal diols, glycols, such as 1, 2-propylene glycol.

Aluminum hydroxychloride-propylene glycol complex are also known AT agents, such as i.a. in US 6251 412 B1 and US Pat. No. 6,783,027 B2.

This complex is a coordination complex of ACH and propylene glycol in the water, which is usually coordinated to the metal, displaced by propylene glycol and replaced. The proportion of ACH in these complexes is significantly greater than that of propylene glycol.

EP 1604642 A1 discloses the use of C3-C6-alkane polyols having at least 3 hydroxyl groups in antiperspirants.

From all this information of the prior art, however, the way to the present invention was not shown. Surprisingly, it has now been found that diols of the structure

R2

where the radicals R are selected

R 2, R 3 and R 4 = OH, CH 2 --OH, CH 3, CHOH - CH 3, CH 2 -CHOH-CH 3, C 2 H 4 -OH, C 2 H 5, H, where there are two OH groups in the molecule, the maximum C number of all radicals R 2, R3 and R4 is not greater than 6 and excluding aliphatic vicinal diols having a C atom number of 2 to 6 have an antiperspirant and / or antiperspirant effect.

The invention therefore comprises cosmetic or dermatological preparations comprising one or more antiperspirant (AT) substances of this structure.

Preferred AT agents are 1, 3-propylene glycol, 1, 3-butylene glycol, 2,4-pentylene glycol, 2,5-hexanediol.

For example, at 1, 3 propylene glycol are R1 = H, R2 = OH, R3 = H and R4 = OH, in 2.5 - hexanediol are R1 = CH3, R2 = OH, R3 = H, R4 = CH2-CHOH-CH3.

Also aromatic diols of the structure

have an antiperspirant effect.

In the above structures are

R1 = phenyl,

R2 = OH

R3 = H

R4 = CH2 - OH or

R1 = phenyl, R2 = OH R3 = OH R4 = CH3.

The diols according to the invention have, according to the name, at least and at most only two hydroxyl groups. A chain length of more than 6 C atoms in aliphatic diols is likewise not preferred.

In the case of aromatic diols, the radicals R2, R3 and R4 in the sum are likewise limited to chains up to C6, advantageously to chain lengths of up to C4, in particular C3.

According to the invention, aliphatic vicinal diols having C 2 to C 6, in particular monoethylene glycol, diethylene glycol, propylene glycol (propane-1,2-diol), butylene glycol (1, 2 Butylene glycol) and the corresponding 1, 2 - diols such as pentanediol or hexanediol, except.

The surprising antiperspirant efficacy was studied in studies of the AT mechanism of action of aromatic diols in aqueous systems, various oils, and O / W emulsions (see Figure 1). The figures show the amount of residual weld compared to the untreated area after product application. 100% residual welding amount corresponds to 0% sweat reduction. The sweat reduction was based on M. Keskin et al. J. Invest. Dermatol. 1998; 110: 591 measured. In the measurements, the test substances are applied to the forearm of the subjects. The subjects are stimulated to sweat at 75 ⁰ C; After the start of the sweat production, the number of sweat-releasing sweat glands in the test area is determined by means of silicone impression technology and compared with an untreated comparison area.

Surprisingly, it was found in these studies that the non-vicinal diols of the structure according to the invention, such as in particular 1, 3-propylene glycol, 1, 3-butylene glycol, 2,4-pentylene glycol and / or 2,5-hexanediol have antiperspirant or antiperspirant effect.

This is all the more surprising that the AT performance of a preparation comprising 1, 3 propylene glycol, advantageously up to 50% wt. Dispersed in water based on the total mass of the preparation, has a good AT performance, compared to a preparation comprising 10 % By weight aluminum chlorohydrate (see Figure 1).

Figure 1 shows the amount of residual sweat compared to the untreated area after product application compared to the known AT active substances aluminum chlorohydrate and vicinal glycols in water. The antiperspirant effect of the diols according to the invention is approximately comparable to the vicinal diols, 1,2-propylene glycol and 2,3-butylene glycol, as described in the copending applications.

That is, the inventive use of the diols according to the invention allows an equivalent or slightly worse antiperspirant effect than known and proven preparation with antiperspirant active ingredient such as ACH. In all the figures one can see very clearly that without previously known antiperspirant active substances, such as ACH, nevertheless an antiperspirant effect can only be observed on account of the diols.

It is preferred to use the diols according to the invention in combination with the antiperspirant vicinal diols together in cosmetic preparations.

The diols penetrate very well through the stratum corneum and the epidermis. They are able to build up an osmotic pressure that influences the mechanism of sweat secretion. The absorption of water along the sweat gland duct is also affected by the preparations of the invention and the diols. Furthermore, the diols are converted by the enzyme alcohol dehydrogenase in the skin. The resulting reaction products can alter the membrane structures, causing altered ion permeability, which in turn can affect sweat secretion.

It is advantageous that in inventive cosmetic preparations comprising diols according to the invention, especially 1, 3-propylene glycol, 1, 3-butylene glycol, 2,4-pentylene glycol and / or 2,5-hexanediol, entirely on other antiperspirant active ingredients such as aluminum salts, e.g. ACH, can be waived and yet a sufficient antiperspirant protection is guaranteed.

This also leads to the elimination of the disadvantages listed, such as skin irritation and Hautbzw. Clothing discolorations (white), as these are mainly due to the presence of ACH.

Therefore, in addition to the diols, cosmetic preparations according to the invention preferably comprise no further astringent or antiperspirant active substances, in particular no aluminum salts, in particular no ACH and / or AACH (activated aluminum chlorohydrate).

It is known that preparations with Al salts cause a relatively permanent blockage of the welding pores and therefore can also have an AT activity over several hours or days. This means that even on the day after the application, there may still be an effect. However, it is disadvantageous, as explained, that skin irritations may occur. The diols, in particular 1, 3-propylene glycol, 1, 3-butylene glycol, 2,4-pentylene glycol and / or 2,5-hexanediol, show, astonishingly, an immediate AT effect (immediate effect), which can be measured already after the first application is and does not need to be built by multiple application. However, this without the skin irritation promoting depot effect of aluminum salts.

An essential advantage of the preparations according to the invention is, moreover, that there is no discoloration on the skin or clothing compared with the AT agents based on aluminum salts. The so-called white is omitted as well as the after repeated wearing and washing in lying directly on the armpit skin to be observed residues.

A combination of the diols with perspiration-reducing agents, which are not based on an astringent mechanism of action, is advantageous. Preference is given to AT agents from the groups of anticholinergics, such as, for example, 4 - [(2-cyclopentyl-2-hydroxyphenylacetyl) oxy] -1, 1-dimethylpiperidinium salts, especially 4 - [(2-cyclopentyl-2-hydroxyphenylacetyl) oxy] -1, 1 -dimethyl-piperidinium bromide (glycopiperolate), in particular, these may contain to a proportion of preferably 0.05 to 1, 0 wt.%, Preferably 0.1% - 0.7%, in particular 0.3% - 0.5 wt.%, Based on the total mass of the preparation may be added. An enhancement of the antiperspirant effect is thus achievable.

Likewise preferred is the combination with antimicrobial agents, in particular with polyaminopropylene biguanide and combinations of known deodorizing and / or antimicrobial agents

The antiperspirant effect is the possibility of reducing or preventing perspiration. That Inventive diols, in particular 1, 3-propylene glycol, 1, 3-butylene glycol, 2,4-pentylene glycol and / or 2,5-hexanediol act as a sweat inhibitor, so reduce or prevent the formation of perspiration.

The preparations according to the invention reduce the sweat flow (measured in accordance with GE Pierard et al., Skin Pharmacol Appl Skin Physiol 2003; 16: 324-342 and M. Keskin et al., J. Invest Dermatol., 1998; 110: 591) in low concentrations in preparations analogous to the example formulations. Even after heavy sweating or body cleansing, a somewhat reduced sweat flow reduction can still be observed without the product being applied again beforehand.

Although the diols according to the invention are known chemical substances. However, they are not named in cosmetic preparations and especially as antiperspirant active substances. A use in AT or deodorants as AT active substance is likewise not known.

Advantageously, preparations according to the invention may additionally be added with deodorants.

All active substances commonly used for deodorants can advantageously also be used, for example odor maskers such as the common perfume ingredients, odor absorbers, for example the layer silicates described in DE 40 09 347, of these in particular montmorillonite, kaolinite, mit, beidellite, nontronite, saponite, hectorite, bentonite, Smectite, for example, zinc salts of ricinoleic acid. Germ-inhibiting agents are also suitable for incorporation into the preparations according to the invention. Advantageous substances are, for example, 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Irganan), 1,6-di- (4-chlorophenylbiguanido) hexane (chlorhexidine), 3,4,4'-trichlorocarbanilide, quaternary ammonium compounds, clove oil, mint oil, thyme oil, triethyl citrate, farnesol (3,7,11-trimethyl-2,6,10-dodecatriene-1-ol) as well as those described in DE 37 40 186, DE 39 38 140, DE 42 04 321, DE 42 29 707, DE 42 29 737, DE 42 37 081, DE 43 09 372, DE 43 24 219 described effective agents. Also, sodium bicarbonate is advantageous to use. As deodorizing agents, small amounts of astringents, e.g. Alums are used. The germ-inhibiting effect of small amounts of astringent substances has already been described in patent EP 96 02108. It is advantageous concentration between 1% and 8%.

The cosmetic and dermatological preparations according to the invention may comprise cosmetic adjuvants conventionally used in such preparations, for example preservatives, bactericides, UV filters, antioxidants, water-soluble vitamins, minerals, suspended solid particles, perfumes, substances for preventing foaming, dyes, pigments which have a coloring effect, thickening agents, moisturizing and / or moisturizing substances or other usual Components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers or silicone derivatives.

Preferably, the combination with detergents, e.g. Preservatives, ethanol or perfume compositions, which lead to an increase in the antiperspirant activity of the diols.

Likewise, the addition of penetration-promoting substances, such as ethanol, for the preparation according to the invention is preferred. The use concentration of ethanol is between 0 and 50% by weight, preferably between 10 and 50% by weight, based on the total mass of the preparation. An increasing influence of the penetration-promoting substance, such as ethanol, on the AT activity of the diols was found.

The cosmetic preparation according to the invention is advantageously characterized in that it is in the form of an aqueous or aqueous-alcoholic solution, an emulsion (W / O, O / W, W / Si, Si / W or multiple emulsion, macro-, micro- or nanoemulsion ), a dispersion, a Pickering emulsion, a gel, a hydrodispersion gel or an anhydrous preparation.

According to the invention, the preparation may also be present in the form of a low-viscosity, sprayable aqueous or aqueous-alcoholic solution, in the form of a gel, in a wax matrix, a stick form, as an ointment, cream or lotion (possibly sprayable). According to the invention, the preparation can advantageously also be used as an aerosol, spray or as a soaking medium for a plaster or cloth. Therefore, plasters and wipes are impregnated with the preparation according to the invention, according to the invention. As a cosmetic preparation, the diols according to the invention are preferably formulated as gel, stick, aerosol and / or as emulsion. As a gel, the advantage is generated that gel formers can be used, which otherwise can not be used in combination with ACH. As a pen or aerosol, there is the advantage of avoiding white residue on skin and clothing. Formulated as an emulsion, the preparation according to the invention offers a better skin feel to ACH-containing formulations and allows better skin moisturization.

For application of the preparation can be used advantageously conventional packaging for cosmetic preparations, in particular deodorants and / or antiperspirants, z. As aerosols, atomizers, pen dispensers, money dispensers, tubes and scooters. The numerical values given in the examples relate to percent by weight relative to the total mass of the preparation.

Example Recipes: Roll On

Raw material Example 1 Example 2 Example 3 Example 4

1, 3-propylene glycol 30.00% 15.00%

1, 3-Butylene glycol 30.00%

Phenyl-1, 3-propylene glycol 20.00%

Polyethylene glycol (21) stearyl ether 2.00% 2.00% 2.00% 2.00%

Polyethylene glycol (2) stearyl ether 2.50% 2.50% 2.50% 2.50%

Polypropylene glycol (15) stearyl ether 3.00% 3.00% 3.00% 3.00%

EDTA 1, 50% 1, 50% 1, 50% 1, 50%

Perfume, Antioxidants q.s. q.s. q.s. q.s.

Water ad 100% ad 100% ad 100% ad 100%

Raw material Example 5 Example 6 Example 7

1, 3-propylene glycol 20.00% 10.00%

1, 3-Butylene glycol 20.00% 10.00%

PPG-1-PEG-9-lauryl glycol ether 3.00% 3.00% 3.00%

Methylpropanediol 2.00% 2.00% 2.00%

Ethylhexylglycerol 0.70% 0.70% 0.70%

Carbomer 0.10% 0.10% 0.10%

Hydroxyethylcellulose 0.10% 0.10% 0.10%

Sodium Hydroxide 0.05% 0.05% 0.05%

Glyoxal 0.10% 0.10% 0.10%

Perfume q.s. q.s. q.s.

Deodorant q.s. q.s. q.s.

Water ad 100% ad 100% ad 100%

Example recipe: aerosols

Raw material Example 8 Example 9 Example 10

1, 3-propylene glycol 30.00% 30.00%

2.5 hexanediol 30.00%

Caprylic / Capric Triglycerides 10.00% 10.00% 10.00% Dicaprylyl ether 5.00% 5.00% 5.00%

PEG-45 / dodecyl glycol copolymer 1, 50% 1, 50%

PEG-22 / dodecyl glycol copolymer 1, 20%

Polyglyceryl-3 diisotearate 1, 50% 1, 50% 1, 20%

Magnesium Sulfate 0.20%

Perfume, anitoxidants q.s. q.s.

Deodorant q.s. q.s.

Water ad 100% ad 100% ad 100%

Filling ratio: 30 wt.% Active ingredient solution in 70 wt.% Propane / butane / isobutane

Example recipe: atomizer

Raw material Example 11 Example 12 Example 13

1, 3-propylene glycol 20.00% 10.00%

2.5 hexanediol 20.00% 10.00% isoceteth-20 4.80% 4.80%

Dicaprylyl Ether 3.00% 3.00%

Glyceryl isostearate 2.40% 2.40%

Polyether-1 1, 00% 1, 00%

Deodorant q.s. q.s.

Perfume q.s. q.s.

Water ad 100% ad 100%

Claims

claims

1. Use of diols of the structure

where the radicals R are selected

R2, R3 and R4 = OH ₁ CH2 - OH, CH3, C2H5, H, wherein two OH groups in the molecule are present, the maximum number C of all the radicals R2, R3 and R4 is not greater than 6, and vicinal diols with a C atomic numbers from 2 to 6 are excluded as an antiperspirant and / or antiperspirant active substance.

2. Use according to claim 1, characterized in that 1, 3-propylene glycol, 1, 3-butylene glycol, 2,4-pentylene glycol and / or 2,5-hexanediol is selected as antiperspirant and / or antiperspirant active ingredient.

3. Use according to claim 1 or 2, characterized in that the diols are present in topically administrable, in particular cosmetic, preparations.

4. Use according to claim 3, characterized in that the diols to 10 to 50 wt.%, In particular 15 to 30 wt.%, Based on the total mass of the preparation, are included.

5. Use according to one of claims 3 or 4, characterized in that the diols are used in combination with other antiperspirant active diols.

6. Use according to one of claims 1 to 2 as the sole antiperspirant active in cosmetic preparations.