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WO2010076564A3 - Isochromenones useful in the treatment of inflammation - Google Patents

Isochromenones useful in the treatment of inflammation Download PDF

Info

Publication number
WO2010076564A3
WO2010076564A3 PCT/GB2009/002974 GB2009002974W WO2010076564A3 WO 2010076564 A3 WO2010076564 A3 WO 2010076564A3 GB 2009002974 W GB2009002974 W GB 2009002974W WO 2010076564 A3 WO2010076564 A3 WO 2010076564A3
Authority
WO
WIPO (PCT)
Prior art keywords
useful
inflammation
treatment
isochromenones
pde4
Prior art date
Application number
PCT/GB2009/002974
Other languages
French (fr)
Other versions
WO2010076564A2 (en
Inventor
Benjamin Pelcman
James Gee Ken Yee
Lloyd F. Mackenzie
Yuanlin Zhou
Kang Han
Original Assignee
Biolipox Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolipox Ab filed Critical Biolipox Ab
Publication of WO2010076564A2 publication Critical patent/WO2010076564A2/en
Publication of WO2010076564A3 publication Critical patent/WO2010076564A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention is directed to compounds of formula (I): wherein R1, R2, R3, Rx, Ry, m and n have meanings given in the description, or pharmaceutically acceptable salts, solvates or prodrugs thereof, which are useful as PDE4, PDE7 or PDE4 and PDE7 inhibitors, and therefore useful e.g. in the treatment and/or prevention of diseases and conditions associated with inflammation.
PCT/GB2009/002974 2008-12-30 2009-12-30 Isochromenones useful in the treatment of inflammation WO2010076564A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19383808P 2008-12-30 2008-12-30
US61/193,838 2008-12-30

Publications (2)

Publication Number Publication Date
WO2010076564A2 WO2010076564A2 (en) 2010-07-08
WO2010076564A3 true WO2010076564A3 (en) 2010-11-18

Family

ID=42310263

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/002974 WO2010076564A2 (en) 2008-12-30 2009-12-30 Isochromenones useful in the treatment of inflammation

Country Status (1)

Country Link
WO (1) WO2010076564A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103539642A (en) * 2013-08-26 2014-01-29 上海应用技术学院 Method for preparing 3,4,5-trimethoxy-3'-hydroxy-4'-alkoxy diphenylethane
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
WO2024038089A1 (en) 2022-08-18 2024-02-22 Mitodicure Gmbh Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4523547B1 (en) * 1967-07-29 1970-08-07
JPS5371076A (en) * 1976-12-04 1978-06-24 Mitsui Toatsu Chem Inc Novel isocoumarin derivs.
JPH10330260A (en) * 1997-05-30 1998-12-15 Nippon Kayaku Co Ltd Phosphodiesterase inhibitor and production thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4523547B1 (en) * 1967-07-29 1970-08-07
JPS5371076A (en) * 1976-12-04 1978-06-24 Mitsui Toatsu Chem Inc Novel isocoumarin derivs.
JPH10330260A (en) * 1997-05-30 1998-12-15 Nippon Kayaku Co Ltd Phosphodiesterase inhibitor and production thereof

Also Published As

Publication number Publication date
WO2010076564A2 (en) 2010-07-08

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