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WO2010057242A3 - Vakzin - Google Patents

Vakzin Download PDF

Info

Publication number
WO2010057242A3
WO2010057242A3 PCT/AT2009/000452 AT2009000452W WO2010057242A3 WO 2010057242 A3 WO2010057242 A3 WO 2010057242A3 AT 2009000452 W AT2009000452 W AT 2009000452W WO 2010057242 A3 WO2010057242 A3 WO 2010057242A3
Authority
WO
WIPO (PCT)
Prior art keywords
seq
vaccine
acid sequence
amino acid
peptide
Prior art date
Application number
PCT/AT2009/000452
Other languages
English (en)
French (fr)
Other versions
WO2010057242A2 (de
Inventor
Sylvia Brunner
Pola Linzmayer-Hirt
Walter Schmidt
Bettina Wanko
Gabriele Winsauer
Christina Woess
Original Assignee
Affiris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affiris Ag filed Critical Affiris Ag
Publication of WO2010057242A2 publication Critical patent/WO2010057242A2/de
Publication of WO2010057242A3 publication Critical patent/WO2010057242A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0012—Lipids; Lipoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Vakzin umfassend mindestens ein von der Aminosäuresequenz TLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIA (SEQ ID Nr. 1) abgeleitetes Peptid mit einer Mindestlänge von 7 Aminosäuren, wobei das Peptid die Aminosäuresequenz DIIGA (SEQ ID Nr. 2) und/oder CFVSQSG (SEQ ID Nr. 3) von SEQ ID Nr. 1 mitumfasst.
PCT/AT2009/000452 2008-11-19 2009-11-19 Vakzin WO2010057242A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0180008A AT507604A1 (de) 2008-11-19 2008-11-19 Behandlung von atherosklerose
ATA1800/2008 2008-11-19

Publications (2)

Publication Number Publication Date
WO2010057242A2 WO2010057242A2 (de) 2010-05-27
WO2010057242A3 true WO2010057242A3 (de) 2010-09-16

Family

ID=42026338

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT2009/000452 WO2010057242A2 (de) 2008-11-19 2009-11-19 Vakzin

Country Status (2)

Country Link
AT (1) AT507604A1 (de)
WO (1) WO2010057242A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012002639A (es) 2009-09-03 2012-03-14 Pfizer Vaccines Llc Vacuna de pcsk9.
GB201005005D0 (en) * 2010-03-25 2010-05-12 Angeletti P Ist Richerche Bio New vaccine
EP2450382A1 (de) * 2010-11-04 2012-05-09 Affiris AG Immunogenes Peptid
EP2532359A1 (de) 2011-06-10 2012-12-12 Affiris AG CETP-Fragmente
SI2570135T1 (sl) 2011-09-13 2016-05-31 Affiris Ag PCSK9 cepivo
EP3104877B1 (de) 2014-02-11 2020-01-22 The USA, as represented by The Secretary, Department of Health and Human Services Pcsk9-impfstoff und verfahren zur verwendung davon
US10557129B2 (en) * 2015-01-30 2020-02-11 Pronasci Inc. Peptides derived from human PCSK9 catalytic domain and uses thereof for promoting LDL-R activity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008063382A2 (en) * 2006-11-07 2008-05-29 Merck & Co., Inc. Antagonists of pcsk9
WO2008105797A2 (en) * 2006-06-30 2008-09-04 Bristol-Myers Squibb Company Polynucleotides encoding novel pcsk9 variants
WO2008125623A2 (en) * 2007-04-13 2008-10-23 Novartis Ag Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (pcsk9)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008105797A2 (en) * 2006-06-30 2008-09-04 Bristol-Myers Squibb Company Polynucleotides encoding novel pcsk9 variants
WO2008063382A2 (en) * 2006-11-07 2008-05-29 Merck & Co., Inc. Antagonists of pcsk9
WO2008125623A2 (en) * 2007-04-13 2008-10-23 Novartis Ag Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (pcsk9)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SOUTAR ANNE K ET AL: "Mechanisms of disease: genetic causes of familial hypercholesterolemia", NATURE CLINICAL PRACTICE. CARDIOVASCULAR MEDICINE, NATURE PUBLISHING GROUP, GB, vol. 4, no. 4, 1 April 2007 (2007-04-01), pages 214 - 225, XP009131428, ISSN: 1743-4300 *
WANG L-F ET AL: "EPITOPE IDENTIFICATION AND DISCOVERY USING PHAGE DISPLAY LIBRARIES: APPLICATIONS IN VACCINE DEVELOPMENT AND DIAGNOSTICS", CURRENT DRUG TARGETS, BENTHAM SCIENCE PUBLISHER, US, vol. 5, no. 1, 1 January 2004 (2004-01-01), pages 1 - 15, XP009047802, ISSN: 1389-4501 *

Also Published As

Publication number Publication date
WO2010057242A2 (de) 2010-05-27
AT507604A1 (de) 2010-06-15

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