WO2010054510A1

WO2010054510A1 - Surgical microscope system having angiography function

Info

Publication number: WO2010054510A1
Application number: PCT/CN2008/073017
Authority: WO
Inventors: 王辉; 何永红; 李鹏; 吴蕾
Original assignee: 深圳市莫廷影像技术有限公司
Priority date: 2008-11-11
Filing date: 2008-11-11
Publication date: 2010-05-20
Also published as: CN201664343U

Abstract

A surgical microscope system having an angiography function includes a microscope module (10) and a blood vessel developing module (20). The microscope module (10) includes an illuminating source (11) and an illuminating optics micrograph system. The illuminating optics micrograph system includes a first spectroscope (15),the blood vessel developing module (20) includes an excitation light source (21) and a fluoroscopic video unit. According to the following manner to constitute an optic road: at least part of the illuminating light reflecting from the observed matter (14) micrograph images after transmitting through the first spectroscope (15),at least part of the excitated light emitted by the excitation light source (21) reflects on the observed matter (14) through the first spectroscope (15),the observed matter (14) is excitated out the fluorescence by the excitated light emitting back the blood vessel developing module (20) along the excitated light coming road, and taken by the fluoroscopic video unit.

Description

Surgical microscope system with angiography

The utility model relates to the technical field of optical microscopic imaging, in particular to an operating microscope system with an angiographic function. Background technique

Microscopes have been used in biomedical fields for hundreds of years, and direct use of microscopes for surgical procedures began in 1925. The operation of the surgical microscope enables the doctor to see the fine structure of the surgical site, and can perform various microscopic operations that cannot be performed by the naked eye, greatly expanding the scope of surgical treatment, and improving the accuracy of surgery and the rate of healing of patients. Surgery microscope has become a kind of conventional medical equipment, mainly used for surgery and examination in various clinical departments of hospitals.

1 is a schematic view of a conventional surgical microscope 10. Light emitted from an illumination source (e.g., xenon lamp) 11 is totally reflected by the beam splitter 12, concentrated by the objective lens 13 onto the sample 14, and the backscattered light passing through the sample 14 passes through the objective lens 13, 16, and finally enters the observer (surgery Person) Human eye 17.

However, traditional surgical microscopes have nothing to do with many difficult diseases such as brain and liver tumors, cardiovascular and fundus diseases. These diseases are often located in dense blood vessels, making it difficult to distinguish the fine structure and dynamic state of blood vessels.

In addition, angiographic techniques are known to be mainly: fluorescein angiography (Fundus fluorescein angiography, FIF), indocyanine green angiography (ICGA). The inspection steps for both are basically the same, except that the contrast agent and filter are different. The traditional device of the illuminator is shown in Figure 2. The excitation light emitted from the excitation light source 31 is irradiated to the subject 32 to which the contrast agent has been injected, and the subject 32 is irradiated with the excitation light to generate fluorescence, which is filtered by the filter 33 and projected onto the imaging device 34 for imaging. . Existing contrast techniques are often used to inspect and diagnose subjects. Summary of the invention

The main purpose of the utility model is to solve the problems in the prior art and provide an angiography A functional surgical microscope system that enables the implementation of the procedure to be more objective and accurate. In order to achieve the above object, the utility model adopts the following technical solutions:

An operating microscope system having an angiographic function, comprising a microscope module, the microscope module comprising an illumination source and an illumination optical microscopy system located on the illumination light path and magnifying and imaging the observed object with the illumination light, the operation microscope system Characterized by: further comprising a blood vessel developing module, the illumination optical microscopy system comprising a first beam splitter, the blood vessel developing module comprising an excitation light source and a fluorescence imaging unit, the first beam splitter, the excitation light source, and the The fluorescence imaging unit constitutes an optical path, and the illumination light reflected from the observed object is at least partially transmitted through the first beam splitter and then microscopically imaged, and the excitation light emitted by the excitation light source is at least partially reflected by the first beam splitter After being incident on the object to be observed, the fluorescence excited by the excitation light of the observed object is incident back to the blood vessel development module along the path of the excitation light, and is taken up by the fluorescence imaging unit.

Preferably:

The blood vessel developing module further includes a second beam splitter, wherein the second beam splitter is disposed as follows, after the excitation light is at least partially transmitted through the second beam splitter, the transmitted portion is incident on the first The spectroscope, after the fluorescence is at least partially reflected by the second spectroscope, the reflected portion is further taken by the fluorescence imaging unit.

The observed object adopts indocyanine green angiography, the excitation light source is a light source with a center wavelength of 810 nm, and the first beam splitter is a spectroscope for visible light transflective and infrared total reflection, and the second beam splitter is A beam splitter that transmits 820 nm or less at a wavelength of 820 nm or more, and the fluorescence image pickup unit includes a near-infrared image pickup unit.

The observed object is fluorescein sodium angiography, the excitation light source is a light source with a center wavelength of 490 nm, the first beam splitter is a visible light semi-transmissive semi-reflective beam splitter, and the second beam splitter is at a wavelength of 515 nm-525 nm. A narrow band filter that reflects other wavelengths is reflected, and the fluorescence imaging unit includes a green light imaging unit.

The observed object is observed by aminolevulinic acid hydrochloride, the excitation light source is a light source with a center wavelength of 400 nm, and the first beam splitter is a dichroic mirror with visible light transflective and ultraviolet light total reflection. The second beam splitter is a narrow band filter that reflects other wavelengths at a wavelength of 640-650 nm, and the fluorescence camera unit includes a red light camera unit.

The excitation source is a light emitting diode or a super luminescent diode or a laser diode.

The blood vessel development module further includes a third beam splitter and a visible light imaging unit, and the first beam splitter is a spectroscope having at least a semi-reflective visible light, wherein the third dichroic mirror is a spectroscope that transmits the excitation light and at least partially reflects the visible light, and the third spectroscope and the visible light imaging unit are disposed as follows: The visible light reflected back by the spectroscope is at least partially reflected by the third beam splitter, and the reflected portion is further taken by the visible light imaging unit.

The second beam splitter is closer to the first beam splitter than the third beam splitter and further away from the excitation light source.

The second beam splitter is closer to the excitation light source than the third beam splitter and further away from the first beam splitter.

The blood vessel development module further includes a first converging lens disposed adjacent to the excitation light source on the optical path of the excitation light and a second converging lens disposed adjacent to the first dichroic mirror. The beneficial technical effects of the utility model are:

1. The surgical microscope system of the present invention not only has a conventional illumination optical microscopy system, but also provides a first beam splitter in the illumination optical microscopy system, and the system further includes a blood vessel development module including an excitation light source and a fluorescence imaging unit. The illumination light reflected from the observed object is at least partially transmitted through the first beam splitter and then microscopically imaged, and the excitation light emitted by the excitation source is at least partially reflected by the first beam splitter and then incident on the object to be observed, and the observed object is excited by the light. The excited fluorescence is emitted back to the blood vessel development module along the path of the excitation light, and is taken up by the fluorescence imaging unit. Thus, with the surgical microscope system of the present invention, the doctor observes through the surgical microscope system during the operation and also passes the operation. The microscope system's imaging of the angiographic vessels allows doctors to perform more accurate surgery with the angiographic imaging information, and also improve the efficiency of the surgery, and retain the dynamic surgical process information that is ingested for subsequent diagnosis and Evaluation.

2. According to the utility model, the angiographic imaging device can be combined without changing the traditional surgical microscope device, which not only reduces the production cost, but also has a modular design, so that the developing module can be conveniently combined on other microscopic devices. It embodies the flexibility of the design and facilitates the operation of the doctor. DRAWINGS

Figure 1 is a schematic view showing the structure of a conventional surgical microscope;

2 is a schematic structural view of a conventional device of a contrast device;

3 is a schematic structural view of an embodiment of a surgical microscope system of the present invention;

Figure 4 is a schematic structural view of the blood vessel developing module of Figure 3;

5 is a schematic structural view of another embodiment of the surgical microscope system of the present invention; The features and advantages of the present invention will be described in detail by the embodiments and the accompanying drawings. detailed description

Embodiment 1

Referring to FIG. 3, the surgical microscope system with contrast function includes a microscope module 10 and a blood vessel development module 20

Among them, the microscope module 10 includes a visible illumination source 11 and an illumination light microscope system. Illumination source 11 High-power halogen or xenon lamps can be used for uniform and sufficient intensity illumination. The illumination light microscopy system includes a fourth beam splitter 12, a first objective lens 13, a first beam splitter 15 and a second objective lens 16. The first beam splitter 15 preferably employs an infrared total reflection visible light transflective filter.

The blood vessel development module of this embodiment is provided for ICG contrast. As shown in Figs. 3 and 4, the blood tube developing module includes an excitation light source 21, an excitation optical system, and an image pickup device. The excitation light source 21 may be an LED (Light Emitting Diode) or SLED (Super Emission Light Emitting Diode) or LD (Laser Diode) having a central wavelength of preferably 810. The excitation optical system includes a second beam splitter 22, a third beam splitter 24, an adjustable first converging lens f1 and a second converging lens f2 disposed in the transponder housing 2 (the lens referred to herein is not limited to a single lens) , also covers a lens group composed of multiple lenses). The second dichroic mirror 22 is preferably a filter that transmits a wavelength of 820 nm or more and reflects a wavelength of 820 nm or less, and the third beam splitter 24 reflects a filter that transmits infrared light with visible light. The image pickup apparatus includes a near-infrared image pickup unit 23 and a visible light image pickup unit 25. The near-infrared camera unit 23 includes a lens and aperture 23a, a coupling ring of the lens and the camera 23b CCD (Charge Coupled Device) 23c, and a unit 23d connected to the control element of the CCD 23C.

The operating microscope system works as follows:

The light emitted by the illumination source 11 is reflected by the fourth beam splitter 12, and is concentrated by the first objective lens 13 onto the object 14 to be detected. The light backscattered by the object 14 passes through the first objective lens 13, the first beam splitter 15 and The second objective lens 16 finally enters the viewer's human eye 17

When performing ICG development, the light emitted by the excitation light source 21 is concentrated into a uniform spot 2 through the first converging lens ,, and then becomes parallel light through the third beam splitter 24, the second beam splitter 22, and the second condenser lens f2. The parallel light is irradiated onto the detected biological tissue via the first beam splitter 15 and the first objective lens 13. Since the ICG maximum absorption wavelength is 805 nm and the maximum excitation wavelength is 835 nm, the spectrum of the reflected signal light changes. After the signal light passes through the first objective lens 13 and the first beam splitter 15, a part of the signal light enters the human eye through the second objective lens 16, and the other part of the signal light passes through the second condenser lens f2, and is filtered by the second beam splitter 22. , projected onto the infrared light imaging element 23, and transmitted through the third light splitting After the mirror 24 reflects the light, it is projected onto the visible light imaging element 25.

The excitation source 21 is preferably obtained from a source module with the visible illumination source 11 through which the desired excitation light is achieved.

The contrast agent is quickly injected into the vein of the subject, and the surgical microscope system of the present invention can be used to observe or photograph the operation. Because the contrast agent runs with the blood flow, the shape of the blood vessel can be dynamically delineated, and the fluorescence imaging is added to improve the contrast and visibility of the blood vessel, so that some minor blood vessel changes can be recognized. The continuous imaging with fluorescence imaging makes the surgical results more objective, accurate and dynamic. Moreover, the obtained information has valuable value for clinical diagnosis, prognosis evaluation, treatment, therapeutic observation and pathogenesis. Embodiment 2

This embodiment differs from the embodiment in that the blood vessel developing module is provided for the application using the photosensitizer 5-ALA (salt amino levulinic acid) as a contrast agent. The maximum absorption wavelength of 5-ALA hydrochloric acid aminolevulinic acid is 400 nm, and the excitation wavelength is red light of 645 nm. Accordingly, the excitation light source 21 preferably has an ultraviolet light source with a center wavelength of 400 nm, and the first beam splitter 15 preferentially adopts visible light transflective and The ultraviolet light total reflection dichroic mirror and the third beam splitter 24 preferably use a short wavelength transmission filter such as ultraviolet light transmission and visible light reflection, and the second beam splitter 22 preferably uses a narrow band filter having a center wavelength of 645 nm, such as a wavelength. 640nm-650nm reflection, other band transmission, the near-infrared camera unit 23 is replaced by a red light camera unit, and the focal lengths of the first and second condenser lenses fl, f2 are correspondingly changed. Since the light source used is ultraviolet light, in order to prevent the ultraviolet light from harming the human eye, a filter 18 should be added before the human eye receives the light to filter out the ultraviolet light. The working principle of this embodiment is similar to that of the first embodiment, and details are not described herein. Embodiment 3

This embodiment differs from the embodiment in that the blood vessel development module is provided for an application using sodium fluorescein as a contrast agent. The fluorescein absorbs blue light having a wavelength of 490 nm and emits green light having a wavelength of 520 nm. Accordingly, the excitation light source 21 preferably has a light source having a center wavelength of 490 nm, and the first beam splitter 15 and the third beam splitter 24 preferably use a visible light transflective filter. The second beam splitter 22 preferably uses a narrowband filter with a center wavelength of 520 nm, for example, 515 _525 reflection, and other wavelengths, and the near-infrared camera unit 23 is replaced by a green light camera unit. Meanwhile, the first and second condenser lenses fl, f2 The focal length has a corresponding change. The working principle of this embodiment is similar to that of the first embodiment, and details are not described herein. In various embodiments, the second beam splitter 22, the position of the image pickup element 23 and the third beam splitter 24, The position of the visible light imaging element 25 can be reversed accordingly. Since the spectroscope is generally highly reflective, the foregoing embodiment is preferred in that the second dichroic mirror 22 is disposed closer to the excitation light source 21 than the third dichroic mirror 24 is closer to the first dichroic mirror 15 than the first dichroic mirror 24. .

Further, as shown in Fig. 5, in the alternative embodiment, the third dichroic mirror 24 and the visible light imaging unit 2 in the blood vessel developing module can also be omitted. It will be appreciated that while the preferred addition of the third beam splitter 24 and the visible light imaging unit 2 enables the present system to increase the ability to capture visible light, as a preferred example, these improved features are not essential to the present invention.

The above is a further detailed description of the present invention in conjunction with the specific preferred embodiments. It is not intended that the specific embodiments of the invention are limited to the description. For those skilled in the art to which the present invention pertains, it should be considered that the present invention is not limited to the scope of the present invention.

Claims

Claim

What is claimed is: 1. A surgical microscope system having an angiographic function, comprising a microscope module, the microscope module comprising an illumination source and an illumination optical microscopy system positioned on the illumination light path and magnifying and imaging the object with the illumination light, characterized in that Also included is a blood vessel development module, the illumination optical microscopy system including a first beam splitter, the blood vessel development module including an excitation light source and a fluorescence imaging unit, the first beam splitter, the excitation light source, and the fluorescence imaging unit Forming an optical path in which the illumination light reflected from the observed object is at least partially transmitted through the first beam splitter and then microscopically imaged, and the excitation light emitted by the excitation light source is at least partially reflected by the first beam splitter and then incident on On the observed object, the fluorescence of the observed object excited by the excitation light is emitted back to the blood vessel development module along the path of the excitation light, and is taken up by the fluorescence imaging unit.

The surgical microscope system according to claim 1, wherein the blood vessel development module further comprises a second beam splitter, the second beam splitter being disposed as follows, the excitation light being at least partially transmitted through the After the second beam splitter, the transmitted portion is incident on the first beam splitter, and the fluorescence is at least partially reflected by the second beam splitter, and the reflected portion is taken by the fluorescence image capturing unit.

The surgical microscope system according to claim 2, wherein the observed object is indocyanine green, the excitation light source is a light source having a center wavelength of 810 nm, and the first beam splitter is visible light semi-transmission. A semi-reflective and infrared total reflection spectroscope, wherein the second dichroic mirror is a spectroscope that transmits at a wavelength of 820 nm or more and reflects 820 nm or less, and the fluorescence imaging unit includes a near-infrared imaging unit.

The surgical microscope system according to claim 2, wherein the observed object is fluorescein sodium contrast, and the first beam splitter is a visible light semi-transmissive semi-reflective beam splitter, the excitation light source is centered A light source having a wavelength of 490 nm, the second beam splitter is a narrow band filter that reflects other wavelengths at a wavelength of 515 nm to 525 nm, and the fluorescence image pickup unit includes a green light image pickup unit.

The surgical microscope system according to claim 2, wherein the observed object is imaged with an aminolevulinic acid photosensitizer, the excitation light source is a light source having a center wavelength of 400 nm, and the first beam splitter The dichroic mirror is a semi-transmissive and semi-reflective ultraviolet light, and the second dichroic mirror is a narrow-band filter that reflects other wavelengths at a wavelength of 640-650 nm, and the fluorescent imaging unit includes a red light-emitting unit.

The surgical microscope system according to any one of claims 1 to 5, wherein the excitation light source is a light emitting diode or a super luminescent diode or a laser diode.

The surgical microscope system according to any one of claims 1 to 5, wherein the blood The tube developing module further includes a third beam splitter and a visible light imaging unit, wherein the first beam splitter is a beam splitter that is at least semi-reflected by visible light, and the third beam splitter is a beam splitter that transmits the excitation light and at least partially reflects the visible light. The third beam splitter and the visible light imaging unit are disposed in such a manner that the visible light reflected by the first beam splitter is at least partially reflected by the third beam splitter, and the reflected portion is further reflected by the visible light image capturing unit. Ingestion.

8. The surgical microscope system of claim 7, wherein the second beam splitter is further from the first beam splitter than the first beam splitter and further from the excitation source.

9. The surgical microscope system of claim 7, wherein the second beam splitter is further from the excitation beam than the first beam splitter from the first beam splitter.

10. The surgical microscope system according to claim 7, wherein the blood vessel development module further comprises a first converging lens disposed adjacent to the excitation light source on the optical path of the excitation light and adjacent to the first beam splitter The second converging lens.