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WO2009111623A3 - Amorphous varenicline tartrate - Google Patents

Amorphous varenicline tartrate Download PDF

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Publication number
WO2009111623A3
WO2009111623A3 PCT/US2009/036157 US2009036157W WO2009111623A3 WO 2009111623 A3 WO2009111623 A3 WO 2009111623A3 US 2009036157 W US2009036157 W US 2009036157W WO 2009111623 A3 WO2009111623 A3 WO 2009111623A3
Authority
WO
WIPO (PCT)
Prior art keywords
varenicline tartrate
amorphous
amorphous varenicline
tartrate
processes
Prior art date
Application number
PCT/US2009/036157
Other languages
French (fr)
Other versions
WO2009111623A2 (en
Inventor
Subba Reddy Peddireddy
Arjun Kumar Tummala
Jaydeepkumar Dahyabhai Lilakar
Srirami Reddy Kikkuru
Ramchandra Reddy Pingili
Srinivasan Neti
Swarupa Dudipala
Madhu Raju Veera Boina
Ramalinga Reddy Beeravalli
Sundara Lakshmi Kanniah
Vamsee Krishna Muppidi
Original Assignee
Dr. Reddy's Laboratories Ltd.
Dr. Reddy's Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Laboratories Ltd., Dr. Reddy's Laboratories, Inc. filed Critical Dr. Reddy's Laboratories Ltd.
Priority to EP09716470A priority Critical patent/EP2262780A4/en
Publication of WO2009111623A2 publication Critical patent/WO2009111623A2/en
Publication of WO2009111623A3 publication Critical patent/WO2009111623A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Amorphous varenicline tartrate, amorphous solid dispersions of varenicline tartrate and a pharmaceutical carrier, and processes for the preparation thereof.
PCT/US2009/036157 2008-03-06 2009-03-05 Amorphous varenicline tartrate WO2009111623A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09716470A EP2262780A4 (en) 2008-03-06 2009-03-05 Amorphous varenicline tartrate

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN571CH2008 2008-03-06
IN571/CHE/2008 2008-03-06
US7384408P 2008-06-19 2008-06-19
US61/073,844 2008-06-19

Publications (2)

Publication Number Publication Date
WO2009111623A2 WO2009111623A2 (en) 2009-09-11
WO2009111623A3 true WO2009111623A3 (en) 2009-12-10

Family

ID=41056650

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/036157 WO2009111623A2 (en) 2008-03-06 2009-03-05 Amorphous varenicline tartrate

Country Status (2)

Country Link
EP (1) EP2262780A4 (en)
WO (1) WO2009111623A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010143070A2 (en) 2009-06-10 2010-12-16 Actavis Group Ptc Ehf Amorphous varenicline tartrate co-precipitates
US20120004239A1 (en) 2010-06-11 2012-01-05 Medichem, S.A. Process for Preparing Quinoxaline Derivatives
WO2013160916A1 (en) * 2012-04-25 2013-10-31 Hetero Research Foundation Sunitinib malate solid dispersion
CN104478803A (en) * 2014-12-19 2015-04-01 连云港恒运医药科技有限公司 Preparation method of varenicline intermediate and nitroreduction impurity thereof
KR20180101268A (en) * 2017-03-03 2018-09-12 주식회사 씨티씨바이오 Oral dosage formulation comprising inclusion complex of the Varenicline or a pharmaceutically acceptable salt thereof
US11602537B2 (en) 2022-03-11 2023-03-14 Par Pharmaceutical, Inc. Varenicline compound and process of manufacture thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092089A1 (en) * 2001-05-14 2002-11-21 Pfizer Products Inc. Tartrate salts of 5,8,14-triazatetracyclo {10.3.1.0?2,11.04,9¿}-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof
US6558435B2 (en) * 2000-05-26 2003-05-06 Pfizer, Inc. Reactive crystallization method to improve particle size
WO2007012963A1 (en) * 2005-07-26 2007-02-01 Pfizer Products Inc. Transdermal system for varenicline

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5683720A (en) * 1994-10-28 1997-11-04 Fuisz Technologies Ltd. Liquiflash particles and method of making same
WO2006040680A1 (en) * 2004-10-15 2006-04-20 Pfizer Products Inc. Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline
EP1843769A1 (en) * 2005-01-07 2007-10-17 Pfizer Products Incorporated Fast-disintegrating dosage forms of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558435B2 (en) * 2000-05-26 2003-05-06 Pfizer, Inc. Reactive crystallization method to improve particle size
WO2002092089A1 (en) * 2001-05-14 2002-11-21 Pfizer Products Inc. Tartrate salts of 5,8,14-triazatetracyclo {10.3.1.0?2,11.04,9¿}-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof
WO2007012963A1 (en) * 2005-07-26 2007-02-01 Pfizer Products Inc. Transdermal system for varenicline

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NIAURA, RAYMOND ET AL.: "Varenicline", NATURE REVIEWS DRUG DISCOVERY, vol. 5, no. 7, 2006, pages 537 - 538, XP008138247 *
See also references of EP2262780A4 *

Also Published As

Publication number Publication date
WO2009111623A2 (en) 2009-09-11
EP2262780A2 (en) 2010-12-22
EP2262780A4 (en) 2012-01-25

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