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WO2009036714A1 - Composition for the treatment of wounds, containing at least silver and urea - Google Patents

Composition for the treatment of wounds, containing at least silver and urea Download PDF

Info

Publication number
WO2009036714A1
WO2009036714A1 PCT/DE2008/001083 DE2008001083W WO2009036714A1 WO 2009036714 A1 WO2009036714 A1 WO 2009036714A1 DE 2008001083 W DE2008001083 W DE 2008001083W WO 2009036714 A1 WO2009036714 A1 WO 2009036714A1
Authority
WO
WIPO (PCT)
Prior art keywords
silver
composition
urea
wounds
hyaluronic acid
Prior art date
Application number
PCT/DE2008/001083
Other languages
German (de)
French (fr)
Inventor
Peter G. Deckner
Original Assignee
Deckner Peter G
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deckner Peter G filed Critical Deckner Peter G
Publication of WO2009036714A1 publication Critical patent/WO2009036714A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Definitions

  • compositions known from the prior art their efficacy may be given on an individual basis, but on a broad basis they are not effective, which is due to the still enormous number of patients with bad or non-healing wounds see is.
  • a treatment solution for chronic wound treatment can be found in DE 101 40 623 A1.
  • the treatment solution is an aqueous solution containing per liter of solution besides water and preferably sulfuric acid 10 to 100 mg of zinc, 6.5 to 65 mg of iron and in a further development the growth factor PDGF.
  • the proportion of acid is adjusted so that the pH is between 2.5 and 3.5.
  • a composition for wound treatment with a proportion of silver salt compounds can be taken from WO 2006/034249 A2.
  • composition contains, in addition to the abovementioned substances, at least one physiologically and pharmacologically acceptable carrier or excipient.
  • composition according to the invention may comprise further active ingredients and / or ingredients familiar to the person skilled in the art, in particular processing substances, stabilizers, emulsifiers, antiseptics, antioxidants, preservatives, humectants or the like.
  • composition for wound treatment characterized in that it contains up to 0.9 g hyaluronic acid, 0.1 to 40.0 g urea and 0.1 g to Ig colloidal silver.
  • composition according to the invention can be present in various forms, ie as spray, ointment, gel, suspension, powder, washing lotion, tincture, gauze, wound dressing, impregnated wound dressing, foam or sponge.
  • spray ointment
  • gel suspension
  • powder washing lotion
  • tincture gauze
  • wound dressing impregnated wound dressing
  • foam or sponge for more details on the terms ointment, paste, cream, gel reference is made to the relevant keywords in Römpp, Lexicon Chemistry 10th edition, Georg Thieme Verlag, Stuttgart / New York.
  • the composition brings about local antibiosis (sterility), wound cleansing, the dissolution of necroses, granulation promotion, the protection of the wound and the wound environment, and epithelization (stable strengthening of the cell complex).
  • composition in spray form allows the use of a button probe with which the spray is applied e.g. can be applied to fistulas in fistula canals, wound bags, deep and ragged wounds, anal areas, poorly accessible wounds, body cavities and pressure sores.
  • composition for an ointment Composition for an ointment
  • composition according to the invention it is also possible to heal open wounds for years within a few months.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed is a composition for the treatment of wounds, containing hyaluronic acid, urea, and colloidal silver.

Description

ZUSAMMENSETZXMG FÜR WUNDBEHANDLUNGEN ENTHALTEND ZUMINDEST SILBER UND HARNSTOFFCOMPOSITIONXMG FOR WOUND TREATMENTS CONTAINING AT LEAST SILVER AND UREA
Die vorliegende Erfindung betrifft Zusammensetzungen zur Behandlung von Wunden, insbesondere schlecht oder nicht heilender offener Wunden.The present invention relates to compositions for the treatment of wounds, particularly poor or non-healing open wounds.
Es ist bekannt, dass bei Menschen Wunden auftreten können, deren Heilung sich über Jahre hinzieht oder überhaupt nicht erreicht werden kann, sodass diese Wunden chronisch offen bleiben.It is well-known that in humans, wounds can occur whose healing goes on for years or can not be achieved at all, so that these wounds remain chronically open.
Für alle aus dem Stand der Technik bekannten Zusammensetzungen ist leider zu sagen, dass ihre Wirksamkeit zwar im Einzelfall gegeben sein kann, auf breiter Basis sind sie aber nicht wirksam, was durch die nach wie vor enorme Zahl an Patienten mit schlecht oder nicht verheilenden Wunden zu sehen ist.Unfortunately, for all compositions known from the prior art, their efficacy may be given on an individual basis, but on a broad basis they are not effective, which is due to the still enormous number of patients with bad or non-healing wounds see is.
Eine Behandlungslösung zur chronischen Wundbehandlung ist aus der DE 101 40 623 Al zu entnehmen. Die Behandlungslösung ist eine wässrige Lösung, die pro Liter Lösung neben Wasser und vorzugsweise Schwefelsäure 10 bis 100 mg Zink, 6,5 bis 65 mg Eisen und in einer Weiterentwicklung den Wachstumsfaktor PDGF enthält. Der Anteil an Säure ist so eingestellt, dass der pH- Wert zwischen 2,5 und 3,5 liegt.A treatment solution for chronic wound treatment can be found in DE 101 40 623 A1. The treatment solution is an aqueous solution containing per liter of solution besides water and preferably sulfuric acid 10 to 100 mg of zinc, 6.5 to 65 mg of iron and in a further development the growth factor PDGF. The proportion of acid is adjusted so that the pH is between 2.5 and 3.5.
Eine Zusammensetzung für Wundbehandlungen mit einem Anteil an Silbersalzverbindungen ist aus der WO 2006/034249 A2 zu entnehmen.A composition for wound treatment with a proportion of silver salt compounds can be taken from WO 2006/034249 A2.
Aufgabe der Erfindung ist es, eine Zusammensetzung für Wundbehandlungen im Humanbereich zu benennen, mit der rasche Heilungserfolge auch bei chronischen Wunden erzielt werden.The object of the invention is to name a composition for wound treatment in the human area, can be achieved with the rapid healing success even in chronic wounds.
Die Aufgabe wird gelöst mit den Merkmalen der Unteransprüche. Vorteilhafte, nicht platt selbstverständliche Weiterbildungen sind Gegenstand der Unteransprüche. Der Erfinder hat nun in überraschender Weise festgestellt, dass die zuvor geschilderte Aufgabenstellung dadurch gelöst werden kann, dass zu dem vorgenannten Zweck eine Zusammensetzung bereitgestellt wird, die Hyaloronsäure, Harnstoff und kolloidales Silber enthält.The object is achieved with the features of the subclaims. Advantageous, not self-evident further developments are the subject of the dependent claims. The inventor has now surprisingly found that the above-described problem can be solved by providing a composition containing hyaluronic acid, urea and colloidal silver for the aforementioned purpose.
Es entfallen dabei auf 100g der Zusammensetzung 0g bis 0,9g Hyaloronsäure, 0,1g bis 40g Harnstoff und 0,01 bis Ig kolloidales Silber. Es kann jedoch einzelfallbezogen oder anwendungsbedingt erforderlich sein, von den vorgenannten Mengen abzuweichen, ohne dass dadurch der Fachmann die vorliegende Erfindung verlässt. Natürlich können alle medizinischen Silberverbindungen wie auch Silbersalze und an Antibiotika gebundene Silberverbindungen zur Anwendung gelangen.It accounts for 100g of the composition 0g to 0.9g hyaluronic acid, 0.1g to 40g urea and 0.01 to Ig colloidal silver. However, it may be necessary on a case-by-case basis or due to the application to deviate from the abovementioned amounts without the skilled person abandoning the present invention. Of course, all medicinal silver compounds as well as silver salts and antibiotics-bound silver compounds can be used.
Die Zusammensetzung enthält neben den vorgenannten Stoffen mindestens einen physiologisch und pharmakologisch unbedenklichen Träger oder Exzipienten.The composition contains, in addition to the abovementioned substances, at least one physiologically and pharmacologically acceptable carrier or excipient.
Neben den oben genannten Wirk- und/oder Inhaltsstoffen kann die erfindungsgemäße Zusammensetzung weitere, dem Fachmann geläufige Wirk- und/oder Inhaltsstoffe enthalten, insbesondere Verarbeitungsstoffe, Stabilisatoren, Emulgatoren, Antiseptika, Antioxydantien, Konservierungsstoffe, Feuchthaltungsmittel oder dergleichen.In addition to the above-mentioned active substances and / or ingredients, the composition according to the invention may comprise further active ingredients and / or ingredients familiar to the person skilled in the art, in particular processing substances, stabilizers, emulsifiers, antiseptics, antioxidants, preservatives, humectants or the like.
ersa»o»att 1. Zusammensetzung für Wundbehandlungen, dadurch gekennzeichnet, dass sie aufjelOOg Og bis 0,9g Hyaloronsäure, 0,1 bis 40,0g Harnstoff und 0,1g bis Ig kolloidales Silber enthält.ersa »o» att Composition for wound treatment, characterized in that it contains up to 0.9 g hyaluronic acid, 0.1 to 40.0 g urea and 0.1 g to Ig colloidal silver.
Die erfindungsgemäße Zusammensetzung kann in verschiedenen Formen, also als Spray, Salbe, Gel, Suspension, Pulver, Waschlotion, Tinktur, Gaze, Wundauflage, getränkte Wundauflage, Schaum oder Schwamm vorliegen. Zu näheren Einzelheiten zu den Begriffe Salbe, Paste, Creme, Gel wird auf die einschlägigen Stich worte in Römpp, Lexikon Chemie 10. Auflage, Georg Thieme Verlag, Stuttgart/NewYork verwiesen.The composition according to the invention can be present in various forms, ie as spray, ointment, gel, suspension, powder, washing lotion, tincture, gauze, wound dressing, impregnated wound dressing, foam or sponge. For more details on the terms ointment, paste, cream, gel reference is made to the relevant keywords in Römpp, Lexicon Chemistry 10th edition, Georg Thieme Verlag, Stuttgart / New York.
Die Zusammensetzung bewirkt in ihren Anwendungsformen eine lokale Antibiose ( Keimfreiheit ), eine Wundreinigung, die Auflösung von Nekrosen, eine Granulationsförderung, den Schutz der Wunde und der Wundumgebung sowie eine Epithelisierung (stabile Festigung des Zellkomplexes).In its application forms, the composition brings about local antibiosis (sterility), wound cleansing, the dissolution of necroses, granulation promotion, the protection of the wound and the wound environment, and epithelization (stable strengthening of the cell complex).
Die Zusammensetzung in Sprayform ermöglicht die Verwendung einer Knopfsonde, mit der das Spray z.B. bei Fisteln in Fistelkanäle, in Wundtaschen, in tiefe und zerklüftete Wunden, in den Analbereich, auf schlecht zugängliche Wunden, in Körperhöhlen und auf Druckstellen appliziert werden kann.The composition in spray form allows the use of a button probe with which the spray is applied e.g. can be applied to fistulas in fistula canals, wound bags, deep and ragged wounds, anal areas, poorly accessible wounds, body cavities and pressure sores.
£rsa ut>\att Drei beispielhafte Zusammensetzungen sollen nun genannt werden:£ rsa u t > \ att Three exemplary compositions will now be named:
Zusammensetzung für eine SalbeComposition for an ointment
Hyaloronsäure Natrium 0,05 gHyaluronic acid sodium 0.05 g
Kolloidales Silber 0,125 gColloidal silver 0.125 g
Harnstoff 9,0 gUrea 9.0 g
Eucerinum anhydricum 36,0 gEucerinum anhydricum 36.0 g
Gereinigtes Wasser 5,0 gPurified water 5.0 g
Zusammensetzung für Liquid (Spray) mit HyaloronsäureComposition for liquid (spray) with hyaluronic acid
Hyaloronsäure 0,25 gHyaluronic acid 0.25 g
Harnstoff 50,0 gUrea 50.0 g
Kolloidales Silber 5,0 gColloidal silver 5.0 g
Gereinigtes Wasser 194,75 gPurified water 194.75 g
Zusammensetzung für ein Liquid ohne HyaloronsäureComposition for a liquid without hyaluronic acid
Harnstoff 50,0 gUrea 50.0 g
Kolloidales Silber 5,0 gColloidal silver 5.0 g
Gereinigtes Wasser 195,0 gPurified water 195.0 g
Mit Hilfe der erfindungsgemäßen Zusammensetzung ist es möglich, auch jahrelang offene Wunden innerhalb weniger Monate zu heilen.With the aid of the composition according to the invention, it is also possible to heal open wounds for years within a few months.
Die erfindungsgemäße Zusammensetzung eignet sich für Anwendungen im Humanbereich, und im Veterinärbereich.The composition according to the invention is suitable for applications in the human and veterinary field.
&rs au^alt & rs au ^ old

Claims

Patentansprüche claims
1. Zusammensetzung für Wundbehandlungen, dadurch gekennzeichnet, dass sie aufjelOOg Og bis 0,9g Hyaloronsäure, 0,1 bis 40,0g Harnstoff und 0,1g bis Ig kolloidales Silber enthält. Kolloidales Silber kann durch medizinisch anerkannte Silberverbindungen, Silbersalze und an Antibiotika gebundene Silber in pharmakologisch sinnvoller Dosierung alternativ mit der Hyaloronsäure und dem Harnstoff kombiniert werden. Die zur Anwendung kommende Hyaloronsäure kann synthetisch hergestellt oder organischen Ursprungs sein.Composition for wound treatment, characterized in that it contains up to 0.9 g hyaluronic acid, 0.1 to 40.0 g urea and 0.1 g to Ig colloidal silver. Colloidal silver may alternatively be combined with the hyaluronic acid and the urea in a pharmacologically meaningful dosage by medically recognized silver compounds, silver salts and silver bound to antibiotics. The hyaluronic acid used may be synthetically produced or of organic origin.
£rsatzb\att Rep. B. Att
PCT/DE2008/001083 2007-09-19 2008-06-27 Composition for the treatment of wounds, containing at least silver and urea WO2009036714A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
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DE102007044582A DE102007044582A1 (en) 2007-09-19 2007-09-19 Composition for wound treatment in the human area

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Cited By (8)

* Cited by examiner, † Cited by third party
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WO2010127647A1 (en) * 2009-05-08 2010-11-11 Deckner Peter G Compositions for wound treatment in the human and veterinary field
EP2371350A1 (en) 2010-03-04 2011-10-05 Neubourg Skin Care GmbH & Co. KG Foam formulas for treating animal skin illnesses
CN102343085A (en) * 2010-08-02 2012-02-08 龚森淼 Oil in water (O/W) emulsion for treating skin trauma and preparation method of oil in water emulsion
WO2013017807A1 (en) * 2011-08-04 2013-02-07 Petcare Innovation Antiseptic composition
US9108854B2 (en) 2009-09-22 2015-08-18 Prebona Ab Biocidal colloidal dispersions of silica particles with silver ions adsorbed thereon
RU2611046C2 (en) * 2010-11-19 2017-02-20 Фидиа Фармачеутичи С.П.А. Composition with antibacterial and wound-healing activity
WO2019122429A1 (en) 2017-12-21 2019-06-27 Prebona Ab Pharmaceutical composition comprising a colloidal dispersion and a therapeutic agent and methods and uses thereof
US11191776B1 (en) * 2013-10-23 2021-12-07 Donald Wayne Jessup Hyaluronic acid formulation

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WO2006034249A2 (en) * 2004-09-20 2006-03-30 Acrymed, Inc. Antimicrobial amorphous compositions
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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010127647A1 (en) * 2009-05-08 2010-11-11 Deckner Peter G Compositions for wound treatment in the human and veterinary field
US9108854B2 (en) 2009-09-22 2015-08-18 Prebona Ab Biocidal colloidal dispersions of silica particles with silver ions adsorbed thereon
EP2371350A1 (en) 2010-03-04 2011-10-05 Neubourg Skin Care GmbH & Co. KG Foam formulas for treating animal skin illnesses
CN102343085A (en) * 2010-08-02 2012-02-08 龚森淼 Oil in water (O/W) emulsion for treating skin trauma and preparation method of oil in water emulsion
RU2611046C2 (en) * 2010-11-19 2017-02-20 Фидиа Фармачеутичи С.П.А. Composition with antibacterial and wound-healing activity
WO2013017807A1 (en) * 2011-08-04 2013-02-07 Petcare Innovation Antiseptic composition
WO2013017808A1 (en) * 2011-08-04 2013-02-07 Dermaconcept Jmc Antiseptic composition
FR2978664A1 (en) * 2011-08-04 2013-02-08 Petcare Innovation ANTISEPTIC COMPOSITION
FR2978665A1 (en) * 2011-08-04 2013-02-08 Petcare Innovation ANTISEPTIC COMPOSITION
US11191776B1 (en) * 2013-10-23 2021-12-07 Donald Wayne Jessup Hyaluronic acid formulation
WO2019122429A1 (en) 2017-12-21 2019-06-27 Prebona Ab Pharmaceutical composition comprising a colloidal dispersion and a therapeutic agent and methods and uses thereof

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