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WO2009028338A1 - 新規オキシダーゼ遺伝子、および該遺伝子を利用する３－インドールピルビン酸の製造方法 - Google Patents

新規オキシダーゼ遺伝子、および該遺伝子を利用する３－インドールピルビン酸の製造方法 Download PDF

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Publication number
WO2009028338A1
WO2009028338A1 PCT/JP2008/064635 JP2008064635W WO2009028338A1 WO 2009028338 A1 WO2009028338 A1 WO 2009028338A1 JP 2008064635 W JP2008064635 W JP 2008064635W WO 2009028338 A1 WO2009028338 A1 WO 2009028338A1
Authority
WO
WIPO (PCT)
Prior art keywords
indole
gene
pyruvic acid
producing
transformant
Prior art date
Application number
PCT/JP2008/064635
Other languages
English (en)
French (fr)
Inventor
Yasuaki Takakura
Seiichi Hara
Toshiki Taba
Shunichi Suzuki
Masakazu Sugiyama
Kunihiko Watanabe
Kenzo Yokozeki
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to CN200880104143XA priority Critical patent/CN102027117B/zh
Publication of WO2009028338A1 publication Critical patent/WO2009028338A1/ja
Priority to US12/711,719 priority patent/US8394940B2/en
Priority to US13/684,888 priority patent/US8518665B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

　本発明は、安価かつ簡便な３－インドールピルビン酸の製造を実現するための手段を提供することを課題とする。オキシダーゼ活性を有するタンパク質をコードする所定の塩基配列を有するポリヌクレオチドを用いて形質転換体を作製し、その形質転換体を培地中で培養し、培地中および／または形質転換体中に、オキシダーゼを蓄積させてオキシダーゼを生成する。さらに、前記形質転換体および／またはその培養物の存在下で、トリプトファンを３－インドールピルビン酸に変換し、３－インドールピルビン酸を製造する。
PCT/JP2008/064635 2007-08-24 2008-08-15 新規オキシダーゼ遺伝子、および該遺伝子を利用する３－インドールピルビン酸の製造方法 WO2009028338A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN200880104143XA CN102027117B (zh) 2007-08-24 2008-08-15 新的氧化酶基因及使用该基因生产3-吲哚-丙酮酸的方法
US12/711,719 US8394940B2 (en) 2007-08-24 2010-02-24 Oxidase gene and method for producing 3-indole-pyruvic acid by utilizing the gene
US13/684,888 US8518665B2 (en) 2007-08-24 2012-11-26 Methods for making 3-indole-pyruvic acid from tryptophan using a tryptophan deaminase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-218955 2007-08-24
JP2007218955 2007-08-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/711,719 Continuation US8394940B2 (en) 2007-08-24 2010-02-24 Oxidase gene and method for producing 3-indole-pyruvic acid by utilizing the gene

Publications (1)

Publication Number Publication Date
WO2009028338A1 true WO2009028338A1 (ja) 2009-03-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/064635 WO2009028338A1 (ja) 2007-08-24 2008-08-15 新規オキシダーゼ遺伝子、および該遺伝子を利用する３－インドールピルビン酸の製造方法

Country Status (3)

Country Link
US (2) US8394940B2 (ja)
CN (1) CN102027117B (ja)
WO (1) WO2009028338A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012050125A1 (ja) 2010-10-14 2012-04-19 味の素株式会社 モナティンの製造方法
WO2017122747A1 (en) 2016-01-12 2017-07-20 Ajinomoto Co., Inc. Method for producing benzaldehyde
WO2021085405A1 (ja) 2019-10-28 2021-05-06 味の素株式会社 ベンズアルデヒドの製造方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7297800B2 (en) * 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
CN1678742B (zh) 2002-08-26 2013-07-17 味之素株式会社 新型醛缩酶和取代α-酮酸的制备方法
KR100723826B1 (ko) 2002-12-09 2007-06-04 아지노모토 가부시키가이샤 변이형 ｄ－아미노트랜스퍼라제 및 이를 사용하는 광학활성글루탐산 유도체의 제조방법
US20090198072A1 (en) * 2006-05-24 2009-08-06 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
US8003361B2 (en) * 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
US8076107B2 (en) * 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8367847B2 (en) * 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
US8771997B2 (en) 2011-04-20 2014-07-08 Ajinomoto Co., Inc. Method for producing monatin using an L-amino acid aminotransferase
CN111996178B (zh) * 2020-09-14 2022-01-28 山东阳成生物科技有限公司 一种组氨醇磷酸氨基转移酶突变体、工程菌及应用

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JPH04218386A (ja) * 1990-05-25 1992-08-07 Nok Corp インド−ルピルビン酸の製造方法
WO2003056026A1 (fr) * 2001-12-27 2003-07-10 Ajinomoto Co., Inc. Procede de production de derives d'acide glutamique

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DE297190C (ja)
JPS57146573A (en) 1981-03-06 1982-09-10 Noda Sangyo Kagaku Kenkyusho Novel l-phenylalanineoxidase and its preparation
IT1148618B (it) * 1982-10-11 1986-12-03 Polifarma Spa Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
IT1184282B (it) 1985-06-28 1987-10-22 Polifarma Spa Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico
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US7297800B2 (en) * 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
US7572607B2 (en) * 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
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CN1678742B (zh) * 2002-08-26 2013-07-17 味之素株式会社 新型醛缩酶和取代α-酮酸的制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04218386A (ja) * 1990-05-25 1992-08-07 Nok Corp インド−ルピルビン酸の製造方法
WO2003056026A1 (fr) * 2001-12-27 2003-07-10 Ajinomoto Co., Inc. Procede de production de derives d'acide glutamique

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012050125A1 (ja) 2010-10-14 2012-04-19 味の素株式会社 モナティンの製造方法
WO2017122747A1 (en) 2016-01-12 2017-07-20 Ajinomoto Co., Inc. Method for producing benzaldehyde
WO2021085405A1 (ja) 2019-10-28 2021-05-06 味の素株式会社 ベンズアルデヒドの製造方法

Also Published As

Publication number Publication date
CN102027117B (zh) 2012-11-07
US8518665B2 (en) 2013-08-27
US20130084610A1 (en) 2013-04-04
US8394940B2 (en) 2013-03-12
US20100221795A1 (en) 2010-09-02
CN102027117A (zh) 2011-04-20

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